LOCUS 005_Delta5_auf_Barbe 3908915 bp DNA circular CON 12-JAN-2021 DEFINITION Bacillus subtilis subsp. subtilis str. 168 complete genome. ACCESSION NC_000964 DBLINK BioProject: PRJNA76 BioSample: SAMEA3138188 KEYWORDS RefSeq; complete genome. SOURCE Bacillus subtilis subsp. subtilis str. 168 ORGANISM Bacillus subtilis subsp. subtilis str. 168 Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus. REFERENCE 1 AUTHORS Borriss,R., Danchin,A., Harwood,C.R., Medigue,C., Rocha,E.P.C., Sekowska,A. and Vallenet,D. TITLE Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement JOURNAL Microb Biotechnol 11 (1), 3-17 (2018) PUBMED 29280348 REFERENCE 2 (bases 1 to 4215606) AUTHORS Belda,E., Sekowska,A., Le, Fevre,F., Morgat,A., Mornico,D., Ouzounis,C., Vallenet,D., Medigue,C. and Danchin,A. TITLE An updated metabolic view of the Bacillus subtilis 168 genome JOURNAL Microbiology (Reading, Engl.) 159 (Pt 4), 757-770 (2013) PUBMED 23429746 REFERENCE 3 (bases 1 to 4215606) AUTHORS Barbe,V., Cruveiller,S., Kunst,F., Lenoble,P., Meurice,G., Sekowska,A., Vallenet,D., Wang,T., Moszer,I., Medigue,C. and Danchin,A. TITLE From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later JOURNAL Microbiology (Reading, Engl.) 155 (Pt 6), 1758-1775 (2009) PUBMED 19383706 REFERENCE 4 (bases 1 to 4215606) AUTHORS Kunst,F., Ogasawara,N., Moszer,I., Albertini,A.M., Alloni,G., Azevedo,V., Bertero,M.G., Bessieres,P., Bolotin,A., Borchert,S., Borriss,R., Boursier,L., Brans,A., Braun,M., Brignell,S.C., Bron,S., Brouillet,S., Bruschi,C.V., Caldwell,B., Capuano,V., Carter,N.M., Choi,S.K., Cordani,J.J., Connerton,I.F., Cummings,N.J., Daniel,R.A., Denziot,F., Devine,K.M., Dusterhoft,A., Ehrlich,S.D., Emmerson,P.T., Entian,K.D., Errington,J., Fabret,C., Ferrari,E., Foulger,D., Fritz,C., Fujita,M., Fujita,Y., Fuma,S., Galizzi,A., Galleron,N., Ghim,S.Y., Glaser,P., Goffeau,A., Golightly,E.J., Grandi,G., Guiseppi,G., Guy,B.J., Haga,K., Haiech,J., Harwood,C.R., Henaut,A., Hilbert,H., Holsappel,S., Hosono,S., Hullo,M.F., Itaya,M., Jones,L., Joris,B., Karamata,D., Kasahara,Y., Klaerr-Blanchard,M., Klein,C., Kobayashi,Y., Koetter,P., Koningstein,G., Krogh,S., Kumano,M., Kurita,K., Lapidus,A., Lardinois,S., Lauber,J., Lazarevic,V., Lee,S.M., Levine,A., Liu,H., Masuda,S., Mauel,C., Medigue,C., Medina,N., Mellado,R.P., Mizuno,M., Moestl,D., Nakai,S., Noback,M., Noone,D., O'Reilly,M., Ogawa,K., Ogiwara,A., Oudega,B., Park,S.H., Parro,V., Pohl,T.M., Portelle,D., Porwollik,S., Prescott,A.M., Presecan,E., Pujic,P., Purnelle,B., Rapoport,G., Rey,M., Reynolds,S., Rieger,M., Rivolta,C., Rocha,E., Roche,B., Rose,M., Sadaie,Y., Sato,T., Scanlan,E., Schleich,S., Schroeter,R., Scoffone,F., Sekiguchi,J., Sekowska,A., Seror,S.J., Serror,P., Shin,B.S., Soldo,B., Sorokin,A., Tacconi,E., Takagi,T., Takahashi,H., Takemaru,K., Takeuchi,M., Tamakoshi,A., Tanaka,T., Terpstra,P., Togoni,A., Tosato,V., Uchiyama,S., Vandebol,M., Vannier,F., Vassarotti,A., Viari,A., Wambutt,R., Wedler,H., Weitzenegger,T., Winters,P., Wipat,A., Yamamoto,H., Yamane,K., Yasumoto,K., Yata,K., Yoshida,K., Yoshikawa,H.F., Zumstein,E., Yoshikawa,H. and Danchin,A. TITLE The complete genome sequence of the gram-positive bacterium Bacillus subtilis JOURNAL Nature 390 (6657), 249-256 (1997) PUBMED 9384377 REFERENCE 5 (bases 1 to 4215606) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (17-SEP-2018) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 6 (bases 1 to 4215606) AUTHORS Genoscope and -,C.E.A. CONSRTM AMAbiotics and Genoscope TITLE Direct Submission JOURNAL Submitted (24-JAN-2013) A. Danchin, AMAbiotics, Bldg G1, 2, rue Gaston Cremieux, 91000 EVRY antoine.danchin@normalesup.org Bldg G1 Genoscope / CEA (Commissariat a l'energie atomique et aux energies alternatives): BP 191 91006 EVRY cedex - FRANCE (E-mail: seqref@genoscope.cns.fr - Web: www.genoscope.cns.fr) REFERENCE 7 (bases 1 to 4215606) AUTHORS Genoscope and -,C.E.A. CONSRTM Institut Pasteur and Genoscope TITLE Direct Submission JOURNAL Submitted (29-JAN-2009) Genoscope - Centre National de Sequencage : BP 191 91006 EVRY cedex - FRANCE (E-mail : seqref@genoscope.cns.fr - Web : www.genoscope.cns.fr) REFERENCE 8 (bases 1 to 4215606) AUTHORS Kunst,F., Ogasawara,N., Yoshikawa,H. and Danchin,A. TITLE Direct Submission JOURNAL Submitted (18-NOV-1997) I. Moszer, A. Danchin, Genetique des Genomes Bacteriens, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, FRANCE. E-mail: moszer@pasteur.fr, antoine.danchin@normalesup.org Phone: +33 (0)1 45 68 84 41, Fax: +33 (0)1 45 68 89 48 COMMENT ##gff-version-START## gff-version :: 3 ##gff-version-END## FEATURES Location/Qualifiers S_feature 1..148 /Source="Nicolas_S_feature" /locus_tag="new_1_148" /HighExp="T0.30H, C30, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, S2, T-1.10H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1" S_feature complement(24..297) /Source="Nicolas_S_feature" /locus_tag="new_24_297_c" /HighExp="S8, C30, Etha, S3, S7, S4, Cold, BT, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.178448" /TUshortSig="SigK, SigEF" /TUshortPSig="0.621, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S2" promotor_-35 120..124 /Source="Nicolas_upshift_promotors" /id="U1" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=2521 /SigmaFactorBS="tgtccgctttgtggataagattgtgacaacCATTGcaagctc tcgtttatTTTGGTATTATATTTGTGTTttaactcttgattactaatcctacctttcc t" /listShort="S3, dnaA, S5, dnaN, yaaA, recF" /listLong="yaaB, gyrB, S6, gyrA" /label="promotor_-35" promotor_-10 140..159 /Source="Nicolas_upshift_promotors" /id="U1" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=2521 /SigmaFactorBS="tgtccgctttgtggataagattgtgacaacCATTGcaagctc tcgtttatTTTGGTATTATATTTGTGTTttaactcttgattactaatcctacctttcc t" /listShort="S3, dnaA, S5, dnaN, yaaA, recF" /listLong="yaaB, gyrB, S6, gyrA" /label="promotor_-10" S_feature 150..409 /Source="Nicolas_S_feature" /locus_tag="new_150_409" /HighExp="Heat, G180, LPhT, G150, dia15, Oxctl, S1, G135, LBGstat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S3" upshifts 150 /Source="Nicolas_upshifts" /id="U1" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=2521 /SigmaFactorBS="tgtccgctttgtggataagattgtgacaacCATTGcaagctc tcgtttatTTTGGTATTATATTTGTGTTttaactcttgattactaatcctacctttcc t" /listShort="S3, dnaA, S5, dnaN, yaaA, recF" /listLong="yaaB, gyrB, S6, gyrA" promotor_-10 complement(285..304) /Source="Nicolas_upshift_promotors" /id="U2" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.621378621378621" /psig="0.621378621378621" /xcortree=272 /SigmaFactorBS="aacacaaaaaaagagcaaatggcgcttaccaTTCGTACACat taaatgttgaaAACATATAATATAGTAGATAaatagcttttcgacaaatttcacaact t" /listShort="S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(297) /Source="Nicolas_upshifts" /id="U2" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.621378621378621" /psig="0.621378621378621" /xcortree=272 /SigmaFactorBS="aacacaaaaaaagagcaaatggcgcttaccaTTCGTACACat taaatgttgaaAACATATAATATAGTAGATAaatagcttttcgacaaatttcacaact t" /listShort="S2" /GFF_Attribute="listLong" S_feature complement(299..1067) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" promotor_-35 complement(318..326) /Source="Nicolas_upshift_promotors" /id="U2" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.621378621378621" /psig="0.621378621378621" /xcortree=272 /SigmaFactorBS="aacacaaaaaaagagcaaatggcgcttaccaTTCGTACACat taaatgttgaaAACATATAATATAGTAGATAaatagcttttcgacaaatttcacaact t" /listShort="S2" /GFF_Attribute="listLong" /label="promotor_-35" CDS 410..1750 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" gene 410..1750 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" promotor_-10 complement(1040..1058) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1066) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" promotor_-35 complement(1074..1079) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1751..1938 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1939..3075 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" gene 1939..3075 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" downshifts 3059 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" promotor_-35 3140..3144 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3161..3180 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3169 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" CDS 3206..3421 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" gene 3206..3421 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" CDS 3437..4549 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" gene 3437..4549 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" misc_feature 3635..3654 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3653 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" CDS 4567..4812 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" gene 4567..4812 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" CDS 4867..6783 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" gene 4867..6783 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" promotor_-10 complement(6412..6430) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6414) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(6446..6451) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6784..6993 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6994..9459 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" gene 6994..9459 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" promotor_-35 9373..9376 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9374 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 9393..9410 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9440 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" promotor_-35 9504..9510 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9524..9543 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9529..9614 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9529 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" promotor_-35 9600..9607 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9616 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 9622..9641 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9810..11364 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 9810..11364 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" tRNA 11464..11540 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 11464..11540 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" tRNA 11552..11627 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 11552..11627 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" rRNA 11709..14636 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 11709..14636 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" rRNA 14692..14810 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 14692..14810 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" S_feature 14811..15868 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14847..15794) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" gene complement(14847..15794) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" promotor_-35 15847..15854 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15869..15888 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15870 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" upshifts complement(15875) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" promotor_-10 complement(15884..15895) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15909..15915) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15915..17381 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" gene 15915..17381 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" downshifts complement(15919) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(15945..16045) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15985) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(17238..17833) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 17369 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" promotor_-35 17427..17431 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17447..17466 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17453..17533 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17453 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" CDS 17534..18865 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" gene 17534..18865 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" promotor_-10 complement(17822..17840) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17833) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" promotor_-35 complement(17855..17861) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18747 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" S_feature 18866..18974 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18944..18947 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18962..18981 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18976..19061 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18976 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" CDS 19062..19946 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" gene 19062..19946 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" S_feature complement(19194..19923) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19911..19929) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19923) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" promotor_-35 complement(19945..19950) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19968..20558 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" gene 19968..20558 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" misc_RNA 20611..20823 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene 20611..20823 /gene="tboS" /locus_tag="BSU_misc_RNA_1" downshifts 20788 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" CDS 20880..22157 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" gene 20880..22157 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" downshifts 22135 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" promotor_-35 22246..22253 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 22268..22287 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 22268 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" tRNA 22292..22384 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 22292..22384 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" downshifts 22407 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" S_feature 22452..22529 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22496..23149) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " gene complement(22496..23149) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" promotor_-35 22515..22521 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22520) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" S_feature 22531..23167 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22531 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 22535..22546 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(23146..23769) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" gene complement(23146..23769) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" promotor_-10 complement(23810..23829) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23828) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" promotor_-35 complement(23845..23849) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23868..25151) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" gene complement(23868..25151) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" downshifts complement(23905) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(25182..25200) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25203) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" promotor_-35 complement(25216..25221) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(25221..25766) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" gene complement(25221..25766) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" promotor_-35 25632..25636 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25651..25670 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25655..25851 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25657 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" promotor_-10 complement(25791..25809) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25810) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" promotor_-35 complement(25824..25830) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25852..26337 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" gene 25852..26337 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" promotor_-35 26341..26347 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 26379..26732 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" gene 26379..26732 /gene="scr" /locus_tag="BSU_misc_RNA_2" S_feature 26383..26532 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 26383 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" S_feature 26636..26731 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26688 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" promotor_-35 26752..26755 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26770..26789 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26779 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" CDS 26814..28505 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" gene 26814..28505 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" promotor_-35 28346..28353 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 28368..28387 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 28383 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" CDS 28529..28852 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" gene 28529..28852 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" CDS 28867..29463 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" gene 28867..29463 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" CDS 29481..29705 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" gene 29481..29705 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" promotor_-35 29708..29713 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29725 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" promotor_-10 29729..29747 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29772..30035 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" gene 29772..30035 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" promotor_-35 30048..30055 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 30069..30088 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 30076..30278 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 30076 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" rRNA 30279..31832 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 30279..31832 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" tRNA 31932..32008 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 31932..32008 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" tRNA 32020..32095 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 32020..32095 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" rRNA 32177..35103 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 32177..35103 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" S_feature 35104..35236 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 35237..35355 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 35237..35355 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" S_feature 35356..35458 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35419..35427 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35441..35460 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35460 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" CDS 35531..35725 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" gene 35531..35725 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" downshifts 35709 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" promotor_-35 35770..35779 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35791..35806 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35797 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" CDS 35845..36459 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" gene 35845..36459 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" CDS 36478..37638 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" gene 36478..37638 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" S_feature 37639..37719 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37720..39162 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" gene 37720..39162 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" promotor_-35 39082..39088 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 39103..39121 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 39112 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" CDS 39159..39797 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" gene 39159..39797 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" promotor_-35 39792..39799 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39812..39831 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39823 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" CDS 39871..40200 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" gene 39871..40200 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" CDS 40213..40653 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" gene 40213..40653 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" CDS 40665..41654 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" gene 40665..41654 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" CDS 41657..42484 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " gene 41657..42484 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" CDS 42499..42858 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" gene 42499..42858 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" CDS 42917..43660 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" gene 42917..43660 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" CDS 43647..43946 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" gene 43647..43946 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" CDS 43921..44799 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" gene 43921..44799 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" downshifts 44772 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" CDS complement(44848..45138) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" gene complement(44848..45138) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" downshifts complement(44850) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" downshifts 45169 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" promotor_-10 complement(45205..45224) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45222) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" S_feature complement(45224..45399) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(45238..45245) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(45395..45414) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(45399) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" promotor_-35 complement(45428..45435) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45499..45503 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45518..45537 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45524..45632 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45524 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" CDS 45633..47627 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" gene 45633..47627 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" promotor_-10 complement(46381..46400) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(46389) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(46416..46420) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47611 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" S_feature complement(47673..50019) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47706..48473 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" gene 47706..48473 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" S_feature 48474..48554 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48531..48536 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48552..48570 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48556 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" promotor_-35 48581..48584 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48599..48618 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48616 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" CDS 48629..49942 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" gene 48629..49942 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" promotor_-35 48649..48656 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48667 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" promotor_-10 48671..48690 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49903 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" promotor_-35 49965..49969 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49985..50004 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49987..50086 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49987 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" promotor_-10 complement(50011..50026) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(50027) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" promotor_-35 complement(50038..50047) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 50083..50099 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 50087..50647 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" gene 50087..50647 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" upshifts 50097 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" CDS 50640..51518 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" gene 50640..51518 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" downshifts 51483 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" promotor_-35 51533..51542 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51556..51575 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51558..51679 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51558 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" CDS 51680..52552 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" gene 51680..52552 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" downshifts 52539 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" S_feature 52649..52719 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52710..52717 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52721 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" promotor_-10 52731..52750 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52740..52754) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52747) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(52763..52767) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52763..53023 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" gene 52763..53023 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" downshifts 52935 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" downshifts 53022 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" promotor_-35 53088..53094 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 53108..53119 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 53111..53182 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 53111 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" CDS 53183..53368 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" gene 53183..53368 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" downshifts 53353 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" S_feature complement(53363..55717) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53446..53450 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53466..53485 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53469 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" CDS 53516..54385 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" gene 53516..54385 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" CDS 54441..55298 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" gene 54441..55298 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" CDS 55295..55672 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" gene 55295..55672 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" downshifts 55662 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" promotor_-10 complement(55706..55724) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55707..55815 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55718) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" promotor_-35 complement(55740..55745) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55795..55803 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55814..55832 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55817 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" CDS 55866..56159 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" gene 55866..56159 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" downshifts 56148 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" S_feature 56193..56304 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 56286..56290 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 56306..56325 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 56306 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" CDS 56352..57722 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" gene 56352..57722 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" downshifts complement(57697) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" CDS 57745..58698 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" gene 57745..58698 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" promotor_-35 58711..58717 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58730 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" promotor_-10 58732..58750 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58783..59397 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" gene 58783..59397 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" downshifts 59381 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" CDS 59504..60070 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" gene 59504..60070 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" misc_feature 59683..59686 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59689 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" CDS 60130..60360 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" gene 60130..60360 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" S_feature 60361..60429 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60430..63963 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" gene 60430..63963 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" promotor_-35 63981..63987 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 64001..64098 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 64001..64012 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 64001 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" CDS 64099..64635 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" gene 64099..64635 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" downshifts 64639 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" misc_feature 64735..64754 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64746 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" CDS 64817..66415 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" gene 64817..66415 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" promotor_-35 66286..66293 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 66308..66327 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 66322 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" CDS 66405..67874 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" gene 66405..67874 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" promotor_-35 67046..67053 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 67067..67085 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 67081 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" promotor_no_box complement(67469..67569) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67509) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 67877..68137 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" gene 67877..68137 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" promotor_-35 68142..68147 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68163..68181 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68181 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" downshifts complement(68213) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" CDS 68216..68518 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" gene 68216..68518 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" CDS 68515..69150 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" gene 68515..69150 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" promotor_-35 69020..69029 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69042..69057 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69044 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" promotor_-35 69076..69084 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69095..69113 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69105 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" CDS 69168..69545 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" gene 69168..69545 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" CDS 69626..70012 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" gene 69626..70012 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" downshifts 70006 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" promotor_-35 70120..70127 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 70141..70160 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 70156 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" tRNA 70181..70257 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 70181..70257 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" tRNA 70267..70338 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 70267..70338 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" downshifts 70337 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" S_feature 70382..70493 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70489..70508 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70495 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" CDS 70538..73021 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" gene 70538..73021 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" downshifts 70579 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" S_feature complement(71190..71799) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(71216) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" promotor_-10 complement(71772..71790) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71798) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" promotor_-35 complement(71806..71811) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 72003..72009 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72024..72042 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72031 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" promotor_-35 73041..73044 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 73062..73079 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 73065 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" CDS 73106..73843 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" gene 73106..73843 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" CDS 73809..74825 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" gene 73809..74825 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" promotor_-35 74357..74363 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 74379..74397 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 74385 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" promotor_-35 74855..74862 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74876..74895 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74886 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" CDS 74929..76347 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" gene 74929..76347 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" promotor_-35 75724..75731 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75746..75765 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75749 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" downshifts complement(76342) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" CDS 76344..76886 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" gene 76344..76886 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" upshifts complement(76749) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(76751..76755) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76773..76776) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76887..76983 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76984..78897 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" gene 76984..78897 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" downshifts 78895 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" misc_feature complement(78934..78938) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78940..79025 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78942) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 79002..79009 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 79023..79042 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 79027..79091 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 79027 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" CDS 79092..79868 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" gene 79092..79868 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" CDS 79880..80755 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" gene 79880..80755 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" CDS 80802..81695 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" gene 80802..81695 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" promotor_-35 81425..81430 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81447..81465 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81448 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" promotor_-35 81694..81701 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81716..81735 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81723 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" CDS 81771..82697 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" gene 81771..82697 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" downshifts 82690 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" promotor_-35 82744..82752 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82766..82774 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82768 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" promotor_-35 82796..82799 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82814..82833 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82824 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" CDS 82864..84276 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" gene 82864..84276 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" promotor_-35 83666..83668 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83686..83704 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83692 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" promotor_-35 84033..84040 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 84053..84072 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 84066 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" CDS 84290..84874 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" gene 84290..84874 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" CDS 84874..85755 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" gene 84874..85755 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" CDS 85737..86594 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" gene 85737..86594 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" CDS 86587..86949 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" gene 86587..86949 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" CDS 86946..87449 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" gene 86946..87449 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" CDS 87401..87610 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" gene 87401..87610 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" CDS 87634..88635 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " gene 87634..88635 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" S_feature complement(88050..89566) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88636..88726 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88727..90226 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" gene 88727..90226 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" promotor_-10 complement(89550..89568) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89566) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" promotor_-35 complement(89584..89589) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 90207 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" promotor_-35 90302..90309 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 90318..90535 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 90318 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" promotor_-10 90323..90342 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(90368) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" rRNA 90536..92089 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 90536..92089 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" rRNA 92254..95181 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 92254..95181 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" rRNA 95237..95354 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95237..95354 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" tRNA 95375..95450 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95375..95450 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" tRNA 95455..95530 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95455..95530 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" tRNA 95567..95642 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95567..95642 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" tRNA 95649..95731 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95649..95731 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" tRNA 95772..95846 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95772..95846 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" tRNA 95861..95946 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95861..95946 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" tRNA 95956..96032 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" gene 95956..96032 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" tRNA 96060..96136 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 96060..96136 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" tRNA 96146..96221 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 96146..96221 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" rRNA 96392..97945 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 96392..97945 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" rRNA 98110..101037 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 98110..101037 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" rRNA 101093..101211 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 101093..101211 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" S_feature 101212..101289 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 101259..101262 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 101278..101297 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 101291 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" promotor_-35 101325..101331 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 101345..101364 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 101356 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" promotor_-35 101371..101378 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 101392..101411 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 101404 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 101449..101913 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" gene 101449..101913 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" misc_feature complement(101560..101564) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101566) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 101927..102484 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" gene 101927..102484 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" CDS 102484..103575 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" gene 102484..103575 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" CDS 103572..106004 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" gene 103572..106004 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" downshifts 105999 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" CDS 106096..107472 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" gene 106096..107472 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" promotor_-35 106551..106560 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106573..106588 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106576 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 107476..108558 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" gene 107476..108558 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" S_feature 108559..108673 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108674..109774 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" gene 108674..109774 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" downshifts complement(109596) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" CDS 109789..110487 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" gene 109789..110487 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" CDS 110480..110956 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" gene 110480..110956 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" promotor_-35 110960..110967 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110981..111000 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110994 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 111047..112498 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" gene 111047..112498 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" promotor_-35 111976..111985 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111999..112018 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111999 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" S_feature 112499..112799 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112800..113453 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " gene 112800..113453 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" CDS 113450..114850 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" gene 113450..114850 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" CDS 114854..115285 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" gene 114854..115285 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" CDS 115269..116018 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" gene 115269..116018 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" CDS 116025..116537 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" gene 116025..116537 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" promotor_-35 116536..116543 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116558..116577 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116560 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 116600..117256 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" gene 116600..117256 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" downshifts complement(117054) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" S_feature 117257..117348 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 117349..117498 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" gene 117349..117498 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" CDS 117532..117711 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" gene 117532..117711 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" S_feature 117712..117889 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117883) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" CDS 117890..118423 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" gene 117890..118423 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" upshifts complement(117978) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(117981..117985) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(118000..118005) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118434..118441 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118452..118590 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118452 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" promotor_-10 118455..118474 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118591..119016 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" gene 118591..119016 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" S_feature 119017..119110 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 119111..119809 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" gene 119111..119809 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" downshifts complement(119783) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" misc_RNA 119855..119995 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" gene 119855..119995 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" upshifts complement(119871) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(119874..119878) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119927 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" CDS 120061..120561 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" gene 120061..120561 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" CDS 120607..120978 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" gene 120607..120978 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" downshifts 120894 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" downshifts 120967 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" CDS 121068..121673 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" gene 121068..121673 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" promotor_-35 121668..121672 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121686..121918 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121686 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" promotor_-10 121688..121707 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121919..125500 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" gene 121919..125500 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" promotor_-10 complement(123504..123523) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123507) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(123537..123546) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(124375..124379) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(124380) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(124394..124400) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125562..129161 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" gene 125562..129161 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" downshifts complement(128626) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" upshifts complement(128780) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(128798..128799) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(129110) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" S_feature 129162..129283 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 129265..129272 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 129285 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" promotor_-10 129286..129305 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(129303..129307) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(129306) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 129340..129588 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" gene 129340..129588 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" S_feature 129589..129701 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129702..130118 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" gene 129702..130118 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" CDS 130160..130630 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" gene 130160..130630 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" CDS 130684..132762 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" gene 130684..132762 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" S_feature 132763..132881 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132882..134072 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" gene 132882..134072 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" downshifts 134067 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" misc_feature complement(134098..134101) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(134102) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 134128..134147 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 134136 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 134171..135127 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" gene 134171..135127 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" promotor_-35 135134..135141 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 135155..135174 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 135170..135363 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 135170 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" CDS 135364..135672 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" gene 135364..135672 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" CDS 135712..136341 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" gene 135712..136341 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" CDS 136369..136992 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" gene 136369..136992 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" CDS 136992..137279 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" gene 136992..137279 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" CDS 137311..138144 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" gene 137311..138144 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" downshifts complement(137447) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" CDS 138202..138480 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" gene 138202..138480 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" CDS 138497..138838 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" gene 138497..138838 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" CDS 138842..139498 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" gene 138842..139498 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" downshifts complement(138855) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(138936..138940) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138943) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(138957..138959) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139500..139934 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" gene 139500..139934 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" CDS 139924..140124 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" gene 139924..140124 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" CDS 140147..140410 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" gene 140147..140410 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" CDS 140451..140819 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" gene 140451..140819 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" CDS 140857..141168 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" gene 140857..141168 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" CDS 141195..141734 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" gene 141195..141734 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" CDS 141757..141942 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" gene 141757..141942 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" CDS 141974..142372 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" gene 141974..142372 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" downshifts complement(142375) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" CDS 142402..142941 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" gene 142402..142941 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" CDS 142974..143336 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" gene 142974..143336 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" CDS 143361..143861 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" gene 143361..143861 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" CDS 143875..144054 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" gene 143875..144054 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" CDS 144085..144525 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" gene 144085..144525 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" CDS 144527..145822 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" gene 144527..145822 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" CDS 145877..146530 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " gene 145877..146530 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" CDS 146527..147273 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" gene 146527..147273 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" CDS 147312..147536 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" gene 147312..147536 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" CDS 147585..147803 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" gene 147585..147803 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" CDS 147837..147950 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" gene 147837..147950 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" CDS 147973..148338 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" gene 147973..148338 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" CDS 148359..148754 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" gene 148359..148754 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" S_feature 148755..148930 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148931..149875 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" gene 148931..149875 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" CDS 149953..150315 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" gene 149953..150315 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" downshifts 150317 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" S_feature 150362..150442 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150443..151288 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" gene 150443..151288 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" CDS 151303..152133 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" gene 151303..152133 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" CDS 152130..152927 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" gene 152130..152927 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" CDS 152937..153680 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" gene 152937..153680 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" S_feature complement(153039..153507) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 153172..153177 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153192..153209 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153211 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" promotor_-10 complement(153507..153526) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153529) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" promotor_-35 complement(153539..153548) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153700..153706 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153721..153740 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153725 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" misc_RNA 153737..153793 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" gene 153737..153793 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" CDS 153842..154279 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" gene 153842..154279 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" CDS 154300..154692 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" gene 154300..154692 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" downshifts 154667 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" promotor_-35 154809..154816 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154830..154849 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154838..155119 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154838 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" misc_feature 155118..155137 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 155121 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" CDS 155156..155923 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" gene 155156..155923 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" downshifts 155914 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" promotor_-35 156053..156059 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156074..156085 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156081 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" CDS 156109..156552 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" gene 156109..156552 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" promotor_-35 156552..156557 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156573..156591 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156574 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" CDS 156612..157325 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" gene 156612..157325 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" upshifts 157370 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" misc_feature 157373..157392 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157421..158479 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" gene 157421..158479 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" S_feature complement(158050..158514) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158465 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" S_feature 158510..159181 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158515..159072) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" gene complement(158515..159072) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" promotor_-10 complement(159104..159115) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(159116) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" promotor_-35 complement(159129..159135) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(159149..159778) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 159182..159778 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" gene 159182..159778 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" S_feature 159779..160673 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159779..160543) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" gene complement(159779..160543) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" promotor_-10 complement(160574..160592) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160594) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" promotor_-35 complement(160608..160613) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160651..160658 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160673..160692 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160675..160892 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160675 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" rRNA 160893..162445 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 160893..162445 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" rRNA 162610..165535 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 162610..165535 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" rRNA 165591..165707 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 165591..165707 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" tRNA 165754..165825 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 165754..165825 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" tRNA 165830..165902 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 165830..165902 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" tRNA 165959..166033 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 165959..166033 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" tRNA 166064..166140 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 166064..166140 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" tRNA 166168..166244 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 166168..166244 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" tRNA 166253..166328 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 166253..166328 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" rRNA 166500..168053 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 166500..168053 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" rRNA 168218..171141 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 168218..171141 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" rRNA 171197..171314 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 171197..171314 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" rRNA 171498..173049 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 171498..173049 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" rRNA 173214..176141 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 173214..176141 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" rRNA 176197..176315 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 176197..176315 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" S_feature 176316..176924 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176892..176896 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176912..176931 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176926..177082 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176926 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" CDS 177083..178519 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" gene 177083..178519 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" downshifts 178508 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" promotor_-35 178562..178567 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178580..178599 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178598 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" CDS 178665..179585 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" gene 178665..179585 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" downshifts 179566 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" CDS complement(179595..180347) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" gene complement(179595..180347) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" downshifts complement(179619) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" CDS complement(180344..181354) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" gene complement(180344..181354) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" CDS complement(181347..182351) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" gene complement(181347..182351) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" CDS complement(182370..183323) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" gene complement(182370..183323) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" promotor_-35 182683..182689 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182704..182722 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182713 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(183354..183373) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(183361) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" CDS complement(183414..185003) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" gene complement(183414..185003) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" promotor_-10 complement(185044..185063) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(185056) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" promotor_-35 complement(185078..185085) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(185165) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" CDS complement(185194..186438) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" gene complement(185194..186438) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" downshifts complement(185215) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" CDS complement(186452..188380) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" gene complement(186452..188380) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" CDS complement(188408..189733) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" gene complement(188408..189733) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" CDS complement(189790..191157) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" gene complement(189790..191157) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" CDS complement(191183..192034) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" gene complement(191183..192034) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" CDS complement(192051..192965) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" gene complement(192051..192965) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" promotor_-10 complement(192996..193014) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193009) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" promotor_-35 complement(193030..193037) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(193075..193557) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" gene complement(193075..193557) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" CDS complement(193570..194025) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" gene complement(193570..194025) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" promotor_-10 complement(194051..194070) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(194072) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" promotor_-35 complement(194085..194086) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 194145..194152 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 194167..194186 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 194178 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" tRNA 194205..194279 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194205..194279 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" tRNA 194283..194358 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194283..194358 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" tRNA 194363..194435 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194363..194435 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" tRNA 194458..194542 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194458..194542 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" tRNA 194547..194621 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194547..194621 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" downshifts 194624 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" S_feature 194669..194786 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194787..194796 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194788 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" promotor_-10 194808..194823 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194849..195412 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" gene 194849..195412 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" CDS 195426..196052 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" gene 195426..196052 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" downshifts complement(195844) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(196002..196102) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 196032 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" upshifts complement(196042) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 196101..196108 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 196123..196142 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 196132..196212 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 196132 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" CDS 196213..197034 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" gene 196213..197034 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" CDS 197027..198478 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" gene 197027..198478 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" CDS 198497..199843 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" gene 198497..199843 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" downshifts 199838 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" promotor_-35 199862..199870 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199878 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" promotor_-10 199884..199903 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199930..199935 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199951..199970 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199957 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" misc_feature 200001..200017 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 200014 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" misc_RNA 200017..200187 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" gene 200017..200187 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" S_feature 200188..200276 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 200277..202079 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" gene 200277..202079 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" S_feature complement(201802..>202082) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 202065 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" SCAR join(202082,202128) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta4" N_region 202083..202127 /note="insertion of 45 bases of unknown origin" /modified_by="User" /label="Delta4" S_feature <202128..202246 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 202247..203224 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" gene 202247..203224 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" CDS 203226..203897 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" gene 203226..203897 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" promotor_-35 203791..203797 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203811..203830 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203829 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" CDS 203918..204880 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" gene 203918..204880 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" promotor_-35 204892..204894 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204910..204929 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 204913 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" CDS 204939..205202 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" gene 204939..205202 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" downshifts 205143 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" CDS complement(205187..205957) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" gene complement(205187..205957) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" CDS complement(206043..206900) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" gene complement(206043..206900) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" downshifts complement(206065) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" promotor_-10 complement(206114..206133) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(206147..206156) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(206149) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(206913..206932) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(206938) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" promotor_-35 complement(206947..206954) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 206968..206975 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 206989..207007 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 206991 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" CDS 207032..208216 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" gene 207032..208216 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" downshifts 208202 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" promotor_-35 208370..208376 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 208390..208409 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 208404..208533 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 208404 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" CDS 208534..209922 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" gene 208534..209922 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" downshifts 209930 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" promotor_-35 209968..209974 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 209988..209999 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 209989 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" CDS 210034..210282 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" gene 210034..210282 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" CDS 210299..210490 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" gene 210299..210490 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" downshifts 210472 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" CDS complement(210517..211320) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" gene complement(210517..211320) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" promotor_-10 complement(211342..211360) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(211350) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" promotor_-35 complement(211371..211379) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211434..211440 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211455..211473 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211461 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" CDS 211493..212746 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" gene 211493..212746 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" misc_feature 211805..211812 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 211815 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 212739 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" CDS complement(212787..213047) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" gene complement(212787..213047) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" downshifts complement(212806) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" promotor_-10 complement(213077..213095) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(213086) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" promotor_-35 complement(213109..213115) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 213239..213246 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 213256 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" promotor_-10 213262..213281 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 213316..214935 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" gene 213316..214935 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" downshifts 214918 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" CDS complement(214982..215863) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" gene complement(214982..215863) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" downshifts complement(214993) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" upshifts complement(215906) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" promotor_-10 complement(215915..215931) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(215940..215946) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(215962..217296) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" gene complement(215962..217296) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" promotor_-35 216944..216953 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 216966..217592 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 216966..216985 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216966 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" S_feature complement(217297..217369) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(217329..217429) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(217369) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" S_feature complement(217371..217457) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(217447..217466) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(217461) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" promotor_-35 complement(217479..217486) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 217593..217841 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" gene 217593..217841 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" promotor_-35 217865..217872 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 217872 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" promotor_-10 217888..217907 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 217933..218850 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" gene 217933..218850 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" CDS 218847..220097 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" gene 218847..220097 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" downshifts 220087 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" CDS complement(220132..220416) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" gene complement(220132..220416) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo downshifts complement(220185) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" CDS complement(220322..220444) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" gene complement(220322..220444) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo S_feature complement(220417..220537) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(220522..220540) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(220537) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" S_feature complement(220539..220611) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(220557..220562) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(220612..221523) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" gene complement(220612..221523) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" S_feature complement(221524..221611) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(221612..223810) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" gene complement(221612..223810) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" misc_feature complement(223845..223863) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(223857) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" CDS complement(223885..224805) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" gene complement(223885..224805) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" CDS complement(224802..225629) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " gene complement(224802..225629) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" misc_feature complement(225656..225675) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(225663) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" promotor_-35 225803..225806 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 225821..225840 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 225826 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" CDS 225860..227014 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" gene 225860..227014 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" downshifts 226995 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" promotor_-35 227075..227080 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-35" upshifts 227089 /Source="Nicolas_upshifts" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" promotor_-10 227095..227113 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-10" promotor_-35 227129..227136 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 227151..227170 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 227151 /Source="Nicolas_upshifts" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" CDS 227158..228099 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15205417, 15375126, 21819557, 25666135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular glutamyl-endopeptidase" /protein_id="NP_388106.1" /db_xref="EnsemblGenomes-Gn:BSU02240" /db_xref="EnsemblGenomes-Tr:CAB12018" /db_xref="GOA:P39790" /db_xref="InterPro:IPR000126" /db_xref="InterPro:IPR001254" /db_xref="InterPro:IPR008256" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR018114" /db_xref="InterPro:IPR028301" /db_xref="SubtiList:BG10690" /db_xref="UniProtKB/Swiss-Prot:P39790" /translation="MKLVPRFRKQWFAYLTVLCLALAAAVSFGVPAKAAENPQTSVSN TGKEADATKNQTSKADQVSAPYEGTGKTSKSLYGGQTELEKNIQTLQPSSIIGTDERT RISSTTSFPYRATVQLSIKYPNTSSTYGCTGFLVNPNTVVTAGHCVYSQDHGWASTIT AAPGRNGSSYPYGTYSGTMFYSVKGWTESKDTNYDYGAIKLNGSPGNTVGWYGYRTTN SSSPVGLSSSVTGFPCDKTFGTMWSDTKPIRSAETYKLTYTTDTYGCQSGSPVYRNYS DTGQTAIAIHTNGGSSYNLGTRVTNDVFNNIQYWANQ*" gene 227158..228099 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" CDS 228062..228460 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388107.1" /db_xref="EnsemblGenomes-Gn:BSU02250" /db_xref="EnsemblGenomes-Tr:CAB12019" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR019730" /db_xref="SubtiList:BG12739" /db_xref="UniProtKB/Swiss-Prot:O31451" /translation="MYSTIFNIGQINKYSKLAIFMSILFLCGCSSQTHSSQKETTIPV TLHVEDAKGLPVEGVQVTIVKAPSSDEEPSTEIGEILGKTDKNGDIKWDTGRKGDYSV ALTKGETSVTHHISLTEDKKDHAIPLVFKE*" gene 228062..228460 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" promotor_-10 complement(228154..228168) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(228164) /Source="Nicolas_upshifts" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(228184..228189) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 228447 /Source="Nicolas_upshifts" /id="D85" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.50775" /MaxDrop="5.06025" /score="29.4582027" /energy="-15.4" /TU="U156" /idTUdmin="U157" /TUdmin=0 /isTUend="TRUE" promotor_-35 228516..228523 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 228538..228557 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 228551..228625 /Source="Nicolas_S_feature" /locus_tag="new_246583_246657" /HighExp="Cold, LoTm, S0, aero, ferm, T-4.40H, nit, T-5.40H, T-0.40H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S87" upshifts 228551 /Source="Nicolas_upshifts" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" CDS 228626..229516 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /translation="MIQDSMQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKT HIIASGPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAME TRADFAEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFIS FHPDVYKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTEN GFPYVFTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLS LEQPEYVNQRVLSFLCGGIK*" gene 228626..229516 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" promotor_-35 228860..228867 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 228876 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" promotor_-10 228881..228899 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 229517..229711 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 229712..230245 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" gene 229712..230245 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" CDS 230236..230724 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" gene 230236..230724 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" CDS 230717..231508 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" gene 230717..231508 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" downshifts 231483 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" CDS 231563..231841 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" gene 231563..231841 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" promotor_-35 231884..231893 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 231902 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" promotor_-10 231906..231921 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 231947..233287 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" gene 231947..233287 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" downshifts 233287 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" upshifts 233353 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" misc_feature 233356..233375 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 233395..234282 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" gene 233395..234282 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" S_feature 234283..234426 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 234398..234405 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 234419..234438 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 234428 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" CDS 234482..235450 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" gene 234482..235450 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" promotor_-10 complement(235304..235322) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(235321) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(235338..235343) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 235447 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" downshifts complement(235486) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" CDS complement(235486..236730) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" gene complement(235486..236730) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" promotor_-10 complement(236764..236782) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236773) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" promotor_-35 complement(236793..236801) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(236801..236819) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236817) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" promotor_-35 complement(236835..236840) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(236875..238770) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" gene complement(236875..238770) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" downshifts complement(236891) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" misc_feature 238636..238655 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 238653 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(238791..239540) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" gene complement(238791..239540) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" S_feature 239513..239694 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(239541..239611) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(239600..239619) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(239615) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" promotor_-35 complement(239635..239642) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 239681..239688 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 239696 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" promotor_-10 239701..239720 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 239759..240466 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" gene 239759..240466 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" promotor_-35 240432..240433 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240449..240463 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240459 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" CDS 240500..240775 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" gene 240500..240775 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" promotor_-10 complement(240558..240576) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(240564) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(240591..240597) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 240767 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" promotor_-35 240818..240822 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240838..240857 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240844 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" S_feature 240855..240983 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 240984..242054 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" gene 240984..242054 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" downshifts 242043 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" CDS complement(242091..243503) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" gene complement(242091..243503) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" downshifts complement(242108) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" S_feature complement(243504..243615) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(243588..243607) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(243615) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" promotor_-35 complement(243622..243629) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(243624..244571) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" gene complement(243624..244571) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" promotor_-10 complement(244609..244628) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(244626) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" promotor_-35 complement(244643..244650) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(244700..246136) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" gene complement(244700..246136) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" downshifts complement(244715) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" CDS complement(246159..247142) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" gene complement(246159..247142) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" promotor_-10 complement(247236..247253) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 247241..247260 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(247243) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts 247247 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(247269..247276) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 247444..248676 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" gene 247444..248676 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" CDS 248687..249631 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" gene 248687..249631 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" downshifts 249608 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" promotor_-35 249728..249735 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 249740..249857 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 249740 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" promotor_-10 249749..249768 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 249858..250784 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" gene 249858..250784 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" CDS 250814..252280 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" gene 250814..252280 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" CDS 252364..253731 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" gene 252364..253731 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" CDS 253768..255135 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" gene 253768..255135 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" promotor_-35 255149..255156 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 255171..255188 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 255174 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" CDS 255205..255906 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" gene 255205..255906 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" downshifts 255856 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" downshifts 255900 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" CDS 255997..257529 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" gene 255997..257529 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" promotor_-35 257541..257544 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 257559..257578 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 257571..257805 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 257571 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" CDS 257806..258726 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" gene 257806..258726 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" promotor_-35 258728..258735 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 258750..258769 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 258760 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" misc_RNA 258783..259030 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" gene 258783..259030 /gene="tboW" /locus_tag="BSU_misc_RNA_6" downshifts 258999 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" CDS 259128..259289 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" gene 259128..259289 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" promotor_no_box 259206..259306 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 259266 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 259310..260248 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" gene 259310..260248 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" downshifts 259354 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" misc_feature 260271..260290 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 260276..260344 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 260276 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" CDS 260345..261025 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" gene 260345..261025 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" CDS 261027..261962 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" gene 261027..261962 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" CDS 262054..262977 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" gene 262054..262977 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" S_feature complement(262524..263708) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 262996..263682 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" gene 262996..263682 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" CDS complement(263643..263777) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" gene complement(263643..263777) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" downshifts 263677 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" CDS complement(263737..264123) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" gene complement(263737..264123) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" downshifts complement(263753) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(264149..264167) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264168) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" promotor_-35 complement(264181..264187) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(264201..265199) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(264244) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" promotor_-35 264380..264385 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 264399 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" promotor_-10 264401..264419 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264413) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" promotor_-10 complement(264415..264429) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(264435) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" promotor_-35 complement(264437..264441) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 264437..264865 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" gene 264437..264865 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" downshifts 264844 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" promotor_-35 264910..264916 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 264929..264948 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 264931 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" CDS 264971..265702 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" gene 264971..265702 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" promotor_-10 complement(265173..265192) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(265199) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" promotor_-35 complement(265206..265213) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 265620 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" CDS 265784..265960 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" gene 265784..265960 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" promotor_-35 265912..265918 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 265925..265942 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 265936 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" CDS 265979..267730 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" gene 265979..267730 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" promotor_-10 complement(266033..266048) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(266039) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(266061..266070) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 267743..267955 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" gene 267743..267955 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" S_feature 267956..268015 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 268016..268744 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" gene 268016..268744 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" downshifts complement(268024) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" CDS complement(268741..269388) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" gene complement(268741..269388) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" promotor_-10 complement(269403..269422) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 269416..269422 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(269417) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" promotor_-10 269437..269456 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(269437..269441) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 269439 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" CDS 269467..270579 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" gene 269467..270579 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" upshifts complement(269813) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(269816..269835) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(269851..269855) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 270573 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" CDS complement(270621..272060) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" gene complement(270621..272060) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" downshifts complement(270628) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" CDS complement(272100..272666) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" gene complement(272100..272666) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" promotor_-10 complement(272704..272723) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(272718) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" promotor_-35 complement(272738..272745) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 272820..272826 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 272842..272859 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 272848 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" CDS 272883..274010 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" gene 272883..274010 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" downshifts 273983 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" promotor_-35 274107..274113 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 274127..274146 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 274127 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" CDS 274173..274811 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" gene 274173..274811 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" downshifts 274797 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" S_feature 274842..275432 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(274849..275232) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" gene complement(274849..275232) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" downshifts complement(274873) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(275262..275281) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(275269) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" promotor_-35 complement(275295..275302) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 275404..275407 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 275423..275442 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 275434 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" CDS 275467..276543 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" gene 275467..276543 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" downshifts 276537 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" CDS complement(276583..277539) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" gene complement(276583..277539) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" downshifts complement(276611) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" CDS complement(277552..278253) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" gene complement(277552..278253) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" promotor_-10 complement(278277..278296) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(278283) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" promotor_-35 complement(278312..278315) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 278333..278336 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 278352..278371 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 278362 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" CDS 278397..279137 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" gene 278397..279137 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" CDS 279138..280298 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" gene 279138..280298 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" promotor_-35 280349..280357 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 280369..280387 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 280369 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" CDS 280434..281366 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" gene 280434..281366 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" CDS complement(281406..282470) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" gene complement(281406..282470) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" downshifts complement(281407) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" S_feature complement(282471..282661) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(282493..282624) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " gene complement(282493..282624) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" promotor_-10 complement(282646..282665) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282666) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" promotor_-35 complement(282680..282687) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 282798..284216 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" gene 282798..284216 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" promotor_-10 complement(284259..284277) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(284267) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(284291..284298) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 284323..284402 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 284323 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" promotor_-35 284325..284331 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 284346..284363 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 284403..285764 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" gene 284403..285764 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" S_feature 285765..286345 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(285772..286275) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" gene complement(285772..286275) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" S_feature complement(286276..286357) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 286347 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" promotor_-10 complement(286349..286368) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 286350..286369 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(286358) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" promotor_-35 complement(286381) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 286398..287519 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" gene 286398..287519 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" downshifts 287513 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" promotor_-35 287560..287566 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 287581..287599 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 287584 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" CDS 287626..288402 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" gene 287626..288402 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" downshifts complement(287633) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" CDS 288427..290112 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" gene 288427..290112 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" promotor_no_box 289367..289467 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 289427 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 289493 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" downshifts 290109 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" promotor_-35 290203..290210 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 290226..290245 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 290232 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" CDS 290300..291259 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" gene 290300..291259 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" promotor_-35 290855..290861 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 290875..290894 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 290879 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" downshifts 291231 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" CDS 291315..292010 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" gene 291315..292010 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" CDS 291968..292810 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" gene 291968..292810 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" downshifts 292797 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" CDS complement(292848..293843) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" gene complement(292848..293843) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" promotor_-35 293799..293806 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 293821..293840 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 293827..294029 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 293827 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" promotor_-10 complement(293875..293894) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(293883) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" promotor_-35 complement(293909..293916) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 294013..294022 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 294031..294126 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 294031 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" promotor_-10 294035..294050 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 294127..294726 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" gene 294127..294726 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" CDS 294748..295329 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" gene 294748..295329 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" CDS 295364..295942 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" gene 295364..295942 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" CDS 295993..296766 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" gene 295993..296766 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" downshifts 296753 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" CDS 296851..298464 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" gene 296851..298464 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" CDS 298480..299571 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" gene 298480..299571 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" downshifts 299545 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" promotor_-35 299625..299632 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 299647..299666 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 299655 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" CDS 299693..300895 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" gene 299693..300895 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" downshifts 300875 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" CDS complement(301148..302320) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" gene complement(301148..302320) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" downshifts complement(301163) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" CDS complement(302389..302691) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" gene complement(302389..302691) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" downshifts complement(302417) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" promotor_-10 complement(302674..302693) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(302693) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" promotor_-35 complement(302707..302713) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 302940..302959 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 302940 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" CDS 302981..304237 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" gene 302981..304237 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" downshifts complement(302989) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" CDS 304239..305087 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" gene 304239..305087 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" CDS 305087..305968 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" gene 305087..305968 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" downshifts 305949 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" downshifts complement(305981) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" CDS complement(306006..307157) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" gene complement(306006..307157) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" downshifts complement(306025) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" S_feature complement(307158..307245) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 307213..307220 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(307232..307251) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 307235..307254 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(307245) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" upshifts 307248 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" promotor_-35 complement(307264..307270) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 307307..308740 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" gene 307307..308740 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" promotor_-35 308045..308053 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308065..308083 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308084 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 308722 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" promotor_-35 308783..308790 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308805..308824 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308814 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" CDS 308856..309437 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" gene 308856..309437 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" upshifts 309250 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" misc_feature 309254..309258 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 309413..309420 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 309435..309454 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 309448..309585 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 309448 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" CDS 309586..311565 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" gene 309586..311565 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" downshifts 311579 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" promotor_-35 311645..311652 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 311662 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" promotor_-10 311666..311685 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 311742..312707 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" gene 311742..312707 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" CDS 312739..314364 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" gene 312739..314364 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" downshifts 312745 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" downshifts 314351 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" CDS complement(314409..315947) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" gene complement(314409..315947) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" downshifts complement(314427) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(315001..315101) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(315041) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 315961..315965 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 315981..316000 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 315995 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" promotor_-10 complement(316027..316046) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(316030) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" CDS 316060..316524 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" gene 316060..316524 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" promotor_-35 complement(316061..316067) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 316534..316539 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316555..316573 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316565 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" CDS 316598..317227 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" gene 316598..317227 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" promotor_-35 317238..317247 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 317261..317280 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 317269 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" CDS 317297..318058 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" gene 317297..318058 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" S_feature complement(317697..318059) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 318055 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" CDS complement(318060..319400) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" gene complement(318060..319400) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" promotor_-10 complement(319427..319438) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(319437) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" promotor_-35 complement(319453..319459) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 319479..319485 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 319493 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" promotor_-10 319500..319511 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 319530..320126 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" gene 319530..320126 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" promotor_-35 320134..320141 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 320155..320255 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 320155..320174 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 320155 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" downshifts complement(320251) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" CDS 320256..321074 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" gene 320256..321074 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" downshifts 321056 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" CDS complement(321124..321717) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" gene complement(321124..321717) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" downshifts complement(321131) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" promotor_-10 complement(321732..321751) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(321747) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(321766..321769) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(321775..321923) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 321825..321832 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 321845..321864 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 321847..321955 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 321849 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" promotor_-10 complement(321917..321935) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 321923..321930 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(321933) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" promotor_-10 321945..321964 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(321951..321956) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 321957 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" CDS 321993..322553 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" gene 321993..322553 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" downshifts 322530 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" CDS complement(322581..323342) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" gene complement(322581..323342) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" downshifts complement(322605) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(323374..323393) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 323375..323382 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(323380) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" promotor_-10 323397..323416 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(323408..323413) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 323409 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" CDS 323460..324434 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" gene 323460..324434 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" S_feature 324435..324505 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 324506..325462 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" gene 324506..325462 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" promotor_-35 324921..324927 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 324942..324953 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 324949 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" S_feature 325463..325541 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 325516..325521 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 325538..325556 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 325543 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" CDS 325546..326328 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" gene 325546..326328 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" downshifts 326293 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" S_feature 326338..326465 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 326442..326446 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326461..326480 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326467 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" CDS 326519..327430 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" gene 326519..327430 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" CDS 327447..328994 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" gene 327447..328994 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" promotor_-35 328418..328424 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328438..328457 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328446 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" promotor_-35 328529..328535 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328548..328567 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328557 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" misc_feature 328993..328997 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 328995..329117 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 328997 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" CDS 329118..330539 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" gene 329118..330539 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" S_feature complement(329638..331493) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 330519 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" S_feature 330564..330660 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 330631..330638 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 330653..330672 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 330662 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" CDS 330692..331927 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" gene 330692..331927 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" promotor_-10 complement(331486..331504) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(331503) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" promotor_-35 complement(331518..331525) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(331911) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" CDS complement(331964..332821) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" gene complement(331964..332821) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" downshifts complement(331977) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" CDS complement(332826..333710) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" gene complement(332826..333710) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" upshifts complement(333762) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" promotor_-10 complement(333767..333780) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(333795..333803) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(333810..334664) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" gene complement(333810..334664) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" promotor_-10 complement(334683..334702) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(334703) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" promotor_-35 complement(334717..334720) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 334754..334773 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(334754..334772) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 334761..334825 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 334762 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" upshifts complement(334771) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(334788..334793) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 334826..335836 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" gene 334826..335836 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" S_feature 335837..338284 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(335868..337319) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" gene complement(335868..337319) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" downshifts complement(335872) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" CDS complement(337380..337700) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" gene complement(337380..337700) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" promotor_-35 337551..337556 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 337570..337574 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 337577 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(337609) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" promotor_-10 complement(337611..337630) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(337644..337651) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(337732..340149) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" gene complement(337732..340149) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" promotor_-10 complement(340174..340193) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(340188) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" promotor_-35 complement(340205..340211) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(340271..342403) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" gene complement(340271..342403) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" CDS complement(342410..344725) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" gene complement(342410..344725) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" promotor_no_box complement(344744..344844) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(344784) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" promotor_-35 344827..344834 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 344848..344867 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 344860 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" CDS 344905..346110 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" gene 344905..346110 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" downshifts 346095 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" promotor_-35 346154..346160 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 346175..346194 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 346183 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" CDS 346227..347141 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" gene 346227..347141 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" CDS 347138..347722 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" gene 347138..347722 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" promotor_-35 347733..347740 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 347754..347773 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 347764 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" CDS 347818..348003 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" gene 347818..348003 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" CDS 348031..349224 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" gene 348031..349224 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" downshifts 349216 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" S_feature 349261..350930 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(349273..349953) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" gene complement(349273..349953) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" downshifts complement(349279) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" CDS complement(349963..350826) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" gene complement(349963..350826) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" promotor_-10 complement(350848..350867) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(350860) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" S_feature complement(350862..353696) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(350882..350889) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 350899..350905 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350920..350938 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 350932..351154 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 350932 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" CDS 350988..351185 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" gene 350988..351185 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" promotor_-35 351123..351128 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 351144..351162 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 351156 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" CDS 351204..351659 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" gene 351204..351659 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" downshifts 351634 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" promotor_-35 351682..351688 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 351695 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" promotor_-10 351702..351713 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 351741..352073 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" gene 351741..352073 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" downshifts 352054 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" promotor_-35 352159..352166 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 352182..352201 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 352186 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" CDS 352227..353660 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" gene 352227..353660 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" downshifts 353638 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" CDS complement(353697..354095) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" gene complement(353697..354095) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" promotor_no_box complement(354092..354192) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(354122..354571) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" gene complement(354122..354571) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" upshifts complement(354132) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" promotor_-10 complement(354586..354605) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(354594) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" S_feature complement(354596..354738) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(354619..354626) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(354739..356460) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" gene complement(354739..356460) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" promotor_-35 354751..354758 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 354769..357912 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 354769 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" promotor_-10 354773..354792 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(354774..354874) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(354814) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" promotor_-10 complement(356484..356502) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(356499) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" promotor_-35 complement(356516..356523) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(356571..357128) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" gene complement(356571..357128) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" downshifts complement(356574) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" CDS complement(357134..357766) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" gene complement(357134..357766) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" promotor_-10 complement(357792..357811) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(357807) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" promotor_-35 complement(357826..357829) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 357890..357893 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 357908..357927 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 357914 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" CDS 358000..358362 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" gene 358000..358362 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" downshifts 358346 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" promotor_-35 358609..358612 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 358627..358646 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 358635..358935 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 358635 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" CDS 358936..369699 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" gene 358936..369699 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" CDS 369712..380463 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" gene 369712..380463 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" CDS 372848..372988 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" gene 372848..372988 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" CDS 380500..384327 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" gene 380500..384327 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" CDS 384356..385084 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" gene 384356..385084 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" downshifts 385066 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" promotor_-35 385122..385129 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 385132 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" promotor_-10 385141..385160 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 385185..386411 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" gene 385185..386411 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" downshifts 386405 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" CDS complement(386426..386983) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" gene complement(386426..386983) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" promotor_no_box complement(386441..386541) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(386463) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" upshifts complement(386481) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(387012..387031) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(387014) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" CDS complement(387037..387975) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" gene complement(387037..387975) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" promotor_-10 complement(388014..388032) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(388021) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(388048..388053) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 388099..389433 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" gene 388099..389433 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" CDS complement(389428..389595) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" gene complement(389428..389595) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo CDS complement(389606..390103) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" gene complement(389606..390103) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo misc_feature complement(390130..390149) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(390142) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" CDS complement(390208..390855) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" gene complement(390208..390855) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" promotor_-10 complement(390884..390903) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(390887) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" promotor_-35 complement(390919..390923) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(391024..391175) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(391176..391919) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" gene complement(391176..391919) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" downshifts complement(391232) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" CDS complement(391933..392637) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" gene complement(391933..392637) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" CDS complement(392624..393430) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" gene complement(392624..393430) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" promotor_-10 complement(393479..393498) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393491) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" promotor_-35 complement(393512..393519) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(393546..394418) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" gene complement(393546..394418) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" promotor_-10 complement(394156..394174) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(394163) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" promotor_-35 complement(394189..394195) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 394472..394479 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(394487..394506) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 394493..394512 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(394493) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" upshifts 394501 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" CDS 394508..395122 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" gene 394508..395122 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" promotor_-35 complement(394520..394527) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 395125..396546 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" gene 395125..396546 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" CDS 396563..396790 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" gene 396563..396790 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" CDS 396787..397251 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" gene 396787..397251 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" downshifts 397232 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" misc_feature 397258..397259 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 397259 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 397318..398163 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" gene 397318..398163 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" CDS complement(398203..399681) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" gene complement(398203..399681) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" downshifts complement(398211) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" promotor_-35 399708..399710 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(399709..399728) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399719 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 399727..399745 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399729) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" S_feature complement(399731..400235) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(399743..399750) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 399899..399908 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 399921..399940 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399922 /Source="Nicolas_upshifts" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" CDS 399961..401715 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative uronase" /protein_id="NP_388250.1" /db_xref="EnsemblGenomes-Gn:BSU03680" /db_xref="EnsemblGenomes-Tr:CAB12176" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG12028" /db_xref="UniProtKB/Swiss-Prot:P94409" /translation="MAEFILNAADFGVPRDGKTDSTERINQCLSTAVSKGYHTVWFPK GTYLIDATLGGDLNQRFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQEN ITISGGQIIGERDEHTYASAGIRSTHEWGFGICIEGCSNVVIDDVKISDFTGDGIIVS PRGLKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPK FGIDIEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYG YGTQTVIKGNILRRPEDAAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRG KSVLVTNNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDIAFLN NCLIQVVDGVNVSGGNMIIKDNLLRKFSRGIWIAQGNAVIEGNTLNPDAFEAVPESYS VSVTNNAGAIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIF DNTISVNRTAGNPIVIYLNGSAGSIISGNTINNLSAGTATAIQTNTSTNSKIIGNRIF KGTINKHSSDTIDGNMIV*" gene 399961..401715 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" promotor_-10 complement(400232..400250) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(400245) /Source="Nicolas_upshifts" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" promotor_-35 complement(400266..400271) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 401706 /Source="Nicolas_upshifts" /id="D160" /incds=0 /nref=6 /ntot=21 /MaxReadThrough="0.325519999999999" /MaxDrop="4.9689" /score="4.29139266" /energy="-5.4" /TU="NA" /idTUdmin="U282" /TUdmin=7 /isTUend="TRUE" CDS complement(401731..401952) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388251.1" /db_xref="EnsemblGenomes-Gn:BSU03690" /db_xref="EnsemblGenomes-Tr:CAB12177" /db_xref="GOA:O31479" /db_xref="SubtiList:BG12780" /db_xref="UniProtKB/Swiss-Prot:O31479" /translation="MKILGVTGFILICLLAISVLMDMLQGFSLTKAVYNNMSSFKMTT FAEWVVLLFFVLVLVREMYVIYKSKKKNP*" gene complement(401731..401952) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" promotor_-10 complement(401971..401982) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(401973) /Source="Nicolas_upshifts" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" promotor_-35 complement(401997..402003) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 402018..402024 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 402038..402049 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 402051 /Source="Nicolas_upshifts" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" CDS 402078..403712 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388252.1" /db_xref="EnsemblGenomes-Gn:BSU03700" /db_xref="EnsemblGenomes-Tr:CAB12178" /db_xref="GOA:P49939" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG11392" /db_xref="UniProtKB/Swiss-Prot:P49939" /translation="MPLFSKRKNNTDSKDKQNTDERNQEQQQEKERPVLISPSLAKNI AETKKEVGSSSDVIIREIKIGEQDHVHLAVIYISGLVDNNTIHESLIDPLVQDESIQN THAIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGHDEALICSTQGGEQRSI QEPSTQVSFRGPRQGFTESLQTNISMIRRYIKNPNLWVEKMKKGSVTNTDIALMYIQG ICDEKVLKEVKQRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLE GRFAIIVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLVFFISLVAPAVY VAATTFHQEMIPTQLLVVIAAQREIVPFPAVVEALTMEVAFEILREAGVRLPRVVGSA VSIVGALVIGQAAVQAGIVSPAMVIIVALTAIASFATPAFAMAISARLIRFIFIIASA VMGFYGLILGIIMMFVHLCSLRSFGVPYMSPLAPFSSQGVKDALFRVPWWADEKRPES VSKEDKVRQGKDQRPEPAASRGMVNKDLEEGDQNGT*" gene 402078..403712 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" CDS 403702..404925 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944, 19363077; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388253.1" /db_xref="EnsemblGenomes-Gn:BSU03710" /db_xref="EnsemblGenomes-Tr:CAB12179" /db_xref="GOA:P49941" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG11394" /db_xref="UniProtKB/Swiss-Prot:P49941" /translation="MVRKCLLAVLMLLSVIVLPGCWDKRELTDLAIISAIGIDRTNDS NYVLHLQIINPGNVAGGLQGGGAGDRPPVSVYSIEGNNITEALRKASMKVSRRLYFAH TNLVVINEKLAKEEGLDFVLDNLDRDTEFRTTATFVVAHKTKAENIVKILTPIDKIPS NKVNKTLDFTEAQYGRVVKINIQDVLKTLAANTMAPVIPGYMMIGDDKKGVSMENTQA TDPKAILQADGLAVFDKAGYLKYWLEDDESVGAVWLMNKIQHTFINADWGKTKDAVSL QVTHQDTKLVPKMRNGRPYIHVKVSVEGIIDAVKYPFQLSDPKVLAAIEKALNKELEK EISHTVKKIKKNKIDFIGFGDTIYRKYPEQWEKMKDTWDKEYLPELPIDVKAETYIRR TGLRNNPIKHQFKDD*" gene 403702..404925 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" CDS 404950..406071 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 15849754, 16707705, 16740944, 16850406, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 15849754, 16707705, 16740944, 16850406, 19363077; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388254.1" /db_xref="EnsemblGenomes-Gn:BSU03720" /db_xref="EnsemblGenomes-Tr:CAB12180" /db_xref="GOA:P49940" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG11393" /db_xref="UniProtKB/Swiss-Prot:P49940" /translation="MEKARISIRQLFVMIIIFELGSSLLITPGSMAGRDAWIAVLLGC AIGLFLFYLYQGIYQCYPNSSPKEYMDDMLGTKLSWLFSFLYILYFAYIAARVLRDFG EMLLTFAYHDTPIIIVNALLMVVSIYAVRKGIEVLARAAELLFGAMYLLGAIGLVLII VSGTIDPHNLKPVLANGISPVLHSVFTQTMYVPFGEVVLFVMIFPNLNDRKDVKKMGM IAMAISGLIVALTVAINISVLDVDLTLRSQFPLLSTIQTIKVEEFLDRLDVFFMLALI IGGFFKVSLYLYATVVGTSTLFKEKNPSQLAYPMGLGILILSITIATNFSEHLNEGLN VVPLYIHLPFQLLFPLFLFIVAVWKKKRREKSKGEEAKK*" gene 404950..406071 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" downshifts 406055 /Source="Nicolas_upshifts" /id="D161" /incds=0 /nref=6 /ntot=58 /MaxReadThrough="2.55658" /MaxDrop="3.73002" /score="3.39927899" /energy="-10.5" /TU="NA" /idTUdmin="U285" /TUdmin=2200 /isTUend="FALSE" CDS complement(406176..406856) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATPase component)" /protein_id="NP_388255.1" /db_xref="EnsemblGenomes-Gn:BSU03730" /db_xref="EnsemblGenomes-Tr:CAB12181" /db_xref="GOA:P94411" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12029" /db_xref="UniProtKB/Swiss-Prot:P94411" /translation="MSLLQFQQVGYWYKNKSQPLFQDINISFQKGKFYTIVGTSGTGK TTFLSLAGGLDAPKEGNILYDGKAVSKIGLTNFRNQYVSIVFQAYNLLPYMTALQNVT TAMEITGSKEKNKESYALDMLQKVGINEKQARQKVLTLSGGQQQRVSITRAFCCDTDL IVADEPTGNLDEDTSKEIVRLFQDLAHKEDKCVIMVTHDEQIAKVSDINIRLSRGSFT VKENVAVV*" gene complement(406176..406856) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" CDS complement(406872..408332) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388256.2" /db_xref="EnsemblGenomes-Gn:BSU03740" /db_xref="EnsemblGenomes-Tr:CAB12182" /db_xref="GOA:P94412" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG12030" /db_xref="UniProtKB/Swiss-Prot:P94412" /translation="MNFIKRAFWNMKAKKGKTLLQLFVFTVICVFVLSGLAIQSAAQK SSELARQELGGSVTLQVDRQKQMEKQQDSGEKRSFESTPIKVSDANKLAALDHVKSYN YTTSASANAGNFDAIESSSSSDSSSSSSSSNAKNSQGGGQGGPQMVQADLSIEGVIST ALVDDFSDGDSKITDGRAITKSDVGKKVTVINETLAEENDLSVGDSITIESATDEDTT VKLKIVGIYKTTSSGDDQAQNFSFLNPYNKLYTPYTATAALKGDDYKNTIDSAVYYMD DAKNMDTFVKAAKKTSIDFDTYTLNTNDQLYQQMVGPIENVASFSKNVVYLVSVAGAV ILGLIVMMSIRERKYEMGVLMAIGEKRWKLIGQFLTEILIVAVIAIGLASVTGNLVAN QLGNQLLSQQISSSTDSTQTASGQMPGGGGGMGGKMFGHSSSNVDVIDSLNVAVSMND MLILGGIGILIAIIATLLPSISVLRLHPKTILTKQE*" gene complement(406872..408332) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" misc_feature 408502..408521 /Source="Nicolas_upshift_promotors" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 408505 /Source="Nicolas_upshifts" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" CDS 408545..409228 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /function="16.10: Respire" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YclK] (possibly involved in arabinogalactan metabolism)" /protein_id="NP_388257.1" /db_xref="EnsemblGenomes-Gn:BSU03750" /db_xref="EnsemblGenomes-Tr:CAB12183" /db_xref="GOA:P94413" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12031" /db_xref="UniProtKB/Swiss-Prot:P94413" /translation="MKILMIEDNVSVCTMTEMFFFKEGFEAEFVHDGLEGYQRFTEEN WDLIILDIMLPSMDGVTICRKIRETSTVPIIMLTAKDTESDQVIGFEMGADDYVTKPF SPLTLVARIKAVIRRYKATGKAVIDEDMIETECFTINKKTREVLLNGEPVENLTPKEF DLLYYLVQNPRQVFSREQLLEQVWGYQFYGDERTVDVHIKRLRKKLASEDKPFLYTVW GVGYKFDED*" gene 408545..409228 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" CDS 409215..410636 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /function="16.3: Control" /function="16.10: Respire" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YclJ]" /protein_id="NP_388258.1" /db_xref="EnsemblGenomes-Gn:BSU03760" /db_xref="EnsemblGenomes-Tr:CAB12184" /db_xref="GOA:P94414" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12032" /db_xref="UniProtKB/Swiss-Prot:P94414" /translation="MMKIKYLYQLLLSHISILILAFVIIISLFSHFVKEFAYQNKVEE LTSYAVQIANEFQSGQVDMRRLYPYQDILSTRKTQFIIFNEEQQPYFLPEGFHHPPRE QLKKSEWNKLKKGQTVTIRADGRFDDEVSLVAQPIFVQNEFKGAVLLISPISGVEQMV NQVNLYMFYAVISTLVITILVSWLLSKFHVKRIQKLREATDKVASGDYDIHLENSYGD EIGVLASDFNIMAKKLKQSRDEIERLEKRRRQFIADVSHELKTPLTTINGLVEGLNSH TIPEDKKDKCFSLISEETKRMLRLVKENLDYEKIRSQQITLNKLDVPLIEVFEIVKEH LQQQAEEKQNKLMIQVEDHVIVHADYDRFIQILVNITKNSIQFTQNGDIWLRGMEGYK ETIIEIEDTGIGIPKEDIEHIWERFYKADISRTNTAYGEYGLGLSIVRQLVEMHQGTV EIKSEEGKGTKFIIRLPLTAKQQ*" gene 409215..410636 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" downshifts 410612 /Source="Nicolas_upshifts" /id="D162" /incds=0 /nref=20 /ntot=169 /MaxReadThrough="3.43905" /MaxDrop="4.91565" /score="13.4599201" /energy="-15" /TU="U286" /idTUdmin="U286" /TUdmin="-1427" /isTUend="FALSE" S_feature 410657..410761 /Source="Nicolas_S_feature" /locus_tag="new_428689_428793" /HighExp="Lbstat, nit, ferm, BI, M0t45, M40t45, M0t90, S0, S2, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S129" misc_feature 410751..410770 /Source="Nicolas_upshift_promotors" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 410763 /Source="Nicolas_upshifts" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" downshifts complement(410795) /Source="Nicolas_upshifts" /id="D163" /incds=0 /nref=2 /ntot=81 /MaxReadThrough="1.74985" /MaxDrop="4.10695" /score="1.47729412" /energy="-10.3" /TU="NA" /idTUdmin="U290" /TUdmin=1320 /isTUend="FALSE" CDS 410799..411947 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 15968044, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 15968044, 19202088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388259.1" /db_xref="EnsemblGenomes-Gn:BSU03770" /db_xref="EnsemblGenomes-Tr:CAB12185" /db_xref="GOA:P94415" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11966" /db_xref="UniProtKB/Swiss-Prot:P94415" /translation="MKSGVIPSSAVGQKINEWYRYIRTFSVPDAEVLKAEIQQELKHM QHDSNLLLYYSLMEFRHQLMLDYLEPLEKLNIEDQPSLSELSRNIDSNQADLKGLLDY YVNFFRGMYEFDKREFISAITYYKQAEKKLSFVADHIERAEFYFKIAEAYYYMKQTYF SLINIKNAYEIYVEQETYNVRIIQCHFVFGVNLMDERNFEQAARHFKLALNMAQAEQK AQLVGRAYYNLGLCYYNQDLLDPAIDYFEKAVSTFESSRIVNSLPQAYFLITLIYYKQ GKHDKASEYHKRGYEYAKETDDADYAVKFEFLQSLYLDQPNEEGIERCFQYLKNKNMY ADIEDLALEVAKYYYEQKWFKLSASYFLQVEEARKQIQRSEGLYEIEI*" gene 410799..411947 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" promotor_-35 411647..411652 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 411665 /Source="Nicolas_upshifts" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" promotor_-10 411669..411687 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 411809..411817 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 411829..411847 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411841 /Source="Nicolas_upshifts" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" CDS 411931..412053 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 16816200, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 16816200, 19202088; Product type r : regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapC and competence and sporulation stimulating factor (CSF)" /protein_id="NP_388260.1" /db_xref="EnsemblGenomes-Gn:BSU03780" /db_xref="EnsemblGenomes-Tr:CAB12186" /db_xref="GOA:P94416" /db_xref="InterPro:IPR020243" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11959" /db_xref="UniProtKB/Swiss-Prot:P94416" /translation="MKLKSKLFVICLAAAAIFTAAGVSANAEALDFHVTERGMT*" gene 411931..412053 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" downshifts 412040 /Source="Nicolas_upshifts" /id="D164" /incds=0 /nref=260 /ntot=275 /MaxReadThrough="3.24518" /MaxDrop="7.70367" /score="26.3182765" /energy="-14" /TU="NA" /idTUdmin="U286" /TUdmin=1 /isTUend="TRUE" downshifts complement(412108) /Source="Nicolas_upshifts" /id="D165" /incds=0 /nref=3 /ntot=64 /MaxReadThrough="0.60499" /MaxDrop="7.4475" /score="-1.25354129" /energy="-15.8" /TU="NA" /idTUdmin="U290" /TUdmin=7 /isTUend="TRUE" CDS complement(412153..412242) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097676.1" /db_xref="EnsemblGenomes-Gn:BSU03788" /db_xref="EnsemblGenomes-Tr:CAX52547" /db_xref="GOA:C0H3V0" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V0" /translation="MSGYGTSFALIVVLFILLIIVGTAFVGGY*" gene complement(412153..412242) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" downshifts complement(412313) /Source="Nicolas_upshifts" /id="D166" /incds=0 /nref=25 /ntot=113 /MaxReadThrough="7.05273" /MaxDrop="3.3619" /score="32.1465401" /energy="-16.5" /TU="U290" /idTUdmin="U290" /TUdmin="-198" /isTUend="FALSE" CDS complement(412324..412437) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore and germination protein" /protein_id="YP_003097677.1" /db_xref="EnsemblGenomes-Gn:BSU03789" /db_xref="EnsemblGenomes-Tr:CAX52548" /db_xref="GOA:C0H3V1" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V1" /translation="MSGYSNGGGYGGISSFALIVVLFILLIIVGTAFVGGF*" gene complement(412324..412437) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" promotor_-10 complement(412458..412477) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(412469) /Source="Nicolas_upshifts" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" promotor_-35 complement(412490..412499) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(412591..413955) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2152900, 11471740, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2152900, 11471740, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate kinase III" /protein_id="NP_388261.1" /db_xref="EnsemblGenomes-Gn:BSU03790" /db_xref="EnsemblGenomes-Tr:CAB12187" /db_xref="GOA:P94417" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR035804" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12033" /db_xref="UniProtKB/Swiss-Prot:P94417" /translation="MKVVKFGGSSLASGAQLDKVFHIVTSDPARKAVVVSAPGKHYAE DTKVTDLLIACAEQYLATGSAPELAEAVVERYALIANELQLGQSIIEKIRDDLFTLLE GDKSNPEQYLDAVKASGEDNNAKLIAAYFRYKGVKAEYVNPKDAGLFVTNEPGNAQVL PESYQNLYRLRERDGLIIFPGFFGFSKDGDVITFSRSGSDITGSILANGLQADLYENF TDVDAVYSVNPSFVENPKEISELTYREMRELSYAGFSVFHDEALIPAFRAGIPVQIKN TNNPSAEGTRVVSKRDNTNGPVVGIASDTGFCSIYISKYLMNREIGFGRRALQILEEH GLTYEHVPSGIDDMTIILRQGQMDAATERSVIKRIEEDLHADEVIVEHHLALIMVVGE AMRHNVGTTARAAKALSEAQVNIEMINQGSSEVSMMFGVKEAEERKAVQALYQEFFAG VLIS*" gene complement(412591..413955) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" downshifts complement(412599) /Source="Nicolas_upshifts" /id="D167" /incds=0 /nref=23 /ntot=129 /MaxReadThrough="2.21842" /MaxDrop="4.81019" /score="44.9085917" /energy="-15" /TU="NA" /idTUdmin="U291" /TUdmin=0 /isTUend="TRUE" downshifts complement(412643) /Source="Nicolas_upshifts" /id="D168" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="5.53807" /MaxDrop="2.54279" /score="44.9085917" /energy="-15" /TU="U291" /idTUdmin="U291" /TUdmin="-44" /isTUend="FALSE" promotor_-10 complement(413991..414010) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(414007) /Source="Nicolas_upshifts" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" promotor_-35 complement(414025..414032) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 414146..414150 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 414166..414185 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 414178 /Source="Nicolas_upshifts" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" promotor_-35 414209..414216 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 414230..414249 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 414239..414339 /Source="Nicolas_S_feature" /locus_tag="new_432271_432371" /HighExp="LBGexp, Lbexp, G150, dia0, G135, H2O2, Paraq, dia15, G180, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S130" upshifts 414239 /Source="Nicolas_upshifts" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" CDS 414340..415290 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388262.1" /db_xref="EnsemblGenomes-Gn:BSU03800" /db_xref="EnsemblGenomes-Tr:CAB12188" /db_xref="GOA:P94418" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12034" /db_xref="UniProtKB/Swiss-Prot:P94418" /translation="MKLRYLFILLIILAVTSVFIGVEDLSPLDLFDLSKQEASTLFAS RLPRLISIVIAGLSMSICGLIMQQISRNKFVSPTTAGTMDWARLGILISLLLFTSASP LIKMLVAFVFALAGNFLFMKILERIKFNDTIFIPLVGLMLGNIVSSIATFIAYKYDLI QNVSSWLQGDFSLVVKGRYELLYLSIPLVIIAYVYADKFTLAGMGESFSVNLGLKYKR VVNIGLIIVSLITSLVILTVGMLPFLGLIIPNIVSIYRGDNLKSSLPHTVLLGAVFVL FCDILGRIIIFPYEISIGLMVGIIGSGIFLFMLLRRKAYA*" gene 414340..415290 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" CDS 415283..416230 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388263.1" /db_xref="EnsemblGenomes-Gn:BSU03810" /db_xref="EnsemblGenomes-Tr:CAB12189" /db_xref="GOA:P94419" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12035" /db_xref="UniProtKB/Swiss-Prot:P94419" /translation="MRNQMKIALLVGLAIVCIGLFLFYDLGNWDYTLPRRIKKVAAIV LTGGAIAFSTMIFQTITNNRILTPSILGLDSLYMLIQTGIIFLFGSANMVIMNKNINF IISVLLMILFSLVLYQIMFKGEGRNIFFLLLIGIVFGTLFSSLSSFMQMLIDPNEFQV VQDKMFASFNNINTDLLWLAFIIFLLTGVYVWRFTKFFDVLSLGREHAVNLGIDYDKV VKQMLIVVAILVSVSTALVGPIMFLGLLVVNLAREFLKTYKHSYLIAGSVFISIIALV GGQFVVEKVFTFSTTLSVIINFAGGIYFIYLLLKENKSW*" gene 415283..416230 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" CDS 416224..416982 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (ATP-binding protein)" /protein_id="NP_388264.1" /db_xref="EnsemblGenomes-Gn:BSU03820" /db_xref="EnsemblGenomes-Tr:CAB12190" /db_xref="GOA:P94420" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12036" /db_xref="UniProtKB/Swiss-Prot:P94420" /translation="MVEVRNVSKQYGGKVVLEETSVTIQKGKITSFIGPNGAGKSTLL SIMSRLIKKDSGEIYIDGQEIGACDSKELAKKMSILKQANQINIRLTIKDLVSFGRFP YSQGRLTEEDWVHINQALSYMKLEDIQDKYLDQLSGGQCQRAFIAMVIAQDTDYIFLD EPLNNLDMKHSVEIMKLLKRLVEELGKTIVIVIHDINFASVYSDYIVALKNGRIVKEG PPEEMIETSVLEEIYDMTIPIQTIDNQRIGVYFS*" gene 416224..416982 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" CDS 417004..417957 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416, 25355936; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (binding lipoprotein)" /protein_id="NP_388265.1" /db_xref="EnsemblGenomes-Gn:BSU03830" /db_xref="EnsemblGenomes-Tr:CAB12191" /db_xref="GOA:P94421" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR033870" /db_xref="PDB:3GFV" /db_xref="SubtiList:BG12037" /db_xref="UniProtKB/Swiss-Prot:P94421" /translation="MKKFALLFIALVTAVVISACGNQSTSSKGSDTKKEQITVKHQLD KNGTKVPKNPKKVVVFDFGSLDTLDKLGLDDIVAGLPKQVLPKYLSKFKDDKYADVGS LKEPDFDKVAELDPDLIIISARQSESYKEFSKIAPTIYLGVDTAKYMESFKSDAETIG KIFDKEDKVKDELANIDHSIADVKKTAEKLNKNGLVIMANDGKISAFGPKSRYGLIHD VFGVAPADQNIKASTHGQSVSYEYISKTNPDYLFVIDRGTAIGETSSTKQVVENDYVK NVNAVKNGHVIYLDSATWYLSGGGLESMTQMIKEVKDGLEK*" gene 417004..417957 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" downshifts 417940 /Source="Nicolas_upshifts" /id="D169" /incds=0 /nref=161 /ntot=280 /MaxReadThrough="3.87669" /MaxDrop="7.4722" /score="31.9942335" /energy="-13.8" /TU="U293" /idTUdmin="U292" /TUdmin=5 /isTUend="TRUE" CDS complement(418004..419422) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15855514, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388266.1" /db_xref="EnsemblGenomes-Gn:BSU03840" /db_xref="EnsemblGenomes-Tr:CAB12192" /db_xref="GOA:P94422" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12038" /db_xref="UniProtKB/Swiss-Prot:P94422" /translation="MNTSIEQKPFNRSVIVGILLAGAFVAILNQTLLITALPHIMRDF NVDANQAQWLTTSFMLTNGILIPITAFLIEKFTSRALLITAMSIFTAGTVVGAFAPNF PVLLTARIIQAAGAGIMMPLMQTVFLTIFPIEKRGQAMGMVGLVISFAPAIGPTLSGW AVEAFSWRSLFYIILPFAVIDLILASILMKNVTTLRKTQIDILSVILSTFGFGGLLYG FSSVGSYGWSSSTVLISLLVGVIALLLFITRQMKLKKPMLEFRVFTFGVFSLTTLLGT LVFALLIGTETILPLYTQNVRDVTAFDTGLMLLPGAVVMGFMSPIIGRIFDRVGGRGL AIAGFCIIFLTSLPFMQLTDHTSLAWIVVLYTVRLLGTAMIMMPVTTAGINALPRHLI PHGTAMNNTIRQVGGSIGTALLVSVMSNQAAHAGTTNVKHAALHGMNAAFIVAAVIAL VGFLLSFTLKKPQRPAEQQPAR*" gene complement(418004..419422) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" downshifts complement(418025) /Source="Nicolas_upshifts" /id="D170" /incds=0 /nref=8 /ntot=150 /MaxReadThrough="2.00954" /MaxDrop="5.13029" /score="17.5501827" /energy="-13.8" /TU="NA" /idTUdmin="U294" /TUdmin="-14" /isTUend="TRUE" CDS complement(419442..420320) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388267.2" /db_xref="EnsemblGenomes-Gn:BSU03850" /db_xref="EnsemblGenomes-Tr:CAB12193" /db_xref="GOA:P94423" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12039" /db_xref="UniProtKB/Swiss-Prot:P94423" /translation="MLDKKTDILLAARKLFSEKDFTSVSMQAIAEECKMSKASIYKLF QSKEDLLLELLSFNQKQMVAAASRLQENTALTPEERLTQKVKMELEGFRRNQQFFNML TYGNPKLHNDRVKQHIHQTRSTIICWHRDSLIQAYGETILPFVWDLVIILHGMMREFL MLIKIEEKPLELDPIAEFIISTLNQIIKNRETRQSLLPPEAIELYIHSASSYKPKDKS VLLSESLKELHKGISSLSAADYDVDELTSAAAMLEEEAKKEEPRAFLLKSLIGYLEQT GVLTQPVSMLKTLLIT*" gene complement(419442..420320) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" S_feature complement(420321..420387) /Source="Nicolas_S_feature" /locus_tag="new_438353_438419_c" /HighExp="dia15, H2O2, Diami, Paraq, Oxctl, Cold, G180, Salt, BMM, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S131" promotor_-10 complement(420386..420405) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(420395) /Source="Nicolas_upshifts" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" promotor_-35 complement(420420..420426) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(420484..421233) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /EC_number="1.5.1.39" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16229462, 9836433, 20862523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16229462, 9836433, 20862523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-FMN oxidoreductase (nitroreductase)" /protein_id="NP_388268.1" /db_xref="EnsemblGenomes-Gn:BSU03860" /db_xref="EnsemblGenomes-Tr:CAB12194" /db_xref="GOA:P94424" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:1ZCH" /db_xref="SubtiList:BG12040" /db_xref="UniProtKB/Swiss-Prot:P94424" /translation="MNEVIKSLTDHRSIRSYTDEPVAQEQLDQIIEAVQSAPSSINGQ QVTVITVQDKERKKKISELAGGQPWIDQAPVFLLFCADFNRAKIALEDLHDFKMEITN GLESVLVGAVDAGIALGTATAAAESLGLGTVPIGAVRGNPQELIELLELPKYVFPLSG LVIGHPADRSAKKPRLPQEAVNHQETYLNQDELTSHIQAYDEQMSEYMNKRTNGKETR NWSQSIASYYERLYYPHIREMLEKQGFKVEK*" gene complement(420484..421233) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" downshifts complement(420497) /Source="Nicolas_upshifts" /id="D171" /incds=0 /nref=136 /ntot=243 /MaxReadThrough="2.08639" /MaxDrop="5.10745" /score="11.1864402" /energy="-18.6" /TU="NA" /idTUdmin="U296" /TUdmin=0 /isTUend="TRUE" CDS complement(421250..421537) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17274596, 21454635; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AI-2 degrading enzyme" /protein_id="NP_388269.1" /db_xref="EnsemblGenomes-Gn:BSU03870" /db_xref="EnsemblGenomes-Tr:CAB12195" /db_xref="GOA:P94425" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12041" /db_xref="UniProtKB/Swiss-Prot:P94425" /translation="MIVLQAYIKVKPEKREEFLSEAQSLVQHSRAEEGNAQYDLFEKV GEENTFVMLEKWKDEAAMKFHNETAHFQGFVAKGKELLSAPLDVVRTELSE*" gene complement(421250..421537) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" promotor_-35 421503..421510 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421524..421543 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421543 /Source="Nicolas_upshifts" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(421581..421600) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421597) /Source="Nicolas_upshifts" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" promotor_-35 complement(421614..421621) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 421642..421649 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 421654 /Source="Nicolas_upshifts" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" promotor_-10 421660..421679 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 421677..421991 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388270.1" /db_xref="EnsemblGenomes-Gn:BSU03880" /db_xref="EnsemblGenomes-Tr:CAB12196" /db_xref="GOA:O31480" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12781" /db_xref="UniProtKB/Swiss-Prot:O31480" /translation="MNIPNHPETETLQLTKVLHALSDPLRLELVKQLAEAKEKTCSTC ADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAEDLEKAFPGLLEAVLNVDQD RW*" gene 421677..421991 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" downshifts 421983 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" CDS complement(421993..423432) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" gene complement(421993..423432) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" promotor_-10 complement(422317..422328) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(422323) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(422342..422348) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(423475..423494) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 423476..423483 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(423482) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 423497..423516 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 423501 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" promotor_-35 complement(423505..423512) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 423539..424849 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" gene 423539..424849 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" promotor_-35 424727..424733 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424747..424765 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424755 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" promotor_-35 424851..424858 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424873..424892 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424882 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" CDS 424918..426306 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" gene 424918..426306 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" downshifts 426314 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" promotor_-35 426364..426370 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 426384..426395 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 426385 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" CDS 426429..427292 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" gene 426429..427292 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" CDS 427312..428097 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" gene 427312..428097 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" misc_feature 427417..427436 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 427417 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 427505 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" downshifts 428099 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" CDS complement(428142..428756) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" gene complement(428142..428756) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" downshifts complement(428153) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" CDS complement(428769..430394) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" gene complement(428769..430394) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" CDS complement(430429..431001) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" gene complement(430429..431001) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" promotor_-10 complement(431023..431042) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(431038) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" promotor_-35 complement(431056..431063) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 431123..431142 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 431135 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" CDS 431166..431519 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" gene 431166..431519 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" downshifts 431490 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" promotor_-35 431583..431590 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431604..431623 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431609 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" S_feature 431619..431691 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 431692..433128 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" gene 431692..433128 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" CDS 433153..433584 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" gene 433153..433584 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" CDS 433586..434707 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" gene 433586..434707 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" downshifts 434690 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" promotor_-35 434736..434739 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 434755..434774 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 434757 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" CDS 434798..435862 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" gene 434798..435862 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" promotor_-35 435032..435040 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 435054..435073 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 435064 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 435856 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" promotor_-35 435929..435936 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 435949..435968 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 435962 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" CDS 435997..436560 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" gene 435997..436560 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" S_feature 436561..437285 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(436620..437228) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" gene complement(436620..437228) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" misc_feature complement(437246..437265) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 437262..437268 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(437269) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" promotor_-10 437281..437300 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 437287 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" CDS 437314..437706 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" gene 437314..437706 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" downshifts 437683 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" CDS complement(437739..437903) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" gene complement(437739..437903) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" downshifts complement(437759) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(437913..437931) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(437935) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" promotor_-35 complement(437946..437952) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 437965..437972 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 437986..438005 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 437989 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" CDS 438036..438785 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" gene 438036..438785 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" downshifts 438762 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" downshifts complement(438838) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" promotor_-35 438868..438874 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 438888..438907 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 438894..438990 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 438894 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" CDS 438991..439764 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" gene 438991..439764 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" CDS 439779..440993 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" gene 439779..440993 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" CDS 441017..441790 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" gene 441017..441790 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" CDS 441835..442557 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" gene 441835..442557 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" CDS 442560..443567 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" gene 442560..443567 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" downshifts 443053 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" promotor_no_box 443147..443247 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 443207 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" CDS 443583..444335 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" gene 443583..444335 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" promotor_-35 444333..444342 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 444356..444375 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 444366 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" CDS 444399..445040 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" gene 444399..445040 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" downshifts 445026 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" S_feature complement(445038..445463) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(445083) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" promotor_-35 445116..445122 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 445136..445155 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 445137 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" CDS 445213..445458 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" gene 445213..445458 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" S_feature 445459..445869 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(445464..445751) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" gene complement(445464..445751) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" misc_feature complement(445772..445791) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(445788) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" promotor_-35 445845..445849 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 445866..445885 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 445871 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" CDS 445902..447908 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" gene 445902..447908 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" S_feature 447909..448009 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 448010..448912 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" gene 448010..448912 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" downshifts 448892 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" promotor_-35 448985..448992 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 449006..449025 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 449010..449097 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 449010 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" CDS 449098..451182 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" gene 449098..451182 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" downshifts 451169 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" promotor_-35 451211..451217 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 451231..451249 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 451243 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" S_feature 451254..451335 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 451297..451304 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 451318..451337 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 451337 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" CDS 451394..452905 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" gene 451394..452905 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" downshifts 452889 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" CDS complement(452925..453470) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" gene complement(452925..453470) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" downshifts complement(452958) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(453537..453555) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(453551) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" promotor_-35 complement(453570..453576) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 453612..453618 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 453630 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" promotor_-10 453633..453651 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 453677..454537 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" gene 453677..454537 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" CDS 454553..455056 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" gene 454553..455056 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" downshifts 455037 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" promotor_-35 455085..455092 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455106..455125 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 455108 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" CDS 455142..455693 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" gene 455142..455693 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" promotor_-35 455708..455714 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455729..455747 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 455742 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" CDS 455771..456193 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" gene 455771..456193 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" promotor_-35 456198..456206 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 456217..456236 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 456236..456602 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 456236 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" promotor_no_box complement(456262..456362) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(456297..456565) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" gene complement(456297..456565) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" upshifts complement(456302) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 456559 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" promotor_-35 456639..456648 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 456661..456676 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 456666 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" CDS 456699..457508 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" gene 456699..457508 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" downshifts 457489 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" CDS complement(457552..457842) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" gene complement(457552..457842) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" downshifts complement(457556) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" misc_feature complement(457870..457889) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 457870..457888 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 457876 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(457886) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" promotor_-35 457964..457971 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 457985..458004 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 457989 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" CDS 458027..458461 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" gene 458027..458461 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" promotor_-35 458458..458461 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 458470 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" promotor_-10 458478..458497 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 458526..460709 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" gene 458526..460709 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" downshifts 460692 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" promotor_-35 460758..460764 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 460779..460797 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 460780..460911 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 460780 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" CDS 460912..462000 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" gene 460912..462000 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" CDS 461981..462832 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" gene 461981..462832 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" CDS 462843..464552 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" gene 462843..464552 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" CDS 464545..465807 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" gene 464545..465807 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" CDS 465813..467924 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" gene 465813..467924 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" downshifts 467908 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" promotor_-35 468021..468028 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 468043..468062 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 468050 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" misc_RNA 468060..468203 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" gene 468060..468203 /gene="swaO" /locus_tag="BSU_misc_RNA_7" downshifts 468201 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" S_feature 468246..468399 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 468400..470223 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" gene 468400..470223 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" downshifts 470215 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" CDS 470282..470731 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" gene 470282..470731 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" promotor_-35 470744..470750 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 470765..470783 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 470766 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" CDS 470798..472522 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" gene 470798..472522 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" S_feature complement(471634..472493) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(472495..472606) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 472506 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" CDS complement(472514..472717) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" gene complement(472514..472717) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" downshifts complement(472538) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" promotor_no_box complement(472566..472666) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 472575..472580 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 472597..472615 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472606) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" S_feature 472607..472822 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 472607 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" S_feature complement(472673..472744) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(472716) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" CDS complement(472745..473011) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" gene complement(472745..473011) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" promotor_-10 complement(473027..473046) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(473045) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" promotor_-35 complement(473058..473065) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(473115..474392) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" gene complement(473115..474392) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" downshifts complement(473134) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(474454..474473) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474466) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" S_feature complement(474468..474545) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(474486..474493) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(474529..474548) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474545) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" promotor_-35 complement(474562..474571) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(474622..474879) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" gene complement(474622..474879) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" downshifts complement(474630) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" downshifts complement(474696) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" CDS complement(474957..475409) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" gene complement(474957..475409) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" promotor_-10 complement(475428..475446) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(475445) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" promotor_-35 complement(475460..475466) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 475478 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" misc_feature 475486..475505 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 475527..476345 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" gene 475527..476345 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" downshifts 476336 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" promotor_-35 476413..476419 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476433..476451 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476441 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" CDS 476474..476845 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" gene 476474..476845 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" downshifts complement(476478) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" downshifts 476862 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" upshifts complement(476896) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(476899..476902) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 476924..476931 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476943..476962 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476950 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" CDS 476977..477318 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" gene 476977..477318 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" CDS 477312..477671 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" gene 477312..477671 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" S_feature complement(477374..477667) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 477612 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" downshifts 477656 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" CDS complement(477708..478529) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" gene complement(477708..478529) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" downshifts complement(477712) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" promotor_-10 complement(478551..478569) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478572) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" promotor_-35 complement(478583..478589) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(478614..479666) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" gene complement(478614..479666) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" promotor_-35 478926..478933 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 478948..479735 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 478948..478967 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478949 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" promotor_-10 complement(479679..479698) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(479684) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" promotor_-35 complement(479712..479719) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 479736..481343 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" gene 479736..481343 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" CDS 481333..482013 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" gene 481333..482013 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" S_feature 482014..482088 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 482055..482062 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 482077..482094 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 482090 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" CDS 482134..483399 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" gene 482134..483399 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" downshifts 483392 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" downshifts complement(483446) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" misc_feature 483483..483500 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 483485 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" CDS 483547..484599 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" gene 483547..484599 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" S_feature 484600..484843 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 484800 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" CDS 484876..485802 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" gene 484876..485802 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" CDS 485822..486562 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" gene 485822..486562 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" misc_feature 486621..486640 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 486626 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" CDS 486657..486992 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" gene 486657..486992 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" downshifts 486967 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" S_feature 487012..487081 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 487047..487054 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 487068..487087 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 487082 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" CDS 487120..488265 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" gene 487120..488265 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" downshifts 488247 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" CDS complement(488290..488469) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" gene complement(488290..488469) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" downshifts complement(488308) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" CDS complement(488423..488587) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" gene complement(488423..488587) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" S_feature complement(488470..488638) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(488630..488649) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(488640) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" promotor_-35 complement(488664..488671) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 488779..488784 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488800..488818 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488804 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" CDS 488834..489706 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" gene 488834..489706 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" promotor_-35 489070..489079 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 489092..489107 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 489095 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" S_feature complement(489651..489720) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(489694) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" S_feature 489707..490056 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(489721..490041) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" gene complement(489721..490041) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" promotor_-35 490037..490041 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 490050..490064 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 490058..490215 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 490058 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" promotor_-10 complement(490062..490081) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(490077) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" promotor_-35 complement(490095..490102) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 490216..491280 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" gene 490216..491280 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" downshifts 491268 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" CDS 491352..492725 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" gene 491352..492725 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" promotor_-35 492756..492762 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492776..492787 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 492786 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" misc_feature 492829..492848 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 492830..493004 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 492830 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" promotor_-35 492972..492979 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492994..493013 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 493006..493073 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 493006 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" CDS 493125..494609 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" gene 493125..494609 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" downshifts 494602 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" S_feature 494722..494781 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 494722..494731 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 494724 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" promotor_-10 494743..494758 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 494782..495261 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " gene 494782..495261 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" CDS 495251..496732 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" gene 495251..496732 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" downshifts 496702 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" S_feature 496747..497074 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(496756) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" CDS complement(496984..497583) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" gene complement(496984..497583) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" promotor_-35 497044..497049 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 497062..497081 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 497076..497677 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 497076 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" misc_feature complement(497607..497626) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(497618) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" CDS 497678..498043 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" gene 497678..498043 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" promotor_-35 498046..498051 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 498067..498208 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 498067..498085 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 498067 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" CDS 498209..499225 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" gene 498209..499225 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" downshifts 499210 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" promotor_-35 499270..499277 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 499291..499310 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 499298 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" CDS 499340..500509 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" gene 499340..500509 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" promotor_-35 500438..500443 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500458..500476 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500464 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" promotor_-35 500539..500542 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500558..500577 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500559 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" CDS 500625..500906 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" gene 500625..500906 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" CDS 500911..501261 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" gene 500911..501261 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" S_feature complement(501051..501527) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(501094) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" downshifts 501241 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" promotor_-35 501295..501302 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 501316..501335 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 501324 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" CDS 501376..502200 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" gene 501376..502200 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" promotor_-10 complement(501510..501528) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501527) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" S_feature complement(501529..502128) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(501542..501549) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(502117..502135) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(502128) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" S_feature complement(502130..502718) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(502149..502155) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 502205..502570 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" gene 502205..502570 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" CDS 502574..502975 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" gene 502574..502975 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" promotor_-10 complement(502716..502735) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(502733) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" promotor_-35 complement(502749..502758) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 502987..503994 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" gene 502987..503994 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" promotor_-35 503988..503994 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 504009..504027 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 504015 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" CDS 504056..504385 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" gene 504056..504385 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" CDS 504382..504864 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" gene 504382..504864 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" CDS 504830..505618 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" gene 504830..505618 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" CDS 505618..506217 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" gene 505618..506217 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" downshifts 506203 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" promotor_-35 506261..506267 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 506282..506301 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 506294 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 506328..506444 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" gene 506328..506444 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" CDS 506460..506753 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" gene 506460..506753 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" promotor_-35 506721..506729 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 506741..506760 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 506750..507190 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" gene 506750..507190 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" upshifts 506756 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" S_feature complement(506989..510044) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 507174..507617 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" gene 507174..507617 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" downshifts 507592 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" promotor_-35 507648..507649 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 507665..507684 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 507665 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" CDS 507711..509870 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" gene 507711..509870 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" misc_feature 509858..509877 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 509880..510096 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 509880 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" CDS complement(509880..509993) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" gene complement(509880..509993) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" promotor_-10 complement(510033..510052) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(510050) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" promotor_-35 complement(510067..510075) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 510097..510549 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" gene 510097..510549 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" promotor_-35 510555..510561 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 510576..510595 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 510584..510671 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 510584 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" downshifts complement(510616) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" tRNA 510672..510746 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 510672..510746 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" tRNA 510751..510841 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 510751..510841 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" tRNA 510871..510942 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 510871..510942 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" tRNA 510954..511028 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 510954..511028 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" tRNA 511055..511130 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 511055..511130 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" tRNA 511142..511223 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 511142..511223 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" downshifts 511288 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" tRNA 511304..511390 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 511304..511390 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" downshifts 511377 /Source="Nicolas_upshifts" /id="D229" /incds=0 /nref=82 /ntot=235 /MaxReadThrough="4.38481" /MaxDrop="5.23398" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=89 /isTUend="FALSE" S_feature 511422..512320 /Source="Nicolas_S_feature" /locus_tag="new_529454_530352" /HighExp="Cold, G180, G135, Paraq, Oxctl, C30, G150, H2O2, Fru, Lbexp" /AntisenseName="ydcL" /AntisenseCor="-0.23338643759911901" /AntisenseRegPval="-4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S169" downshifts complement(511445) /Source="Nicolas_upshifts" /id="D230" /incds=0 /nref=96 /ntot=231 /MaxReadThrough="2.93365" /MaxDrop="6.05127" /score="8.78044068" /energy="-9.2" /TU="U381" /idTUdmin="U381" /TUdmin="-125" /isTUend="FALSE" CDS complement(511473..512579) /gene="ydcL" /locus_tag="BSU_04800" /old_locus_tag="BSU04800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22505685; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: integrase" /protein_id="NP_388361.1" /db_xref="EnsemblGenomes-Gn:BSU04800" /db_xref="EnsemblGenomes-Tr:CAB12287" /db_xref="GOA:P96629" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG12099" /db_xref="UniProtKB/Swiss-Prot:P96629" /translation="MSVKKLENGQYQVDVSFGFDPITGERIRTRPVASTRKEALELEA KLRREFQEERARKSRSVSFPTLISIYLASCEIDSKPNYYQNQKYIINKHISDYFLKSD IQKITHREITDFRKHLMETGLSNKSVNNIMTSLSKIFDTAVHEEILKRNPCDNVKRLP LTRKKMKFWRPEEFKKFISLIPQDQLLFKTFYTVAFLTGLRCGEMLALQWKDIDKILL EIDVHKSCTWLDGQFVVTTPKTKNSIRRVSINKKLLKLLERWKEAQEELFNELGIRHS HDTYIFQYKDTPSRKDIFSRKIKYFCKDSDLTPIRLHDFRHSHVALLIHQGEDYITIK ERLGHGSVKTTIDVYGHLYPNKQKEMADKLDDLL*" gene complement(511473..512579) /gene="ydcL" /locus_tag="BSU_04800" /old_locus_tag="BSU04800" CDS complement(512592..513101) /gene="immA" /locus_tag="BSU_04810" /old_locus_tag="BSU04810" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:18761623, 21036995, 22505685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18761623, 21036995, 22505685; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: site-specific protease cleaving ImmR" /protein_id="NP_388362.1" /db_xref="EnsemblGenomes-Gn:BSU04810" /db_xref="EnsemblGenomes-Tr:CAB12288" /db_xref="GOA:P96630" /db_xref="InterPro:IPR010359" /db_xref="SubtiList:BG12100" /db_xref="UniProtKB/Swiss-Prot:P96630" /translation="MITIYTSKGIKHKVQSVIKTHGTNNVYEICDIQKIYILKNDLGQ ANGLLQHDKATDQYLIHINENLQHQQFVIAHELGHYFLHKRLNTFKVVNCSKVLKDKL EHQASLFASELILTDKMLNEALPYIQGFSKEQIAAYFNVPSFVTDYKLSQIGSFSNRI YSHEISAFG*" gene complement(512592..513101) /gene="immA" /locus_tag="BSU_04810" /old_locus_tag="BSU04810" downshifts complement(512904) /Source="Nicolas_upshifts" /id="D231" /incds=1 /nref=12 /ntot=39 /MaxReadThrough="6.14325" /MaxDrop="3.22989" /score="17.0287275" /energy="-11.8" /TU="U381" /idTUdmin="U384" /TUdmin=1518 /isTUend="FALSE" CDS complement(513098..513481) /gene="immR" /locus_tag="BSU_04820" /old_locus_tag="BSU04820" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8083175, 17511812, 22505685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8083175, 17511812, 22505685; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: transcriptional regulator(Xre family)" /protein_id="NP_388363.1" /db_xref="EnsemblGenomes-Gn:BSU04820" /db_xref="EnsemblGenomes-Tr:CAB12289" /db_xref="GOA:P96631" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG12101" /db_xref="UniProtKB/Swiss-Prot:P96631" /translation="MSLGKRLKEARQKAGYTQKEAAEKLNIGNNNLSNYERDYRDPDT DTLLKLSNLYNVSTDYLLGKDEVSKKNETDLLNKTINEAIQELKDEDTLLFMNDGEFD EETARLVKKALKNGIKFIDELKKKE*" gene complement(513098..513481) /gene="immR" /locus_tag="BSU_04820" /old_locus_tag="BSU04820" promotor_-10 complement(513510..513529) /Source="Nicolas_upshift_promotors" /id="U381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=3028 /SigmaFactorBS="tagaattatttatttaacttataggtgaaatTAATGAATtct ccaaaaaatgtTGTTATTATTTTTATAAAAAtcaactctttgtgaaatggatgataaa a" /listShort="immR, immA, ydcL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(513522) /Source="Nicolas_upshifts" /id="U381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=3028 /SigmaFactorBS="tagaattatttatttaacttataggtgaaatTAATGAATtct ccaaaaaatgtTGTTATTATTTTTATAAAAAtcaactctttgtgaaatggatgataaa a" /listShort="immR, immA, ydcL" /GFF_Attribute="listLong" promotor_-35 complement(513544..513551) /Source="Nicolas_upshift_promotors" /id="U381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=3028 /SigmaFactorBS="tagaattatttatttaacttataggtgaaatTAATGAATtct ccaaaaaatgtTGTTATTATTTTTATAAAAAtcaactctttgtgaaatggatgataaa a" /listShort="immR, immA, ydcL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 513681..513688 /Source="Nicolas_upshift_promotors" /id="U382" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2860 /SigmaFactorBS="tgttcaaaaaaatacactttaaggtgaattttgTGTTGACTt acacgaaaaggagTTTTATAATAAAGTTAATTCacaaagagttgagttaacgaggagg t" /listShort="sacV, ydzL, ydcO, S171, ydcP, ydcQ, ydcR" /listLong="S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /label="promotor_-35" promotor_-10 513703..513722 /Source="Nicolas_upshift_promotors" /id="U382" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2860 /SigmaFactorBS="tgttcaaaaaaatacactttaaggtgaattttgTGTTGACTt acacgaaaaggagTTTTATAATAAAGTTAATTCacaaagagttgagttaacgaggagg t" /listShort="sacV, ydzL, ydcO, S171, ydcP, ydcQ, ydcR" /listLong="S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /label="promotor_-10" upshifts 513708 /Source="Nicolas_upshifts" /id="U382" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2860 /SigmaFactorBS="tgttcaaaaaaatacactttaaggtgaattttgTGTTGACTt acacgaaaaggagTTTTATAATAAAGTTAATTCacaaagagttgagttaacgaggagg t" /listShort="sacV, ydzL, ydcO, S171, ydcP, ydcQ, ydcR" /listLong="S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" CDS 513755..513949 /gene="xis" /locus_tag="BSU_04830" /old_locus_tag="BSU04830" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3269394, 17511812, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3269394, 17511812, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: excisionase" /protein_id="NP_388364.1" /db_xref="EnsemblGenomes-Gn:BSU04830" /db_xref="EnsemblGenomes-Tr:CAB12290" /db_xref="GOA:O31490" /db_xref="SubtiList:BG12670" /db_xref="UniProtKB/Swiss-Prot:O31490" /translation="MKGEFLTARDIQKILGVKQAKSYDIIRTLNAQMKEEGYMVIQGK VSRAKFEECYCYKGPKSQTG*" gene 513755..513949 /gene="xis" /locus_tag="BSU_04830" /old_locus_tag="BSU04830" CDS 513946..514206 /gene="ydzL" /locus_tag="BSU_04839" /old_locus_tag="BSU04839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685, 26013486; Product type h:extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="YP_003097681.1" /db_xref="EnsemblGenomes-Gn:BSU04839" /db_xref="EnsemblGenomes-Tr:CAX52552" /db_xref="UniProtKB/Swiss-Prot:C0H3V5" /translation="MIFINIDITNSFMKEAVPLARQMEGDWIARMKIALNSVIINHYL NLPLTIENVNELLRKGVSYRRICKHYGIGRKDIEKLRQSSVV*" gene 513946..514206 /gene="ydzL" /locus_tag="BSU_04839" /old_locus_tag="BSU04839" CDS 514260..514520 /gene="ydcO" /locus_tag="BSU_04840" /old_locus_tag="BSU04840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685, 26013486; Product type h:extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388365.1" /db_xref="EnsemblGenomes-Gn:BSU04840" /db_xref="EnsemblGenomes-Tr:CAB12291" /db_xref="SubtiList:BG12102" /db_xref="UniProtKB/Swiss-Prot:P96632" /translation="MKIRVNATIITDVEALKADKDLNHFKDYATCETFVVDADNHLKA NEEISELLKGWDWWCIWSTRPLSKKDNQVFTLYNDDLYNLCR*" gene 514260..514520 /gene="ydcO" /locus_tag="BSU_04840" /old_locus_tag="BSU04840" S_feature complement(514380..514620) /Source="Nicolas_S_feature" /locus_tag="new_532412_532652_c" /HighExp="T5.0H, T4.0H, T3.0H, Lbstat, T3.30H, T2.0H, Cold, Gly, S2, T2.30H" /AntisenseName="ydcO" /AntisenseCor="0.131178357364787" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S170" promotor_-35 514546..514553 /Source="Nicolas_upshift_promotors" /id="U383" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.99000999000999" /xcortree=2861 /SigmaFactorBS="tgtcgataggagtgtttgttccttgaaaactacaTATAGACA aaaaaagcgccttgACGAATGATCATCAAGAACGccggaaaataaaaactagacactt t" /listShort="S171, ydcP, ydcQ, ydcR, S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(514551..514610) /gene="sncO" /locus_tag="BSU_misc_RNA_65" /product="ICEBs1 mobile element: conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796, 22505685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796, 22505685; Product type n: RNA" gene complement(514551..514610) /gene="sncO" /locus_tag="BSU_misc_RNA_65" promotor_-10 514568..514587 /Source="Nicolas_upshift_promotors" /id="U383" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.99000999000999" /xcortree=2861 /SigmaFactorBS="tgtcgataggagtgtttgttccttgaaaactacaTATAGACA aaaaaagcgccttgACGAATGATCATCAAGAACGccggaaaataaaaactagacactt t" /listShort="S171, ydcP, ydcQ, ydcR, S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 514572..514889 /Source="Nicolas_S_feature" /locus_tag="new_532604_532921" /HighExp="T0.30H, T0.0H, T1.0H, T1.30H, T-0.40H, T2.0H, HiOs, T2.30H, MG 120, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S171" upshifts 514572 /Source="Nicolas_upshifts" /id="U383" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.99000999000999" /xcortree=2861 /SigmaFactorBS="tgtcgataggagtgtttgttccttgaaaactacaTATAGACA aaaaaagcgccttgACGAATGATCATCAAGAACGccggaaaataaaaactagacactt t" /listShort="S171, ydcP, ydcQ, ydcR, S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /GFF_Attribute="listLong" promotor_-10 complement(514605..514624) /Source="Nicolas_upshift_promotors" /id="U384" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78021978021978" /psig="0.987012987012987" /xcortree=3113 /SigmaFactorBS="tttaaagtgattgctgttcatcactcaaatactcaCGCATGA CatttcaacaagaaTACCGTATAATAAAAGTGTCtagtttttattttccggcgttctt g" /listShort="S170" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(514620) /Source="Nicolas_upshifts" /id="U384" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78021978021978" /psig="0.987012987012987" /xcortree=3113 /SigmaFactorBS="tttaaagtgattgctgttcatcactcaaatactcaCGCATGA CatttcaacaagaaTACCGTATAATAAAAGTGTCtagtttttattttccggcgttctt g" /listShort="S170" /GFF_Attribute="listLong" promotor_-35 complement(514638..514645) /Source="Nicolas_upshift_promotors" /id="U384" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78021978021978" /psig="0.987012987012987" /xcortree=3113 /SigmaFactorBS="tttaaagtgattgctgttcatcactcaaatactcaCGCATGA CatttcaacaagaaTACCGTATAATAAAAGTGTCtagtttttattttccggcgttctt g" /listShort="S170" /GFF_Attribute="listLong" /label="promotor_-35" CDS 514726..514854 /locus_tag="BSU_04849" /old_locus_tag="BSU04849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 22505685" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: hypothetical protein" /protein_id="YP_009513947.1" /translation="MMAIISLLGCHEGVKPLATDKRQDGYRTGANQKHKIEINVLL*" gene 514726..514854 /locus_tag="BSU_04849" /old_locus_tag="BSU04849" CDS 514890..515270 /gene="helP" /locus_tag="BSU_04850" /old_locus_tag="BSU04850" /experiment="publication(s) with functional evidences, PMID:22505685, 23326247, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22505685, 23326247, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: helicase processivity factor" /protein_id="NP_388366.1" /db_xref="EnsemblGenomes-Gn:BSU04850" /db_xref="EnsemblGenomes-Tr:CAB12292" /db_xref="InterPro:IPR010365" /db_xref="SubtiList:BG12103" /db_xref="UniProtKB/Swiss-Prot:P96633" /translation="MNLNFIVPDINMTFGDMKFMGLNRERYVYDRENNKRTDVLESRI YNIASAVQGGQIEVTIPEYAGAKEIPPFADIELKNPKISAMATSQRDSTYANVMWKLE ADDIVVKGGSSVKPAAATGGNEKK*" gene 514890..515270 /gene="helP" /locus_tag="BSU_04850" /old_locus_tag="BSU04850" CDS 515306..516748 /gene="conQ" /locus_tag="BSU_04860" /old_locus_tag="BSU04860" /experiment="publication(s) with functional evidences, PMID:17511812, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17511812, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: coupling conjugation protein VirD4" /protein_id="NP_388367.1" /db_xref="EnsemblGenomes-Gn:BSU04860" /db_xref="EnsemblGenomes-Tr:CAB12293" /db_xref="GOA:P96634" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12104" /db_xref="UniProtKB/Swiss-Prot:P96634" /translation="MSDFLNKRFWKYRGKRIRPYMRNNVKLAGAIIFVPVFLLSMFLF WREQLIHFDLSQVIKNFEWNVPLIIKSVLCSVLIAVGSIVASYFLLFDSYKKILHRQK IAKMIFSNKFYEKENVKVRKIFSNETDSKEKITYFPRMYYQVKNNHIYIRIAMDMSRF QNRFLDLGKDLENGLFCDLVDKQMEEGFVCFKLLYDVKKNRISIDDAVAENGVLPLMK HISWQFDKLPHMLIAGGTGGGKTYFMLTIIKACVGLGADVRILDPKNADLADLEEVLP KKVYSQKNGILMCLRKSVDGMMERMDEMKQMSNYKTGENYAYLGLKPVFIFFDEYVAF MDLLDMKERNEALSYMKQLVMLGRQAGYFLVLGAQRPDAKYLADGIRDQFSFRVSLGL MSDTGYGMMFGDVEKAYVNKKETGRGYANVGTGSVLEFYSPIVPKGYDFMSSIKNALV GVEGAQATAVASGSVSDQTASGEGVSEANG*" gene 515306..516748 /gene="conQ" /locus_tag="BSU_04860" /old_locus_tag="BSU04860" CDS 516741..517799 /gene="nicK" /locus_tag="BSU_04870" /old_locus_tag="BSU04870" /experiment="publication(s) with functional evidences, PMID:17511812, 17693500, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17511812, 17693500, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: DNA relaxase" /protein_id="NP_388368.1" /db_xref="EnsemblGenomes-Gn:BSU04870" /db_xref="EnsemblGenomes-Tr:CAB12294" /db_xref="GOA:P96635" /db_xref="InterPro:IPR003491" /db_xref="SubtiList:BG12105" /db_xref="UniProtKB/Swiss-Prot:P96635" /translation="MDELKQPPHANRGVVIVKEKNEAVESPLVSMVDYIRVSFKTHDV DRIIEEVLHLSKDFMTEKQSGFYGYVGTYELDYIKVFYSAPDDNRGVLIEMSGQGCRQ FESFLECRKKTWYDFFQDCMQQGGSFTRFDLAIDDKKTYFSIPELLKKAQKGECISRF RKSDFNGSFDLSDGITGGTTIYFGSKKSEAYLCFYEKNYEQAEKYNIPLEELGDWNRY ELRLKNERAQVAIDALLKTKDLTLIAMQIINNYVRFVDADENITREHWKTSLFWSDFI GDVGRLPLYVKPQKDFYQKSRNWLRNSCAPTMKMVLEADEHLGKTDLSDMIAEAELAD KHKKMLDVYMADVADMVV*" gene 516741..517799 /gene="nicK" /locus_tag="BSU_04870" /old_locus_tag="BSU04870" downshifts 516744 /Source="Nicolas_upshifts" /id="D232" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="5.48512" /MaxDrop="3.25403" /score="-9.5933493" /energy="-23.1" /TU="U382,U383" /idTUdmin="U382" /TUdmin="-176" /isTUend="FALSE" S_feature 517800..518063 /Source="Nicolas_S_feature" /locus_tag="new_535832_536095" /HighExp="T0.30H, T1.0H, T1.30H, T0.0H, T2.0H, T2.30H, T-0.40H, T3.0H, T3.30H, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigA" /TUlongPSig=1 /label="S172" CDS 518064..518333 /gene="ydcS" /locus_tag="BSU_04880" /old_locus_tag="BSU04880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388369.1" /db_xref="EnsemblGenomes-Gn:BSU04880" /db_xref="EnsemblGenomes-Tr:CAB12295" /db_xref="SubtiList:BG12106" /db_xref="UniProtKB/Swiss-Prot:P96636" /translation="MHNVNLLNQAGLENALESVGCLDIVEDLIEKMQEYVLYHTETAE RFAIDIFTVVNNYTKKVHAIFNVLENEDGETNVKNVEFEVMHFTE*" gene 518064..518333 /gene="ydcS" /locus_tag="BSU_04880" /old_locus_tag="BSU04880" promotor_-10 complement(518124..518143) /Source="Nicolas_upshift_promotors" /id="U385" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.956043956043956" /psig="0.998001998001998" /xcortree=2065 /SigmaFactorBS="aatctttcggcagtttcggtatgatacaaaacataTTCCTGC AtcttttctattaaaTCTTCTACAATATCTAAACAgccaactgattccaaagcatttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(518140) /Source="Nicolas_upshifts" /id="U385" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.956043956043956" /psig="0.998001998001998" /xcortree=2065 /SigmaFactorBS="aatctttcggcagtttcggtatgatacaaaacataTTCCTGC AtcttttctattaaaTCTTCTACAATATCTAAACAgccaactgattccaaagcatttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(518158..518165) /Source="Nicolas_upshift_promotors" /id="U385" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.956043956043956" /psig="0.998001998001998" /xcortree=2065 /SigmaFactorBS="aatctttcggcagtttcggtatgatacaaaacataTTCCTGC AtcttttctattaaaTCTTCTACAATATCTAAACAgccaactgattccaaagcatttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 518372..518638 /gene="ydcT" /locus_tag="BSU_04890" /old_locus_tag="BSU04890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388370.1" /db_xref="EnsemblGenomes-Gn:BSU04890" /db_xref="EnsemblGenomes-Tr:CAB12296" /db_xref="SubtiList:BG12107" /db_xref="UniProtKB/Swiss-Prot:P96637" /translation="MFNINLLNQARLESDLDSLGCLDIAEELIEKMMEDVFYSDVAQR IIVQTLAVINNANAKLQATFNILEDEDMETDERSVEFEGISYYE*" gene 518372..518638 /gene="ydcT" /locus_tag="BSU_04890" /old_locus_tag="BSU04890" CDS 518655..518963 /gene="yddA" /locus_tag="BSU_04900" /old_locus_tag="BSU04900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388371.1" /db_xref="EnsemblGenomes-Gn:BSU04900" /db_xref="EnsemblGenomes-Tr:CAB12297" /db_xref="SubtiList:BG12108" /db_xref="UniProtKB/Swiss-Prot:P96638" /translation="MSAVDKRFKSLGFNVGIPSLVFVRSLSRDCMLVVEGERVKGFAE YRYTFYKTRYLPDGRMTSLKVYMENQSIKRVLHRVASFLSFLERTKQIEQKECEKVAQ *" gene 518655..518963 /gene="yddA" /locus_tag="BSU_04900" /old_locus_tag="BSU04900" CDS 518953..520017 /gene="conB" /locus_tag="BSU_04910" /old_locus_tag="BSU04910" /experiment="publication(s) with functional evidences, PMID:22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: subunit of the conjugation machinery VirB8" /protein_id="NP_388372.1" /db_xref="EnsemblGenomes-Gn:BSU04910" /db_xref="EnsemblGenomes-Tr:CAB12298" /db_xref="GOA:O31491" /db_xref="InterPro:IPR024735" /db_xref="InterPro:IPR035628" /db_xref="SubtiList:BG12109" /db_xref="UniProtKB/Swiss-Prot:O31491" /translation="MLNKEIGSDKKEESFFRSAFQKLKRIERPEKDKQKVPRDRSKLI AVTLWSCVGSLLFICLLAVLLSINTRSQLNDMKDETNKPTNDDKQKISVTAAENFLSG FINEYMNVKNDQESIEKRMQSLESYMVKQEDNHFEDEERFNVDGLKGDRELKGYSLYN VKEGDKNSLFQYKVTYENLYPVEKEVEKEVKDGKKKKKVKEKVKTNEKYEKQMLLNIP VTNKGDSFAVSAVPYFTQIYDLKGDIAFKGKEETRDEYAGEKKESIESFLQNFFEKYA SEKKEEMVYMMKKPEALEGNLLFGEVQSVKIFETKKGFEVFCAVRFKEKENDIPVNEK FSLEITENSGQFYVNKLKHQ*" gene 518953..520017 /gene="conB" /locus_tag="BSU_04910" /old_locus_tag="BSU04910" misc_feature 519491..519498 /Source="Nicolas_upshift_promotors" /id="U386" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.454545454545455" /xcortree=1489 /SigmaFactorBS="tgaaagaaggtgataaaaacagcctttttcaatataaggtca catatgaaaatctatACCCTGTAgaaaaggaagttgaaaaagaagttaaagacggaaa g" /listShort="yddC, yddD, yddE, yddF, yddG, yddH, yddI" /listLong="yddJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 519494 /Source="Nicolas_upshifts" /id="U386" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.454545454545455" /xcortree=1489 /SigmaFactorBS="tgaaagaaggtgataaaaacagcctttttcaatataaggtca catatgaaaatctatACCCTGTAgaaaaggaagttgaaaaagaagttaaagacggaaa g" /listShort="yddC, yddD, yddE, yddF, yddG, yddH, yddI" /listLong="yddJ" downshifts 519582 /Source="Nicolas_upshifts" /id="D233" /incds=1 /nref=1 /ntot=15 /MaxReadThrough="6.32422" /MaxDrop="3.45679" /score="-2.67923628" /energy="-7.8" /TU="U383,U386" /idTUdmin="U382" /TUdmin=2662 /isTUend="FALSE" CDS 520029..520277 /gene="conC" /locus_tag="BSU_04920" /old_locus_tag="BSU04920" /function="18: Unknown function" /experiment="publication(s) with functional evidences, PMID:22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: subunit of the conjugation machinery" /protein_id="NP_388373.1" /db_xref="EnsemblGenomes-Gn:BSU04920" /db_xref="EnsemblGenomes-Tr:CAB12299" /db_xref="GOA:P96640" /db_xref="SubtiList:BG12110" /db_xref="UniProtKB/Swiss-Prot:P96640" /translation="MDFMNFFILGADLPTLGGVKGWASDVVIQFITIVVMFIAAKNLM KLKMGGIIFVCCIGSAVTWVIKHWSEFSGWINALMEKL*" gene 520029..520277 /gene="conC" /locus_tag="BSU_04920" /old_locus_tag="BSU04920" CDS 520290..520814 /gene="conD" /locus_tag="BSU_04930" /old_locus_tag="BSU04930" /experiment="publication(s) with functional evidences, PMID:22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: subunit of the conjugation machinery" /protein_id="NP_388374.1" /db_xref="EnsemblGenomes-Gn:BSU04930" /db_xref="EnsemblGenomes-Tr:CAB12300" /db_xref="GOA:P96641" /db_xref="InterPro:IPR025608" /db_xref="SubtiList:BG12111" /db_xref="UniProtKB/Swiss-Prot:P96641" /translation="MGRLVFNYRKAMREPKKIQQLTENYSLPFAVELIPAINYFIFVG LCFGFWYGVRMIFPHAFDNSYVIVIFGIPFFLTMLVTKIKPEGKNIYIYFFDFAKYYF FIKLPQKKYCNDRKIDLSNEKQIEFRKLVKVVDYSNETKNAYEGNTQEFAVNKNGRRV GVLPNKKQFDSYAK*" gene 520290..520814 /gene="conD" /locus_tag="BSU_04930" /old_locus_tag="BSU04930" CDS 520702..523197 /gene="conE" /locus_tag="BSU_04940" /old_locus_tag="BSU04940" /experiment="publication(s) with functional evidences, PMID:19734305, 19943900, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19734305, 19943900, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: VirB4-like ATPase" /protein_id="NP_388375.3" /db_xref="EnsemblGenomes-Gn:BSU04940" /db_xref="EnsemblGenomes-Tr:CAB12301" /db_xref="GOA:P96642" /db_xref="InterPro:IPR016628" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12112" /db_xref="UniProtKB/Swiss-Prot:P96642" /translation="MRLKTPMKAIHKNLLLTRTGDVWAYYRIKSNSIPMQNKEKVESY KKKWQHLFEEITSYEDFHLMMYPSEYELEKRFKDLETDIAADAMDVARYYNEETVRLL EQRLGRLTKYDFILGVKLKSSLVNISVELKDNILSFFNTATDTVVKMLGWEQNVSTSF FEKYEEVEETLANIMASVRGERLSETEMTYINRYHFVRGLKHQTNEESEIKDVRSITN TIIDPTDPSVLHLHSDQDEGYSAFVVIDEFLHNMSESDLFYEAQSLPFPVEVQMKIQT ESKSITKPALNLKRQQLKEEQKEQQSTGDRSDVSTVTSATMIRHLQDEIKKEDVHVMN WLSVIVVHGKTKKECVGKATIVKRHLKGAGITCRLPVADQLNLFYKMLPGEKLDITDK NWIQKTTQDGVAESLFAVNSDIGSKIGFFLGWVDRFQEHTDLESAIMSSRDFVLFHPF LANQQLKGSKTRSPHCLITGDTGNGKSYLAKLIFNYISMLNIKSLYIDPKKEMRKWIQ RVLNDEYIRENFPLYIAHLEKYNYITLDHENTHNWGALDPISFLPPMKAKELVQVIFE QVYDFKGKDDINTAFLRATSEVIDAKQKGEQVGSLDIIRKMQSHPEEAVQKAGDYLNE VVSDSILKLCIHDGSNPALSLEKRITILEVENMDLPDHAERLENYTISQLKSSAVMFA LGKFCELFGMNQDEQTVEFIDEAWIFTTSQQGKKVERQMRRIGRSYNNAEYFISQSTK DALKEEDSGNFGVAFAFDEPNEREEVLKWMNMEVTKDNKKMMESMFQGQCLFKDYYGR TSKISIECLFEEWQGALKTVEKKAVAYAEEKYL*" gene 520702..523197 /gene="conE" /locus_tag="BSU_04940" /old_locus_tag="BSU04940" CDS 523216..523542 /gene="yddF" /locus_tag="BSU_04950" /old_locus_tag="BSU04950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19943900, 22505685, 26013486; Producttype h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388376.1" /db_xref="EnsemblGenomes-Gn:BSU04950" /db_xref="EnsemblGenomes-Tr:CAB12302" /db_xref="InterPro:IPR015055" /db_xref="SubtiList:BG12113" /db_xref="UniProtKB/Swiss-Prot:P96643" /translation="MEIAFLNSLVVTSPGFYKAEKITLDEVKQWLKHYDGRYKSFIGH KSTAQFLQKLLGIRIEQNRKTFRHMKYQKAICFSLYERYPENVLLTQRDLEKARYQFY LLTRLD*" gene 523216..523542 /gene="yddF" /locus_tag="BSU_04950" /old_locus_tag="BSU04950" CDS 523546..525993 /gene="conG" /locus_tag="BSU_04960" /old_locus_tag="BSU04960" /experiment="publication(s) with functional evidences, PMID:19943900, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19943900, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: VirB6 subunit of the conjugation machinery" /protein_id="NP_388377.1" /db_xref="EnsemblGenomes-Gn:BSU04960" /db_xref="EnsemblGenomes-Tr:CAB12303" /db_xref="GOA:P96644" /db_xref="InterPro:IPR000515" /db_xref="SubtiList:BG12114" /db_xref="UniProtKB/Swiss-Prot:P96644" /translation="MVVMKKKRILIVSAIVLLFLTVASAVTVFSADGDTTTQPKVEKA GGVELKVKRFPISRYQANNEASDDLIKGAFVGLTNVTFSFAGNIVRVVDTGMDILYNL QPIDEFANSITNVSKTVYKTLKKNFGEALFIFTCAYVVYLFCVRGSVKEAMRRSILFI CVMVIGGLWMSNAGYYMKVLNALSVEAQGKLLTAGNGLVGIVQDEGNFADSSAIEKGK EMEGTVAVMRNLYFDIALMKPFLIVNFDETSEKKINEEDTDKGGLNRIDKLLSYKLSE DGEKDKKDYIKETEIDDYKNESMTSGNVFNQLGESFIAVVASIVIGIPFLALAFFNFL LQVVALVIVFFVPFAFILAYVPQLAYSGFVTLGRLGSVYLLKAMLGVIVLFVYVTCFI VDKLIPPNGFGMYLLNVAVLASILWIGFHKRDAIIKFVTAGKVVSVDNNMMENMRQNI VQPAWEQAKKIGGVWGNGGGVFTDFTKHFGGRKDGSNADGVTGAPSGGGNSPSGTAMG YDNTHAISRTPQKETANGIANHNSRSLKRNPQTLSKEQEKQKQKEAFANAKENKQQSH LARLRKDGINSPMLKDALNEGNEDLSKRAPILQDKKDESARTDQKEYVEQLLKQPNNQ QQTDDASLQHEEESTSNRAPVLQENEKDTERTDQKAYIYDEQNQNLETDQQQDFEVQK DDSVSNSEPVAQEKTAEIKRSDQKVMMNQPEPQLGFESPQSTKVENQPIANNERKIRP SEPAKVHSDGIRVDEKQAVAPAENKTVSREKQPSSQTIKRTEQSVNSFDQVSLNEIAR RSSSKVEDRLRRDERTR*" gene 523546..525993 /gene="conG" /locus_tag="BSU_04960" /old_locus_tag="BSU04960" CDS 525990..526979 /gene="cwlT" /locus_tag="BSU_04970" /old_locus_tag="BSU04970" /experiment="publication(s) with functional evidences, PMID:18305117, 22505685, 24532767, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18305117, 22505685, 24532767, 26013486; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: two-domain autolysin withN-acetylmuramidase and DL-endopeptidase activity VirB1" /protein_id="NP_388378.1" /db_xref="EnsemblGenomes-Gn:BSU04970" /db_xref="EnsemblGenomes-Tr:CAB12304" /db_xref="GOA:P96645" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG12115" /db_xref="UniProtKB/Swiss-Prot:P96645" /translation="MISKKVVLPLVFSAPFIFFFVLCIVVVMTISRENQVGDDFIGGG DGEYETVGIAPEVERFRAVFEKYARQEGVFDQVNIIMALTMQESGGRSLDIMQSSESI GLPPNSITDPERSIEVGIKHFKKVFKQAGGDVRLTLQAYNFGSGFIDYVKKNGGKYTK KLALDFSRLQAFKMGWKSYGDPSYVDHVMRYVKGSDKNVKPVKGSMDFYETVMKEALK YEGQPYAWGGSNPETGFDCSGLVQWSFAKAGITLPRTAQEQHGATKKISEKEATAGDL VFFGGTYEGKAITHVGIYVGNGRMFNSNDSGIQYSDLKSGYWRDHLVSFGRIK*" gene 525990..526979 /gene="cwlT" /locus_tag="BSU_04970" /old_locus_tag="BSU04970" CDS 526994..527500 /gene="yddI" /locus_tag="BSU_04980" /old_locus_tag="BSU04980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388379.1" /db_xref="EnsemblGenomes-Gn:BSU04980" /db_xref="EnsemblGenomes-Tr:CAB12305" /db_xref="GOA:P96646" /db_xref="SubtiList:BG12116" /db_xref="UniProtKB/Swiss-Prot:P96646" /translation="MKTHIAWASACLLLVMLTGFFTIGQQTYKIEKLKDKNEVLSEKI KELNHIESTSSASENKAFFEAFFNYSDIDIRYETVKKHTTGKGFDYAFPSRSDQKHTV SVQSELLSLESYSKPLDESHELFLNIVEVATTANSVTTNQVLIVQTTMKKEKDGWLVD NVQVKGNG*" gene 526994..527500 /gene="yddI" /locus_tag="BSU_04980" /old_locus_tag="BSU04980" promotor_-35 527503..527509 /Source="Nicolas_upshift_promotors" /id="U387" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.464535464535465" /psig="0.997002997002997" /xcortree=555 /SigmaFactorBS="ataatgtgcaggttaagggaaatggataaaaGGTGGAAaaga tcaatttgtTTGTTTATACTAAATATTGAaaaaggaggtaatgtttattttgaaaaac c" /listShort="yddJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 527523..527542 /Source="Nicolas_upshift_promotors" /id="U387" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.464535464535465" /psig="0.997002997002997" /xcortree=555 /SigmaFactorBS="ataatgtgcaggttaagggaaatggataaaaGGTGGAAaaga tcaatttgtTTGTTTATACTAAATATTGAaaaaggaggtaatgtttattttgaaaaac c" /listShort="yddJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 527532 /Source="Nicolas_upshifts" /id="U387" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.464535464535465" /psig="0.997002997002997" /xcortree=555 /SigmaFactorBS="ataatgtgcaggttaagggaaatggataaaaGGTGGAAaaga tcaatttgtTTGTTTATACTAAATATTGAaaaaggaggtaatgtttattttgaaaaac c" /listShort="yddJ" /GFF_Attribute="listLong" CDS 527563..527943 /gene="yddJ" /locus_tag="BSU_04990" /old_locus_tag="BSU04990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: putative lipoprotein of unknown function" /protein_id="NP_388380.1" /db_xref="EnsemblGenomes-Gn:BSU04990" /db_xref="EnsemblGenomes-Tr:CAB12306" /db_xref="InterPro:IPR028075" /db_xref="SubtiList:BG12117" /db_xref="UniProtKB/Swiss-Prot:P96647" /translation="MKNLFIFLSLMMMFVLTACGGSKYDDAIDDVISQYKEHKGNDTE INIKRENAIVRVYEGGKYIQFAFYMPDNSSRELTTFKYYEKFGDKYEKMTDMPGNGEN DRLGLSKKTPDYEEVKGEETELEE*" gene 527563..527943 /gene="yddJ" /locus_tag="BSU_04990" /old_locus_tag="BSU04990" downshifts 527920 /Source="Nicolas_upshifts" /id="D234" /incds=0 /nref=167 /ntot=245 /MaxReadThrough="2.07932" /MaxDrop="5.51482" /score="8.08816145" /energy="-14.7" /TU="NA" /idTUdmin="U383" /TUdmin=0 /isTUend="TRUE" downshifts complement(527996) /Source="Nicolas_upshifts" /id="D235" /incds=0 /nref=51 /ntot=228 /MaxReadThrough="3.21157" /MaxDrop="4.80215" /score="-2.66780619" /energy="-18.7" /TU="U388" /idTUdmin="U388" /TUdmin="-110" /isTUend="FALSE" S_feature complement(528019..528133) /Source="Nicolas_S_feature" /locus_tag="new_546051_546165_c" /HighExp="LPhT, Lbtran, Mt0, HiTm, Lbexp, M40t45, M0t45, HPh, dia0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S173" downshifts complement(528062) /Source="Nicolas_upshifts" /id="D236" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="5.69722" /MaxDrop="4.64006" /score="-2.66780619" /energy="-18.7" /TU="U388" /idTUdmin="U388" /TUdmin="-176" /isTUend="FALSE" CDS complement(528134..528934) /gene="yddK" /locus_tag="BSU_05000" /old_locus_tag="BSU05000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388381.1" /db_xref="EnsemblGenomes-Gn:BSU05000" /db_xref="EnsemblGenomes-Tr:CAB12307" /db_xref="GOA:P96648" /db_xref="InterPro:IPR000157" /db_xref="InterPro:IPR035897" /db_xref="SubtiList:BG12118" /db_xref="UniProtKB/Swiss-Prot:P96648" /translation="MDTLKKLKFEANGIIGVLLDYSREPVLTNIIDQFRTSLESNDIE LIRYSLEQLKTWYARNRNEIYKNEFVFNEFEHHETENKIKKFLDELPVVDETEKSSIT HFSSDQNRELEKKIFISHSSKDKIVCNAFVELLEDIGVSSEDIIYTSSPYHGIPGDED IFEYLKKHLFKGAYVFYMLSDNYYDSVYCLNEMGATWVNSNNCSTFILPGFKGEIKGV IDKNKKAFSLEEPIDLFNLKEKILRMYDLTLEDKKWERIKAKFNTKLK*" gene complement(528134..528934) /gene="yddK" /locus_tag="BSU_05000" /old_locus_tag="BSU05000" promotor_-10 complement(528979..528998) /Source="Nicolas_upshift_promotors" /id="U388" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2317 /SigmaFactorBS="tttatgaattacccaaacaatccagactgctttaaaataaGT AGttagaataggagtctATGTTATATAATTAGATATGaaatgtttacaaacaatggat t" /listShort="yddK, S173" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(528997) /Source="Nicolas_upshifts" /id="U388" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2317 /SigmaFactorBS="tttatgaattacccaaacaatccagactgctttaaaataaGT AGttagaataggagtctATGTTATATAATTAGATATGaaatgtttacaaacaatggat t" /listShort="yddK, S173" /GFF_Attribute="listLong" promotor_-35 complement(529014..529017) /Source="Nicolas_upshift_promotors" /id="U388" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2317 /SigmaFactorBS="tttatgaattacccaaacaatccagactgctttaaaataaGT AGttagaataggagtctATGTTATATAATTAGATATGaaatgtttacaaacaatggat t" /listShort="yddK, S173" /GFF_Attribute="listLong" /label="promotor_-35" CDS 529274..530449 /gene="rapI" /locus_tag="BSU_05010" /old_locus_tag="BSU05010" /EC_number="3.1.-.-" /experiment="publication(s) with functional evidences, PMID:16105942, 22505685, 23526881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16105942, 22505685, 23526881; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: response regulator aspartate phosphatase" /protein_id="NP_388382.1" /db_xref="EnsemblGenomes-Gn:BSU05010" /db_xref="EnsemblGenomes-Tr:CAB12308" /db_xref="GOA:P96649" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4I1A" /db_xref="SubtiList:BG12119" /db_xref="UniProtKB/Swiss-Prot:P96649" /translation="MRGVFLDKDKIPYDLVTKKLNEWYTSIKNDQVEQAEIIKTEVEK ELLNMEENQDALLYYQLLEFRHEIMLSYMKSKEIEDLNNAYETIKEIEKQGQLTGMLE YYFYFFKGMYEFRRKELISAISAYRIAESKLSEVEDEIEKAEFFFKVSYVYYYMKQTY FSMNYANRALKIFREYEEYAVQTVRCQFIVAGNLIDSLEYERALEQFLKSLEISKESN IEHLIAMSHMNIGICYDELKEYKKASQHLILALEIFEKSKHSFLTKTLFTLTYVEAKQ QNYNVALIYFRKGRFIADKSDDKEYSAKFKILEGLFFSDGETQLIKNAFSYLASRKMF ADVENFSIEVADYFHEQGNLMLSNEYYRMSIEARRKIKKGEIIDENQPDSIGSSDFK* " gene 529274..530449 /gene="rapI" /locus_tag="BSU_05010" /old_locus_tag="BSU05010" promotor_-35 530129..530136 /Source="Nicolas_upshift_promotors" /id="U389" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=2790 /SigmaFactorBS="aacaaaattataatgttgctttgatatacTTTAGGAAagggc gatttattGCCGATAAAAGTGATGATAaggaatactcagcgaaattcaaaatattaga g" /listShort="phrI, yddM, S174" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 530150..530168 /Source="Nicolas_upshift_promotors" /id="U389" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=2790 /SigmaFactorBS="aacaaaattataatgttgctttgatatacTTTAGGAAagggc gatttattGCCGATAAAAGTGATGATAaggaatactcagcgaaattcaaaatattaga g" /listShort="phrI, yddM, S174" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 530160 /Source="Nicolas_upshifts" /id="U389" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=2790 /SigmaFactorBS="aacaaaattataatgttgctttgatatacTTTAGGAAagggc gatttattGCCGATAAAAGTGATGATAaggaatactcagcgaaattcaaaatattaga g" /listShort="phrI, yddM, S174" /GFF_Attribute="listLong" promotor_-35 530357..530363 /Source="Nicolas_upshift_promotors" /id="U390" /multdbtbs="SigH" /comp="M8" /sig="SigGF" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=882 /SigmaFactorBS="agtcgctgattattttcatgaacaaggaaatttaatgctctc taatgaatattatCGTATGAgtattgaagcaagaCGAAAAATTAAAaaaggggagatt a" /listShort="phrI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 530362 /Source="Nicolas_upshifts" /id="U390" /multdbtbs="SigH" /comp="M8" /sig="SigGF" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=882 /SigmaFactorBS="agtcgctgattattttcatgaacaaggaaatttaatgctctc taatgaatattatCGTATGAgtattgaagcaagaCGAAAAATTAAAaaaggggagatt a" /listShort="phrI" /GFF_Attribute="listLong" promotor_-10 530378..530389 /Source="Nicolas_upshift_promotors" /id="U390" /multdbtbs="SigH" /comp="M8" /sig="SigGF" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=882 /SigmaFactorBS="agtcgctgattattttcatgaacaaggaaatttaatgctctc taatgaatattatCGTATGAgtattgaagcaagaCGAAAAATTAAAaaaggggagatt a" /listShort="phrI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 530406..530525 /gene="phrI" /locus_tag="BSU_05020" /old_locus_tag="BSU05020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200, 21908671, 22505685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200, 21908671, 22505685; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: secreted regulator of theactivity of phosphatase RapI" /protein_id="NP_388383.1" /db_xref="EnsemblGenomes-Gn:BSU05020" /db_xref="EnsemblGenomes-Tr:CAB12309" /db_xref="SubtiList:BG12645" /db_xref="UniProtKB/Swiss-Prot:O31492" /translation="MKISRILLAAVILSSVFSITYLQSDHNTEIKVAADRVGA*" gene 530406..530525 /gene="phrI" /locus_tag="BSU_05020" /old_locus_tag="BSU05020" downshifts 530523 /Source="Nicolas_upshifts" /id="D237" /incds=0 /nref=46 /ntot=227 /MaxReadThrough="4.14733" /MaxDrop="5.8523" /score="15.7846721" /energy="-10.4" /TU="U389" /idTUdmin="U390" /TUdmin="-15" /isTUend="TRUE" CDS 530678..531619 /gene="yddM" /locus_tag="BSU_05030" /old_locus_tag="BSU05030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22505685; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: putative helicase" /protein_id="NP_388384.1" /db_xref="EnsemblGenomes-Gn:BSU05030" /db_xref="EnsemblGenomes-Tr:CAB12310" /db_xref="GOA:P96650" /db_xref="SubtiList:BG12120" /db_xref="UniProtKB/Swiss-Prot:P96650" /translation="MGENMFKKEKVTEYIWTILIPTIITFIISWVGSYYNGTSTVSIG QPTKVSGQYITPINISPYHDIKELRITFPQKLDVKQISSNEPINVKSDKNNIGVESNS TFEIAKIVENNSVQLLITTQKKLNDKEIRIDKNGNNISVNYESQIVNPAKKQLINLII TSSIYFIMLNILALIMNKRWDKYYAKMKNEIKEFEDNAKDLDKKSKKKSEELSELRKT LNQAFEETDRIKYHEKKKQILLLAKLNDYKKELTFWRNTIRKVLYELPDGDKKADKLI GTVTSSLKTYGTVEKNEHDYESLKVAAALLNDSDKRS*" gene 530678..531619 /gene="yddM" /locus_tag="BSU_05030" /old_locus_tag="BSU05030" S_feature 531620..531878 /Source="Nicolas_S_feature" /locus_tag="new_549652_549910" /HighExp="HPh, S1, Gly, LoTm, LPh, MG 120, GM-0.1, aero, S2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80510899999999996" /TUshortSig="SigD" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S174" S_feature complement(531891..532207) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S175" downshifts 531920 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" downshifts complement(531952) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" CDS complement(532208..533227) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" gene complement(532208..533227) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" promotor_-10 complement(532903..532922) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(532916) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" promotor_-35 complement(532937..532944) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 533016..533020 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 533037..533056 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 533041 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" S_feature 533042..533486 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 533487..533897 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" gene 533487..533897 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" S_feature 533898..533967 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 533924 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" CDS complement(534020..534469) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" gene complement(534020..534469) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" CDS 534584..535126 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" gene 534584..535126 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" promotor_-35 535599..535603 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 535620..535639 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 535629 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" CDS 535679..536443 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" gene 535679..536443 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" CDS 536637..537947 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" gene 536637..537947 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" S_feature 537970..538529 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 538530..538706 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" gene 538530..538706 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" CDS 538731..539417 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" gene 538731..539417 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" promotor_-35 539759..539763 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 539778..539797 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 539786 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" CDS 539841..540026 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" gene 539841..540026 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" downshifts 540025 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" CDS 540376..540969 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" gene 540376..540969 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" promotor_-35 541082..541089 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 541103..541122 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 541114..541231 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 541114 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" downshifts complement(541149) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" CDS 541232..541432 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" gene 541232..541432 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" S_feature complement(541330..542118) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 541335 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" downshifts 541436 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" misc_RNA complement(541500..541578) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" gene complement(541500..541578) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" CDS complement(542119..542580) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" gene complement(542119..542580) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" S_feature 542589..543134 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(542632) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" promotor_-10 complement(542639..542658) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(542674..542681) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 543101 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" CDS complement(543148..543384) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" gene complement(543148..543384) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" CDS complement(543482..544357) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" gene complement(543482..544357) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" CDS 544470..545429 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" gene 544470..545429 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" upshifts complement(544491) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" misc_feature complement(544495..544514) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(545582..546454) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" gene complement(545582..546454) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" promotor_-10 complement(546547..546552) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(546554..546555) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(546559) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 546628..546634 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 546642 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" promotor_-10 546648..546667 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 546681..548069 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" gene 546681..548069 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" downshifts 548045 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" CDS 548179..549471 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" gene 548179..549471 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" promotor_-35 549480..549486 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 549501..549520 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 549508 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" S_feature 549519..549629 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 549630..550076 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" gene 549630..550076 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" downshifts 550105 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" promotor_-35 550156..550163 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 550178..550197 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 550179 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" CDS 550313..550906 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" gene 550313..550906 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" downshifts 550949 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" downshifts complement(551025) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" promotor_-35 551038..551045 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 551059 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 551060..551079 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(551258..551917) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" gene complement(551258..551917) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" promotor_-10 complement(551966..551985) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(551973) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" promotor_-35 complement(551997..552002) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(552339..553202) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" gene complement(552339..553202) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" promotor_-35 553245..553251 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 553266..553285 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(553267..553286) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 553281 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(553291) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(553301..553308) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 553357..554748 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" gene 553357..554748 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" promotor_-35 554876..554883 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 554894..554913 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 554908 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" CDS 554942..555367 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" gene 554942..555367 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" S_feature 555368..556622 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(555420..555992) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" gene complement(555420..555992) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" downshifts complement(555425) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" S_feature complement(555993..556073) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(556074..556403) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" gene complement(556074..556403) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" misc_feature complement(556420..556439) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(556437) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" misc_feature 556611..556630 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 556624 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" CDS 556658..557530 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" gene 556658..557530 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" downshifts 557417 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" downshifts 557615 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" CDS complement(557680..558066) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" gene complement(557680..558066) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" downshifts complement(557692) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" S_feature complement(558067..558131) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 558119..558126 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(558120..558139) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(558133) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" promotor_-10 558140..558159 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 558143 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" promotor_-35 complement(558154..558161) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 558177..558770 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" gene 558177..558770 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" CDS complement(558914..560101) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" gene complement(558914..560101) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" promotor_-35 560237..560241 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 560255 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" promotor_-10 560256..560275 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 560305..560901 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" gene 560305..560901 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" CDS 561015..561200 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" gene 561015..561200 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" downshifts 561179 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" promotor_-35 561312..561315 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 561322..561508 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 561322 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" promotor_-10 561330..561349 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 561509..561844 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" gene 561509..561844 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" CDS 561857..563164 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" gene 561857..563164 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" CDS 563196..563300 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" gene 563196..563300 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo CDS 563309..563422 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" gene 563309..563422 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo promotor_-35 563608..563616 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 563627..563645 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 563644 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 563662..564447 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" gene 563662..564447 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" downshifts 563709 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" downshifts 564457 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" CDS complement(564504..565424) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" gene complement(564504..565424) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" CDS 565557..567005 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" gene 565557..567005 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" CDS complement(567123..567746) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" gene complement(567123..567746) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" promotor_-10 complement(567770..567789) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 567778..567785 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(567789) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" promotor_-10 567800..567819 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 567802 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" promotor_-35 complement(567804..567810) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 567836..568516 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" gene 567836..568516 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" downshifts 568549 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" CDS complement(568596..569039) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" gene complement(568596..569039) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" downshifts complement(568601) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" promotor_-10 complement(569062..569081) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(569086) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" promotor_-35 complement(569095..569102) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(569125..569304) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" gene complement(569125..569304) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" CDS complement(569301..569444) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" gene complement(569301..569444) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" promotor_-35 569395..569397 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 569413..569432 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 569429 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 569712..570935 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" gene 569712..570935 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" CDS 570928..571569 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" gene 570928..571569 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" downshifts 571563 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" promotor_-10 complement(571596..571615) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(571617) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(571629..571636) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 571677..571682 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 571685..573859 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" gene 571685..573859 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" upshifts 571695 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" promotor_-10 571697..571715 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(572761..572779) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(572761) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(573863..574270) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 573880..573884 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 573894 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 573897..573916 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(573908) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" CDS complement(574271..575173) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" gene complement(574271..575173) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" S_feature complement(575174..575269) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(575249..575268) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(575269) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" promotor_-35 complement(575282..575289) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(575375..576064) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" gene complement(575375..576064) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" CDS complement(576154..576966) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" gene complement(576154..576966) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" promotor_-10 complement(576995..577014) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(577008) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" promotor_-35 complement(577030..577037) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(577077..577970) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" gene complement(577077..577970) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" downshifts complement(577097) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" S_feature complement(577971..578063) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(578044..578063) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(578061) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" promotor_-35 complement(578079..578086) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 578252..578259 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 578274..578293 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 578280 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" CDS 578446..579066 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" gene 578446..579066 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" promotor_-35 578790..578796 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 578801 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" promotor_-10 578810..578828 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 579082..580020 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" gene 579082..580020 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" promotor_-35 580008..580011 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 580026..580045 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 580033..580121 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 580033 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" CDS 580122..580511 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" gene 580122..580511 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" downshifts 580502 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" misc_feature 580625..580644 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 580627..580696 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 580627 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" CDS 580697..581035 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" gene 580697..581035 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" downshifts 581023 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" CDS complement(581075..581311) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" gene complement(581075..581311) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" downshifts complement(581099) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" promotor_-35 581123..581129 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 581144..581155 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 581155 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(581312..581473) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(581477..581842) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(581517) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" CDS complement(581843..582073) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" gene complement(581843..582073) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" downshifts 582057 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" promotor_-10 complement(582094..582113) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582111) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" S_feature complement(582113..582196) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(582127..582136) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(582197..582874) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" gene complement(582197..582874) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" promotor_-10 complement(582845..582856) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582859) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" promotor_-35 complement(582871..582877) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(582875..583708) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 582890..582895 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 582910..582921 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 582915 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" CDS 582987..583694 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" gene 582987..583694 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" CDS complement(583709..584140) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" gene complement(583709..584140) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" CDS complement(584153..584395) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" gene complement(584153..584395) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" CDS complement(584409..584681) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" gene complement(584409..584681) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" promotor_-10 complement(584703..584722) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(584707) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" promotor_-35 complement(584736..584745) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 584900..584907 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 584923..584942 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 584931 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" CDS 584980..585567 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" gene 584980..585567 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" CDS 585564..585908 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" gene 585564..585908 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" S_feature 585909..586070 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 586071..586544 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" gene 586071..586544 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" S_feature 586545..587237 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(586687) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" CDS complement(586704..588347) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" gene complement(586704..588347) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" S_feature complement(588382..588579) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 588396..588398 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 588415..588433 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 588419 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts complement(588425) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" downshifts 588545 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(588571..588590) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(588583) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" promotor_-35 complement(588603..588610) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(588666) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" CDS complement(588667..590043) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" gene complement(588667..590043) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" misc_feature complement(590093..590112) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(590108) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" CDS complement(590214..590732) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" gene complement(590214..590732) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" downshifts complement(590228) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(590758..590777) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(590777) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" promotor_-35 complement(590793..590796) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 590814..590821 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 590836..590855 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 590854 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" CDS 590901..591359 /gene="ydgG" /locus_tag="BSU_05640" /old_locus_tag="BSU05640" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388445.1" /db_xref="EnsemblGenomes-Gn:BSU05640" /db_xref="EnsemblGenomes-Tr:CAB12371" /db_xref="GOA:P96705" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12174" /db_xref="UniProtKB/Swiss-Prot:P96705" /translation="MNEQKLCQAINLFVEVLLEGTEFVHREINQDVFKHISREQADLL KILKVKGPTSPGSLAMYQNVHKSAISNRLKKLLEKGLVQWDDCPEKSDRRSKLINITP SGEHILEELDSAIFNALKPLIDDIDEEHLHSIIEIFTILKSKFKGGDSAE*" gene 590901..591359 /gene="ydgG" /locus_tag="BSU_05640" /old_locus_tag="BSU05640" CDS 591356..594013 /gene="ydgH" /locus_tag="BSU_05650" /old_locus_tag="BSU05650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388446.1" /db_xref="EnsemblGenomes-Gn:BSU05650" /db_xref="EnsemblGenomes-Tr:CAB12372" /db_xref="GOA:P96706" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12175" /db_xref="UniProtKB/Swiss-Prot:P96706" /translation="MRAIIKFKWAIAAIVLALTVVLSLFSPNLTELANQKGQAQLPAD AVSERANAILKQAGEDNNSISVVFTLDNAIKKETENQLRIIIDKIKKIDGVEEVTSPL SAEKEVKDQLMSKDKKTVLMPVTITGSDKKAEKIADEIYQIVPDDLTAYITGASLINQ DFAHSSEEGLKKTEVITVCLIIGLLLIVFRSVVTPFIPIVVVGFSYLISQSILGILVY NVDFPISTFTQTFLVAILFGIGTDYCILLLTRFREELANGHDKKEAALIAYRTGGKTL FISGFAVLIGFSALGFAKFAIFQSAVGVAVGVGILMIILYTLLPLFMVTLGEKLFWPS KKVLSHSDNKLWAFLGRHSVARPFLFIVITVVITLPFILTYDDQISFDSTAEISSDYK SIKALEAIKDGFGEGKAFPINVVVKGDKDLTTADTIPYLGNISKAIEKVDHVDSVMTI TQPTGKKIKDLYIDNQLGSVSDGLDKTVKGIADVQSGLTDIENGLNQMAGQTGSASNG GSGGSLGDAADGLGKINQQLQLVSKQISQTGNTAQTVQQLTAISGQLGQIQTGLEQAN QQLSGQQAQAGTLTESLKKLSEGVKSANEGLTKVSDGITASSDILEDMSKSPTVRDTG IFIPDQVMKDKDFKKSIDQYSFADGKGVQLSVVLDSNPYSEQAITTINQIKKAVANEV DGTPLENAQIVYGGVTSMNADLKELSTTDFSRTMVIMIIGLFIVLTILFRSMIMPIYM IASLLLTYYTSISITELIFVNGLGNAGVSWAVPFFSFVILIALGVDYSIFLLDRFKEE VHLGIEQGVVRSMSKMGSVIITAAIILAGTFAAMMPSGVNTLMQVASVIIIGLLLYGL VILPLFIPAIIATFGEGNWWPFGRKKGKE*" gene 591356..594013 /gene="ydgH" /locus_tag="BSU_05650" /old_locus_tag="BSU05650" downshifts 594134 /Source="Nicolas_upshifts" /id="D272" /incds=0 /nref=3 /ntot=27 /MaxReadThrough="0.245049999999999" /MaxDrop="4.45167" /score="13.780898" /energy="-13.9" /TU="NA" /idTUdmin="U439" /TUdmin=22 /isTUend="TRUE" CDS complement(594159..594788) /gene="ydgI" /locus_tag="BSU_05660" /old_locus_tag="BSU05660" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26415543; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase of unidentified specificity (reduces 5-(aziridin-1-yl)-2,4-dinitrobenzamide prodrug)" /protein_id="NP_388447.1" /db_xref="EnsemblGenomes-Gn:BSU05660" /db_xref="EnsemblGenomes-Tr:CAB12385" /db_xref="GOA:P96707" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12176" /db_xref="UniProtKB/Swiss-Prot:P96707" /translation="MIKTNDFMEIMKGRRSIRNYDPAVKISKEEMTEILEEATTAPSS VNAQPWRFLVIDSPEGKEKLAPLASFNQTQVTTSSAVIAVFADMNNADYLEEIYSKAV ELGYMPQEVKDRQIAALTAHFEKLPAQVNRETILIDGGLVSMQLMLTARAHGYDTNPI GGYDKENIAETFGLDKERYVPVMLLSIGKAADEGYASYRLPIDTIAEWK*" gene complement(594159..594788) /gene="ydgI" /locus_tag="BSU_05660" /old_locus_tag="BSU05660" downshifts complement(594163) /Source="Nicolas_upshifts" /id="D273" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="2.66406" /MaxDrop="6.06581" /score="21.7451043" /energy="-16.6" /TU="NA" /idTUdmin="U440" /TUdmin=3 /isTUend="TRUE" CDS complement(594804..595298) /gene="ydgJ" /locus_tag="BSU_05670" /old_locus_tag="BSU05670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388448.1" /db_xref="EnsemblGenomes-Gn:BSU05670" /db_xref="EnsemblGenomes-Tr:CAB12386" /db_xref="GOA:P96708" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12177" /db_xref="UniProtKB/Swiss-Prot:P96708" /translation="MTCQSLIYQLIVLTGKKGWVLASFCSEEAEILYQLQGVNKVIGV KFEACTGISQSRLELLTLLYHADEISQSDLQKKVNIDSAAVTRHLKQLESKGMVSRRR KPEDNRITLVRLTDQGRERIESSKKEKERFMKEMLANVSAEERRLLIDVLARMRNNIN NIEA*" gene complement(594804..595298) /gene="ydgJ" /locus_tag="BSU_05670" /old_locus_tag="BSU05670" promotor_-10 complement(595290..595309) /Source="Nicolas_upshift_promotors" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(595305) /Source="Nicolas_upshifts" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" promotor_-35 complement(595325..595330) /Source="Nicolas_upshift_promotors" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 595496..595498 /Source="Nicolas_upshift_promotors" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 595514..595533 /Source="Nicolas_upshift_promotors" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 595520..595608 /Source="Nicolas_S_feature" /locus_tag="new_613552_613640" /HighExp="H2O2, G180, G135, Diami, Paraq, Oxctl, G150, LBGexp, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S199" upshifts 595520 /Source="Nicolas_upshifts" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" CDS 595609..596817 /gene="ydgK" /locus_tag="BSU_05680" /old_locus_tag="BSU05680" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388449.1" /db_xref="EnsemblGenomes-Gn:BSU05680" /db_xref="EnsemblGenomes-Tr:CAB12387" /db_xref="GOA:P96709" /db_xref="InterPro:IPR004812" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12178" /db_xref="UniProtKB/Swiss-Prot:P96709" /translation="MLHNPTGKERLALAFLLGMLAILGPLNIDMYLPSFPEIAKDLSA SASLVQLSLTACLVGLTIGQLIVGPVSDAQGRRKPLLICIFLFALSSLFCALSPNITT LVAARFLQGFTASAGLVLSRAIVRDVFTGRELSKFFSLLMVITAVAPMVAPMTGGAIL LLPFATWHTIFHVLMIIGFLLVLLIALRLKETLPLEKRIPSSIGTSVKTMGSLLKDRS FMGYALTVGFIHGGSFAYVSGTPFVYQDIYGVSPQVFSILFGINGLAIISGSFIIGRF GGIIHEKSLLRIAVITAMIATAVLLTMTMIHGPLATLVISIFIYMITIGMVLTSTFTL AMEKQGHRAGSASALLGMLPLLLGSIVSPLVGINETTAVPMGAIMFVTAVIGSLAFFG LTKERVGQNS*" gene 595609..596817 /gene="ydgK" /locus_tag="BSU_05680" /old_locus_tag="BSU05680" downshifts 596796 /Source="Nicolas_upshifts" /id="D274" /incds=0 /nref=23 /ntot=112 /MaxReadThrough="0.507390000000001" /MaxDrop="3.27202" /score="25.806679" /energy="-7.5" /TU="NA" /idTUdmin="U441" /TUdmin=0 /isTUend="TRUE" CDS complement(596853..597590) /gene="ydhB" /locus_tag="BSU_05690" /old_locus_tag="BSU05690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388450.2" /db_xref="EnsemblGenomes-Gn:BSU05690" /db_xref="EnsemblGenomes-Tr:CAB12388" /db_xref="GOA:O05493" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG12179" /db_xref="UniProtKB/Swiss-Prot:O05493" /translation="MLIILVMFLLGIILGFIGAGGAGFVIALLTLLFHIPIHTALGTS LAGMAFTSLSGAYSHYREGNIQMKIGLIVGGFAAVGSFFGAKLTSFIPADLLHYLTAG MLFLSAILILIRLFILKEKAQVNQSTLSTYTRAVILGIAAGVLSGTFGIGSAPFIQIG LMIMLNLSIRHSVGTTMLVIIPLAVGGGIGYITEGFVDYVLLVKVLVGTMCGAYVGAK FTNLMPKVVLKSAIFLTPAIAGLLLLF*" gene complement(596853..597590) /gene="ydhB" /locus_tag="BSU_05690" /old_locus_tag="BSU05690" S_feature complement(597591..597729) /Source="Nicolas_S_feature" /locus_tag="new_615623_615761_c" /HighExp="T0.30H, T1.30H, T1.0H, T-0.40H, T2.0H, T0.0H, LBGstat, T2.30H, T-1.10H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.108111" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S200" promotor_-10 complement(597717..597736) /Source="Nicolas_upshift_promotors" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(597729) /Source="Nicolas_upshifts" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" promotor_-35 complement(597750..597757) /Source="Nicolas_upshift_promotors" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 597761..597768 /Source="Nicolas_upshift_promotors" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 597782..597801 /Source="Nicolas_upshift_promotors" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 597786 /Source="Nicolas_upshifts" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" CDS 597839..598513 /gene="ydhC" /locus_tag="BSU_05700" /old_locus_tag="BSU05700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388451.1" /db_xref="EnsemblGenomes-Gn:BSU05700" /db_xref="EnsemblGenomes-Tr:CAB12389" /db_xref="GOA:O05494" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12180" /db_xref="UniProtKB/Swiss-Prot:O05494" /translation="MDDFKLDKPTPYYLQFYNQLKKMIFNGTFKPGERINETQLAKSF GVSRSPIREAMRLLEKDGLLKADDRNGFSITSLTAKDVDEIYKIRIPLEQLAVELVID EADEEELTILEKQLEETEKAIHNGTEDTEIIRLNQKFHELLVDFSHNRHLKNLLEHVN DLIHFCRILNYTGDHRAETILREHRRIFEEVKKKNKEAAKQHVLAHFNHDCEHLKHVL EEGKEN*" gene 597839..598513 /gene="ydhC" /locus_tag="BSU_05700" /old_locus_tag="BSU05700" promotor_-35 598572..598577 /Source="Nicolas_upshift_promotors" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 598593..598611 /Source="Nicolas_upshift_promotors" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 598599 /Source="Nicolas_upshifts" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" CDS 598640..599902 /gene="spoL" /locus_tag="BSU_05710" /old_locus_tag="BSU05710" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11011148, 12177332; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore cortex lytic enzyme" /protein_id="NP_388452.2" /db_xref="EnsemblGenomes-Gn:BSU05710" /db_xref="EnsemblGenomes-Tr:CAB12390" /db_xref="GOA:O05495" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:3CZ8" /db_xref="SubtiList:BG12181" /db_xref="UniProtKB/Swiss-Prot:O05495" /translation="MFIHIVGPGDSLFSIGRRYGASVDQIRGVNGLDETNIVPGQALL IPLYVYTVQPRDTLTAIAAKAFVPLERLRAANPGISPNALQAGAKITIPSISNYIAGT LSFYVLRNPDLDRELINDYAPYSSSISIFEYHIAPNGDIANQLNDAAAIETTWQRRVT PLATITNLTSGGFSTEIVHQVLNNPTARTNLVNNIYDLVSTRGYGGVTIDFEQVSAAD RDLFTGFLRQLRDRLQAGGYVLTIAVPAKTSDNIPWLRGYDYGGIGAVVNYMFIMAYD WHHAGSEPGPVAPITEIRRTIEFTIAQVPSRKIIIGVPLYGYDWIIPYQPGTVASAIS NQNAIERAMRYQAPIQYSAEYQSPFFRYSDQQGRTHEVWFEDVRSMSRKMQIVREYRL QAIGAWQLTLGFTPGPWLLRKFFTIRKV*" gene 598640..599902 /gene="spoL" /locus_tag="BSU_05710" /old_locus_tag="BSU05710" downshifts 599876 /Source="Nicolas_upshifts" /id="D275" /incds=0 /nref=33 /ntot=81 /MaxReadThrough="2.3134" /MaxDrop="5.20337" /score="15.7593331" /energy="-7.1" /TU="NA" /idTUdmin="U444" /TUdmin=0 /isTUend="TRUE" promotor_-35 599974..599981 /Source="Nicolas_upshift_promotors" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 599995..600014 /Source="Nicolas_upshift_promotors" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 599999 /Source="Nicolas_upshifts" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" CDS 600063..601250 /gene="ydhE" /locus_tag="BSU_05720" /old_locus_tag="BSU05720" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388453.2" /db_xref="EnsemblGenomes-Gn:BSU05720" /db_xref="EnsemblGenomes-Tr:CAB12391" /db_xref="GOA:O05496" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG12182" /db_xref="UniProtKB/Swiss-Prot:O05496" /translation="MKTVLILNFPAEGHVNPTLGITKAFSDKGYDVHYISTEKYKKRL EAAGATVHLHRDLLRTTPIHVGSPNGILDFVKIHIKTSLDILQIVKDLSKSIQFDFVY YDKFGAGELVRDYLDIPGVSSSASFLFGEEHLKILPLHPESGAPLELDQECEDLLAKM KETYGVAPKNLVQFMNNKGELNVVYTSRYFQPESDRFGDECLFIGPSFPKRAEKTDFP IEQLKDEKVIYISMGTVLDHTEDFFNLCIDAFSGFNGKVVIAAGEKADLTKLKQAPEN FIIAPYVPQLEVLEQSDVFITHGGMNSVNEGIHFSVPLVVMPHDKDQPMVAQRLSELH AGYVISKDEVNAQILKQAVDEVLRNDQYTAGIKKINQSFKECMDMEEVMERIDELIRQ KNK*" gene 600063..601250 /gene="ydhE" /locus_tag="BSU_05720" /old_locus_tag="BSU05720" downshifts 601262 /Source="Nicolas_upshifts" /id="D276" /incds=0 /nref=17 /ntot=224 /MaxReadThrough="1.77672" /MaxDrop="5.25325" /score="-6.36206618" /energy="-12.6" /TU="NA" /idTUdmin="U445" /TUdmin=1 /isTUend="TRUE" CDS complement(601289..601999) /gene="ydhF" /locus_tag="BSU_05730" /old_locus_tag="BSU05730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913081, 11557812; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative phosphate-starvation lipoprotein" /protein_id="NP_388454.1" /db_xref="EnsemblGenomes-Gn:BSU05730" /db_xref="EnsemblGenomes-Tr:CAB12392" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12183" /db_xref="UniProtKB/Swiss-Prot:O05497" /translation="MRRILSILVFAIMLAGCSSNASTEKQHAGGEKTVKAEPQSTSSQ KDSTDDYQPNSQVTDDRTLHKVGQTFSDDKGKAVLKDIKQVNKTYKIGDVELTVKEMK LIHLRPDYSMIDYFHELTHDEEFDFVKVFVDIKNTSTKKVNVAPIALMKTNTGETFDW NKDIYLEELNGELEGGAEKSGNLGFIVNASSGHAHDKAADAEKKTKEIKWIEITTSDV FDHNHKKISDAQKIKIKF*" gene complement(601289..601999) /gene="ydhF" /locus_tag="BSU_05730" /old_locus_tag="BSU05730" downshifts complement(601315) /Source="Nicolas_upshifts" /id="D277" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="4.05808" /MaxDrop="4.7318" /score="13.7192471" /energy="-12.6" /TU="NA" /idTUdmin="U446" /TUdmin=0 /isTUend="TRUE" CDS complement(602065..603453) /gene="phoB" /locus_tag="BSU_05740" /old_locus_tag="BSU05740" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9335276, 10913081, 16030210, 16491025, 26382712, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9335276, 10913081, 16030210, 16491025, 26382712, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase III (promiscuous, heptaprenylglyceryl phosphate is a substrate)" /protein_id="NP_388455.2" /db_xref="EnsemblGenomes-Gn:BSU05740" /db_xref="EnsemblGenomes-Tr:CAB12393" /db_xref="GOA:P19405" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10697" /db_xref="UniProtKB/Swiss-Prot:P19405" /translation="MKKFPKKLLPIAVLSSIAFSSLASGSVPEASAQEKKKGNQDEIK NVIVLIGDGMGVSYTSAYRYLKDNKKTKVVEPTAFDQYLVGQQTTYPDDPEQNVTDSA AAATAMSAGIKTYNNAIAVDNDGSEAKTVLEAAKEKGKATGLVATSEITHATPASFGS HDHSRKNMNSIADDYFDEMVNGKHKIDVLLGGGKSNFDRKDRNLIKEFKKAGYSYVDD RKDMLKNKDSQVLGLFADGGLPKKIDRTKDIPSLKDMTNTAIKKLNKDKDGFFLMVEG SQIDWAGHDNDIVGAMSEMEDFEQAYKAAIDFAKKDKHTLVVATADHSTGGYSIGADG IYNWFSEPIKAAKRTPDFMAEKIADGADVEKTLKTYIDQKKLALTKAEIQSVEEAAKS KEVLDIDNAIENIFNKRSHTGWTTGGHTGEDVPVYAYGPSSETFAGQIDNTEIAKNVF KALQYNIKINDK*" gene complement(602065..603453) /gene="phoB" /locus_tag="BSU_05740" /old_locus_tag="BSU05740" promotor_-10 complement(603510..603527) /Source="Nicolas_upshift_promotors" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(603511) /Source="Nicolas_upshifts" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" S_feature complement(603513..603581) /Source="Nicolas_S_feature" /locus_tag="new_621545_621613_c" /HighExp="S6, S4, S5, S3, S7, LoTm, S8, T5.0H, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S201" promotor_-35 complement(603534..603541) /Source="Nicolas_upshift_promotors" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(603571..603589) /Source="Nicolas_upshift_promotors" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(603589) /Source="Nicolas_upshifts" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" promotor_-35 complement(603605..603610) /Source="Nicolas_upshift_promotors" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 603658..603665 /Source="Nicolas_upshift_promotors" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 603679..603698 /Source="Nicolas_upshift_promotors" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 603681..603814 /Source="Nicolas_S_feature" /locus_tag="new_621713_621846" /HighExp="Diami, dia15, H2O2, Paraq, Oxctl, HPh, G180, G135, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S202" upshifts 603681 /Source="Nicolas_upshifts" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" CDS 603815..604186 /gene="fra" /locus_tag="BSU_05750" /old_locus_tag="BSU05750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:20087498, 21744456, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20087498, 21744456, 25826316; Product type f: factor" /codon_start=1 /transl_table=11 /product="frataxin; iron/sulfur chaperone" /protein_id="NP_388456.1" /db_xref="EnsemblGenomes-Gn:BSU05750" /db_xref="EnsemblGenomes-Tr:CAB12394" /db_xref="GOA:Q797E6" /db_xref="InterPro:IPR014922" /db_xref="PDB:2OC6" /db_xref="SubtiList:BG12184" /db_xref="UniProtKB/Swiss-Prot:Q797E6" /translation="MDVFSEYLAGIADPFHRERTEEVLTWIKNKYPNLHTEIKWNQPM FTDHGTFIIGFSVSKKHLAVAPEKVTIAHVEDDIVKAGYDYTEQLIRIPWNGPVDYTL LEKMIEFNILDKADCSTFWRK*" gene 603815..604186 /gene="fra" /locus_tag="BSU_05750" /old_locus_tag="BSU05750" downshifts 604165 /Source="Nicolas_upshifts" /id="D278" /incds=0 /nref=9 /ntot=150 /MaxReadThrough="2.88587" /MaxDrop="3.59127" /score="28.8500849" /energy="-8.1" /TU="NA" /idTUdmin="U448" /TUdmin=0 /isTUend="TRUE" downshifts complement(604260) /Source="Nicolas_upshifts" /id="D279" /incds=0 /nref=9 /ntot=187 /MaxReadThrough="1.63268" /MaxDrop="2.98181" /score="0.51805655" /energy="-13" /TU="NA" /idTUdmin="U450" /TUdmin=2 /isTUend="TRUE" CDS complement(604261..604758) /gene="ydhH" /locus_tag="BSU_05760" /old_locus_tag="BSU05760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388457.1" /db_xref="EnsemblGenomes-Gn:BSU05760" /db_xref="EnsemblGenomes-Tr:CAB12395" /db_xref="GOA:O05500" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG12185" /db_xref="UniProtKB/Swiss-Prot:O05500" /translation="MSSHYKYPLIFTAFLLIAFCLIFFSYHLIHHVRLEYPNWQGESK DQNWEAVFTKNEDAPNEYSGKLYWIGDTIEIDNTYLESLIVKKDDEVLLSSDTEIPMH DYAGGTFSDGSAKEKSVSFLERLDEHELEGHDITIEVKWKQGNHYSASQLTLNEKTLF DEKQQ*" gene complement(604261..604758) /gene="ydhH" /locus_tag="BSU_05760" /old_locus_tag="BSU05760" CDS complement(604776..605258) /gene="ydhI" /locus_tag="BSU_05770" /old_locus_tag="BSU05770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388458.1" /db_xref="EnsemblGenomes-Gn:BSU05770" /db_xref="EnsemblGenomes-Tr:CAB12396" /db_xref="GOA:O05501" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12186" /db_xref="UniProtKB/Swiss-Prot:O05501" /translation="MMIIIPNNEIAKHMLTDFFAKHWGTPEMAISSGIFRCDELDGFA AVNESGEIIGCITYTIDGKDCEIISLDSMIENKGIGTALLQQVEEKAKHAHCQRIKLI TTNDNVNAIAFYQKRGYQFAAVFPNAVEKARRLKPEIPEVAENGILIRDEILFSKVID *" gene complement(604776..605258) /gene="ydhI" /locus_tag="BSU_05770" /old_locus_tag="BSU05770" promotor_-35 604931..604938 /Source="Nicolas_upshift_promotors" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 604952..604971 /Source="Nicolas_upshift_promotors" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 604956 /Source="Nicolas_upshifts" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(605287..605306) /Source="Nicolas_upshift_promotors" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(605297) /Source="Nicolas_upshifts" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" promotor_-35 complement(605321..605324) /Source="Nicolas_upshift_promotors" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 605341..606318 /gene="ydhJ" /locus_tag="BSU_05780" /old_locus_tag="BSU05780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_388459.1" /db_xref="EnsemblGenomes-Gn:BSU05780" /db_xref="EnsemblGenomes-Tr:CAB12397" /db_xref="GOA:O05502" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG12187" /db_xref="UniProtKB/Swiss-Prot:O05502" /translation="MEISDIIYGQHHIDGVLEELIKSAPVQRLKGIYQGGASFLVNRK WNVTRYEHSIGVMLLIKKLGGTIEEQIAGLLHDVSHTAFSHVVDVVFENQAEDYHENI FQQVIVHSEIPDILQKHGYHTEELLSDDSRWTLLEQPAPELCADRTDYTLRDMYRYGH INLHEAQTFLDHLIVRNGRMFPDSIEAAEWFVSVYYKEVIDFFLNPVNVYGYEYLARA LKAALRHDVISAEDLLKTDQEVLNILRASKNEEVLSLLTSIHPGIQVIEDDIQYDFHQ KKKMRLIDPSIFLDDKWIKSSGVSEKVRKMGEAAYQKAKKGVYIKILKQ*" gene 605341..606318 /gene="ydhJ" /locus_tag="BSU_05780" /old_locus_tag="BSU05780" downshifts 606298 /Source="Nicolas_upshifts" /id="D280" /incds=0 /nref=2 /ntot=92 /MaxReadThrough="2.31799" /MaxDrop="3.19063" /score="28.8500849" /energy="-8.1" /TU="NA" /idTUdmin="U451" /TUdmin="-770" /isTUend="FALSE" promotor_-35 606345..606351 /Source="Nicolas_upshift_promotors" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 606366..606384 /Source="Nicolas_upshift_promotors" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 606374 /Source="Nicolas_upshifts" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" promotor_-35 606410..606417 /Source="Nicolas_upshift_promotors" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 606430 /Source="Nicolas_upshifts" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" promotor_-10 606431..606450 /Source="Nicolas_upshift_promotors" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 606460..607077 /gene="ydhK" /locus_tag="BSU_05790" /old_locus_tag="BSU05790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388460.1" /db_xref="EnsemblGenomes-Gn:BSU05790" /db_xref="EnsemblGenomes-Tr:CAB12398" /db_xref="InterPro:IPR011438" /db_xref="PDB:2KY9" /db_xref="PDB:4FIB" /db_xref="PDB:4MDW" /db_xref="SubtiList:BG12188" /db_xref="UniProtKB/Swiss-Prot:O05503" /translation="MSAGKSYRKKMKQRRMNMKISKYALGILMLSLVFVLSACGNNNS TKESTHDNHSDSSTHEEMDHSGSADVPEGLQESKNPKYKVGSQVIINTSHMKGMKGAE ATVTGAYDTTAYVVSYTPTNGGQRVDHHKWVIQEEIKDAGDKTLQPGDQVILEASHMK GMKGATAEIDSAEKTTVYMVDYTSTTSGEKVKNHKWVTEDELSAK*" gene 606460..607077 /gene="ydhK" /locus_tag="BSU_05790" /old_locus_tag="BSU05790" downshifts 607064 /Source="Nicolas_upshifts" /id="D281" /incds=0 /nref=62 /ntot=212 /MaxReadThrough="1.07295" /MaxDrop="7.27889" /score="30.3859931" /energy="-11.4" /TU="U452" /idTUdmin="U451" /TUdmin="-4" /isTUend="TRUE" CDS complement(607093..608259) /gene="pbuE" /locus_tag="BSU_05800" /old_locus_tag="BSU05800" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12923093, 15849754, 16850406, 17935948, 25573585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15849754, 16850406, 17935948, 25573585; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine efflux transporter" /protein_id="NP_388461.2" /db_xref="EnsemblGenomes-Gn:BSU05800" /db_xref="EnsemblGenomes-Tr:CAB12399" /db_xref="GOA:Q797E3" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12189" /db_xref="UniProtKB/Swiss-Prot:Q797E3" /translation="MNFKVFLLAASTIAVGLVELIVGGILPQIANDLDISIVSAGQLI SVFALGYAVSGPLLLALTAKIERKRLYLIALFVFFLSNLVAYFSPNFATLMVSRVLAA MSTGLIVVLSLTIAPKIVAPEYRARAIGIIFMGFSSAIALGVPLGILISDSFGWRILF LGIGLLALISMLIISIFFERIPAEKMIPFREQLKTIGNLKIASSHLVTMFTLAGHYTL YAYFAPFLEETLHLSSFWVSICYFLFGISAVCGGPFGGALSDRLGSFKSILLVTGSFA IIMFLLPLSTSSMIFFLPVMVIWGLLSWSLAPAQQSYLIEIAPDSSDIQQSFNTSALQ VGIALGSAIGGVVLDQTGTVVSTAWCGGSIVIIAVLFAFISLTRPVQTAKKSSL*" gene complement(607093..608259) /gene="pbuE" /locus_tag="BSU_05800" /old_locus_tag="BSU05800" downshifts complement(607122) /Source="Nicolas_upshifts" /id="D282" /incds=0 /nref=40 /ntot=58 /MaxReadThrough="2.22188" /MaxDrop="4.89202" /score="36.362851" /energy="-12.4" /TU="NA" /idTUdmin="U453" /TUdmin=0 /isTUend="TRUE" misc_RNA complement(608314..608414) /gene="aswA" /locus_tag="BSU_misc_RNA_8" /product="adenine riboswitch" /experiment="publication(s) with functional evidences, PMID:14718920, 16201765, 19603494, 20022916, 21283784, 23087247, 25573585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14718920, 16201765, 19603494, 20022916, 21283784, 23087247, 25573585; Product type n: RNA" gene complement(608314..608414) /gene="aswA" /locus_tag="BSU_misc_RNA_8" downshifts complement(608355) /Source="Nicolas_upshifts" /id="D283" /incds=0 /nref=38 /ntot=127 /MaxReadThrough="5.85661" /MaxDrop="6.06248" /score="33.0784595" /energy="-19.4" /TU="U453" /idTUdmin="U453" /TUdmin="-1233" /isTUend="FALSE" promotor_-10 complement(608424..608443) /Source="Nicolas_upshift_promotors" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(608438) /Source="Nicolas_upshifts" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" promotor_-35 complement(608459..608463) /Source="Nicolas_upshift_promotors" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 608522..608529 /Source="Nicolas_upshift_promotors" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 608543..608562 /Source="Nicolas_upshift_promotors" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 608550 /Source="Nicolas_upshifts" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" CDS 608590..608901 /gene="gmuB" /locus_tag="BSU_05810" /old_locus_tag="BSU05810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18177310; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIB" /protein_id="NP_388462.1" /db_xref="EnsemblGenomes-Gn:BSU05810" /db_xref="EnsemblGenomes-Tr:CAB12400" /db_xref="GOA:O05505" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG12190" /db_xref="UniProtKB/Swiss-Prot:O05505" /translation="MKKILLACSSGMSTSLLVTKMKEYAQSIGEEAEIWAVGQDKAKE DMRKADAVLIGPQMSFLKSELQKEADQYNIQVEVIDMMAYGMADGKKAYEQALSLMVN Q*" gene 608590..608901 /gene="gmuB" /locus_tag="BSU_05810" /old_locus_tag="BSU05810" CDS 608901..609233 /gene="gmuA" /locus_tag="BSU_05820" /old_locus_tag="BSU05820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIA" /protein_id="NP_388463.2" /db_xref="EnsemblGenomes-Gn:BSU05820" /db_xref="EnsemblGenomes-Tr:CAB12401" /db_xref="GOA:O05506" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG12191" /db_xref="UniProtKB/Swiss-Prot:O05506" /translation="MEQMKITNLTDEQISFQLILHSGNARSCIIQSLRAYKEGKKDEA DALIAKAEQDLSAAHDIHFQMIQKESGGEATAFSLLLMHAEDHLMSTLSMKELVKEML DLFKTKNI*" gene 608901..609233 /gene="gmuA" /locus_tag="BSU_05820" /old_locus_tag="BSU05820" CDS 609252..610580 /gene="gmuC" /locus_tag="BSU_05830" /old_locus_tag="BSU05830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18177310; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIC" /protein_id="NP_388464.1" /db_xref="EnsemblGenomes-Gn:BSU05830" /db_xref="EnsemblGenomes-Tr:CAB12402" /db_xref="GOA:O05507" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG12192" /db_xref="UniProtKB/Swiss-Prot:O05507" /translation="MFEKISQFLVPIAGRLNNNRYLQVLRDAFMLAFPLTIFGSIFVV LTNLPFLNKIMNASMLTSFQSHFGIASTATMGIMSVFVVFGIGYYLSKSYQVEAVFGG AIALVSFLLLTPFIIQPETGDAITGVIPVDRLGAKGMFLGMITAFLSGEIYRRIVQKN LTIKMPAGVPPAVAKSFAALIPAFITLTVFLLINVMVTLFFKTNMHDVIYHAIQAPLV GLGSGIIPTLIAVFFIQILWFFGLHGQIIINSVMDPIWNTLQVENLSAYTAGKEIPHI ISKPFMEIYTVGMGGTGMTLAIVFTILIFMKSRQMKQVSKLGLAPGIFNVNEPIIFGL PIVMNPIIIVPWVLAPMVVTLVTYLAMSAGLVPPPTGVTVPWTVPLFINGIMATNSIM GGVMQLINLLIVFVIWFPFLKAMDKLNLAKEKEQAVQETAAQQNDNSIKM*" gene 609252..610580 /gene="gmuC" /locus_tag="BSU_05830" /old_locus_tag="BSU05830" CDS 610598..611995 /gene="gmuD" /locus_tag="BSU_05840" /old_locus_tag="BSU05840" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18177310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18177310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannoside-phospho-beta-d-glucosidase" /protein_id="NP_388465.1" /db_xref="EnsemblGenomes-Gn:BSU05840" /db_xref="EnsemblGenomes-Tr:CAB12403" /db_xref="GOA:O05508" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="SubtiList:BG12193" /db_xref="UniProtKB/Swiss-Prot:O05508" /translation="MAHTEQYRFPKDFWWGSSASATQMEGAADRDGKGQNIWDYWFEK EPHRFFDHVGPADTSQFYDNYKEDIRLMKELGHNSFRMSISWSRLIPNGTGEINDKAA DFYNNVIDELIANGIEPFVNLFHFDMPMALQKIGGWVNRETVDAYENYARTCFRLFGG RVKKWFTHNEPIVPVEGGYLYDFHYPNKVDFKEAVQVGFHTMLSSARAIQAYREMKQD GKIGIILNLTPSYPRSSHPADVKAGEIADAFFNRSFLDPSVKGEFPKELVDILKHEGF MPDYNAEDLDIIKKNTVDLLGVNYYQPRRVKAKEHLPNPDAPFLPDRYFDPYVMPGRK MNPHRGWEIYEKGVYDILINLKENYGNIECFISENGMGVEGEERFRDEQGIIQDDYRI EFIKEHLKWIHRAIQEGSNVKGYHLWTFMDNWSWTNAYKNRYGFVSVNLEKDGERTVK KSGKWFKEVAEHSGF*" gene 610598..611995 /gene="gmuD" /locus_tag="BSU_05840" /old_locus_tag="BSU05840" S_feature 611996..612082 /Source="Nicolas_S_feature" /locus_tag="new_630028_630114" /HighExp="G150, T0.30H, T1.0H, M40t90, T1.30H, Mt0, M0t90, Lbexp, dia0, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S203" promotor_-35 612060..612067 /Source="Nicolas_upshift_promotors" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 612081..612100 /Source="Nicolas_upshift_promotors" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 612084 /Source="Nicolas_upshifts" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" CDS 612138..612851 /gene="gmuR" /locus_tag="BSU_05850" /old_locus_tag="BSU05850" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18177310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18177310; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388466.1" /db_xref="EnsemblGenomes-Gn:BSU05850" /db_xref="EnsemblGenomes-Tr:CAB12404" /db_xref="GOA:O05509" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12194" /db_xref="UniProtKB/Swiss-Prot:O05509" /translation="MNKYEIIANEMRNRIKNNVYPIDQPIPDEVSLAKEFNSSRMTMK RALDNLVAEGLLFRKRGHGTFIIQSAIQDDHVHVVSNEILGLTNLLKDKKIKSKVIQF EVQFPTEEVAAHLSIDQKTPVYYVVRLRIVEGEPYVLEKTYMPTHLIPGINDDVLHDS IYNHITNVLQLKIAGTHRKIRACKSDHIDQQHLGCKQDDPILEVEHVGFLDTGIPFEY SFSRHRHDKFVVTSVNIRR*" gene 612138..612851 /gene="gmuR" /locus_tag="BSU_05850" /old_locus_tag="BSU05850" CDS 612880..613779 /gene="gmuE" /locus_tag="BSU_05860" /old_locus_tag="BSU05860" /EC_number="2.7.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15018644, 18177310, 21185308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15018644, 18177310, 21185308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ROK fructokinase; glucomannan utilization protein E" /protein_id="NP_388467.1" /db_xref="EnsemblGenomes-Gn:BSU05860" /db_xref="EnsemblGenomes-Tr:CAB12405" /db_xref="GOA:O05510" /db_xref="InterPro:IPR000600" /db_xref="PDB:1XC3" /db_xref="PDB:3LM9" /db_xref="PDB:3OHR" /db_xref="SubtiList:BG12195" /db_xref="UniProtKB/Swiss-Prot:O05510" /translation="MLGGIEAGGTKFVCAVGREDGTIIDRIEFPTKMPDETIEKVIQY FSQFSLQAIGIGSFGPVDNDKTSQTYGTITATPKAGWRHYPFLQTVKNEMKIPVGFST DVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLSHPEMGHIYIRRHP DDVYQGKCPYHGDCFEGLASGPAIEARWGKKAADLSDIAQVWELEGYYIAQALAQYIL ILAPKKIILGGGVMQQKQVFSYIYQYVPKIMNSYLDFSELSDDISDYIVPPRLGSNAG IIGTLVLAHQALQAEAASGEVRS*" gene 612880..613779 /gene="gmuE" /locus_tag="BSU_05860" /old_locus_tag="BSU05860" CDS 613776..614723 /gene="gmuF" /locus_tag="BSU_05870" /old_locus_tag="BSU05870" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10704478, 18177310, 3017192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphohexomutase; cupin family" /protein_id="NP_388468.1" /db_xref="EnsemblGenomes-Gn:BSU05870" /db_xref="EnsemblGenomes-Tr:CAB12406" /db_xref="GOA:O05511" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG12196" /db_xref="UniProtKB/Swiss-Prot:O05511" /translation="MTHPLFLEPVFKERLWGGTKLRDAFGYAIPSQKTGECWAVSAHA HGSSSVKNGPLAGKTLDQVWKDHPEIFGFPDGKVFPLLVKLLDANMDLSVQVHPDDDY AKLHENGDLGKTECWYIIDCKDDAELILGHHASTKEEFKQRIESGDWNGLLRRIKIKP GDFFYVPSGTLHALCKGTLVLEIQQNSDTTYRVYDYDRCNDQGQKRTLHIEKAMEVIT IPHIDKVHTPEVKEVGNAEIIVYVQSDYFSVYKWKISGRAAFPSYQTYLLGSVLSGSG RIINNGIQYECNAGSHFILPAHFGEFTIEGTCEFMISHP*" gene 613776..614723 /gene="gmuF" /locus_tag="BSU_05870" /old_locus_tag="BSU05870" CDS 614742..615830 /gene="gmuG" /locus_tag="BSU_05880" /old_locus_tag="BSU05880" /EC_number="3.2.1.78" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2694961, 7727534, 18177310, 28101462, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2694961, 7727534, 18177310, 28101462, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported mannan endo-1,4-beta-mannosidase" /protein_id="NP_388469.2" /db_xref="EnsemblGenomes-Gn:BSU05880" /db_xref="EnsemblGenomes-Tr:CAB12407" /db_xref="GOA:O05512" /db_xref="InterPro:IPR000805" /db_xref="InterPro:IPR016714" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR022790" /db_xref="PDB:2WHK" /db_xref="PDB:3CBW" /db_xref="SubtiList:BG12197" /db_xref="UniProtKB/Swiss-Prot:O05512" /translation="MFKKHTISLLIIFLLASAVLAKPIEAHTVSPVNPNAQQTTKTVM NWLAHLPNRTENRVLSGAFGGYSHDTFSMAEADRIRSATGQSPAIYGCDYARGWLETA NIEDSIDVSCNGDLMSYWKNGGIPQISLHLANPAFQSGHFKTPITNDQYKKILDSSTV EGKRLNAMLSKIADGLQELENQGVPVLFRPLHEMNGEWFWWGLTSYNQKDNERISLYK QLYKKIYHYMTDTRGLDHLIWVYSPDANRDFKTDFYPGASYVDIVGLDAYFQDAYSIN GYDQLTALNKPFAFTEVGPQTANGSFDYSLFINAIKQKYPKTIYFLAWNDEWSAAVNK GASALYHDSWTLNKGEIWNGDSLTPIVE*" gene 614742..615830 /gene="gmuG" /locus_tag="BSU_05880" /old_locus_tag="BSU05880" downshifts 615824 /Source="Nicolas_upshifts" /id="D284" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="1.56881" /MaxDrop="2.87204" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U454" /TUdmin=0 /isTUend="TRUE" CDS complement(615891..616619) /gene="ydhUc" /locus_tag="BSU_05890" /old_locus_tag="BSU05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTFRETLAFLIVRDNAHQNAFAKALETLGVEWAKL LPVPNYDINKYPECRKYVELGYHNTHFNFRLDETRISEIYQGKSPSRNGGELQVIDPP AGFPVPVLPEIPNEHSPGLGDMNA*" gene complement(615891..616619) /gene="ydhUc" /locus_tag="BSU_05890" /old_locus_tag="BSU05890" /pseudo downshifts complement(615941) /Source="Nicolas_upshifts" /id="D285" /incds=0 /nref=13 /ntot=37 /MaxReadThrough="1.1517" /MaxDrop="5.0503" /score="0.317473754" /energy="-17.6" /TU="NA" /idTUdmin="U456" /TUdmin=3 /isTUend="TRUE" CDS complement(616550..616744) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" gene complement(616550..616744) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo promotor_-10 complement(616777..616788) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(616785) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" promotor_-35 complement(616802..616808) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 616863..616870 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 616884..616903 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 616886..616986 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 616888 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" downshifts complement(616934) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" upshifts 616946 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" promotor_-35 616954..616961 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 616975..616994 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 616990..617077 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 616990 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" tRNA 617078..617154 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 617078..617154 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" tRNA 617168..617241 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 617168..617241 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" rRNA 617401..618955 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 617401..618955 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" rRNA 619123..622050 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 619123..622050 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" rRNA 622106..622222 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 622106..622222 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" tRNA 622236..622312 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 622236..622312 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" tRNA 622373..622449 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 622373..622449 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" downshifts 622446 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" promotor_-35 622550..622554 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 622570..622589 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 622574 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" CDS 622630..623607 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" gene 622630..623607 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" CDS 623622..624098 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" gene 623622..624098 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" CDS 624079..624768 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" gene 624079..624768 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" CDS 624778..625233 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" gene 624778..625233 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" CDS 625226..626266 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" gene 625226..626266 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" downshifts 626230 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" CDS complement(626496..628424) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" gene complement(626496..628424) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" downshifts complement(626513) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" misc_feature 628176..628195 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 628186 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" S_feature 628188..628377 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 628342..628349 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 628363..628382 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 628379..628549 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 628379 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" promotor_-10 complement(628444..628463) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(628456) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" promotor_-35 complement(628477..628484) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 628550..629062 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" gene 628550..629062 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" CDS 629059..629706 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" gene 629059..629706 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" promotor_no_box 629536..629636 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 629596 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" CDS 629728..629901 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" gene 629728..629901 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" CDS 629908..630672 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" gene 629908..630672 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" downshifts 630652 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" CDS complement(630710..630901) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" gene complement(630710..630901) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" downshifts complement(630727) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" CDS complement(630898..631632) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" gene complement(630898..631632) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" promotor_-35 631290..631295 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 631310..631328 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 631312 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 631631..631632 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 631642..631656 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 631664 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" promotor_-10 complement(631669..631688) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 631686..631794 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(631689) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" promotor_-35 complement(631702..631707) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 631768..631774 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 631788..631807 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 631796..631870 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 631796 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" CDS 631871..632155 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" gene 631871..632155 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" CDS 632202..633836 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" gene 632202..633836 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" S_feature 633837..633929 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 633886 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" CDS complement(633924..634052) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" gene complement(633924..634052) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo S_feature 633931..635399 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(634055..634213) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" gene complement(634055..634213) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo CDS complement(634258..634386) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" gene complement(634258..634386) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo CDS complement(634479..634688) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" gene complement(634479..634688) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo CDS complement(634681..634986) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " gene complement(634681..634986) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo CDS 635400..635780 /gene="ydiM" /locus_tag="BSU_06040" /old_locus_tag="BSU06040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; prophage 3 region" /protein_id="NP_388485.1" /db_xref="EnsemblGenomes-Gn:BSU06040" /db_xref="EnsemblGenomes-Tr:CAB12423" /db_xref="SubtiList:BG12785" /db_xref="UniProtKB/Swiss-Prot:O34672" /translation="MLSDNNFVSETLENVQYLLPGAKVIKLRGYSRAHKVYTIAKSPV EKWKVAAGLSGSEIAILIRKGHWIGASIPAGGIVIDIDDSKQGELVKGLLDAQNFHCH CIRTLMGGSLFLRITNMGKRKLNK*" gene 635400..635780 /gene="ydiM" /locus_tag="BSU_06040" /old_locus_tag="BSU06040" S_feature 635781..636038 /Source="Nicolas_S_feature" /locus_tag="new_653813_654070" /HighExp="H2O2, dia15, S1, Heat, G150, Diami, G135, G180, S2, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.1454" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S211" CDS 636039..636311 /gene="ydzU" /locus_tag="BSU_06048" /old_locus_tag="BSU06048" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; prophage 3 region" /protein_id="YP_003097688.1" /db_xref="EnsemblGenomes-Gn:BSU06048" /db_xref="EnsemblGenomes-Tr:CAX52567" /db_xref="UniProtKB/Swiss-Prot:C0H3W7" /translation="MKAWKVEPYEISKAMELIYKYLLLDKKDFSLEEFYKLTIYAIKW KLEQAQFPLYLESTKKSHQNVIPQPFKIKGNVLYKTVIKNSGDFEE*" gene 636039..636311 /gene="ydzU" /locus_tag="BSU_06048" /old_locus_tag="BSU06048" CDS 636301..636660 /gene="ydzV" /locus_tag="BSU_06049" /old_locus_tag="BSU06049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage terminase (fragment); defective prophage 3" /db_xref="PSEUDO:CAX52568.1" /translation="MKNSSSWRVGVIHPFKKLSNIERNSVHYELASNDNGREKKDIVP ASVISPSGSCFSLADNGLVEKEGQKMKLTERQRRFCDFFTETRNTTEATRLAGNKGKN LNRVASQNLSKLDIQTI*" gene 636301..636660 /gene="ydzV" /locus_tag="BSU_06049" /old_locus_tag="BSU06049" /pseudo S_feature 636661..637104 /Source="Nicolas_S_feature" /locus_tag="new_654693_655136" /HighExp="H2O2, dia15, S1, G180, G135, G150, Heat, Diami, S2, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S212" CDS 636946..637161 /gene="ydiN" /locus_tag="BSU_06050" /old_locus_tag="BSU06050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative N-terminus of restriction enzyme; defective prophage 3" /db_xref="PSEUDO:SOX90546.1" /translation="MIKFSVILGMIRCSLTHITTKNTVNALKRMIYPKQKPSFFHEFK VLYKLLKKFCIKGIMIKNIRSCMGYFL*" gene 636946..637161 /gene="ydiN" /locus_tag="BSU_06050" /old_locus_tag="BSU06050" /pseudo promotor_-35 637091..637097 /Source="Nicolas_upshift_promotors" /id="U469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig="0.997002997002997" /xcortree=1874 /SigmaFactorBS="agcaaaaaccttcattctttcatgaatttaaagtattatata agcTACTGAAaaagttttgtataAAAGGTATAATGATAAAGAAcattcgttcttgtat g" /listShort="S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 637106..637190 /Source="Nicolas_S_feature" /locus_tag="new_655138_655222" /HighExp="Diami, H2O2, dia5, dia15, Salt, M40t45, G180, G150, G135, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S213" upshifts 637106 /Source="Nicolas_upshifts" /id="U469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig="0.997002997002997" /xcortree=1874 /SigmaFactorBS="agcaaaaaccttcattctttcatgaatttaaagtattatata agcTACTGAAaaagttttgtataAAAGGTATAATGATAAAGAAcattcgttcttgtat g" /listShort="S213, ydiO, ydiP" /GFF_Attribute="listLong" promotor_-10 637111..637130 /Source="Nicolas_upshift_promotors" /id="U469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig="0.997002997002997" /xcortree=1874 /SigmaFactorBS="agcaaaaaccttcattctttcatgaatttaaagtattatata agcTACTGAAaaagttttgtataAAAGGTATAATGATAAAGAAcattcgttcttgtat g" /listShort="S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 637191..638474 /gene="bsuMA" /locus_tag="BSU_06060" /old_locus_tag="BSU06060" /EC_number="2.1.1.37" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11751814, 12682299, 16014871, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751814, 12682299, 16014871, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-methyltransferase (cytosine-specific); prophage 3 region" /protein_id="NP_388487.1" /db_xref="EnsemblGenomes-Gn:BSU06060" /db_xref="EnsemblGenomes-Tr:CAB12425" /db_xref="GOA:O34939" /db_xref="InterPro:IPR001525" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12787" /db_xref="UniProtKB/Swiss-Prot:O34939" /translation="MTNFILNENKQLSLAIEDENIENFYIDGTDLVRKIIRRSGSGVT SRVPVLSTQDLENKNLHELYDESWLRMKNRPNTELTTESINIADLFSGCGGLSLGVWE ACRALGINPRFSFACDLNEAALSVYEKNFSPDFSLNESIEKHINGELGAPLTVEEQRI KDKVKKIDFILAGPPCQGHSDLNNHTRRKDPRNALLMRVSRVIELFQPSSVLVENVPG IIHDKSGSFKEFKNHLKTQGYYFDEIVLNAEKLGVSQARRRYFIFASKTPVSSLNQIN EFYSTNSRPISWAISDLVENVGDDIFNTASEHSLENKRRIEYLFENNLFELPNSERPD CHRLKPHSYKSVYGRMYWDRPAPTITRGFGSTGQGRFVHSLLKRTITPHEAARIQFFP DFFNFGDLRRRQYQDVIGNAVPSKLSYLLALHQLR*" gene 637191..638474 /gene="bsuMA" /locus_tag="BSU_06060" /old_locus_tag="BSU06060" CDS 638496..639665 /gene="bsuMB" /locus_tag="BSU_06070" /old_locus_tag="BSU06070" /EC_number="2.1.1.37" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11751814, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751814, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-methyltransferase (cytosine-specific); defective prophage 3" /protein_id="NP_388488.1" /db_xref="EnsemblGenomes-Gn:BSU06070" /db_xref="EnsemblGenomes-Tr:CAB12426" /db_xref="GOA:O34680" /db_xref="InterPro:IPR001525" /db_xref="InterPro:IPR018117" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR031303" /db_xref="SubtiList:BG12788" /db_xref="UniProtKB/Swiss-Prot:O34680" /translation="MKVVSLFSGIGGIELGLHQSGHTTEIFCEVDPLAKAVLSKNFPG VKIEDDINEIRELPSCDLVAAGFPCQDLSQAGGKEGIDGSRSGLVKKLFELIEKKEHA NRPPWILIENVPYMLRLNRGKAMSYLTSVLSELGYTWAYRTVDARCFGLPQRRHRVIL LASLFEDPKDVIFSQDHSEPDLDGKPSVVDHSNYYGFYWTEGLRGVGWAREAVPPIKC GSSVGIASPPAVWSPYEDIVGTINIRDAERLQGFPEDWTNITTETGKDIKEGARWRLV GNAVSVRVSKWIGENLSQPKGSISDFEGELVTKTWPSAAWGYGDKKYKVPVSKWVANT EQIAISEFLNHPLKPLSARALNGFLGRAARCTNVNYSDEFINSLERCKDRQLQKV*" gene 638496..639665 /gene="bsuMB" /locus_tag="BSU_06070" /old_locus_tag="BSU06070" downshifts 639671 /Source="Nicolas_upshifts" /id="D293" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="2.10319" /MaxDrop="7.17612" /score="34.7238204" /energy="-15.1" /TU="NA" /idTUdmin="U468" /TUdmin=0 /isTUend="TRUE" downshifts complement(639745) /Source="Nicolas_upshifts" /id="D294" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="2.48582" /MaxDrop="4.12737" /score="11.0887998" /energy="-15.6" /TU="NA" /idTUdmin="U471" /TUdmin=2 /isTUend="TRUE" CDS complement(639761..640030) /gene="ydzWc" /locus_tag="BSU_06073" /old_locus_tag="BSU06073" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphoglucomutase; C-terminal part of YdzW; defective prophage 3" /db_xref="PSEUDO:CAX52569.1" /translation="MNLASFGSVKVTTVEDYLTGIERLWKALRNSWAFHSQMFLNVFL KSDPWMCLRLSGTEPKIKFYFRVDESLAETRNPQRIEKEFMELVE*" gene complement(639761..640030) /gene="ydzWc" /locus_tag="BSU_06073" /old_locus_tag="BSU06073" /pseudo CDS complement(639987..640157) /gene="ydzWmc" /locus_tag="BSU_06074" /old_locus_tag="BSU06074" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphoglucomutase; internal part of YdzW" /translation="MSLYEALLSIEEYGYFQEGLRSLTLKGKEGAELIQQTLAAFRSE FGQLWFRQGYHC*" gene complement(639987..640157) /gene="ydzWmc" /locus_tag="BSU_06074" /old_locus_tag="BSU06074" /pseudo CDS complement(640088..640573) /gene="ydzWmb" /locus_tag="BSU_06076" /old_locus_tag="BSU06076" /EC_number="5.4.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphoglucomutase; internal part of YdzW" /translation="LIATDPDADRLGIAVKNENGEYTVLTGNQTEPLLLHYILTQIKK KGTLPSNGIVLKTIVTSELGREVATSFRVETIGVLTGFKFIARKINGYYKTGEHNFLF GYEESYGYLIGDFVRDKDAVQTDVLAVEVCAYYKKKGFHYTKLSLVLKNMATFRKACA H*" gene complement(640088..640573) /gene="ydzWmb" /locus_tag="BSU_06076" /old_locus_tag="BSU06076" /pseudo promotor_-35 640438..640441 /Source="Nicolas_upshift_promotors" /id="U470" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.997002997002997" /xcortree=3091 /SigmaFactorBS="aatcgttttaagaacgatcccattagatggaagtgttcCTTT cttttttatttgggTTAAGATATAGTGGAGCAGAagtggctcggtttgatttccggtt a" /listShort="S214" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 640456..640475 /Source="Nicolas_upshift_promotors" /id="U470" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.997002997002997" /xcortree=3091 /SigmaFactorBS="aatcgttttaagaacgatcccattagatggaagtgttcCTTT cttttttatttgggTTAAGATATAGTGGAGCAGAagtggctcggtttgatttccggtt a" /listShort="S214" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 640460 /Source="Nicolas_upshifts" /id="U470" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.997002997002997" /xcortree=3091 /SigmaFactorBS="aatcgttttaagaacgatcccattagatggaagtgttcCTTT cttttttatttgggTTAAGATATAGTGGAGCAGAagtggctcggtttgatttccggtt a" /listShort="S214" /GFF_Attribute="listLong" S_feature 640463..640867 /Source="Nicolas_S_feature" /locus_tag="new_658495_658899" /HighExp="Cold, LoTm, C30, T0.30H, HPh, Gly, S0, LPh, UNK1, T1.0H" /AntisenseName="ydzW" /AntisenseCor="0.298083403528066" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S214" CDS complement(640583..640726) /gene="ydzW" /locus_tag="BSU_06077" /old_locus_tag="BSU06077" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphomannomutase; internal part of YdzW" /db_xref="PSEUDO:CAX52572.1" /translation="MALAAMNYKHVAVGKEQEQPALCFPLSPVQMLKNMPRLSWPSGK AAN*" gene complement(640583..640726) /gene="ydzW" /locus_tag="BSU_06077" /old_locus_tag="BSU06077" /pseudo CDS complement(640781..640978) /gene="ydzW" /locus_tag="BSU_06078" /old_locus_tag="BSU06078" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphoglucomutase; internal part of YdzW" /translation="FAVRHLHGFAGIVVTASHNPPEYNGYKVYGPDGGQLPPSKGPDQ NIAQRWTRHTLNYFRKLKYLR*" gene complement(640781..640978) /gene="ydzW" /locus_tag="BSU_06078" /old_locus_tag="BSU06078" /pseudo CDS complement(640936..641097) /gene="ydzWma" /locus_tag="BSU_06079" /old_locus_tag="BSU06079" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphomannomutase; internal part of YdzW" /translation="DIYTLRKVSAGLAAFIMEAARTLASSAYVFESLRPTTVLSLQYV TFMVLPVLL*" gene complement(640936..641097) /gene="ydzWma" /locus_tag="BSU_06079" /old_locus_tag="BSU06079" /pseudo CDS complement(641082..641189) /gene="ydzWn" /locus_tag="BSU_06083" /old_locus_tag="BSU06083" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphomannomutase; N-terminal part of YdzW; defective prophage 3" /translation="MRKTWKMLFIRNLGYGTGGMRGEIGAGTNRMTSIR*" gene complement(641082..641189) /gene="ydzWn" /locus_tag="BSU_06083" /old_locus_tag="BSU06083" /pseudo S_feature complement(641190..641309) /Source="Nicolas_S_feature" /locus_tag="new_659222_659341_c" /HighExp="LoTm, T4.0H, BC, T5.0H, M9-stat, T3.30H, S2, T3.0H, Sw, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S215" promotor_-10 complement(641300..641319) /Source="Nicolas_upshift_promotors" /id="U471" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.321678321678322" /psig="0.993006993006993" /xcortree=2932 /SigmaFactorBS="caagagcactcgatttatgtcagaaagtcgtCGTTcgaaaac ctctagacTATATTATAATGAACAATAAtgttattttattgtaggtcaatcataggct g" /listShort="S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(641309) /Source="Nicolas_upshifts" /id="U471" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.321678321678322" /psig="0.993006993006993" /xcortree=2932 /SigmaFactorBS="caagagcactcgatttatgtcagaaagtcgtCGTTcgaaaac ctctagacTATATTATAATGAACAATAAtgttattttattgtaggtcaatcataggct g" /listShort="S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /GFF_Attribute="listLong" S_feature complement(641311..641526) /Source="Nicolas_S_feature" /locus_tag="new_659343_659558_c" /HighExp="LBGstat, T0.30H, M9-stat, T1.0H, T1.30H, Lbtran, T2.0H, LBGtran, T2.30H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.11296" /TUshortSig="SigA" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S216" promotor_-35 complement(641335..641338) /Source="Nicolas_upshift_promotors" /id="U471" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.321678321678322" /psig="0.993006993006993" /xcortree=2932 /SigmaFactorBS="caagagcactcgatttatgtcagaaagtcgtCGTTcgaaaac ctctagacTATATTATAATGAACAATAAtgttattttattgtaggtcaatcataggct g" /listShort="S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 641503..641509 /Source="Nicolas_upshift_promotors" /id="U473" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig=1 /xcortree=2344 /SigmaFactorBS="taccaattcgatatttgaattggtctctcaaacaaTTCCATC ctctttatttatTATGATACAATTATATTAATtagaaaatacatacatattagcttgt g" /listShort="ydiR, ydiS, ydjA, S217, S218, ydjB, S219, ydjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(641512..641531) /Source="Nicolas_upshift_promotors" /id="U472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.458541458541459" /psig="0.977022977022977" /xcortree=3186 /SigmaFactorBS="tttacccccataaaatcacacaagctaatatgtatgtATTTt ctaattaatataaTTGTATCATAATAAATAAAGaggatggaattgtttgagagaccaa t" /listShort="S216, S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /listLong="ydzW" /label="promotor_-10" promotor_-10 641522..641541 /Source="Nicolas_upshift_promotors" /id="U473" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig=1 /xcortree=2344 /SigmaFactorBS="taccaattcgatatttgaattggtctctcaaacaaTTCCATC ctctttatttatTATGATACAATTATATTAATtagaaaatacatacatattagcttgt g" /listShort="ydiR, ydiS, ydjA, S217, S218, ydjB, S219, ydjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(641526) /Source="Nicolas_upshifts" /id="U472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.458541458541459" /psig="0.977022977022977" /xcortree=3186 /SigmaFactorBS="tttacccccataaaatcacacaagctaatatgtatgtATTTt ctaattaatataaTTGTATCATAATAAATAAAGaggatggaattgtttgagagaccaa t" /listShort="S216, S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /listLong="ydzW" upshifts 641528 /Source="Nicolas_upshifts" /id="U473" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig=1 /xcortree=2344 /SigmaFactorBS="taccaattcgatatttgaattggtctctcaaacaaTTCCATC ctctttatttatTATGATACAATTATATTAATtagaaaatacatacatattagcttgt g" /listShort="ydiR, ydiS, ydjA, S217, S218, ydjB, S219, ydjC" /GFF_Attribute="listLong" promotor_-35 complement(641546..641549) /Source="Nicolas_upshift_promotors" /id="U472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.458541458541459" /psig="0.977022977022977" /xcortree=3186 /SigmaFactorBS="tttacccccataaaatcacacaagctaatatgtatgtATTTt ctaattaatataaTTGTATCATAATAAATAAAGaggatggaattgtttgagagaccaa t" /listShort="S216, S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /listLong="ydzW" /label="promotor_-35" CDS 641591..642532 /gene="bsuRA" /locus_tag="BSU_06090" /old_locus_tag="BSU06090" /EC_number="3.1.21.4" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11751814, 15728999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751814, 15728999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type-2 restriction enzyme BsuMI component BsuRA (YdiR); prophage region 3" /protein_id="NP_388490.1" /db_xref="EnsemblGenomes-Gn:BSU06090" /db_xref="EnsemblGenomes-Tr:CAB12428" /db_xref="GOA:O35025" /db_xref="SubtiList:BG12790" /db_xref="UniProtKB/Swiss-Prot:O35025" /translation="MTFIKRLEDAYETLLGNYPAGVSSTSTSKYNEIRKIVSEAFLIG ENEVYVTGTSRRISNLDTRFAQGNQRNKHTRMAVAFISIPSVDDSELDELIIRTRNSA ITTSSKFCNGEERGTIFDGILLFLVFEGETKVYPLAFLVFENDFELKEKAEELIPGIE LKEYPRANQSPAQENNKSAKNEDEESAKSYVVFLDIEEDGSIVEFVEDKDKTYRIGDM IWTASHTNGSSAITRRLEVIEVVENLVVCKIKHKYNEPVDKNSLLKFVNIEQDLISFL DLHPNVQNGSEGFVSGDIVDENATTSSDDLPEDFENN*" gene 641591..642532 /gene="bsuRA" /locus_tag="BSU_06090" /old_locus_tag="BSU06090" CDS 642564..643595 /gene="bsuRB" /locus_tag="BSU_06100" /old_locus_tag="BSU06100" /EC_number="3.1.21.4" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11751814" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type-2 restriction enzyme BsuMI component BsuRB (YdiS); prophage region 3" /protein_id="NP_388491.1" /db_xref="EnsemblGenomes-Gn:BSU06100" /db_xref="EnsemblGenomes-Tr:CAB12429" /db_xref="GOA:O34885" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12791" /db_xref="UniProtKB/Swiss-Prot:O34885" /translation="MEISKQTSDLLLSLEKKKGTLPKFSVLRSIPRNRIIYGAPGTGK SNYLEREVGKIFGDNPYVFTRVTFFPGYTYGQFIGAYKPVPIYKKLSGEEEIFSSNFR DKMENFEPMIDYQFVPGPFIDVLIKALKNRYTNFILIIEEINRANAASVFGDIFQLLD RNKNGESDYPVTFGPDIMNYLARNGIKDEMIKLPSNFFIWATMNNADQGVLPLDTAFK RRWSFEYLELEKYRKAVDSWKLSLRYKGHNKVIMWNDFRDIINKRLKGKVPEDKLLGP FFLKESELWNQNVFKNKLLYYLKEDVFKHNPTIDFLNASTFSELIEKYDGSDNIFTFD IDDSSFVSD*" gene 642564..643595 /gene="bsuRB" /locus_tag="BSU_06100" /old_locus_tag="BSU06100" CDS 643598..644995 /gene="bsuRC" /locus_tag="BSU_06110" /old_locus_tag="BSU06110" /EC_number="3.1.21.4" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11751814" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type-2 restriction enzyme BsuMI component BsuRC (YdjA); prophage region 3" /protein_id="NP_388492.1" /db_xref="EnsemblGenomes-Gn:BSU06110" /db_xref="EnsemblGenomes-Tr:CAB12430" /db_xref="GOA:O34303" /db_xref="InterPro:IPR018579" /db_xref="SubtiList:BG12792" /db_xref="UniProtKB/Swiss-Prot:O34303" /translation="MDKSSKFFFEDQKYNKERIVRVLGGNLALLKSKGILYEDSSGDL IFNYVGVISNGRNVIFILPKYCNRHLDEHSKRTLFNKLLKIFKKYSGLNKSRESDYFV SELDSDEVSDFMIADYLLNDFSLNGYYQKKFTEYEIDGEGIIDWSKTVNEITPVFSKG VPYYFSTYNEVVQKDEYHLIVKIHKWALSKYFNDFGVILGFTGLEFDKSCDGMKILDY ADFFGSVINKEIVNTYVDRDVKLLKALKTAIDREENQFSKRPTLSLYGTKYFHRVWEE VCKTVFSHVNEYVKKISRPNWINFTDIEVNKEKKTLEPDIIKAFEYRSKEYFLILDAK YYNINFDGKKLEGNPGVEDITKQLLYDKALEKLSRGKTKHNAFLFPSSNSTNTFKVFG SVDFDFLDIAAVTLVYISAEQVYNLYLENKTFSTDDLFKFVSEINKSKKRHSVITSTL YGNMFLFTKRLSDKN*" gene 643598..644995 /gene="bsuRC" /locus_tag="BSU_06110" /old_locus_tag="BSU06110" S_feature 644996..645192 /Source="Nicolas_S_feature" /locus_tag="new_663028_663224" /HighExp="Lbtran, C90, M40t45, HPh, M0t45, LBGtran, aero, Lbstat, BI, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S217" downshifts 645149 /Source="Nicolas_upshifts" /id="D295" /incds=0 /nref=3 /ntot=131 /MaxReadThrough="5.36465" /MaxDrop="3.0162" /score="7.16368756" /energy="-18.1" /TU="U473" /idTUdmin="U473" /TUdmin="-1364" /isTUend="FALSE" downshifts 645211 /Source="Nicolas_upshifts" /id="D296" /incds=0 /nref=5 /ntot=69 /MaxReadThrough="4.58628" /MaxDrop="3.49698" /score="7.16368756" /energy="-18.1" /TU="U473" /idTUdmin="U473" /TUdmin="-1302" /isTUend="FALSE" S_feature 645256..645568 /Source="Nicolas_S_feature" /locus_tag="new_663288_663600" /HighExp="dia15, Diami, H2O2, Paraq, dia5, LBGstat, G180, Oxctl, LBGexp, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S218" CDS 645569..645904 /gene="ydjB" /locus_tag="BSU_06120" /old_locus_tag="BSU06120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; prophage region 3" /protein_id="NP_388493.1" /db_xref="EnsemblGenomes-Gn:BSU06120" /db_xref="EnsemblGenomes-Tr:CAB12431" /db_xref="SubtiList:BG12793" /db_xref="UniProtKB/Swiss-Prot:O34778" /translation="MLNIKSDRIMTSDPQKFTVDGVRFFQQYLNKIRPDAMEIDNLII NSDIIKEDLIVHVSKMIDRLALYDLHRKRSIDKHFSAAFTVDINDREEFYSANIADVS IDLNESSGV*" gene 645569..645904 /gene="ydjB" /locus_tag="BSU_06120" /old_locus_tag="BSU06120" S_feature 645905..646286 /Source="Nicolas_S_feature" /locus_tag="new_663937_664318" /HighExp="H2O2, dia15, G135, Paraq, G180, G150, Diami, Oxctl, LBGexp, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S219" CDS 646287..646637 /gene="ydjC" /locus_tag="BSU_06130" /old_locus_tag="BSU06130" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388494.1" /db_xref="EnsemblGenomes-Gn:BSU06130" /db_xref="EnsemblGenomes-Tr:CAB12432" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12794" /db_xref="UniProtKB/Swiss-Prot:O34715" /translation="MVSIFYANRLSYSIWNTIPGKYIREELEQNGVTYNELIKYWDIT DPSQALPKVNKDNVLLISAKHDQYIDLKDADYLWESWGRPTRYVYNCGHSGIVLCRKK LANDTLSFIREKLV*" gene 646287..646637 /gene="ydjC" /locus_tag="BSU_06130" /old_locus_tag="BSU06130" downshifts 646513 /Source="Nicolas_upshifts" /id="D297" /incds=1 /nref=1 /ntot=71 /MaxReadThrough="1.89703" /MaxDrop="2.58458" /score="-4.72838456" /energy="-13.9" /TU="NA" /idTUdmin="U473" /TUdmin=0 /isTUend="TRUE" CDS complement(646743..649232) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" gene complement(646743..649232) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" downshifts complement(646765) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(649246..649265) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(649272) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" promotor_-35 complement(649279..649286) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 649335..649336 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 649351..649433 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 649351 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" promotor_-10 649352..649371 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 649434..650495 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" gene 649434..650495 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" CDS 650569..651960 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" gene 650569..651960 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" promotor_-35 651987..651994 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 652008..652027 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 652013 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" CDS 652055..653017 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" gene 652055..653017 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" downshifts 653002 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" promotor_-35 653142..653151 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 653158 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" promotor_-10 653164..653179 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 653213..653896 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" gene 653213..653896 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" S_feature 653897..653961 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 653962..654987 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" gene 653962..654987 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" CDS 654987..655751 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" gene 654987..655751 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" CDS 655782..656753 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" gene 655782..656753 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" downshifts 656743 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" downshifts 656787 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" CDS complement(656800..657825) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" gene complement(656800..657825) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" promotor_-10 complement(657857..657876) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657875) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" promotor_-35 complement(657890..657896) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 658085..658092 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 658105 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" S_feature 658107..658409 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 658107..658126 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 658410..659831 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" gene 658410..659831 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" downshifts 659823 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" downshifts complement(659879) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" CDS complement(659879..660919) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" gene complement(659879..660919) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" promotor_-35 660459..660468 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 660482..660501 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 660483..661018 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 660483 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" S_feature complement(660920..661214) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 661019..661038 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 661020..661317 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 661020 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" misc_feature complement(661209..661223) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(661214) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" promotor_-35 661297 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 661316..661335 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 661319 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" CDS 661358..661729 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" gene 661358..661729 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" downshifts 661715 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" CDS 661795..662841 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" gene 661795..662841 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" downshifts 662815 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" CDS complement(662875..663033) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" gene complement(662875..663033) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" downshifts complement(662891) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" S_feature complement(663090..663222) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(663133) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" CDS complement(663223..663432) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" gene complement(663223..663432) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" promotor_-10 complement(663465..663484) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(663476) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" promotor_-35 complement(663501) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(663515..664330) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" gene complement(663515..664330) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" promotor_-35 664157..664166 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 664179..664198 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 664179 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(664343..665332) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" gene complement(664343..665332) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" promotor_-10 complement(665197..665215) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(665205) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" promotor_-35 complement(665231..665236) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(665354..665369) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(665375) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" promotor_-35 complement(665381..665390) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(665430..666971) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" gene complement(665430..666971) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" downshifts complement(665443) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(667002..667021) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(667016) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" promotor_-35 complement(667035..667044) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(667123..668532) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" gene complement(667123..668532) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" downshifts complement(667137) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" CDS complement(668570..668857) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" gene complement(668570..668857) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" misc_feature complement(668573..668592) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(668587) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" promotor_-35 668863..668870 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 668886..668905 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 668887 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" CDS 668930..669802 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" gene 668930..669802 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" downshifts 669767 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" downshifts complement(670042) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" misc_feature 670096..670115 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 670106 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" CDS 670152..671114 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" gene 670152..671114 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" CDS 671114..672310 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" gene 671114..672310 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" CDS 672332..674545 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" gene 672332..674545 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" promotor_-35 674540..674547 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 674562..674581 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 674578..674707 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 674578 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" CDS 674708..676249 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" gene 674708..676249 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" downshifts 676235 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" promotor_-35 676356..676360 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 676376..676395 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 676386 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" misc_RNA 676393..676495 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" gene 676393..676495 /gene="gswC" /locus_tag="BSU_misc_RNA_9" downshifts 676521 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" CDS 676630..677952 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" gene 676630..677952 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" downshifts 677930 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" downshifts 677973 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" promotor_-35 678002..678011 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 678022..678162 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 678022 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" promotor_-10 678024..678039 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 678163..678966 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" gene 678163..678966 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" downshifts 678951 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" promotor_-35 679034..679041 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 679055..679074 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 679061..679124 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 679061 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" CDS 679125..679292 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" gene 679125..679292 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" downshifts 679299 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" promotor_-35 679343..679349 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 679364..679382 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 679367..679453 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 679367 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" promotor_-35 679432..679439 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 679453..679472 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 679455 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" CDS 679506..680060 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" gene 679506..680060 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" CDS 680060..680257 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" gene 680060..680257 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" downshifts 680247 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" promotor_-35 680303..680310 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 680325..680344 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 680327 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" misc_RNA 680337..680439 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" gene 680337..680439 /gene="gswD" /locus_tag="BSU_misc_RNA_10" S_feature 680440..680579 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 680580..681068 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" gene 680580..681068 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" CDS 681061..682203 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" gene 681061..682203 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" CDS 682200..683495 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" gene 682200..683495 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" promotor_-10 complement(682505..682524) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(682526) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(682539..682546) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 683569..684294 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" gene 683569..684294 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" CDS 684287..684541 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" gene 684287..684541 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" CDS 684538..685221 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" gene 684538..685221 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" CDS 685205..687433 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" gene 685205..687433 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" downshifts complement(685453) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" CDS 687409..688839 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" gene 687409..688839 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" S_feature 688840..688940 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 688941..689981 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" gene 688941..689981 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" CDS 689978..690565 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" gene 689978..690565 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" misc_feature 689988..690002 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 689997 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" promotor_-10 complement(690264..690282) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(690271) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(690298..690303) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 690562..692100 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" gene 690562..692100 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" CDS 692116..693384 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" gene 692116..693384 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" downshifts 693369 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" CDS complement(693424..693843) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" gene complement(693424..693843) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" misc_feature complement(693913..693932) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(693922) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" CDS 693987..695261 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" gene 693987..695261 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" downshifts 695210 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" CDS complement(695276..695503) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" gene complement(695276..695503) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" downshifts complement(695287) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" S_feature complement(695504..695924) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 695571..695576 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 695587 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" promotor_-10 695590..695609 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 695632..697374 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" gene 695632..697374 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" promotor_-10 complement(695909..695920) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(695924) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" promotor_-35 complement(695934..695940) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 695955 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" promotor_-35 697348..697354 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 697366 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" promotor_-10 697367..697386 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 697401..698396 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" gene 697401..698396 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" CDS 698399..698713 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" gene 698399..698713 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" downshifts 698576 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" downshifts 698718 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" CDS complement(698748..700325) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" gene complement(698748..700325) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" downshifts complement(698762) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(700339..700358) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(700358) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" promotor_-35 complement(700373..700379) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 700522..700525 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 700539 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" promotor_-10 700542..700561 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 700590..701276 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" gene 700590..701276 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" CDS 701338..703557 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " gene 701338..703557 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" CDS 703581..705587 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" gene 703581..705587 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" CDS 705603..706793 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" gene 705603..706793 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" misc_feature complement(705798..705802) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(705802) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 706830..706849 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 706838..706954 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 706838 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" downshifts complement(706902) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" CDS 706955..707965 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" gene 706955..707965 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" promotor_no_box complement(706972..707072) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(707012) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 707948 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" S_feature 707992..708796 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(708003..708701) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" gene complement(708003..708701) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" downshifts complement(708024) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(708721..708739) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(708742) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" promotor_-35 complement(708755..708760) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(708808..710286) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" gene complement(708808..710286) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" downshifts complement(708822) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" upshifts complement(709674) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" misc_feature complement(709677..709690) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(710287..710417) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(710408..710426) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(710417) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" promotor_-35 complement(710441..710447) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 710548..710551 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 710566..710699 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 710566 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" promotor_-10 710568..710587 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 710700..710990 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" gene 710700..710990 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" CDS 711006..712463 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" gene 711006..712463 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" CDS 712477..713907 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" gene 712477..713907 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" downshifts 713888 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" CDS complement(713922..714791) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" gene complement(713922..714791) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" downshifts complement(713964) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" promotor_-35 714581..714586 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 714602..714620 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 714614 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" S_feature complement(714792..714866) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 714844..714851 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(714860..714879) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 714866 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" promotor_-10 714867..714886 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(714873) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" promotor_-35 complement(714894..714901) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 714923..718081 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" gene 714923..718081 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" downshifts 718068 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" promotor_-35 718320..718323 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 718338..718357 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 718346 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" CDS 718404..719315 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" gene 718404..719315 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" S_feature 719316..719570 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 719571..720950 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" gene 719571..720950 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" S_feature 720951..721543 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" CDS complement(720963..721865) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1779754, 1762151; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase / invertase; HGT island" /protein_id="NP_388556.1" /db_xref="EnsemblGenomes-Gn:BSU06740" /db_xref="EnsemblGenomes-Tr:CAB12494" /db_xref="GOA:O34574" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="SubtiList:BG12827" /db_xref="UniProtKB/Swiss-Prot:O34574" /translation="MYNEGVTSPSQLARKKNATDKWHGSSIRKILENPHYTGTLQQCR EYRPSVTSKRRRSVNLENQIIIEKSHEPIIPLEDFLIVQEILITRKRRRPQAEVHLFT NTAVCKDCRRSMHFKKNRKGYVCGSYNKHGLKACSDHYVSEIDLTDKVITNLNKIYLK FSKENYFKELSEKALKYKEKIESKIIEINEKLNDKKRDKSNLVISLANGVISKEDYQL AINITNEDISNFETTLHQLSKDLEFQKIEKEIIDFKKSLDKFMKEGTLTPEMLHLLVD EIEVHANGTIEINYRFREPTVPSA*" gene complement(720963..721865) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" downshifts 721500 /Source="Nicolas_upshifts" /id="D334" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="4.70474" /MaxDrop="2.82299" /score="-8.81916201" /energy="-8.8" /TU="U518" /idTUdmin="U516" /TUdmin=3322 /isTUend="FALSE" S_feature 721545..721845 /Source="Nicolas_S_feature" /locus_tag="new_739577_739877" /HighExp="H2O2, Cold, G180, G135, G150, Paraq, Oxctl, C30, LPh, LBGexp" /AntisenseName="yefB" /AntisenseCor="0.202214664414261" /AntisenseRegPval="-3.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S241" CDS 721846..722181 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative resolvase; HGT island" /protein_id="NP_388557.2" /db_xref="EnsemblGenomes-Gn:BSU06750" /db_xref="EnsemblGenomes-Tr:CAB12495" /db_xref="GOA:O35034" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG12828" /db_xref="UniProtKB/Swiss-Prot:O35034" /translation="MTPSLYNPLAIASKPFPAIYSEKILIFTIFSAFAEFERDMIVER TQEGKMLAKQNPDFREGRPKKFTKQQINHALTLLENHSYKQVEDMTGISVSTLVRAKK KKAAEAING*" gene 721846..722181 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" S_feature 722182..722255 /Source="Nicolas_S_feature" /locus_tag="new_740214_740287" /HighExp="G180, H2O2, G150, Cold, G135, Paraq, Oxctl, C30, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S242" CDS 722256..724895 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative restriction type II methylase; HGT island" /protein_id="NP_388558.1" /db_xref="EnsemblGenomes-Gn:BSU06760" /db_xref="EnsemblGenomes-Tr:CAB12496" /db_xref="GOA:O31504" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12818" /db_xref="UniProtKB/Swiss-Prot:O31504" /translation="MALIDLEDKIAEIVNREDHSDFLYELLGVYDVPRATITRLKKGN QNLTKRVGEVHLKNKVWFKEAKKGKLFDALIDIEQQVEYLSAKPRYLLVTDYDGVLAK DTKTLEALDVKFEELPQYFDFFLAWKGIEKVEFEKENPADIKAAERFARIYDVLRKEN NIIETNRGLDLFLIRLLFCFFAEDTDIFKRNSFTNLIKTLTEEDGSNLNKLFADLFIV LDKNERDDVPSYLKEFPYVNGQLFTEPHTELEFSAKSRKLIIECGELLNWAKINPDIF GSMIQAVASEESRSYLGMHYTSVPNIMKVIKPLFLDKLNQSFLDAYDDYTKLENLLTR IGKIKFFDPACGSGNFLIITYKELRRMEINIIKRLQELLGEYLYVPSVTLSQFYGIEI EDFAHDVAKLSLWIAEHQMNEELKNEVHNAVRPTLPLHTAGDIRCANAIRVEWTEVCP AQGSEEVYVFGNPPYLGSKKQNKEHKSDMLSIFGKVKNGKMLDYISAWFYFGAKYAST TNAKVAFVSTNSVTQGEQVSILWNELFKFGIQINFAYKSFKWANNAKNNAAVIVVIVG FGPLDTKVNKYLFVDETKKLVSNISPYLTDGENILVSSRTKPISDLPKLHFGNMPNDG GGLLFTITEYTDAINKYPELVPYFKKFIGSVEFINGGLRYCLWLNEAKYEKIKSNPLI QERISISKNHREKSTDKGTNKLALTPWKFRDTHETTNYSIVVPSVSSENRFYIPMGLA GADTILSNLIYVIYDAEIYLLGILMSRMHMTWVKAVAGRLKTDYRYSAGLCYNTFPIP ELSTRRKNEIEEAILEILDLREEQGGTLAELYNPSTMPIELKVAHEKLDGIVERAYRQ KQFESDEERLEVLLKLYQEMTER*" gene 722256..724895 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" CDS 724907..726706 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA helicase / endonuclease; HGT island" /protein_id="NP_388559.2" /db_xref="EnsemblGenomes-Gn:BSU06770" /db_xref="EnsemblGenomes-Tr:CAB12497" /db_xref="GOA:O34469" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12819" /db_xref="UniProtKB/Swiss-Prot:O34469" /translation="MENIIEINYNQTGKSKKTNEYGMREMQARAFEKRNSQYLLVKAP PASGKSRALMFIGLDKLINQGLRKVIVAVPERSIGSSFKNTDLKSYGFFENWKVDPRN NLTVGGDNSKVKSFVRFMESDDQVLICTHSTLRFAFEKIDDKAFDNCLLAIDEFHHVS ADVNSRLGELLRSIIHNSSAHIVAMTGSYFRGDSVPILLPEDEELFDKVTYSYYEQLD GYEYLKGFGIGYHFYQGQYTSAINEVLDTNKKTIVHIPNVNSGESTKDKYDEVGKILD MIGEVEYQDDDTGIIYVKRHSDGKTLKIADLVDDQVGRENVVAYLRNIEALDDLDIII ALGMAKEGFDWPFCEHTLTVGYRGSLTEIVQIIGRCTRDSYNKTYAQFTNLIAMPDAK DEVVTYTVNTMLKAISASLLMEQVLTPDFKFKRRRNESEKSSTTGELFVKGLKEPSTE NVKKIIENDINDLKAKIMQDSQVQKTFSGEVDPKVLNKVLIPKVIQKVYPNLSDEEIE EVRQHVVLDTVMKGAKSEVVGSKEFIRMADKFINIEDLDINLIDSINPFQKAFEVLSK ELNSPVLKLIQETIDAKRINFDEDELVFIWPKV*" gene 724907..726706 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" promotor_-10 complement(725147..725162) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(725162) /Source="Nicolas_upshifts" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(725174..725183) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 726707..726818 /Source="Nicolas_S_feature" /locus_tag="new_744739_744850" /HighExp="Cold, G180, G135, G150, H2O2, Paraq, HPh, LPh, Oxctl, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S243" CDS 726819..727967 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388560.2" /db_xref="EnsemblGenomes-Gn:BSU06780" /db_xref="EnsemblGenomes-Tr:CAB12498" /db_xref="InterPro:IPR018306" /db_xref="SubtiList:BG12820" /db_xref="UniProtKB/Swiss-Prot:O34352" /translation="MASNRYHSINEIMESQLFYQITTPPKKTQKAQYDPEVEKFLEII EFVKENGREPQKVPTDLTERSLASRLIGIRKDPDRMEYLKEYDEIGLLEVRSKELTIP KISSIDDILKSGLSALLGDNLNNDITRSIFDTSSLQKVTTMPEYVAKRKKIKDFGKFE ELFKKCHKEITEGKRKILTFKNEQDIQSNSFYILKGVLLYVEDVGERKKAKGKTNARL RCIFENGTESDMLLRSLSAELYKHGRRVTDNEDTLLDNVREDDVSTGFIYVLKSLSTD PQISSIKNLYKIGFTTGSVENRIRNAENQSTYLYAPVEIVTTYQVFNMNASKFETAIH HALANNNLDVSILGANGKMLVPKEWFVVTLEDLQAVIDEIVMMVHLYD*" gene 726819..727967 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" S_feature 727968..729157 /Source="Nicolas_S_feature" /locus_tag="new_746000_747189" /HighExp="Cold, G135, H2O2, G180, G150, LPh, C30, HPh, BMM, Paraq" /AntisenseName="yeeD" /AntisenseCor="-0.41772847620445203" /AntisenseRegPval="-12.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S244" CDS complement(728229..728534) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388561.1" /db_xref="EnsemblGenomes-Gn:BSU06790" /db_xref="EnsemblGenomes-Tr:CAB12499" /db_xref="SubtiList:BG12821" /db_xref="UniProtKB/Swiss-Prot:O34950" /translation="MTVRKELIKQINLTITVIKTINQKNPTPMVKNILKRYEEAKEFI LQSSDGKFEEDLSKVRNKLDTLTRAYLESANDYMNPMLKEMHKTEKLLKEYDETTQS* " gene complement(728229..728534) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" CDS complement(728601..728807) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="hypothetical protein; HGT island" /protein_id="NP_388562.1" /db_xref="EnsemblGenomes-Gn:BSU06800" /db_xref="EnsemblGenomes-Tr:CAB12500" /db_xref="GOA:O31505" /db_xref="InterPro:IPR000290" /db_xref="InterPro:IPR035900" /db_xref="SubtiList:BG12872" /db_xref="UniProtKB/Swiss-Prot:O31505" /translation="MDKLTKEELIFLVKELMNPTLDDEKVSEYLDLLEKNVPYPAPSD LIFWSNEDYTAEQVVKIALNYKDE*" gene complement(728601..728807) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" CDS complement(729047..729502) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="YP_003097692.1" /db_xref="EnsemblGenomes-Gn:BSU06811" /db_xref="EnsemblGenomes-Tr:CAX52579" /db_xref="InterPro:IPR006728" /db_xref="InterPro:IPR036170" /db_xref="UniProtKB/Swiss-Prot:C0H3X4" /translation="MQDLYQLIGEKLNDIIPGEWTKIYLYAEVLDDSTMVLFHFRTPE NNQIIYSQDIPSHYNVSKDIFKTLLRELRELFEELRTEHRNNNDDVWTNLTLTLDRSG EFQLDYNYDDILASELDGYERIAIWEYKNLGILPEDEDDKEFVISYLGL*" gene complement(729047..729502) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" downshifts complement(729060) /Source="Nicolas_upshifts" /id="D335" /incds=0 /nref=41 /ntot=213 /MaxReadThrough="4.42275" /MaxDrop="5.23695" /score="10.2582155" /energy="-11.7" /TU="U520,U521" /idTUdmin="U520" /TUdmin="-529" /isTUend="FALSE" CDS complement(729522..731531) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein; HGT island" /protein_id="NP_388563.2" /db_xref="EnsemblGenomes-Gn:BSU06812" /db_xref="EnsemblGenomes-Tr:CAB12501" /db_xref="GOA:O31506" /db_xref="InterPro:IPR006829" /db_xref="SubtiList:BG12822" /db_xref="UniProtKB/Swiss-Prot:O31506" /translation="MKVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDSE FSGKGASNIKAFYHDHVGVADQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEH ELANANKKSKSIMSEQKKAMKDILNDIDDILPLDLFSTETFKDELADANDKRKKTLEK LDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKK GDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQ RYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAMAHPIKT YEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTAAKVT TKVKTAASKSATAQKAITVSKQTVDHIKQKVNTGIEVSKKHVKTKLNQIGDLTLADIL PYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPHVPPVTV KYGEHFARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQTN AGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGKWYEMEQEWAKALSKK PPKKVAVQIEPVYSGDSLRPSYFDVTYKIGSRKEISVSIKNQPGG*" gene complement(729522..731531) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" promotor_-10 complement(729889..729908) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(729896) /Source="Nicolas_upshifts" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" promotor_-35 complement(729921..729926) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(731558..731577) /Source="Nicolas_upshift_promotors" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(731568) /Source="Nicolas_upshifts" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" CDS 731743..732765 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage receptor protein" /protein_id="NP_388564.2" /db_xref="EnsemblGenomes-Gn:BSU06820" /db_xref="EnsemblGenomes-Tr:CAB12502" /db_xref="GOA:O31507" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12823" /db_xref="UniProtKB/Swiss-Prot:O31507" /translation="MTKKRITFGLLVLMVCVILFVLYVQLRNKDSIPVQSSAIHPEED RIFFIYSNPFIKESVLLSTSTGERFNRRTFKVADVPYIQTKSYASTDLVLLAEHEPFY YTLEKDVIKEHPLSDPFAFWYEGKDVTIEAYNVDTTGNEIHINDRKTKKEYTLTLPPL VTMGASDENFIYIIQSMSIYVIDRKTEEMIETLSLASYADQFADSEEFIVASSDHKLT VIEKGTWKTTYIAYPEDLEYADTVYYDKESGSFYVAYEDKEGGANLLEYGEDFSIHTY SLKFPYMEAKFKGNLLYIVAQEEHKKGIGGYVGVFDIHSKEMLYQFDLPEEQVKVQDF VVVDNK*" gene 731743..732765 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" promotor_-35 732865..732872 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-35" promotor_-10 732886..732905 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-10" upshifts 732887 /Source="Nicolas_upshifts" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" CDS 732927..734057 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388565.2" /db_xref="EnsemblGenomes-Gn:BSU06830" /db_xref="EnsemblGenomes-Tr:CAB12503" /db_xref="GOA:Q59HN8" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG11031" /db_xref="UniProtKB/Swiss-Prot:Q59HN8" /translation="MSQAIPSSRVGVKINEWYKMIRQFSVPDAEILKAEVEQDIQQME EDQDLLIYYSLMCFRHQLMLDYLEPGKTYGNRPTVTELLETIETPQKKLTGLLKYYSL FFRGMYEFDQKEYVEAIGYYREAEKELPFVSDDIEKAEFHFKVAEAYYHMKQTHVSMY HILQALDIYQNHPLYSIRTIQSLFVIAGNYDDFKHYDKALPHLEAALELAMDIQNDRF IAISLLNIANSYDRSGDDQMAVEHFQKAAKVSREKVPDLLPKVLFGLSWTLCKAGQTQ KAFQFIEEGLDHITARSHKFYKELFLFLQAVYKETVDERKIHDLLSYFEKKNLHAYIE ACARSAAAVFESSCHFEQAAAFYRKVLKAQEDILKGECLYAY*" gene 732927..734057 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" CDS 734047..734220 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type r: regulator" /codon_start=1 /transl_table=11 /product="hexapeptide (TDRNTT) inhibitor of regulatory cascade" /protein_id="YP_003097693.1" /db_xref="EnsemblGenomes-Gn:BSU06839" /db_xref="EnsemblGenomes-Tr:CAX52580" /db_xref="GOA:Q59HN7" /db_xref="UniProtKB/Swiss-Prot:Q59HN7" /translation="MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDH SPYKLSDQKKALS*" gene 734047..734220 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" downshifts 734175 /Source="Nicolas_upshifts" /id="D336" /incds=0 /nref=3 /ntot=66 /MaxReadThrough="5.5891" /MaxDrop="2.9063" /score="14.5772672" /energy="-7.6" /TU="U522" /idTUdmin="U522" /TUdmin="-901" /isTUend="FALSE" S_feature 734221..734325 /Source="Nicolas_S_feature" /locus_tag="new_752253_752357" /HighExp="S2, G/S, T2.30H, GM 150, T3.0H, T2.0H, S1, T-4.40H, T-2.40H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S245" promotor_-35 734292..734299 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 734314..734333 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 734327 /Source="Nicolas_upshifts" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" CDS 734380..735099 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA integrase or transcriptional regulator" /protein_id="NP_388566.3" /db_xref="EnsemblGenomes-Gn:BSU06840" /db_xref="EnsemblGenomes-Tr:CAB12504" /db_xref="GOA:O31509" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026562" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG12824" /db_xref="UniProtKB/Swiss-Prot:O31509" /translation="MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESN QALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNN VNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRD ILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKL IDALEDLEDVQQVYHNVDLGE*" gene 734380..735099 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" downshifts complement(734382) /Source="Nicolas_upshifts" /id="D337" /incds=0 /nref=3 /ntot=70 /MaxReadThrough="1.42969" /MaxDrop="3.99424" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-5851" /isTUend="FALSE" promotor_-35 734957..734964 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 734978..734997 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 734988 /Source="Nicolas_upshifts" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" downshifts 735081 /Source="Nicolas_upshifts" /id="D338" /incds=0 /nref=223 /ntot=271 /MaxReadThrough="4.94236" /MaxDrop="5.19148" /score="31.0415099" /energy="-11.4" /TU="U523,U524" /idTUdmin="U522" /TUdmin=5 /isTUend="TRUE" promotor_-35 735168..735177 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 735191..735210 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 735194 /Source="Nicolas_upshifts" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" promotor_-10 complement(735198..735216) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(735218) /Source="Nicolas_upshifts" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(735232..735237) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 735233..735670 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 19060142, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 19060142, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore inner coat protein" /protein_id="NP_388567.2" /db_xref="EnsemblGenomes-Gn:BSU06850" /db_xref="EnsemblGenomes-Tr:CAB12505" /db_xref="GOA:O31510" /db_xref="SubtiList:BG12825" /db_xref="UniProtKB/Swiss-Prot:O31510" /translation="MTDTRHMYGGPGFGHYQGFGIGHPGYGMQSTGYPGYGMYGGHPG YGMQGYPDHGIHGGVGGYPGYGGYGGYPSGGYGGSPGTGSYPSMHHENDGHHHYYHHH HDGKDNLHHHHHHVGKDNHHHHHDGHYGHHHHHMGHWGKDGYK*" gene 735233..735670 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" downshifts complement(735240) /Source="Nicolas_upshifts" /id="D339" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.62645" /MaxDrop="3.26146" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-6709" /isTUend="FALSE" downshifts 735670 /Source="Nicolas_upshifts" /id="D340" /incds=0 /nref=82 /ntot=208 /MaxReadThrough="2.37564" /MaxDrop="8.21113" /score="17.7046271" /energy="-9" /TU="U525" /idTUdmin="U523" /TUdmin=0 /isTUend="TRUE" promotor_-35 735730..735737 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 735753..735772 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 735758 /Source="Nicolas_upshifts" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" CDS 735785..736369 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR family)" /protein_id="YP_054572.1" /db_xref="EnsemblGenomes-Gn:BSU06860" /db_xref="EnsemblGenomes-Tr:CAE01448" /db_xref="GOA:Q7WY76" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14194" /db_xref="UniProtKB/Swiss-Prot:Q7WY76" /translation="MGRNKEFDTALVLHRAIEVFGEYGYEGTSLQDLLSHLGIARQSL YDTYGTKRDLFLSAVKSYLEGKNAAVMERLEAPGSVKEAIRDIFQEGVNALRDPERAK ACYIINSAIEQIPHDPELARYFERQSKQLEDAFYHGLLRAKDQGELNGEDTDISALAR YLNQSRLSLTFIAKVTADMDRLQDHVDVSLSVLD*" gene 735785..736369 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" downshifts 736350 /Source="Nicolas_upshifts" /id="D341" /incds=0 /nref=26 /ntot=216 /MaxReadThrough="2.43615" /MaxDrop="3.31193" /score="17.7046271" /energy="-9" /TU="NA" /idTUdmin="U527" /TUdmin="-2" /isTUend="TRUE" CDS 736448..736891 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388568.1" /db_xref="EnsemblGenomes-Gn:BSU06870" /db_xref="EnsemblGenomes-Tr:CAB12506" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:1S5A" /db_xref="SubtiList:BG12844" /db_xref="UniProtKB/Swiss-Prot:O31511" /translation="MLMNEFEKACETLRKFMAYMLEKDMKSWTELWDENAVFEFPYAP EGSPKRIEGKAAIYDYIKDYPKQIHLSSFTAPTVYRSADSNTVIAEFQCDGHVIETGL PYRQSYISVIETRDGRIVRYRDYWNPLVVKEAFGGSFLQTEESGK*" gene 736448..736891 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" CDS 736888..737748 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21494745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388569.1" /db_xref="EnsemblGenomes-Gn:BSU06880" /db_xref="EnsemblGenomes-Tr:CAB12507" /db_xref="GOA:O31512" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR008030" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11808" /db_xref="UniProtKB/Swiss-Prot:O31512" /translation="MMKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADA EYVYFNWKYASSFTPALEQVKQIYLVAPVGVFDPAPYVLPFLKEAKRLGAKRVVMQSA SVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRITTASGEGK LGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSIS RSELQHKMEAGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAH AAYWTSFWTE*" gene 736888..737748 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" promotor_-35 737810..737815 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 737831..737849 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 737831 /Source="Nicolas_upshifts" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" promotor_-10 complement(737853..737867) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(737858) /Source="Nicolas_upshifts" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(737875..737879) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 737875..738123 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388570.1" /db_xref="EnsemblGenomes-Gn:BSU06890" /db_xref="EnsemblGenomes-Tr:CAB12508" /db_xref="InterPro:IPR020256" /db_xref="SubtiList:BG11799" /db_xref="UniProtKB/Swiss-Prot:Q45536" /translation="MKDMQPFTPVKSYTPFHSRFDPCPPIGKKYYRTPPNLYMTFQPE HMEQFSPMEALRKGTLWKDLYDFYENPYRGGDAHGKKG*" gene 737875..738123 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" CDS 738107..738370 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388571.2" /db_xref="EnsemblGenomes-Gn:BSU06900" /db_xref="EnsemblGenomes-Tr:CAB12509" /db_xref="InterPro:IPR016571" /db_xref="InterPro:IPR024207" /db_xref="SubtiList:BG11800" /db_xref="UniProtKB/Swiss-Prot:Q45537" /translation="MAKKVDAEYYRQLEQIQAADFVLVELSLYLNTHPHDEDALKQFN QYSGYSRHLKRQFESSYGPLLQFGNSPAGKDWDWGKGPWPWQV*" gene 738107..738370 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" CDS 738385..738954 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /EC_number="1.11.1.6" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7768848, 9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7768848, 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="enzyme component of the inner spore coat" /protein_id="NP_388572.1" /db_xref="EnsemblGenomes-Gn:BSU06910" /db_xref="EnsemblGenomes-Tr:CAB12510" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG11801" /db_xref="UniProtKB/Swiss-Prot:Q45538" /translation="MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLN QRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSA LFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRF LREREIVHSMRFREAVEILKEERDKKKIF*" gene 738385..738954 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" S_feature 738955..739033 /Source="Nicolas_S_feature" /locus_tag="new_756987_757065" /HighExp="S4, S5, S3, S7, S6, B36, LoTm, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S246" promotor_-35 739006..739011 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 739026..739045 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 739035 /Source="Nicolas_upshifts" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" CDS 739079..739621 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388573.1" /db_xref="EnsemblGenomes-Gn:BSU06920" /db_xref="EnsemblGenomes-Tr:CAB12511" /db_xref="GOA:O31513" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11809" /db_xref="UniProtKB/Swiss-Prot:O31513" /translation="MTAFKIENETIADGFYACPAVYEDAESITGLLVRTAEWLRDRGS NQWSGLLKGQDIHDITGSIEKGHVFVFKKDEELAAVVMLLPAPSEWDRTLWGDDGHEE SIYLHRLAVSRRFAGQGLGARVLQWAETGIHFPEKTRIRLDCVADSDALHSFYRRMGY EFMGADASGYHLFEKEITAE*" gene 739079..739621 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" downshifts 739588 /Source="Nicolas_upshifts" /id="D342" /incds=0 /nref=104 /ntot=251 /MaxReadThrough="3.04389" /MaxDrop="4.5316" /score="8.56782582" /energy="-5.8" /TU="U528" /idTUdmin="U530" /TUdmin=2 /isTUend="TRUE" CDS 739644..739946 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388574.2" /db_xref="EnsemblGenomes-Gn:BSU06930" /db_xref="EnsemblGenomes-Tr:CAB12512" /db_xref="GOA:O31514" /db_xref="InterPro:IPR025434" /db_xref="SubtiList:BG12845" /db_xref="UniProtKB/Swiss-Prot:O31514" /translation="MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPE WMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR*" gene 739644..739946 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" promotor_-35 739989..739997 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 740008..740026 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 740014 /Source="Nicolas_upshifts" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" CDS 740061..740690 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25441682; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease or sensor of a three componentsystem for pectin and rhamnogalacturonan transport anddegradation" /protein_id="NP_388575.1" /db_xref="EnsemblGenomes-Gn:BSU06940" /db_xref="EnsemblGenomes-Tr:CAB12513" /db_xref="GOA:O31515" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12846" /db_xref="UniProtKB/Swiss-Prot:O31515" /translation="MLMIHSVANGLNHFCTWVMRLAYLNVLWILFSLAGLVVFGLMPA TAAMFTVAREWAKGNTDAPVFSVFFRTFKKEWRASQILGLIVVTAALFLFADMRIAAQ MDQPVLVNVFVSISLIFAFVVLYVFPVFSHFDVKIREVLSISFFIAFSRPAVTLLMAA GAVGVLCLVLFHVTFLLFFSGSLLSLILTKLSFKAFRSMDQRQEKEKAA*" gene 740061..740690 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" CDS 740687..742420 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 23436677, 25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 23436677, 25441682; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YesN]" /protein_id="NP_388576.1" /db_xref="EnsemblGenomes-Gn:BSU06950" /db_xref="EnsemblGenomes-Tr:CAB12514" /db_xref="GOA:O31516" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12847" /db_xref="UniProtKB/Swiss-Prot:O31516" /translation="MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVY DEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMK QELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRN LWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMI ADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVI PFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIE AGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPH FLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTI QRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK GCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRI VITIPCRNEVV*" gene 740687..742420 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" CDS 742420..743526 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25441682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YesM]" /protein_id="NP_388577.1" /db_xref="EnsemblGenomes-Gn:BSU06960" /db_xref="EnsemblGenomes-Tr:CAB12515" /db_xref="GOA:O31517" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12848" /db_xref="UniProtKB/Swiss-Prot:O31517" /translation="MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKI VHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHY LLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVA QLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKV AEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSL KWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEI GFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG*" gene 742420..743526 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" downshifts 743480 /Source="Nicolas_upshifts" /id="D343" /incds=0 /nref=4 /ntot=43 /MaxReadThrough="0.271749999999999" /MaxDrop="3.41261" /score="3.12085441" /energy="-10.3" /TU="NA" /idTUdmin="U531" /TUdmin=1408 /isTUend="FALSE" promotor_-35 743565..743568 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 743583..743602 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 743590 /Source="Nicolas_upshifts" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 743630..744913 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 25658435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 25658435; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="pectin degradation byproducts (rhamnose oligosaccharides)-binding lipoprotein" /protein_id="NP_388578.2" /db_xref="EnsemblGenomes-Gn:BSU06970" /db_xref="EnsemblGenomes-Tr:CAB12516" /db_xref="PDB:4R6K" /db_xref="SubtiList:BG12849" /db_xref="UniProtKB/Swiss-Prot:O31518" /translation="MKKICYVLLSLVCVFLFSGCSAGEEASGKKEDVTLRIAWWGGQP RHDYTTKVIELYEKKNPHVHIEAEFANWDDYWKKLAPMSAAGQLPDVIQMDTAYLAQY GKKNQLEDLTPYTKDGTIDVSSIDENMLSGGKIDNKLYGFTLGVNVLSVIANEDLLKK AGVSINQENWTWEDYEKLAYDLQEKAGVYGSNGMHPPDIFFPYYLRTKGERFYKEDGT GLAYQDDQLFVDYFERQLRLVKAKTSPTPDESAQIKGMEDDFIVKGKSAITWNYSNQY LGFARLTDSPLSLYLPPEQMQEKALTLKPSMLFSIPKSSEHKKEAAKFINFFVNNEEA NQLIKGERGVPVSDKVADAIKPKLNEEETNIVEYVETASKNISKADPPEPVGSAEVIK LLKDTSDQILYQKVSPEKAAKTFRKKANEILERNN*" gene 743630..744913 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" CDS 744910..745839 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388579.1" /db_xref="EnsemblGenomes-Gn:BSU06980" /db_xref="EnsemblGenomes-Tr:CAB12517" /db_xref="GOA:O31519" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12850" /db_xref="UniProtKB/Swiss-Prot:O31519" /translation="MTGNGADAMKKSRSIRKDNLAGYAFISPFIIGFLCFTVIPMGAS LFLSFTSYDLFTAPKWIGLDNFKEMFTGDEKYWQSLKVTFTYVLAGVPLRLGFALFIA VILNNAAKGTAIYRTLFYLPSIIGGSVAVAIMWRNIFGNDGVINALLFFVGIDQKILW YQNPTSALWTLILLSVWQFGSSMLIFLAGLKNIPSSYLEAASVDGANRVQRFFKITLP ILTPIIFFNLVMQTISAFMTFTPAYIISKGEGGPLDGTLLYSLYLFQRAFNYFQMGYA SAMAWVMLVIVGLITLILFKTSSYWVHYESKEE*" gene 744910..745839 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" CDS 745843..746733 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388580.1" /db_xref="EnsemblGenomes-Gn:BSU06990" /db_xref="EnsemblGenomes-Tr:CAB12518" /db_xref="GOA:O31520" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12851" /db_xref="UniProtKB/Swiss-Prot:O31520" /translation="MEPVNQPVREAPVFERKKAGRVSPKRILFHVFTATLAVLLLYPV IWLFVSSFKESASIFTTSHSLIPDPFILSNYAEGWKGIAGQPFLTFIKNSAIIVGLST IGAVMSSAVIAYGFARIPFKGKKFWFACMMGTLMLPHEVLMIPQYIMFAKLDWLNSFK PIVVPQFFGHAFFIFLMIQFIRTIPEELDEAARIDGCGRFACFWRIILPLIAPALATS AIFSFYWKWEELIQPLLYLNKPELYPVSLALKLFLDTESASNWGAMFAMSAVSLLPVI LVFFLFQKYIVQGISTTGLK*" gene 745843..746733 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" CDS 746749..747783 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /EC_number="3.2.1.172" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan hydrolase" /protein_id="NP_388581.1" /db_xref="EnsemblGenomes-Gn:BSU07000" /db_xref="EnsemblGenomes-Tr:CAB12519" /db_xref="GOA:O31521" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="SubtiList:BG12852" /db_xref="UniProtKB/Swiss-Prot:O31521" /translation="MAQLIFDEEKVTSVIDRIVKRTFQMDFAWDWPGGVAFYGVAEAY EATENEEYINLLKTWVDEQLEDGLPPLSINGVSIGHTLLFLHKVTGDDVYLETAAEMA EYVLHKAPRFGEGILQHTVNAAEYVFPEQAWADTLMMAGLFMLRIGRVMEREDYFEDG LRQFHGHEDVLQDPVTNLYYHAWDNKAQNHLSGIYWGRANGWAALTMAKALPLIEVTH PSFMIIDGSLRDQLSALVRLQDESGLWHTILDDPDSYLEVSASAGIASALMSSGKLYT KYVQKSLAAILDAVEEDGRVSRVSAGTAVMKNAEGYKQVPYKRIQGWGQGLALTFLAD VLKTKKRLYQ*" gene 746749..747783 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" CDS 747806..750091 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19651770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19651770; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AraC/XylS family)" /protein_id="NP_388582.1" /db_xref="EnsemblGenomes-Gn:BSU07010" /db_xref="EnsemblGenomes-Tr:CAB12520" /db_xref="GOA:O31522" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG12853" /db_xref="UniProtKB/Swiss-Prot:O31522" /translation="MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFL SIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFT FSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDH SIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQN REVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSA APLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTW QASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLR FRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQ LSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPS LFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAK ELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISEL REPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADAL GMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNR IFKKQVGMPPGVFRQMYQETP*" gene 747806..750091 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" CDS 750105..750803 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 17957779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 17957779; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388583.1" /db_xref="EnsemblGenomes-Gn:BSU07020" /db_xref="EnsemblGenomes-Tr:CAB12521" /db_xref="GOA:O31523" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12854" /db_xref="UniProtKB/Swiss-Prot:O31523" /translation="MMKKPIQVFLAGDSTVSDCPPHEAPMAGWGQVFGQLFSEGVLVR NHAKGGASTNSFVEEGRLQAIAEHITQGDYLLIQFGHNDQKPRGTKPYSTFQQFLTLF ADTAREKGAHPVFVTSVQRRRFDENGRIEHTLGEYPDAMKALAKELDVPVIDLLAKTK VLYEAYGPEESKRLFVWFQPNEHPNYPDGIEDNTHFSEKGAMEVAKLVAEGIEELGLP LKDHLVSREGKEHV*" gene 750105..750803 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" CDS 750796..751458 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388584.1" /db_xref="EnsemblGenomes-Gn:BSU07030" /db_xref="EnsemblGenomes-Tr:CAB12522" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR015305" /db_xref="PDB:1OQ1" /db_xref="SubtiList:BG12855" /db_xref="UniProtKB/Swiss-Prot:O31524" /translation="MYKEGACLYRNPLRSKSDVKDWRMEGGGQISFDDHSLHLSHVQD EAHFVFWCPETFPDGIIVTWDFSPIEQPGLCMLFFAAAGIRGEDLFDPSLRKRTGTYP EYHSGDINALHLSYFRRKYAEERAFRTCNLRKSRGFHLAAMGADPLPSPDDADSPYRM KLIKDKGYVHFSINGLPILEWMDDGSTYGPVLTKGKIGFRQMAPMKAVYRDFAVHQAV RR*" gene 750796..751458 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" CDS 751455..752081 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane component" /protein_id="NP_388585.1" /db_xref="EnsemblGenomes-Gn:BSU07040" /db_xref="EnsemblGenomes-Tr:CAB12523" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12856" /db_xref="UniProtKB/Swiss-Prot:O31525" /translation="MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTA AMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSAST NWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCML IGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG*" gene 751455..752081 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" CDS 752202..754064 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /EC_number="4.2.2.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan endolyase" /protein_id="NP_388586.1" /db_xref="EnsemblGenomes-Gn:BSU07050" /db_xref="EnsemblGenomes-Tr:CAB12524" /db_xref="GOA:O31526" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2Z8R" /db_xref="PDB:2Z8S" /db_xref="PDB:2ZUX" /db_xref="SubtiList:BG12857" /db_xref="UniProtKB/Swiss-Prot:O31526" /translation="MRRSCLMIRRRKRMFTAVTLLVLLVMGTSVCPVKAEGAARQMEA LNRGLVAVKTDGGIFVSWRFLGTENASVLFNVYRDGQKLNAAPVKTTNYVDKNGSAGS TYTVRAVVNGTEQPASEKASVWAQPYHSVPLDKPAGGTTPKGESYTYSANDASVGDVD GDGQYELILKWDPSNSKDNSQDGYTGDVLIDAYKLDGTKLWRINLGKNIRAGAHYTQF MVYDLDGDGKAEVAMKTADGTKDGTGKVIGNANADYRNEQGRVLSGPEYLTVFQGSTG KELVTANFEPARGNVSDWGDSYGNRVDRFLAGIAYLDGQRPSLIMTRGYYAKTMLVAY NFRDGKLSKLWTLDSSKSGNEAFAGQGNHNLSIADVDGDGKDEIIFGSMAVDHDGKGM YSTGLGHGDALHTGDLDPGRPGLEVFQVHEDKNAKYGLSFRDAATGKILWGVYAGKDV GRGMAADIDPRYPGQEVWANGSLYSAKGVKIGSGVPSSTNFGIWWDGDLLREQLDSNR IDKWDYQNGVSKNMLTASGAAANNGTKATPTLQADLLGDWREEVVWRTEDSSALRIYT TTIPTEHRLYTLMHDPVYRLGIAWQNIAYNQPPHTSFFLGDGMAEQPKPNMYTP*" gene 752202..754064 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" promotor_no_box 752242..752342 /Source="Nicolas_upshift_promotors" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 752302 /Source="Nicolas_upshifts" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(752840) /Source="Nicolas_upshifts" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(752841..752860) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(752873..752882) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 754110..755948 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /EC_number="4.2.2.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan exolyase" /protein_id="NP_388587.1" /db_xref="EnsemblGenomes-Gn:BSU07060" /db_xref="EnsemblGenomes-Tr:CAB12525" /db_xref="GOA:O31527" /db_xref="InterPro:IPR013517" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2ZUY" /db_xref="SubtiList:BG12858" /db_xref="UniProtKB/Swiss-Prot:O31527" /translation="MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYR DGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAK PEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAY KLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQ ADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGT AYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSV ADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDAT KPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLF TSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQ PAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDP VYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL*" gene 754110..755948 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" CDS 756106..756759 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388588.1" /db_xref="EnsemblGenomes-Gn:BSU07070" /db_xref="EnsemblGenomes-Tr:CAB12526" /db_xref="GOA:O31528" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12859" /db_xref="UniProtKB/Swiss-Prot:O31528" /translation="MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAI GGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQY IAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLA FFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER* " gene 756106..756759 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" CDS 756767..758758 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17056685, 17449691, 17485082" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17056685, 17449691, 17485082; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-galacturonidase" /protein_id="NP_388589.1" /db_xref="EnsemblGenomes-Gn:BSU07080" /db_xref="EnsemblGenomes-Tr:CAB12527" /db_xref="GOA:O31529" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12860" /db_xref="UniProtKB/Swiss-Prot:O31529" /translation="MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSV MEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMG HGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLR LWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSM EMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAF LLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCY WLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMT YSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVP YLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPM NENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVML GSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKG GSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS*" gene 756767..758758 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" CDS 758802..761375 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388590.2" /db_xref="EnsemblGenomes-Gn:BSU07090" /db_xref="EnsemblGenomes-Tr:CAB12528" /db_xref="SubtiList:BG12861" /db_xref="UniProtKB/Swiss-Prot:O31530" /translation="MKKIKWLSGQPKVTSGVTWGMPWKKGELKKGDRLALMNENAETR YVQSEPSAYWPDGSIKWTKHAAVFGGQENQSFTVHKREVPQPTESLSILETEHDIQVD TGALVCTIHKTGSDFIQSLQINGKPIAAGGRLVAIRETRKESAAKMVLLHERSVSFIK RAAIEQSGPVKAVVKIEGVHVLHKTYEEWLPFVIRLTFYAGLSEIGLVHTQLIDRSGK LEFVKGLGIEFDLFLEGEPYNRHFRFAGEKGMYKEPAQLFGTRKFNERYPLYEKQING EMLSPDEEHKEWFAHGTQNAVWDDVKIVQDSSDHYSLSKRTGKDYAWVGMLHGSRAKG LCYAGGKNGGVALGLRYFFEKYPSALEITGLAGSRPKMTIWLWPPDGEAMDLRHYTGN THVASAYEGFDEMRSDPTGIANTNEISLACFSHMPSDEVLNALADKWQAPPLIVCEPD VYYESKALGVWSIIDTSHPLKKELEEQLDAAFLFYKKEVEQRRWYGFWHYGDVMHTYD PIRHMWRYDLGGYAWQNNELVPTLWLWQAFFRSGREDIFRMAEAMTRHTSETDSFHLG EYAGLGSRHNVVHWGCGCKEARISMAGLHKFYYYLTGDDRTGDLLTEVKDADYALVKT DPMRAFYEKGKHPTHARTGPDWAAFCSNWLAEWERTENSEYLKKIETGINCLKRLPLR LLSGPTFEYDPATSMLHHMGDGIAGGYHMIIAFGAPQVWMELAELLDDWEWEDMLSEF GEFYTLSDEEKRKKSGGALHDGHFHWPMFAAGMTAYAARKKQDPHLAAKAWNLLLEDK LSHTPLPIKPERIETWTQLEELPWVTTNTVSQWCLNVIAALELIGDSLPAKKETSGKK G*" gene 758802..761375 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" promotor_-10 complement(760124..760142) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(760137) /Source="Nicolas_upshifts" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(760158..760163) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 761497..763005 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921237; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein transporter binding protein for alpha-galacturonides" /protein_id="NP_388591.1" /db_xref="EnsemblGenomes-Gn:BSU07100" /db_xref="EnsemblGenomes-Tr:CAB12529" /db_xref="GOA:P37966" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG10434" /db_xref="UniProtKB/Swiss-Prot:P37966" /translation="MKIRMRKKWMALPLAAMMIAGCSHSETSNSASGSKDTIKIMAPL LSPESPSDKSPSLKALEKYTGKEIKVTWVPDSSYNDKFNIVMASGEMPHAIVIKDKSA GFIKSVKAGAFWELSPYLKDYKNLSQADEKILKNSSVNGEVYGIYRTRDLIRACMIIR TDWLKNVGLDMPETLDDFYEVLKAFKEKDPDGNGKDDTYGMVVPKWMGLGNGSPWDVL QIWFGAPNRYGVENGKLIPDFTTKEYMDALTFFKKLYDEGLINKDFAVMDSAKWNDPV VKGKAGVIVDTGSRASQIQSAMEEADESNKDIIDIVGSLEGPNGKRTFPTSGYSGMIT IPKSSVKTEKELKEVLSFLDKMNDKEAQILTNNGVKGRNYELKDGVFTSLEKNNKSLL YEHEGLAQFSMSIPKSEYYIEDQKTKLFQHRKDIITEGEKIAVFNPAESLVSDVYTQK GAQLDNIILDARTQFIIGEIDEKGFDDAVELWKKSGGNELMKDLNKLYQSSK*" gene 761497..763005 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" CDS 763060..764016 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388592.1" /db_xref="EnsemblGenomes-Gn:BSU07110" /db_xref="EnsemblGenomes-Tr:CAB12530" /db_xref="GOA:P39128" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10435" /db_xref="UniProtKB/Swiss-Prot:P39128" /translation="METVPKKRDAPVLTAGKGISWMAALKRDKWLYLLLIPGLLYFLI FKYLPMWGVLIAFKDYSPYLGFWKSEWVGFDYFKDFFMNPDFFRLLRNTLMLASLDLL FAFPAPLILALLLNEVRKAVYKRCIQTFIYVPHFVSWTIVVSITFVFFTVDTGVINKL IMSLTGEQISFLSDADWFRPMIVMQSIWKETGWGTILFLAALATVDQEQYEAAIMDGA GRFRRMWHITLPAIRSTIIVLLILRIGSFLNLGFEQVYLMTNSLNRSVADIFDTYVYM MGITQGAYSYSTAVGLFKSVVGIILIFGANYIAKKFDQEGLF*" gene 763060..764016 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" downshifts complement(763334) /Source="Nicolas_upshifts" /id="D344" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="1.59638" /MaxDrop="4.19822" /score="13.9744253" /energy="-20.3" /TU="NA" /idTUdmin="U538" /TUdmin=2068 /isTUend="FALSE" promotor_no_box complement(763360..763460) /Source="Nicolas_upshift_promotors" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(763400) /Source="Nicolas_upshifts" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 764030..764917 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388593.1" /db_xref="EnsemblGenomes-Gn:BSU07120" /db_xref="EnsemblGenomes-Tr:CAB12531" /db_xref="GOA:P39129" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10857" /db_xref="UniProtKB/Swiss-Prot:P39129" /translation="MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFA TEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAY PLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLI IIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHA LLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAV YPFLQKHFAKGMLIGSVKG*" gene 764030..764917 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" promotor_-35 764664..764669 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 764685..764703 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 764688 /Source="Nicolas_upshifts" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" CDS 764926..766266 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23416295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23416295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-galacturonidase" /protein_id="NP_388594.1" /db_xref="EnsemblGenomes-Gn:BSU07130" /db_xref="EnsemblGenomes-Tr:CAB12532" /db_xref="GOA:P39130" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:3FEF" /db_xref="SubtiList:BG10858" /db_xref="UniProtKB/Swiss-Prot:P39130" /translation="MFHISTLDQIKIAYIGGGSQGWARSLMSDLSIDERMSGTVALYD LDFEAAQKNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISILPGSLDDMEVDVHLP ERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDYAPESWVINYTNPMSVCTRVL YKVFPGIKAIGCCHEVFGTQKLLAEMVTERLGIEVPRREDIRVNVLGINHFTWITKAS YRHIDLLPIFREFSAHYGESGYELEGECWRDSVFCSAHRVAFDLFETYGAIPAAGDRH LAEFLPGPYLKQPEVWKFHLTPISFRKQDRAEKRQETERLIVQQRGVAEKASGEEGVN IIAALLGLGELVTNVNMPNQGQVLNLPIQAIVETNAFITRNRVQPILSGALPKGVEML AARHISNQEAVADAGLTKDTGLAFQAFLNDPLVQIDRSDAEQLFNDMLQCIMQS*" gene 764926..766266 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" S_feature complement(765360..767051) /Source="Nicolas_S_feature" /locus_tag="new_783392_785083_c" /HighExp="H2O2, dia15, Paraq, Lbexp, LBGexp, Salt, LPhT, GM 25, G150, dia0" /AntisenseName="yetF" /AntisenseCor="-0.25986434675098202" /AntisenseRegPval="-4.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S247" S_feature 766267..766348 /Source="Nicolas_S_feature" /locus_tag="new_784299_784380" /HighExp="S5, S4, S6, S3, S7, S8, BT, LoTm, B36, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S248" CDS 766349..767044 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388595.1" /db_xref="EnsemblGenomes-Gn:BSU07140" /db_xref="EnsemblGenomes-Tr:CAB12533" /db_xref="GOA:O31533" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="PDB:3C6F" /db_xref="SubtiList:BG12862" /db_xref="UniProtKB/Swiss-Prot:O31533" /translation="MGNYLSVAVELVCGLGILFIILKLLGKTQFSQITPFDFISALIL GELVGNAVYDHEIKIKEIIFASLLWGVLIYIIEFITQKMKSSRKFLEGEPNIVIRKGE LQYKVMKKNKIDINQLQSLLRQAGSFSIQEVEYAILETNGMVSVLPKSDFDKPTNKDL QIPSKSVSLPITLIIDGEIVRDNLKEAGVDEQWLKQELKKKNIDKTEDVLFAEWHKNK PLYTVTYEQSRST*" gene 766349..767044 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" downshifts 767042 /Source="Nicolas_upshifts" /id="D345" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.32891" /MaxDrop="3.45213" /score="-0.176154378" /energy="-7.1" /TU="NA" /idTUdmin="U537" /TUdmin=0 /isTUend="TRUE" CDS complement(767081..767407) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /EC_number="1.14.14.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20180905, 21764939, 21873409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20180905, 21764939, 21873409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388596.2" /db_xref="EnsemblGenomes-Gn:BSU07150" /db_xref="EnsemblGenomes-Tr:CAB12534" /db_xref="GOA:O31534" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12863" /db_xref="UniProtKB/Swiss-Prot:O31534" /translation="MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNV RRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVK QGTYNQ*" gene complement(767081..767407) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" downshifts complement(767096) /Source="Nicolas_upshifts" /id="D346" /incds=0 /nref=194 /ntot=248 /MaxReadThrough="4.01189" /MaxDrop="6.29183" /score="9.23596913" /energy="-9.1" /TU="U538" /idTUdmin="U539" /TUdmin=0 /isTUend="TRUE" downshifts 767394 /Source="Nicolas_upshifts" /id="D347" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.96802" /MaxDrop="3.46057" /score="-7.34187128" /energy="-5" /TU="NA" /idTUdmin="U537" /TUdmin=352 /isTUend="FALSE" promotor_-10 complement(767430..767449) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(767448) /Source="Nicolas_upshifts" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" promotor_-35 complement(767464..767471) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(767511..767873) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase/dioxygenase" /protein_id="NP_388597.1" /db_xref="EnsemblGenomes-Gn:BSU07160" /db_xref="EnsemblGenomes-Tr:CAB12535" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12864" /db_xref="UniProtKB/Swiss-Prot:O31535" /translation="MIKQIGTVAVYVEDQQKAKQFWTEKVGFDIAADHPMGPEASWLE VAPKGAETRLVIYPKAMMKGSEQMKASIVFECEDIFGTYEKMKTNGVEFLGEPNQMEW GTFVQFKDEDGNVFLLKE*" gene complement(767511..767873) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" promotor_-10 complement(767896..767915) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-10" upshifts complement(767910) /Source="Nicolas_upshifts" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" promotor_-35 complement(767928..767934) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-35" S_feature complement(767944..768504) /Source="Nicolas_S_feature" /locus_tag="new_785976_786536_c" /HighExp="S8, S6, S7, S5, BT, B36, G/S, B60, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S249" downshifts complement(767976) /Source="Nicolas_upshifts" /id="D348" /incds=0 /nref=38 /ntot=47 /MaxReadThrough="0.395850000000001" /MaxDrop="8.2984" /score="45.4672528" /energy="-13.7" /TU="NA" /idTUdmin="U540" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(768487..768506) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(768504) /Source="Nicolas_upshifts" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" promotor_-35 complement(768520..768529) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 768592..768599 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 768608 /Source="Nicolas_upshifts" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" promotor_-10 768612..768631 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 768657..769238 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; N-terminal part of YetI" /db_xref="SubtiList:BG12865" /translation="MNIDQLLYQYIIDNTADITEKWFSLRCQLKGELYSASHLSEETK TLLTEQHTFTNITIASAFLEDQTDFQENMTKWAQNVAKNRVEQDVQVHEVVEAISNSR ISFWDAVATFIKENQEIVTNEDADRWNRIVNQSFDKLIIEFSEQYQKFMLMRLTSQQE LISELGCPVISIADGIGILPLIGSIDTKRHRSF*" gene 768657..769238 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /pseudo CDS 769232..769528 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; C-terminal part of YetI" /db_xref="GOA:O31537" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="PSEUDO:CAB12537.2" /db_xref="SubtiList:BG12873" /db_xref="UniProtKB/Swiss-Prot:O31537" /translation="MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFL LGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK*" gene 769232..769528 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /pseudo downshifts 769520 /Source="Nicolas_upshifts" /id="D349" /incds=0 /nref=114 /ntot=215 /MaxReadThrough="1.06939" /MaxDrop="4.8053" /score="16.356572" /energy="-21.2" /TU="NA" /idTUdmin="U541" /TUdmin="-8" /isTUend="TRUE" promotor_-35 769599..769606 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 769620..769639 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 769628 /Source="Nicolas_upshifts" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" CDS 769683..769850 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388600.1" /db_xref="EnsemblGenomes-Gn:BSU07190" /db_xref="EnsemblGenomes-Tr:CAB12538" /db_xref="InterPro:IPR018743" /db_xref="SubtiList:BG12875" /db_xref="UniProtKB/Swiss-Prot:O31538" /translation="MVSKSTIDPEVIEKIISSLETLDFGTVQITVHDSQITQIEKIEK HRFSLKRKESK*" gene 769683..769850 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" promotor_-35 769892..769899 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 769915..769934 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 769916 /Source="Nicolas_upshifts" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" CDS 769960..770604 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /function="7.4: Cations and iron carrying compounds" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 16086852, 24904158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 16086852, 24904158; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pH-sensitive calcium-leak permease (di-aspartyl pH sensor)" /protein_id="NP_388601.1" /db_xref="EnsemblGenomes-Gn:BSU07200" /db_xref="EnsemblGenomes-Tr:CAB12539" /db_xref="GOA:O31539" /db_xref="InterPro:IPR006214" /db_xref="PDB:4PGR" /db_xref="PDB:4PGS" /db_xref="PDB:4PGU" /db_xref="PDB:4PGV" /db_xref="PDB:4PGW" /db_xref="PDB:4TKQ" /db_xref="SubtiList:BG12866" /db_xref="UniProtKB/Swiss-Prot:O31539" /translation="MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLP LSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFG STFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIG TIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD*" gene 769960..770604 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" downshifts 770540 /Source="Nicolas_upshifts" /id="D350" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="6.69003" /MaxDrop="2.5446" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U541" /TUdmin=1012 /isTUend="FALSE" downshifts 770584 /Source="Nicolas_upshifts" /id="D351" /incds=0 /nref=7 /ntot=127 /MaxReadThrough="5.33515" /MaxDrop="3.71552" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-990" /isTUend="FALSE" CDS 770604..771596 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388602.1" /db_xref="EnsemblGenomes-Gn:BSU07210" /db_xref="EnsemblGenomes-Tr:CAB12540" /db_xref="GOA:O31540" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12867" /db_xref="UniProtKB/Swiss-Prot:O31540" /translation="MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSV VVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVF LFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMA INLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFL FFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTS VLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL*" gene 770604..771596 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" downshifts 771530 /Source="Nicolas_upshifts" /id="D352" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="4.14475" /MaxDrop="2.73453" /score="21.8095329" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-44" /isTUend="FALSE" downshifts 771574 /Source="Nicolas_upshifts" /id="D353" /incds=0 /nref=94 /ntot=214 /MaxReadThrough="0.120229999999999" /MaxDrop="4.45909" /score="21.8095329" /energy="-10.7" /TU="NA" /idTUdmin="U542" /TUdmin=0 /isTUend="TRUE" CDS complement(771620..772123) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19329649, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19329649, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (FlvL-flavonoids)" /protein_id="NP_388603.1" /db_xref="EnsemblGenomes-Gn:BSU07220" /db_xref="EnsemblGenomes-Tr:CAB12541" /db_xref="GOA:O31541" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12868" /db_xref="UniProtKB/Swiss-Prot:O31541" /translation="MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVM EHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVS RRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFE RLSVFKD*" gene complement(771620..772123) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" promotor_-10 complement(772148..772167) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(772156) /Source="Nicolas_upshifts" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" promotor_-35 complement(772181..772188) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 772286..773395 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25209494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-dependent hydroxylase/monooxygenase acting on salicylate derivatives" /protein_id="NP_388604.1" /db_xref="EnsemblGenomes-Gn:BSU07230" /db_xref="EnsemblGenomes-Tr:CAB12542" /db_xref="GOA:O06489" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12869" /db_xref="UniProtKB/Swiss-Prot:O06489" /translation="MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGIL QPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILR KTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSV VRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVF VLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWH KGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRAL KVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY*" gene 772286..773395 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" downshifts 773378 /Source="Nicolas_upshifts" /id="D354" /incds=0 /nref=7 /ntot=67 /MaxReadThrough="0.0953400000000002" /MaxDrop="5.1482" /score="13.261567" /energy="-12.6" /TU="NA" /idTUdmin="U542" /TUdmin=1804 /isTUend="FALSE" CDS complement(773430..774500) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388605.1" /db_xref="EnsemblGenomes-Gn:BSU07240" /db_xref="EnsemblGenomes-Tr:CAB12543" /db_xref="InterPro:IPR025006" /db_xref="InterPro:IPR025012" /db_xref="SubtiList:BG12870" /db_xref="UniProtKB/Swiss-Prot:O06490" /translation="MDFEIRFLSFYVIQVEGKDEQANKQFKHFQTLDTGEFEESELKD FLDGELKKIVKRKADRHPQSEQVPTKIGHFIVEPGHELDSNPNYNMFNRARLAETKED FNELSEQFVRTYLDTSAVRGGVFLVASAVPRKYFDESFVFIMKCDFEPKVARISDASS LIKKVEMAITTKNMKSIQYPYMPEEGMVEEGELKIHQASHARYFEDFLKFVEYGESMP EIMKNQVMNMVQEHVYETFEDNSEELKQFEHDIEIWEASEKREIQERLDTHQVIEASA QIIEHTPEAQLKMKVGETEIKGLLADFGDSIHLAKVNGRYVALIEAETISFEKGSSPV EFYKPEGLHEVIERIRNKTEQD*" gene complement(773430..774500) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" downshifts complement(773454) /Source="Nicolas_upshifts" /id="D355" /incds=0 /nref=45 /ntot=180 /MaxReadThrough="0.83729" /MaxDrop="4.28938" /score="0.323038441" /energy="-11.6" /TU="NA" /idTUdmin="U545" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(774531..774550) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(774557) /Source="Nicolas_upshifts" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" promotor_-35 complement(774565..774572) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 774580..774586 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 774601..774619 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 774610 /Source="Nicolas_upshifts" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" CDS 774650..777835 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /translation="MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS VQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVA RELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIK PGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQL DEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENR ELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTL SASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSA EGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQAS ITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMV GPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTV HTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQ AVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI*" gene 774650..777835 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" downshifts 777822 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" promotor_-35 777885..777890 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 777906..777924 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 777927 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" promotor_-35 777955..777958 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 777975..777994 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 777976..778281 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 777976 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" CDS 778282..780201 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" gene 778282..780201 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" downshifts 780200 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" promotor_-35 780289..780298 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 780308..780436 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 780308 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" promotor_-10 780312..780331 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(780362) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" CDS 780437..781201 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" gene 780437..781201 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" CDS 781208..782176 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" gene 781208..782176 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" CDS 782200..783111 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" gene 782200..783111 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" promotor_-35 782989..782998 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 783011..783030 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 783014 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" CDS 783140..784318 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" gene 783140..784318 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" promotor_-35 783859..783865 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 783880..783899 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 783894 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 784319..785254 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" gene 784319..785254 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" downshifts 785126 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" downshifts 785236 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" downshifts complement(785277) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" CDS complement(785285..786514) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" gene complement(785285..786514) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" promotor_-10 complement(786543..786562) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(786561) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" promotor_-35 complement(786578..786585) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(786625..787332) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" gene complement(786625..787332) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" downshifts complement(786654) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" misc_feature complement(787355..787374) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(787378) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" CDS complement(787424..788809) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" gene complement(787424..788809) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" downshifts complement(787446) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" promotor_-10 complement(788858..788877) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(788875) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" promotor_-35 complement(788892..788899) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 788977..788984 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 788992 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" promotor_-10 788998..789016 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 789059..790516 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" gene 789059..790516 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" promotor_-10 complement(789852..789871) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(789866) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(789884..789893) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 790530..791390 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" gene 790530..791390 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" downshifts 791374 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" promotor_-35 791458..791465 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 791479..791498 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 791484 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" CDS 791525..793414 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" gene 791525..793414 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" downshifts 793398 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" misc_feature 793478..793497 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 793486 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" CDS 793537..793983 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" gene 793537..793983 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" downshifts complement(793539) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" promotor_-10 complement(793623..793626) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(793628) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(793644..793645) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 793970 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" promotor_-35 794046..794053 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 794067..794086 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 794079 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" CDS 794108..794530 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" gene 794108..794530 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" downshifts 794366 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" CDS 794596..795786 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" gene 794596..795786 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" downshifts complement(795850) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" CDS 796077..796232 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" gene 796077..796232 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" CDS complement(796352..797908) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" gene complement(796352..797908) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" downshifts complement(796376) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" promotor_-35 797738..797744 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 797759..797770 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 797776 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" promotor_-10 complement(797958..797977) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(797962) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" promotor_-35 complement(797993..797997) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 798018..798021 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 798037..798056 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 798040 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" CDS 798081..799211 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" gene 798081..799211 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" downshifts 799194 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" CDS 799279..799725 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" gene 799279..799725 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" CDS complement(799778..800797) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" gene complement(799778..800797) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" downshifts complement(799788) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(800818..800837) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(800822) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" S_feature complement(800824..801278) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(800850..800857) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 800916..800923 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 800937..800956 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 800944..802041 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 800944 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" CDS complement(801279..802499) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" gene complement(801279..802499) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" promotor_-10 complement(802536..802555) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(802543) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" promotor_-35 complement(802571..802578) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 802597..802604 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 802616..802791 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 802616 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" promotor_-10 802619..802638 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 802748 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" CDS 802835..804298 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" gene 802835..804298 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" S_feature complement(803200..804870) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 804299..804792 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 804780..804785 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 804794..808059 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 804794 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" promotor_-10 804801..804819 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(804871..805671) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" gene complement(804871..805671) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" CDS complement(805684..806685) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " gene complement(805684..806685) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" promotor_-10 complement(806271..806290) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(806283) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" promotor_-35 complement(806305..806312) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(806682..807683) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " gene complement(806682..807683) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" misc_feature complement(807753..807772) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(807755..808702) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" gene complement(807755..808702) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" downshifts complement(807774) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" upshifts complement(807774) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" promotor_-35 808029..808034 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 808050..808068 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 808061..808686 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 808061 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" misc_feature 808682..808701 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 808688..809219 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 808688 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" promotor_-10 complement(808744..808763) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(808751) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" promotor_-35 complement(808777..808784) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(808811..809179) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" gene complement(808811..809179) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" S_feature complement(809180..809292) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(809281..809300) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(809292) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" promotor_-35 complement(809312..809319) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 809360..809366 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 809380..809398 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 809380 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" CDS 809423..809770 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" gene 809423..809770 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" downshifts complement(809424) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" downshifts 809766 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" S_feature 809811..809891 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 809892..809911 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 809893 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" CDS 809961..811223 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" gene 809961..811223 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" downshifts 811218 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" promotor_-35 811276..811279 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 811294..811313 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 811302 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" CDS 811350..812786 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" gene 811350..812786 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" downshifts 812778 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" misc_feature 812877..812896 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 812888 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" CDS 812913..814541 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" gene 812913..814541 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" CDS 814513..815193 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" gene 814513..815193 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" CDS 815196..816155 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" gene 815196..816155 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" downshifts 816124 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" promotor_-35 816247..816254 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 816267..816286 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 816278..816350 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 816278 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" CDS 816351..817652 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" gene 816351..817652 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" promotor_-35 817649..817655 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 817669..817680 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 817670 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" CDS 817708..818502 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" gene 817708..818502 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" downshifts 818478 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" promotor_-35 818557..818560 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 818575..818594 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 818588 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" CDS 818621..819712 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" gene 818621..819712 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" CDS complement(819703..819978) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" gene complement(819703..819978) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" S_feature 819713..820044 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(819992..820011) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(820006) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" promotor_-35 complement(820026..820033) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 820045..820710 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" gene 820045..820710 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" CDS complement(820751..820888) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" gene complement(820751..820888) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" downshifts complement(820765) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" S_feature complement(820889..821019) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(821005..821023) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 821015..821020 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(821019) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" S_feature 821030..822094 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 821031 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" promotor_-10 821036..821054 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(821039..821044) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(821045..821200) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" gene complement(821045..821200) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" S_feature complement(821201..821306) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(821307..821621) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" gene complement(821307..821621) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" S_feature complement(821622..821702) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(821703..822452) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" gene complement(821703..822452) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" promotor_-10 complement(822481..822500) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(822494) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" S_feature complement(822496..823632) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(822512..822520) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 822563..822564 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 822584..822603 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 822587 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" CDS 822624..823982 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" gene 822624..823982 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" promotor_-10 complement(823618..823637) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(823632) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" promotor_-35 complement(823651..823660) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 823868 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" downshifts 823978 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" CDS complement(824015..825964) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" gene complement(824015..825964) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" downshifts complement(824032) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" promotor_-35 825074..825080 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 825096..825114 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 825100..826064 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 825100 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" S_feature complement(825965..826039) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(826016..826035) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(826039) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" S_feature complement(826041..826563) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(826051..826055) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 826065..826202 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" gene 826065..826202 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" upshifts 826180 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" misc_feature 826181..826200 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 826221..826613 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" gene 826221..826613 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" promotor_-10 complement(826561..826579) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(826576) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" promotor_-35 complement(826595..826600) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 826682..826688 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 826703..826721 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 826703 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" CDS 826738..828153 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" gene 826738..828153 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" downshifts complement(826739) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" promotor_no_box complement(826765..826865) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(826805) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(828150..829226) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" gene complement(828150..829226) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" S_feature 828154..831520 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(829250..829450) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" gene complement(829250..829450) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" CDS complement(829466..830620) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" gene complement(829466..830620) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" CDS complement(830601..832142) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" gene complement(830601..832142) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" promotor_-10 complement(832192..832203) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(832195) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" promotor_-35 complement(832217..832223) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 832252..832259 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 832274..832293 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 832281 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" downshifts complement(832327) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" CDS 832335..833747 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" gene 832335..833747 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" promotor_no_box complement(832353..832453) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(832393) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 833818..835503 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" gene 833818..835503 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" promotor_-10 complement(834124..834139) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(834131) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(834152..834161) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 835476..835480 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 835496..835515 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 835499 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" CDS 835524..836240 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" gene 835524..836240 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" downshifts 836233 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" promotor_-35 836315..836318 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 836334..836353 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 836343 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" CDS 836380..837045 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" gene 836380..837045 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" downshifts 837026 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" CDS complement(837082..841470) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" gene complement(837082..841470) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" downshifts complement(837101) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(841503..841522) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(841520) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" promotor_-35 complement(841537..841540) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 841647..841653 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 841667..841685 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 841670 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" CDS 841713..842231 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" gene 841713..842231 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" downshifts 842217 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" downshifts complement(842261) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" S_feature 842262..843912 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(842271..843461) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" gene complement(842271..843461) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" S_feature complement(843462..843553) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(843554..843769) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" gene complement(843554..843769) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" downshifts complement(843613) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" promotor_-10 complement(843801..843820) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(843815) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" promotor_-35 complement(843835..843836) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 843882..843889 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 843904..843923 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 843914 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" CDS 843972..844442 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" gene 843972..844442 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" CDS 844460..844780 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" gene 844460..844780 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" CDS 844804..845631 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " gene 844804..845631 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" promotor_-35 845610..845616 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 845631..845642 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 845649..845805 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 845649 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" downshifts complement(845681) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" downshifts 845780 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" CDS complement(845830..847005) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " gene complement(845830..847005) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" downshifts complement(845835) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" promotor_-35 846442..846448 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 846464..846482 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 846468..847121 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 846468 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" promotor_-10 complement(847030..847049) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(847045) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" promotor_-35 complement(847063..847070) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 847111..847116 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 847123 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" promotor_-10 847131..847149 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 847173..848228 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" gene 847173..848228 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" promotor_-35 848242..848248 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 848263..848274 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 848267 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" CDS 848299..849093 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" gene 848299..849093 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" downshifts 849081 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" CDS complement(849132..849974) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" gene complement(849132..849974) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" downshifts complement(849134) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" CDS complement(849975..851096) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" gene complement(849975..851096) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" promotor_-10 complement(851137..851156) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(851155) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" promotor_-35 complement(851172..851176) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 851184..851191 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 851205..851224 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 851215 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" CDS 851241..851426 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" gene 851241..851426 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" downshifts 851405 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" promotor_-35 851469..851475 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 851481 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" promotor_-10 851490..851501 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 851527..852318 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" gene 851527..852318 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" downshifts 852316 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" CDS complement(852356..853216) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" gene complement(852356..853216) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" downshifts complement(852370) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(853236..853255) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(853250) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" promotor_-35 complement(853271..853274) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(853315..854274) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" gene complement(853315..854274) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" downshifts complement(853338) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(854285..854304) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(854288) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" promotor_-35 complement(854320..854323) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 854335..854339 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 854353..854372 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 854362 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" CDS 854393..855256 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" gene 854393..855256 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" S_feature 855257..855369 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 855370..856770 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" gene 855370..856770 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" downshifts 856782 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" promotor_-35 857076..857083 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 857099..857118 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 857105 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" S_feature 857112..857395 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 857396..857662 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" gene 857396..857662 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" promotor_-10 complement(857610..857629) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(857628) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(857644..857647) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 857663..858144 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 858115..858118 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 858135..858154 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 858146..858393 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 858146 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" CDS 858394..859371 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" gene 858394..859371 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" S_feature 859372..859464 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 859421 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" promotor_-35 859505..859511 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859523..859542 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859532 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" CDS 859567..860019 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" gene 859567..860019 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" CDS 860049..860738 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" gene 860049..860738 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" downshifts 860743 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" misc_feature 860915..860933 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 860922 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" CDS 860970..861971 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " gene 860970..861971 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" CDS 861975..863003 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" gene 861975..863003 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" CDS 863017..864213 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" gene 863017..864213 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" downshifts complement(863018) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" CDS 864234..865610 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" gene 864234..865610 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" downshifts 865604 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" promotor_-35 865657..865664 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 865677..865696 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 865685 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" CDS 865726..867543 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" gene 865726..867543 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" promotor_-35 867544..867550 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 867562 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" promotor_-10 867565..867576 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 867597..867776 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" gene 867597..867776 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" downshifts 867760 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" CDS complement(867812..868141) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" gene complement(867812..868141) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" downshifts complement(867826) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" CDS complement(868191..868649) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" gene complement(868191..868649) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" S_feature complement(868650..868742) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(868743..869300) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" gene complement(868743..869300) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" promotor_-35 869166..869171 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 869179 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" promotor_-10 869186..869204 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 869190..869777 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(869332..870099) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" gene complement(869332..870099) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" CDS complement(870111..871334) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" gene complement(870111..871334) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" CDS complement(871340..871654) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" gene complement(871340..871654) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" promotor_-10 complement(871702..871721) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(871715) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" promotor_-35 complement(871736..871739) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 871946..871965 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 871949 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" CDS 871990..873339 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " gene 871990..873339 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" misc_feature 873368..873387 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 873370 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" CDS 873404..874168 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" gene 873404..874168 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" promotor_-10 complement(873548..873562) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(873578..873584) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(873578) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 874183..875766 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" gene 874183..875766 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" downshifts 875746 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" promotor_-35 875795..875802 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 875817..875836 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 875825 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" CDS 875872..877593 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" gene 875872..877593 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" CDS 877587..879401 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" gene 877587..879401 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" downshifts 879376 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" promotor_-35 879483..879490 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 879504..879523 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 879508 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" CDS 879556..879960 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" gene 879556..879960 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" CDS 879978..880835 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" gene 879978..880835 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" downshifts 880822 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" CDS 880929..881873 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" gene 880929..881873 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" downshifts complement(881740) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" promotor_no_box complement(881788..881888) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(881828) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 882048..883496 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" gene 882048..883496 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" CDS 883523..884464 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" gene 883523..884464 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" CDS 884474..885655 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" gene 884474..885655 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" downshifts 885645 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" promotor_-35 885715..885721 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 885736..885755 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 885754 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" CDS 885779..886981 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" gene 885779..886981 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" CDS 886978..887640 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" gene 886978..887640 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" downshifts 887648 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" CDS 887784..888719 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" gene 887784..888719 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" CDS 888732..889922 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" gene 888732..889922 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" CDS 889936..891093 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" gene 889936..891093 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" promotor_-35 890047..890052 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 890067..890085 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 890068 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(891091..891165) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(891134) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" CDS complement(891166..891714) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" gene complement(891166..891714) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" S_feature complement(891715..891794) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(891783..891802) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(891794) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" promotor_-35 complement(891816..891821) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 891917..891920 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 891936..891955 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 891943 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" CDS 891987..892619 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" gene 891987..892619 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" downshifts 892598 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" promotor_-35 892734..892739 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 892753..892772 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 892763 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" CDS 892808..893896 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" gene 892808..893896 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" S_feature complement(893298..893686) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(893686) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" promotor_-10 complement(893688..893707) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(893720..893728) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(893932..894549) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" gene complement(893932..894549) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" downshifts complement(893950) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" CDS complement(894515..895768) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" gene complement(894515..895768) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" promotor_-10 complement(894576..894595) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(894588) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" promotor_-35 complement(894609..894616) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(895802..895821) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(895820) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(895836..895843) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 895847..895866 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 895852 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" CDS 895892..896428 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" gene 895892..896428 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" CDS complement(896425..897981) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" gene complement(896425..897981) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" promotor_-10 complement(898003..898021) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(898020) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(898037..898040) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(898092..898574) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" gene complement(898092..898574) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" downshifts complement(898108) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(898599..898618) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(898615) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" promotor_-35 complement(898633..898639) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 898660..898667 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 898681..898700 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 898689 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" CDS 898746..901316 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" gene 898746..901316 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" downshifts 901287 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" CDS complement(901334..902311) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" gene complement(901334..902311) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" downshifts complement(901345) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" promotor_-35 902326..902333 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(902338..902357) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 902348..902367 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 902350..902441 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 902350 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" upshifts complement(902355) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" promotor_-35 complement(902372..902379) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 902442..903443 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " gene 902442..903443 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" CDS 903440..904471 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" gene 903440..904471 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" downshifts 904452 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" promotor_-35 904522..904524 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 904540..904559 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 904543 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" CDS 904586..905467 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" gene 904586..905467 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" promotor_-35 905478..905485 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 905501..905520 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 905510 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" CDS 905555..906139 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" gene 905555..906139 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" downshifts 906126 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" CDS complement(906178..906369) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" gene complement(906178..906369) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" downshifts complement(906196) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" upshifts complement(906401) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" promotor_-10 complement(906404..906415) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(906430..906436) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(906436..906546) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" gene complement(906436..906546) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" promotor_-10 complement(906575..906586) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(906577) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" promotor_-35 complement(906601..906607) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(906601..907512) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" gene complement(906601..907512) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" promotor_-35 907398..907401 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 907418..907437 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 907428..907600 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 907428 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" promotor_-10 complement(907534..907552) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(907548) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" promotor_-35 complement(907566..907572) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 907601..908395 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" gene 907601..908395 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" CDS 908397..908711 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" gene 908397..908711 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" S_feature complement(908619..908887) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 908701 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" promotor_-35 908785..908790 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 908806..908825 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 908811 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" CDS 908854..910047 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" gene 908854..910047 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" S_feature 910048..910282 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(910080..910232) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" gene complement(910080..910232) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" downshifts complement(910097) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" promotor_-35 910261..910268 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 910282..910301 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 910284..910356 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 910284 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" promotor_-10 complement(910291..910302) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(910301) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" promotor_-35 complement(910317..910323) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 910357..910626 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" gene 910357..910626 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" downshifts 910615 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" promotor_-35 910704..910710 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 910725 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" promotor_-10 910726..910744 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 910771..911289 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" gene 910771..911289 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" S_feature 911290..911357 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 911325..911334 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 911346..911361 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 911359 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" CDS 911374..911706 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" gene 911374..911706 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" CDS 911693..912553 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" gene 911693..912553 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" downshifts 912551 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" promotor_-35 912611..912617 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 912631..912642 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 912639..912703 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 912639 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" promotor_-10 complement(912661..912680) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(912670) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 912686..912692 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(912694..912695) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 912705..912785 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 912705 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" promotor_-10 912707..912725 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 912786..913775 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" gene 912786..913775 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" upshifts complement(912935) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(912940..912944) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(912961..912965) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 913776..913846 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 913847..916432 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" gene 913847..916432 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" downshifts 916401 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" CDS complement(916425..917408) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" gene complement(916425..917408) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" downshifts complement(916459) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" promotor_-35 916882..916891 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 916904..916923 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 916908 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(917409..917556) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 917513..917517 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 917533..917552 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 917540 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" S_feature 917546..917623 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(917554..917573) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(917556) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" promotor_-35 complement(917588..917595) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 917624..918733 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" gene 917624..918733 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" promotor_-35 918570..918574 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 918590..918609 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 918602 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" S_feature 918734..919046 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(918741..918965) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" gene complement(918741..918965) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" promotor_-10 complement(918995..919006) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(918997) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" promotor_-35 complement(919020..919026) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 919047..919799 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" gene 919047..919799 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" promotor_-35 919816..919822 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 919837..919848 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 919838 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" promotor_-10 complement(919845..919859) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(919866) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(919868..919872) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 919868..920122 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" gene 919868..920122 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" downshifts 920120 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" downshifts complement(920145) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" CDS 920211..920555 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" gene 920211..920555 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" promotor_-35 920218..920226 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 920237..920255 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 920239 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" downshifts 920538 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" promotor_-35 920594..920601 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 920615..920634 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 920624..920698 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 920624 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" CDS 920699..921229 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" gene 920699..921229 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" downshifts 921220 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" CDS 921317..923059 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" gene 921317..923059 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" downshifts 923046 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" CDS complement(923136..924197) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" gene complement(923136..924197) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" downshifts complement(923147) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" S_feature complement(924198..924288) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(924286..924305) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(924295) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" promotor_-35 complement(924320..924327) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(924417..925706) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" gene complement(924417..925706) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" downshifts complement(924420) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(925734..925753) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(925753) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" S_feature complement(925755..926466) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(925765..925770) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 925799..925806 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 925820..925839 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 925820 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" CDS 925859..926332 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" gene 925859..926332 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" promotor_-35 926369..926376 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926391..926410 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926397 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" CDS 926455..926892 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" gene 926455..926892 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" downshifts 926874 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" CDS complement(926927..927280) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" gene complement(926927..927280) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" downshifts 926940 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" downshifts complement(926950) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" promotor_-35 927276..927280 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 927288..927302 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(927292..927311) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 927292..927383 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 927292 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" upshifts complement(927302) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" promotor_-35 927360..927363 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 927378..927397 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 927385..927487 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 927385 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" CDS 927488..928372 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" gene 927488..928372 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" promotor_-35 928355..928362 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 928376..928395 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 928391..928663 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 928391 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" downshifts complement(928424) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" rRNA 928664..930218 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 928664..930218 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" rRNA 930386..933313 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 930386..933313 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" S_feature 933314..933399 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 933375..933382 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 933396..933415 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 933401 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" rRNA 933425..933540 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 933425..933540 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" tRNA 933550..933624 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 933550..933624 /gene="asnTA" /locus_tag="BSU_tRNA_29" tRNA 933630..933721 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 933630..933721 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" downshifts 933717 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" tRNA 933756..933827 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 933756..933827 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" tRNA 933837..933912 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 933837..933912 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" tRNA 933922..933998 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 933922..933998 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" tRNA 934010..934086 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 934010..934086 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" tRNA 934099..934174 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 934099..934174 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" tRNA 934180..934252 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 934180..934252 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" tRNA 934275..934359 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 934275..934359 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" tRNA 934365..934438 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 934365..934438 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" tRNA 934463..934538 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 934463..934538 /gene="trnD-His" /locus_tag="BSU_tRNA_39" tRNA 934548..934619 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 934548..934619 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" tRNA 934669..934743 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 934669..934743 /gene="glyTB" /locus_tag="BSU_tRNA_41" tRNA 934749..934819 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 934749..934819 /gene="cysTA" /locus_tag="BSU_tRNA_42" tRNA 934827..934915 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 934827..934915 /gene="leuTA" /locus_tag="BSU_tRNA_43" S_feature 934916..934992 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 934949 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" S_feature 934994..935162 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 935119..935126 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 935125 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" promotor_-10 935140..935159 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 935164 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" tRNA 935181..935262 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 935181..935262 /gene="leuTB" /locus_tag="BSU_tRNA_44" promotor_-10 complement(935198..935215) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(935201) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(935236..935241) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(935271) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" CDS complement(935341..936117) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" gene complement(935341..936117) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" downshifts complement(935355) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(936144..936159) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(936166) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" promotor_-35 complement(936172..936181) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 936201..936207 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 936222..936233 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 936225 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" CDS 936259..936462 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" gene 936259..936462 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" downshifts 936445 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" downshifts complement(936521) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" CDS complement(936547..936819) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" gene complement(936547..936819) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" promotor_-10 complement(936778..936796) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(936785) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" promotor_-35 936800..936807 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(936813..936818) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 936820..936839 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 936828 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" CDS 936861..937553 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" gene 936861..937553 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" promotor_-35 937582..937586 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(937585..937604) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(937597) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 937600..937619 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(937619..937626) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 937623..937730 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene 937623..937730 /gene="tswD" /locus_tag="BSU_misc_RNA_11" upshifts 937630 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" downshifts 937761 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" CDS 937863..939635 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" gene 937863..939635 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" downshifts 939611 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" S_feature 939656..940581 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(939673..941028) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" gene complement(939673..941028) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" promotor_-10 complement(941056..941075) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(941073) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" promotor_-35 complement(941089..941098) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 941146..941152 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 941167..941186 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 941195 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" CDS 941279..941476 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" gene 941279..941476 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" CDS complement(941503..942954) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" gene complement(941503..942954) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" downshifts complement(941513) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" promotor_-35 942931..942937 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 942952..942971 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 942955 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" promotor_-10 complement(942972..942991) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 942977..943306 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(942991) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" promotor_-35 complement(943005..943012) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(943050..943068) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(943075) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" downshifts 943263 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" CDS 943362..944129 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" gene 943362..944129 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" CDS 944147..945145 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" gene 944147..945145 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" CDS 945142..945972 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" gene 945142..945972 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" CDS 945995..947125 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" gene 945995..947125 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" misc_feature 947152..947171 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 947158 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" CDS 947229..947765 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" gene 947229..947765 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" S_feature 947766..947836 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 947806..947813 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 947827..947846 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 947838 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" CDS 947877..948146 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" gene 947877..948146 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" promotor_-35 947949..947953 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 947976..947992 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 947992 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 948133 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" CDS complement(948164..948637) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" gene complement(948164..948637) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" downshifts complement(948200) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" CDS complement(948639..948839) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" gene complement(948639..948839) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" promotor_-10 complement(948868..948887) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(948882) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" promotor_-35 complement(948900..948907) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 948963..948968 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 948982..949001 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 948982 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" tRNA 949033..949106 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 949033..949106 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" S_feature 949107..949289 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(949197..949820) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" gene complement(949197..949820) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" downshifts complement(949212) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" downshifts 949246 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" S_feature 949291..949902 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(949844..949863) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(949865) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" promotor_-35 complement(949877..949884) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 949903..951063 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" gene 949903..951063 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" downshifts 951072 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" misc_feature 951089..951101 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 951094 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" CDS 951130..952065 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" gene 951130..952065 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" downshifts complement(951148) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" promotor_-35 952049..952052 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 952067 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" promotor_-10 952068..952087 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 952103..952585 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" gene 952103..952585 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" downshifts 952568 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" CDS 952635..953351 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" gene 952635..953351 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" promotor_-35 952655..952662 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 952677..952696 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 952678 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" CDS 953342..954055 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" gene 953342..954055 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" CDS 954067..954774 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" gene 954067..954774 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" downshifts 954658 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" downshifts 954702 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" downshifts 954768 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" S_feature complement(954801..954976) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(954844) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" promotor_-10 complement(954968..954987) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(954976) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" promotor_-35 complement(955002..955009) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 955041..955046 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 955062..955080 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 955062 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" CDS 955124..957019 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" gene 955124..957019 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" promotor_no_box 955566..955666 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 955626 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 955692 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" downshifts 957012 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" promotor_-35 957076..957081 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 957097..957115 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 957100..957198 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 957100 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" CDS 957199..958377 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" gene 957199..958377 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" promotor_-35 957397..957400 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 957415..957434 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 957419 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts complement(957660) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" downshifts 958356 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" promotor_-35 958464..958471 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 958486..958505 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 958486 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" CDS 958537..959001 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" gene 958537..959001 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" promotor_-35 958826..958832 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 958847..958865 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 958860 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" promotor_-35 959010..959016 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 959030..959041 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 959036 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" CDS 959037..959702 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" gene 959037..959702 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" CDS 959743..961341 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" gene 959743..961341 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" CDS 961364..961894 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" gene 961364..961894 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" CDS 961907..962281 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" gene 961907..962281 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" downshifts 962270 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" CDS 962281..962436 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" gene 962281..962436 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" promotor_-35 962371..962377 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 962392..962411 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 962402 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" CDS 962441..963202 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" gene 962441..963202 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" promotor_-10 complement(962754..962772) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(962768) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(962788..962793) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 963205..963570 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" gene 963205..963570 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" CDS 963572..964270 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" gene 963572..964270 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" CDS 964287..965204 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" gene 964287..965204 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" CDS 965197..966138 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" gene 965197..966138 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" downshifts 966120 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" CDS complement(966230..966433) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" gene complement(966230..966433) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" downshifts complement(966244) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" S_feature complement(966434..966561) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 966521..966532 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 966538 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(966550..966569) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(966561) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" S_feature complement(966563..967701) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(966583..966588) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 966728..966735 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 966750..966768 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 966757 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" S_feature 966758..966868 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 966869..967699 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" gene 966869..967699 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" downshifts 967658 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" CDS complement(967702..968781) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" gene complement(967702..968781) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" promotor_-10 complement(968791..968810) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(968812) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" promotor_-35 complement(968826..968830) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 968888..968895 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 968909..968928 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 968915 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" CDS 968954..970345 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" gene 968954..970345 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" S_feature complement(969981..970384) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 970324 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" CDS complement(970385..970840) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" gene complement(970385..970840) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" promotor_-10 complement(970855..970873) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(970883) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" promotor_-35 complement(970888..970894) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 970932..970938 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 970952..970963 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 970956 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" CDS 970990..971559 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" gene 970990..971559 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" promotor_-35 971186..971192 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 971203 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 971206..971217 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 971534 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" promotor_-35 971602..971611 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 971625..971644 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 971635 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" CDS 971680..972648 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" gene 971680..972648 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" downshifts 972524 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" CDS complement(972580..973233) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " gene complement(972580..973233) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" downshifts complement(972597) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" promotor_-10 complement(973264..973275) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(973266) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" promotor_-35 complement(973290..973296) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 973305..973313 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 973316..976969 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" gene 973316..976969 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" promotor_-10 973324..973342 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 973339 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" CDS 976966..977562 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" gene 976966..977562 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" downshifts 977541 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" CDS complement(977592..978500) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" gene complement(977592..978500) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" promotor_-35 978556..978564 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(978557..978568) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(978563) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" S_feature complement(978565..979051) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 978575 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" promotor_-10 978578..978597 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(978582..978588) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 978611..979006 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" gene 978611..979006 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" misc_feature complement(979037..979056) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(979051) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" promotor_-35 979091..979097 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 979106 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" promotor_-10 979111..979122 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(979121..979135) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(979135) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(979143..979147) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 979143..979565 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" gene 979143..979565 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" promotor_no_box complement(979469..979569) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(979509) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 979543 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" downshifts complement(979575) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" promotor_-35 979615..979622 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 979636..979655 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 979644 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" CDS 979692..980354 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" gene 979692..980354 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" CDS 980370..981911 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" gene 980370..981911 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" downshifts 981894 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" CDS 981995..982186 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" gene 981995..982186 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo promotor_-35 982217..982224 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 982239..982258 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 982250..982331 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 982250 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" CDS 982332..983684 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" gene 982332..983684 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" CDS 983712..984290 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" gene 983712..984290 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" promotor_-35 984285..984292 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 984307..984326 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 984318 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" downshifts 984333 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" S_feature 984378..984468 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 984469..985293 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" gene 984469..985293 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" CDS 985312..986802 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" gene 985312..986802 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" promotor_-35 986113..986119 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 986134..986153 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 986144 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" S_feature 986803..986891 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 986848 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" promotor_no_box 986854..986954 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 986914 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" CDS 986943..988610 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" gene 986943..988610 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" promotor_-35 988372..988377 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 988392..988410 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 988401 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" promotor_-35 988455..988461 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 988476 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" promotor_-10 988477..988495 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 988578 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" S_feature 988623..988696 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 988678..988685 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 988698 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" promotor_-10 988699..988718 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 988742..990487 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" gene 988742..990487 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" downshifts 990476 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" S_feature 990521..990590 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 990592..990611 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 990592 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" CDS 990636..991775 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" gene 990636..991775 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" CDS 991772..992416 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" gene 991772..992416 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" CDS 992413..992937 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" gene 992413..992937 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" downshifts 992902 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" CDS complement(992952..993194) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" gene complement(992952..993194) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" downshifts complement(992973) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" promotor_-10 complement(993230..993241) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(993241) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" promotor_-35 complement(993255..993262) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 993329..993335 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 993349..993360 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 993359 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" CDS 993395..993718 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" gene 993395..993718 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" S_feature 993719..995585 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(993760..995226) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" gene complement(993760..995226) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" downshifts complement(993772) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" downshifts complement(993859) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(995266..995284) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(995278) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" promotor_-35 complement(995298..995305) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(995379..995819) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" gene complement(995379..995819) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" downshifts complement(995409) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" promotor_-35 995807..995813 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 995827..995838 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 995829..995939 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 995829 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" promotor_-10 complement(995841..995860) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(995857) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" promotor_-35 complement(995872..995878) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 995898 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" CDS complement(995926..997584) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" gene complement(995926..997584) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" downshifts complement(995931) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" promotor_-10 complement(997475..997493) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(997495) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" promotor_-35 complement(997507..997513) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 997556..997561 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 997577..997595 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 997590 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" CDS 997615..999021 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" gene 997615..999021 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" downshifts 999001 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" CDS complement(999051..1000436) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" gene complement(999051..1000436) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" downshifts complement(999077) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" upshifts complement(1000463) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" S_feature complement(1000465..1001996) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(1000473..1000484) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1000592..1000599 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1000612..1000631 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1000618..1000905 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 1000618 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" promotor_-35 1000868..1000871 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1000886..1000905 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1000907 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" CDS 1000966..1001970 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" gene 1000966..1001970 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" downshifts 1001832 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" downshifts 1001962 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" upshifts complement(1001996) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" promotor_-10 complement(1002003..1002018) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1002008 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" promotor_-35 complement(1002030..1002039) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1002041..1002916) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" gene complement(1002041..1002916) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" promotor_-35 1002969..1002970 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1002982..1003001) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 1002987..1003006 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1002988) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" upshifts 1002997 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" promotor_-35 complement(1003016..1003021) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 1003025..1004125 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" gene 1003025..1004125 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" promotor_-35 1004136..1004142 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1004157..1004175 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1004162 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" CDS 1004199..1005068 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" gene 1004199..1005068 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" downshifts 1005076 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" promotor_-35 1005153..1005156 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1005168 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" promotor_-10 1005171..1005190 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 1005216..1005235 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1005221..1005317 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 1005221 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" CDS 1005318..1006715 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" gene 1005318..1006715 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" downshifts 1006695 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" promotor_-35 1006776..1006780 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1006796..1006815 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1006803 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" CDS 1006833..1008188 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" gene 1006833..1008188 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" downshifts 1008169 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" CDS complement(1008223..1009632) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" gene complement(1008223..1009632) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" promotor_-35 1009681..1009684 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1009699..1009718 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1009701 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" promotor_-10 complement(1009703..1009722) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1009715) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" promotor_-35 complement(1009738..1009742) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1009742..1010170 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" gene 1009742..1010170 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" downshifts 1010149 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" CDS complement(1010201..1010491) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" gene complement(1010201..1010491) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" downshifts complement(1010225) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" CDS complement(1010479..1011555) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" gene complement(1010479..1011555) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" CDS complement(1011545..1012036) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" gene complement(1011545..1012036) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" S_feature complement(1012037..1012139) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(1012128..1012147) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1012139) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" promotor_-35 complement(1012161..1012164) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1012177..1012183 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1012194 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" promotor_-10 1012198..1012216 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1012227) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" CDS 1012233..1013228 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" gene 1012233..1013228 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" downshifts 1013207 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" promotor_-35 1013290..1013293 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1013308..1013327 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1013313 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" CDS 1013363..1013962 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" gene 1013363..1013962 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" downshifts 1013977 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" S_feature 1014022..1015976 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(1014031..1015365) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" gene complement(1014031..1015365) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" downshifts complement(1014050) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" CDS complement(1015426..1015857) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" gene complement(1015426..1015857) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" promotor_-10 complement(1015869..1015888) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1015879) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" promotor_-35 complement(1015903..1015909) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(1015905..1016005) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 1015940..1015947 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(1015945) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1015961..1015980 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 1015978 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" CDS 1016014..1017195 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" gene 1016014..1017195 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" downshifts 1017180 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" S_feature 1017225..1017363 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 1017359..1017378 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1017365..1017521 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 1017365 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" CDS 1017522..1018907 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" gene 1017522..1018907 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" downshifts 1018797 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" downshifts 1018883 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" CDS complement(1018921..1019277) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" gene complement(1018921..1019277) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" CDS complement(1019274..1019669) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" gene complement(1019274..1019669) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" CDS complement(1019656..1020387) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" gene complement(1019656..1020387) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" misc_feature complement(1020412..1020431) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1020433) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" promotor_-35 1020480..1020488 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1020497 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" promotor_-10 1020502..1020517 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1020511..1020584 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 1020571..1020572 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1020586 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" promotor_-10 1020588..1020607 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1020621..1020728 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" gene 1020621..1020728 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" S_feature 1020729..1020782 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 1020753 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" misc_feature 1020833..1020852 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1020839 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" CDS 1020877..1021992 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" gene 1020877..1021992 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" downshifts 1021972 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" misc_feature 1022029..1022048 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1022029 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" CDS 1022062..1022805 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" gene 1022062..1022805 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" downshifts 1022777 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" CDS complement(1022829..1023677) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" gene complement(1022829..1023677) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" downshifts complement(1022853) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" promotor_-35 1023673..1023678 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1023678..1023777) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 1023694..1023712 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1023696 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" S_feature 1023701..1023896 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(1023766..1023785) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1023780) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" promotor_-35 complement(1023800..1023803) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1023895..1023914 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1023898..1023961 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 1023898 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" CDS 1023962..1024810 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" gene 1023962..1024810 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" downshifts 1024801 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" CDS complement(1024853..1026214) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" gene complement(1024853..1026214) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" downshifts complement(1024877) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" S_feature complement(1026215..1026285) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(1026258..1026277) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1026285) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" CDS complement(1026341..1026841) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" gene complement(1026341..1026841) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" downshifts complement(1026373) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" promotor_-10 complement(1026863..1026881) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1026883) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" promotor_-35 complement(1026896..1026902) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1026920..1026927 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1026935..1027004 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 1026936 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" promotor_-10 1026942..1026961 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1027005..1027166 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" gene 1027005..1027166 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" downshifts 1027096 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" S_feature 1027167..1027285 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 1027286..1029043 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" gene 1027286..1029043 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" CDS 1029040..1031061 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" gene 1029040..1031061 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" downshifts 1031049 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" CDS complement(1031110..1031730) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" gene complement(1031110..1031730) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" downshifts complement(1031125) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" promotor_no_box 1031715..1031815 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1031744..1031763) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1031759) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" CDS complement(1031769..1031894) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" gene complement(1031769..1031894) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" upshifts 1031775 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1031778..1031781) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1031908..1031927) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1031917) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" promotor_-35 complement(1031941..1031950) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1031973 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" CDS complement(1031999..1032202) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" gene complement(1031999..1032202) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" downshifts complement(1032004) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" S_feature complement(1032203..1032313) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 1032243..1032343 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1032303 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1032319) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" promotor_-10 complement(1032323..1032334) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1032349..1032355) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1032411..1032629) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" gene complement(1032411..1032629) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" downshifts complement(1032445) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" promotor_-10 complement(1032670..1032689) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1032687) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" promotor_-35 complement(1032703..1032710) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1032779..1034140) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" gene complement(1032779..1034140) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" downshifts complement(1032797) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" downshifts complement(1032841) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" CDS complement(1034130..1035221) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" gene complement(1034130..1035221) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" promotor_-10 complement(1034545..1034559) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1034557) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1034573..1034581) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1035222..1035327) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(1035311..1035329) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1035331) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" promotor_-35 complement(1035345..1035350) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1035393..1035400 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1035415..1035434 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1035426 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" CDS 1035488..1036621 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" gene 1035488..1036621 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" S_feature 1036622..1036713 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 1036714..1037067 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" gene 1036714..1037067 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" downshifts 1037055 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" CDS complement(1037111..1038184) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" gene complement(1037111..1038184) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" downshifts complement(1037218) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" promotor_-10 complement(1038206..1038225) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1038218) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" promotor_-35 complement(1038239..1038246) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1038321..1038328 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1038341 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" promotor_-10 1038343..1038362 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1038352..1038505 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 1038462 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" S_feature 1038507..1038590 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 1038547 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" promotor_-35 1038603..1038608 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1038624..1038642 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1038633 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" CDS 1038670..1039536 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" gene 1038670..1039536 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" downshifts 1039518 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" promotor_-35 1039581..1039584 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1039599..1039618 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1039607 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" CDS 1039648..1041153 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" gene 1039648..1041153 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" downshifts 1041123 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" CDS complement(1041171..1042388) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" gene complement(1041171..1042388) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" downshifts complement(1041177) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" CDS complement(1042395..1042892) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" gene complement(1042395..1042892) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" CDS complement(1042956..1043294) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" gene complement(1042956..1043294) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" promotor_-10 complement(1043306..1043325) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1043330) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" promotor_-35 complement(1043339..1043346) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1043366..1043373 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1043388..1043407 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1043398 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" CDS 1043459..1044226 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" gene 1043459..1044226 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" downshifts 1044227 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" CDS complement(1044247..1044432) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" gene complement(1044247..1044432) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" promotor_-10 complement(1044468..1044486) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1044479) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" promotor_-35 complement(1044497..1044505) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1044506..1044509 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1044524..1044543 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1044534 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" CDS 1044559..1045455 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" gene 1044559..1045455 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" CDS 1045448..1046707 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" gene 1045448..1046707 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" downshifts 1046691 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" promotor_-35 1046755..1046762 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1046774..1046793 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1046779 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" CDS 1046814..1048040 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" gene 1046814..1048040 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" downshifts complement(1047515) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" CDS 1048045..1050936 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" gene 1048045..1050936 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" promotor_-35 1049326..1049331 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1049347..1049365 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1049353 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" promotor_-35 1050944..1050949 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1050964..1050983 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1050979 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" CDS 1051010..1051954 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" gene 1051010..1051954 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" downshifts 1051932 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" promotor_-35 1052013..1052018 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1052034..1052052 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1052037 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" CDS 1052079..1052291 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" gene 1052079..1052291 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" downshifts 1052284 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" downshifts complement(1052322) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" CDS complement(1052332..1053210) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" gene complement(1052332..1053210) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" downshifts complement(1052520) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" promotor_-10 complement(1053248..1053267) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1053272) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" promotor_-35 complement(1053281..1053288) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1053308..1053317 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1053329 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" promotor_-10 1053330..1053349 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1053366..1053380) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1053367) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1053370..1053456 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" gene 1053370..1053456 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" promotor_-35 complement(1053389..1053393) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1053457..1053708 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 1053581..1053667 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" gene 1053581..1053667 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" downshifts 1053665 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" S_feature complement(1053677..1053939) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 1053710..1054193 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(1053720) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(1053932..1053951) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1053939) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" S_feature complement(1053941..1054009) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(1053965..1053970) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1054010..1054528) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" gene complement(1054010..1054528) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" promotor_-35 1054315..1054323 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1054335..1054353 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1054348 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1054559..1054578) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1054577) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" promotor_-35 complement(1054594..1054600) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1054677..1054680 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1054695..1054714 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1054700 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" CDS 1054736..1055077 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" gene 1054736..1055077 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" S_feature complement(1054931..1055073) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(1054974) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" CDS complement(1055074..1055685) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" gene complement(1055074..1055685) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" S_feature 1055078..1055843 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(1055150) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" promotor_-35 1055681..1055685 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1055693..1055706 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1055705 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1055710..1055729) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(1055733) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" promotor_-35 complement(1055744..1055747) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 1055800 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" CDS complement(1055863..1056219) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" gene complement(1055863..1056219) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" downshifts complement(1055867) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" promotor_-35 1056296..1056301 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1056302..1056321) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1056316) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" promotor_-10 1056317..1056335 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1056317 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" S_feature complement(1056318..1056581) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 1056349..1056540 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" gene 1056349..1056540 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" S_feature 1056541..1057976 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(1056614..1057132) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" gene complement(1056614..1057132) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" downshifts complement(1056626) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" S_feature complement(1057133..1057220) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(1057212..1057231) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1057220) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" promotor_-35 complement(1057245..1057252) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1057257..1058336) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" gene complement(1057257..1058336) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" misc_feature complement(1058375..1058394) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1058386) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" S_feature complement(1058388..1058469) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(1058483..1058920) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" gene complement(1058483..1058920) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" downshifts complement(1058514) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" promotor_-10 complement(1058953..1058972) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1058967) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" downshifts 1058970 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" promotor_-35 complement(1058986..1058993) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1058992..1059288) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(1059035) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" promotor_-10 complement(1059286..1059297) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1059292) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" promotor_-35 complement(1059312..1059318) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1059348..1059355 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1059369..1059388 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1059378 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" CDS 1059408..1060151 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" gene 1059408..1060151 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" CDS 1060144..1061370 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" gene 1060144..1061370 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" promotor_-10 complement(1060703..1060721) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1060718) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1060737..1060742) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1061390..1062100 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" gene 1061390..1062100 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" downshifts 1062064 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" CDS complement(1062118..1063308) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" gene complement(1062118..1063308) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" downshifts complement(1062128) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" downshifts complement(1062193) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" promotor_-10 complement(1063332..1063351) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1063353) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" promotor_-35 complement(1063365..1063370) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1063381..1064772) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" gene complement(1063381..1064772) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" promotor_-10 complement(1064783..1064802) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1064788) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" promotor_-35 complement(1064815..1064824) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1064838..1065152) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" gene complement(1064838..1065152) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" CDS complement(1065197..1065697) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" gene complement(1065197..1065697) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" downshifts complement(1065224) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" promotor_-10 complement(1065710..1065729) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1065712..1065716 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1065731) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" promotor_-10 1065732..1065751 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1065733 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" promotor_-35 complement(1065746..1065747) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1065764..1065770 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1065785..1065796 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1065790 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" CDS 1065819..1067963 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" gene 1065819..1067963 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" promotor_-10 complement(1065863..1065874) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1065866) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1065888..1065894) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1068000..1068006 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1068020..1068039 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1068030 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" CDS 1068085..1069146 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" gene 1068085..1069146 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" CDS 1069218..1070150 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" gene 1069218..1070150 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" CDS 1070165..1071577 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" gene 1070165..1071577 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" downshifts 1070168 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" downshifts 1071554 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" promotor_-35 1071638..1071645 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1071659..1071678 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1071664 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" CDS 1071723..1072298 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" gene 1071723..1072298 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" promotor_-35 1072042..1072045 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1072060 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" promotor_-10 1072062..1072081 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1072299..1072368 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 1072369..1074696 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" gene 1072369..1074696 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" downshifts 1074678 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" CDS complement(1074738..1075715) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" gene complement(1074738..1075715) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" downshifts complement(1074751) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" promotor_-10 complement(1075729..1075748) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1075747) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" promotor_-35 complement(1075762..1075768) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1075774..1075782 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1075793..1075811 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1075800 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" CDS 1075842..1076618 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" gene 1075842..1076618 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" S_feature complement(1076334..1076955) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 1076619..1076990 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(1076933..1076952) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1076954) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" promotor_-35 complement(1076966..1076975) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1076968..1076975 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1076990..1077009 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1076992 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" CDS 1077031..1078071 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" gene 1077031..1078071 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" CDS 1078084..1078491 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" gene 1078084..1078491 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" downshifts 1078462 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" CDS complement(1078528..1079817) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" gene complement(1078528..1079817) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" downshifts complement(1078558) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" S_feature complement(1079818..1079918) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(1079917..1079936) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1079918) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" S_feature complement(1079920..1080056) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(1079951..1079957) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1080088..1080228) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" gene complement(1080088..1080228) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" downshifts complement(1080101) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" promotor_-10 complement(1080247..1080266) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1080266) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" promotor_-35 complement(1080279..1080286) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1080310..1080316 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1080330..1080349 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1080333 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" CDS 1080380..1081114 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" gene 1080380..1081114 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" CDS 1081127..1082122 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" gene 1081127..1082122 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" CDS 1082187..1082831 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" gene 1082187..1082831 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" downshifts 1082819 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" promotor_-35 1082859..1082862 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1082877..1082896 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1082884 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" CDS 1082948..1084489 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" gene 1082948..1084489 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" downshifts 1084469 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" CDS complement(1084528..1084923) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" gene complement(1084528..1084923) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" downshifts complement(1084545) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1084943..1084954) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1084947) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" promotor_-35 complement(1084969..1084975) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1085008..1085011 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1085019 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" promotor_-10 1085026..1085045 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1085072..1086352 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" gene 1085072..1086352 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" promotor_-10 complement(1085499..1085518) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1085513) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1085534..1085539) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1086339 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" downshifts complement(1086389) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" CDS complement(1086391..1087536) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" gene complement(1086391..1087536) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" S_feature complement(1087537..1087603) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(1087592..1087611) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1087609) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" promotor_-35 complement(1087627..1087631) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1087916..1087923 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 1087938..1087957 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 1087940 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" CDS 1087971..1088420 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" gene 1087971..1088420 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" promotor_-35 1088436..1088443 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1088458..1088477 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1088465 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" CDS 1088492..1089484 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" gene 1088492..1089484 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" downshifts 1089485 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" S_feature 1089530..1089640 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 1089618..1089625 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1089641..1089660 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1089642 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" CDS 1089701..1090672 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" gene 1089701..1090672 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" downshifts 1090651 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" CDS complement(1090704..1091285) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" gene complement(1090704..1091285) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" downshifts complement(1090727) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1091309..1091328) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1091321) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" promotor_-35 complement(1091344..1091347) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1091356..1092450) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" gene complement(1091356..1092450) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" CDS complement(1092447..1093886) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" gene complement(1092447..1093886) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" CDS complement(1093893..1094453) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" gene complement(1093893..1094453) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" misc_feature complement(1093903..1093922) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1093917) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" promotor_-10 complement(1094478..1094497) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1094492) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" promotor_-35 complement(1094512..1094519) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1094588..1095886) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" gene complement(1094588..1095886) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" downshifts complement(1094599) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1095940..1095958) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1095943) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" promotor_-35 complement(1095972..1095978) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1096025..1097554) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" gene complement(1096025..1097554) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" promotor_-10 complement(1097581..1097599) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1097591) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" promotor_-35 1097610..1097615 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1097614..1097619) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1097627 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" promotor_-10 1097631..1097649 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1097666..1098523 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" gene 1097666..1098523 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" downshifts 1098505 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" CDS complement(1098551..1098784) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" gene complement(1098551..1098784) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" downshifts complement(1098584) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" promotor_-10 complement(1098801..1098820) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1098804..1098805 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1098804 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" promotor_-10 1098808..1098823 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1098823) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" S_feature complement(1098825..1099680) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(1098835..1098842) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1099007..1099014 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 1099026..1099045 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 1099032 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" CDS 1099077..1099655 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" gene 1099077..1099655 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" S_feature 1099656..1099801 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(1099702..1100601) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" gene complement(1099702..1100601) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" downshifts complement(1099725) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" promotor_-35 1099788..1099791 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1099803 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1099809..1099813 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1099847 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" S_feature 1099892..1100758 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(1100628..1100646) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1100645) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" promotor_-35 complement(1100661..1100667) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1100735..1100742 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1100757..1100776 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1100760 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" CDS 1100818..1101087 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" gene 1100818..1101087 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" downshifts 1101079 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" downshifts complement(1101127) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" CDS complement(1101130..1102599) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" gene complement(1101130..1102599) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" CDS complement(1102596..1102796) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" gene complement(1102596..1102796) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" S_feature complement(1102797..1102915) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(1102898..1102917) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1102915) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" promotor_-35 complement(1102930..1102937) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1103003) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" CDS complement(1103004..1103366) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" gene complement(1103004..1103366) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" promotor_-35 1103204..1103209 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1103225..1103243 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1103226 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" S_feature 1103235..1103474 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(1103396..1103415) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1103414) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" promotor_-35 complement(1103430..1103437) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1103456..1103463 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1103476 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" promotor_-10 1103477..1103496 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1103518..1104141 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" gene 1103518..1104141 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" CDS 1104143..1104649 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" gene 1104143..1104649 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" downshifts 1104642 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" promotor_-35 1104700..1104707 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1104721..1104740 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1104730..1104829 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 1104730 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" CDS 1104830..1106329 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" gene 1104830..1106329 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" promotor_-35 1106337..1106344 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1106356 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" promotor_-10 1106358..1106377 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1106406..1106933 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" gene 1106406..1106933 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" downshifts 1106895 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" S_feature complement(1106947..1107090) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" downshifts complement(1106985) /Source="Nicolas_upshifts" /id="D575" /incds=0 /nref=4 /ntot=72 /MaxReadThrough="1.20458" /MaxDrop="5.06167" /score="27.254423" /energy="-9.9" /TU="NA" /idTUdmin="U855" /TUdmin=0 /isTUend="TRUE" CDS complement(1107091..1108296) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9457850, 15849754, 16850406, 17056753, 19087206" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457850, 15849754, 16850406, 17056753, 19087206; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose/mannose:H+ symporter (recent HGT island)" /protein_id="NP_388933.1" /db_xref="EnsemblGenomes-Gn:BSU10520" /db_xref="EnsemblGenomes-Tr:CAB12892" /db_xref="GOA:O07563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13075" /db_xref="UniProtKB/Swiss-Prot:O07563" /translation="MLRGTYLFGYAFFFTVGIIHISTGSLTPFLLEAFNKTTDDISVI IFFQFTGFLSGVLIAPLMIKKYSHFRTLTLALTIMLVALSIFFLTKDWYYIIVMAFLL GYGAGTLETTVGSFVIANFESNAEKMSKLEVLFGLGALSFPLLINSFIDINNWFLPYY CIFTFLFVLFVGWLIFLSKNREYAKNANQQVTFPDGGAFQYFIGDRKKSKQLGFFVFF AFLYAGIETNFANFLPSIMINQDNEQISLISVSFFWVGIIIGRILIGFVSRRLDFSKY LLFSCSCLIVLLIAFSYISNPILQLSGTFLIGLSIAGIFPIALTLASIIIQKYVDEVT SLFIASASFGGAIISFLIGWSLNQDTILLTMGIFTTMAVILVGISVKIRRTKTEDPIS LENKASKTQ*" gene complement(1107091..1108296) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" promotor_-35 1107786..1107791 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1107808..1107826 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1107811..1108337 /Source="Nicolas_S_feature" /locus_tag="new_1125843_1126369" /HighExp="S4, S5, S6, S8, S7, S3, T5.0H, M9-stat, LBGstat, T4.0H" /AntisenseName="glcP" /AntisenseCor="-0.155079396671681" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S372" upshifts 1107812 /Source="Nicolas_upshifts" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" downshifts 1108295 /Source="Nicolas_upshifts" /id="D576" /incds=0 /nref=6 /ntot=59 /MaxReadThrough="2.40974" /MaxDrop="3.26024" /score="9.68585629" /energy="-9.4" /TU="NA" /idTUdmin="U852" /TUdmin=0 /isTUend="TRUE" CDS complement(1108368..1109420) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" /EC_number="1.1.1.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose), glucose-6-P 3-dehydrogenase; kanosamine biosynthesis (recent HGT island)" /protein_id="NP_388934.2" /db_xref="EnsemblGenomes-Gn:BSU10530" /db_xref="EnsemblGenomes-Tr:CAB12893" /db_xref="GOA:O07564" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13076" /db_xref="UniProtKB/Swiss-Prot:O07564" /translation="MKKIGIIGAGGIARAHATALSTIKNAELVGVYDINQQNAESFVK TFGGKSFENVDELIDASEGLIVASPNFCHKEHALQALGKHKHVLCEKPMAISLEEASI MKDTAERLSVRASMGFNYRYLSYVNILKSLIINNELGNILSIKVHFKKNSALRRKKFT WRDDANSKKTSGSLGDLGIHLIDMVWYLFESDFITESVRAKMNTNVKTKEDKQVLVDD YAEIYGQLKNKVFVNIITSKCSVPEDCGFSIEVVGHKKEFKYHTGNPHVYKLIDGLNV VDCPVPQSLLNDPPNEFYGWADSFRSELINWIASTQNDWVEIPSFSDGFRSQEVLEMF FEKDSNSQPMSVSAVN*" gene complement(1108368..1109420) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" CDS complement(1109434..1110282) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);kanosamine-6-phosphate phosphatase (recent HGT island)" /protein_id="NP_388935.2" /db_xref="EnsemblGenomes-Gn:BSU10540" /db_xref="EnsemblGenomes-Tr:CAB12894" /db_xref="GOA:O07565" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR006380" /db_xref="InterPro:IPR036412" /db_xref="PDB:3GYG" /db_xref="SubtiList:BG13077" /db_xref="UniProtKB/Swiss-Prot:O07565" /translation="MLLSKKSEYKTLSTVEHPQYIVFCDFDETYFPHTIDEQKQQDIY ELEDYLEQKSKDGELIIGWVTGSSIESILDKMGRGKFRYFPHFIASDLGTEITYFSEH NFGQQDNKWNSRINEGFSKEKVEKLVKQLHENHNILLNPQTQLGKSRYKHNFYYQEQD EINDKKNLLAIEKICEEYGVSVNINRCNPLAGDPEDSYDVDFIPIGTGKNEIVTFMLE KYNLNTERAIAFGDSGNDVRMLQTVGNGYLLKNATQEAKNLHNLITDSEYSKGITNTL KKLIGS*" gene complement(1109434..1110282) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" CDS complement(1110254..1111579) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" /EC_number="2.6.1.-" /function="16.5: Explore" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);3-oxo-glucose-6-phosphate:glutamate aminotransferase; kanosamine aminotransferase (recent HGT island)" /protein_id="NP_388936.1" /db_xref="EnsemblGenomes-Gn:BSU10550" /db_xref="EnsemblGenomes-Tr:CAB12895" /db_xref="GOA:O07566" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:4K2B" /db_xref="PDB:4K2I" /db_xref="PDB:4K2M" /db_xref="SubtiList:BG13078" /db_xref="UniProtKB/Swiss-Prot:O07566" /translation="MQKQVKISGKSKENMSLLKHLKGDVQGKELVIEDSIVNERWKQV LKEKIDIEHDLFNYQKNREISKVPFLPVDRLITNDEVEDILNTLTEVLPTGKFTSGPY LEQFEKVLSTYLHKRYVIATSSGTDAIMIGLLALGLNPGDEVIMPANSFSATENAVLA SGGVPIYVDINPQTFCIDPDKIEEAITPYTKFILPVHLYGKHSDMQHIRQIANRYKLK VIEDACQGIGLTDLGKYADITTLSFNPYKNFGVCGKAGAIATDNEELAKKCIQFSYHG FEVNVKNKKVINFGFNSKMDNLQAAIGLERMKYLSLNNFKRLFLADRYITQLAELQNK GYIELPELSEDHVWHLFPIKVRTEDRADIMTKLNEDFGVQTDVYYPILSHMQKTPLVQ DKYAGLQLVHTEKAHSQVLHLPLYPSFTLEEQDRVMEGLFHVIKQEIGV*" gene complement(1110254..1111579) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" promotor_-35 1110423..1110428 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-35" promotor_-10 1110444..1110462 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-10" S_feature 1110450..1111238 /Source="Nicolas_S_feature" /locus_tag="new_1128482_1129270" /HighExp="S4, S3, S5, S6, S7, T5.0H, M9-stat, S8, Pyr, G/S" /AntisenseName="ntdA" /AntisenseCor="-0.29559566742128002" /AntisenseRegPval="-6.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S373" upshifts 1110450 /Source="Nicolas_upshifts" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" promotor_-35 1111214..1111221 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1111236..1111255 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1111240..1111682 /Source="Nicolas_S_feature" /locus_tag="new_1129272_1129714" /HighExp="T4.0H, T3.0H, T2.30H, HiOs, T3.30H, T2.0H, T5.0H, T1.30H, LoTm, T-1.10H" /AntisenseName="ntdA" /AntisenseCor="-0.101471720232752" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.998, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S374" upshifts 1111240 /Source="Nicolas_upshifts" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" promotor_-10 complement(1111614..1111633) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1111626) /Source="Nicolas_upshifts" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" promotor_-35 complement(1111647..1111654) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1111683..1112672 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the ntd operon (NtdR-NTD) (recent HGT island)" /protein_id="NP_388937.1" /db_xref="EnsemblGenomes-Gn:BSU10560" /db_xref="EnsemblGenomes-Tr:CAB12896" /db_xref="GOA:O07567" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13079" /db_xref="UniProtKB/Swiss-Prot:O07567" /translation="MPTIDEIAKLCNVSKTTVSRVLNNHPYVSKEKRDMILKAINELD YTPNYLARNFRRNKTQTIALSVPSIDHPFFAQLIKGVSHEVLFKNYKVIVFQTFYDKQ TELELLELLKHKEVDGIILGTLENEWDQISPFLKYGPILLCNEYHHSADITIIGYDEF EAAYMGVVHLIERGHKKIGFCFDTPYSEAQCQRKEGYLKALQDYNLHHRSEWIFGEMF NIEDGFRVFHKIKDLKDRPSAIFTGNDQVAAGIIKQAMKNGFKVPEDLAVIGFDNQLI CQVVTPTITTIDIPVIELGQQAVLKIIESISGNASLNRRIIKLPTKLIIREST*" gene 1111683..1112672 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" S_feature 1112673..1113050 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(1112727..1112885) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(1112770) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" CDS complement(1112886..1114040) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" gene complement(1112886..1114040) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" S_feature complement(1114041..1114112) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(1114095..1114114) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1114111) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" promotor_-35 complement(1114128..1114133) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1114147..1115352) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" gene complement(1114147..1115352) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" misc_feature 1115373..1115392 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1115378 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1115466..1117193 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" gene 1115466..1117193 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" promotor_-35 1116779..1116786 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1116801..1116820 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1116808 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(1117223..1117549) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" gene complement(1117223..1117549) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" CDS complement(1117667..1118104) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" gene complement(1117667..1118104) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" downshifts complement(1117676) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" promotor_-10 complement(1118135..1118154) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1118155) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" promotor_-35 complement(1118167..1118176) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1118224..1118231 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1118245..1118264 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1118257 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" CDS 1118288..1121788 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" gene 1118288..1121788 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" CDS 1121775..1125473 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" gene 1121775..1125473 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" S_feature 1125474..1125544 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 1125545..1126720 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " gene 1125545..1126720 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" CDS 1126717..1130109 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" gene 1126717..1130109 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" promotor_-35 1129364..1129370 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1129385..1129396 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1129392 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" S_feature complement(1129461..1130434) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 1130123..1130425 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" gene 1130123..1130425 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" downshifts 1130405 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" CDS complement(1130462..1130680) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007, 20161744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007, 20161744; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388948.2" /db_xref="EnsemblGenomes-Gn:BSU10670" /db_xref="EnsemblGenomes-Tr:CAB12907" /db_xref="GOA:O06716" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13090" /db_xref="UniProtKB/Swiss-Prot:O06716" /translation="MPAIVGPIAINSISGGVVNFGDSFYLSPKSSSKSALGSGAGNTG DFLLLNNAVNATNYIDPDVNDQDMVGNG*" gene complement(1130462..1130680) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" downshifts complement(1130479) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" CDS complement(1130712..1131113) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388949.1" /db_xref="EnsemblGenomes-Gn:BSU10680" /db_xref="EnsemblGenomes-Tr:CAB12908" /db_xref="GOA:O06717" /db_xref="InterPro:IPR024496" /db_xref="SubtiList:BG13091" /db_xref="UniProtKB/Swiss-Prot:O06717" /translation="MLKRISRIRLVKFNSLGIASVFQVGDTNEIDMSVKVFAVQRSLS TFYHNEGSFNKKEYQIFQQQAVKPLPETGVQSAFCHEVPAIYVRSIKIQGVSASSVLH AGSASLIRGDARLKHIRQIQSPRSQSPAKNI*" gene complement(1130712..1131113) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" CDS complement(1131113..1131289) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388950.1" /db_xref="EnsemblGenomes-Gn:BSU10690" /db_xref="EnsemblGenomes-Tr:CAB12909" /db_xref="GOA:O06718" /db_xref="InterPro:IPR017257" /db_xref="SubtiList:BG13092" /db_xref="UniProtKB/Swiss-Prot:O06718" /translation="MIFTVINRSLEVGDIRMNGVSSSSVFHIGDTESIYLSSIFDTPP ESLIIGPFAPLAPE*" gene complement(1131113..1131289) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" CDS complement(1131286..1131903) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388951.1" /db_xref="EnsemblGenomes-Gn:BSU10700" /db_xref="EnsemblGenomes-Tr:CAB12910" /db_xref="GOA:O06719" /db_xref="InterPro:IPR019673" /db_xref="SubtiList:BG13093" /db_xref="UniProtKB/Swiss-Prot:O06719" /translation="MYDQSVSSYLQNLNSFVQQQAIHIQQLERQLKEIQTEMNTMKQR PATTIERVEYKFDQLKIERLDGTLNIGLNPTDPNSVQNFDVSQSTPQIGMMQQEESAQ LMQQIRQNVDMYLTEEIPDILEQLENQYDSRLDDTNRHHVIEDIRKQMDSRIHYYMSH IKKEENTPPAQYAEHIAEHVKRDVIRAVEHFLEHIPSEMKGDEQA*" gene complement(1131286..1131903) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" CDS complement(1131926..1132159) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388952.2" /db_xref="EnsemblGenomes-Gn:BSU10710" /db_xref="EnsemblGenomes-Tr:CAB12911" /db_xref="GOA:O06720" /db_xref="InterPro:IPR024255" /db_xref="SubtiList:BG13094" /db_xref="UniProtKB/Swiss-Prot:O06720" /translation="MNFYINQTIQINYLRLESISNSSILQIGSAGSIKSLSNLYNTGS YVEPAPEVSGSGQPLQLQEPDTGSLVPLQPPGR*" gene complement(1131926..1132159) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" CDS complement(1132174..1132395) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388953.1" /db_xref="EnsemblGenomes-Gn:BSU10720" /db_xref="EnsemblGenomes-Tr:CAB12912" /db_xref="GOA:O06721" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13095" /db_xref="UniProtKB/Swiss-Prot:O06721" /translation="MPAIVGAFKINAIGTSGVVHIGDCITISPQAQVRTFAGAGSFNT GDSLKVMNYQNATNVYDNDAVDQPIVANA*" gene complement(1132174..1132395) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" S_feature complement(1132396..1132482) /Source="Nicolas_S_feature" /locus_tag="new_1150428_1150514_c" /HighExp="S6, S8, S7, S5, BT, B36, B60, G/S, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S380" promotor_-35 1132410..1132416 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1132430..1132449 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1132432..1133087 /Source="Nicolas_S_feature" /locus_tag="new_1150464_1151119" /HighExp="Salt, BC, Sw, S8, Heat, M9-stat, S7, Etha, BMM, Lbtran" /AntisenseName="yisI" /AntisenseCor="3.97396613023396E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="0.17396" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S381" upshifts 1132432 /Source="Nicolas_upshifts" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" promotor_-10 complement(1132469..1132488) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1132482) /Source="Nicolas_upshifts" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" S_feature complement(1132484..1132613) /Source="Nicolas_S_feature" /locus_tag="new_1150516_1150645_c" /HighExp="S6, S8, S7, T5.0H, T3.30H, T4.0H, S5, T3.0H, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S382" promotor_-35 complement(1132501..1132510) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1132615..1132817) /Source="Nicolas_S_feature" /locus_tag="new_1150647_1150849_c" /HighExp="T5.0H, T4.0H, T3.30H, S6, M9-stat, T3.0H, S8, S7, T2.30H, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.976, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S383" downshifts complement(1132658) /Source="Nicolas_upshifts" /id="D581" /incds=0 /nref=13 /ntot=116 /MaxReadThrough="3.97434" /MaxDrop="3.59184" /score="13.5435041" /energy="-15.3" /TU="U865" /idTUdmin="U864" /TUdmin=0 /isTUend="TRUE" CDS complement(1132818..1132988) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase (iron-metabolism related)" /protein_id="NP_388954.1" /db_xref="EnsemblGenomes-Gn:BSU10730" /db_xref="EnsemblGenomes-Tr:CAB12913" /db_xref="GOA:O06722" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13096" /db_xref="UniProtKB/Swiss-Prot:O06722" /translation="MNSKIEEMRITLIETAQKYGMNSKETIQCSQELDILLNTRIKEE MIFGRYLENSRM*" gene complement(1132818..1132988) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" misc_feature complement(1133032..1133051) /Source="Nicolas_upshift_promotors" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1133035) /Source="Nicolas_upshifts" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" S_feature complement(1133037..1133133) /Source="Nicolas_S_feature" /locus_tag="new_1151069_1151165_c" /HighExp="S6, S8, S7, S5, BT, Pyr, G/S, Glucon, SMMPr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S384" downshifts 1133044 /Source="Nicolas_upshifts" /id="D582" /incds=0 /nref=3 /ntot=54 /MaxReadThrough="4.52913" /MaxDrop="3.35342" /score="12.6645711" /energy="-10.3" /TU="U862" /idTUdmin="U862" /TUdmin="-176" /isTUend="FALSE" S_feature 1133089..1133253 /Source="Nicolas_S_feature" /locus_tag="new_1151121_1151285" /HighExp="Salt, S8, S7, BC, Heat, H2O2, Sw, Oxctl, MG-0.2, MG-0.1" /AntisenseName="yisJ" /AntisenseCor="0.24461808844813801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S385" CDS complement(1133134..1134057) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein, CotH paralog" /protein_id="NP_388955.1" /db_xref="EnsemblGenomes-Gn:BSU10740" /db_xref="EnsemblGenomes-Tr:CAB12914" /db_xref="GOA:O06723" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG13097" /db_xref="UniProtKB/Swiss-Prot:O06723" /translation="MERVHLFFHREQLKRKGTAKGLFVTDRSVSPILLTQRDRAEKAS YEISWEKSLLGERTLFLNAEQDDPSLMRRRLAYCFFDQIGVPAPVASYSFLTINGQPE GIYLNIKNHQPAGKRSYGVKTADPRVPLSLFNNDSSAFLHEFFILIRTAGDDELAERI KLYLDVKLFFLWLIGNTCTNQGFYYTFCLNESGRLYVSPMETRSLAVQEWYEEDPLLT KGKTLSSRLLSIPAFRSQYHTLMKNVLKRSFTIERLSPLINEWHLDICQSAADDPFIK KSPFQIEKEQTNILREIEERQDFLQAHLARL*" gene complement(1133134..1134057) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" promotor_-10 complement(1134079..1134098) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-10" upshifts complement(1134090) /Source="Nicolas_upshifts" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" promotor_-35 complement(1134112..1134121) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-35" promotor_-35 1134141..1134149 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-35" promotor_-10 1134161..1134179 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-10" upshifts 1134166 /Source="Nicolas_upshifts" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" CDS 1134212..1135117 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16847875, 27215790, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16847875, 27215790, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydrolase/isomerase involved in remodelling the bacterial envelope" /protein_id="NP_388956.1" /db_xref="EnsemblGenomes-Gn:BSU10750" /db_xref="EnsemblGenomes-Tr:CAB12915" /db_xref="GOA:O06724" /db_xref="InterPro:IPR011234" /db_xref="InterPro:IPR036663" /db_xref="SubtiList:BG13098" /db_xref="UniProtKB/Swiss-Prot:O06724" /translation="MKFATGELYNRMFVGLIIDDEKIMDLQKAEKKLFELETIPGSLI ECIAEGDKFVAHARQLAEWAKKPNDELGSFMYSLSEVKLHAPIPKPSKNIICIGKNYR DHAIEMGSEADIPEHPMVFTKSPVTVTGHGDIVKSHEEVTSQLDYEGELAVVIGKSGT RISKEDAYDHVFGYTIVNDITARDLQKRHKQFFIGKSLDTTCPMGPVLVHKSSIQEPE RLKVETRVNGELRQSGSASDMIFSIPELIETLSKGMTLEAGDIIATGTPSGVGKGFTP PKFLRSGDKIDITIDPIGTLSNQIG*" gene 1134212..1135117 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" S_feature 1135118..1135198 /Source="Nicolas_S_feature" /locus_tag="new_1153150_1153230" /HighExp="S2, Lbstat, S1, Etha, SMMPr, M0t90, M40t90, LoTm, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S386" promotor_-35 1135168..1135171 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1135188..1135207 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1135200 /Source="Nicolas_upshifts" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" CDS 1135233..1135589 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27215790; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388957.1" /db_xref="EnsemblGenomes-Gn:BSU10760" /db_xref="EnsemblGenomes-Tr:CAB12916" /db_xref="GOA:O06725" /db_xref="InterPro:IPR010899" /db_xref="SubtiList:BG13099" /db_xref="UniProtKB/Swiss-Prot:O06725" /translation="MTHLHITTWVVALILLFVSYSLYSSGSAKGAKITHMILRLFYIL IILTGAELFVRFANWNGEYAGKMILGIITIGLMEMLLIRKKKEKSTGGLWVGFVIVLL LTVLLGLHLPIGFQLF*" gene 1135233..1135589 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" downshifts 1135486 /Source="Nicolas_upshifts" /id="D583" /incds=1 /nref=1 /ntot=44 /MaxReadThrough="4.28837" /MaxDrop="2.46999" /score="41.4247437" /energy="-11.7" /TU="U866,U867" /idTUdmin="U867" /TUdmin="-88" /isTUend="FALSE" downshifts 1135577 /Source="Nicolas_upshifts" /id="D584" /incds=0 /nref=17 /ntot=162 /MaxReadThrough="3.06092" /MaxDrop="3.41506" /score="41.4247437" /energy="-11.7" /TU="U866" /idTUdmin="U867" /TUdmin=3 /isTUend="TRUE" upshifts 1135710 /Source="Nicolas_upshifts" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" misc_feature 1135713..1135732 /Source="Nicolas_upshift_promotors" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1135757..1138441 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated protease" /protein_id="NP_388958.1" /db_xref="EnsemblGenomes-Gn:BSU10770" /db_xref="EnsemblGenomes-Tr:CAB12917" /db_xref="GOA:P54423" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034084" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG11846" /db_xref="UniProtKB/Swiss-Prot:P54423" /translation="MKRRKFSSVVAAVLIFALIFSLFSPGTKAAAAGAIDQAAALENG KEQTGAMKEPEQVKWYKVTPGATDIQKNSHMALTVKSDSVLNVSVYPSKEKALKDETF EMYRSFTAEDGKSEVIFPYAWSGPYYVKVEYLGEEEPEDGGTAEAAAEAKYTIGYKGT KKQPSDLEEEEACPVEMSVDQKKSGKGILDKLRSIRDEQLSQTAEGKELTSLYYKAAP FIVAKLALNKTARNEIYQDLVTLKPLFDDVSENGASSSYKVTEKDQKAINRLYDKALQ SVPSFLKEEIKKQADRLNMKQLQGKTAGAILTENNIAAKSEVQTTKVIFKVKDNKSLS SVHNEMKGFSASAQSKKDISNVKKAKKLFDNLYSFELPKDEKQNGAYTASAKRVKSAA ATLSKMSNVEFAEPVQEYKSLANDIQYPYQWPLKNNGENGGVKNADVKYEPANTLLSK RKLNDTLIAVVDTGVDSTLADLKGKVRTDLGHNFVGRNNNAMDDQGHGTHVAGIIAAQ SDNGYSMTGLNAKAKIIPVKVLDSAGSGDTEQIALGIKYAADKGAKVINLSLGGGYSR VLEFALKYAADKNVLIAAASGNDGENALSYPASSKYVMSVGATNRMDMTADFSNYGKG LDISAPGSDIPSLVPNGNVTYMSGTSMATPYAAAAAGLLFAQNPKLKRTEVEDMLKKT ADDISFESVDGGEEELYDDYGDPIEIPKTPGVDWHSGYGRLNVMKAVSAADLQLKVNK LESTQTAVRGSAKEGTLIEVMNGKKKLGSAKAGKDNAFKVNIATQKQDQVLYLKATKG DAKTSYKVVVVKGKPSGTPKVNAVKTKDTAVKGKANSKAMIRVKNKSKKVIASAKADA KGTFSVKIKKQKAGTVLYVTAVDTDKKESKEAKVVVEK*" gene 1135757..1138441 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" downshifts complement(1135925) /Source="Nicolas_upshifts" /id="D585" /incds=1 /nref=2 /ntot=155 /MaxReadThrough="0.14981" /MaxDrop="3.98572" /score="9.01750245" /energy="-8" /TU="NA" /idTUdmin="U869" /TUdmin=2563 /isTUend="FALSE" downshifts 1138433 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" CDS complement(1138472..1139059) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" gene complement(1138472..1139059) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" promotor_-10 complement(1139074..1139093) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1139093) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" promotor_-35 complement(1139109..1139111) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1139114..1139120 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1139132 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" promotor_-10 1139135..1139153 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1139138..1139204 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 1139205..1141049 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" gene 1139205..1141049 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" S_feature 1141050..1141117 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 1141074 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" CDS complement(1141179..1141658) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " gene complement(1141179..1141658) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" upshifts complement(1141678) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" promotor_-10 complement(1141682..1141700) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1141711..1141719) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1141850..1141854 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1141867 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" promotor_-10 1141869..1141888 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1141890..1142714 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" gene 1141890..1142714 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" promotor_-35 1142102..1142108 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1142123..1142141 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1142130 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 1142724..1144174 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(1142744..1144111) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" gene complement(1142744..1144111) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" promotor_-35 1144143..1144150 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1144164..1144183 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1144176 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" CDS 1144235..1145098 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" gene 1144235..1145098 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" CDS 1145116..1146129 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" gene 1145116..1146129 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" downshifts 1146112 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" promotor_-35 1146181..1146188 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1146203..1146222 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1146222..1146337 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 1146222 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" CDS 1146338..1147366 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" gene 1146338..1147366 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" downshifts 1147388 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" CDS complement(1147417..1147926) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" gene complement(1147417..1147926) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" downshifts complement(1147436) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" promotor_-10 complement(1147939..1147957) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1147955) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" promotor_-35 complement(1147969..1147977) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1147976..1148638) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" gene complement(1147976..1148638) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" promotor_-35 1148657..1148663 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1148677..1148696 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1148686 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" CDS 1148705..1150159 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" gene 1148705..1150159 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" S_feature complement(1150014..1150166) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(1150049) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" CDS complement(1150167..1150805) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" gene complement(1150167..1150805) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" S_feature complement(1150806..1150940) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 1150854..1150859 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1150875..1150893 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1150876 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" S_feature 1150886..1151010 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(1150926..1150945) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1150940) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" promotor_-35 complement(1150960..1150967) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1151011..1151817 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" gene 1151011..1151817 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" downshifts 1151810 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" CDS complement(1151845..1152444) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" gene complement(1151845..1152444) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" downshifts complement(1151864) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" CDS complement(1152441..1153610) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" gene complement(1152441..1153610) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" S_feature complement(1153611..1153722) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1153723..1154433) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" gene complement(1153723..1154433) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" promotor_-10 complement(1154477..1154496) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1154499) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" promotor_-35 complement(1154509..1154518) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1154548..1154557 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1154571..1154590 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1154582 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" CDS 1154618..1155304 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" gene 1154618..1155304 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" CDS 1155301..1156059 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" gene 1155301..1156059 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" downshifts 1156056 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" CDS complement(1156104..1156733) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" gene complement(1156104..1156733) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" promotor_-10 complement(1156767..1156785) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1156784) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" promotor_-35 complement(1156800..1156805) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1156829..1157944) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" gene complement(1156829..1157944) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" downshifts complement(1156858) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" CDS complement(1157953..1159221) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" gene complement(1157953..1159221) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" promotor_-10 complement(1159247..1159258) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1159256) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" promotor_-35 complement(1159272..1159278) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1159333..1160181) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" gene complement(1159333..1160181) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" downshifts complement(1159344) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" CDS complement(1160186..1160635) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" gene complement(1160186..1160635) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" promotor_-10 complement(1160656..1160675) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1160670) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" promotor_-35 complement(1160691..1160692) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1160725..1162563) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" gene complement(1160725..1162563) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" downshifts complement(1160752) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" downshifts complement(1162645) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" misc_RNA complement(1162653..1162770) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene complement(1162653..1162770) /gene="mswK" /locus_tag="BSU_misc_RNA_12" promotor_-10 complement(1162822..1162841) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1162836) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" promotor_-35 complement(1162856..1162863) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1162877..1163368) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" gene complement(1162877..1163368) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" promotor_-35 1163386..1163389 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1163392..1163411) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1163404..1163423 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1163405 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" upshifts complement(1163410) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" promotor_-35 complement(1163426..1163433) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1163467..1164363 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" gene 1163467..1164363 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" downshifts 1164350 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" CDS complement(1164416..1165000) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388985.1" /db_xref="EnsemblGenomes-Gn:BSU11040" /db_xref="EnsemblGenomes-Tr:CAB12944" /db_xref="GOA:O06748" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG13118" /db_xref="UniProtKB/Swiss-Prot:O06748" /translation="MKKAFLVFLSVVLVTTVFLVKQQESVAQAKQLEYSGEEIFKGFV FAQGEVGKQLPEVFNKAMTDKLNTKQAKAFANQVVADIKKEDADFFDNLKKAVYSKDA LKVDELLKKAGQIVEEKVEAAKEIAASKDDTSRVQAELVNTVDTANYFYYVSYVAAAG ALILIILAIDITPIAISDNVDREMAIRTLVDELN*" gene complement(1164416..1165000) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" downshifts complement(1164426) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" CDS complement(1164997..1165926) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11557812, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with HTTM domain" /protein_id="NP_388987.2" /db_xref="EnsemblGenomes-Gn:BSU11055" /db_xref="EnsemblGenomes-Tr:CAB12946" /db_xref="GOA:O06750" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG13120" /db_xref="UniProtKB/Swiss-Prot:O06750" /translation="MLENIKQTITRWDERNPWTNVYGLARSIIALSSLLTLLINHPSL IMKPASGISSYPACKMNLSLFCLGENNYMMLNLFRWVCIAILVLVVIGWRPRITGVLH WYVSYSLQSSLIVIDGGEQAAAVMTFLLLPITLTDPRKWHWSTRPIEGKRTLGKITAF ISYFVIRIQVAVLYFHSTVAKLSQQEWVDGTAVYYFAQEKTIGFNGFFQALTKPIVTS PFVVIPTWGTLLVQIVIFAALFAPKKHWRLILIIAVFMHEIFAVMLGLISFSIIMAGI LILYLTPIDSTIQFTYIRRLLWNKKHKKGEVSV*" gene complement(1164997..1165926) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" misc_feature complement(1165082) /Source="Nicolas_upshift_promotors" /id="U888" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.232767232767233" /psig="0.63936063936064" /xcortree=2974 /SigmaFactorBS="agtcatgctgggcctcatcagtttttcgattatcatggccgg cattttgatattgtatctcaCtcctatcgattccacgattcaatttacatatattcgc a" /listShort="yitM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1165084) /Source="Nicolas_upshifts" /id="U888" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.232767232767233" /psig="0.63936063936064" /xcortree=2974 /SigmaFactorBS="agtcatgctgggcctcatcagtttttcgattatcatggccgg cattttgatattgtatctcaCtcctatcgattccacgattcaatttacatatattcgc a" /listShort="yitM" /GFF_Attribute="listLong" CDS complement(1165911..1166447) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 6289325, 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388988.1" /db_xref="EnsemblGenomes-Gn:BSU11070" /db_xref="EnsemblGenomes-Tr:CAB12947" /db_xref="GOA:O06751" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG13121" /db_xref="UniProtKB/Swiss-Prot:O06751" /translation="MQKSISFFVIFSILWGSLFLFSIIGSLGTTPIPLTKDSKFLMSS ILPQGWGFFSKNPRDTAIGLYEAENASAKVRWPNMRADNLFGLYRYGRSQGVEMGVIY SQVGKEQWTACKEKDLGACKSKAKTVQLKTPAPRPLLCGSYYLTKEDIVPWSYSKYTP SSYQVKSIVKVVISCSKT*" gene complement(1165911..1166447) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" promotor_-10 complement(1166483..1166502) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1166497) /Source="Nicolas_upshifts" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" promotor_-35 complement(1166517..1166520) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1166588..1166595 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1166610..1166629 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1166613 /Source="Nicolas_upshifts" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" CDS 1166625..1166972 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097701.1" /db_xref="EnsemblGenomes-Gn:BSU11079" /db_xref="EnsemblGenomes-Tr:CAX52589" /db_xref="GOA:C0H3Y4" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Y4" /translation="MKTNQVNDRWIVQFRKGIFELAILSLLRSKPMYGYELTSSLKTT SALAISEGAIYPILKRMTEKGWIEFFWEDSLDGPKRKYYKMTQKGEEMLKERLEKYLE THQALLSLSGDLL*" gene 1166625..1166972 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" CDS 1166969..1167556 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23504016" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388989.2" /db_xref="EnsemblGenomes-Gn:BSU11080" /db_xref="EnsemblGenomes-Tr:CAB12948" /db_xref="GOA:O06752" /db_xref="SubtiList:BG13122" /db_xref="UniProtKB/Swiss-Prot:O06752" /translation="MNGQLIIDRYMEELNAELANMPDVERENAIDELKGHITAFVQDR IKAGLSEEELQEAVESEFSHPKELAELMMGDGGETKRRRSLLGKSWISVLLIVTIIAL PLLPSDFRHLPLAVYLMVLAGYVWKRKKLVMFAGVRKNKMRSQKEIVKISRVGAVYLL FLAVVLLLSPFLNALVVLLLIAVSCAAFFLFLNIK*" gene 1166969..1167556 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" CDS 1167576..1167869 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388990.1" /db_xref="EnsemblGenomes-Gn:BSU11090" /db_xref="EnsemblGenomes-Tr:CAB12949" /db_xref="GOA:O06753" /db_xref="InterPro:IPR017259" /db_xref="SubtiList:BG13123" /db_xref="UniProtKB/Swiss-Prot:O06753" /translation="MEISINYLLIVIALLFFVVAYFVGIKKQTWMLAGFNEARIRDKD RLARIAGYFFLNSGLFILLNSFISFQGQEQLIPPLILAYGAGVIIYVNKKLVE*" gene 1167576..1167869 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" downshifts 1167849 /Source="Nicolas_upshifts" /id="D601" /incds=0 /nref=119 /ntot=240 /MaxReadThrough="1.96008" /MaxDrop="5.72545" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=0 /isTUend="TRUE" downshifts 1167893 /Source="Nicolas_upshifts" /id="D602" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="0.34732" /MaxDrop="3.0285" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=44 /isTUend="FALSE" CDS 1168005..1169621 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1917867, 16672610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1917867, 16672610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral protease B" /protein_id="NP_388991.1" /db_xref="EnsemblGenomes-Gn:BSU11100" /db_xref="EnsemblGenomes-Tr:CAB12950" /db_xref="GOA:P39899" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10691" /db_xref="UniProtKB/Swiss-Prot:P39899" /translation="MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYI IEKSPQKPVQNTTQKESLFSYLDKHQTQFKLKGNANSHFRVSKTIKDPKTKQTFFKLT EVYKGIPIYGFEQAVAMKENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEA SIGKIEYLDGEPKGELYIYPHDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESF NAIHEAAGTGIGVSGDEKSFDVTEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQ LIGYTGKEIVSGTSVFNEPAAVDAHANAQAVYDYYSKTFGRDSFDQNGARITSTVHVG KQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALN ESISDIMGAMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSNRYTGTEDYG GVHINSSIHNKAAYLLAEGGVHHGVQVEGIGREASEQIYYRALTYYVTASTDFSMMKQ AAIEAANDLYGEGSKQSASVEKAYEAVGIL*" gene 1168005..1169621 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" downshifts 1169609 /Source="Nicolas_upshifts" /id="D603" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="0.278770000000001" /MaxDrop="3.08544" /score="2.81939887" /energy="-8.6" /TU="NA" /idTUdmin="U890" /TUdmin=1760 /isTUend="FALSE" CDS complement(1169668..1170519) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit B" /protein_id="NP_388992.1" /db_xref="EnsemblGenomes-Gn:BSU11110" /db_xref="EnsemblGenomes-Tr:CAB12951" /db_xref="GOA:P70945" /db_xref="InterPro:IPR003797" /db_xref="SubtiList:BG12244" /db_xref="UniProtKB/Swiss-Prot:P70945" /translation="MTVHLIADSATDLPRSYFEEKGIGFIPLRVSLGDKEFEDAVTIH ADQIFEAMQNGETPKTSQASPQTIKNVFLQYAETGDPALYIAFSSGLSGTYQTAVMIA NEVKEEFPDFDLRVIDSKCASLGYGLAVRHAADLCINGNTIQEIETSVKNFCSQLEHI FTVDDLTYLARGGRISKTSAFVGGLLNIKPLLQMEDGKLVPLEKIRGQKKLFKRIIEL MKERGDDWSNQTVGISYAANKEKATDMKHLIEEAFKPKEIIMHPISSAIGSHAGPGTL AIFFLRK*" gene complement(1169668..1170519) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" downshifts complement(1169685) /Source="Nicolas_upshifts" /id="D604" /incds=0 /nref=209 /ntot=263 /MaxReadThrough="0.727580000000001" /MaxDrop="6.86927" /score="-1.24586831" /energy="-7.7" /TU="NA" /idTUdmin="U892" /TUdmin=0 /isTUend="TRUE" promotor_-35 1170066..1170073 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1170088..1170107 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1170093..1170618 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" upshifts 1170095 /Source="Nicolas_upshifts" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" promotor_-10 complement(1170560..1170579) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1170583) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" promotor_-35 1170597..1170602 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1170599) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1170617..1170635 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1170620 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" CDS 1170657..1171499 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" gene 1170657..1171499 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" promotor_-35 1171152..1171160 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1171171..1171189 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1171171 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" S_feature 1171500..1171613 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1171614..1171973 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" gene 1171614..1171973 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" downshifts 1171962 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" CDS complement(1172004..1172201) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" gene complement(1172004..1172201) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" downshifts complement(1172017) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" S_feature complement(1172202..1172398) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1172398) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" promotor_-10 complement(1172400..1172411) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1172426..1172432) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1172458..1173270) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" gene complement(1172458..1173270) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" promotor_-10 complement(1173308..1173327) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1173328..1173335 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1173328) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" promotor_-35 complement(1173341..1173348) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1173347..1173366 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1173349 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" CDS 1173391..1174158 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" gene 1173391..1174158 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" promotor_-35 1174167..1174173 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1174187 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" promotor_-10 1174188..1174207 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1174222..1174530 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" gene 1174222..1174530 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" downshifts 1174515 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" S_feature 1174560..1174825 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1174826..1176256 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" gene 1174826..1176256 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" CDS 1176301..1176795 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" gene 1176301..1176795 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" downshifts 1176759 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" promotor_-35 1176933..1176940 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1176939 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" promotor_-10 1176954..1176973 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1177002..1178039 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" gene 1177002..1178039 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" CDS 1178059..1179279 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" gene 1178059..1179279 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" CDS 1179294..1180070 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" gene 1179294..1180070 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" CDS 1180067..1181224 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" gene 1180067..1181224 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" CDS 1181295..1182356 /gene="carA" /locus_tag="BSU_11230" /old_locus_tag="BSU11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGIVLSNGPGDPKAIQ PYLGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMT SQNHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEW IFDDYLKNVIPARREIAHA*" gene 1181295..1182356 /gene="carA" /locus_tag="BSU_11230" /old_locus_tag="BSU11230" misc_feature complement(1182190..1182209) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1182200) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1182349..1185441 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" gene 1182349..1185441 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" CDS 1185429..1186388 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" gene 1185429..1186388 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" downshifts 1186351 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" S_feature complement(1186391..1186665) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1186416..1186422 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1186424) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" promotor_-10 1186437..1186448 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1186458 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" CDS 1186474..1186653 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" gene 1186474..1186653 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" downshifts 1186663 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" CDS complement(1186699..1186884) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" gene complement(1186699..1186884) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" downshifts complement(1186710) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" promotor_-10 complement(1186913..1186932) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1186930) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" promotor_-35 complement(1186943..1186950) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1186985..1186991 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1187003..1187022 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1187008 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1187065..1187074 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1187074 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" promotor_-10 1187087..1187106 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1187133..1187867 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" gene 1187133..1187867 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" S_feature complement(1187626..1188228) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1187848..1187853 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1187866 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" upshifts 1187866 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" promotor_-10 1187869..1187887 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1187949..1188506 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" gene 1187949..1188506 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" promotor_-10 complement(1188208..1188227) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1188228) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" promotor_-35 complement(1188242..1188246) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1188513..1188520 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1188535..1188554 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1188547 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" CDS 1188597..1189550 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" gene 1188597..1189550 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" promotor_-35 1189214..1189218 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1189234..1189253 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1189247 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" CDS 1189565..1189756 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" gene 1189565..1189756 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" downshifts 1189735 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" S_feature 1189780..1190120 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1189786..1190025) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" gene complement(1189786..1190025) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" downshifts complement(1189802) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" promotor_-10 complement(1190038..1190057) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1190059) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" promotor_-35 complement(1190071..1190080) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1190086..1190093 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1190108..1190127 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1190122 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" CDS 1190190..1191128 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" gene 1190190..1191128 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" promotor_-35 1190267..1190276 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1190285 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" promotor_-10 1190288..1190303 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1191151..1192392 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" gene 1191151..1192392 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" promotor_-10 complement(1191365..1191383) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1191373) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1191399..1191404) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1192243 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" downshifts 1192376 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" promotor_-35 1192417..1192426 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1192439..1192458 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1192441 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" promotor_-35 1192453..1192461 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1192468..1193253 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" gene 1192468..1193253 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" promotor_-10 1192473..1192491 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1192485 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 1193254..1193338 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1193270..1193288) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1193287) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1193303..1193308) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1193306..1193313 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1193328..1193347 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1193340..1193444 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1193340 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" CDS 1193445..1194431 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" gene 1193445..1194431 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" CDS 1194428..1195417 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" gene 1194428..1195417 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" misc_feature 1195423..1195429 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1195428..1195504 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1195428 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" CDS 1195505..1195996 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" gene 1195505..1195996 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo CDS 1195969..1197135 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" gene 1195969..1197135 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo downshifts 1197126 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" CDS 1197211..1198161 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" gene 1197211..1198161 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" CDS 1198178..1199089 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" gene 1198178..1199089 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" downshifts 1199103 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" S_feature 1199148..1199255 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1199228..1199233 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1199249..1199267 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1199257 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" CDS 1199294..1200046 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" gene 1199294..1200046 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" downshifts 1200026 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" CDS complement(1200081..1201073) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" gene complement(1200081..1201073) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" downshifts complement(1200102) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" misc_RNA complement(1201132..1201346) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" gene complement(1201132..1201346) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" downshifts complement(1201180) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" misc_feature complement(1201365..1201384) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1201378) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" promotor_-35 1201633..1201640 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1201654..1201816 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1201655..1201674 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1201655 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" CDS 1201817..1203454 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" gene 1201817..1203454 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" downshifts 1203348 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" S_feature 1203455..1203561 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1203562..1204497 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" gene 1203562..1204497 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" promotor_-10 complement(1203605..1203624) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1203622) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1203640..1203646) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1204501..1205418 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" gene 1204501..1205418 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" CDS 1205423..1206499 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" gene 1205423..1206499 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" CDS 1206501..1207418 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" gene 1206501..1207418 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" downshifts 1207388 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" promotor_-35 1207468..1207471 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1207484 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1207486..1207505 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1207525..1208742 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" gene 1207525..1208742 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" promotor_-35 1208795..1208804 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1208817..1208832 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1208826..1208905 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1208826 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" CDS 1208906..1209484 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" gene 1208906..1209484 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" S_feature 1209485..1209599 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1209536..1209555) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1209540) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1209569..1209576) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1209602..1209615 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1209602 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" CDS 1209665..1210060 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" gene 1209665..1210060 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" promotor_no_box complement(1209896..1209996) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1209936) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1210058 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" S_feature 1210103..1210892 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1210103..1210759) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" gene complement(1210103..1210759) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" promotor_-10 complement(1210789..1210807) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1210804) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" promotor_-35 complement(1210822..1210827) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1210865..1210872 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1210886..1210905 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1210894..1211035 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1210894 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" CDS 1210929..1211069 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" gene 1210929..1211069 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" CDS 1211036..1211692 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" gene 1211036..1211692 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" downshifts 1211682 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" CDS complement(1211687..1211809) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" gene complement(1211687..1211809) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" S_feature 1211727..1211816 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1211795..1211803 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1211814..1211832 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1211818..1211882 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1211818 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" CDS 1211883..1213004 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" gene 1211883..1213004 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" promotor_-35 1212658..1212664 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1212676 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" promotor_-10 1212679..1212697 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1212890..1212898 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1212910..1212928 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1212917 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" promotor_-35 1212998..1213004 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1213019..1213030 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1213028 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" CDS 1213051..1215063 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" gene 1213051..1215063 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" promotor_-35 1213126..1213133 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1213148..1213167 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1213160 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" downshifts 1215010 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" S_feature 1215064..1215365 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1215101..1215268) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" gene complement(1215101..1215268) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" downshifts complement(1215114) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" promotor_-10 complement(1215288..1215306) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1215304) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" promotor_-35 complement(1215322..1215327) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1215358..1215365 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1215367..1215492 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1215367 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" misc_RNA 1215373..1215511 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" gene 1215373..1215511 /gene="roxS" /locus_tag="BSU_misc_RNA_67" promotor_-10 1215380..1215399 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1215449 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" CDS complement(1215582..1216481) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" gene complement(1215582..1216481) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" downshifts complement(1215613) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" promotor_-35 1215817..1215822 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1215829 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" promotor_-10 1215838..1215856 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1215845..1217746 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1216478..1216876) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" gene complement(1216478..1216876) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" S_feature complement(1216877..1217056) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1217048..1217067) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1217056) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" promotor_-35 complement(1217079..1217086) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1217131..1217676) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" gene complement(1217131..1217676) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" downshifts complement(1217155) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" S_feature complement(1217677..1217879) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1217880..1218452) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" gene complement(1217880..1218452) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" promotor_-10 complement(1218025..1218043) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1218034) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" promotor_-35 complement(1218056..1218063) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1218481..1218500) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1218498) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" promotor_-35 1218514..1218517 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1218515..1218522) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1218530 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" promotor_-10 1218533..1218552 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1218577..1218945 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" gene 1218577..1218945 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" CDS 1218974..1219609 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" gene 1218974..1219609 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" CDS 1219628..1220428 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" gene 1219628..1220428 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" CDS 1220491..1221342 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" gene 1220491..1221342 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" downshifts 1221301 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" CDS complement(1221355..1222089) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" gene complement(1221355..1222089) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" downshifts complement(1221377) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" promotor_-35 1222211..1222215 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1222232..1222251 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1222246 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" S_feature 1222247..1222323 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1222324..1224168 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" gene 1222324..1224168 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" misc_feature complement(1222651..1222670) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1222675) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1224170..1224177 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1224191..1224210 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1224197 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" misc_RNA 1224230..1224338 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene 1224230..1224338 /gene="tswA" /locus_tag="BSU_misc_RNA_14" downshifts 1224333 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" CDS 1224417..1225127 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" gene 1224417..1225127 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" CDS 1225102..1225719 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" gene 1225102..1225719 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" CDS 1225703..1226812 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" gene 1225703..1226812 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" CDS 1226812..1227012 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" gene 1226812..1227012 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" CDS 1227009..1227779 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" gene 1227009..1227779 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" CDS 1227776..1228786 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" gene 1227776..1228786 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" CDS 1228805..1229620 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" gene 1228805..1229620 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" downshifts 1229594 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" promotor_-35 1229667..1229673 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1229686..1229705 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1229696 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" CDS 1229756..1230532 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" gene 1229756..1230532 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" downshifts 1230521 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" promotor_-35 1230580..1230585 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1230601..1230619 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1230605 /Source="Nicolas_upshifts" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" promotor_-10 complement(1230617..1230631) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1230617) /Source="Nicolas_upshifts" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1230633..1231316 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outer coat protein" /protein_id="NP_389055.1" /db_xref="EnsemblGenomes-Gn:BSU11730" /db_xref="EnsemblGenomes-Tr:CAB13030" /db_xref="GOA:O31622" /db_xref="InterPro:IPR025439" /db_xref="SubtiList:BG13153" /db_xref="UniProtKB/Swiss-Prot:O31622" /translation="MKMSNKKRNADKKPLMYIVQPDYAETTRSSMQEIVIKRKADKPA PPKAEEKPAYHEKQQEEAVAQDVLQEDQKPAAEPVSQQTQEAREPENIKSQEEQKAEP QAVEETVEHEPPKAEKKEEPALEARKPEKEPEAVHSADKAEEKAPPARKVKKPMSKMT IHEKIDFLTKLPHNMPRALCLIEANGRTYRGVIVGRRNDSVLLRTTGNGAPTELAIDD ITSLHPLGF*" gene 1230633..1231316 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" promotor_-35 complement(1230639..1230643) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1231311 /Source="Nicolas_upshifts" /id="D637" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="3.37645" /MaxDrop="4.6587" /score="18.0229289" /energy="-13.4" /TU="U945" /idTUdmin="U945" /TUdmin="-66" /isTUend="FALSE" downshifts 1231399 /Source="Nicolas_upshifts" /id="D638" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.44926" /MaxDrop="4.55934" /score="18.0229289" /energy="-13.4" /TU="NA" /idTUdmin="U945" /TUdmin=22 /isTUend="TRUE" CDS complement(1231410..1231856) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 19933362, 26341943, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 19933362, 26341943, 27320701; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction, crust layer)" /protein_id="NP_389056.1" /db_xref="EnsemblGenomes-Gn:BSU11740" /db_xref="EnsemblGenomes-Tr:CAB13031" /db_xref="GOA:Q08312" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10499" /db_xref="UniProtKB/Swiss-Prot:Q08312" /translation="MSQKTSSCVREAVENIEDLQNAVEEDCPTGCHSKLLSVSHSLGD TVPFAIFTSKSTPLVAFGNVGELDNGPCFNTVFFRVERVHGSCATLSLLIAFDEHKHI LDFTDKDTVCEVFRLEKTNYCIEVDLDCFCAINCLNPRLINRTHHH*" gene complement(1231410..1231856) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" downshifts complement(1231431) /Source="Nicolas_upshifts" /id="D639" /incds=0 /nref=7 /ntot=50 /MaxReadThrough="8.44444" /MaxDrop="7.17581" /score="2.03943557" /energy="-9.3" /TU="U949" /idTUdmin="U950" /TUdmin=0 /isTUend="TRUE" S_feature complement(1231857..1231983) /Source="Nicolas_S_feature" /locus_tag="new_1249889_1250015_c" /HighExp="S8, S7, S6, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigEF" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S420" CDS complement(1231984..1232472) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 14766913, 26341943, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 14766913, 26341943, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="outer spore coat protein (crust layer, insolublefraction)" /protein_id="NP_389057.1" /db_xref="EnsemblGenomes-Gn:BSU11750" /db_xref="EnsemblGenomes-Tr:CAB13032" /db_xref="GOA:Q08311" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10498" /db_xref="UniProtKB/Swiss-Prot:Q08311" /translation="MSCGKTHGRHENCVCDAVEKILAEQEAVEEQCPTGCYTNLLNPT IAGKDTIPFLVFDKKGGLFSTFGNVGGFVDDMQCFESIFFRVEKLCDCCATLSILRPV DVKGDTLSVCHPCDPDFFGLEKTDFCIEVDLGCFCAIQCLSPELVDRTSPHKDKKHHH NG*" gene complement(1231984..1232472) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" promotor_-35 1232152..1232158 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1232173..1232192 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1232191 /Source="Nicolas_upshifts" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1232468..1232472 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1232481..1232495 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1232499 /Source="Nicolas_upshifts" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1232509..1232528) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1232526) /Source="Nicolas_upshifts" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" promotor_-35 complement(1232542..1232551) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1232558..1232576) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1232575) /Source="Nicolas_upshifts" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" promotor_-35 complement(1232592..1232597) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1232609 /Source="Nicolas_upshifts" /id="D640" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.28604" /MaxDrop="4.18677" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=22 /isTUend="TRUE" CDS complement(1232624..1233142) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389058.1" /db_xref="EnsemblGenomes-Gn:BSU11760" /db_xref="EnsemblGenomes-Tr:CAB13033" /db_xref="GOA:Q08313" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10500" /db_xref="UniProtKB/Swiss-Prot:Q08313" /translation="MESRPYSWVALDPDCDHPLDDKEKDKEKHERKCHCDVCCNGNGF FGNDNAFIDQDLAQANLNKQVSDETIIIRDSCDINVTSTDVQAVTSVVTALNAAVVTA TLTSIADGVIAELVAQDLLQLTANKQVNRQKLLIECSRGVNVTTVDADIATLISTATN TLVAILVITLVL*" gene complement(1232624..1233142) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" downshifts complement(1232648) /Source="Nicolas_upshifts" /id="D641" /incds=0 /nref=76 /ntot=102 /MaxReadThrough="1.79219" /MaxDrop="8.69761" /score="18.5755652" /energy="-10.4" /TU="U952" /idTUdmin="U952" /TUdmin="-29" /isTUend="FALSE" downshifts 1232653 /Source="Nicolas_upshifts" /id="D642" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.2156" /MaxDrop="3.69222" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=66 /isTUend="FALSE" S_feature complement(1233143..1233240) /Source="Nicolas_S_feature" /locus_tag="new_1251175_1251272_c" /HighExp="S8, S7, S6, BT, B36, G/S, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.748" /TUlongSig="SigK" /TUlongPSig="0.98" /label="S421" CDS complement(1233241..1233558) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8509331, 19304857, 21665972, 25872412" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509331, 19304857, 21665972, 25872412; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (outemost layer)" /protein_id="NP_389059.1" /db_xref="EnsemblGenomes-Gn:BSU11770" /db_xref="EnsemblGenomes-Tr:CAB13034" /db_xref="GOA:Q08310" /db_xref="SubtiList:BG10497" /db_xref="UniProtKB/Swiss-Prot:Q08310" /translation="MSDNDKFKEELAKLPEVDPMTKMLVQNIFSKHGVTKDKMKKVSD EEKEMLLNLVKDLQAKSQALIENQKKKKEEAAAQEQKNTKPLSRREQLIEQIRQRRKN DNN*" gene complement(1233241..1233558) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" CDS complement(1233599..1233985) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389060.1" /db_xref="EnsemblGenomes-Gn:BSU11780" /db_xref="EnsemblGenomes-Tr:CAB13035" /db_xref="GOA:Q08309" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10496" /db_xref="UniProtKB/Swiss-Prot:Q08309" /translation="MSFEEKVESLHPAIFEQLSSEFEQQIEVIDCENITIDTSHITAA LSIQAFVTTMIIVATQLVIADEDLADAVASEILILDSSQIKKRTIIKIINSRNIKITL SADEIITFVQILLQVLNSILSELDVL*" gene complement(1233599..1233985) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" promotor_-35 1233981..1233985 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1233993..1234007 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1233995 /Source="Nicolas_upshifts" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1234005..1234024) /Source="Nicolas_upshift_promotors" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1234027) /Source="Nicolas_upshifts" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" S_feature complement(1234029..1234533) /Source="Nicolas_S_feature" /locus_tag="new_1252061_1252565_c" /HighExp="S8, S6, S7, BT, S5, B36, Pyr, C30, G/S, nit" /AntisenseName="yjcA" /AntisenseCor="0.69838474492609404" /AntisenseRegPval="-39.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S422" promotor_-35 complement(1234043) /Source="Nicolas_upshift_promotors" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1234082..1234087 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 1234103..1234121 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1234105 /Source="Nicolas_upshifts" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" CDS 1234145..1234501 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="NP_389061.1" /db_xref="EnsemblGenomes-Gn:BSU11790" /db_xref="EnsemblGenomes-Tr:CAB13036" /db_xref="GOA:O31623" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13154" /db_xref="UniProtKB/Swiss-Prot:O31623" /translation="MVINGLTIVLLSLAVFRLARLLVFDTIMAPLRSLFHEEKEEKDA DGNIETYIVIKGTGVRAFIGELLSCYWCTGVWCAGFLILCQAVIPQAAQWLILLLAIA GLAGIIETLVSKWLQE*" gene 1234145..1234501 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" promotor_-35 1234511..1234520 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 complement(1234518..1234537) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-10" CDS complement(1234526..1234759) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="protein remnant" /db_xref="PSEUDO:SOX90549.1" /translation="MLSETASLKKQKTGVLRFLCQAIEAFSFYFRTRSLSFLSFLIDT MNLYMEIFGKVYDADSFLSPSFPYVIYATLCVF*" gene complement(1234526..1234759) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /pseudo upshifts complement(1234533) /Source="Nicolas_upshifts" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" S_feature 1234534..1234720 /Source="Nicolas_S_feature" /locus_tag="new_1252566_1252752" /HighExp="S8, S6, S7, BT, S5, B36, S4, S3, G/S, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.26970100000000002" /TUshortSig="SigK, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S423" promotor_-10 1234534..1234551 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1234534 /Source="Nicolas_upshifts" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" promotor_-35 complement(1234551..1234560) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-35" downshifts complement(1234577) /Source="Nicolas_upshifts" /id="D643" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.12564" /MaxDrop="4.58782" /score="-6.14331629" /energy="-6.8" /TU="NA" /idTUdmin="U954" /TUdmin="-528" /isTUend="FALSE" downshifts 1234677 /Source="Nicolas_upshifts" /id="D644" /incds=0 /nref=3 /ntot=32 /MaxReadThrough="5.73879" /MaxDrop="3.6919" /score="33.8150878" /energy="-6.8" /TU="U953,U955" /idTUdmin="U953" /TUdmin="-66" /isTUend="FALSE" upshifts complement(1234731) /Source="Nicolas_upshifts" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1234732..1234741 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1234739..1234746) /Source="Nicolas_upshift_promotors" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1234755..1234774 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1234765 /Source="Nicolas_upshifts" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" CDS 1234783..1234989 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097704.1" /db_xref="EnsemblGenomes-Gn:BSU11799" /db_xref="EnsemblGenomes-Tr:CAX52594" /db_xref="UniProtKB/Swiss-Prot:C0H3Y7" /translation="MNEFEKWIEGRYEPHEQKQKEHEDTMGSIRKDLDAFDKAGLEFE DEIEELAEKTEALLKKHQAQYDQS*" gene 1234783..1234989 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" CDS 1234826..1235041 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="YP_009513951.1" /translation="MNKSKKSMKTRWAVSEKTWMHLIKPVWNLKMRLKSWLKKRRPYL KNIKLNMINRKSANALCEYPSRSQQLT*" gene 1234826..1235041 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" promotor_-35 1235013..1235022 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1235035..1235054 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1235040 /Source="Nicolas_upshifts" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" promotor_-10 complement(1235047..1235061) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1235061) /Source="Nicolas_upshifts" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1235071..1235075) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1235071..1235220 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523132, 20156992, 21670523; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097705.1" /db_xref="EnsemblGenomes-Gn:BSU11809" /db_xref="EnsemblGenomes-Tr:CAX52595" /db_xref="GOA:C0H3Y8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y8" /translation="MGFGYGFGGGYGGGCYGGYAGGYGGGYGSTFVLLVVLFILLIIV GASFF*" gene 1235071..1235220 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" downshifts 1235161 /Source="Nicolas_upshifts" /id="D645" /incds=0 /nref=4 /ntot=29 /MaxReadThrough="8.16203" /MaxDrop="4.48861" /score="1.53429015" /energy="-22.4" /TU="U957,U958" /idTUdmin="U955" /TUdmin=110 /isTUend="FALSE" S_feature 1235221..1235352 /Source="Nicolas_S_feature" /locus_tag="new_1253253_1253384" /HighExp="S7, BT, S8, B36, S6, G/S, Pyr, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S424" CDS 1235353..1235607 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 14702409, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 14702409, 20435725; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein needed for heat resistance" /protein_id="NP_389063.2" /db_xref="EnsemblGenomes-Gn:BSU11810" /db_xref="EnsemblGenomes-Tr:CAB13038" /db_xref="GOA:O31625" /db_xref="InterPro:IPR025942" /db_xref="SubtiList:BG13156" /db_xref="UniProtKB/Swiss-Prot:O31625" /translation="MDNQFFKNIEKKTGVKMQDVMNLAGSLQNANFKDENTVRSVINR VAQMANRRVPKELEDKIVESITSGKEKLDFGTISKMMDNK*" gene 1235353..1235607 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" downshifts 1235592 /Source="Nicolas_upshifts" /id="D646" /incds=0 /nref=40 /ntot=79 /MaxReadThrough="5.66609" /MaxDrop="5.8411" /score="7.68851688" /energy="-10.7" /TU="U957,U958" /idTUdmin="U955" /TUdmin=541 /isTUend="FALSE" downshifts complement(1235611) /Source="Nicolas_upshifts" /id="D647" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="3.12148" /MaxDrop="4.34051" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=88 /isTUend="FALSE" S_feature 1235637..1236737 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1235681..1237960) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" gene complement(1235681..1237960) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" downshifts complement(1235699) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" S_feature complement(1237835..1238009) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1237888..1237896 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1237907..1237925 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1237911..1238046 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1237911 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" promotor_-10 complement(1237997..1238016) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1238008) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" promotor_-35 1238024..1238030 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1238032..1238036) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1238045..1238063 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1238048 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" CDS 1238077..1238331 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" gene 1238077..1238331 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" downshifts 1238307 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" downshifts complement(1238397) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" CDS complement(1238404..1238826) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" gene complement(1238404..1238826) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" CDS complement(1238830..1239345) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" gene complement(1238830..1239345) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" CDS complement(1239382..1240104) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" gene complement(1239382..1240104) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" misc_feature complement(1240143..1240162) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1240164) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" promotor_-35 1240213..1240220 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1240235..1240254 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1240239 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" misc_RNA 1240272..1240392 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene 1240272..1240392 /gene="mswA" /locus_tag="BSU_misc_RNA_15" downshifts 1240397 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" CDS 1240460..1241581 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" gene 1240460..1241581 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" CDS 1241574..1242746 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" gene 1241574..1242746 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" downshifts 1242729 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" misc_feature 1242763..1242781 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1242773 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" S_feature 1242774..1244303 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1242779..1243324) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" gene complement(1242779..1243324) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" downshifts complement(1242800) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" CDS complement(1243394..1244584) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" gene complement(1243394..1244584) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" promotor_-10 complement(1244610..1244629) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1244614) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" promotor_-35 complement(1244644..1244651) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1244678..1244685 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1244689 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" promotor_-10 1244699..1244718 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1244757..1244829 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 1244757..1244829 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" promotor_-10 complement(1244771..1244788) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1244785) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1244809..1244815) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1244819 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" S_feature complement(1244844..1245579) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1244864..1246512 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1244873) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" S_feature complement(1245581..1245669) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1245624) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" CDS complement(1245670..1246899) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" gene complement(1245670..1246899) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" downshifts complement(1245792) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" downshifts 1246469 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" S_feature complement(1246900..1246985) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1246940..1246947 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1246962..1246981 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1246971..1246990) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1246975 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" upshifts complement(1246989) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" promotor_-35 complement(1247003..1247009) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1247025..1247345 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" gene 1247025..1247345 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" downshifts 1247355 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" S_feature 1247400..1247497 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1247498..1247629 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " gene 1247498..1247629 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" CDS 1247645..1247818 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" gene 1247645..1247818 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" CDS 1247855..1248316 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" gene 1247855..1248316 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" promotor_-35 1248287..1248294 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1248309..1248328 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1248317..1248557 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1248317 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" promotor_-35 1248530..1248537 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1248551..1248569 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1248559 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" CDS 1248582..1249085 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" gene 1248582..1249085 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" CDS 1249097..1249381 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" gene 1249097..1249381 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" downshifts 1249351 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" upshifts complement(1249383) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1249394..1249397) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1249542..1250069 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" gene 1249542..1250069 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" promotor_-35 1250216..1250221 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1250234..1250253 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1250237 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" CDS 1250243..1250560 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" gene 1250243..1250560 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" S_feature 1250561..1250796 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1250797..1251552 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" gene 1250797..1251552 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" S_feature 1251553..1251640 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1251597 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" S_feature complement(1251640..1251700) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1251671) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" CDS complement(1251701..1252048) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" gene complement(1251701..1252048) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" promotor_-10 complement(1252080..1252098) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1252093) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" S_feature complement(1252095..1252551) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1252109..1252117) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1252511..1252529 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1252523 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" promotor_-10 complement(1252529..1252548) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1252551) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" promotor_-35 complement(1252562..1252569) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1252599..1254545 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" gene 1252599..1254545 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" downshifts 1254521 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" promotor_-35 1254621..1254624 /Source="Nicolas_upshift_promotors" /id="U978" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.936063936063936" /xcortree=1565 /SigmaFactorBS="tttattaccggaacctatggtaaaaaaagcGATTttaatgag ctgatttCGGTATACAGTTGAGACAAGatcttattattcacactttaaaggaggtttc c" /listShort="manP, manA, S439, S440, yjdF, yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1254640..1254659 /Source="Nicolas_upshift_promotors" /id="U978" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.936063936063936" /xcortree=1565 /SigmaFactorBS="tttattaccggaacctatggtaaaaaaagcGATTttaatgag ctgatttCGGTATACAGTTGAGACAAGatcttattattcacactttaaaggaggtttc c" /listShort="manP, manA, S439, S440, yjdF, yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1254651 /Source="Nicolas_upshifts" /id="U978" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.936063936063936" /xcortree=1565 /SigmaFactorBS="tttattaccggaacctatggtaaaaaaagcGATTttaatgag ctgatttCGGTATACAGTTGAGACAAGatcttattattcacactttaaaggaggtttc c" /listShort="manP, manA, S439, S440, yjdF, yjdI" /GFF_Attribute="listLong" upshifts complement(1254663) /Source="Nicolas_upshifts" /id="U979" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.748251748251748" /psig="0.14985014985015" /xcortree=304 /SigmaFactorBS="tcggacaagatgtaatcgctaacagtttcataggaaaCCTCC TTTAAAGTGTgaataataagatcttgtctcaactgtataccgaaatcagctcattaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1254672..1254686) /Source="Nicolas_upshift_promotors" /id="U979" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.748251748251748" /psig="0.14985014985015" /xcortree=304 /SigmaFactorBS="tcggacaagatgtaatcgctaacagtttcataggaaaCCTCC TTTAAAGTGTgaataataagatcttgtctcaactgtataccgaaatcagctcattaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1254693..1256645 /gene="manP" /locus_tag="BSU_12010" /old_locus_tag="BSU12010" /EC_number="2.7.1.191" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10627040, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627040, 10960106, 23551403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannose-specificenzyme IIBCA component" /protein_id="NP_389083.2" /db_xref="EnsemblGenomes-Gn:BSU12010" /db_xref="EnsemblGenomes-Tr:CAB13058" /db_xref="GOA:O31645" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R48" /db_xref="SubtiList:BG13176" /db_xref="UniProtKB/Swiss-Prot:O31645" /translation="MKLLAITSCPNGIAHTYMAAENLQKAADRLGVSIKVETQGGIGV ENKLTEEEIREADAIIIAADRSVNKDRFIGKKLLSVGVQDGIRKPEELIQKALNGDIP VYRSATKSESGNHQEKKQNPIYRHLMNGVSFMVPFIVVGGLLIAVALTLGGEKTPKGL VIPDDSFWKTIEQIGSASFSFMIPILAGYIAYSIADKPGLVPGMIGGYIAATGSFYDS ASGAGFLGGIIAGFLAGYAALWIKKLKVPKAIQPIMPIIIIPVFASLIVGLAFVFLIG APVAQIFASLTVWLAGMKGSSSILLALILGAMISFDMGGPVNKVAFLFGSAMIGEGNY EIMGPIAVAICIPPIGLGIATFLGKRKFEASQREMGKAAFTMGLFGITEGAIPFAAQD PLRVIPSIMAGSMTGSVIAMIGNVGDRVAHGGPIVAVLGAVDHVLMFFIAVIAGSLVT ALFVNVLKKDITASPVLSETAPTSAPSEAAAANEIKQPIQSQKAEMSEFKKLTDIISP ELIEPNLSGETSDDIIDELIQKLSRRGALLSESGFKQAILNREQQGTTAIGMNIAIPH GKSEAVREPSVAFGIKRSGVDWNSLDGSEAKLIFMIAVPKESGGNQHLKILQMLSRKL MDDNYRERLLSVQTTEEAYKLLEEIE*" gene 1254693..1256645 /gene="manP" /locus_tag="BSU_12010" /old_locus_tag="BSU12010" CDS 1256660..1257607 /gene="manA" /locus_tag="BSU_12020" /old_locus_tag="BSU12020" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 7934877, 20862359, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 7934877, 20862359, 23551403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannose-6 phosphate isomerase; cupin family" /protein_id="NP_389084.1" /db_xref="EnsemblGenomes-Gn:BSU12020" /db_xref="EnsemblGenomes-Tr:CAB13059" /db_xref="GOA:O31646" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13177" /db_xref="UniProtKB/Swiss-Prot:O31646" /translation="MTTEPLFFKPVFKERIWGGTALADFGYTIPSQRTGECWAFAAHQ NGQSVVQNGMYKGFTLSELWEHHRHLFGQLEGDRFPLLTKILDADQDLSVQVHPNDEY ANIHENGELGKTECWYIIDCQKDAEIIYGHNATTKEELTTMIERGEWDELLRRVKVKP GDFFYVPSGTVHAIGKGILALETQQNSDTTYRLYDYDRKDAEGKLRELHLKKSIEVIE VPSIPERHTVHHEQIEDLLTTTLIECAYFSVGKWNLSGSASLKQQKPFLLISVIEGEG RMISGEYVYPFKKGDHMLLPYGLGEFKLEGYAECIVSHL*" gene 1256660..1257607 /gene="manA" /locus_tag="BSU_12020" /old_locus_tag="BSU12020" S_feature 1257608..1257706 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1257681..1257687 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1257702..1257721 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1257708..1257776 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1257708 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" CDS 1257777..1258259 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" gene 1257777..1258259 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" downshifts 1258239 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" CDS complement(1258305..1258811) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" gene complement(1258305..1258811) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" downshifts complement(1258329) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" misc_feature complement(1258836..1258855) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1258842) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" S_feature complement(1258844..1259029) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1259030..1259425) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" gene complement(1259030..1259425) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" promotor_-10 complement(1259448..1259466) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1259461) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" S_feature complement(1259463..1260163) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1259481..1259486) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1259569..1259576 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1259590..1259609 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1259601 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" CDS 1259654..1260133 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " gene 1259654..1260133 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" downshifts 1260132 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" CDS complement(1260173..1260367) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" gene complement(1260173..1260367) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" downshifts complement(1260208) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" promotor_-10 complement(1260381..1260396) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1260397) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" promotor_-35 complement(1260408..1260417) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1260533..1260862) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" gene complement(1260533..1260862) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" promotor_-10 complement(1260899..1260918) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1260912) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" S_feature complement(1260914..1261481) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1260933..1260938) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1260966..1260970 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1260986..1261005 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1260990..1261491 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1260990 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" CDS complement(1261482..1262471) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" gene complement(1261482..1262471) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" promotor_-10 complement(1262472..1262491) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1262475) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" promotor_-35 complement(1262505..1262510) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1262594..1262842) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" gene complement(1262594..1262842) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" downshifts complement(1262604) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" promotor_-35 1262838..1262842 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1262851..1262865 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1262860 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1262867..1262886) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1262876) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" promotor_-35 complement(1262900..1262909) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1262957..1262964 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1262971..1262990) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1262978..1262997 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1262980) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" upshifts 1262991 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" S_feature 1262992..1263095 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1263004..1263011) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1263096..1264499 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" gene 1263096..1264499 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" downshifts 1264488 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" CDS complement(1264539..1265012) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" gene complement(1264539..1265012) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" downshifts complement(1264543) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(1265034..1265052) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1265052) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" promotor_-35 complement(1265067..1265072) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1265137..1265304) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" gene complement(1265137..1265304) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" downshifts complement(1265140) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" promotor_-10 complement(1265316..1265334) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1265325) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" promotor_-35 complement(1265347..1265354) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1265431..1266330 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" gene 1265431..1266330 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" CDS complement(1266339..1266737) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" gene complement(1266339..1266737) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" downshifts complement(1266369) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" promotor_-10 complement(1266766..1266785) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1266785) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" promotor_-35 complement(1266800..1266807) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1266838..1267413) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" gene complement(1266838..1267413) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" downshifts complement(1266853) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" promotor_-10 complement(1267432..1267450) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1267447) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" promotor_-35 complement(1267464..1267470) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1267488..1267494 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1267509..1267527 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1267510 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" CDS 1267559..1270516 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" gene 1267559..1270516 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" CDS 1270509..1271069 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" gene 1270509..1271069 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" downshifts 1271062 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" S_feature 1271107..1271225 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1271203..1271206 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1271222..1271241 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1271227 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" CDS 1271266..1271907 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" gene 1271266..1271907 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" downshifts complement(1271275) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" downshifts 1271880 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" CDS 1271986..1272612 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" gene 1271986..1272612 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" downshifts 1272614 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" downshifts complement(1272617) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" CDS complement(1272643..1272921) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" gene complement(1272643..1272921) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" downshifts complement(1272661) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1272950..1272961) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1272963..1272969) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1272969) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" S_feature complement(1272971..1273387) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1273139 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" misc_feature 1273140..1273159 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1273157..1273311 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1273312..1274502 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" gene 1273312..1274502 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" promotor_-10 complement(1273385..1273404) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1273387) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" promotor_-35 complement(1273418..1273427) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1274525..1275703 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" gene 1274525..1275703 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" CDS complement(1275744..1275932) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" gene complement(1275744..1275932) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" downshifts complement(1275760) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" promotor_-10 complement(1275958..1275977) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1275961) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" promotor_-35 complement(1275991..1275997) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1276019..1276026 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1276041..1276060 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1276052 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" promotor_-10 complement(1276067..1276086) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1276071) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1276101..1276108) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1276106..1276918 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" gene 1276106..1276918 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" downshifts 1276897 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" CDS complement(1276964..1277716) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" gene complement(1276964..1277716) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" downshifts complement(1276973) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" CDS complement(1277716..1278468) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" gene complement(1277716..1278468) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" CDS complement(1278588..1279562) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" gene complement(1278588..1279562) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" downshifts complement(1278623) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1279583..1279602) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1279609) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" S_feature complement(1279611..1282117) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1279617..1279624) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1279645..1279651 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1279666..1279684 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1279669 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" CDS 1279694..1280191 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" gene 1279694..1280191 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" S_feature 1280192..1280305 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1280285..1280289 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1280305..1280324 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1280307..1280579 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1280307 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" CDS 1280580..1281002 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" gene 1280580..1281002 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" CDS 1281042..1282220 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" gene 1281042..1282220 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" promotor_no_box 1282051..1282151 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1282109..1282127) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1282111 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1282117) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" promotor_-35 complement(1282139..1282147) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1282219 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" promotor_-35 1282328..1282335 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1282350..1282369 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1282375 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" CDS 1282418..1283839 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" gene 1282418..1283839 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" CDS 1283907..1285286 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" gene 1283907..1285286 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" promotor_-10 complement(1284426..1284445) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1284431) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1284459..1284466) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1285311 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" misc_feature 1285321..1285328 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1285323..1285390 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1285391..1286404 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" gene 1285391..1286404 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" CDS 1286410..1287429 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" gene 1286410..1287429 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" CDS 1287454..1288533 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" gene 1287454..1288533 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" CDS 1288530..1289366 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" gene 1288530..1289366 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" CDS 1289414..1290682 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" gene 1289414..1290682 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" promotor_-35 1290626..1290629 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1290645..1290649 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1290647 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" misc_feature 1290715..1290734 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1290715 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" CDS 1290770..1291771 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " gene 1290770..1291771 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" promotor_no_box complement(1291453..1291553) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1291493) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1291747 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" CDS 1291848..1293290 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" gene 1291848..1293290 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" CDS 1293287..1294780 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" gene 1293287..1294780 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" CDS complement(1294819..1295583) /gene="yjnA" /locus_tag="BSU_12400" /old_locus_tag="BSU12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGSIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" gene complement(1294819..1295583) /gene="yjnA" /locus_tag="BSU_12400" /old_locus_tag="BSU12400" downshifts complement(1294838) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" SCAR join(1295610,1295617) /created_by="User" /modified_by="User" /label="TF8A" N_region 1295611..1295616 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1295619..1295939 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1295619..1295939 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1295948 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" S_feature complement(1295957..1296160) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1295976..1296113) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" gene complement(1295976..1296113) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" downshifts complement(1296000) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" CDS complement(1296199..1296369) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" gene complement(1296199..1296369) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" downshifts complement(1296205) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" CDS complement(1296369..1297115) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" gene complement(1296369..1297115) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" promotor_-10 complement(1296950..1296969) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1296967) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" promotor_-35 complement(1296985..1296992) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1297141..1297159) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1297154) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" promotor_-35 complement(1297175..1297180) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1297225..1298226) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " gene complement(1297225..1298226) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" downshifts complement(1297254) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" CDS complement(1298239..1298856) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" gene complement(1298239..1298856) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" promotor_-10 complement(1298892..1298911) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1298894) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" S_feature complement(1298896..1298993) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1298927..1298931) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1298973..1298992) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1298993) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" promotor_-35 complement(1299007..1299014) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1299038..1299057) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1299050) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" CDS complement(1299132..1300448) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" gene complement(1299132..1300448) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" downshifts complement(1299147) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(1300495..1300514) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1300511) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" promotor_-35 complement(1300529..1300532) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1300731..1300738 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1300753..1300772 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1300765..1300836 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1300765 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" CDS 1300837..1301787 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" gene 1300837..1301787 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" downshifts 1301775 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" CDS 1301888..1302034 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" gene 1301888..1302034 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" CDS 1302042..1304192 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" gene 1302042..1304192 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" promotor_no_box 1302931..1303031 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1302991 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1303079 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" CDS 1304204..1305175 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" gene 1304204..1305175 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" S_feature complement(1304532..1305173) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1305218) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" S_feature complement(1305243..1305609) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1305286) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" promotor_-10 complement(1305589..1305604) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1305609) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" promotor_-35 complement(1305616..1305625) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1305693..1307042) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " gene complement(1305693..1307042) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" downshifts complement(1305707) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" promotor_-35 1307082..1307089 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1307094..1307113) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1307102 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" promotor_-10 1307104..1307123 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1307112) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" S_feature complement(1307114..1307196) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1307124..1307131) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1307153..1307159 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1307174..1307193 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1307177 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" promotor_-10 complement(1307179..1307198) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1307196) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" CDS 1307211..1308029 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" gene 1307211..1308029 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" promotor_-35 complement(1307214..1307217) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1308007 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" promotor_-35 1308086..1308093 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1308108..1308127 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1308112 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" CDS 1308158..1308982 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" gene 1308158..1308982 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" CDS 1308999..1309925 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" gene 1308999..1309925 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" CDS 1309931..1310893 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" gene 1309931..1310893 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" promotor_-35 1310625..1310630 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1310646..1310664 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1310647 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" CDS 1310898..1311905 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" gene 1310898..1311905 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" CDS 1311908..1313557 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" gene 1311908..1313557 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" downshifts 1313551 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" CDS 1313645..1314604 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" gene 1313645..1314604 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" CDS 1314601..1315701 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" gene 1314601..1315701 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" CDS 1315698..1316588 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" gene 1315698..1316588 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" CDS 1316601..1317590 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" gene 1316601..1317590 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" S_feature complement(1316884..1317611) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1317580 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" S_feature 1317625..1318793 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1317633..1318682) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" gene complement(1317633..1318682) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" downshifts complement(1317656) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1318709..1318728) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1318720) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" promotor_-35 complement(1318743..1318750) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1318772..1319632) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" gene complement(1318772..1319632) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" promotor_-10 complement(1319657..1319675) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1319674) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" promotor_-35 complement(1319691..1319697) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1319706..1319713 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1319727..1319746 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1319734 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" CDS 1319792..1320310 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" gene 1319792..1320310 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" downshifts 1320301 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" promotor_-35 1320375..1320381 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1320393..1320499 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1320393 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" promotor_-10 1320395..1320406 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1320474..1320477 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1320493..1320512 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1320501 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" CDS 1320549..1321748 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" gene 1320549..1321748 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" downshifts 1321737 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" S_feature 1321782..1322153 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1321825..1322049) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" gene complement(1321825..1322049) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" promotor_-35 1322129..1322135 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1322149..1322160 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1322155 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" CDS 1322194..1322925 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" gene 1322194..1322925 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" downshifts 1322903 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" promotor_-35 1322964..1322972 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1322983..1323001 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1322991 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" CDS 1323017..1323544 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" gene 1323017..1323544 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" CDS 1323534..1324052 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" gene 1323534..1324052 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" promotor_-35 1324046..1324053 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1324067..1324086 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1324070 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" misc_RNA 1324085..1324196 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" gene 1324085..1324196 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" downshifts 1324159 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" CDS 1324274..1324612 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" gene 1324274..1324612 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" CDS 1324612..1324929 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" gene 1324612..1324929 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" promotor_-35 1324929..1324932 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1324948..1324967 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1324960 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" CDS 1325000..1325902 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" gene 1325000..1325902 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" downshifts 1325893 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" promotor_-35 1325949..1325955 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1325961 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" promotor_-10 1325969..1325988 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1325990..1326200 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" gene 1325990..1326200 /gene="pswB" /locus_tag="BSU_misc_RNA_17" downshifts 1326158 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" CDS 1326253..1327350 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" gene 1326253..1327350 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" promotor_-35 1326440..1326442 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1326444..1326448 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1326444 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" CDS 1327362..1328609 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" gene 1327362..1328609 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" downshifts 1328600 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" promotor_-35 1328671..1328678 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1328693..1328712 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1328702 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" CDS 1328735..1329160 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" gene 1328735..1329160 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" downshifts 1329149 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" CDS complement(1329191..1329634) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" gene complement(1329191..1329634) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" downshifts complement(1329225) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" promotor_-10 complement(1329661..1329680) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1329667) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" promotor_-35 complement(1329695..1329698) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1329716..1329722 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1329736..1329754 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1329742 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" CDS 1329777..1330187 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" gene 1329777..1330187 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" downshifts 1330165 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" CDS 1330214..1330384 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" gene 1330214..1330384 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" S_feature 1330385..1331062 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1330434..1330904) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" gene complement(1330434..1330904) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" downshifts complement(1330458) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1330926..1330945) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1330942) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" S_feature complement(1330944..1331051) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1330961..1330964) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1331020 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" CDS complement(1331077..1333365) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" gene complement(1331077..1333365) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" downshifts complement(1331096) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" S_feature complement(1333366..1333428) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1333388..1333488) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1333428) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" misc_RNA complement(1333493..1333648) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" gene complement(1333493..1333648) /gene="mswB" /locus_tag="BSU_misc_RNA_18" downshifts complement(1333494) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" promotor_-10 complement(1333681..1333700) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1333693) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" S_feature complement(1333695..1333780) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1333716..1333723) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1333781..1334740) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" gene complement(1333781..1334740) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" S_feature complement(1334741..1334792) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1334785..1334804) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1334797) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" promotor_-35 complement(1334818..1334824) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1334909..1334912 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1334925 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" promotor_-10 1334928..1334947 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1334963..1335796 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" gene 1334963..1335796 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" downshifts 1335772 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" CDS complement(1335827..1336591) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" gene complement(1335827..1336591) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" downshifts complement(1335848) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" CDS complement(1336566..1338209) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" gene complement(1336566..1338209) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" CDS complement(1338196..1338795) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" gene complement(1338196..1338795) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" CDS complement(1338797..1339399) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" gene complement(1338797..1339399) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" downshifts complement(1339477) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" misc_RNA complement(1339496..1339608) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene complement(1339496..1339608) /gene="tswB" /locus_tag="BSU_misc_RNA_19" promotor_-35 1339609..1339612 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1339623..1339642) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1339628..1339647 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1339639 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1339644) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" promotor_-35 complement(1339657..1339664) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1339710..1340396 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" gene 1339710..1340396 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" CDS 1340400..1341764 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" gene 1340400..1341764 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" CDS 1341761..1342441 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" gene 1341761..1342441 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" promotor_-35 1342470..1342475 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1342491..1342509 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1342494 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" CDS 1342533..1343045 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" gene 1342533..1343045 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" downshifts 1343031 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" promotor_-35 1343076..1343082 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1343096..1343107 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1343097 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" CDS 1343128..1343265 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" gene 1343128..1343265 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" downshifts 1343238 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" promotor_-35 1343324..1343331 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1343345..1343364 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1343347..1343666 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1343347 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" misc_RNA 1343379..1343532 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" gene 1343379..1343532 /gene="swmG" /locus_tag="BSU_misc_RNA_68" promotor_-35 1343644..1343653 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1343666..1343685 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1343668..1343769 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1343668 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" CDS 1343770..1345125 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" gene 1343770..1345125 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" downshifts 1345116 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" CDS complement(1345168..1345500) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" gene complement(1345168..1345500) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" promotor_-10 complement(1345516..1345535) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1345526) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" S_feature complement(1345528..1345916) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1345551..1345556) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1345588..1345688 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1345648 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" CDS 1345695..1345850 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" gene 1345695..1345850 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" promotor_-35 1345859..1345866 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1345873..1345890 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1345890 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" promotor_-10 complement(1345901..1345920) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1345916) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" promotor_-35 complement(1345934..1345940) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1345938..1346120 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" gene 1345938..1346120 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" downshifts 1346088 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" promotor_-35 1346145..1346153 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1346164..1346182 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1346170..1346252 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1346170 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" CDS 1346253..1346717 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" gene 1346253..1346717 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" downshifts 1346702 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" CDS complement(1346732..1347853) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" gene complement(1346732..1347853) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" promotor_-35 1347141..1347149 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1347163..1347182 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1347166..1347944 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1347166 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" promotor_-10 complement(1347882..1347893) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1347902) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1347908..1347914) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1347945..1348496 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" gene 1347945..1348496 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" downshifts 1348464 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" CDS complement(1348524..1349336) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" gene complement(1348524..1349336) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" promotor_-10 complement(1349296..1349315) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1349310) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1349329..1349334) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1349437..1349443 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1349454..1349528 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1349454 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" promotor_-10 1349457..1349468 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1349529..1351223 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" gene 1349529..1351223 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" CDS 1351236..1352249 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" gene 1351236..1352249 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" downshifts 1352234 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" CDS complement(1352275..1354110) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" gene complement(1352275..1354110) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" downshifts complement(1352324) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" CDS complement(1354114..1355049) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" gene complement(1354114..1355049) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" promotor_-10 complement(1355020..1355031) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1355030) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" promotor_-35 complement(1355046..1355052) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1355086..1357488) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" gene complement(1355086..1357488) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" downshifts complement(1355118) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" S_feature complement(1357336..1357538) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1357527..1357545) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1357538) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" promotor_-35 complement(1357559..1357566) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1357605..1357612 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1357626..1357645 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1357638 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" CDS 1357669..1358334 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" gene 1357669..1358334 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" promotor_-10 complement(1358203..1358222) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1358220) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1358236..1358245) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1358329..1358336 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1358351..1358370 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1358364 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" misc_RNA 1358390..1358523 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" gene 1358390..1358523 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" CDS 1358411..1359385 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" gene 1358411..1359385 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" downshifts 1358474 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" downshifts 1359373 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" promotor_-35 1359495..1359503 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1359517..1359525 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1359527 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" S_feature 1359530..1359616 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1359589..1359596 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1359610..1359629 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1359618 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" CDS 1359649..1360404 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" gene 1359649..1360404 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" CDS 1360401..1361546 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" gene 1360401..1361546 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" S_feature 1361547..1362706 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1361557..1361751) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" gene complement(1361557..1361751) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" downshifts complement(1361564) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1361794..1361805) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1361804) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" promotor_-35 complement(1361820..1361826) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1361882..1362583) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" gene complement(1361882..1362583) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" downshifts complement(1361916) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" S_feature complement(1362584..1362664) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1362656..1362675) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1362664) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" promotor_-35 1362680..1362687 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1362689..1362696) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1362701..1362720 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1362708 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" CDS 1362754..1363650 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" gene 1362754..1363650 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" downshifts 1363644 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" promotor_-35 1363755..1363759 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1363775..1363794 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1363779 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" CDS 1363824..1365173 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " gene 1363824..1365173 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" downshifts 1365161 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" promotor_-35 1365222..1365228 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1365242..1365253 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1365250..1365317 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1365250 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" CDS 1365318..1365473 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" gene 1365318..1365473 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" CDS 1365476..1365652 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" gene 1365476..1365652 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" promotor_no_box 1365542..1365642 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1365602 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1365648 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" CDS complement(1365695..1366717) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" gene complement(1365695..1366717) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" downshifts complement(1365718) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" promotor_-10 complement(1366762..1366781) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1366778) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" promotor_-35 complement(1366793..1366799) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1366906..1366914 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1366922 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" promotor_-10 1366925..1366943 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1366970..1369186 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" gene 1366970..1369186 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" S_feature complement(1368961..1369901) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1369039..1369046 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1369061..1369080 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1369063 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" CDS 1369183..1369680 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" gene 1369183..1369680 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" S_feature 1369681..1369920 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1369770..1369895 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" gene 1369770..1369895 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" downshifts 1369888 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" CDS complement(1369929..1370990) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" gene complement(1369929..1370990) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" downshifts complement(1369946) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" CDS complement(1370998..1372191) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" gene complement(1370998..1372191) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" downshifts 1371058 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" downshifts complement(1372278) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" misc_RNA complement(1372284..1372440) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" gene complement(1372284..1372440) /gene="mswC" /locus_tag="BSU_misc_RNA_20" promotor_-10 complement(1372475..1372494) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1372476) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" promotor_-35 complement(1372510..1372517) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1372520..1372523 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1372524..1373303) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" gene complement(1372524..1373303) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" promotor_-10 1372539..1372558 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1372548 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1372996..1373003 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1373016..1373035 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1373031 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" S_feature 1373038..1373355 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1373325..1373332 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1373333..1373352) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1373347..1373366 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1373347) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" upshifts 1373357 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" promotor_-35 complement(1373368..1373375) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1373398..1374594 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" gene 1373398..1374594 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" promotor_-35 1374576..1374583 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1374598..1374617 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1374617 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" misc_RNA 1374633..1374733 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" gene 1374633..1374733 /gene="mswD" /locus_tag="BSU_misc_RNA_21" downshifts 1374732 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" CDS 1374818..1376035 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" gene 1374818..1376035 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" CDS 1376032..1376739 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" gene 1376032..1376739 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" CDS 1376697..1377326 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" gene 1376697..1377326 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" CDS 1377341..1377877 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" gene 1377341..1377877 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" S_feature complement(1377724..1377917) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1377877 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" CDS complement(1377918..1378238) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" gene complement(1377918..1378238) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" downshifts complement(1377976) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" S_feature complement(1378239..1378328) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1378264..1378270 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1378285..1378303 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1378295 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" S_feature 1378296..1378380 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1378310..1378329) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1378327) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" promotor_-35 complement(1378344..1378347) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1378354..1378361 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1378376..1378395 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1378382..1378440 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1378382 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" downshifts complement(1378438) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" CDS 1378441..1378698 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" gene 1378441..1378698 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" downshifts 1378692 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" CDS 1378784..1379215 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" gene 1378784..1379215 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" CDS complement(1379243..1380763) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /EC_number="2.7.13.3" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine kinase phosphorylating Spo0A" /protein_id="NP_389249.1" /db_xref="EnsemblGenomes-Gn:BSU13660" /db_xref="EnsemblGenomes-Tr:CAB13239" /db_xref="GOA:O31671" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4JGO" /db_xref="PDB:4JGP" /db_xref="PDB:4JGQ" /db_xref="PDB:4JGR" /db_xref="SubtiList:BG13309" /db_xref="UniProtKB/Swiss-Prot:O31671" /translation="MLERCKLKILKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIA AEHKQEASVLLNLHRNKINYLIGETMARMTSLSIAIDRPVDIKKMQSILEKTFDSEPR FSGLYFLNAKGDVTASTTELKTKVNLADRSFFIKAKETKKTVISDSYSSRITGQPIFT ICVPVLDSKRNVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAE DQKPVSGYLDDISWNMKVYPNPVTIEELSKSLVLPLSCIIVLLNILFILVLYYLLKRQ TQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIE QEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTE QPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQE MLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS*" gene complement(1379243..1380763) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" downshifts complement(1379255) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" promotor_-35 1379964..1379970 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1379984..1379995 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1379990 /Source="Nicolas_upshifts" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1380771..1380790) /Source="Nicolas_upshift_promotors" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1380792) /Source="Nicolas_upshifts" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" promotor_-35 1380890..1380897 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1380912..1380931 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1380914 /Source="Nicolas_upshifts" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" CDS 1380956..1381393 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17725564, 17962296, 18282125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17725564, 17962296, 18282125; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family)" /protein_id="NP_389250.1" /db_xref="EnsemblGenomes-Gn:BSU13670" /db_xref="EnsemblGenomes-Tr:CAB13240" /db_xref="GOA:O31672" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13310" /db_xref="UniProtKB/Swiss-Prot:O31672" /translation="MTEKSLKLFIVLSRAYRSINDHMNKHIHKHGLNPTEFAVLELLY HKGDQPLQQIGDKILLASGSITYVVDKLEQKELLIRKASPTDRRVTFAQITEKGIGLL NDIFPDHAAEIDEMISVLSEEEVEMCTEMLKRVGLNAKQFHNK*" gene 1380956..1381393 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" downshifts 1381376 /Source="Nicolas_upshifts" /id="D754" /incds=0 /nref=210 /ntot=257 /MaxReadThrough="1.20686" /MaxDrop="5.47215" /score="1.59181784" /energy="-8.9" /TU="U1110" /idTUdmin="U1110" /TUdmin="-22" /isTUend="TRUE" CDS complement(1381433..1382218) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein B; MotB component of the H+-coupled stator flagellum complex" /protein_id="NP_389251.1" /db_xref="EnsemblGenomes-Gn:BSU13680" /db_xref="EnsemblGenomes-Tr:CAB13241" /db_xref="GOA:P28612" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10689" /db_xref="UniProtKB/Swiss-Prot:P28612" /translation="MARKKKKKHEDEHVDESWLVPYADILTLLLALFIVLYASSSIDA AKFQMLSKSFNEVFTGGTGVLDYSSVTPPENESDGIDEVKKEKEEKEKNKKEKEKAAD QEELENVKSQVEKFIKDKKLEHQLETKMTSEGLLITIKDSIFFDSGKATIRKEDVPLA KEISNLLVINPPRNIIISGHTDNMPIKNSEFQSNWHLSVMRAVNFMGLLIENPKLDAK VFSAKGYGEYKPVASNKTAEGRSKNRRVEVLILPRGAAETNEK*" gene complement(1381433..1382218) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" downshifts complement(1381452) /Source="Nicolas_upshifts" /id="D755" /incds=0 /nref=224 /ntot=246 /MaxReadThrough="3.05351" /MaxDrop="6.69306" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-88" /isTUend="FALSE" downshifts complement(1381914) /Source="Nicolas_upshifts" /id="D756" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="8.03566" /MaxDrop="4.69358" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-550" /isTUend="FALSE" CDS complement(1382190..1383002) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein A; MotA component of the H+-coupled stator flagellum complex" /protein_id="NP_389252.1" /db_xref="EnsemblGenomes-Gn:BSU13690" /db_xref="EnsemblGenomes-Tr:CAB13242" /db_xref="GOA:P28611" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10688" /db_xref="UniProtKB/Swiss-Prot:P28611" /translation="MDKTSLIGIILAFVALSVGMVLKGVSFSALANPAAILIIIAGTI SAVVIAFPTKEIKKVPTLFRVLFKENKQLTIEELIPMFSEWAQLARREGLLALEASIE DVDDAFLKNGLSMAVDGQSAEFIRDIMTEEVEAMEDRHQAGAAIFTQAGTYAPTLGVL GAVIGLIAALSHMDNTDELGHAISAAFVATLLGIFTGYVLWHPFANKLKRKSKQEVKL REVMIEGVLSVLEGQAPKVIEQKLLMYLPAKDRLKFAEQGEAQNGEKKEEEA*" gene complement(1382190..1383002) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" promotor_-10 complement(1383033..1383051) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1383049) /Source="Nicolas_upshifts" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" promotor_-35 complement(1383065..1383072) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1383140..1383362) /Source="Nicolas_S_feature" /locus_tag="new_1435383_1435605_c" /HighExp="Diami, dia15, dia5, Heat, Etha, LPhT, H2O2, C30, G135, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.93062599999999995" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S491" downshifts complement(1383172) /Source="Nicolas_upshifts" /id="D757" /incds=0 /nref=5 /ntot=12 /MaxReadThrough="0.48394" /MaxDrop="4.60081" /score="30.9355071" /energy="-15.4" /TU="NA" /idTUdmin="U1112" /TUdmin="-4" /isTUend="TRUE" CDS complement(1383385..1385484) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" gene complement(1383385..1385484) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" downshifts complement(1383407) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" S_feature complement(1385485..1385735) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1385695..1385795) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1385735) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" promotor_-35 1385771..1385776 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1385786 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" promotor_-10 1385792..1385810 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1385849..1386892 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" gene 1385849..1386892 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" S_feature 1386893..1386984 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1386961..1386965 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1386982..1387001 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1386986 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" misc_RNA 1387031..1387075 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" gene 1387031..1387075 /gene="qswA" /locus_tag="BSU_misc_RNA_22" downshifts 1387052 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" S_feature 1387097..1387204 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1387205..1387864 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" gene 1387205..1387864 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" CDS 1387857..1388306 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" gene 1387857..1388306 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" CDS 1388299..1389030 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" gene 1388299..1389030 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" CDS 1389048..1389545 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" gene 1389048..1389545 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" S_feature 1389546..1389822 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1389780 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" downshifts complement(1389790) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" S_feature complement(1389859..1390103) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1389900) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" CDS complement(1390104..1390460) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" gene complement(1390104..1390460) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" misc_feature complement(1390491..1390510) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1390508) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" promotor_-35 1390526 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1390545..1390563 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1390550 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" CDS 1390629..1391375 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" gene 1390629..1391375 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" downshifts 1391430 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" promotor_-35 1391778..1391786 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1391800..1391819 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1391804 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" CDS 1391856..1393055 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" gene 1391856..1393055 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" promotor_-35 1391938..1391944 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1391959..1391977 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1391965 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" promotor_-35 1393024..1393026 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1393046..1393064 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1393058 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" CDS 1393071..1393298 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" gene 1393071..1393298 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" misc_feature complement(1393148..1393167) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1393156) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 1393299..1393394 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1393395..1394093 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" gene 1393395..1394093 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo S_feature complement(1394046..1394872) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1394074..1394325 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" gene 1394074..1394325 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo misc_feature 1394575..1394590 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1394598..1394809 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1394598 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" downshifts 1394774 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1394861..1394880) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1394883) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" promotor_-35 complement(1394896..1394903) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1394948..1394955 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1394970..1394989 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1394972 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" CDS 1395008..1395298 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" gene 1395008..1395298 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" S_feature complement(1395335..1395418) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1395378) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" CDS complement(1395419..1395604) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" gene complement(1395419..1395604) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" promotor_-10 complement(1395637..1395656) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1395648) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" S_feature complement(1395650..1395994) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1395670..1395677) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1395703..1395708 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1395724..1395743 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1395731 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" CDS 1395770..1395964 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" gene 1395770..1395964 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" downshifts 1395940 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" promotor_-10 complement(1395985..1396003) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1396001) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" promotor_-35 complement(1396020..1396025) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1396263..1396889 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" gene 1396263..1396889 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" downshifts 1396820 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" promotor_-35 1396946..1396951 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1396958 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" promotor_-10 1396967..1396985 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1397007..1398344 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" gene 1397007..1398344 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" CDS 1398395..1398892 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" gene 1398395..1398892 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" promotor_-35 1398741..1398747 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1398756 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1398762..1398780 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1398866 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" promotor_-35 1398987..1398993 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1399004..1399023 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1399016 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" S_feature 1399020..1399127 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1399128..1401041 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" gene 1399128..1401041 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" promotor_-10 complement(1399277..1399296) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1399294) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1399309..1399318) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1399445..1399464) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1399470) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1399478..1399484) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1401022 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" downshifts complement(1401098) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1401309..1401328) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1401318) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1401342..1401349) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1401393..1401412 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1401403 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" CDS 1401448..1402539 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" gene 1401448..1402539 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" downshifts 1402188 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" downshifts 1402518 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" S_feature complement(1402552..1402770) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1402563..1402820 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1402757..1402776) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1402770) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" promotor_-35 complement(1402792..1402799) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1402821..1403786 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" gene 1402821..1403786 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" promotor_-35 1403804..1403811 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1403826..1403845 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1403838 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" CDS 1403849..1404715 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" gene 1403849..1404715 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" promotor_-35 1404570..1404574 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1404591..1404610 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1404599 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" downshifts 1404717 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" misc_RNA 1404762..1404913 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" S_feature 1404762..1404913 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1404762..1404913 /gene="gswA" /locus_tag="BSU_misc_RNA_88" promotor_-35 1404891..1404897 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1404911..1404922 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1404915 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" CDS 1404944..1407043 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" gene 1404944..1407043 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" promotor_-35 1407061..1407065 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1407081..1407100 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1407092 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" CDS 1407141..1407407 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" gene 1407141..1407407 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" CDS 1407407..1409119 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" gene 1407407..1409119 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" downshifts 1409106 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" promotor_-35 1409159..1409165 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1409180..1409191 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1409183 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" CDS 1409210..1409449 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" gene 1409210..1409449 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" S_feature complement(1409230..1410569) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1409527..1410555 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" gene 1409527..1410555 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" downshifts 1410525 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" CDS complement(1410570..1411250) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" gene complement(1410570..1411250) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" promotor_-10 complement(1411260..1411279) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1411283) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" promotor_-35 complement(1411294..1411301) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1411335..1411342 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1411356..1411374 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1411362 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" CDS 1411385..1413352 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" gene 1411385..1413352 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" misc_feature complement(1411825..1411840) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1411837) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1413323 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" promotor_-35 1413396..1413398 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1413414..1413433 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1413424 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" downshifts complement(1413466) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" CDS 1413490..1414356 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" gene 1413490..1414356 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" downshifts 1414336 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" CDS complement(1414395..1415168) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" gene complement(1414395..1415168) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" downshifts complement(1414412) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" misc_feature complement(1415200..1415219) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1415210) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" misc_feature 1415443..1415462 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1415456 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" S_feature 1415458..1415561 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1415505..1417619 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" gene 1415505..1417619 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" promotor_-10 complement(1416798..1416816) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1416810) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1416832..1416837) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1417600 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" promotor_-35 1417692..1417700 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1417712..1417730 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1417724 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" CDS 1417783..1419603 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" gene 1417783..1419603 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" CDS complement(1419614..1420795) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" gene complement(1419614..1420795) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" downshifts complement(1419648) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" misc_feature complement(1420823..1420842) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1420839) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" promotor_-10 complement(1420871..1420889) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1420883) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" S_feature complement(1420885..1420953) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1420904..1420909) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1420947..1420966) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1420953) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" CDS complement(1420997..1421158) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" gene complement(1420997..1421158) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" promotor_-10 complement(1421181..1421200) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1421194) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" promotor_-35 complement(1421214..1421221) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1421295..1421302 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1421314 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" promotor_-10 1421315..1421333 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1421362..1422273 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" gene 1421362..1422273 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" downshifts complement(1421367) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" promotor_-35 1421816..1421824 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1421838..1421855 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1421841 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1422258 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" CDS complement(1422317..1422781) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" gene complement(1422317..1422781) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" downshifts complement(1422335) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1422811..1422830) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1422821) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" promotor_-35 complement(1422845..1422852) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1422907..1424199) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" gene complement(1422907..1424199) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" downshifts complement(1422929) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1424223..1424242) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1424227) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" promotor_-35 complement(1424258..1424262) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1424275..1424769) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" gene complement(1424275..1424769) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" promotor_-10 complement(1424785..1424804) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1424801) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" promotor_-35 complement(1424818..1424827) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1424826..1425686) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" gene complement(1424826..1425686) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" misc_feature complement(1425707..1425726) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1425720) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" promotor_-35 1425757..1425764 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1425780..1425799 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1425793 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" CDS 1425829..1426593 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" gene 1425829..1426593 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" S_feature 1426594..1426742 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1426723..1426741 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1426744..1426893 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1426744 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" downshifts complement(1426791) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" CDS 1426894..1428624 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" gene 1426894..1428624 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" CDS 1428690..1429208 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" gene 1428690..1429208 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" downshifts 1429206 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" promotor_-35 1429251..1429256 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1429269..1429288 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1429272 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" CDS 1429304..1429852 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" gene 1429304..1429852 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" S_feature 1429853..1430004 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1430005..1431228 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" gene 1430005..1431228 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" promotor_-10 complement(1431191..1431209) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1431201) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1431207 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" promotor_-35 complement(1431224..1431229) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1431277..1431284 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1431296..1431397 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1431296 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" promotor_-10 1431299..1431318 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1431314..1431397 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" gene 1431314..1431397 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" downshifts 1431354 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" promotor_-35 1431408..1431413 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1431428..1431712 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1431428 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" promotor_-10 1431430..1431448 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1431689..1431695 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1431709..1431720 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1431714..1431801 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1431714 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" misc_feature 1431790..1431809 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1431803 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" CDS 1431874..1432113 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" gene 1431874..1432113 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" S_feature 1432114..1432222 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1432223..1432741 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" gene 1432223..1432741 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" promotor_-35 1432778..1432785 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1432799..1432818 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1432813 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" CDS 1432875..1433072 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" gene 1432875..1433072 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" downshifts 1433068 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" S_feature 1433113..1433209 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1433210..1433653 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" gene 1433210..1433653 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" S_feature 1433654..1433761 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1433729..1433734 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1433749..1433768 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1433763 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" CDS 1433802..1434683 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" gene 1433802..1434683 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" downshifts 1434662 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" promotor_-35 1434718..1434725 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1434740..1434759 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1434745 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" CDS 1434795..1435271 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" gene 1434795..1435271 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" CDS 1435261..1436154 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" gene 1435261..1436154 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" CDS 1436170..1436625 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" gene 1436170..1436625 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" promotor_-10 complement(1436441..1436460) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1436454) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1436474..1436482) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1436619 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" promotor_-35 1436664..1436671 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1436685..1436704 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1436686 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" CDS 1436730..1437440 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" gene 1436730..1437440 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" downshifts complement(1436739) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1436849..1436853) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1436849) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1436871) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1437510..1438634 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" gene 1437510..1438634 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" promotor_-35 1438646..1438652 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1438666..1438677 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1438668 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" promotor_-10 complement(1438672..1438686) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1438696..1438700) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1438696..1438941 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" gene 1438696..1438941 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" upshifts complement(1438697) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1438929 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" S_feature 1438974..1439924 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1438978..1439781) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" gene complement(1438978..1439781) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" downshifts complement(1438990) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" promotor_-10 complement(1439832..1439851) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1439841) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" promotor_-35 complement(1439865..1439872) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1439897..1439904 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1439919..1439938 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1439926..1440017 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1439926 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" CDS 1440018..1440560 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" gene 1440018..1440560 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" CDS 1440632..1441078 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" gene 1440632..1441078 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" downshifts 1441086 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" promotor_-35 1441471..1441478 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1441491 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" promotor_-10 1441493..1441512 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1441544..1442119 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" gene 1441544..1442119 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" downshifts 1442097 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" CDS complement(1442160..1443125) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" gene complement(1442160..1443125) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" downshifts complement(1442173) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" promotor_-35 1442469..1442470 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1442488..1442507 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1442494..1443218 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1442494 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" promotor_-10 complement(1443146..1443164) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1443167) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" promotor_-35 complement(1443179..1443184) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1443205..1443211 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1443221 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" promotor_-10 1443225..1443244 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1443262..1443861 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" gene 1443262..1443861 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" CDS 1443912..1444931 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" gene 1443912..1444931 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" CDS 1444949..1446241 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" gene 1444949..1446241 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" CDS 1446202..1446723 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" gene 1446202..1446723 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" CDS 1446723..1447196 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" gene 1446723..1447196 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" CDS 1447189..1447422 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" gene 1447189..1447422 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" downshifts 1447401 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" promotor_-35 1447467..1447472 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1447489..1447507 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1447497 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" S_feature 1447509..1447595 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1447585..1447588 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1447597 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1447603..1447622 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1447646..1449403 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" gene 1447646..1449403 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" CDS 1449415..1451229 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" gene 1449415..1451229 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" promotor_-10 complement(1449852..1449871) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1449862) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1449886..1449893) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1451280..1451289 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1451301..1451316 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1451305 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" CDS 1451339..1452034 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" gene 1451339..1452034 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" CDS 1452039..1453172 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" gene 1452039..1453172 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" CDS 1453173..1453865 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" gene 1453173..1453865 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" CDS 1453862..1455055 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" gene 1453862..1455055 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" downshifts 1455033 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" promotor_-35 1455104..1455110 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1455124..1455135 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1455132 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" promotor_-35 1455177..1455184 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1455199..1455218 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1455204..1455295 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1455204 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" promotor_-35 1455259..1455266 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1455280..1455299 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1455297 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" CDS 1455335..1456090 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" gene 1455335..1456090 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" upshifts complement(1455483) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1455485..1455487) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1455505) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1456087..1456998 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" gene 1456087..1456998 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" CDS 1457013..1458920 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" gene 1457013..1458920 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" downshifts 1458905 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" promotor_-35 1458989..1458996 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1459007..1459026 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1459010 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" CDS 1459065..1459646 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" gene 1459065..1459646 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" downshifts 1459631 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" downshifts 1459675 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" CDS complement(1459680..1459949) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" gene complement(1459680..1459949) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" downshifts complement(1459685) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" S_feature complement(1459950..1460015) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1459996..1460015) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1460015) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" promotor_-35 1460068..1460075 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1460086..1460105 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1460090 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" CDS 1460130..1461752 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" gene 1460130..1461752 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" downshifts 1461740 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" CDS 1461809..1462720 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" gene 1461809..1462720 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" downshifts 1462725 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" CDS complement(1462754..1463986) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" gene complement(1462754..1463986) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" downshifts complement(1462765) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1464004..1464023) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1464028) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" promotor_-35 complement(1464038..1464043) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1464096..1464230) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" gene complement(1464096..1464230) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" downshifts complement(1464107) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1464252..1464270) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1464263) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" S_feature complement(1464265..1464330) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1464286..1464291) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1464331..1465338) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" gene complement(1464331..1465338) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" upshifts complement(1465384) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" promotor_-10 complement(1465385..1465393) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1465407..1465415) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1465525..1465534 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1465546 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" promotor_-10 1465547..1465562 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1465549..1465621 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1465622..1465900 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" gene 1465622..1465900 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" downshifts 1465898 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" S_feature complement(1465932..1467561) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1465943..1466047 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1465955) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" promotor_-35 1466029..1466036 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1466048..1466067 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1466049 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" CDS 1466090..1467376 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" gene 1466090..1467376 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" CDS 1467392..1468225 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" gene 1467392..1468225 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" promotor_-10 complement(1467558..1467576) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1467573) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" promotor_-35 complement(1467592..1467597) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1468288..1468953 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" gene 1468288..1468953 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" downshifts 1468937 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" promotor_-35 1469044..1469050 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1469065..1469084) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1469065..1469084 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1469077 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" upshifts complement(1469079) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1469108..1470841 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" gene 1469108..1470841 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" S_feature complement(1470236..1470840) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1470830 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" CDS complement(1470875..1472542) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" gene complement(1470875..1472542) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" downshifts complement(1470885) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" CDS complement(1472548..1472757) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" gene complement(1472548..1472757) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" promotor_-10 complement(1472794..1472813) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1472816) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" S_feature complement(1472818..1472995) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1472828..1472831) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1472996) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" promotor_-10 complement(1472998..1473009) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1473023..1473029) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1473068..1473075 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1473089..1473108 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1473105 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" CDS 1473143..1473916 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" gene 1473143..1473916 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" downshifts 1473887 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" CDS complement(1473952..1474506) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" gene complement(1473952..1474506) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" downshifts complement(1473963) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1474528..1474547) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1474538) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" promotor_-35 complement(1474562..1474569) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1474591 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" downshifts complement(1474615) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" CDS complement(1474616..1474774) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" gene complement(1474616..1474774) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" CDS complement(1474681..1474824) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" gene complement(1474681..1474824) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" promotor_-35 1474770..1474774 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1474775..1474843) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1474784..1474798 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1474811 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1474827..1474846) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1474856) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" promotor_-35 complement(1474859..1474868) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1474930..1474937 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1474951..1474970 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1474955 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" CDS 1474988..1475659 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" gene 1474988..1475659 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" promotor_-35 1475327..1475336 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1475349..1475367 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1475361 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1475606 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" promotor_-35 1475834..1475839 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1475856..1475875 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1475857..1476082 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1475857 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" misc_feature complement(1475861..1475880) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1475877) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1475981..1475989) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1475987) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1476003..1476011) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1476083..1477198 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" gene 1476083..1477198 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" CDS 1477202..1478179 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" gene 1477202..1478179 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" S_feature 1478180..1478293 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1478214..1478233) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1478231) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1478248..1478251) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1478294..1479622 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" gene 1478294..1479622 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" promotor_-35 1478438..1478445 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1478460..1478479 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1478463 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" CDS 1479627..1481039 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" gene 1479627..1481039 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" downshifts 1481036 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" CDS complement(1481084..1481458) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" gene complement(1481084..1481458) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" downshifts complement(1481132) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" misc_feature complement(1481489..1481508) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1481499) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" promotor_-35 1481662..1481667 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1481683..1481701 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1481693 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" S_feature 1481697..1481806 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1481729) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" promotor_-35 1481790..1481797 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1481808 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" promotor_-10 1481812..1481831 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1481827..1482037 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" gene 1481827..1482037 /gene="srrA" /locus_tag="BSU_misc_RNA_70" CDS 1481877..1481996 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" gene 1481877..1481996 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" downshifts complement(1481883) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" downshifts 1481983 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" S_feature 1482028..1483631 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1482036..1483508) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" gene complement(1482036..1483508) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" downshifts complement(1482054) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" S_feature complement(1483509..1483604) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1483587..1483606) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1483604) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" promotor_-35 1483611..1483614 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1483621..1483628) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1483629..1483648 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1483633 /Source="Nicolas_upshifts" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" CDS 1483693..1483959 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389347.1" /db_xref="EnsemblGenomes-Gn:BSU14640" /db_xref="EnsemblGenomes-Tr:CAB13337" /db_xref="InterPro:IPR007920" /db_xref="InterPro:IPR023324" /db_xref="SubtiList:BG11816" /db_xref="UniProtKB/Swiss-Prot:Q45497" /translation="MEYQYPMNEDWTTEEAVDVIAFFQQVELAYEKGADREELLKAYR RFKEIVPGKAEEKKLCGEFEEQSTYSPYRTVKQARESDHAKIKM*" gene 1483693..1483959 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" downshifts 1483941 /Source="Nicolas_upshifts" /id="D825" /incds=0 /nref=105 /ntot=250 /MaxReadThrough="2.62284" /MaxDrop="5.09814" /score="40.0811023" /energy="-16.1" /TU="NA" /idTUdmin="U1214" /TUdmin=0 /isTUend="TRUE" CDS complement(1483992..1484630) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25643072" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389348.1" /db_xref="EnsemblGenomes-Gn:BSU14650" /db_xref="EnsemblGenomes-Tr:CAB13338" /db_xref="InterPro:IPR009403" /db_xref="PDB:2A8E" /db_xref="SubtiList:BG11817" /db_xref="UniProtKB/Swiss-Prot:Q45498" /translation="MTQMRFTEEDFNTFTIEGLDARMEVLKETVRPKLTALGEHFAPT LSALTGDEMFPHVAKHARRSVNPPADSWVAFANSKRGYKKLPHFQIGLWESHVFVWFA IIYESPIKEEYGKLLEVNQETITKNIPDSFVWSADHTKPGVHKQSEMDKEQLKTLFER LQTVKKAELLCGIQLQKEEVLNMNNQEFLQRIDDAFKQLAFLYRLTQKVTQA*" gene complement(1483992..1484630) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" downshifts complement(1484017) /Source="Nicolas_upshifts" /id="D826" /incds=0 /nref=184 /ntot=257 /MaxReadThrough="2.62959" /MaxDrop="6.54203" /score="26.7765804" /energy="-14.5" /TU="U1217" /idTUdmin="U1217" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(1484651..1484670) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1484675) /Source="Nicolas_upshifts" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" promotor_-35 complement(1484685..1484689) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1484700..1484706 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1484721..1484739 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1484722 /Source="Nicolas_upshifts" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" promotor_-35 1484760..1484769 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1484782..1484801 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1484786..1484869 /Source="Nicolas_S_feature" /locus_tag="new_1537029_1537112" /HighExp="Etha, S7, M9-stat, S6, S8, BT, Gly, Salt, B60, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S536" upshifts 1484786 /Source="Nicolas_upshifts" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" CDS 1484870..1485058 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved general stress protein" /protein_id="NP_389349.1" /db_xref="EnsemblGenomes-Gn:BSU14660" /db_xref="EnsemblGenomes-Tr:CAB13339" /db_xref="SubtiList:BG13337" /db_xref="UniProtKB/Swiss-Prot:O31719" /translation="MRQVVKEGFKEEKNNRVAVWRLEVDYELATLYEAMQKENEEQIE QSKNKLERLRKEWIRLNG*" gene 1484870..1485058 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" downshifts complement(1484875) /Source="Nicolas_upshifts" /id="D827" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="1.50398" /MaxDrop="3.97385" /score="26.7765804" /energy="-14.5" /TU="NA" /idTUdmin="U1220" /TUdmin=0 /isTUend="TRUE" downshifts 1485051 /Source="Nicolas_upshifts" /id="D828" /incds=0 /nref=13 /ntot=45 /MaxReadThrough="7.33866" /MaxDrop="6.12123" /score="-8.73613673" /energy="-8.1" /TU="U1218,U1219" /idTUdmin="U1219" /TUdmin="-628" /isTUend="FALSE" upshifts complement(1485073) /Source="Nicolas_upshifts" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1485081..1485084) /Source="Nicolas_upshift_promotors" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1485128..1485131 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1485148..1485167 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1485151 /Source="Nicolas_upshifts" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" CDS 1485198..1485995 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /EC_number="3.1.3.-" /EC_number="3.1.3.25" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914086, 16682444, 22333191, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914086, 16682444, 22333191, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inositol monophosphatase / 5' nucleotidase (purine nucleoside monophosphate)" /protein_id="NP_389350.1" /db_xref="EnsemblGenomes-Gn:BSU14670" /db_xref="EnsemblGenomes-Tr:CAB13340" /db_xref="GOA:Q45499" /db_xref="InterPro:IPR000760" /db_xref="InterPro:IPR020550" /db_xref="InterPro:IPR020583" /db_xref="InterPro:IPR033942" /db_xref="SubtiList:BG11818" /db_xref="UniProtKB/Swiss-Prot:Q45499" /translation="MTNWTEIDEIAKKWIREAGARITQSMHESLTIETKSNPNDLVTN IDKETEKFFIDRIQETFPGHRILGEEGQGDKIHSLEGVVWIIDPIDGTMNFVHQQRNF AISIGIFENGEGKIGLIYDVVHDELYHAFSGRGAYMNETKLAPLKETVIEEAILAINA TWVTENRRIDQSVLAPLVKRVRGTRSYGSAALELANVAAGRIDAYITMRLAPWDYAAG CVLLNEVGGTYTTIEGEPFTFLENHSVLAGNPSIHKTIFEEYLHARK*" gene 1485198..1485995 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" CDS 1486021..1486449 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389351.1" /db_xref="EnsemblGenomes-Gn:BSU14680" /db_xref="EnsemblGenomes-Tr:CAB13341" /db_xref="GOA:O31720" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13331" /db_xref="UniProtKB/Swiss-Prot:O31720" /translation="MLEKLAEAHPVWKEEEFGDKDAEDYIISYSMYNGSWLVWEKDGM PVAVSYHLEWSPSNGKPWLGTVLIDPAEEKKGHAKMIIEQISKLLRAKHKAMFAGVPI ERREWILFLSQCGFEQLKTEKDEKGKSFMILVKPLAEAAV*" gene 1486021..1486449 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" downshifts 1486406 /Source="Nicolas_upshifts" /id="D829" /incds=0 /nref=80 /ntot=232 /MaxReadThrough="4.50069" /MaxDrop="4.3098" /score="-9.99315734" /energy="-11.8" /TU="U1218,U1221" /idTUdmin="U1218" /TUdmin="-153" /isTUend="FALSE" S_feature 1486450..1487403 /Source="Nicolas_S_feature" /locus_tag="new_1538693_1539646" /HighExp="H2O2, dia15, Diami, Paraq, G180, G135, G150, dia5, Heat, LBGexp" /AntisenseName="yktD" /AntisenseCor="-1.5120906229522399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="0.117724" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S537" downshifts complement(1486525) /Source="Nicolas_upshifts" /id="D830" /incds=0 /nref=4 /ntot=85 /MaxReadThrough="0.88821" /MaxDrop="3.44773" /score="19.9363134" /energy="-12.8" /TU="NA" /idTUdmin="U1222" /TUdmin=0 /isTUend="TRUE" CDS complement(1486527..1487441) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_389352.1" /db_xref="EnsemblGenomes-Gn:BSU14690" /db_xref="EnsemblGenomes-Tr:CAB13342" /db_xref="GOA:Q45500" /db_xref="InterPro:IPR007213" /db_xref="InterPro:IPR011610" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11819" /db_xref="UniProtKB/Swiss-Prot:Q45500" /translation="MRKNESSLTSLISAFARAYHSRYDTPLIFDDFIAKDLINEKEFI DISKNMIQEISFFNKEIAERLQNDPEKILKWVAQIQLSPTPLARASYCEKVLHNELIL GAKQYVILGAGLDTFCFRHPELENSLQVFEVDHPATQQLKKNKLKDANLTIPGHLHFV PMDFTKTFSYDPLLDEGFKNTKTFFSLLGVSYYVTREENASLISNLFSHVPPGSSIVF DYADETLFTAKGTSNRVEHMVKMAAASGEPMKSCFTYQEIEHLLESSGLLIYEHLSPD DINDLFFSNRKDNLSAFETIHYIHAVKK*" gene complement(1486527..1487441) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" promotor_-10 complement(1487507..1487526) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1487515) /Source="Nicolas_upshifts" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" promotor_-35 complement(1487541..1487548) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1487793..1489358) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /EC_number="3.4.24.28" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2128597, 6090407, 8436952, 15205417, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2128597, 6090407, 8436952, 15205417, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral metalloprotease" /protein_id="NP_389353.1" /db_xref="EnsemblGenomes-Gn:BSU14700" /db_xref="EnsemblGenomes-Tr:CAB13343" /db_xref="GOA:P68736" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10448" /db_xref="UniProtKB/Swiss-Prot:P68736" /translation="MGLGKKLSVAVAASFMSLSISLPGVQAAEGHQLKENQTNFLSKN AIAQSELSAPNDKAVKQFLKKNSNIFKGDPSKRLKLVESTTDALGYKHFRYAPVVNGV PIKDSQVIVHVDKSDNVYAVNGELHNQSAAKTDNSQKVSSEKALALAFKAIGKSPDAV SNGAAKNSNKAELKAIETKDGSYRLAYDVTIRYVEPEPANWEVLVDAETGSILKQQNK VEHAAATGSGTTLKGATVPLNISYEGGKYVLRDLSKPTGTQIITYDLQNRQSRLPGTL VSSTTKTFTSSSQRAAVDAHYNLGKVYDYFYSNFKRNSYDNKGSKIVSSVHYGTQYNN AAWTGDQMIYGDGDGSFFSPLSGSLDVTAHEMTHGVTQETANLIYENQPGALNESFSD VFGYFNDTEDWDIGEDITVSQPALRSLSNPTKYNQPDNYANYRNLPNTDEGDYGGVHT NSGIPNKAAYNTITKLGVSKSQQIYYRALTTYLTPSSTFKDAKAALIQSARDLYGSTD AAKVEAAWNAVGL*" gene complement(1487793..1489358) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" promotor_-10 complement(1489393..1489412) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1489404) /Source="Nicolas_upshifts" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" promotor_-35 complement(1489426..1489433) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1489643..1491583 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" gene 1489643..1491583 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" CDS 1491573..1491842 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" gene 1491573..1491842 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" promotor_-35 1491808..1491812 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1491826..1491845 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1491839 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" CDS 1491842..1492363 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" gene 1491842..1492363 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" CDS 1492360..1492653 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" gene 1492360..1492653 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" CDS complement(1492693..1493304) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" gene complement(1492693..1493304) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" downshifts complement(1492707) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1493336..1493355) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1493345) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" promotor_-35 complement(1493370..1493373) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1493560) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" CDS complement(1493577..1493765) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" gene complement(1493577..1493765) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" downshifts complement(1493631) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(1493787..1493806) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1493804) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" promotor_-35 complement(1493819..1493826) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1493832..1493851 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1493839 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" CDS 1493878..1495716 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" gene 1493878..1495716 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" CDS 1495773..1496090 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" gene 1495773..1496090 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" downshifts 1496064 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" downshifts complement(1496139) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" CDS complement(1496146..1496355) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" gene complement(1496146..1496355) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" misc_feature complement(1496369..1496388) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1496384) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" CDS complement(1496438..1497067) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" gene complement(1496438..1497067) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" downshifts complement(1496469) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1496969..1496987) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1496975) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1496999..1497007) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1497102..1497113) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1497107) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" promotor_-35 1497119..1497124 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1497128..1497134) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1497140..1497158 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1497140 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" S_feature 1497141..1497221 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1497222..1498550 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" gene 1497222..1498550 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" S_feature complement(1498406..1498553) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1498449) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" S_feature 1498551..1499141 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1498554..1499039) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" gene complement(1498554..1499039) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" promotor_-10 complement(1499051..1499070) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1499079) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" promotor_-35 complement(1499085..1499092) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1499142..1500071 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" gene 1499142..1500071 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" misc_feature 1499656..1499675 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1499665 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" promotor_-35 1500095..1500098 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1500113..1500132 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1500121 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" CDS 1500169..1500450 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" gene 1500169..1500450 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" downshifts 1500439 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" promotor_-35 1500513..1500516 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1500529..1500655 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1500529 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" promotor_-10 1500534..1500540 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1500656..1501867 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" gene 1500656..1501867 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" promotor_-35 1501877..1501881 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1501896..1501915 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1501915 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" CDS 1501942..1505388 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" gene 1501942..1505388 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" promotor_-10 complement(1504954..1504972) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1504974) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1504988..1504993) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1505368 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" downshifts 1505413 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" downshifts complement(1505445) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" downshifts 1505457 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" CDS complement(1505791..1506711) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" gene complement(1505791..1506711) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" downshifts complement(1505797) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(1506751..1506770) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1506766) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" promotor_-35 complement(1506784..1506791) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1506846..1506853 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1506867..1506886 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1506868..1506973 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1506868 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" S_feature 1506975..1507065 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1506975 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" promotor_-35 1506981..1506984 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1506999..1507015 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1507066..1507983 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" gene 1507066..1507983 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" downshifts 1508012 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" upshifts 1508031 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" misc_feature 1508032..1508037 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1508091..1508096 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1508111..1508129 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1508119..1508222 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1508119 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" CDS 1508223..1509293 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" gene 1508223..1509293 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" CDS 1509326..1511194 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" gene 1509326..1511194 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" CDS 1511194..1511817 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" gene 1511194..1511817 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" CDS 1511820..1512152 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" gene 1511820..1512152 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" CDS 1512179..1513072 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" gene 1512179..1513072 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" downshifts 1513047 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" CDS complement(1513104..1513466) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" gene complement(1513104..1513466) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" downshifts complement(1513123) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" promotor_-35 1513459..1513463 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1513472..1513485 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1513490..1513509) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1513494..1513605 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1513494 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" upshifts complement(1513502) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" promotor_-35 complement(1513524..1513531) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1513606..1514052 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" gene 1513606..1514052 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" promotor_-35 1513638..1513645 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1513657..1513676 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1513662 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" promotor_-35 1514061..1514068 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1514082..1514101 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1514093 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" CDS 1514136..1515176 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" gene 1514136..1515176 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" promotor_-10 complement(1515099..1515117) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1515104) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1515133..1515138) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1515156 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" promotor_-35 1515340..1515349 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1515363..1515382 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1515377 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" CDS 1515408..1515806 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" gene 1515408..1515806 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" downshifts complement(1515412) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" CDS 1515822..1516061 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" gene 1515822..1516061 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" downshifts 1516040 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" promotor_-35 1516128..1516135 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1516146..1516165 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1516151 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" CDS 1516177..1516626 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" gene 1516177..1516626 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" downshifts 1516612 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" CDS 1516681..1516953 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" gene 1516681..1516953 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" S_feature complement(1516758..1516981) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1516956..1517076 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" gene 1516956..1517076 /gene="csfG" /locus_tag="BSU_misc_RNA_23" S_feature complement(1516983..1517106) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1517026) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" S_feature 1517077..1517182 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1517107..1517119) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1517114) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" promotor_-35 complement(1517134..1517140) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1517163..1517167 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1517183..1517202 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1517184..1517275 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1517184 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" CDS 1517276..1517830 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" gene 1517276..1517830 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" CDS 1517835..1518320 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" gene 1517835..1518320 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" downshifts 1518287 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" CDS complement(1518331..1519557) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" gene complement(1518331..1519557) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" S_feature 1518332..1519606 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1519558..1519659) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1519581..1519588 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1519600..1519619 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1519608..1519737 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1519608 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" promotor_-10 complement(1519654..1519672) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1519669) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" promotor_-35 complement(1519689..1519694) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1519738..1520520 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" gene 1519738..1520520 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" promotor_-35 1520300..1520306 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1520320..1520331 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1520331 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" CDS 1520522..1521547 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" gene 1520522..1521547 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" downshifts 1521431 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" CDS complement(1521564..1522811) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" gene complement(1521564..1522811) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" downshifts complement(1521591) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" promotor_-35 1522728..1522734 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1522748..1522759 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1522752 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" CDS complement(1522808..1522993) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" gene complement(1522808..1522993) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" promotor_-35 1522826..1522830 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1522846..1522865 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1522855..1522990 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1522855 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" promotor_-10 complement(1522884..1522903) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1522894) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" promotor_-35 complement(1522917..1522924) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1522961..1522968 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1522982..1523001 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1522992 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" CDS 1523021..1523539 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" gene 1523021..1523539 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" CDS 1523561..1523740 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" gene 1523561..1523740 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" downshifts 1523720 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" upshifts complement(1523763) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1523767..1523770) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1523821..1523826 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1523842..1523860 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1523843 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" CDS 1523886..1524467 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" gene 1523886..1524467 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" downshifts 1524468 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" CDS complement(1524524..1525006) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" gene complement(1524524..1525006) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" downshifts complement(1524543) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" downshifts 1524996 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" promotor_-10 complement(1525029..1525048) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1525048) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" promotor_-35 complement(1525062..1525069) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1525106..1525112 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1525124..1525143 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1525126 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" CDS 1525166..1526062 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" gene 1525166..1526062 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" CDS 1526133..1527752 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" gene 1526133..1527752 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" downshifts 1527724 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" promotor_-35 1527786..1527789 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1527804..1527877 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1527804..1527823 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1527804 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" downshifts complement(1527861) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" CDS 1527878..1528309 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" gene 1527878..1528309 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" CDS 1528379..1529314 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" gene 1528379..1529314 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" S_feature complement(1528981..1530433) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1529354..1529707 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" gene 1529354..1529707 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" CDS 1529704..1531854 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" gene 1529704..1531854 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" promotor_-10 complement(1530414..1530432) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1530433) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" promotor_-35 complement(1530447..1530453) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1531837 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" promotor_-35 1531909..1531914 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1531930..1531948 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1531930 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" CDS 1531971..1533911 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" gene 1531971..1533911 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" promotor_-35 1533707..1533713 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1533728..1533736 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1533734 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" downshifts 1533884 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" S_feature 1533929..1533996 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1533966..1533970 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1533986..1534005 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1533998..1534086 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1533998 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" CDS 1534087..1535571 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" gene 1534087..1535571 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" S_feature 1535572..1535682 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1535683..1536657 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" gene 1535683..1536657 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" CDS 1536658..1538013 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" gene 1536658..1538013 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" promotor_-35 1537837..1537842 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1537858..1537876 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1537868 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" CDS 1538074..1539174 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" gene 1538074..1539174 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" S_feature 1539175..1539296 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1539297..1540388 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" gene 1539297..1540388 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" promotor_-35 1539777..1539786 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1539799..1539814 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1539804 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" promotor_no_box 1539810..1539910 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1539870 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" CDS 1540420..1541331 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" gene 1540420..1541331 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" downshifts 1541349 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" CDS 1541461..1542252 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" gene 1541461..1542252 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" CDS 1542249..1542944 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" gene 1542249..1542944 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" CDS 1542967..1543674 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" gene 1542967..1543674 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" CDS 1543692..1544057 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" gene 1543692..1544057 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" promotor_-35 1543909..1543912 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1543928..1543947 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1543944 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" S_feature 1544058..1544230 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1544231..1545553 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" gene 1544231..1545553 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" upshifts complement(1544438) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1544442..1544446) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1544461..1544465) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1545589..1546737 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" gene 1545589..1546737 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" downshifts 1546711 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" S_feature 1546936..1547039 /Source="Nicolas_S_feature" /locus_tag="new_1599179_1599282" /HighExp="T5.0H, BC, T4.0H, T3.30H, T3.0H, S2, BT, M9-stat, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.953" /TUlongSig="SigA, SigWXY, SigA, Sig-" /TUlongPSig="0.989, 1, 1, 0.436" /label="S561" upshifts 1546936 /Source="Nicolas_upshifts" /id="U1273" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.953046953046953" /xcortree=486 /SigmaFactorBS="tttttatcattttcatatatatggaaattgaatgacatgaaa cgacaatatctgtaattcagATTGTCTACAGTTAATATACagcgatgttctgacaaac c" /listShort="S561, bpr" /GFF_Attribute="listLong" misc_feature 1546938..1546957 /Source="Nicolas_upshift_promotors" /id="U1273" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.953046953046953" /xcortree=486 /SigmaFactorBS="tttttatcattttcatatatatggaaattgaatgacatgaaa cgacaatatctgtaattcagATTGTCTACAGTTAATATACagcgatgttctgacaaac c" /listShort="S561, bpr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1547040..1551341 /gene="bpr" /locus_tag="BSU_15300" /old_locus_tag="BSU15300" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1368833, 1938892, 2106512, 2108961, 15205417, 15375126, 18194340, 18414485, 26497454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1368833, 1938892, 2106512, 2108961, 15205417, 15375126, 18194340, 18414485, 26497454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillopeptidase F" /protein_id="NP_389413.1" /db_xref="EnsemblGenomes-Gn:BSU15300" /db_xref="EnsemblGenomes-Tr:CAB13403" /db_xref="GOA:P16397" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR008757" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR012103" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR033857" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10233" /db_xref="UniProtKB/Swiss-Prot:P16397" /translation="MRKKTKNRLISSVLSTVVISSLLFPGAAGASSKVTSPSVKKELQ SAESIQNKISSSLKKSFKKKEKTTFLIKFKDLANPEKAAKAAVKKAKSKKLSAAKTEY QKRSAVVSSLKVTADESQQDVLKYLNTQKDKGNADQIHSYYVVNGIAVHASKEVMEKV VQFPEVEKVLPNEKRQLFKSSSPFNMKKAQKAIKATDGVEWNVDQIDAPKAWALGYDG TGTVVASIDTGVEWNHPALKEKYRGYNPENPNEPENEMNWYDAVAGEASPYDDLAHGT HVTGTMVGSEPDGTNQIGVAPGAKWIAVKAFSEDGGTDADILEAGEWVLAPKDAEGNP HPEMAPDVVNNSWGGGSGLDEWYRDMVNAWRAADIFPEFSAGNTDLFIPGGPGSIANP ANYPESFATGATDINKKLADFSLQGPSPYDEIKPEISAPGVNIRSSVPGQTYEDGWDG TSMAGPHVSAVAALLKQANASLSVDEMEDILTSTAEPLTDSTFPDSPNNGYGHGLVNA FDAVSAVTDGLGKAEGQVSVEGDDQEPPVYQHEKVTEAYEGGSLPLTLTAEDNVSVTS VKLSYKLDQGEWTEITAKRISGDHLKGTYQAEIPDIKGTKLSYKWMIHDFGGHVVSSD VYDVTVKPSITAGYKQDFETAPGGWVASGTNNNWEWGVPSTGPNTAASGEKVYGTNLT GNYANSANMNLVMPPIKAPDSGSLFLQFKSWHNLEDDFDYGYVFVLPEGEKNWEQAGV YNGKTSSWTDEEIDLSAYKGQNIQVMFNLQSDESIAKEGWYIDDVVLSDKSAGKTVKK NKLGVEKPSGKQKKKPVNPKKAKPSANTAVKHQNKAIQPQVLPLKAQVSVVETGKSTY SDQSTGQYTLKHKAGDYTLMAEAYGYQSKTQKVSLKTDQTTQANFTLEEMKKGTLKGT VINKTTGEPVTGASVYVVEDAAVEPAMTNDKGEYMLEAYEGAYTIKVAAPGYYSDEFS VELKGDVTKETALKPFVGYPGEIAYDDGTAENANSYFAAGNGWAVKMTLADGKDKGML TGGLFRFWDTEFPDPGGTEFKVEVYDATGKDGAPGKKIAGPFNAEALRNGEWTKVDLS SKGIMVDKDFYLVYIQSKPDPYSPGLAMDETGQNSGRNWQYIDGKWQPGDKADGNYMI RALVDYEAAVPEITSPTDKSYTNKDSVTVKGNASPGTTVHIYNGEKEAGETKAAADGT FHAGIILNKGENELTATASTDNGTTDASSPITVTLDQEKPELTLDNPKDGGKTNKETL TVKGAVSDDNLKDVKVNGKKATVADGSYSARILLENGRNEIKVIATDLAGNKTTKKTV IDVNFDKPVISGLIPGEDKNLKAGESVKIAFSSAEDLDATFTIRMPLTNARASVQNAT ELPLREISPGRYEGYWTATSSIKAKGAKVEVIVRDDYGNETRKTANGKLNMNTEN*" gene 1547040..1551341 /gene="bpr" /locus_tag="BSU_15300" /old_locus_tag="BSU15300" downshifts 1551338 /Source="Nicolas_upshifts" /id="D865" /incds=0 /nref=73 /ntot=169 /MaxReadThrough="0.90839" /MaxDrop="8.78054" /score="38.0577497" /energy="-11.4" /TU="NA" /idTUdmin="U1273" /TUdmin=1 /isTUend="TRUE" S_feature complement(1551349..1552491) /Source="Nicolas_S_feature" /locus_tag="new_1603592_1604734_c" /HighExp="S8, S6, S7, S5, LoTm, S4, B36, T5.0H, BT, B60" /AntisenseName="spoIIGA" /AntisenseCor="0.71080549463714104" /AntisenseRegPval="-42" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.579" /TUlongSig="NA" /TUlongPSig="NA" /label="S562" downshifts complement(1551391) /Source="Nicolas_upshifts" /id="D866" /incds=0 /nref=5 /ntot=22 /MaxReadThrough="2.36451" /MaxDrop="3.61596" /score="22.1321546" /energy="-9.6" /TU="NA" /idTUdmin="U1275" /TUdmin=0 /isTUend="TRUE" S_feature 1551469..1551535 /Source="Nicolas_S_feature" /locus_tag="new_1603712_1603778" /HighExp="M9-stat, T5.0H, S4, LoTm, T3.30H, T3.0H, B60, S3, S5, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S563" upshifts 1551471 /Source="Nicolas_upshifts" /id="U1274" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.282717282717283" /psig="0.534465534465534" /xcortree=966 /SigmaFactorBS="gcagatttccctgaaaaattgtattttcctctcaacattaat tgacagactttcccacagaGCTTGCTTTATACTTATGAAgcaagaaggggaacagcgt g" /listShort="S563, spoIIGA, sigE, S564, sigG, S565" /listLong="ylmA, NA, thiQ" misc_feature 1551472..1551491 /Source="Nicolas_upshift_promotors" /id="U1274" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.282717282717283" /psig="0.534465534465534" /xcortree=966 /SigmaFactorBS="gcagatttccctgaaaaattgtattttcctctcaacattaat tgacagactttcccacagaGCTTGCTTTATACTTATGAAgcaagaaggggaacagcgt g" /listShort="S563, spoIIGA, sigE, S564, sigG, S565" /listLong="ylmA, NA, thiQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature complement(1551489..1551501) /Source="Nicolas_upshift_promotors" /id="U1275" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.185814185814186" /xcortree=1053 /SigmaFactorBS="caaatgacatctaaatagattttcacatctgactcctttctt tcttgcctcacgctgttcCCCTTCTTGCTTCataagtataaagcaagctctgtgggaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1551501) /Source="Nicolas_upshifts" /id="U1275" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.185814185814186" /xcortree=1053 /SigmaFactorBS="caaatgacatctaaatagattttcacatctgactcctttctt tcttgcctcacgctgttcCCCTTCTTGCTTCataagtataaagcaagctctgtgggaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1551536..1552465 /gene="spoIIGA" /locus_tag="BSU_15310" /old_locus_tag="BSU15310" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7585939, 7729420, 9573195, 9663680, 10498732, 15849754, 16850406, 18378688, 21362630, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7585939, 7729420, 9573195, 9663680, 10498732, 15849754, 16850406, 18378688, 21362630, 22111992; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease processing pro-sigma-E" /protein_id="NP_389414.1" /db_xref="EnsemblGenomes-Gn:BSU15310" /db_xref="EnsemblGenomes-Tr:CAB13405" /db_xref="GOA:P13801" /db_xref="InterPro:IPR005081" /db_xref="SubtiList:BG10234" /db_xref="UniProtKB/Swiss-Prot:P13801" /translation="MKIYLDVIWLLNFCFDALLLLLTAFILKRHVKKRRLVGGAFIGS SIVLLMFTPFSPIVEHPAGKLAFSVVIVVVTFGFKRFRFFFQNLFSFYFATFLMGGGI IGAHSLLQSNSIVQNGVMITNQTGFGDPISWLFIVGGFPALWFFSKRRIEDIETKNIQ YEERVSVQADLGSQTLHVRGLIDSGNQLYDPLTKTPVMIIYIDKLEPIFGTAETMIIR NTDPLEAIEQLDDSFRFLDKMRLIPYRGVGQQNQFLLCVKPDHVTIMTKEEMISADKC LIGISTTKLSADGEFDAIIHPKMLSGKAVKHVS*" gene 1551536..1552465 /gene="spoIIGA" /locus_tag="BSU_15310" /old_locus_tag="BSU15310" promotor_-10 complement(1552480..1552499) /Source="Nicolas_upshift_promotors" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1552493) /Source="Nicolas_upshifts" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" promotor_-35 complement(1552514..1552517) /Source="Nicolas_upshift_promotors" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1552528..1553247 /gene="sigE" /locus_tag="BSU_15320" /old_locus_tag="BSU15320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1581961, 7708009, 8464402, 15187183, 20802044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1581961, 7708009, 8464402, 15187183, 20802044; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-29 factor (sigma-E)" /protein_id="NP_389415.2" /db_xref="EnsemblGenomes-Gn:BSU15320" /db_xref="EnsemblGenomes-Tr:CAB13406" /db_xref="GOA:P06222" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014200" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG10235" /db_xref="UniProtKB/Swiss-Prot:P06222" /translation="MKKLKLRLTHLWYKLLMKLGLKSDEVYYIGGSEALPPPLSKDEE QVLLMKLPNGDQAARAILIERNLRLVVYIARKFENTGINIEDLISIGTIGLIKAVNTF NPEKKIKLATYASRCIENEILMYLRRNNKIRSEVSFDEPLNIDWDGNELLLSDVLGTD DDIITKDIEANVDKKLLKKALEQLNEREKQIMELRFGLVGEEEKTQKDVADMMGISQS YISRLEKRIIKRLRKEFNKMV*" gene 1552528..1553247 /gene="sigE" /locus_tag="BSU_15320" /old_locus_tag="BSU15320" S_feature 1553248..1553337 /Source="Nicolas_S_feature" /locus_tag="new_1605491_1605580" /HighExp="T5.0H, S3, M9-stat, T4.0H, S4, LoTm, S2, B60, B36, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S564" promotor_-35 1553321..1553327 /Source="Nicolas_upshift_promotors" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1553339 /Source="Nicolas_upshifts" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" promotor_-10 1553341..1553352 /Source="Nicolas_upshift_promotors" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1553387..1554169 /gene="sigG" /locus_tag="BSU_15330" /old_locus_tag="BSU15330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15187183, 15256570, 16166546, 16497325, 17015665, 21935351" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187183, 15256570, 16166546, 16497325, 17015665, 21935351; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma factor(sigma-G)" /protein_id="NP_389416.1" /db_xref="EnsemblGenomes-Gn:BSU15330" /db_xref="EnsemblGenomes-Tr:CAB13407" /db_xref="GOA:P19940" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014212" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10236" /db_xref="UniProtKB/Swiss-Prot:P19940" /translation="MSRNKVEICGVDTSKLPVLKNEEMRKLFRQLQDEGDDSAREKLV NGNLRLVLSVIQRFNNRGEYVDDLFQVGCIGLMKSIDNFDLSHNVKFSTYAVPMIIGE IRRYLRDNNPIRVSRSLRDIAYKALQVRERLISETSKEPTAEDIAKVLEVPHEEIVFA LDAIQDPVSLFEPIYNDGGDPIYVMDQISDERNTDSQWIEELALKEGMRRLNDREKMI LRKRFFQGKTQMEVAEEIGISQAQVSRLEKAAIKQMNKNIHQ*" gene 1553387..1554169 /gene="sigG" /locus_tag="BSU_15330" /old_locus_tag="BSU15330" S_feature 1554170..1554258 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1554223..1554230 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1554243..1554262 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1554260 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" CDS 1554317..1555111 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" gene 1554317..1555111 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" promotor_-35 1555029..1555032 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1555047..1555066 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1555055 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" misc_RNA 1555124..1555225 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene 1555124..1555225 /gene="tswE" /locus_tag="BSU_misc_RNA_24" downshifts 1555212 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" CDS 1555313..1556593 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" gene 1555313..1556593 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" misc_feature complement(1556534..1556550) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1556539) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1556614..1556619 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1556635..1556653 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1556639 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" CDS 1556676..1556921 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" gene 1556676..1556921 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" promotor_-35 1556837..1556845 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1556856..1556874 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1556864 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" S_feature 1556922..1557032 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1557024..1557043 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1557034 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" CDS 1557084..1557920 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" gene 1557084..1557920 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" CDS 1557927..1558619 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" gene 1557927..1558619 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" CDS 1558616..1559071 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" gene 1558616..1559071 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" CDS 1559078..1559350 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" gene 1559078..1559350 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" downshifts 1559339 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" CDS 1559411..1560184 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" gene 1559411..1560184 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" promotor_-35 1559900..1559907 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1559921..1559939 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1559944 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" S_feature 1560185..1560277 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1560278..1560772 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" gene 1560278..1560772 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" promotor_-35 1560785..1560792 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1560806..1560825 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1560813 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" misc_RNA 1560835..1561061 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" gene 1560835..1561061 /gene="iswA" /locus_tag="BSU_misc_RNA_25" downshifts 1561028 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" CDS 1561114..1563879 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" gene 1561114..1563879 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" downshifts 1563870 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" downshifts complement(1563925) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" promotor_-35 1563960..1563966 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1563981..1563992 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1563981 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" CDS 1564024..1564398 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" gene 1564024..1564398 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" promotor_-35 1564430..1564434 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1564449 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" promotor_-10 1564450..1564469 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1564501..1564965 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" gene 1564501..1564965 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" CDS 1564967..1565878 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" gene 1564967..1565878 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" promotor_-35 1565873..1565880 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1565895..1565914 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1565909 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" misc_RNA 1565918..1566034 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" gene 1565918..1566034 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" CDS 1566061..1566606 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" gene 1566061..1566606 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" downshifts complement(1566255) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" downshifts 1566597 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" misc_RNA 1566610..1566727 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" gene 1566610..1566727 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" CDS 1566780..1568087 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" gene 1566780..1568087 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" misc_RNA 1568088..1568202 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" gene 1568088..1568202 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" CDS 1568233..1569147 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" gene 1568233..1569147 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" CDS 1569131..1570417 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" gene 1569131..1570417 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" CDS 1570414..1571508 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" gene 1570414..1571508 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" CDS 1571493..1574708 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" gene 1571493..1574708 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" CDS 1574705..1575475 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" gene 1574705..1575475 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" CDS 1575475..1576410 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" gene 1575475..1576410 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" CDS 1576379..1577098 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" gene 1576379..1577098 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" CDS 1577077..1577727 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" gene 1577077..1577727 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" downshifts 1577729 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" S_feature 1577774..1577846 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1577826..1577833 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1577847..1577866 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1577848 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" misc_RNA 1577872..1577977 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" gene 1577872..1577977 /gene="mswE" /locus_tag="BSU_misc_RNA_29" S_feature 1577978..1578138 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1578139..1578840 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" gene 1578139..1578840 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" CDS 1578852..1579916 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" gene 1578852..1579916 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" CDS 1579965..1581113 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" gene 1579965..1581113 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" upshifts complement(1580054) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1580066..1580070) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1580088..1580089) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1581126..1581719 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" gene 1581126..1581719 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" S_feature 1581720..1581817 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1581818..1582591 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" gene 1581818..1582591 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" promotor_-35 1582496..1582503 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1582518..1582537 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1582519 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" CDS 1582594..1583379 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" gene 1582594..1583379 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" CDS 1583360..1583848 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" gene 1583360..1583848 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" downshifts 1583828 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" downshifts complement(1583875) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" CDS complement(1583888..1585606) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" gene complement(1583888..1585606) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" promotor_-10 complement(1585628..1585647) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1585642..1585647 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1585642) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" promotor_-35 complement(1585660..1585665) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1585663..1585681 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1585667 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" CDS 1585722..1588394 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" gene 1585722..1588394 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" promotor_-10 complement(1587127..1587146) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1587138) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1587161..1587168) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1588400..1588419 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1588403..1588476 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1588403 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" CDS 1588477..1589352 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" gene 1588477..1589352 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" CDS 1589429..1589698 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" gene 1589429..1589698 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" misc_feature complement(1589509..1589513) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1589514) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1589706..1590320 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" gene 1589706..1590320 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" CDS 1590324..1590527 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" gene 1590324..1590527 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" downshifts 1590516 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" CDS 1590608..1591828 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" gene 1590608..1591828 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" S_feature complement(1591667..1592242) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1591825..1594242 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" gene 1591825..1594242 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" promotor_-10 complement(1592238..1592256) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1592242) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" promotor_-35 complement(1592270..1592276) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1594093..1594097 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1594113..1594132 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1594124 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" CDS 1594269..1594751 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" gene 1594269..1594751 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" CDS 1594756..1595709 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" gene 1594756..1595709 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" CDS 1595696..1597039 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" gene 1595696..1597039 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" CDS 1597043..1598134 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" gene 1597043..1598134 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" CDS 1598141..1598905 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" gene 1598141..1598905 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" downshifts 1598194 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" CDS 1598899..1600845 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" gene 1598899..1600845 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" promotor_-35 1600754..1600760 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1600774..1600792 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1600790 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" CDS 1600860..1601756 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" gene 1600860..1601756 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" CDS 1601761..1602414 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " gene 1601761..1602414 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" promotor_-35 1602412..1602421 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1602435..1602454 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1602440 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" CDS 1602487..1603131 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" gene 1602487..1603131 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" promotor_-35 1602892..1602898 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1602909 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" promotor_-10 1602913..1602931 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1603022..1603027 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1603043..1603061 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1603056 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" S_feature 1603132..1603202 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1603203..1603283 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" gene 1603203..1603283 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" downshifts 1603298 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" S_feature 1603343..1603715 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1603356..1603544) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" gene complement(1603356..1603544) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" downshifts complement(1603372) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" downshifts complement(1603418) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" S_feature complement(1603545..1603637) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1603619..1603638) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1603637) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" promotor_-35 complement(1603654..1603657) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1603688..1603695 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1603710..1603728 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1603717 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" promotor_-35 1603756..1603759 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1603774..1603793 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1603782 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" CDS 1603821..1604183 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" gene 1603821..1604183 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" downshifts complement(1604034) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" CDS 1604199..1605860 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" gene 1604199..1605860 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" S_feature 1605861..1605950 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1605923..1605930 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1605944..1605963 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1605952 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" CDS 1605999..1606661 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" gene 1605999..1606661 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" CDS 1606687..1607589 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" gene 1606687..1607589 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" CDS 1607567..1609615 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" gene 1607567..1609615 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" promotor_-35 1609651..1609658 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1609673..1609692 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1609679 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" CDS 1609724..1610290 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" gene 1609724..1610290 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" CDS 1610304..1611305 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " gene 1610304..1611305 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" CDS 1611324..1612277 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" gene 1611324..1612277 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" CDS 1612270..1613010 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" gene 1612270..1613010 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" promotor_-35 1613041..1613045 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1613061..1613080 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1613066 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" CDS 1613094..1613327 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" gene 1613094..1613327 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" downshifts 1613308 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" promotor_no_box 1613336..1613436 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1613396..1613466 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1613396 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" CDS 1613467..1614216 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" gene 1613467..1614216 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" downshifts 1614188 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" promotor_-35 1614258..1614264 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1614276..1614295 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1614298 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" CDS 1614317..1617877 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" gene 1614317..1617877 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" S_feature complement(1617811..1618881) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1617897..1618886 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" gene 1617897..1618886 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" downshifts 1618873 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" CDS complement(1618923..1619408) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" gene complement(1618923..1619408) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" downshifts complement(1618926) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" promotor_-10 complement(1619430..1619448) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1619446) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" promotor_-35 complement(1619462..1619469) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1619511..1619517 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1619532..1619551 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1619534 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1619585..1619917 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" gene 1619585..1619917 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" downshifts complement(1619588) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" CDS 1619931..1621271 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" gene 1619931..1621271 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" S_feature 1621272..1621376 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1621377..1621649 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" gene 1621377..1621649 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" CDS 1621649..1621894 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" gene 1621649..1621894 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" downshifts 1621866 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" S_feature 1621911..1622015 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1622016..1622402 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" gene 1622016..1622402 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" CDS 1622407..1622931 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" gene 1622407..1622931 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" CDS 1622928..1623659 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" gene 1622928..1623659 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" promotor_-35 1623665..1623672 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1623686..1623705 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1623690 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" misc_RNA 1623738..1623779 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" gene 1623738..1623779 /locus_tag="BSU_misc_RNA_30" CDS 1623799..1624146 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" gene 1623799..1624146 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" downshifts 1624148 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" promotor_-35 1624201..1624207 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1624220..1624288 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1624220 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" promotor_-10 1624221..1624240 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1624289..1625137 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" gene 1624289..1625137 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" promotor_-35 1625158..1625165 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1625178..1625196 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1625188 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1625208..1625975 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" gene 1625208..1625975 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" CDS 1626007..1627737 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" gene 1626007..1627737 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" upshifts complement(1627244) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1627245..1627264) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1627279..1627286) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1627734..1628015 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" gene 1627734..1628015 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" downshifts 1627847 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" S_feature 1628016..1628135 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1628107..1628114 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1628128..1628147 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1628137 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1628188..1629345 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" gene 1628188..1629345 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" promotor_no_box complement(1628260..1628360) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1628300) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1629374..1630276 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" gene 1629374..1630276 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" downshifts 1630266 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" CDS 1630337..1631230 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" gene 1630337..1631230 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" promotor_-35 1631236..1631243 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1631258..1631277 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1631265..1631417 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1631265 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1631418..1633493 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" gene 1631418..1633493 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" downshifts 1633463 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" promotor_-35 1633525..1633530 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1633537 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" promotor_-10 1633546..1633564 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1633569..1634876 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" gene 1633569..1634876 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" promotor_-35 1634882..1634886 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1634903..1634922 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1634913 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1634944..1635858 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" gene 1634944..1635858 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" promotor_-35 1634983..1634987 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1635000 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" promotor_-10 1635003..1635022 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1635871..1636416 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" gene 1635871..1636416 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" CDS 1636433..1637836 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" gene 1636433..1637836 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" CDS 1637876..1638655 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" gene 1637876..1638655 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" downshifts 1638630 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" downshifts 1638674 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" promotor_-35 1638775..1638782 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1638795..1638813 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1638806..1638959 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1638806 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" promotor_-35 1638934..1638941 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1638956..1638975 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1638961 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1639035..1639424 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" gene 1639035..1639424 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" CDS 1639424..1639876 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" gene 1639424..1639876 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" CDS 1639887..1640207 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133968, 1551848, 1905667, 2544561, 9161424, 11133968, 15136044; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal body protein" /protein_id="NP_389502.1" /db_xref="EnsemblGenomes-Gn:BSU16200" /db_xref="EnsemblGenomes-Tr:CAB13493" /db_xref="GOA:P24502" /db_xref="InterPro:IPR001624" /db_xref="SubtiList:BG10239" /db_xref="UniProtKB/Swiss-Prot:P24502" /translation="MINAISPFQVQNTQNTQNATNQVNNSQKTDSSNQTSFSELLKNS ISSLNESQVASDNMTNALAAGKDVNLDEVMIAAQKASISLTAATEFRNKAVEAYQEIM RMQM*" gene 1639887..1640207 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" downshifts complement(1640202) /Source="Nicolas_upshifts" /id="D895" /incds=0 /nref=1 /ntot=83 /MaxReadThrough="1.38909" /MaxDrop="2.66249" /score="0.0645368779" /energy="-7.4" /TU="NA" /idTUdmin="U1325" /TUdmin=2684 /isTUend="FALSE" CDS 1640253..1641863 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 11133968, 22670715, 24970213, 28089452; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body M-ring protein" /protein_id="NP_389503.1" /db_xref="EnsemblGenomes-Gn:BSU16210" /db_xref="EnsemblGenomes-Tr:CAB13494" /db_xref="GOA:P23447" /db_xref="InterPro:IPR000067" /db_xref="InterPro:IPR006182" /db_xref="InterPro:IPR013556" /db_xref="InterPro:IPR021157" /db_xref="SubtiList:BG10240" /db_xref="UniProtKB/Swiss-Prot:P23447" /translation="MNRTLMQMKNKTSEFWKNRSKLQKILMVSALAAIIIIGIIISVF ASNSKMAPLYKDLSAEEAGQIKEELDAKKVPNELSNGGTVISVPEDQVDSLKVQMAAE GLPKTGSIDYSFFGQNAGFGLTDNEFDMVKVKATQTELSNLINEMDGIKNSKVMINLP KDAVFVGEEQSAASASIVLQIQPGYTLDQSQINGLYHLVSKSVPNLKEDNIVIMDQNS TYYDKSDSDAGSYADSYSSQQGIKSQVEKDIQKHVQSLLGTMMGQDKVVVSVTADIDF TKENRTEDIVEPVDKENMEGIAVSAEKVSETYQGDGAANGGTAGTGEEDVTNYKADGE NTESGNYEKNSNKINYEVNRIHKEIAESPYKVRDLGIQVMVEPPDAKNTASLSTERQD DIQKILSTVVRTSLDKDETQNQNLSDADINNKIVVSVQPFDGKVNLDTNTEESSGIPL WAYIVGGVLIAAIIVLIIMLIRKKRAQEDEFEEYEYEVPQEPINLPDINEEENETAES VRRKQLEKMAKDKPEDFAKLLRSWLAED*" gene 1640253..1641863 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" CDS 1641876..1642892 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" /function="16.5: Explore" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 10440379, 11133968, 28089452; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389504.1" /db_xref="EnsemblGenomes-Gn:BSU16220" /db_xref="EnsemblGenomes-Tr:CAB13495" /db_xref="GOA:P23448" /db_xref="InterPro:IPR000090" /db_xref="InterPro:IPR011002" /db_xref="InterPro:IPR023087" /db_xref="InterPro:IPR028263" /db_xref="InterPro:IPR032779" /db_xref="SubtiList:BG10241" /db_xref="UniProtKB/Swiss-Prot:P23448" /translation="MARRDQDKLTGKQKAAILMISLGLDVSASVYKHLTDEEIERLTL EISGVRSVDHQKKDEIIEEFHNIAIAQDYISQGGLSYARQVLEKALGEDKAENILNRL TSSLQVKPFDFARKAEPEQILNFIQQEHPQTMALILSYLDPVQAGQILSELNPEVQAE VARRIAVMDRTSPEIINEVERILEQKLSSAFTQDYTQTGGIEAVVEVLNGVDRGTEKT ILDSLEIQDPDLAEEIKKRMFVFEDIVTLDNRAIQRVIRDVENDDLLLSLKVASEEVK EIVFNNMSQRMVETFKEEMEFMGPVRLKDVEEAQSRIVSIVRKLEEAGEIVIARGGGD DIIV*" gene 1641876..1642892 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" S_feature 1642893..1643010 /Source="Nicolas_S_feature" /locus_tag="new_1695136_1695253" /HighExp="Lbstat, C90, M0t90, M40t90, Lbtran, C30, LPhT, GM 90, M40t45, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.998, 1, 0.998" /TUlongSig="SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.994, 1, 0.999, 1, 1, 1" /label="S585" promotor_no_box complement(1642956..1643056) /Source="Nicolas_upshift_promotors" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1642996) /Source="Nicolas_upshifts" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1643011..1643637 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" /function="16.6: Maintain" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1828465, 12217691, 16522800, 17002279, 26916245; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar export apparatus subunit of cytoplasmic ATPase" /protein_id="NP_389505.2" /db_xref="EnsemblGenomes-Gn:BSU16230" /db_xref="EnsemblGenomes-Tr:CAB13496" /db_xref="GOA:P23449" /db_xref="InterPro:IPR018035" /db_xref="InterPro:IPR022524" /db_xref="SubtiList:BG10242" /db_xref="UniProtKB/Swiss-Prot:P23449" /translation="MARVKEEADRISEQANSHIENIRRQIEQEKNDWAAEKQKLIEEA KAEGFEQGVALGKAEAMKQYAELIGQANSITEMSRKAVEDKLEDANEEIVELAVALAK KVWQQKSDDKEAFLLLVQQVINEVKEYDDISIYVDPYYYETIFQQKDEIQQLLYKECR LGIYADEKAQKGTCYIETPFGRVDASVDTQLMQLKDKLLTALEAGAAE*" gene 1643011..1643637 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" CDS 1643634..1644950 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" /EC_number="3.6.3.14" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787361, 16113269, 16780875, 17002279, 26916245; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="flagellar-specific ATPase subunit of export apparatus" /protein_id="NP_389506.2" /db_xref="EnsemblGenomes-Gn:BSU16240" /db_xref="EnsemblGenomes-Tr:CAB13497" /db_xref="GOA:P23445" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000225" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005714" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR022425" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032463" /db_xref="SubtiList:BG10243" /db_xref="UniProtKB/Swiss-Prot:P23445" /translation="MKTQSLIDCIEMTDSYKRYGKVKRVIGLMIESKGPASSIGDLCL IYAKGQSGKVIKAEVVGFQEENILLMPYLEAASIAPGSIVEATGESLRVKVGTGLIGQ VIDAFGEPLDGKLLPKGLSPVSTEQSPPNPMKRPPIREKMGVGVRSIDSLLTVGKGQR IGIFAGSGVGKSTLMGMIAKQTEADLNVIALVGERGREVREFIEKDLGKEGLKRSIVV VATSDQPALMRLKAAYTATAIAEYFRDKGQNVMFMMDSVTRVAMAQREIGLAAGEPPT TKGYTPSVFAILPRLLERTGANEHGTITAFYTVLVDGDDMNEPIADTVRGILDGHIVL DRALANKGQFPAVNVLKSISRVMSNISTKQHLDAANKFRELLSTYQNSEDLINIGAYK RGSSREIDEAIQFYPQLIQFLKQGTDEPALLEESIAALTSLTGNEE*" gene 1643634..1644950 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" CDS 1644953..1645396 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17088562, 26916245, 26984495, 27647891; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar synthesis rod subunit of export ATPase" /protein_id="NP_389507.1" /db_xref="EnsemblGenomes-Gn:BSU16250" /db_xref="EnsemblGenomes-Tr:CAB13498" /db_xref="GOA:P20487" /db_xref="InterPro:IPR012823" /db_xref="SubtiList:BG10245" /db_xref="UniProtKB/Swiss-Prot:P20487" /translation="MAYQFRFQKLLELKENEKDQSLSEYQQSVSEFENVAEKLYENMS KKELLEQNKEKKLKSGMSVQEMRHYQQFVSNLDNTIYHYQKLVIMKRNQMNQKQEILT EKNIEVKKFEKMREKQFKMFALEDKAAEMKEMDDISIKQFMIQGH*" gene 1644953..1645396 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" CDS 1645408..1646022 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17586671, 22307758; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative kinesin-like protein" /protein_id="NP_389508.2" /db_xref="EnsemblGenomes-Gn:BSU16260" /db_xref="EnsemblGenomes-Tr:CAB13499" /db_xref="GOA:P23454" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR011002" /db_xref="SubtiList:BG10246" /db_xref="UniProtKB/Swiss-Prot:P23454" /translation="MSGKKKESGKFRSVLLIIILPLMFLLIAGGIVLWAAGINVLKPI QDAAAKTPVLKELVPETENKKGAASSKDSSNTAALEKTIKDQKSEISILNKDLETSKS EIDRLNQKIRSLEKTAEDQKKSSEDHTEGSADSKASSENDKVISVYKSMDSGKAAKII AQLKEQEALKILNGLSKKQLADILAKMTPEQAATYTEKIAASQE*" gene 1645408..1646022 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" CDS 1646035..1647498 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16630628, 16949608, 28557186; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook-length control protein (ruler)" /protein_id="NP_389509.2" /db_xref="EnsemblGenomes-Gn:BSU16270" /db_xref="EnsemblGenomes-Tr:CAB13500" /db_xref="GOA:P23451" /db_xref="InterPro:IPR001635" /db_xref="InterPro:IPR021136" /db_xref="SubtiList:BG10247" /db_xref="UniProtKB/Swiss-Prot:P23451" /translation="MKLLELAGPLLQTTTGSAAKNMKSSQGVFQNWLMSEAGLKELSE QGKGTPNSEDQLLADALKKIGEWLNASPEDQDKQNADLLQTLSKLTGKQLDANALQML QNLLQAVESKMSGGTDQLLTETEKIFSEAKTALSANDSASDINGALKSDKEQSNQENE VSEPAKELIYIQMFISQLVEGNKLTDLGNGNEAHAIYQNGDQFLSALEKKGVSQQLIQ DLKQQIFTKAESSSKLYSMTASELKSFQSLMDQMSMLPQKGTKEWSLAESQLKAFLLS KSSESSQDFGKSVLTPLSQSSSSKNASDVSGSIQPVDSKSGLQMLFSGYRGIGGVQTL DLQQMSSDIPNAETKTVADQVINAWKQMKYTPFGRSTGSFTIRLNPEHLGFVTIKLTN ENGMFQSKIIASSQSAKELLEQHLPQLKQSLPNMAVQIDRFTLPVQSGDQPIYGQLAD EQKQQQEGQRQQRQKKQSNDFGDLLDEVSMVEMEEEE*" gene 1646035..1647498 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" CDS 1647495..1647917 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8157595, 14563871, 24748615; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook capping protein" /protein_id="NP_389510.1" /db_xref="EnsemblGenomes-Gn:BSU16280" /db_xref="EnsemblGenomes-Tr:CAB13501" /db_xref="GOA:P23455" /db_xref="InterPro:IPR005648" /db_xref="SubtiList:BG10248" /db_xref="UniProtKB/Swiss-Prot:P23455" /translation="MTSISSEYKLPEKTNTVSTNNSSLGKDEFLKILMTQVQNQDPLN PIDDKEFISQMATFSSLEQMMNLNTTMTQFVENQDPFTTYVDWMGKEVSWTDGKSATD KTGTVSSVKHFKGNYYLVLDDGTEISPANVMSVGQSSK*" gene 1647495..1647917 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" CDS 1647939..1648733 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15502333, 15510139, 27759043, 28120828, 28429800; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook protein" /protein_id="NP_389511.2" /db_xref="EnsemblGenomes-Gn:BSU16290" /db_xref="EnsemblGenomes-Tr:CAB13502" /db_xref="GOA:P23446" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR012836" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10249" /db_xref="UniProtKB/Swiss-Prot:P23446" /translation="MLRSLYSGISGMKNFQTKLDVIGNNIANVNTVGFKKSRVTFKDM VSQTIAGGSAAGATIGGTNSKQIGLGSSSGTIDTIHSTSATQSTGRTLDLAIDGDGYF RIDTGDGTAYTRAGNFYLDNTGTLVTGDGYHVLNMNGGTIKIPTDAQSFSIGSDGKVS IVDAEGKTQDGGQIGIVTFANSDGLDKIGSNLYRESLNSGTASAANQPGDGGTGALKS GFLEMSNVDLTDEFTEMIVAQRGFQSNSKIITTSDEILQELVNLKR*" gene 1647939..1648733 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" CDS 1648773..1648988 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9168127, 29061663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9168127, 29061663; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar power transducer required for swarming" /protein_id="YP_003097728.1" /db_xref="EnsemblGenomes-Gn:BSU16299" /db_xref="EnsemblGenomes-Tr:CAX52619" /db_xref="InterPro:IPR009384" /db_xref="UniProtKB/Swiss-Prot:C0H412" /translation="MIKVTRLNGQPFTLNALFIEQIECFPDTTITLSNGKKFVVKEDE EAVLEKIAAFYRKIQIFAMDQGIEEPE*" gene 1648773..1648988 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" CDS 1648985..1649407 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" /function="16.5: Explore" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10439416, 12787361, 16166542, 23264580, 25714720, 28717192; Product type f : factor" /codon_start=1 /transl_table=11 /product="flagellar basal-body (stator) associated protein" /protein_id="NP_389512.1" /db_xref="EnsemblGenomes-Gn:BSU16300" /db_xref="EnsemblGenomes-Tr:CAB13503" /db_xref="GOA:P23452" /db_xref="InterPro:IPR005503" /db_xref="SubtiList:BG10250" /db_xref="UniProtKB/Swiss-Prot:P23452" /translation="MKKKLMIILLIILIVIGALGAAAYFVLGGKSEKSEAKKSIDEIV ASSVDVEEITTNLKSDNIIRLAIKLETDSDKSKEELEKRDFQVKDAVISLLADTNADQ IEGDKGKETFKKELKDKINSYLQEGKVEKVYITSFNLQ*" gene 1648985..1649407 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" CDS 1649441..1650439 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7787061, 16547037, 16796690, 16882724, 17015643, 17050923, 22720735, 28625846; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389513.1" /db_xref="EnsemblGenomes-Gn:BSU16310" /db_xref="EnsemblGenomes-Tr:CAB13504" /db_xref="GOA:P23453" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR001689" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10251" /db_xref="UniProtKB/Swiss-Prot:P23453" /translation="MSGEVLSQNEIDALLSAISTGEMDAEELKKEEKEKKVKVYDFKR ALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIHISVSSVDQVPYEEFIRSIPNMT ILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGIGISHNKVDSLTEIETKIISNLFEN ALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCI PHIVLEPLIPKLSVHYWMQSDRNEPKPEETKSLEKRIMTAQIPVVAELGTSELTIEEF LSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQILDHDIRGEQDGE*" gene 1649441..1650439 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" CDS 1650429..1651565 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing phosphatase" /protein_id="NP_389514.1" /db_xref="EnsemblGenomes-Gn:BSU16320" /db_xref="EnsemblGenomes-Tr:CAB13505" /db_xref="GOA:P24073" /db_xref="InterPro:IPR001172" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR012826" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10252" /db_xref="UniProtKB/Swiss-Prot:P24073" /translation="MENNRLSQDEIDALLNGTGSTLDEPEIPEVDDLSEMERDAIGEI GNISFGSSATALSTLLNQKVDITTPSVTVIPRSKISDAFPEPYVAIEVNYTEGFSGSN LLVVEQSDAAIIADLMIGGDGKGADPSLGEIHLSAVQEAMNQMMGSAATSMSTVFSKK IDISPPRVELLDVTEEKGTDRIPDDEMLVKVSFNLKVGELIDSSIMQLYPLTFAKDLI SSLMNSESAEEEETVQPEVTYEQPKEPVTPEPRIEPKQQQQPPKRQGTAKKAAPVQVS PVEFSAFDPNEAVQAPIHNLDMLLDIPLSITVELGRTKRSVKEILELSAGSIIELDKL AGEPVDILVNQRIVAKGEVVVIEENFGVRVTDILSQAERINNLK*" gene 1650429..1651565 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" CDS 1651591..1651953 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10196193, 12864845, 12920116, 14749334, 23226535, 28542702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10196193, 12864845, 12920116, 14749334, 23226535, 28542702; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of chemotaxis and motility" /protein_id="NP_389515.1" /db_xref="EnsemblGenomes-Gn:BSU16330" /db_xref="EnsemblGenomes-Tr:CAB13506" /db_xref="GOA:P24072" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG10258" /db_xref="UniProtKB/Swiss-Prot:P24072" /translation="MAHRILIVDDAAFMRMMIKDILVKNGFEVVAEAENGAQAVEKYK EHSPDLVTMDITMPEMDGITALKEIKQIDAQARIIMCSAMGQQSMVIDAIQAGAKDFI VKPFQADRVLEAINKTLN*" gene 1651591..1651953 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" CDS 1651968..1652627 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10791024, 1597417, 16513753, 24204316; Product type r: regulator" /codon_start=1 /transl_table=11 /product="flagellar regulatory protein" /protein_id="NP_389516.1" /db_xref="EnsemblGenomes-Gn:BSU16340" /db_xref="EnsemblGenomes-Tr:CAB13507" /db_xref="GOA:P35536" /db_xref="InterPro:IPR022781" /db_xref="SubtiList:BG10259" /db_xref="UniProtKB/Swiss-Prot:P35536" /translation="MKKSQYFIVFICFFVLFSVHPIAAAAADSDNSTVNEWFQKKDEK TADQSEQKKEKTTKTADETEGAAAPSVSAFDFVKMIFALLFVIVLIYGLVKLMNKRNR LLKPFQYVENIGGTSVGQNRSIQLIKVGKSVLVVGVGETIQLLKEIEDEKEIEVILSQ HEEAMSSKIEWQKFVKPLKSSEHQPQQKLPSFSKALKEQLEELKQNRSEGKKKGPRHH E*" gene 1651968..1652627 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" CDS 1652620..1653285 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" /function="16.3: Control" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15516571, 15849754, 16850406, 22720735, 26244495, 27855178, 28559296; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389517.1" /db_xref="EnsemblGenomes-Gn:BSU16350" /db_xref="EnsemblGenomes-Tr:CAB13508" /db_xref="GOA:P35528" /db_xref="InterPro:IPR005837" /db_xref="InterPro:IPR005838" /db_xref="SubtiList:BG10260" /db_xref="UniProtKB/Swiss-Prot:P35528" /translation="MNEFINIFSSSDPENVSSTVKLLLLLTVFSVAPGILILMTCFTR IVIVLSFVRTSLATQSMPPNQVLIGLALFLTFFIMAPTFSEINKEALTPLMDNKISLD EAYTKAEEPIKEFMSKHTRQKDLALFMNYAKMDKPESLKDIPLTTMVPAFAISELKTA FQIGFMIFIPFLIIDMVVASVLMSMGMMMLPPVMISLPFKILLFVLVDGWYLIVKSLL QSF*" gene 1652620..1653285 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" CDS 1653300..1653569 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 15516571, 27855178; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389518.1" /db_xref="EnsemblGenomes-Gn:BSU16360" /db_xref="EnsemblGenomes-Tr:CAB13509" /db_xref="GOA:P35535" /db_xref="InterPro:IPR002191" /db_xref="InterPro:IPR006305" /db_xref="SubtiList:BG10261" /db_xref="UniProtKB/Swiss-Prot:P35535" /translation="MSSEFVISMAEKAVYVTLMISGPLLAIALLVGLIVSIFQATTQI QEQTLAFIPKIVAVLLALIFFGPWMLSTILSFTTELFSNLNRFAG*" gene 1653300..1653569 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" CDS 1653577..1654356 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060055, 15516571, 15849754, 16850406, 28771474; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389519.2" /db_xref="EnsemblGenomes-Gn:BSU16370" /db_xref="EnsemblGenomes-Tr:CAB13510" /db_xref="GOA:P35537" /db_xref="InterPro:IPR002010" /db_xref="InterPro:IPR006303" /db_xref="SubtiList:BG10262" /db_xref="UniProtKB/Swiss-Prot:P35537" /translation="MNSIIDLFPAFLLVFIRISAFFVTIPLFGHRNVPAVHRIGFAFF LAVICFSTIDKPPSLEIDEHYMLLAFKEALVGLCLGLIAYMMIAAVQIAGSFIDFQMG FSIANVIDPQTGAQSPLIGQFIYTMALLFMLSVNAHHLLLDGIYYSFQYISVDQAFPN FGDEKFAYFIAKSFNAMFIIAFQMSAPVVASLFLVDLALGIVARTVPQLNVFVVGLPL KIAVSFIMLIVCMSVIFVVVRNVFSLTIETMRNLLALVGVS*" gene 1653577..1654356 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" CDS 1654356..1655438 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" /function="16.1: Circulate" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 16949608, 17050924, 17067800, 28557186, 28771466; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389520.1" /db_xref="EnsemblGenomes-Gn:BSU16380" /db_xref="EnsemblGenomes-Tr:CAB13511" /db_xref="GOA:P35538" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR006136" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG10543" /db_xref="UniProtKB/Swiss-Prot:P35538" /translation="MKLRVDLQFFAGEKTEKATPKKRKDTRKKGQVAKSSDVNTAVSL LVIFLSLIAIGPYMRDRLLSFIETFYTESLTMKLSESNVHTLFVSLLKDMGMILAPIL LVALVAGVVSNYMQVGFLFSAEVIQPKLEKLDPIKGFKRIYSMRAIVELIKSILKIVV VGFAAFAVLWLHYGEILRLPLLTPEEALSFVSKLTLWMGLSGAGALLILAGLDYLYQR FDYEKNIKMSKQDIKDEYKKSEGDPIIKSKIKQRQREMAMRRMMQEVPKADVIITNPT HYAIALKYDEEKMDAPYIVAKGVDHLALKIRKIAKEHDVMMVENRPLARALYDQVEID QAVPEEFFKVLAEILAYVYKTKQKVY*" gene 1654356..1655438 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" CDS 1655471..1657504 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10234819, 15516571, 20534509, 28771466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10234819, 15516571, 20534509, 28771466; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389521.2" /db_xref="EnsemblGenomes-Gn:BSU16390" /db_xref="EnsemblGenomes-Tr:CAB13512" /db_xref="GOA:P35620" /db_xref="InterPro:IPR001712" /db_xref="InterPro:IPR006301" /db_xref="InterPro:IPR025505" /db_xref="PDB:3MIX" /db_xref="SubtiList:BG10542" /db_xref="UniProtKB/Swiss-Prot:P35620" /translation="MSTRDLSVLISVVLIVAMLVIPFPPWLLSILIIINISLALIVLL TTMNMQEALQFSIFPSLLLLLTLFRLGLNVSTTRSILSHGEGGKVVETFGNFVVGGNV LVGLVVFIILIIIQFIVITKGAERVSEVAARFTLDAMPGKQMSIDADLNAGMITEQEA KHRREKVAREADFYGAMDGASKFVKGDAIAGIIIVMINIIFGIVIGMLQQGMSIQEAA SHFTMLTVGDGIVSQIPALLISTATGIVVTRAASEGNLGHDITGQLFAYPKLLYVAAA TIMLLGIFTPIGILLTGPLAGLLAFGAYTLSKSGKEKEEVDEILEEEAEVDELKSPES VVQLLHIDPIEFEFGYGLIPLADANQGGDLLDRIVMIRRQLALELGLVIPVVRIRDNI ALQPNEYRLKIKGNEVAKGELLLDHYLAMSPTPEDDLIEGIETVEPSFGLPAKWISEA VKDEADMLGYTVVDPASVVSTHITEKIKQHAHELIGRQETKQLIDHLKESYPVLVEEV TPNPLSVGDIQKVLAKLLKEKVSIRNLVTIFETLADYGKLTTDSDLLTEYTRQALAKQ ITAQFAKENEVLKVVTCSGRVEKAIADGVQQTEHGNYLSLEPDISESIVRSVAKEAEQ LSLRQETAILLCSPPVRMYVKQLLERYFPDLPVLSYNELEANVEVQSIGVVDI*" gene 1655471..1657504 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" CDS 1657504..1658604 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1447978, 15317803, 16980502, 17565194, 17699634, 26195616, 27807433; Product type t: transporter" /codon_start=1 /transl_table=11 /product="GTPase involved in the export of flagella and number regulation" /protein_id="NP_389522.1" /db_xref="EnsemblGenomes-Gn:BSU16400" /db_xref="EnsemblGenomes-Tr:CAB13513" /db_xref="GOA:Q01960" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR020006" /db_xref="InterPro:IPR027417" /db_xref="PDB:2PX0" /db_xref="PDB:2PX3" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10544" /db_xref="UniProtKB/Swiss-Prot:Q01960" /translation="MKIKKFTAASMQEAALLIRKELGNEAVILNSKKIKKRKWFGLVN KPAVEVIAVLDQDFLEKKTPQKAAEPKQTLKTPVSSPKIEERTYPPQIPAQQELGDFS AYQSVLPEPLRKAEKLLQETGIKESTKTNTLKKLLRFSVEAGGLTEENVVGKLQEILC DMLPSADKWQEPIHSKYIVLFGSTGAGKTTTLAKLAAISMLEKHKKIAFITTDTYRIA AVEQLKTYAELLQAPLEVCYTKEEFQQAKELFSEYDHVFVDTAGRNFKDPQYIDELKE TIPFESSIQSFLVLSATAKYEDMKHIVKRFSSVPVNQYIFTKIDETTSLGSVFNILAE SKIGVGFMTNGQNVPEDIQTVSPLGFVRMLCR*" gene 1657504..1658604 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" promotor_-10 complement(1658481..1658500) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1658488) /Source="Nicolas_upshifts" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1658514..1658523) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1658595..1659491 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" /function="16.5: Explore" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15361076, 25733861, 26411371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15361076, 25733861, 26411371; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase affecting flagellar basal body localisation and number" /protein_id="NP_389523.1" /db_xref="EnsemblGenomes-Gn:BSU16410" /db_xref="EnsemblGenomes-Tr:CAB13514" /db_xref="GOA:P40742" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR033875" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10254" /db_xref="UniProtKB/Swiss-Prot:P40742" /translation="MQMNRYDQAATLRAKMEKRERVLPMVYSQKAKTLAVISGKGGVG KSNITLNMALALQDKGKKVLLIDLDIGMGNIDILIGNSSSATIIDVLTDRKPLLQSLS VGPKGLRYISGGTGLDVMFQLDQRKWTFFANELSHALSQFDYVLFDMGAGLSKDQLPF ILSAEDILIITTPEPTAIMDAYSAVKHLVLTENKLSMKVAVNRCRDQKEGLDAFARLS RTIHMFLDVQVQFAGSVSDDVIVSKAVVEQVPFFIKSPQAKASRSVRILADALFEREE TRHKEDKQTFIEKLSSFLMRRA*" gene 1658595..1659491 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" CDS 1659493..1660566 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" /EC_number="3.1.1.61" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1738311, 10632876, 12123464, 21515776" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1738311, 10632876, 12123464, 21515776; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCP)-glutamate methylesterase" /protein_id="NP_389524.2" /db_xref="EnsemblGenomes-Gn:BSU16420" /db_xref="EnsemblGenomes-Tr:CAB13515" /db_xref="GOA:Q05522" /db_xref="InterPro:IPR000673" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR008248" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR035909" /db_xref="SubtiList:BG10255" /db_xref="UniProtKB/Swiss-Prot:Q05522" /translation="MIRVLVVDDSAFMRKMISDFLTEEKQIEVIGTARNGEEALKKIE LLKPDVITLDVEMPVMNGTDTLRKIIEIYNLPVIMVSSQTEKGKECTINCLEIGAFDF ITKPSGSISLDLYKIKEQLVERVVAAGLSGKRKRPVSQTVRPEPIVRAVVKPELSKPK PGTGRQIVCIGTSTGGPRALQKVIPKLPKDLNAPVVVVQHMPEGFTASLADRLNHLSD IQVKEAKDGEAALNGCVYIAPGGKNISVIKNSEGLQVVLDNHDTPSRHKPSADYLFRS VGKLTDYEKVAVIMTGMGSDGTAGLKDMLTAGNVKAIAESEESCVVYGMPKAAVKAGL IHEIKHVEDIAASITSCVKKERV*" gene 1659493..1660566 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" CDS 1660572..1662590 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotactic two-component sensor histidine kinase" /protein_id="NP_389525.2" /db_xref="EnsemblGenomes-Gn:BSU16430" /db_xref="EnsemblGenomes-Tr:CAB13516" /db_xref="GOA:P29072" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004105" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008207" /db_xref="InterPro:IPR010808" /db_xref="InterPro:IPR035891" /db_xref="InterPro:IPR036061" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036641" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037006" /db_xref="InterPro:IPR037052" /db_xref="SubtiList:BG10256" /db_xref="UniProtKB/Swiss-Prot:P29072" /translation="MDMNQYLDVFIDESKEHLQTCNEKLLLLEKDPTDLQLVHDIFRA AHTLKGMSATMGYTDLAHLTHLLENVLDAIRNGDMEVTSDWLDILFEALDHLETMVQS IIDGGDGKRDISEVSAKLDVNGAHAESAASAEPAEAQSSASDWEYDEFERTVIQEAEE QGFKRYEIKISLNENCMLKAVRVYMVFEKLNEVGEVAKTIPSAEVLETEDFGTDFQVC FLTHQSAEDIEQLINGVSEIEHVEVIQGAPLTSAEKPEESKQEDSPAAAVPAKQEKQK QPAKNDEQAKHSAGGSKTIRVNIDRLDSLMNLFEELVIDRGRLEQIAKELEHNELTET VERMTRISGDLQSIILNMRMVPVETVFNRFPRMIRQLQKELNKKIELSIIGAETELDR TVIDEIGDPLVHLIRNSIDHGIEAPETRLQKGKPESGKVVLKAYHSGNHVFIEVEDDG AGLNRKKILEKALERGVITEKEAETLEDNQIYELIFAPGFSTADQISDISGRGVGLDV VKNKLESLGGSVSVKSAEGQGSLFSIQLPLTLSIISVLLIKLEEETFAIPISSIIETA VIDRKDILQTHDREVIDFRGHIVPVVYLKEEFKIEDTRKDAEQLHIIVVKKGDKPTAF VVDSFIGQQEVVLKSLGDYLTNVFAISGATILGDGEVALIIDCNALII*" gene 1660572..1662590 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" CDS 1662612..1663082 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12864845, 15451661, 1624415, 8169223, 8169224" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12864845, 15451661, 1624415, 8169223, 8169224; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulation of CheA activity in response to attractants (chemotaxis)" /protein_id="NP_389526.1" /db_xref="EnsemblGenomes-Gn:BSU16440" /db_xref="EnsemblGenomes-Tr:CAB13517" /db_xref="GOA:P39802" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10692" /db_xref="UniProtKB/Swiss-Prot:P39802" /translation="MTAEIKTGEKMIVFMVNGKEYAISVTQVKSIEKWQKPTRVPGVE PYICGVINLRGVVTPVIDLRKRLNLPEYEITDETRIIIIAYRDIEVGWIVDEANDVIT VHESEIESAPEGVQKDTDVSIEQIVKQENRLLNIIDANAVLDKESSQSAVPDQA*" gene 1662612..1663082 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" CDS 1663101..1663730 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal terminating phosphatase of CheR-mediated methylation of methyl-accepting chemotaxis proteins (MCPs)" /protein_id="NP_389527.1" /db_xref="EnsemblGenomes-Gn:BSU16450" /db_xref="EnsemblGenomes-Tr:CAB13518" /db_xref="GOA:P40403" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR028976" /db_xref="SubtiList:BG10749" /db_xref="UniProtKB/Swiss-Prot:P40403" /translation="MSIFNGIKEEQMDILREVGNIGAGHSASAMAQLLNRKIDMEVPF AKLLSFDELVDFFGGADVPVASIFLRMEGDLTGSMFFIMPFFQAEQFIRELIGNPDFD IEDLGEDHMSSSALHELGNILAGSYLTALADLTKLQLYPSVPEVSLDMFGAVISEGLM ELSQVGEHAIVVDTSIFDQSHQQELKAHMFMLPDYDSFEKLFVALGASL*" gene 1663101..1663730 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" CDS 1663727..1664227 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15546616, 16469702, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15546616, 16469702, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sequence specific deamidase required for methylation of methyl-accepting chemotaxis proteins (MCPs) by CheR" /protein_id="NP_389528.1" /db_xref="EnsemblGenomes-Gn:BSU16460" /db_xref="EnsemblGenomes-Tr:CAB13519" /db_xref="GOA:P40404" /db_xref="InterPro:IPR005659" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG10750" /db_xref="UniProtKB/Swiss-Prot:P40404" /translation="MSTTEAVVIKVGIADVKIARFPDTIRTSGLGSCVGLVLYDKEKQ TAGLVHVMLPDSTLSKTAELNRAKYADTAVQTTIDMLIEAGCRKFALKAKLAGGSEMF KFKSTNDLMKIGPRNVLAIKEQLSLFNIPIISEDTGGSSGRTIEFEPKSCMLHIRTVK QGEKTI*" gene 1663727..1664227 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" CDS 1664250..1665014 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" gene 1664250..1665014 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" promotor_-35 1665024..1665030 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1665043..1665546 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" gene 1665043..1665546 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" promotor_-10 1665045..1665056 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1665059 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" promotor_-35 1665542..1665548 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1665563..1665582 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1665565..1665689 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1665565 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1665690..1666430 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" gene 1665690..1666430 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" downshifts 1666412 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" S_feature 1666457..1666531 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1666532..1667413 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" gene 1666532..1667413 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" S_feature 1667414..1667558 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1667559..1668281 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" gene 1667559..1668281 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" CDS 1668283..1668840 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" gene 1668283..1668840 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" downshifts complement(1668787) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" promotor_-35 1668829..1668832 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1668847..1668866 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1668865..1668970 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1668865 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1668971..1669753 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" gene 1668971..1669753 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" CDS 1669757..1670566 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" gene 1669757..1670566 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" promotor_-35 1670547..1670554 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1670569..1670588 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1670570 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1670628..1671779 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" gene 1670628..1671779 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" CDS 1671786..1673054 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" gene 1671786..1673054 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" CDS 1673087..1674781 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" gene 1673087..1674781 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" S_feature 1674782..1674889 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1674890..1679203 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" gene 1674890..1679203 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" S_feature 1679204..1679268 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1679214..1679431 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" gene 1679214..1679431 /gene="surG" /locus_tag="BSU_misc_RNA_71" promotor_-35 1679240..1679246 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1679261..1679272 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1679270..1679337 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1679270 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" promotor_-35 1679320..1679326 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1679339..1679532 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1679339 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" promotor_-10 1679340..1679359 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1679533..1680003 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" gene 1679533..1680003 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" downshifts complement(1679854) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" CDS 1680038..1681153 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" gene 1680038..1681153 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" promotor_no_box complement(1680100..1680200) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1680140) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1681167..1681442 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" gene 1681167..1681442 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" CDS 1681444..1681746 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" gene 1681444..1681746 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" CDS 1681766..1683916 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" gene 1681766..1683916 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" promotor_-35 1683811..1683817 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1683826 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" promotor_-10 1683832..1683850 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1683913..1684191 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" gene 1683913..1684191 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo CDS 1684208..1684561 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" gene 1684208..1684561 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" downshifts 1684552 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" CDS 1684643..1685572 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" gene 1684643..1685572 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" promotor_-35 1685357..1685364 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1685378..1685397 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1685387 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" CDS 1685591..1686541 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" gene 1685591..1686541 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" promotor_-35 1686574..1686580 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1686581..1686697 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1686581 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" promotor_-10 1686595..1686614 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1686698..1686967 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" gene 1686698..1686967 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" downshifts 1686950 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" S_feature 1686995..1687080 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1687061..1687064 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1687080..1687099 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1687082 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" CDS 1687140..1689257 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" gene 1687140..1689257 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" downshifts 1689040 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" downshifts 1689241 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" S_feature 1689286..1689374 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1689375..1690334 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" gene 1689375..1690334 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" promotor_-10 complement(1689443..1689451) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1689446) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1689465..1689472) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1689938..1689943 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1689959..1689977 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1689964 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" CDS 1690374..1691603 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" gene 1690374..1691603 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" downshifts 1691592 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" promotor_-35 1691632..1691637 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1691647 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" promotor_-10 1691653..1691671 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1691681..1691938 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" gene 1691681..1691938 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" S_feature 1691939..1691993 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1691966 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" promotor_-35 1692035..1692044 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1692054..1692123 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1692054 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" promotor_-10 1692058..1692077 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1692124..1693017 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" gene 1692124..1693017 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" CDS 1693020..1693622 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" gene 1693020..1693622 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" misc_feature 1693676..1693695 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1693676..1693747 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1693676 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" CDS 1693748..1694788 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" gene 1693748..1694788 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" S_feature 1694789..1694879 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1694880..1696094 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" gene 1694880..1696094 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" CDS 1696125..1696997 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" gene 1696125..1696997 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" S_feature complement(1696468..1697652) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1697004 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" promotor_-35 1697097..1697100 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1697114 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" promotor_-10 1697116..1697135 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1697175..1698842 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" gene 1697175..1698842 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" promotor_-10 complement(1697639..1697657) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1697656) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" promotor_-35 complement(1697673..1697678) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1698830 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" promotor_-35 1698897..1698903 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1698917..1698928 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1698918 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" CDS 1698958..1699695 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" gene 1698958..1699695 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" CDS 1699692..1699904 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" gene 1699692..1699904 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" misc_feature 1699932..1699951 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1699946 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" CDS 1700035..1702398 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" gene 1700035..1702398 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" S_feature 1702399..1702499 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1702460..1702467 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1702482..1702501 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1702500 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" CDS 1702542..1703267 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" gene 1702542..1703267 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" downshifts 1703254 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" promotor_-35 1703323..1703329 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1703342 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" promotor_-10 1703344..1703355 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1703406..1704614 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" gene 1703406..1704614 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" downshifts 1704572 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" promotor_-35 1704683..1704690 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1704703..1704722 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1704725 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" promotor_-35 1704737..1704740 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1704756..1704768 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1704770 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" CDS 1704794..1706074 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" gene 1704794..1706074 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" CDS 1706071..1707357 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" gene 1706071..1707357 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" downshifts 1707207 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" S_feature 1707358..1707411 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1707412..1708140 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" gene 1707412..1708140 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" promotor_-35 1708156..1708162 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1708174 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" promotor_-10 1708176..1708187 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1708187) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1708198..1708212) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1708221..1708225) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1708221..1708478 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" gene 1708221..1708478 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" downshifts 1708463 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" downshifts complement(1708495) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" promotor_-35 1708536..1708539 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1708554..1708573 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1708554 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" CDS 1708608..1709123 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" gene 1708608..1709123 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo CDS 1709059..1709397 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" gene 1709059..1709397 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo CDS 1709464..1710330 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" gene 1709464..1710330 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" promotor_no_box 1709527..1709627 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1709587 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" downshifts 1710290 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" CDS 1710380..1710961 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" gene 1710380..1710961 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" CDS 1710979..1712229 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" gene 1710979..1712229 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" S_feature 1712230..1712356 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1712336..1712343 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1712358..1712377 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1712358 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" CDS 1712402..1713448 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" gene 1712402..1713448 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" downshifts 1713460 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" S_feature 1713505..1713570 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1713542..1713551 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1713564..1713579 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1713572 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" CDS 1713616..1714791 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " gene 1713616..1714791 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" S_feature 1714792..1714891 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1714865..1714872 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1714886..1714905 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1714893..1715066 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1714893 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" CDS 1715067..1716629 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" gene 1715067..1716629 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" downshifts 1716606 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" CDS 1716698..1717492 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" gene 1716698..1717492 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" promotor_-35 1717247..1717252 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1717268..1717286 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1717288 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" promotor_-35 1717536..1717541 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1717552..1717691 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1717552 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" promotor_-10 1717557..1717575 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1717584) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1717595..1717608) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1717617..1717621) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1717628) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" CDS 1717692..1717952 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" gene 1717692..1717952 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" downshifts 1717904 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" downshifts complement(1717936) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" downshifts 1717948 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" S_feature 1717993..1718167 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1718151..1718158 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1718169 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" promotor_-10 1718173..1718192 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1718218..1719261 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" gene 1718218..1719261 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" CDS 1719274..1720452 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" gene 1719274..1720452 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" downshifts 1720434 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" promotor_-35 1720532..1720535 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1720544 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" promotor_-10 1720550..1720569 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1720600..1722129 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" gene 1720600..1722129 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" CDS 1722131..1722562 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" gene 1722131..1722562 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" downshifts 1722545 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" promotor_-35 1722693..1722698 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1722714..1722732 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1722722..1722823 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1722722 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" CDS 1722824..1723369 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" gene 1722824..1723369 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" downshifts 1723363 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" downshifts complement(1723370) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" promotor_-35 1723427..1723430 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1723445..1723464 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1723449 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" CDS 1723502..1726078 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" gene 1723502..1726078 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" CDS 1726094..1727977 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" gene 1726094..1727977 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" S_feature complement(1727880..1728374) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S611" downshifts 1727892 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" downshifts complement(1727902) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" promotor_-35 1728124..1728131 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1728146..1728165 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1728156..1728289 /Source="Nicolas_S_feature" /locus_tag="new_1780399_1780532" /HighExp="LoTm, T0.30H, T1.30H, M9-stat, T3.0H, BC, T1.0H, B60, B36, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99494800000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S612" upshifts 1728156 /Source="Nicolas_upshifts" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" misc_RNA complement(1728161..1728311) /gene="surX" /locus_tag="BSU_misc_RNA_89" /product="small untranslated RNA of unknown function" /note="Evidence 5: Unknown function; PubMedId : 20525796, 23155385" gene complement(1728161..1728311) /gene="surX" /locus_tag="BSU_misc_RNA_89" downshifts 1728246 /Source="Nicolas_upshifts" /id="D925" /incds=0 /nref=19 /ntot=136 /MaxReadThrough="3.45962" /MaxDrop="4.12444" /score="29.4045648" /energy="-15.3" /TU="U1365" /idTUdmin="U1364" /TUdmin=354 /isTUend="FALSE" CDS complement(1728375..1728830) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="YP_054578.1" /db_xref="EnsemblGenomes-Gn:BSU17060" /db_xref="EnsemblGenomes-Tr:CAE01453" /db_xref="GOA:Q7WY71" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14188" /db_xref="UniProtKB/Swiss-Prot:Q7WY71" /translation="MNQKEQNEHSKDFNLRSKLIGIVSITFIAAIALAVIFGGFFFGM KGLFSILGITYASNQTLALFILACFAVGLIIDPLTKIISIILAKSLSLKKTALFAFIL YFISNLITICFADYFMQSIYIPDVLLVVISAFMAIIELAFDNQPNREAA*" gene complement(1728375..1728830) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" S_feature complement(1728831..1728922) /Source="Nicolas_S_feature" /locus_tag="new_1781074_1781165_c" /HighExp="LBGstat, M9-stat, T1.0H, T1.30H, T2.0H, M0t90, MG 150, LPhT, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S613" promotor_-10 complement(1728910..1728929) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1728922) /Source="Nicolas_upshifts" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" promotor_-35 complement(1728946..1728949) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1728985..1729542) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389588.1" /db_xref="EnsemblGenomes-Gn:BSU17070" /db_xref="EnsemblGenomes-Tr:CAB13579" /db_xref="GOA:O31780" /db_xref="SubtiList:BG13419" /db_xref="UniProtKB/Swiss-Prot:O31780" /translation="MNGIAWMIVFCEIAFWVVIVLGLAVRYVFKRHTLGLLFLALTPV IDLILLAATGVDLYRGASATAAHGIAAVYIGISIAYGKQMIQWADEKFQYYVTKKGTK PLKRFGMDHAKHGAKGWLRHVLAYLIGAGLLAGMIYFINDSSRTEALSGILKLWTVII GIDFLITASYFIWPKKEKASANLRS*" gene complement(1728985..1729542) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" promotor_-35 1729626..1729633 /Source="Nicolas_upshift_promotors" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1729646..1729665 /Source="Nicolas_upshift_promotors" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1729648..1729666) /Source="Nicolas_upshift_promotors" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1729651 /Source="Nicolas_upshifts" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" upshifts complement(1729662) /Source="Nicolas_upshifts" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1729663..1729800 /created_by="AR/SM" /note="N-terminus of previously known orfA is fused to a chromosomal 3`sequence resulting in an artificial C-terminal extension of the truncated protein A, transcription and translation is driven from known promoters and SD of orfA " /NCBI_locus_tag="A8O17_RS20435" /locus_tag="Delta6_BSU_17080-art" /modified_by="User" /transl_table=11 /pseudo /translation="MPKQIDHEKRRKQIAEATWRVILERGMEGASARNIAKEAGLSLE A*" /label="Delta6_BSU_17080-art" gene 1729663..1729800 /created_by="AR/SM" /note="N-terminus of previously known orfA is fused to a chromosomal 3`sequence resulting in an artificial C-terminal extension of the truncated protein A, transcription and translation is driven from known promoters and SD of orfA " /NCBI_locus_tag="A8O17_RS20435" /locus_tag="Delta6_BSU_17080-art" /modified_by="User" /label="Delta6_BSU_17080-art" promotor_-35 complement(1729681..1729686) /Source="Nicolas_upshift_promotors" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1729778,1730841) /created_by="User" /modified_by="User" /label="Delta5" N_region 1729779..1730840 /note="insertion of sequence with unknown origin - insert contains an independent promoter SD and chloramphenicol resistance gene" /created_by="User" /label="Delta5" promotor_-35 1729997..1730002 /created_by="User" /label="Delta5_SigA_-35" promotor_-10 1730020..1730025 /created_by="User" /label="Delta5_SigA_-10" upshifts complement(1730059) /Source="Nicolas_upshifts" /id="U1371" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1370 /SigmaFactorBS="ttcttaaggctgtttctatctatctttccgttcgGAGTTAAC GGcatatgatcaagcTGAATAAAATAAGAAGGCACcatataggcaggcaaagcgtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1730089..1730808 /gene="catA" /NCBI_locus_tag="A8O17_RS08865" /old_locus_tag="A8O17_08865" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_032488880.1" /note="frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology." /pseudo /codon_start=1 /transl_table=11 /product="type A chloramphenicol O-acetyltransferase" /locus_tag="Delta6_NEW_001" /modified_by="User" /translation="MNFNKIDLDNWKRKEIFNHYLNQQTTFSITTEIDISVLYRNIKQ EGYKFYPAFIFLVTRVINSNTAFRTGYNSDGELGYWDKLEPLYTIFDGVSKTFSGIWT PVKNDFKEFYDLYLSDVEKYNGSGKLFPKTPIPENAFSLSIIPWTSFTGFNLNINNNS NYLLPIITAGKFINKGNSIYLPLSLQVHHSVCDGYHAGLFMNSIQELSDRPNDWLL*Y EIMPTVLFTVGFLMSLTCPVS*" /label="Delta6_NEW_001" gene 1730089..1730808 /gene="catA" /locus_tag="Delta6_NEW_001" /old_locus_tag="A8O17_08865" /pseudo /NCBI_locus_tag="A8O17_RS08865" /modified_by="User" /label="Delta6_NEW_001" CDS 1730841..1731323 /note="pseudogene - residual C-terminal sequence due to internal deletion scar" /created_by="AR/SM" /NCBI_locus_tag="A8O17_08870" /locus_tag="Delta6_pseudo_BSU_17220" /modified_by="User" /transl_table=11 /pseudo /translation="EFLSELIDLAKERGLNKPDKQIRAQAQQMMKTQRAYDLESYTVK PLPDPETVKCYYFRNKSRSFFGDLDTYFTLSNEKEPFDQAAYWEEWERQIPHFHLVDV DSSNHFMILTEPKASTALLEFCEKLYSNRGVVNANFLKAFRKKHEAREEKETDELVKR *" /label="Delta6_pseudo_BSU_17220" gene 1730841..1731323 /note="pseudogene - residual C-terminal sequence due to internal deletion scar " /created_by="AR/SM" /NCBI_locus_tag="A8O17_08870" /locus_tag="Delta6_pseudo_BSU_17220" /modified_by="User" /label="Delta6_pseudo_BSU_17220" downshifts 1731312 /Source="Nicolas_upshifts" /id="D927" /incds=0 /nref=65 /ntot=216 /MaxReadThrough="0.92789" /MaxDrop="5.77685" /score="4.87908333" /energy="-14.6" /TU="NA" /idTUdmin="U1370" /TUdmin=1 /isTUend="TRUE" CDS complement(1731368..1732585) /gene="pksS" /locus_tag="BSU_17230" /old_locus_tag="BSU17230" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 17482575, 16707694, 17234808, 17886826, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 of bacillaene metabolism" /protein_id="NP_389605.2" /db_xref="EnsemblGenomes-Gn:BSU17230" /db_xref="EnsemblGenomes-Tr:CAB13607" /db_xref="GOA:O31785" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4YZR" /db_xref="SubtiList:BG12655" /db_xref="UniProtKB/Swiss-Prot:O31785" /translation="MEKLMFHPHGKEFHHNPFSVLGRFREEEPIHRFELKRFGATYPA WLITRYDDCMAFLKDNRITRDVKNVMNQEQIKMLNVSEDIDFVSDHMLAKDTPDHTRL RSLVHQAFTPRTIENLRGSIEQIAEQLLDEMEKENKADIMKSFASPLPFIVISELMGI PKEDRSQFQIWTNAMVDTSEGNRELTNQALREFKDYIAKLIHDRRIKPKDDLISKLVH AEENGSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIAT AVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEILN INRSPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAPDDIQWRKNVF LRGLESLPVSLSK*" gene complement(1731368..1732585) /gene="pksS" /locus_tag="BSU_17230" /old_locus_tag="BSU17230" downshifts complement(1731387) /Source="Nicolas_upshifts" /id="D928" /incds=0 /nref=123 /ntot=225 /MaxReadThrough="0.911470000000001" /MaxDrop="4.23567" /score="16.9796453" /energy="-16.8" /TU="NA" /idTUdmin="U1373" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(1732600..1732700) /Source="Nicolas_upshift_promotors" /id="U1372" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.53046953046953" /psig="0.297702297702298" /xcortree=1727 /SigmaFactorBS="ctaagatagatatatagttttagagacaggattacatttcaa atcattctgttttttgtaaactaattcagcaatttgattcatctatttaccctattag g" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1732640) /Source="Nicolas_upshifts" /id="U1372" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.53046953046953" /psig="0.297702297702298" /xcortree=1727 /SigmaFactorBS="ctaagatagatatatagttttagagacaggattacatttcaa atcattctgttttttgtaaactaattcagcaatttgattcatctatttaccctattag g" /listShort="pksS" /GFF_Attribute="listLong" promotor_-10 complement(1732672..1732691) /Source="Nicolas_upshift_promotors" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1732684) /Source="Nicolas_upshifts" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" S_feature complement(1732686..1732766) /Source="Nicolas_S_feature" /locus_tag="new_1859884_1859964_c" /HighExp="Salt, Etha, T-3.40H, T-0.40H, T-1.40H, LoTm, T-2.40H, S1, SMM, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.122" /TUlongSig="NA" /TUlongPSig="NA" /label="S618" promotor_-35 complement(1732706..1732713) /Source="Nicolas_upshift_promotors" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1732810) /Source="Nicolas_upshifts" /id="D929" /incds=0 /nref=24 /ntot=184 /MaxReadThrough="3.69744" /MaxDrop="5.18486" /score="-0.71313204" /energy="-20.1" /TU="U1374" /idTUdmin="U1375" /TUdmin=28 /isTUend="FALSE" CDS complement(1732816..1733172) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11544224, 15805528, 20817675" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function involved in ethanol resistance" /protein_id="NP_389606.3" /db_xref="EnsemblGenomes-Gn:BSU17240" /db_xref="EnsemblGenomes-Tr:CAB13608" /db_xref="SubtiList:BG13435" /db_xref="UniProtKB/Swiss-Prot:O31786" /translation="MAHTNTQLSQWLESKVGQTLDIRKGELTHDEEISDLDQIVLHLQ KVAIRSTNHPDDYVAKEELVLEGEGTTFTEDGNVPLPQNAYEIPLLGELHIHQENEGL KVVTDRAVYTIDIQHS*" gene complement(1732816..1733172) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" misc_feature complement(1733232..1733245) /Source="Nicolas_upshift_promotors" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1733237) /Source="Nicolas_upshifts" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" CDS complement(1733251..1734075) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20817675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389607.2" /db_xref="EnsemblGenomes-Gn:BSU17250" /db_xref="EnsemblGenomes-Tr:CAB13609" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13413" /db_xref="UniProtKB/Swiss-Prot:O31787" /translation="MPYYICNTCGVQHAQTVDPPNSCLICEDERQYIHPDGQTWTTLE DMREKGNLQNILKKEEEHLYSIKTEPEFAIGQTAHLIQHKGFNVLWDCMTYLDQKTID QINELGGIQAIALSHPHYYSTQVEWAEAFQAPIYIHEDDKEWVTRPSNHIHFWSGETL NMKPGLDLYRLGGHFKGGAVLHWSKGNEGKGCLLTGDIITVAADRNWVSFMYSYPNLI PLPASKVEEIAAKVKPLQFNRLYNAFSKVVKENADESVQRSAVRYIKALNSELFHT*" gene complement(1733251..1734075) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" promotor_-10 complement(1734097..1734116) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1734113) /Source="Nicolas_upshifts" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" promotor_-35 complement(1734128..1734134) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1734186..1735514) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10589719, 16267290, 17884659, 28693413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10589719, 16267290, 17884659, 28693413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline serine protease" /protein_id="NP_389608.1" /db_xref="EnsemblGenomes-Gn:BSU17260" /db_xref="EnsemblGenomes-Tr:CAB13610" /db_xref="GOA:O31788" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG12567" /db_xref="UniProtKB/Swiss-Prot:O31788" /translation="MFGYSMVQMVRANAHKLDWPLRETVLQLYKPFKWTPCFLHKFFE TKLQNRKKMSVIIEFEEGCHETGFQMAGEVLQKEKRSKLKSRFNKINCCSAEVTPSAL HSLLSECSNIRKVYLNREVKALLDTATEASHAKEVVRNGQTLTGKGVTVAVVDTGIYP HPDLEGRIIGFADMVNQKTEPYDDNGHGTHCAGDVASSGASSSGQYRGPAPEANLIGV KVLNKQGSGTLADIIEGVEWCIQYNEDNPDEPIDIMSMSLGGDALRYDHEQEDPLVRA VEEAWSAGIVVCVAAGNSGPDSQTIASPGVSEKVITVGALDDNNTASSDDDTVASFSS RGPTVYGKEKPDILAPGVNIISLRSPNSYIDKLQKSSRVGSQYFTMSGTSMATPICAG IAALILQQNPDLTPDEVKELLKNGTDKWKDEDPNIYGAGAVNAENSVPGQ*" gene complement(1734186..1735514) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" downshifts complement(1734193) /Source="Nicolas_upshifts" /id="D930" /incds=0 /nref=13 /ntot=21 /MaxReadThrough="2.43809" /MaxDrop="5.8915" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1376" /TUdmin=8 /isTUend="TRUE" promotor_-10 complement(1735537..1735556) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1735556) /Source="Nicolas_upshifts" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" promotor_-35 complement(1735570..1735578) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1735671..1735678 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1735686..1735705) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1735694..1735713 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1735697) /Source="Nicolas_upshifts" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" upshifts 1735700 /Source="Nicolas_upshifts" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" promotor_-35 complement(1735718..1735725) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1735739..1735816 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of YmzE" /translation="MNFYLHRSLESQMPISIIYEERRND*" gene 1735739..1735816 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /pseudo downshifts complement(1735741) /Source="Nicolas_upshifts" /id="D931" /incds=0 /nref=4 /ntot=7 /MaxReadThrough="1.51659" /MaxDrop="5.37668" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1377" /TUdmin="-462" /isTUend="FALSE" CDS 1735794..1735970 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of YmzE" /db_xref="PSEUDO:CAX52622.1" /translation="MKKDGTISKRTIIVRQKSKTKIKAFCFSKQQIRTFLLDSILSCD FVRTNKQNLYSAGR*" gene 1735794..1735970 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /pseudo downshifts 1735951 /Source="Nicolas_upshifts" /id="D932" /incds=0 /nref=42 /ntot=207 /MaxReadThrough="4.03151" /MaxDrop="6.55778" /score="-0.929304655" /energy="-5.5" /TU="U1378" /idTUdmin="U1378" /TUdmin="-1496" /isTUend="FALSE" S_feature 1735996..1736184 /Source="Nicolas_S_feature" /locus_tag="new_1863194_1863382" /HighExp="H2O2, M40t90, C90, M40t45, C30, S8, HiOs, G135, T-4.40H, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S619" misc_feature 1736179..1736198 /Source="Nicolas_upshift_promotors" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1736186 /Source="Nicolas_upshifts" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" CDS 1736250..1736957 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /EC_number="3.4.19.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16267290, 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="gamma-polyglutamate hydrolase (phage origin)" /protein_id="NP_389609.1" /db_xref="EnsemblGenomes-Gn:BSU17270" /db_xref="EnsemblGenomes-Tr:CAB13611" /db_xref="GOA:O31789" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13411" /db_xref="UniProtKB/Swiss-Prot:O31789" /translation="MRRFLLNVILVLAIVLFLRYVHYSLEPEPSNQPDTYSNFSSLAE NESPADYDISYNEKKGSKVLIMSPHGGRIEGGVSELVRYFNNEYSTYLFEGLKSHDNQ TLHITSTNFDEPLAKKKIKEHQYVVAFHGYKGENKNTLVGGTDRKRAKMIVRALERRG FSAELASSKSGLAGLNAENINNQGETGLSIQLEISREQREAFFDDFYYKNRKYTKNSE FYAYVSAIKGVLEKEYS*" gene 1736250..1736957 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" promotor_-35 1736968..1736974 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1736988..1737007 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1736992 /Source="Nicolas_upshifts" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" CDS 1737027..1737479 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290, 22904090, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peroxiredoxin-related protein" /protein_id="NP_389610.1" /db_xref="EnsemblGenomes-Gn:BSU17280" /db_xref="EnsemblGenomes-Tr:CAB13612" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019905" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13412" /db_xref="UniProtKB/Swiss-Prot:O31790" /translation="MADHHFYLKANWPGNRNDVGTIESGNLITSISIPKEMDGPGEGT NPDEMLLGAAATCYIITLAAMMERSGLEKEDLQMESEGIVNVTKGVFTYKKIIHRPSV VLKHDASQDDVALAHKLCKKAESSCMISRAIQGNVELQLEASVKLGGE*" gene 1737027..1737479 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" downshifts 1737467 /Source="Nicolas_upshifts" /id="D933" /incds=0 /nref=44 /ntot=182 /MaxReadThrough="1.35366" /MaxDrop="6.07534" /score="17.0193804" /energy="-12.1" /TU="NA" /idTUdmin="U1379" /TUdmin="-2" /isTUend="TRUE" CDS complement(1737493..1737846) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 15849754, 16750162, 16850406, 18024586, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 15849754, 16750162, 16850406, 18024586, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389611.1" /db_xref="EnsemblGenomes-Gn:BSU17290" /db_xref="EnsemblGenomes-Tr:CAB13613" /db_xref="GOA:P0CW82" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12586" /db_xref="UniProtKB/Swiss-Prot:P0CW82" /translation="MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAF TFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLN QSKAHAEDKKQTACE*" gene complement(1737493..1737846) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" downshifts complement(1737534) /Source="Nicolas_upshifts" /id="D934" /incds=0 /nref=2 /ntot=45 /MaxReadThrough="0.84905" /MaxDrop="2.87924" /score="-2.89884673" /energy="-8.7" /TU="NA" /idTUdmin="U1381" /TUdmin="-11" /isTUend="TRUE" CDS complement(1737860..1738177) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 11104814, 17516673, 18024586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 11104814, 17516673, 18024586; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389612.1" /db_xref="EnsemblGenomes-Gn:BSU17300" /db_xref="EnsemblGenomes-Tr:CAB13614" /db_xref="GOA:P0CW80" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12585" /db_xref="UniProtKB/Swiss-Prot:P0CW80" /translation="MLIGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIGYSLA FYMLSLTLNHIPLSLSYATWSGAGTVLTTVIGVKWFKEDLNAKGLIGILLLLSGVVLL NWP*" gene complement(1737860..1738177) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" promotor_-10 complement(1738221..1738240) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1738229) /Source="Nicolas_upshifts" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" promotor_-35 complement(1738255..1738262) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1738314..1738589) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAPFPFYY*" gene complement(1738314..1738589) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" downshifts complement(1738315) /Source="Nicolas_upshifts" /id="D935" /incds=0 /nref=38 /ntot=44 /MaxReadThrough="0.28059" /MaxDrop="8.33353" /score="12.3408391" /energy="-11.5" /TU="NA" /idTUdmin="U1383" /TUdmin=0 /isTUend="TRUE" promotor_-35 1738585..1738590 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1738606..1738624 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1738616..1738635) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1738626 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" upshifts complement(1738629) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" promotor_-35 complement(1738648..1738657) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1738678..1739091 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" gene 1738678..1739091 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" upshifts 1739142 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" misc_feature 1739148..1739167 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1739191..1740135 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" gene 1739191..1740135 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" promotor_-35 1740115..1740123 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1740134..1740152 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1740136 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" CDS 1740175..1740396 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" gene 1740175..1740396 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" downshifts complement(1740186) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" promotor_-10 complement(1740248..1740252) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1740252) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1740267..1740272) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1740396 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" CDS 1740592..1740864 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" gene 1740592..1740864 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" promotor_-35 1740880..1740887 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1740901..1740920 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1740903 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" CDS 1740946..1741176 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" gene 1740946..1741176 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" S_feature 1741177..1741253 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1741210 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" S_feature 1741255..1741362 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1741335..1741342 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1741356..1741375 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1741364 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" CDS 1741419..1741811 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" gene 1741419..1741811 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" CDS 1741771..1743873 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" gene 1741771..1743873 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" CDS 1743891..1744880 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" gene 1743891..1744880 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" downshifts 1744840 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" S_feature complement(1744894..1745553) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1744909) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" CDS 1744930..1745550 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" gene 1744930..1745550 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" downshifts 1745531 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" promotor_-35 1745566..1745570 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1745588..1745955 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1745588 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" promotor_-10 1745592..1745609 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1745598) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" CDS complement(1745614..1746381) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" gene complement(1745614..1746381) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" promotor_-10 complement(1746390..1746409) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1746413) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" promotor_-35 complement(1746422..1746431) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1746535..1746540 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1746556..1746574 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1746556 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1746838..1746843 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1746860..1746878 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1746864..1747004 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1746864 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" CDS 1747005..1747973 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" gene 1747005..1747973 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" downshifts 1747942 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" promotor_-35 1748037..1748045 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1748052 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" promotor_-10 1748056..1748075 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1748106..1749368 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" gene 1748106..1749368 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" CDS 1749386..1750651 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" gene 1749386..1750651 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" promotor_-35 1750699..1750706 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1750721..1750740 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1750733 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" CDS 1750761..1751168 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" gene 1750761..1751168 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" downshifts complement(1750767) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" misc_feature 1751149..1751167 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1751174 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" downshifts complement(1751227) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" CDS 1751227..1752561 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" gene 1751227..1752561 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" downshifts 1752538 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" S_feature 1752583..1752843 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" promotor_-35 1752818..1752825 /Source="Nicolas_upshift_promotors" /id="U1396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig="0.997002997002997" /xcortree=3171 /SigmaFactorBS="agcaataataagatgagtaaggtagatgtttatCATTGACAt cataaccaaatgaATCCATAATTACGTTGAAATctaaatcaattttcaaaaaggagat t" /listShort="ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1752840..1752859 /Source="Nicolas_upshift_promotors" /id="U1396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig="0.997002997002997" /xcortree=3171 /SigmaFactorBS="agcaataataagatgagtaaggtagatgtttatCATTGACAt cataaccaaatgaATCCATAATTACGTTGAAATctaaatcaattttcaaaaaggagat t" /listShort="ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1752845 /Source="Nicolas_upshifts" /id="U1396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig="0.997002997002997" /xcortree=3171 /SigmaFactorBS="agcaataataagatgagtaaggtagatgtttatCATTGACAt cataaccaaatgaATCCATAATTACGTTGAAATctaaatcaattttcaaaaaggagat t" /listShort="ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" CDS 1752889..1753179 /gene="ynxB" /locus_tag="BSU_17470" /old_locus_tag="BSU17470" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective, phage region" /protein_id="NP_389629.1" /db_xref="EnsemblGenomes-Gn:BSU17470" /db_xref="EnsemblGenomes-Tr:CAB13631" /db_xref="GOA:P31844" /db_xref="SubtiList:BG11074" /db_xref="UniProtKB/Swiss-Prot:P31844" /translation="MKKLTIFSGGLGAVFSVLAQLFAVIDDSYTLGNLWFLGALAGII TMLASIQTNNKPVFSILLIASSVIGLLGTGLVYIIPTLFNIIIIYKFSKVSQ*" gene 1752889..1753179 /gene="ynxB" /locus_tag="BSU_17470" /old_locus_tag="BSU17470" S_feature 1753180..1753424 /Source="Nicolas_S_feature" /locus_tag="new_1880378_1880622" /HighExp="Cold, M9-stat, BC, B60, LPhT, T0.30H, LBGstat, LoTm, S4, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.49198399999999998" /TUshortSig="SigA, SigL, SigA" /TUshortPSig="0.997, 0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S626" CDS 1753425..1753769 /gene="ynzF" /locus_tag="BSU_17480" /old_locus_tag="BSU17480" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective phage region" /protein_id="NP_389630.1" /db_xref="EnsemblGenomes-Gn:BSU17480" /db_xref="EnsemblGenomes-Tr:CAB13632" /db_xref="SubtiList:BG13469" /db_xref="UniProtKB/Swiss-Prot:O31799" /translation="MWKALSQLLKKQKNQSPSDEDYIQIPELEVKVLGMLHSINIDLV NVIAQAEKSKEFIGQIEGIWHSIANQFYSLAQGFENEDINKLSADLDHAAATWEAVAN KAKEFVTNSYQG*" gene 1753425..1753769 /gene="ynzF" /locus_tag="BSU_17480" /old_locus_tag="BSU17480" downshifts 1753747 /Source="Nicolas_upshifts" /id="D947" /incds=0 /nref=31 /ntot=125 /MaxReadThrough="3.06401" /MaxDrop="4.27622" /score="-0.54122646" /energy="-8.3" /TU="U1394,U1396" /idTUdmin="U1394" /TUdmin="-440" /isTUend="FALSE" CDS 1753900..1754151 /gene="ynzG" /locus_tag="BSU_17490" /old_locus_tag="BSU17490" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective phage region" /protein_id="NP_389631.1" /db_xref="EnsemblGenomes-Gn:BSU17490" /db_xref="EnsemblGenomes-Tr:CAB13633" /db_xref="SubtiList:BG13470" /db_xref="UniProtKB/Swiss-Prot:O31800" /translation="MLGINVEKSNENLIINWQLSKIEIPIKEINDVFLDPNYGGEEKS AVRIGFPYGSTDRVVIKTARNTYILFTTNPALIMSKIVS*" gene 1753900..1754151 /gene="ynzG" /locus_tag="BSU_17490" /old_locus_tag="BSU17490" promotor_-35 1754177..1754184 /Source="Nicolas_upshift_promotors" /id="U1397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=3172 /SigmaFactorBS="ttaataaacagtttatgtcccttttaaatTTATCTATtaatg ttctgTGTGGTAAAATTTAGTGAGAtgatttaaggaggaggagcatttatggaagaaa t" /listShort="S627, ynaB, ynaC, ynaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1754195..1754214 /Source="Nicolas_upshift_promotors" /id="U1397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=3172 /SigmaFactorBS="ttaataaacagtttatgtcccttttaaatTTATCTATtaatg ttctgTGTGGTAAAATTTAGTGAGAtgatttaaggaggaggagcatttatggaagaaa t" /listShort="S627, ynaB, ynaC, ynaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1754208..1754337 /Source="Nicolas_S_feature" /locus_tag="new_1881406_1881535" /HighExp="LoTm, Etha, LPhT, B60, M9-stat, T3.0H, T3.30H, Salt, T4.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.968584" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.997, 1, 1" /label="S627" upshifts 1754208 /Source="Nicolas_upshifts" /id="U1397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=3172 /SigmaFactorBS="ttaataaacagtttatgtcccttttaaatTTATCTATtaatg ttctgTGTGGTAAAATTTAGTGAGAtgatttaaggaggaggagcatttatggaagaaa t" /listShort="S627, ynaB, ynaC, ynaD" /GFF_Attribute="listLong" CDS 1754338..1754772 /gene="ynaB" /locus_tag="BSU_17500" /old_locus_tag="BSU17500" /function="17.2: Prophage functions" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective phage region" /protein_id="NP_389632.2" /db_xref="EnsemblGenomes-Gn:BSU17500" /db_xref="EnsemblGenomes-Tr:CAB13634" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG12254" /db_xref="UniProtKB/Swiss-Prot:P94480" /translation="MEDATFHFKDPASPQEISDIEQKLGVTFPNDYKEFLLQHNGMEM FDGIEILSLEGIIEYNEVQDFPEGYVLIGYHFDGRYVIDTNKSKNGLGYMLYLDSIDD IEDAINLDSNFEIWFDMLVSLNGTKYWEVNPNLQEYYKLVSE*" gene 1754338..1754772 /gene="ynaB" /locus_tag="BSU_17500" /old_locus_tag="BSU17500" CDS 1754842..1755633 /gene="ynaC" /locus_tag="BSU_17510" /old_locus_tag="BSU17510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389633.1" /db_xref="EnsemblGenomes-Gn:BSU17510" /db_xref="EnsemblGenomes-Tr:CAB13635" /db_xref="SubtiList:BG12255" /db_xref="UniProtKB/Swiss-Prot:P94481" /translation="MTIYEQIKDALKNKINELVSPQEVKKTLQEKYGTNPDSIILSDY CYNRYNKGISFNKHLFEYMNRSSYKYLGENSLYTGLIFRKSKGEDKEVIVGEWVNGVK SLREASVTNNQINDQAEIISKEQLVNLYNEYNQILRYEMNVLNCKPTELRHLIGRIGE FICAIQTNGTLARQTNQHGFDVVSDGRRISVKTTAQSSGFISINKNTFYDFDDFFVVQ YVNDDFKVIFFGSKEEVQKISRIYGSQYEVEISLLKKLNKEYQLN*" gene 1754842..1755633 /gene="ynaC" /locus_tag="BSU_17510" /old_locus_tag="BSU17510" promotor_-10 complement(1754950..1754969) /Source="Nicolas_upshift_promotors" /id="U1398" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.702297702297702" /psig="0.988011988011988" /xcortree=382 /SigmaFactorBS="gaggtgcttattaaaagaaatccccttattaTACcggttata acaataaTCTGATAAAATAATGCTATCcggattagttccgtatttttcttgaagggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1754958) /Source="Nicolas_upshifts" /id="U1398" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.702297702297702" /psig="0.988011988011988" /xcortree=382 /SigmaFactorBS="gaggtgcttattaaaagaaatccccttattaTACcggttata acaataaTCTGATAAAATAATGCTATCcggattagttccgtatttttcttgaagggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1754985..1754987) /Source="Nicolas_upshift_promotors" /id="U1398" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.702297702297702" /psig="0.988011988011988" /xcortree=382 /SigmaFactorBS="gaggtgcttattaaaagaaatccccttattaTACcggttata acaataaTCTGATAAAATAATGCTATCcggattagttccgtatttttcttgaagggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1755629 /Source="Nicolas_upshifts" /id="D948" /incds=0 /nref=10 /ntot=182 /MaxReadThrough="4.47202" /MaxDrop="6.29359" /score="3.60743536" /energy="-14.4" /TU="U1397" /idTUdmin="U1397" /TUdmin="-836" /isTUend="FALSE" downshifts 1755695 /Source="Nicolas_upshifts" /id="D949" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="3.36892" /MaxDrop="4.40772" /score="3.60743536" /energy="-14.4" /TU="U1397" /idTUdmin="U1397" /TUdmin="-770" /isTUend="FALSE" promotor_-35 1755906..1755914 /Source="Nicolas_upshift_promotors" /id="U1399" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.628371628371628" /psig="0.628371628371628" /xcortree=3199 /SigmaFactorBS="gcaatattgttgaataagaatagttttaaAGAGGTTATtgtt gtcttcaTATTGAAATAAAGATTAAGtatattagaggggagttgctttaatgcacata a" /listShort="ynaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1755926..1755944 /Source="Nicolas_upshift_promotors" /id="U1399" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.628371628371628" /psig="0.628371628371628" /xcortree=3199 /SigmaFactorBS="gcaatattgttgaataagaatagttttaaAGAGGTTATtgtt gtcttcaTATTGAAATAAAGATTAAGtatattagaggggagttgctttaatgcacata a" /listShort="ynaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1755937 /Source="Nicolas_upshifts" /id="U1399" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.628371628371628" /psig="0.628371628371628" /xcortree=3199 /SigmaFactorBS="gcaatattgttgaataagaatagttttaaAGAGGTTATtgtt gtcttcaTATTGAAATAAAGATTAAGtatattagaggggagttgctttaatgcacata a" /listShort="ynaD" /GFF_Attribute="listLong" CDS 1755968..1756480 /gene="ynaD" /locus_tag="BSU_17520" /old_locus_tag="BSU17520" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase; putative phage region" /protein_id="NP_389634.1" /db_xref="EnsemblGenomes-Gn:BSU17520" /db_xref="EnsemblGenomes-Tr:CAB13636" /db_xref="GOA:P94482" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12256" /db_xref="UniProtKB/Swiss-Prot:P94482" /translation="MHITTKRLLIREFEFKDWQAVYEYTSDSNVMKYIPEGVFTEEDA KAFVNKNKGDNAEKFPVILRDEDCLIGHIVFYKYFGEHTYEIGWVFNPNYQNKGYASE AAQAILEYGFKEMNLHRIIATCQPENIPSYRVMKKIGMRREGFFKKCIPKGNEWWDEY YYAILEEEWN*" gene 1755968..1756480 /gene="ynaD" /locus_tag="BSU_17520" /old_locus_tag="BSU17520" promotor_-35 1756927..1756933 /Source="Nicolas_upshift_promotors" /id="U1400" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.665334665334665" /psig="0.994005994005994" /xcortree=3213 /SigmaFactorBS="aaagtgaacctgccacagatgttcattatcttttagggggtt ccaaaaagaccgtattccTATCGATcgctcagagtgaaAATGGTATACTAAAGTTACA a" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI, S631" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1756927 /Source="Nicolas_upshifts" /id="U1400" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.665334665334665" /psig="0.994005994005994" /xcortree=3213 /SigmaFactorBS="aaagtgaacctgccacagatgttcattatcttttagggggtt ccaaaaagaccgtattccTATCGATcgctcagagtgaaAATGGTATACTAAAGTTACA a" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI, S631" /GFF_Attribute="listLong" promotor_-35 1756929..1756933 /Source="Nicolas_upshift_promotors" /id="U1401" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=3221 /SigmaFactorBS="aaaaagaccgtattcctaTCGATcgctcagagtgaaAATGGT ATACTAAAGTTACAatcacaggaaggaattacaatttttttagatctacataaaatca t" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1756947..1756966 /Source="Nicolas_upshift_promotors" /id="U1400" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.665334665334665" /psig="0.994005994005994" /xcortree=3213 /SigmaFactorBS="aaagtgaacctgccacagatgttcattatcttttagggggtt ccaaaaagaccgtattccTATCGATcgctcagagtgaaAATGGTATACTAAAGTTACA a" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI, S631" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1756947..1756966 /Source="Nicolas_upshift_promotors" /id="U1401" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=3221 /SigmaFactorBS="aaaaagaccgtattcctaTCGATcgctcagagtgaaAATGGT ATACTAAAGTTACAatcacaggaaggaattacaatttttttagatctacataaaatca t" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1756971..1757039 /Source="Nicolas_S_feature" /locus_tag="new_1884169_1884237" /HighExp="T1.30H, M9-stat, Lbtran, M0t90, T0.30H, T1.0H, T2.30H, Lbstat, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S628" upshifts 1756971 /Source="Nicolas_upshifts" /id="U1401" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=3221 /SigmaFactorBS="aaaaagaccgtattcctaTCGATcgctcagagtgaaAATGGT ATACTAAAGTTACAatcacaggaaggaattacaatttttttagatctacataaaatca t" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI" /GFF_Attribute="listLong" CDS 1757040..1757681 /gene="ynaE" /locus_tag="BSU_17530" /old_locus_tag="BSU17530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389635.1" /db_xref="EnsemblGenomes-Gn:BSU17530" /db_xref="EnsemblGenomes-Tr:CAB13637" /db_xref="InterPro:IPR024976" /db_xref="SubtiList:BG12257" /db_xref="UniProtKB/Swiss-Prot:P94483" /translation="MNLIGYIEERFQNLELIPSIYNQWGTGIHFCLGENIYQLKANEE LNLKMFRIVYEQTSIIFNELFEQNDDIFLVTNMYKHKKKEKCIRKLKVYQPFLKCKNH LNQIMVKTYPYPFEINKAEEYEMQQFSLLCKPRDLRVTELLKAASNEDFPQKPKFGGY SIDYPDVFFVNITKDIIFFIYDDRGCEVIAHDFKRIRPLYEKYHDWVEEYKCM*" gene 1757040..1757681 /gene="ynaE" /locus_tag="BSU_17530" /old_locus_tag="BSU17530" S_feature 1757682..1757769 /Source="Nicolas_S_feature" /locus_tag="new_1884880_1884967" /HighExp="M0t90, Lbtran, Lbstat, T1.30H, S2, T1.0H, T0.30H, MG 150, M9-stat, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S629" CDS 1757770..1758123 /gene="ynaF" /locus_tag="BSU_17540" /old_locus_tag="BSU17540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389636.1" /db_xref="EnsemblGenomes-Gn:BSU17540" /db_xref="EnsemblGenomes-Tr:CAB13638" /db_xref="SubtiList:BG12258" /db_xref="UniProtKB/Swiss-Prot:P94484" /translation="MVLCDDERSAFLLVLDERLVDFDSQGGNHISVYLVTHFELSDQS YKDVLSFNDDLLGMEHNCSYAMDILSVKEELDFDFPFNMLAIKSYVQELIKMLGIDIT LPEMKERDFDKLSQN*" gene 1757770..1758123 /gene="ynaF" /locus_tag="BSU_17540" /old_locus_tag="BSU17540" CDS 1758167..1758442 /gene="ynaG" /locus_tag="BSU_17550" /old_locus_tag="BSU17550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389637.1" /db_xref="EnsemblGenomes-Gn:BSU17550" /db_xref="EnsemblGenomes-Tr:CAB13639" /db_xref="GOA:P94485" /db_xref="SubtiList:BG12259" /db_xref="UniProtKB/Swiss-Prot:P94485" /translation="MNVKKAAAVFSITIPIISAILIINFFTGFMSIPWQGMPVFFPLL LSPIGIILAFVSIKTNKRCAVYGIVLNAIMFPFPFFWFIGGALLFGV*" gene 1758167..1758442 /gene="ynaG" /locus_tag="BSU_17550" /old_locus_tag="BSU17550" downshifts complement(1758543) /Source="Nicolas_upshifts" /id="D950" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="1.74772" /MaxDrop="3.30031" /score="-7.48025946" /energy="-14.4" /TU="NA" /idTUdmin="U1402" /TUdmin=308 /isTUend="FALSE" CDS 1758555..1758719 /gene="ynzI" /locus_tag="BSU_17559" /old_locus_tag="BSU17559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="YP_003097730.1" /db_xref="EnsemblGenomes-Gn:BSU17559" /db_xref="EnsemblGenomes-Tr:CAX52623" /db_xref="GOA:C0H415" /db_xref="UniProtKB/Swiss-Prot:C0H415" /translation="MDRKKDEIQRKYREQMREKKEREKEDGSSHTFEIVVVLAIIILM FFFNSVFKAF*" gene 1758555..1758719 /gene="ynzI" /locus_tag="BSU_17559" /old_locus_tag="BSU17559" S_feature 1758720..1758858 /Source="Nicolas_S_feature" /locus_tag="new_1885918_1886056" /HighExp="M0t90, Lbstat, S1, Lbtran, S2, M40t90, T1.30H, Glu, T1.0H, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S630" CDS 1758859..1759329 /gene="ynaI" /locus_tag="BSU_17560" /old_locus_tag="BSU17560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389638.3" /db_xref="EnsemblGenomes-Gn:BSU17560" /db_xref="EnsemblGenomes-Tr:CAB13640" /db_xref="SubtiList:BG12261" /db_xref="UniProtKB/Swiss-Prot:P94487" /translation="MKLYNEFINIAKTFNKELDIIPLLYGSLGLEKVTGLDFSPEDID LLIPLIFLEEKWEKLKKVMELHGYKMVDLHEHEFKKTNTKIGISYIEDLKPFADVDYN NLEIFEDGGAKYHLLTIDDYLKIYKKSLLDGYRRRKKNHKDQSKINILNKLIRN*" gene 1758859..1759329 /gene="ynaI" /locus_tag="BSU_17560" /old_locus_tag="BSU17560" S_feature 1759330..1760153 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1759493..1759511) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1759511) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1759527..1759532) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1760154..1761545 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" gene 1760154..1761545 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" CDS 1761576..1763177 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" gene 1761576..1763177 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" S_feature complement(1761692..1761997) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1761992..1762011) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1761997) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" promotor_-35 complement(1762025..1762033) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1763175 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" CDS complement(1763314..1764468) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" gene complement(1763314..1764468) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" downshifts complement(1763317) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" S_feature complement(1764367..1764545) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1764513..1764519 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1764528..1764547) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1764529..1764545 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1764539 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1764545) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" promotor_-35 complement(1764562..1764565) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1764572..1764579 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1764594..1764613 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1764605..1764709 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1764606 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" CDS 1764710..1766047 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" gene 1764710..1766047 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" S_feature 1766048..1766122 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1766079 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" CDS 1766198..1767697 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" gene 1766198..1767697 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" S_feature 1767698..1768013 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1767971 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" CDS complement(1768180..1768815) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" gene complement(1768180..1768815) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" promotor_-10 complement(1768852..1768871) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1768861) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" promotor_-35 complement(1768886..1768893) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1769003..1769010 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1769025..1769044 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1769027..1769225 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1769027 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" CDS 1769226..1770641 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" gene 1769226..1770641 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" downshifts 1770631 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" downshifts complement(1770734) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" CDS complement(1770743..1771927) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" gene complement(1770743..1771927) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" S_feature complement(1771928..1772007) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1772000..1772018) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1772011) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" promotor_-35 complement(1772034..1772039) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1772319..1772326 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1772341..1772360 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1772349 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" CDS 1772391..1772852 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" gene 1772391..1772852 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" CDS 1772882..1773316 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" gene 1772882..1773316 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" S_feature complement(1773065..1773370) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1773163 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" S_feature 1773317..1774413 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1773372..1773657) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1773415) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" promotor_-10 complement(1773652..1773671) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1773657) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" promotor_-35 complement(1773683..1773688) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1773919) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" CDS complement(1773919..1774179) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" gene complement(1773919..1774179) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" promotor_-10 complement(1774200..1774219) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1774210) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" promotor_-35 complement(1774232..1774241) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1774414..1774539 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" gene 1774414..1774539 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo S_feature 1774540..1774656 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1774583..1774747 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" gene 1774583..1774747 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" promotor_-35 1774631..1774640 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1774654..1774673 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1774658..1774968 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1774658 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" promotor_-35 1774949..1774956 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1774970..1774989 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1774970 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" CDS 1775021..1775860 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" gene 1775021..1775860 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" promotor_-10 complement(1775043..1775062) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1775064) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1775077..1775080) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1775820 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" downshifts complement(1775966) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" S_feature complement(1775967..1776273) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1775983..1776270) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" gene complement(1775983..1776270) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" downshifts complement(1776010) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" promotor_-35 1776097..1776105 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1776119..1776138 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1776121 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" S_feature 1776132..1776292 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1776264 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" CDS complement(1776313..1777035) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" gene complement(1776313..1777035) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" downshifts complement(1776318) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" misc_feature complement(1777060..1777079) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1777068) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" S_feature complement(1777070..1777194) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1777195..1777551) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" gene complement(1777195..1777551) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" promotor_-10 complement(1777575..1777594) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1777592) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" promotor_-35 complement(1777610..1777614) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1777791) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" CDS complement(1777797..1777997) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" gene complement(1777797..1777997) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" downshifts 1777980 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" promotor_-10 complement(1778019..1778038) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1778031) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" promotor_-35 complement(1778051..1778060) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1778172..1778360) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" gene complement(1778172..1778360) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" downshifts complement(1778188) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" misc_feature complement(1778329..1778336) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1778342) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" promotor_-10 complement(1778389..1778408) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1778407) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" promotor_-35 complement(1778423..1778430) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1778439..1778576 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" gene 1778439..1778576 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" promotor_-35 1778470..1778475 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1778490..1778508 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1778508..1778610 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1778508 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" CDS 1778611..1779009 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" gene 1778611..1779009 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" S_feature 1779010..1779814 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1779074..1779508) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" gene complement(1779074..1779508) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" downshifts complement(1779090) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1779538..1779557) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1779554) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" promotor_-35 complement(1779571..1779578) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1779815..1780003 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" gene 1779815..1780003 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" S_feature 1780004..1780089 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1780048 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" promotor_-35 1780118..1780124 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1780136..1780295 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1780136 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" promotor_-10 1780138..1780149 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1780296..1781858 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" gene 1780296..1781858 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" promotor_-10 complement(1780599..1780618) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1780608) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1780633..1780640) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1781888..1782979 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" gene 1781888..1782979 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" CDS 1782969..1784183 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" gene 1782969..1784183 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" promotor_-35 1784261..1784268 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1784283..1784302 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1784294 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" CDS 1784330..1785136 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" gene 1784330..1785136 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" S_feature complement(1784944..1786042) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1785141..1785758 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" gene 1785141..1785758 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" CDS 1785755..1787395 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" gene 1785755..1787395 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" promotor_-10 complement(1786029..1786048) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1786042) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" promotor_-35 complement(1786062..1786070) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1787035..1787801) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1787432..1787797 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" gene 1787432..1787797 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" downshifts 1787774 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" misc_RNA complement(1787794..1788074) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" gene complement(1787794..1788074) /gene="surA" /locus_tag="BSU_misc_RNA_72" S_feature complement(1787803..1787934) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1787846) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" promotor_-35 1787894..1787903 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1787916..1787925) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1787917..1787936 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1787922 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" S_feature 1787924..1788022 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1787934) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" S_feature complement(1787936..1788066) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1788023..1788781 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" gene 1788023..1788781 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" promotor_-35 1788049 /Source="Nicolas_upshift_promotors" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1788051 /Source="Nicolas_upshift_promotors" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1788056 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" promotor_-10 complement(1788072..1788091) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1788073) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" promotor_-35 complement(1788106..1788113) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1788596..1788807) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1788760 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" S_feature 1788805..1789424 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1788808..1789347) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" gene complement(1788808..1789347) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" promotor_-10 complement(1789348..1789362) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1789354) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" promotor_-35 complement(1789376..1789382) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1789402..1789411 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1789424..1789439 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1789426 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" CDS 1789465..1789899 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" gene 1789465..1789899 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" CDS 1789757..1790104 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" gene 1789757..1790104 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" S_feature 1789900..1790232 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1790191..1790200 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1790212..1790227 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1790234..1790412 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1790234 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" misc_RNA 1790303..1790382 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" gene 1790303..1790382 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" downshifts 1790369 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" CDS complement(1790441..1791058) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" gene complement(1790441..1791058) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" downshifts complement(1790442) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" promotor_-10 complement(1791082..1791101) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1791103) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" promotor_-35 complement(1791115..1791122) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1791138..1791145 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1791157 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" promotor_-10 1791159..1791178 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1791208..1791525 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" gene 1791208..1791525 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" promotor_-10 complement(1791225..1791243) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1791228) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1791257..1791264) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1791544..1792197 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " gene 1791544..1792197 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" promotor_-35 1792200..1792207 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1792221..1792240 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1792234 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" CDS 1792261..1792494 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" gene 1792261..1792494 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" S_feature 1792495..1792630 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1792598..1792605 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1792619..1792638 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1792632 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" CDS 1792663..1794666 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" gene 1792663..1794666 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" misc_feature complement(1792867..1792886) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1792884) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1794656 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" S_feature complement(1794668..1795326) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1794766 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" misc_feature 1794767..1794786 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1794819..1795265 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" gene 1794819..1795265 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" misc_feature 1795289..1795308 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1795297 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" promotor_-10 complement(1795308..1795325) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1795326) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" promotor_-35 complement(1795344..1795348) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1795351..1795569 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" gene 1795351..1795569 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" downshifts 1795581 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" S_feature 1795626..1795925 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1795643..1795816) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" gene complement(1795643..1795816) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" downshifts complement(1795656) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(1795854..1795873) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1795861) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" promotor_-35 complement(1795887..1795894) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1795896..1795904 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1795916..1795935) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1795916..1795934 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1795927..1796035 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1795927 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" upshifts complement(1795928) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" promotor_-35 complement(1795950..1795957) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1796036..1796743 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" gene 1796036..1796743 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" promotor_-35 1796763..1796770 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1796782..1796801 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1796790 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" CDS 1796832..1797194 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" gene 1796832..1797194 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" promotor_-35 1797212..1797215 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1797230..1797249 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1797241 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" CDS 1797273..1797764 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" gene 1797273..1797764 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" downshifts 1797760 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" CDS complement(1797795..1798223) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" gene complement(1797795..1798223) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" downshifts complement(1797812) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1798241..1798260) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1798253) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" S_feature complement(1798255..1798340) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1798274..1798281) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1798311..1798320 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1798330..1798439 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1798330 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" promotor_-10 1798333..1798352 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1798335..1798354) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1798340) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" S_feature complement(1798342..1798425) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1798369..1798372) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1798396 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" CDS complement(1798457..1798849) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" gene complement(1798457..1798849) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" downshifts complement(1798470) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" promotor_-35 1798692..1798697 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1798713..1798731 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1798717 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" promotor_-35 1798827..1798831 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1798841..1798855 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1798856..1798875) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1798858 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1798871) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" promotor_-35 complement(1798889..1798898) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1798930..1799076) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" gene complement(1798930..1799076) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" downshifts complement(1798951) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" CDS complement(1799108..1799254) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" gene complement(1799108..1799254) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" S_feature 1799254..1799387 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1799254 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 1799265..1799267 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1799270..1799281) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1799284) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" promotor_-35 complement(1799296..1799302) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1799377..1799384 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1799389..1799481 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1799389 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" promotor_-10 1799399..1799418 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1799440) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" CDS 1799482..1802211 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" gene 1799482..1802211 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" misc_feature complement(1799502..1799506) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1799506) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 1802212..1802282 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1802283..1802795 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" gene 1802283..1802795 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" downshifts 1802752 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" promotor_-35 1802821..1802827 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1802840 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" promotor_-10 1802842..1802853 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1802876..1803001 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" gene 1802876..1803001 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" downshifts complement(1802894) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" promotor_-35 1803015..1803021 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1803036..1803047 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1803038 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" CDS 1803066..1803212 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" gene 1803066..1803212 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" CDS 1803249..1803500 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" gene 1803249..1803500 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" downshifts 1803478 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" promotor_-35 1803521..1803526 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1803540..1803559 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1803544..1803635 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1803544 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" CDS 1803636..1804001 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" gene 1803636..1804001 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" CDS 1804017..1804316 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" gene 1804017..1804316 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" downshifts 1804292 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" CDS complement(1804347..1804634) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" gene complement(1804347..1804634) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" downshifts complement(1804368) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" downshifts complement(1804434) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" promotor_-10 complement(1804664..1804683) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1804676) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" promotor_-35 complement(1804699..1804706) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1804722..1805303) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" gene complement(1804722..1805303) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" S_feature 1805304..1805434 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1805329..1805348) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1805346) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" promotor_-35 1805419..1805422 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1805436 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" promotor_-10 1805438..1805457 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1805473..1805880 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" gene 1805473..1805880 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" downshifts 1805876 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" promotor_-35 1805942..1805945 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1805960..1805979 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1805964..1806278 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1805964 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" CDS 1806279..1808246 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" gene 1806279..1808246 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" CDS 1808250..1810670 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" gene 1808250..1810670 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" downshifts 1810650 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" S_feature complement(1810678..1810867) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1810717..1810893) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" gene complement(1810717..1810893) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo downshifts complement(1810721) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" CDS complement(1810868..1811278) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" gene complement(1810868..1811278) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo promotor_-10 complement(1811251..1811270) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1811254) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" promotor_-35 complement(1811285..1811292) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1811319..1811338) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1811320) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" promotor_-35 complement(1811353..1811360) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1811367..1811386) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1811378) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" promotor_-35 complement(1811400..1811409) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1811626..1811631 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1811644..1811663 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1811649 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" S_feature 1811662..1811726 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1811727..1813124 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" gene 1811727..1813124 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" downshifts 1813113 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" downshifts 1813158 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" S_feature complement(1813214..1813960) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1813337..1813344 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1813356 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" promotor_-10 1813357..1813376 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1813427..1814926 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" gene 1813427..1814926 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" promotor_-10 complement(1813959..1813978) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1813982) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" promotor_-35 complement(1813992..1814001) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1814874 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" CDS 1814994..1815257 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" gene 1814994..1815257 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" downshifts complement(1815516) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" CDS complement(1815516..1816784) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" gene complement(1815516..1816784) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" S_feature complement(1816785..1816914) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1816915..1818456) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" gene complement(1816915..1818456) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" S_feature complement(1818457..1818778) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1818768..1818787) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1818779) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" promotor_-35 complement(1818802..1818805) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1819005..1819012 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1819025..1819044 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1819032 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1819051..1819497 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" gene 1819051..1819497 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" CDS 1819504..1820397 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" gene 1819504..1820397 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" misc_feature 1820014..1820033 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1820022 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" CDS 1820470..1821066 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" gene 1820470..1821066 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" downshifts 1821056 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" CDS complement(1821115..1822314) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" gene complement(1821115..1822314) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" S_feature complement(1822315..1822386) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1822374..1822385) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1822386) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" promotor_-35 complement(1822400..1822406) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1822484..1824019) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" gene complement(1822484..1824019) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" downshifts complement(1822496) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" CDS complement(1824030..1824812) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" gene complement(1824030..1824812) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" CDS complement(1824833..1825732) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" gene complement(1824833..1825732) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" CDS complement(1825747..1825968) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" gene complement(1825747..1825968) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" CDS complement(1825983..1827317) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" gene complement(1825983..1827317) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" CDS complement(1827327..1828976) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" gene complement(1827327..1828976) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" promotor_no_box 1827376..1827476 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1827436 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(1829020..1830162) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" gene complement(1829020..1830162) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" promotor_-10 complement(1830181..1830199) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1830198) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" promotor_-35 complement(1830215..1830220) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1830253..1830558) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " gene complement(1830253..1830558) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" CDS complement(1830548..1830721) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" gene complement(1830548..1830721) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" CDS complement(1830829..1832361) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" gene complement(1830829..1832361) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" downshifts complement(1830840) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" promotor_-10 complement(1832396..1832415) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1832396) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" promotor_-35 complement(1832428..1832437) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1832497..1832889) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" gene complement(1832497..1832889) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" downshifts complement(1832528) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1832917..1832928) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1832924) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" promotor_-35 complement(1832942..1832948) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1833000..1836839) /gene="ppsE" /locus_tag="BSU_18300" /old_locus_tag="BSU18300" /EC_number="2.3.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 12486459, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 12486459, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase E" /protein_id="NP_389712.1" /db_xref="EnsemblGenomes-Gn:BSU18300" /db_xref="EnsemblGenomes-Tr:CAB13713" /db_xref="GOA:O31827" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11962" /db_xref="UniProtKB/Swiss-Prot:O31827" /translation="MKKGADTMNTIKKIKNIYPLSHMQEGMLFHSFLRKEEGAYVEQS LFTIKGSLSYDWFQRSIQAIIDRHDIFRTVFLPHVPHLSGPRQVVMTEREFHLNSEDI SHLPTNDQNEYIERFKEKDKQKGFDLQKDMLMRISLFKTAKDEHVCIWSHHHILMDGW CLGIVMQEFMQIYQSIHAGKPLSLDPVRPYSTYISWLTNRDKEKAAAYWDTYLKNYSA PSPLPRVSDKETKESYHREDLIFSLNKPLTDKLKETAKQHGVTLATLIQAVWGVMLQQ YNRTDDVVFGAVVSGRPSEIPGVEQMIGLFINTIPIRIKTHQDETFHELLIRCQKEML EAEPFTCQPLFDIQANTALKQELIDHIIVFENYPLQQKIADSADQTDSPLQIDQVQVS EQSGYNFNLVVAPGEELVIKFSYNAFVYDAAWISCIKRQFTQALSTAAQHPHMPIADF SFLDATEKEQIVTQFNNTKTEYPKNHTIIDLFREQAEKTPDHTALVYGNMSISYKELD KRSNALARELIQKGFRKNETAGILAAHSPEFMISVLAVLKAGGAYLPLDAELPPERVS FMLEETQAKMLIVQKGLEQNAAFSGTCIISDAQGLMEENDIPINISSSPDDLAYIMYT SGSTGRPKGVMITNRNVVSLVRNSNYTSASGDDRFIMTGSISFDAVTFEMFGALLNGA SLHIIDKSTMLTPDRFGAYLLENDITVLFLTTALFNQLAQVRADMFRGLHTLYVGGEA LSPALMNAVRHACPDLALHNIYGPTENTTFSTFFEMKRDYAGPIPIGKPISNSTAYIL DTKGRLLPIGVPGELCVGGDGVAKGYLNRVDLTNAVFSPHPFLPGERIYRTGDLARWL PDGNLEYISRIDRQMKIRGKRIEPAEIEARLLEMEGVQEAAVTLREKDGEAQLYTHYV GDHKKTDTDFRADLARVLPDYMIPQHWVRVERMPLTGNGKIDRSALPIPENKPAKRQN IILPRNLVEEELANIWKQVLGVNTISIDDDFFAIGGHSLRALQVIHTLKHQQNIDIPI DFLFEHPTIAQLAEKLYSKQLTAANEQHVIKLNQHGAQNLFCFPPISGFGIYFKDLAL LLNEKAAVYGFHFIEQDTRIEQYVNCMTDIQPEGPYVLLGYSAGGNLAFEVAQAMERK GLEVSDFIIVDAYLKEQPLPIDTGNDESAAYLPEAVREKVMKKKRNYQEYWAQLLNEG HIKASIHFIEAGIHPETSGHTGLTKWEGACGNYSEYTGFGAHKDMLEGTYAEKNADII LDILEKITSNQVILHKR*" gene complement(1833000..1836839) /gene="ppsE" /locus_tag="BSU_18300" /old_locus_tag="BSU18300" downshifts complement(1833012) /Source="Nicolas_upshifts" /id="D1001" /incds=0 /nref=51 /ntot=190 /MaxReadThrough="0.85603" /MaxDrop="4.50208" /score="20.3407616" /energy="-16.7" /TU="NA" /idTUdmin="U1479" /TUdmin="-484" /isTUend="FALSE" CDS complement(1836847..1847658) /gene="ppsD" /locus_tag="BSU_18310" /old_locus_tag="BSU18310" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase D involved in synthesis of plipastatin" /protein_id="NP_389713.2" /db_xref="EnsemblGenomes-Gn:BSU18310" /db_xref="EnsemblGenomes-Tr:CAB13714" /db_xref="GOA:P94459" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11961" /db_xref="UniProtKB/Swiss-Prot:P94459" /translation="MTKANSIQDIYPLSYMQEGMLFHSLLQKDSQAYVEQASFTIEGK VNPQFFQNSINALVERHDIFRTIFISQNVSSPQQVVLRERNVIVLEEDITHLNEAEQS QFIEQWKEKDRDRGFHLQKDVLMRIALIQTGESQYSCIWTFHHIMMDGWCLSIVLKEF LHIYASYVNASPITLEPVQPYGKYIKWLMEQDKEQAVSYWDHYLSGHEQQTVLPKQKK TKGKSRQEHVTFSFSKEESSRLSELAAREEVTLSTIFHTIWGILLQKYNNNDDAVFGS VISGRPAEIEGIEHMVGLFINTMPVRVQGAKTPFLQLIKDMQKDRLAAEAYSYHPLYE IQSRSAVKQGLIDHILVFENYPVQQEIQMLNKQEHASDLFQIHNFTVADETNYSFYLM VAPGEEIHIKMNYDAEQHDRSFVLSVKEHLLNAVSQILNNPNLPPEEIDITTDTEKRQ LIGEITDQTPVYETIHAMFEKQAEKTPDAHAVIDQACSLTYRELNKAANRLARHLRMK GVVRQEPVAIMMERSAAFITGVLGILKAGGAIVPVDPHYPADRIRYILHDCGCSHVVS QAHLPSSLEDNYIITHPEDIESKVDGSNIKSVNNADDLLYMIYTSGTTGKPKGVQFEH RNMANLLKFEYTHSGIDFEADVLQFATPSFDVCYQEIFSALLKGGTLHIVPEAIKRDV PQLFAFINKHQTNIVFLPTAFIKMIFSERELANSFPDGVKHLIAAGEQLMISDLFQDV LRKRGIHLHNHYGPSETHVVSTYTIHPGDPIPELPPIGKPIGCTDLYILNHQKQLQPC GVPGELYISGASVARGYVNHDKLTSDKFSSDPFKPDVIMYRTGDLARRLEDGNIEYIG RADNQVKIRGYRIEPQEIEVTLMNHPDISEAAILIWQDQNGEHELCAYYCSVQKLNTI DLRSYMASELPEYMIPAKWIWVDSIPLTPNGKVDRAALPEPDASISGNPYTAPRNLLE AKLSQLFEDVLKNGHIGIQDNFFDNGGHSLKATVLMSRIAKEFHVQVSLKDIFAHPTV EGLALIIREAEQNLYAAIEPAEKRDTYPVSSAQKRIYVLQQLDEGVAYNMPAVLELEG ALDVAKLSAVCKELISRHEPLRTSFVSGADDEPVQRIHTEVPFTLSKETTIEGFVRPF DLSQAPLFRAGLIEVSNEKHVLLVDMHHIISDGVSVQLLIREFTDLYANRQLKPLRIQ YKDYAVWQQKFKKGDSYQKQETYWQQQFSGDLPILELPTDKRRPAERQFIGGKVTFQL DKEITARIKRLAHKNRSTLYMTLLALYSAFLSRLSGQDDIVIGSPIAGRPHADLEAVL GMFVNTLALRTRPAGNKTFEEFLKEVRQTALEAYEHQDYPFEELVDKLGVQREMSRNP LFDTTLVLQNMEQQKLKMNDVQLQWNDLEHPISKFDISLYVTEHDSELFCQFEYSTAL FEKETIQRWASLFTTLVEHTAASPETELDNIPILTKEEERDFIESCHLFEETGYSMNQ TLHYALEQQAEKTPDQAAVIFEDGVMTYKELNEQANRIAWELIGRGVKPETTVAIIGK RSPEMLLGIYGILKAGGAYLPIDPDYPEERISFLLEDSGTNILLLQSAGLHVPEFTGE IVYLNQTNSGLAHRLSNPNVDVLPQSLAYVIYTSGSTGMPKGVEIEHRSAVNFLNSLQ SRYQLKHSDMIMHKTSYSFDASIWELFWWPYAGASVYLLPQGGEKEPEVIAKAIEEQK ITAMHFVPSMLHAFLEHIKYRSVPIKTNRLKRVFSGGEQLGTHLVSRFYELLPNVSIT NSYGPTEATVEAAFFDCPPHEKLERIPIGKPVHHVRLYLLNQNQRMLPVGCIGELYIA GAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGRTDDQVKIR GYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQLERLLPGY MVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQLWEDVLKN GPVGIHDNFFDRGGHSLKATALVSRITKEFDVQVPLKDVFAHPTVEGLATVIREGTDS PYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNPERMDRAFQ ELIKRHESLRTSFEQDEGGDPVQRIHDEVPFTLQTTVLGARTEQEAAAAFIKPFDLSQ APLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIQEFGELYNNRKLPALRIQYKDY AVWQEGFKTGDAYKMQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKVSFTLEPEV ASGLHKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDLEPILGMFV NTLALRTRPEGGKPFVQYLQEVRETALEAFEHQNYPFEELVDKLELTRDMSRNPVFDA MLVVQNNDYEPLHLHDLQMKPAQVSHLVSKFDLTLQASEGDGNIHFLFEYSTALFEKT TIERWASHLTNVLSIIGKNPKVTLNHIDILTQEERHQLLNEFNTGQANQYGVQTISQL FEQQAARTPKASALVSGDKTLTYQELDEWSNGIARALRSRGVKPDTPVGIMMHRSFSM IASILGVWKAGGCYVPIDPEYPKERKRYILSDSGTKLLMTINEADLGVLADFEGEILT IESVEEDDKSPLPQMSSAHHLAYIIYTSGTTGRPKGVMVEHKGIANTLQWRRNAYAFN ETDTILQLFSFSFDGFITSMFTPLLSGAKAVLLHEEEAKDILAIKHQLSRQRITHMII VPVLYRALLDVVQPEDVKTLRVVTLAGEAADRELIARSLAICPHTELANEYGPTENSV ATTVMRHMEKQAYVSIGQPIDGTQVLILNSNHQLQPIGVAGELCIAGTGLARGYVNLP ELTERAFTQNPFKPEARMYRTGDAARWMADGTLEYLGRIDDQVKIRGYRVETKEIESV IRCIKGVKDAAVVAHVTASGQTELSAYVVTKPGLSTNAVRSELQNKLPVFMHPAFIEK LDSLPLSPNGKLDRGALPKPVYNHEGERPFLPPSSKMEQILADIWKEVLGAEKIGTAD SFFELGGDSIKALQVSARLHRIGKQMAVKDLFSHPTIQELAAYIRDSDTSSSQAAVEG DVQWSPVQKWFLSQDIKEKHHFNQSVMLHRSTSVQEDALRKTLKAITCHHDALRMVFT QNEQGKWDQYNRPLSHSDDALYGLQMIDLSAPDGTDGNRPYEPLIKRHVLDIQQKMDL KNGPLLQAGLFHTIDGDFLFLSAHHLVVDGISWRVLLEDLALGYRQAAGGEDIKLPPK TSSFKAYAKKLSDYAESQQLMKQLKYWREAEEYQTEALPFDQIDGTRAHEGQRSTISF TLNDKETAALLKDANSAYNTDTQDMLLASVILALRHWTNQSAFKLSLEGHGREDVLKG IDVSRTIGWFTAIYPLLIKLNADLPDSEESMVHVLKTTKDTLRRVPDKGFGYGVIKYL TPPGKKDINFTGAPEISFNYLGQFESGRTAEVPEEDAFSFSPLGAGGDISTTWNREQS LDISAIAAEGKLTVNMTYDNARFQRKTIEQLSETCRQFLLQLIEHCQNKSETEKTISD FDDQELTEDALQEIADMLSFH*" gene complement(1836847..1847658) /gene="ppsD" /locus_tag="BSU_18310" /old_locus_tag="BSU18310" promotor_-35 1839867..1839870 /Source="Nicolas_upshift_promotors" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1839887..1839906 /Source="Nicolas_upshift_promotors" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1839888 /Source="Nicolas_upshifts" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(1847683..1855350) /gene="ppsC" /locus_tag="BSU_18320" /old_locus_tag="BSU18320" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non-ribosomal plipastatin synthetase C involved in synthesis of plipastatin" /protein_id="NP_389714.1" /db_xref="EnsemblGenomes-Gn:BSU18320" /db_xref="EnsemblGenomes-Tr:CAB13715" /db_xref="GOA:P39847" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10972" /db_xref="UniProtKB/Swiss-Prot:P39847" /translation="MPQQPEIQDIYPLSFMQEGMLFHSLYDEQSRAYFEQASFTIHGQ LDLERFQKSMDAVFDRYDIFRTAFIYKNVAKPRQVVLKQRHCPIHIEDISHLNERDKE HCTEAFKEQDKSKGFDLQTDVLMRISILKWAPDHYVCIWSHHHILMDGWCLGIVIKDF LHIYQALGKGQLPDLPPVQPYGTYIKWLMQQDREEAAEYWKKRLQHFEKSTPLPKRTD QIPNGTLQQITFAIPEKETAELQKIAAASGATLNTVFQALWGIMLQKVNRSSDAVFGS VISGRPSELKDVENMVGLFINTIPIRAQSDSLSFSDLVRRMQKDMNEAEAYSYFPLYD IQAQSALKQELIDHIIVFENTPTQQEIEELNQAGSFDFSVKDFEMEEVTNYSCSVKVI PGRTLYVRIHFQTSAYQPSMMSEIKDYLLHMVSDVISDPSLPVSKMTLLDEDKTRKIV SQNNRTVSVSPEAPTLHGLFERQAAVTPERLAIRFSGGSLTYAELDMYASRLAAHLAA RGVTNESIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLL TQPGCSAPNFSGETLEVDMTSLECEEVKRHVSASVSDGSLAYVIYTSGSTGQPKGVAV EHRQAVSFLTGMQHQFRLSEDDIVMVKTSFSFDASVWQLFWWALSGASAYLLPPGWEK DSALIVQAIHQENVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAA RFASVLPQVSLIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHL AVQPSGVAGELYIAGAGVARGYLNRPALTEERFLEDPFYLGERMYKTGDVARWLPDGN VEFLGRTDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQR NEVRAQLQRLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVT EMKLSQLWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPT VEGLATVIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLEL EGKLNLERMDRAFKELIKRHESLRTAFEQDAGGDPVQRIHDEVPFTLQTTVLGARTEE EAAAAFIKPFDLSQAPLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIREFGELYN NRKLPALRIQYKDYAVWQEGFKTGDAYKTQGAYWLKQLEGELPVLDLPADHARPPMRS FAGDKVSFTLDQEVTSGLYKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAG RPHKDLEPILGMFVNTLALRTRPEGGKPFVQYLQEVRETAMEAFEHQDYPFEELVDKL ELTRDMSRNPLFDVMFVLQNMDQESLELDELCLKPAANNGHQTSKFDLTLYAQEQPRG LLTFQMEFSTDLYKKKTIEKWLQYFNNMLLSIIKDNKAALGTINILNEDEAHYLIHEL NRTKIDYPRNETISRLFEMQAEQTPNAVAIVSDTQVFTYEDLNSWANQIASVLQIKGV GPDSVVALLTGRTPELIAGMLGILKAGGAYLPIDSNLPVERIAYMLSDSRAALLLQSE KTEKRLLGIECEQIIIEDIQKQGEAKNVESSAGPHSLAYIIYTSGSTGKPKGVMIEQR SVIRLVKNSNYITFTPEDRLLMTSSIGFDVGSFEIFGPLLNGAALHLSDQQTFLDSHQ LKRYIEHQGITTIWLTSSLFNHLTEQNEQTFSQLKHLIIGGEALSPSHVNRIRNVCPE VSIWNGYGPTENTTFSTCLHIQKTYELSIPIGRPVGNSTAFILNQWGVLQPVGAVGEL CVGGDGVARGYLGRPDLTKEKFVPHPFAPGDRLYRTGDLARWLSDGTIEYVGRIDDQV KVRGYRVELGEIETALRQIDGVKEAAVLARTAQTGSKELFGYISVKAGTNAEQVRSLL ARSLPNYMIPAYIIEMETLPLTSNGKLNRKALPEPDVASKQTYIPPRNELEEQLALIW QEVLGIQRIGIEDSFFELGGDSIKALQVSARLGRYGLSLQVSDLFRHPKIKDLSPFIR KSERIIEQGPIQGDVPWTPVQQWFFSQDIEERHHFNQSVMLFHSGRLSENALRPALKK LAEHHDALRMVYRNDDRRWIQINQGIHESQLYSLRISDLSQSESGWETKIKQEVADLQ QSINLQEGPLLHAALFKTLTGDYLFLAIHHLVVDGVSWRILLEDLSAGYQQAAAGQTI QLPPKTDSYQEYARRIQEYAQSSKLIREEAYWRSVEEQQAAELPYEIPHHVNIDFSKR DSLSFSLTEADTAVLLQNVNHAYGTDTQDILLTAASLAICEWTGGSKLRIAMEGHGRE HILPELDISRTVGWFTSMYPALISFENHRDELGTSVKTVKDTLGRIPNKGVGYGMLKY LTHPENKSITFSKTPEISFNYLGQFNDIERQDTFRPSSLGSGKDITHTWKREQIIEMS AMAADKKLHFNLSYPPARFHRNTMEQLINRIEHFLLDIMKHCAGQQKAEKTLSDFSSQ SLTAEDLDSISSLVEEL*" gene complement(1847683..1855350) /gene="ppsC" /locus_tag="BSU_18320" /old_locus_tag="BSU18320" CDS complement(1855367..1863049) /gene="ppsB" /locus_tag="BSU_18330" /old_locus_tag="BSU18330" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase B involved in synthesis of plipastatin" /protein_id="NP_389715.1" /db_xref="EnsemblGenomes-Gn:BSU18330" /db_xref="EnsemblGenomes-Tr:CAB13716" /db_xref="GOA:P39846" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10971" /db_xref="UniProtKB/Swiss-Prot:P39846" /translation="MAQSAQIQDIYPLSHMQEGMLFHSLMDFSSKAYIEQTSFTITGN LCVDSFQKSLNLLVSRYDIFRTIFIKEVPDLTGPQQVVLSNRELTVYREDISRLADQE QQTLIDAFMTKDREKGFDLQKDPLMRLALFDRGDSQYTCVWTHHHIIMDGWCLGIILK EFFSMYDSLKNNSPVQLGSTVPYSRYIEWLGEQDQEETAAYWSEYLKEYGNTASIPRI KRRTADGNYKADQVSFSLAPDMVEKLTEAAQNWGVTLNTLFMSIWGVLLHRYNAADDA VFGSVISGRPSAIDGIESMVGLFINTVPVRIRSAEGITFSSLVKAVQEDILSSEQHGY YPLYEIQNHSPLKQGLIDHIFVFENYPVQLHQALSVESENDEGALKLSDISMSEQTNY DFNIVIVPGESFYIKFSYNADVYEREEMLRIQGHLKQALDCILTNPDVAVSDINIVPP EEQQVIQLFNETERPYVNKTIPQLFEEQAHKTPEAAALKMGNECWTYRQLQVRANQIA HALIEKGVGSGDIVAVMMGRSMEMPAALLGIWKAGGAYMPLDPHFPAERLSFLLKDSQ AAQLLIEEDLISLIPPSYEGNTITIEHTESYQTEAPNMPPGDLAYLIYTSGTTGRPKG VLVDHHGIANTLQWRREEYSMTEQDISLHLFSYVFDGCVTSLFTPLLSGACVLLTTDD EAKDVLALKRKIARYKVSHMIIVPSLYRVLLEVMTADDAKSLRIVTFAGEAVTPDLLE LNQIICPSAELANEYGPTENSVATTILRHLNKKERITIGHPIRNTKVFVLHGNQMQPI GAAGELCISGAGLARGYYKQQELTQKAFSDHPFLEGERLYRTGDAGRFLPDGTIEYIG RFDDQVKIRGYRIELREIETVLRQAPGVKEAAVLARDVSAEEKELVAYIVPEKGNSLP DLYQHLAGTLPSYMIPASIINISQMPLTSSGKLDRFALPEPENNTSVTYMAPRTLIEA DLAHIWEDVLNKQHIGIRDDFFQLGGQSLKAAALVSRIHKKLNVELPLSEVFSYPTVE SMAVKLMSLKEHAFTQIEPADQRDVYPLSFSQKRLYALHQLADDSTGYNMPAVLELRG NLNRQRLRSVLTELVNRHEALRTVFVLDRDEPVQIIYPEMAFDLKELEMESEQMLESA IETFIKPFYLSSGPLFRACVITMGNNRGFLLLDMHHIIADGVSMSTLVQEFTDLYCGK ELPALNLHYKDFAVWQQEKHPKELYKKQEAYWLGQLGGSLPTLELPLDKTRPRLPDFR GGTIEVNIDKDMADELHRLMAETGTTLYMILLAVYSILLSKLSGQEDIVVGSPAAGRP HADLERVIGMFVNTLAMRSKPEGHKTFSSYLHDIRHLALTAYEHQDYPFEELADKLDT NREVNRNPLFDAMLVLQSSEDFRFEVPGLSISSVTPKHDISKFDLTLHAEEHLSGIRC RFEYSTALFEEETITQWASYFIELVKGVTADTEMRISNMQLLPAAERRLLLEKMGQYA AYPRNENIVSLFEKQVAQYPEHIAVVCGHSQLTYRDLNEKAERAAAMLIKQGVRTGDI VGLMLDRSPDMIIGVLSILKAGGAYLPIDPEYPKERISFMLNDSGAKLLLTERGLNKP ADYTGHILYIDECENNSIPADVNIEEIVTDQPAYVIYTSGTTGQPKGVIVEHRNVISL LKHQNLPFEFNHEDVWTLFHSYCFDFSVWEMFGALLNGSTLVVVSKETARDPQAFRLL LKKERVTVLNQTPTAFYGLMLEDQNHTDHLNIRYVIFGGEALQPGLLQSWNEKYPHTD LINMYGITETTVHVTFKKLSAADIAKNKSNIGRPLSTLQAHVMDAHMNLQPTGVPGEL YIGGEGVARGYLNRDELTADRFVSNPYLPGDRLYRTGDLAKRLSNGELEYLGRIDEQV KVRGHRIELGEIQAALLQYPMIKEAAVITRADEQGQTAIYAYMVIKDQQAANISDIRT YLKNALPDFMLPARMIQIDSIPVTVNGKLDQKALPEPEKQAYTADDISPRNEIETVMA EIWEELLNVDELGVSANFFKLGGDSIKALQVCARLKQRGFETTVREMFEHQTLGELSA RVRKDVRAIDQGPVEGEITWTPIQQWFFSQSLESHHFNQSVMIYRAERFDEAALRKVL KSLVTHHDALRIVCRHEDGRQVQINRGIDLSDEELYALELFDVKDSLTEARNTIEEAA SRMQEHIRLETGPLLHAGLFRTENGDHLFLTIHHLVVDAVSWRILFEDFSTAYKQAVS GESIKLPQKTDSYLTYSQRIADYSISRQVQREAAYWDECENRHIQPIPKDNDAASNTF KDTEVIDFELSRHHTELLLTAAHKAYSTEMNDILLTALGLALQKWTGNNQFKISMEGH GRESYLEDIDISRTVGWFTSIYPVWLDMRDSDHKDKEERLGHLIKQTKDMLHRIPHKG AGYGVLKYISKRWGSQKNSPEISFNYLGQFDQDIQSNAFEVSDIKPGNEISPNWERPY ALDISGAVSSGCLNMHIIYNRFQFEEKTIQTFSRHFKQTLENIIEHCTGKENQEWSAS DFTDEDLTLDELSEIMGAVNKL*" gene complement(1855367..1863049) /gene="ppsB" /locus_tag="BSU_18330" /old_locus_tag="BSU18330" downshifts complement(1859038) /Source="Nicolas_upshifts" /id="D1002" /incds=1 /nref=2 /ntot=18 /MaxReadThrough="4.83331" /MaxDrop="4.93461" /score="20.5621533" /energy="-10.2" /TU="U1481,U1483" /idTUdmin="U1481" /TUdmin="-5742" /isTUend="FALSE" upshifts complement(1859082) /Source="Nicolas_upshifts" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" promotor_-10 complement(1859084..1859088) /Source="Nicolas_upshift_promotors" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1859106..1859109) /Source="Nicolas_upshift_promotors" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1859385..1859389 /Source="Nicolas_upshift_promotors" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1859402 /Source="Nicolas_upshifts" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1859405..1859424 /Source="Nicolas_upshift_promotors" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1863074..1870759) /gene="ppsA" /locus_tag="BSU_18340" /old_locus_tag="BSU18340" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 14762003, 16707694, 26284661, 26268540" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 14762003, 16707694, 26284661, 26268540; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="non-ribosomal plipastatin synthetase A involved in synthesis of plipastatin" /protein_id="NP_389716.2" /db_xref="EnsemblGenomes-Gn:BSU18340" /db_xref="EnsemblGenomes-Tr:CAB13717" /db_xref="GOA:P39845" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10970" /db_xref="UniProtKB/Swiss-Prot:P39845" /translation="MSEHTYSLTHAQRRVWFTELLEPDTSICNLTACVKFKGNIELDT LEGALNHSISRNDAIRFQLLEGEELEPRLHLTEYKYYPLRIIDFSNVEMIEIEQWIQD QASIPFKLFNSPLFQFYLLRIDSHEVWLFAKFHHIIMDGISLNVMGNQIIDLYQKMKK KDPLPDQPEPSYLSYIEKESQYLQSPRFAKDRLFWTQTFEHPLEYHSLADQTSLQKQS TSASRDTIILSPDLEQTIRIFCEEHKINIISLFMASFYICISRITSKKDLAIGTYYGN RGSKAEKEMLGMFVSSLPIRITVDPDTDFLSFVRTIGREQLSVMRHQRFPYNLLVNEL RNEQKDLHNLIGISMQYQPLQWHNADDFDYETALYFSGYTANELSVQIQERIDNGTIQ LNFDYQNTLFSLEDIKRIQSHLLTILENALKHPHSFIRELDMTNTREKQKLLYEFNKT EAVSPKAFTLHGLFERQAAFTPERLAIRFSGGSLTYAELDMYASRLAAHLAARGVTNE SIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLLTQPGCS APNFSGETLEVDMTSLASEKAENHEFTPADGGSLAYVIYTSGSTGQPKGVAVEHRQAV SFLTGMQHQFPLSEDDIVMVKTSFSFDASVWQLFWWSLSGASAYLLPPGWEKDSALIV QAIHQENVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAARFASVL PQVSLIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHLAVQPSG VAGELYIAGAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGR TDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQ LERLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQ LWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPTVEGLAT VIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNP ERMERAFKELIKRHESLRTSFEQDAGGDPVQRIHDEVPFTLQTTVLGERTEQEAAAAF IKPFDLSQAPLFRAQIVKISDERHLLLVDMHHIISDGVSVNILIREFGELYNNRNLPA LRIQYKDYAVWREGFKTGDAYKTQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKV SFTLDQEVASGLHKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDL EPILGMFVNTLALRTRPEGGKPFVQYLQEVRETALEAFEHQDYPFEELVDKLELTRDM SRNPVFDAMFILQNVEKQDIDLREIKVRPANFAHHISLFDITLIATEISGSICCEMEF STEVFLKATIERWADHFIEFLHEALSTPETSLAQINILSDKEKQKIVFEFNKTQVEFA QKDIPFHRIFEAKAEENPEHIAVIDNETEISYRLLNERANRLARTLQNRKGPKPTVAV LAKRSIDAIVGVLAVMKAGGVYIPIDAHYPKARIEYILRDSGADILLLQRELKHLISN SPESEMSHIFLDDEGSFEESNCNLNLSPAPEEPVYIIYTSGTTGAPKGVIVTYQNFTH AALAWRQIYELDRKPVRLLQIASFSFDVFSGDLARTLTNGGTLIVCPDETRLEPAEIY KIIKSQRITVMESTPALIIPVMEYVYRNQFKLPDLDILILGSDMVKAQDFKTLTDRFG QSMRIINSYGVTEATIDSSFYETSMGGECTGDNVPIGSPLPNVHMYVLSQTDQIQPIG VAGELCIGGAGVAKGYHHKPDLTQMKFTENPFVSGERLYRTGDRACWLPNGTIRLLGR MDYQVKINGYRIETEEIESVLLQTGLVREAAVAVQHDKNGQAGLAAYIVPSDVNTNAL RAALTKELPAYMIPAYLIPLVNMPLTLNGKLDRNALPAPNNVLSRPYTAPVNDLQKTM AYIWEDVLSMSRVGIHDSFFELGGDSIKALQVAARLAAEGWSMTIRDLFRYSTIQELC GHITPLASQADQGPAEGEAELTPIQRRFFGQVHAFHYHYNQSVMLFSEKGFNANALHL ALRKITEHHDAIRMIFQRDQNGHVIQFNRGINHKDHELFGLYISDWTKASLERAHLDE KLAAEETVIQSKMNVEKGPLLQAGLFKTAEGDHLLIALHHLVIDGVSWRILLEDLAAA YQQALEKKEIQLPPKTDSYLSYADGLTQIAESKQLLSEKTYWQTILDAHTAFLPKDIE NVPDKLQMNSDAAAFVLSGDWTEKLLFETQQAYGTDANELLLTALGMALSEWTGHDQI VISTEGHGREGHVPNIDISRTVGWFTSIYPILLDMGIPEPFEDQLAYRIKTTKDMLRR VPNKGTGYGLLTHIGELRHKEPEVSFNYLGQFSEEKEVETFQLSYYQPRYEIAGERER EYELDINALITDGRLHVKAVYTQVFSKHSIECFMDRFHRHLIETIEHCSQKKAREKTL SDFSNKELTLSALSSIEDLVKDL*" gene complement(1863074..1870759) /gene="ppsA" /locus_tag="BSU_18340" /old_locus_tag="BSU18340" S_feature complement(1870760..1870868) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1870853..1870872) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1870868) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" promotor_-35 complement(1870886..1870893) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1871142..1872617) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" gene complement(1871142..1872617) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" downshifts complement(1871154) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" CDS complement(1872651..1873628) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" gene complement(1872651..1873628) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" promotor_-10 complement(1873657..1873675) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1873669) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" promotor_-35 complement(1873687..1873695) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1873762..1875153) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" gene complement(1873762..1875153) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" downshifts complement(1873776) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" downshifts 1873922 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" promotor_-35 1874943..1874949 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1874963..1874981 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1874974..1875307 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1874974 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" S_feature complement(1875154..1875258) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1875218..1875318) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1875258) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" promotor_-35 1875280..1875285 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1875301..1875319 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1875309 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" promotor_-35 1875367..1875374 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1875387..1875406 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1875390 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" CDS 1875439..1875984 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" gene 1875439..1875984 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" downshifts 1875968 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" tRNA complement(1876078..1876150) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(1876078..1876150) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" downshifts complement(1876176) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" CDS complement(1876203..1876748) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" gene complement(1876203..1876748) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" promotor_-10 complement(1876788..1876807) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1876802) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" promotor_-35 complement(1876821..1876828) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1877064..1877294) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" gene complement(1877064..1877294) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" downshifts complement(1877078) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(1877320..1877339) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1877332) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" promotor_-35 complement(1877351..1877357) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1877386..1877405) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1877396) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1877409..1877416 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1877430..1877449 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1877434 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" CDS 1877479..1879242 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" gene 1877479..1879242 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" downshifts 1879223 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" CDS complement(1879343..1880200) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" gene complement(1879343..1880200) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" promotor_-10 complement(1880246..1880265) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1880266) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" promotor_-35 complement(1880279..1880286) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1880328..1881317 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" gene 1880328..1881317 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" S_feature complement(1880384..1881342) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1881374..1882855) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" gene complement(1881374..1882855) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" downshifts complement(1881387) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" CDS complement(1882872..1887434) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" gene complement(1882872..1887434) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" promotor_no_box 1885895..1885995 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1885955 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(1887435..1887506) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1887486..1887505) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1887503..1887510 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1887506) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" promotor_-35 complement(1887520..1887527) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1887522 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" promotor_-10 1887525..1887544 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1887581..1888483 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" gene 1887581..1888483 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" downshifts 1888463 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" CDS complement(1888535..1889650) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" gene complement(1888535..1889650) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" CDS complement(1889647..1890540) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" gene complement(1889647..1890540) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" promotor_-10 complement(1890545..1890564) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1890553 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" upshifts complement(1890563) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" promotor_-35 complement(1890578..1890584) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1890593..1890611) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1890611) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" promotor_-35 complement(1890627..1890632) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1890688..1891056) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" gene complement(1890688..1891056) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" promotor_-10 complement(1891091..1891109) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1891114) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" S_feature complement(1891116..1891235) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1891121..1891129) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1891227..1891246) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1891235) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" S_feature complement(1891237..1891333) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1891261..1891268) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1891356..1892072) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" gene complement(1891356..1892072) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" downshifts complement(1891378) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" promotor_-10 complement(1892110..1892129) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1892119) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" promotor_-35 complement(1892145..1892148) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1892173..1892179 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1892193..1892211 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1892198 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" CDS 1892223..1892528 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " gene 1892223..1892528 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" downshifts 1892512 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" CDS 1892599..1893369 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" gene 1892599..1893369 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" promotor_-35 1893351..1893358 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1893370 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" promotor_-10 1893373..1893392 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1893413..1893946 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" gene 1893413..1893946 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" S_feature 1893947..1894032 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1893989 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" CDS complement(1894025..1895269) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" gene complement(1894025..1895269) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" S_feature 1894034..1894773 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1894039) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" S_feature complement(1895270..1895362) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1895363..1896826) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" gene complement(1895363..1896826) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" CDS complement(1896844..1897878) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" gene complement(1896844..1897878) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" S_feature complement(1897890..1897961) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1897933) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" misc_RNA complement(1897962..1898053) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene complement(1897962..1898053) /gene="mswF" /locus_tag="BSU_misc_RNA_31" promotor_-10 complement(1898081..1898100) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1898093) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" promotor_-35 complement(1898115..1898122) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1898135..1898142 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1898156..1898175 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1898160 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" CDS 1898202..1900244 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" gene 1898202..1900244 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" promotor_-35 1900252..1900261 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1900274..1900289 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1900277 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" CDS 1900311..1900604 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" gene 1900311..1900604 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" downshifts 1900584 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" S_feature complement(1900629..1900976) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1900660) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" CDS complement(1900977..1901381) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" gene complement(1900977..1901381) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" S_feature complement(1901382..1901477) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1901467..1901482) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1901467..1901586) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" gene complement(1901467..1901586) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" upshifts complement(1901477) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" promotor_-35 complement(1901495..1901504) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1901582..1901588 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1901602..1901613 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1901613..1901821 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1901613 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" CDS 1901656..1901778 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" gene 1901656..1901778 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" CDS 1901822..1902115 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" gene 1901822..1902115 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" S_feature 1902116..1902209 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1902166 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" CDS complement(1902231..1903916) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" gene complement(1902231..1903916) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" downshifts complement(1902243) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" S_feature complement(1903917..1904004) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1903996..1904014) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1904004) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" promotor_-35 complement(1904028..1904035) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1904173..1904182 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1904192 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" promotor_-10 1904195..1904214 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1904241..1905692 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" gene 1904241..1905692 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" downshifts 1905668 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" CDS complement(1905729..1906427) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" gene complement(1905729..1906427) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" downshifts complement(1905744) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" promotor_-10 complement(1906462..1906481) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1906481) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" S_feature complement(1906483..1906696) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1906495..1906502) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1906697..1907374) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" gene complement(1906697..1907374) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" S_feature complement(1907375..1909864) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 1907547..1908584 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" gene 1907547..1908584 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" promotor_-35 1908781..1908787 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1908802..1908813 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1908814 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" CDS 1908841..1909524 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" gene 1908841..1909524 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" CDS complement(1909865..1910170) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " gene complement(1909865..1910170) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" S_feature complement(1910171..1910272) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(1910251..1910270) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1910272) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" promotor_-35 complement(1910285..1910292) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1910300..1910402) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(1910342) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" CDS complement(1910403..1911581) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" gene complement(1910403..1911581) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" promotor_-10 complement(1911607..1911626) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1911626) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" promotor_-35 complement(1911640..1911649) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1911704..1912192) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" gene complement(1911704..1912192) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" downshifts complement(1911729) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" CDS complement(1912217..1912372) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" gene complement(1912217..1912372) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" CDS complement(1912412..1913167) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" gene complement(1912412..1913167) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" promotor_-35 1913420..1913425 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1913441..1913459 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1913456 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" CDS 1913475..1913831 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" gene 1913475..1913831 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" CDS complement(1913790..1914029) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" gene complement(1913790..1914029) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" S_feature 1913832..1914268 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(1914030..1914131) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(1914132..1914629) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" gene complement(1914132..1914629) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" S_feature complement(1914630..1914729) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(1914730..1915641) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" gene complement(1914730..1915641) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" promotor_-10 complement(1915663..1915674) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1915665) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" promotor_-35 complement(1915689..1915695) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1915925..1915932 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1915941 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" promotor_-10 1915947..1915966 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1915988..1916470 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" gene 1915988..1916470 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" CDS 1916480..1916734 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" gene 1916480..1916734 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" S_feature 1916735..1916839 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 1916840..1917634 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" gene 1916840..1917634 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" S_feature 1917635..1918645 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(1917758..1918630) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" gene complement(1917758..1918630) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" CDS 1918731..1919609 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" gene 1918731..1919609 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" S_feature complement(1919722..1919781) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(1919757) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" CDS complement(1919782..1920213) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" gene complement(1919782..1920213) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" promotor_-10 complement(1920233..1920252) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1920241) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" S_feature complement(1920243..1920476) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(1920266..1920272) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1920477..1920495) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1920477..1921109) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" gene complement(1920477..1921109) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" upshifts complement(1920483) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" promotor_-35 complement(1920511..1920516) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1921247..1921254 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1921269..1921288 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1921273 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" CDS 1921335..1922255 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" gene 1921335..1922255 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" promotor_-10 complement(1921766..1921785) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1921781) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1921800..1921807) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1922256..1922913 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(1922752..1923114) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" gene complement(1922752..1923114) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" CDS complement(1923175..1923387) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" gene complement(1923175..1923387) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo promotor_-35 1923426..1923433 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1923448..1923467 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1923451 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" CDS 1923491..1923754 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" gene 1923491..1923754 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" downshifts 1923732 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" CDS complement(1924131..1926731) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" gene complement(1924131..1926731) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" S_feature complement(1926732..1926841) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 1926757..1926764 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1926779..1926798 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1926787..1927414 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 1926787 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" promotor_-10 complement(1926831..1926850) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1926841) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" promotor_-35 complement(1926865..1926871) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1926887..1927346) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(1926929) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" downshifts complement(1927391) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" CDS complement(1927401..1928042) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" gene complement(1927401..1928042) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" S_feature complement(1928043..1928160) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(1928137..1928156) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1928160) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" promotor_-35 complement(1928170..1928172) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1928670..1928909) /gene="yozV" /locus_tag="BSU_18849" /old_locus_tag="BSU18849" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="YP_003097736.1" /db_xref="EnsemblGenomes-Gn:BSU18849" /db_xref="EnsemblGenomes-Tr:CAX52631" /db_xref="GOA:C0H423" /db_xref="InterPro:IPR007829" /db_xref="UniProtKB/Swiss-Prot:C0H423" /translation="MVSKKNKIVAALLAFFFGGLGIHKFYLGRVGQGILYILFCWTGI PSIIAFIEFIIFLCGSEEGFDQKYNFYYFQQQSKA*" gene complement(1928670..1928909) /gene="yozV" /locus_tag="BSU_18849" /old_locus_tag="BSU18849" downshifts complement(1928690) /Source="Nicolas_upshifts" /id="D1030" /incds=0 /nref=31 /ntot=127 /MaxReadThrough="3.22282" /MaxDrop="3.97488" /score="-1.08247697" /energy="-4.5" /TU="U1526" /idTUdmin="U1526" /TUdmin="-529" /isTUend="FALSE" misc_feature complement(1928949..1928968) /Source="Nicolas_upshift_promotors" /id="U1526" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig="0.985014985014985" /xcortree=2315 /SigmaFactorBS="taaaaaatctcaaaagaatttcaaaattttcacgatttctgg cggaaaATGCATTATAATGTGAAAGCattactttaaaaatggtagcaatgaactagga g" /listShort="yozV" /listLong="S710, xynA, S709" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1928956) /Source="Nicolas_upshifts" /id="U1526" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig="0.985014985014985" /xcortree=2315 /SigmaFactorBS="taaaaaatctcaaaagaatttcaaaattttcacgatttctgg cggaaaATGCATTATAATGTGAAAGCattactttaaaaatggtagcaatgaactagga g" /listShort="yozV" /listLong="S710, xynA, S709" promotor_-35 1929015..1929022 /Source="Nicolas_upshift_promotors" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1929037..1929056 /Source="Nicolas_upshift_promotors" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1929044 /Source="Nicolas_upshifts" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" CDS 1929080..1929418 /gene="yobD" /locus_tag="BSU_18850" /old_locus_tag="BSU18850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10376821" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="transcriptional regulator (phage-related, Xre family); putative defective prophage 6" /protein_id="NP_389766.1" /db_xref="EnsemblGenomes-Gn:BSU18850" /db_xref="EnsemblGenomes-Tr:CAB13777" /db_xref="GOA:O34647" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG13497" /db_xref="UniProtKB/Swiss-Prot:O34647" /translation="MYCQRLRQLRKAHKLTMEQLAEKIGIAKSSYGGYEAESKKPPLD KLVILARLYDVSVDYILGLTDDPDPKVERKNLKEFLEKPDIHWDGYKLTPEILDPIRK ILKLVTANNN*" gene 1929080..1929418 /gene="yobD" /locus_tag="BSU_18850" /old_locus_tag="BSU18850" S_feature 1929419..1930015 /Source="Nicolas_S_feature" /locus_tag="new_2056617_2057213" /HighExp="M0t90, Lbstat, Lbtran, MG 150, M40t90, MG 15, SMM, GM 25, Fru, GM-0.1" /AntisenseName="yozH" /AntisenseCor="0.41013265801279702" /AntisenseRegPval="-11.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S711" CDS complement(1929452..1929808) /gene="yozH" /locus_tag="BSU_18860" /old_locus_tag="BSU18860" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; putative defective prophage 6" /protein_id="NP_389767.2" /db_xref="EnsemblGenomes-Gn:BSU18860" /db_xref="EnsemblGenomes-Tr:CAB13778" /db_xref="SubtiList:BG13755" /db_xref="UniProtKB/Swiss-Prot:O31837" /translation="MNDLLFAAGNLHIGLGHDYLKCIALLINVKRFFSLTESYGNISD KLAVVAMKGVQFDQFEEAYKAYKETVAINQNSLVDFLSALITLIKAGEKLQKAGESLA IIMNKLLEMSPENSMK*" gene complement(1929452..1929808) /gene="yozH" /locus_tag="BSU_18860" /old_locus_tag="BSU18860" CDS 1930016..1930381 /gene="yozI" /locus_tag="BSU_18870" /old_locus_tag="BSU18870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative defective prophage 6" /protein_id="NP_389768.1" /db_xref="EnsemblGenomes-Gn:BSU18870" /db_xref="EnsemblGenomes-Tr:CAB13779" /db_xref="SubtiList:BG13756" /db_xref="UniProtKB/Swiss-Prot:O31838" /translation="MPKLYTCLICGYKGLIQNPLNNDGEYQKTFDICPCCDFEYGYSE DHDVSLGFIVTPDYLIDAAIQLYRKQWIENGMKTANPEDIPEELRNGDCLKFEVLLKQ LNSLNLDTENFEIKGFNGY*" gene 1930016..1930381 /gene="yozI" /locus_tag="BSU_18870" /old_locus_tag="BSU18870" S_feature complement(1930390..1931516) /Source="Nicolas_S_feature" /locus_tag="new_2057588_2058714_c" /HighExp="BC, Sw, HiOs, C90, Lbstat, M0t90, UNK1, M9-stat, HiTm, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="SigA" /TUlongPSig="0.994" /label="S712" downshifts complement(1930433) /Source="Nicolas_upshifts" /id="D1031" /incds=0 /nref=3 /ntot=99 /MaxReadThrough="3.80479" /MaxDrop="4.2268" /score="22.3776508" /energy="-7.6" /TU="U1528" /idTUdmin="U1528" /TUdmin="-513" /isTUend="FALSE" CDS 1930603..1931262 /gene="yobE" /locus_tag="BSU_18880" /old_locus_tag="BSU18880" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative SOS response associated phage protein; putative defective prophage 6" /protein_id="NP_389769.1" /db_xref="EnsemblGenomes-Gn:BSU18880" /db_xref="EnsemblGenomes-Tr:CAB13780" /db_xref="GOA:O34915" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13498" /db_xref="UniProtKB/Swiss-Prot:O34915" /translation="MCGKFTLFSEFDDIIEQFNIDQFLPEGEYHPSYNVAPSQNILTI INDGSNNRLGKLRWGLIPPCAKDEKIGYKMINARAETLAEKPSFRKPLGSKRCIIPAD SFYEWKRLDPKTKIPMRIKLKSSNLFAFAGLYEKWNTLEGNLLYTCTIITIKPSELME DIHDRMPVILTDENKKEWLNPKNTDPDYLQSLLLPYDADDMEAYQVSSLVNSPELIES H*" gene 1930603..1931262 /gene="yobE" /locus_tag="BSU_18880" /old_locus_tag="BSU18880" downshifts 1931340 /Source="Nicolas_upshifts" /id="D1032" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="1.22982" /MaxDrop="2.96245" /score="5.95470205" /energy="-19.6" /TU="NA" /idTUdmin="U1527" /TUdmin=990 /isTUend="FALSE" CDS complement(1931517..1932440) /gene="yobF" /locus_tag="BSU_18890" /old_locus_tag="BSU18890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389770.1" /db_xref="EnsemblGenomes-Gn:BSU18890" /db_xref="EnsemblGenomes-Tr:CAB13781" /db_xref="SubtiList:BG13499" /db_xref="UniProtKB/Swiss-Prot:O34780" /translation="MLVYIGNGHYCYSNSTAMFLSSIGENVSPQLVEILTGVGLGAMI EYEKNLYFSMRDPDDGINYALNILGFTAEEHQQASDLDDPFPLLKQQIKQNPVILGPL DMGELTYHPNHKNLNGSDHYVLGYQMDNENIYVQDPAGFPFVPLSLDQFKKAWMAERI PYRKGINKYWSTAKKVVTLDNNEIYERAIDYFKRTYRKFEKVDIGLIGREAICFYADQ LLNAPITADTIRHTTFFLFQLSARRANDYAMYFKDRHSHLSVLKTEQAKVFGICHSMS VNKDWKGISEKLMKLADLEDNFRLELLKVGY*" gene complement(1931517..1932440) /gene="yobF" /locus_tag="BSU_18890" /old_locus_tag="BSU18890" promotor_-10 complement(1932296..1932315) /Source="Nicolas_upshift_promotors" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1932299) /Source="Nicolas_upshifts" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" promotor_-35 complement(1932327..1932334) /Source="Nicolas_upshift_promotors" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1932451..1932470) /Source="Nicolas_upshift_promotors" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" /label="promotor_-10" upshifts complement(1932472) /Source="Nicolas_upshifts" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" promotor_-35 complement(1932485..1932492) /Source="Nicolas_upshift_promotors" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" /label="promotor_-35" CDS complement(1932493..1932666) /gene="yozW" /locus_tag="BSU_18898" /old_locus_tag="BSU18898" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; putative defective prophage 6" /protein_id="YP_003097737.1" /db_xref="EnsemblGenomes-Gn:BSU18898" /db_xref="EnsemblGenomes-Tr:CAX52632" /db_xref="UniProtKB/Swiss-Prot:C0H424" /translation="MTEIKANSTVMIHVLADETLSSIKREYVEVDRKTEIGEKIIIVD KNDPDDEYENGAI*" gene complement(1932493..1932666) /gene="yozW" /locus_tag="BSU_18898" /old_locus_tag="BSU18898" CDS 1932811..1933035 /gene="yozX" /locus_tag="BSU_18899" /old_locus_tag="BSU18899" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="YP_003097738.1" /db_xref="EnsemblGenomes-Gn:BSU18899" /db_xref="EnsemblGenomes-Tr:CAX52633" /db_xref="UniProtKB/Swiss-Prot:C0H425" /translation="MNFLLDLFTNWTFDKVLDYTLAAVIWSVFKSRSKQNKYPGYFEK IRRYRNLHPLLRSLSMRVLLSITIHPYMFS*" gene 1932811..1933035 /gene="yozX" /locus_tag="BSU_18899" /old_locus_tag="BSU18899" CDS complement(1933039..1933494) /gene="yozJ" /locus_tag="BSU_18900" /old_locus_tag="BSU18900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389771.1" /db_xref="EnsemblGenomes-Gn:BSU18900" /db_xref="EnsemblGenomes-Tr:CAB13782" /db_xref="SubtiList:BG13757" /db_xref="UniProtKB/Swiss-Prot:O31839" /translation="MADRYVLIEVNEDGEGRLKDEAVTWIDFRLSIVDFNASEGLNQL MEQISKDVKDELVLVLFNYRVKSSYDSWSGATEYEDFFDVEFFKVIKKNYKKFYQGLV TVELDVGINGFDNIESMPTDSNQNYYRNLIAEWEEFYNEDFIPLSLNKR*" gene complement(1933039..1933494) /gene="yozJ" /locus_tag="BSU_18900" /old_locus_tag="BSU18900" promotor_-35 1933554..1933561 /Source="Nicolas_upshift_promotors" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1933576..1933595 /Source="Nicolas_upshift_promotors" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1933580 /Source="Nicolas_upshifts" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" CDS 1933619..1933879 /gene="yozY" /locus_tag="BSU_18908" /old_locus_tag="BSU18908" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="YP_003097739.1" /db_xref="EnsemblGenomes-Gn:BSU18908" /db_xref="EnsemblGenomes-Tr:CAX52634" /db_xref="UniProtKB/Swiss-Prot:C0H426" /translation="MNLRKILLSSALSLGMLVSAAPVLATSSSSEVIVKSDEYDYDTI YQLSPLPNFKPSIEYNGYTYTLTRYYFDYSIQFYTAIYTKVV*" gene 1933619..1933879 /gene="yozY" /locus_tag="BSU_18908" /old_locus_tag="BSU18908" downshifts 1933826 /Source="Nicolas_upshifts" /id="D1033" /incds=0 /nref=1 /ntot=221 /MaxReadThrough="4.57606" /MaxDrop="3.58254" /score="4.613667" /energy="-8.7" /TU="U1530" /idTUdmin="U1530" /TUdmin="-638" /isTUend="FALSE" promotor_-35 1934294..1934297 /Source="Nicolas_upshift_promotors" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1934311..1934330 /Source="Nicolas_upshift_promotors" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1934328 /Source="Nicolas_upshifts" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1934440 /Source="Nicolas_upshifts" /id="D1034" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="3.18248" /MaxDrop="3.66335" /score="32.4789235" /energy="-13.7" /TU="U1530,U1531" /idTUdmin="U1530" /TUdmin="-24" /isTUend="FALSE" CDS 1934657..1934797 /gene="yozZ" /locus_tag="BSU_18909" /old_locus_tag="BSU18909" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage holin (fragment)" /db_xref="PSEUDO:CAX52635.1" /translation="MTVFGDDLTEKFNALLTFLTALGIIVDPTTQGISDSEQAMDYDS PR*" gene 1934657..1934797 /gene="yozZ" /locus_tag="BSU_18909" /old_locus_tag="BSU18909" /pseudo downshifts 1934794 /Source="Nicolas_upshifts" /id="D1035" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.30104" /MaxDrop="4.04304" /score="32.4789235" /energy="-13.7" /TU="NA" /idTUdmin="U1531" /TUdmin=242 /isTUend="FALSE" promotor_-35 1934879..1934886 /Source="Nicolas_upshift_promotors" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1934898..1934917 /Source="Nicolas_upshift_promotors" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1934899 /Source="Nicolas_upshifts" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" CDS 1934952..1936067 /gene="rapK" /locus_tag="BSU_18910" /old_locus_tag="BSU18910" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:16816200, 25225273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200, 25225273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_389772.1" /db_xref="EnsemblGenomes-Gn:BSU18910" /db_xref="EnsemblGenomes-Tr:CAB13783" /db_xref="GOA:O34930" /db_xref="InterPro:IPR011990" /db_xref="SubtiList:BG12664" /db_xref="UniProtKB/Swiss-Prot:O34930" /translation="MSKIASEVVATTLNDWYIAIKKQKVDESIKYYSEIKKLFDEMEE DQEVLAYYSLLEERHKMLLHSSRGEPLQKHTYFTEDNQNFITKTNDKLEYNFYLFEAM YEAYNKNYDRAINLYGLAEKKLAEIPDEIEAAEFYSKVSYLYTLVKQSIVAQHYIKNA ISIYKRHPDYKCKLATSTMIAAANYADMKRFEEAEQYYLEAIDIAKETKDEFLKAQLF HNLSIVYSDWNKPDKCIESLEKAIGNESWLHSIYYINSLFMMIKELFKIDEKMKAINF YNKAQERLILMENKVYEAKISILYNLYCGELKNNFNNCISNIEFLKQQNELESVDELS YIAAKRFESIGAFEEATSFFNAKIWAEQKMNQVEGIL*" gene 1934952..1936067 /gene="rapK" /locus_tag="BSU_18910" /old_locus_tag="BSU18910" promotor_-35 1935791..1935799 /Source="Nicolas_upshift_promotors" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1935808 /Source="Nicolas_upshifts" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" promotor_-10 1935811..1935829 /Source="Nicolas_upshift_promotors" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1936064..1936186 /gene="phrK" /locus_tag="BSU_18920" /old_locus_tag="BSU18920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11587781, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11587781, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapK" /protein_id="NP_389773.1" /db_xref="EnsemblGenomes-Gn:BSU18920" /db_xref="EnsemblGenomes-Tr:CAB13784" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG12646" /db_xref="UniProtKB/Swiss-Prot:O31840" /translation="MKKLVLCVSILAVILSGVALTQLSTDSPSNIQVAERPVGG*" gene 1936064..1936186 /gene="phrK" /locus_tag="BSU_18920" /old_locus_tag="BSU18920" downshifts 1936180 /Source="Nicolas_upshifts" /id="D1036" /incds=0 /nref=232 /ntot=252 /MaxReadThrough="2.33184" /MaxDrop="6.45227" /score="9.89565332" /energy="-10.4" /TU="NA" /idTUdmin="U1532" /TUdmin=0 /isTUend="TRUE" CDS complement(1936312..1936965) /gene="yobHc" /locus_tag="BSU_18930" /old_locus_tag="BSU18930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative DNA phage repair protein; putative defective prophage 6" /db_xref="EnsemblGenomes-Gn:BSU18930" /db_xref="EnsemblGenomes-Tr:CAB13785" /db_xref="GOA:C0SPA8" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="PSEUDO:CAB13785.2" /db_xref="SubtiList:BG13500" /db_xref="UniProtKB/Swiss-Prot:C0SPA8" /translation="MAKAIQSSMWREFGLMCTVGIGDNMLLSKLALDLESKKTKSGIA RWRYEDVPNRLWKVRPLSKMWGIGGRMERNLNRMGISTVGQLAKFPLELLEKKFGIMG NQLYYHAHGIDLSEIGAPLMQGQISFGKSQILFRDYTKREEIKAVLLEICEEVARRAR TYNKVGRTISLGIGYSKDELGGGFHRSKTIDFPTNITMDIYKCCLMFFNKFYSGKKQ* " gene complement(1936312..1936965) /gene="yobHc" /locus_tag="BSU_18930" /old_locus_tag="BSU18930" /pseudo downshifts complement(1936586) /Source="Nicolas_upshifts" /id="D1037" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="1.36944" /MaxDrop="2.50062" /score="17.2005818" /energy="-10" /TU="NA" /idTUdmin="U1535" /TUdmin=1628 /isTUend="FALSE" CDS complement(1937002..1937349) /gene="yobHm" /locus_tag="BSU_18940" /old_locus_tag="BSU18940" /function="16.9: Replicate" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12137951; Product type h: extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage DNA repair protein fragment; putative defective prophage 6" /db_xref="EnsemblGenomes-Gn:BSU18940" /db_xref="EnsemblGenomes-Tr:CAB13786" /db_xref="GOA:O31841" /db_xref="InterPro:IPR001126" /db_xref="PSEUDO:CAB13786.1" /db_xref="SubtiList:BG13758" /db_xref="UniProtKB/Swiss-Prot:O31841" /translation="MTDYSQFPRENILCVDMKSFYASVSAVAMGLNPLTCYLAVVGNT DRQGSVVLAASPALKKDFGIKTGSRLFEIPEDPRIYIVNPQMKLFIRVSTEITKLFYR FVPEKCVHTYSID*" gene complement(1937002..1937349) /gene="yobHm" /locus_tag="BSU_18940" /old_locus_tag="BSU18940" /pseudo CDS complement(1937342..1937635) /gene="yozL" /locus_tag="BSU_18950" /old_locus_tag="BSU18950" /function="16.6: Maintain" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein of phage origin; putative defective prophage 6" /protein_id="NP_389776.1" /db_xref="EnsemblGenomes-Gn:BSU18950" /db_xref="EnsemblGenomes-Tr:CAB13787" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG13759" /db_xref="UniProtKB/Swiss-Prot:O31842" /translation="MMLEQLIQLKQDLIDGSKVEKPSLDDKQIDEMDILVSEALEFNK ELKFKLFNKGFVENVTGRVHYINFEQQKLHVKDQNDNTVYINMNNIIRVIYND*" gene complement(1937342..1937635) /gene="yozL" /locus_tag="BSU_18950" /old_locus_tag="BSU18950" upshifts 1937786 /Source="Nicolas_upshifts" /id="U1534" /multdbtbs="-" /comp="M1" /sig="SigA" /pcomp="0.340659340659341" /psig="0.65034965034965" /xcortree=472 /SigmaFactorBS="tatagatcagaacaaaagttcgatgtaaatgttggtaataaa atataaaggtcaataatgaTATCCGTAGTATTAATAAAGgagagattcttttcgacga g" /listShort="yozM" /GFF_Attribute="listLong" misc_feature 1937787..1937806 /Source="Nicolas_upshift_promotors" /id="U1534" /multdbtbs="-" /comp="M1" /sig="SigA" /pcomp="0.340659340659341" /psig="0.65034965034965" /xcortree=472 /SigmaFactorBS="tatagatcagaacaaaagttcgatgtaaatgttggtaataaa atataaaggtcaataatgaTATCCGTAGTATTAATAAAGgagagattcttttcgacga g" /listShort="yozM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1937844..1938179 /gene="yozM" /locus_tag="BSU_18960" /old_locus_tag="BSU18960" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative bacteriophage protein; putative defective prophage 6" /protein_id="NP_389777.1" /db_xref="EnsemblGenomes-Gn:BSU18960" /db_xref="EnsemblGenomes-Tr:CAB13788" /db_xref="SubtiList:BG13760" /db_xref="UniProtKB/Swiss-Prot:O31843" /translation="MKKRLIGFLVLVPALIMWGITLIESNKKTPVEVLESAWDEFGLF SFEIGITDPAITIGMDQTKSEAKLREYLKDNLSREAKEKYKIYIFKDDTDKLEKEHQE YLKENNLNK*" gene 1937844..1938179 /gene="yozM" /locus_tag="BSU_18960" /old_locus_tag="BSU18960" promotor_no_box complement(1938218..1938318) /Source="Nicolas_upshift_promotors" /id="U1535" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.68031968031968" /psig="0.040959040959041" /xcortree=286 /SigmaFactorBS="aaagcgttggtgactgcattagagtctaaaaactacatatcc tcttttaaagaagatagagagagattacgtgtgaatactaaaaaaaaataaagaataa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(1938225) /Source="Nicolas_upshifts" /id="D1038" /incds=0 /nref=148 /ntot=238 /MaxReadThrough="2.4012" /MaxDrop="4.9328" /score="17.2005818" /energy="-10" /TU="NA" /idTUdmin="U1535" /TUdmin="-11" /isTUend="TRUE" CDS complement(1938226..1941831) /gene="yobI" /locus_tag="BSU_18970" /old_locus_tag="BSU18970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15128444; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage repair NTPase with transmembrane helices; putative defective prophage 6" /protein_id="NP_389778.1" /db_xref="EnsemblGenomes-Gn:BSU18970" /db_xref="EnsemblGenomes-Tr:CAB13789" /db_xref="GOA:O34784" /db_xref="InterPro:IPR011646" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13501" /db_xref="UniProtKB/Swiss-Prot:O34784" /translation="MGEIKKKFVQWLEKLLIRLKEPNVKEESLFEDLSPSNDVDTDGK YSKALSWGLENKKVKNIALTGPYGSGKSSILNTFQKQYSREYSFLNISLATFNTDTDD MENKLEKSILQQMIYRVHDRTIPFSRFKRIKHIRTKSIIINLIFFFAFIIVGIYLFKP DALKGIYAETLVSRSLGTEDQQQIRLTILLALFFIVYPLLAYKRIYHFVRANLKLNKV TIANTTLEKNTGEENSSIFDKYLDEILYFFEASKYNVVIFEDLDRFNNIGIFERLREL NELINNSEQIDRRVVFIYAIKDDIFGDADTEKLTRDRTKFFDFIIPVIPIINASNSGD ILKKKIKHSPYSDLINTHFLEDVTIYIDDMRVLKNIFNEFVIYQQKLSAIDLDPNKML AMIIYKNIYPVDFSKLQYNKGLVYEIFQKKQLIIEEQIKLINAKIQQLERKLANIEVE SLKSIAELNFIYLSELEISNLNSNYDINIDGEVFRGNTSNKDRFFEKLKNADTIYCYL RNRNGPATIKEIATVFGRKPNYFEREDAIKAIEKNEIQKFKKELLELEREKQEIRAQS LQVLITKMNSKDVFSDKLYEKKLLVYLLRHGYIDEMYNHYITYFYPESLSLSDIKFVF SIKNHESLPYSFELDNIGKIMSKLVGAEFKQIEVLNFHLLNYIMDHSEYRNYYDSIIE RLANGSKESVTFIDGFKERAINKAAFIQSISSKWDDFWSFIELRSNYTQQKKEEYLSD ILTYADIADIIRMNKESVMSFTLSKYLNLLSLVSDEEKIKELLLKLQVKFKSLDHLLN SETIYDFVVQRNLYEINIKTLSVILNDAPNITYAAVKNSDQQAVINYVNDNIDIFVEK VLLTEEIEEPEESFLELLNREDLDKRVKHAMIMKKTFAISDIGELIKELWPIVIRENK MVACWSNVITSYVEYNKKMPDFLIAFLNNPVNRKELSKNNIEAFDDKFDEAILEDISE EIINSRDITDETFEVLIASIQSWIYFPLGNVSEKRAKLLIDNDLLSLTPENFKELKLN FDTLHIQLALRNPDEFIDKQGDFSLDANDIKQLIDSNELSQFNKEIFVQHLNSNCLTD GNNDILKDTIYFINEHNLKITNELLTFLLESPTTLDTRLSLLAGQIKHIDNESITEFL TKIGEPYSEIAEKGRRIKISNNRTNKALVTALESKNYISSFKEDRERLRVNTKKK*" gene complement(1938226..1941831) /gene="yobI" /locus_tag="BSU_18970" /old_locus_tag="BSU18970" upshifts complement(1938258) /Source="Nicolas_upshifts" /id="U1535" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.68031968031968" /psig="0.040959040959041" /xcortree=286 /SigmaFactorBS="aaagcgttggtgactgcattagagtctaaaaactacatatcc tcttttaaagaagatagagagagattacgtgtgaatactaaaaaaaaataaagaataa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(1941832..1941976) /Source="Nicolas_S_feature" /locus_tag="new_2069030_2069174_c" /HighExp="LBGstat, Lbstat, M0t90, T3.0H, T1.30H, T3.30H, MG 150, T2.30H, T4.0H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.936" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S713" misc_feature complement(1941969..1941988) /Source="Nicolas_upshift_promotors" /id="U1536" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=3220 /SigmaFactorBS="tgtgttgtttattgatcatctttttttcagaaacttttaatg ccctttCATGTTACAATTAATAGTGAatttcaactggcgataaaggactatattagat g" /listShort="S713, yobI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1941976) /Source="Nicolas_upshifts" /id="U1536" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=3220 /SigmaFactorBS="tgtgttgtttattgatcatctttttttcagaaacttttaatg ccctttCATGTTACAATTAATAGTGAatttcaactggcgataaaggactatattagat g" /listShort="S713, yobI" /GFF_Attribute="listLong" S_feature complement(1941978..1942063) /Source="Nicolas_S_feature" /locus_tag="new_2069176_2069261_c" /HighExp="LBGstat, C30, Lbstat, M0t90, GM 120, GM 25, GM 150, nit, GM 90, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigWXY" /TUshortPSig="0.936, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S714" CDS complement(1942064..1942363) /gene="yoyA" /locus_tag="BSU_18979" /old_locus_tag="BSU18979" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative fragment of phage protein; putative defective prophage 6" /db_xref="PSEUDO:CAX52636.1" /translation="MATEGYGGNNSAPSRSIGFSEFCETLEKNEVVKPENKKSSLDLN NSLDYWKSRFNPGGNLSALDSQVLDIIKKAYNLGMVNKDNMLLRNEAINAYKNSI*" gene complement(1942064..1942363) /gene="yoyA" /locus_tag="BSU_18979" /old_locus_tag="BSU18979" /pseudo S_feature complement(1942364..1942501) /Source="Nicolas_S_feature" /locus_tag="new_2069562_2069699_c" /HighExp="LBGstat, C30, MG 150, GM 150, M0t90, Lbstat, GM 25, GM 90, GM 120, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigWXY" /TUshortPSig="0.936, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S715" promotor_-10 complement(1942479..1942497) /Source="Nicolas_upshift_promotors" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1942501) /Source="Nicolas_upshifts" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" promotor_-35 complement(1942511..1942517) /Source="Nicolas_upshift_promotors" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(1942534..1942917) /gene="asrE" /locus_tag="BSU_misc_RNA_74" /product="small regulatory antitoxin RNA, toxin-antitoxin type I system (BsrE/AsrE)" /experiment="publication(s) with functional evidences, PMID:18948176, 23059907, 24576839, 26565032, 26940229" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23059907, 24576839, 26565032, 26940229; Product type n: RNA" gene complement(1942534..1942917) /gene="asrE" /locus_tag="BSU_misc_RNA_74" S_feature complement(1942548..1942784) /Source="Nicolas_S_feature" /locus_tag="new_2069746_2069982_c" /HighExp="Salt, Etha, S4, LoTm, dia5, Diami, S5, MG 120, S3, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.518, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S716" promotor_-35 1942581..1942583 /Source="Nicolas_upshift_promotors" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1942591) /Source="Nicolas_upshifts" /id="D1039" /incds=0 /nref=39 /ntot=216 /MaxReadThrough="3.37292" /MaxDrop="5.0558" /score="17.2005818" /energy="-10" /TU="U1541" /idTUdmin="U1539" /TUdmin=1 /isTUend="TRUE" promotor_-10 1942599..1942618 /Source="Nicolas_upshift_promotors" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1942604 /Source="Nicolas_upshifts" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" S_feature 1942626..1942779 /Source="Nicolas_S_feature" /locus_tag="new_2069824_2069977" /HighExp="T1.30H, B60, T2.0H, M9-stat, BT, T0.30H, B36, T1.0H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87861900000000004" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S717" CDS 1942685..1942777 /gene="bsrE" /locus_tag="BSU_18978" /old_locus_tag="BSU18978" /experiment="publication(s) with functional evidences, PMID:26565032, 26940229" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26565032, 26940229; Product type f: factor" /codon_start=1 /transl_table=11 /product="type I toxin (BsrE/AsrE)" /protein_id="YP_009513965.1" /translation="MSTFQALMLMLAIGSFIIALLTYIEKIDLP*" gene 1942685..1942777 /gene="bsrE" /locus_tag="BSU_18978" /old_locus_tag="BSU18978" downshifts 1942736 /Source="Nicolas_upshifts" /id="D1040" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="6.71009" /MaxDrop="3.13767" /score="33.1812693" /energy="-14.4" /TU="U1538" /idTUdmin="U1538" /TUdmin="-66" /isTUend="FALSE" S_feature complement(1942786..1942920) /Source="Nicolas_S_feature" /locus_tag="new_2069984_2070118_c" /HighExp="T-0.40H, T0.0H, T0.30H, Salt, S4, M9-stat, T-1.10H, S7, B60, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.518, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S718" downshifts 1942802 /Source="Nicolas_upshifts" /id="D1041" /incds=0 /nref=135 /ntot=196 /MaxReadThrough="2.41468" /MaxDrop="5.72925" /score="33.1812693" /energy="-14.4" /TU="NA" /idTUdmin="U1538" /TUdmin=0 /isTUend="TRUE" downshifts complement(1942829) /Source="Nicolas_upshifts" /id="D1042" /incds=0 /nref=13 /ntot=114 /MaxReadThrough="6.34283" /MaxDrop="4.1536" /score="3.24083135" /energy="-14.3" /TU="U1539,U1541" /idTUdmin="U1539" /TUdmin="-237" /isTUend="FALSE" upshifts complement(1942920) /Source="Nicolas_upshifts" /id="U1539" /multdbtbs="-" /comp="M3" /sig="SigA" /pcomp="0.44955044955045" /psig="0.518481518481518" /xcortree=755 /SigmaFactorBS="cttgaggtttattgtaatgcatttcacggaaaatgtgttata atcagtttTAcaatacattacagtgcatttctttaatgagaaatgcataaaataaaaa a" /listShort="S718, S716" /GFF_Attribute="listLong" S_feature complement(1942922..1943045) /Source="Nicolas_S_feature" /locus_tag="new_2070120_2070243_c" /HighExp="T-0.40H, T0.0H, T0.30H, Salt, T-1.10H, T1.0H, T-1.40H, Etha, SMMPr, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S719" misc_feature complement(1942929..1942930) /Source="Nicolas_upshift_promotors" /id="U1539" /multdbtbs="-" /comp="M3" /sig="SigA" /pcomp="0.44955044955045" /psig="0.518481518481518" /xcortree=755 /SigmaFactorBS="cttgaggtttattgtaatgcatttcacggaaaatgtgttata atcagtttTAcaatacattacagtgcatttctttaatgagaaatgcataaaataaaaa a" /listShort="S718, S716" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(1943046..1943888) /gene="yobJ" /locus_tag="BSU_18980" /old_locus_tag="BSU18980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11866510" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function; putative defective prophage 6" /protein_id="NP_389779.1" /db_xref="EnsemblGenomes-Gn:BSU18980" /db_xref="EnsemblGenomes-Tr:CAB13790" /db_xref="GOA:O34774" /db_xref="SubtiList:BG13502" /db_xref="UniProtKB/Swiss-Prot:O34774" /translation="MELLDIWNWIQQNGILTAVITGIVALLFNQRQKSIERFYSQSGE TLEKILEPMYYSLKEIKNEEDENHKMVLIEKFFEEYSGKKGKLSKLRNILLIDQILNT EDCFREYILNKNSENRKKLFYKMRMLDQAVNKEYRSIFVTLNKNYNWYKVLFRTNYIL SAVFVFVRWFKETLAFFVGASAFAFIPLLYDKYLGEQVLGNWLEVNKLIFGLSCSALY IFWIIHYFLLKDTMQRKDEISLFQEWFDKTKLGKWTNKNVWGKIGNWNVERRARRVRN DEDV*" gene complement(1943046..1943888) /gene="yobJ" /locus_tag="BSU_18980" /old_locus_tag="BSU18980" promotor_-35 1943383..1943386 /Source="Nicolas_upshift_promotors" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1943396 /Source="Nicolas_upshifts" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1943402..1943406 /Source="Nicolas_upshift_promotors" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1943914..1943929) /Source="Nicolas_upshift_promotors" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" /label="promotor_-10" upshifts complement(1943915) /Source="Nicolas_upshifts" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" S_feature complement(1943917..1943999) /Source="Nicolas_S_feature" /locus_tag="new_2071115_2071197_c" /HighExp="MG 150, T-3.40H, Cold, SMM, Lbstat, SMMPr, ferm, T-2.40H, Fru, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S720" promotor_-35 complement(1943941..1943950) /Source="Nicolas_upshift_promotors" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" /label="promotor_-35" S_feature complement(1944001..1944087) /Source="Nicolas_S_feature" /locus_tag="new_2071199_2071285_c" /HighExp="Lbstat, M0t90, HiOs, HiTm, M40t90, dia15, S2, S1, T-0.40H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S721" downshifts complement(1944044) /Source="Nicolas_upshifts" /id="D1043" /incds=0 /nref=5 /ntot=191 /MaxReadThrough="4.07519" /MaxDrop="4.09712" /score="-3.79237769" /energy="-8.4" /TU="U1542" /idTUdmin="U1542" /TUdmin="-110" /isTUend="FALSE" CDS complement(1944088..1944546) /gene="rttM" /locus_tag="BSU_18990" /old_locus_tag="BSU18990" /function="17.2: Prophage functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin inhibiting Rnase RttL" /protein_id="NP_389780.1" /db_xref="EnsemblGenomes-Gn:BSU18990" /db_xref="EnsemblGenomes-Tr:CAB13791" /db_xref="InterPro:IPR018958" /db_xref="PDB:2PRV" /db_xref="SubtiList:BG13503" /db_xref="UniProtKB/Swiss-Prot:O34596" /translation="MIYSKVENFINENKQNAIFTEGASHENIGRIEENLQCDLPNSYK WFLEKYGAGGLFGVLVLGYNFDHASVVNRTNEYKEHYGLTDGLVVIEDVDYFAYCLDT NKMKDGECPVVEWDRVIGYQDTVADSFIEFFYNKIQEAKDDWDEDEDWDD*" gene complement(1944088..1944546) /gene="rttM" /locus_tag="BSU_18990" /old_locus_tag="BSU18990" CDS complement(1944556..1946358) /gene="rttL" /locus_tag="BSU_19000" /old_locus_tag="BSU19000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phage toxin ribonuclease; putative defective prophage 6" /protein_id="NP_389781.1" /db_xref="EnsemblGenomes-Gn:BSU19000" /db_xref="EnsemblGenomes-Tr:CAB13792" /db_xref="GOA:O34330" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR026834" /db_xref="SubtiList:BG13504" /db_xref="UniProtKB/Swiss-Prot:O34330" /translation="MKVFEADSLLFEADKRTKEYKELRSQMVKLKKAFKEVANLDDSE FSGKGADNIKAFYHGHVGVTDQWIDLIDMKIAFLSSMSATLEDAKMSDAYIEESFLEH ELANAYAKSKSIMSEQKKAMKDILNNINDILPLEIFSTEDFKDKLSSADDKREKTIDK LNKLDEDLKTEYAETEPNEQFIQQDFKKLQESTGKGKNATPIHYNAKAYRESDIHKKK GDIEKHSEAYLSVKKEEAKEREIKELKKKLNDGVSDPDEYLEIAKKVGYENLEPTQVQ LAVQIEQAKQLEGAGEITWDIVKGVGVGLYDVGKDTVTGIWDFITDPGETLSALGNAA MHPVKTYDAISAAIEESYQKDMVNGDAYSRSRWVTYAIGSVAVAVVGTKGAGAINKAD AAGKVINKASQAGKKIKDVKIPDLLPYNPKYKLALADNVPYNVVDSQNLKNELLTNAK KIPDGTRKPFTGQKKSPPWLNKEKYDAYEIEGKVKAKGKVKDVSRRVYTMKDIDINQK TEFGVTNLQLMKNGNAPYAKDGTQINLHHLIQEEPGPMLEIPNSLHTKYSDVIHQLKS DGESFRNDKVLKAQYESFRKRYWKWRAKQFENEN*" gene complement(1944556..1946358) /gene="rttL" /locus_tag="BSU_19000" /old_locus_tag="BSU19000" promotor_-10 complement(1946382..1946401) /Source="Nicolas_upshift_promotors" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" /label="promotor_-10" upshifts complement(1946398) /Source="Nicolas_upshifts" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" promotor_-35 complement(1946413..1946420) /Source="Nicolas_upshift_promotors" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" /label="promotor_-35" CDS complement(1946460..1947017) /gene="yobM" /locus_tag="BSU_19010" /old_locus_tag="BSU19010" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="NP_389782.3" /db_xref="EnsemblGenomes-Gn:BSU19010" /db_xref="EnsemblGenomes-Tr:CAB13793" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG13505" /db_xref="UniProtKB/Swiss-Prot:O34377" /translation="MTNFVHKTVNGLKSLLDEKGAIKLFCSEGDIMEFLVTFSQDKAT LNDIQSFEAKHQLTLPQDYQKFMTLHNGAKIFEILSDGENIGGGLQLFSLEEIEEELK YEDLFEDINGIPIGYLLEECHLMIDKDKVNQGDPNYLYIFESGLEYNPLNLNFEKFLD RYILANGEPFWDWRYYTAENYYRTR*" gene complement(1946460..1947017) /gene="yobM" /locus_tag="BSU_19010" /old_locus_tag="BSU19010" S_feature complement(1947024..1947419) /Source="Nicolas_S_feature" /locus_tag="new_2074222_2074617_c" /HighExp="M0t90, LoTm, M40t90, Lbstat, LBGstat, M9-stat, T0.30H, T2.30H, T1.0H, T2.0H" /AntisenseName="yobN" /AntisenseCor="-6.3634699133798794E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S722" promotor_-35 1947082..1947087 /Source="Nicolas_upshift_promotors" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" /label="promotor_-35" promotor_-10 1947103..1947121 /Source="Nicolas_upshift_promotors" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" /label="promotor_-10" upshifts 1947112 /Source="Nicolas_upshifts" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" S_feature 1947114..1947240 /Source="Nicolas_S_feature" /locus_tag="new_2074312_2074438" /HighExp="S3, S4, S5, S6, M9-stat, S8, S7, T5.0H, T4.0H, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S723" CDS 1947145..1948581 /gene="yobN" /locus_tag="BSU_19020" /old_locus_tag="BSU19020" /EC_number="1.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amine oxidase (flavoprotein)" /protein_id="NP_389783.2" /db_xref="EnsemblGenomes-Gn:BSU19020" /db_xref="EnsemblGenomes-Tr:CAB13794" /db_xref="GOA:O34363" /db_xref="InterPro:IPR001613" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13506" /db_xref="UniProtKB/Swiss-Prot:O34363" /translation="MNSLMNDDMVKIIRNGLSASQHPKHILVIGAGLSGLVSASLLKN AGHRVTILEASGRAGGRVCTLRSPFSDDLYFNAGPMRIPNNHSLTLEYIKKFKLPTNV FINRTPMDIIYANGIKTRLQVFERAPGILRYPVAPNEQGKTSEELMLSLLQPILNFIN QNPARNWRIVEEQYKNHSLSSFLNTYFSYGAIDMIGVLLDMEAYMGMSLVEVLRESIF FSSPAHFYEITGGMDLLPHAFLPQLKTNILYHQKMMKMSQGENRVTIHCQHQQTAEFT SFTADLAIVTIPFSTLRFVKVEPYHSFSYYKRRAIRELNYISATKIGIEFKSRFWEKA GQHGGKSITDLPIRFSYYPSRNIGANGHAVILASYTWADEALIWDSLSEGERIQYTLL NLSEIYGDIVWSEFVSGTSFSWSQYPYSAGGFTAFEPGQELELYPYIPVPEGRVHFAG EHASLTHAWMQGAIESGIRVAYEVNRLP*" gene 1947145..1948581 /gene="yobN" /locus_tag="BSU_19020" /old_locus_tag="BSU19020" promotor_-10 complement(1947405..1947424) /Source="Nicolas_upshift_promotors" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1947419) /Source="Nicolas_upshifts" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" promotor_-35 complement(1947438..1947444) /Source="Nicolas_upshift_promotors" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1948582..1948913 /Source="Nicolas_S_feature" /locus_tag="new_2075780_2076111" /HighExp="S3, S8, S4, S5, S7, M9-stat, S6, T5.0H, C30, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S724" promotor_-35 1948895..1948903 /Source="Nicolas_upshift_promotors" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1948914..1948932 /Source="Nicolas_upshift_promotors" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1948915..1949007 /Source="Nicolas_S_feature" /locus_tag="new_2076113_2076205" /HighExp="M9-stat, T1.30H, T2.0H, S2, T2.30H, Lbstat, BC, T0.30H, T3.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S725" upshifts 1948915 /Source="Nicolas_upshifts" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" CDS 1949008..1951428 /gene="yobO" /locus_tag="BSU_19030" /old_locus_tag="BSU19030" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11562162, 19450535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage-related pre-neck appendage protein; defective prophage 6" /protein_id="NP_389784.1" /db_xref="EnsemblGenomes-Gn:BSU19030" /db_xref="EnsemblGenomes-Tr:CAB13795" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR021865" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG13507" /db_xref="UniProtKB/Swiss-Prot:O34433" /translation="MVHFKNCPDPSLNANSQSHPEFSSELEHIKTRMQNFIKHSVTDQ NIEVTDARVTAEGEVTSLLKERLDKEYYRLLSKITREVNVADFGAVPDGRDNTEAFRK AIGNGRVKVHVPAGEYLVQGIKLPSWTTIVGQGKGITVIKLHEDTPAHEWVITNDDYQ NGNRNIFVQGMSLDWNPSRQCGVRNPGGQFSSCLTFAKVEYGWIKDVEAINAGLHGID ITSPTYDHLPDTDWTKDGSRYIWIDNCVTYGSGDDGITTHYSEYIFISNCHSGNPRGT EFAEGVSNSNGIEIDDGSRHVWLLNNFTSGNIRGVEVKAHELWPASQNVHIIGHISYR DVRAFDLRHIGHHQITDPESTTAYDVTLIDCSAVEPVFNSLYDAVTPRALVISAYKNV NVSGFTAIGDPDYDYKENPVVALQYRSQNITINGIKIRGFKKAGVDINLSGGSNKTDY IKISNFDIYKSAPKGISIGGGLYNVNILNGTMITDNGTVAIQSPNNQATILGVQSEGY SVAASIKGQTYQQVPINLKGGIQLATTSGFAVNQTSAVIAGTGDITARGERNAVISSS GGSSTEGSRALIASSNNAHIRGNQASRTILSSENIILEEPYTVAGGHQSIKWLLDSVR GNGTFAGAISSSLGGYGEYFESSTGQLIHTGTIVTLRGEKIVPANVGDYMLGVISETS AFISGASSFVWQGRYLTNEFGGFIYETVTDEESGELIRVPKQNPDYDTALEANYHSRA ARDEWHVVGLVGQHYVRIDETVNQGDYLTAHNGIGTKATEGSWKVMKITSAYTSEKGY GIALTVIK*" gene 1949008..1951428 /gene="yobO" /locus_tag="BSU_19030" /old_locus_tag="BSU19030" S_feature complement(1951350..1951985) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" S_feature 1951429..1951886 /Source="Nicolas_S_feature" /locus_tag="new_2078627_2079084" /HighExp="M9-stat, Lbstat, BC, T1.30H, S2, T0.30H, T2.0H, T3.0H, T2.30H, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S727" promotor_-35 1951861..1951868 /Source="Nicolas_upshift_promotors" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1951880..1951899 /Source="Nicolas_upshift_promotors" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1951888..1951998 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" upshifts 1951888 /Source="Nicolas_upshifts" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" misc_RNA 1951898..1952005 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" gene 1951898..1952005 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" downshifts 1951983 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" CDS complement(1952016..1952348) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" gene complement(1952016..1952348) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" downshifts complement(1952030) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" CDS complement(1952413..1953138) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" gene complement(1952413..1953138) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" CDS complement(1953153..1953896) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" gene complement(1953153..1953896) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" promotor_-10 complement(1953924..1953943) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1953943) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" promotor_-35 complement(1953957..1953963) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1953974..1954549) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" gene complement(1953974..1954549) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" CDS complement(1954555..1955256) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" gene complement(1954555..1955256) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" promotor_-10 complement(1955286..1955305) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1955286) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" promotor_-10 complement(1955290..1955305) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1955320..1955327) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1955320..1955327) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1955330) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" CDS complement(1955333..1955815) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" gene complement(1955333..1955815) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" misc_feature complement(1955854..1955871) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1955858) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" CDS complement(1955869..1956810) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" gene complement(1955869..1956810) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" downshifts complement(1955902) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" promotor_-10 complement(1956840..1956859) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1956848) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" promotor_-35 complement(1956873..1956877) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1956881..1956890 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1956903..1956922 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1956911 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" S_feature 1956926..1956990 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 1956962..1956967 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1956983..1957001 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1956992 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" CDS 1957016..1957561 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" gene 1957016..1957561 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" downshifts 1957520 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" CDS complement(1957588..1957911) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" gene complement(1957588..1957911) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" downshifts complement(1957595) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" promotor_-10 complement(1957932..1957951) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1957943) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" promotor_-35 complement(1957964..1957971) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1958032..1958038 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1958049 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" promotor_-10 1958053..1958072 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1958105..1958782 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" gene 1958105..1958782 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" downshifts 1958774 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" CDS complement(1958872..1959408) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" gene complement(1958872..1959408) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" downshifts complement(1958895) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(1959435..1959454) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1959455) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" promotor_-35 complement(1959468..1959475) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1959545..1960327) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" gene complement(1959545..1960327) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" downshifts complement(1959554) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" promotor_-10 complement(1960349..1960367) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1960368) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" promotor_-35 complement(1960381..1960387) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1960424..1960431 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1960446..1960465 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1960450 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" CDS 1960498..1960995 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" gene 1960498..1960995 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" promotor_-35 1961002..1961005 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1961021..1961040 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1961023 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" CDS 1961059..1962036 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" gene 1961059..1962036 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" downshifts 1962008 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" promotor_-35 1962133..1962140 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1962155..1962174 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1962162 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" CDS 1962198..1963256 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" gene 1962198..1963256 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" S_feature 1963257..1963326 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 1963310..1963316 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1963328..1963347 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1963328 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" CDS 1963376..1964488 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" gene 1963376..1964488 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" CDS 1964507..1965106 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" gene 1964507..1965106 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" downshifts 1965044 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" downshifts 1965088 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" S_feature complement(1965128..1965626) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(1965164) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" promotor_-35 1965598..1965607 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1965610..1965628) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1965619..1965813 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 1965619 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" promotor_-10 1965620..1965639 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1965626) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" promotor_-35 complement(1965645..1965650) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1965701..1966564) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" gene complement(1965701..1966564) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" downshifts complement(1965714) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" downshifts 1965770 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" downshifts complement(1965802) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" S_feature 1965815..1966582 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 1966560..1966564 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1966573..1966587 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1966584 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1966603..1966622) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1966616) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" S_feature complement(1966618..1966811) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(1966634..1966640) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1966812..1968587) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" gene complement(1966812..1968587) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" S_feature complement(1968588..1968718) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(1968711..1968913) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" gene complement(1968711..1968913) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" downshifts complement(1968763) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" promotor_-10 complement(1968911..1968930) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(1968929) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" S_feature complement(1968931..1969123) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(1968943..1968950) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(1969152..1969778) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" gene complement(1969152..1969778) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" downshifts complement(1969168) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" promotor_-10 complement(1969812..1969831) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(1969825) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" promotor_-35 complement(1969845..1969852) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(1969928..1970419) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" gene complement(1969928..1970419) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" downshifts complement(1969937) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1970431..1970449) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(1970443) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" promotor_-35 complement(1970463..1970469) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(1970494..1970826) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" gene complement(1970494..1970826) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" S_feature complement(1970827..1971117) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 1970842..1970847 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 1970862..1970880 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 1970864 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" CDS 1970904..1971131 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" gene 1970904..1971131 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" CDS complement(1971118..1971594) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" gene complement(1971118..1971594) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" S_feature 1971132..1971639 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(1971595..1971697) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 1971612..1971617 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1971632..1971650 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1971641 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" CDS 1971661..1971924 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" gene 1971661..1971924 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" promotor_-10 complement(1971677..1971696) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1971697) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" S_feature complement(1971699..1972224) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(1971710..1971714) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1971929..1972162 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" gene 1971929..1972162 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" downshifts 1972149 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" CDS complement(1972248..1972592) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" gene complement(1972248..1972592) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" downshifts complement(1972269) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" S_feature complement(1972593..1972665) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(1972661..1972680) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1972665) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" S_feature complement(1972667..1972770) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(1972694..1972699) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1972757..1972772) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1972770) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" promotor_-35 complement(1972785..1972794) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1972913) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" CDS complement(1972949..1973152) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" gene complement(1972949..1973152) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" promotor_-10 complement(1973173..1973192) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1973191) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" S_feature complement(1973193..1973259) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(1973208..1973215) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1973225..1973232 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 1973244 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" misc_feature complement(1973246..1973258) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1973246..1973265 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 1973249..1973381 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(1973270) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" CDS 1973382..1974869 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" gene 1973382..1974869 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" promotor_-10 complement(1973825..1973842) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1973831) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1973855..1973863) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1974855 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" promotor_-35 1974917..1974922 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1974938..1974956 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1974943 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" CDS 1974970..1976868 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" gene 1974970..1976868 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" promotor_-10 complement(1975913..1975932) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1975921) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1975946..1975955) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1976858..1977703 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" gene 1976858..1977703 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" S_feature 1977704..1979210 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(1977736..1979073) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" gene complement(1977736..1979073) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" downshifts complement(1977747) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" promotor_-10 complement(1979101..1979120) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1979116) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" S_feature complement(1979118..1980276) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(1979135..1979142) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1979194..1979197 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1979212..1979231 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1979212 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" CDS 1979292..1980257 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" gene 1979292..1980257 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" downshifts 1980245 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" CDS complement(1980307..1981560) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" gene complement(1980307..1981560) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" downshifts complement(1980321) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" CDS complement(1981576..1984410) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" gene complement(1981576..1984410) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" promotor_-10 complement(1984505..1984524) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1984520) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" S_feature complement(1984522..1984638) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(1984539..1984546) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1984639..1986555) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" gene complement(1984639..1986555) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" CDS complement(1986566..1987480) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" gene complement(1986566..1987480) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" promotor_-10 complement(1987484..1987503) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(1987499) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" promotor_-35 complement(1987520..1987524) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(1987544..1988134) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" gene complement(1987544..1988134) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" CDS complement(1988227..1989471) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" gene complement(1988227..1989471) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" downshifts complement(1988229) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" promotor_-10 complement(1989534..1989552) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1989547) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" S_feature complement(1989549..1989769) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(1989565..1989572) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1989755..1989773) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1989769) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" promotor_-35 complement(1989785..1989793) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1989853..1991070) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" gene complement(1989853..1991070) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" downshifts complement(1989879) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1991103..1991122) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1991111) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" promotor_-35 complement(1991136..1991143) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1991306..1991929) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" gene complement(1991306..1991929) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" S_feature complement(1991930..1992080) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 1991956..1991962 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1991968 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" promotor_-10 1991976..1991987 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1991994..1992002 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1992010..1992110 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 1992014..1992032 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1992025 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1992063..1992081) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1992070..1992155 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 1992070 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" upshifts complement(1992080) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" promotor_-35 complement(1992097..1992103) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1992131..1992138 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1992151..1992170 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1992157 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" CDS 1992195..1993553 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" gene 1992195..1993553 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" promotor_-10 complement(1992537..1992548) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1992542) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1992562..1992568) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1993569..1994417 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" gene 1993569..1994417 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" promotor_-10 complement(1993833..1993852) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1993840) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1993866..1993874) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1994380 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" downshifts complement(1994412) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" CDS complement(1994443..1995108) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" gene complement(1994443..1995108) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" downshifts complement(1994457) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" CDS complement(1995127..1995477) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" gene complement(1995127..1995477) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" CDS complement(1995474..1995752) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" gene complement(1995474..1995752) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" promotor_-10 complement(1995779..1995798) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1995795) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" promotor_-35 complement(1995813..1995819) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1995828..1996724) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" gene complement(1995828..1996724) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" promotor_-35 1996566..1996575 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1996586 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" promotor_-10 1996589..1996608 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1996604..1996822 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(1996748..1996767) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1996768) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" promotor_-35 complement(1996779..1996786) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1996823..1997296 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" gene 1996823..1997296 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" downshifts 1997293 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" CDS complement(1997331..1997567) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" gene complement(1997331..1997567) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" downshifts complement(1997339) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" promotor_-10 complement(1997590..1997609) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1997605) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" promotor_-35 complement(1997623..1997632) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1997652..1998986) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" gene complement(1997652..1998986) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" S_feature complement(1998987..1999122) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(1999119..1999138) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1999129) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" promotor_-35 complement(1999153..1999160) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1999218..1999225 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1999240..1999259 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1999243 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" S_feature 1999244..1999350 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 1999351..1999740 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" gene 1999351..1999740 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" downshifts 1999750 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" CDS complement(2000147..2000485) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" gene complement(2000147..2000485) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" promotor_-35 2000508..2000515 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2000529..2000548 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2000538 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" S_feature 2000542..2000614 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(2000573..2000592) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2000576) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" promotor_-35 complement(2000604..2000610) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2000615..2001223 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" gene 2000615..2001223 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" downshifts 2001213 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" CDS complement(2001266..2001868) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" gene complement(2001266..2001868) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" CDS complement(2001884..2002795) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" gene complement(2001884..2002795) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" promotor_-10 complement(2002824..2002843) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2002840) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" promotor_-35 complement(2002859..2002864) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2002916..2002919 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2002934..2002953 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2002936 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" CDS 2002979..2003179 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" gene 2002979..2003179 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" CDS 2003179..2004669 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" gene 2003179..2004669 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" promotor_-10 complement(2003914..2003925) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2003918) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2003939..2003945) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2004657 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" CDS complement(2004704..2006104) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" gene complement(2004704..2006104) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" downshifts complement(2004728) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" promotor_-35 2005875..2005884 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2005896..2005911 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2005910 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2006124..2006143) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2006144) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" promotor_-35 complement(2006157..2006164) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2006203..2006212 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2006218 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" promotor_-10 2006225..2006244 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2006257..2006958 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" gene 2006257..2006958 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" promotor_-35 2006983..2006991 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2007005..2007024 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2007010 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" CDS 2007046..2007297 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" gene 2007046..2007297 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" downshifts 2007318 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" CDS complement(2007368..2008189) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" gene complement(2007368..2008189) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" downshifts complement(2007394) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" S_feature complement(2008190..2008271) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(2008272..2008973) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" gene complement(2008272..2008973) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" S_feature complement(2008974..2009063) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(2009048..2009067) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2009063) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" promotor_-35 complement(2009083..2009087) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2009121..2009127 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2009142..2009153 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2009159 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" CDS 2009175..2009300 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" gene 2009175..2009300 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" downshifts 2009298 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" CDS complement(2009340..2009654) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" gene complement(2009340..2009654) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" downshifts complement(2009352) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2009675..2009693) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2009682) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" promotor_-35 complement(2009704..2009712) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2009715..2010326) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" gene complement(2009715..2010326) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" CDS complement(2010404..2010580) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" gene complement(2010404..2010580) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" downshifts complement(2010408) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" upshifts complement(2010419) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" promotor_-10 complement(2010423..2010442) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2010458..2010461) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2010594..2010612) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(2010615) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" S_feature complement(2010617..2010838) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(2010628..2010633) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 2010638..2010643 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2010658..2010676 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2010660 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" CDS 2010699..2010842 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" gene 2010699..2010842 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" CDS complement(2010839..2011519) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" gene complement(2010839..2011519) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" S_feature 2010843..2011854 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(2011546..2011565) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2011552) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" promotor_-35 complement(2011579..2011588) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2011670..2011894) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" gene complement(2011670..2011894) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" downshifts complement(2011684) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" misc_feature complement(2011935..2011954) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2011947) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" CDS complement(2011981..2012259) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" gene complement(2011981..2012259) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" CDS complement(2012256..2013671) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" gene complement(2012256..2013671) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" promotor_-35 2012927..2012930 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2012946..2012965 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2012951 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2013700..2014527) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " gene complement(2013700..2014527) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" CDS complement(2014505..2015815) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" gene complement(2014505..2015815) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" CDS complement(2015824..2016477) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " gene complement(2015824..2016477) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" CDS complement(2016462..2017151) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" gene complement(2016462..2017151) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" CDS complement(2017158..2018492) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" gene complement(2017158..2018492) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" CDS complement(2018473..2018628) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" gene complement(2018473..2018628) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" promotor_-10 complement(2018511..2018529) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2018527) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" promotor_-35 complement(2018545..2018550) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2018622..2018855) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" gene complement(2018622..2018855) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" downshifts complement(2018629) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" promotor_-35 2018731..2018735 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2018744..2018758 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2018759 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2018760..2018779) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2018769) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" promotor_-35 complement(2018794..2018803) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2018815..2019594) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" gene complement(2018815..2019594) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" CDS complement(2019623..2020903) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" gene complement(2019623..2020903) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" promotor_-10 complement(2020271..2020289) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2020287) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" promotor_-35 complement(2020303..2020310) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2020871..2020889) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2020881) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" promotor_-35 complement(2020905..2020910) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2020968..2021273) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " gene complement(2020968..2021273) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" downshifts complement(2021101) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" promotor_-10 complement(2021297..2021316) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(2021312) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" promotor_-35 complement(2021330..2021339) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 2021409..2021418 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2021432..2021451 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2021432 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" upshifts complement(2021453) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2021455..2021469) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2021478..2021482) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2021478..2021879 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" gene 2021478..2021879 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" CDS 2021886..2022839 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" gene 2021886..2022839 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" downshifts 2022829 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" CDS complement(2022910..2024058) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" gene complement(2022910..2024058) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" downshifts complement(2022927) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" promotor_-35 2024071..2024075 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2024084..2024103) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 2024091..2024110 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2024093) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts 2024101 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 2024362..2024370 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2024384..2024403 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2024387 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" CDS 2024428..2025453 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 2024428..2025453 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 2024831 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" SCAR 2024847..2024848 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 2025445 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" CDS complement(2025497..2025928) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" gene complement(2025497..2025928) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" downshifts complement(2025502) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" CDS complement(2025929..2026462) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" gene complement(2025929..2026462) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" promotor_-35 2026466..2026472 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2026483..2026593 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 2026483 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" promotor_-10 2026485..2026504 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2026490..2026509) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2026510) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" promotor_-35 complement(2026525..2026526) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2026594..2027019 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" gene 2026594..2027019 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" downshifts 2027007 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" S_feature 2027052..2028283 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(2027069..2028406) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" gene complement(2027069..2028406) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" CDS complement(2028478..2028672) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" gene complement(2028478..2028672) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" downshifts complement(2028491) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" CDS complement(2028685..2029248) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" gene complement(2028685..2029248) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" CDS complement(2029258..2030025) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" gene complement(2029258..2030025) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" promotor_-10 complement(2030049..2030068) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2030066) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" promotor_-35 complement(2030079..2030086) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2030103..2030684) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" gene complement(2030103..2030684) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" S_feature complement(2030685..2030800) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(2030832..2031083) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" gene complement(2030832..2031083) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" downshifts complement(2030845) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" misc_feature complement(2031106..2031125) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2031120) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" CDS complement(2031169..2032437) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" gene complement(2031169..2032437) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" promotor_-10 complement(2032471..2032490) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2032490) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" promotor_-35 complement(2032502..2032509) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2032644..2032663 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2032647 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" CDS 2032686..2033681 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" gene 2032686..2033681 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" CDS 2033702..2034343 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" gene 2033702..2034343 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" S_feature 2034344..2035445 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(2034382..2035002) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" gene complement(2034382..2035002) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" downshifts complement(2034408) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" CDS complement(2035003..2035509) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" gene complement(2035003..2035509) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" CDS complement(2035506..2036300) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" gene complement(2035506..2036300) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" CDS complement(2036384..2036917) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" gene complement(2036384..2036917) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" downshifts complement(2036389) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" promotor_-35 2036847..2036852 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2036863..2037809 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 2036865 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" promotor_-10 2036869..2036887 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2036935..2037546) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" gene complement(2036935..2037546) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" promotor_-10 complement(2037578..2037597) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2037597) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" promotor_-35 complement(2037610..2037615) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2037766 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" CDS complement(2037806..2038579) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" gene complement(2037806..2038579) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" downshifts complement(2037841) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" CDS complement(2038621..2039055) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" gene complement(2038621..2039055) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" downshifts complement(2038633) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" promotor_-10 complement(2039084..2039103) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(2039095) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" S_feature complement(2039097..2039161) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(2039117..2039124) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(2039140) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" CDS complement(2039162..2040838) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" gene complement(2039162..2040838) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" S_feature complement(2040839..2041029) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(2041018..2041037) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2041029) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" promotor_-35 complement(2041052..2041055) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2041127..2042260) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" gene complement(2041127..2042260) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" downshifts complement(2041143) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" misc_feature complement(2042282..2042301) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2042285) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" CDS complement(2042320..2042937) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" gene complement(2042320..2042937) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" CDS complement(2042953..2043435) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" gene complement(2042953..2043435) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" S_feature complement(2043436..2043583) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(2043574..2043592) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(2043584) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" promotor_-35 complement(2043603..2043611) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 2043637..2043646 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 2043659..2043674 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 2043661..2043747 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 2043661 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" promotor_-35 2043710..2043717 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 2043732..2043751 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 2043749 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" CDS 2043778..2044683 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" gene 2043778..2044683 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" misc_feature 2044718..2044737 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2044732 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" S_feature 2044733..2044913 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 2044914..2046062 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" gene 2044914..2046062 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" S_feature complement(2045083..2046112) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 2046058 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2046094..2046113) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2046112) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" promotor_-35 complement(2046128..2046136) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2046143..2046289 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" gene 2046143..2046289 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" promotor_-35 2046182..2046189 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2046203..2046222 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2046214..2046304 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 2046214 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" CDS 2046305..2046505 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" gene 2046305..2046505 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" downshifts 2046520 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" CDS complement(2046557..2046739) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" gene complement(2046557..2046739) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" S_feature 2046565..2046870 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(2046574) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(2046800..2046818) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2046832..2046838) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2046836) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" promotor_-35 2046846..2046852 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2046867..2046878 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2046872 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" CDS 2046895..2047164 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" gene 2046895..2047164 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" downshifts 2047019 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" downshifts 2047147 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" CDS complement(2047192..2047374) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" gene complement(2047192..2047374) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" downshifts complement(2047212) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" CDS complement(2047367..2048047) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" gene complement(2047367..2048047) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" S_feature complement(2048048..2048185) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 2048064..2048069 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2048082..2048101 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2048087 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" CDS 2048130..2048819 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" gene 2048130..2048819 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" promotor_-10 complement(2048180) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2048183..2048199) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2048186) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" S_feature complement(2048187..2048576) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(2048557..2048576) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2048574) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" promotor_-35 complement(2048588..2048596) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2048819..2049217 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" gene 2048819..2049217 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" promotor_-35 2049210..2049216 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2049231..2049242 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2049242 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" CDS 2049259..2049387 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" gene 2049259..2049387 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" S_feature 2049388..2050368 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(2049395..2050285) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" gene complement(2049395..2050285) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" downshifts complement(2049432) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" promotor_-10 complement(2050307..2050326) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2050314) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" promotor_-35 complement(2050338..2050344) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2050342 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" CDS complement(2050386..2050532) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" gene complement(2050386..2050532) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" downshifts complement(2050402) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" upshifts complement(2050556) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" promotor_-10 complement(2050557..2050568) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2050583..2050589) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2050607..2050864) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" gene complement(2050607..2050864) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" promotor_-10 complement(2050884..2050903) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2050899) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" promotor_-35 complement(2050915..2050922) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2050929..2054510) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" gene complement(2050929..2054510) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" S_feature complement(2054511..2054582) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(2054572..2054591) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2054582) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" S_feature complement(2054627..2054824) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(2054670) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" CDS complement(2054686..2054775) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" gene complement(2054686..2054775) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" promotor_-10 complement(2054803..2054822) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2054824) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" promotor_-35 complement(2054837..2054844) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2054846..2055352) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" gene complement(2054846..2055352) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" CDS complement(2055356..2056453) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" gene complement(2055356..2056453) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" promotor_-10 complement(2056471..2056482) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2056474) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" promotor_-35 complement(2056497..2056503) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2056527..2057843) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" gene complement(2056527..2057843) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" downshifts complement(2056540) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" CDS complement(2057840..2058424) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" gene complement(2057840..2058424) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" misc_RNA complement(2058513..2058613) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" gene complement(2058513..2058613) /gene="gswA" /locus_tag="BSU_misc_RNA_34" downshifts complement(2058520) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" S_feature complement(2058614..2058754) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(2058755..2060260) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" gene complement(2058755..2060260) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" promotor_no_box complement(2060196..2060296) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2060236) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" downshifts 2060248 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" promotor_-10 complement(2060286..2060305) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2060302) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" promotor_-35 complement(2060319..2060326) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2060372..2061364) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" gene complement(2060372..2061364) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" downshifts complement(2060390) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" CDS complement(2061409..2061999) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" gene complement(2061409..2061999) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" CDS complement(2062001..2062975) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" gene complement(2062001..2062975) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" CDS complement(2063013..2064032) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" gene complement(2063013..2064032) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" promotor_-10 complement(2064080..2064099) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2064090) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" promotor_-35 complement(2064111..2064118) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2064153..2064160 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2064174..2064253 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 2064174 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" promotor_-10 2064175..2064194 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2064254..2065081 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " gene 2064254..2065081 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" CDS 2065083..2065847 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" gene 2065083..2065847 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" downshifts 2065836 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" downshifts complement(2065878) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" CDS complement(2065888..2067813) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" gene complement(2065888..2067813) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" promotor_-10 complement(2067844..2067863) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2067848) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" S_feature complement(2067850..2067914) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(2067878..2067882) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2067915..2068106) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" gene complement(2067915..2068106) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" promotor_-10 complement(2068125..2068143) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2068134) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" S_feature complement(2068136..2068441) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(2068159..2068164) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2068173..2068179 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2068194..2068205 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2068203 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" CDS 2068270..2068422 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" gene 2068270..2068422 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" downshifts 2068432 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" CDS complement(2068475..2069632) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" gene complement(2068475..2069632) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" downshifts complement(2068486) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" misc_RNA complement(2069720..2070120) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2069720..2070120) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" downshifts complement(2069730) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" promotor_-10 complement(2070117..2070136) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2070135) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" promotor_-35 complement(2070151..2070157) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2070179..2070475) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" gene complement(2070179..2070475) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" promotor_-10 complement(2070500..2070519) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2070510) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" promotor_-35 complement(2070533..2070540) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2070553..2071182) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" gene complement(2070553..2071182) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" downshifts complement(2071148) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" CDS complement(2071184..2071411) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" gene complement(2071184..2071411) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" promotor_-10 complement(2071439..2071458) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(2071454) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" S_feature complement(2071456..2071610) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(2071472..2071480) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(2071495..2071623) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" gene complement(2071495..2071623) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" upshifts complement(2071610) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" S_feature complement(2071612..2071723) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(2071613..2071632) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(2071648..2071652) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2071724..2072965) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" gene complement(2071724..2072965) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" promotor_-10 complement(2072679..2072697) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(2072688) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" promotor_-35 complement(2072712..2072719) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(2072981..2075230) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" gene complement(2072981..2075230) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" promotor_-10 complement(2075246..2075265) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2075262) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" promotor_-35 complement(2075279..2075285) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2075333..2075839) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" gene complement(2075333..2075839) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" downshifts complement(2075356) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" promotor_-10 complement(2075883..2075902) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2075900) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" promotor_-35 complement(2075916..2075923) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 2075921..2075930 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2075944..2075963 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2075956 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" CDS 2075977..2076396 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" gene 2075977..2076396 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" S_feature 2076397..2076547 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(2076417..2076794) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" gene complement(2076417..2076794) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" downshifts complement(2076450) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" S_feature 2076792..2076937 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(2076824..2076842) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2076843) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" promotor_-35 complement(2076856..2076865) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2076938..2076957 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2076939 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" CDS 2076982..2077170 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" gene 2076982..2077170 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" downshifts 2077186 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" CDS complement(2077209..2077580) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" gene complement(2077209..2077580) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" downshifts complement(2077242) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2077592..2077611) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2077605) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" promotor_-35 complement(2077624..2077629) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2077626..2077871) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" gene complement(2077626..2077871) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" promotor_-10 complement(2077897..2077915) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2077902) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" promotor_-35 complement(2077927..2077935) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2078021..2078027 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2078042..2078053 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2078049 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" CDS 2078070..2078174 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" gene 2078070..2078174 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" downshifts 2078156 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" CDS complement(2078199..2079161) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" gene complement(2078199..2079161) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" promotor_-35 2078329..2078338 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2078350..2078365 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2078350 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" S_feature 2078354..2078689 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 2078660..2078664 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2078680..2078699 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2078691..2079201 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 2078691 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" S_feature complement(2079162..2079618) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 2079202..2079822 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" gene 2079202..2079822 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" promotor_-10 complement(2079607..2079618) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2079618) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" promotor_-35 complement(2079633..2079639) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2079844..2082588 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" gene 2079844..2082588 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" downshifts complement(2082258) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" downshifts 2082574 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" CDS complement(2082664..2083158) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" gene complement(2082664..2083158) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" downshifts complement(2082677) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" CDS complement(2083155..2083814) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" gene complement(2083155..2083814) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" CDS complement(2083833..2084531) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" gene complement(2083833..2084531) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" S_feature complement(2084532..2084623) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(2084624..2085916) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" gene complement(2084624..2085916) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" S_feature complement(2085917..2085978) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(2085978..2085997) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2085978) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" promotor_-35 complement(2086012..2086019) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2086060..2087241) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" gene complement(2086060..2087241) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" downshifts complement(2086064) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" CDS complement(2087264..2087749) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" gene complement(2087264..2087749) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" promotor_-10 complement(2087697..2087716) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2087714) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" promotor_-35 complement(2087729..2087736) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2087758..2087928) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" gene complement(2087758..2087928) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" S_feature complement(2087929..2088000) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 2087962..2087968 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2087983..2088002) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2087983..2087994 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2087990..2088064 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 2087990 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(2088000) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" S_feature complement(2088002..2088070) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(2088018..2088024) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2088034 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" CDS complement(2088071..2090866) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" gene complement(2088071..2090866) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" promotor_-35 2088539..2088543 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2088540 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2088545..2088549 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2089196..2089211) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(2089210) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" promotor_-35 complement(2089224..2089233) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(2090867..2090991) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(2090992..2091375) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" gene complement(2090992..2091375) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" CDS complement(2091377..2092237) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" gene complement(2091377..2092237) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" CDS complement(2092239..2093072) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" gene complement(2092239..2093072) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" S_feature complement(2093073..2093280) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(2093275..2093294) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2093280) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" promotor_-35 complement(2093311..2093315) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2093318..2094295) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" gene complement(2093318..2094295) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" CDS complement(2094280..2095473) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" gene complement(2094280..2095473) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" CDS complement(2095478..2096611) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" gene complement(2095478..2096611) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" CDS complement(2096608..2097318) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" gene complement(2096608..2097318) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" CDS complement(2097311..2097724) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" gene complement(2097311..2097724) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" CDS complement(2097740..2098543) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" gene complement(2097740..2098543) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" CDS complement(2098555..2098890) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" gene complement(2098555..2098890) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" promotor_-10 complement(2098910..2098929) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(2098920) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" promotor_-35 complement(2098943..2098950) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 2098959..2098966 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2098975..2098994) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 2098980..2098999 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2098986 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" upshifts complement(2098994) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" CDS 2099030..2099902 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" gene 2099030..2099902 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" CDS complement(2099944..2100738) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" gene complement(2099944..2100738) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" downshifts complement(2099969) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" S_feature complement(2100739..2100806) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(2100807..2101364) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" gene complement(2100807..2101364) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" S_feature complement(2101365..2101444) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(2101489) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" CDS complement(2101511..2102278) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" gene complement(2101511..2102278) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" CDS complement(2102313..2102987) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" gene complement(2102313..2102987) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" CDS complement(2102989..2103492) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" gene complement(2102989..2103492) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" downshifts 2103501 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" promotor_-10 complement(2103556..2103575) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2103556) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" promotor_-35 complement(2103590..2103597) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2103635..2104081) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" gene complement(2103635..2104081) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" downshifts 2104084 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" CDS complement(2104136..2104675) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" gene complement(2104136..2104675) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" downshifts complement(2104149) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2104708..2104726) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(2104719) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" promotor_-35 complement(2104738..2104746) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(2104747..2106018) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" gene complement(2104747..2106018) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" S_feature complement(2106019..2106086) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(2106083..2106102) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2106086) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" promotor_-35 complement(2106116..2106123) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2106153..2106172) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(2106159) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" S_feature complement(2106161..2106305) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(2106183..2106190) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(2106287..2106305) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(2106305) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" promotor_-35 complement(2106321..2106326) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(2106354..2107640) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" gene complement(2106354..2107640) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" downshifts complement(2106377) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" CDS complement(2107651..2108766) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" gene complement(2107651..2108766) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" CDS complement(2108815..2109897) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" gene complement(2108815..2109897) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" CDS complement(2109908..2110711) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" gene complement(2109908..2110711) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" promotor_-10 complement(2110396..2110415) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(2110413) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" promotor_-35 complement(2110427..2110434) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(2110704..2111906) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" gene complement(2110704..2111906) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" CDS complement(2111887..2112534) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" gene complement(2111887..2112534) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" downshifts complement(2111981) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" misc_feature complement(2112157..2112160) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2112157) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" downshifts complement(2112377) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" CDS complement(2112539..2113288) /gene="trpC" /locus_tag="BSU_22660" /old_locus_tag="BSU22660" /EC_number="4.1.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10627030, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10627030, 10714985, 12963367, 17114058; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /db_xref="GOA:P03964" /db_xref="InterPro:IPR001468" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013798" /db_xref="PSEUDO:CAB14182.3" /db_xref="SubtiList:BG11038" /db_xref="UniProtKB/Swiss-Prot:P03964" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASPNRFIGLIA EVKKASPSKGLIKEDFVPVQIAKDYEAAKADAISVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKGMDVLVEVHDAS TLEQILKVFTPDILGVNNRNLKTFETSVKQTEQIASLVPKESLLVSESGIGSLEHLTF VNEHGARAVLIGESLMRQTSQRKAIHALFRE*" gene complement(2112539..2113288) /gene="trpC" /locus_tag="BSU_22660" /old_locus_tag="BSU22660" /pseudo misc_feature complement(2112572..2112574) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2112575) /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" CDS complement(2113281..2114297) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" gene complement(2113281..2114297) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" CDS complement(2114269..2115816) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" gene complement(2114269..2115816) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" S_feature complement(2115895..2116026) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(2115938) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2116017..2116036) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(2116026) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" CDS complement(2116032..2116415) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" gene complement(2116032..2116415) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" promotor_-35 complement(2116051..2116058) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(2116412..2117500) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" gene complement(2116412..2117500) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" promotor_-10 complement(2116541..2116556) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(2116554) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" promotor_-35 complement(2116569..2116577) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(2117500..2118672) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" gene complement(2117500..2118672) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" promotor_-10 complement(2118707..2118726) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2118724) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" promotor_-35 complement(2118739..2118746) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2118747..2119517) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" gene complement(2118747..2119517) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" promotor_-10 complement(2119543..2119562) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2119560) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" promotor_-35 complement(2119574..2119580) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(2119592..2119753) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(2119635) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" CDS complement(2119754..2120203) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" gene complement(2119754..2120203) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" promotor_-10 complement(2120246..2120265) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(2120253) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" promotor_-35 complement(2120278..2120285) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(2120319..2121365) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" gene complement(2120319..2121365) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" CDS complement(2121307..2122008) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" gene complement(2121307..2122008) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" CDS complement(2122015..2122770) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" gene complement(2122015..2122770) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" S_feature complement(2122771..2122856) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(2122845..2122864) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2122856) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" promotor_-35 complement(2122875..2122882) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2122934..2123161) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" gene complement(2122934..2123161) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" downshifts complement(2122955) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" CDS complement(2123183..2123755) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" gene complement(2123183..2123755) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" promotor_-10 complement(2123784..2123803) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2123794) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" S_feature complement(2123796..2123879) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(2123816..2123822) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(2123924) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" CDS complement(2123943..2124221) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" gene complement(2123943..2124221) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" S_feature complement(2124222..2124447) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(2124429..2124448) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2124447) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" promotor_-35 complement(2124465..2124470) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2124595..2126073) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" gene complement(2124595..2126073) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" downshifts complement(2124608) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" S_feature complement(2126074..2126235) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(2126222..2126240) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(2126247) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" CDS complement(2126254..2126988) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" gene complement(2126254..2126988) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" promotor_-35 complement(2126255..2126260) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(2126280) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" CDS complement(2127010..2127213) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" gene complement(2127010..2127213) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" promotor_-10 complement(2127249..2127268) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2127270) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" promotor_-35 complement(2127282..2127289) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2127335..2127534) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(2127378) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" promotor_-10 complement(2127509..2127528) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2127534) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" promotor_-35 complement(2127542..2127551) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2127551..2128588) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" gene complement(2127551..2128588) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" CDS complement(2128606..2129916) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" gene complement(2128606..2129916) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" S_feature complement(2129917..2130041) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(2130027..2130046) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2130041) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" promotor_-35 complement(2130061..2130064) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2130070..2130264) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" gene complement(2130070..2130264) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" CDS complement(2130261..2131154) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" gene complement(2130261..2131154) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" CDS complement(2131151..2131750) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" gene complement(2131151..2131750) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" promotor_-35 2131623..2131629 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2131638..2131821 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 2131640 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" promotor_-10 2131643..2131654 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2131761..2131779) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2131780) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" promotor_-35 complement(2131795..2131800) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2131828..2131959 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " gene 2131828..2131959 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" downshifts 2131947 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" CDS complement(2132002..2133051) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" gene complement(2132002..2133051) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" downshifts complement(2132022) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" downshifts complement(2132926) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" CDS complement(2133064..2134212) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" gene complement(2133064..2134212) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" misc_feature 2133393..2133396 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2133420 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2133486 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" downshifts 2134190 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" S_feature complement(2134213..2134352) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(2134351..2134370) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2134352) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" S_feature complement(2134354..2134444) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(2134385..2134392) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2134445..2135119) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" gene complement(2134445..2135119) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" S_feature complement(2135120..2135197) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(2135198..2135374) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" gene complement(2135198..2135374) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" promotor_-10 complement(2135386..2135404) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2135403) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" promotor_-35 complement(2135419..2135425) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2135419..2136072) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " gene complement(2135419..2136072) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" promotor_-10 complement(2136102..2136121) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2136115) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" promotor_-35 complement(2136137..2136141) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2136165..2137517) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" gene complement(2136165..2137517) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" downshifts complement(2136180) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" CDS complement(2137552..2138469) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" gene complement(2137552..2138469) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" downshifts complement(2137940) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" misc_feature complement(2138091..2138098) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2138094) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" promotor_-10 complement(2138507..2138518) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2138516) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" promotor_-35 complement(2138532..2138538) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2138608..2139264) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" gene complement(2138608..2139264) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" downshifts complement(2138622) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" misc_feature complement(2139289..2139308) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2139304) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" CDS complement(2139384..2140358) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" gene complement(2139384..2140358) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" downshifts complement(2139392) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" promotor_-35 2140212..2140217 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2140233..2140251 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2140243..2140436 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 2140243 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" downshifts 2140394 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" CDS complement(2140467..2141750) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" gene complement(2140467..2141750) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" downshifts complement(2140470) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" promotor_-35 2140508..2140514 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2140526..2140530 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2140526 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2141793..2141812) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2141814) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" promotor_-35 complement(2141827..2141834) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2141906..2142490) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" gene complement(2141906..2142490) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" downshifts complement(2141908) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" S_feature complement(2142491..2142572) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(2142565..2142584) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(2142572) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" promotor_-35 complement(2142598..2142605) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(2142649..2143428) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" gene complement(2142649..2143428) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" promotor_-10 complement(2143454..2143469) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(2143465) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" promotor_-35 complement(2143481..2143490) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(2143514..2143957) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" gene complement(2143514..2143957) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" downshifts complement(2143531) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" CDS complement(2144020..2144742) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" gene complement(2144020..2144742) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" downshifts complement(2144301) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" CDS complement(2144693..2145262) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" gene complement(2144693..2145262) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" promotor_-10 complement(2145011..2145029) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2145027) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" promotor_-35 complement(2145044..2145050) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2145281..2146027 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(2145322..2146812) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" gene complement(2145322..2146812) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" CDS complement(2146805..2147863) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" gene complement(2146805..2147863) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" promotor_-35 2147153..2147162 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2147173..2147963 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 2147173 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" promotor_-10 2147175..2147194 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2147904..2147923) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2147927) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" promotor_-35 complement(2147935..2147942) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2147941..2147947 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 2147961..2147980 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 2147965..2148034 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 2147965 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" promotor_-35 2148014..2148021 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2148036..2148128 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 2148036..2148055 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2148036 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" CDS 2148129..2148377 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" gene 2148129..2148377 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" downshifts 2148361 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" CDS complement(2148417..2148989) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" gene complement(2148417..2148989) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" downshifts complement(2148437) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" misc_RNA complement(2148981..2149288) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" gene complement(2148981..2149288) /gene="fswB" /locus_tag="BSU_misc_RNA_78" S_feature complement(2148990..2149094) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(2149287..2149306) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2149303) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" promotor_-35 complement(2149320..2149326) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2149415..2149422 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2149433 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" promotor_-10 2149437..2149456 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2149486..2151063 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" gene 2149486..2151063 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" downshifts 2151045 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" CDS complement(2151106..2151873) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" gene complement(2151106..2151873) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" downshifts complement(2151121) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" S_feature 2151375..2151987 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(2151900..2151919) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2151913) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" promotor_-35 complement(2151934..2151937) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2151947 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" CDS complement(2151985..2153091) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" gene complement(2151985..2153091) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" downshifts complement(2152002) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" CDS complement(2153027..2153611) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" gene complement(2153027..2153611) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" promotor_-35 2153405..2153410 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2153421 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2153425..2153429 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2153562..2153567 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2153579 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" promotor_-10 2153583..2153601 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2153619 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2153660..2153679) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2153664..2153771 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(2153668) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" promotor_-35 complement(2153692..2153699) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2153727 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" S_feature complement(2153756..2153814) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(2153787) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" CDS complement(2153815..2155584) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" gene complement(2153815..2155584) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" downshifts complement(2153871) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" CDS complement(2155581..2156303) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" gene complement(2155581..2156303) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" S_feature complement(2156304..2156383) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(2156384..2157559) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " gene complement(2156384..2157559) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" CDS complement(2157579..2159207) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" gene complement(2157579..2159207) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" CDS complement(2159204..2159743) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" gene complement(2159204..2159743) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" S_feature complement(2159744..2159837) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(2159838..2160572) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" gene complement(2159838..2160572) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" promotor_-10 complement(2160581..2160600) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2160604) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" promotor_-35 complement(2160615..2160619) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2160664..2161200) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" gene complement(2160664..2161200) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" promotor_-10 complement(2160669..2160688) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2160673) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" promotor_-35 complement(2160703..2160710) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2161205..2161795) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" gene complement(2161205..2161795) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" CDS complement(2161783..2162931) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" gene complement(2161783..2162931) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" promotor_-10 complement(2162953..2162971) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2162960) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" promotor_-35 complement(2162986..2162991) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2163054..2163593) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" gene complement(2163054..2163593) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" downshifts complement(2163067) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2163602..2163619) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2163617) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" promotor_-35 complement(2163634..2163639) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2163648..2164241) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" gene complement(2163648..2164241) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" CDS complement(2164231..2164986) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" gene complement(2164231..2164986) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" promotor_-35 2164830..2164839 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2164852..2164871 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2164861 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2165032..2165051) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2165047) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" promotor_-35 complement(2165065..2165072) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2165212..2165219 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2165230..2165249 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2165235 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" CDS 2165267..2165791 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" gene 2165267..2165791 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" CDS complement(2165805..2166179) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" gene complement(2165805..2166179) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" downshifts complement(2165821) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" promotor_-10 complement(2166241..2166260) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2166253) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" promotor_-35 complement(2166272..2166279) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2166292..2166756) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" gene complement(2166292..2166756) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" promotor_-35 2166627..2166631 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2166645..2166649 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2166648 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2166789..2167985) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" gene complement(2166789..2167985) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" CDS complement(2168000..2168647) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" gene complement(2168000..2168647) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" CDS complement(2168658..2169743) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" gene complement(2168658..2169743) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" S_feature complement(2169744..2169872) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(2169873..2170017) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" gene complement(2169873..2170017) /gene="fswA" /locus_tag="BSU_misc_RNA_36" promotor_-10 complement(2170034..2170053) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2170044) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" promotor_-35 complement(2170068..2170075) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2170137..2170481) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" gene complement(2170137..2170481) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" downshifts complement(2170152) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2170513..2170531) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2170526) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" promotor_-35 2170540..2170545 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2170546..2170552) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2170560..2171482 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 2170560 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" promotor_-10 2170561..2170579 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2170567..2170582) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2170570) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" S_feature complement(2170572..2170638) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(2170595..2170604) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2170633..2170641) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2170638) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" promotor_-35 complement(2170655..2170663) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2170716..2171270) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" gene complement(2170716..2171270) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" downshifts complement(2170726) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(2171296..2171315) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2171314) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" S_feature complement(2171316..2171715) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(2171327..2171333) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2171537..2171773 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" gene 2171537..2171773 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" CDS complement(2171716..2171922) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" gene complement(2171716..2171922) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" misc_feature complement(2171955..2171974) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2171977) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" CDS complement(2172031..2172285) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" gene complement(2172031..2172285) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo promotor_-35 2172165..2172174 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2172176..2172565) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" gene complement(2172176..2172565) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo S_feature 2172188..2173259 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 2172188..2172207 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2172188 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" CDS complement(2172543..2172746) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" gene complement(2172543..2172746) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" CDS 2173155..2173271 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" gene 2173155..2173271 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo downshifts 2173222 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" promotor_-35 2173348..2173357 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2173370..2173389 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2173370 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" CDS 2173412..2173624 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" gene 2173412..2173624 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" downshifts 2173618 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" downshifts complement(2173760) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" CDS complement(2173760..2174191) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" gene complement(2173760..2174191) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" S_feature complement(2174192..2174278) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(2174261..2174280) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2174278) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" promotor_-35 complement(2174294..2174299) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2174328..2174337 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2174347..2174444 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 2174347 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" promotor_-10 2174350..2174365 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2174445..2175317 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" gene 2174445..2175317 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" downshifts 2175224 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" downshifts 2175290 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" CDS complement(2175347..2176666) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" gene complement(2175347..2176666) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" downshifts complement(2175367) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" S_feature complement(2176667..2176731) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(2176727..2176746) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2176731) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" promotor_-35 complement(2176761..2176768) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2176772..2178253) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /translation="MPDHKEEKIRVYRNPAKNEEYFKNRVGMGTSYDVGVRKLTILDK EIQLYYLNGLCDTAYIIHLMRELVAINNRKEDPDELVDIVENRLLNAQVEKVKTLDET TDQVLSGLVAVIVEGAGFAFIIDVRSYPGRNPEEPDTEKVVRGARDGFVENIVVNTAL LRRRIRDERLRVKMTKVGERSKTDLSICYIEDIADPDLVEIVEKEIASIDVDGLTMAD KTVEEFIVNQSYNPFPLVRYTERPDVAANHVLEGHVIIIVDTSPSVIITPTTLFHHVQ HAEEYRQAPSVGTFLRWVRFFGILASTLFLPIWFLFVLQPDLLPDNMKFIGLNKDTHI PIILQIFLADLGIEFLRMAAIHTPTALSTAMGLIAAVLIGQIAIEVGLFSPEVILYVS LAAIGTFTTPSYELSLANKMSRLVLMILVALFHIKGLVIGFTVLIIAMASIKSLQTPY LWPLIPFNGKALWQVLVRTAKPGAKVRPSIVHPKNRLRQPTNS*" gene complement(2176772..2178253) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" misc_feature complement(2177478..2177497) /Source="Nicolas_upshift_promotors" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2177482) /Source="Nicolas_upshifts" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2178204..2178815) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation germinant protein" /protein_id="YP_003097758.1" /db_xref="EnsemblGenomes-Gn:BSU23401" /db_xref="EnsemblGenomes-Tr:CAX52658" /db_xref="GOA:P40870" /db_xref="InterPro:IPR025914" /db_xref="UniProtKB/Swiss-Prot:P40870" /translation="MTTKRKVILVTDGDVYAAKTIEYAASKVGGRCISQSKGNPSTRS GAELVKLIASAPYDPVFVMFDDSGLQGEGPGEAALTYVATHPSIEVLGVIAVASKTHQ AEWTRVDVSIDRNGEITEYGVDKVGEREFDDHRMSGDTVYCLDKLDLPLIVGIGDIGK MGRKDDISKGSPITMKAVEFILERSGYHAGPQGRENSGLSESS*" gene complement(2178204..2178815) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" CDS complement(2178823..2179173) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" /experiment="publication(s) with functional evidences, PMID:17573930, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17573930, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germinant protein" /protein_id="YP_003097759.1" /db_xref="EnsemblGenomes-Gn:BSU23402" /db_xref="EnsemblGenomes-Tr:CAX52659" /db_xref="GOA:C0H450" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014204" /db_xref="UniProtKB/Swiss-Prot:C0H450" /translation="MDYLLAFVCGGAICIVGQLLLDIFKLTPAHVMTSFVVIGAILDG FGIYDKFIEFAGGGATVPIVSFGHSLLHGAMHQAHIHGFIGIGMGIFELTSAGISAAI LFAFIVAVIFKPKG*" gene complement(2178823..2179173) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" CDS complement(2179175..2180191) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 22328679, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 22328679, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AD (uptake of pyridine-2,6-dicarboxylic acid)" /protein_id="NP_390222.1" /db_xref="EnsemblGenomes-Gn:BSU23410" /db_xref="EnsemblGenomes-Tr:CAB14273" /db_xref="GOA:P40869" /db_xref="InterPro:IPR010894" /db_xref="InterPro:IPR016039" /db_xref="PDB:3LM6" /db_xref="SubtiList:BG10895" /db_xref="UniProtKB/Swiss-Prot:P40869" /translation="MKLTGKQTWVFEHPIFVNSAGTAAGPKEKDGPLGSLFDKTYDEM HCNQKSWEMAERQLMEDAVNVALQKNNLTKDDIDLLLAGDLLNQNVTANYVARHLKIP FLCMFGACSTSMETVAVASALVDGGFAKRALAATSSHNATAERQFRYPTEYGGQKPDT ATSTVTGSGAVVISQTPGDIQITSATVGKVSDLGITDPFDMGSAMAPAAADTIKQHFK DLNRTADDYDLILTGDLSGVGSPIVKDILKEDGYPVGTKHDDCGLLIYTPDQQVFAGG SGCACSAVVTYSHIFKQLREGKLNRVFVVATGALLSPTMIQQKETIPTIAHGVVFERA GGAS*" gene complement(2179175..2180191) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" promotor_-35 2179671..2179678 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2179692..2179711 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2179714 /Source="Nicolas_upshifts" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2180204..2180656) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 24666282, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 24666282, 26604257, 27105070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="mechanosensitive channel; stage V sporulation protein AC" /protein_id="NP_390223.1" /db_xref="EnsemblGenomes-Gn:BSU23420" /db_xref="EnsemblGenomes-Tr:CAB14274" /db_xref="GOA:P40868" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014203" /db_xref="SubtiList:BG10894" /db_xref="UniProtKB/Swiss-Prot:P40868" /translation="MTNIKENYKSKVKTYQPKPPYVWNCVKAFLVGGLICAIGQGLQN FYIHFFDFNEKTAGNPTAATLILISALLTGFGIYDRIGQFAGAGSAVPVTGFANSMAS AALEYKSEGLVLGVATNMFKLAGNVIVFGVVAAYIVGMIRFAFEKLMS*" gene complement(2180204..2180656) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" CDS complement(2180669..2181094) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AB" /protein_id="NP_390224.1" /db_xref="EnsemblGenomes-Gn:BSU23430" /db_xref="EnsemblGenomes-Tr:CAB14275" /db_xref="GOA:P40867" /db_xref="InterPro:IPR020144" /db_xref="SubtiList:BG10893" /db_xref="UniProtKB/Swiss-Prot:P40867" /translation="MIVSVLFIIFVGLGGGITVGAGFVAFLTVMGIIPRLMQLTKTMR FVQAYEAAVILGAVCGGWETLHMNHLYLTKWIAVPVGLLAGLFVGMLAAALTEVLNVL PILAKRIGLRSKIIILLMAIVIGKIAGSLFHWLYFIDHS*" gene complement(2180669..2181094) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" CDS complement(2181084..2181704) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:3114420, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3114420, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AA" /protein_id="NP_390225.2" /db_xref="EnsemblGenomes-Gn:BSU23440" /db_xref="EnsemblGenomes-Tr:CAB14276" /db_xref="GOA:P40866" /db_xref="InterPro:IPR021997" /db_xref="SubtiList:BG10892" /db_xref="UniProtKB/Swiss-Prot:P40866" /translation="MERRIFIRLRHRVLAHPGDIITVGDAAQIEGQLQLKKKLSAMPL YQVSEKDKNIVILDIIQVLRAIHLQDPTIDVQTVGGAETIVEIQYRKRNLSTVLFIGV WLLLFIGSCLAIMNFHEDVSMRDVHIALYEIITGERNDYPYLLQIPYSIGLGLGMIVF FNHIFKKRLNEEPSPLEVEMFNYQLDLDQYVAMHENQETIKDLHDR*" gene complement(2181084..2181704) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" promotor_-10 complement(2181735..2181746) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2181745) /Source="Nicolas_upshifts" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" promotor_-35 complement(2181760..2181766) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2181829..2182596) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma factor(sigma-F)" /protein_id="NP_390226.1" /db_xref="EnsemblGenomes-Gn:BSU23450" /db_xref="EnsemblGenomes-Tr:CAB14277" /db_xref="GOA:P07860" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014236" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10298" /db_xref="UniProtKB/Swiss-Prot:P07860" /translation="MDVEVKKNGKNAQLKDHEVKELIKQSQNGDQQARDLLIEKNMRL VWSVVQRFLNRGYEPDDLFQIGCIGLLKSVDKFDLTYDVRFSTYAVPMIIGEIQRFIR DDGTVKVSRSLKELGNKIRRAKDELSKTLGRVPTVQEIADHLEIEAEDVVLAQEAVRA PSSIHETVYENDGDPITLLDQIADNSEEKWFDKIALKEAISDLEEREKLIVYLRYYKD QTQSEVAERLGISQVQVSRLEKKILKQIKVQMDHTDG*" gene complement(2181829..2182596) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" downshifts complement(2181859) /Source="Nicolas_upshifts" /id="D1225" /incds=0 /nref=89 /ntot=197 /MaxReadThrough="1.81932" /MaxDrop="7.16571" /score="21.6169221" /energy="-13.5" /TU="NA" /idTUdmin="U1834" /TUdmin=1 /isTUend="TRUE" CDS complement(2182608..2183048) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" /EC_number="2.7.11.-" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15023063, 15187183, 15819616, 16166546, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023063, 15187183, 15819616, 16166546, 16824103, 22115775; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="anti-sigma factor (antagonist of sigma(F)) and serine kinase" /protein_id="NP_390227.1" /db_xref="EnsemblGenomes-Gn:BSU23460" /db_xref="EnsemblGenomes-Tr:CAB14278" /db_xref="GOA:P10728" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010194" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10297" /db_xref="UniProtKB/Swiss-Prot:P10728" /translation="MKNEMHLEFSALSQNESFARVTVASFIAQLDPTMDELTEIKTVV SEAVTNAIIHGYEENCEGKVYISVTLEDHVVYMTIRDEGLGITDLEEARQPLFTTKPE LERSGMGFTIMENFMDDVSIDSSPEMGTTIRLTKHLSKSKALCN*" gene complement(2182608..2183048) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" CDS complement(2183045..2183398) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11173484, 15819616, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11173484, 15819616, 16824103, 22115775; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of SpoIIAB)" /protein_id="NP_390228.1" /db_xref="EnsemblGenomes-Gn:BSU23470" /db_xref="EnsemblGenomes-Tr:CAB14279" /db_xref="GOA:P10727" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR014237" /db_xref="InterPro:IPR036513" /db_xref="PDB:1AUZ" /db_xref="PDB:1BUZ" /db_xref="SubtiList:BG10296" /db_xref="UniProtKB/Swiss-Prot:P10727" /translation="MSLGIDMNVKESVLCIRLTGELDHHTAETLKQKVTQSLEKDDIR HIVLNLEDLSFMDSSGLGVILGRYKQIKQIGGEMVVCAISPAVKRLFDMSGLFKIIRF EQSEQQALLTLGVAS*" gene complement(2183045..2183398) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" promotor_-10 complement(2183423..2183441) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2183434) /Source="Nicolas_upshifts" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" S_feature complement(2183436..2183493) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" promotor_-35 complement(2183453..2183461) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2183494..2184663) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" gene complement(2183494..2184663) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" promotor_-10 complement(2184692..2184703) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2184707) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" promotor_-35 complement(2184717..2184723) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2184809) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" CDS complement(2184818..2185633) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" gene complement(2184818..2185633) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" CDS complement(2185646..2186830) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" gene complement(2185646..2186830) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" promotor_-10 complement(2186879..2186898) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2186897) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" S_feature complement(2186899..2186990) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(2186914..2186921) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2186991..2187881) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" gene complement(2186991..2187881) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" CDS complement(2187889..2188116) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" gene complement(2187889..2188116) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" promotor_-10 complement(2188019..2188038) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2188030) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" promotor_-35 complement(2188052..2188059) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2188109) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" promotor_-10 complement(2188118..2188136) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2188146..2188164) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2188152..2188158) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2188159) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" promotor_-35 complement(2188181..2188186) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2188241) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" CDS complement(2188241..2188690) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" gene complement(2188241..2188690) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" promotor_-10 complement(2188714..2188733) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(2188724) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" S_feature complement(2188726..2188802) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(2188749..2188753) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(2188803..2189447) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" gene complement(2188803..2189447) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" promotor_-10 complement(2189478..2189496) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(2189495) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" promotor_-35 complement(2189511..2189516) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(2189548..2189763) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" gene complement(2189548..2189763) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" downshifts complement(2189628) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" CDS complement(2189863..2191182) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" gene complement(2189863..2191182) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" downshifts complement(2189870) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" CDS complement(2191200..2192606) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" gene complement(2191200..2192606) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" promotor_-10 complement(2192654..2192673) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2192663) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" S_feature complement(2192665..2192746) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(2192688..2192695) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2192747..2194174) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" gene complement(2192747..2194174) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" CDS complement(2194219..2195208) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" gene complement(2194219..2195208) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" S_feature complement(2195209..2195288) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(2195270..2195289) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2195288) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" S_feature complement(2195290..2195610) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(2195304..2195311) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2195329..2195336 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2195349..2195368 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2195351 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" CDS 2195390..2195740 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" gene 2195390..2195740 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" S_feature complement(2195612..2195748) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(2195655) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" CDS complement(2195749..2196912) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" gene complement(2195749..2196912) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" CDS complement(2196909..2197466) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" gene complement(2196909..2197466) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" promotor_no_box complement(2197396..2197496) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2197436) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" promotor_-35 2197480..2197485 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2197501..2197519 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2197503..2197517) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 2197507 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" S_feature 2197514..2197688 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(2197519..2197522) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(2197522) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" CDS 2197541..2197663 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" gene 2197541..2197663 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" promotor_-35 2197664..2197671 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2197685..2197704 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2197690 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" CDS 2197726..2198646 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" gene 2197726..2198646 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" downshifts 2198635 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" CDS complement(2198678..2198902) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" gene complement(2198678..2198902) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" downshifts complement(2198735) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2198925..2198944) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2198932) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" promotor_-35 complement(2198959..2198966) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2198981..2198988 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2199003..2199022 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2199010 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" CDS 2199064..2199981 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" gene 2199064..2199981 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" downshifts 2199956 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" CDS complement(2200021..2200260) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" gene complement(2200021..2200260) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" downshifts complement(2200032) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" CDS complement(2200273..2200596) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" gene complement(2200273..2200596) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" promotor_-10 complement(2200339..2200358) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2200340) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" promotor_-35 complement(2200372..2200379) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2200593..2201624) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" gene complement(2200593..2201624) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" promotor_-10 complement(2200620..2200639) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2200627) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" promotor_-35 complement(2200650..2200657) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2201617..2201961) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" gene complement(2201617..2201961) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" CDS complement(2201971..2202441) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" gene complement(2201971..2202441) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" S_feature complement(2202442..2202518) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 2202442 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" promotor_-10 complement(2202493..2202512) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2202518) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" S_feature complement(2202520..2202626) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(2202527..2202534) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2202627..2202965) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" gene complement(2202627..2202965) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" CDS complement(2202962..2204200) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" gene complement(2202962..2204200) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" misc_feature 2203124..2203125 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2203135 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2203190 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2204225..2204243) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(2204234) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" promotor_-35 complement(2204260..2204265) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 2204305..2204308 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2204323..2204342 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2204332 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" CDS 2204366..2204572 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" gene 2204366..2204572 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" promotor_-35 2205055..2205058 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2205073..2205092 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2205089 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" CDS 2205121..2206353 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" gene 2205121..2206353 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" CDS 2206200..2206562 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" gene 2206200..2206562 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" S_feature complement(2206379..2206558) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(2206412) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" CDS complement(2206559..2206945) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" gene complement(2206559..2206945) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" CDS complement(2206949..2207908) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" gene complement(2206949..2207908) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" S_feature complement(2207909..2207979) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(2207980..2209326) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" gene complement(2207980..2209326) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" S_feature complement(2209327..2209401) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(2209402..2210181) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" gene complement(2209402..2210181) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" CDS complement(2210187..2211146) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" gene complement(2210187..2211146) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" promotor_-10 complement(2211168..2211187) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2211187) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" promotor_-35 complement(2211202..2211209) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2211243..2211250 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2211264..2211550 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 2211264 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" promotor_-10 2211266..2211285 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2211280..2211525 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" gene 2211280..2211525 /gene="pswI" /locus_tag="BSU_misc_RNA_91" CDS 2211551..2212387 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" gene 2211551..2212387 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" downshifts 2212385 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" CDS complement(2212428..2214071) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" gene complement(2212428..2214071) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" downshifts complement(2212440) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" promotor_-35 2214089..2214095 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2214102 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2214109..2214120 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2214127..2214146) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2214132) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" promotor_-35 2214178..2214185 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2214199..2214218 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2214201 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" CDS 2214243..2215259 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" gene 2214243..2215259 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" downshifts 2215246 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" promotor_-35 2215308..2215317 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2215330..2215345 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2215334 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" CDS 2215369..2216130 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" gene 2215369..2216130 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" downshifts 2216038 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" downshifts 2216126 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" S_feature complement(2216158..2216358) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(2216174..2216299) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" gene complement(2216174..2216299) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo downshifts complement(2216201) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" CDS complement(2216292..2216324) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" gene complement(2216292..2216324) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo promotor_-10 complement(2216352..2216371) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2216358) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" promotor_-35 complement(2216384..2216391) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2216406..2217329) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" gene complement(2216406..2217329) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" promotor_-10 complement(2217355..2217374) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2217368) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" promotor_-35 complement(2217388..2217393) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2217467..2217474 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2217488..2217507 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2217490..2217555 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 2217490 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" CDS 2217556..2219025 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" gene 2217556..2219025 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" downshifts 2219008 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" downshifts 2219076 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" CDS complement(2219150..2220559) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" gene complement(2219150..2220559) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" downshifts complement(2219167) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" downshifts complement(2219240) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" misc_feature complement(2220623..2220641) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2220625) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" CDS complement(2220669..2221913) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" gene complement(2220669..2221913) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" S_feature complement(2221914..2222188) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 2221934..2221941 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2221955..2221974 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2221955 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" CDS 2221986..2222273 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" gene 2221986..2222273 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" promotor_-10 complement(2222170..2222189) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(2222190) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" promotor_-35 complement(2222205..2222208) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 2222304..2223131 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " gene 2222304..2223131 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" downshifts 2222948 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" downshifts 2223124 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" S_feature complement(2223136..2224056) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(2223179) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" promotor_-35 2223249..2223255 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2223269..2223287 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2223278 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" CDS 2223311..2224039 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" gene 2223311..2224039 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" CDS complement(2224080..2225195) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" gene complement(2224080..2225195) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" downshifts complement(2224101) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" CDS complement(2225213..2226736) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " gene complement(2225213..2226736) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" promotor_-10 complement(2226319..2226338) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2226341) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" promotor_-35 complement(2226353..2226357) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2226729..2227151) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" gene complement(2226729..2227151) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" promotor_-35 2227180..2227187 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2227201..2227220 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2227215..2227368 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 2227215 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" downshifts 2227325 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" CDS complement(2227353..2227883) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" gene complement(2227353..2227883) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" S_feature 2227370..2228005 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(2227900..2227911) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2227907) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" promotor_-35 complement(2227926..2227932) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2227935..2228903) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" gene complement(2227935..2228903) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" downshifts complement(2227951) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" CDS complement(2228974..2229696) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" gene complement(2228974..2229696) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" downshifts complement(2228985) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" CDS complement(2229689..2230348) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" gene complement(2229689..2230348) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" S_feature complement(2230349..2230428) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(2230429..2231196) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" gene complement(2230429..2231196) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" promotor_-10 complement(2231246..2231265) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2231261) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" promotor_-35 complement(2231280..2231287) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2231464..2231901) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" gene complement(2231464..2231901) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" downshifts complement(2231473) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" promotor_-10 complement(2231925..2231944) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(2231946) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" promotor_-35 complement(2231959..2231966) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 2231999..2232005 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2232018 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" promotor_-10 2232020..2232038 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2232062..2232955 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" gene 2232062..2232955 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" promotor_-35 2232988..2232995 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2233011..2233030 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2233019 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" CDS 2233056..2234225 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" gene 2233056..2234225 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" downshifts 2234208 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" CDS 2234298..2235134 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" gene 2234298..2235134 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" downshifts 2235132 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" downshifts complement(2235196) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" CDS complement(2235196..2236470) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" gene complement(2235196..2236470) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" CDS complement(2236493..2237476) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" gene complement(2236493..2237476) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" CDS complement(2237490..2238482) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" gene complement(2237490..2238482) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" CDS complement(2238504..2239928) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" gene complement(2238504..2239928) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" CDS complement(2239949..2241040) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" gene complement(2239949..2241040) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" CDS complement(2241059..2242153) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" gene complement(2241059..2242153) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" CDS complement(2242165..2243064) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" gene complement(2242165..2243064) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" misc_feature complement(2243100..2243119) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2243105) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" S_feature complement(2243107..2243188) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(2243189..2245267) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" gene complement(2243189..2245267) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" promotor_-10 complement(2245327..2245346) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2245344) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" promotor_-35 2245354..2245361 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2245363..2245366) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2245375..2245394 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2245382 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" CDS 2245420..2245656 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" gene 2245420..2245656 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" downshifts 2245647 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" CDS complement(2245698..2246603) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" gene complement(2245698..2246603) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" downshifts complement(2245701) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" CDS complement(2246621..2248039) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" gene complement(2246621..2248039) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" misc_feature complement(2246916..2246935) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2246933) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2248054..2249172) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" gene complement(2248054..2249172) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" CDS complement(2249206..2250345) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" gene complement(2249206..2250345) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" CDS complement(2250373..2251236) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" gene complement(2250373..2251236) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" CDS complement(2251261..2252442) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" gene complement(2251261..2252442) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" downshifts complement(2252022) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" misc_feature complement(2252129..2252135) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2252132) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_no_box complement(2252356..2252456) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2252396) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2252489..2252507) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2252507) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" promotor_-35 complement(2252523..2252528) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2252569..2253300) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" gene complement(2252569..2253300) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" downshifts complement(2252576) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" promotor_-10 complement(2253323..2253342) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2253334) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" promotor_-35 complement(2253357..2253360) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2253379..2253999) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" gene complement(2253379..2253999) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" CDS complement(2254014..2254307) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" gene complement(2254014..2254307) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" promotor_-10 complement(2254327..2254346) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2254333) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" promotor_-35 complement(2254361..2254368) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2254563..2254570 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2254584..2254603 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2254601..2254806 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 2254601 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" CDS 2254615..2254767 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" gene 2254615..2254767 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" promotor_-35 2254775..2254782 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2254797..2254816 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2254808 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" CDS 2254840..2255958 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" gene 2254840..2255958 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" downshifts 2255943 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" S_feature complement(2255985..2256155) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(2256028) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2256139..2256154) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2256155) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" S_feature complement(2256157..2256285) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(2256166..2256175) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2256284..2256303) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2256307) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" promotor_-35 complement(2256317..2256325) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2256417) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" CDS complement(2256423..2257226) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" gene complement(2256423..2257226) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" promotor_-10 complement(2257269..2257287) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2257275) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" S_feature complement(2257277..2257429) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(2257298..2257306) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2257425..2257444) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2257437) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" promotor_-35 complement(2257456..2257463) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2257502..2258782) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="regulatory membrane-associated serine protease" /protein_id="NP_390303.2" /db_xref="EnsemblGenomes-Gn:BSU24230" /db_xref="EnsemblGenomes-Tr:CAB14354" /db_xref="GOA:P17896" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008763" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR014219" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG10311" /db_xref="UniProtKB/Swiss-Prot:P17896" /translation="MPDNIRKAVGLILLVSLLSVGLCKPLKEYLLIPTQMRVFETQTQ AIETSLSVNAQTSESSEAFTVKKDPHEIKVTGKKSGESELVYDLAGFPIKKTKVHVLP DLKVIPGGQSIGVKLHSVGVLVVGFHQINTSEGKKSPGETAGIEAGDIIIEMNGQKIE KMNDVAPFIQKAGKTGESLDLLIKRDKQKIKTKLIPEKDEGEGKYRIGLYIRDSAAGI GTMTFYEPKTKKYGALGHVISDMDTKKPIVVENGEIVKSTVTSIEKGTGGNPGEKLAR FSSERKTIGDINRNSPFGIFGTLHQPIQNNISDQALPVAFSTEVKKGPAEILTVIDDD KVEKFDIEIVSTTPQKFPATKGMVLKITDPRLLKETGGIVQGMSGSPIIQNGKVIGAV THVFVNDPTSGYGVHIEWMLSEAGIDIYGKEKAS*" gene complement(2257502..2258782) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" downshifts complement(2257517) /Source="Nicolas_upshifts" /id="D1266" /incds=0 /nref=34 /ntot=51 /MaxReadThrough="1.04939" /MaxDrop="7.80695" /score="49.1812184" /energy="-12.5" /TU="NA" /idTUdmin="U1893" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2258843..2258854) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2258857) /Source="Nicolas_upshifts" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" promotor_-35 complement(2258869..2258875) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2258957..2260687) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" gene complement(2258957..2260687) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" downshifts complement(2258972) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" CDS complement(2260724..2261173) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" gene complement(2260724..2261173) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" S_feature complement(2261174..2261259) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(2261271..2262116) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" gene complement(2261271..2262116) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" downshifts complement(2261304) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" CDS complement(2262113..2264014) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" gene complement(2262113..2264014) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" promotor_-35 2263222..2263228 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2263243..2263254 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2263251 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2264015..2264143) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(2264138..2264157) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2264143) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" promotor_-35 complement(2264172..2264178) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2264189..2265079) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" gene complement(2264189..2265079) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" CDS complement(2265069..2265323) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" gene complement(2265069..2265323) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" CDS complement(2265320..2266666) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" gene complement(2265320..2266666) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" S_feature complement(2266667..2266803) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(2266804..2267655) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" gene complement(2266804..2267655) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" CDS complement(2267667..2268062) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" gene complement(2267667..2268062) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" misc_feature complement(2268105..2268124) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2268124) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" S_feature complement(2268126..2268288) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(2268326..2268733) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" gene complement(2268326..2268733) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" downshifts complement(2268333) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" CDS complement(2268754..2270106) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" gene complement(2268754..2270106) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" promotor_-10 complement(2269635..2269654) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(2269642) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" promotor_-35 complement(2269669..2269675) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(2270118..2270597) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " gene complement(2270118..2270597) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" promotor_-10 complement(2270656..2270675) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2270667) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" promotor_-35 complement(2270689..2270696) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2270753..2271409) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" gene complement(2270753..2271409) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" downshifts complement(2270760) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" CDS complement(2271410..2272099) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" gene complement(2271410..2272099) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" CDS complement(2272092..2272712) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" gene complement(2272092..2272712) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" promotor_-10 complement(2272418..2272436) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2272436) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" promotor_-35 complement(2272452..2272457) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2272726..2273925) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" gene complement(2272726..2273925) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" CDS complement(2273944..2274345) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" gene complement(2273944..2274345) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" CDS complement(2274352..2274558) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" gene complement(2274352..2274558) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" CDS complement(2274581..2275096) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" gene complement(2274581..2275096) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" CDS complement(2275090..2276013) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" gene complement(2275090..2276013) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" S_feature complement(2276014..2276088) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(2276089..2276370) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" gene complement(2276089..2276370) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" promotor_-10 complement(2276390..2276408) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(2276413) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" promotor_-35 complement(2276424..2276429) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(2276515..2277072) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" gene complement(2276515..2277072) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" downshifts complement(2276527) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" CDS complement(2277097..2278158) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" gene complement(2277097..2278158) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" CDS complement(2278155..2278601) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" gene complement(2278155..2278601) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" promotor_-10 complement(2278650..2278669) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2278666) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" promotor_-35 complement(2278682..2278689) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2278688..2279224) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" gene complement(2278688..2279224) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" promotor_-10 complement(2279237..2279248) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(2279246) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" promotor_-35 complement(2279262..2279268) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 2279294..2279300 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2279313 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" promotor_-10 2279315..2279333 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2279370..2279373 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2279388..2279407 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2279399 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" CDS 2279451..2280407 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" gene 2279451..2280407 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" CDS 2280447..2280842 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" gene 2280447..2280842 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" promotor_no_box 2280725..2280825 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2280785 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2280828 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" CDS complement(2280839..2281714) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" gene complement(2280839..2281714) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" promotor_-10 complement(2281741..2281759) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2281758) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" promotor_-35 complement(2281775..2281780) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2281840..2282268) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" gene complement(2281840..2282268) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" downshifts complement(2281867) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" promotor_-10 complement(2282303..2282322) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2282311) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" promotor_-35 complement(2282338..2282342) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2282368..2283204) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" gene complement(2282368..2283204) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" promotor_-10 complement(2283228..2283247) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2283239) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" S_feature complement(2283241..2283785) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(2283261..2283268) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2283285..2283290 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2283304..2283323 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2283304 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" S_feature 2283315..2283394 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 2283395..2283775 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" gene 2283395..2283775 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" downshifts 2283711 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" downshifts 2283755 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" CDS complement(2283810..2285276) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" gene complement(2283810..2285276) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" downshifts complement(2283830) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" CDS complement(2285269..2286615) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" gene complement(2285269..2286615) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" CDS complement(2286645..2287733) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" gene complement(2286645..2287733) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" misc_RNA complement(2287807..2288006) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" gene complement(2287807..2288006) /gene="swgA" /locus_tag="BSU_misc_RNA_37" downshifts complement(2287857) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" S_feature complement(2288007..2288077) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 2288010..2288015 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2288031..2288049 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2288035 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" S_feature 2288045..2288174 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(2288063..2288082) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(2288077) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" promotor_-35 complement(2288096..2288103) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 2288175..2289848 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" gene 2288175..2289848 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" CDS 2289869..2290663 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" gene 2289869..2290663 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" misc_feature 2290199..2290200 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2290205 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" promotor_-35 2290687..2290690 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2290706..2290725 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2290707..2290845 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 2290707 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" CDS 2290846..2291019 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" gene 2290846..2291019 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" promotor_-35 2291004..2291008 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2291021..2291040 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2291021 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" CDS 2291053..2291388 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" gene 2291053..2291388 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" downshifts 2291365 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" downshifts 2291455 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" CDS complement(2291481..2292266) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="major biofilm matrix component" /protein_id="NP_390342.1" /db_xref="EnsemblGenomes-Gn:BSU24620" /db_xref="EnsemblGenomes-Tr:CAB14393" /db_xref="GOA:P54507" /db_xref="InterPro:IPR022121" /db_xref="InterPro:IPR023833" /db_xref="SubtiList:BG11697" /db_xref="UniProtKB/Swiss-Prot:P54507" /translation="MGMKKKLSLGVASAALGLALVGGGTWAAFNDIKSKDATFASGTL DLSAKENSASVNLSNLKPGDKLTKDFQFENNGSLAIKEVLMALNYGDFKANGGSNTSP EDFLSQFEVTLLTVGKEGGNGYPKNIILDDANLKDLYLMSAKNDAAAAEKIKKQIDPK FLNASGKVNVATIDGKTAPEYDGVPKTPTDFDQVQMEIQFKDDKTKDEKGLMVQNKYQ GNSIKLQFSFEATQWNGLTIKKDHTDKDGYVKENEKAHSEDKN*" gene complement(2291481..2292266) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" downshifts complement(2291487) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" misc_feature complement(2292319..2292336) /Source="Nicolas_upshift_promotors" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2292323) /Source="Nicolas_upshifts" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" CDS complement(2292330..2292902) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390343.1" /db_xref="EnsemblGenomes-Gn:BSU24630" /db_xref="EnsemblGenomes-Tr:CAB14394" /db_xref="GOA:P54506" /db_xref="InterPro:IPR001733" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11696" /db_xref="UniProtKB/Swiss-Prot:P54506" /translation="MKLISNILYVIIFTLIIVLTLVVISTRSSGGEPAVFGYTLKSVL SGSMEPEFNTGSLILVKEITDVKELQKGDVITFMQDANTAVTHRIVDITKQGDHLLFK TKGDNNAAADSAPVSDENVRAQYTGFQLPYAGYMLHFASQPIGTAVLLIVPGVMLLVY AFVTISSAIREIERKTKALETDTKDSTMST*" gene complement(2292330..2292902) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" CDS complement(2292886..2293647) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein for biofilm formation" /protein_id="NP_390344.1" /db_xref="EnsemblGenomes-Gn:BSU24640" /db_xref="EnsemblGenomes-Tr:CAB14395" /db_xref="GOA:P40949" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023833" /db_xref="InterPro:IPR023848" /db_xref="SubtiList:BG11076" /db_xref="UniProtKB/Swiss-Prot:P40949" /translation="MFRLFHNQQKAKTKLKVLLIFQLSVIFSLTAAICLQFSDDTSAA FHDIETFDVSLQTCKDFQHTDKNCHYDKRWDQSDLHISDQTDTKGTVCSPFALFAVLE NTGEKLKKSKWKWELHKLENARKPLKDGNVIEKGFVSNQIGDSLYKIETKKKMKPGIY AFKVYKPAGYPANGSTFEWSEPMRLAKCDEKPTVPKKETKSDVKKENETTQKDIPEKT MKEETSQEAVTKEKETQSDQKESGEEDEKSNEADQ*" gene complement(2292886..2293647) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" promotor_-10 complement(2293707..2293726) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-10" upshifts complement(2293725) /Source="Nicolas_upshifts" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" promotor_-35 complement(2293740..2293747) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-35" promotor_-35 2293869..2293875 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2293876 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" promotor_-10 2293889..2293900 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2293919..2294245 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" gene 2293919..2294245 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" S_feature complement(2294062..2294286) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(2294105) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" downshifts 2294227 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" CDS complement(2294287..2294466) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" gene complement(2294287..2294466) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" promotor_-10 complement(2294485..2294503) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2294500) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" promotor_-35 complement(2294518..2294524) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2294537..2294911) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" gene complement(2294537..2294911) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" CDS complement(2294912..2295295) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" gene complement(2294912..2295295) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" CDS complement(2295321..2295668) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" gene complement(2295321..2295668) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" CDS complement(2295652..2296083) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" gene complement(2295652..2296083) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" CDS complement(2296073..2296369) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" gene complement(2296073..2296369) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" CDS complement(2296383..2297354) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" gene complement(2296383..2297354) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" CDS complement(2297407..2298477) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" gene complement(2297407..2298477) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" promotor_-10 complement(2298495..2298514) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2298511) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" promotor_-35 complement(2298528..2298535) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2298660..2298888) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2298701) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" CDS complement(2298889..2299842) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" gene complement(2298889..2299842) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" promotor_-10 complement(2299866..2299885) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2299887) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" promotor_-35 complement(2299899..2299905) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2299925..2299931 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2299946..2299964 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2299964 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" CDS 2299985..2301313 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" gene 2299985..2301313 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" S_feature 2301314..2302288 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2301366..2302202) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" gene complement(2301366..2302202) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" S_feature complement(2302203..2302387) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2302289..2302359 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" gene 2302289..2302359 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" CDS complement(2302426..2302806) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" gene complement(2302426..2302806) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" downshifts complement(2302432) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" promotor_-10 complement(2302835..2302853) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2302854) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" promotor_-35 complement(2302868..2302874) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2302893..2302898 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2302914..2302932 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2302923 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" promotor_-35 2302973..2302980 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2302995 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" promotor_-10 2302996..2303015 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2303038..2303283 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" gene 2303038..2303283 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" downshifts 2303180 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" downshifts 2303269 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" S_feature 2303314..2304069 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2303323..2303958) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" gene complement(2303323..2303958) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" downshifts complement(2303348) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" promotor_-10 complement(2303980..2303999) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2303997) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" promotor_-35 complement(2304013..2304020) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2304037..2304044 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2304059..2304078 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2304071 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" upshifts complement(2304091) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2304093..2304107) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2304115..2304119) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2304115..2304288 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" gene 2304115..2304288 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" downshifts 2304276 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" CDS complement(2304320..2304634) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" gene complement(2304320..2304634) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" S_feature 2304321..2305388 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2304334) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" CDS complement(2304637..2305698) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" gene complement(2304637..2305698) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" CDS complement(2305760..2306890) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" gene complement(2305760..2306890) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" promotor_-10 complement(2306898..2306916) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2306930) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" promotor_-35 complement(2306932..2306937) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2306973..2308889) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" gene complement(2306973..2308889) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" downshifts complement(2307000) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" promotor_-35 2308005..2308011 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2308024..2309053 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2308024 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" promotor_-10 2308027..2308045 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2308890..2308956) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2308950..2308969) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2308956) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" promotor_-35 complement(2308984..2308991) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2309006..2309971) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" gene complement(2309006..2309971) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" CDS complement(2309982..2310197) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" gene complement(2309982..2310197) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" S_feature complement(2310198..2310306) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2310307..2311830) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " gene complement(2310307..2311830) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" promotor_-10 complement(2311848..2311867) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2311861) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" promotor_-35 complement(2311882..2311889) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2311920..2312093) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" gene complement(2311920..2312093) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" downshifts complement(2311947) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2312109..2312120) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2312121) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" promotor_-35 complement(2312134..2312140) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2312160..2312723) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" gene complement(2312160..2312723) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" S_feature complement(2312724..2312807) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2312808..2312957) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" gene complement(2312808..2312957) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" downshifts complement(2312854) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" promotor_-10 complement(2312994..2313013) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2313004) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" promotor_-35 complement(2313029..2313032) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2313041..2314120) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" gene complement(2313041..2314120) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" CDS complement(2314117..2314587) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" gene complement(2314117..2314587) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" promotor_-35 2314532..2314540 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2314554..2314562 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2314555..2314728 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2314556 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" promotor_-10 complement(2314623..2314642) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2314635) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" promotor_-35 complement(2314654..2314661) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2314700..2314704 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2314720..2314739 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2314730 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" CDS 2314767..2315120 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" gene 2314767..2315120 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" CDS 2315117..2315581 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" gene 2315117..2315581 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" downshifts 2315567 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" CDS complement(2315610..2316392) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" gene complement(2315610..2316392) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" downshifts complement(2315621) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" CDS complement(2316403..2317212) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" gene complement(2316403..2317212) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" CDS complement(2317233..2318117) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" gene complement(2317233..2318117) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" CDS complement(2318117..2319046) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" gene complement(2318117..2319046) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" CDS complement(2319115..2320017) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" gene complement(2319115..2320017) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" upshifts complement(2320072) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" promotor_-10 complement(2320080..2320096) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2320107..2320109) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2320171..2322321) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" gene complement(2320171..2322321) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" downshifts complement(2320181) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" promotor_-10 complement(2320915..2320933) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2320923) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2320949..2320955) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2321610..2321629) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2321627) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2321643..2321652) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2322371..2322390) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2322376) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" promotor_-35 complement(2322406..2322410) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2322435..2323727) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" gene complement(2322435..2323727) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" promotor_-10 complement(2323750..2323761) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2323761) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" promotor_-35 complement(2323775..2323781) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2323834..2324442) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" gene complement(2323834..2324442) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" downshifts complement(2323849) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2324494..2324513) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2324505) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" S_feature complement(2324507..2324575) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2324528..2324535) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2324566..2324584) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2324575) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" promotor_-35 complement(2324599..2324605) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2324621..2325103) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" gene complement(2324621..2325103) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" S_feature complement(2325104..2325396) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2325146..2325152 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2325167..2325186 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2325180 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" CDS 2325213..2325980 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" gene 2325213..2325980 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" promotor_-10 complement(2325394..2325412) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2325396) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" S_feature complement(2325398..2326334) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2325426..2325432) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2325981..2326411 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2326368 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" downshifts complement(2326379) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" CDS complement(2326396..2326824) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" gene complement(2326396..2326824) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" promotor_-35 2326820..2326824 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2326834..2326848 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2326843 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" promotor_-10 complement(2326847..2326866) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2326870) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" promotor_-35 complement(2326881..2326888) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2327039..2327044 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2327060..2327078 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2327072 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" CDS 2327101..2327400 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" gene 2327101..2327400 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" promotor_-35 2327413..2327420 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2327435..2327454 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2327446..2327522 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2327446 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" CDS 2327523..2328656 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" gene 2327523..2328656 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" downshifts 2328637 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" CDS complement(2328682..2329071) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" gene complement(2328682..2329071) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" downshifts complement(2328708) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" promotor_-10 complement(2329102..2329113) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2329106) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" promotor_-35 complement(2329127..2329133) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2329146..2329153 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2329164..2329183 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2329165 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" CDS 2329204..2329785 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" gene 2329204..2329785 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" downshifts 2329783 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" S_feature 2329828..2330436 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2329828..2330265) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" gene complement(2329828..2330265) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" downshifts complement(2329832) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" S_feature complement(2330266..2330360) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2330356..2330375) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2330360) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" promotor_-35 complement(2330390..2330397) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2330403..2331284) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" gene complement(2330403..2331284) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" promotor_-35 2331280..2331285 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2331301..2331319 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2331317 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" misc_feature complement(2331322..2331341) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2331328) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" S_feature complement(2331330..2331657) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2331346..2331355 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2331362 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" promotor_-10 2331368..2331387 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2331400..2331654 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" gene 2331400..2331654 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" downshifts 2331641 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" CDS complement(2331681..2332574) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" gene complement(2331681..2332574) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" S_feature 2331686..2332487 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2331702) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" CDS complement(2332584..2333900) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" gene complement(2332584..2333900) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" promotor_-10 complement(2333936..2333955) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2333947) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" promotor_-35 complement(2333971..2333975) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2334004..2334013 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2334025 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" promotor_-10 2334027..2334046 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2334069..2334812 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" gene 2334069..2334812 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" downshifts 2334794 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" promotor_-35 2334816..2334823 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2334837..2334856 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2334839..2334934 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2334839 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" CDS 2334935..2335879 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" gene 2334935..2335879 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" downshifts 2335850 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" CDS complement(2335902..2337023) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" gene complement(2335902..2337023) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" downshifts complement(2335927) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" CDS complement(2337016..2337666) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" gene complement(2337016..2337666) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" S_feature complement(2337667..2337775) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2337763..2337782) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2337775) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" S_feature complement(2337777..2337890) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2337798..2337802) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2337923..2338285) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" gene complement(2337923..2338285) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" downshifts complement(2337935) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" promotor_-35 2338281..2338285 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2338293..2338307 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2338314 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2338322..2338341) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2338324) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" S_feature complement(2338326..2338447) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2338353..2338360) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2338427 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2338436..2338455) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2338444..2338463 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2338447) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" S_feature complement(2338449..2338588) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2338450..2338554 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2338450 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" promotor_-35 complement(2338469..2338475) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2338518..2338525 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2338539..2338558 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2338556..2340705 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2338556 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" CDS complement(2338614..2339729) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" gene complement(2338614..2339729) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" downshifts complement(2338633) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" S_feature complement(2339730..2339927) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2339928..2341739) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" gene complement(2339928..2341739) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" promotor_-35 2341334..2341340 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2341350 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" promotor_-10 2341352..2341371 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2341379..2341675 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" gene 2341379..2341675 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" CDS complement(2341773..2342267) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" gene complement(2341773..2342267) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" promotor_-10 complement(2342240..2342258) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2342251) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" S_feature complement(2342268..2342381) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2342270..2342278) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2342276..2342281 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2342297..2342315 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2342312 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2342366..2342384) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2342381) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" S_feature complement(2342383..2342460) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2342400..2342405) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2342426..2342445) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2342460) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" promotor_-35 complement(2342461..2342464) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2342521..2343333) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" gene complement(2342521..2343333) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" CDS complement(2343359..2343997) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" gene complement(2343359..2343997) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" S_feature complement(2343998..2344129) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2344123..2344142) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2344130..2346169) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" gene complement(2344130..2346169) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" upshifts complement(2344132) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" promotor_-35 complement(2344157..2344164) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2344176) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" downshifts complement(2344242) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" CDS complement(2346162..2347049) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" gene complement(2346162..2347049) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" misc_RNA complement(2347132..2347306) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" gene complement(2347132..2347306) /gene="tboG" /locus_tag="BSU_misc_RNA_39" downshifts complement(2347166) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" promotor_-35 2347281..2347286 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2347302..2347320 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2347310..2347329) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2347312..2348724 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2347312 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" upshifts complement(2347322) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" promotor_-35 complement(2347344..2347351) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2347346..2348113) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" gene complement(2347346..2348113) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" CDS complement(2348150..2348293) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" gene complement(2348150..2348293) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" S_feature complement(2348294..2348440) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2348441..2349346) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" gene complement(2348441..2349346) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" CDS complement(2349327..2349737) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" gene complement(2349327..2349737) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" promotor_-10 complement(2349775..2349794) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2349786) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" S_feature complement(2349788..2349855) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2349809..2349812) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2349856..2350227) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" gene complement(2349856..2350227) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" CDS complement(2350208..2350681) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" gene complement(2350208..2350681) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" CDS complement(2350682..2352817) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" gene complement(2350682..2352817) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" promotor_-35 2352661..2352666 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2352681 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2352682..2352700 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2352896..2353855) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" gene complement(2352896..2353855) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" downshifts complement(2352911) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" CDS complement(2353852..2355048) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" gene complement(2353852..2355048) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" promotor_-10 complement(2353919..2353938) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2353924) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" promotor_-35 complement(2353952..2353959) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2353999..2354017) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2354011) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" promotor_-35 complement(2354032..2354038) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2354226) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" promotor_-10 complement(2354240..2354251) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2354266..2354272) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2355067..2355348) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" gene complement(2355067..2355348) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" CDS complement(2355405..2355824) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" gene complement(2355405..2355824) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" downshifts complement(2355419) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" CDS complement(2355849..2356844) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" gene complement(2355849..2356844) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" CDS complement(2356866..2358179) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" gene complement(2356866..2358179) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" promotor_-10 complement(2358215..2358230) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2358232) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" promotor_-35 complement(2358243..2358252) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2358310..2358756) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" gene complement(2358310..2358756) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" downshifts complement(2358323) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" downshifts complement(2358521) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" CDS complement(2358771..2358944) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" gene complement(2358771..2358944) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" misc_feature 2358880..2358884 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2358885 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2359005..2359024) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2359020) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" promotor_-35 complement(2359038..2359045) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2359063..2359068 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2359083 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" promotor_-10 2359084..2359102 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2359117..2360040 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" gene 2359117..2360040 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" CDS complement(2360077..2361432) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" gene complement(2360077..2361432) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" downshifts complement(2360083) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" CDS complement(2361432..2362202) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" gene complement(2361432..2362202) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" CDS complement(2362225..2363160) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" gene complement(2362225..2363160) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" CDS complement(2363185..2364312) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" gene complement(2363185..2364312) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" misc_feature 2364229..2364232 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2364240 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2364313..2364490) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2364352..2364442 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" gene 2364352..2364442 /gene="surC" /locus_tag="BSU_misc_RNA_79" CDS complement(2364512..2366347) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" gene complement(2364512..2366347) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" downshifts complement(2364535) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" CDS complement(2366371..2366934) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" gene complement(2366371..2366934) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" S_feature complement(2366935..2367005) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2367006..2368037) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" gene complement(2367006..2368037) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" promotor_-10 complement(2368078..2368097) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2368091) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" promotor_-35 complement(2368112..2368119) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2368118..2369257) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" gene complement(2368118..2369257) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" promotor_-10 complement(2369130..2369141) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2369134) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" promotor_-35 complement(2369155..2369161) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2369310..2371148) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" gene complement(2369310..2371148) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" downshifts complement(2369332) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" promotor_-10 complement(2371183..2371202) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2371200) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" promotor_-35 complement(2371218..2371222) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2371282..2371620) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" gene complement(2371282..2371620) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" downshifts complement(2371288) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" CDS complement(2371637..2372842) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" gene complement(2371637..2372842) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" promotor_-10 complement(2372862..2372880) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2372874) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" promotor_-35 complement(2372896..2372901) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2372905..2374011) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" gene complement(2372905..2374011) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" promotor_-10 complement(2374039..2374050) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2374046) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" promotor_-35 complement(2374065..2374071) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2374110..2374113 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2374126 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" promotor_-10 2374129..2374148 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2374140..2374214 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2374215..2374481 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" gene 2374215..2374481 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" downshifts 2374470 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" CDS complement(2374496..2375539) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" gene complement(2374496..2375539) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" downshifts complement(2374541) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" promotor_-10 complement(2375568..2375587) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2375579..2375728) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" gene complement(2375579..2375728) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" upshifts complement(2375580) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" promotor_-35 complement(2375601..2375605) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2375603..2375942) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2375646) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" promotor_-35 2375715..2375721 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2375735..2375754 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2375736 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" CDS 2375769..2375903 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" gene 2375769..2375903 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" downshifts 2375897 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" CDS complement(2375943..2378273) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" gene complement(2375943..2378273) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" promotor_-10 complement(2375960..2375979) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2375976) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" promotor_-35 complement(2375993..2376002) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2378277..2378846) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" gene complement(2378277..2378846) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" promotor_-10 complement(2378873..2378892) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2378883) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" promotor_-35 complement(2378907..2378914) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2378913..2379530) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" gene complement(2378913..2379530) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" promotor_-35 2379551..2379556 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2379568 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" promotor_-10 2379572..2379590 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2379591..2379605) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2379593) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" S_feature complement(2379595..2380442) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2379614..2379618) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2379614..2380435 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" gene 2379614..2380435 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" promotor_-10 complement(2380430..2380449) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2380436..2380516 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2380443) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" promotor_-35 complement(2380463..2380470) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2380476 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" CDS complement(2380501..2381244) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" gene complement(2380501..2381244) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" downshifts complement(2380531) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" CDS complement(2381241..2381597) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" gene complement(2381241..2381597) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" CDS complement(2381615..2382175) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" gene complement(2381615..2382175) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" CDS complement(2382165..2382734) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" gene complement(2382165..2382734) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" CDS complement(2382746..2383036) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" gene complement(2382746..2383036) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" CDS complement(2383030..2383872) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" gene complement(2383030..2383872) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" downshifts 2383864 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" CDS complement(2383890..2384990) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" gene complement(2383890..2384990) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" CDS complement(2384994..2385512) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" gene complement(2384994..2385512) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" promotor_-10 complement(2385422..2385439) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2385436) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" promotor_-35 complement(2385455..2385458) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2385513..2386074) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2385546) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" promotor_-35 2385737..2385744 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2385755..2385855 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2385755..2385774 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2385755 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" misc_RNA complement(2385805..2386063) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" gene complement(2385805..2386063) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" CDS 2385856..2386014 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" gene 2385856..2386014 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" S_feature 2386015..2386261 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2386062..2386081) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2386073) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" promotor_-35 complement(2386097..2386101) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2386125..2386272) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2386162) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" downshifts 2386218 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" S_feature 2386263..2387316 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2386267..2386286) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2386272) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" promotor_-35 complement(2386299..2386308) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2386320..2387051) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipoprotein; putative esterase" /protein_id="NP_390447.1" /db_xref="EnsemblGenomes-Gn:BSU25700" /db_xref="EnsemblGenomes-Tr:CAB14511" /db_xref="GOA:P54451" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11634" /db_xref="UniProtKB/Swiss-Prot:P54451" /translation="MKHFIILFLLLFVTAGCEGRGYEDVVAFGDSNTRGSNWDYRDYP KAQQWVNILKTAERGNLDILNAGIGGQTTEDARLRFQTDVLDQKPKYLFIMFGTNDAA ILTEGKPRVSKQRFRENLVYFIEESRKHGIKPILMTCIPIIEGNGKHHLFYYSRYQAA AFEPKGGARKWHNSYNDITRDVSKRLDVPLVDNWKHFIEADGGKATDEALIQSGLIDP SGNHMTPKGARIVYEGIQDGQILQR*" gene complement(2386320..2387051) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" promotor_-10 complement(2387070..2387089) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2387086) /Source="Nicolas_upshifts" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" S_feature complement(2387088..2387196) /Source="Nicolas_S_feature" /locus_tag="new_2648688_2648796_c" /HighExp="Etha, Salt, Gly, S8, C30, S7, LPhT, Sw, Heat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S970" promotor_-35 complement(2387103..2387109) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2387197..2387215) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2387218) /Source="Nicolas_upshifts" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" promotor_-35 complement(2387230..2387235) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2387303..2388055) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" /EC_number="3.5.1.28" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10515909, 10974124, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10974124, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390448.1" /db_xref="EnsemblGenomes-Gn:BSU25710" /db_xref="EnsemblGenomes-Tr:CAB14512" /db_xref="GOA:P54450" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="SubtiList:BG11633" /db_xref="UniProtKB/Swiss-Prot:P54450" /translation="MVTIKKDFIPVSNDNRPGYAMAPAYITVHNTANTAKGADAKMHA KFVKNPNTSESWHFTVDDSVIYQHLPIDENGWHAGDGTNGTGNRKSIGIEICENADGD FEKATSNAQWLIRKLMKENNIPLNRVVPHKKWSGKECPRKLLDHWNSFLNGISSSDTP PKETSPSYPLPSGVIKLTSPYRKGTNILQLQKALAVLHFYPDKGAKNNGIDGVYGPKT ANAVKRFQLMNGLTADGIYGPKTKAKLKSKLK*" gene complement(2387303..2388055) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" downshifts complement(2387306) /Source="Nicolas_upshifts" /id="D1331" /incds=0 /nref=4 /ntot=10 /MaxReadThrough="1.29819" /MaxDrop="4.65121" /score="4.6304411" /energy="-10.7" /TU="NA" /idTUdmin="U2003" /TUdmin=0 /isTUend="TRUE" promotor_-35 2387434..2387440 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2387454..2387472 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2387461 /Source="Nicolas_upshifts" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2388065..2388084) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2388084) /Source="Nicolas_upshifts" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" promotor_-35 complement(2388098..2388106) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2388150..2388157 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2388172..2388191 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2388176..2388241 /Source="Nicolas_S_feature" /locus_tag="new_2649776_2649841" /HighExp="dia15, H2O2, C30, G180, Heat, S8, Paraq, Oxctl, LBGexp, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S971" upshifts 2388176 /Source="Nicolas_upshifts" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" CDS 2388242..2388868 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 15855514, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390449.1" /db_xref="EnsemblGenomes-Gn:BSU25720" /db_xref="EnsemblGenomes-Tr:CAB14513" /db_xref="GOA:P54449" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG11632" /db_xref="UniProtKB/Swiss-Prot:P54449" /translation="MLKKVIGILVIIAIISVGFFQKEAWLDAIKAGGMFSVLFSMLLI AADVFFPIVPFALIAALNGAVFGTANGIWITLTGSMLGTILLFFLARYSFRDWARKKV QAYPAIQSYEASFNKNAFTAVLLGRLIPVIPSLVMNVICGLSQVRWHVFFFASLIGKI PNIVVVTIAGANFTSNKLLSISIYGTYILIIMLVIYKKFPHLLKVPKK*" gene 2388242..2388868 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" downshifts 2388836 /Source="Nicolas_upshifts" /id="D1332" /incds=0 /nref=2 /ntot=63 /MaxReadThrough="2.9326" /MaxDrop="2.91074" /score="15.7108141" /energy="-10.3" /TU="U2004" /idTUdmin="U2004" /TUdmin="-22" /isTUend="TRUE" CDS complement(2388887..2389780) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10658669, 15231785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic 6-phospho-gluconate dehydrogenase (NAD[+]-dependent)" /protein_id="NP_390450.1" /db_xref="EnsemblGenomes-Gn:BSU25730" /db_xref="EnsemblGenomes-Tr:CAB14514" /db_xref="GOA:P54448" /db_xref="InterPro:IPR004849" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11631" /db_xref="UniProtKB/Swiss-Prot:P54448" /translation="MKIGLIGLGKMGINIGKQFIDRNHQVVGYDVNQAAVDELKAYGA EGTTNLKEFISLLHPPRILWVMVPHGIVDAVLRDVSPLLSKGDMIIEAGNSHYKESIR RYNQMKEAGIHYLDAGTSGGMEGARHGACFMVGGDHEAWEIVEPLFRDTAVENGYLYA GEAGSGHFLKMIHNGIEYGMMAAIGEGFEVLENSQFDFDYEKVARVWNHGSVIRSWLM GLTERAFAKDAKLDQIKGIMHSSGEGKWTVETALDLQTATPVIAMSLMMRYRSLTDDT FTGKVVAALRNEFGGHATEKK*" gene complement(2388887..2389780) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" downshifts complement(2388912) /Source="Nicolas_upshifts" /id="D1333" /incds=0 /nref=4 /ntot=12 /MaxReadThrough="1.46947" /MaxDrop="3.03963" /score="0.698755756" /energy="-8.4" /TU="NA" /idTUdmin="U2003" /TUdmin="-1606" /isTUend="FALSE" promotor_-35 2389963..2389969 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2389981..2390000 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2389981 /Source="Nicolas_upshifts" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" CDS 2390032..2390754 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390451.2" /db_xref="EnsemblGenomes-Gn:BSU25740" /db_xref="EnsemblGenomes-Tr:CAB14515" /db_xref="GOA:P54447" /db_xref="SubtiList:BG11630" /db_xref="UniProtKB/Swiss-Prot:P54447" /translation="MLQNQSHTLIGVTKTAVFFLYAALAIIGFAIGYFIPQIAKWALS LPWIPLEGPLRLITSFQGSTASFITALLGMCAGIWFAHSVIAMLLSVKITDHTVEFIK GKKVQTIHSDDIALVFMDHKRLVLLGTAGYELVREEIDEKPVNVEKAFRQHHYEWATD GDPFKDQFRRWIPDAPDLSQGAHALLKARHKALQDEEKDDIEEFRLELAQLGIVVRDE GTRQYWRKAETYPPKIQLGEGL*" gene 2390032..2390754 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" CDS complement(2390787..2391197) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7746143, 17209033, 21179489" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746143, 17209033, 21179489; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific matrix degrading exported DNase" /protein_id="NP_390452.1" /db_xref="EnsemblGenomes-Gn:BSU25750" /db_xref="EnsemblGenomes-Tr:CAB14516" /db_xref="GOA:P42983" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG11237" /db_xref="UniProtKB/Swiss-Prot:P42983" /translation="MKKWMAGLFLAAAVLLCLMVPQQIQGASSYDKVLYFPLSRYPET GSHIRDAIAEGHPDICTIDRDGADKRREESLKGIPTKPGYDRDEWPMAVCEEGGAGAD VRYVTPSDNRGAGSWVGNQMSSYPDGTRVLFIVQ*" gene complement(2390787..2391197) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" downshifts complement(2390812) /Source="Nicolas_upshifts" /id="D1334" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="0.80212" /MaxDrop="3.40706" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2006" /TUdmin="-11" /isTUend="TRUE" promotor_-10 complement(2391217..2391235) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2391219) /Source="Nicolas_upshifts" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" promotor_-35 complement(2391251..2391256) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2391320..2391328 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2391341 /Source="Nicolas_upshifts" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" promotor_-10 2391342..2391361 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2391393..2391863 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (N-terminal half)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14517.2" /db_xref="SubtiList:BG10459" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MVTGVFAALGFVVKELVFLVSYVKNNAFPQPLSSSEEKKYLELM AKGDEHARNMLIEHNLRLVAHIVKKFENTGEDAEDLISIGTIGLIKGIESYSAGKGTK LATYAARCIENEIVITKGGCIHPSLIRFNIYGVRIHNGNFFHDKVNNCFFIFKS*" gene 2391393..2391863 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /pseudo downshifts 2391583 /Source="Nicolas_upshifts" /id="D1335" /incds=1 /nref=2 /ntot=5 /MaxReadThrough="7.53734" /MaxDrop="3.01863" /score="-7.46047649" /energy="-12.1" /TU="U2007" /idTUdmin="U2007" /TUdmin="-132" /isTUend="FALSE" downshifts 2391715 /Source="Nicolas_upshifts" /id="D1336" /incds=1 /nref=44 /ntot=61 /MaxReadThrough="0.8049" /MaxDrop="7.21386" /score="-7.46047649" /energy="-12.1" /TU="NA" /idTUdmin="U2007" /TUdmin=0 /isTUend="TRUE" CDS complement(2391771..2393273) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific DNA recombinase; skin element" /protein_id="NP_390454.2" /db_xref="EnsemblGenomes-Gn:BSU25770" /db_xref="EnsemblGenomes-Tr:CAB14518" /db_xref="GOA:P17867" /db_xref="InterPro:IPR006118" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG10458" /db_xref="UniProtKB/Swiss-Prot:P17867" /translation="MIAIYVRVSTEEQAIKGSSIDSQIEACIKKAGTKDVLKYADEGF SGELLERPALNRLREDASKGLISQVICYDPDRLSRKLMNQLIIDDELRKRNIPLIFVN GEYANSPEGQLFFAMRGAISEFEKAKIKERTSSGRLQKMKKGMIIKDSKLYGYKFVKE KRTLEILEEEAKIIRMIFNYFTDHKSPFFGRVNGIALHLTQMGVKTKKGAKVWHRQVV RQILMNSSYKGEHRQYKYDTEGSYVSKQAGNKSIIKIRPEEEQITVTIPAIVPAEQWD YAQELLGQSKRKHLSISPHNYLLSGLVRCGKCGNTMTGKKRKSHGKDYYVYTCRKNYS GAKDRGCGKEMSENKLNRHVWGEIFKFITNPQKYVSFKEAEQSNHLSDELELIEKEIE KTKKGRKRLLTLISLSDDDDLDIDEIKAQIIELQKKQNQLTEKCNEIQSKMKVLDDTS SSENALKRAIDYFQSIGADNLTLEDKKTIVNFIVKEVTIVDSDTIYIETY*" gene complement(2391771..2393273) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" downshifts complement(2391787) /Source="Nicolas_upshifts" /id="D1337" /incds=1 /nref=21 /ntot=131 /MaxReadThrough="2.50085" /MaxDrop="6.35891" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2008" /TUdmin=4 /isTUend="TRUE" promotor_-10 complement(2393380..2393398) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2393398) /Source="Nicolas_upshifts" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" S_feature complement(2393400..2393701) /Source="Nicolas_S_feature" /locus_tag="new_2655000_2655301_c" /HighExp="dia5, Diami, S8, S7, dia15, C30, G135, S6, G180, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.974" /TUlongSig="NA" /TUlongPSig="NA" /label="S972" promotor_-35 complement(2393415..2393420) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2393722..2394141) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" /EC_number="1.20.4.4" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin-coupled arsenate reductase; skin element" /protein_id="NP_390455.1" /db_xref="EnsemblGenomes-Gn:BSU25780" /db_xref="EnsemblGenomes-Tr:CAB14519" /db_xref="GOA:P45947" /db_xref="InterPro:IPR014064" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1JL3" /db_xref="PDB:1Z2D" /db_xref="PDB:1Z2E" /db_xref="PDB:2IPA" /db_xref="SubtiList:BG11304" /db_xref="UniProtKB/Swiss-Prot:P45947" /translation="MENKIIYFLCTGNSCRSQMAEGWAKQYLGDEWKVYSAGIEAHGL NPNAVKAMKEVGIDISNQTSDIIDSDILNNADLVVTLCGDAADKCPMTPPHVKREHWG FDDPARAQGTEEEKWAFFQRVRDEIGNRLKEFAETGK*" gene complement(2393722..2394141) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" downshifts complement(2393746) /Source="Nicolas_upshifts" /id="D1338" /incds=0 /nref=106 /ntot=239 /MaxReadThrough="3.85143" /MaxDrop="6.98965" /score="17.1730317" /energy="-8.6" /TU="U2009" /idTUdmin="U2009" /TUdmin="-1823" /isTUend="FALSE" CDS complement(2394153..>2394281) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9537360, 15849754, 16850406, 16905151; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite efflux transporter; skin element" /protein_id="NP_390456.2" /db_xref="EnsemblGenomes-Gn:BSU25790" /db_xref="EnsemblGenomes-Tr:CAB14520" /db_xref="GOA:P45946" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004706" /db_xref="SubtiList:BG11303" /db_xref="UniProtKB/Swiss-Prot:P45946" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /translation="YRIHSGAAFAAVIGPLVEVPVMIALVKVALWFQRKYFGSHSM*" /label="Delta6_pseudo_BSU_25790" gene complement(2394153..>2394281) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /label="Delta6_pseudo_BSU_25790" SCAR join(2394277,2394284) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="TFC7A" N_region 2394278..2394283 /note="EcoRV side (GATATC)" /created_by="User" /modified_by="User" /label="TFC7A" CDS <2394279..2394665 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /inference="COORDINATES: similar to AA sequence:RefSeq:NP_390515.1" /note="incomplete; partial in the middle of a contig; missing N-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology." /pseudo /codon_start=1 /transl_table=11 /product="ImmA/IrrE family metallo-endopeptidase" /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /translation="ISSFALKHSGIYNICLDSRKSRTEQWYDFAHEFCHIYRHEGDKK TMPATWTDYLDWQSNYFTYHFCIPTCMLRNINLPYIQSHAIENVAWLFKVSPSFAKKR LSIYYRKLTQHLFSQTVTGNLCPPFL*" /label="Delta6_pseudo_BSU_26380" gene <2394279..2394665 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /pseudo /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /label="Delta6_pseudo_BSU_26380" misc_feature complement(2394632..2394650) /Source="Nicolas_upshift_promotors" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2394647..2395063 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2163341, 7704261, 8969508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2163341, 7704261, 8969508; Product type f: factor" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (C-terminal fragment)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14580.1" /db_xref="SubtiList:BG10919" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MPPLFVMNNEILMHLRALKKTKKDVSLHDPIGQDKEGNEISLID VLKSENEDVIDTIQLNMELEKVKQYIDILDDREKEVIVGRFGLDLKKEKTQREIAKEL GISRSYVSRIEKRALMKMFHEFYRAEKEKRKKAKGK*" gene 2394647..2395063 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /pseudo misc_feature 2394652..2394666 /Source="Nicolas_upshift_promotors" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2394660) /Source="Nicolas_upshifts" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts 2394671 /Source="Nicolas_upshifts" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" downshifts 2395047 /Source="Nicolas_upshifts" /id="D1357" /incds=0 /nref=50 /ntot=108 /MaxReadThrough="3.60274" /MaxDrop="5.60264" /score="-0.848064104" /energy="-4.5" /TU="U2035" /idTUdmin="U2033" /TUdmin=1 /isTUend="TRUE" CDS 2395063..2395179 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513982.1" /translation="MQKKPDLILRLSLFERVMKIIFFIADKLSEKDRQDRNK*" gene 2395063..2395179 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" S_feature 2395092..2396426 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" downshifts complement(2395210) /Source="Nicolas_upshifts" /id="D1358" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="3.25265" /MaxDrop="3.18978" /score="3.17084908" /energy="-14.7" /TU="NA" /idTUdmin="U2036" /TUdmin=66 /isTUend="FALSE" CDS complement(2395288..2395452) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390517.1" /db_xref="EnsemblGenomes-Gn:BSU26400" /db_xref="EnsemblGenomes-Tr:CAB14581" /db_xref="SubtiList:BG11785" /db_xref="UniProtKB/Swiss-Prot:P54446" /translation="MKVIIIEGLQTDKCMNDCYHYLIKLYRQEIQGDSNISWNKRSRD RASTARSRPV*" gene complement(2395288..2395452) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" promotor_-10 complement(2395382..2395401) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2395408) /Source="Nicolas_upshifts" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" promotor_-35 complement(2395416..2395423) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2395586) /Source="Nicolas_upshifts" /id="D1359" /incds=0 /nref=79 /ntot=219 /MaxReadThrough="1.20909" /MaxDrop="4.40328" /score="39.3560776" /energy="-10.6" /TU="NA" /idTUdmin="U2036" /TUdmin="-310" /isTUend="FALSE" CDS complement(2395997..2396413) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" gene complement(2395997..2396413) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" CDS complement(2396459..2397757) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" gene complement(2396459..2397757) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" CDS complement(2397744..2398439) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" gene complement(2397744..2398439) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" misc_feature complement(2398505..2398522) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2398514) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" promotor_-35 2398600..2398606 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2398613..2398631 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2398628 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2398707..2399924 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" gene 2398707..2399924 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" promotor_-35 2399166..2399173 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2399188..2399207 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2399204 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2399843..2400091 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" gene 2399843..2400091 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" S_feature complement(2400020..2401067) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2400436..2400993 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" gene 2400436..2400993 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" S_feature 2400994..2401116 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2401069..2401483) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2401112) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" CDS complement(2401484..2402008) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" gene complement(2401484..2402008) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" promotor_-35 2401856..2401863 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2401874..2401893 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2401888 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2402009..2402096) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2402091..2402110) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2402096) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" S_feature complement(2402098..2402251) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2402125..2402132) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2402252..2402728) /gene="yrkK" /locus_tag="BSU_26480" /old_locus_tag="BSU26480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390525.2" /db_xref="EnsemblGenomes-Gn:BSU26480" /db_xref="EnsemblGenomes-Tr:CAB14589" /db_xref="GOA:P54438" /db_xref="InterPro:IPR025671" /db_xref="SubtiList:BG11777" /db_xref="UniProtKB/Swiss-Prot:P54438" /translation="MVYFVAFFCFAITLHNIEEAIWLPEWSQQSSKFQKPVTSNEFHF AVIVITMLAYLSAFGFLYMPESDIAKWIFIGFLGSMVINAIFPHLIATVVMKKYAPGL LTGLLLNIPVNSLVIYQMFLKNLIVWKELIISTLVVGIILLALIPLLFKVGDKVSP*" gene complement(2402252..2402728) /gene="yrkK" /locus_tag="BSU_26480" /old_locus_tag="BSU26480" promotor_-10 complement(2402764..2402783) /Source="Nicolas_upshift_promotors" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2402778) /Source="Nicolas_upshifts" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" S_feature complement(2402780..2403310) /Source="Nicolas_S_feature" /locus_tag="new_2709471_2710001_c" /HighExp="Diami, dia15, S8, G180, Etha, G135, S6, S0, G150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S990" promotor_-35 complement(2402797..2402804) /Source="Nicolas_upshift_promotors" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2403311..2404096) /gene="yrkJ" /locus_tag="BSU_26490" /old_locus_tag="BSU26490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_390526.1" /db_xref="EnsemblGenomes-Gn:BSU26490" /db_xref="EnsemblGenomes-Tr:CAB14590" /db_xref="GOA:P54437" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG11776" /db_xref="UniProtKB/Swiss-Prot:P54437" /translation="MDIAFITTLFIIGFIGAFISGMIGIGGAVINYPMLLYIPSLVGV MSLTAHEVSGIGAIQVFFATLGGVWAYRKSGLINKTLIIYMGSSILLGSVLGSYFSHY ISEKGINFIYGILAIIAVILMFIPKKGQKGQEHSEDKEVIFNKWLASSLAFIIGGVSG ILGAGGAFILVPIMLSILNIPVRVTVASSLAITFLSSIGATVGKVITGQVLFVPALVL MITSLIASPIGASVGQKVNTKFLQWVLAQLIGATAIKIWLELL*" gene complement(2403311..2404096) /gene="yrkJ" /locus_tag="BSU_26490" /old_locus_tag="BSU26490" CDS complement(2404157..2404384) /gene="yrkI" /locus_tag="BSU_26500" /old_locus_tag="BSU26500" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9555915; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur-carrier protein" /protein_id="NP_390527.1" /db_xref="EnsemblGenomes-Gn:BSU26500" /db_xref="EnsemblGenomes-Tr:CAB14591" /db_xref="GOA:P54436" /db_xref="InterPro:IPR001455" /db_xref="InterPro:IPR036868" /db_xref="SubtiList:BG11775" /db_xref="UniProtKB/Swiss-Prot:P54436" /translation="MKSDKVLDAKGLACPMPIVRTKKAMNELESGQILEVHATDKGAK NDLTAWSKSGGHDLLEQTDEGDILKFWIQKG*" gene complement(2404157..2404384) /gene="yrkI" /locus_tag="BSU_26500" /old_locus_tag="BSU26500" downshifts complement(2404181) /Source="Nicolas_upshifts" /id="D1361" /incds=0 /nref=4 /ntot=22 /MaxReadThrough="5.31659" /MaxDrop="3.95633" /score="-3.35079978" /energy="-23.7" /TU="U2044,U2045" /idTUdmin="U2046" /TUdmin=3085 /isTUend="FALSE" CDS complement(2404418..2405551) /gene="yrkH" /locus_tag="BSU_26510" /old_locus_tag="BSU26510" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase / hydrolase" /protein_id="NP_390528.2" /db_xref="EnsemblGenomes-Gn:BSU26510" /db_xref="EnsemblGenomes-Tr:CAB14592" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036866" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11774" /db_xref="UniProtKB/Swiss-Prot:P54435" /translation="MKHDRKGNDPKRSDKKIFNKEPLFILDVRNENDFSDWKIEGHDF DHLNVPYFDLLDGVEDILEKIPSDKEVLVVCAKEGSSVMVSEMLSEAGHSVSYLKGGM KAWSEHLEPVKVGDLKDGGEMYQFVRIGKGCLSYMVISNGEAAIIDATRMVNFFIDFA KGKGATITHVFDTHLHADHISGGRVIAEKTKATYWLPPKDAEEVEFDYQPLEEGNDII IGNTTIKIQPIYSPGHTIGSTSFIVDDQYLLSGDILFIDSIGRPDLAGMAEDWVGDLR KTLYSRYKALSKDLIVLPAHFMIIDELNENGSVGKQLSTLFSENHGLNIADETEFRHL VTDHLPPQPNAYQEIRETNMGKISPDEEKQREMEIGPNRCAIR*" gene complement(2404418..2405551) /gene="yrkH" /locus_tag="BSU_26510" /old_locus_tag="BSU26510" misc_feature complement(2405253..2405268) /Source="Nicolas_upshift_promotors" /id="U2043" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.410589410589411" /psig="0.477522477522478" /xcortree=1482 /SigmaFactorBS="aaaagaaggttcatccgtcatggtatccgaaatgctttctga agcaggtcattctgTATCCTACCTTAAGGGtggaatgaaagcatggagcgaacattta g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2405264) /Source="Nicolas_upshifts" /id="U2043" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.410589410589411" /psig="0.477522477522478" /xcortree=1482 /SigmaFactorBS="aaaagaaggttcatccgtcatggtatccgaaatgctttctga agcaggtcattctgTATCCTACCTTAAGGGtggaatgaaagcatggagcgaacattta g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2405552..2405885) /Source="Nicolas_S_feature" /locus_tag="new_2712243_2712576_c" /HighExp="Diami, dia15, Sw, BC, S0, G180, dia5, G135, M9-stat, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99950300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S991" CDS complement(2405886..2406443) /gene="yrkF" /locus_tag="BSU_26530" /old_locus_tag="BSU26530" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhodanese-related sulfur transferase" /protein_id="NP_390530.1" /db_xref="EnsemblGenomes-Gn:BSU26530" /db_xref="EnsemblGenomes-Tr:CAB14594" /db_xref="InterPro:IPR001455" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036868" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11772" /db_xref="UniProtKB/Swiss-Prot:P54433" /translation="MMKATIVLDAKGLACPMPIVKTKKRMKDLKAGEVLEIHATDKGS TADLEAWAKSTGHEYLGTEAEGEILRHFLRKGGEHSSENASSIPEISLEAFKQKVDSD ESLNILDVREIEEYEKAHIPGVVHIPLGEVEKRANELNENDEIYIICHSGRRSEMAAR TMKKQGFKKVINVVPGMRDWTGKTE*" gene complement(2405886..2406443) /gene="yrkF" /locus_tag="BSU_26530" /old_locus_tag="BSU26530" S_feature complement(2406444..2406628) /Source="Nicolas_S_feature" /locus_tag="new_2713135_2713319_c" /HighExp="Diami, dia15, Sw, BC, S8, dia5, G180, S7, S0, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12629799999999999" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S992" CDS complement(2406629..2407111) /gene="yrkE" /locus_tag="BSU_26540" /old_locus_tag="BSU26540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein involved in sulfur metabolism (DsrE-like)" /protein_id="NP_390531.1" /db_xref="EnsemblGenomes-Gn:BSU26540" /db_xref="EnsemblGenomes-Tr:CAB14595" /db_xref="InterPro:IPR027396" /db_xref="InterPro:IPR032836" /db_xref="SubtiList:BG11771" /db_xref="UniProtKB/Swiss-Prot:P54432" /translation="MTEQTKRTTIVLFSGDYDKAMAAYIIANGAAAYDHEVTIFHTFW GFNALRKEELIPVKKGFLEKMFGKMMPRGADKMGLSKMNFAGMGPKMIKNVMKKHNVL TLPQLIEMAQEQGVKLVACTMTMDLLGLQEKELLDDIDYAGVAAYLADAEEGSVNLFI *" gene complement(2406629..2407111) /gene="yrkE" /locus_tag="BSU_26540" /old_locus_tag="BSU26540" S_feature complement(2407112..2407220) /Source="Nicolas_S_feature" /locus_tag="new_2713803_2713911_c" /HighExp="Diami, dia15, Sw, BC, dia5, S8, G180, S6, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S993" CDS complement(2407258..2407449) /gene="yrkD" /locus_tag="BSU_26550" /old_locus_tag="BSU26550" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21339296; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative metal-sensitive transcriptional regulator involved in sulfur metabolism" /protein_id="NP_390532.1" /db_xref="EnsemblGenomes-Gn:BSU26550" /db_xref="EnsemblGenomes-Tr:CAB14596" /db_xref="GOA:P54431" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG11770" /db_xref="UniProtKB/Swiss-Prot:P54431" /translation="MMEQGKDCREVVTQLAASRNAIDRAMGLIVSTNLEHCVRESLEK GEDTQNLVKEAVDLLVKSR*" gene complement(2407258..2407449) /gene="yrkD" /locus_tag="BSU_26550" /old_locus_tag="BSU26550" downshifts complement(2407265) /Source="Nicolas_upshifts" /id="D1362" /incds=0 /nref=153 /ntot=252 /MaxReadThrough="8.17686" /MaxDrop="5.42995" /score="-6.39526496" /energy="-7.9" /TU="U2044,U2045" /idTUdmin="U2046" /TUdmin=1 /isTUend="TRUE" S_feature complement(2407450..2407539) /Source="Nicolas_S_feature" /locus_tag="new_2714141_2714230_c" /HighExp="Diami, dia15, S6, S7, S8, Etha, dia5, S5, BC, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="1, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S994" CDS complement(2407540..2407857) /gene="yrzM" /locus_tag="BSU_26558" /old_locus_tag="BSU26558" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="PSEUDO:CAX52666.1" /translation="MIIIATYRRYYPITGISCIHKDKLEAMDITILDIRHYNDVANFS DNIILNIPYAYLKRFYLEIPRDKIHIIARDRVELNLGVRFLKRKGIHVNSYELATCKC KNK*" gene complement(2407540..2407857) /gene="yrzM" /locus_tag="BSU_26558" /old_locus_tag="BSU26558" /pseudo promotor_-10 complement(2407646..2407665) /Source="Nicolas_upshift_promotors" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2407662) /Source="Nicolas_upshifts" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" promotor_-35 complement(2407678..2407684) /Source="Nicolas_upshift_promotors" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2407899..2408114) /gene="yrzN" /locus_tag="BSU_26559" /old_locus_tag="BSU26559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52667.1" /translation="MINKADLKLNRLIALFEFLLAELALSNVSIFSIRGYRNESISSK KVTFTLDYIPMGVYYCFVNKQRVNKVV*" gene complement(2407899..2408114) /gene="yrzN" /locus_tag="BSU_26559" /old_locus_tag="BSU26559" /pseudo promotor_-10 complement(2407927..2407946) /Source="Nicolas_upshift_promotors" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2407941) /Source="Nicolas_upshifts" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" promotor_-35 complement(2407961..2407968) /Source="Nicolas_upshift_promotors" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2408115..2408241) /Source="Nicolas_S_feature" /locus_tag="new_2714806_2714932_c" /HighExp="S6, S7, S8, S5, BT, B36, G/S, BC, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.114547" /TUshortSig="SigK, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S995" CDS complement(2408242..2408802) /gene="yrkC" /locus_tag="BSU_26560" /old_locus_tag="BSU26560" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_390533.1" /db_xref="EnsemblGenomes-Gn:BSU26560" /db_xref="EnsemblGenomes-Tr:CAB14597" /db_xref="GOA:P54430" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG11769" /db_xref="UniProtKB/Swiss-Prot:P54430" /translation="MYYNPFSPQCYYYVTVPMYNDGRSVYWTIPNEMEKVHRGADLRS SYEDRNLLLKDYGPKPFVVNINRATKQNNTFRTALWTGKHFQVTLMSLGIGEDIGLEI HPNVDQFLRIEQGRGIVKMGKSKDHLNFQRNVYDDSAIVVPAGTWHNVINTGNTPLKL YSIYAPPNHPFGTVHETKADAVAAED*" gene complement(2408242..2408802) /gene="yrkC" /locus_tag="BSU_26560" /old_locus_tag="BSU26560" CDS complement(2408819..2408995) /locus_tag="BSU_26569" /old_locus_tag="BSU26569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513984.1" /translation="MLTKASEIQHLENDYKVGDKLFIHESNGDRTFIFVFNMSFLDLA HSLNKCIGYYHKNL*" gene complement(2408819..2408995) /locus_tag="BSU_26569" /old_locus_tag="BSU26569" promotor_-10 complement(2408829..2408848) /Source="Nicolas_upshift_promotors" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2408840) /Source="Nicolas_upshifts" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" S_feature complement(2408842..2409027) /Source="Nicolas_S_feature" /locus_tag="new_2715533_2715718_c" /HighExp="BC, Sw, S3, dia15, Etha, S4, S5, H2O2, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.49093999999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S996" promotor_-35 complement(2408861..2408870) /Source="Nicolas_upshift_promotors" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2409028..2409174) /gene="yrkB" /locus_tag="BSU_26570" /old_locus_tag="BSU26570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390534.1" /db_xref="EnsemblGenomes-Gn:BSU26570" /db_xref="EnsemblGenomes-Tr:CAB14598" /db_xref="SubtiList:BG11768" /db_xref="UniProtKB/Swiss-Prot:P54429" /translation="MLLKNWPSRRIQRDKSKRAGIGGTNNRIPYTLLLCYVNVQKPFR IVDL*" gene complement(2409028..2409174) /gene="yrkB" /locus_tag="BSU_26570" /old_locus_tag="BSU26570" CDS complement(2409344..2410165) /gene="bltR" /locus_tag="BSU_26580" /old_locus_tag="BSU26580" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7608059, 9083003, 10200972, 21954605" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7608059, 9083003, 10200972, 21954605; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (polyamine metabolism)" /protein_id="NP_390535.1" /db_xref="EnsemblGenomes-Gn:BSU26580" /db_xref="EnsemblGenomes-Tr:CAB14599" /db_xref="GOA:P39842" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="SubtiList:BG10904" /db_xref="UniProtKB/Swiss-Prot:P39842" /translation="MSEDVKKYFTTGEFSKLCRVKKQTLFHYDEIGLFSPEIKKENGY RYYSYHQFETFQVISLFKELGVPLKEIKCLIKGKTPDKILHVLKEKSIEIDKKINELK QLQTILQTKVTLTEQALETDFSSISFEYLNEETFMLSRKTLNLPERKYVAAISELIHE VQQYELDEGYPIGGIFAREQILEKDFYNYSYFYIKVKDGAENINYHVRPKGLYAVGYE IGGNTEEAYRRIIEFIERNGMQIGENAYEEYMLDEMVVDGYENTYAKILLQVKEV*" gene complement(2409344..2410165) /gene="bltR" /locus_tag="BSU_26580" /old_locus_tag="BSU26580" promotor_-35 2410173..2410180 /Source="Nicolas_upshift_promotors" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2410175..2410194) /Source="Nicolas_upshift_promotors" /id="U2047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.966033966033966" /xcortree=1901 /SigmaFactorBS="tttttacctatccttttcgcttgaagcttttttcaagtacaa tcaaatcataaggtatATGGTTACCGTATAGTCAAGgaggtttttatgagcgaagatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2410192) /Source="Nicolas_upshifts" /id="U2047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.966033966033966" /xcortree=1901 /SigmaFactorBS="tttttacctatccttttcgcttgaagcttttttcaagtacaa tcaaatcataaggtatATGGTTACCGTATAGTCAAGgaggtttttatgagcgaagatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2410194..2412198) /Source="Nicolas_S_feature" /locus_tag="new_2716885_2718889_c" /HighExp="BC, Sw, Salt, Mal, T4.0H, M9-stat, T3.30H, G180, G135, MG 5" /AntisenseName="blt" /AntisenseCor="0.56943492854420497" /AntisenseRegPval="-23.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S997" promotor_-10 2410196..2410215 /Source="Nicolas_upshift_promotors" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2410204 /Source="Nicolas_upshifts" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" CDS 2410282..2411484 /gene="blt" /locus_tag="BSU_26590" /old_locus_tag="BSU26590" /function="16.1: Circulate" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9083003, 10200972, 10359661, 12793527, 15849754, 16850406, 19114526, 21954605" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9083003, 10200972, 10359661, 12793527, 15849754, 16850406, 19114526, 21954605; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (promiscuous, acetylated polyamines efflux)" /protein_id="NP_390536.1" /db_xref="EnsemblGenomes-Gn:BSU26590" /db_xref="EnsemblGenomes-Tr:CAB14600" /db_xref="GOA:P39843" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR004734" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10905" /db_xref="UniProtKB/Swiss-Prot:P39843" /translation="MKKSINEQKTIFIILLSNIFVAFLGIGLIIPVMPSFMKIMHLSG STMGYLVAAFAISQLITSPFAGRWVDRFGRKKMIILGLLIFSLSELIFGLGTHVSIFY FSRILGGVSAAFIMPAVTAYVADITTLKERSKAMGYVSAAISTGFIIGPGAGGFIAGF GIRMPFFFASAIALIAAVTSVFILKESLSIEERHQLSSHTKESNFIKDLKRSIHPVYF IAFIIVFVMAFGLSAYETVFSLFSDHKFGFTPKDIAAIITISSIVAVVIQVLLFGKLV NKLGEKRMIQLCLITGAILAFVSTVMSGFLTVLLVTCFIFLAFDLLRPALTAHLSNMA GNQQGFVAGMNSTYTSLGNIFGPALGGILFDLNIHYPFLFAGFVMIVGLGLTMVWKEK KNDAAALN*" gene 2410282..2411484 /gene="blt" /locus_tag="BSU_26590" /old_locus_tag="BSU26590" CDS 2411653..2412111 /gene="bltD" /locus_tag="BSU_26600" /old_locus_tag="BSU26600" /EC_number="2.3.1.57" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10200972, 10359661, 12793527, 9083003, 16210326, 21954605, 28197687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10359661, 12793527, 9083003, 16210326, 21954605, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermine/spermidine acetyltransferase" /protein_id="NP_390537.1" /db_xref="EnsemblGenomes-Gn:BSU26600" /db_xref="EnsemblGenomes-Tr:CAB14601" /db_xref="GOA:P39909" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027455" /db_xref="SubtiList:BG10906" /db_xref="UniProtKB/Swiss-Prot:P39909" /translation="MSINIKAVTDDNRAAILDLHVSQNQLSYIESTKVCLEDAKECHY YKPVGLYYEGDLVGFAMYGLFPEYDEDNKNGRVWLDRFFIDERYQGKGLGKKMLKALI QHLAELYKCKRIYLSIFENNIHAIRLYQRFGFQFNGELDFNGEKVMVKEL*" gene 2411653..2412111 /gene="bltD" /locus_tag="BSU_26600" /old_locus_tag="BSU26600" downshifts complement(2412243) /Source="Nicolas_upshifts" /id="D1363" /incds=0 /nref=77 /ntot=211 /MaxReadThrough="5.09534" /MaxDrop="4.8114" /score="-0.00168005652" /energy="-10.7" /TU="U2049" /idTUdmin="U2051" /TUdmin=3845 /isTUend="FALSE" CDS complement(2412268..2413572) /gene="yrkA" /locus_tag="BSU_26610" /old_locus_tag="BSU26610" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative membrane associated protein" /protein_id="NP_390538.1" /db_xref="EnsemblGenomes-Gn:BSU26610" /db_xref="EnsemblGenomes-Tr:CAB14602" /db_xref="GOA:P54428" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11767" /db_xref="UniProtKB/Swiss-Prot:P54428" /translation="MTTINLIIFTLLIVLTAFFVATEFAIVKIRSSKIDQLILEGKKG AISAKKVITHLDEYLSACQLGITVTALGIGWVGESTFEVILHPLFAHFHVSETVSHVL ILVIAFVMATFLHVVVGELAPKTLAIQKAETITLLTAKPIIWFYRILFPFIWFLNGSA RFIVGLFGLKPASEHELAHSEEELRILLSESYKSGEINQNELKYVNNIFEFDERIAKE IMIPRREIVAISSEDSYETIVKIIKTESYTRYPVLNGDKDSIIGFINAKEFLSAYIDT DQKIKEDFKLENHINPVIHVIESVPIHDVLVKMQKERTHIAILVDEYGGTSGLVTAED ILEEIVGEIRDEFDKDEVPNIRKVNDNHYILDSKVLIEDVNDLLGTTLASDEVDTIGG WFMTQQIDAAVGSVIEADGYIFKVHETVGRHINYLEIVRKKE*" gene complement(2412268..2413572) /gene="yrkA" /locus_tag="BSU_26610" /old_locus_tag="BSU26610" S_feature complement(2413573..2413652) /Source="Nicolas_S_feature" /locus_tag="new_2720264_2720343_c" /HighExp="BC, Sw, MG 15, Mal, Salt, MG 25, MG-0.2, MG 45, MG 5, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S998" promotor_-10 complement(2413638..2413657) /Source="Nicolas_upshift_promotors" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2413652) /Source="Nicolas_upshifts" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" promotor_-35 complement(2413672..2413679) /Source="Nicolas_upshift_promotors" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2413835..2413978) /gene="yrzO" /locus_tag="BSU_26619" /old_locus_tag="BSU26619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097765.1" /db_xref="EnsemblGenomes-Gn:BSU26619" /db_xref="EnsemblGenomes-Tr:CAX52668" /db_xref="InterPro:IPR025417" /db_xref="UniProtKB/Swiss-Prot:C0H458" /translation="MFEGLLFFISAGIVCELAAINRNGRKNIKQQAELIQILKENLYK DIK*" gene complement(2413835..2413978) /gene="yrzO" /locus_tag="BSU_26619" /old_locus_tag="BSU26619" CDS complement(2413996..2414961) /gene="yrdR" /locus_tag="BSU_26620" /old_locus_tag="BSU26620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390539.1" /db_xref="EnsemblGenomes-Gn:BSU26620" /db_xref="EnsemblGenomes-Tr:CAB14603" /db_xref="GOA:O07086" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12289" /db_xref="UniProtKB/Swiss-Prot:O07086" /translation="MKKGQLFIGALTCLVASMSWGAMFPVADHALEFVDPFYFSFIRY GVVTIMLVILLLVREGKKSFHLEGKAKWIILFGVMAFTIYNVLIFLGQRLMGKSGIMT ASIAEALMPMLSIVILWGYKHVKPKKYTMISILIAFLGASMVITKGNISFFFSLGDHL FSILFIFIGVLGWVVYTMGGQIFREWSTLRYSTLTCLFGTAITGIMTAILTAQGYVSV PSIKVIAAIKYDFLFMITLPGIIALLSWNYGIKILSSINGILFINFVPITTLLIMVIK GYNITAFDIVGTLFVIIGLILNNIYQRKEDYKQVLQKEKTNLTIT*" gene complement(2413996..2414961) /gene="yrdR" /locus_tag="BSU_26620" /old_locus_tag="BSU26620" promotor_-35 2414999..2415002 /Source="Nicolas_upshift_promotors" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2415017..2415036 /Source="Nicolas_upshift_promotors" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2415044 /Source="Nicolas_upshifts" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" CDS 2415087..2415953 /gene="czcR" /locus_tag="BSU_26630" /old_locus_tag="BSU26630" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 22666466, 25437189; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_390540.1" /db_xref="EnsemblGenomes-Gn:BSU26630" /db_xref="EnsemblGenomes-Tr:CAB14604" /db_xref="GOA:P71025" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12288" /db_xref="UniProtKB/Swiss-Prot:P71025" /translation="MELRDLQIFKCVAHHKSITGAAKELNYVQSNVTARIKQLENELK TPLFNRHKKGVSLSPEGRKMIEYVNKILKDVEELEQVFLDTEIPSGILKIGTVETVRI LPTIIASYYKKYPNVDLSLQAGLTEELIKKVMNHELDGAFISGPLKHSILEQYDVYTE KLTLVTSNKTFNIEDFSTTPILVFNQGCGYRSRLEQWLKDEGVLPNRMMEFNILETIL NSVALGLGITVVPESAVMHLAVQGKVYCHPLPEKDSCISTIFIRHKDAYLTNSMRSLL KTIVEHKNMSMA*" gene 2415087..2415953 /gene="czcR" /locus_tag="BSU_26630" /old_locus_tag="BSU26630" S_feature 2415954..2416054 /Source="Nicolas_S_feature" /locus_tag="new_2722645_2722745" /HighExp="HiTm, dia15, LBGstat, LPhT, T0.30H, Diami, Paraq, dia5, H2O2, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.905" /TUlongSig="NA" /TUlongPSig="NA" /label="S999" downshifts 2416012 /Source="Nicolas_upshifts" /id="D1364" /incds=0 /nref=6 /ntot=135 /MaxReadThrough="2.57006" /MaxDrop="3.43983" /score="-6.36950065" /energy="-7" /TU="NA" /idTUdmin="U2050" /TUdmin=0 /isTUend="TRUE" CDS complement(2416076..2417113) /gene="yrdP" /locus_tag="BSU_26640" /old_locus_tag="BSU26640" /EC_number="1.14.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099864, 12100555, 12527699; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_390541.1" /db_xref="EnsemblGenomes-Gn:BSU26640" /db_xref="EnsemblGenomes-Tr:CAB14605" /db_xref="GOA:O07085" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR000960" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11980" /db_xref="UniProtKB/Swiss-Prot:O07085" /translation="MYDTIVIGAGQAGISIGYYLKQSDQKFIILDKSHEVGESWKDRY DSLVLFTSRMYSSLPGMHLEGEKHGFPSKNEIVAYLKKYVKKFEIPIQLRTEVISVLK IKNYFLIKTNREEYQTKNLVIATGPFHTPNIPSISKDLSDNINQLHSSQYKNSKQLAY GNVLVVGGGNSGAQIAVELSKERVTYLACSNKLVYFPLMIGKRSIFWWFDKLGVLHAS HTSIVGKFIQKKGDPVFGHELKHAIKQKEIILKKRVIAAKQNEIIFKDSSTLEVNNII WATGFRNPLCWINIKGVLDQEGRIIHHRGVSPVEGLYFIGLPWQHKRGSALLQGVGND AEYIVKQMNGE*" gene complement(2416076..2417113) /gene="yrdP" /locus_tag="BSU_26640" /old_locus_tag="BSU26640" downshifts complement(2416088) /Source="Nicolas_upshifts" /id="D1365" /incds=0 /nref=30 /ntot=134 /MaxReadThrough="2.50972" /MaxDrop="5.83595" /score="2.19797168" /energy="-12.5" /TU="NA" /idTUdmin="U2051" /TUdmin=0 /isTUend="TRUE" S_feature complement(2417114..2417200) /Source="Nicolas_S_feature" /locus_tag="new_2723805_2723891_c" /HighExp="LBGtran, dia5, Gly, Diami, LBGstat, M0t45, LBGexp, Lbtran, dia0, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.907, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1000" CDS complement(2417201..2418136) /gene="czcD" /locus_tag="BSU_26650" /old_locus_tag="BSU26650" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10735849, 12100555, 15849754, 15948947, 16850406, 22447126, 26787764, 27210016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 12100555, 15849754, 15948947, 16850406, 22447126, 26787764, 27210016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium/proton-divalent cation antiporter" /protein_id="NP_390542.1" /db_xref="EnsemblGenomes-Gn:BSU26650" /db_xref="EnsemblGenomes-Tr:CAB14606" /db_xref="GOA:O07084" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11931" /db_xref="UniProtKB/Swiss-Prot:O07084" /translation="MGHNHNEGANKKVLLISFIMITGYMIIEAIGGFLTNSLALLSDA GHMLSDSISLMVALIAFTLAEKKANHNKTFGYKRFEILAAVINGAALILISLYIIYEA IERFSNPPKVATTGMLTISIIGLVVNLLVAWIMMSGGDTKNNLNIRGAYLHVISDMLG SVGAILAAILIIFFGWGWADPLASIIVAILVLRSGYNVTKDSIHILMEGTPENIDVSD IIRTIEGTEGIQNIHDLHIWSITSGLNALSCHAVVDDQLTISESENILRKIEHELEHK GITHVTIQMETEAHNHDNAILCQPKMEKQRDHHHH*" gene complement(2417201..2418136) /gene="czcD" /locus_tag="BSU_26650" /old_locus_tag="BSU26650" promotor_-10 complement(2418171..2418190) /Source="Nicolas_upshift_promotors" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2418178) /Source="Nicolas_upshifts" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" S_feature complement(2418180..2418263) /Source="Nicolas_S_feature" /locus_tag="new_2724871_2724954_c" /HighExp="dia5, Gly, LBGtran, Diami, LBGstat, LBGexp, LoTm, dia0, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1001" promotor_-35 complement(2418205..2418212) /Source="Nicolas_upshift_promotors" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2418244..2418263) /Source="Nicolas_upshift_promotors" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2418263) /Source="Nicolas_upshifts" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" promotor_-35 complement(2418277..2418284) /Source="Nicolas_upshift_promotors" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2418398) /Source="Nicolas_upshifts" /id="D1366" /incds=0 /nref=1 /ntot=41 /MaxReadThrough="3.75163" /MaxDrop="3.57795" /score="38.5313506" /energy="-18.1" /TU="NA" /idTUdmin="U2051" /TUdmin="-2310" /isTUend="FALSE" CDS complement(2418423..2418812) /gene="yrdN" /locus_tag="BSU_26660" /old_locus_tag="BSU26660" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_390543.1" /db_xref="EnsemblGenomes-Gn:BSU26660" /db_xref="EnsemblGenomes-Tr:CAB14607" /db_xref="GOA:P94502" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG12287" /db_xref="UniProtKB/Swiss-Prot:P94502" /translation="MPLLRFDLIEGRDQSSLKKLLDVAHNVVVEAFDVPQQDRYQIVH EHPENHMIIEDTGLGFNRTKNLVVLSVTSKSRPEEKKQKFYRLLAERLESECGIASTD LIVSIVENDNADWSFGLGEAQFLTGKL*" gene complement(2418423..2418812) /gene="yrdN" /locus_tag="BSU_26660" /old_locus_tag="BSU26660" promotor_-35 2419060..2419067 /Source="Nicolas_upshift_promotors" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2419083..2419102 /Source="Nicolas_upshift_promotors" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2419092 /Source="Nicolas_upshifts" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" CDS 2419146..2420036 /gene="gltR" /locus_tag="BSU_26670" /old_locus_tag="BSU26670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023181, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023181, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_390544.2" /db_xref="EnsemblGenomes-Gn:BSU26670" /db_xref="EnsemblGenomes-Tr:CAB14608" /db_xref="GOA:P94501" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11942" /db_xref="UniProtKB/Swiss-Prot:P94501" /translation="MNIQLLQVFLTTAREGSISKAALTLNYAQSNVTNKIQQLENDLQ TKLFYRHSRGITLTPPGQILVSYSEKILHTIEEARAAMGESSAPSGPLRIGSMETTAA VWLPQLLAHYNNLYPNVDLNLVTGPTEQQIQAVLHYELNGAFISGPIEHPDLVQEKVL DEEMVLVTSASHPVISSIQDVQTQTMLVFRKGCSYRAKLNHILQEEGLLPIKLMEFGI LEAIIGCVSAGLGISLLPRSIIASHEKEGRIRSHTISDKYSFVSTMFIRRKDTLITPA LSAFLTHMRDHFQIKRPDQS*" gene 2419146..2420036 /gene="gltR" /locus_tag="BSU_26670" /old_locus_tag="BSU26670" promotor_-35 2419724..2419729 /Source="Nicolas_upshift_promotors" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2419745..2419763 /Source="Nicolas_upshift_promotors" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2419752 /Source="Nicolas_upshifts" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2420194..2420511) /gene="yrdK" /locus_tag="BSU_26680" /old_locus_tag="BSU26680" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390545.3" /db_xref="EnsemblGenomes-Gn:BSU26680" /db_xref="EnsemblGenomes-Tr:CAB14609" /db_xref="SubtiList:BG12286" /db_xref="UniProtKB/Swiss-Prot:P94500" /translation="MRLYTEYIPNKNKLINQQQYHSDLQDLLHQWILQLLQLDVLPLS NRKYQSSRCHPKSVGEYLIVVRAIDALGNSQPLTSRRNQVSRAMTFVQNSLNEENLHP NID*" gene complement(2420194..2420511) /gene="yrdK" /locus_tag="BSU_26680" /old_locus_tag="BSU26680" CDS complement(2420469..2421791) /gene="brnQ" /locus_tag="BSU_26690" /old_locus_tag="BSU26690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8544834, 9287000, 9531631, 15849754, 16850406, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8544834, 9287000, 9531631, 15849754, 16850406, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="low-affinity branched-chain amino acid transporter" /protein_id="NP_390546.1" /db_xref="EnsemblGenomes-Gn:BSU26690" /db_xref="EnsemblGenomes-Tr:CAB14610" /db_xref="GOA:P94499" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG11918" /db_xref="UniProtKB/Swiss-Prot:P94499" /translation="MSKKVSASYIIIIGLMLFALFFGAGNLIFPPMLGQLAGKNVWVA NAGFLVTGVGLPLLAITAFVFSGKQNLQSLASRVHPVFGIVFTTILYLAIGPFFAIPR SGNVSFEIGVKPFLSNDASPVSLIIFTILFFALACLLSLNPSKIIDIVGKFLTPIKLT FIGLLVAVALIRPIGTIQAPSKGYTSQAFFKGFQEGYLTLDALVAFVFGIIIVNALKE QGASTKKQLIVVCAKAAAIAAVLLAVMYTALSYMGASSVEELGILENGAEVLAKVSSY YFGSYGSILLGLMITVACLTTSVGLITACSSFFHELFPNISYKKIAVVLSVFSTLVAN IGLTQLIKVSMPVLLTMYPIAISLIFLTFLHSVFKGKTEVYQGSLLFAFIISLFDGLK AAGIKIEVVNRIFTQILPMYNIGLGWLIPAIAGGICGYILSIFRTKTS*" gene complement(2420469..2421791) /gene="brnQ" /locus_tag="BSU_26690" /old_locus_tag="BSU26690" CDS complement(2421956..2422288) /gene="azlD" /locus_tag="BSU_26700" /old_locus_tag="BSU26700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9287000, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287000, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid / methionine exporter" /protein_id="NP_390547.1" /db_xref="EnsemblGenomes-Gn:BSU26700" /db_xref="EnsemblGenomes-Tr:CAB14611" /db_xref="GOA:O07923" /db_xref="InterPro:IPR008407" /db_xref="SubtiList:BG11916" /db_xref="UniProtKB/Swiss-Prot:O07923" /translation="MTMTMTQQMITIAMVVLGTMLTRFLPFMIFPSGKPTPKYVQYLG KVLPSAVIGLLVIYCLKDVSLLSGSHGIPELVGAAAVVLLHLWKKNMLLSIAGGTVVY MVLVQLVF*" gene complement(2421956..2422288) /gene="azlD" /locus_tag="BSU_26700" /old_locus_tag="BSU26700" CDS complement(2422285..2423049) /gene="azlC" /locus_tag="BSU_26710" /old_locus_tag="BSU26710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9287000, 15849754, 16850406, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287000, 15849754, 16850406, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid / methionine exporter" /protein_id="NP_390548.1" /db_xref="EnsemblGenomes-Gn:BSU26710" /db_xref="EnsemblGenomes-Tr:CAB14612" /db_xref="GOA:O07942" /db_xref="InterPro:IPR004471" /db_xref="InterPro:IPR011606" /db_xref="SubtiList:BG11915" /db_xref="UniProtKB/Swiss-Prot:O07942" /translation="MNKNKESLHLSSPAINTHMNKRSQIWAAFRSAFPYTIPIFAGFL FLGIAYGIFMHSLGFSAIYPIIMSFMIFAGSMEFVAANFLLGAFNPMNALFLTLMVNA RHLFYGISMLDKYRGTGKKKLYLIFGMCDESFSINYTANVPANVDKGWFMFFVTLLNH LYWVAGAAIGGIFGSYVKFNTEGLDFVMTALFIVIFIEQWMKEKKHYSALTGLGLSVA SLILFGGNQFIIPAMLAILGVLTVLRKPLEKAEVSV*" gene complement(2422285..2423049) /gene="azlC" /locus_tag="BSU_26710" /old_locus_tag="BSU26710" CDS complement(2423062..2423535) /gene="azlB" /locus_tag="BSU_26720" /old_locus_tag="BSU26720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023181, 9287000, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023181, 9287000, 26473603; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the azlBCD operon" /protein_id="NP_390549.1" /db_xref="EnsemblGenomes-Gn:BSU26720" /db_xref="EnsemblGenomes-Tr:CAB14613" /db_xref="GOA:O07920" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11914" /db_xref="UniProtKB/Swiss-Prot:O07920" /translation="MGIMLDETDKAILRDLQEDASISNLNLSKKIGLSPSACLARTKN LVEAGIIKKFTTIVDEKKLGIEVTALALINLSPLNRETIHSFLEDINKFPQVQECYTL TGSHDYMLKIVAKDMESYRNFIIDSLMQNPAISGVDTSIVMSTEKRTVSVPIDEM*" gene complement(2423062..2423535) /gene="azlB" /locus_tag="BSU_26720" /old_locus_tag="BSU26720" CDS complement(2423869..2424144) /gene="yrdF" /locus_tag="BSU_26730" /old_locus_tag="BSU26730" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative ribonuclease inhibitor" /protein_id="NP_390550.1" /db_xref="EnsemblGenomes-Gn:BSU26730" /db_xref="EnsemblGenomes-Tr:CAB14614" /db_xref="GOA:O07938" /db_xref="InterPro:IPR000468" /db_xref="InterPro:IPR035905" /db_xref="SubtiList:BG12285" /db_xref="UniProtKB/Swiss-Prot:O07938" /translation="MRKIIIDGRDFENIEVLHDDLKDKLDFPDYYGRNLDALWDCLTG WVDLPLTLVLKNFEFSNTFLGSYADDVLEVIQEAQEELKDEFKIIIE*" gene complement(2423869..2424144) /gene="yrdF" /locus_tag="BSU_26730" /old_locus_tag="BSU26730" misc_feature complement(2424156..2424175) /Source="Nicolas_upshift_promotors" /id="U2055" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.972027972027972" /xcortree=3056 /SigmaFactorBS="ttttcagcctcatttggacaaacagctgttacatagtaaacg tttgtTAAGATAAAATAATGGAGGGcatagtttctaatgagaaaaataataatagatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2424162) /Source="Nicolas_upshifts" /id="U2055" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.972027972027972" /xcortree=3056 /SigmaFactorBS="ttttcagcctcatttggacaaacagctgttacatagtaaacg tttgtTAAGATAAAATAATGGAGGGcatagtttctaatgagaaaaataataatagatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2424230..2424415) /Source="Nicolas_S_feature" /locus_tag="new_2730921_2731106_c" /HighExp="BT, S4, S8, S3, S5, S7, S6, LoTm, B36, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S1002" CDS complement(2424416..2425648) /gene="cypA" /locus_tag="BSU_26740" /old_locus_tag="BSU26740" /EC_number="1.14.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9778370, 12354229, 28898812" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9778370, 12354229, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450" /protein_id="NP_390551.1" /db_xref="EnsemblGenomes-Gn:BSU26740" /db_xref="EnsemblGenomes-Tr:CAB14615" /db_xref="GOA:O08469" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG11929" /db_xref="UniProtKB/Swiss-Prot:O08469" /translation="MSSKEKKSVTILTESQLSSRAFKDEAYEFYKELRKSQALYPLSL GALGKGWLISRYDDAIHLLKNEKLKKNYENVFTAKEKRPALLKNEETLTKHMLNSDPP DHNRLRTLVQKAFTHRMILQLEDKIQHIADSLLDKVQPNKFMNLVDDYAFPLPIIVIS EMLGIPLEDRQKFRVWSQAIIDFSDAPERLQENDHLLGEFVEYLESLVRKKRREPAGD LISALIQAESEGTQLSTEELYSMIMLLIVAGHETTVNLITNMTYALMCHHDQLEKLRQ QPDLMNSAIEEALRFHSPVELTTIRWTAEPFILHGQEIKRKDVIIISLASANRDEKIF PNADIFDIERKNNRHIAFGHGNHFCLGAQLARLEAKIAISTLLRRCPNIQLKGEKKQM KWKGNFLMRALEELPISF*" gene complement(2424416..2425648) /gene="cypA" /locus_tag="BSU_26740" /old_locus_tag="BSU26740" CDS complement(2425698..2425856) /gene="yrdDc" /locus_tag="BSU_26748" /old_locus_tag="BSU26748" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; C-terminal part of YrdD" /db_xref="PSEUDO:CAX52669.1" /translation="MEVLGVSPFYQGKSLGSKMINDCLISFISKCGDGILALIMNTDL NGSFYKSS*" gene complement(2425698..2425856) /gene="yrdDc" /locus_tag="BSU_26748" /old_locus_tag="BSU26748" /pseudo CDS complement(2425853..2426056) /gene="yrdDm" /locus_tag="BSU_26749" /old_locus_tag="BSU26749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; internal part of YrdD" /db_xref="SubtiList:BG12284" /translation="MHKVLTRAYFKKHFFFVGIQNGEMVVAALLKHRDKPDIKLDRLY SSRGDNINQNGAKKFSKSLKEPA*" gene complement(2425853..2426056) /gene="yrdDm" /locus_tag="BSU_26749" /old_locus_tag="BSU26749" /pseudo promotor_-10 complement(2426017..2426035) /Source="Nicolas_upshift_promotors" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2426034) /Source="Nicolas_upshifts" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" CDS complement(2426041..2426190) /gene="yrdDn" /locus_tag="BSU_26750" /old_locus_tag="BSU26750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; N-terminal part of YrdD" /db_xref="SubtiList:BG14036" /translation="MFLYRQARADEVSKVAKLFHQSFNQYPFMDLLVKREKKIIHLFL KCIKY*" gene complement(2426041..2426190) /gene="yrdDn" /locus_tag="BSU_26750" /old_locus_tag="BSU26750" /pseudo promotor_-35 complement(2426050..2426055) /Source="Nicolas_upshift_promotors" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2426274) /Source="Nicolas_upshifts" /id="D1367" /incds=0 /nref=140 /ntot=216 /MaxReadThrough="2.2276" /MaxDrop="4.5127" /score="5.01317133" /energy="-16.7" /TU="NA" /idTUdmin="U2057" /TUdmin=0 /isTUend="TRUE" CDS complement(2426289..2426852) /gene="yrdC" /locus_tag="BSU_26760" /old_locus_tag="BSU26760" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390553.1" /db_xref="EnsemblGenomes-Gn:BSU26760" /db_xref="EnsemblGenomes-Tr:CAB14617" /db_xref="GOA:O07081" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12283" /db_xref="UniProtKB/Swiss-Prot:O07081" /translation="MEEKKALIIVDVQKAFDDKKWGERNNVKAEENISKILELWREKG WTVIYIQHTSDKPHSLFHPKNEGFAIKEIVKPMDEEVIITKTVNSSFIGTNLEEFLKL NEITTVVITGLTTPHCVSTTTRMSGNLGFDTYLISDATAAFGMRDQNDTYYDAATIHN ISLATLHDEFATILTTDQLINDFIKTH*" gene complement(2426289..2426852) /gene="yrdC" /locus_tag="BSU_26760" /old_locus_tag="BSU26760" downshifts 2426770 /Source="Nicolas_upshifts" /id="D1368" /incds=1 /nref=44 /ntot=194 /MaxReadThrough="1.72227" /MaxDrop="3.37915" /score="14.6499034" /energy="-6.6" /TU="NA" /idTUdmin="U2060" /TUdmin="-4488" /isTUend="FALSE" promotor_-10 complement(2426882..2426901) /Source="Nicolas_upshift_promotors" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2426890) /Source="Nicolas_upshifts" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" promotor_-35 complement(2426916..2426923) /Source="Nicolas_upshift_promotors" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2427081..2427452) /gene="yrdB" /locus_tag="BSU_26770" /old_locus_tag="BSU26770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390554.1" /db_xref="EnsemblGenomes-Gn:BSU26770" /db_xref="EnsemblGenomes-Tr:CAB14618" /db_xref="GOA:O07080" /db_xref="InterPro:IPR021214" /db_xref="SubtiList:BG12282" /db_xref="UniProtKB/Swiss-Prot:O07080" /translation="MEKLNQTNLLLRFTLEIAALISLGVYAWISFNGYFKYVLTLVLP IAVMIVWSVFAVPHDPSRSGQTVIAVNGVTRLVIELLIFAMAVAALYFSYLKPVSIVF LCLIILHYIISAERIKWLLNQ*" gene complement(2427081..2427452) /gene="yrdB" /locus_tag="BSU_26770" /old_locus_tag="BSU26770" S_feature complement(2427453..2427682) /Source="Nicolas_S_feature" /locus_tag="new_2734144_2734373_c" /HighExp="BMM, GM 120, GM 90, SMM, MG 150, GM 60, MG 120, M9-tran, Glu, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48162700000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1003" promotor_-10 complement(2427664..2427683) /Source="Nicolas_upshift_promotors" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="promotor_-10" upshifts complement(2427680) /Source="Nicolas_upshifts" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" promotor_-35 complement(2427697..2427704) /Source="Nicolas_upshift_promotors" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="promotor_-35" downshifts complement(2428248) /Source="Nicolas_upshifts" /id="D1369" /incds=0 /nref=174 /ntot=248 /MaxReadThrough="2.42722" /MaxDrop="5.81863" /score="7.90390368" /energy="-10.3" /TU="NA" /idTUdmin="U2059" /TUdmin=6 /isTUend="TRUE" CDS complement(2428262..2428765) /gene="yrdA" /locus_tag="BSU_26780" /old_locus_tag="BSU26780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390555.1" /db_xref="EnsemblGenomes-Gn:BSU26780" /db_xref="EnsemblGenomes-Tr:CAB14619" /db_xref="GOA:O07079" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12281" /db_xref="UniProtKB/Swiss-Prot:O07079" /translation="MFQTLDHFLKSWEFEADATQKLLNSLTDESLKQEITSQNWTLGR IAWHTVAAIGIITSNTDLTFQAPAEDYPVPTSAQFIADSYHQASNAFVQALKTQWTDH TLQERINFIGQQMPNGSLLMFLIQHQNHHRGQMTVLMRQAGLTVPGIYGPAKEEWAKF GLEAPKM*" gene complement(2428262..2428765) /gene="yrdA" /locus_tag="BSU_26780" /old_locus_tag="BSU26780" S_feature complement(2428766..2428990) /Source="Nicolas_S_feature" /locus_tag="new_2735457_2735681_c" /HighExp="Etha, Lbstat, M0t90, M40t90, LoTm, M9-stat, Gly, S2, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1004" CDS complement(2428991..2429845) /gene="aadK" /locus_tag="BSU_26790" /old_locus_tag="BSU26790" /EC_number="2.7.7.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8293959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8293959; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aminoglycoside 6-adenylyltransferase" /protein_id="NP_390556.1" /db_xref="EnsemblGenomes-Gn:BSU26790" /db_xref="EnsemblGenomes-Tr:CAB14620" /db_xref="GOA:P17585" /db_xref="InterPro:IPR007530" /db_xref="PDB:2PBE" /db_xref="SubtiList:BG11037" /db_xref="UniProtKB/Swiss-Prot:P17585" /translation="MRSEQEMMDIFLDFALNDERIRLVTLEGSRTNRNIPPDNFQDYD ISYFVTDVESFKENDQWLEIFGKRIMMQKPEDMELFPPELGNWFSYIILFEDGNKLDL TLIPIREAEDYFANNDGLVKVLLDKDSFINYKVTPNDRQYWIKRPTAREFDDCCNEFW MVSTYVVKGLARNEILFAIDHLNEIVRPNLLRMMAWHIASQKGYSFSMGKNYKFMKRY LSNKEWEELMSTYSVNGYQEMWKSLFTCYALFRKYSKAVSEGLAYKYPDYDEGITKYT EGIYCSVK*" gene complement(2428991..2429845) /gene="aadK" /locus_tag="BSU_26790" /old_locus_tag="BSU26790" S_feature complement(2429846..2429948) /Source="Nicolas_S_feature" /locus_tag="new_2736537_2736639_c" /HighExp="M9-stat, T3.0H, T0.30H, T1.30H, T2.30H, Lbtran, T3.30H, T1.0H, M0t90, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1005" promotor_-10 complement(2429929..2429948) /Source="Nicolas_upshift_promotors" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2429946) /Source="Nicolas_upshifts" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" promotor_-35 complement(2429963..2429966) /Source="Nicolas_upshift_promotors" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2430117..2430124 /Source="Nicolas_upshift_promotors" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2430138..2430157 /Source="Nicolas_upshift_promotors" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2430153 /Source="Nicolas_upshifts" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" S_feature 2430158..2430223 /Source="Nicolas_S_feature" /locus_tag="new_2736849_2736914" /HighExp="LoTm, BC, S1, S2, C90, T4.0H, HiOs, T5.0H, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.894" /TUlongSig="NA" /TUlongPSig="NA" /label="S1006" CDS 2430224..2431267 /gene="yrpB" /locus_tag="BSU_26800" /old_locus_tag="BSU26800" /EC_number="1.13.12.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9501443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative anionic nitroalkane monoxygenase" /protein_id="NP_390557.1" /db_xref="EnsemblGenomes-Gn:BSU26800" /db_xref="EnsemblGenomes-Tr:CAB14621" /db_xref="GOA:O05413" /db_xref="InterPro:IPR004136" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12305" /db_xref="UniProtKB/Swiss-Prot:O05413" /translation="MNEFMKKFSLTKPIIQAPMAGGITKPRLASAVSNQGALGSLASG YLTPDLLEQQIKEIFELTDAPFQINVFVPLGLEMPPKDQIKKWKENIPLANQVNQFTS VQEEWDDFYQKIDLILKYKVKACSFTFDLPPEDAVKELKTAGCCLIGTASTVEEALLM EERGMDIVVLQGSEAGGHRGAFLPSKGESAVGLMALIPQAADALSVPVIAAGGMIDHR GVKAALTLGAQGVQIGSAFLICHESNAHPVHKQKILEANEADTKLTTLFSGKEARGIV NKWMEENEQFETQTLPYPYQNTLTKAMRQKASLQNNHDQMSLWAGQGIRSLTEEISVK QLLNQLCQEDIKI*" gene 2430224..2431267 /gene="yrpB" /locus_tag="BSU_26800" /old_locus_tag="BSU26800" downshifts 2431265 /Source="Nicolas_upshifts" /id="D1370" /incds=0 /nref=22 /ntot=198 /MaxReadThrough="1.3622" /MaxDrop="5.04821" /score="14.6499034" /energy="-6.6" /TU="NA" /idTUdmin="U2060" /TUdmin=7 /isTUend="TRUE" promotor_-35 2431552..2431559 /Source="Nicolas_upshift_promotors" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="promotor_-35" upshifts 2431566 /Source="Nicolas_upshifts" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" promotor_-10 2431573..2431592 /Source="Nicolas_upshift_promotors" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="promotor_-10" CDS 2431617..2432414 /gene="murI" /locus_tag="BSU_26810" /old_locus_tag="BSU26810" /EC_number="5.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12829290, 15212785, 15347750, 17720142, 25777674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12829290, 15212785, 15347750, 17720142, 25777674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390558.1" /db_xref="EnsemblGenomes-Gn:BSU26810" /db_xref="EnsemblGenomes-Tr:CAB14622" /db_xref="GOA:O05412" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="SubtiList:BG12306" /db_xref="UniProtKB/Swiss-Prot:O05412" /translation="MKIGFFDSGIGGMTVLYEAIKVLPYEDYIFYADTLNVPYGEKSK GKVKEYIFNAAEFLASQNIKALVIACNTATSIAIEDLRRNFDFPIIGIEPAVKPAINK CTEERKRVLVVATNLTLKEEKFHNLVKEIDHHDLVDCLALPGLVEFAENFDFSEDKII KYLKNELSSFDLKQYGTIVLGCTHFPFFKNSFEKLFGIKVDMISGSVGTAKQLKKVLA DRNQLGKGSGSITFFNSGHKIVDQEVISKYKRLFEILDETQRSHVGH*" gene 2431617..2432414 /gene="murI" /locus_tag="BSU_26810" /old_locus_tag="BSU26810" promotor_-35 2432720..2432724 /Source="Nicolas_upshift_promotors" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2432738..2432757 /Source="Nicolas_upshift_promotors" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2432748 /Source="Nicolas_upshifts" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" promotor_-10 complement(2432772..2432786) /Source="Nicolas_upshift_promotors" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2432786) /Source="Nicolas_upshifts" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2432795..2432799) /Source="Nicolas_upshift_promotors" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2432795..2433502 /gene="yrpD" /locus_tag="BSU_26820" /old_locus_tag="BSU26820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390559.1" /db_xref="EnsemblGenomes-Gn:BSU26820" /db_xref="EnsemblGenomes-Tr:CAB14623" /db_xref="InterPro:IPR029143" /db_xref="SubtiList:BG12307" /db_xref="UniProtKB/Swiss-Prot:O05411" /translation="MMKKGLLAGALTATVLFGTCAVDVPGIISPKTAEAASQLTDGIG GRAYLNSNGAILVTKIQLPSSTQVSNGTAYIYSGFSGGTESDIGFQYSDKYNVWKPYM KVGSKGQDQVQYLEGGSQFTNTKGFRPGSTVQLTIYKNLNGNTRATYWGTNNAGYNGR LISEISKTNVGSISKWKALATVATTGSRQSIKSNFSTSFTNITIDNKAITPVIDTQDF AKVTVSGNSVSLSVVKN*" gene 2432795..2433502 /gene="yrpD" /locus_tag="BSU_26820" /old_locus_tag="BSU26820" downshifts 2433502 /Source="Nicolas_upshifts" /id="D1371" /incds=0 /nref=4 /ntot=168 /MaxReadThrough="5.98921" /MaxDrop="2.677" /score="15.7112026" /energy="-8.2" /TU="U2062" /idTUdmin="U2064" /TUdmin="-660" /isTUend="FALSE" S_feature 2433547..2433720 /Source="Nicolas_S_feature" /locus_tag="new_2740238_2740411" /HighExp="Lbstat, M0t90, M40t90, BT, S0, ferm, S2, M9-stat, Lbtran, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="SigA" /TUlongPSig=1 /label="S1007" promotor_-35 2433702..2433703 /Source="Nicolas_upshift_promotors" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2433719..2433738 /Source="Nicolas_upshift_promotors" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2433722..2434050 /Source="Nicolas_S_feature" /locus_tag="new_2740413_2740741" /HighExp="Lbstat, M0t90, BT, M40t90, S2, S0, ferm, T2.0H, M9-stat, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99711000000000005" /TUshortSig="SigA, SigA" /TUshortPSig="0.861, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1008" upshifts 2433722 /Source="Nicolas_upshifts" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" CDS 2433826..2433987 /locus_tag="BSU_26829" /old_locus_tag="BSU26829" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90581.1" /translation="MYFHKRGMASYSSIASGRLANDWPRTTHHFETDSFQNHKYDPIT NKDQLAVQP*" gene 2433826..2433987 /locus_tag="BSU_26829" /old_locus_tag="BSU26829" /pseudo promotor_-35 2434016..2434025 /Source="Nicolas_upshift_promotors" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2434038..2434057 /Source="Nicolas_upshift_promotors" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2434052..2434203 /Source="Nicolas_S_feature" /locus_tag="new_2740743_2740894" /HighExp="BT, S8, B36, S7, Lbstat, G/S, Pyr, M0t90, B60, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94474599999999997" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.861, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1009" upshifts 2434052 /Source="Nicolas_upshifts" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" CDS 2434078..2434155 /gene="yrpDX" /locus_tag="BSU_26826" /old_locus_tag="BSU26826" /experiment="publication(s) with functional evidences, PMID:20709900" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="expressed polypeptide of unknown function" /protein_id="YP_009513985.1" /db_xref="EnsemblGenomes-Gn:BSU26826" /db_xref="EnsemblGenomes-Tr:CCQ48602" /db_xref="GOA:L8E9J8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8E9J8" /translation="MRSFPLIVVLFILLIIVGTSFFGGY*" gene 2434078..2434155 /gene="yrpDX" /locus_tag="BSU_26826" /old_locus_tag="BSU26826" downshifts 2434160 /Source="Nicolas_upshifts" /id="D1372" /incds=0 /nref=23 /ntot=198 /MaxReadThrough="3.86249" /MaxDrop="4.0885" /score="28.4802594" /energy="-18.1" /TU="U2062,U2065" /idTUdmin="U2064" /TUdmin="-2" /isTUend="TRUE" S_feature 2434205..2434402 /Source="Nicolas_S_feature" /locus_tag="new_2740896_2741093" /HighExp="BT, B36, S8, Lbstat, G/S, Pyr, Diami, S7, dia15, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1010" S_feature complement(2434394..2434665) /Source="Nicolas_S_feature" /locus_tag="new_2741085_2741356_c" /HighExp="Heat, BMM, Etha, S2, S3, S4, B36, S5, B60, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40965600000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1011" downshifts complement(2434436) /Source="Nicolas_upshifts" /id="D1373" /incds=0 /nref=37 /ntot=78 /MaxReadThrough="2.30607" /MaxDrop="6.9537" /score="19.9821634" /energy="-15.5" /TU="NA" /idTUdmin="U2066" /TUdmin=0 /isTUend="TRUE" CDS complement(2434442..2434603) /locus_tag="BSU_26827" /old_locus_tag="BSU26827" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513986.1" /translation="MGKKLIETIQYPPYYCDVAYLESSHMKSRRNLFQNKKSLDVWQW ITLEIYWLI*" gene complement(2434442..2434603) /locus_tag="BSU_26827" /old_locus_tag="BSU26827" CDS complement(2434666..2435421) /gene="zinT" /locus_tag="BSU_26830" /old_locus_tag="BSU26830" /function="16.14: Store" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 24128931; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein buffering protein for Zn2+ transport" /protein_id="NP_390560.1" /db_xref="EnsemblGenomes-Gn:BSU26830" /db_xref="EnsemblGenomes-Tr:CAB14624" /db_xref="GOA:O05410" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015304" /db_xref="SubtiList:BG12308" /db_xref="UniProtKB/Swiss-Prot:O05410" /translation="MNILFSKRLGILTIGSLLVLAGCQTSGSSAGESNQTTSSSAVEE DSSKTQEQTSDSHTHEHSHDHSHAHDEETEKIYEGYFKNSQVKDRLLSDWEGDWQSVY PYLQDGTLDEVFSYKSEHEGGKTAEEYKEYYKKGYQTDVDRIVIQKDTVTFFKNGKEY SGKYTYDGYEILTYDAGNRGVRYIFKLAKKAEGLPQYIQFSDHSIYPTKASHYHLYWG DDREALLDEVKNWPTYYPSKMDGHDIAHEMMAH*" gene complement(2434666..2435421) /gene="zinT" /locus_tag="BSU_26830" /old_locus_tag="BSU26830" promotor_-10 complement(2435452..2435471) /Source="Nicolas_upshift_promotors" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2435468) /Source="Nicolas_upshifts" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" promotor_-35 complement(2435487..2435492) /Source="Nicolas_upshift_promotors" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2435553..2436083) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" gene complement(2435553..2436083) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" promotor_-10 complement(2436129..2436148) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2436152) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2436162..2436169) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2436218..2437198 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" gene 2436218..2437198 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" CDS complement(2437472..2438788) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" gene complement(2437472..2438788) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" S_feature complement(2438789..2438902) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2438903..2439772) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" gene complement(2438903..2439772) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" promotor_-10 complement(2439795..2439814) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2439812) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" promotor_-35 complement(2439829..2439834) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2439879..2439880) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2439887) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" promotor_-35 complement(2439917..2439918) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2439917..2441020 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" gene 2439917..2441020 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" misc_feature 2440910..2440929 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2440916 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts complement(2441267) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" CDS complement(2441293..2442126) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" gene complement(2441293..2442126) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" misc_feature complement(2442156..2442175) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2442165) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" promotor_-35 2442331..2442335 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2442346..2442568 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2442346 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" promotor_-10 2442350..2442369 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2442569..2442832 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" gene 2442569..2442832 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" downshifts 2442820 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" CDS 2442969..2443784 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" gene 2442969..2443784 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" S_feature complement(2444119..2444191) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2444162) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" CDS complement(2444192..2444548) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" gene complement(2444192..2444548) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" CDS complement(2444601..2444960) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" gene complement(2444601..2444960) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" misc_feature complement(2445053..2445072) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2445063) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" CDS complement(2445232..2445333) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" gene complement(2445232..2445333) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" S_feature complement(2445373..2445475) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2445415) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" CDS complement(2445476..2445862) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" gene complement(2445476..2445862) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" misc_feature complement(2445904..2445920) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2445920) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" promotor_-35 2446053..2446059 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2446074..2446085 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2446074 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" CDS 2446111..2446356 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" gene 2446111..2446356 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" CDS 2446374..2446742 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" gene 2446374..2446742 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" CDS 2446761..2447897 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" gene 2446761..2447897 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" CDS 2447916..2448113 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" gene 2447916..2448113 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" CDS 2448129..2448428 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" gene 2448129..2448428 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" downshifts 2448419 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" CDS complement(2448691..2449113) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" gene complement(2448691..2449113) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" promotor_-35 2449111..2449114 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2449130..2449149 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2449145..2449295 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2449145 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" promotor_-10 complement(2449148..2449167) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2449155) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" promotor_-35 complement(2449181..2449188) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2449264..2449283) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2449272) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" CDS 2449296..2449490 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" gene 2449296..2449490 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" promotor_-35 complement(2449298..2449305) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2449508..2449515 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2449531..2449550 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2449535 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" S_feature 2449536..2449620 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2449621..2450670 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" gene 2449621..2450670 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" promotor_-35 2450738..2450745 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2450760..2450779 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2450773 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" CDS 2450801..2451310 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" gene 2450801..2451310 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" downshifts 2451279 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" S_feature 2451324..2452429 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2451352..2453385) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" gene complement(2451352..2453385) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" downshifts complement(2451377) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" CDS complement(2453294..2453461) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" gene complement(2453294..2453461) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" S_feature complement(2453386..2453541) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2453542..2454369) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " gene complement(2453542..2454369) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" CDS complement(2454390..2455199) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" gene complement(2454390..2455199) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" CDS complement(2455216..2455704) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" gene complement(2455216..2455704) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" CDS complement(2455704..2456144) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" gene complement(2455704..2456144) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" downshifts 2456141 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" misc_feature complement(2456181..2456199) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2456185) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" CDS complement(2456334..2459141) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" gene complement(2456334..2459141) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" misc_feature complement(2459357..2459376) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2459363) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" CDS 2459688..2459828 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" gene 2459688..2459828 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" misc_feature 2459809..2459828 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2459819 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" CDS 2459867..2461255 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" gene 2459867..2461255 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" downshifts 2461244 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" S_feature complement(2461277..2461350) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2461319) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" CDS complement(2461351..2461983) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" gene complement(2461351..2461983) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" downshifts complement(2461407) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(2462037..2462056) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2462048) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" promotor_-35 2462062..2462068 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2462071..2462078) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2462082..2462101 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2462087 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" CDS 2462136..2462963 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " gene 2462136..2462963 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" downshifts 2462959 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" promotor_-35 2463076..2463085 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2463098..2463113 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2463103 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" CDS 2463159..2463659 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" gene 2463159..2463659 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" CDS 2463659..2464516 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" gene 2463659..2464516 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" promotor_-10 complement(2464534..2464545) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2464553) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2464560..2464566) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2464627..2466531 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" gene 2464627..2466531 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" promotor_-35 2466612..2466618 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2466634..2466652 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2466640 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" CDS 2466665..2466955 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" gene 2466665..2466955 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" S_feature 2466956..2467071 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2467053..2467060 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2467073..2467198 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2467073 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" promotor_-10 2467074..2467092 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2467092..2467192 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" gene 2467092..2467192 /gene="surF" /locus_tag="BSU_misc_RNA_82" downshifts 2467155 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" CDS complement(2467199..2470363) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" gene complement(2467199..2470363) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" downshifts complement(2467215) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" promotor_-35 2468349..2468358 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2468372..2468391 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2468393 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2470379..2470963) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" gene complement(2470379..2470963) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" CDS complement(2471186..2471728) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" gene complement(2471186..2471728) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" S_feature complement(2471729..2471814) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2471812..2471827) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2471814) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" promotor_-35 complement(2471840..2471849) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2471883..2472099) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2471917..2472075) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" gene complement(2471917..2472075) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" downshifts complement(2471926) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" promotor_-10 complement(2472097..2472116) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2472099) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" S_feature complement(2472101..2472231) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2472130..2472139) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2472232..2472381) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" gene complement(2472232..2472381) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" downshifts 2472375 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" S_feature complement(2472382..2472472) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2472474..2472693) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2472517) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" downshifts 2472639 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" promotor_-10 complement(2472672..2472691) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2472693) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" S_feature complement(2472695..2472770) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2472706..2472713) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2472771..2473571) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" gene complement(2472771..2473571) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" S_feature complement(2473640..2473793) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2473683) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" promotor_-10 complement(2473784..2473803) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2473793) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" promotor_-35 complement(2473818..2473824) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2473834..2474202) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" gene complement(2473834..2474202) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" S_feature complement(2474203..2474299) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2474285..2474304) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2474289..2474292 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2474305) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" promotor_-10 2474308..2474327 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2474310 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" S_feature 2474311..2474517 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2474320..2474324) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2474518..2477460 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" gene 2474518..2477460 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" CDS 2477479..2477961 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" gene 2477479..2477961 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" downshifts 2477941 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" CDS complement(2477997..2478227) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" gene complement(2477997..2478227) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" downshifts complement(2478017) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" S_feature complement(2478228..2478309) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2478310..2479449) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" gene complement(2478310..2479449) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" CDS complement(2479451..2480374) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" gene complement(2479451..2480374) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" downshifts complement(2480367) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" S_feature complement(2480375..2480438) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2480439..2481134) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" gene complement(2480439..2481134) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" promotor_-10 complement(2480874..2480893) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2480892) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" promotor_-35 complement(2480906..2480915) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2481155..2481796) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" gene complement(2481155..2481796) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" promotor_-10 complement(2481363..2481382) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2481382) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" promotor_-35 complement(2481399..2481402) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2481848..2481857 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2481854..2481873) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2481860) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" promotor_-10 2481870..2481889 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2481879..2481943 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2481879 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" promotor_-35 complement(2481889..2481892) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2481924..2481931 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2481945 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" promotor_-10 2481947..2481964 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2481989..2482192 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" gene 2481989..2482192 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" downshifts 2482199 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" CDS complement(2482229..2482930) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" gene complement(2482229..2482930) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" downshifts complement(2482241) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" CDS complement(2482995..2484749) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" gene complement(2482995..2484749) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" misc_feature complement(2483023..2483042) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2483033) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" promotor_-10 complement(2484064..2484079) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2484067) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" promotor_-35 complement(2484092..2484101) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2484295..2484313) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2484309) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" promotor_-35 2484328..2484335 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2484328..2484333) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2484350..2484369 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2484355 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2484803..2485276) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" gene complement(2484803..2485276) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" downshifts complement(2484810) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" S_feature complement(2485277..2485409) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2485391..2485410) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2485409) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" S_feature complement(2485411..2485519) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2485424..2485431) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2485512..2485531) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2485519) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" CDS complement(2485527..2486162) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" gene complement(2485527..2486162) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" promotor_-35 complement(2485547..2485551) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2485657..2485662 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2485678..2485696 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2485685 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2486169..2487437) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" gene complement(2486169..2487437) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" CDS complement(2487456..2488385) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" gene complement(2487456..2488385) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" CDS complement(2488391..2489044) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " gene complement(2488391..2489044) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" S_feature complement(2489045..2489149) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2489131..2489150) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2489149) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" promotor_-35 complement(2489166..2489170) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2489196..2490278) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" gene complement(2489196..2490278) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" downshifts complement(2489230) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" promotor_-10 complement(2490294..2490313) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2490314) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" promotor_-35 complement(2490328..2490331) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2490404) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" CDS complement(2490409..2490690) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" gene complement(2490409..2490690) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" downshifts complement(2490469) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" CDS complement(2490708..2491124) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" gene complement(2490708..2491124) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" promotor_-10 complement(2490956..2490974) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2490975) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" promotor_-35 complement(2490990..2490995) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2491132..2491398) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" gene complement(2491132..2491398) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" promotor_-35 2491286..2491294 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2491309..2491328 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2491317..2492506 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2491317 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" S_feature complement(2491399..2491459) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2491453..2491472) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2491459) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" CDS complement(2491483..2494119) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" gene complement(2491483..2494119) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" promotor_-35 complement(2491486..2491493) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2493885..2493903) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2493901) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" promotor_-35 complement(2493917..2493924) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2494120..2494198) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2494199..2494406) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene complement(2494199..2494406) /gene="tboA" /locus_tag="BSU_misc_RNA_40" promotor_-10 complement(2494414..2494433) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2494429) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" promotor_-35 complement(2494448..2494455) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2494450..2495511) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" gene complement(2494450..2495511) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" promotor_-35 2495420..2495425 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2495431..2495666 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2495432 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" promotor_-10 2495441..2495459 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2495528..2495539) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2495529) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" promotor_-35 complement(2495553..2495559) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2495667..2496395 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" gene 2495667..2496395 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" downshifts complement(2496123) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" CDS 2496417..2497238 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" gene 2496417..2497238 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" CDS 2497299..2497949 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" gene 2497299..2497949 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" CDS 2497966..2498622 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" gene 2497966..2498622 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" downshifts 2498621 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" CDS complement(2498657..2498788) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " gene complement(2498657..2498788) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" downshifts complement(2498675) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" CDS complement(2498810..2499001) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" gene complement(2498810..2499001) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" CDS complement(2499013..2499537) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" gene complement(2499013..2499537) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" upshifts complement(2499124) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" promotor_-10 complement(2499128..2499139) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2499154..2499160) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2499508..2499519) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2499514) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" promotor_-35 complement(2499534..2499540) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2499595..2501991) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" gene complement(2499595..2501991) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" downshifts complement(2499621) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" promotor_-35 2499841..2499847 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2499855 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" promotor_-10 2499862..2499873 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2499875..2500224 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2499976) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" CDS complement(2502016..2502636) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" gene complement(2502016..2502636) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" CDS complement(2502722..2503837) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" gene complement(2502722..2503837) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" downshifts complement(2502723) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" CDS complement(2503868..2505007) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" gene complement(2503868..2505007) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" promotor_-10 complement(2504574..2504593) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2504586) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" promotor_-35 complement(2504607..2504614) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2505026..2505442) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" gene complement(2505026..2505442) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" S_feature complement(2505443..2505540) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2505525..2505544) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2505540) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" promotor_-35 complement(2505560..2505563) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2505588..2505595 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2505609..2505628 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2505617 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" CDS 2505645..2506910 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" gene 2505645..2506910 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" downshifts 2506909 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" CDS complement(2506952..2507716) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" gene complement(2506952..2507716) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" downshifts complement(2506970) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" misc_RNA complement(2507800..2508000) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" gene complement(2507800..2508000) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" downshifts complement(2507818) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" upshifts 2507987 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 2507988..2507997 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2507998..2508017) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2508009) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" promotor_-35 complement(2508030..2508037) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2508052..2509830) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" gene complement(2508052..2509830) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" CDS complement(2509844..2511118) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" gene complement(2509844..2511118) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" misc_RNA complement(2511208..2511440) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" gene complement(2511208..2511440) /gene="tboH" /locus_tag="BSU_misc_RNA_42" downshifts complement(2511238) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" promotor_-35 2511450..2511453 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2511464..2511483) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2511468..2511487 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2511470..2511754 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2511470 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" upshifts complement(2511483) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" promotor_-35 complement(2511498..2511505) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2511500..2511670) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" gene complement(2511500..2511670) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" promotor_-10 complement(2511701..2511712) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2511718) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" promotor_-35 complement(2511727..2511733) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2511730..2511737 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2511751..2511769 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2511756 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" CDS 2511803..2513359 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" gene 2511803..2513359 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" downshifts 2513338 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" CDS complement(2513386..2513784) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" gene complement(2513386..2513784) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" downshifts complement(2513394) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" CDS complement(2513838..2516042) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" gene complement(2513838..2516042) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" promotor_-10 complement(2516071..2516090) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2516078) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" S_feature complement(2516080..2516170) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2516105..2516112) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2516134 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" CDS complement(2516210..2516722) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" gene complement(2516210..2516722) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" downshifts complement(2516215) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" CDS complement(2516728..2519088) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" gene complement(2516728..2519088) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" promotor_-10 complement(2517192..2517211) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2517200) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" promotor_-35 complement(2517225..2517234) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2519102..2519121) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2519113) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" promotor_-35 complement(2519136..2519142) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2519155..2519478) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" gene complement(2519155..2519478) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" promotor_-10 complement(2519499..2519517) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2519510) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" promotor_-35 complement(2519532..2519538) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2519554..2520051) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" gene complement(2519554..2520051) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" S_feature complement(2520052..2520127) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2520121..2520140) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2520127) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" promotor_-35 complement(2520154..2520161) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2520209..2522422) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" gene complement(2520209..2522422) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" downshifts complement(2520214) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" promotor_-35 2521981..2521986 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2522000..2522019 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2522008 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2522461..2522757) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" gene complement(2522461..2522757) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" downshifts 2522668 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" S_feature complement(2522758..2522836) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2522798..2522803 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2522820..2522838 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2522822..2522841) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2522822 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" upshifts complement(2522836) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" S_feature complement(2522838..2523756) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2522856..2522859) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2522873..2524429 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" gene 2522873..2524429 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" promotor_-10 complement(2523742..2523760) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2523756) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" promotor_-35 complement(2523772..2523780) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2524430..2525194 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2524433..2525089) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" gene complement(2524433..2525089) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" promotor_-10 complement(2525108..2525119) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2525120) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" promotor_-35 complement(2525133..2525139) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2525172..2525177 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2525193..2525211 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2525196 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" CDS 2525224..2525676 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" gene 2525224..2525676 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" downshifts 2525660 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" downshifts complement(2525715) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" CDS complement(2525733..2525999) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" gene complement(2525733..2525999) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" CDS complement(2526036..2527181) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" gene complement(2526036..2527181) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" upshifts complement(2526088) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" misc_feature complement(2526091) /Source="Nicolas_upshift_promotors" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2526132) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" promotor_-10 complement(2526134..2526153) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2526168..2526173) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2527208..2528236) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" gene complement(2527208..2528236) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" CDS complement(2528266..2528466) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" gene complement(2528266..2528466) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" CDS complement(2528459..2529463) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" gene complement(2528459..2529463) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" CDS complement(2529474..2530079) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" gene complement(2529474..2530079) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" promotor_-10 complement(2530098..2530117) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2530114) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" S_feature complement(2530116..2530217) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2530128..2530134) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2530218..2530730) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" gene complement(2530218..2530730) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" promotor_-10 complement(2530759..2530770) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2530774) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" CDS complement(2530778..2532085) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" gene complement(2530778..2532085) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" promotor_-35 complement(2530785..2530791) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2532039) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" promotor_-10 complement(2532109..2532127) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2532124) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" promotor_-35 complement(2532142..2532148) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2532156..2533181) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" gene complement(2532156..2533181) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" promotor_-10 complement(2533218..2533237) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2533238) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" promotor_-35 complement(2533252..2533259) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2533307..2533314 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2533328..2533347 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2533336 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" promotor_-35 2533368..2533373 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2533382 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" promotor_-10 2533389..2533407 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2533419..2534066 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" gene 2533419..2534066 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" S_feature complement(2533741..2534074) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2534045 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" S_feature complement(2534076..2534273) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2534112..2534234) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" gene complement(2534112..2534234) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" downshifts complement(2534119) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" upshifts complement(2534282) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" promotor_-10 complement(2534283..2534300) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2534307..2534314) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2534319..2534609 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" gene 2534319..2534609 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" misc_feature 2534330..2534349 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2534330..2534477 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2534330 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" CDS 2534616..2534756 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" gene 2534616..2534756 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" downshifts 2534745 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" promotor_-35 2534805..2534811 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2534819..2534919 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2534826..2534844 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2534827 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" upshifts 2534879 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" CDS 2534920..2536374 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" gene 2534920..2536374 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" downshifts 2536375 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" CDS complement(2536415..2537137) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" gene complement(2536415..2537137) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" S_feature 2536420..2536841 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2536431) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" promotor_-10 complement(2537160..2537179) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2537177) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" promotor_-35 complement(2537193..2537200) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2537240..2537836) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" gene complement(2537240..2537836) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" downshifts complement(2537255) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" promotor_-10 complement(2537879..2537890) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2537881) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" S_feature complement(2537883..2537947) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2537905..2537911) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2537984..2539147) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" gene complement(2537984..2539147) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" downshifts complement(2537992) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" S_feature complement(2539148..2539223) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2539199..2539217) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2539223) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" promotor_-35 complement(2539233..2539238) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2539264..2540370) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" gene complement(2539264..2540370) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" promotor_-10 complement(2539946..2539964) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2539971) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" promotor_-35 complement(2539980..2539985) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2540282 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 2540283..2540286 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2540357..2541226) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" gene complement(2540357..2541226) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" downshifts 2540451 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" CDS complement(2541180..2542775) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" gene complement(2541180..2542775) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" promotor_-10 complement(2542803..2542822) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2542803..2542810 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2542824 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" promotor_-10 2542826..2542845 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2542827) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" promotor_-35 complement(2542837..2542844) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2542878..2544065 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" gene 2542878..2544065 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" promotor_-10 complement(2542879..2542898) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2542897) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2542913..2542922) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2543780..2543785 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2543794 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" promotor_-10 2543796..2543815 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2544025..2544567 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" gene 2544025..2544567 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" downshifts 2544550 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" CDS complement(2544592..2545449) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" gene complement(2544592..2545449) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" S_feature 2544595..2545304 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2544612) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" CDS complement(2545466..2545909) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" gene complement(2545466..2545909) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" CDS complement(2545970..2547256) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" gene complement(2545970..2547256) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" CDS complement(2547290..2547868) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" gene complement(2547290..2547868) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" S_feature complement(2547869..2547934) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2547919..2547938) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2547934) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" S_feature complement(2547936..2548153) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2547946..2548068 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" gene 2547946..2548068 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" promotor_-35 complement(2547952..2547959) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2548189..2548473) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" gene complement(2548189..2548473) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" downshifts complement(2548198) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" CDS complement(2548486..2548824) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" gene complement(2548486..2548824) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" CDS complement(2548827..2549135) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" gene complement(2548827..2549135) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" misc_RNA complement(2549149..2549224) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" gene complement(2549149..2549224) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" promotor_-10 complement(2549236..2549255) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2549256) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" promotor_-35 complement(2549269..2549276) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2549282..2550148) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" gene complement(2549282..2550148) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" CDS complement(2550141..2550935) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" gene complement(2550141..2550935) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" downshifts 2550938 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" promotor_no_box 2550944..2551044 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2550959..2550977) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2550970) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" promotor_-35 complement(2550993..2550998) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2551004 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2551047 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" downshifts complement(2551082) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" CDS complement(2551085..2551891) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" gene complement(2551085..2551891) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" CDS complement(2551893..2552573) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" gene complement(2551893..2552573) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" CDS complement(2552626..2553144) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" gene complement(2552626..2553144) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" CDS complement(2553141..2554013) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" gene complement(2553141..2554013) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" CDS complement(2554044..2555057) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" gene complement(2554044..2555057) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" upshifts complement(2555098) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" misc_feature complement(2555110..2555128) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2555149..2555844) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" gene complement(2555149..2555844) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" CDS complement(2555881..2556450) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" gene complement(2555881..2556450) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" promotor_-10 complement(2556302..2556317) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2556311) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" promotor_-35 complement(2556330..2556339) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2556489..2556508) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2556505) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" promotor_-35 complement(2556522..2556528) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2556601) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" CDS complement(2556603..2557601) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" gene complement(2556603..2557601) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" promotor_-10 complement(2557648..2557667) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2557656) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" promotor_-35 complement(2557679..2557686) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2557724) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" CDS complement(2557735..2558481) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" gene complement(2557735..2558481) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" promotor_-10 complement(2558509..2558528) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2558516) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" promotor_-35 complement(2558543..2558550) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2558621..2559913) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" gene complement(2558621..2559913) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" downshifts complement(2558626) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" S_feature complement(2559914..2559972) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2559973..2562615) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" gene complement(2559973..2562615) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" S_feature complement(2562616..2562674) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2562675..2562897) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene complement(2562675..2562897) /gene="tboV" /locus_tag="BSU_misc_RNA_44" downshifts complement(2562718) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" promotor_-10 complement(2562926..2562945) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2562938) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" S_feature complement(2562940..2563048) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2562960..2562965) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2563002..2563011 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2563024..2563043 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2563025 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" promotor_-10 complement(2563041..2563055) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2563048) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" promotor_-35 complement(2563063..2563067) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2563063..2563254 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" gene 2563063..2563254 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" CDS complement(2563273..2564298) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" gene complement(2563273..2564298) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" downshifts complement(2563303) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" CDS complement(2564331..2566058) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" gene complement(2564331..2566058) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" promotor_-35 2565660..2565663 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2565679..2565698 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2565685 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 2566054..2566058 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2566067..2566081 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2566081 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2566096..2566114) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2566112) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" promotor_-35 complement(2566130..2566135) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2566189..2567481) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" gene complement(2566189..2567481) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" downshifts complement(2566206) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" CDS complement(2567511..2568485) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" gene complement(2567511..2568485) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" CDS complement(2568482..2569270) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" gene complement(2568482..2569270) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" CDS complement(2569260..2570204) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" gene complement(2569260..2570204) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" CDS complement(2570237..2571067) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" gene complement(2570237..2571067) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" CDS complement(2571075..2572442) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" gene complement(2571075..2572442) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" misc_feature complement(2572506..2572525) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2572512) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" S_feature complement(2572514..2572603) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2572563..2572582 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2572571 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2572600..2572619) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2572603) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" S_feature complement(2572605..2573021) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2572630..2572638) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2572672..2573169 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" gene 2572672..2573169 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" promotor_-10 complement(2573005..2573023) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2573021) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" S_feature complement(2573023..2573153) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2573039..2573045) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2573133..2573144) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2573153) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" promotor_-35 complement(2573159..2573165) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2573191..2573778) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" gene complement(2573191..2573778) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" downshifts complement(2573219) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" CDS complement(2573775..2576099) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" gene complement(2573775..2576099) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" S_feature complement(2576100..2576211) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2576196..2576215) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2576211) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" promotor_-35 complement(2576229..2576236) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2576280..2577938) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" gene complement(2576280..2577938) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" downshifts complement(2576299) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2577982..2578000) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2577993) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" promotor_-35 complement(2578016..2578021) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2578090..2579352) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" gene complement(2578090..2579352) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" downshifts complement(2578100) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" S_feature complement(2579353..2579442) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2579430..2579449) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2579442) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" S_feature complement(2579444..2579575) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2579461..2579468) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2579620) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" CDS complement(2579624..2580898) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" gene complement(2579624..2580898) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" S_feature complement(2580899..2581088) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2581075..2581094) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2581088) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" promotor_-35 complement(2581109..2581113) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2581126..2582130) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" gene complement(2581126..2582130) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" promotor_-10 complement(2582155..2582174) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2582173) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" promotor_-35 complement(2582186..2582193) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2582249..2582848) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" gene complement(2582249..2582848) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" downshifts complement(2582270) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" CDS complement(2582861..2584279) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" gene complement(2582861..2584279) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" promotor_-35 2584168..2584172 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2584187..2584191 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2584187 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2584329..2585426) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" gene complement(2584329..2585426) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" CDS complement(2585447..2587003) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" gene complement(2585447..2587003) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" promotor_-35 2585843..2585846 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2585859..2588300 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2585859 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" promotor_-10 2585861..2585880 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2586990..2588018) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" gene complement(2586990..2588018) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" CDS complement(2588042..2588560) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" gene complement(2588042..2588560) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" promotor_-35 2588281..2588284 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2588300..2588304 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2588302 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2588557..2590281) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" gene complement(2588557..2590281) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" S_feature complement(2590282..2590402) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2590403..2590649) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene complement(2590403..2590649) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" downshifts complement(2590446) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" S_feature complement(2590650..2590776) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2590758..2590777) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2590776) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" S_feature complement(2590778..2590908) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2590792..2590799) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2590903..2590922) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2590912) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" promotor_-35 complement(2590936..2590939) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2591034..2591043 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2591057..2591076 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2591059 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" CDS 2591097..2591432 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" gene 2591097..2591432 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" downshifts 2591426 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" promotor_-35 2591513..2591520 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2591534..2591553 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2591536..2591600 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2591536 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" CDS 2591601..2592056 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" gene 2591601..2592056 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" promotor_-35 2592164..2592170 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2592184..2592202 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2592191 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" CDS 2592240..2593061 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" gene 2592240..2593061 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" downshifts 2593054 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" downshifts 2593118 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" tRNA complement(2593125..2593198) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2593125..2593198) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" downshifts complement(2593159) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" promotor_-10 complement(2593235..2593254) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2593238) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" promotor_-35 complement(2593268..2593275) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2593329..2593838) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" gene complement(2593329..2593838) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" downshifts complement(2593346) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" CDS complement(2593854..2594450) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" gene complement(2593854..2594450) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" CDS complement(2594463..2595200) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" gene complement(2594463..2595200) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" promotor_-10 complement(2595282..2595301) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2595298) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" CDS complement(2595311..2596411) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" gene complement(2595311..2596411) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" promotor_-35 complement(2595316..2595321) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2595328) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" promotor_-10 complement(2596434..2596452) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2596450) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" promotor_-35 complement(2596467..2596472) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2596526..2597344) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" gene complement(2596526..2597344) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" downshifts complement(2596538) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" CDS complement(2597352..2597792) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" gene complement(2597352..2597792) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" promotor_-10 complement(2597835..2597854) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2597844) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" S_feature complement(2597846..2597988) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2597870..2597874) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2598033) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" CDS complement(2598036..2598260) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" gene complement(2598036..2598260) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" upshifts 2598309 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 2598311..2598329 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2598318..2598337) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2598338) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" promotor_-35 complement(2598351..2598360) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2598376..2598819) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" gene complement(2598376..2598819) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" CDS complement(2598880..2599641) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" gene complement(2598880..2599641) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" downshifts complement(2598888) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" CDS complement(2599644..2601404) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" gene complement(2599644..2601404) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" CDS complement(2601438..2602046) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" gene complement(2601438..2602046) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" promotor_-35 2601816..2601823 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2601836..2601855 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2601838 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2602047..2602142) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2602132..2602151) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2602142) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" S_feature complement(2602144..2602765) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2602166..2602173) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2602281..2602285 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2602295..2602395 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2602302..2602321 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2602311 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" CDS 2602339..2602785 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" gene 2602339..2602785 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" upshifts 2602355 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" downshifts 2602773 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" downshifts complement(2602811) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" CDS complement(2602829..2604055) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" CDS complement(2602829..2603320) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" gene complement(2602829..2604055) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" gene complement(2602829..2603320) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" downshifts complement(2604169) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" misc_RNA complement(2604181..2604360) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" gene complement(2604181..2604360) /gene="kswC" /locus_tag="BSU_misc_RNA_46" downshifts complement(2604213) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2604385..2604404) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2604392) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" promotor_-35 complement(2604417..2604424) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2604425..2606197) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" gene complement(2604425..2606197) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" promotor_-10 complement(2606224..2606243) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2606238) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" promotor_-35 complement(2606257..2606264) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2606327) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" CDS complement(2606333..2606647) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" gene complement(2606333..2606647) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" promotor_-10 complement(2606673..2606692) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2606687) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" S_feature complement(2606689..2606898) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2606708..2606710) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2606792..2606902) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" gene complement(2606792..2606902) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo promotor_-10 complement(2606888..2606906) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2606898) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" promotor_-35 complement(2606921..2606927) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2606970..2608457) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" gene complement(2606970..2608457) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" S_feature complement(2608458..2608570) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2608551..2608570) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2608570) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" promotor_-35 complement(2608585..2608592) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2608674..2609651) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" gene complement(2608674..2609651) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" downshifts complement(2608682) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" CDS complement(2609687..2610460) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" gene complement(2609687..2610460) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" CDS complement(2610475..2611251) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" gene complement(2610475..2611251) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" downshifts 2610540 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" CDS complement(2611266..2611850) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" gene complement(2611266..2611850) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" promotor_-10 complement(2611892..2611911) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2611892) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" promotor_-35 complement(2611924..2611931) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2611955..2613637) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" gene complement(2611955..2613637) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" misc_feature complement(2613666..2613685) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2613674) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" downshifts complement(2613762) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" CDS complement(2613826..2614230) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" gene complement(2613826..2614230) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" downshifts complement(2613828) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" CDS complement(2614245..2616602) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" gene complement(2614245..2616602) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" CDS complement(2616623..2618335) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" gene complement(2616623..2618335) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" S_feature complement(2618336..2618408) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2618409..2618942) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" gene complement(2618409..2618942) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" CDS complement(2618949..2619206) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" gene complement(2618949..2619206) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" promotor_-10 complement(2619233..2619252) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2619249) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" promotor_-35 complement(2619264..2619271) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2619289..2619308 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2619296 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" CDS 2619340..2620281 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" gene 2619340..2620281 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" promotor_-10 complement(2620013..2620032) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2620028) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2620046..2620053) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2620264 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" downshifts complement(2620296) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" CDS complement(2620317..2622731) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" gene complement(2620317..2622731) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" downshifts complement(2620340) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" CDS complement(2622747..2623781) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" gene complement(2622747..2623781) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" S_feature complement(2623782..2624102) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2623863..2624069 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" gene 2623863..2624069 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" S_feature 2624092..2624356 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2624092 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" promotor_-10 complement(2624097..2624116) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2624099..2624113 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2624102) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" promotor_-35 complement(2624131..2624134) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2624136..2624882) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" gene complement(2624136..2624882) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" promotor_-10 complement(2624909..2624928) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2624915..2624921 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2624922) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" promotor_-10 2624935..2624946 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2624942..2624948) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2624949 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" CDS 2625001..2625216 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" gene 2625001..2625216 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" S_feature complement(2625198..2626610) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2625227..2625234 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2625250..2625269 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2625258 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" CDS 2625285..2626391 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" gene 2625285..2626391 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" promotor_-35 2626427..2626430 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2626446..2626465 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2626450 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" CDS 2626494..2627906 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" gene 2626494..2627906 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" promotor_-10 complement(2626596..2626615) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2626610) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" promotor_-35 complement(2626628..2626637) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2627903..2629237 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" gene 2627903..2629237 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" downshifts 2629235 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" downshifts complement(2629274) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" CDS complement(2629276..2629518) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" gene complement(2629276..2629518) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" S_feature complement(2629519..2629690) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2629578..2629748) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" gene complement(2629578..2629748) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" CDS complement(2629691..2631487) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" gene complement(2629691..2631487) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" promotor_-10 complement(2629793..2629811) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2629811) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" promotor_-35 complement(2629823..2629831) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2631484 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" promotor_-10 complement(2631512..2631531) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2631522) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" promotor_-35 complement(2631546..2631552) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2631582..2631638) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2631606) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" CDS complement(2631639..2633141) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" gene complement(2631639..2633141) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" downshifts complement(2633012) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" promotor_no_box complement(2633116..2633216) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2633156) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" CDS complement(2633160..2634005) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" gene complement(2633160..2634005) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" CDS complement(2634006..2634947) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" gene complement(2634006..2634947) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" CDS complement(2634983..2636284) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" gene complement(2634983..2636284) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" CDS complement(2636315..2637499) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" gene complement(2636315..2637499) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" CDS complement(2637496..2638314) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" gene complement(2637496..2638314) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" CDS complement(2638292..2638981) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" gene complement(2638292..2638981) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" CDS complement(2638998..2640680) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" gene complement(2638998..2640680) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" CDS complement(2640694..2642184) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" gene complement(2640694..2642184) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" promotor_-10 complement(2642277..2642296) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2642284) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" S_feature complement(2642286..2642361) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2642311..2642318) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2642362..2643333) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" gene complement(2642362..2643333) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" S_feature complement(2643334..2643462) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2643447..2643466) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2643462) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" promotor_-35 complement(2643481..2643484) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2643530..2644615) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" gene complement(2643530..2644615) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" downshifts complement(2643544) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(2644641..2644660) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2644664) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" promotor_-35 complement(2644675..2644682) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2644733..2644742 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2644748 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" promotor_-10 2644754..2644769 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2644799..2645191 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" gene 2644799..2645191 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" downshifts 2645162 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" S_feature 2645207..2645513 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2645207..2645476) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" gene complement(2645207..2645476) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" downshifts complement(2645223) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" downshifts complement(2645392) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" downshifts 2645470 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" CDS complement(2645533..2645892) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" gene complement(2645533..2645892) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" downshifts complement(2645546) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" CDS complement(2645924..2646124) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" gene complement(2645924..2646124) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" CDS complement(2646137..2646658) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" gene complement(2646137..2646658) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" misc_RNA complement(2646720..2646859) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" gene complement(2646720..2646859) /locus_tag="BSU_misc_RNA_47" promotor_-10 complement(2646856..2646875) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2646866) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" S_feature complement(2646868..2646932) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2646889..2646896) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2646914..2646933) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2646932) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" promotor_-35 complement(2646949..2646953) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2647051..2647058 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2647072..2647090 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2647072 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" CDS 2647104..2647769 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" gene 2647104..2647769 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" downshifts 2647747 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" CDS complement(2647801..2648496) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" gene complement(2647801..2648496) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" downshifts complement(2647823) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" downshifts complement(2647867) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" CDS complement(2648518..2648958) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" gene complement(2648518..2648958) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" promotor_-10 complement(2648980..2648999) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2648999) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" promotor_-35 complement(2649015..2649018) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2649092..2649817) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" gene complement(2649092..2649817) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" downshifts complement(2649121) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" CDS complement(2649795..2651576) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" gene complement(2649795..2651576) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" promotor_-35 2651660..2651663 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2651672..2651691) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2651677) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2651678..2651697 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2651685 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" CDS 2651743..2652525 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" gene 2651743..2652525 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" downshifts 2652509 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" downshifts complement(2652559) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" CDS complement(2652566..2654497) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" gene complement(2652566..2654497) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" misc_RNA complement(2654541..2654788) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene complement(2654541..2654788) /gene="tboT" /locus_tag="BSU_misc_RNA_48" promotor_-10 complement(2654544..2654553) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2654544) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" promotor_-35 complement(2654572) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2654599) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" promotor_-10 complement(2654799..2654818) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2654812) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" S_feature complement(2654814..2654894) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2654834..2654838) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2654895..2655740) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" gene complement(2654895..2655740) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" promotor_-10 complement(2655760..2655778) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2655766) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" promotor_-35 complement(2655794..2655799) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2655819..2656460) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" gene complement(2655819..2656460) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" CDS complement(2656494..2657429) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" gene complement(2656494..2657429) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" CDS complement(2657457..2658875) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" gene complement(2657457..2658875) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" promotor_-10 complement(2658904..2658923) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2658912) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" promotor_-35 complement(2658938..2658941) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2658990..2659448) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" gene complement(2658990..2659448) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" downshifts complement(2659009) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" S_feature complement(2659449..2659596) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2659587..2659606) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2659596) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" S_feature complement(2659598..2659676) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2659621..2659624) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2659721) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" CDS complement(2659722..2660102) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" gene complement(2659722..2660102) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" S_feature complement(2660103..2660257) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2660237..2660256) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2660244 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 2660245..2660264 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2660257) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" promotor_-35 complement(2660271..2660277) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2660335..2660346) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2660341..2661363) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" gene complement(2660341..2661363) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" upshifts complement(2660342) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" promotor_-35 complement(2660361..2660367) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2661407..2661426) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2661438) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" promotor_-35 complement(2661439..2661446) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2661569..2661949) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" gene complement(2661569..2661949) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" downshifts complement(2661593) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" S_feature complement(2661950..2662080) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2662005..2662009 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2662025..2662044 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2662026..2662132 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2662026 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" promotor_-10 complement(2662070..2662089) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2662080) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" promotor_-35 complement(2662104..2662111) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2662133..2663323 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" gene 2662133..2663323 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" promotor_-10 complement(2662955..2662973) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2662971) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2662989..2662994) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2663347..2664189 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" gene 2663347..2664189 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" promotor_-35 2663962..2663967 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2663983..2664001 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2663984 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2664182 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" downshifts complement(2664222) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" CDS complement(2664231..2664824) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" gene complement(2664231..2664824) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" CDS complement(2664840..2665472) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" gene complement(2664840..2665472) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" S_feature complement(2665473..2665637) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2665638..2666468) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" gene complement(2665638..2666468) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" CDS complement(2666491..2669133) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" gene complement(2666491..2669133) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" promotor_-10 complement(2669188..2669207) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2669197) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" promotor_-35 complement(2669221..2669228) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2669257..2669376) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2669300) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" CDS complement(2669377..2671116) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" gene complement(2669377..2671116) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" CDS complement(2671109..2671831) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" gene complement(2671109..2671831) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" promotor_-10 complement(2671899..2671918) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2671909) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" S_feature complement(2671911..2672011) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2671932..2671938) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2672043..2672981) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" gene complement(2672043..2672981) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" downshifts complement(2672056) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" CDS complement(2673025..2674296) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" gene complement(2673025..2674296) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" misc_feature complement(2674081..2674100) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2674093) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" S_feature complement(2674297..2674379) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2674379) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" S_feature complement(2674381..2674459) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2674381..2674400) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2674416..2674420) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2674460..2675578) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" gene complement(2674460..2675578) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" downshifts 2675073 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" misc_feature 2675420..2675423 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2675428 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2675557 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" S_feature complement(2675579..2675785) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2675753..2675765 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2675764 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2675771..2675790) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2675785) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" promotor_-35 complement(2675805..2675809) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2675905) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" CDS complement(2675912..2676376) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" gene complement(2675912..2676376) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" promotor_-10 complement(2676389..2676408) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2676403) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" S_feature complement(2676405..2677590) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2676405..2676410 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2676421..2676429) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2676425..2676443 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2676431 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" CDS 2676473..2677588 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" gene 2676473..2677588 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" downshifts 2677559 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" CDS complement(2677621..2678004) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" gene complement(2677621..2678004) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" downshifts complement(2677635) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" S_feature complement(2678005..2678096) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2678097..2679854) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" gene complement(2678097..2679854) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" CDS complement(2679897..2680856) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" gene complement(2679897..2680856) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" S_feature complement(2680857..2680958) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2680947..2680966) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2680958) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" promotor_-35 complement(2680982..2680986) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2681040..2682017) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" gene complement(2681040..2682017) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" downshifts complement(2681067) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" CDS complement(2682002..2682874) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" gene complement(2682002..2682874) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" promotor_-35 2682836..2682841 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2682857..2682875 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2682861..2684035 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2682861 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" S_feature complement(2682875..2682958) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2682947..2682966) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2682958) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" S_feature complement(2682960..2683112) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2682982..2682986) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2683114..2683208) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2683157) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" CDS complement(2683209..2684441) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" gene complement(2683209..2684441) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" S_feature complement(2684442..2684558) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2684546..2684565) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2684558) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" CDS complement(2684578..2687925) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" gene complement(2684578..2687925) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" promotor_-35 complement(2684579..2684586) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2685590..2685599 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2685611..2685626 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2685611 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2685799..2685818) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2685818) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" promotor_-35 complement(2685832..2685839) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2687956..2687975) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2687974) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" promotor_-35 complement(2687989..2687996) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2688014..2688019 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2688031 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" promotor_-10 2688035..2688053 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2688065..2688406 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" gene 2688065..2688406 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" CDS 2688403..2688906 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" gene 2688403..2688906 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" promotor_-35 2688939..2688942 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2688957..2688976 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2688957 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" CDS 2689008..2689199 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" gene 2689008..2689199 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" downshifts complement(2689009) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" downshifts 2689175 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" CDS complement(2689217..2690158) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" gene complement(2689217..2690158) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" S_feature 2689220..2689591 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2689252) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" promotor_-35 2689560..2689569 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2689583..2689602 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2689593..2689987 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2689593 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" promotor_-35 2689949..2689955 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2689971..2689990 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2689989..2690288 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2689989 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" promotor_-10 complement(2690177..2690196) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2690193) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" S_feature complement(2690195..2690609) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2690211..2690214) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2690289..2690591 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" gene 2690289..2690591 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" S_feature 2690592..2692387 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2690610..2691929) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" gene complement(2690610..2691929) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" promotor_-10 complement(2691955..2691974) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2691976) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" promotor_-35 complement(2691989..2691994) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2692105..2693007) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" gene complement(2692105..2693007) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" CDS complement(2693026..2694276) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" gene complement(2693026..2694276) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" CDS complement(2694294..2694986) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" gene complement(2694294..2694986) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" CDS complement(2695033..2696361) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" gene complement(2695033..2696361) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" CDS complement(2696358..2696639) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" gene complement(2696358..2696639) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" CDS complement(2696654..2697658) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" gene complement(2696654..2697658) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" CDS complement(2697655..2698434) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" gene complement(2697655..2698434) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" CDS complement(2698431..2699138) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" gene complement(2698431..2699138) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" CDS complement(2699168..2699887) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" gene complement(2699168..2699887) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" promotor_-35 2699713..2699720 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2699735..2699754 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2699735 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2699909..2700721) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" gene complement(2699909..2700721) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" CDS complement(2700735..2701544) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" gene complement(2700735..2701544) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" CDS complement(2701558..2702094) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" gene complement(2701558..2702094) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" promotor_-35 2702131..2702138 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2702149..2702168) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2702152..2702171 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2702155..2702246 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2702155 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" upshifts complement(2702165) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" promotor_-35 complement(2702182..2702189) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2702247..2703173 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" gene 2702247..2703173 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" S_feature complement(2702649..2703178) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2703223) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" CDS complement(2703224..2703907) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" gene complement(2703224..2703907) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" S_feature complement(2703908..2703969) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2703970..2704737) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" gene complement(2703970..2704737) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" promotor_-10 complement(2704782..2704801) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2704804) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" promotor_-35 complement(2704817..2704819) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2704864..2705100) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" gene complement(2704864..2705100) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" downshifts 2704949 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" downshifts complement(2704969) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" CDS complement(2705060..2706445) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" gene complement(2705060..2706445) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" CDS complement(2706442..2707653) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" gene complement(2706442..2707653) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" S_feature complement(2707654..2707731) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2707724..2707743) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2707730) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" promotor_-35 complement(2707758..2707765) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2707823..2708335) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" gene complement(2707823..2708335) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" downshifts complement(2707841) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2708361..2708380) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2708369) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" promotor_-35 complement(2708394..2708401) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2708420..2709607) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" gene complement(2708420..2709607) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" downshifts complement(2708435) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" S_feature complement(2709608..2709712) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2709697..2709716) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2709712) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" S_feature complement(2709714..2709843) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2709732..2709736) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2709780..2709983) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" gene complement(2709780..2709983) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" promotor_-10 complement(2709841..2709852) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2709843) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" promotor_-35 complement(2709867..2709873) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2709955..2710944) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" gene complement(2709955..2710944) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" downshifts complement(2709973) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" CDS complement(2711005..2711508) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" gene complement(2711005..2711508) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" downshifts complement(2711011) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" promotor_no_box 2711225..2711325 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2711285 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2711504 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2711531..2711550) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2711547) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" promotor_-35 complement(2711564..2711571) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2711618..2712073) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" gene complement(2711618..2712073) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" downshifts complement(2711646) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" CDS complement(2712087..2712767) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" gene complement(2712087..2712767) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" upshifts complement(2712179) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" promotor_-10 complement(2712186..2712197) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2712212..2712218) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2712505) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" promotor_-10 complement(2712780..2712798) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2712794) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" promotor_-35 complement(2712813..2712818) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2712842..2713336) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" gene complement(2712842..2713336) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" downshifts complement(2712857) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" CDS complement(2713349..2714356) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" gene complement(2713349..2714356) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" promotor_-10 complement(2714380..2714395) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2714397) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" S_feature complement(2714399..2714478) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2714407..2714416) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2714456..2714475 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2714466 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" promotor_-10 complement(2714471..2714490) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2714475..2714541 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2714478) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" promotor_-35 complement(2714506..2714510) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2714542..2715345 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" gene 2714542..2715345 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" downshifts 2715275 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" downshifts 2715333 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" CDS complement(2715377..2716966) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" gene complement(2715377..2716966) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" downshifts complement(2715386) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" CDS complement(2716986..2718575) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" gene complement(2716986..2718575) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" promotor_-10 complement(2718621..2718638) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2718626) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" promotor_-35 complement(2718654..2718660) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2718753) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" CDS complement(2718754..2718963) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" gene complement(2718754..2718963) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" promotor_-35 2718959..2718963 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2718963 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2718972..2718986 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2718984..2718995) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2718995) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" promotor_-35 complement(2719010..2719016) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2719057..2720262) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" gene complement(2719057..2720262) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" CDS complement(2720266..2721411) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" gene complement(2720266..2721411) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" S_feature complement(2721412..2722555) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2721498..2721505 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2721516..2721605 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2721516 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" promotor_-10 2721518..2721537 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2721606..2722943 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" gene 2721606..2722943 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" promotor_-10 complement(2722541..2722560) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2722555) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" promotor_-35 complement(2722575..2722582) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2722919 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" CDS complement(2723038..2724726) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" gene complement(2723038..2724726) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" downshifts complement(2723039) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" S_feature complement(2724727..2724832) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2724809..2724817 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2724820..2724839) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2724828..2724847 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2724832) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" upshifts 2724832 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" S_feature 2724833..2724922 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2724834..2725393) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2724855..2724857) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2724923..2725729 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" gene 2724923..2725729 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" promotor_-10 complement(2725397..2725416) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2725410) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" promotor_-35 complement(2725428..2725435) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2725679..2725725) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2725701) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" CDS complement(2725726..2726349) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" gene complement(2725726..2726349) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" S_feature 2725730..2726072 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2726050..2726057 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2726072..2726091 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2726074..2726217 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2726074 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" promotor_-35 2726189..2726193 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2726209..2726228 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2726219..2726349 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2726219 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" S_feature 2726351..2726475 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2726351 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" promotor_-10 complement(2726365..2726383) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2726367..2726386 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2726383) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" promotor_-35 complement(2726394..2726402) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2726476..2726967 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" gene 2726476..2726967 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" downshifts 2726946 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" CDS complement(2727005..2728744) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" gene complement(2727005..2728744) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" downshifts complement(2727023) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" promotor_-35 2728218..2728225 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2728239..2728257 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2728242 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" S_feature 2728244..2728839 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2728774..2728793) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2728782) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" S_feature complement(2728784..2729617) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2728820..2728827 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2728841..2729038 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2728841..2728860 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2728841 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" misc_RNA 2728898..2729030 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" gene 2728898..2729030 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" CDS 2729039..2729641 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" gene 2729039..2729641 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" downshifts 2729564 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" S_feature complement(2729619..2729838) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2729627 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" downshifts complement(2729662) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" downshifts 2729674 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" S_feature 2729719..2729892 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2729834..2729852) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2729846) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" downshifts 2729850 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" promotor_-35 complement(2729867..2729873) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2729912..2731180) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" gene complement(2729912..2731180) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" downshifts complement(2729938) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" misc_RNA complement(2731204..2731477) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" gene complement(2731204..2731477) /gene="tboY" /locus_tag="BSU_misc_RNA_83" S_feature complement(2731225..2731368) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2731268) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" promotor_-10 complement(2731475..2731494) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2731487) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" promotor_-35 complement(2731507..2731514) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2731522..2733240) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" gene complement(2731522..2733240) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" promotor_-35 2733254..2733261 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2733268..2733287) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2733276..2733295 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2733282 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(2733291) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" promotor_-35 complement(2733301..2733307) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2733324..2733331 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2733345..2733364 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2733348 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" CDS 2733401..2734033 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" gene 2733401..2734033 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" promotor_-35 2733606..2733614 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2733628..2733647 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2733634 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" CDS 2734060..2734704 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" gene 2734060..2734704 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" CDS 2734701..2735864 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" gene 2734701..2735864 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" downshifts 2735855 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" CDS complement(2735875..2736603) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" gene complement(2735875..2736603) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" downshifts complement(2735911) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" CDS complement(2736593..2737411) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" gene complement(2736593..2737411) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" CDS complement(2737474..2738478) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" gene complement(2737474..2738478) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" downshifts complement(2737491) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" misc_feature complement(2738513..2738532) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2738528) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" S_feature complement(2738530..2738638) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2738638..2738657) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2738638) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" S_feature complement(2738640..2738705) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2738671..2738677) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2738751) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" CDS complement(2738754..2739830) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" gene complement(2738754..2739830) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" promotor_-10 complement(2739871..2739890) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2739891) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" S_feature complement(2739893..2739993) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2739905..2739912) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2739927 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" promotor_-10 complement(2739981..2740000) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2739993) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" promotor_-35 complement(2740014..2740020) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2740066..2740392) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" gene complement(2740066..2740392) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" downshifts complement(2740075) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" CDS complement(2740416..2740871) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" gene complement(2740416..2740871) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" CDS complement(2740902..2741324) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" gene complement(2740902..2741324) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" promotor_-10 complement(2741345..2741363) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2741358) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" promotor_-35 complement(2741377..2741383) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2741397..2741415) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2741406) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" promotor_-35 complement(2741426..2741434) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2741486..2742784) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" gene complement(2741486..2742784) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" downshifts complement(2741495) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" promotor_-10 complement(2742809..2742828) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2742810) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" S_feature complement(2742812..2743008) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2742841..2742850) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2742991..2743010) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2743008) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" promotor_-35 complement(2743022..2743028) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2743034..2745892) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" gene complement(2743034..2745892) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" promotor_-10 complement(2745926..2745945) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2745936) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" promotor_-35 complement(2745961..2745965) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2746035) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" CDS complement(2746052..2746657) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" gene complement(2746052..2746657) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" CDS complement(2746673..2747482) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" gene complement(2746673..2747482) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" CDS complement(2747497..2747820) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" gene complement(2747497..2747820) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" S_feature complement(2747821..2747959) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2747859..2747975) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" gene complement(2747859..2747975) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" promotor_-10 complement(2747946..2747965) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2747959) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" promotor_-35 2747967..2747974 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2747981) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-35" promotor_-10 2747989..2748008 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2747994 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" CDS 2748055..2748501 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" gene 2748055..2748501 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" S_feature 2748502..2749230 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2748556..2749629) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" gene complement(2748556..2749629) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" downshifts complement(2748575) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2749651..2749670) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2749655) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" promotor_-35 complement(2749684..2749691) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2749726..2749729 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2749744..2749763 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2749749 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" CDS 2749788..2750105 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" gene 2749788..2750105 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" downshifts 2750105 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" CDS complement(2750158..2751858) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" gene complement(2750158..2751858) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" downshifts complement(2750177) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" promotor_-10 complement(2751890..2751908) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2751897) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" promotor_-35 complement(2751923..2751929) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2751940..2752710) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" gene complement(2751940..2752710) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" S_feature complement(2752711..2752799) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2752797..2752816) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2752799) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" promotor_-35 complement(2752832..2752836) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2752856..2753497) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" gene complement(2752856..2753497) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" downshifts complement(2752866) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" downshifts complement(2752931) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" promotor_-10 complement(2753523..2753542) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2753532) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" S_feature complement(2753534..2753982) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2753558..2753562) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2753641..2753647 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2753662..2753673 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2753669 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" CDS 2753704..2753982 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" gene 2753704..2753982 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" S_feature 2753983..2754153 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2753983..2754597) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" gene complement(2753983..2754597) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" downshifts 2754131 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" S_feature complement(2754598..2754933) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2754925..2754944) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2754933) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" promotor_-35 complement(2754959..2754966) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2754960..2757116) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" gene complement(2754960..2757116) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" CDS complement(2757142..2758071) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" gene complement(2757142..2758071) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" CDS complement(2758120..2759034) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" gene complement(2758120..2759034) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" promotor_-10 complement(2758797..2758815) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2758805) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" promotor_-35 complement(2758829..2758835) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2759060..2759611) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" gene complement(2759060..2759611) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" misc_feature 2759474..2759493 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2759477 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2759634..2759653) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2759646) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" promotor_-35 complement(2759669..2759672) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2759694..2759701 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2759712..2759731 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2759715..2759726) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2759719 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" upshifts complement(2759729) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" promotor_-35 complement(2759740..2759746) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2759760..2760695 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" gene 2759760..2760695 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" downshifts 2760671 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" CDS complement(2760729..2762120) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" gene complement(2760729..2762120) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" downshifts complement(2760741) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" S_feature complement(2762121..2762561) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2762147..2762152 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2762166..2762185 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2762179 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" CDS 2762217..2763515 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" gene 2762217..2763515 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" promotor_-10 complement(2762538..2762557) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2762561) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" promotor_-35 complement(2762572..2762578) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2763502 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" CDS complement(2763555..2764712) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" gene complement(2763555..2764712) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" downshifts complement(2763580) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" promotor_-35 2763828..2763833 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2763848..2763866 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2763856 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2764709..2765419) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" gene complement(2764709..2765419) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" promotor_-10 complement(2765433..2765448) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2765450) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" promotor_-35 complement(2765460..2765469) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2765476..2765477 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2765489..2765594 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2765489 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" promotor_-10 2765497..2765507 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2765560..2765566 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2765581..2765600 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2765596..2765709 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2765596 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" CDS 2765710..2765931 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" gene 2765710..2765931 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" downshifts 2765914 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" downshifts 2765983 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" CDS complement(2766052..2766771) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" gene complement(2766052..2766771) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" downshifts complement(2766066) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" downshifts complement(2766837) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" CDS complement(2766840..2768474) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" gene complement(2766840..2768474) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" misc_feature complement(2768506..2768525) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2768522) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" promotor_-35 2768592..2768596 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2768612..2768631 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2768630 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" CDS 2768676..2769938 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" gene 2768676..2769938 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" S_feature 2769939..2770037 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2770011..2770017 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2770033..2770051 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2770039..2770126 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2770039 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" CDS 2770127..2771665 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" gene 2770127..2771665 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" downshifts 2771645 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" CDS complement(2771702..2771884) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" gene complement(2771702..2771884) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" downshifts complement(2771721) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2771899..2771917) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2771919) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" promotor_-35 complement(2771933..2771938) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2771952..2772620) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" gene complement(2771952..2772620) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" CDS complement(2772642..2773928) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" gene complement(2772642..2773928) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" CDS complement(2773940..2774443) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" gene complement(2773940..2774443) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" CDS complement(2774440..2775561) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" gene complement(2774440..2775561) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" CDS complement(2775569..2776534) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" gene complement(2775569..2776534) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" upshifts complement(2776560) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" promotor_-10 complement(2776561..2776580) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2776595..2776602) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2776690..2776697 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2776710 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" promotor_-10 2776713..2776732 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2776750..2779068 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" gene 2776750..2779068 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" downshifts 2779058 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" CDS complement(2779109..2780605) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" gene complement(2779109..2780605) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" downshifts complement(2779111) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" CDS complement(2780630..2781490) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" gene complement(2780630..2781490) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" promotor_-10 complement(2781566..2781585) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2781575) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" promotor_-35 complement(2781601..2781608) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2781697..2782458) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" gene complement(2781697..2782458) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" downshifts complement(2781726) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" S_feature complement(2782459..2782534) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2782535..2783722) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" gene complement(2782535..2783722) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" CDS complement(2783791..2784798) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" gene complement(2783791..2784798) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" CDS complement(2784801..2785496) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" gene complement(2784801..2785496) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" CDS complement(2785493..2786662) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" gene complement(2785493..2786662) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" promotor_-35 2785529..2785536 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2785551..2785570 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2785569 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2786652..2787998) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" gene complement(2786652..2787998) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" promotor_-35 2787068..2787072 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2787087 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2787088..2787106 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2787988..2788764) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" gene complement(2787988..2788764) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" S_feature complement(2788765..2788857) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2788843..2788862) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2788857) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" promotor_-35 complement(2788877..2788884) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2788974..2789873) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" gene complement(2788974..2789873) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" promotor_-10 complement(2789896..2789914) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2789913) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2789925..2789933) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2790003..2790010 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2790026..2790045 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2790032 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" CDS 2790091..2791125 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" gene 2790091..2791125 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" promotor_-35 2791074..2791081 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2791096..2791104 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2791113 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" CDS 2791159..2792439 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" gene 2791159..2792439 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" CDS 2792432..2793343 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" gene 2792432..2793343 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" CDS 2793340..2794170 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" gene 2793340..2794170 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" promotor_-35 2794143..2794147 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2794163..2794182 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2794171 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2794190..2795488 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" gene 2794190..2795488 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" downshifts 2795469 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" CDS complement(2795510..2795821) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" gene complement(2795510..2795821) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" downshifts complement(2795521) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" promotor_-10 complement(2795845..2795864) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2795853) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" promotor_-35 complement(2795879..2795886) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2795887 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" CDS complement(2795938..2798352) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" gene complement(2795938..2798352) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" downshifts complement(2795942) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" S_feature complement(2798353..2798448) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2798462..2798676) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" gene complement(2798462..2798676) /gene="tboL" /locus_tag="BSU_misc_RNA_49" downshifts complement(2798493) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2798688..2798707) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2798709) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" promotor_-35 2798713..2798718 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2798722..2798727) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2798734..2798752 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2798747..2799187 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2798747 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" CDS complement(2798779..2799114) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" gene complement(2798779..2799114) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" S_feature complement(2799109..2799373) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2799358..2799377) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2799373) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" promotor_-35 complement(2799392..2799399) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2799412..2799419 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2799433..2799452 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2799449 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" S_feature 2799451..2799518 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2799519..2800304 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" gene 2799519..2800304 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" S_feature 2800305..2800361 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2800541..2801734) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" gene complement(2800541..2801734) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" downshifts complement(2800561) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" S_feature complement(2801735..2801833) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2801814..2801833) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2801833) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" promotor_-35 complement(2801847..2801854) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2801871..2801874 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2801889..2801908 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2801893 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" CDS 2801923..2802669 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" gene 2801923..2802669 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" downshifts 2802564 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" downshifts 2802663 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" CDS complement(2802706..2804646) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" gene complement(2802706..2804646) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" downshifts complement(2802717) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" CDS complement(2804636..2805397) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" gene complement(2804636..2805397) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" misc_feature complement(2805421..2805439) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2805440) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" CDS complement(2805499..2806503) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" gene complement(2805499..2806503) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" downshifts complement(2805538) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" CDS complement(2806496..2807191) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" gene complement(2806496..2807191) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" promotor_-10 complement(2807215..2807233) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2807227) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" promotor_-35 complement(2807249..2807252) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2807288..2808598) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" gene complement(2807288..2808598) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" downshifts complement(2807310) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" CDS complement(2808588..2809283) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" gene complement(2808588..2809283) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" CDS complement(2809298..2810275) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" gene complement(2809298..2810275) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" CDS complement(2810305..2811291) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" gene complement(2810305..2811291) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" promotor_-35 2811161..2811170 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2811177 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2811183..2811198 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2811285..2812163) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" gene complement(2811285..2812163) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" CDS complement(2812156..2812548) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" gene complement(2812156..2812548) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" S_feature complement(2812549..2812793) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2812582..2812719) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" gene complement(2812582..2812719) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" downshifts 2812717 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" promotor_-10 complement(2812788..2812807) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2812793) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" promotor_-35 complement(2812821..2812828) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2812874..2813146) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" gene complement(2812874..2813146) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" downshifts complement(2812881) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2813186..2813197) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2813190..2813198 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2813190) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" upshifts 2813201 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" promotor_-10 2813212..2813230 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2813212..2813218) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2813241..2813246 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2813260..2813279 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2813267 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" CDS 2813308..2814276 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" gene 2813308..2814276 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" CDS 2814273..2814857 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" gene 2814273..2814857 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" downshifts 2814821 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" CDS complement(2814847..2815950) /gene="tbcS" /locus_tag="BSU_30500" /old_locus_tag="BSU30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /translation="MTVPEHPFGLMAKVYRDIFPLVHQELDIWKQKSESIHNSELKAQ ATASIRDKTFHCEGGGILALLSGSQKQKCVEFIIAYQTISDYLDNLCDRSTSLDPQDF RMLHASMQDALTVGAELQNYYQFREEQDDSGYLHELVKTCQRVLGSIEHYDMIKPYLL ELCGYYCDLQVHKHVIEHERVPRLEKWFTQYESELPEMEWYEFSACAGSTLGIFCLVA YSFQPDFTESTAKKIRDSYFPYIQGLHILLDYLIDQEEDLLEGDLNFCSYYQSHEEMM DRLEHFIHKADEHLQGIPHENFHRLINRGLLGVYLSDDKVAGQKEMGRLAKKLIKASG KTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC*" gene complement(2814847..2815950) /gene="tbcS" /locus_tag="BSU_30500" /old_locus_tag="BSU30500" downshifts complement(2814888) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" CDS complement(2815971..2816750) /gene="ytpA" /locus_tag="BSU_30510" /old_locus_tag="BSU30510" /EC_number="3.1.-.-" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11796336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11796336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospholipase component of bacilysocin synthesisor export" /protein_id="NP_390929.1" /db_xref="EnsemblGenomes-Gn:BSU30510" /db_xref="EnsemblGenomes-Tr:CAB15029" /db_xref="GOA:O34705" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13900" /db_xref="UniProtKB/Swiss-Prot:O34705" /translation="MWTWKADRPVAVIVIIHGASEYHGRYKWLIEMWRSSGYHVVMGD LPGQGTTTRARGHIRSFQEYIDEVDAWIDKARTFDLPVFLLGHSMGGLVAIEWVKQQR NPRITGIILSSPCLGLQIKVNKALDLASKGLNVIAPSLKVDSGLSIDMATRNEDVIEA DQNDSLYVRKVSVRWYRELLKTIESAMVPTEAFLKVPLLVMQAGDDKLVDKTMVIKWF NGVASHNKAYREWEGLYHEIFNEPEREDVFKAARAFTDQYI*" gene complement(2815971..2816750) /gene="ytpA" /locus_tag="BSU_30510" /old_locus_tag="BSU30510" promotor_-35 2816393..2816400 /Source="Nicolas_upshift_promotors" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2816415..2816434 /Source="Nicolas_upshift_promotors" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2816432 /Source="Nicolas_upshifts" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" S_feature complement(2816751..2817330) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" CDS 2816799..2817314 /gene="ytoA" /locus_tag="BSU_30520" /old_locus_tag="BSU30520" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22868757; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of the carbonic anhydrase family" /protein_id="NP_390930.1" /db_xref="EnsemblGenomes-Gn:BSU30520" /db_xref="EnsemblGenomes-Tr:CAB15030" /db_xref="GOA:O34696" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG13896" /db_xref="UniProtKB/Swiss-Prot:O34696" /translation="MIYPYKEHKPDIHPTAFIADNATITGDVVIGEQSSIWFSVVIRG DVAPTRIGNRVNIQDLSCLHQSPNKTLLIEDDATIGHQVTLHSAVIRKNALIGMGSII LDGAEIGEGAFIGAGSLVPPGKIIPPGHLAFGRPAKVIRPLTEEDRKDMQRIRSEYVE KGQYYKFLQQT*" gene 2816799..2817314 /gene="ytoA" /locus_tag="BSU_30520" /old_locus_tag="BSU30520" promotor_-10 complement(2817321..2817340) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2817330) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" S_feature complement(2817332..2817466) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2817352..2817359) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2817441..2817460) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2817466) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" CDS complement(2817559..2818950) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" gene complement(2817559..2818950) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" downshifts complement(2817567) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" S_feature complement(2818951..2819085) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2819086..2820984) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" gene complement(2819086..2820984) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" promotor_-35 2820142..2820148 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2820163..2820174 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2820175 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2820985..2821108) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2821134..2822336) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" gene complement(2821134..2822336) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" downshifts complement(2821153) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" promotor_-10 complement(2822379..2822390) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2822385) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" S_feature complement(2822387..2822503) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2822404..2822410) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2822504..2822642) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene complement(2822504..2822642) /gene="mswG" /locus_tag="BSU_misc_RNA_50" downshifts 2822602 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" promotor_-10 complement(2822651..2822670) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2822666) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" promotor_-35 complement(2822687..2822691) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2822763..2822770 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2822782 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" promotor_-10 2822784..2822803 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2822839..2824422 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" gene 2822839..2824422 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" downshifts 2824411 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" CDS complement(2824461..2824703) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" gene complement(2824461..2824703) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" downshifts complement(2824475) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" CDS complement(2824755..2825528) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" gene complement(2824755..2825528) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" S_feature complement(2825529..2825619) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2825595..2825604 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2825608..2825627) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2825616 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" promotor_-10 2825617..2825636 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2825621) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" promotor_-35 complement(2825642..2825649) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2825679..2826683 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" gene 2825679..2826683 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" CDS 2826696..2827478 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" gene 2826696..2827478 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" S_feature complement(2826700..2828248) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2827453..2828265 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" gene 2827453..2828265 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" downshifts 2828250 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" CDS complement(2828292..2828768) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" gene complement(2828292..2828768) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" downshifts complement(2828293) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" misc_feature complement(2828798..2828817) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2828811) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" S_feature complement(2828813..2828947) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2828947) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" promotor_-10 complement(2828949..2828960) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2828975..2828981) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2828977..2829381) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" gene complement(2828977..2829381) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" promotor_-10 complement(2829409..2829428) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2829426) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" S_feature complement(2829428..2829514) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2829441..2829450) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2829547..2829984) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" gene complement(2829547..2829984) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" downshifts complement(2829559) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2830001..2830019) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2830019) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" S_feature complement(2830021..2830246) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2830034..2830040) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2830076..2830095 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2830077..2830253 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" gene 2830077..2830253 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" upshifts 2830078 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" CDS complement(2830247..2830684) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" gene complement(2830247..2830684) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" downshifts 2830273 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2830703..2830722) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2830724) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" promotor_-35 complement(2830733..2830741) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2830804..2831277) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" gene complement(2830804..2831277) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" downshifts complement(2830813) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" downshifts complement(2830900) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" S_feature complement(2831278..2831629) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2831349..2831356 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2831369..2831388 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2831374 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2831406..2831633 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" gene 2831406..2831633 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" CDS complement(2831630..2832193) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" gene complement(2831630..2832193) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" misc_feature complement(2832218..2832237) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2832233) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" CDS complement(2832287..2832535) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" gene complement(2832287..2832535) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" downshifts complement(2832308) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" promotor_-10 complement(2832563..2832582) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2832596..2832603) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2832600) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" promotor_-35 2832662..2832668 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2832682..2832693 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2832694 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" CDS 2832740..2834071 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" gene 2832740..2834071 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" CDS 2834115..2835155 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" gene 2834115..2835155 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" promotor_-35 2835149..2835155 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2835170..2835181 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2835180 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" CDS 2835209..2835367 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" gene 2835209..2835367 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" downshifts 2835356 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" CDS complement(2835386..2836273) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" gene complement(2835386..2836273) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" downshifts complement(2835409) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" CDS complement(2836263..2837570) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" gene complement(2836263..2837570) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" CDS complement(2837576..2838328) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" gene complement(2837576..2838328) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" CDS complement(2838347..2839267) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" gene complement(2838347..2839267) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" promotor_-10 complement(2839303..2839314) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2839304) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2839306..2839397) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2839328..2839334) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2839382 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2839383..2839402) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2839385..2839397 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2839397) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" S_feature complement(2839399..2839480) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2839417..2839424) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2839480) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" promotor_-10 complement(2839489..2839508) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2839522..2839529) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2839547..2840662) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" gene complement(2839547..2840662) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" downshifts complement(2839590) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" CDS complement(2840659..2842119) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" gene complement(2840659..2842119) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" promotor_-10 complement(2841562..2841580) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2841566) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" promotor_-35 complement(2841595..2841601) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2842208) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" CDS complement(2842210..2843025) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" gene complement(2842210..2843025) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" CDS complement(2843060..2843884) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" gene complement(2843060..2843884) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" promotor_-10 complement(2843142..2843161) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2843142) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" promotor_-35 complement(2843177..2843180) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2843308) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" promotor_-10 complement(2843318..2843329) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2843344..2843350) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2843872..2845614) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" gene complement(2843872..2845614) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" CDS complement(2845611..2847026) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" gene complement(2845611..2847026) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" S_feature complement(2847027..2847139) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2847119..2847138) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2847139) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" S_feature complement(2847141..2847291) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2847154..2847157) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2847252..2847258 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2847272..2847291) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2847272..2847283 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2847280 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" upshifts complement(2847291) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" promotor_-35 complement(2847305..2847314) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2847316..2848035 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" gene 2847316..2848035 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" S_feature complement(2847386..2848043) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2848024 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" CDS complement(2848044..2848862) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" gene complement(2848044..2848862) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" promotor_-10 complement(2848883..2848902) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2848897) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" promotor_-35 complement(2848917..2848925) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2848963..2848971 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2848984..2849003 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2848985 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" CDS 2849034..2850320 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" gene 2849034..2850320 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" CDS 2850317..2851267 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" gene 2850317..2851267 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" CDS 2851270..2852493 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" gene 2851270..2852493 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" downshifts complement(2852417) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" S_feature 2852494..2853061 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2852567..2852998) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" gene complement(2852567..2852998) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" downshifts complement(2852593) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" CDS complement(2853000..2854055) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" gene complement(2853000..2854055) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" CDS complement(2854070..2855203) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" gene complement(2854070..2855203) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" promotor_-10 complement(2855236..2855255) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2855255) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" promotor_-35 complement(2855268..2855277) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2855341..2855350 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2855364..2855383 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2855366 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" CDS 2855393..2856466 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" gene 2855393..2856466 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" promotor_-35 2855690..2855696 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2855707 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" promotor_-10 2855710..2855721 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2856455 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" promotor_-35 2856493..2856499 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2856514 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" promotor_-10 2856515..2856533 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2856546..2857013 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" gene 2856546..2857013 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" downshifts 2856985 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" CDS complement(2857044..2859440) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" gene complement(2857044..2859440) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" downshifts complement(2857059) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" CDS complement(2859427..2860881) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" gene complement(2859427..2860881) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" CDS complement(2860878..2861909) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" gene complement(2860878..2861909) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" CDS complement(2861933..2863075) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" gene complement(2861933..2863075) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" CDS complement(2863072..2864955) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" gene complement(2863072..2864955) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" S_feature 2863781..2865200 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2864987..2865002) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2865000) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" promotor_-35 complement(2865017..2865022) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2865067) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" tRNA complement(2865188..2865259) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2865188..2865259) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" tRNA complement(2865285..2865375) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2865285..2865375) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" tRNA complement(2865379..2865453) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2865379..2865453) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" tRNA complement(2865464..2865540) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2865464..2865540) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" tRNA complement(2865556..2865629) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2865556..2865629) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" tRNA complement(2865640..2865715) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2865640..2865715) /gene="trnB-His" /locus_tag="BSU_tRNA_67" tRNA complement(2865733..2865808) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2865733..2865808) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" tRNA complement(2865821..2865897) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2865821..2865897) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" tRNA complement(2865909..2865985) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2865909..2865985) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" tRNA complement(2866003..2866095) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2866003..2866095) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" tRNA complement(2866102..2866178) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2866102..2866178) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" tRNA complement(2866181..2866257) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2866181..2866257) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" tRNA complement(2866277..2866349) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2866277..2866349) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" tRNA complement(2866355..2866431) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2866355..2866431) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" tRNA complement(2866447..2866523) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2866447..2866523) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" tRNA complement(2866533..2866618) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2866533..2866618) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" tRNA complement(2866633..2866707) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2866633..2866707) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" tRNA complement(2866713..2866799) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2866713..2866799) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" tRNA complement(2866810..2866885) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2866810..2866885) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" tRNA complement(2866923..2866998) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2866923..2866998) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" tRNA complement(2867031..2867106) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2867031..2867106) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" rRNA complement(2867127..2867244) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2867127..2867244) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" rRNA complement(2867300..2870227) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2867300..2870227) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" rRNA complement(2870395..2871949) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2870395..2871949) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" S_feature complement(2871950..2872241) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2872077..2872085 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2872083 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2872193 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(2872214..2872233) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2872241) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" S_feature complement(2872243..2873209) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2872247..2872254) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2872366..2872369 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2872381 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" promotor_-10 2872384..2872403 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2872414..2872515 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene 2872414..2872515 /gene="tswC" /locus_tag="BSU_misc_RNA_51" downshifts 2872514 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" CDS 2872615..2873193 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" gene 2872615..2873193 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" downshifts 2873183 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" CDS complement(2873235..2873756) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" gene complement(2873235..2873756) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" downshifts complement(2873253) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" downshifts complement(2873325) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" CDS complement(2873774..2875303) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" gene complement(2873774..2875303) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" CDS complement(2875324..2875848) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" gene complement(2875324..2875848) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" promotor_-10 complement(2875892..2875907) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2875898) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" S_feature complement(2875900..2875987) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2875919..2875928) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2875972..2875990) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2875982 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" misc_feature 2875986..2876005 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2875987) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" promotor_-35 complement(2876005..2876010) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2876016..2876504 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" gene 2876016..2876504 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" downshifts 2876481 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" CDS complement(2876510..2877088) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" gene complement(2876510..2877088) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" S_feature 2876526..2876917 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2876537) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2877122..2877141) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2877131) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" promotor_-35 complement(2877155..2877162) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2877176..2878384) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" gene complement(2877176..2878384) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" downshifts complement(2877197) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" promotor_-10 complement(2878153..2878172) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2878165) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2878187..2878194) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2878401..2879873) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" gene complement(2878401..2879873) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" promotor_-10 complement(2879924..2879943) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2879925) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" promotor_-35 complement(2879958..2879965) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2879985..2879991 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2880005..2880024 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2880020 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" CDS 2880072..2880614 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" gene 2880072..2880614 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" downshifts 2880597 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" promotor_-35 2880691..2880698 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2880711..2880811 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2880711 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" promotor_-10 2880713..2880732 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2880812..2881357 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" gene 2880812..2881357 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" downshifts 2881344 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" promotor_-35 2881449..2881456 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2881470..2881489 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2881477 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" misc_RNA 2881482..2881650 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" gene 2881482..2881650 /gene="swdA" /locus_tag="BSU_misc_RNA_52" downshifts 2881631 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" CDS 2881723..2882391 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" gene 2881723..2882391 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" CDS 2882398..2883735 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" gene 2882398..2883735 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" downshifts 2883721 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" CDS complement(2883771..2884034) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" gene complement(2883771..2884034) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" downshifts complement(2883789) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" promotor_-10 complement(2884074..2884093) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2884076) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" promotor_-35 complement(2884106..2884113) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2884143..2884991) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" gene complement(2884143..2884991) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" promotor_-10 complement(2885036..2885055) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2885046) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" promotor_-35 complement(2885070..2885077) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2885152..2886687) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" gene complement(2885152..2886687) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" downshifts complement(2885161) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" promotor_no_box 2886345..2886445 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2886405 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2886471 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" S_feature complement(2886688..2886855) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2886844..2886863) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2886855) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" S_feature complement(2886857..2887734) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2886878..2886885) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2887097..2887106 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2887120..2887139 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2887120 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" CDS 2887172..2887657 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" gene 2887172..2887657 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" S_feature 2887658..2887944 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2887764..2887836) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" gene complement(2887764..2887836) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" downshifts complement(2887779) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" downshifts complement(2887823) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" promotor_-10 complement(2887847..2887866) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2887867) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" promotor_-35 complement(2887881..2887884) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2887901 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" CDS complement(2887944..2888774) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" gene complement(2887944..2888774) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" downshifts complement(2887955) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" S_feature complement(2888775..2888866) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2888867..2890033) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" gene complement(2888867..2890033) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" promotor_-35 2890029..2890033 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2890041..2890055 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2890057..2890076) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2890057 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(2890076) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" promotor_-35 complement(2890090..2890097) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2890155..2890162 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2890168 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" promotor_-10 2890173..2890192 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2890215..2891201 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA*" gene 2890215..2891201 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" downshifts 2891172 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" CDS complement(2891242..2892516) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /EC_number="5.3.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose isomerase" /protein_id="NP_390996.1" /db_xref="EnsemblGenomes-Gn:BSU31180" /db_xref="EnsemblGenomes-Tr:CAB15096" /db_xref="GOA:O05264" /db_xref="InterPro:IPR009308" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG12387" /db_xref="UniProtKB/Swiss-Prot:O05264" /translation="MTIKANYDSAKQAYEKWGIDVEEALRQLEQVPISIHCWQGDDIE GFEVNKGELSGGIDVTGNYPGKAQTPEELRRDLEKALSLIPGKHRVNLHAIYAETNRE AVERDELKPQHFENWVKWAKNLGLGLDFNPTLFSHEKAADGLTLSHPDPDIREFWIRH CIACRRIGEYFGKELGTPCLTNIWIPDGYKDIPSDRLTPRKRLKESLDRIFSEEISEQ HNLDSIESKLFGLGSESYVVGSHEFYLAYALTNHKLCLLDTGHFHPTETVSNKISSML LYTDKLALHVSRPVRWDSDHVVVLDDELREIALEIVRNHALEKVAIGLDFFDASINRV AAWTIGTRNMIKALLYALLLPNGYLKQLQEEGRYTERLALMEEFKTYPFGAIWDSYCE QMGVPVKEAWLYDIKEYEQQVLLKRKASSPIV*" gene complement(2891242..2892516) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" downshifts complement(2891255) /Source="Nicolas_upshifts" /id="D1615" /incds=0 /nref=3 /ntot=29 /MaxReadThrough="0.802" /MaxDrop="4.45322" /score="14.0829844" /energy="-12.6" /TU="NA" /idTUdmin="U2421" /TUdmin=242 /isTUend="FALSE" CDS complement(2892542..2892856) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /EC_number="5.1.3.32" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15576793, 15876375, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576793, 15876375, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose mutarotase" /protein_id="NP_390997.1" /db_xref="EnsemblGenomes-Gn:BSU31190" /db_xref="EnsemblGenomes-Tr:CAB15097" /db_xref="GOA:O05263" /db_xref="InterPro:IPR008000" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR013448" /db_xref="SubtiList:BG12386" /db_xref="UniProtKB/Swiss-Prot:O05263" /translation="MKRKASIMFVHQDKYEEYKQRHDDIWPEMAEALKAHGAHHYSIF LDEETGRLFAYLEIEDEEKWRKMADTEVCQRWWKSMAPLMKTNSDFSPVAIDLKEVFY LD*" gene complement(2892542..2892856) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" CDS complement(2892874..2894331) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /EC_number="2.7.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16674975, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16674975, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnulokinase" /protein_id="NP_390998.1" /db_xref="EnsemblGenomes-Gn:BSU31200" /db_xref="EnsemblGenomes-Tr:CAB15098" /db_xref="GOA:O05262" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR013449" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG12385" /db_xref="UniProtKB/Swiss-Prot:O05262" /translation="MIYTAIDVGASSGRIMVGELNEGKLDIQEIHRFANGFSQRDGHC LWDIDHLLKQILQGLQKVKTLGYEHCTVGIDTWAVDYVLLDEKGDRLREAISYRDRRT DHTIDKLEHTLSKAAIYQKTGIQFQPFNTIYQLFEEDRELLKKTDKIMMIPDYLGYCL TGKAVTEITNVSTTQLLNVSTGNLDPELLEAVSVLEQQFAPLTEPGCELGKLRNEWFP DYDLPACKVMTVATHDTASAVIAAPGVNDGWAYISSGTWSLIGVENKTPIITDLALEN NYTNERGANNTIRFLKNIIGMWVIQEVKQQLQADYSFQQLAEEAKKTEPFQQFINLND KRFLNPENMIKEIQHYCRQTRQKIPRTAGELACCIYSNLAIIYAIAIKELETITEKPI EQFHIIGGGARNDFLNQLTADMSGKAVYAGPIEATATGNLLMQMIAAKEVKDIKEARQ VVRNSFPIKVFTPKDIDRSTIIQSFQQTVLKALSK*" gene complement(2892874..2894331) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" CDS complement(2894336..2895112) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11496004, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11496004, 26712933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the rhamnose operon(RhaR / l-rhamnulose-1-phosphate)" /protein_id="NP_390999.1" /db_xref="EnsemblGenomes-Gn:BSU31210" /db_xref="EnsemblGenomes-Tr:CAB15099" /db_xref="GOA:O05261" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12384" /db_xref="UniProtKB/Swiss-Prot:O05261" /translation="MLVAERQQKIVEIVNMRSSIRVSELSDIFSVTEETIRRDLEKLE KEHKLSRSHGGAVSIQQKESEIHFSEREITNVIEKKAIAHEAAKYVKSGDRIILDAST TAWYMAKILPDIELTVITNSMKAAIELSNKENISVISTGGILLEKSLSFAGPLAERSL ETYHVNKTFLSCKGFDVHNGMSDSNEWQALLKKRMIERSDQTILMADSSKWGNREFSH IASLQDVSRLITDSGLDPASVKALEDKKVKVTAVPLSKRG*" gene complement(2894336..2895112) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" misc_feature complement(2895146..2895165) /Source="Nicolas_upshift_promotors" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2895162) /Source="Nicolas_upshifts" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" CDS complement(2895169..2897238) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /EC_number="1.1.1.-" /EC_number="4.1.2.19" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24391637, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24391637, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase" /protein_id="NP_391000.1" /db_xref="EnsemblGenomes-Gn:BSU31220" /db_xref="EnsemblGenomes-Tr:CAB15100" /db_xref="GOA:P40747" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR013454" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG10947" /db_xref="UniProtKB/Swiss-Prot:P40747" /translation="MVKHIWDSERAAQLPKGVEELVYRSNLIGSDRTVCNWGGGNTSM KTTEKDFRGREIEVMWVKGSGSDLATMKAHNFSGLKLDDIRPLIKRDQMPDEEMVDYL SHCMIDSKHPRPSIETLLHAFLPYKHVDHTHPDAIISICCADNGKQIAEDIYGNRFVW VPYVRPGFTLSKMIAEGVANNPHAELVLMEKHGLVTWGETSETCYQKTISIIQEAEQY INDRINQHEVFGGKRYQPLPEDKRKQILAGIMPVIRGAVSEEKKMILSYDDHDDVLEF VNSVQAPALSQIGAACPDHLVHTKRVPLYIDWNPETQDVHKLADLIKSGVETFTSEYQ AYFTRNQQDGDQIFESAPRVILIPGIGMVNTGKSYAMSKVSGALYRRAIAVMKGATAL GQFVSLHENESYHVEYWPLELYKLTLAPPEAEFSRKVALITGGAGGIGSAACRRFAAE GGHVIVADLNIEGAQKIAGEINDAYGKGRAMAVKMDVTKEEDVQSAFERAALAYGGID IVVNNAGLATSSPFDETSLKEWNLNMNVLGTGYFLVAREAFKQMKHQNRGGSMVFVGS KNSVYAGKNASAYSSVKALETHLARCIAAEGGEFGIRVNSVLPDAVLQGSAIWGSSWR EERAAAYGIEPDQLEEHYRKRTALLVNIYPEDIAEAIAFFASSKAEKTTGCMITVDGG VPAAFTR*" gene complement(2895169..2897238) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" promotor_-10 complement(2897271..2897290) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2897283) /Source="Nicolas_upshifts" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" promotor_-35 complement(2897304..2897310) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2897376..2899364) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391001.1" /db_xref="EnsemblGenomes-Gn:BSU31230" /db_xref="EnsemblGenomes-Tr:CAB15101" /db_xref="GOA:P39217" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10862" /db_xref="UniProtKB/Swiss-Prot:P39217" /translation="MGKFIQWIKQPSISKPLIAAFLAVLILPVGVLAYFSYQSAWNAL DRELISSAKGNVEELNSTLQNKLEDKVKAIDYYSETVDKDILLGKNKTLLKEKFKQYT TLNDDVGAIYAASEDKKLYKYPDSGVPKGFDPTGRDWYKQAVAEKGQAVFSEPYTDEA TGDIVVTISKQLKDGSGVIALDLNLDEVLTASKRIKIGKEGFAFITTGNKKYIAHPTI KPGTTGSGDWTNQVYSKKEGSFEYTFEGKEKKMAFTTNKLTGWKIAGTYFVSELQDAS SPVLNTAVIILCVSIVIGGILILYIIRAITKPLRKLVSTSAKISSGDLTEVIDIHSKN EFGQLGESFNEMSASLRSVIGVIQTSVENVASSSEELTASAAQTSKATEHITLAIEQF SDGNEAQSEKLETSSNHLSQMNEGISKVAQASSTITKSSIQSSEAAGSGEKLVEHTVG QMKTIDQSVQKAEAVVKGLETKSQDITSILNVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIQEIVREISTSLSMFQSVNHEVKEGLQITDQ TAESFKQIYEMTTQISGELQNLNATVEQLSAGSQEVSSAVEDISAVAKESSAGIQDIA ASAEEQLASMEEISSSAETLANMAEELQDITKKFKIES*" gene complement(2897376..2899364) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" downshifts complement(2897395) /Source="Nicolas_upshifts" /id="D1616" /incds=0 /nref=108 /ntot=174 /MaxReadThrough="3.32915" /MaxDrop="6.75141" /score="18.7221191" /energy="-8.3" /TU="NA" /idTUdmin="U2423" /TUdmin="-2" /isTUend="TRUE" promotor_-35 2899368..2899375 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2899385..2899403) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2899391..2899410 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2899398) /Source="Nicolas_upshifts" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" upshifts 2899407 /Source="Nicolas_upshifts" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2899417..2899424) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2899473 /Source="Nicolas_upshifts" /id="D1617" /incds=0 /nref=4 /ntot=11 /MaxReadThrough="1.04089" /MaxDrop="4.2056" /score="13.4355481" /energy="-10.7" /TU="NA" /idTUdmin="U2424" /TUdmin=22 /isTUend="TRUE" CDS complement(2899478..2901463) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 9721285, 12011078" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 9721285, 12011078; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391002.2" /db_xref="EnsemblGenomes-Gn:BSU31240" /db_xref="EnsemblGenomes-Tr:CAB15102" /db_xref="GOA:P39214" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10861" /db_xref="UniProtKB/Swiss-Prot:P39214" /translation="MKKILQLIKQRSITRKLLVSFLSILIIPVVILAIFAYQSASSSL DRQMMGSALENVQQLNEIINTSIGEKENSADYFSEWLTKEKYNAKSNASIAEKFSQYI SINKDVESIYTSDTKGHFTRYPDLPMPSGYNPVERDWYKKAVANKGKVVITDPYKTAS TNTMVVTIAQQTKDGSGVIAINMTIENLLKTTKKVNIGTQGYAFIMTKDKKVVAHPNE QSGTELKGDWLDKMLSADKGDFQYTMDGDKKKMAFDTNKLTGWKIGGTMYLDEIHEAA QPVLHLALIVLAAAIIIGIIVMTLIIRSITTPLKQLVGSSKRISEGDLTETIDIRSKD ELGELGKSFNNMASSLRSLIHAIQDSVDNVAASSEELTASAAQTSKATEHITLAIEQF SNGNEKQNENIETAAEHIYQMNDGLTNMAQASEVITDSSVQSTEIASEGGKLVHQTVG QMNVIDKSVKEAEQVVRGLETKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIIEIVKEINTSLGMFQSVNQEVQTGLDITDK TEMSFKRISEMTNQIAGELQNMSATVQQLSASSEEVSGASEHIASISKESSAHIQDIA ASAEEQLASMEEISSSAETLSSMAEELRDMTKRFKIE*" gene complement(2899478..2901463) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" downshifts complement(2899483) /Source="Nicolas_upshifts" /id="D1618" /incds=0 /nref=196 /ntot=232 /MaxReadThrough="3.11319" /MaxDrop="7.54297" /score="40.6270404" /energy="-13.6" /TU="U2425" /idTUdmin="U2425" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(2901484..2901502) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2901499) /Source="Nicolas_upshifts" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" S_feature complement(2901501..2901588) /Source="Nicolas_S_feature" /locus_tag="new_3208192_3208279_c" /HighExp="GM 150, T0.0H, T-1.40H, T-0.40H, MG 150, T-5.40H, T-3.40H, T-1.10H, T-2.40H, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1190" promotor_-35 complement(2901516..2901523) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2901589..2903577) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871, 26522943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871, 26522943; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (membrane curvature dependent localisation)" /protein_id="NP_391003.1" /db_xref="EnsemblGenomes-Gn:BSU31250" /db_xref="EnsemblGenomes-Tr:CAB15103" /db_xref="GOA:P39216" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10860" /db_xref="UniProtKB/Swiss-Prot:P39216" /translation="MKKTLTTIRRSSIARRLIISFLLILIVPITALSVSAYQSAVASL DVQMTQSAKENVQILDHIIDDKISTTEKSLAYFSDWATAEKFQDKKKTELKQEFKQFI QMNDNVAAVFSSGKDGDFTRYPYADMPSDFNALERDWYKEAMANKGKTIVTEPYESIS SGKMVVTIARQTVDGSGVVAIDMKIDDLVTTAKGINIGKEGYAFILSQNKKVIAYSGE KAGTELKGDWVDKLYKDKSGDFEYTYKGKKKKMAFATSQTTGWKISGTMYANEIHDAA SRVLIMASIVLAIAIGAGMTAIYFVIRSITKPLRRIVASAEKISEGDLTETIEINSKD ELGVLSESFNHMAHSLRSLIHGIKDSVEHVASSSEELTASADQTSRATEHITMAIEQF SNGSESQSEKIETTTEQINEMNDGLAELARAAAVITETSADSTEVSSKGETLVQKTAG QMNTIDHSVKAAEQVVKGLEIKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIESLISEIVKEIHTSLNVLQSVNKEVETGLVMTDE TKQSFKHISQMTNQIASELQNMNATVEELSAGAQEISAASNDITAISKESSDGIQDIA ASAEEQLASMEEISSSALTLERMSEELRDLTKQFKVDK*" gene complement(2901589..2903577) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" promotor_-10 complement(2903602..2903620) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-10" upshifts complement(2903617) /Source="Nicolas_upshifts" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" promotor_-35 complement(2903634..2903641) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-35" CDS complement(2903754..2905742) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391004.2" /db_xref="EnsemblGenomes-Gn:BSU31260" /db_xref="EnsemblGenomes-Tr:CAB15104" /db_xref="GOA:P39215" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10859" /db_xref="UniProtKB/Swiss-Prot:P39215" /translation="MKTFINWLKKPSISKKLIVSFIAILIIPILILEFSSYRSASGKL DQEIMGNAKNSVDTFNTTVTNDLGEKAKAVTFFSESLKRSAFKGKSNQEEIKAKFSQY VSINQGVARIYGGADNGTYVQAPKEKLPEGYDPRQRPWYQDAMKAGGEIVVTDPYVAA SDGSMVITIAQELKDGSGVVAMDITIDKLLEQMKQIKVGKEGYAFIATKNKTYVAHKN HKAGEKLSGDWVAKMYANDSGELQYTLNNEDKKMTYTTNELTGWKIAGTMYMDEIKDA SKSVLTTGMIVLIASIVAGGILILFIVRSITKPLKRLVQSSKTISRGDLTETIEIHSK DELGELGESFNEMGQSLRSLISAIQDSVNNVAASSEQLTASAGQTSKATEHITMAIEQ FSNGNEEQSEKVESSSHQLNLMNEGLQQVSQTSSDITKASIQSTEIAGTGEKFVQQTV GQMNSINQSVQQAEAVVKGLEGKSKDITSILRVINGIADQTNLLALNAAIEAARAGES GRGFSVVAEEVRKLAVQSADSAKEIEKLIQEIVAEIDTSLHMFKEVNQEVQSGLVVTD NTKESFQSIFSMTNEIAGKLQTMNSTVEQLSDRSQHVSAAVSGIADVSKESSASIQDI AASAEEQLASMEEISSSATTLAQMAEELRDLTKQFKIE*" gene complement(2903754..2905742) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" downshifts complement(2903773) /Source="Nicolas_upshifts" /id="D1619" /incds=0 /nref=136 /ntot=224 /MaxReadThrough="3.76161" /MaxDrop="7.09773" /score="30.8363643" /energy="-10.7" /TU="U2427" /idTUdmin="U2427" /TUdmin="-132" /isTUend="FALSE" promotor_-10 complement(2905763..2905781) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2905784) /Source="Nicolas_upshifts" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" promotor_-35 complement(2905794..2905801) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2905844..2905853 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2905867..2905886 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2905870 /Source="Nicolas_upshifts" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" CDS 2905900..2906637 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /EC_number="2.3.2.13" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9692191, 16267299, 16751597, 16936016, 18249137, 26322858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9692191, 16267299, 16751597, 16936016, 18249137, 26322858; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein-glutamine gamma-glutamyltransferase (transglutaminase)" /protein_id="NP_391005.1" /db_xref="EnsemblGenomes-Gn:BSU31270" /db_xref="EnsemblGenomes-Tr:CAB15105" /db_xref="GOA:P40746" /db_xref="InterPro:IPR020916" /db_xref="PDB:4P8I" /db_xref="PDB:4PA5" /db_xref="SubtiList:BG10946" /db_xref="UniProtKB/Swiss-Prot:P40746" /translation="MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAE LMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAI RDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTET GHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFR KKGALQSAYLLSQATRLDVPSLFRIVR*" gene 2905900..2906637 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" promotor_-10 complement(2905925..2905944) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-10" upshifts complement(2905933) /Source="Nicolas_upshifts" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" promotor_-35 complement(2905960..2905964) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-35" S_feature 2906638..2909458 /Source="Nicolas_S_feature" /locus_tag="new_3213329_3216149" /HighExp="S6, S8, S7, BT, S5, C30, B36, Pyr, BC, C90" /AntisenseName="yugT" /AntisenseCor="0.63350809138227804" /AntisenseRegPval="-30.9" /CDS_PredictionProba="0.61985900000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1191" CDS complement(2906651..2906905) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097776.1" /db_xref="EnsemblGenomes-Gn:BSU31279" /db_xref="EnsemblGenomes-Tr:CAX52682" /db_xref="UniProtKB/Swiss-Prot:C0H3Q3" /translation="MNILQYSYKKRGKIEFVFEGWPHSKVTMVPIKGYYFVRFIKWSS QDPIVTRNDLEKMEWAANQYFGTAPFYRKRKAFETPSSGK*" gene complement(2906651..2906905) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" downshifts complement(2906677) /Source="Nicolas_upshifts" /id="D1620" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="2.39206" /MaxDrop="2.92958" /score="-2.51333596" /energy="-14.7" /TU="NA" /idTUdmin="U2430" /TUdmin=0 /isTUend="TRUE" S_feature complement(2906906..2907162) /Source="Nicolas_S_feature" /locus_tag="new_3213597_3213853_c" /HighExp="Etha, Sw, Salt, Gly, BC, M9-stat, Lbstat, Heat, LPhT, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37980700000000001" /TUshortSig="SigB" /TUshortPSig="0.969" /TUlongSig="NA" /TUlongPSig="NA" /label="S1192" CDS complement(2907163..2907561) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391006.2" /db_xref="EnsemblGenomes-Gn:BSU31280" /db_xref="EnsemblGenomes-Tr:CAB15106" /db_xref="InterPro:IPR001602" /db_xref="InterPro:IPR035917" /db_xref="SubtiList:BG12373" /db_xref="UniProtKB/Swiss-Prot:O05243" /translation="MLKTLQIKTTKRDEMIDITREVEAFLQETGITSGAALIYCPHTT AGITINENADPDVKKDMLRRFDEVYPWEHELDRHMEGNTAAHMKSSTVGASQHVIVEN GRLILGTWQGIYFCEFDGPRTRTCYIKMMG*" gene complement(2907163..2907561) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" CDS complement(2907521..2907655) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514000.1" /translation="MFYRVYESGLTGKKRTQNELSDESGQTKGETNAENTANQNNQTR *" gene complement(2907521..2907655) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" promotor_-10 complement(2907604..2907623) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2907611) /Source="Nicolas_upshifts" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" promotor_-35 complement(2907638..2907644) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2907681..2909345) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1761534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-1,6-glucosidase" /protein_id="NP_391007.2" /db_xref="EnsemblGenomes-Gn:BSU31290" /db_xref="EnsemblGenomes-Tr:CAB15118" /db_xref="GOA:O05242" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG12372" /db_xref="UniProtKB/Swiss-Prot:O05242" /translation="MKKAWWKEAVVYQIYPRSFKDSNGDGIGDIQGIRTKLSYIKELG ADVIWICPLYDSPNADNGYDIRDYQNILSEFGTMEDFDELLGDIHDLDMKLIMDLVVN HTSDEHPWFIESRSSIHSEKRDWYIWKDGKNGKTPNNWESIFGGPAWEYDQKTSQYYL HLFDKKQPDLNWENEKVRNAVYDMINWWLDKGIDGFRVDAITHIKKKEGFPDMPNPKG LDYVPSFPYHMNADGIMDLLTELKENTFSRYPIMTVGEANGVAAKEAADWAGEKNGIF SMIFQFEHLGLWDVEINESIDIVAFKRILTDWQDSLEGIGWNALFMENHDQPRSVSVW GDDGVYLKESAKALSAVYFLMKGTPFIYQGQELGMTNVAFPSIEDYDDVALKRLYETK TAKGTSHEDVMKIVWKKGRDNSRTPMQWNAGPYAGFSEAKPWIGINENYKWLNAEAQK NDKTSVYHFYKSLIKLRQTYDVFINGTYELILPEDQQIFAYLRKNESHTALIAANLTG TPALFRHSGLPLSSDALVLSNIETEPHKHMTSVLLKPYEARIYLWC*" gene complement(2907681..2909345) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" downshifts complement(2907697) /Source="Nicolas_upshifts" /id="D1621" /incds=0 /nref=13 /ntot=38 /MaxReadThrough="1.79723" /MaxDrop="4.64379" /score="19.4176812" /energy="-6.5" /TU="NA" /idTUdmin="U2432" /TUdmin="-7" /isTUend="TRUE" promotor_-10 complement(2908653..2908672) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2908658) /Source="Nicolas_upshifts" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2908686..2908693) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2909370..2909388) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2909387) /Source="Nicolas_upshifts" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" promotor_-35 complement(2909404..2909409) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2909472..2910761) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_391008.2" /db_xref="EnsemblGenomes-Gn:BSU31300" /db_xref="EnsemblGenomes-Tr:CAB15119" /db_xref="GOA:O05241" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12371" /db_xref="UniProtKB/Swiss-Prot:O05241" /translation="MLILQLIAIFVLIGITAVFVAAEFAIVKIRGSKINQLIESGDSR ALAAHKIISNLDEYLSACQLGITITALGLGWLGEPTFERFLHPLFTMTGIPEPFNHIV TFVVAFIIVTFLHVVMGELAPKTVSIQKAEAVSLWIAKPLIWFYKITYPFIKALNGSA SFLVKLFGFHSVKEHQVVISEEELRLILSESYEKGEINQSEFRYVNKIFEFDNRVARE IMIPRTEIAVISLEQSLEEAIHHIINERYTRYPVIKDDKDHILGIINSKDMFKAYFLG QPIKLNQIMRPVIRVIESIPVQQLLIRMQKERIHMAILVDEYGGTAGLVTVEDIIEEI VGEIRDEYDQDETPHILKKGEHHYVMDGKALIDEVNDLLDIAIENEEIDTIAGWLLTQ KMELKAGDVIHAEGCEFKILDAEDHHIRFVEIKKTDF*" gene complement(2909472..2910761) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" downshifts complement(2909481) /Source="Nicolas_upshifts" /id="D1622" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.89237" /MaxDrop="3.67001" /score="3.60520478" /energy="-7.6" /TU="NA" /idTUdmin="U2434" /TUdmin=13 /isTUend="TRUE" promotor_-35 2910290..2910296 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2910310..2910328 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2910316 /Source="Nicolas_upshifts" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" S_feature 2910320..2910972 /Source="Nicolas_S_feature" /locus_tag="new_3217011_3217663" /HighExp="Etha, Sw, Gly, Salt, BC, B60, Heat, S8, B36, HiTm" /AntisenseName="yugS" /AntisenseCor="0.12310225183111501" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1193" CDS complement(2910805..2911482) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16704729, 16850406, 24383880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent protease/peptidase" /protein_id="NP_391009.1" /db_xref="EnsemblGenomes-Gn:BSU31310" /db_xref="EnsemblGenomes-Tr:CAB15120" /db_xref="GOA:O05248" /db_xref="InterPro:IPR007395" /db_xref="SubtiList:BG12370" /db_xref="UniProtKB/Swiss-Prot:O05248" /translation="MLFIFLTIAALGLSFWAQFKVKSNFEKYSKVEASSGRTGAETAR RILDINGLYDVPVEPVRGTLTDHYDPTRRVVRLSEPVYYGRSISAISVASHEVGHALQ HQESYGALVLRHKIFPVVNFASGVAPLLFLGGMLLGSLNLIGLGIILFSAAVFFQLIT LPVEFNASSRAKQIIVSEGFIRNNEENGVNKVLSAAALTYVAAALVSLFELLRFVMIF LNGRDEN*" gene complement(2910805..2911482) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" downshifts complement(2910815) /Source="Nicolas_upshifts" /id="D1623" /incds=0 /nref=153 /ntot=249 /MaxReadThrough="3.51629" /MaxDrop="4.854" /score="33.0420688" /energy="-13" /TU="U2434,U2435" /idTUdmin="U2435" /TUdmin="-243" /isTUend="FALSE" S_feature 2911157..2911833 /Source="Nicolas_S_feature" /locus_tag="new_3217848_3218524" /HighExp="Sw, S8, Salt, BC, S7, Etha, Gly, B36, B60, LPhT" /AntisenseName="yuzI" /AntisenseCor="0.20035821815170399" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1194" promotor_-10 complement(2911517..2911536) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2911524..2911787) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16704729; Product type f : factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097777.1" /db_xref="EnsemblGenomes-Gn:BSU31319" /db_xref="EnsemblGenomes-Tr:CAX52683" /db_xref="GOA:C0H3Q4" /db_xref="UniProtKB/Swiss-Prot:C0H3Q4" /translation="MTIFQRTIVVLIGTQLAASAVILFIFDLNSYNHFSGSFSWLHFL KELAGSFAFYLFSAGLFFLLIGLCAPSRKKKRISVHEKENSLK*" gene complement(2911524..2911787) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" upshifts complement(2911538) /Source="Nicolas_upshifts" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" promotor_-35 complement(2911550..2911557) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2911799..2911817) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2911813) /Source="Nicolas_upshifts" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" promotor_-35 complement(2911833..2911838) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2911834..2912166 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15731457, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15731457, 23737939, 25297828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="atypical membrane-integrating regulator of biofilm formation (Mistic protein)" /protein_id="YP_003097778.1" /db_xref="EnsemblGenomes-Gn:BSU31321" /db_xref="EnsemblGenomes-Tr:CAX52684" /db_xref="GOA:Q5BU39" /db_xref="InterPro:IPR021078" /db_xref="PDB:1YGM" /db_xref="UniProtKB/Swiss-Prot:Q5BU39" /translation="MFCTFFEKHHRKWDILLEKSTGVMEAMKVTSEEKEQLSTAIDRM NEGLDAFIQLYNESEIDEPLIQLDDDTAELMKQARDMYGQEKLNEKLNTIIKQILSIS VSEEGEKE*" gene 2911834..2912166 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" promotor_-35 2911851..2911857 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2911872..2911889 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2911883 /Source="Nicolas_upshifts" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" CDS 2912163..2913149 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16704729, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16704729, 23737939, 25297828; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium channel protein involved in biofilm formation" /protein_id="NP_391010.3" /db_xref="EnsemblGenomes-Gn:BSU31322" /db_xref="EnsemblGenomes-Tr:CAB15121" /db_xref="GOA:Q795M8" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR013099" /db_xref="InterPro:IPR028325" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12369" /db_xref="UniProtKB/Swiss-Prot:Q795M8" /translation="MKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTS VFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQH RYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLAAPSKTVVLIDESLTEGPLIENVHF IRGHAADDGTLKRANITEAESVMITADQYKSETDADMLSVLTLLSVKGLNPLAYCIVE ILTDRFVTNAERAGANQIIGTSEFISRAMLQHYQVKLRPSKQQNGIKLTLDQHVELLA VPDELKGAAYKTCVLYFLDHNTTIIGIQKKEGPMLSPPLTYKVLETDQFLAI*" gene 2912163..2913149 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" downshifts complement(2913124) /Source="Nicolas_upshifts" /id="D1624" /incds=0 /nref=44 /ntot=128 /MaxReadThrough="0.617940000000001" /MaxDrop="4.76695" /score="21.5904825" /energy="-11.3" /TU="NA" /idTUdmin="U2437" /TUdmin=0 /isTUend="TRUE" CDS complement(2913146..2913550) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391011.1" /db_xref="EnsemblGenomes-Gn:BSU31330" /db_xref="EnsemblGenomes-Tr:CAB15122" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG12368" /db_xref="UniProtKB/Swiss-Prot:O05246" /translation="MIPIPSAIDGQSFLLQELEQVMKPLGYVINGGWEYDHGYFDYKI DDRDGYLFLRIPVNAVQGSLDERGAAVRIGTPFMLRQVFQADVDDHAEGGPFQSLFNQ FSEPERRDAEIDPAFLDIGASLVKELEDVLLH*" gene complement(2913146..2913550) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" S_feature complement(2913551..2913609) /Source="Nicolas_S_feature" /locus_tag="new_3220242_3220300_c" /HighExp="M0t90, M40t90, S6, S8, S7, T0.30H, Lbstat, M9-stat, T1.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-, SigA" /TUshortPSig="0.686, 0.141, 0.984" /TUlongSig="SigA" /TUlongPSig="0.988" /label="S1195" CDS complement(2913610..2913981) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391012.1" /db_xref="EnsemblGenomes-Gn:BSU31340" /db_xref="EnsemblGenomes-Tr:CAB15123" /db_xref="GOA:O05245" /db_xref="SubtiList:BG12367" /db_xref="UniProtKB/Swiss-Prot:O05245" /translation="MFMKQLVKHLIIAGFSAAILSFLISFDAVYTGFSSSFGGTLSHF FIHSFLLIGLPLALFTDAVHRILHLKRTHTLFTKLGLYATVVYVSWDSAVWLAAAMAV YFLIECAFFPVGRAKETTISM*" gene complement(2913610..2913981) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" CDS complement(2914040..2915392) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" gene complement(2914040..2915392) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" downshifts complement(2914051) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" promotor_-10 complement(2914207..2914225) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2914224) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" promotor_-35 complement(2914241..2914246) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2915365) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" misc_feature complement(2915368..2915379) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2915424..2915443) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2915430) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" S_feature complement(2915432..2915503) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(2915458..2915461) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2915504..2916676) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" gene complement(2915504..2916676) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" S_feature 2915839..2916760 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(2916709..2916728) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(2916722) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" promotor_-35 complement(2916745..2916748) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(2916780..2917943) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" gene complement(2916780..2917943) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" downshifts complement(2916795) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2917958..2917977) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(2917976) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" S_feature complement(2917978..2918133) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(2917992..2917999) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 2918029..2918035 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2918050..2918068 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2918060 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" S_feature 2918061..2918119 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 2918106..2918112 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2918108..2918119) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2918121 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" promotor_-10 2918126..2918137 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2918133..2918139) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2918133) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" S_feature complement(2918135..2918446) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 2918173..2918409 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" gene 2918173..2918409 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" downshifts 2918369 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" downshifts 2918435 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" CDS complement(2918487..2918879) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" gene complement(2918487..2918879) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" downshifts complement(2918491) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(2918921..2918940) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(2918928) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" S_feature complement(2918930..2919080) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(2918956..2918960) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 2918983..2918989 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2918996..2919980 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 2918996 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" promotor_-10 2919004..2919022 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2919081..2920241) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" gene complement(2919081..2920241) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" promotor_-35 2920133..2920139 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2920151 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2920153..2920157 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2920242..2920742) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" gene complement(2920242..2920742) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" promotor_-10 complement(2920772..2920791) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 2920778..2920784 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2920793) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" promotor_-10 2920799..2920810 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2920799 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" promotor_-35 complement(2920802..2920809) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 2920811..2920889 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 2920890..2921711 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" gene 2920890..2921711 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" downshifts 2921691 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" downshifts complement(2921738) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" CDS complement(2921740..2922000) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" gene complement(2921740..2922000) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" promotor_-35 2921990..2921993 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 2922008..2922027 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 2922020 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" S_feature 2922021..2922086 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(2922026..2922045) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2922031) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" promotor_-35 complement(2922057..2922063) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2922087..2923250 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" gene 2922087..2923250 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" promotor_-35 2923313..2923319 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2923331..2923350 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2923341 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" CDS 2923376..2924662 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" gene 2923376..2924662 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" S_feature complement(2924378..2925120) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 2924657..2924664 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2924678..2924697 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2924679 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" CDS 2924708..2925094 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" gene 2924708..2925094 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" downshifts 2925076 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" CDS complement(2925121..2925738) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" gene complement(2925121..2925738) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" promotor_-10 complement(2925773..2925791) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2925790) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" S_feature complement(2925792..2927880) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(2925806..2925811) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2925854..2925857 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 2925872..2925891 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 2925883 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" CDS 2925949..2927127 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" gene 2925949..2927127 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" promotor_-35 2927165..2927171 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2927183..2927202 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2927188 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" CDS 2927220..2929094 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" gene 2927220..2929094 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" promotor_-10 complement(2927860..2927879) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2927880) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" promotor_-35 complement(2927893..2927902) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2929115..2929528 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" gene 2929115..2929528 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" downshifts 2929520 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" CDS complement(2929731..2930288) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" gene complement(2929731..2930288) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" misc_feature 2929752..2929771 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2929762 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" downshifts complement(2929772) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" S_feature 2929784..2930465 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(2930314..2930333) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2930322) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" promotor_-35 complement(2930349..2930353) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2930466..2932067 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" gene 2930466..2932067 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" CDS 2932060..2932767 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" gene 2932060..2932767 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" downshifts 2932752 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" promotor_-35 2932931..2932938 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2932949..2933238 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 2932949 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" promotor_-10 2932953..2932972 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2933239..2934318 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" gene 2933239..2934318 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" CDS 2934394..2935926 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" gene 2934394..2935926 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" CDS 2935919..2936965 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" gene 2935919..2936965 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" CDS 2936966..2937925 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" gene 2936966..2937925 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" S_feature 2937926..2938047 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 2938020..2938023 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2938038..2938057 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2938049 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" CDS 2938079..2939425 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" gene 2938079..2939425 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" downshifts 2939408 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" CDS complement(2939461..2939676) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" gene complement(2939461..2939676) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" promotor_-35 2939616..2939622 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2939636..2939647 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2939640 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2939687..2939705) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2939694) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" promotor_-35 2939719..2939726 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2939721..2939726) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2939741..2939836 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 2939741..2939760 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2939741 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" promotor_-35 2939799..2939803 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2939819..2939838 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2939838..2939987 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 2939838 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" CDS 2939907..2942312 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" gene 2939907..2942312 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" CDS 2942305..2942736 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" gene 2942305..2942736 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" CDS 2942736..2943077 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" gene 2942736..2943077 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" promotor_no_box 2942968..2943068 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2943028 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" CDS 2943070..2944551 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" gene 2943070..2944551 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" S_feature complement(2943803..2945671) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 2944557..2945033 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" gene 2944557..2945033 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" CDS 2945033..2945317 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" gene 2945033..2945317 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" CDS 2945301..2945675 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" gene 2945301..2945675 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" downshifts 2945646 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" CDS complement(2945714..2946094) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" gene complement(2945714..2946094) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" downshifts complement(2945716) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" CDS complement(2946113..2946757) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" gene complement(2946113..2946757) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" S_feature complement(2946758..2946837) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(2946838..2949147) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" gene complement(2946838..2949147) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" promotor_-35 2947832..2947839 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2947853..2947872 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2947868 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 2948741..2949713 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 2948741 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" misc_feature 2948753..2948769 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2949162..2949329) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" gene complement(2949162..2949329) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" CDS complement(2949317..2950216) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKELIKECLLSYTKGDTRCKT*" gene complement(2949317..2950216) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" S_feature complement(2950217..2950330) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(2950324..2950343) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2950330) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" promotor_-35 complement(2950357..2950363) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2950401..2950541) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" gene complement(2950401..2950541) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" downshifts complement(2950430) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" S_feature complement(2950542..2950628) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(2950612..2950631) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2950628) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" promotor_-35 complement(2950645..2950651) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2950728..2950746) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2950738) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2950761..2950767) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2950763..2950888 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" gene 2950763..2950888 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" S_feature complement(2950916..2951345) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 2950941..2950946 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2950958) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" promotor_-10 2950961..2950979 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2950963 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" CDS 2951002..2951370 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" gene 2951002..2951370 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" CDS complement(2951346..2952575) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" gene complement(2951346..2952575) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" S_feature 2951371..2952684 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(2952610..2952629) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2952629) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" downshifts 2952642 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" promotor_-35 complement(2952644..2952651) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2952712..2954184) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" gene complement(2952712..2954184) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" downshifts complement(2952722) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" misc_feature 2954065..2954069 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2954072 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2954182 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" CDS complement(2954200..2954751) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" gene complement(2954200..2954751) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" promotor_-10 complement(2954773..2954792) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2954786) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" promotor_-35 complement(2954805..2954812) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2954848..2955246) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" gene complement(2954848..2955246) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" S_feature complement(2955247..2955317) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(2955318..2955566) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" gene complement(2955318..2955566) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" promotor_-10 complement(2955589..2955608) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2955600) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" promotor_-35 complement(2955624..2955627) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2955639..2955860) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" gene complement(2955639..2955860) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" downshifts complement(2955666) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" downshifts 2955854 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" promotor_-10 complement(2955878..2955897) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2955884) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" promotor_-35 complement(2955910..2955919) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2955920..2957029) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" gene complement(2955920..2957029) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" promotor_-35 2956681..2956688 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2956703..2956722 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2956712..2957106 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 2956712 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" promotor_-10 complement(2957077..2957096) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(2957093) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" S_feature complement(2957095..2957535) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 2957098..2957100 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2957108 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2957110..2957115) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 2957116..2957135 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2957144..2957533 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" gene 2957144..2957533 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" CDS complement(2957574..2957810) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" gene complement(2957574..2957810) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" downshifts complement(2957580) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2957830..2957849) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2957844) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" S_feature complement(2957846..2957986) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(2957863..2957872) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2957987..2958517) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" gene complement(2957987..2958517) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" promotor_-10 complement(2958537..2958556) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(2958548) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" S_feature complement(2958550..2958636) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(2958568..2958576) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(2958631..2958650) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2958638) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" promotor_-35 complement(2958664..2958673) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2958715..2959446) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" gene complement(2958715..2959446) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" downshifts complement(2958745) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" promotor_-10 complement(2959461..2959480) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2959472) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" promotor_-35 complement(2959495..2959502) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2959509..2959964) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" gene complement(2959509..2959964) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" promotor_-35 2959917..2959923 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2959938..2959956 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2959946..2962313 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 2959946 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" CDS complement(2959996..2963226) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" gene complement(2959996..2963226) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" CDS complement(2963223..2967710) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" gene complement(2963223..2967710) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" promotor_-35 2966985..2966991 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2967006..2967024 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2967012..2967974 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 2967012 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" CDS complement(2967771..2969126) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" gene complement(2967771..2969126) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" downshifts complement(2967792) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" CDS complement(2969141..2969380) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" gene complement(2969141..2969380) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" CDS complement(2969450..2969743) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" gene complement(2969450..2969743) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" downshifts complement(2969460) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" downshifts 2969737 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" S_feature complement(2969744..2969822) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 2969785..2969792 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2969802..2969821) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2969803 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" promotor_-10 2969807..2969824 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2969822) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" promotor_-35 complement(2969836..2969843) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2969881..2969886 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2969901..2969920 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2969913..2970019 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 2969913 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" promotor_-35 2970088..2970094 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2970108..2970127 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2970111 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 2970216..2970219 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 2970228 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" promotor_-10 complement(2970231..2970250) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2970235..2970254 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(2970253) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2970264..2971532 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" gene 2970264..2971532 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" promotor_-35 complement(2970265..2970272) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2971592..2971611 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2971597 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" CDS 2971634..2972770 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" gene 2971634..2972770 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" downshifts 2972770 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" promotor_-35 2972819..2972827 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2972837 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" promotor_-10 2972839..2972857 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2972882..2973559 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" gene 2972882..2973559 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" downshifts 2973543 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" CDS complement(2973603..2973812) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" gene complement(2973603..2973812) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" downshifts complement(2973615) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" CDS complement(2973828..2980964) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" gene complement(2973828..2980964) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" CDS complement(2980984..2981922) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" gene complement(2980984..2981922) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" CDS complement(2981950..2983569) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" gene complement(2981950..2983569) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" CDS complement(2983598..2984794) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" gene complement(2983598..2984794) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" promotor_-35 2984642..2984649 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2984664..2984683 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2984671 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2984820..2985605) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" gene complement(2984820..2985605) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" S_feature complement(2985606..2985715) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(2985710..2985729) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2985715) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" S_feature complement(2985717..2985798) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(2985743..2985750) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2985799..2986668) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" gene complement(2985799..2986668) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" S_feature complement(2986669..2986749) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(2986733..2986752) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2986749) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" promotor_-35 complement(2986766..2986773) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2986882..2987478) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" gene complement(2986882..2987478) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" S_feature complement(2987479..2987563) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 2987514..2987521 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2987531 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" promotor_-10 2987536..2987555 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2987557..2987571) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2987563) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" promotor_-35 complement(2987579..2987583) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2987579..2988181 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" gene 2987579..2988181 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" downshifts 2988167 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" CDS complement(2988251..2989579) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" gene complement(2988251..2989579) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" downshifts complement(2988267) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(2989633..2989652) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2989636) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" promotor_-35 complement(2989667..2989674) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2989726..2991228) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" gene complement(2989726..2991228) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" downshifts complement(2989741) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" misc_feature 2990793..2990807 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2990809 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2991229..2991303) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 2991251..2991258 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2991269..2991288 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2991271..2991385 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 2991271 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" misc_feature complement(2991298..2991317) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2991308) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" CDS 2991386..2991862 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" gene 2991386..2991862 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" downshifts 2991811 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" CDS complement(2991893..2992549) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" gene complement(2991893..2992549) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" downshifts complement(2991921) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" promotor_-35 2992197..2992206 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2992220..2992239 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2992237 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" S_feature 2992239..2992685 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(2992563) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" promotor_-10 complement(2992565..2992576) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2992591..2992597) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2992642 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" CDS complement(2992653..2992973) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" gene complement(2992653..2992973) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" downshifts complement(2992667) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" S_feature 2992687..2992897 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 2992839..2992939 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2992899..2993008 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 2992899 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" downshifts 2992965 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2992992..2993011) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2992997) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" S_feature 2993010..2993561 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(2993026..2993033) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2993027..2993170) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" gene complement(2993027..2993170) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" promotor_-10 complement(2993194..2993213) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2993215) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" promotor_-35 complement(2993229..2993232) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2993343..2994563) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" gene complement(2993343..2994563) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" downshifts complement(2993371) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" S_feature complement(2994564..2994691) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(2994691) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" S_feature complement(2994693..2994757) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(2994693..2994711) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2994727..2994732) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2994748..2994767) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2994756) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" promotor_-35 complement(2994782..2994789) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2994831..2994838 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2994850..2994869 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2994850 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" CDS 2994895..2995893 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" gene 2994895..2995893 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" promotor_-10 complement(2994918..2994936) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2994933) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2994953..2994958) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2995869 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" CDS complement(2995932..2996072) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" gene complement(2995932..2996072) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" downshifts complement(2995944) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" S_feature complement(2996073..2996202) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(2996183..2996202) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2996202) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" S_feature complement(2996204..2996451) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(2996216..2996222) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2996259..2996266 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2996280..2996299 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2996288 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" CDS 2996351..2997331 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" gene 2996351..2997331 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" upshifts complement(2996452) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" promotor_-10 complement(2996456..2996467) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2996481..2996487) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2997299 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" downshifts complement(2997404) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" CDS complement(2997405..2998028) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" gene complement(2997405..2998028) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" CDS complement(2998052..2998570) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" gene complement(2998052..2998570) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" misc_feature complement(2998617..2998636) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2998629) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2998631..2998739) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(2998726..2998743) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2998737) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" promotor_-35 complement(2998758..2998765) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2998893) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" CDS complement(2998908..2999270) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" gene complement(2998908..2999270) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" promotor_-10 complement(2999301..2999320) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2999311) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" promotor_-35 complement(2999334..2999341) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2999349..3000203) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" gene complement(2999349..3000203) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" promotor_-10 complement(2999919..2999938) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2999927) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" promotor_-35 complement(2999951..2999960) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3000225..3000244) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3000239) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" promotor_-35 complement(3000259..3000262) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3000326..3001540) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" gene complement(3000326..3001540) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" promotor_-35 3000875..3000881 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 3000896..3000914 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 3000903 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" S_feature 3000907..3001676 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(3001577..3001596) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(3001582) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" promotor_-35 complement(3001611..3001618) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 3001633 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" CDS complement(3001677..3001913) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" gene complement(3001677..3001913) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" S_feature 3001678..3002094 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(3001695) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" promotor_-10 complement(3001878..3001879) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3001883..3001887) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3001885) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" promotor_-10 complement(3001928..3001947) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3001929) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" promotor_-35 complement(3001961..3001968) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3002071..3002076 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 3002090..3002109 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 3002096 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" CDS 3002176..3003243 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" gene 3002176..3003243 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" downshifts 3003227 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" CDS complement(3003269..3003595) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" gene complement(3003269..3003595) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" downshifts complement(3003292) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3003627..3003646) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3003644) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" promotor_-35 complement(3003659..3003666) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3003679..3003683 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3003695..3004030 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" gene 3003695..3004030 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" promotor_-10 3003696..3003715 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3003701 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" downshifts complement(3003820) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" downshifts 3004008 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" CDS complement(3004072..3006045) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" gene complement(3004072..3006045) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" downshifts complement(3004084) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3006060..3006078) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3006083) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" promotor_-35 complement(3006090..3006098) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3006153..3007082) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" gene complement(3006153..3007082) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" downshifts complement(3006166) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" CDS complement(3007079..3008137) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" gene complement(3007079..3008137) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" CDS complement(3008137..3009438) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" gene complement(3008137..3009438) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" promotor_-35 3009323..3009332 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3009347..3009366 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3009354 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3009439..3009520) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(3009505..3009524) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3009520) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" S_feature complement(3009522..3009638) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(3009539..3009546) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3009639..3010658) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" gene complement(3009639..3010658) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" promotor_-35 3010466..3010471 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3010487..3010505 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3010491 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3010681..3010699) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3010688) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" promotor_-35 3010697..3010702 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3010715..3010720) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3010718..3010782 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 3010718..3010736 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3010718 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" promotor_-35 3010755..3010764 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3010777..3010796 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3010784 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" CDS 3010811..3011311 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" gene 3010811..3011311 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" CDS complement(3011338..3012108) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" gene complement(3011338..3012108) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" downshifts complement(3011366) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" CDS complement(3012137..3012571) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" gene complement(3012137..3012571) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" CDS complement(3012595..3012870) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" gene complement(3012595..3012870) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" promotor_-10 complement(3012890..3012909) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3012915) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" S_feature complement(3012917..3013609) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(3012923..3012930) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3012933..3012939 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3012954..3012965 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3012962 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" CDS 3012985..3013617 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" gene 3012985..3013617 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" downshifts 3013578 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" CDS complement(3013633..3014529) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" gene complement(3013633..3014529) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" downshifts complement(3013654) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" S_feature complement(3014530..3014664) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(3014651..3014670) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(3014664) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" promotor_-35 complement(3014686..3014690) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 3014704..3014710 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3014724..3014735 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3014736 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" CDS 3014764..3015744 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" gene 3014764..3015744 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" upshifts complement(3014842) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3014856..3014875) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3014892..3014895) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3015736 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" CDS complement(3015772..3016536) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" gene complement(3015772..3016536) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" downshifts complement(3015788) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3016550..3016568) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3016558) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" promotor_-35 complement(3016584..3016589) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3016609..3016914) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " gene complement(3016609..3016914) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" downshifts complement(3016617) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" promotor_-10 complement(3016928..3016947) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3016951) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" promotor_-35 complement(3016961..3016969) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3016979..3018367) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" gene complement(3016979..3018367) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" CDS complement(3018387..3019208) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" gene complement(3018387..3019208) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" CDS complement(3019226..3020074) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" gene complement(3019226..3020074) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" promotor_-35 3019593..3019598 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3019614..3019632 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3019628 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(3020085..3020104) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3020100) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" CDS complement(3020112..3020459) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" gene complement(3020112..3020459) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" promotor_-10 complement(3020472..3020491) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3020491) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" promotor_-35 complement(3020505..3020511) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3020556..3021896) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" gene complement(3020556..3021896) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" downshifts complement(3020584) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" downshifts complement(3021640) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" promotor_-35 3021953..3021959 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3021973..3021992 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3021975..3021993) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3021981 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" S_feature 3021982..3022070 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(3021992) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3022009..3022014) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3022071..3023666 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" gene 3022071..3023666 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" CDS 3023811..3025160 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " gene 3023811..3025160 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" CDS 3025166..3026458 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" gene 3025166..3026458 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" CDS 3026471..3027955 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" gene 3026471..3027955 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" CDS 3027955..3028299 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" gene 3027955..3028299 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" promotor_-35 3028021..3028024 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3028042..3028061 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3028054 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3028274 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" S_feature complement(3028315..3028702) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 3028662..3028671 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3028684..3028703 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3028687 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" ncRNA complement(3028723..3028854) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" CDS 3028723..3028854 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " gene 3028723..3028854 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" gene complement(3028723..3028854) /gene="auzJ" /locus_tag="BSU_ncRNA_2" S_feature 3028855..3028923 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 3028890 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" CDS complement(3029060..3029581) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" gene complement(3029060..3029581) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" CDS complement(3029572..3031809) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" gene complement(3029572..3031809) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" CDS complement(3031810..3032643) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" gene complement(3031810..3032643) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" CDS complement(3032640..3033257) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" gene complement(3032640..3033257) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" downshifts complement(3032749) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" CDS complement(3033254..3034246) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" gene complement(3033254..3034246) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" S_feature complement(3034247..3034333) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(3034311..3034330) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3034333) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" promotor_-35 complement(3034344..3034349) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3034475..3035725) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" gene complement(3034475..3035725) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" CDS complement(3035742..3036980) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" gene complement(3035742..3036980) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" CDS 3037203..3037340 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" gene 3037203..3037340 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" promotor_-35 3037362..3037365 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3037380..3037399 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3037381 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" CDS 3037422..3038288 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" gene 3037422..3038288 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" downshifts 3038291 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" CDS complement(3038322..3039425) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" gene complement(3038322..3039425) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" downshifts complement(3038337) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" S_feature complement(3039426..3040359) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 3039463..3039470 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3039484..3039503 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3039494 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" promotor_-35 3039545..3039551 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3039562 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" promotor_-10 3039566..3039585 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3039607..3040335 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" gene 3039607..3040335 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" CDS complement(3040360..3041214) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" gene complement(3040360..3041214) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" misc_feature complement(3040547..3040566) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3040559) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" promotor_no_box complement(3040717..3040817) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3040757) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" CDS complement(3041228..3042130) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" gene complement(3041228..3042130) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" CDS complement(3042134..3043012) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" gene complement(3042134..3043012) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" CDS complement(3043070..3044338) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" gene complement(3043070..3044338) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" promotor_no_box 3044229..3044329 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3044289 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts complement(3044409) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" CDS complement(3044419..3045405) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" gene complement(3044419..3045405) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" upshifts 3045352 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3045355..3045359 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3045448..3045467) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3045461) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" promotor_-35 complement(3045482..3045489) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3045619) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" CDS complement(3045621..3045995) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" gene complement(3045621..3045995) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" upshifts complement(3046059) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" promotor_-10 complement(3046066..3046077) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3046091..3046097) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3046098..3047216) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" gene complement(3046098..3047216) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" promotor_-10 complement(3047241..3047260) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3047247) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" S_feature complement(3047249..3047859) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(3047274..3047280) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3047313..3047322 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3047336..3047355 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3047340 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" promotor_-10 complement(3047353..3047368) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3047357) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" promotor_-35 complement(3047375..3047379) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3047375..3047521 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" gene 3047375..3047521 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" CDS 3047521..3047796 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" gene 3047521..3047796 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" upshifts complement(3047665) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3047681..3047695) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3047704..3047708) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3047776 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" CDS complement(3047860..3048243) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" gene complement(3047860..3048243) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" S_feature complement(3048244..3048353) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(3048354..3048632) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" gene complement(3048354..3048632) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" promotor_-10 complement(3048630..3048649) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3048654) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" promotor_-35 complement(3048664..3048671) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3048795..3048901) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(3048838) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" CDS complement(3048902..3050299) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" gene complement(3048902..3050299) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" downshifts 3050097 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" CDS complement(3050320..3050763) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" gene complement(3050320..3050763) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" CDS complement(3050753..3051973) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" gene complement(3050753..3051973) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" CDS complement(3051973..3053286) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" gene complement(3051973..3053286) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" CDS complement(3053304..3054089) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" gene complement(3053304..3054089) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" promotor_-10 complement(3054133..3054152) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(3054134) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" promotor_-35 complement(3054166..3054173) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(3054190..3054209) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(3054199) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" S_feature complement(3054201..3054282) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(3054225..3054229) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(3054246..3054493) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" gene complement(3054246..3054493) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" CDS complement(3054283..3054420) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" gene complement(3054283..3054420) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" S_feature complement(3054421..3054505) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(3054489..3054508) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3054505) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" S_feature complement(3054507..3054613) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(3054524..3054527) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3054614..3054991) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" gene complement(3054614..3054991) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" promotor_-10 complement(3055008..3055019) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(3055014) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" promotor_-35 complement(3055033..3055039) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(3055076..3055900) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" gene complement(3055076..3055900) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" downshifts complement(3055084) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" downshifts complement(3055233) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" promotor_-35 3055260..3055265 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3055281..3055299 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3055283 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3055914..3056582) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" gene complement(3055914..3056582) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" CDS complement(3056575..3057600) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" gene complement(3056575..3057600) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" S_feature complement(3057601..3057705) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(3057706..3057812) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene complement(3057706..3057812) /gene="mswH" /locus_tag="BSU_misc_RNA_53" downshifts 3057775 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" promotor_-10 complement(3057839..3057858) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3057851) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" S_feature complement(3057853..3057926) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(3057874..3057881) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3057927..3058271) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" gene complement(3057927..3058271) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" S_feature complement(3058272..3058377) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(3058378..3058698) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" gene complement(3058378..3058698) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" CDS complement(3058700..3059140) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" gene complement(3058700..3059140) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" CDS complement(3059140..3059376) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" gene complement(3059140..3059376) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" downshifts complement(3059152) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" upshifts complement(3059391) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" promotor_-10 complement(3059396..3059407) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3059422..3059428) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3059432..3059815) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" gene complement(3059432..3059815) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" promotor_-10 complement(3059842..3059861) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(3059853) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" promotor_-35 complement(3059874..3059881) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(3059882..3060238) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" gene complement(3059882..3060238) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" promotor_-10 complement(3060261..3060280) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(3060271) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" promotor_-35 complement(3060294..3060299) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(3060349..3062133) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" gene complement(3060349..3062133) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" downshifts complement(3060359) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" CDS complement(3062148..3063323) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " gene complement(3062148..3063323) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" CDS complement(3063334..3065703) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" gene complement(3063334..3065703) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" promotor_-35 3065122..3065127 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3065142..3065160 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3065145 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3065771..3065790) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(3065774) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" S_feature complement(3065782..3066048) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(3065804..3065811) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 3065829..3065835 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3065850..3065861 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3065872 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" CDS 3065878..3066024 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" gene 3065878..3066024 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" S_feature 3066025..3067051 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(3066049..3066957) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" gene complement(3066049..3066957) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" S_feature complement(3066958..3067480) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 3067052..3067297 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" gene 3067052..3067297 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" CDS 3067310..3067642 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" gene 3067310..3067642 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" promotor_-10 complement(3067463..3067482) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3067480) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" promotor_-35 complement(3067496..3067505) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3067631 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" promotor_-35 3067703..3067710 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3067724..3067743 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3067735 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" CDS 3067801..3068268 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" gene 3067801..3068268 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" CDS 3068265..3069890 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" gene 3068265..3069890 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" downshifts 3069875 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" CDS complement(3069926..3070309) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" gene complement(3069926..3070309) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" CDS complement(3070328..3070717) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" gene complement(3070328..3070717) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" CDS complement(3070739..3071068) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" gene complement(3070739..3071068) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" promotor_-10 complement(3071103..3071122) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3071110..3071117 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3071117) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3071132..3071151 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3071136..3071143) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3071142 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" CDS 3071202..3072089 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" gene 3071202..3072089 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" CDS complement(3072109..3072396) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" gene complement(3072109..3072396) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" downshifts complement(3072121) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" CDS complement(3072421..3073248) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " gene complement(3072421..3073248) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" downshifts complement(3072437) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" S_feature complement(3073249..3073386) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(3073371..3073390) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3073386) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" promotor_-35 complement(3073406..3073409) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3073466..3073903) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" gene complement(3073466..3073903) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" promotor_-10 complement(3073927..3073945) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(3073933) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" promotor_-35 complement(3073961..3073966) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(3074013..3075521) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" gene complement(3074013..3075521) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo downshifts complement(3074034) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" CDS complement(3075512..3075808) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" gene complement(3075512..3075808) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo promotor_-10 complement(3075831..3075850) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3075847) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" promotor_-35 complement(3075865..3075868) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3075885..3075890 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3075902..3075921 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3075902 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" CDS 3075942..3076784 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" gene 3075942..3076784 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" promotor_-35 3076314..3076320 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 3076335..3076346 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 3076343 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" promotor_-35 3076811..3076818 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3076827 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" promotor_-10 3076830..3076849 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3076874..3077335 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" gene 3076874..3077335 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" downshifts 3077311 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" CDS complement(3077379..3078755) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" gene complement(3077379..3078755) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" downshifts complement(3077387) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" S_feature complement(3078756..3078927) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(3078908..3078927) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3078927) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" promotor_-35 complement(3078938..3078945) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3078988..3079007) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 3078998..3079017 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3079000 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" upshifts complement(3079006) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" S_feature complement(3079008..3080071) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(3079022..3079029) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 3079033..3079710 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" gene 3079033..3079710 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" CDS 3079707..3081062 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" gene 3079707..3081062 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" S_feature complement(3080161..3081089) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 3081030 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" CDS complement(3081090..3081254) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" gene complement(3081090..3081254) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" promotor_-35 3081278..3081285 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3081299..3081318 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3081303..3081322) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3081309..3081421 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 3081309 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" upshifts complement(3081316) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" S_feature complement(3081318..3081596) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(3081336..3081343) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3081422..3082297 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" gene 3081422..3082297 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" promotor_-10 complement(3081586..3081605) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3081596) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" S_feature complement(3081598..3082139) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(3081619..3081626) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3082131..3082149) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3082139) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" S_feature complement(3082141..3082270) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(3082162..3082169) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3082272 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" downshifts complement(3082315) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" CDS complement(3082333..3083721) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" gene complement(3082333..3083721) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" upshifts complement(3083745) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" promotor_-10 complement(3083750..3083768) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3083779..3083787) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3083788..3083973) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" gene complement(3083788..3083973) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" downshifts 3083977 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" promotor_-10 complement(3084017..3084036) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3084026..3084032 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3084031) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" promotor_-10 3084046..3084057 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3084049 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" promotor_-35 complement(3084052..3084055) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3084091..3085539 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" gene 3084091..3085539 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" S_feature complement(3085087..3087730) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 3085508..3086605 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" gene 3085508..3086605 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" CDS 3086602..3087723 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" gene 3086602..3087723 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" CDS complement(3087731..3088366) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" gene complement(3087731..3088366) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" CDS complement(3088344..3089426) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" gene complement(3088344..3089426) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" CDS complement(3089423..3090148) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" gene complement(3089423..3090148) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" CDS complement(3090182..3091054) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" gene complement(3090182..3091054) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" promotor_-10 complement(3091073..3091092) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3091093) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" promotor_-35 complement(3091107..3091110) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3091155..3091832) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" gene complement(3091155..3091832) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" downshifts complement(3091171) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" CDS complement(3091859..3092239) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" gene complement(3091859..3092239) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" promotor_-10 complement(3092262..3092281) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3092282) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" promotor_-35 complement(3092296..3092299) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3092401..3093669) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" gene complement(3092401..3093669) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" downshifts complement(3092414) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3093703..3093722) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3093714) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" promotor_-35 complement(3093737..3093744) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3093840) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" CDS complement(3093846..3094427) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" gene complement(3093846..3094427) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" CDS complement(3094450..3095778) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" gene complement(3094450..3095778) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" CDS complement(3095778..3096839) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" gene complement(3095778..3096839) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" CDS complement(3096802..3097746) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" gene complement(3096802..3097746) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" S_feature complement(3097747..3098016) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(3097855..3097985) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" gene complement(3097855..3097985) /gene="srbL" /locus_tag="BSU_misc_RNA_85" promotor_-10 complement(3097993..3098012) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3098016) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" S_feature complement(3098018..3098945) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(3098028..3098035) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3098078..3098085 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3098100..3098119 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3098104 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" CDS 3098144..3098935 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" gene 3098144..3098935 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" downshifts 3098806 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" downshifts 3098916 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" CDS complement(3098973..3099851) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" gene complement(3098973..3099851) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" downshifts complement(3098990) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" promotor_-10 complement(3099875..3099893) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3099894) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" promotor_-35 complement(3099907..3099913) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3099923..3101665) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" gene complement(3099923..3101665) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" CDS complement(3101662..3102375) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" gene complement(3101662..3102375) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" misc_feature complement(3102406..3102425) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3102424) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" CDS complement(3102528..3102767) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" gene complement(3102528..3102767) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" downshifts complement(3102535) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" promotor_-10 complement(3102763..3102781) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3102771..3103301) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" gene complement(3102771..3103301) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" upshifts complement(3102772) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" promotor_-35 complement(3102796..3102802) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3103304..3103323) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3103311) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" CDS 3103316..3103654 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" gene 3103316..3103654 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" promotor_-35 complement(3103338..3103345) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3103354..3103373) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3103366) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" promotor_-35 complement(3103388..3103394) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 3103400..3103500 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 3103460 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" promotor_no_box 3103628..3103728 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 3103688..3103774 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 3103688 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" CDS 3103775..3104932 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" gene 3103775..3104932 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" downshifts 3104918 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" CDS 3104993..3105403 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" gene 3104993..3105403 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" downshifts 3105402 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" CDS complement(3105437..3106666) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" gene complement(3105437..3106666) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" downshifts complement(3105454) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" CDS complement(3106659..3107348) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" gene complement(3106659..3107348) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" CDS complement(3107332..3108525) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" gene complement(3107332..3108525) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" promotor_-10 complement(3108569..3108588) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3108582) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" promotor_-35 complement(3108603..3108610) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3108696..3109505) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" gene complement(3108696..3109505) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" downshifts complement(3108713) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" promotor_-35 3108852..3108861 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3108874..3108893 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3108878 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3109521..3110531) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" gene complement(3109521..3110531) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" CDS complement(3110531..3111685) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" gene complement(3110531..3111685) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" promotor_-10 complement(3111618..3111637) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3111635) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" promotor_-35 complement(3111649..3111656) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3111697..3111704 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3111719..3111738 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3111728 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" CDS 3111783..3112730 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" gene 3111783..3112730 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" downshifts 3112706 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" downshifts 3112750 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" downshifts 3112904 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" CDS complement(3112965..3114374) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" gene complement(3112965..3114374) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" downshifts complement(3112980) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" promotor_-35 3113792..3113796 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3113814..3113830 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3113821 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" S_feature 3113828..3114795 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(3114476) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" misc_RNA complement(3114478..3114657) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" gene complement(3114478..3114657) /gene="kswB" /locus_tag="BSU_misc_RNA_54" promotor_-10 complement(3114687..3114704) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3114698) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" promotor_-35 complement(3114719..3114726) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3114752 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" CDS complement(3114774..3114914) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" gene complement(3114774..3114914) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" downshifts complement(3114784) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" upshifts complement(3114942) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" S_feature complement(3114944..3115532) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(3114947..3114958) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(3114972..3114978) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 3115004..3115011 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3115025 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" promotor_-10 3115027..3115046 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3115081..3115563 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" gene 3115081..3115563 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" promotor_-35 3115577..3115584 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3115598..3115617 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3115610 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" CDS 3115663..3117516 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" gene 3115663..3117516 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" downshifts 3117502 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" CDS complement(3117544..3118470) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" gene complement(3117544..3118470) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" downshifts complement(3117556) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3118482..3118501) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3118503) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" promotor_-35 complement(3118517..3118520) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3118539..3118558 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3118548 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" CDS 3118581..3119363 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" gene 3118581..3119363 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" CDS 3119335..3120027 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" gene 3119335..3120027 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" downshifts 3120019 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" CDS complement(3120058..3120888) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" gene complement(3120058..3120888) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" downshifts complement(3120064) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" promotor_-35 3120751..3120755 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3120771..3120775 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3120780 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3120890 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" promotor_-10 complement(3120918..3120937) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3120936) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" promotor_-35 complement(3120952..3120959) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3121044..3121050 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3121064 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" promotor_-10 3121065..3121083 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3121111..3121596 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" gene 3121111..3121596 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" downshifts 3121595 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" CDS complement(3121640..3123652) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" gene complement(3121640..3123652) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" downshifts complement(3121648) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" misc_feature complement(3123318..3123322) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3123320) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3123653..3123804) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(3123781..3123799) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3123804) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" CDS complement(3123907..3125622) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" gene complement(3123907..3125622) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" downshifts complement(3123914) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" CDS complement(3125648..3127465) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" gene complement(3125648..3127465) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" promotor_-10 complement(3127507..3127526) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3127516..3127523 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3127526) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" upshifts 3127529 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3127536..3127555 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3127539..3127546) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3127636..3129960) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" gene complement(3127636..3129960) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" downshifts complement(3127654) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" promotor_-35 3129980..3129987 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3130002..3130021 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(3130003..3130018) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3130006 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(3130008) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" promotor_-10 complement(3130053..3130072) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3130062) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" promotor_-35 complement(3130088..3130094) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3130098..3130117) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3130118) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" promotor_-35 complement(3130131..3130139) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3130145) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" CDS complement(3130158..3130766) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" gene complement(3130158..3130766) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" promotor_-10 complement(3130805..3130824) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3130822) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" promotor_-35 complement(3130840..3130844) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3130953..3131369) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" gene complement(3130953..3131369) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" downshifts complement(3130963) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" CDS complement(3131374..3132042) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" gene complement(3131374..3132042) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" promotor_-10 complement(3132094..3132113) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3132109) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" downshifts complement(3132120) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" promotor_-35 complement(3132127..3132132) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3132162..3134270) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" gene complement(3132162..3134270) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" S_feature complement(3134262..3134363) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(3134357..3134376) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3134363) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" promotor_-35 complement(3134392..3134399) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3134430..3136838) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" gene complement(3134430..3136838) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" downshifts complement(3134452) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" downshifts complement(3134518) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" S_feature complement(3136839..3136921) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(3136922..3137131) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" gene complement(3136922..3137131) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" promotor_-10 complement(3137155..3137174) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(3137176) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" promotor_-35 complement(3137187..3137193) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(3137205..3137510) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " gene complement(3137205..3137510) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" misc_feature 3137474..3137493 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3137485 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3137524..3137543) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(3137550) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" promotor_-35 complement(3137557..3137563) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 3137602..3137608 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3137623..3137641 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3137631 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" CDS 3137638..3138714 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" gene 3137638..3138714 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" downshifts 3138701 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" CDS complement(3138751..3139386) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" gene complement(3138751..3139386) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" downshifts complement(3138764) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" S_feature complement(3139387..3139484) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(3139464..3139483) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3139484) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" promotor_-35 complement(3139497..3139503) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3139546..3141441) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" gene complement(3139546..3141441) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" promotor_-10 complement(3141492..3141503) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3141492) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3141518..3141524) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3141591) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" CDS complement(3141604..3142005) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" gene complement(3141604..3142005) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" CDS complement(3142002..3142361) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" gene complement(3142002..3142361) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" CDS complement(3142358..3142930) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" gene complement(3142358..3142930) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" promotor_-10 complement(3142968..3142987) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3142973) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" promotor_-35 complement(3143001..3143008) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3143041..3143835) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" gene complement(3143041..3143835) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" promotor_-10 complement(3143856..3143874) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3143868) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" promotor_-35 complement(3143889..3143895) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3143901..3143920) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3143912) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" S_feature complement(3143914..3143979) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(3143934..3143941) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(3144021..3144380) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" gene complement(3144021..3144380) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" downshifts complement(3144024) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(3144364..3144372) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3144374) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" promotor_-35 complement(3144387..3144392) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3144432..3144451) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3144440) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" S_feature complement(3144442..3144506) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(3144464..3144468) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3144506) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" promotor_-10 complement(3144507..3144526) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(3144541..3144548) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(3144557..3145027) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" gene complement(3144557..3145027) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" promotor_no_box 3144854..3144954 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3144914 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3145024 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" promotor_-10 complement(3145072..3145091) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(3145078) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" S_feature complement(3145080..3145171) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(3145107..3145110) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(3145172..3147511) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" gene complement(3145172..3147511) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" promotor_-35 3146272..3146275 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3146291..3146294 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3146300 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3147530..3148270) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" gene complement(3147530..3148270) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" promotor_-10 complement(3147926..3147944) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(3147938) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" promotor_-35 complement(3147959..3147965) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(3148298..3148316) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3148312) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" downshifts complement(3148400) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" CDS complement(3148402..3148632) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" gene complement(3148402..3148632) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" promotor_-10 complement(3148662..3148681) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(3148683) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" promotor_-35 complement(3148696..3148699) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 3148721..3148727 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3148741..3148752 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3148742 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" CDS 3148781..3149551 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" gene 3148781..3149551 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" promotor_-35 3148803..3148811 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3148822..3148840 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3148852 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3149591..3149824) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" gene complement(3149591..3149824) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" promotor_-35 3149915..3149922 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 3149930 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" promotor_-10 3149934..3149953 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 3149976..3150383 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" gene 3149976..3150383 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" CDS 3150413..3150832 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" gene 3150413..3150832 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" promotor_-35 3150870..3150877 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3150891..3150910 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3150898 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" CDS 3150924..3151250 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" gene 3150924..3151250 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" S_feature 3151251..3151335 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 3151306..3151313 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3151326..3151344 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3151337 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" CDS 3151375..3153075 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" gene 3151375..3153075 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" S_feature complement(3152091..3153084) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 3153053 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" CDS complement(3153115..3153795) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" gene complement(3153115..3153795) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" downshifts complement(3153129) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" promotor_-35 3153489..3153495 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3153510..3153528 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3153515..3156266 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 3153515 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" CDS complement(3153812..3154732) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" gene complement(3153812..3154732) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" CDS complement(3154744..3155397) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " gene complement(3154744..3155397) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" CDS complement(3155414..3156559) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" gene complement(3155414..3156559) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" S_feature complement(3156560..3156627) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(3156627) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" promotor_-10 complement(3156628..3156647) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3156658..3156662 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3156662..3156665) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3156678..3156696 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3156683 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" promotor_-35 3156778..3156782 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3156798..3156817 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3156801 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" CDS 3156843..3157376 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" gene 3156843..3157376 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" S_feature complement(3157043..3157562) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 3157365 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" promotor_-35 3157499..3157506 /Source="Nicolas_upshift_promotors" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3157519..3157597 /Source="Nicolas_S_feature" /locus_tag="new_3464210_3464288" /HighExp="T-1.10H, T2.30H, T4.0H, T5.0H, T-2.40H, T2.0H, T-0.40H, M9-stat, T-5.40H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1293" upshifts 3157519 /Source="Nicolas_upshifts" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" promotor_-10 3157521..3157540 /Source="Nicolas_upshift_promotors" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3157547..3157561) /Source="Nicolas_upshift_promotors" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3157562) /Source="Nicolas_upshifts" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" promotor_-35 complement(3157571) /Source="Nicolas_upshift_promotors" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3157598..3158074 /gene="sdpA" /locus_tag="BSU_33750" /old_locus_tag="BSU33750" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16469701, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16469701, 17069462, 23687264; Product type f: factor" /codon_start=1 /transl_table=11 /product="export step of killing factor SdpC" /protein_id="NP_391255.1" /db_xref="EnsemblGenomes-Gn:BSU33750" /db_xref="EnsemblGenomes-Tr:CAB15380" /db_xref="GOA:O34889" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG14074" /db_xref="UniProtKB/Swiss-Prot:O34889" /translation="MTICFLLFSSYYFSNISPQNPLFKKNFLQQLSPQGFGFYSKSPT EENISFHTKENLKLPNALPNNFFGIKREGRVQAIELGKIVENIDPKNWKTCENNNSCT NLEKQIKPIKVIKNEDYIHLSKGEYLIYRQKPLSWYWIDFKQTTSFERKVLKIKIV*" gene 3157598..3158074 /gene="sdpA" /locus_tag="BSU_33750" /old_locus_tag="BSU33750" promotor_-10 complement(3157623..3157642) /Source="Nicolas_upshift_promotors" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3157633) /Source="Nicolas_upshifts" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" promotor_-35 complement(3157654..3157661) /Source="Nicolas_upshift_promotors" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3158071..3159042 /gene="sdpB" /locus_tag="BSU_33760" /old_locus_tag="BSU33760" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16469701, 16850406, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16469701, 16850406, 17069462, 23687264; Product type t : transporter" /codon_start=1 /transl_table=11 /product="export step of killing factor SdpC" /protein_id="NP_391256.1" /db_xref="EnsemblGenomes-Gn:BSU33760" /db_xref="EnsemblGenomes-Tr:CAB15381" /db_xref="GOA:O34616" /db_xref="InterPro:IPR007782" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG14075" /db_xref="UniProtKB/Swiss-Prot:O34616" /translation="MKILNSLEGYIDTYNPWKNTYALFRSLLGFSTLLVLLFNSTDIL FSYSANNVTCENVYIPTAFCFAKEYSINFEIIRYLMIFILTLVVIGWRPRFTGLFHWY ICYSIQTSALTIDGGEQIATVLSFLILPVTLLDSRRNHWNIKKNNNESFTKKTVLFYI MTIIKIQVFIIYLNAALERLKNKEWAEGTAIYYFFSDPVFGLPEYQLNLMNPLLESNF IVVITWLVTIFELFLAASIISNIRIKRIALVLGILFHIGIIFSIGIVSFGLIMISALI IYLHPVQQNITMNWCSPLFKYIYVKGKRNFKRIGGESVKFLTKLFHS*" gene 3158071..3159042 /gene="sdpB" /locus_tag="BSU_33760" /old_locus_tag="BSU33760" promotor_no_box 3158879..3158979 /Source="Nicolas_upshift_promotors" /id="U2663" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.457542457542458" /psig="0.636363636363636" /xcortree=2869 /SigmaFactorBS="tcatgatatcagcattaattatatatctgcatcctgtacaac aaaatatcactatgaattggtgttctcctttatttaaatatatatatgtaaaaggaaa g" /listShort="spbC, S1297" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3158939 /Source="Nicolas_upshifts" /id="U2663" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.457542457542458" /psig="0.636363636363636" /xcortree=2869 /SigmaFactorBS="tcatgatatcagcattaattatatatctgcatcctgtacaac aaaatatcactatgaattggtgttctcctttatttaaatatatatatgtaaaaggaaa g" /listShort="spbC, S1297" /GFF_Attribute="listLong" promotor_-10 complement(3158951..3158968) /Source="Nicolas_upshift_promotors" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3158972) /Source="Nicolas_upshifts" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" S_feature complement(3158974..3159376) /Source="Nicolas_S_feature" /locus_tag="new_3465665_3466067_c" /HighExp="Gly, Lbstat, BT, S8, T1.30H, C30, M9-stat, C90, Sw, HiTm" /AntisenseName="spbC" /AntisenseCor="-0.16053929530879699" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1294" promotor_-35 complement(3158985..3158987) /Source="Nicolas_upshift_promotors" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3159003) /Source="Nicolas_upshifts" /id="D1751" /incds=0 /nref=1 /ntot=33 /MaxReadThrough="3.26001" /MaxDrop="4.09728" /score="-7.06061287" /energy="-10.3" /TU="NA" /idTUdmin="U2665" /TUdmin=286 /isTUend="FALSE" CDS 3159085..3159696 /gene="spbC" /locus_tag="BSU_33770" /old_locus_tag="BSU33770" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 16469701, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 16469701, 17069462, 23687264; Product type f: factor" /codon_start=1 /transl_table=11 /product="precursor of killing factor SdpC" /protein_id="NP_391257.1" /db_xref="EnsemblGenomes-Gn:BSU33770" /db_xref="EnsemblGenomes-Tr:CAB15382" /db_xref="GOA:O34344" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG14076" /db_xref="UniProtKB/Swiss-Prot:O34344" /translation="MKSKLLRLLIVSMVTILVFSLVGLSKESSTSAKENHTFSGEDYF RGLLFGQGEVGKLISNDLDPKLVKEANSTEGKKLVNDVVKFIKKDQPQYMDELKQSID SKDPKKLIENMTKADQLIQKYAKKNENVKYSSNKVTPSCGLYAVCVAAGYLYVVGVNA VALQTAAAVTTAVWKYVAKYSSSASNNSDLEAAAAKTLKLIHQ*" gene 3159085..3159696 /gene="spbC" /locus_tag="BSU_33770" /old_locus_tag="BSU33770" S_feature complement(3159378..3159464) /Source="Nicolas_S_feature" /locus_tag="new_3466069_3466155_c" /HighExp="T1.30H, Gly, T2.0H, BT, S8, C30, Lbstat, C90, T1.0H, M9-stat" /AntisenseName="spbC" /AntisenseCor="-5.4790207146846799E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1295" downshifts complement(3159421) /Source="Nicolas_upshifts" /id="D1752" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="4.62458" /MaxDrop="2.00358" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2665" /TUdmin="-132" /isTUend="FALSE" S_feature complement(3159466..3159651) /Source="Nicolas_S_feature" /locus_tag="new_3466157_3466342_c" /HighExp="T1.30H, T2.0H, M9-stat, T1.0H, B60, T2.30H, T5.0H, B36, T3.30H, T0.30H" /AntisenseName="spbC" /AntisenseCor="-4.2394313806342503E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1296" downshifts complement(3159509) /Source="Nicolas_upshifts" /id="D1753" /incds=1 /nref=1 /ntot=14 /MaxReadThrough="4.27088" /MaxDrop="2.27366" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2665" /TUdmin="-220" /isTUend="FALSE" downshifts 3159676 /Source="Nicolas_upshifts" /id="D1754" /incds=0 /nref=207 /ntot=252 /MaxReadThrough="4.65014" /MaxDrop="7.52715" /score="19.8036228" /energy="-20" /TU="U2660,U2663" /idTUdmin="U2660" /TUdmin="-1099" /isTUend="FALSE" downshifts complement(3159696) /Source="Nicolas_upshifts" /id="D1755" /incds=0 /nref=14 /ntot=94 /MaxReadThrough="6.14809" /MaxDrop="5.58575" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2667" /TUdmin=33 /isTUend="FALSE" S_feature 3159721..3160859 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" CDS complement(3159743..3160366) /gene="sdpI" /locus_tag="BSU_33780" /old_locus_tag="BSU33780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12817086, 15849754, 16850406, 20563570, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12817086, 15849754, 16850406, 20563570, 23687264; Product type r: regulator" /codon_start=1 /transl_table=11 /product="integral membrane immunity regulator of autophagy" /protein_id="NP_391258.1" /db_xref="EnsemblGenomes-Gn:BSU33780" /db_xref="EnsemblGenomes-Tr:CAB15383" /db_xref="GOA:O32241" /db_xref="InterPro:IPR012867" /db_xref="InterPro:IPR025962" /db_xref="InterPro:IPR026272" /db_xref="SubtiList:BG14077" /db_xref="UniProtKB/Swiss-Prot:O32241" /translation="MKKNIISIIIVCLSFLTSIILYQYLPEEIPIQWSGNKPAAIVSK PLTIFIIPVVMLIYYLTFYMLTIKSTQKNKALLFLASNNMLILLYILQLSTLLISLGY EVNIDLIIGLGVGIFLIIGGNSMQLAEQNHLIGLRTPWTLKDETVWKLGNRFASKVLV VCGFIIAVLSFFTGEYIILIMIVLVLLALVISTLASYHYYKKLNGSR*" gene complement(3159743..3160366) /gene="sdpI" /locus_tag="BSU_33780" /old_locus_tag="BSU33780" downshifts complement(3159751) /Source="Nicolas_upshifts" /id="D1756" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="6.43517" /MaxDrop="3.3455" /score="8.72167152" /energy="-11.6" /TU="U2665,U2667" /idTUdmin="U2667" /TUdmin="-22" /isTUend="TRUE" CDS complement(3160363..3160635) /gene="sdpR" /locus_tag="BSU_33790" /old_locus_tag="BSU33790" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12817086, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12817086, 17069462, 23687264; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of SdpC synthesis operon (ArsR family)" /protein_id="NP_391259.1" /db_xref="EnsemblGenomes-Gn:BSU33790" /db_xref="EnsemblGenomes-Tr:CAB15384" /db_xref="GOA:O32242" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14078" /db_xref="UniProtKB/Swiss-Prot:O32242" /translation="MNNVFKAISDPTRRKILDLLKGGDMTAGDIAEHFNISKPSISHH LNILKQAEVISDHRKGQFIYYSLNTTVLQDSINWMLNFINKGDNDL*" gene complement(3160363..3160635) /gene="sdpR" /locus_tag="BSU_33790" /old_locus_tag="BSU33790" promotor_-10 complement(3160691..3160710) /Source="Nicolas_upshift_promotors" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3160700) /Source="Nicolas_upshifts" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" S_feature complement(3160702..3160850) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" promotor_-35 complement(3160722..3160728) /Source="Nicolas_upshift_promotors" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3160855..3161544) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" gene complement(3160855..3161544) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" downshifts complement(3160895) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" promotor_-35 3161487..3161495 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3161509..3161528 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3161523 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3161562..3162473) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" gene complement(3161562..3162473) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" CDS complement(3162493..3163146) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " gene complement(3162493..3163146) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" CDS complement(3163169..3164311) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" gene complement(3163169..3164311) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" promotor_-10 complement(3164355..3164374) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(3164370) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" promotor_-35 complement(3164389..3164392) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 3164508..3164515 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3164528..3164547 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3164539 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" CDS 3164575..3165132 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" gene 3164575..3165132 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" S_feature 3165133..3165897 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(3165150..3165785) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" gene complement(3165150..3165785) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" downshifts complement(3165163) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3165826..3165844) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3165832) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" promotor_-35 complement(3165860..3165866) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3165871..3165878 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3165890..3165909 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3165899 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" CDS 3165935..3166549 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" gene 3165935..3166549 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" downshifts 3166535 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" promotor_-35 3166603..3166606 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3166621..3166640 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3166629 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" CDS 3166681..3167379 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" gene 3166681..3167379 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" downshifts 3167352 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" CDS complement(3167415..3169232) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" gene complement(3167415..3169232) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" downshifts complement(3167434) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" downshifts complement(3167605) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" misc_feature complement(3169274..3169293) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 3169278..3169297 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3169283 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" upshifts complement(3169287) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" CDS 3169352..3169819 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" gene 3169352..3169819 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" downshifts 3169816 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" CDS complement(3169864..3171156) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" gene complement(3169864..3171156) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" downshifts complement(3169874) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" CDS complement(3171186..3172721) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" gene complement(3171186..3172721) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" CDS complement(3172714..3173475) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" gene complement(3172714..3173475) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" CDS complement(3173506..3174690) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" gene complement(3173506..3174690) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" S_feature complement(3174691..3174931) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(3174931) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" S_feature complement(3174933..3175006) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(3174945..3174964) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3174980..3174984) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3175007..3176014) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" gene complement(3175007..3176014) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" promotor_-35 3175933..3175936 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3175953..3175955 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3175955 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3176061..3177083) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" gene complement(3176061..3177083) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" upshifts complement(3176077) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" promotor_-10 complement(3176085) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3176105..3176106) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3177084..3177195) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 3177121 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" promotor_-10 complement(3177176..3177195) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3177195) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" S_feature complement(3177197..3177307) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(3177209..3177216) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3177290..3177309) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(3177305) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" promotor_-35 complement(3177322..3177331) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(3177381..3178775) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" gene complement(3177381..3178775) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" downshifts complement(3177395) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3178874..3178893) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3178888) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" promotor_-35 complement(3178908..3178915) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3178915..3178922 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3178936..3178955 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3178942 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" CDS 3178979..3180067 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" gene 3178979..3180067 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" downshifts 3180047 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" CDS complement(3180116..3181126) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" gene complement(3180116..3181126) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" downshifts complement(3180123) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" S_feature complement(3181127..3181204) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(3181194..3181213) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3181204) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" promotor_-35 complement(3181227..3181234) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3181283..3182161) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" gene complement(3181283..3182161) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" promotor_-35 3181819..3181825 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3181840..3181851 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3181851 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3182195..3182202 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3182208..3182227) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(3182213) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" promotor_-10 3182216..3182235 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3182218 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" promotor_-35 complement(3182241..3182245) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 3182261..3183178 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" gene 3182261..3183178 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" downshifts 3183167 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" CDS complement(3183219..3184562) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" gene complement(3183219..3184562) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" misc_RNA complement(3184631..3184866) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" gene complement(3184631..3184866) /gene="tboX" /locus_tag="BSU_misc_RNA_56" downshifts complement(3184765) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" S_feature complement(3184867..3184963) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(3184964..3185998) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" gene complement(3184964..3185998) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" promotor_-10 complement(3186020..3186038) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3186026) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" promotor_-35 complement(3186051..3186058) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3186106..3186828) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" gene complement(3186106..3186828) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" downshifts complement(3186122) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" CDS complement(3186828..3188267) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" gene complement(3186828..3188267) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" promotor_-35 3187815..3187818 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3187835 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3187836..3187840 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 3187989 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" upshifts 3188143 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3188144..3188145 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3188294..3189010) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" gene complement(3188294..3189010) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" promotor_-35 3188914..3188921 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3188935..3188937 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3188935 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3189008 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" S_feature complement(3189011..3189077) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(3189074..3189093) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(3189077) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" promotor_-35 complement(3189108..3189115) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(3189185..3189787) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" gene complement(3189185..3189787) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" CDS complement(3189804..3190919) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" gene complement(3189804..3190919) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" CDS complement(3190923..3191660) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" gene complement(3190923..3191660) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" promotor_-10 complement(3190949..3190968) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(3190963) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" promotor_-35 complement(3190980..3190987) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(3191661..3192566) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" gene complement(3191661..3192566) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" promotor_-10 complement(3192586..3192604) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3192597) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3192620..3192623) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3192775..3192782 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3192793..3192812 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3192800 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" CDS 3192850..3193659 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" gene 3192850..3193659 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" CDS 3193695..3194906 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" gene 3193695..3194906 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" downshifts 3194893 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" CDS complement(3194960..3196249) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" gene complement(3194960..3196249) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" CDS complement(3196329..3198392) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" gene complement(3196329..3198392) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" CDS complement(3198411..3199262) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" gene complement(3198411..3199262) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" CDS complement(3199266..3200522) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" gene complement(3199266..3200522) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" CDS complement(3200562..3201827) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" gene complement(3200562..3201827) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" promotor_-10 complement(3201859..3201878) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3201881) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" promotor_-35 complement(3201893..3201900) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3201968..3202960) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" gene complement(3201968..3202960) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" downshifts complement(3202002) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" S_feature complement(3203090..3203139) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(3203113) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" CDS complement(3203140..3203799) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" gene complement(3203140..3203799) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" S_feature complement(3203800..3203905) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(3203897..3203916) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3203906) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" promotor_-35 complement(3203931..3203934) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3203958..3203965 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3203980..3203999 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3203980 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" S_feature 3203983..3204088 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(3203989..3204006) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3203993) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3204014..3204020) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3204089..3205780 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" gene 3204089..3205780 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" downshifts 3205765 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" CDS complement(3205807..3207117) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" gene complement(3205807..3207117) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" S_feature 3205810..3206880 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(3205819) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" misc_feature 3206937..3206956 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3206937..3207195 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 3206937 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" promotor_-10 complement(3207131..3207150) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3207146) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" promotor_-35 complement(3207165..3207168) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3207196..3207414 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" gene 3207196..3207414 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" downshifts 3207393 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" CDS complement(3207424..3208392) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1097084, 115661000, 20720312, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvyl transferase for matrix biofilm formation" /protein_id="NP_391302.1" /db_xref="EnsemblGenomes-Gn:BSU34220" /db_xref="EnsemblGenomes-Tr:CAB15427" /db_xref="GOA:P71065" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11874" /db_xref="UniProtKB/Swiss-Prot:P71065" /translation="MDSKHSMISLKQKLSGLLDVIPKQSEIIYADYPLYGNVGDLFIM KGTEAFFKEHGIRVRKRWNPDNFPIGRKLDPNLIIVCQGGGNFGDLYPYYQGFREKIV QTYPNHKIVILPQSIYFQNKDNLKRTAEIFSKHANLHIMTREKASYATAQAYFTTNHI QLLPDMAHQLFPVIPTQQPSNQKLRFIRTDHEANQALQEHAEAESYDWRTVLSASDRR TIAFLQTLNVLNKKAGNPLPIAYIWEKYSDYIVQKAIRFFSRYESVETSRLHGHILSS LLQKENTVIDNSYGKNANYFHTWMEGVPSTRLIQHASKKENLPAHM*" gene complement(3207424..3208392) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" CDS complement(3208371..3209537) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" /EC_number="2.6.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 23378512, 27084765, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase involved in biofilm matrix formation" /protein_id="NP_391303.2" /db_xref="EnsemblGenomes-Gn:BSU34230" /db_xref="EnsemblGenomes-Tr:CAB15428" /db_xref="GOA:Q795J3" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11873" /db_xref="UniProtKB/Swiss-Prot:Q795J3" /translation="MHKKIYLSPPHMSGREQHYISEAFRSNWIAPLGPLVNSFEEQLA ERVGVKAAAAVGSGTAAIHLALRLLEVKEGDSVFCQSFTFVATANPILYEKAVPVFID SEPDTWNMSPTALERALEEAKRNGTLPKAVIAVNLYGQSAKMDEIVSLCDAYGVPVIE DAAESLGTVYKGKQSGTFGRFGIFSFNGNKIITTSGGGMLVSNDEAAIEKARFLASQA REPAVHYQHSEIGHNYRLSNILAGVGIAQLEVLDERVEKRRTIFTRYKNALGHLDGVR FMPEYAAGVSNRWLTTLTLDNGLSPYDIVQRLAEENIEARPLWKPLHTQPLFDPALFY SHEDTGSVCEDLFKRGICLPSGSNMTEDEQGRVIEVLLHLFHTVEVKKWTASIR*" gene complement(3208371..3209537) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" CDS complement(3209542..3210192) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative O-acetyltransferase involved in biofilmmatrix formation" /protein_id="NP_391304.1" /db_xref="EnsemblGenomes-Gn:BSU34240" /db_xref="EnsemblGenomes-Tr:CAB15429" /db_xref="GOA:P71063" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR020019" /db_xref="SubtiList:BG11872" /db_xref="UniProtKB/Swiss-Prot:P71063" /translation="MKNVAIVGDGGHGKVIRELINARSDTRLAAVLDDKFKTFEGGKE WYTGPPKAVTELRRLIPDVLFLIAVGNNSVRKQLAERLGLGKDDFITLIHPSAIVSKS AVIGEGTVIMAGAIIQADARIGAHCIINTGAVAEHDNQISDYVHLSPRATLSGAVSVQ EGAHVGTGASVIPQIIIGAWSIVGAGSAVIRSIPDRVTAAGAPARIISSIQTSNKG*" gene complement(3209542..3210192) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" CDS complement(3210189..3210797) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" /EC_number="2.7.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase involved in extracellular matrix synthesis" /protein_id="NP_391305.1" /db_xref="EnsemblGenomes-Gn:BSU34250" /db_xref="EnsemblGenomes-Tr:CAB15430" /db_xref="GOA:P71062" /db_xref="InterPro:IPR003362" /db_xref="SubtiList:BG11871" /db_xref="UniProtKB/Swiss-Prot:P71062" /translation="MILKRLFDLTAAIFLLCCTSVIILFTIAVVRLKIGSPVFFKQVR PGLHGKPFTLYKFRTMTDERDSKGNLLPDEVRLTKTGRLIRKLSIDELPQLLNVLKGD LSLVGPRPLLMDYLPLYTEKQARRHEVKPGITGWAQINGRNAISWEKKFELDVWYVDN WSFFLDLKILCLTVRKVLVSEGIQQTNHVTAERFTGSGDVSS*" gene complement(3210189..3210797) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" CDS complement(3210794..3212311) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 15849754, 16850406, 26078454, 27897378; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative extracellular matrix component exporter; putative cyclic di-GMP receptor" /protein_id="YP_003097789.1" /db_xref="EnsemblGenomes-Gn:BSU34265" /db_xref="EnsemblGenomes-Tr:CAX52695" /db_xref="GOA:P71060" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="UniProtKB/Swiss-Prot:P71060" /translation="MKFTINFSANLTAFLLSVFLSVWMTPFIVKTLGVEAFGFVHLTQ NVINYFSVITVALSSVVVRFFSVAAHRGEREKANAYISNYLAASVLISLLLLLPLAGS AFFIDRVMNVPQALLADVRLSILIGSVLFILTFLMAGFGAAPFYANRLYITSSIQAVQ MLIRVLSVLLLFACFAPKIWQIQLAALAGAVIASVLSFYFFKKLIPWFSFRMKDLSFR TSKELFQAGAWSSVNQIGVLLFLQIDLLTANLMLGASASGKYAAIIQFPLLLRSLAGT VASLFAPIMTSYYSKGDMEGLMNYANKAVRLNGLLLALPAALLGGLAGPFLTIWLGPS FSTIAPLLFIHAGYLVVSLAFMPLFYIWTAFNQQKTPAIVTLLLGAVNVVLAVTLSGP AHLGLYGITLAGAISLILKNAIFTPLYVSRITGYKKHVFLKGIIGPLSAAVFAWTVCK AIQFIVKIDSWPSLIATGVTVSFCYAVFAFMLVCTKEERQLVLKRFRKTKGAVNL*" gene complement(3210794..3212311) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" CDS complement(3212308..3213342) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 26078454, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase involved in biofilm matrix formation" /protein_id="NP_391308.1" /db_xref="EnsemblGenomes-Gn:BSU34280" /db_xref="EnsemblGenomes-Tr:CAB15433" /db_xref="GOA:P71059" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11868" /db_xref="UniProtKB/Swiss-Prot:P71059" /translation="MIPLVSIIVPMYNVEPFIEECIDSLLRQTLSDIEIILVNDGTPD RSGEIAEDYAKRDARIRVIHQANGGLSSARNTGIKAARGTYIGFVDGDDYVSSAMFQR LTEEAEQNQLDIVGCGFYKQSSDRRTYVPPQLEANRVLTKPEMTEQLKHAHETRFIWY VWRYLYRRELFERANLLFDEDIRFAEDSPFNLSAFREAERVKMLDEGLYIYRENPNSL TEIPYKPAMDEHLQKQYQAKIAFYNHYGLAGACKEDLNVYICRHQLPMLLANACASPN SPKDIKKKIRQILSYDMVRQAVRHTPFQHEKLLRGERLVLALCKWRLTFLIKLFFEQR GTMKGSAKQA*" gene complement(3212308..3213342) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" CDS complement(3213339..3214415) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15173185, 15661000, 20720312, 26078454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide pyruvyl transferase involved in biofilm matrix formation" /protein_id="NP_391309.1" /db_xref="EnsemblGenomes-Gn:BSU34290" /db_xref="EnsemblGenomes-Tr:CAB15434" /db_xref="GOA:P71058" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11867" /db_xref="UniProtKB/Swiss-Prot:P71058" /translation="MSLQSLKINFAEWLLLKVKYPSQYWLGAADQPVKAAAHQKKIIL TLLPSHDNLGDHAIAYASKAFLEQEYPDFDIVEVDMKDIYKSAKSLIRSRHPEDMVFI IGGGNMGDLYRYEEWTRRFIIKTFHDYRVVQLPATAHFSDTKKGRKELKRAQKIYNAH PGLLLMARDETTYQFMKQHFQEKTILKQPDMVLYLDRSKAPAEREGVYMCLREDQESV LQEEQRNRVKAALCEEFGEIKSFTTTIGRRVSRDTREHELEALWSKLQSAEAVVTDRL HGMIFCALTGTPCVVIRSFDHKVMEGYQWLKDIPFMKLIEHPEPERVTAAVNELLTKE TSRAGFPRDVYFKGLRDKISGEAQ*" gene complement(3213339..3214415) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" CDS complement(3214420..3215454) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15083514, 15661000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in biofilmformation" /protein_id="NP_391310.1" /db_xref="EnsemblGenomes-Gn:BSU34300" /db_xref="EnsemblGenomes-Tr:CAB15435" /db_xref="GOA:P71057" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11866" /db_xref="UniProtKB/Swiss-Prot:P71057" /translation="METPAVSLLVAVYNTETYIRTCLESLRNQTMDNIEIIIVNDGSA DASPDIAEEYAKMDNRFKVIHQENQGLGAVRNKGIEAARGEFIAFIDSDDWIEPDYCE QMLRTAGDETDLVICNYAAEFEDTGKTMDSDIAQTYQDQPKEHYIKALFEGKVRGFSW NKLYRRSMIEAHRLSFPLRGELEHVEDQFFSFRAHFFARSVSYVKTPLYHYRIHLSSI VQRYQKKLFESGLALYETNAAFLQENNKLEEYRKELDTFIVLHSSICMLNEWKTSGSR RLFEKLRNVGVICADPVFQESLSKTGTAPFDAKRSCLLLMAKYRMIPFVAMASAVYQR VIEYKMRNRG*" gene complement(3214420..3215454) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" CDS complement(3215479..3216582) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 15849754, 16850406, 22451411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 15849754, 16850406, 22451411; Product type f: factor" /codon_start=1 /transl_table=11 /product="biofilm extracellular matrix formation chain-length determining factor" /protein_id="NP_391311.1" /db_xref="EnsemblGenomes-Gn:BSU34310" /db_xref="EnsemblGenomes-Tr:CAB15436" /db_xref="GOA:P71056" /db_xref="SubtiList:BG11865" /db_xref="UniProtKB/Swiss-Prot:P71056" /translation="MIVYAVNMGIVFIWSWFAKMCGGRDDSLATGYRPNKLLIWIPLA SLVLVSGLRYRVGTDFQTYTLLYELAGDYQNVWQIFGFGTAKTATDPGFTALLWLMNF ITEDPQIMYFTVAVVTYSFIMKTLADYGRPFELSVFLFLGTFHYYASFNGIRQYMVAA VLFWAIRYIISGNWKRYFLIVLVSSLFHSSALIMIPVYFIVRRKAWSPAIFGLSALFL GMTFLYQKFISVFVVVLENSSYSHYEKWLMTNTNGMNVIKIAVLVLPLFLAFCYKERL RSLWPQIDIVVNLCLLGFLFGLLATKDVIFARFNIYFGLYQMILVPYFVRIFDEKSNA LIYIAIVVCYFLYSYLLMPVDSSVLPYRTIFSR*" gene complement(3215479..3216582) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" CDS complement(3216579..3217733) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" /EC_number="2.-.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 22451411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in matrix formation (chain-length determination)" /protein_id="NP_391312.1" /db_xref="EnsemblGenomes-Gn:BSU34320" /db_xref="EnsemblGenomes-Tr:CAB15437" /db_xref="GOA:P71055" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11864" /db_xref="UniProtKB/Swiss-Prot:P71055" /translation="MNSSQKRVLHVLSGMNRGGAETMVMNLYRKMDKSKVQFDFLTYR NDPCAYDEEILSLGGRLFYVPSIGQSNPLTFVRNVRNAIKENGPFSAVHAHTDFQTGF IALAARLAGVPVRVCHSHNTSWKTGFNWKDRLQLLVFRRLILANATALCACGEDAGRF LFGQSNMERERVHLLPNGIDLELFAPNGQAADEEKAARGIAADRLIIGHVARFHEVKN HAFLLKLAAHLKERGIRFQLVLAGDGPLCGEIEEEARQQNLLSDVLFLGTEERIHELM RTFDVFVMPSLYEGLPVVLVEAQASGLPCIISDSITEKVDAGLGLVTRLSLSEPISVW AETIARAAAAGRPKREFIKETLAQLGYDAQQNVGALLNVYNISTEKDHNR*" gene complement(3216579..3217733) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" CDS complement(3217726..3218562) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 21170308, 22720735, 23480406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 21170308, 22720735, 23480406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional flagellar clutch and glycosyltransferase acting during biofilm formation" /protein_id="NP_391313.2" /db_xref="EnsemblGenomes-Gn:BSU34330" /db_xref="EnsemblGenomes-Tr:CAB15438" /db_xref="GOA:P71054" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11863" /db_xref="UniProtKB/Swiss-Prot:P71054" /translation="MNSGPKVSVIMGIYNCERTLAESIESILSQSYKNWELILCDDAS TDGTLRIAKQYAAHYSDRIKLIQNKTNKRLAASLNHCLSHATGDYIARQDGDDLSFPR RLEKQVAFLEKHRHYQVVGTGMLVFDEFGVRGARILPSVPEPGIMAKGTPFCHGTIMM RASAYRTLKGYRSVRRTRRMEDIDLWLRFFEEGFRGYNLQEALYKVREDSDAFKRRSF TYSIDNAILVYQACRRLKLPLSDYIYIAKPLIRAFMPAAVMNRYHKKRVMNQKEGLVK HE*" gene complement(3217726..3218562) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" CDS complement(3218559..3219704) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512, 26299781; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative extracellular matrix glycosyltransferase" /protein_id="NP_391314.1" /db_xref="EnsemblGenomes-Gn:BSU34340" /db_xref="EnsemblGenomes-Tr:CAB15439" /db_xref="GOA:P71053" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11862" /db_xref="UniProtKB/Swiss-Prot:P71053" /translation="MTKKILFCATVDYHFKAFHLPYFKWFKQMGWEVHVAANGQTKLP YVDEKFSIPIRRSPFDPQNLAVYRQLKKVIDTYEYDIVHCHTPVGGVLARLAARQARR HGTKVLYTAHGFHFCKGAPMKNWLLYYPVEKWLSAYTDCLITINEEDYIRAKGLQRPG GRTQKIHGIGVNTERFRPVSPIEQQRLREKHGFREDDFILVYPAELNLNKNQKQLIEA AALLKEKIPSLRLVFAGEGAMEHTYQTLAEKLGASAHVCFYGFCSDIHELIQLADVSV ASSIREGLGMNVLEGMAAEQPAIATDNRGHREIIRDGENGFLIKIGDSAAFARRIEQL YHKPELCRKLGQEGRKTALRFSEARTVEEMADIYSAYMDMDTKEKSV*" gene complement(3218559..3219704) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" CDS complement(3219716..3221512) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" /EC_number="5.1.3.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 23378512, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-sugar epimerase involved in biofilmmatrix formation" /protein_id="NP_391315.1" /db_xref="EnsemblGenomes-Gn:BSU34350" /db_xref="EnsemblGenomes-Tr:CAB15440" /db_xref="GOA:P71052" /db_xref="InterPro:IPR003869" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11861" /db_xref="UniProtKB/Swiss-Prot:P71052" /translation="MIIALDTYLVLNSVIAGYQFLKDSYQFYDSGALLLTAVSLLLSY HVCAFLFNQYKQVWTYTGLGELIVLLKGITLSAAVTGVIQYAVYHTMFFRLLTACWVL QLLSIGGTRILSRVLNESIRKKRCASSRALIIGAGSGGTLMVRQLLSKDEPDIIPVAF IDDDQTKHKLEIMGLPVIGGKESIMPAVQKLKINYIIIAIPSLRTHELQVLYKECVRT GVSIKIMPHFDEMLLGTRTAGQIRDVKAEDLLGRKPVTLDTSEISNRIKGKTVLVTGA GGSIGSEICRQISAFQPKEIILLGHGENSIHSIYTELNGRFGKHIVFHTEIADVQDRD KMFTLMKKYEPHVVYHAAAHKHVPLMEHNPEEAVKNNIIGTKNVAEAADMSGTETFVL ISSDKAVNPANVMGATKRFAEMIIMNLGKVSRTKFVAVRFGNVLGSRGSVIPIFKKQI EKGGPVTVTHPAMTRYFMTIPEASRLVIQAGALAKGRQIFVLDMGEPVKIVDLAKNLI HLSGYTTEQVPIEFTGIRPGEKMYEELLNKNEVHAEQIFPKIHIGKAVDGDWPVLMRF IEDFHELPEADLRARLFAAINTSEEMTAASVH*" gene complement(3219716..3221512) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" S_feature complement(3221513..3221572) /Source="Nicolas_S_feature" /locus_tag="new_3528204_3528263_c" /HighExp="LoTm, G/S, M9-tran, BMM, MG 150, S3, S2, S4, aero, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.79" /TUlongSig="NA" /TUlongPSig="NA" /label="S1312" promotor_-10 complement(3221546..3221564) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3221572) /Source="Nicolas_upshifts" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" promotor_-35 complement(3221578..3221584) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3221771..3222454) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" /EC_number="2.7.10.2" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 15741737, 24493247, 26283769, 28950882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 15741737, 24493247, 26283769, 28950882; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine kinase involved in biofilm matrix formation" /protein_id="NP_391316.1" /db_xref="EnsemblGenomes-Gn:BSU34360" /db_xref="EnsemblGenomes-Tr:CAB15441" /db_xref="GOA:P71051" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11860" /db_xref="UniProtKB/Swiss-Prot:P71051" /translation="MIFRKKKARRGLAQISVLHNKSVVAEQYRTIRTNIEFSSVQTNL RSILVTSSVPGEGKSFSAANLAAVFAQQQEKKVLLVDADLRKPTINQTFQVDNVTGLT NVLVGNASLSETVQKTPIDNLYVLTSGPTPPNPAELLSSKAMGDLISEIYEQFSLVIF DSPPLLAVADAQILANQTDGSVLVVLSGKTKTDTVLKAKDALEQSNAKLLGALLNKKK MKKSEHYSY*" gene complement(3221771..3222454) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" CDS complement(3222460..3223164) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12970183, 15661000, 23378512, 26283769, 28950882; Product type r : regulator" /codon_start=1 /transl_table=11 /product="modulator of protein tyrosine kinase EpsB involved in biofilm matrix formation" /protein_id="NP_391317.1" /db_xref="EnsemblGenomes-Gn:BSU34370" /db_xref="EnsemblGenomes-Tr:CAB15442" /db_xref="GOA:P71050" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG11859" /db_xref="UniProtKB/Swiss-Prot:P71050" /translation="MNENMSFKELYAIVRHRFVLILLITIGVTLIMGFVQFKVISPTY QASTQVLVHESDGEENSNLSDIQRNLQYSSTFQSIMKSTALMEEVKAELHLSESASSL KGKVVTSSENESEIINVAVQDHDPAKAAEIANTLVNKFEKEVDERMNVQGVHILSEAK ASESPMIKPARLRNMVMAFGAAVMGGITLAFFLHFLDDTCKSARQLSERTGLPCLGSV PDVHKGRNRGIKHFGE*" gene complement(3222460..3223164) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" promotor_-35 3223129 /Source="Nicolas_upshift_promotors" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3223146 /Source="Nicolas_upshifts" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" promotor_-10 3223149..3223167 /Source="Nicolas_upshift_promotors" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3223165..3223222) /Source="Nicolas_S_feature" /locus_tag="new_3529856_3529913_c" /HighExp="LoTm, BT, S3, G/S, BMM, M9-tran, S4, aero, T1.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.952" /TUlongSig="NA" /TUlongPSig="NA" /label="S1313" promotor_-10 complement(3223218..3223237) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3223223) /Source="Nicolas_upshifts" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" promotor_-35 complement(3223251..3223258) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3223340..3223345 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-35" promotor_-10 3223360..3223379 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-10" upshifts 3223366 /Source="Nicolas_upshifts" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" CDS 3223410..3223868 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" /function="16.5: Explore" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18430133, 18647168, 20923420, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18430133, 18647168, 20923420, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of autolysin genes (biofilm formation)" /protein_id="NP_391318.1" /db_xref="EnsemblGenomes-Gn:BSU34380" /db_xref="EnsemblGenomes-Tr:CAB15443" /db_xref="GOA:P71049" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="SubtiList:BG11858" /db_xref="UniProtKB/Swiss-Prot:P71049" /translation="MIGRIIRLYRKRKGYSINQLAVESGVSKSYLSKIERGVHTNPSV QFLKKVSATLEVELTELFDAETMMYEKISGGEEEWRVHLVQAVQAGMEKEELFTFTNR LKKEQPETASYRNRKLTESNIEEWKALMAEAREIGLSVHEVKSFLKTKGR*" gene 3223410..3223868 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" promotor_-35 3223890..3223893 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3223899 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" promotor_-10 3223910..3223928 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3223944..3225413 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" gene 3223944..3225413 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" downshifts 3225390 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" CDS 3225416..3225607 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" gene 3225416..3225607 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" downshifts 3225586 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" CDS complement(3225634..3226119) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" gene complement(3225634..3226119) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" CDS complement(3226142..3226453) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" gene complement(3226142..3226453) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo CDS complement(3226505..3226597) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" gene complement(3226505..3226597) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo promotor_-10 complement(3226637..3226656) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3226654) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" promotor_-35 complement(3226670..3226677) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3226728..3227411) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" gene complement(3226728..3227411) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" downshifts complement(3226746) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" CDS complement(3227427..3228782) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" gene complement(3227427..3228782) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" promotor_-10 complement(3228794..3228809) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3228810) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" promotor_-35 complement(3228821..3228830) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3229084..3229091 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3229105..3229124 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3229108 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" S_feature 3229130..3229320 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 3229321..3230742 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" gene 3229321..3230742 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" downshifts 3230736 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" CDS 3230816..3232366 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" gene 3230816..3232366 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" promotor_-35 3232410..3232416 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3232430..3232441 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3232430 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" CDS 3232474..3234036 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" gene 3232474..3234036 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" downshifts 3234014 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" CDS 3234026..3234715 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" gene 3234026..3234715 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" promotor_-35 3234065..3234072 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3234086..3234105 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3234095 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" downshifts 3234696 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" downshifts complement(3234794) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" CDS 3234797..3235132 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" gene 3234797..3235132 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" CDS 3235132..3235452 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" gene 3235132..3235452 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" S_feature 3235453..3235643 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(3235488..3236000) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" gene complement(3235488..3236000) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" downshifts 3235620 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3236036..3236047) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3236042) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" promotor_-35 complement(3236062..3236068) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3236115..3236251) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(3236158) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" CDS complement(3236252..3237595) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" gene complement(3236252..3237595) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" promotor_-10 complement(3237624..3237643) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3237632) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" promotor_-35 complement(3237656..3237665) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3237657..3237662 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3237678..3237696 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3237681 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3237890..3237899 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3237908 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" promotor_-10 3237913..3237932 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3237951..3238913 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" gene 3237951..3238913 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" S_feature 3238914..3239167 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(3239194) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" tRNA complement(3239198..3239273) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3239198..3239273) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" promotor_-10 complement(3239300..3239319) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3239321) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" promotor_-35 complement(3239335..3239338) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3239404..3239410 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3239420..3239495 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 3239420 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" promotor_-10 3239425..3239444 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3239472..3239479 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3239493..3239512 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3239497 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" CDS 3239543..3240136 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" gene 3239543..3240136 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" downshifts 3240125 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" S_feature 3240170..3240568 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(3240182..3240862) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" gene complement(3240182..3240862) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" downshifts complement(3240206) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" CDS complement(3240859..3242544) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" gene complement(3240859..3242544) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" CDS complement(3242537..3244810) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" gene complement(3242537..3244810) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" CDS complement(3244788..3245672) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" gene complement(3244788..3245672) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" CDS complement(3245678..3246514) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" gene complement(3245678..3246514) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" CDS complement(3246515..3247822) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" gene complement(3246515..3247822) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" promotor_-35 3246880..3246889 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3246902..3246921 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3246906 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3247862..3249115) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" gene complement(3247862..3249115) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" S_feature complement(3249116..3249210) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(3249211..3250980) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" gene complement(3249211..3250980) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" promotor_-35 3250901..3250906 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3250922..3250940 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3250932 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3251018..3251037) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3251031) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" promotor_-35 complement(3251050..3251057) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3251093..3252043) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" gene complement(3251093..3252043) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" promotor_-10 complement(3252058..3252076) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3252071) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3252088..3252096) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3252177) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" CDS complement(3252249..3252824) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" gene complement(3252249..3252824) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" downshifts complement(3252261) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" promotor_-10 complement(3252867..3252886) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3252873..3252880 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3252883) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" upshifts 3252890 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" promotor_-10 3252893..3252912 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3252901..3252908) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3252941..3253261 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" gene 3252941..3253261 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" downshifts 3253242 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" downshifts complement(3253288) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" CDS complement(3253288..3254880) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" gene complement(3253288..3254880) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" CDS complement(3254899..3255492) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" gene complement(3254899..3255492) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" promotor_-10 complement(3255534..3255553) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3255547) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" promotor_-35 complement(3255568..3255572) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3255618..3255623 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3255639..3255657 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3255640 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" promotor_-35 3255813..3255820 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3255834..3255853 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3255838 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" CDS 3255875..3256852 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" gene 3255875..3256852 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" downshifts 3256824 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" CDS complement(3256890..3258830) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" gene complement(3256890..3258830) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" downshifts complement(3256914) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" CDS complement(3258805..3259584) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" gene complement(3258805..3259584) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" S_feature complement(3259585..3259666) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(3259667..3260737) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" gene complement(3259667..3260737) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" CDS complement(3260731..3261444) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" gene complement(3260731..3261444) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" promotor_-10 complement(3261490..3261509) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3261502) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" S_feature complement(3261504..3261765) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(3261522..3261525) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3261525..3261532 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3261543..3261562 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3261548 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" CDS 3261591..3261800 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" gene 3261591..3261800 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" downshifts 3261778 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" downshifts complement(3261810) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" CDS complement(3261836..3262600) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" gene complement(3261836..3262600) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" downshifts complement(3261858) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" CDS complement(3262601..3262858) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" gene complement(3262601..3262858) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" CDS complement(3262882..3263832) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" gene complement(3262882..3263832) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" CDS complement(3263855..3264808) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" gene complement(3263855..3264808) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" CDS complement(3264810..3265697) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" gene complement(3264810..3265697) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" CDS complement(3265722..3266198) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" gene complement(3265722..3266198) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" promotor_-10 complement(3266218..3266237) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3266232) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" promotor_-35 complement(3266253..3266257) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3266276..3266295) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3266289) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" promotor_-35 complement(3266310..3266313) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3266365..3266515) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(3266408) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" CDS complement(3266516..3267466) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" gene complement(3266516..3267466) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" S_feature complement(3267467..3267554) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(3267543..3267562) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3267554) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" S_feature complement(3267556..3267647) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(3267577..3267580) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3267595..3267601 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3267615..3267633 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3267629 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" S_feature 3267630..3271016 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(3267672..3269093) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" gene complement(3267672..3269093) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" downshifts complement(3267692) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" downshifts complement(3267816) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" misc_feature 3268720..3268724 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3268730 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3269009..3269013 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3269016 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3269094..3269291) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 3269214 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" promotor_-10 complement(3269279..3269298) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(3269291) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" promotor_-35 complement(3269310..3269317) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(3269474..3270928) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" gene complement(3269474..3270928) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" downshifts complement(3269494) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" S_feature complement(3270929..3271053) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 3270974 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" CDS complement(3271054..3272823) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" gene complement(3271054..3272823) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" S_feature complement(3272824..3272898) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(3272887..3272906) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3272898) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" CDS complement(3272988..3273347) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" gene complement(3272988..3273347) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" downshifts complement(3273008) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" CDS complement(3273362..3275272) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" gene complement(3273362..3275272) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" CDS complement(3275274..3275999) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /translation="MKKIIFICFSLLLALTGGCSMNDNDKNSTNDNKTEAVKPKDMDP KDLPQVPAFQDEKTREYMVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGK NKESIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKK TDIYTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDE EKAKNKVEKLINSITFLIDKKEK*" gene complement(3275274..3275999) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" S_feature complement(3276000..3276088) /Source="Nicolas_S_feature" /locus_tag="new_3582691_3582779_c" /HighExp="T1.30H, T0.30H, T1.0H, T2.0H, T2.30H, T3.0H, T-1.40H, T-1.10H, MG 150, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1330" promotor_-10 complement(3276088..3276107) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3276088) /Source="Nicolas_upshifts" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" S_feature complement(3276090..3276219) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" promotor_-35 complement(3276123..3276126) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3276245..3276874) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" gene complement(3276245..3276874) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" downshifts complement(3276264) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" CDS complement(3276871..3277629) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" gene complement(3276871..3277629) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" CDS complement(3277626..3278363) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" gene complement(3277626..3278363) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" CDS complement(3278360..3278998) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" gene complement(3278360..3278998) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" promotor_no_box 3278856..3278956 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3278916 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3278999..3279583) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" gene complement(3278999..3279583) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" CDS complement(3279580..3280863) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" gene complement(3279580..3280863) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" CDS complement(3280860..3281501) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" gene complement(3280860..3281501) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" CDS complement(3281494..3282669) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " gene complement(3281494..3282669) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" S_feature complement(3282670..3282747) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 3282713..3282719 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3282731..3282750 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3282731..3282750) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3282744 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(3282747) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" promotor_-35 complement(3282763..3282770) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3282879..3282898 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3282886 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" CDS 3282920..3283672 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" gene 3282920..3283672 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" S_feature 3283673..3283911 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(3283694..3283705) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3283700) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3283720..3283726) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3283912..3284577 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" gene 3283912..3284577 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" downshifts 3284548 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" CDS complement(3284597..3285115) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" gene complement(3284597..3285115) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" downshifts complement(3284631) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" CDS complement(3285119..3285769) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" gene complement(3285119..3285769) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" CDS complement(3285766..3286704) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" gene complement(3285766..3286704) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" CDS complement(3286728..3287537) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" gene complement(3286728..3287537) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" CDS complement(3287551..3288483) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" gene complement(3287551..3288483) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" promotor_-10 complement(3288525..3288544) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3288531) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" promotor_-35 complement(3288560..3288565) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3288600..3288607 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3288619 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" promotor_-10 3288622..3288639 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3288665..3289855 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" gene 3288665..3289855 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" promotor_-35 3289653..3289659 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3289674 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" promotor_-10 3289675..3289693 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3289852..3290580 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" gene 3289852..3290580 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" CDS 3290598..3291329 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" gene 3290598..3291329 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" CDS complement(3291349..3295218) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" gene complement(3291349..3295218) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" downshifts complement(3291471) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" promotor_-10 complement(3295238..3295249) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3295245) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" promotor_-35 complement(3295264..3295270) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3295308..3295314 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3295328..3295347 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3295333 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" CDS 3295383..3295856 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" gene 3295383..3295856 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" S_feature 3295857..3295964 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(3295897..3297114) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" gene complement(3295897..3297114) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" downshifts complement(3295910) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" promotor_-35 3295936..3295941 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3295956..3295967 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3295966..3296251 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 3295966 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" downshifts 3296208 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" CDS complement(3297130..3297876) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" gene complement(3297130..3297876) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" S_feature complement(3297877..3298063) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(3298049..3298068) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3298063) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" promotor_-35 complement(3298082..3298089) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3298197..3298204 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3298219..3298238 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3298231 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" S_feature 3298232..3298301 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 3298302..3298811 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" gene 3298302..3298811 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" S_feature complement(3298707..3300045) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(3298748) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" CDS 3298832..3300043 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" gene 3298832..3300043 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" downshifts 3300041 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" CDS complement(3300071..3300430) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" gene complement(3300071..3300430) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" S_feature 3300086..3300802 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(3300090) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" CDS complement(3300432..3300629) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" gene complement(3300432..3300629) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" CDS complement(3300634..3301731) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" gene complement(3300634..3301731) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" CDS complement(3301756..3302082) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" gene complement(3301756..3302082) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" promotor_-10 complement(3302135..3302150) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3302150) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" S_feature complement(3302152..3302642) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(3302162..3302171) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3302230..3302233 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3302248..3302267 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3302258 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" CDS 3302300..3302530 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" gene 3302300..3302530 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" promotor_-10 complement(3302633..3302652) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(3302643) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" promotor_-35 complement(3302668..3302672) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(3302729..3303211) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" gene complement(3302729..3303211) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo downshifts 3302737 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" downshifts complement(3302752) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" upshifts complement(3302884) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(3302892..3302895) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3302972..3302976) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3302972) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3302992..3302995) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3303212..3303345) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(3303373..3306246) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" gene complement(3303373..3306246) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" downshifts complement(3303390) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" CDS complement(3306254..3308239) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" gene complement(3306254..3308239) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" promotor_-10 complement(3308273..3308292) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3308285) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" S_feature complement(3308287..3308372) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(3308304..3308311) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3308417) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" CDS complement(3308425..3308655) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" gene complement(3308425..3308655) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" promotor_-10 complement(3308682..3308701) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(3308692) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" S_feature complement(3308694..3308758) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(3308715..3308722) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(3308735..3308753) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3308756) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" promotor_-35 complement(3308768..3308774) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3308824) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" promotor_no_box complement(3308850..3308950) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3308890) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3308972..3308979 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3308993..3309012 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3309010 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3309102..3311597 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" gene 3309102..3311597 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" misc_feature 3311612..3311616 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3311630 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" CDS 3311673..3312242 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" gene 3311673..3312242 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" CDS 3312273..3313607 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" gene 3312273..3313607 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" downshifts 3313588 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" CDS complement(3313655..3314848) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" gene complement(3313655..3314848) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" downshifts complement(3313664) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" downshifts complement(3313729) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" S_feature complement(3314849..3314926) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(3314852) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" CDS complement(3314927..3315265) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" gene complement(3314927..3315265) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo CDS complement(3315240..3315356) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" gene complement(3315240..3315356) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo S_feature complement(3315357..3315446) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(3315428..3315446) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3315446) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" S_feature complement(3315448..3315528) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(3315460..3315465) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3315514..3315532) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3315528) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" promotor_-35 complement(3315546..3315553) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3315665..3317107) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" gene complement(3315665..3317107) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" downshifts complement(3315754) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" promotor_-10 complement(3317153..3317164) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3317164) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" promotor_-35 complement(3317179..3317185) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3317247..3318137) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" gene complement(3317247..3318137) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" downshifts complement(3317264) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" CDS complement(3318130..3318816) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" gene complement(3318130..3318816) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" S_feature complement(3318817..3318949) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(3318939..3318958) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3318949) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" promotor_-35 complement(3318973..3318976) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3319050..3319388) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" gene complement(3319050..3319388) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" downshifts complement(3319051) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" promotor_-10 complement(3319415..3319434) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3319428) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" CDS complement(3319437..3320321) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" gene complement(3319437..3320321) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" promotor_-35 complement(3319448..3319455) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(3320309..3320328) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3320330) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" promotor_-35 complement(3320343..3320350) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(3321478..3321549), complement(3320448..3321476)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" gene complement(3320448..3321549) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" downshifts complement(3320464) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" S_feature complement(3321550..3321618) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(3321619..3324144) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" gene complement(3321619..3324144) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" S_feature complement(3324145..3324225) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(3324215..3324234) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3324225) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" CDS complement(3324312..3324881) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" gene complement(3324312..3324881) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" downshifts complement(3324320) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" promotor_-35 3324848..3324854 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3324867..3324886 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3324874 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3324908..3324926) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3324916) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" S_feature complement(3324918..3325038) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(3324938..3324946) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3325022..3325040) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3325038) /Source="Nicolas_upshifts" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" promotor_-35 complement(3325056..3325061) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3325072..3325449) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097791.1" /db_xref="EnsemblGenomes-Gn:BSU35319" /db_xref="EnsemblGenomes-Tr:CAX52698" /db_xref="UniProtKB/Swiss-Prot:C0H3R9" /translation="MKSIEDYTLLSAYYHLLFTIEEGLCYLIEAEENLSKTEGDRIYQ DLIQAFFYLDSTHSTLLFIMDSRCAEICVKAFDQIFAEFDQLVSFSFPSHEFCEYLKE HFLIHYRKWMLSIHQCMEPFLIN*" gene complement(3325072..3325449) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" CDS complement(3325459..3325800) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16952964; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliT involved in control of flagella expression" /protein_id="NP_391412.1" /db_xref="EnsemblGenomes-Gn:BSU35320" /db_xref="EnsemblGenomes-Tr:CAB15549" /db_xref="GOA:P39740" /db_xref="SubtiList:BG10923" /db_xref="UniProtKB/Swiss-Prot:P39740" /translation="MNNIDQLYTETKSMLSHIQNTPESDELLKQIEDFVATRSELIQE ISLPLSEEERKQMKLILTWDQLIVKEMERLKQSIATELQQMKRKRVMHTTYLNPYNNI TIDGTYYDKRK*" gene complement(3325459..3325800) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" CDS complement(3325797..3326198) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16806204, 16936039, 20534509, 23144244, 23874669; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliS" /protein_id="NP_391413.1" /db_xref="EnsemblGenomes-Gn:BSU35330" /db_xref="EnsemblGenomes-Tr:CAB15550" /db_xref="GOA:P39739" /db_xref="InterPro:IPR003713" /db_xref="InterPro:IPR036584" /db_xref="PDB:1VH6" /db_xref="SubtiList:BG10922" /db_xref="UniProtKB/Swiss-Prot:P39739" /translation="MAIQNPYTAYQQNSVNTATPGELTLMLYNGCLKFIRLAAQAIEN DDMERKNENLIKAQNIIQELNFTLNRNIELSASMGAMYDYMYRRLVQANIKNDTGMLA EVEGYVTDFRDAWKQAIQSERKDRHGSGGIA*" gene complement(3325797..3326198) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" CDS complement(3326220..3327716) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9648743, 12354229, 24296669, 25355936; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-associated capping protein 2 (HAP2)" /protein_id="NP_391414.1" /db_xref="EnsemblGenomes-Gn:BSU35340" /db_xref="EnsemblGenomes-Tr:CAB15551" /db_xref="GOA:P39738" /db_xref="InterPro:IPR003481" /db_xref="InterPro:IPR010809" /db_xref="InterPro:IPR010810" /db_xref="SubtiList:BG10921" /db_xref="UniProtKB/Swiss-Prot:P39738" /translation="MVTRITGLASGMDIDDIVSKLMQTERAPLDKLTQKKQTLEWQRD SYREVNSKIKELQDYMSKNTLTYPSTYQSKTVTSSNESVLTATGSVSAPNSSSTVEVA SLATAATYKANNYTGYTQGDYNLAFNVVAPGETTAKTVNISVTSADTIDNVISKLNSS DLGVSAFKDKIWNGTEYVETIAFSSKATGAGGSIQAADSATADFMSGQLGFSLDADNK LTAYKEGTNAKVTINGFEMEKLTNNFTVNGVTYSIKNTTAATGPVTTSVSTDVDGIYN QIKEFVDKYNELVDSLNEKLKEEKYRDYTPLTSEQKEAMSDKEVELWEEKAKSGLLRN DSSISTGTNQMRTDFYTQVNADGKTYQLTEFGITTSSAYQLRGHLEINEEKLKAKIAE DPQGVANLFTSGTNDSNYSDKGIMKRITNTLRSTVKSIEAKAGNSTMGASSYSIGKNL NSISTEITDMQDRLNTIENRYYSKFSAMDSAIQKMNEQASYLSQLLVQ*" gene complement(3326220..3327716) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" CDS complement(3327734..3328063) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 19455708; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative flagellar protein of unknown function" /protein_id="NP_391415.1" /db_xref="EnsemblGenomes-Gn:BSU35350" /db_xref="EnsemblGenomes-Tr:CAB15552" /db_xref="InterPro:IPR005186" /db_xref="InterPro:IPR035924" /db_xref="PDB:2HC5" /db_xref="SubtiList:BG10920" /db_xref="UniProtKB/Swiss-Prot:P39737" /translation="MNIERLTTLQPVWDRYDTQIHNQKDNDNEVPVHQVSYTNLAEMV GEMNKLLEPSQVHLKFELHDKLNEYYVKVIEDSTNEVIREIPPKRWLDFYAAMTEFLG LFVDEKK*" gene complement(3327734..3328063) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" downshifts 3328060 /Source="Nicolas_upshifts" /id="D1831" /incds=0 /nref=33 /ntot=140 /MaxReadThrough="2.74277" /MaxDrop="4.24086" /score="8.30527041" /energy="-10.1" /TU="NA" /idTUdmin="U2774" /TUdmin="-3062" /isTUend="FALSE" promotor_-10 complement(3328085..3328103) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3328100) /Source="Nicolas_upshifts" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" S_feature complement(3328102..3328206) /Source="Nicolas_S_feature" /locus_tag="new_3634793_3634897_c" /HighExp="Lbstat, Cold, Gly, S0, Glu, Pyr, M/G, M0t90, C30, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1351" promotor_-35 complement(3328117..3328124) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3328195..3328214) /Source="Nicolas_upshift_promotors" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3328206) /Source="Nicolas_upshifts" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" CDS complement(3328296..3329210) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellin protein" /protein_id="NP_391416.1" /db_xref="EnsemblGenomes-Gn:BSU35360" /db_xref="EnsemblGenomes-Tr:CAB15553" /db_xref="GOA:P02968" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR001492" /db_xref="SubtiList:BG10655" /db_xref="UniProtKB/Swiss-Prot:P02968" /translation="MRINHNIAALNTLNRLSSNNSASQKNMEKLSSGLRINRAGDDAA GLAISEKMRGQIRGLEMASKNSQDGISLIQTAEGALTETHAILQRVRELVVQAGNTGT QDKATDLQSIQDEISALTDEIDGISNRTEFNGKKLLDGTYKVDTATPANQKNLVFQIG ANATQQISVNIEDMGADALGIKEADGSIAALHSVNDLDVTKFADNAADTADIGFDAQL KVVDEAINQVSSQRAKLGAVQNRLEHTINNLSASGENLTAAESRIRDVDMAKEMSEFT KNNILSQASQAMLAQANQQPQNVLQLLR*" gene complement(3328296..3329210) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" downshifts complement(3328316) /Source="Nicolas_upshifts" /id="D1832" /incds=0 /nref=165 /ntot=233 /MaxReadThrough="5.58531" /MaxDrop="7.10921" /score="11.6997504" /energy="-13.1" /TU="U2773" /idTUdmin="U2775" /TUdmin=1078 /isTUend="FALSE" S_feature complement(3329211..3329319) /Source="Nicolas_S_feature" /locus_tag="new_3635902_3636010_c" /HighExp="T2.0H, Glucon, M0t90, T2.30H, GM 15, T-0.40H, GM 10, T1.0H, T-1.10H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1352" promotor_-35 3329277..3329278 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3329287..3329301 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3329296 /Source="Nicolas_upshifts" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3329298..3329316) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-10" upshifts complement(3329319) /Source="Nicolas_upshifts" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" promotor_-35 complement(3329329..3329336) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-35" CDS complement(3329355..3329579) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8982093, 17555441, 21895793, 23144244, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8982093, 17555441, 21895793, 23144244, 27516547; Product type r: regulator" /codon_start=1 /transl_table=11 /product="carbon storage regulator" /protein_id="NP_391417.1" /db_xref="EnsemblGenomes-Gn:BSU35370" /db_xref="EnsemblGenomes-Tr:CAB15554" /db_xref="GOA:P33911" /db_xref="InterPro:IPR003751" /db_xref="InterPro:IPR036107" /db_xref="PDB:1T3O" /db_xref="SubtiList:BG10654" /db_xref="UniProtKB/Swiss-Prot:P33911" /translation="MLVLSRKINEAIQIGADIEVKVIAVEGDQVKLGIDAPKHIDIHR KEIYLTIQEENNRAAALSSDVISALSSQKK*" gene complement(3329355..3329579) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" downshifts complement(3329394) /Source="Nicolas_upshifts" /id="D1833" /incds=0 /nref=22 /ntot=171 /MaxReadThrough="2.28652" /MaxDrop="3.46262" /score="31.5820557" /energy="-9.2" /TU="NA" /idTUdmin="U2775" /TUdmin=0 /isTUend="TRUE" CDS complement(3329573..3330004) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15033535, 16936039, 21895793, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15033535, 16936039, 21895793, 27516547; Product type f: factor" /codon_start=1 /transl_table=11 /product="assembly factor of the flagellum" /protein_id="NP_391418.1" /db_xref="EnsemblGenomes-Gn:BSU35380" /db_xref="EnsemblGenomes-Tr:CAB15555" /db_xref="GOA:P96503" /db_xref="InterPro:IPR003775" /db_xref="InterPro:IPR024046" /db_xref="SubtiList:BG12451" /db_xref="UniProtKB/Swiss-Prot:P96503" /translation="MIIHTKYHGQMNIKEEQIILFESGIPGFLEEKQFVILPLSEDSP FVALQSVTSENLAFIVVSPFIFFKNYEFDLDESTAELLDIDNIQDVEVMTILTMAEPF EKSTANLLAPIIVNRKNMMAKQVVLHDSSYTTKHPIGGESC*" gene complement(3329573..3330004) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" CDS complement(3330025..3330600) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391419.1" /db_xref="EnsemblGenomes-Gn:BSU35390" /db_xref="EnsemblGenomes-Tr:CAB15556" /db_xref="SubtiList:BG12450" /db_xref="UniProtKB/Swiss-Prot:P96502" /translation="MQIPRLIMHSVQGKIGLTTTPASLKMEQPQADLEIEQPSAEMEI SVTPGKLTIDQTQAWEELDRKHVFKRIEEAAQQGHEDVMEGIARTAEEGDELMKIENK GNPIASQARRNSEMHQIQLGENYAPSLSRVKIQYTPSQLDVQITPRKPVIQAEPHKPI VEYTPGNVKVDMLQYPDLNIDVEYPKESPEK*" gene complement(3330025..3330600) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" CDS complement(3330647..3331543) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction protein" /protein_id="NP_391420.1" /db_xref="EnsemblGenomes-Gn:BSU35400" /db_xref="EnsemblGenomes-Tr:CAB15557" /db_xref="GOA:P96501" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR013384" /db_xref="SubtiList:BG11936" /db_xref="UniProtKB/Swiss-Prot:P96501" /translation="MRVTQGMIQQNSLRYIGSSYSKLDKLQSQISSGKKISKASDDPV VAMKSLKYNTQLSQVQQYKSNASQAFTWLENTETNITEGIDILSKVRELAVEAQNDTN GEPERQAIGVEVKQLKEQLLNIANTQVNGRYIFNGTNSDKPPVTDNGDGTYTISDTAD VVVNISNNMSLKVNSDPKSAFGGTSESGQNVFEMLDSFEKALNSGSLDGMDSVLNDID HFSDGMSAERSDLGARYNRLELVNTRLSAQEETATKVLSDNEDVELEEVITEFIAQQS VHRATLAVNAQIVQPTLIDFLK*" gene complement(3330647..3331543) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" downshifts complement(3330670) /Source="Nicolas_upshifts" /id="D1834" /incds=0 /nref=112 /ntot=251 /MaxReadThrough="5.50861" /MaxDrop="3.8234" /score="0.376587888" /energy="-4.8" /TU="U2775,U2776,U2777" /idTUdmin="U2777" /TUdmin="-1254" /isTUend="FALSE" misc_feature 3330959..3330962 /Source="Nicolas_upshift_promotors" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3330968 /Source="Nicolas_upshifts" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3331554..3333077) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction" /protein_id="NP_391421.1" /db_xref="EnsemblGenomes-Gn:BSU35410" /db_xref="EnsemblGenomes-Tr:CAB15558" /db_xref="GOA:P39810" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR002371" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10401" /db_xref="UniProtKB/Swiss-Prot:P39810" /translation="MTSTFMGLETARRALSAQQAALSTTANNVANANTDGYTRQRVSL EATDYFPAVSKNAEKTAGQMGTGVQGKSVERIRDIFLDYQYRLQNNSAGYYDTKAKAL SQMEGVLNETDDSGLNSVLNSFWNSLQELSNNTNEESARSVVARKGQAVAETFNYISE SLTNVQSNLKAELNTTVLDVNSLLSQLNSLNKQIAQVEPVGLLPNGLYDQRDLLIDKL SSMVDIKVSYNKSGGNALASAEGTVSIEILDKNKQSLGTVLDGKNYEVSELAANYDNE TGLVSSISIGDTAVQAESFSSKGSLLGFIESYGYITADGQEKGVYPEMLSDLDNMALE FAKAFNEVHRNGVTKSGEQGGDFFDFTGGETEPAKGAAGKIKVADSIIDSKGANIAFS LTGAANDNANATKLANVLTGKITINGKETSVLDYYAGLIGELGIEAQEANRLASNTET QLNDADINRQQMSAVSLDEEMTNMIQFQHAYNAAARMVTLQDELLDKVINGMGVGGR* " gene complement(3331554..3333077) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" CDS complement(3333096..3333578) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" gene complement(3333096..3333578) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" CDS complement(3333594..3333860) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" gene complement(3333594..3333860) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" S_feature complement(3333861..3333940) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(3333941..3334360) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" gene complement(3333941..3334360) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" promotor_-10 complement(3334399..3334417) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3334410) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" promotor_-35 complement(3334431..3334438) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3334434..3335156) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" gene complement(3334434..3335156) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" CDS complement(3335120..3335416) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" gene complement(3335120..3335416) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" promotor_-10 complement(3335442..3335461) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3335455) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" promotor_-35 complement(3335472..3335479) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3335476..3336867) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" gene complement(3335476..3336867) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" promotor_-10 complement(3336881..3336900) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3336896) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" promotor_-35 complement(3336914..3336921) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3336973..3337818) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" gene complement(3336973..3337818) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" downshifts complement(3336984) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" promotor_-35 3337235..3337242 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3337256..3337275 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3337266..3338998 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 3337266 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" promotor_-10 complement(3337845..3337864) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3337864) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" promotor_-35 complement(3337879..3337882) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3337916..3338605) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" gene complement(3337916..3338605) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" downshifts complement(3337930) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" S_feature complement(3338606..3338687) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(3338688..3339845) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" gene complement(3338688..3339845) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" S_feature complement(3339846..3339973) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 3339893..3339896 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3339911..3339930 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3339922..3340008 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 3339922 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" promotor_-10 complement(3339967..3339986) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3339973) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" promotor_-35 3339990..3339998 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3339997..3340004) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3340010 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" promotor_-10 3340012..3340020 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3340062..3340715 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " gene 3340062..3340715 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" S_feature complement(3340418..3341010) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 3340715..3341890 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " gene 3340715..3341890 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" promotor_-10 complement(3341006..3341024) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3341015) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" promotor_-35 complement(3341038..3341044) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3341862 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" CDS complement(3341963..3343039) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" gene complement(3341963..3343039) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" downshifts complement(3341979) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" promotor_-35 3342025..3342034 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3342048..3342067 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3342056..3343289 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 3342056 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" S_feature complement(3343040..3343122) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(3343110..3343129) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3343122) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" promotor_-35 complement(3343141..3343147) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3343184..3344377) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" gene complement(3343184..3344377) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" downshifts complement(3343214) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" CDS complement(3344406..3345164) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" gene complement(3344406..3345164) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" CDS complement(3345188..3345868) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" gene complement(3345188..3345868) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" CDS complement(3345897..3347363) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" gene complement(3345897..3347363) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" S_feature complement(3347364..3347447) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(3347448..3348833) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" gene complement(3347448..3348833) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" CDS complement(3348895..3350064) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" gene complement(3348895..3350064) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" CDS complement(3350061..3351512) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" gene complement(3350061..3351512) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" CDS complement(3351568..3351717) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" gene complement(3351568..3351717) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo CDS complement(3351662..3352201) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" gene complement(3351662..3352201) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo misc_feature complement(3352257..3352274) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3352261) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" CDS complement(3352428..3353918) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" gene complement(3352428..3353918) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" downshifts complement(3352450) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" CDS complement(3353957..3356074) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" gene complement(3353957..3356074) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" CDS complement(3356098..3356406) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" gene complement(3356098..3356406) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" downshifts 3356312 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" promotor_-35 3356402..3356406 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3356415..3356429 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3356416..3356434) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3356422 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3356448..3356455) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3356451) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" promotor_-35 3356472..3356480 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3356494..3356507 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3356512 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" CDS 3356590..3357510 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" gene 3356590..3357510 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" downshifts 3357500 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" CDS complement(3357550..3358692) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" gene complement(3357550..3358692) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" downshifts complement(3357574) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" promotor_-10 complement(3358731..3358750) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3358745) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" promotor_-35 complement(3358765..3358768) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3358821..3358825 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3358841..3358860 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3358842..3358937 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 3358843 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" CDS 3358938..3359816 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" gene 3358938..3359816 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" S_feature 3359817..3360908 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(3359886..3360241) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 3360150..3360368 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" gene 3360150..3360368 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" CDS complement(3360242..3360325) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" gene complement(3360242..3360325) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo S_feature complement(3360326..3360517) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(3360518..3363220) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" gene complement(3360518..3363220) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" S_feature complement(3363221..3363343) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 3363242..3363248 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3363263..3363281 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3363268..3366100 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 3363268 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" CDS complement(3363344..3364684) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" gene complement(3363344..3364684) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo CDS complement(3364725..3364931) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" gene complement(3364725..3364931) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo S_feature complement(3364932..3365805) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(3365799..3365818) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3365805) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" S_feature complement(3365807..3366046) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(3365831..3365837) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3366028..3366046) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(3366046) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" promotor_-35 complement(3366060..3366067) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 3366069..3366076 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3366088..3366107 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3366102..3366232 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 3366102 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" promotor_no_box 3366174..3366274 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3366234 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" CDS 3366238..3366834 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" gene 3366238..3366834 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo downshifts 3366432 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" CDS complement(3366873..3368456) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" gene complement(3366873..3368456) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" downshifts 3366916 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" CDS complement(3368476..3369303) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " gene complement(3368476..3369303) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" S_feature complement(3369304..3369368) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(3369364..3369383) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3369368) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" S_feature complement(3369370..3369467) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(3369399..3369402) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3369468..3371708) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" gene complement(3369468..3371708) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" CDS complement(3371708..3373729) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" gene complement(3371708..3373729) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" promotor_-35 3372471..3372480 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3372493..3372508 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3372504 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3373730..3373889) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(3373890..3374279) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" gene complement(3373890..3374279) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" S_feature complement(3374280..3374414) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(3374398..3374417) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3374414) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" promotor_-35 complement(3374428..3374435) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3374569..3374575 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3374586..3374678 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 3374586 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" promotor_-10 3374587..3374606 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3374679..3375449 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" gene 3374679..3375449 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" S_feature complement(3374806..3375154) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(3375158..3375169) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3375162) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" promotor_-35 complement(3375184..3375190) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3375474 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" CDS 3375482..3376627 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" gene 3375482..3376627 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" downshifts 3376615 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" promotor_-35 3376669..3376676 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3376691..3376710 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3376701 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" CDS 3376747..3378075 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" gene 3376747..3378075 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" downshifts 3378070 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" downshifts complement(3378131) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" CDS complement(3378135..3380777) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" /EC_number="3.2.1.96" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9537764, 10206711, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537764, 10206711, 17298895, 19542270, 22469514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported N-acetylglucosaminidase (major autolysin) (CWBP90)" /protein_id="NP_391459.1" /db_xref="EnsemblGenomes-Gn:BSU35780" /db_xref="EnsemblGenomes-Tr:CAB15595" /db_xref="GOA:P39848" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10455" /db_xref="UniProtKB/Swiss-Prot:P39848" /translation="MKKRLIAPMLLSAASLAFFAMSGSAQAAAYTDYSLYKVEPSNTF STESQASQAVAKLEKDTGWDASYQASGTTTTYQISASGIHSESEAKAILSGLAKQTSI TGTSSPVGSKQPYVTISSGAISGEKQANTILAKLKQETGVAGAVKAYGAAQPYMNVMT SDIADETKVKALIQSLAKQTGIKSSYQPITHTVSVTTIQSGTIVGDSRAAQIKNAFQK ESGLQASLKETVKGQAYYTFTTAAISGEANAKTLLQQLKQSTGITGSYKSINQKTTVE SYNVQSAYFKGLSTVKDAISQIKKNTGVSGSYQQVGKSTSYTVNMKGITKQQLQKIDT FFKKKKWHYTSSSVKKTTTSAAYQITTAKILGEQQANKAAAFFAQKKVKAAKTAAGST AENQYQLISEETSDQAKVTKGLNILKKNQLSASAKSVKKQIADTFKITTESLLDQTKV NQALTFFKSNHISVASQKTGQTAASSYQITTEAIISQEEIDRVLTFFKQNHIAVTTSK TGQTAYTQYKIVTTQLSSKTALNNGLTYLKSKSVTPSYTTKSNTLYKISVNEQFTGND TAAAASTKLKQLYGWTSSIVKIKNGPQIMKTNYNLSLRDMVQKQMTVSPQTDGAAYVS LTYINTATSTVTADVLNIRSTPEVSPTNVIGQFKKGDKVKVIGQINGWAKINLGWRNA SSDEVVQYVDPNNFSRDSKYYFQFLKLSQTAGLSVTEVNQKVLAGKGILTGRAKAFID AANQYSINELYLISHALLETGNGTSALANGLTYNGKTVYNMYGIGAYDSNPNYYGAKY AYEQGWFTPEAAIIGGAKFIGSSYIHNTAYNQDTLYKMRWSATATHQYATDIGWAYKQ VNRMYSLYSLLDGYTLYFDVPEYR*" gene complement(3378135..3380777) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" promotor_-10 complement(3379380..3379399) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3379382) /Source="Nicolas_upshifts" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3379412..3379421) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3380812..3380830) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3380817) /Source="Nicolas_upshifts" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" promotor_-35 complement(3380844..3380851) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3380906..3381856) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7581999, 10704478, 19447949, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7581999, 10704478, 19447949, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannose-6-phosphate isomerase (active on aldose substrates with hydroxyl groups oriented in the same direction at the C-2 and C-3 positions as in mannose)" /protein_id="NP_391460.1" /db_xref="EnsemblGenomes-Gn:BSU35790" /db_xref="EnsemblGenomes-Tr:CAB15596" /db_xref="GOA:P39841" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="PDB:1QWR" /db_xref="SubtiList:BG10454" /db_xref="UniProtKB/Swiss-Prot:P39841" /translation="MTQSPIFLTPVFKEKIWGGTALRDRFGYSIPSESTGECWAISAH PKGPSTVANGPYKGKTLIELWEEHREVFGGVEGDRFPLLTKLLDVKEDTSIKVHPDDY YAGENEEGELGKTECWYIIDCKENAEIIYGHTARSKTELVTMINSGDWEGLLRRIKIK PGDFYYVPSGTLHALCKGALVLETQQNSDATYRVYDYDRLDSNGSPRELHFAKAVNAA TVPHVDGYIDESTESRKGITIKTFVQGEYFSVYKWDINGEAEMAQDESFLICSVIEGS GLLKYEDKTCPLKKGDHFILPAQMPDFTIKGTCTLIVSHI*" gene complement(3380906..3381856) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" downshifts complement(3380918) /Source="Nicolas_upshifts" /id="D1850" /incds=0 /nref=29 /ntot=177 /MaxReadThrough="4.74566" /MaxDrop="3.72936" /score="9.64549533" /energy="-7.7" /TU="U2805" /idTUdmin="U2806" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3381881..3381899) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3381886) /Source="Nicolas_upshifts" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" S_feature complement(3381888..3382024) /Source="Nicolas_S_feature" /locus_tag="new_3688579_3688715_c" /HighExp="Lbtran, S0, M40t90, T1.0H, dia0, Mt0, Lbstat, M0t90, Lbexp, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17043900000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1377" promotor_-35 complement(3381914..3381920) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3381998..3382017) /Source="Nicolas_upshift_promotors" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3382026) /Source="Nicolas_upshifts" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" promotor_-35 3382054..3382060 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3382074..3382085 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3382074 /Source="Nicolas_upshifts" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" CDS 3382121..3383572 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391461.2" /db_xref="EnsemblGenomes-Gn:BSU35800" /db_xref="EnsemblGenomes-Tr:CAB15597" /db_xref="GOA:P39569" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10640" /db_xref="UniProtKB/Swiss-Prot:P39569" /translation="MQIDSDLQNNLDTLKKTLGQNDDMMFYTFAFGDSRQKACLLYID GLTENKMLAQYVISPLQKEALAHKECSIEDLSAFFFGFHHSVVSTMKEIEQLVFSGQA ILLADGYRGGLAFDTKSVATRSLDEPSSEVVERGPKIGFIEKLRTNTALLRERTSDPN LVIKEMTLGKRTKKKIAVAYIQDIAPDYVVKEVFKRLKSVNIDNLPESGTLEQLIEDE PFSIFPTILSTERPDRVESSLLEGRVSILVDGTPFALIVPATVDEFIHSPDDYSQRWI PMSLVRLLRYSSILITIYLPGLYISLVSFHTGLLPTRMAISIAGSRLNVPFPPFVEAF IMIFTIELIREAGLRLPKPIGQTIGLIGGVVIGQAAVQAQIVSALMVIVVSVTALASF TVPSYAYNFPLRIIRIGVMISATALGMYGVIMVYLFVIGHLMRLKSFGQDYIIPIMAQ PGQDLKDTVIRIPTMFLKRRPTRNDPEDNIRQR*" gene 3382121..3383572 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" CDS 3383578..3384684 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 22493018; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391462.2" /db_xref="EnsemblGenomes-Gn:BSU35810" /db_xref="EnsemblGenomes-Tr:CAB15598" /db_xref="GOA:P39570" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10641" /db_xref="UniProtKB/Swiss-Prot:P39570" /translation="MRKSEHKLTFMQTLIMISSTLIGAGVLTLPRSAAETGSPSGWLM ILLQGVIFIIIVLLFLPFLQKNSGKTLFKLNSIVAGKFIGFLLNLYICLYFIGIVCFQ ARILGEVVGFFLLKNTPMAVVVFIFLAVAIYHVGGGVYSIAKVYAYIFPITLIIFMML LMFSFRLFQLDFIRPVFEGGYQSFFSLFPKTLLYFSGFEIIFYLVPFMRDPKQVKKAV ALGIATSTLFYSITLLIVIGCMTVAEAKTVTWPTISLIHALEVPGIFIERFDLFLQLT WTAQQFACMLGSFKGAHIGLTEIFHLKNKNNAWLLTAMLAATFFITMYPKDLNDVFYY GTLLGYAFLIVITIPFFVWFLSWIQKKIGRGQLQ*" gene 3383578..3384684 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" CDS 3384681..3385805 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein component of the germination receptor B" /protein_id="NP_391463.1" /db_xref="EnsemblGenomes-Gn:BSU35820" /db_xref="EnsemblGenomes-Tr:CAB15599" /db_xref="GOA:P39571" /db_xref="InterPro:IPR008844" /db_xref="PDB:3N54" /db_xref="SubtiList:BG10642" /db_xref="UniProtKB/Swiss-Prot:P39571" /translation="MKTASKFSVMFFMLLALCGCWDVKDIEQLSFARGLAIDETNDHQ YKLTYQNLLPQSEDSQASGKPEFVNVTSHGKTILEAVSDVSIKDPPVYSDHLKVILLG EKLMRNQNVDQVLNHFIRDDELRRSSYLMAARGNAADVFTKGNPNQQQPMPSEKLIDL TTHSGYNGKIMIPLRIGRASVYSQNGYSYLIQAVKNEKGKAKYDGAGIIKRGSNKLVG FLSADETQTLSWVMGTIQGGVMPTTDKGHPITFEIKKSKTKIKPVIENGKPVFHISVK TKGILTEDQNPNENSFSKSYLHRLENIFEKKLERDVKQVMDKLQHEYKTDPVFLSDHI RIQHPDYWNKVKGHWDEIFSETDFKYDISFKIINFGTVGK*" gene 3384681..3385805 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" S_feature complement(3384908..3385802) /Source="Nicolas_S_feature" /locus_tag="new_3691599_3692493_c" /HighExp="Etha, Sw, Salt, Heat, S8, B36, Gly, S7, LPhT, S6" /AntisenseName="gerBC" /AntisenseCor="0.12062795031199899" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1378" downshifts 3385795 /Source="Nicolas_upshifts" /id="D1851" /incds=0 /nref=18 /ntot=72 /MaxReadThrough="0.37711" /MaxDrop="4.85405" /score="35.6875936" /energy="-14.9" /TU="NA" /idTUdmin="U2807" /TUdmin=0 /isTUend="TRUE" CDS complement(3385842..3387215) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate/proton transporter" /protein_id="NP_391464.2" /db_xref="EnsemblGenomes-Gn:BSU35830" /db_xref="EnsemblGenomes-Tr:CAB15600" /db_xref="GOA:C0SPB2" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12538" /db_xref="UniProtKB/Swiss-Prot:C0SPB2" /translation="MKKQSNIWLYFFGALGGALYGYDTGVISGAILFMKKELGLNAFT EGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLF RIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEA WRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGTKDIDQEIHDI KEAEKQDEGGLKELFDPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSA SILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNLFFDNTPA ASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLT YPILMEAIGISYLFLIYAAIGIMAFLFVRFKVTETKGRSLEEIEQDLRDKNGQGGAAG KQQTVGT*" gene complement(3385842..3387215) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" downshifts complement(3385847) /Source="Nicolas_upshifts" /id="D1852" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="6.08746" /MaxDrop="3.99424" /score="22.7548183" /energy="-16.7" /TU="U2808" /idTUdmin="U2808" /TUdmin="-900" /isTUend="FALSE" S_feature complement(3387216..3387279) /Source="Nicolas_S_feature" /locus_tag="new_3693907_3693970_c" /HighExp="Etha, Salt, Gly, Heat, Sw, LPhT, HiTm, Diami, B60, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1379" promotor_-10 complement(3387267..3387285) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3387280) /Source="Nicolas_upshifts" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" promotor_-35 complement(3387300..3387306) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3387366..3387375 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3387387..3387402 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3387389..3387509 /Source="Nicolas_S_feature" /locus_tag="new_3694080_3694200" /HighExp="T-0.40H, LBGstat, T-1.10H, T0.30H, Heat, T-1.40H, T1.30H, T1.0H, T0.0H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1380" upshifts 3387389 /Source="Nicolas_upshifts" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" promotor_-35 3387484..3387491 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3387505..3387524 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3387511 /Source="Nicolas_upshifts" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" CDS 3387548..3388516 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" /function="12: Regulatory functions" /experiment="publication(s) with functional evidences, PMID:19099556, 22432711, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 22432711, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of capsule synthesis" /protein_id="NP_391465.2" /db_xref="EnsemblGenomes-Gn:BSU35840" /db_xref="EnsemblGenomes-Tr:CAB15601" /db_xref="GOA:Q7WY78" /db_xref="InterPro:IPR004474" /db_xref="PDB:3MEJ" /db_xref="PDB:4DE9" /db_xref="SubtiList:BG12537" /db_xref="UniProtKB/Swiss-Prot:Q7WY78" /translation="MEERSQRRKKKRKLKKWVKVVAGLMAFLVIAAGSVGAYAFVKLN NASKEAHVSLARGEQSVKRIKEFDPGKDSFSVLLLGIDAREKNGETVDQARSDANVLV TFNRKEKTAKMLSIPRDAYVNIPGHGYDKFTHAHAYGGVDLTVKTVEEMLDIPVDYVV ESNFTAFEDVVNELNGVKVTVKSDKVIQQIKKDTKGKVVLQKGTHTLDGEEALAYVRT RKADSDLLRGQRQMEVLSAIIDKSKSLSSIPAYDDIVDTMGQNLKMNLSLKDAIGLFP FITSLKSVESIQLTGYDYEPAGVYYFKLNQQKLQEVKKELQNDLGV*" gene 3387548..3388516 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" downshifts 3388501 /Source="Nicolas_upshifts" /id="D1853" /incds=0 /nref=27 /ntot=139 /MaxReadThrough="6.07699" /MaxDrop="4.78541" /score="17.3040761" /energy="-17.8" /TU="U2809,U2810" /idTUdmin="U2809" /TUdmin="-1012" /isTUend="FALSE" promotor_-35 3388560..3388567 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3388582..3388601 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3388589..3388671 /Source="Nicolas_S_feature" /locus_tag="new_3695280_3695362" /HighExp="Etha, dia5, Lbtran, dia15, LBGexp, LBGtran, G150, Mt0, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.982, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1381" upshifts 3388589 /Source="Nicolas_upshifts" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" CDS 3388672..3389532 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous activity)" /protein_id="NP_391466.1" /db_xref="EnsemblGenomes-Gn:BSU35850" /db_xref="EnsemblGenomes-Tr:CAB15602" /db_xref="GOA:P96741" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12536" /db_xref="UniProtKB/Swiss-Prot:P96741" /translation="MKCIAIDLDGTLLNKESVISAENREAIKRAVDAGILVTICTGRA TFDVKALLDDLDIPIIAANGGTIHDTGYRLISRTLMDQEAGKAIADYLLSKNIYFEVY TDDHLLSPFDGEAKLHAELDILKSANPNEQTDDLWQGAMTQFKQFGIKPIPHIESVFD GGENIYKLLCFSFDMDKLKQAKEELKHHKKLAQTSSGKHIIEILPASSGKGRALTKLA DIYGIETQDIYAIGDSPNDLSMFEVAGHRIAMENAIDELKEKSTFVTKSNDENGVAYF IDQLLSGQYA*" gene 3388672..3389532 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" downshifts 3389513 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" CDS complement(3389566..3390807) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" gene complement(3389566..3390807) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" downshifts complement(3389585) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" promotor_-10 complement(3390829..3390847) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3390851) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" promotor_-35 complement(3390860..3390867) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3390948..3391115) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" gene complement(3390948..3391115) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" downshifts complement(3390975) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" CDS complement(3391130..3392272) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" gene complement(3391130..3392272) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" CDS complement(3392291..3392740) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" gene complement(3392291..3392740) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" promotor_-35 3392434..3392440 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 3392448 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" promotor_-10 3392454..3392472 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 3392461..3394670 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(3392755..3393936) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" gene complement(3392755..3393936) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" promotor_-35 3394650..3394657 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3394672 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" promotor_-10 3394673..3394692 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3394693) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3394698..3394712) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3394720..3394724) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3394720..3395700 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" gene 3394720..3395700 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" promotor_-35 3395549..3395556 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3395570..3395589 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3395585 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" CDS 3395702..3396583 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" gene 3395702..3396583 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" CDS 3396580..3396975 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" gene 3396580..3396975 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" CDS 3396991..3398472 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" gene 3396991..3398472 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" CDS 3398474..3399442 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" gene 3398474..3399442 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" CDS 3399454..3400371 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" gene 3399454..3400371 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" promotor_-35 3400380..3400386 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3400401..3400419 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3400403 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" CDS 3400453..3400989 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" gene 3400453..3400989 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" downshifts 3400972 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" S_feature 3401017..3401127 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 3401096..3401102 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3401117..3401128 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3401129 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" CDS 3401145..3401441 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" gene 3401145..3401441 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" S_feature 3401442..3402094 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(3401481..3402008) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" gene complement(3401481..3402008) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" downshifts complement(3401491) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3402028..3402047) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3402041) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" downshifts 3402052 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" promotor_-35 complement(3402061..3402068) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3402107) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" CDS complement(3402108..3402875) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" gene complement(3402108..3402875) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" CDS complement(3402937..3404649) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" gene complement(3402937..3404649) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" promotor_-35 3403548..3403557 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3403571..3403590 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3403571 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3404703..3404722) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3404708) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" promotor_-35 3404728..3404735 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3404737..3404741) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3404749..3404768 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3404759 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" CDS 3404807..3405715 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" gene 3404807..3405715 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" promotor_-35 3405783..3405791 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3405793..3405925 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3405793 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" promotor_-10 3405805..3405824 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3405926..3407254 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" gene 3405926..3407254 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" downshifts 3407245 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" CDS complement(3407311..3407988) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" gene complement(3407311..3407988) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" downshifts complement(3407321) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" CDS complement(3408048..3409190) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" gene complement(3408048..3409190) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" promotor_-10 complement(3409227..3409246) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3409235) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" S_feature complement(3409237..3409317) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3409260..3409268) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3409318..3410406) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" gene complement(3409318..3410406) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" S_feature complement(3410407..3410520) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3410462..3410471 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3410484..3410503 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3410497 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" upshifts complement(3410520) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" promotor_-10 complement(3410524..3410538) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3410547..3410551) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3410547..3411134 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" gene 3410547..3411134 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" CDS 3410635..3411114 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " gene 3410635..3411114 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" S_feature complement(3411018..3411215) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3411051 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" downshifts complement(3411061) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" downshifts 3411120 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" downshifts 3411199 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" promotor_-10 complement(3411214..3411233) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3411220) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" promotor_-35 3411242..3411249 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3411246..3411255) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3411264..3411283 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3411270 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" CDS 3411308..3411925 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" gene 3411308..3411925 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" S_feature 3411926..3412026 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3411983 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" promotor_-35 3412052..3412061 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3412073..3412088 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3412074 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" CDS 3412103..3412438 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" gene 3412103..3412438 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" promotor_-10 complement(3412394..3412412) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3412403) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3412427..3412432) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3412437 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" CDS complement(3412443..3414020) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" gene complement(3412443..3414020) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" S_feature 3412482..3414193 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3414171..3414178 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3414189..3414208 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3414195 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" CDS 3414234..3414710 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" gene 3414234..3414710 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" CDS 3414724..3415317 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" gene 3414724..3415317 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" CDS 3415314..3415850 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" gene 3415314..3415850 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" downshifts 3415831 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" CDS complement(3415877..3416098) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" gene complement(3415877..3416098) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" upshifts 3416045 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3416052..3416053 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3416095..3416640) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" gene complement(3416095..3416640) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" promotor_-35 3416657..3416664 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3416679..3416698 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3416683 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" CDS 3416763..3417644 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" gene 3416763..3417644 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" CDS complement(3417729..3418445) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" gene complement(3417729..3418445) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" downshifts complement(3417749) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" CDS complement(3418455..3418919) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" gene complement(3418455..3418919) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" CDS complement(3418909..3420717) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" gene complement(3418909..3420717) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" CDS complement(3420736..3420996) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" gene complement(3420736..3420996) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" CDS complement(3421006..3421428) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" gene complement(3421006..3421428) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" S_feature complement(3421429..3421511) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3421503..3421522) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3421511) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" promotor_-35 complement(3421535..3421542) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3421645..3421770) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" gene complement(3421645..3421770) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" S_feature complement(3421688..3421819) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3421731) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" CDS complement(3421820..3422605) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" gene complement(3421820..3422605) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" S_feature complement(3422606..3422721) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3422714..3422733) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3422721) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" promotor_-35 complement(3422747..3422754) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3422797..3424119) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" gene complement(3422797..3424119) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" downshifts complement(3422809) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" upshifts complement(3424153) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" S_feature complement(3424155..3424280) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3424155..3424173) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3424189..3424194) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3424260..3424279) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3424280) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" CDS complement(3424314..3425078) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" gene complement(3424314..3425078) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" downshifts complement(3425097) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" CDS complement(3425131..3425844) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" gene complement(3425131..3425844) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" downshifts complement(3425148) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" CDS complement(3425834..3426580) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" gene complement(3425834..3426580) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" promotor_-10 complement(3426612..3426631) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3426624) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" promotor_-35 complement(3426648..3426651) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3426814..3426957) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" gene complement(3426814..3426957) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" downshifts complement(3426835) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" S_feature complement(3426958..3427043) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3427033..3427044) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3427043) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" S_feature complement(3427045..3427275) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3427082..3427086 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3427102..3427121 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3427111 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" CDS 3427161..3428771 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" gene 3427161..3428771 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" promotor_-10 complement(3427263..3427281) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3427275) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" S_feature complement(3427277..3427451) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3427295..3427302) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3427438..3427457) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3427451) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" promotor_-35 complement(3427471..3427479) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3428758..3431526 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" gene 3428758..3431526 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" downshifts complement(3431575) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" CDS complement(3431652..3432509) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" gene complement(3431652..3432509) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" CDS complement(3432515..3433291) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" gene complement(3432515..3433291) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" promotor_-10 complement(3433317..3433336) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3433339) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" S_feature complement(3433341..3433413) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3433351..3433358) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3433415..3433514) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3433458) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" CDS complement(3433515..3433856) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" gene complement(3433515..3433856) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" promotor_-10 complement(3433878..3433897) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3433897) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" promotor_-35 complement(3433911..3433918) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3433933..3434316) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" gene complement(3433933..3434316) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" promotor_-10 complement(3434338..3434357) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3434345..3434364 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3434349 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(3434358) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" promotor_-35 complement(3434372..3434379) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3434439..3434458 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3434442 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" downshifts complement(3434491) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" CDS 3434491..3434901 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" gene 3434491..3434901 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" S_feature 3434902..3434985 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3434943 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" CDS complement(3435041..3435349) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" gene complement(3435041..3435349) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" downshifts complement(3435042) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" CDS 3435693..3436529 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" gene 3435693..3436529 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" promotor_-35 3435909..3435916 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3435931..3435950 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3435934 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3436528 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" CDS complement(3436576..3436968) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" gene complement(3436576..3436968) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" downshifts complement(3436582) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" CDS complement(3437041..3437466) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" gene complement(3437041..3437466) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" promotor_-10 complement(3437527..3437546) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3437543) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" S_feature complement(3437545..3437629) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3437561..3437568) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3437608 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" misc_feature 3437611..3437630 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3437621..3437640) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3437629) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" S_feature complement(3437631..3438715) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3437654..3437659) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3437658..3438722 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" gene 3437658..3438722 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" S_feature 3438723..3439607 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3438745..3439554) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" gene complement(3438745..3439554) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" downshifts complement(3438760) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" CDS complement(3439588..3440400) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" gene complement(3439588..3440400) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" S_feature complement(3440401..3440480) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3440431..3440438 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3440452..3440471 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3440461 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3440474..3440492) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3440480) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" promotor_-35 complement(3440506..3440513) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3440563..3441564) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " gene complement(3440563..3441564) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" downshifts complement(3440569) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" misc_feature complement(3441619..3441638) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3441643) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" S_feature complement(3441645..3441729) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3441730..3442011) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" gene complement(3441730..3442011) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" CDS complement(3442026..3442136) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" gene complement(3442026..3442136) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" promotor_-10 complement(3442167..3442185) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3442189) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" promotor_-35 complement(3442201..3442206) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3442282..3442288 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3442302..3442321 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3442318 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" CDS 3442361..3442774 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" gene 3442361..3442774 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" CDS 3442796..3443986 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" gene 3442796..3443986 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" CDS complement(3444077..3445483) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" gene complement(3444077..3445483) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" downshifts complement(3444374) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" promotor_-10 complement(3445516..3445535) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3445534) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" promotor_-35 complement(3445550..3445553) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3445589..3447061) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" gene complement(3445589..3447061) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" CDS complement(3447242..3448600) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" gene complement(3447242..3448600) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" downshifts complement(3447256) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" CDS complement(3448600..3449169) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" gene complement(3448600..3449169) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" promotor_-10 complement(3449188..3449199) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3449206) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" promotor_-35 complement(3449213..3449219) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3449276..3449443) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" gene complement(3449276..3449443) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo CDS complement(3449353..3449817) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" gene complement(3449353..3449817) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" promotor_-10 complement(3449847..3449866) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3449852) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" promotor_-35 complement(3449880..3449887) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3450018..3450021 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3450036..3450055 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3450040 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" CDS 3450099..3451313 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" gene 3450099..3451313 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" promotor_-10 complement(3450929..3450947) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3450930) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3450961..3450968) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3451179..3451185 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3451199..3451218 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3451201 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" CDS 3451325..3451675 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" gene 3451325..3451675 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" downshifts 3451668 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" promotor_-35 3451727..3451735 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3451749..3451757 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3451756 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" promotor_-35 3451798..3451807 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3451820..3451835 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3451824 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" CDS 3451856..3452437 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" gene 3451856..3452437 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" promotor_-10 complement(3451954..3451973) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3451964) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3451987..3451995) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3452418 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" CDS complement(3452478..3452900) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" gene complement(3452478..3452900) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" downshifts complement(3452497) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" promotor_-10 complement(3452935..3452950) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3452954) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" promotor_-35 complement(3452963..3452972) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3453011..3453862) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" gene complement(3453011..3453862) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" downshifts complement(3453020) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" downshifts complement(3453262) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" promotor_-35 3453499..3453501 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3453518..3453537 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3453519..3453865 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3453519 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" misc_feature 3453857..3453860 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3453867..3454002 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3453867 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" upshifts complement(3453896) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" misc_feature complement(3453902..3453911) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3454003..3454494 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" gene 3454003..3454494 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" promotor_-35 3454232..3454237 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3454253..3454271 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3454264 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" S_feature complement(3454355..3455263) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3454491..3455009 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" gene 3454491..3455009 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" downshifts 3454814 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" downshifts 3455012 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" CDS 3455168..3455299 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " gene 3455168..3455299 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" CDS complement(3455296..3455730) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" gene complement(3455296..3455730) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" downshifts complement(3455308) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3455779..3455798) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3455786) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" S_feature complement(3455788..3456085) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3455813..3455820) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3455859..3455863 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3455880..3455899 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3455892..3455972 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3455893 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" CDS 3455973..3457421 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" gene 3455973..3457421 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" upshifts complement(3456085) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" promotor_-10 complement(3456086..3456104) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3456087..3456430) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3456120..3456126) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3456408..3456426) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3456430) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" promotor_-35 complement(3456442..3456447) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3457410 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" CDS complement(3457442..3458215) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" gene complement(3457442..3458215) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" downshifts complement(3457464) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" promotor_-35 3458290..3458293 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3458309..3458328 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3458313 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" CDS 3458360..3458743 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" gene 3458360..3458743 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" downshifts 3458730 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" CDS complement(3458778..3459419) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" gene complement(3458778..3459419) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" downshifts complement(3458828) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" CDS complement(3459487..3459888) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" gene complement(3459487..3459888) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" promotor_-10 complement(3459937..3459956) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3459947) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" S_feature complement(3459949..3460022) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3459971..3459976) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3460023..3461732) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" gene complement(3460023..3461732) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" CDS complement(3461729..3462103) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" gene complement(3461729..3462103) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" CDS complement(3462100..3462417) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" gene complement(3462100..3462417) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" S_feature complement(3462418..3462502) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3462502) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" misc_feature complement(3462504..3462517) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3462504..3462597) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3462598..3462762) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" gene complement(3462598..3462762) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" promotor_-10 complement(3462685..3462703) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3462697) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" promotor_-35 complement(3462715..3462723) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3462763..3462934) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3462935..3463117) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" gene complement(3462935..3463117) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo S_feature complement(3463118..3463264) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3463252..3463271) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3463264) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" S_feature complement(3463266..3463379) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3463286..3463293) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" upshifts 3463393 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3463396..3463400 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3463413..3463601) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" gene complement(3463413..3463601) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" downshifts complement(3463424) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" downshifts 3463591 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3463627..3463645) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3463638) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" promotor_-35 complement(3463659..3463665) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3463674..3464174) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" gene complement(3463674..3464174) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" promotor_-10 complement(3464210..3464229) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3464217) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" promotor_-35 complement(3464243..3464249) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3464309..3465442) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" gene complement(3464309..3465442) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" downshifts complement(3464327) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" misc_feature complement(3465469..3465488) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3465476) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" promotor_-10 complement(3465539..3465557) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3465555) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" promotor_-35 complement(3465571..3465578) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3465634..3466659) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" gene complement(3465634..3466659) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" downshifts complement(3465647) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" CDS complement(3466675..3467463) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" gene complement(3466675..3467463) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" promotor_-10 complement(3467489..3467508) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3467495) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" S_feature complement(3467497..3467708) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3467522..3467529) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3467709..3467870) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" gene complement(3467709..3467870) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" promotor_-10 complement(3467883..3467901) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3467903) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" promotor_-35 complement(3467915..3467921) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3467964..3468638) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" gene complement(3467964..3468638) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" downshifts complement(3467979) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" CDS complement(3468691..3468831) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" gene complement(3468691..3468831) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" CDS complement(3468962..3469645) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" gene complement(3468962..3469645) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" promotor_-35 3470022..3470026 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3470031..3471062) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" gene complement(3470031..3471062) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" promotor_-10 3470041..3470060 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3470047) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" upshifts 3470059 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3471090..3471108) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3471103) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" S_feature complement(3471105..3471222) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3471124..3471129) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3471164..3471169 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3471181..3473841 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3471181 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" promotor_-10 3471185..3471203 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3471258..3472568) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" gene complement(3471258..3472568) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" downshifts complement(3471267) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" promotor_-10 complement(3472592..3472611) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3472599) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" CDS complement(3472602..3473342) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" gene complement(3472602..3473342) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" promotor_-35 complement(3472625..3472634) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3472973) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" promotor_-10 complement(3472975..3472983) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3472997..3473005) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3473097..3473112) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3473105) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" promotor_-35 complement(3473125..3473134) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3473343..3473470) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3473471..3473701) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" gene complement(3473471..3473701) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" S_feature complement(3473702..3473964) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3473837..3473856 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3473843 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" CDS 3473871..3474344 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" gene 3473871..3474344 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" promotor_-10 complement(3473948..3473967) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3473964) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" S_feature complement(3473966..3474349) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3473982..3473985) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3474378..3474776) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" gene complement(3474378..3474776) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" downshifts complement(3474394) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" promotor_-10 complement(3474768..3474786) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3474777) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" promotor_-35 complement(3474800..3474806) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3474800..3476221) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" gene complement(3474800..3476221) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" CDS complement(3476247..3477110) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" gene complement(3476247..3477110) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" S_feature complement(3477111..3477186) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3477187..3478695) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" gene complement(3477187..3478695) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" CDS complement(3478712..3479257) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" gene complement(3478712..3479257) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" CDS complement(3479254..3479766) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" gene complement(3479254..3479766) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" S_feature complement(3479767..3479928) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3479929..3480141) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" gene complement(3479929..3480141) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" CDS complement(3480187..3480921) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" gene complement(3480187..3480921) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" promotor_no_box 3480735..3480835 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3480795 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3480929..3481312) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" gene complement(3480929..3481312) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" misc_feature complement(3481001..3481019) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3481003) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" S_feature complement(3481313..3481583) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3481545..3481554 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3481554 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3481559..3481578) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3481568..3481587 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3481583) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" S_feature complement(3481585..3481706) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3481591..3481598) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3481735..3482364) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" gene complement(3481735..3482364) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" downshifts complement(3481751) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" promotor_-10 complement(3482408..3482427) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3482431) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" promotor_-35 complement(3482442..3482449) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3482499..3483746) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" gene complement(3482499..3483746) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" downshifts complement(3482522) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(3483788..3483807) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3483805) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" S_feature complement(3483807..3483891) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3483822..3483827) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3483936) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" CDS complement(3483953..3484495) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" gene complement(3483953..3484495) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" CDS complement(3484508..3484957) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" gene complement(3484508..3484957) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" S_feature complement(3484958..3485057) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3485049..3485068) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3485057) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" promotor_-35 complement(3485082..3485089) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3485114..3485566) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" gene complement(3485114..3485566) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" promotor_-10 complement(3485583..3485602) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3485601) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" promotor_-35 complement(3485617..3485620) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3485642..3486199) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" gene complement(3485642..3486199) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" promotor_-10 complement(3486226..3486244) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3486239) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" promotor_-35 complement(3486260..3486265) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3486278..3487318) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" gene complement(3486278..3487318) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" downshifts complement(3486283) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" S_feature complement(3487319..3487383) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3487373..3487392) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3487383) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" S_feature complement(3487385..3487474) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3487408..3487412) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3487475..3487918) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" gene complement(3487475..3487918) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" CDS complement(3487985..3488659) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" gene complement(3487985..3488659) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" promotor_-10 complement(3488421..3488439) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3488428) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" promotor_-35 complement(3488454..3488460) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3488691..3488708) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3488692) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" promotor_-35 complement(3488724..3488729) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3488765 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" misc_feature 3488769..3488788 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3488800..3489162 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" gene 3488800..3489162 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" downshifts complement(3489175) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" CDS complement(3489179..3489466) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" gene complement(3489179..3489466) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" S_feature complement(3489467..3489525) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3489523..3489542) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3489526..3490392) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" gene complement(3489526..3490392) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" upshifts complement(3489539) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" promotor_-35 complement(3489555..3489564) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3490394..3491464) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" gene complement(3490394..3491464) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" downshifts complement(3490397) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" downshifts 3491465 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" promotor_-10 complement(3491492..3491511) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3491516) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" S_feature complement(3491518..3491629) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3491525..3491531) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3491561..3491580 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3491575 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" CDS 3491590..3491976 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" gene 3491590..3491976 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" promotor_-10 complement(3491611..3491629) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3491629) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" promotor_-35 complement(3491643..3491650) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3492044..3492052 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3492063..3492081 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3492064 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" CDS 3492098..3492652 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" gene 3492098..3492652 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" misc_feature 3492582..3492586 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3492587 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3492631 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" CDS complement(3492686..3493645) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" gene complement(3492686..3493645) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" downshifts complement(3492708) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(3493683..3493701) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3493697) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" promotor_-35 complement(3493716..3493722) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3493727..3495475) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" gene complement(3493727..3495475) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" promotor_-10 complement(3494201..3494219) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3494209) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" promotor_-35 complement(3494234..3494240) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3495476..3495566) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3495550..3495569) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3495566) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" promotor_-35 complement(3495583..3495590) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3495709) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" CDS complement(3495714..3496301) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" gene complement(3495714..3496301) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" CDS complement(3496390..3496590) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" gene complement(3496390..3496590) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" downshifts complement(3496403) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" S_feature complement(3496591..3496668) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3496664..3496683) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3496668) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" promotor_-35 complement(3496697..3496704) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3496709..3497992) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" gene complement(3496709..3497992) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" S_feature complement(3497993..3498295) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3498023..3498184) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" gene complement(3498023..3498184) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" promotor_-10 complement(3498275..3498294) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3498295) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" promotor_-35 complement(3498310..3498314) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3498399..3499364) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" gene complement(3498399..3499364) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" downshifts complement(3498405) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" promotor_-35 3498981..3498990 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3499003..3499022 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3499011 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3499395..3500684) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" gene complement(3499395..3500684) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" S_feature complement(3500685..3501044) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3501063..3501701) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" gene complement(3501063..3501701) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" downshifts complement(3501089) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" S_feature complement(3501702..3501820) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3501821..3502678) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" gene complement(3501821..3502678) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" S_feature complement(3502679..3502805) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3502787..3502806) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3502805) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" promotor_-35 complement(3502820..3502827) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3502859..3503233) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" gene complement(3502859..3503233) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" promotor_-10 complement(3503273..3503291) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3503287) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" S_feature complement(3503289..3503928) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3503290..3503293 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3503302..3503310) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3503309..3503328 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3503322 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" promotor_-35 3503336..3503341 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3503357..3503376 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3503367 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" CDS 3503399..3503920 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" gene 3503399..3503920 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" promotor_-35 3503863..3503866 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3503881..3503900 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3503895 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3503918..3503937) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3503928) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" downshifts 3503939 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" promotor_-35 complement(3503952..3503959) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3504002..3505609) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" gene complement(3504002..3505609) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" downshifts complement(3504015) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" S_feature complement(3505610..3505797) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3505785..3505804) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3505797) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" promotor_-35 complement(3505819..3505826) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3505851..3506372) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" gene complement(3505851..3506372) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" downshifts complement(3505907) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" S_feature complement(3506373..3506475) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3506456..3506475) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3506475) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" S_feature complement(3506477..3506554) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3506491..3506494) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3506555..3507694) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" gene complement(3506555..3507694) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" CDS complement(3507691..3509808) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" gene complement(3507691..3509808) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" S_feature complement(3509809..3509867) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3509868..3509887) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3509881) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" promotor_-35 complement(3509901..3509908) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3509907..3509913 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3509927..3509938 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3509932 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" CDS 3509963..3511159 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" gene 3509963..3511159 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" S_feature complement(3510155..3511033) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3511023..3511041) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3511034) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" promotor_-35 complement(3511057..3511062) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3511172..3512134 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" gene 3511172..3512134 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" promotor_-35 3512148..3512154 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3512169..3512187 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3512169 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" CDS 3512215..3512487 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" gene 3512215..3512487 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" downshifts complement(3512221) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" downshifts 3512477 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" S_feature 3512522..3512928 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3512529..3513053) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" gene complement(3512529..3513053) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" downshifts complement(3512551) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" CDS complement(3513063..3514790) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" gene complement(3513063..3514790) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" promotor_-10 complement(3514824..3514843) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3514838) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" promotor_-35 complement(3514857..3514863) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3514879..3516381) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" gene complement(3514879..3516381) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" promotor_-10 complement(3516405..3516423) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3516423) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" promotor_-35 complement(3516438..3516444) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3516468..3516840) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3516511) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" CDS complement(3516867..3517538) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" gene complement(3516867..3517538) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" downshifts complement(3516885) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" CDS complement(3517535..3518089) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" gene complement(3517535..3518089) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" CDS complement(3518115..3519578) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" gene complement(3518115..3519578) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" CDS complement(3519568..3523254) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" gene complement(3519568..3523254) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" misc_feature complement(3523285..3523304) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3523309) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" S_feature complement(3523311..3523440) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3523450..3523926) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" gene complement(3523450..3523926) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" downshifts complement(3523485) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" promotor_-10 complement(3523949..3523968) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3523961) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" promotor_-35 complement(3523983..3523986) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3524033 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" misc_feature 3524036..3524055 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3524070..3524789 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" gene 3524070..3524789 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" downshifts 3524773 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" CDS complement(3524821..3525537) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" gene complement(3524821..3525537) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" downshifts complement(3524823) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" downshifts complement(3524893) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" misc_feature complement(3525563..3525582) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3525575) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" CDS complement(3525636..3526823) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" gene complement(3525636..3526823) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" misc_feature complement(3526853..3526872) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3526871) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" CDS complement(3526959..3528629) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" gene complement(3526959..3528629) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" downshifts complement(3526961) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" CDS complement(3528626..3529054) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" gene complement(3528626..3529054) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" misc_feature 3529122..3529136 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3529122..3529141) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3529129 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(3529138) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" promotor_-35 complement(3529158..3529161) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3529193..3529212) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3529205) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" promotor_-35 3529285..3529292 /Source="Nicolas_upshift_promotors" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3529300 /Source="Nicolas_upshifts" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" promotor_-10 3529305..3529324 /Source="Nicolas_upshift_promotors" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 3529349 /Source="Nicolas_upshifts" /id="D1933" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="8.77621" /MaxDrop="1.77243" /score="6.03938699" /energy="-13.2" /TU="U2943" /idTUdmin="U2937" /TUdmin=4576 /isTUend="FALSE" CDS 3529367..3529498 /gene="sboA" /locus_tag="BSU_37350" /old_locus_tag="BSU37350" /function="16.8: Protect" /function="16.4: Excrete" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12696888, 15743949, 16095584, 17213266, 27914001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12696888, 15743949, 16095584, 17213266, 27914001; Product type f: factor" /codon_start=1 /transl_table=11 /product="subtilosin A" /protein_id="NP_391616.1" /db_xref="EnsemblGenomes-Gn:BSU37350" /db_xref="EnsemblGenomes-Tr:CAB15763" /db_xref="GOA:O07623" /db_xref="InterPro:IPR021539" /db_xref="PDB:1PXQ" /db_xref="SubtiList:BG12671" /db_xref="UniProtKB/Swiss-Prot:O07623" /translation="MKKAVIVENKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG* " gene 3529367..3529498 /gene="sboA" /locus_tag="BSU_37350" /old_locus_tag="BSU37350" CDS 3529455..3529607 /gene="sboX" /locus_tag="BSU_37360" /old_locus_tag="BSU37360" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin-like product" /protein_id="YP_054594.1" /db_xref="EnsemblGenomes-Gn:BSU37360" /db_xref="EnsemblGenomes-Tr:CAE01468" /db_xref="SubtiList:BG14182" /db_xref="UniProtKB/Swiss-Prot:Q7WY57" /translation="MKLPVQQVYSVYGGKDLPKGHSHSTMPFLSKLQFLTKIYLLDIH TQPFFI*" gene 3529455..3529607 /gene="sboX" /locus_tag="BSU_37360" /old_locus_tag="BSU37360" downshifts 3529487 /Source="Nicolas_upshifts" /id="D1934" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="8.85351" /MaxDrop="5.1396" /score="6.03938699" /energy="-13.2" /TU="U2943" /idTUdmin="U2937" /TUdmin=4714 /isTUend="FALSE" promotor_-35 3529602..3529608 /Source="Nicolas_upshift_promotors" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3529623..3529642 /Source="Nicolas_upshift_promotors" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3529626 /Source="Nicolas_upshifts" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" CDS 3529632..3530978 /gene="albA" /locus_tag="BSU_37370" /old_locus_tag="BSU37370" /EC_number="1.21.98.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066831, 15743949, 22366720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066831, 15743949, 22366720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subtilosin A thioether formation enzyme" /protein_id="NP_391617.1" /db_xref="EnsemblGenomes-Gn:BSU37370" /db_xref="EnsemblGenomes-Tr:CAB15764" /db_xref="GOA:P71011" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR008792" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017200" /db_xref="InterPro:IPR023885" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG12471" /db_xref="UniProtKB/Swiss-Prot:P71011" /translation="MFIEQMFPFINESVRVHQLPEGGVLEIDYLRDNVSISDFEYLDL NKTAYELCMRMDGQKTAEQILAEQCAVYDESPEDHKDWYYDMLNMLQNKQVIQLGNRA SRHTITTSGSNEFPMPLHATFELTHRCNLKCAHCYLESSPEALGTVSIEQFKKTADML FDNGVLTCEITGGEIFVHPNANEILDYVCKKFKKVAVLTNGTLMRKESLELLKTYKQK IIVGISLDSVNSEVHDSFRGRKGSFAQTCKTIKLLSDHGIFVRVAMSVFEKNMWEIHD MAQKVRDLGAKAFSYNWVDDFGRGRDIVHPTKDAEQHRKFMEYEQHVIDEFKDLIPII PYERKRAANCGAGWKSIVISPFGEVRPCALFPKEFSLGNIFHDSYESIFNSPLVHKLW QAQAPRFSEHCMKDKCPFSGYCGGCYLKGLNSNKYHRKNICSWAKNEQLEDVVQLI*" gene 3529632..3530978 /gene="albA" /locus_tag="BSU_37370" /old_locus_tag="BSU37370" CDS 3530991..3531152 /gene="albB" /locus_tag="BSU_37380" /old_locus_tag="BSU37380" /function="16.4: Excrete" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809709, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809709, 15743949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane component involved in subtilosin production" /protein_id="NP_391618.1" /db_xref="EnsemblGenomes-Gn:BSU37380" /db_xref="EnsemblGenomes-Tr:CAB15765" /db_xref="GOA:P71010" /db_xref="SubtiList:BG12470" /db_xref="UniProtKB/Swiss-Prot:P71010" /translation="MSPAQRRILLYILSFIFVIGAVVYFVKSDYLFTLIFIAIAILFG MRARKADSR*" gene 3530991..3531152 /gene="albB" /locus_tag="BSU_37380" /old_locus_tag="BSU37380" CDS 3531149..3531868 /gene="albC" /locus_tag="BSU_37390" /old_locus_tag="BSU37390" /function="16.5: Explore" /function="16.6: Maintain" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15743949; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter involved in subtilosin production" /protein_id="NP_391619.1" /db_xref="EnsemblGenomes-Gn:BSU37390" /db_xref="EnsemblGenomes-Tr:CAB15766" /db_xref="GOA:P71009" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12469" /db_xref="UniProtKB/Swiss-Prot:P71009" /translation="MSILDIHDVSVWYERDNVILEQVDLHLEKGAVYGLLGVNGAGKT TLINTLTGVNRNFSGRFTLCGIEAEAGMPQKTSDQLKTHRYFAADYPLLFTEITAKDY VSFVHSLYQKDFSEQQFASLAEAFHFSKYINRRISELSLGNRQKVVLMTGLLLRAPLF ILDEPLVGLDVESIEVFYQKMREYCEAGGTILFSSHLLDVVQRFCDYAAILHNKQIQK VIPIGEETDLRREFFEVIGHE*" gene 3531149..3531868 /gene="albC" /locus_tag="BSU_37390" /old_locus_tag="BSU37390" CDS 3531861..3533171 /gene="albD" /locus_tag="BSU_37400" /old_locus_tag="BSU37400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10809709, 15066831, 15743949, 15849754, 16850406, 18034824; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral membrane protein involved in subtilosinproduction and immunity" /protein_id="NP_391620.1" /db_xref="EnsemblGenomes-Gn:BSU37400" /db_xref="EnsemblGenomes-Tr:CAB15767" /db_xref="GOA:P71008" /db_xref="SubtiList:BG12468" /db_xref="UniProtKB/Swiss-Prot:P71008" /translation="MNNIIPIMSLLFKQLYSRQGKKDAIRIAAGLVILAVFEIGLIRQ AGIDESVLRKTYIILALLLMNTYMVFLSVTSQWKESYMKLSCLLPISSRSFWLAQSVV LFVDTCLRRTLFFFILPLFLFGNGTLSGAQTLFWLGRFSFFTVYSIIFGVVLSNHFVK KKNLMFLLHAAIFACVCISAALMPAATIPLCAVHILWAVVIDFPVFLQAPPQQGKMHS FMRRSEFSFYKREWNRFISSKAMLLNYAVMAVFSGFFSFQMMNTGIFNQQVIYIVISA LLLICSPIALLYSIEKNDRMLLITLPIKRKTMFWAKYRFYSGLLAGGFLLVVMIVGFI SGRSISVLTFLQCIELLLAGAYIRLTADEKRPSFSWQTEQQLWSGFSKYRSYLFCLPL FLAILAGTAVSLAVIPIAGLVIVYYLQKQDGGFFDTSKRERLGS*" gene 3531861..3533171 /gene="albD" /locus_tag="BSU_37400" /old_locus_tag="BSU37400" CDS 3533161..3534321 /gene="albE" /locus_tag="BSU_37410" /old_locus_tag="BSU37410" /function="16.8: Protect" /function="16.5: Explore" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10809709, 15066831, 15743949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase involved in subtilosin A production" /protein_id="NP_391621.1" /db_xref="EnsemblGenomes-Gn:BSU37410" /db_xref="EnsemblGenomes-Tr:CAB15768" /db_xref="GOA:P71007" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG12467" /db_xref="UniProtKB/Swiss-Prot:P71007" /translation="MEVNLLKTHQFSTISIAASFLKPIESAAEPEEETIYFYGAAAYL KEQIIDAFGYAAGSRFMYSANLFFDQQLKTCGTRLIHPLYNGNLHVDALMKTFADLSF PSSLSFEAFEKARNELLLKIEKKFTDPFSYSAARLAEEVFGNPMYGTGMFGRRDRIKA IHPKRFLDATDFIVDLVSQQKQLNILGQVQACDVRGHAPQTSAVTSGRIPVNRHVFET ETRSAAGPSVLTLGFDCGEMKDASDYIKIQLIDGLLGKYGHSALFKHFREKDLAVYHV ITRYDVMNNLLLVSICTDQLHEKDIPPRVLEAVSAFHTDERELEQAKQFLRNELLLQF DSPEGLLAYMGVLRRFSCTKEALLDGISAVTCRDVLQFIATINYIGAHVVRG*" gene 3533161..3534321 /gene="albE" /locus_tag="BSU_37410" /old_locus_tag="BSU37410" CDS 3534326..3535606 /gene="albF" /locus_tag="BSU_37420" /old_locus_tag="BSU37420" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.4: Excrete" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15743949, 25817994; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase involved in subtilosin production" /protein_id="NP_391622.1" /db_xref="EnsemblGenomes-Gn:BSU37420" /db_xref="EnsemblGenomes-Tr:CAB15769" /db_xref="GOA:P71006" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG12466" /db_xref="UniProtKB/Swiss-Prot:P71006" /translation="MEKKAFFQQLDERTDIRYTDSGLKIFRLKFPRAHLRLCNVKIDF GSRDVCIRAESGDTLLPYGTAHFLEHLLFWHNGRNLYSDFFAHGALLNAFTTYTDTNF MFTSLPDRLRQTIPILLDALWNHSFDKKIVAQEKAVITSEIQTAHLNHQLSYHYQLIS MLSPSSPAAVFPAGRIEDIEALDISDLQKAYKAAYQAHRMTLFLIGGSENTETLLPPH LQLEKRPDYHAERKIIPACPPVLSQKMMLGDEERMEDTWTGLQIGALPGQNDLLSIKL YWDIAARILFQLDSPFFQEIQQTYRLEIDRLSAETYIYEDGGFLILHSQGTHSSAYID VASYYVTQKKEQVAAWLQYGKDSLTDAIIYDSDYVRKCFEWAAECDRCDCSFLDMYHI IQDMDAQVFLSLIDAMASSNKAIIHVSQKEAIRQ*" gene 3534326..3535606 /gene="albF" /locus_tag="BSU_37420" /old_locus_tag="BSU37420" CDS 3535603..3536304 /gene="albG" /locus_tag="BSU_37430" /old_locus_tag="BSU37430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein involved in subtilosin production and immunity" /protein_id="NP_391623.1" /db_xref="EnsemblGenomes-Gn:BSU37430" /db_xref="EnsemblGenomes-Tr:CAB15770" /db_xref="GOA:P71005" /db_xref="SubtiList:BG12465" /db_xref="UniProtKB/Swiss-Prot:P71005" /translation="MKQSTVFTLLLLLIGMAAYSFGWVQAVAEAAAQYVQMINNDAVR LGLLACTAALLMLPAFLYLHYVTQSVKNMTAAFQKLTQSHQSCCDFQQHNLCSRYAED VKSLRDSYKNVRQTYVMAAVLCQVIIFGCMFEIVKAVPFRLHTPPAFSMGLAMLLILY LLFCMRTYLRQLFRHGSLFRKVFAGALAAAGIWWMLSFSISELLFLIILAAIQQIGSF IYKRFSYHSTASLDL*" gene 3535603..3536304 /gene="albG" /locus_tag="BSU_37430" /old_locus_tag="BSU37430" downshifts complement(3535871) /Source="Nicolas_upshifts" /id="D1935" /incds=1 /nref=2 /ntot=5 /MaxReadThrough="0.362109999999999" /MaxDrop="3.55474" /score="6.50386958" /energy="-12" /TU="NA" /idTUdmin="U2945" /TUdmin=0 /isTUend="TRUE" S_feature complement(3535960..3536309) /Source="Nicolas_S_feature" /locus_tag="new_3842651_3843000_c" /HighExp="BT, B36, B60, Pyr, G/S, Mal, S3, G135, M/G, Sw" /AntisenseName="albG" /AntisenseCor="2.0087959212361201E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1449" downshifts complement(3536003) /Source="Nicolas_upshifts" /id="D1936" /incds=1 /nref=6 /ntot=18 /MaxReadThrough="3.01883" /MaxDrop="4.2137" /score="6.50386958" /energy="-12" /TU="U2945" /idTUdmin="U2945" /TUdmin="-132" /isTUend="FALSE" S_feature 3536305..3538787 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3536310..3537686) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" gene complement(3536310..3537686) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" CDS complement(3537725..3539080) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" gene complement(3537725..3539080) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" promotor_-10 complement(3539116..3539135) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3539134) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" promotor_-35 complement(3539148..3539157) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3539260..3539279 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3539261 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" downshifts complement(3539306) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" CDS 3539310..3540455 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" gene 3539310..3540455 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" promotor_-35 3540314..3540318 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3540335..3540354 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3540342 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" downshifts complement(3540425) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" CDS 3540439..3540558 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" gene 3540439..3540558 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" downshifts 3540543 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" S_feature 3540588..3540656 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3540657..3541130 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" gene 3540657..3541130 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" downshifts 3541119 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" CDS complement(3541162..3542034) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" gene complement(3541162..3542034) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" downshifts complement(3541173) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" downshifts complement(3541239) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" CDS complement(3542095..3542925) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" gene complement(3542095..3542925) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" S_feature complement(3542926..3543021) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3543009..3543028) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3543020) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" promotor_-35 complement(3543041..3543048) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3543066..3543071 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3543087..3543105 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3543089 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" CDS 3543127..3545202 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" gene 3543127..3545202 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" downshifts complement(3545255) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" S_feature complement(3545379..3545494) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3545422) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" CDS complement(3545495..3546013) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" gene complement(3545495..3546013) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" CDS complement(3546027..3546686) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" gene complement(3546027..3546686) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" promotor_-35 3546709..3546712 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3546722..3546741) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3546727..3546746 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3546730 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" upshifts complement(3546740) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" S_feature complement(3546742..3547025) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3546756..3546763) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3546795..3546983 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" gene 3546795..3546983 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" downshifts 3546972 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" CDS complement(3547026..3547445) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" gene complement(3547026..3547445) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" promotor_-10 complement(3547495..3547514) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3547506) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" promotor_-35 complement(3547529..3547536) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3547565..3549481) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" gene complement(3547565..3549481) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" promotor_-10 complement(3548759..3548777) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3548764) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3548794..3548798) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3549512) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" misc_RNA complement(3549535..3549756) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" gene complement(3549535..3549756) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" misc_RNA complement(3549788..3550009) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" gene complement(3549788..3550009) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" S_feature complement(3550041..3550303) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3550052 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" downshifts complement(3550084) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" CDS complement(3550091..3550246) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" gene complement(3550091..3550246) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" promotor_-35 3550253..3550256 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3550265..3550278 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3550272 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3550280..3550299) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3550303) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" promotor_-35 complement(3550313..3550319) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3550326..3551726) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" gene complement(3550326..3551726) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" CDS complement(3551726..3552196) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" gene complement(3551726..3552196) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" downshifts complement(3552152) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" CDS complement(3552308..3552808) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" gene complement(3552308..3552808) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" downshifts complement(3552311) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" CDS complement(3552844..3554145) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" gene complement(3552844..3554145) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" promotor_-10 complement(3554169..3554188) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3554183) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" S_feature complement(3554185..3554306) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3554204..3554206) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3554307..3554531) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" gene complement(3554307..3554531) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" S_feature complement(3554532..3554616) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3554605..3554624) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3554615) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" promotor_-35 complement(3554639..3554642) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3554682..3554688 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3554703..3554714 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3554704 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" CDS 3554746..3555522 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" gene 3554746..3555522 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" downshifts 3555508 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" promotor_-35 3555610..3555617 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3555632..3555651 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3555636..3559862 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3555636 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" CDS complement(3555666..3556556) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" gene complement(3555666..3556556) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" promotor_no_box complement(3556556..3556656) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3556596) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" CDS complement(3556724..3557569) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" gene complement(3556724..3557569) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" downshifts complement(3556887) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" CDS complement(3557618..3558517) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" gene complement(3557618..3558517) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" promotor_-10 complement(3558560..3558579) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3558563) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" promotor_-35 complement(3558593..3558600) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3558664) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" CDS complement(3558664..3559635) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" gene complement(3558664..3559635) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" promotor_-10 complement(3559670..3559689) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3559695) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" promotor_-35 complement(3559705..3559709) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3559783..3559794) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3559786) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" promotor_-35 complement(3559808..3559814) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3559857..3559876 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3559864 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" CDS 3559905..3560669 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" gene 3559905..3560669 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" downshifts 3560656 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" promotor_-35 3560732..3560738 /Source="Nicolas_upshift_promotors" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3560752..3560771 /Source="Nicolas_upshift_promotors" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3560761 /Source="Nicolas_upshifts" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" CDS 3560802..3561581 /gene="bacG" /locus_tag="BSU_37680" /old_locus_tag="BSU37680" /EC_number="1.3.1.-" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:12372825, 20052993, 23519407, 25644640" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 20052993, 23519407, 25644640; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclohexenol-containing tetrahydro-4-hydroxyphenylpyruvate H(4)HPP in bacilysin synthesis" /protein_id="NP_391648.1" /db_xref="EnsemblGenomes-Gn:BSU37680" /db_xref="EnsemblGenomes-Tr:CAB15795" /db_xref="GOA:P39644" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3U49" /db_xref="PDB:3U4C" /db_xref="PDB:3U4D" /db_xref="SubtiList:BG10632" /db_xref="UniProtKB/Swiss-Prot:P39644" /translation="MSKRTAFVMGASQGIGKAIALKLADQHFSLVINSRNLDNIESVK EDILAKHPEASVIVLAGDMSDQHTRAGIFQKIESQCGRLDVLINNIPGGAPDTFDNCN IEDMTATFTQKTVAYIDAIKRASSLMKQNEFGRIINIVGNLWKEPGANMFTNSMMNAA LINASKNISIQLAPHNITVNCLNPGFIATDRYHQFVENVMKKNSISKQKAEEQIASGI PMKRVGSAEETAALAAFLASEEASYITGQQISADGGSMKSI*" gene 3560802..3561581 /gene="bacG" /locus_tag="BSU_37680" /old_locus_tag="BSU37680" downshifts 3561558 /Source="Nicolas_upshifts" /id="D1955" /incds=0 /nref=84 /ntot=226 /MaxReadThrough="3.12719" /MaxDrop="4.87473" /score="3.07615905" /energy="-11.9" /TU="U2965" /idTUdmin="U2964" /TUdmin=0 /isTUend="TRUE" CDS complement(3561596..3562795) /gene="bacF" /locus_tag="BSU_37690" /old_locus_tag="BSU37690" /function="16.4: Excrete" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 12670965, 15609023, 20052993, 18957859, 19061923, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 12670965, 15609023, 20052993, 18957859, 19061923, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanine aminotransferase forming tetrahydrotyrosine in bacilysin synthesis" /protein_id="NP_391649.1" /db_xref="EnsemblGenomes-Gn:BSU37690" /db_xref="EnsemblGenomes-Tr:CAB15796" /db_xref="GOA:P39643" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10631" /db_xref="UniProtKB/Swiss-Prot:P39643" /translation="MEITPSDVIKTLPRQEFSLVFQKVKEMEKTGAHIINLGQGNPDL PTPPHIVEALREASLNPSFHGYGPFRGYPFLKEAIAAFYKREYGVTINPETEVALFGG GKAGLYVLTQCLLNPGDIALVPNPGYPEYLSGITMARAELYEMPLYEENGYLPDFEKI DPAVLEKAKLMFLNYPNNPTGAVADAAFYAKAAAFAKEHNIHLIHDFAYGAFEFDQKP ASFLEAEDAKTVGAELYSFSKTFNMAGWRMAFAVGNEKIIQAVNEFQDHVFVGMFGGL QQAASAALSGDPEHTESLKRIYKERIDFFTALCEKELGWKMEKPKGTFYVWAEIPNTF ETSHQFSDYLLEHAHVVVTPGEIFGSNGKRHVRISMVSKQEDLREFVTRIQKLNLPFG SLQETSR*" gene complement(3561596..3562795) /gene="bacF" /locus_tag="BSU_37690" /old_locus_tag="BSU37690" CDS complement(3562796..3563980) /gene="bacE" /locus_tag="BSU_37700" /old_locus_tag="BSU37700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 15849754, 16850406, 18957859, 19061923, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 15849754, 16850406, 18957859, 19061923, 25261512, 25472439, 26284661; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux protein for bacilysin excretion, self-protection against bacilysin" /protein_id="NP_391650.1" /db_xref="EnsemblGenomes-Gn:BSU37700" /db_xref="EnsemblGenomes-Tr:CAB15797" /db_xref="GOA:P39642" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR022324" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10630" /db_xref="UniProtKB/Swiss-Prot:P39642" /translation="MKQLKPNSKYLLYGQALSFMGDYCVLPALLILSTYYHDYWVTSG VIVVRSIPMVFQPFLGVLVDRLDRIKIMLWTDIIRGIIFLGLTFLPKGEYPLIFLALL FITYGSGVFFNPARLAVMSSLESDIKSINTLFAKATTISIIVGAAAGGLFLLGGSVEL AVAFNGVTYLVSAFFISRIKLQFVPIQSENIKEAFQSFKEGLKEIKTNSFVLNAMFTM ITMALLWGVVYSYFPIVSRFLGDGEIGNFILTFCIGFGGFIGAALVSKWGFNNNRGLT YFTVLSIVSLALFLFTPIFAVSVIAAILFFIAMEYGEVLAKVKVQENAANQIQGRIFS VAEASIGLCISIGSMFINILSAPVIMGLIVVIVCGLFLHTKLVNKSFLERDNKTEQKG VF*" gene complement(3562796..3563980) /gene="bacE" /locus_tag="BSU_37700" /old_locus_tag="BSU37700" CDS complement(3563977..3565395) /gene="bacD" /locus_tag="BSU_37710" /old_locus_tag="BSU37710" /EC_number="6.3.2.49" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15609023, 16030213, 18957859, 19061923, 22298000, 22407814, 24702628, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15609023, 16030213, 18957859, 19061923, 22298000, 22407814, 24702628, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine-anticapsin ligase" /protein_id="NP_391651.1" /db_xref="EnsemblGenomes-Gn:BSU37710" /db_xref="EnsemblGenomes-Tr:CAB15798" /db_xref="GOA:P39641" /db_xref="InterPro:IPR011761" /db_xref="PDB:3VMM" /db_xref="PDB:3WNZ" /db_xref="PDB:3WO0" /db_xref="PDB:3WO1" /db_xref="SubtiList:BG10629" /db_xref="UniProtKB/Swiss-Prot:P39641" /translation="MERKTVLVIADLGGCPPHMFYKSAAEKYNLVSFIPRPFAITASH AALIEKYSVAVIKDKDYFKSLADFEHPDSIYWAHEDHNKPEEEVVEQIVKVAEMFGAD AITTNNELFIAPMAKACERLGLRGAGVQAAENARDKNKMRDAFNKAGVKSIKNKRVTT LEDFRAALEEIGTPLILKPTYLASSIGVTLITDTETAEDEFNRVNDYLKSINVPKAVT FEAPFIAEEFLQGEYGDWYQTEGYSDYISIEGIMADGEYFPIAIHDKTPQIGFTETSH ITPSILDEEAKKKIVEAAKKANEGLGLQNCATHTEIKLMKNREPGLIESAARFAGWNM IPNIKKVFGLDMAQLLLDVLCFGKDADLPDGLLDQEPYYVADCHLYPQHFKQNGQIPE TAEDLVIEAIDIPDGLLKGDTEIVSFSAAAPGTSVDLTLFEAFNSIAAFELKGSNSQD VAESIRQIQQHAKLTAKYVLPV*" gene complement(3563977..3565395) /gene="bacD" /locus_tag="BSU_37710" /old_locus_tag="BSU37710" CDS complement(3565414..3566175) /gene="bacC" /locus_tag="BSU_37720" /old_locus_tag="BSU37720" /EC_number="1.1.1.385" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 18957859, 19061923, 23317005, 25261512, 25472439, 26284661, 28158843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 18957859, 19061923, 23317005, 25261512, 25472439, 26284661, 28158843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroanticapsin 7-dehydrogenase" /protein_id="NP_391652.2" /db_xref="EnsemblGenomes-Gn:BSU37720" /db_xref="EnsemblGenomes-Tr:CAB15799" /db_xref="GOA:P39640" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="PDB:5ITV" /db_xref="PDB:5ITW" /db_xref="SubtiList:BG10628" /db_xref="UniProtKB/Swiss-Prot:P39640" /translation="MNLTDKTVLITGGASGIGYAAVQAFLGQQANVVVADIDEAQGEA MVRKENNDRLHFVQTDITDEAACQHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELS DWNKVLQVNLTGMFLMSKHALKHMLAAGKGNIINTCSVGGLVAWPDIPAYNASKGGVL QLTKSMAVDYAKHQIRVNCVCPGIIDTPLNEKSFLENNEGTLEEIKKEKAKVNPLLRL GKPEEIANVMLFLASDLSSYMTGSAITADGGYTAQ*" gene complement(3565414..3566175) /gene="bacC" /locus_tag="BSU_37720" /old_locus_tag="BSU37720" CDS complement(3566178..3566885) /gene="bacB" /locus_tag="BSU_37730" /old_locus_tag="BSU37730" /EC_number="5.3.3.19" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 14697267, 15609023, 15628860, 18957859, 19061923, 19776011, 20445239, 22483065, 22765234, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 14697267, 15609023, 15628860, 18957859, 19061923, 19776011, 20445239, 22483065, 22765234, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-((4R)-4-hydroxycyclohexa-1, 5-dien-1-yl)-2-oxopropanoate isomerase" /protein_id="NP_391653.1" /db_xref="EnsemblGenomes-Gn:BSU37730" /db_xref="EnsemblGenomes-Tr:CAB15800" /db_xref="GOA:P39639" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:3H7J" /db_xref="PDB:3H7Y" /db_xref="PDB:3H9A" /db_xref="SubtiList:BG10627" /db_xref="UniProtKB/Swiss-Prot:P39639" /translation="MKTKEDMQELYFPTPKLIEWENGVRQYSTVRGDTEVLMSYVPPH TNVEPHQHKEVQIGMVVSGELMMTVGDVTRKMTALESAYIAPPHVPHGARNDTDQEVI AIDIKRLKADETYTSPEDYFLDIFKTRDLLPGMEVTFFVEDWVEIMLAKIPGNGGEMP FHKHRNEQIGICIGGGYDMTVEGCTVEMKFGTAYFCEPREDHGAINRSEKESKSINIF FPPRYNRAKAKKMKADE*" gene complement(3566178..3566885) /gene="bacB" /locus_tag="BSU_37730" /old_locus_tag="BSU37730" misc_feature complement(3566781..3566782) /Source="Nicolas_upshift_promotors" /id="U2966" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.346653346653347" /xcortree=314 /SigmaFactorBS="cgaaattaattgaatgggaaaacggagtgaggcagtattcaa ccgtacgaggggatactgAAgtattaatgtcttacgtcccgccgcataccaatgttga a" /listShort="bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3566782) /Source="Nicolas_upshifts" /id="U2966" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.346653346653347" /xcortree=314 /SigmaFactorBS="cgaaattaattgaatgggaaaacggagtgaggcagtattcaa ccgtacgaggggatactgAAgtattaatgtcttacgtcccgccgcataccaatgttga a" /listShort="bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" CDS complement(3566875..3567489) /gene="bacA" /locus_tag="BSU_37740" /old_locus_tag="BSU37740" /EC_number="4.1.1.100" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 19776011, 18957859, 19061923, 20052993, 20863139, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 19776011, 18957859, 19061923, 20052993, 20863139, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate decarboxylase" /protein_id="NP_391654.1" /db_xref="EnsemblGenomes-Gn:BSU37740" /db_xref="EnsemblGenomes-Tr:CAB15801" /db_xref="GOA:P39638" /db_xref="SubtiList:BG10626" /db_xref="UniProtKB/Swiss-Prot:P39638" /translation="MIILDNSIQTKKRTDSLSKLITVNTLGPEGTSSEYAAKHFISNF TLLQGLNSKLSLHDTFESCIERTLQSPLEYTIVPHAYDGIKHFYMRPDLQLLQIFRCD TPMYGLAVRPDFEFRDDMLDTSVIVSHPSPINLIKYFTRKDVRFKLVNSTSQAARKVK EGLYDIALTNELARQKYGLTFVKTFKSIPMSWSLFGKGDVDDEN*" gene complement(3566875..3567489) /gene="bacA" /locus_tag="BSU_37740" /old_locus_tag="BSU37740" promotor_-35 3567047..3567053 /Source="Nicolas_upshift_promotors" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3567069..3567087 /Source="Nicolas_upshift_promotors" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3567080..3567691 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" upshifts 3567080 /Source="Nicolas_upshifts" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" promotor_-10 complement(3567512..3567531) /Source="Nicolas_upshift_promotors" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3567528) /Source="Nicolas_upshifts" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" promotor_-35 complement(3567546..3567553) /Source="Nicolas_upshift_promotors" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3567640) /Source="Nicolas_upshifts" /id="D1956" /incds=0 /nref=1 /ntot=33 /MaxReadThrough="2.28302" /MaxDrop="5.44594" /score="19.4538123" /energy="-5.1" /TU="NA" /idTUdmin="U2969" /TUdmin=902 /isTUend="FALSE" CDS complement(3567641..3568879) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" gene complement(3567641..3568879) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" promotor_-10 complement(3568921..3568940) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3568933) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" promotor_-35 complement(3568952..3568959) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3569089..3570501) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" gene complement(3569089..3570501) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" downshifts complement(3569096) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" CDS complement(3570501..3572201) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" gene complement(3570501..3572201) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" misc_feature complement(3571170..3571186) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3571182) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" CDS complement(3572275..3573822) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" gene complement(3572275..3573822) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" downshifts complement(3572282) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" upshifts complement(3573866) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" S_feature complement(3573868..3574048) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3573869..3573887) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3574049..3575323) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" gene complement(3574049..3575323) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" S_feature complement(3575324..3575406) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3575406) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" misc_feature complement(3575419..3575437) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3575499) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" CDS complement(3575500..3575964) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" gene complement(3575500..3575964) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" S_feature complement(3575965..3576075) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3576057..3576076) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3576075) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" promotor_-35 complement(3576091..3576098) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3576286) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" CDS complement(3576288..3576743) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" gene complement(3576288..3576743) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" misc_feature 3576378..3576397 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3576386 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3576736..3577587) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" gene complement(3576736..3577587) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" CDS complement(3577601..3578548) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" gene complement(3577601..3578548) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" CDS complement(3578548..3579288) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" gene complement(3578548..3579288) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" promotor_-35 3579306..3579311 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3579312 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3579313..3580332) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" gene complement(3579313..3580332) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" promotor_-10 3579326..3579344 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3580196..3580205 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3580218..3580233 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3580229 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3580335..3581057) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" gene complement(3580335..3581057) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" CDS complement(3581050..3582171) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" gene complement(3581050..3582171) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" CDS complement(3582171..3583040) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" gene complement(3582171..3583040) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" CDS complement(3583041..3584210) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" gene complement(3583041..3584210) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" CDS complement(3584231..3585655) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" gene complement(3584231..3585655) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" CDS complement(3585660..3586430) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" gene complement(3585660..3586430) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" promotor_-10 complement(3586465..3586484) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3586479) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" promotor_-35 complement(3586498..3586507) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3586598..3586603 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3586619..3586637 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3586621..3586749 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3586621 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" CDS 3586750..3587295 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" gene 3586750..3587295 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" downshifts 3587281 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" CDS complement(3587339..3587710) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" gene complement(3587339..3587710) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" downshifts complement(3587357) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" CDS complement(3587772..3589094) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" gene complement(3587772..3589094) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" CDS complement(3589114..3589431) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" gene complement(3589114..3589431) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" promotor_-10 complement(3589460..3589479) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3589471) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" promotor_-35 complement(3589493..3589499) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3589534..3589541 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3589557..3589576 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3589560 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" CDS 3589599..3590969 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" gene 3589599..3590969 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" CDS complement(3590994..3591671) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" gene complement(3590994..3591671) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" downshifts complement(3591008) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3591498..3591517) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3591514) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3591533..3591538) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3591685..3592491) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" gene complement(3591685..3592491) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" promotor_-10 complement(3591984..3592002) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3591998) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" promotor_-35 complement(3592017..3592023) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3592520..3592539) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3592526) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" promotor_-35 complement(3592555..3592562) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3592581..3593114) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" gene complement(3592581..3593114) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" CDS complement(3593162..3593797) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" gene complement(3593162..3593797) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" CDS complement(3593790..3594128) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" gene complement(3593790..3594128) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" promotor_-10 complement(3594150..3594169) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3594161) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" promotor_-35 complement(3594184..3594191) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3594212..3594215 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3594230..3594249 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3594230 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" CDS 3594272..3595087 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" gene 3594272..3595087 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" downshifts 3595066 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" downshifts complement(3595142) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" CDS complement(3595177..3595425) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" gene complement(3595177..3595425) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" downshifts complement(3595197) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" upshifts complement(3595443) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" S_feature complement(3595445..3595518) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3595453..3595459) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3595519..3596958) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" gene complement(3595519..3596958) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" CDS complement(3596955..3598340) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" gene complement(3596955..3598340) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" misc_feature complement(3598359..3598368) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3598373) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" S_feature complement(3598375..3598439) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3598418..3598435) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3598439) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" promotor_-35 complement(3598451..3598458) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3598481..3598500) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3598499) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" promotor_-35 complement(3598514..3598521) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3598580..3598583 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3598590 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" promotor_-10 3598598..3598617 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3598642..3599412 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" gene 3598642..3599412 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" S_feature 3599413..3600480 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3599451..3600281) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" gene complement(3599451..3600281) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" downshifts complement(3599452) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(3600307..3600326) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3600313) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" CDS complement(3600321..3600623) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" gene complement(3600321..3600623) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" promotor_-35 complement(3600341..3600348) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3600624..3600762) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3600747..3600766) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3600762) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" promotor_-35 3601077..3601085 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3601096..3601114 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3601097 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" CDS 3601153..3603573 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15205417, 15596354, 16946274, 17666034, 18689487, 25666135" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15205417, 15596354, 16946274, 17666034, 18689487, 25666135; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391688.1" /db_xref="EnsemblGenomes-Gn:BSU38090" /db_xref="EnsemblGenomes-Tr:CAB15835" /db_xref="GOA:P29141" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR025965" /db_xref="InterPro:IPR034213" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10591" /db_xref="UniProtKB/Swiss-Prot:P29141" /translation="MKKGIIRFLLVSFVLFFALSTGITGVQAAPASSKTSADLEKAEV FGDIDMTTSKKTTVIVELKEKSLAEAKEAGESQSKSKLKTARTKAKNKAIKAVKNGKV NREYEQVFSGFSMKLPANEIPKLLAVKDVKAVYPNVTYKTDNMKDKDVTISEDAVSPQ MDDSAPYIGANDAWDLGYTGKGIKVAIIDTGVEYNHPDLKKNFGQYKGYDFVDNDYDP KETPTGDPRGEATDHGTHVAGTVAANGTIKGVAPDATLLAYRVLGPGGSGTTENVIAG VERAVQDGADVMNLSLGNSLNNPDWATSTALDWAMSEGVVAVTSNGNSGPNGWTVGSP GTSREAISVGATQLPLNEYAVTFGSYSSAKVMGYNKEDDVKALNNKEVELVEAGIGEA KDFEGKDLTGKVAVVKRGSIAFVDKADNAKKAGAIGMVVYNNLSGEIEANVPGMSVPT IKLSLEDGEKLVSALKAGETKTTFKLTVSKALGEQVADFSSRGPVMDTWMIKPDISAP GVNIVSTIPTHDPDHPYGYGSKQGTSMASPHIAGAVAVIKQAKPKWSVEQIKAAIMNT AVTLKDSDGEVYPHNAQGAGSARIMNAIKADSLVSPGSYSYGTFLKENGNETKNETFT IENQSSIRKSYTLEYSFNGSGISTSGTSRVVIPAHQTGKATAKVKVNTKKTKAGTYEG TVIVREGGKTVAKVPTLLIVKEPDYPRVTSVSVSEGSVQGTYQIETYLPAGAEELAFL VYDSNLDFAGQAGIYKNQDKGYQYFDWDGTINGGTKLPAGEYYLLAYAANKGKSSQVL TEEPFTVE*" gene 3601153..3603573 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" upshifts 3601311 /Source="Nicolas_upshifts" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3601320..3601339 /Source="Nicolas_upshift_promotors" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3603561 /Source="Nicolas_upshifts" /id="D1968" /incds=0 /nref=7 /ntot=104 /MaxReadThrough="0.60305" /MaxDrop="5.33856" /score="26.8487936" /energy="-16.5" /TU="NA" /idTUdmin="U2993" /TUdmin=6 /isTUend="TRUE" CDS complement(3603611..3604612) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " gene complement(3603611..3604612) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" S_feature complement(3604613..3604774) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3604786..3605535) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" gene complement(3604786..3605535) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" downshifts complement(3604819) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" promotor_-10 complement(3605553..3605572) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3605570) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" promotor_-35 complement(3605587..3605590) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3605641..3606822) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" gene complement(3605641..3606822) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" downshifts complement(3605655) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" S_feature complement(3606823..3606954) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3606948..3606963) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3606954) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" promotor_-35 complement(3606975..3606984) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3607189..3607196 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3607207..3607317 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3607207..3607226 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3607207 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" CDS 3607318..3607581 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" gene 3607318..3607581 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" downshifts 3607471 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" downshifts 3607587 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" CDS complement(3607624..3607998) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" gene complement(3607624..3607998) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" downshifts complement(3607635) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" CDS complement(3608000..3608614) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" gene complement(3608000..3608614) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" CDS complement(3608628..3610577) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" gene complement(3608628..3610577) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" misc_feature 3609841..3609860 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3609847 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_no_box 3610271..3610371 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3610331 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3610441 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" CDS complement(3610605..3611570) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" gene complement(3610605..3611570) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" S_feature complement(3611571..3611639) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3611626..3611645) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3611639) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" S_feature complement(3611641..3611826) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3611658..3611662) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3611757..3611762 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3611778..3611796 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3611783 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3611817..3611836) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3611826) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" S_feature complement(3611828..3611937) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3611851..3611855) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3611893 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" promotor_-10 complement(3611922..3611941) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3611937) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" promotor_-35 complement(3611957..3611961) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3612015..3612033) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3612020..3612026 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3612032) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" promotor_-10 3612041..3612059 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3612044 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" promotor_-35 complement(3612049..3612054) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3612086..3612331 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" gene 3612086..3612331 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" downshifts 3612313 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" CDS complement(3612402..3613943) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" gene complement(3612402..3613943) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" downshifts complement(3612431) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" CDS complement(3613947..3615119) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" gene complement(3613947..3615119) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" promotor_-10 complement(3615137..3615155) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3615159) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" promotor_-35 complement(3615170..3615176) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3615200..3615583) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" gene complement(3615200..3615583) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" CDS complement(3615601..3616272) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" gene complement(3615601..3616272) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" promotor_-10 complement(3616294..3616313) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3616303) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" promotor_-35 complement(3616329..3616332) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3616413..3616416 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3616431..3616450 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3616440..3616627 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3616440 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" CDS 3616628..3616786 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" gene 3616628..3616786 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" S_feature 3616787..3617171 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3617152..3617157 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3617173..3617191 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3617173 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" CDS 3617229..3617537 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" gene 3617229..3617537 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" downshifts complement(3617315) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(3617319..3617419) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3617359) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3617534..3619075 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" gene 3617534..3619075 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" downshifts 3619066 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" CDS complement(3619106..3619708) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" gene complement(3619106..3619708) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" downshifts complement(3619120) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" S_feature complement(3619709..3619990) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3619991..3621241) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" gene complement(3619991..3621241) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" downshifts complement(3620087) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" CDS complement(3621260..3622417) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" gene complement(3621260..3622417) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" misc_feature complement(3621333..3621352) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3621360) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" CDS complement(3622414..3623859) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" gene complement(3622414..3623859) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" promotor_-10 complement(3623893..3623912) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3623903) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" promotor_-35 complement(3623926..3623933) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3624016..3624684) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" gene complement(3624016..3624684) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" downshifts complement(3624025) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" CDS complement(3624681..3625499) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" gene complement(3624681..3625499) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" CDS complement(3625507..3626412) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" gene complement(3625507..3626412) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" misc_feature complement(3626147..3626166) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3626158) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" promotor_-10 complement(3626453..3626472) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3626463..3626470 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3626474) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" upshifts 3626482 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" promotor_-10 3626484..3626503 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3626488..3626495) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3626518..3626904 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" gene 3626518..3626904 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" CDS 3626886..3627563 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" gene 3626886..3627563 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" downshifts 3627535 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" promotor_-35 3627607..3627614 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3627625 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" promotor_-10 3627628..3627647 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3627667..3628866 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" gene 3627667..3628866 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" CDS 3628900..3629097 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" gene 3628900..3629097 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" downshifts 3629076 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" CDS complement(3629133..3630323) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" gene complement(3629133..3630323) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" downshifts complement(3629148) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" downshifts complement(3629232) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" misc_feature complement(3630347..3630366) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3630363) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" promotor_-35 3630383..3630390 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3630399 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" promotor_-10 3630404..3630423 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3630444..3630824 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" gene 3630444..3630824 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" downshifts 3630722 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" downshifts 3630793 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" CDS complement(3630862..3631539) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391717.1" /db_xref="EnsemblGenomes-Gn:BSU38380" /db_xref="EnsemblGenomes-Tr:CAB15864" /db_xref="InterPro:IPR024250" /db_xref="SubtiList:BG10563" /db_xref="UniProtKB/Swiss-Prot:P39585" /translation="MLDYIWLDDESPILQQVPVEYSSAALIFSPFIQMPEGWENAKRK NDYEHIYPNDNEIRGIGKAVSWKKVMSSCGFQTHAELALALMTSIGALRDEFAREDLA EVLHENINGDLYYPSEDHISNFHIPSLVKVLGANGSNRFYYAEPIVENRGVLDITEAN LRTVLDEAATELVLTDEKMDFVFMSVYDSFINVFLAKDKNIHELVERMGWEAMICDES TYISWYR*" gene complement(3630862..3631539) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" downshifts complement(3630869) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3631548..3631567) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3631573) /Source="Nicolas_upshifts" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" promotor_-35 complement(3631579..3631585) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3631616..3632950) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8990303, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cellobiose phosphotransferase system enzyme IIC permease component" /protein_id="NP_391718.1" /db_xref="EnsemblGenomes-Gn:BSU38390" /db_xref="EnsemblGenomes-Tr:CAB15865" /db_xref="GOA:P39584" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG10562" /db_xref="UniProtKB/Swiss-Prot:P39584" /translation="MSTFTRVMEEKIMPVAGKIAGQRHLSALRDGIILTMPLIIIGSV FLILTSLPIPGYADFMASVFGNEWADKLGYPVNASFDIMAMIAAFGIAYRLAESYGVD ALSAGAISIAAFLLATPFEVPFTPHGSTESIMVGGGIPITLLGSKGLFVAMLIALFST EIYRYIIQKNIVFKMPDGVPPAVSKSFVALIPGFIIVLLVWLARLLIEMTPFQSLHNV VGDLLGTPLSILGGSLGGSLIAEFVQMLLWSCGIHGASIIGGIMAPIWYGAMDANRLA FQAGEALPSIFTTQFFQIWINVGGSGATLALVLTMLVRSRSKQMKQLGRLGIGPALFN INEPIIFGMPIVMNPLLIVPFIIAPLLTITATYIGMSTGLVARPAGIAVPWTMPPLIS GYLATGGKVSGAVMQLVNLLITCAIYYPFFRIWDHQKWREESAVESGDKNVM*" gene complement(3631616..3632950) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" misc_feature complement(3632998..3633016) /Source="Nicolas_upshift_promotors" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3633021) /Source="Nicolas_upshifts" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" promotor_-35 3633115..3633122 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3633127 /Source="Nicolas_upshifts" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" promotor_-10 3633136..3633154 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3633178..3635115 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391719.1" /db_xref="EnsemblGenomes-Gn:BSU38400" /db_xref="EnsemblGenomes-Tr:CAB15866" /db_xref="GOA:P16396" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10561" /db_xref="UniProtKB/Swiss-Prot:P16396" /translation="MKNMSCKLVVSVTLFFSFLTIGPLAHAQNSSEKEVIVVYKNKAG KETILDSDADVEQQYKHLPAVAVTADQETVKELKQDPDILYVENNVSFTAADSTDFKV LSDGTDTSDNFEQWNLEPIQVKQAWKAGLTGKNIKIAVIDSGISPHDDLSIAGGYSAV SYTSSYKDDNGHGTHVAGIIGAKHNGYGIDGIAPEAQIYAVKALDQNGSGDLQSLLQG IDWSIANRMDIVNMSLGTTSDSKILHDAVNKAYEQGVLLVAASGNDGNGKPVNYPAAY SSVVAVSATNEKNQLASFSTTGDEVEFSAPGTNITSTYLNQYYATGSGTSQATPHAAA MFALLKQRDPAETNVQLREEMRKNIVDLGTAGRDQQFGYGLIQYKAQATDSAYAAAEQ AVKKAEQTKAQIDINKARELISQLPNSDAKTALHKRLDKVQSYRNVKDAKDKVAKAEK YKTQQTVDTAQTAINKLPNGTDKKNLQKRLDQVKRYIASKQAKDKVAKAEKSKKKTDV DSAQSAIGKLPASSEKTSLQKRLNKVKSTNLKTAQQSVSAAEKKSTDANAAKAQSAVN QLQAGKDKTALQKRLDKVKKKVAAAEAKKVETAKAKVKKAEKDKTKKSKTSAQSAVNQ LKASNEKTKLQKRLNAVKPKK*" gene 3633178..3635115 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" promotor_-10 complement(3634322..3634341) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3634323) /Source="Nicolas_upshifts" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3634355..3634363) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3635105 /Source="Nicolas_upshifts" /id="D1990" /incds=0 /nref=175 /ntot=224 /MaxReadThrough="1.26567" /MaxDrop="6.00181" /score="15.6173594" /energy="-13" /TU="NA" /idTUdmin="U3021" /TUdmin=0 /isTUend="TRUE" promotor_-35 3635218..3635225 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3635240..3635259 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3635259 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3635471..3635478 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3635491..3635510 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3635491 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" CDS 3635543..3636922 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" gene 3635543..3636922 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" S_feature complement(3636631..3637834) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3636976..3637818 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" gene 3636976..3637818 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" CDS complement(3637869..3638729) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" gene complement(3637869..3638729) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" downshifts complement(3637879) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" downshifts 3638713 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" promotor_-10 complement(3638751..3638769) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3638769) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" promotor_-35 complement(3638784..3638790) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3638839..3639552) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" gene complement(3638839..3639552) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" promotor_-35 3638954..3638955 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3638975..3638992 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3638977 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3639580..3639591) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3639581) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3639606..3639612) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3639627..3639633 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3639648..3639667 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3639658 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" CDS 3639703..3640218 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" gene 3639703..3640218 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" misc_RNA 3640219..3640425 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" gene 3640219..3640425 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" downshifts 3640385 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" CDS 3640467..3641708 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" gene 3640467..3641708 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" promotor_-35 3641799..3641807 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3641818..3641836 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3641829 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" CDS 3641864..3643231 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" gene 3641864..3643231 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" downshifts 3643208 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" CDS complement(3643261..3643893) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" gene complement(3643261..3643893) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" downshifts complement(3643279) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(3643929..3643944) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3643937) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" promotor_-35 complement(3643957..3643965) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3644035..3644970) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" gene complement(3644035..3644970) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" downshifts complement(3644047) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" promotor_-35 3644714..3644723 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3644737..3644756 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3644741 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3644971..3645058) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3645041..3645060) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3645058) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" promotor_-35 complement(3645076..3645080) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3645103..3645115) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3645103) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" promotor_-35 complement(3645130..3645136) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3645133..3645267) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" gene complement(3645133..3645267) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" promotor_-35 3645214..3645221 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3645235..3645254 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3645244 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" S_feature 3645247..3645351 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3645346..3645355 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3645353 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" promotor_-10 3645367..3645382 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3645389) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(3645391..3645405) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3645417..3645566 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" gene 3645417..3645566 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" CDS 3645584..3647095 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" gene 3645584..3647095 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" CDS 3647092..3648279 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" gene 3647092..3648279 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" CDS 3648296..3648532 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" gene 3648296..3648532 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" CDS 3648532..3649710 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" gene 3648532..3649710 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" S_feature 3649711..3649800 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3649801..3650559 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" gene 3649801..3650559 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" downshifts 3650527 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" S_feature complement(3650561..3651788) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3650607..3650614 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3650628..3650647 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3650641 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" CDS 3650700..3651791 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" gene 3650700..3651791 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" downshifts 3651693 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" downshifts 3651781 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" CDS complement(3651825..3653153) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" gene complement(3651825..3653153) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" downshifts complement(3651833) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" CDS complement(3653150..3653482) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" gene complement(3653150..3653482) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" CDS complement(3653501..3654859) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" gene complement(3653501..3654859) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" CDS complement(3654875..3655183) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" gene complement(3654875..3655183) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" promotor_-10 complement(3655228..3655247) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3655244) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" promotor_-35 complement(3655261..3655267) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3655312) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" CDS complement(3655312..3657237) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" gene complement(3655312..3657237) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" promotor_-35 3655975..3655984 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3655998..3656017 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3656006 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3657310..3657327) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3657334) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" promotor_-35 complement(3657342..3657349) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3657400..3657558) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" gene complement(3657400..3657558) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" downshifts complement(3657427) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" CDS complement(3657587..3658177) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" gene complement(3657587..3658177) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" promotor_-10 complement(3658205..3658223) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3658216) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" promotor_-35 complement(3658237..3658243) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3658246..3658252 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3658268..3658286 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3658271 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" CDS 3658306..3659949 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" gene 3658306..3659949 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" S_feature complement(3658443..3659992) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3659944 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" S_feature complement(3659994..3660085) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3659996..3660002 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3660010 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3660017..3660036 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3660037) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" CDS 3660054..3661256 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" gene 3660054..3661256 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" S_feature complement(3660087..3661252) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3660130) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" CDS complement(3661253..3662029) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" gene complement(3661253..3662029) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" CDS complement(3662026..3662913) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" gene complement(3662026..3662913) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" CDS complement(3662920..3663108) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" gene complement(3662920..3663108) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" CDS complement(3663105..3663311) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" gene complement(3663105..3663311) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" CDS complement(3663308..3663628) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" gene complement(3663308..3663628) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" promotor_-35 3663441..3663450 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3663463..3663482 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3663465 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3663621..3664157) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" gene complement(3663621..3664157) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" upshifts complement(3664185) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" promotor_-10 complement(3664186..3664201) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3664213..3664222) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3664288..3664295 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3664309..3664328 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3664318 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" CDS 3664369..3665742 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" gene 3664369..3665742 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" S_feature complement(3664649..3665191) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3665179..3665198) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3665191) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3665213..3665220) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3665577 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" CDS complement(3665757..3666587) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" gene complement(3665757..3666587) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" downshifts complement(3665763) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" promotor_-10 complement(3666606..3666624) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3666621) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" promotor_-35 complement(3666639..3666645) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3666665) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(3666667..3666686) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3666673..3668400) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" gene complement(3666673..3668400) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" downshifts complement(3666772) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" CDS complement(3668397..3670100) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" gene complement(3668397..3670100) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" CDS complement(3670100..3671116) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" gene complement(3670100..3671116) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" promotor_-10 complement(3670990..3671008) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3670999) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" promotor_-35 complement(3671024..3671029) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3671100..3672506) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" gene complement(3671100..3672506) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" S_feature complement(3672507..3672715) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3672698..3672717) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3672715) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" S_feature complement(3672717..3672825) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3672731..3672736) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3672822..3672841) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3672837) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" promotor_-35 complement(3672855..3672862) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3672983..3672990 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3673000 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" promotor_-10 3673005..3673023 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3673062..3674414 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" gene 3673062..3674414 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" S_feature complement(3674013..3676495) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3674399 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" misc_feature 3674490..3674509 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3674496 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" CDS 3674536..3676224 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" gene 3674536..3676224 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" promotor_-35 3676222..3676231 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3676243..3676258 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3676247 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" CDS 3676282..3676482 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" gene 3676282..3676482 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" S_feature 3676483..3677427 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3676496..3677335) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" gene complement(3676496..3677335) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" promotor_-10 complement(3677361..3677379) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3677379) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" promotor_-35 complement(3677392..3677399) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3677394 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" CDS complement(3677442..3678539) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" gene complement(3677442..3678539) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" downshifts complement(3677443) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" promotor_-10 complement(3678572..3678591) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3678589) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" S_feature complement(3678591..3678659) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3678604..3678611) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3678660..3679553) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" gene complement(3678660..3679553) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" promotor_-10 complement(3679580..3679599) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3679599) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" promotor_-35 complement(3679613..3679620) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3679627..3679632 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3679648..3679666 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3679657 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3679674..3679680 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3679695..3679713 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3679701 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" CDS 3679737..3681194 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" gene 3679737..3681194 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" promotor_-10 complement(3680620..3680638) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3680635) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3680653..3680658) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3681175 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" downshifts 3681219 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" CDS complement(3681236..3682072) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" gene complement(3681236..3682072) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" downshifts complement(3681254) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" misc_RNA complement(3682149..3682251) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" gene complement(3682149..3682251) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" downshifts complement(3682175) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3682277..3682296) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3682288) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" S_feature complement(3682290..3683031) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3682310..3682316) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3682368..3682375 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3682388..3682406 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3682397 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" S_feature 3682407..3682492 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3682468..3682475 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3682489..3682508 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3682494 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" CDS 3682640..3683182 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" gene 3682640..3683182 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" promotor_-10 complement(3683007..3683026) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3683031) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" promotor_-35 complement(3683040..3683049) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3683172 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" S_feature 3683217..3683539 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3683257..3684276) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" gene complement(3683257..3684276) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" downshifts complement(3683275) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3684302..3684321) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3684316) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" promotor_-35 complement(3684336..3684339) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3684391..3684897) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" gene complement(3684391..3684897) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" promotor_-10 complement(3684903..3684922) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3684925) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" promotor_-35 3684927..3684930 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3684936..3684942) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3684945..3684964 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3684948 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" CDS 3685027..3685902 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" gene 3685027..3685902 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" S_feature complement(3685277..3685365) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3685299) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(3685325..3685425) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3685365) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" CDS 3685980..3686453 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" gene 3685980..3686453 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" CDS 3686471..3687691 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" gene 3686471..3687691 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" CDS 3687678..3688334 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" gene 3687678..3688334 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" promotor_-35 3688332..3688337 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3688351..3688370 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3688354 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" CDS 3688384..3689616 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" gene 3688384..3689616 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" downshifts complement(3688401) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" downshifts 3689601 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" promotor_-35 3689662..3689671 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3689684..3689699 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3689686..3689908 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3689686 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" downshifts 3689865 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" promotor_-35 3689919..3689925 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3689938..3690038 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3689938 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" promotor_-10 3689940..3689958 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3690017..3690024 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3690038..3690056 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3690040..3690137 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3690040 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" CDS 3690138..3690401 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" gene 3690138..3690401 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" promotor_-35 3690165..3690168 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3690183..3690202 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3690195 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" downshifts 3690349 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" downshifts 3690393 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" promotor_-35 3690468..3690477 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3690483 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" promotor_-10 3690489..3690504 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3690530..3691018 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" gene 3690530..3691018 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" promotor_-35 3691023..3691030 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3691044..3691063 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3691054 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" misc_RNA 3691084..3691190 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene 3691084..3691190 /gene="mswI" /locus_tag="BSU_misc_RNA_61" downshifts 3691185 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" CDS 3691273..3692406 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" gene 3691273..3692406 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" S_feature complement(3691546..3691789) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3691784..3691803) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3691793) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" promotor_-35 complement(3691818..3691825) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3692412..3692419 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3692434..3692453 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3692440 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" misc_RNA 3692475..3692581 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene 3692475..3692581 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" downshifts 3692528 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" S_feature 3692582..3692658 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3692659..3693795 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" gene 3692659..3693795 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" downshifts 3693782 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" CDS complement(3693848..3694621) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" gene complement(3693848..3694621) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" downshifts complement(3693858) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" CDS complement(3694638..3695288) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" gene complement(3694638..3695288) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" CDS complement(3695285..3696001) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" gene complement(3695285..3696001) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" CDS complement(3696025..3697443) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" gene complement(3696025..3697443) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" promotor_-10 complement(3696611..3696629) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3696630) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" promotor_-35 complement(3696645..3696650) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3697444..3697528) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3697512..3697530) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3697528) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" promotor_-35 complement(3697546..3697551) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3697597..3698445) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" gene complement(3697597..3698445) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" downshifts complement(3697607) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" S_feature complement(3698446..3698631) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3698620..3698639) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3698631) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" S_feature complement(3698633..3699358) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3698655..3698659) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3698793..3698800 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3698813..3698832 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3698822 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" misc_RNA 3698832..3698934 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" gene 3698832..3698934 /gene="gswB" /locus_tag="BSU_misc_RNA_63" S_feature 3698935..3699038 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3699010..3699016 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3699030..3699041 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3699040 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" CDS 3699061..3700254 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" gene 3699061..3700254 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" promotor_-10 complement(3699345..3699363) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3699361) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" promotor_-35 complement(3699376..3699383) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3700030 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" downshifts 3700250 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" CDS complement(3700296..3700724) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" gene complement(3700296..3700724) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo CDS complement(3700725..3700967) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" gene complement(3700725..3700967) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo S_feature complement(3700968..3701031) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3701020..3701035) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3701031) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" promotor_-35 complement(3701047..3701056) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3701064 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" CDS complement(3701112..3701402) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" gene complement(3701112..3701402) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" downshifts complement(3701118) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3701427..3701446) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3701444) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" CDS complement(3701452..3703512) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" gene complement(3701452..3703512) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" promotor_-35 complement(3701460..3701467) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3703541..3703559) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3703545) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" promotor_-35 complement(3703574..3703580) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3703605..3703610 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3703624 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" promotor_-10 3703626..3703644 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3703638..3703712 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3703713..3704993 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" gene 3703713..3704993 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" S_feature 3704994..3705133 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3705090 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" CDS complement(3705151..3705879) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" gene complement(3705151..3705879) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" downshifts complement(3705168) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(3705910..3705929) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3705921) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" promotor_-35 complement(3705943..3705950) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3706067..3706174) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3706110) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" CDS complement(3706175..3707008) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" gene complement(3706175..3707008) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" promotor_-10 complement(3707039..3707058) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3707058) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" promotor_-35 complement(3707072..3707079) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3707104..3707784) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" gene complement(3707104..3707784) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" promotor_-10 complement(3707831..3707850) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3707840) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" promotor_-35 complement(3707864..3707871) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3707932..3707935 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3707950..3707969 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3707950 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" CDS 3707991..3709277 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" gene 3707991..3709277 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" promotor_-10 complement(3708722..3708740) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3708730) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3708754..3708761) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3709248 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" CDS complement(3709296..3710735) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" gene complement(3709296..3710735) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" downshifts complement(3709319) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" misc_feature complement(3710759..3710778) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3710776) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" CDS complement(3710817..3711965) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" gene complement(3710817..3711965) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" promotor_-10 complement(3711992..3712008) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3712008) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" S_feature complement(3712010..3712094) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3712023..3712028) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3712095..3712283) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" gene complement(3712095..3712283) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo CDS complement(3712314..3712445) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " gene complement(3712314..3712445) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" CDS complement(3712457..3712918) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" gene complement(3712457..3712918) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" CDS complement(3712934..3713230) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" gene complement(3712934..3713230) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" CDS complement(3713258..3713746) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" gene complement(3713258..3713746) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" CDS complement(3713764..3714216) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" gene complement(3713764..3714216) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" S_feature complement(3714217..3714285) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3714286..3714615) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" gene complement(3714286..3714615) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" S_feature complement(3714616..3714737) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3714738..3715154) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" gene complement(3714738..3715154) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" CDS complement(3715205..3715573) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" gene complement(3715205..3715573) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" CDS complement(3715567..3716037) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" gene complement(3715567..3716037) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" S_feature complement(3716038..3716362) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3716363..3716791) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" gene complement(3716363..3716791) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" CDS complement(3716853..3723857) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" gene complement(3716853..3723857) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" misc_feature 3723864..3723878 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3723878 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3723888..3723907) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3723903) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" promotor_-35 complement(3723922..3723929) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3724019..3724954) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" gene complement(3724019..3724954) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" downshifts complement(3724240) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" S_feature complement(3724955..3725075) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3725106..3725552) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" gene complement(3725106..3725552) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" downshifts complement(3725120) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3725589..3725608) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3725596) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" promotor_-35 complement(3725622..3725629) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3725655..3727064) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" gene complement(3725655..3727064) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" CDS complement(3727087..3728916) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" gene complement(3727087..3728916) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" promotor_no_box complement(3728908..3729008) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3728948) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" S_feature complement(3728950..3729142) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3729123..3729142) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3729142) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" S_feature complement(3729144..3729277) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3729155..3729162) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3729299..3729607) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" gene complement(3729299..3729607) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" downshifts complement(3729322) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" CDS complement(3729653..3730096) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" gene complement(3729653..3730096) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" CDS complement(3730093..3731802) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" gene complement(3730093..3731802) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" misc_feature complement(3730964..3730983) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3730972) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" CDS complement(3731822..3732091) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" gene complement(3731822..3732091) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" CDS complement(3732103..3732468) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" gene complement(3732103..3732468) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" S_feature complement(3732469..3732534) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3732521..3732540) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3732534) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" promotor_-35 complement(3732555..3732558) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3732775..3734184) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" gene complement(3732775..3734184) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" downshifts complement(3732798) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" S_feature complement(3734185..3734294) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3734318..3734482) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" gene complement(3734318..3734482) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" promotor_-10 complement(3734367..3734385) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3734382) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3734396..3734404) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3734674..3734693) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3734690) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3734706..3734713) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3734722..3734729 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3734744..3734763 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3734747 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" CDS 3734801..3735247 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" gene 3734801..3735247 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" downshifts 3735252 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" CDS 3735360..3736886 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" gene 3735360..3736886 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" CDS 3736883..3738541 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" gene 3736883..3738541 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" CDS 3738554..3739819 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" gene 3738554..3739819 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" CDS 3739812..3740771 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" gene 3739812..3740771 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" S_feature 3740772..3740846 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3740847..3742274 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" gene 3740847..3742274 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" downshifts 3742270 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" CDS complement(3742318..3743619) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" gene complement(3742318..3743619) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" downshifts complement(3742335) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" CDS complement(3743649..3744830) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" gene complement(3743649..3744830) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" S_feature complement(3744831..3744910) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3744911..3745582) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" gene complement(3744911..3745582) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" promotor_-35 3745531..3745534 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3745549 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3745550..3745569 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3745610..3745629) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3745625) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" promotor_-35 complement(3745643..3745650) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3745688..3746629) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" gene complement(3745688..3746629) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" promotor_-10 complement(3746674..3746693) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3746680) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" S_feature complement(3746682..3746762) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3746709..3746712) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3746763..3747590) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391823.2" /db_xref="EnsemblGenomes-Gn:BSU39440" /db_xref="EnsemblGenomes-Tr:CAB15980" /db_xref="GOA:P39139" /db_xref="InterPro:IPR009597" /db_xref="SubtiList:BG10981" /db_xref="UniProtKB/Swiss-Prot:P39139" /translation="MAVKDRYMSKIKQETKPWIKRFGRLGYFAFGGVFILLGVLAFMT AAGAGRAKDSSGALQTLSRMPYGSLLLFFIGIGLIGYVIWMVLSAIKDTEGHGNSRRG LSRRIGNFFSAAVYTSIAWNALRFVFGQGDGGTSEQTWSAYVLAQPFGQWLTGLTGAG FIVFAIVQFMKGVRAAFMKEFDTSKMNKQMICITKNTGRAGNIARAIIFSAIGYFLIK TAMTADPDDTRGFDGALAELAQQPHGKLILSILALGLILYGMYAIMKGIYQHMTWEK* " gene complement(3746763..3747590) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" downshifts complement(3747562) /Source="Nicolas_upshifts" /id="D2045" /incds=0 /nref=6 /ntot=96 /MaxReadThrough="4.46865" /MaxDrop="3.48502" /score="14.6805498" /energy="-16" /TU="U3109,U3111" /idTUdmin="U3111" /TUdmin="-770" /isTUend="FALSE" promotor_-10 complement(3747615..3747633) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3747628) /Source="Nicolas_upshifts" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" promotor_-35 complement(3747647..3747653) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3747663..3748775) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1860825, 10746760, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ethanolamine permease" /protein_id="NP_391824.1" /db_xref="EnsemblGenomes-Gn:BSU39450" /db_xref="EnsemblGenomes-Tr:CAB15981" /db_xref="GOA:P54957" /db_xref="InterPro:IPR007441" /db_xref="SubtiList:BG11894" /db_xref="UniProtKB/Swiss-Prot:P54957" /translation="MTVNDAVVFILAAFLLWGAADYCLGNRWGLGERFADGFKAMGPL ALSMIGIVSLAPVLAAILIPIVAPFYTAIGADPSSFANTILAIDMGGYALAGEMAKDP QAGLFSWVFLGTMMGPAIVFTIPVALGIIEKEDHPYFAKGILIGLCTVPIGCLIGGLC AGFDIGMIGKNLLIPSLLSAVIAFGLWRYTDRMIQLFHLFGKAVSMVAIIGLAAVSVE TMTGIVLIPGMENVETGIQTTGTIAIALAGAFPMTAFITKTFKKPLQALGKCLHLDET ATAGLVTSLAHHIPMLASLKDMTPRGKVINVAFAVSGAFVLGSHLGFVAGMKKEMAAA MIIGKLAGGVTAAAAAAWMTPAQSAKQQKRISASHS*" gene complement(3747663..3748775) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" CDS complement(3748845..3750182) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic enzyme" /protein_id="NP_391825.2" /db_xref="EnsemblGenomes-Gn:BSU39460" /db_xref="EnsemblGenomes-Tr:CAB15982" /db_xref="GOA:P54956" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11893" /db_xref="UniProtKB/Swiss-Prot:P54956" /translation="MSKQGLTAGLAEAVRTSQPEHSVDAIHEAKKGLLDFTAASFAGR EDKGIQKLLRLIEDEGGRPLVPVIGQGKKAAPLQSAMLNGFIAHALDFDDVHSDVRGH PSAVIVPALIASAARGHDERLLGAYVVGVEVMARLGESIGSRHYEKGWHNTGTLGAIA AACAVGYAEELTQEELEKAIGFAATQSAGMRVQFGTEMKPLHAGLAAQAGLLAVKLAQ SEFGGSRTALDGETGFFSLYGDVEKAQHTLLNDWGAPWRIVQPGLWFKIYPFCSAAHH AADAVRQLISEETISAANTERIEVIFPPGGDAALTERSPKAGEEGRFSVEYVIALALH GHGLTVEHFSSQPIPNGVQTTMGRIQRVYDNAIQPAPHAVPKGRFTIVRAYLSDGRIC EARVDCPKGAPGNELSEEDIIEKLTLTVPQEKARRIITAVEKADIKEFLAHIE*" gene complement(3748845..3750182) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" CDS complement(3750179..3751321) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-sulfur-metabolite deacetylase" /protein_id="NP_391826.2" /db_xref="EnsemblGenomes-Gn:BSU39470" /db_xref="EnsemblGenomes-Tr:CAB15983" /db_xref="GOA:P54955" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="PDB:1YSJ" /db_xref="SubtiList:BG11892" /db_xref="UniProtKB/Swiss-Prot:P54955" /translation="MADKAFHTRLINMRRDLHEHPELSFQEVETTKKIRRWLEEEQIE ILDVPQLKTGVIAEIKGREDGPVIAIRADIDALPIQEQTNLPFASKVDGTMHACGHDF HTASIIGTAMLLNQRRAELKGTVRFIFQPAEEIAAGARKVLEAGVLNGVSAIFGMHNK PDLPVGTIGVKEGPLMASVDRFEIVIKGKGGHAGIPNNSIDPIAAAGQIISGLQSVVS RNISSLQNAVVSITRVQAGTSWNVIPDQAEMEGTVRTFQKEARQAVPEHMRRVAEGIA AGYGAQAEFKWFPYLPSVQNDGTFLNAASEAAARLGYQTVHAEQSPGGEDFALYQEKI PGFFVWMGTNGTEEWHHPAFTLDEEALTVASQYFAELAVIVLETIK*" gene complement(3750179..3751321) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" CDS complement(3751338..3752087) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391827.1" /db_xref="EnsemblGenomes-Gn:BSU39480" /db_xref="EnsemblGenomes-Tr:CAB15984" /db_xref="GOA:P54954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11891" /db_xref="UniProtKB/Swiss-Prot:P54954" /translation="MITVKNIRKAFKDLVVLDGIDLEVKRGEVVAIIGPSGSGKSTLL RCLNLLERPDQGLIEIGEAKLNAEKFTRKEAHRLRQQTAMVFQNYNLFKNKTALQNIT EALIVAQHKPRDEAKRIGMEILKQVGLEHKADSYPITMSGGQQQRIGIARALAVNPHA ILLDEPTSALDPELVTGVLQVIKSIAEKQTTMIIVTHEMAFAKEVADQVIFMADGHII EQGTPEELFDHPKNERTKRFIKQVGEPAELI*" gene complement(3751338..3752087) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" CDS complement(3752100..3752774) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 15849754, 16513748, 16850406, 16885442; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391828.1" /db_xref="EnsemblGenomes-Gn:BSU39490" /db_xref="EnsemblGenomes-Tr:CAB15985" /db_xref="GOA:P54953" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11890" /db_xref="UniProtKB/Swiss-Prot:P54953" /translation="MNTIDWEFMISAFPTLIQALPITLFMAIAAMIFAIIGGLILALI TKNKIPVLHQLSKLYISFFRGVPTLVQLFLIYYGLPQLFPEMSKMTALTAAIIGLSLK NAAYLAEIFRAALNSVDDGQLEACLSVGMTKFQAYRRIILPQAIRNAIPATGNTFIGL LKETSLAFTLGVMEMFAQGKMYASGNLKYFETYLAVAIVYWVLTIIYSILQDLFERAM SKPYRT*" gene complement(3752100..3752774) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" CDS complement(3752797..3753591) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_391829.1" /db_xref="EnsemblGenomes-Gn:BSU39500" /db_xref="EnsemblGenomes-Tr:CAB15986" /db_xref="GOA:P54952" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11889" /db_xref="UniProtKB/Swiss-Prot:P54952" /translation="MKMKKWTVLVVAALLAVLSACGNGNSSSKEDDNVLHVGATGQSY PFAYKENGKLTGFDVEVMEAVAKKIDMKLDWKLLEFSGLMGELQTGKLDTISNQVAVT DERKETYNFTKPYAYAGTQIVVKKDNTDIKSVDDLKGKTVAAVLGSNHAKNLESKDPD KKINIKTYETQEGTLKDVAYGRVDAYVNSRTVLIAQIKKTGLPLKLAGDPIVYEQVAF PFAKDDAHDKLRKKVNKALDELRKDGTLKKLSEKYFNEDITVEQKH*" gene complement(3752797..3753591) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" promotor_-35 3753163..3753172 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3753184 /Source="Nicolas_upshifts" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3753185..3753200 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3753616..3754113) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur-containing aminoacid acetyltransferase" /protein_id="NP_391830.2" /db_xref="EnsemblGenomes-Gn:BSU39510" /db_xref="EnsemblGenomes-Tr:CAB15987" /db_xref="GOA:P54951" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11888" /db_xref="UniProtKB/Swiss-Prot:P54951" /translation="MKPRYRLAVERDAEQLLELTLRAYEPIRKLGIRFAAAHADLDLV LKNIRENACYVMEEDGRIIATITLRMPWGKQPGPYGVPHIWWFAVDPDTGKKGIGTKL LQWLEETILRDTLKVPFVSLGTADKHPWLIEMYERKGYVRSGEQDLGKGHITVYMKKQ LRHDL*" gene complement(3753616..3754113) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" CDS complement(3754127..3755452) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8892809, 12193636, 15294834, 16513748, 16885442, 23944997; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391831.1" /db_xref="EnsemblGenomes-Gn:BSU39520" /db_xref="EnsemblGenomes-Tr:CAB15988" /db_xref="GOA:P54950" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG11887" /db_xref="UniProtKB/Swiss-Prot:P54950" /translation="MTSKKKQIKLGVFLAGTGHHVASWRHPDAPSDASMNLDYFKELA KTAERGKLDMLFLADSLSIDSKSHPNVLTRFEPFTLLSALAQVTSKIGLTATASTTYS EPFHIARQFASLDHLSNGRAGWNVVTSSIESTALNFSGEKHLEHHLRYQRAEEFVEIV KGLWDSWEEDAFIRNKETGEFFDKEKMHELNHKGEYFSVRGPLNVSRTPQGQPVIIQA GSSGDGKALAAKTAEVIFTAQNHLESAQEFYQSIKEQAAEFGRDPEKIAIMPGIFPII ADTEEAAQAKYKELQDLIIPSVGLQILQNYLGGIDLSAYPLDGPLPKLDAEASNAVKS RFKLVQEMAERDNMTIRELYKYVAGSRGHHIFVGTPEQLADKMQEWVDTKACDGFNIM PPLLPEGIEVFVDQVVPILQERGVFRKEYEGTTLREHFGLEKPVNRYAK*" gene complement(3754127..3755452) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" promotor_-10 complement(3755529..3755548) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3755533) /Source="Nicolas_upshifts" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" promotor_-35 complement(3755562..3755569) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3755638..3755865) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_391832.2" /db_xref="EnsemblGenomes-Gn:BSU39530" /db_xref="EnsemblGenomes-Tr:CAB15989" /db_xref="SubtiList:BG11886" /db_xref="UniProtKB/Swiss-Prot:P54949" /translation="MSLINSHQSADSGLNIWSQLFFYTIVTASEWIGGLQKRRKGKGN GEILYEIIGRKLSLCFIRLSFLADIEVALVE*" gene complement(3755638..3755865) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" CDS complement(3755852..3756838) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /EC_number="3.5.1.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15937167, 16511127, 18667582, 21978958" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937167, 16511127, 18667582, 21978958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin V amidase" /protein_id="NP_391833.2" /db_xref="EnsemblGenomes-Gn:BSU39540" /db_xref="EnsemblGenomes-Tr:CAB15990" /db_xref="GOA:P54948" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029132" /db_xref="PDB:2OQC" /db_xref="SubtiList:BG11885" /db_xref="UniProtKB/Swiss-Prot:P54948" /translation="MCTSLTLETADRKHVLARTMDFAFQLGTEVILYPRRYSWNSEAD GRAHQTQYAFIGMGRKLGNILFADGINESGLSCAALYFPGYAEYEKTIREDTVHIVPH EFVTWVLSVCQSLEDVKEKIRSLTIVEKKLDLLDTVLPLHWILSDRTGRNLTIEPRAD GLKVYDNQPGVMTNSPDFIWHVTNLQQYTGIRPKQLESKEMGGLALSAFGQGLGTVGL PGDYTPPSRFVRAVYLKEHLEPAADETKGVTAAFQILANMTIPKGAVITEEDEIHYTQ YTSVMCNETGNYYFHHYDNRQIQKVNLFHEDLDCLEPKVFSAKAEESIHELN*" gene complement(3755852..3756838) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" downshifts complement(3755856) /Source="Nicolas_upshifts" /id="D2046" /incds=0 /nref=7 /ntot=52 /MaxReadThrough="2.95669" /MaxDrop="3.32309" /score="23.0334771" /energy="-17.9" /TU="NA" /idTUdmin="U3113" /TUdmin=0 /isTUend="TRUE" promotor_-35 3755989..3755998 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3756012..3756031 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3756022..3756655 /Source="Nicolas_S_feature" /locus_tag="new_4062713_4063346" /HighExp="S6, S7, S8, S5, Paraq, G150, H2O2, G180, LBGexp, Oxctl" /AntisenseName="yxeI" /AntisenseCor="0.24221971906572701" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S1520" upshifts 3756022 /Source="Nicolas_upshifts" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" promotor_-10 complement(3756893..3756912) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3756904) /Source="Nicolas_upshifts" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" promotor_-35 complement(3756927..3756934) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3756993..3757805) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 21575135, 23582330, 25527541, 25848029, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sugar-phosphate hydrolase (promiscuous)" /protein_id="NP_391834.1" /db_xref="EnsemblGenomes-Gn:BSU39550" /db_xref="EnsemblGenomes-Tr:CAB15991" /db_xref="GOA:P54947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11884" /db_xref="UniProtKB/Swiss-Prot:P54947" /translation="MYKLIAIDMDGTLLNDHHEVTEEVRDALHAAKAEGVKIVLCTGR PIGGVQRYLDELNLIEEGDYVIAYNGALVQNTHTNEVVSELSLGYDDLTSLYDLSLEL KTPMHFFDSSNLYTPNRDISEFTVYESYVTQVPLHFRKIDEVPKDILIPKVMFIDKPE NLSRVITSIPKDVREKYTMVRSAPFFYEILHSEASKGNAVRQLAQLLGIEQAEVMCIG DNGNDLTMIEWAGCGVAMANAIPEVLEAANFQTRSNNEHGVAHAIHELVLAK*" gene complement(3756993..3757805) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" promotor_-10 complement(3757835..3757854) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3757845..3758402) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391835.1" /db_xref="EnsemblGenomes-Gn:BSU39560" /db_xref="EnsemblGenomes-Tr:CAB15992" /db_xref="GOA:P54946" /db_xref="SubtiList:BG11883" /db_xref="UniProtKB/Swiss-Prot:P54946" /translation="MRNQKAERLVAAGLVLHIIQWIFILWAFLKVKHLFSDYTIYNPN VISGSMQSLSFIQMMRAMMYSGAIVNYVLFFALVLLIYGIVLHAILIVLEMAAYVMIR RNPSSSWGFFFIAAGVKLAILNITGIPFLAAGFLLMKQKKAENGVKAERKRKPRLRIR RQGRRLNRIRRKPSLPVEYQKEKTI*" gene complement(3757845..3758402) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" upshifts complement(3757858) /Source="Nicolas_upshifts" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" promotor_-35 complement(3757869..3757876) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3758383..3758817) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /function="18: Unknown function" /experiment="publication(s) with functional evidences, PMID:11160890, 22693626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 22693626; Product type s: structure" /codon_start=1 /transl_table=11 /product="lipocalin-like lipoprotein" /protein_id="NP_391836.1" /db_xref="EnsemblGenomes-Gn:BSU39570" /db_xref="EnsemblGenomes-Tr:CAB15993" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR021664" /db_xref="PDB:2JOZ" /db_xref="SubtiList:BG11882" /db_xref="UniProtKB/Swiss-Prot:P54945" /translation="MVIPLRNKYGILFLIAVCIMVSGCQQQKEETPFYYGTWDEGRAP GPTDGVKSATVTFTEDEVVETEVMEGRGEVQLPFMAYKVISQSTDGSIEIQYLGPYYP LKSTLKRGENGTLIWEQNGQRKTMTRIESKTGREEKDEKSKS*" gene complement(3758383..3758817) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" promotor_-35 3758842..3758851 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3758861 /Source="Nicolas_upshifts" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" promotor_-10 3758864..3758883 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3758877) /Source="Nicolas_upshifts" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" S_feature complement(3758878..3759289) /Source="Nicolas_S_feature" /locus_tag="new_4065569_4065980_c" /HighExp="Salt, H2O2, Paraq, dia15, Oxctl, Diami, Cold, G150, Lbtran, LBGexp" /AntisenseName="yxeE" /AntisenseCor="-0.602938477548701" /AntisenseRegPval="-27.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.391, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1521" promotor_-10 complement(3758883..3758897) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3758906..3758910) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3758906..3759271 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 17905812, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 17905812, 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391837.1" /db_xref="EnsemblGenomes-Gn:BSU39580" /db_xref="EnsemblGenomes-Tr:CAB15994" /db_xref="SubtiList:BG11881" /db_xref="UniProtKB/Swiss-Prot:P54944" /translation="MNPYQYYSPQLPQQEPYYSHYEYNPYPQQDVYDPYQMDRQPALE RRIAALERQNEQQSRELTRLTNEDRRQNREIARIAEQVNQLSQAVERHTRRLNRLNQR LRTVENRLNIPFTAGEGGF*" gene 3758906..3759271 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" downshifts 3759285 /Source="Nicolas_upshifts" /id="D2047" /incds=0 /nref=31 /ntot=47 /MaxReadThrough="1.46494" /MaxDrop="8.36553" /score="27.2157513" /energy="-12.2" /TU="U3115" /idTUdmin="U3115" /TUdmin="-38" /isTUend="FALSE" promotor_-10 complement(3759289..3759293) /Source="Nicolas_upshift_promotors" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3759289) /Source="Nicolas_upshifts" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" S_feature complement(3759291..3759377) /Source="Nicolas_S_feature" /locus_tag="new_4065982_4066068_c" /HighExp="Salt, S8, H2O2, dia15, S7, Paraq, Diami, aero, Oxctl, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1522" promotor_-35 complement(3759314) /Source="Nicolas_upshift_promotors" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3759370..3759389) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3759377) /Source="Nicolas_upshifts" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" promotor_-35 complement(3759403..3759410) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3759450..3759456 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3759470..3759481 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3759477 /Source="Nicolas_upshifts" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" CDS 3759519..3759872 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26506528" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391838.2" /db_xref="EnsemblGenomes-Gn:BSU39590" /db_xref="EnsemblGenomes-Tr:CAB15995" /db_xref="SubtiList:BG11880" /db_xref="UniProtKB/Swiss-Prot:P54943" /translation="MHNTQHGLQQLNQCRQTAQQLIQQTQQSSQQYRQMLHQEQQNIQ MLQQILNHEQQAAHTIQQALHGHDMAIQKCQQVVNMCNQMQQELTGQSSVMNTNVSTL PFGQNTTFQQQSYQQ*" gene 3759519..3759872 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" downshifts 3759867 /Source="Nicolas_upshifts" /id="D2048" /incds=0 /nref=24 /ntot=55 /MaxReadThrough="0.20641" /MaxDrop="6.88486" /score="27.2157513" /energy="-12.2" /TU="NA" /idTUdmin="U3119" /TUdmin="-6" /isTUend="TRUE" CDS complement(3759916..3760314) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391839.2" /db_xref="EnsemblGenomes-Gn:BSU39600" /db_xref="EnsemblGenomes-Tr:CAB15996" /db_xref="GOA:P54942" /db_xref="SubtiList:BG11879" /db_xref="UniProtKB/Swiss-Prot:P54942" /translation="MGITKRGAAWEWLHSWWMLFIFMPFAITSFFAFLFIGIKVRNRK WIMYGIIYFFIFAFGFVLPDLPGVFIVVPLWAVTIIHGFKVRPLYLIQLDVYKDHVEA RAFAEARSEAESRFHAPKQSIQDIHIRKEQ*" gene complement(3759916..3760314) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" downshifts complement(3759924) /Source="Nicolas_upshifts" /id="D2049" /incds=0 /nref=145 /ntot=243 /MaxReadThrough="1.70512" /MaxDrop="5.26494" /score="9.81431167" /energy="-12.2" /TU="NA" /idTUdmin="U3120" /TUdmin=3 /isTUend="TRUE" promotor_-10 complement(3760329..3760348) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3760345) /Source="Nicolas_upshifts" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" promotor_-35 complement(3760363..3760366) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3760402..3760409 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3760418..3760436) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3760424..3760443 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3760433 /Source="Nicolas_upshifts" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" upshifts complement(3760433) /Source="Nicolas_upshifts" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3760452..3760457) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3760492..3761457 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 16672620, 8388528, 19254027, 23924612, 25007174; Product type t : transporter" /codon_start=1 /transl_table=11 /product="desferrioxamine-and ferrichrome-binding transporter lipoprotein (shuttle system)" /protein_id="NP_391840.2" /db_xref="EnsemblGenomes-Gn:BSU39610" /db_xref="EnsemblGenomes-Tr:CAB15997" /db_xref="GOA:P54941" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG11878" /db_xref="UniProtKB/Swiss-Prot:P54941" /translation="MKKNILLVGMLVLLLMFVSACSGTASKGSSSDSASEKTEMRTYK SPKGNVNIPAHPKRIVTDFYAGELLSVGANVVGSGSWSFDNPFLKSKLKNVKDVGDPI SVEKVMELQPDLIVVMNEENVDKLKKIAPTVVIPYNTAKNVEDTVSMFGDIAGAKDQA KSFMADFNKKAEAAKKKIAGVIDKDATFGIYENTDKGEFWVFNDNGGRGGQAVYNALG LKAPEKIEQDVIKKGEMKQLSQEVIPEYAADYMFITDYNPKGESKTLDKLENSSIWKN LDAVKHNRVFINDFDSFYPYDPISVSKQVDIITDMLIKRAEENKK*" gene 3760492..3761457 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" upshifts 3760885 /Source="Nicolas_upshifts" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3760892..3760910 /Source="Nicolas_upshift_promotors" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3761364 /Source="Nicolas_upshifts" /id="D2050" /incds=1 /nref=55 /ntot=191 /MaxReadThrough="6.103" /MaxDrop="4.3334" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=193 /isTUend="FALSE" downshifts 3761435 /Source="Nicolas_upshifts" /id="D2051" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="4.41732" /MaxDrop="3.7101" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=264 /isTUend="FALSE" S_feature 3761480..3762276 /Source="Nicolas_S_feature" /locus_tag="new_4068171_4068967" /HighExp="H2O2, Paraq, Lbexp, dia0, LBGexp, G150, B36, dia15, B60, GM 25" /AntisenseName="yxeA" /AntisenseCor="0.20524492145617201" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1523" CDS complement(3761498..3761845) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391841.1" /db_xref="EnsemblGenomes-Gn:BSU39620" /db_xref="EnsemblGenomes-Tr:CAB15998" /db_xref="InterPro:IPR006542" /db_xref="InterPro:IPR036166" /db_xref="PDB:3NPP" /db_xref="SubtiList:BG11877" /db_xref="UniProtKB/Swiss-Prot:P54940" /translation="MKKAMAILAVLAAAAVICGLLFFHNDVTDRFNPFIHQQDVYVQI DRDGRHLSPGGTEYTLDGYNASGKKEEVTFFAGKELRKNAYLKVKAKGKYVETWEEVK FEDMPDSVQSKLK*" gene complement(3761498..3761845) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" downshifts complement(3761511) /Source="Nicolas_upshifts" /id="D2052" /incds=0 /nref=2 /ntot=78 /MaxReadThrough="1.28842" /MaxDrop="2.99568" /score="38.5550476" /energy="-11.6" /TU="NA" /idTUdmin="U3120" /TUdmin="-1584" /isTUend="FALSE" CDS complement(3761859..3763727) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15849754, 15870467, 16850406, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15849754, 15870467, 16850406, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease); efflux of cationic peptides" /protein_id="NP_391842.2" /db_xref="EnsemblGenomes-Gn:BSU39630" /db_xref="EnsemblGenomes-Tr:CAB15999" /db_xref="GOA:P42424" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG11129" /db_xref="UniProtKB/Swiss-Prot:P42424" /translation="MTFLQFAYKNVTRNKRAYLAFFLSSAFSVLIFFTFAMFLFHPAL KEGYLNNIAKKGLTAAEWMIFVFSFLFVLYSVNAFLKSRNKEFGILLMQGITPGQLRK LITAENMIIGVMSIAAGIIGGFIFSKTFFTVGAYILEMDALPLYMPWKALGITACGFL LLFFFLSQFTILFVRSNTVIKLIKGTGKVKPEPKPSVLLSLFGIACLCGGYGMVLKGN VHGAEPFIILLLTVIGTYFFFSQSSIWILRALKKWKTFYLRGKNIIWVSDLVYRLKDN ARLFFIVSIISAVAFTATGVLAMYKSTVGAEESAYEMEYLSYSNNPKEQTHLKDIDHE LKTHGFTYTKDKIDVSYVRYQEGETVPPVYMISESDAAKYFHVKVNGLKEDEAVYFPG TYDRNFKNEAPDQLKLLNQKGELSDQKLSVKEVKKPLISLNAIIAVNDQTFDQLKSLG DKASLYGYSYDHWKDSLEISQSLQNEIYGNYIDVHSDFASKAGTYYDTVQLPSLSLFI GLFIAIVFFVAAASFLYFRLFTDLDEDRERYRSLAKIGLSEREMAQSVTIQLAILFFF PFVIAVMHTLFALRTLAVEGYSDVAGPLSLTIGGFFIFQLLFFLAVRSSYLKKMNK*" gene complement(3761859..3763727) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" CDS complement(3763702..3764475) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15870467, 17600057, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15870467, 17600057, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein); efflux ofcationic peptides" /protein_id="NP_391843.2" /db_xref="EnsemblGenomes-Gn:BSU39640" /db_xref="EnsemblGenomes-Tr:CAB16000" /db_xref="GOA:P42423" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11128" /db_xref="UniProtKB/Swiss-Prot:P42423" /translation="MANMLEVKHINKTYKGQVSYQALKQISFSIEEGEFTAVMGPSGS GKTTLLNIISTIDRPDSGDILINGENPHRLKRTKLAHFRRKQLGFVFQDFNLLDTLTI GENIMLPLTLEKEAPSVMEEKLHGIAAKLGIENLLNKRTFEVSGGQRQRAAIARAVIH KPSLILADEPTGNLDSKATKDVMETLQSLNRDDHVTALMVTHDPVSASYCRRVIFIKD GELFNEIYRGENRQVFYEQILDVLSMLGGNANDLSSVRL*" gene complement(3763702..3764475) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" CDS complement(3764619..3765596) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxdJ]" /protein_id="NP_391844.1" /db_xref="EnsemblGenomes-Gn:BSU39650" /db_xref="EnsemblGenomes-Tr:CAB16001" /db_xref="GOA:P42422" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11127" /db_xref="UniProtKB/Swiss-Prot:P42422" /translation="MKLFLRSHAVLILLFLLQGLFVFFYYWFAGLHSFSHLFYILGVQ LLILAGYLAYRWYKDRGVYHWLSSGQEGTDIPYLGSSVFCSELYEKQMELIRLQHQKL HETEAKLDARVTYMNQWVHQVKTPLSVINLIIQEEDEPVFEQIKKEVRQIEFGLETLL YSSRLDLFERDFKIEAVSLSELLQSVIQSYKRFFIQYRVYPKMNVCDDHQIYTDAKWL KFAIGQVVTNAVKYSAGKSDRLELNVFCDEDRTVLEVKDYGVGIPSQDIKRVFDPYYT GENGRRFQESTGIGLHLVKEITDKLNHTVDISSSPGEGTSVRFSFLTKM*" gene complement(3764619..3765596) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" CDS complement(3765593..3766282) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [TpeK(YxdK)]" /protein_id="NP_391845.1" /db_xref="EnsemblGenomes-Gn:BSU39660" /db_xref="EnsemblGenomes-Tr:CAB16002" /db_xref="GOA:P42421" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11126" /db_xref="UniProtKB/Swiss-Prot:P42421" /translation="MNKIMIVEDSEDIRGLLQNYLEKYGYQTVVAADFTAVLDVFLRE KPDVVLLDINLPAYDGYYWCRQIRQHSTSPIIFISARSGEMDQVMAIENGGDDYIEKP FSYDIVLAKIKSQIRRAYGEYAAKQGEKVVEYAGVQLFVERFELRFQDEKSELSKKES KLLEVLLERGEKVTSRDRLMEKTWDTDIFIDDNTLNVYITRLRKKLRELNAPVSIEAV RGEGYQLRAQS*" gene complement(3765593..3766282) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" promotor_-10 complement(3766309..3766328) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3766327) /Source="Nicolas_upshifts" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" promotor_-35 complement(3766343..3766349) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3766390..3767262) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /EC_number="4.1.2.29" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 10658656, 11325924, 18310071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 10658656, 11325924, 18310071; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid 6-phosphate aldolase" /protein_id="NP_391846.1" /db_xref="EnsemblGenomes-Gn:BSU39670" /db_xref="EnsemblGenomes-Tr:CAB16003" /db_xref="GOA:P42420" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11125" /db_xref="UniProtKB/Swiss-Prot:P42420" /translation="MAFVSMKELLEDAKREQYAIGQFNINGLQWTKAILQAAQKEQSP VIAAASDRLVDYLGGFKTIAAMVGALIEDMAITVPVVLHLDHGSSAERCRQAIDAGFS SVMIDGSHQPIDENIAMTKEVTDYAAKHGVSVEAEVGTVGGMEDGLVGGVRYADITEC ERIVKETNIDALAAALGSVHGKYQGEPNLGFKEMEAISRMTDIPLVLHGASGIPQDQI KKAITLGHAKININTECMVAWTDETRRMFQENSDLYEPRGYLTPGIEAVEETVRSKMR EFGSAGKAAKQQVG*" gene complement(3766390..3767262) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" downshifts complement(3766394) /Source="Nicolas_upshifts" /id="D2053" /incds=0 /nref=89 /ntot=172 /MaxReadThrough="3.05314" /MaxDrop="6.87265" /score="26.7325466" /energy="-8.2" /TU="NA" /idTUdmin="U3126" /TUdmin=0 /isTUend="TRUE" CDS complement(3767283..3768119) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /EC_number="5.3.99.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inosose isomerase" /protein_id="NP_391847.1" /db_xref="EnsemblGenomes-Gn:BSU39680" /db_xref="EnsemblGenomes-Tr:CAB16004" /db_xref="GOA:P42419" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="PDB:1I60" /db_xref="PDB:1I6N" /db_xref="SubtiList:BG11124" /db_xref="UniProtKB/Swiss-Prot:P42419" /translation="MKLCFNEATTLENSNLKLDLELCEKHGYDYIEIRTMDKLPEYLK DHSLDDLAEYFQTHHIKPLALNALVFFNNRDEKGHNEIITEFKGMMETCKTLGVKYVV AVPLVTEQKIVKEEIKKSSVDVLTELSDIAEPYGVKIALEFVGHPQCTVNTFEQAYEI VNTVNRDNVGLVLDSFHFHAMGSNIESLKQADGKKIFIYHIDDTEDFPIGFLTDEDRV WPGQGAIDLDAHLSALKEIGFSDVVSVELFRPEYYKLTAEEAIQTAKKTTVDVVSKYF SM*" gene complement(3767283..3768119) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" S_feature complement(3768120..3768204) /Source="Nicolas_S_feature" /locus_tag="new_4074811_4074895_c" /HighExp="M40t90, M0t90, BI, Sw, BC, T5.0H, T0.30H, T4.0H, T3.30H, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.101524" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1524" CDS complement(3768205..3769074) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9887260, 11566986, 12112707, 23874669; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_391848.1" /db_xref="EnsemblGenomes-Gn:BSU39690" /db_xref="EnsemblGenomes-Tr:CAB16005" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11123" /db_xref="UniProtKB/Swiss-Prot:P42418" /translation="MKLALDPSMYRDDLTLEEMVYKTAELGYEYIELSPREDFCPFYK YPKVDSAKIKQLKRLLRDTGVKLSSLLPLYHWAGPDEDRRQAAVRNWKRAIEIAVELE VDLMNSEFSGSKYDPLTSEEKFIKSMDELLPVFEKEGIKLNLQAHPYDFIETHKGAMD MIRALDKDWINLVYSTAHTFFYDDGKGDIETMFDEAGDRLTHVLFADTYNHKAAHGLR YIVNPPDAKVTVHQHLDIGQGEVDFDTIFRKLREMKFDGIATNAVFAWVDERADESSR FMLKKMKEELGLA*" gene complement(3768205..3769074) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" CDS complement(3769094..3770128) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /EC_number="1.1.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase" /protein_id="NP_391849.2" /db_xref="EnsemblGenomes-Gn:BSU39700" /db_xref="EnsemblGenomes-Tr:CAB16006" /db_xref="GOA:P26935" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR023794" /db_xref="InterPro:IPR036291" /db_xref="PDB:3MZ0" /db_xref="PDB:3NT2" /db_xref="PDB:3NT4" /db_xref="PDB:3NT5" /db_xref="PDB:3NTO" /db_xref="PDB:3NTQ" /db_xref="PDB:3NTR" /db_xref="PDB:4L8V" /db_xref="PDB:4L9R" /db_xref="SubtiList:BG10669" /db_xref="UniProtKB/Swiss-Prot:P26935" /translation="MSLRIGVIGTGAIGKEHINRITNKLSGAEIVAVTDVNQEAAQKV VEQYQLNATVYPNDDSLLADENVDAVLVTSWGPAHESSVLKAIKAQKYVFCEKPLATT AEGCMRIVEEEIKVGKRLVQVGFMRRYDSGYVQLKEALDNHVIGEPLMIHCAHRNPTV GDNYTTDMAVVDTLVHEIDVLHWLVNDDYESVQVIYPKKSKNALPHLKDPQIVVIETK GGIVINAEIYVNCKYGYDIQCEIVGEDGIIKLPEPSSISLRKEGRFSTDILMDWQRRF VAAYDVEIQDFIDSIQKKGEVSGPTAWDGYIAAVTTDACVKAQESGQKEKVELKEKPE FYQSFTTVQN*" gene complement(3769094..3770128) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" CDS complement(3770151..3771467) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="inositol transport protein" /protein_id="NP_391850.2" /db_xref="EnsemblGenomes-Gn:BSU39710" /db_xref="EnsemblGenomes-Tr:CAB16007" /db_xref="GOA:P42417" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11122" /db_xref="UniProtKB/Swiss-Prot:P42417" /translation="MGNTNGDSAFNKRTIAAALANYIDAGSIVAGSAGLSLWVSYLKL SDTQIGLLGALSANAISAAVGALLGGFLADKVGRKAVYTNSMLVYALGICLVLFGVNF PMLLSGYIIIGLSVGADITASWTIIAENAPKKNRARHCGVAQVAWAAGAVVVLLLSVL AGDLGLLGNKIVFAHLLVIALITYILRIRLPESDAWQTKNQPEEAQAEKPAVLNKTSY FDLLKPMYLKSILFLMGVYLVWNLAAGVMGFFMPYIYQQVGGVSANMANLLQMGLFIF TGLGVALIFMPFADKYRKTVFGIAAFMAVIGWTLFLLPVEGLPILLLFIVVIGINNGA GQQANYQLWASEIFPTQYRASAQGLMFFLVRISIGIWSLFVPMIITNFGIGTMAAILL GCVTASMIIGLLFAPNTSGKSLEQIQEELYGSPQSQVKKGTESKIM*" gene complement(3770151..3771467) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" CDS complement(3771482..3772375) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /EC_number="4.2.1.44" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 14993306, 22720735, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 14993306, 22720735, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inosose dehydratase" /protein_id="NP_391851.1" /db_xref="EnsemblGenomes-Gn:BSU39720" /db_xref="EnsemblGenomes-Tr:CAB16008" /db_xref="GOA:P42416" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR023952" /db_xref="InterPro:IPR030823" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11121" /db_xref="UniProtKB/Swiss-Prot:P42416" /translation="MGKNEILWGIAPIGWRNDDMPEIGAGNTLQHLLSDIVVARFQGT EVGGFFPEPAILNKELKLRNLRIAGKWFSSFILRDGLGEAAKTFTLHCEYLQQVNADV AVVSEQTYSVQSLEKNVFTEKPHFTDDEWERLCEGLNHLGEIAAQHGLKLVYHHHLGT GVQTAEEVDRLMAGTDPAHVHLLYDTGHAYISDGDYMGMLEKHIGRIKHVHFKDARLN VMEQCRLEGQSFRQSFLKGMFTVPGDGCIDFREVYQLLLKHSYSGWIVIEAEQDPDVA NPLEYALIARNYIDQQLLDLA*" gene complement(3771482..3772375) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" CDS complement(3772392..3774305) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /EC_number="3.7.1.22" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase" /protein_id="NP_391852.2" /db_xref="EnsemblGenomes-Gn:BSU39730" /db_xref="EnsemblGenomes-Tr:CAB16009" /db_xref="GOA:P42415" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR023757" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR030817" /db_xref="SubtiList:BG11120" /db_xref="UniProtKB/Swiss-Prot:P42415" /translation="MGKKIRLTTAQALIKFLNQQYIHVDGKEEPFVEGIFTIFGHGNV LGIGQALEQDAGHLKVYQGKNEQGMAHAAMAYSKQMLRRKIYAVSTSVGPGAANLVAA AGTALANNIPVLLIPADTFATRQPDPVLQQMEQEYSAAITTNDALKPVSRYWDRITRP EQLMSSLLRAFEVMTDPAKAGPATICISQDVEGEAYDFDESFFVKRVHYIDRMQPSER ELQGAAELIKSSKKPVILVGGGAKYSGARDELVAISEAYNIPLVETQAGKSTVEADFA NNLGGMGITGTLAANKAARQADLIIGIGTRYTDFATSSKTAFDFDKAKFLNINVSRMQ AYKLDAFQVVADAKVTLGKLHGLLEGYESEFGTTIRELKDEWLAERERLSKVTFKREA FDPEIKNHFSQEVLNEYADALNTELPQTTALLTINETIPEDSVIICSAGSLPGDLQRL WHSNVPNTYHLEYGYSCMGYEVSGTLGLKLAHPDREVYSIVGDGSFLMLHSELITAIQ YNKKINVLLFDNSGFGCINNLQMDHGSGSYYCEFRTDDNQILNVDYAKVAEGYGAKTY RANTVEELKAALEDAKKQDVSTLIEMKVLPKTMTDGYDSWWHVGVAEVSEQESVQKAY EAKEKKLESAKQY*" gene complement(3772392..3774305) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" CDS complement(3774338..3775315) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /EC_number="2.7.1.92" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid kinase" /protein_id="NP_391853.1" /db_xref="EnsemblGenomes-Gn:BSU39740" /db_xref="EnsemblGenomes-Tr:CAB16010" /db_xref="GOA:P42414" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR022841" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="InterPro:IPR030830" /db_xref="SubtiList:BG11119" /db_xref="UniProtKB/Swiss-Prot:P42414" /translation="MKYTFNEEKAFDIVAIGRACIDLNAVEYNRPMEETMTFSKYVGG SPANIAIGSAKLGLKAGFIGKIPDDQHGRFIESYMRKTGVDTTQMIVDQDGHKAGLAF TEILSPEECSILMYRDDVADLYLEPSEVSEDYIANAKMLLVSGTALAKSPSREAVLKA VQYAKKHQVKVVFELDYRPYTWQSSDETAVYYSLVAEQSDIVIGTRDEFDVMENRTGG SNEESVNHLFGHSADLVVIKHGVEGSYAYSKSGEVFRAQAYKTKVLKTFGAGDSYASA FIYGLVSGKDIETALKYGSASASIVVSKHSSSEAMPTAEEIEQLIEAQS*" gene complement(3774338..3775315) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" CDS complement(3775339..3776154) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /EC_number="5.3.1.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-deoxy-D-glucuronic acid isomerase" /protein_id="NP_391854.2" /db_xref="EnsemblGenomes-Gn:BSU39750" /db_xref="EnsemblGenomes-Tr:CAB16011" /db_xref="GOA:P42413" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR023770" /db_xref="InterPro:IPR024203" /db_xref="SubtiList:BG11118" /db_xref="UniProtKB/Swiss-Prot:P42413" /translation="MSYLLRKPQSHEVSNGVKLVHEVTTSNSDLTYVEFKVLDLASGS SYTEELKKQEICIVAVTGKITVTDHESTFENIGTRESVFERKPTDSVYISNDRAFEIT AVSDARVALCYSPSEKQLPTKLIKAEDNGIEHRGQFSNKRTVHNILPDSDPSANSLLV VEVYTDSGNWSSYPPHKHDQDNLPEESFLEETYYHELDPGQGFVFQRVYTDDRSIDET MTVGNENVVIVPAGYHPVGVPDGYTSYYLNVMAGPTRKWKFYNDPAHEWILER*" gene complement(3775339..3776154) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" S_feature complement(3776155..3776228) /Source="Nicolas_S_feature" /locus_tag="new_4082846_4082919_c" /HighExp="M40t90, M0t90, Lbtran, BI, Mt0, T0.30H, Sw, BC, S1, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1525" CDS complement(3776229..3777692) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /EC_number="1.2.1.27" /EC_number="1.2.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylmalonate-semialdehyde dehydrogenase" /protein_id="NP_391855.1" /db_xref="EnsemblGenomes-Gn:BSU39760" /db_xref="EnsemblGenomes-Tr:CAB16012" /db_xref="GOA:P42412" /db_xref="InterPro:IPR010061" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR023510" /db_xref="PDB:1T90" /db_xref="SubtiList:BG11117" /db_xref="UniProtKB/Swiss-Prot:P42412" /translation="MAEIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKE DIDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEAL GEVGRGIENVEFAAGAPSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPC WMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEH PEIKAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAA FGSAGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKR TLSYIEKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIR VKNLKEAIEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFS GWKSSFFGTLHANGKDSVDFYTRKKVVTARYPAPDFN*" gene complement(3776229..3777692) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" S_feature complement(3777693..3777897) /Source="Nicolas_S_feature" /locus_tag="new_4084384_4084588_c" /HighExp="M0t90, M40t90, Lbtran, BI, Mt0, T0.30H, BC, S1, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1526" promotor_-35 3777696..3777703 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-35" promotor_-10 3777719..3777738 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-10" upshifts 3777726 /Source="Nicolas_upshifts" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" S_feature 3777733..3778039 /Source="Nicolas_S_feature" /locus_tag="new_4084424_4084730" /HighExp="G180, Paraq, G150, Oxctl, H2O2, G135, Diami, LBGexp, dia5, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.788" /TUlongSig="NA" /TUlongPSig="NA" /label="S1527" promotor_-10 complement(3777879..3777898) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3777897) /Source="Nicolas_upshifts" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" S_feature complement(3777899..3778051) /Source="Nicolas_S_feature" /locus_tag="new_4084590_4084742_c" /HighExp="M40t90, M0t90, Lbtran, Diami, Heat, dia5, C30, BI, S1, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1528" promotor_-35 complement(3777913..3777920) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3777999..3778006 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-35" promotor_-10 3778021..3778040 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-10" upshifts 3778041 /Source="Nicolas_upshifts" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" promotor_-10 complement(3778052..3778071) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-10" upshifts complement(3778068) /Source="Nicolas_upshifts" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" promotor_-35 complement(3778087..3778094) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-35" CDS 3778108..3778863 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 11807058, 18310071, 24878601, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 11807058, 18310071, 24878601, 26735940; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the iol operon (DeoR family)" /protein_id="NP_391856.1" /db_xref="EnsemblGenomes-Gn:BSU39770" /db_xref="EnsemblGenomes-Tr:CAB16013" /db_xref="GOA:P46337" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11364" /db_xref="UniProtKB/Swiss-Prot:P46337" /translation="MKLMRIQEMEEYILSHGTVSLDELCQVFNVSKNTVRRDINKLTE KGAIEKVYGGVTSIEKTALVPFENRTIQHQDEKTKIAHYASRFIEDHDLVFIDSGTTT KSILDTLDPAKNVTILTNSLDIINAASALKNINLIIIGNNYKRKTRSFVGMDDPAMLD KYNINKAFMSATGTTLTHGLTNSDLLEYEIKKRISEKAKEVYLLADHSKFGKSTLLTY APFDRLHCIVTSQPLDDEYTQYCNEHQIGIHLA*" gene 3778108..3778863 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" promotor_-35 3778842..3778848 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3778863..3778882 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3778877 /Source="Nicolas_upshifts" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" CDS 3778917..3779849 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9226270, 15019785, 22720735, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_391857.1" /db_xref="EnsemblGenomes-Gn:BSU39780" /db_xref="EnsemblGenomes-Tr:CAB16014" /db_xref="GOA:P46336" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PYF" /db_xref="PDB:1PZ0" /db_xref="SubtiList:BG11363" /db_xref="UniProtKB/Swiss-Prot:P46336" /translation="MKKAKLGKSDLQVFPIGLGTNAVGGHNLYPNLNEETGKELVREA IRNGVTMLDTAYIYGIGRSEELIGEVLREFNREDVVIATKAAHRKQGNDFVFDNSPDF LKKSVDESLKRLNTDYIDLFYIHFPDEHTPKDEAVNALNEMKKAGKIRSIGVSNFSLE QLKEANKDGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTED TTFPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDIL IPGAKRADQLIDNIKTADVTLSQEDISFIDKLFA*" gene 3778917..3779849 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" downshifts 3779851 /Source="Nicolas_upshifts" /id="D2054" /incds=0 /nref=154 /ntot=259 /MaxReadThrough="4.521" /MaxDrop="7.17874" /score="39.70215" /energy="-17.1" /TU="U3129" /idTUdmin="U3127" /TUdmin=6 /isTUend="TRUE" promotor_-35 3779928..3779935 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3779949..3779968 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3779955..3780110 /Source="Nicolas_S_feature" /locus_tag="new_4086646_4086801" /HighExp="dia5, LPhT, Diami, Etha, dia15, LBGstat, M9-stat, Lbtran, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.835, 0.994" /TUlongSig="SigA" /TUlongPSig="0.99" /label="S1529" upshifts 3779955 /Source="Nicolas_upshifts" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" CDS 3780111..3780761 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391858.1" /db_xref="EnsemblGenomes-Gn:BSU39790" /db_xref="EnsemblGenomes-Tr:CAB16015" /db_xref="GOA:P46335" /db_xref="SubtiList:BG11362" /db_xref="UniProtKB/Swiss-Prot:P46335" /translation="MKLKYVKALVAVTVALGVLLPSTISHAKSFSGRSSSSYSSRSSS SSYSGSYKSSPKSSYSSGSSSSSKKSKTSDDSSSSISLKKKPSEKASSSSSKKSSGTF SGATSKVTGKTYSGKTSKAYVGGRYVSVNHYYHAGFAPSGWFGYYSGFTMGMFMISMM HPWGYTYHPVGGPGYVSYGASPIAWIVDIIALIIILIIVIALIRAFKAPKTYRRRF*" gene 3780111..3780761 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" CDS 3780765..3781073 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391859.1" /db_xref="EnsemblGenomes-Gn:BSU39800" /db_xref="EnsemblGenomes-Tr:CAB16016" /db_xref="InterPro:IPR020516" /db_xref="SubtiList:BG11361" /db_xref="UniProtKB/Swiss-Prot:P46334" /translation="MRLILNEQEIVDGICVYISNEEDIYPEDVEVKELSYNKRTGFFA EATFGLHHKQLMSDDISEGIIQFLEEYHNFNPDVTVVELQFDKKKGFSALVFVNEAEE *" gene 3780765..3781073 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" downshifts 3781075 /Source="Nicolas_upshifts" /id="D2055" /incds=0 /nref=185 /ntot=262 /MaxReadThrough="1.91541" /MaxDrop="6.4314" /score="14.1581732" /energy="-8.8" /TU="NA" /idTUdmin="U3130" /TUdmin="-2" /isTUend="TRUE" promotor_-35 3781217..3781223 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3781239..3781257 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3781249 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" CDS 3781311..3782696 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" gene 3781311..3782696 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" downshifts 3782682 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" S_feature 3782727..3783277 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3782738..3784618) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" gene complement(3782738..3784618) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" downshifts complement(3782744) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" S_feature complement(3784619..3784716) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3784707..3784726) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3784716) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" promotor_-35 complement(3784741..3784748) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3784786..3785037) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" gene complement(3784786..3785037) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" downshifts complement(3784804) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" misc_feature complement(3785059..3785078) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3785068) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" promotor_-35 3785101..3785107 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3785121..3785139 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3785122 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" CDS 3785154..3785975 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" gene 3785154..3785975 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" downshifts 3785959 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" CDS complement(3786004..3787146) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" gene complement(3786004..3787146) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" downshifts complement(3786014) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" S_feature complement(3787147..3787246) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3787234..3787253) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3787245) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" promotor_-35 complement(3787267..3787274) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3787289..3788626 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" gene 3787289..3788626 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" S_feature complement(3788031..3788631) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3788665..3789144) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " gene complement(3788665..3789144) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" downshifts complement(3788676) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" CDS complement(3789224..3790216) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" gene complement(3789224..3790216) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" downshifts complement(3789248) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" downshifts 3790206 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" promotor_-10 complement(3790239..3790258) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3790257) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" promotor_-35 complement(3790273..3790280) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3790279..3790286 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3790300..3790724 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3790300 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" promotor_-10 3790301..3790320 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3790306..3790718 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" gene 3790306..3790718 /gene="srlX" /locus_tag="BSU_misc_RNA_86" upshifts complement(3790326) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3790336..3790350) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3790358..3790362) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3790690 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" CDS 3790725..3791459 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" gene 3790725..3791459 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" CDS 3791459..3791728 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" gene 3791459..3791728 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" CDS 3791732..3792214 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" gene 3791732..3792214 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" CDS 3792235..3794478 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" gene 3792235..3794478 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" CDS 3794475..3795674 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" gene 3794475..3795674 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" promotor_-10 complement(3795430..3795448) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3795452) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3795463..3795469) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3795665 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" downshifts complement(3795738) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" CDS complement(3795738..3796970) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" gene complement(3795738..3796970) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" promotor_-10 complement(3797002..3797021) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3797014) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" promotor_-35 complement(3797035..3797040) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3797071..3797496) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" gene complement(3797071..3797496) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" promotor_-10 complement(3797524..3797543) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3797538) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" promotor_-35 complement(3797556..3797562) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3797688..3797695 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3797705 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" promotor_-10 3797710..3797729 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3797753..3798208 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" gene 3797753..3798208 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" downshifts 3798146 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" S_feature 3798209..3798822 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3798238..3799446) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" gene complement(3798238..3799446) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" downshifts complement(3798265) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" S_feature complement(3799447..3799553) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3799554..3800567) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" gene complement(3799554..3800567) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" S_feature complement(3800568..3800641) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3800626..3800645) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3800641) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" promotor_-35 complement(3800658..3800665) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3800661..3801236) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" gene complement(3800661..3801236) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" downshifts complement(3800685) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3801265..3801284) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3801279) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" promotor_-35 complement(3801299..3801306) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3801307..3801313 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3801328..3801346 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3801335 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" CDS 3801367..3802437 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" gene 3801367..3802437 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" downshifts 3802435 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" CDS complement(3802494..3802925) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" gene complement(3802494..3802925) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" promotor_-35 3802955..3802962 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3802976..3802995 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3802985..3803151 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3802985 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" promotor_-10 complement(3803037..3803056) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3803057) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" promotor_-35 complement(3803071..3803078) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3803152..3803556 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" gene 3803152..3803556 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" S_feature complement(3803173..3804225) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3803526..3804218 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" gene 3803526..3804218 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" CDS complement(3804258..3805289) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" gene complement(3804258..3805289) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" downshifts complement(3804270) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" promotor_-35 3805256..3805259 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3805272 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3805276..3805295 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3805326..3805344) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3805344) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" promotor_-35 complement(3805359..3805365) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3805382..3806530) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" gene complement(3805382..3806530) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" promotor_-10 complement(3806569..3806588) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3806580) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" promotor_-35 complement(3806599..3806606) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3806652..3806659 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3806673..3806692 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3806680 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" CDS 3806726..3807457 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" gene 3806726..3807457 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" CDS 3807450..3808991 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" gene 3807450..3808991 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" CDS 3809020..3810366 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" gene 3809020..3810366 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" promotor_-35 3809819..3809823 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3809839..3809858 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3809848 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" CDS 3810389..3811795 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" gene 3810389..3811795 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" downshifts 3811784 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" misc_feature 3811892..3811911 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3811894..3812185 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3811894 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" promotor_-35 3812158..3812165 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3812180..3812199 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3812187 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" promotor_-35 3812209..3812216 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3812231..3812250 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3812234) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3812237..3812251) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3812246 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" promotor_-35 complement(3812259..3812263) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3812259..3812822 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" gene 3812259..3812822 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" CDS 3812836..3814365 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" gene 3812836..3814365 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" downshifts complement(3814192) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" downshifts 3814358 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" S_feature complement(3814391..3814474) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3814434) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" CDS complement(3814475..3815914) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" gene complement(3814475..3815914) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" CDS complement(3815928..3816158) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" gene complement(3815928..3816158) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" S_feature complement(3816159..3816370) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3816367..3816386) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3816372) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" promotor_-35 complement(3816401..3816408) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3816434..3816441 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3816452..3816471 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3816467 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" CDS 3816502..3817212 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" gene 3816502..3817212 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" CDS 3817240..3817398 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" gene 3817240..3817398 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" downshifts 3817475 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" CDS complement(3817529..3818251) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" gene complement(3817529..3818251) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" downshifts complement(3817541) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" promotor_-35 3818152..3818155 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3818171..3818175 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3818186 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3818272..3818901) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" gene complement(3818272..3818901) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" S_feature complement(3818902..3819050) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3819051..3819809) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" gene complement(3819051..3819809) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" promotor_-10 complement(3819499..3819518) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3819515) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" promotor_-35 complement(3819531..3819538) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3819790..3820749) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" gene complement(3819790..3820749) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" downshifts 3820738 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" misc_feature 3820785..3820788 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3820793 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3820807..3820956) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" gene complement(3820807..3820956) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" downshifts complement(3820814) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" misc_feature 3820865..3820882 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3820870 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3820951 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" promotor_-10 complement(3820977..3820996) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3820998) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" promotor_-35 complement(3821011..3821018) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3821291..3821298 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3821313..3821332 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3821317 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" CDS 3821428..3823353 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" gene 3821428..3823353 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" S_feature 3823354..3824718 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" S_feature complement(3823566..3823886) /Source="Nicolas_S_feature" /locus_tag="new_4130257_4130577_c" /HighExp="Cold, C30, M/G, S8, Fru, nit, Glu, BMM, Heat, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1545" CDS complement(3823887..3825647) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative DNA wielding protein" /protein_id="NP_391900.1" /db_xref="EnsemblGenomes-Gn:BSU40200" /db_xref="EnsemblGenomes-Tr:CAB16057" /db_xref="InterPro:IPR018760" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11477" /db_xref="UniProtKB/Swiss-Prot:Q45598" /translation="MIVMIIKNLFVCNSQEILKEYKFNAVGVNIILGEKREDHEETNG VGKSTMIECISFLLGKTISNFYTTNEILLNKNVFIVLNVEIDGNQVFLARSFNSPKHG YTLHDTSLTFNLEEWKKVSISVYKKFIEKEILKGEKEDITFAALREYIIRDEKTGFND IVLPNRGGLKQYKLLNYLFTLPTHTEKNIKVFRDKIEKLNSEIKLIESMNINIGDLKV KEDELINEIEDYNRVIYQTKTANKYNNDTNRYSEIKSELNKIQNEIFENEHICKQYQR NIDDLNKKVTKIKELENIEKFYEDIVGFFPEEVKQNYNKVQEFYNFMVESRGSYFKDK IVKIQADLKKLNIKKQGLTEQLESSARILKSNNFIEDISIVMEEQRRKEIELAEVRLR ISDYDKKNHIFDKINELQHEILRVNSMYYDEFQSYSAIVSELKKLFNNLMDVTYNQHG FLDFEYDNRISNAKQSTTGRIKISCSIPDERSHGRLHMKINIFDLTWFLYRCINKCSL NILIHDGSYSNPDPHVKGTLLKHINSSLLENRIGQYFVTINKNELLLDDLQELESKGM IVAKLDRNNEDKNRFFGFRF*" gene complement(3823887..3825647) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" downshifts complement(3823930) /Source="Nicolas_upshifts" /id="D2081" /incds=0 /nref=11 /ntot=199 /MaxReadThrough="4.99391" /MaxDrop="4.47843" /score="7.49162587" /energy="-10.5" /TU="U3167" /idTUdmin="U3167" /TUdmin="-322" /isTUend="FALSE" misc_feature 3824715..3824716 /Source="Nicolas_upshift_promotors" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3824720 /Source="Nicolas_upshifts" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3825647..3826045) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391901.1" /db_xref="EnsemblGenomes-Gn:BSU40210" /db_xref="EnsemblGenomes-Tr:CAB16058" /db_xref="SubtiList:BG11476" /db_xref="UniProtKB/Swiss-Prot:Q45599" /translation="MIDLKIETAENILKYSYVLLENEFKNIQIGNDLIPLVNNSPLKK EKAERPEMNHFLLTKYNAVEENILYSSKILYELLEKEKHIDQLFLDYAKSQGIIINLN IERILYLSLTFLYSLGKVSFNQNMISRTES*" gene complement(3825647..3826045) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" CDS complement(3826038..3827483) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphohydrolase" /protein_id="NP_391902.1" /db_xref="EnsemblGenomes-Gn:BSU40220" /db_xref="EnsemblGenomes-Tr:CAB16059" /db_xref="GOA:Q45600" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11475" /db_xref="UniProtKB/Swiss-Prot:Q45600" /translation="MKVRFLQISDLHFQFQNYDTIVMRDKLLDFIEVLRRESDFDFLL LTGDIAHKGDVYNEDVKEYLNGIIKSMGLSKNNVHLVPGNHDISRDMTRTLLIDSIMK SPNPSEMLDKLDQKATNILVEGQRKFFDFYEDFMGVKYPEEDLHFLYQSEKYNVLSIN TCLLSDKKGEEGTLLTAQMKLYKAIRKMNKEKNKGKVLNIAIGHHTLGCIESSERESI KAHFDDYFIDLYLAGHVHDSSFNITANTNENPFLELVSGAIIKDEYATPEFISVDVNL DNGETEVTYYIWNTEYKYWSKNNQGGRRLQEGKLNYKINRLESLIEKEIEDNDDKIDE DEFKSFIIDFHEYRESYKTFTSNFDNQIGLDKKFYDMKSGETFKRKFDSYSEYFGVIN HIMDSTSYVSADKKELIAETIVDKYLEFHNQYNNGDEIFVKIVNEIYLECHSVLPYSK ALTKKYIKILTCWCIYECEIFNDNKRSVKND*" gene complement(3826038..3827483) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" promotor_-35 3826733..3826740 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3826752..3826771 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3826762..3827811 /Source="Nicolas_S_feature" /locus_tag="new_4133453_4134502" /HighExp="C30, Salt, Gly, S8, Etha, LPhT, T0.30H, Heat, C90, M9-stat" /AntisenseName="yydB" /AntisenseCor="0.36202116146901597" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.431" /TUlongSig="NA" /TUlongPSig="NA" /label="S1546" upshifts 3826762 /Source="Nicolas_upshifts" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" S_feature complement(3827484..3827744) /Source="Nicolas_S_feature" /locus_tag="new_4134175_4134435_c" /HighExp="Cold, M0t90, Lbtran, M40t90, Lbstat, T0.30H, MG 150, M40t45, Gly, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1547" CDS complement(3827745..3828224) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /EC_number="2.1.1.177" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18755835, 20817755, 22411911, 22720735, 28428565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (pseudouridine1915-N3)-methyltransferase" /protein_id="NP_391903.1" /db_xref="EnsemblGenomes-Gn:BSU40230" /db_xref="EnsemblGenomes-Tr:CAB16060" /db_xref="GOA:Q45601" /db_xref="InterPro:IPR003742" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1TO0" /db_xref="SubtiList:BG11474" /db_xref="UniProtKB/Swiss-Prot:Q45601" /translation="MNINIVTIGKLKEKYLKQGIEEYTKRLSAYAKIDIIELPDEKAP ENLSDQDMKIIKDKEGDRILSKISPDAHVIALAIEGKMKTSEELADTIDKLATYGKSK VTFVIGGSLGLSDTVMKRADEKLSFSKMTFPHQLMRLILVEQIYRAFRINRGEPYHK* " gene complement(3827745..3828224) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" S_feature complement(3828225..3828304) /Source="Nicolas_S_feature" /locus_tag="new_4134916_4134995_c" /HighExp="dia5, LBGtran, T0.30H, Diami, Cold, M0t90, dia0, M0t45, M40t45, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1548" CDS complement(3828305..3828475) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097800.1" /db_xref="EnsemblGenomes-Gn:BSU40239" /db_xref="EnsemblGenomes-Tr:CAX52715" /db_xref="InterPro:IPR025626" /db_xref="UniProtKB/Swiss-Prot:C0H3T9" /translation="MKQAYYSCEEHIETVLDMYIDDHELPPEIRKIEHTNSLSTACEL CGDPAVYIVGNE*" gene complement(3828305..3828475) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" promotor_-10 complement(3828516..3828535) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3828532) /Source="Nicolas_upshifts" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" promotor_-35 complement(3828549..3828554) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3828598..3828605 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3828618..3828637 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3828635 /Source="Nicolas_upshifts" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" CDS 3828660..3829073 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21911367; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391904.1" /db_xref="EnsemblGenomes-Gn:BSU40240" /db_xref="EnsemblGenomes-Tr:CAB16061" /db_xref="SubtiList:BG11472" /db_xref="UniProtKB/Swiss-Prot:Q45603" /translation="MRFRWVWLFVIMLLLAECQPSYWVLEKDRIGEGSPDLEIYANYL QMHDDVKGYQVFTISEGKKMVVVSLGSSEKDKKLEVSDVKFSSKETIVTVERKPAPTA NEKNPFILIGLDKIEGDLIVQDETGDRFEETDYQQ*" gene 3828660..3829073 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" downshifts 3829053 /Source="Nicolas_upshifts" /id="D2082" /incds=0 /nref=17 /ntot=131 /MaxReadThrough="1.50241" /MaxDrop="5.73792" /score="16.0382598" /energy="-10.8" /TU="NA" /idTUdmin="U3168" /TUdmin=0 /isTUend="TRUE" CDS complement(3829107..3830333) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18820069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_391905.1" /db_xref="EnsemblGenomes-Gn:BSU40250" /db_xref="EnsemblGenomes-Tr:CAB16062" /db_xref="GOA:Q45604" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014184" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11471" /db_xref="UniProtKB/Swiss-Prot:Q45604" /translation="MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVN RKCEHGVILKVITTNICGSDQHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGD IVSVPFNIACGRCVMCKTQKTHVCLNVNPDRPGSAYGYVDMGGWVGGQSEYVMVPYAD FQLLVFPDKEQALEKILDLTMLSDIFPTGFHGAYTAGVQTGSTVYIAGAGPVGLAAAH SAQLLGASTVIVGDLNEDRLAQARSFGCETVNVQKHDRLGEQIEQILGEPTVDAAVDC VGFEASGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIR FGLGWAKAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFD KGAAKKFVIDPHGTLK*" gene complement(3829107..3830333) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" downshifts complement(3829122) /Source="Nicolas_upshifts" /id="D2083" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="0.14321" /MaxDrop="4.77892" /score="8.82768619" /energy="-6.2" /TU="NA" /idTUdmin="U3169" /TUdmin=7 /isTUend="TRUE" promotor_-10 complement(3830356..3830374) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3830361) /Source="Nicolas_upshifts" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" promotor_-35 complement(3830386..3830394) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3830396..3830566) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097801.1" /db_xref="EnsemblGenomes-Gn:BSU40259" /db_xref="EnsemblGenomes-Tr:CAX52716" /db_xref="GOA:C0H3U0" /db_xref="UniProtKB/Swiss-Prot:C0H3U0" /translation="MQTNRVILLAVMICLVSAITVFLLNGCKVDFLDIGGTIIGCFLG IFVVVRIQKKQS*" gene complement(3830396..3830566) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" promotor_-10 complement(3830585..3830603) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3830603) /Source="Nicolas_upshifts" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" promotor_-35 complement(3830617..3830623) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3830671..3830919) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391906.1" /db_xref="EnsemblGenomes-Gn:BSU40260" /db_xref="EnsemblGenomes-Tr:CAB16063" /db_xref="GOA:Q45605" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG11470" /db_xref="UniProtKB/Swiss-Prot:Q45605" /translation="MGAIAVLFIVFGFPIVAGVFGIAGHFLFKRFWVAPLIVLITSLI LLVTLASGNSSFIFWVVMYTAIALVTSVATLFLRKFFE*" gene complement(3830671..3830919) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" CDS complement(3830935..3832098) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812, 16291680" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391907.2" /db_xref="EnsemblGenomes-Gn:BSU40270" /db_xref="EnsemblGenomes-Tr:CAB16064" /db_xref="InterPro:IPR011047" /db_xref="SubtiList:BG11469" /db_xref="UniProtKB/Swiss-Prot:Q45606" /translation="MKKWMITIAMLILAGIALFVFISPLKSHKTVSQQDLRNPDFLDD KEVLLYFSSSADQDAFGGGKSYALFISHDGTLSSFQMKGLELGSAKVHGDSVMLEDKN TIYTIKNGLRSHKRTYQHTGDSAGFLQNTDGFYTLYNSGYDKKGDGYRSELYRQMDGE WKKDVIPYYIRASGFHDGAIYALVPTDDGKGYQLLQIQADQKKLTYLSITEWQYREGA SVESQLAVDDQAVYVMVRGQKAHDLYQMVKINKKSGEVELHDIAEYKNDEQTIYSSMP FSFKNSFFPYDGNLYFIDGFGKVHKIDAKTGKTSIVFTLSPDKMKAEFKEITQKGSSL YFFTYTYHKPAYIEQYSLKTGKKMKEKEIGKVKDVVTPKSHLKLYDVEVMKRF*" gene complement(3830935..3832098) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" promotor_-10 complement(3830969..3830987) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3830977) /Source="Nicolas_upshifts" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" promotor_-35 complement(3830999..3831007) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3832109..3832846) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_391908.1" /db_xref="EnsemblGenomes-Gn:BSU40280" /db_xref="EnsemblGenomes-Tr:CAB16065" /db_xref="SubtiList:BG11468" /db_xref="UniProtKB/Swiss-Prot:Q45607" /translation="MKLKKRVSMFLVALTMCGGLFVTPAKAVKTTNYAEEIAALQPGT TPEEIMKSASQIAKQQHVKQDVILKQFYKEITADKAEGDRLAKESGMSIMGGSSGTKK LPTSAKGNIYYTNSYTAYYNHGHVGMYSAADKIVESVPSDGVRQIAYNARDVEDNSIV QTVSVSSSQKTAAADWAVSKVGDPYSFNFVNNRNTGHDGAKNCSKLLWSAFLLKAGID IDSNGGLGVYPRDITSSSYTTTIMTIY*" gene complement(3832109..3832846) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" promotor_-10 complement(3832888..3832906) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3832894) /Source="Nicolas_upshifts" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" promotor_-35 complement(3832920..3832928) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3832988..3833458) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14635137, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391909.1" /db_xref="EnsemblGenomes-Gn:BSU40290" /db_xref="EnsemblGenomes-Tr:CAB16066" /db_xref="GOA:O32293" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1ON0" /db_xref="PDB:1UFH" /db_xref="SubtiList:BG11467" /db_xref="UniProtKB/Swiss-Prot:O32293" /translation="MTIMLTPMQTEEFRSYLTYTTKHYAEEKVKAGTWLPEDAQLLSK QVFTDLLPRGLETPHHHLWSLKLNEKDIVGWLWIHAEPEHPQQEAFIYDFGLYEPYRG KGYAKQALAALDQAARSMGIRKLSLHVFAHNQTARKLYEQTGFQETDVVMSKKL*" gene complement(3832988..3833458) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" downshifts complement(3833001) /Source="Nicolas_upshifts" /id="D2084" /incds=0 /nref=1 /ntot=78 /MaxReadThrough="3.78599" /MaxDrop="2.94893" /score="8.04802973" /energy="-7.6" /TU="U3175" /idTUdmin="U3174" /TUdmin=0 /isTUend="TRUE" S_feature complement(3833459..3833529) /Source="Nicolas_S_feature" /locus_tag="new_4140150_4140220_c" /HighExp="S4, S5, S6, LoTm, S3, S7, S8, B36, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1549" promotor_-35 3833490..3833496 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3833510..3833529 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3833511..3833530) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3833511 /Source="Nicolas_upshifts" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" upshifts complement(3833529) /Source="Nicolas_upshifts" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" S_feature complement(3833531..3833806) /Source="Nicolas_S_feature" /locus_tag="new_4140222_4140497_c" /HighExp="S4, S5, S6, S7, S8, S3, B36, BT, LoTm, T5.0H" /AntisenseName="rapG" /AntisenseCor="-0.20647217228472101" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1550" promotor_-35 complement(3833545..3833552) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3833569..3834666 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391910.1" /db_xref="EnsemblGenomes-Gn:BSU40300" /db_xref="EnsemblGenomes-Tr:CAB16067" /db_xref="GOA:O32294" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11466" /db_xref="UniProtKB/Swiss-Prot:O32294" /translation="MNKIAPAEIASMLNDWYLAIKKHEVEESSRLFEEVKPLLDDMEE DQEVLAYFSLLELRHKVLLHEARGQGFQHEEPSHMNATSDMLKYYFFLFEGMYEAYKN NYDIAIGLYKDAEQYLDNIPDPIEKAEFHLKVGKLYYKLGQNIVSLNHTRQAVKTFRE ETDYKKKLASALITMSGNFTEMSQFEEAEAYLDEAIRITSELEDHFFEAQLLHNFGLL HAQSGKSEEAVSKLEEALQNDEYARSAYYYHSAYLLIRELFKIKKKEQALSYYQDVKE KLTAEPNRICEAKIDILYAIYAEGGHAETFHLCKQHMDDLLSEKEYDSVRELSILAGE RYRELELYKEAAHFFYEALQIEELIKRTEVI*" gene 3833569..3834666 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" promotor_-10 complement(3833797..3833815) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-10" upshifts complement(3833806) /Source="Nicolas_upshifts" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" promotor_-35 complement(3833830..3833835) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-35" promotor_-35 3834390..3834398 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3834410..3834428 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3834423 /Source="Nicolas_upshifts" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" CDS 3834667..3834783 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapG" /protein_id="NP_391911.1" /db_xref="EnsemblGenomes-Gn:BSU40310" /db_xref="EnsemblGenomes-Tr:CAB16068" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG11465" /db_xref="UniProtKB/Swiss-Prot:O32295" /translation="MKRFLIGAGVAAVILSGWFIADHQTHSQEMKVAEKMIG*" gene 3834667..3834783 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" downshifts 3834772 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" CDS complement(3835020..3835910) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" gene complement(3835020..3835910) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" downshifts complement(3835026) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" downshifts complement(3835088) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" CDS complement(3835984..3837387) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" gene complement(3835984..3837387) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" S_feature complement(3837388..3837609) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3837610..3838815) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" gene complement(3837610..3838815) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" misc_feature complement(3838872..3838890) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3838875) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" promotor_-35 3838985..3838990 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3839005..3839024 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3839020 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" CDS 3839056..3840441 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" gene 3839056..3840441 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" CDS complement(3840423..3840611) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" gene complement(3840423..3840611) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo CDS complement(3840728..3840856) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" gene complement(3840728..3840856) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" downshifts 3840780 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" CDS complement(3840876..3842078) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" gene complement(3840876..3842078) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" downshifts complement(3840900) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3842110..3842121) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3842110) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" promotor_-35 complement(3842136..3842142) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3842160..3842954) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" gene complement(3842160..3842954) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" CDS complement(3842976..3843818) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" gene complement(3842976..3843818) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" CDS complement(3843805..3845172) /gene="walH" /locus_tag="BSU_40390" /old_locus_tag="BSU40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYNNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" gene complement(3843805..3845172) /gene="walH" /locus_tag="BSU_40390" /old_locus_tag="BSU40390" CDS complement(3845162..3846997) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" gene complement(3845162..3846997) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" CDS complement(3847005..3847712) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" gene complement(3847005..3847712) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" S_feature complement(3847713..3847809) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3847797..3847816) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3847809) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" S_feature complement(3847811..3848003) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3847832..3847835) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3848003) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" misc_feature complement(3848013..3848032) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3848095) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" tRNA complement(3848096..3848168) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3848096..3848168) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" tRNA complement(3848204..3848280) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3848204..3848280) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" S_feature complement(3848281..3848361) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3848362..3848433) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3848362..3848433) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" tRNA complement(3848443..3848518) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3848443..3848518) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" misc_feature 3848490..3848506 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3848503 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3848519..3848615) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3848599..3848618) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3848615) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" promotor_-35 complement(3848632..3848639) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3848649..3848749) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3848689) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" CDS complement(3848742..3850034) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" gene complement(3848742..3850034) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" downshifts complement(3848753) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" promotor_-10 complement(3850074..3850093) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3850094) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" promotor_-35 complement(3850108..3850115) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3850240..3850659) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" gene complement(3850240..3850659) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" promotor_-10 complement(3850657..3850668) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3850668) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" promotor_-35 complement(3850683..3850689) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3850780..3852144) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" gene complement(3850780..3852144) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" downshifts complement(3850800) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" downshifts complement(3850844) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3852175..3852194) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3852189) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" promotor_-35 complement(3852209..3852211) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3852256..3852262 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3852277..3852295 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3852279 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" CDS 3852314..3852514 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" gene 3852314..3852514 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" downshifts 3852484 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" S_feature 3852529..3852850 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3852562..3852765) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" gene complement(3852562..3852765) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" S_feature complement(3852766..3853066) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3852831..3852834 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3852849..3852868 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3852852 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" CDS 3852886..3853026 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" gene 3852886..3853026 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" S_feature 3853027..3853098 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3853074) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" promotor_-10 complement(3853077..3853091) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3853099..3853103) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3853099..3854307 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" gene 3853099..3854307 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" downshifts 3854288 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" CDS 3854412..3856469 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" gene 3854412..3856469 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" downshifts 3856334 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" CDS complement(3856506..3856955) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" gene complement(3856506..3856955) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" downshifts complement(3856520) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" CDS complement(3856952..3858931) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" gene complement(3856952..3858931) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" misc_feature complement(3857433..3857452) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3857436) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" promotor_-35 3857849..3857856 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3857870..3857888 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3857874..3858540 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3857874 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" CDS complement(3858968..3859897) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" gene complement(3858968..3859897) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" S_feature complement(3859898..3860034) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3860016..3860035) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3860034) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" promotor_-35 complement(3860050..3860055) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3860124..3860273) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" gene complement(3860124..3860273) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" downshifts complement(3860150) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3860312..3860331) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3860329) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" promotor_-35 complement(3860345..3860351) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3860352..3860361 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3860374..3860393 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3860380 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" upshifts complement(3860392) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3860394..3860907) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3860396..3860410) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3860419..3860423) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3860419..3860901 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" gene 3860419..3860901 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" downshifts 3860888 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" CDS complement(3860931..3861308) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" gene complement(3860931..3861308) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" S_feature 3860933..3861462 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3860952) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" promotor_-10 complement(3861363..3861382) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3861375) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" promotor_-35 complement(3861396..3861403) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3861444..3861448 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3861462..3861481 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3861464 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" promotor_-10 complement(3861489..3861503) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3861492) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3861513..3862442 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" gene 3861513..3862442 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" promotor_-35 complement(3861517) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3862428 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" downshifts complement(3862471) /Source="Nicolas_upshifts" /id="D2102" /incds=0 /nref=14 /ntot=136 /MaxReadThrough="1.08899" /MaxDrop="4.94065" /score="19.3488922" /energy="-11.7" /TU="NA" /idTUdmin="U3200" /TUdmin=33 /isTUend="FALSE" CDS complement(3862475..3862921) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 25794618, 25794619; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative manganese-binding lipoprotein" /protein_id="NP_391936.1" /db_xref="EnsemblGenomes-Gn:BSU40560" /db_xref="EnsemblGenomes-Tr:CAB16093" /db_xref="GOA:P37488" /db_xref="SubtiList:BG10015" /db_xref="UniProtKB/Swiss-Prot:P37488" /translation="MKIILTVLAGVGLLSAGGCGMLDQVNDGLNYTSEAAGYVEKVKT FAEEAPELAEKAVNDTEAKEKLEAQLESIQKAAADFNELTPPDAAAEIHRTIQEHNET LQKSAEDVLKQAEEGKVSLKELEQSDLVQNAKQITDVMGQIEKLGE*" gene complement(3862475..3862921) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" S_feature complement(3862922..3863252) /Source="Nicolas_S_feature" /locus_tag="new_4169613_4169943_c" /HighExp="S8, Cold, S7, S6, H2O2, S5, S4, Etha, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998614" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1563" misc_RNA complement(3863111..3863228) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /product="manganese ion binding riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" gene complement(3863111..3863228) /gene="mswM" /locus_tag="BSU_misc_RNA_94" promotor_-10 complement(3863243..3863262) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3863251) /Source="Nicolas_upshifts" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" promotor_-35 complement(3863276..3863283) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3863289..3863295 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3863308 /Source="Nicolas_upshifts" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" promotor_-10 3863310..3863328 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3863324..3863330 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3863345..3863356 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3863352 /Source="Nicolas_upshifts" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" CDS 3863354..3864661 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391937.1" /db_xref="EnsemblGenomes-Gn:BSU40570" /db_xref="EnsemblGenomes-Tr:CAB16094" /db_xref="GOA:P37489" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10016" /db_xref="UniProtKB/Swiss-Prot:P37489" /translation="MTEEVFIMSQERVKRPGHTRWYISSLLSGIIILNYFDRVAISVA APAIQDSFHLTATELGIVFSIYTYSYTLMQLPVGSLLDRFGVAWVTRVGMTIWSFLTI LLAFLQGKLLLYLFRFLIGLTSASAFPAASKATALWFPPSERGLANSLFDSAAKFSNV IGAPLVAFLVTTFDWRVAFLTIGCINVLFTIFFWQYYEQPERHKRISKSELNYIQKHN AITTEQIPYKTGPLLKKLFTNRKVWGLMIGFTGYGYTFNLLLTWLPTFFKHTYGMDLM SSGLFTAVPWLISTISGIAVGGWLVDYFIKKGYPNTKVYRTVIIVGMSFGFFFLGSIL TNNITVAIICISIGLAGISATAPVGWSISAELAPIGSVSMLSSMVNLANNLFGGIIAA SLTGYLFDVTGSFTLSFLVAGFVLLLGLVFYVFVLGDVKRIKL*" gene 3863354..3864661 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" downshifts complement(3864462) /Source="Nicolas_upshifts" /id="D2103" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="0.73662" /MaxDrop="2.97868" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=264 /isTUend="FALSE" downshifts 3864650 /Source="Nicolas_upshifts" /id="D2104" /incds=0 /nref=7 /ntot=55 /MaxReadThrough="2.76545" /MaxDrop="3.99898" /score="-3.44083304" /energy="-17.9" /TU="NA" /idTUdmin="U3201" /TUdmin=0 /isTUend="TRUE" CDS complement(3864705..3864944) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52719.1" /translation="MNYKKQNQGFGSISGDHNDIHDILATIEENGTQDAFHYEGGLQG KNEQVLEQIEQEMLASGLDIEEQDEEKVNGDGPIL*" gene complement(3864705..3864944) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /pseudo downshifts complement(3864726) /Source="Nicolas_upshifts" /id="D2105" /incds=0 /nref=4 /ntot=114 /MaxReadThrough="3.05613" /MaxDrop="4.69729" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(3864730..3864830) /Source="Nicolas_upshift_promotors" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3864770) /Source="Nicolas_upshifts" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3864934..3865098) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52720.1" /translation="MMIRGIHLEQQLKDIISACDVAIQNEDFDTLMNYYSERIMCKPR KQPPQRFCEL*" gene complement(3864934..3865098) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /pseudo CDS complement(3865110..3865295) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514014.1" /translation="MSHQTKYPVNEAAIMPSNRLFARFTMELSMDTEPIGASSAEMDQ RNRKNKNEKDPYVSNIV*" gene complement(3865110..3865295) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" downshifts 3865376 /Source="Nicolas_upshifts" /id="D2106" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="0.18425" /MaxDrop="3.85413" /score="3.91893698" /energy="-13.7" /TU="NA" /idTUdmin="U3201" /TUdmin=726 /isTUend="FALSE" CDS complement(3865568..3865714) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52721.1" /translation="MYGKTIKKRLEKIAFLFQEISKKRKEKIERSFVGSKQLHGLSYR RFRG*" gene complement(3865568..3865714) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /pseudo CDS complement(3865696..3865845) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52722.1" /translation="MLNQHTLTYSTIDRKDYRSYKSNPEICLRILHKINETPESRYSV CMAKP*" gene complement(3865696..3865845) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /pseudo misc_feature complement(3866161..3866177) /Source="Nicolas_upshift_promotors" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3866178) /Source="Nicolas_upshifts" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3866197..3866204 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3866219..3866422 /Source="Nicolas_S_feature" /locus_tag="new_4172910_4173113" /HighExp="nit, T-3.40H, T-1.40H, T-0.40H, T0.0H, SMMPr, SMM, LoTm, ferm, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1564" promotor_-10 3866219..3866238 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3866219 /Source="Nicolas_upshifts" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" misc_feature complement(3866240..3866254) /Source="Nicolas_upshift_promotors" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3866244) /Source="Nicolas_upshifts" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" CDS 3866423..3866860 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27902860" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391938.1" /db_xref="EnsemblGenomes-Gn:BSU40580" /db_xref="EnsemblGenomes-Tr:CAB16095" /db_xref="InterPro:IPR020208" /db_xref="SubtiList:BG10017" /db_xref="UniProtKB/Swiss-Prot:P37490" /translation="MNKFLKSNFRFLLAAALGISLLASSNFIKASNDNYKFHLLVPYG YGNAYSNDAFRQTTHTDNPWKVNLQKSAEGKGTIMTFWLINTGNSKIPKASKIHNVKQ GSGAHYYHANSQGSHTYVALAVENNNYSASSYGIDGVWDEETW*" gene 3866423..3866860 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" S_feature 3866861..3866937 /Source="Nicolas_S_feature" /locus_tag="new_4173552_4173628" /HighExp="M9-tran, SMMPr, MG 120, aero, GM 120, SMM, T-2.40H, T-4.40H, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1565" downshifts 3866894 /Source="Nicolas_upshifts" /id="D2107" /incds=0 /nref=10 /ntot=98 /MaxReadThrough="6.91942" /MaxDrop="3.8662" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3201" /TUdmin=2244 /isTUend="FALSE" CDS 3866974..3867729 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391939.1" /db_xref="EnsemblGenomes-Gn:BSU40590" /db_xref="EnsemblGenomes-Tr:CAB16096" /db_xref="SubtiList:BG10018" /db_xref="UniProtKB/Swiss-Prot:P37491" /translation="MESHIYRIIKNKLTIIIFTIIILIPCVDISLLLMTNTEYHPAYA FFLSGTSVGHASQMILLWFLPLYFLLLCADDSIQDYKTGYHYILISKVGRKKYCLEKI FTSFIISFLTMFLSLILNFLLVQVFFFKGTFKNDLDQIKFPDNSLYTFSMAHPYIAIV LFSIICCIMSGFVGALGSSLSLLFRDKKYAYPASFFIWFVLILKNKSLMFLFQPFTEY GYNVLLPILCLSIFIFLIIISSIVLYEAKYNEN*" gene 3866974..3867729 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" S_feature complement(3867569..3870159) /Source="Nicolas_S_feature" /locus_tag="new_4174260_4176850_c" /HighExp="S8, S6, S4, S5, S7, S3, C30, BT, G135, T5.0H" /AntisenseName="yybK" /AntisenseCor="-0.46686696237140402" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1566" CDS 3867719..3868429 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391940.1" /db_xref="EnsemblGenomes-Gn:BSU40600" /db_xref="EnsemblGenomes-Tr:CAB16097" /db_xref="SubtiList:BG10019" /db_xref="UniProtKB/Swiss-Prot:P37492" /translation="MKIKRLLLILCLLLFLVTLWFNQNHTYLGKNSIASLLYMNNSTF GYSSIFAYTLFYIVPFLMLLSNFFHSENPYKVMRMVKRKNYYKSKIMEIGFVSLLFSS IHTVINITCTHIFFSKNLLVEANFLSICLLNMISLVFFYLSVGIMFRLTYDLFNSVAL AIFIVYIILDSLYFGVKLLLPNGYWEPFRDLAIFTNMLNRYWSTSNLIIVYIRQIIIV FIFYLVGSSIFLNKDYKK*" gene 3867719..3868429 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" downshifts 3867928 /Source="Nicolas_upshifts" /id="D2108" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="7.39982" /MaxDrop="2.95139" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3205" /TUdmin="-2354" /isTUend="FALSE" CDS 3868426..3869181 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391941.1" /db_xref="EnsemblGenomes-Gn:BSU40610" /db_xref="EnsemblGenomes-Tr:CAB16098" /db_xref="InterPro:IPR024295" /db_xref="SubtiList:BG10020" /db_xref="UniProtKB/Swiss-Prot:P37493" /translation="MRIKGFFITLVAIIFQASLSSYNNNKNVFPFLDGIPISTSGHYE YQNILLWFVPIVSLSFCFSGSIRDTYISYEQLKLVREHSRVKWVTSQFLIITVVLLIF TLSQIAIFYIYSLVSLHNLDINSVINKRFVMMTLMYYLTLLNLFSFQLFMELYYKSQI AQLNISVYIIFSLILAKKLVQLNSPKVIHYFLIPNYSNGLRTGLSYYSQSGTAIIEPL LGLFIIIILQISIVILSVLKFKKIDMLKSEGLQ*" gene 3868426..3869181 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" CDS 3869178..3869834 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1938973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-binding cassette subunit of transporter" /protein_id="NP_391942.1" /db_xref="EnsemblGenomes-Gn:BSU40620" /db_xref="EnsemblGenomes-Tr:CAB16099" /db_xref="GOA:P37494" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10021" /db_xref="UniProtKB/Swiss-Prot:P37494" /translation="MIEVLNLTKKIKKTTVLDNISYTFEKGTIYGLFGSNGSGKTMLL RALSGLIVPTEGSITIKGEQLHKDISFPKSVGLIIENMQLLPQYDAFTNLKILSKIKK IASDNDILDSISRVGLENFNSVKVSKFSLGMKQRLNIAQAIFEKPDILLLDEPTNAID EKGVAFVHDILLQEKKRGATIIITSHHKEDIISLCDIALEMNHGRLETSEKVIYKKDS *" gene 3869178..3869834 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" S_feature 3869835..3870149 /Source="Nicolas_S_feature" /locus_tag="new_4176526_4176840" /HighExp="aero, Cold, HPh, nit, M/G, M9-tran, S1, SMM, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1567" downshifts 3870106 /Source="Nicolas_upshifts" /id="D2109" /incds=0 /nref=93 /ntot=227 /MaxReadThrough="3.45614" /MaxDrop="4.54398" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-176" /isTUend="FALSE" downshifts 3870150 /Source="Nicolas_upshifts" /id="D2110" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.98662" /MaxDrop="3.29879" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-132" /isTUend="FALSE" downshifts complement(3870204) /Source="Nicolas_upshifts" /id="D2111" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.53364" /MaxDrop="2.25148" /score="10.1219981" /energy="-6.3" /TU="U3207" /idTUdmin="U3209" /TUdmin=2266 /isTUend="FALSE" CDS complement(3870209..3870997) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16321932, 22882546, 25835496" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932, 22882546, 25835496; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391943.1" /db_xref="EnsemblGenomes-Gn:BSU40630" /db_xref="EnsemblGenomes-Tr:CAB16100" /db_xref="SubtiList:BG10022" /db_xref="UniProtKB/Swiss-Prot:P37495" /translation="MNVYDIRMAPYWFYEGRGLVQHPYVFRQPVSSRAIIVSTRGDVT GDGVIDEVFLTGNQMPGSPLWRNITLVIRDGRTHQEQRIQLQNNMGYNPSLFLGDMTG DKIEDVAVVMDTGGSGGAIYAYVFAYLNRQFRRIFNSDVLNDELKYSVRYQNQYKASV ISHQQNETYILDLTYKGREYLNEIYNSQGVLKMPIEGWVNPLSGLYPVDFDRDGVYEL LAYQRIAGRYNADSLGYVQTVLKWNGQRFMFNRQTVTIFGSDLS*" gene complement(3870209..3870997) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" promotor_-10 complement(3871021..3871039) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3871040) /Source="Nicolas_upshifts" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" promotor_-35 complement(3871055..3871060) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3871065..3871454) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391944.1" /db_xref="EnsemblGenomes-Gn:BSU40640" /db_xref="EnsemblGenomes-Tr:CAB16101" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:2GXF" /db_xref="SubtiList:BG10023" /db_xref="UniProtKB/Swiss-Prot:P37496" /translation="MEQQLKDIISACDLAIQNEDFDTLMNYYSEDAVLVVKPGMIARG KEEIKKAFITIANYFNHHIVPTQGKMILLEAGDTVLVLSQTLLDSDKKDSEYAMERRA TYVFKKNAQGEWLCVIDNSYGTDLIGV*" gene complement(3871065..3871454) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" promotor_-35 3871523..3871526 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3871541..3871560 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3871554 /Source="Nicolas_upshifts" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" CDS 3871600..3872439 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11709313, 12486061" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391945.1" /db_xref="EnsemblGenomes-Gn:BSU40650" /db_xref="EnsemblGenomes-Tr:CAB16102" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG10024" /db_xref="UniProtKB/Swiss-Prot:P37497" /translation="MSAEVTLHDNIHYDLSADCQHCFGLCCVALPYAKSADFAFDKDG GTPCRNLQSNYQCSIHKDLREKGFRGCSAYECFGAGQKVSQITYEGKDWRNSPETANQ MFDVFPIMQQLHEMLWYLHEALSIDIAKPIHSELRTTFEKIERLTRLSKERLLTLQVD EHRAEVNEWLLKTSELVRAQARHPKLPKKVSRGSVLIGAKLKGLDLRGANLRGALLIA ADLRNADLRMTDFIGADMRDADLSGADLTGSIFLTQAQVNAANGDSNTKLPLSVRTPA HWK*" gene 3871600..3872439 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" downshifts 3872416 /Source="Nicolas_upshifts" /id="D2112" /incds=0 /nref=35 /ntot=188 /MaxReadThrough="1.19247" /MaxDrop="3.72166" /score="-0.156630814" /energy="-6.3" /TU="NA" /idTUdmin="U3208" /TUdmin=0 /isTUend="TRUE" CDS complement(3872472..3873686) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811656, 11557812, 12486061, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391946.1" /db_xref="EnsemblGenomes-Gn:BSU40660" /db_xref="EnsemblGenomes-Tr:CAB16103" /db_xref="GOA:P37498" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10025" /db_xref="UniProtKB/Swiss-Prot:P37498" /translation="MTYIRKGTPVFRKITFAFFAAGFNTFAILYCVQPLMEEFTREFH VTPTAASLSLSVTTMLLAVSMLVFGSLSEVWGRKPIMGISMLAASVLCLASAFSPSFH TLLVLRTIQGVALAGLPSIAMAYLGEEIEPGSLGSAMGLYISGNAIGAVFGRIVSGLL SEYLNWHMAMGTIGVISLIASVIFFINLPPSRHFTPRKLKLGKLGMSLIGHLRDRKLF SLFLIGFLLLGSNVALFNYIVYVLLGPPYSLNKAFSSWIFIVMIVGIFSSSFIGRMVD RYGYPKILVMNIFIVIAGALFTINNMLAVKILGIALFTFGFFGGHSVASSWVGRRALH NKAQASSLYLFFYYAGSSVFGTIGGLFWSGFHWLGVVGMITFMLLVALWLSGYLARSV KMPDKRNEKGLN*" gene complement(3872472..3873686) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" downshifts complement(3872490) /Source="Nicolas_upshifts" /id="D2113" /incds=0 /nref=45 /ntot=169 /MaxReadThrough="1.92237" /MaxDrop="5.70619" /score="10.1219981" /energy="-6.3" /TU="NA" /idTUdmin="U3209" /TUdmin="-20" /isTUend="TRUE" S_feature complement(3873687..3873790) /Source="Nicolas_S_feature" /locus_tag="new_4180378_4180481_c" /HighExp="BI, B60, ferm, T0.30H, T-1.10H, T-0.40H, T-1.40H, T1.0H, nit, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94819299999999995" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1568" promotor_-10 complement(3873783..3873802) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3873791..3873798 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3873793) /Source="Nicolas_upshifts" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" promotor_-10 3873812..3873831 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3873816..3873823) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3873824 /Source="Nicolas_upshifts" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" CDS 3873873..3874751 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591, 17526699, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391947.2" /db_xref="EnsemblGenomes-Gn:BSU40670" /db_xref="EnsemblGenomes-Tr:CAB16104" /db_xref="GOA:P37499" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10026" /db_xref="UniProtKB/Swiss-Prot:P37499" /translation="MEWEQLEYFQTLARMQHVTKAAKSLSITQPALSRSIARLENHLG VPLFDRQGRSISLNQYGHIFLRRVQAMMKEYTEGKEEIQALLKPDQGVVSLGFLHTLG TTLVPDLIGSFQQEYPNISFQLKQNHSYWLLERLKSGDLDLCLLASIKPENPIQWIKL WSEELFVFVPNDHPLASRESITLNEIAGERFILLKKGYALRMTVDELFEKANIQPNIM FEGEEATTAAGFVAAGLGISILPDLKGLDQSKITKIRVSWPECQRVIGIAWIKGRFLS PVAETFKQYVISHFSE*" gene 3873873..3874751 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" CDS 3874765..3875208 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_391948.1" /db_xref="EnsemblGenomes-Gn:BSU40680" /db_xref="EnsemblGenomes-Tr:CAB16105" /db_xref="GOA:P37500" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10027" /db_xref="UniProtKB/Swiss-Prot:P37500" /translation="MNVKKITSEQDLHTAFEIRKAVFVEEQGCPISDEFDEFDTLHGD CQHILAYHQNVPVGTARVRIVGHTGKLERICILKSYRKFGLGKVIVDALERIVKEQGI SAFKLHGQTQAAGFYEKLGYRTASEEFMLDGIPHVLMTKQDDSAL*" gene 3874765..3875208 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" CDS 3875291..3875770 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28032445; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391949.1" /db_xref="EnsemblGenomes-Gn:BSU40690" /db_xref="EnsemblGenomes-Tr:CAB16106" /db_xref="SubtiList:BG10028" /db_xref="UniProtKB/Swiss-Prot:P37501" /translation="MPANKKEGLIFGVMMCFGMVCVMSIYNAIINRAIYDFSLMTVFE MVIGFMIALLLDLLLVGPLAKKIAFRMPFDKTKKIYVILAMSTCMVIGMVLCMSVFGL VTAVLANGLNGDSLFSAYLMIVLKNFILAYPLQLLIMGPLVRGVFMKFVKPKLTAAI* " gene 3875291..3875770 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" downshifts 3875760 /Source="Nicolas_upshifts" /id="D2114" /incds=0 /nref=13 /ntot=97 /MaxReadThrough="0.69144" /MaxDrop="3.55998" /score="-9.53342462" /energy="-10.9" /TU="NA" /idTUdmin="U3210" /TUdmin=1628 /isTUend="FALSE" CDS complement(3875945..3876607) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391950.1" /db_xref="EnsemblGenomes-Gn:BSU40700" /db_xref="EnsemblGenomes-Tr:CAB16107" /db_xref="GOA:P37502" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10029" /db_xref="UniProtKB/Swiss-Prot:P37502" /translation="MNLRQLSEHVFQCEFELDVPLRIPVHTWFIKDGDDVYIVDTGIE RFADAQIRAALAIGNPKAILLTHGHSDHIGGASKWLERFDIPIFAHQKELKYINGEEP YPNKNEVENTGVAHIVQPLTEQTLAHLPLKYYLTPGHSPGHVVYYHKIDRTLLTGDLF ITSKEDLHPPIRRFSVDINENIDSGSIIDQIKPTLICSSHGEEILYNEELYKNYVVRY RD*" gene complement(3875945..3876607) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" CDS complement(3876754..3877206) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, polyamine export and degradation)" /protein_id="NP_391951.1" /db_xref="EnsemblGenomes-Gn:BSU40710" /db_xref="EnsemblGenomes-Tr:CAB16108" /db_xref="GOA:P37503" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10030" /db_xref="UniProtKB/Swiss-Prot:P37503" /translation="MNDILREIGMIARALDSISNIEFKDLDLTRGQYLYLVRIYENPG IIQEKLAEMIKVDRTTAARAIKKLEMQGFIQKLPDEQNKKIKKLFPTEKGKKVYPLLR REGEHSTEVALSGFTSEEKETISALLHRVRKNIERDWEYVKKGNKRDY*" gene complement(3876754..3877206) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" promotor_-35 3877230..3877237 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3877252..3877271 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3877254 /Source="Nicolas_upshifts" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" S_feature 3877256..3877325 /Source="Nicolas_S_feature" /locus_tag="new_4183947_4184016" /HighExp="G135, G180, H2O2, LoTm, G150, Salt, Diami, Paraq, LBGstat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1569" promotor_-10 complement(3877259..3877278) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3877261) /Source="Nicolas_upshifts" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" promotor_-35 complement(3877291..3877298) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3877326..3877772 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase (polyamine degradation)" /protein_id="NP_391952.1" /db_xref="EnsemblGenomes-Gn:BSU40720" /db_xref="EnsemblGenomes-Tr:CAB16109" /db_xref="GOA:P37504" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10031" /db_xref="UniProtKB/Swiss-Prot:P37504" /translation="MNIKRITTEADLHEALKIRRGVFIEEQHVSEADEFDEFDTLQEQ CQHILVYHENQPVGTGRARIVGHTAKLERICILKPYRKYGLGKIIVSGLEEIMKEKGL TSYKLHGQTQAAGFYQKLGYQISSQEFMEDGIPHVLMTKEISRNIT*" gene 3877326..3877772 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" CDS 3877769..3878374 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391953.1" /db_xref="EnsemblGenomes-Gn:BSU40730" /db_xref="EnsemblGenomes-Tr:CAB16110" /db_xref="SubtiList:BG10032" /db_xref="UniProtKB/Swiss-Prot:P37505" /translation="MKYMYYGIGILILSLGISLTIQSGLGTSPFDALLVGLSKKIGLT VGSWEVLISVILLICNAILTRKKPILLGLITAFITGIGIDLWLFVVKNTIYLNSLLSK LICFGIGLVLIGLGTAIYLQTKFASTPIDHLTLIIRDLSKRTILFSRTLVYALFLVLA IIFKGPIGIGTLLTVCLGGMLLHVFMPIVERHFLSKNRRGY*" gene 3877769..3878374 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" CDS complement(3878469..3878990) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16579456, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyl-transferase" /protein_id="NP_391954.1" /db_xref="EnsemblGenomes-Gn:BSU40740" /db_xref="EnsemblGenomes-Tr:CAB16111" /db_xref="GOA:P37506" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR008125" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10033" /db_xref="UniProtKB/Swiss-Prot:P37506" /translation="MIMKMTHLNMKDFNKPNEPFVVFGRMIPAFENGVWTYTEERFSK PYFKQYEDDDMDVSYVEEEGKAAFLYYLENNCIGRIKIRSNWNGYALIEDIAVAKDYR KKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFIIGAVDTMLYSNFP TANEIAIFWYYKF*" gene complement(3878469..3878990) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" S_feature complement(3878991..3879818) /Source="Nicolas_S_feature" /locus_tag="new_4185682_4186509_c" /HighExp="T0.30H, Lbstat, H2O2, LPhT, T1.0H, dia15, Diami, T1.30H, dia5, M9-stat" /AntisenseName="yyaQ" /AntisenseCor="0.51412050904654805" /AntisenseRegPval="-18.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1570" promotor_-35 3879039..3879046 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3879060 /Source="Nicolas_upshifts" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3879061..3879080 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3879126..3879400 /Source="Nicolas_S_feature" /locus_tag="new_4185817_4186091" /HighExp="LBGstat, G135, BC, G180, Sw, M9-stat, Diami, T0.30H, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13713" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1571" upshifts 3879126 /Source="Nicolas_upshifts" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" promotor_-35 3879129..3879134 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3879147..3879166 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3879401..3879757 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391955.1" /db_xref="EnsemblGenomes-Gn:BSU40750" /db_xref="EnsemblGenomes-Tr:CAB16112" /db_xref="InterPro:IPR007351" /db_xref="SubtiList:BG10034" /db_xref="UniProtKB/Swiss-Prot:P37507" /translation="MLTREDIFKHVKEKYGTSPDYPWEKYPNYASLRHTSNKKWYGLI MNVLPEKLGLDGHGEIDILNLKCPPEISDRLRNGENILPGYHMDKEHWISIVLERTDP EGEIYNLIEQSFHLTK*" gene 3879401..3879757 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" S_feature 3879758..3879916 /Source="Nicolas_S_feature" /locus_tag="new_4186449_4186607" /HighExp="Sw, BC, G135, H2O2, LBGstat, G180, LPhT, T0.30H, Diami, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1572" promotor_-10 complement(3879800..3879819) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3879818) /Source="Nicolas_upshifts" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" promotor_-35 complement(3879834..3879841) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3879917..3880483 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391956.1" /db_xref="EnsemblGenomes-Gn:BSU40760" /db_xref="EnsemblGenomes-Tr:CAB16113" /db_xref="GOA:P37508" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="PDB:2GD9" /db_xref="SubtiList:BG10035" /db_xref="UniProtKB/Swiss-Prot:P37508" /translation="MTNNLKQRRIILDLAVTLDGFIEGKNGEVDWCIMDPDMGFTDFL NQIDTILYGRKSFDLWGQYIPKNEDPDTEKELWKLVHSKKKYVFSRTQNEIDNQAIFI NDNILEEVNKLKKNPGKDIWLYGGASLITTFINLGLVDEFRLSIHPVVLGEGKPLFID VKQRINLKMVNTRTFSSGVVQIVYHWNG*" gene 3879917..3880483 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" CDS complement(3880990..3882366) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7961647, 14636065, 15849754, 16850406, 17015648, 25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7961647, 14636065, 15849754, 16850406, 17015648, 25954268; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multifunctional tetracycline-metal/H+ antiporterand Na+(K+)/H+ antiporter" /protein_id="NP_391957.1" /db_xref="EnsemblGenomes-Gn:BSU40770" /db_xref="EnsemblGenomes-Tr:CAB16114" /db_xref="GOA:P23054" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10036" /db_xref="UniProtKB/Swiss-Prot:P23054" /translation="MNTSYSQSTLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEF NKLPASANWVNTAFMLTFSIGTALYGKLSDQLGIKNLLLFGIMVNGLGSIIGFVGHSF FPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGG MVAHYIHWSYLLLIPTATIITVPFLIKLLKKEERIRGHIDMAGIILMSAGIVFFMLFT TSYRFSFLIISILAFFIFVQHIRKAQDPFVDPELGKNVFFVIGTLCGGLIFGTVAGFV SMVPYMMKDVHHLSTAAIGSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLS SGFLIAAFFIDAAPWIMTIIVIFVFGGLSFTKTVISTVVSSSLKEKEAGAGMSLLNFT SFLSEGTGIAIVGGLLSIGFLDHRLLPIDVDHSTYLYSNMLILFAGIIVICWLVILNV YKRSRRHG*" gene complement(3880990..3882366) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" CDS complement(3882400..3882462) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14636065, 17015648" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636065, 17015648; Product type t: transporter" /codon_start=1 /transl_table=11 /product="tetracycline resistance leader peptide" /protein_id="NP_391958.1" /db_xref="EnsemblGenomes-Gn:BSU40780" /db_xref="EnsemblGenomes-Tr:CAB16115" /db_xref="GOA:P23053" /db_xref="InterPro:IPR012618" /db_xref="SubtiList:BG11051" /db_xref="UniProtKB/Swiss-Prot:P23053" /translation="MKCNKMNRVQLKEGSVSMTL*" gene complement(3882400..3882462) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" promotor_-10 complement(3882483..3882502) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3882502) /Source="Nicolas_upshifts" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" promotor_-35 complement(3882515..3882522) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3882650..3882656 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3882672..3882691 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3882678 /Source="Nicolas_upshifts" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" CDS 3882715..3882954 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391959.1" /db_xref="EnsemblGenomes-Gn:BSU40790" /db_xref="EnsemblGenomes-Tr:CAB16116" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10037" /db_xref="UniProtKB/Swiss-Prot:P37509" /translation="MPNKSKPNRLIAEKSPYLLQHAHNPVDWFPWGEEAFAKAKRENK PVLVSIGYSTTCHWWPGIIKSCGTPLKDNRSHFKR*" gene 3882715..3882954 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" downshifts 3882963 /Source="Nicolas_upshifts" /id="D2115" /incds=0 /nref=7 /ntot=103 /MaxReadThrough="1.03879" /MaxDrop="3.89186" /score="10.758481" /energy="-8.2" /TU="NA" /idTUdmin="U3217" /TUdmin=9 /isTUend="TRUE" promotor_-35 3883047..3883054 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3883070..3883089 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3883086 /Source="Nicolas_upshifts" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" CDS 3883105..3883521 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948146, 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MerR family)" /protein_id="NP_391960.1" /db_xref="EnsemblGenomes-Gn:BSU40800" /db_xref="EnsemblGenomes-Tr:CAB16117" /db_xref="GOA:P37510" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG10038" /db_xref="UniProtKB/Swiss-Prot:P37510" /translation="MLLYSISKAAEKTSISSYTLRYYEKIGLLPPPKRKNSGRRFYTE TDIQFMLFLKSLKETGMSLEDINEFVKDGCILEKINSDVKSAQLSPSINKRIEILTKH LEKMEIKKRELEEVISTTKGKLDTYYSILKEEVENK*" gene 3883105..3883521 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" CDS 3883518..3884435 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391961.1" /db_xref="EnsemblGenomes-Gn:BSU40810" /db_xref="EnsemblGenomes-Tr:CAB16118" /db_xref="GOA:P37511" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10039" /db_xref="UniProtKB/Swiss-Prot:P37511" /translation="MKHLNIYIMLLGFSIFTGATFNLAKYTVGYFSPSSSAAWRFGLA AAVMLIILIFTEGIKKSQLRKNAVSYIVLGIIGIFGFNALFFVGLKYTSPVNGALIMG LNPLLTAILARIILKDNMTKKQVLGIFFAFIGVLLVITQGSIETIKTLSISGGDLIIF TGNVCWALYGVLGRRFVKDGTPLSTTTYTMVIGAVSLIVVSLFTSKPVSLSNIPIGVW GAIAFMAFFTSVLGYLWWNQGIKEIGASKTSLFFNLVPVVTMIISFAVGTPIKVFQVI GAVLVILGVLTASGVIRIPKYNTKEQSAI*" gene 3883518..3884435 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" misc_feature 3884462..3884481 /Source="Nicolas_upshift_promotors" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3884472 /Source="Nicolas_upshifts" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" promotor_-10 complement(3884476..3884495) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3884482) /Source="Nicolas_upshifts" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3884507..3886576 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391962.1" /db_xref="EnsemblGenomes-Gn:BSU40820" /db_xref="EnsemblGenomes-Tr:CAB16119" /db_xref="GOA:P37512" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR024705" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10040" /db_xref="UniProtKB/Swiss-Prot:P37512" /translation="MPNKSKPNRLINEKSPYLLQHAHNPVDWFPWGEEAFEKAKRENK PVLVSIGYSTCHWCHVMAHESFEDEEIARLLNERFVAIKVDREERPDVDSVYMRICQL MTGQGGWPLNVFITPDQKPFYAGTYFPKTSKFNRPGFVDVLEHLSETFANDREHVEDI AENAAKHLQTKTAAKTGEGLSESAIHRTFQQLASGFDTIYGGFGQAPKFPMPHMLMYL LRYDHNTGQENALYNVTKTLDSMANGGIYDHIGYGFARYSTDDEWLVPHFEKMLYDNA LLLTAYTEAYQVTQNSRYKEICEQIITFIQREMTHEDGSFFSALDADTEGEEGKYYVW SKEEILKTLGDDLGTLYCQVYDITEEGNFEGKNIPNLIHTKREQIKEDAGLTEKELSL KLEDARQQLLKTREERTYPHVDDKVLTSWNALMIAGLAKAAKVYQEPKYLSLAKDAIT FIENKLIIDGRVMVRYRDGEVKNKGFIDDYAFLLWAYLDLYEASFDLSYLQKAKKLTD DMISLFWDEEHGGFYFTGHDAEALIVREKEVYDGAVPSGNSVAAVQLLRLGQVTGDLS LIEKAETMFSVFKPDIEAYPSGHAFFMQSVLRHLMPKKEIVIFGSADDPARKQIIAEL QKAFKPNDSILVAEQPEQCKDIAPFAADYRIIDGKTTVYICENFACQQPTTNIEEAIH TLISSRD*" gene 3884507..3886576 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" promotor_-35 complement(3884509..3884516) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3886540 /Source="Nicolas_upshifts" /id="D2116" /incds=0 /nref=221 /ntot=260 /MaxReadThrough="1.24617" /MaxDrop="5.71843" /score="11.6894527" /energy="-16.6" /TU="NA" /idTUdmin="U3219" /TUdmin=0 /isTUend="TRUE" CDS complement(3886573..3887472) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11343912, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protease" /protein_id="NP_391963.1" /db_xref="EnsemblGenomes-Gn:BSU40830" /db_xref="EnsemblGenomes-Tr:CAB16120" /db_xref="GOA:P37513" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG10041" /db_xref="UniProtKB/Swiss-Prot:P37513" /translation="MNSFIRPIEGNNTLWRYFFAFLVMVGLYVLGNIAYLFAILFTVI VNPNITFDLDEAVLSDPLVDLYLSHVIYLFAIPGVWLAVRFILKRPFRTVITPNSKMN WRRISFGFIAYFLLMIAVQLIDFVIHPDSYSMQEFNASRFIWLLAAALILVPIQTSAE ELFFRGFLLQAFGRLTKNPLFLTLIVGGLFGVLHFANPEMNNGAVWAGIEYLTFGFVW TYYTIKTGSIEISLGAHAANNMFLCMFITEKNSVYGGIPSLFTVTRGNPMWEAFFTIA VNLVFAGIALWYHKKSKSKQQGS*" gene complement(3886573..3887472) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" downshifts complement(3886616) /Source="Nicolas_upshifts" /id="D2117" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="2.6155" /MaxDrop="3.91098" /score="23.2445146" /energy="-14.7" /TU="NA" /idTUdmin="U3221" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3887501..3887520) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3887517) /Source="Nicolas_upshifts" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" S_feature complement(3887519..3888750) /Source="Nicolas_S_feature" /locus_tag="new_4194210_4195441_c" /HighExp="S6, S8, S7, S5, B36, BT, S4, B60, S3, Diami" /AntisenseName="yyaJ" /AntisenseCor="-0.24400480530035801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1573" promotor_-35 complement(3887535..3887542) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3887613..3887620 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3887634..3887653 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3887640 /Source="Nicolas_upshifts" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" CDS 3887698..3889053 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 9529885, 19087206, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391964.2" /db_xref="EnsemblGenomes-Gn:BSU40840" /db_xref="EnsemblGenomes-Tr:CAB16121" /db_xref="GOA:P37514" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10042" /db_xref="UniProtKB/Swiss-Prot:P37514" /translation="MNTIFKQKNTHPFSNAANRLDRLPISRVHFQVLTALGIVYFFDL ADLFTLSNVAPALIEHWGIPLSTIANVTAASFLGMFLGASLGGRLSDRIGRKKALNLF VFVFSIASLCNAAAWDIPSLMTFRFLTGFGVAAAMVITNSYLAEFFPSSVRGKYISFC AMIGLIGVPITNIVSAFVIPLGSWGWRLVFVWGAVGLIYFFFIHRLEESPRWHENRGE YAKADAILTRIEEQVEKEKGPLPAASQPKVSETVKQNAGYAGLLKGRNLKITIVLSAV WIFETFGFYGFASWVPSLLKSNGVTMENTLWYNVLHSVGAPLGALLGSMISERFQRKW ILAASAFLTAIAGLLYGMTFIPIMIIVFGFIVNITERVFTSNLYAYTSEPYPTEYRSS GSGLAYGLGRFSNIFGSLLVGFIAVQLGYISVFLFIGGCWLACSLLLIFFGPNTNAKQ I*" gene 3887698..3889053 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" promotor_-10 complement(3888736..3888755) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3888760) /Source="Nicolas_upshifts" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" promotor_-35 complement(3888769..3888778) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3889087..3889641) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" gene complement(3889087..3889641) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" CDS complement(3889659..3890039) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" gene complement(3889659..3890039) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" CDS complement(3890095..3891030) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" gene complement(3890095..3891030) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" promotor_-35 3891020..3891029 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3891043..3891062 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3891050 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3891074..3891093) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3891088) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" CDS complement(3891089..3891847) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" gene complement(3891089..3891847) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" promotor_-35 complement(3891106..3891113) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3891380..3891883 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3891842 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" CDS complement(3891912..3892151) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" gene complement(3891912..3892151) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" downshifts complement(3891918) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" downshifts complement(3891986) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" CDS complement(3892195..3892713) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" gene complement(3892195..3892713) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" CDS complement(3892754..3893041) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" gene complement(3892754..3893041) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" S_feature complement(3893042..3893108) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3893107..3893126) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3893108) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" promotor_-35 complement(3893140..3893145) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3893152..3894252) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" gene complement(3893152..3894252) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" promotor_-10 complement(3894300..3894319) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3894315) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" promotor_-35 complement(3894334..3894341) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3894379..3896382) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" gene complement(3894379..3896382) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" CDS complement(3896433..3896639) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" gene complement(3896433..3896639) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" promotor_-10 complement(3896601..3896620) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3896626) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3896635..3896641) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3896665..3896684) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3896676) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" promotor_-35 complement(3896701..3896705) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3896733..3897749) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" gene complement(3896733..3897749) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" promotor_-10 complement(3897782..3897800) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3897794) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" promotor_-35 complement(3897816..3897821) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3897925) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" promotor_-35 3898109..3898114 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3898127..3898208 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3898127 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" promotor_-10 3898130..3898148 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3898209..3898826 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" gene 3898209..3898826 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" promotor_-35 3898797..3898805 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3898816 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" promotor_-10 3898819..3898837 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3898838 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3898865..3899713) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" gene complement(3898865..3899713) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" downshifts complement(3898885) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" CDS complement(3899706..3900467) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" gene complement(3899706..3900467) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" misc_feature complement(3900501..3900520) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3900519) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" upshifts complement(3900611) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" promotor_-10 complement(3900614..3900622) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3900636..3900644) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3900648..3900656 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3900664 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" promotor_-10 3900668..3900686 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3900715..3901155 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" gene 3900715..3901155 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" downshifts 3901104 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" CDS complement(3901206..3902057) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" gene complement(3901206..3902057) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" downshifts complement(3901225) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" S_feature complement(3902058..3902178) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3902179..3902898) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" gene complement(3902179..3902898) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" CDS complement(3902912..3904798) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" gene complement(3902912..3904798) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" CDS complement(3904819..3906198) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" gene complement(3904819..3906198) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" S_feature complement(3906199..3906329) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3906321..3906340) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3906329) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" promotor_-35 complement(3906356..3906360) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3906384..3906403) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3906394) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" promotor_-35 complement(3906417..3906424) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3906484..3906490 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3906495..3908780 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3906495 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" promotor_-10 3906505..3906524 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3906509..3907135) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" gene complement(3906509..3907135) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" downshifts complement(3906526) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" CDS complement(3907132..3907917) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" gene complement(3907132..3907917) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" promotor_-10 complement(3907962..3907981) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3907974) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" S_feature complement(3907976..3908061) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(3907993..3907999) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3908062..3908412) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" gene complement(3908062..3908412) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" S_feature complement(3908413..3908563) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(3908564..3908698) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" gene complement(3908564..3908698) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" promotor_no_box 3908722..3908822 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(3908734..3908753) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3908744) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" S_feature complement(3908746..3908814) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(3908769..3908776) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3908782..>3908915 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 3908782 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" promotor_-10 complement(3908800..3908819) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3908814) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" promotor_-35 complement(3908835..3908839) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" ORIGIN 1 atctttttcg gcttttttta gtatccacag aggttatcga caacattttc acattaccaa 61 cccctgtgga caaggttttt tcaacaggtt gtccgctttg tggataagat tgtgacaacc 121 attgcaagct ctcgtttatt ttggtattat atttgtgttt taactcttga ttactaatcc 181 tacctttcct ctttatccac aaagtgtgga taagttgtgg attgatttca cacagcttgt 241 gtagaaggtt gtccacaagt tgtgaaattt gtcgaaaagc tatttatcta ctatattata 301 tgttttcaac atttaatgtg tacgaatggt aagcgccatt tgctcttttt ttgtgttcta 361 taacagagaa agacgccatt ttctaagaaa aggagggacg tgccggaaga tggaaaatat 421 attagacctg tggaaccaag cccttgctca aatcgaaaaa aagttgagca aaccgagttt 481 tgagacttgg atgaagtcaa ccaaagccca ctcactgcaa ggcgatacat taacaatcac 541 ggctcccaat gaatttgcca gagactggct ggagtccaga tacttgcatc tgattgcaga 601 tactatatat gaattaaccg gggaagaatt gagcattaag tttgtcattc ctcaaaatca 661 agatgttgag gactttatgc cgaaaccgca agtcaaaaaa gcggtcaaag aagatacatc 721 tgattttcct caaaatatgc tcaatccaaa atatactttt gatacttttg tcatcggatc 781 tggaaaccga tttgcacatg ctgcttccct cgcagtagcg gaagcgcccg cgaaagctta 841 caacccttta tttatctatg ggggcgtcgg cttagggaaa acacacttaa tgcatgcgat 901 cggccattat gtaatagatc ataatccttc tgccaaagtg gtttatctgt cttctgagaa 961 atttacaaac gaattcatca actctatccg agataataaa gccgtcgact tccgcaatcg 1021 ctatcgaaat gttgatgtgc ttttgataga tgatattcaa tttttagcgg ggaaagaaca 1081 aacccaggaa gaatttttcc atacatttaa cacattacac gaagaaagca aacaaatcgt 1141 catttcaagt gaccggccgc caaaggaaat tccgacactt gaagacagat tgcgctcacg 1201 ttttgaatgg ggacttatta cagatatcac accgcctgat ctagaaacga gaattgcaat 1261 tttaagaaaa aaggccaaag cagagggcct cgatattccg aacgaggtta tgctttacat 1321 cgcgaatcaa atcgacagca atattcggga actcgaagga gcattaatca gagttgtcgc 1381 ttattcatct ttaattaata aagatattaa tgctgatctg gccgctgagg cgttgaaaga 1441 tattattcct tcctcaaaac cgaaagtcat tacgataaaa gaaattcaga gggtagtagg 1501 ccagcaattt aatattaaac tcgaggattt caaagcaaaa aaacggacaa agtcagtagc 1561 ttttccgcgt caaatcgcca tgtacttatc aagggaaatg actgattcct ctcttcctaa 1621 aatcggtgaa gagtttggag gacgtgatca tacgaccgtt attcatgcgc atgaaaaaat 1681 ttcaaaactg ctggcagatg atgaacagct tcagcagcat gtaaaagaaa ttaaagaaca 1741 gcttaaatag caggaccggg gatcaatcgg ggaaagtgtg aataactttt cggaagtcat 1801 acacagtctg tccacatgtg gataggctgt gtttcctgtc tttttcacaa cttatccaca 1861 aatccacagg ccctactatt acttctacta ttttttataa atatatatat taatacatta 1921 tccgttagga ggataaaaat gaaattcacg attcaaaaag atcgtcttgt tgaaagtgtc 1981 caagatgtat taaaagcagt ttcatccaga accacgattc ccattctgac tggtattaaa 2041 attgttgcat cagatgatgg agtatccttt acagggagtg actcagatat ttctattgaa 2101 tccttcattc caaaagaaga aggagataaa gaaatcgtca ctattgaaca gcccggaagc 2161 atcgttttac aggctcgctt ttttagtgaa attgtaaaaa aattgccgat ggcaactgta 2221 gaaattgaag tccaaaatca gtatttgacg attatccgtt ctggtaaagc tgaatttaat 2281 ctaaacggac tggatgctga tgaatatccg cacttgccgc agattgaaga gcatcatgcg 2341 attcagatcc caactgattt gttaaaaaat ctaatcagac aaacagtatt tgcagtgtcc 2401 acctcagaaa cacgccctat cttgacaggt gtaaactgga aagtggagca aagtgaatta 2461 ttatgcactg caacggatag ccaccgtctt gcattaagaa aggcgaaact tgatattcca 2521 gaagacagat cttataacgt cgtgattccg ggaaaaagtt taactgaact cagcaagatt 2581 ttagatgaca accaggaact tgtagatatc gtcatcacag aaacccaagt tctgtttaaa 2641 gcgaaaaacg tcttgttctt ctcacggctt ctggacggga attatccaga cacaaccagc 2701 ctgattccgc aagacagcaa aacagaaatc attgtgaaca caaaagaatt ccttcaggcc 2761 attgatcgtg catctctttt agctagagag ggacgcaaca acgttgtaaa actgtccgca 2821 aaaccggctg aatccattga aatttcttcc aattcgccag aaatcggtaa agttgtggaa 2881 gcaattgttg cggatcaaat tgaaggtgag gaattaaata tctcttttag tccaaaatat 2941 atgctggatg cactaaaggt gcttgaagga gcagaaatac gcgtaagctt tacaggcgca 3001 atgagacctt tcttaattcg cacgccgaat gatgaaacga ttgtacagct tatccttcct 3061 gtcagaacct attaatccga tacactgctg ccgacccgtc ggcagctttt ctattcggta 3121 tctgctccga caagttttcc ctttccctaa ttcgtttttt tttagtacaa ttagatatta 3181 gtgatatttg aaagaggtcg atataatggc aaatccgatt tcaattgata cagagatgat 3241 tacactcgga caattcttaa aattagccga tgtgattcag tctggcggta tggcgaagtg 3301 gtttttaagc gagcatgaag tgcttgtgaa cgatgagccg gacaaccgcc ggggcagaaa 3361 gctgtatgtt ggagatgtgg tagagattga aggatttggt tcatttcaag tcgtcaatta 3421 aagcgggtga cactgattgt atatccagaa cttagaactg acatcttacc gcaactacga 3481 ccatgctgaa cttcaatttg aaaataaagt aaatgtgatc atcggagaaa acgcccaggg 3541 gaagacaaac ctcatggagg cgatctatgt cttgtccatg gcgaaatcgc accggacatc 3601 aaatgacaaa gaacttatac ggtgggacaa agactatgct aaaatagagg gaagagtgat 3661 gaagcaaaac ggggcgatcc cgatgcagct cgtcatctcc aaaaagggta aaaagggcaa 3721 ggtcaatcat attgaacagc aaaagctcag ccagtatgtc ggggccctca acaccattat 3781 gttcgcgccg gaagatttaa atcttgtaaa gggaagccct caagtgagaa ggcggtttct 3841 tgacatggaa atcggacagg tttctcccgt ctaccttcat gatctttctc tttaccagaa 3901 aatcctttcc cagcggaatc attttttgaa acagctgcaa acaagaaaac aaactgaccg 3961 gacgatgctc gatgttctga ccgatcagct tgtagaagtt gcagcaaaag tcgtcgtaaa 4021 acgcctgcag tttacagcac agctcgagaa atgggcgcag cccatccatg caggcatctc 4081 aagagggctt gaagaactga ccctgaaata ccatacagct cttgatgtat cagatcccct 4141 agatttgtcg aaaataggag atagctatca agaagcgttt tctaaattaa gagaaaaaga 4201 aattgagcgt ggtgtgacgc tgtcagggcc tcatcgcgat gatgttcttt tctatgtgaa 4261 cggacgcgat gtgcagacgt atggttctca aggacagcag cgaacgacgg cgttgtccct 4321 taagctggcg gagattgacc tgatccatga agaaatcgga gaatatccca ttttactatt 4381 ggatgatgta ctgagtgaac tggatgatta tcgccagtca cacttgcttc atacgatcca 4441 aggccgtgta caaacgtttg tcacaacgac aagcgttgat ggcattgatc acgaaacctt 4501 acgtcaagca ggaatgttcc gtgtgcaaaa tggtgcgtta gtgaagtgaa gaaatgaggt 4561 gagcaattgt atattcattt aggtgatgac tttgtggttt caacacgaga tattgtcggc 4621 atttttgact ttaaagccaa catgtcgcct attgttgaag aatttctgaa aaaacagaaa 4681 cacaaggtgg tgccttccgt aaacggcacg cccaaatcta tcgtagtcac ggttcagaat 4741 atatattact ctcccttatc ttccagcaca ttaaaaaaac gtgcgcaatt tatgtttgaa 4801 atagattctt agaaattttt tatcacgaat atatcgttta gaaaagtgta ggtgaatgac 4861 gtggctatgg aacagcagca aaacagttat gatgaaaatc agatacaggt actagaagga 4921 ttggaagctg ttcgtaaaag accggggatg tatatcggtt cgacaaacag caaaggcctt 4981 caccacttgg tatgggaaat tgtcgacaat agtattgacg aagccctcgc cggttattgt 5041 acggatatca atatccaaat cgaaaaagac aacagtatca cggttgtaga taatggccgc 5101 ggtattccag tcggtattca tgaaaaaatg ggccgtcctg cggtagaagt cattatgacg 5161 gtgcttcatg ccggaggaaa atttgacgga agcggctata aagtatccgg aggattacac 5221 ggtgtaggtg cgtcggtcgt aaacgcacta tcaacagagc ttgatgtgac ggttcaccgt 5281 gacggtaaaa ttcaccgcca aacctataaa cgcggagttc cggttacaga ccttgaaatc 5341 attggcgaaa cggatcatac aggaacgacg acacattttg tcccggaccc tgaaattttc 5401 tcagaaacaa ccgagtatga ttacgatctg cttgccaacc gcgtgcgtga attagccttt 5461 ttaacaaagg gcgtaaacat cacgattgaa gataaacgtg aaggacaaga gcgcaaaaat 5521 gaataccatt acgaaggcgg aattaaaagt tatgtagagt atttaaaccg ctctaaagag 5581 gttgtccatg aagagccgat ttacattgaa ggcgaaaagg acggcattac ggttgaagtg 5641 gctttgcaat acaatgacag ctacacaagc aacatttact cgtttacaaa caacattaac 5701 acgtacgaag gcggtaccca tgaagctggc ttcaaaacgg gcctgactcg tgttatcaac 5761 gattacgcca gaaaaaaagg gcttattaaa gaaaatgatc caaacctaag cggagatgac 5821 gtaagggaag ggctgacagc gattatttca atcaaacacc ctgatccgca gtttgagggc 5881 caaacaaaaa caaagctggg caactcagaa gcacggacga tcaccgatac gttattttct 5941 acggcgatgg aaacatttat gctggaaaat ccagatgcag ccaaaaaaat tgtcgataaa 6001 ggtttaatgg cggcaagagc aagaatggct gcgaaaaaag cgcgtgaact aacacgccgt 6061 aagagtgctt tggaaatttc aaacctgccc ggtaagttag cggactgctc ttcaaaagat 6121 ccgagcatct ccgagttata tatcgtagag ggtgactctg ccggaggatc tgctaaacaa 6181 ggacgcgaca gacatttcca agccattttg ccgcttagag gtaaaatcct aaacgttgaa 6241 aaggccagac tggataaaat cctttctaac aacgaagttc gctctatgat cacagcgctc 6301 ggcacaggta tcggagaaga cttcaacctt gagaaagccc gttaccacaa agttgtcatt 6361 atgacagatg ccgatgttga cggcgcgcac atcagaacac tgctgttaac gttcttttac 6421 agatatatgc gccaaattat cgaaaatggc tacgtgtaca ttgcgcagcc gccgctctac 6481 aaggttcaac aggggaaacg cgttgaatat gcatacaatg acaaggagct tgaagagctg 6541 ttaaaaactc ttcctcaaac gcctaagcct ggactgcagc gttacaaagg tcttggtgaa 6601 atgaatgcca cccagctatg ggagacaacc atggatccta gctccagaac acttcttcag 6661 gtaactcttg aagatgcaat ggatgcggat gagacttttg aaatgcttat gggcgacaag 6721 gtagaaccgc gccgaaactt catagaagcg aatgcgagat acgttaaaaa tcttgacatc 6781 taatcataaa aagccttatt tccaataaga aataaggctt ttttctgaac aagatcagat 6841 gcagcgatgc ctgcaatacc tatatattct agcaatttaa tgtgtataat cataagttta 6901 ttgatataat ggagaatagt gaaatcgtat tgaaggtcat aatggacaat ctactcccac 6961 atatttcatg tgatacttca gggaggtttt ttaatgagtg aacaaaacac accacaagtt 7021 cgtgaaataa atatcagtca ggaaatgcgt acgtccttct tggattatgc aatgagcgtt 7081 atcgtgtccc gtgctcttcc ggatgttcgt gacggtttaa aaccggttca tagacggatt 7141 ttgtatgcaa tgaatgattt aggcatgaca agtgacaagc cttataaaaa atccgcgcgt 7201 atcgttggag aagttatcgg gaaataccac ccgcacggtg attcagcggt atatgaatcc 7261 atggtcagaa tggctcagga tttcaactac cgttatatgc tcgttgacgg tcacggaaac 7321 ttcggttctg ttgacggaga ctcagcggcg gccatgcgtt atacagaagc acgaatgtct 7381 aaaatctcaa tggagattct tcgcgacatc acaaaagaca caatcgatta ccaggataac 7441 tatgacgggt cagaaagaga acctgtcgtt atgccttcaa ggttcccgaa tctgctcgtg 7501 aacggtgctg ccggcattgc ggtaggtatg gcaacaaaca ttcctccgca ccagctggga 7561 gaaatcattg acggtgtact tgctgttagt gagaatccgg acattacaat tccagagctt 7621 atggaagtca ttccagggcc tgatttcccg accgcgggtc aaatcttggg acgcagcggt 7681 atccggaaag catacgaatc aggccgaggc tctatcacga tccgggcaaa agctgagatc 7741 gaacaaacat cttcgggtaa agaaagaatt atcgttacag agttacctta ccaagtaaat 7801 aaggcgaaat taattgagaa aattgctgat ctcgtaaggg acaaaaagat agagggtatc 7861 acagatctgc gtgatgagtc agatcgtaca ggtatgagaa ttgtcattga aatcagacgc 7921 gatgccaatg cgaatgttat cttaaacaat ctgtacaaac aaactgctct acaaacatct 7981 tttggcatca acctgcttgc gcttgttgat ggccagccga aagttttaac tcttaagcaa 8041 tgcctggagc attaccttga ccatcaaaaa gttgtcatta gacgccgtac tgcttatgaa 8101 ttgcgtaaag cagaagcgag agctcatatc ttggaaggat tgagagttgc actggatcat 8161 ctcgatgcag ttatctccct tatccgtaat tctcaaacgg ctgaaattgc gagaacaggt 8221 ttaattgaac aattctcact gacagagaag caagcacaag cgatccttga catgaggctc 8281 cagcgtttaa cgggactgga acgtgaaaag atcgaagaag aataccagtc tcttgttaaa 8341 ttaattgcag agctaaaaga catcttggca aatgaatata aagtgcttga gatcattcgt 8401 gaagaactca cggaaatcaa agagcgtttt aacgatgaaa gacgtactga gatcgtcact 8461 tctggactgg agacaattga agatgaagat ctcatcgaga gagaaaatat cgtagttact 8521 ctgacgcaca acggatacgt caaacgtctt cctgcatcaa cttaccgcag tcaaaaacgg 8581 ggcggaaaag gtgtacaagg tatgggaaca aacgaagatg atttcgttga acatttgatc 8641 tctacgtcaa ctcatgacac gattctcttc ttctcgaaca aggggaaagt gtatcgtgca 8701 aaagggtatg aaatccctga atacggcaga acggcaaaag gaatcccgat tattaacctg 8761 ctggaggtag aaaagggtga gtggatcaac gcgattattc cagtcacgga attcaatgcg 8821 gagctttacc tcttcttcac tacaaagcat ggggtttcaa aacgaacatc gctatctcaa 8881 ttcgctaata tccgcaacaa tggtctaatt gctctgagtc ttcgtgaaga tgatgaactg 8941 atgggtgtac gtctgactga cggcacaaaa caaatcatca ttggaacgaa aaacggttta 9001 ctgattcgtt tccctgaaac agatgtccga gagatgggaa gaactgcggc gggcgtaaaa 9061 ggcatcaccc tgacggatga cgacgttgtt gtcggcatgg agattttaga ggaagaatca 9121 cacgtcctta tcgtaactga aaaagggtac ggaaaacgaa ctcctgctga agagtacaga 9181 acccaaagcc ggggcggaaa aggactcaaa acagcgaaaa tcaccgagaa caacggccaa 9241 ctagtagcag tgaaagctac taaaggtgaa gaggatctaa tgattattac agctagcggc 9301 gtactcatca gaatggacat caatgatatc tccatcaccg gacgtgtcac tcaaggtgtg 9361 cgtctcatca gaatggcaga agaagagcat gttgctacag tagctttagt tgagaaaaac 9421 gaagaagatg agaatgaaga agaacaagaa gaagtgtgaa aaaaagcgca gctgaaatag 9481 ctgcgctttt ttgtgtcata accctttaca gtcataaaaa ttatggtata atcatttctg 9541 ttgtcttttt aaagacacaa gcatgaccat tatgactagt aaaaactttt tcaaaaaagt 9601 attgacctag ttaactaaaa atgttactat taagtagtcg ctttgagaga agcacacaaa 9661 gttctttgaa aactaaacaa gacaaaacgt acctgttaat tcatttttat aaatcgcaca 9721 gcgatgtgcg tagtcagtca aactagggcc tgcacgacgc aggtcacaca ggtgtcgccg 9781 caggatgcgg tgaacttaac ctgtgatcca tttatcggag agtttgatcc tggctcagga 9841 cgaacgctgg cggcgtgcct aatacatgca agtcgagcgg acagatggga gcttgctccc 9901 tgatgttagc ggcggacggg tgagtaacac gtgggtaacc tgcctgtaag actgggataa 9961 ctccgggaaa ccggggctaa taccggatgg ttgtttgaac cgcatggttc aaacataaaa 10021 ggtggcttcg gctaccactt acagatggac ccgcggcgca ttagctagtt ggtgaggtaa 10081 cggctcacca aggcgacgat gcgtagccga cctgagaggg tgatcggcca cactgggact 10141 gagacacggc ccagactcct acgggaggca gcagtaggga atcttccgca atggacgaaa 10201 gtctgacgga gcaacgccgc gtgagtgatg aaggttttcg gatcgtaaag ctctgttgtt 10261 agggaagaac aagtgccgtt cgaatagggc ggtaccttga cggtacctaa ccagaaagcc 10321 acggctaact acgtgccagc agccgcggta atacgtaggt ggcaagcgtt gtccggaatt 10381 attgggcgta aagggctcgc aggcggtttc ttaagtctga tgtgaaagcc cccggctcaa 10441 ccggggaggg tcattggaaa ctggggaact tgagtgcaga agaggagagt ggaattccac 10501 gtgtagcggt gaaatgcgta gagatgtgga ggaacaccag tggcgaaggc gactctctgg 10561 tctgtaactg acgctgagga gcgaaagcgt ggggagcgaa caggattaga taccctggta 10621 gtccacgccg taaacgatga gtgctaagtg ttagggggtt tccgcccctt agtgctgcag 10681 ctaacgcatt aagcactccg cctggggagt acggtcgcaa gactgaaact caaaggaatt 10741 gacgggggcc cgcacaagcg gtggagcatg tggtttaatt cgaagcaacg cgaagaacct 10801 taccaggtct tgacatcctc tgacaatcct agagatagga cgtccccttc gggggcagag 10861 tgacaggtgg tgcatggttg tcgtcagctc gtgtcgtgag atgttgggtt aagtcccgca 10921 acgagcgcaa cccttgatct tagttgccag cattcagttg ggcactctaa ggtgactgcc 10981 ggtgacaaac cggaggaagg tggggatgac gtcaaatcat catgcccctt atgacctggg 11041 ctacacacgt gctacaatgg acagaacaaa gggcagcgaa accgcgaggt taagccaatc 11101 ccacaaatct gttctcagtt cggatcgcag tctgcaactc gactgcgtga agctggaatc 11161 gctagtaatc gcggatcagc atgccgcggt gaatacgttc ccgggccttg tacacaccgc 11221 ccgtcacacc acgagagttt gtaacacccg aagtcggtga ggtaaccttt taggagccag 11281 ccgccgaagg tgggacagat gattggggtg aagtcgtaac aaggtagccg tatcggaagg 11341 tgcggctgga tcacctcctt tctaaggata ttttacggaa tataagacct tgggtcttat 11401 aaacagaacg ttccctgtct tgtttagttt tgaaggaact ttgttccttg aataagttaa 11461 gatgggcctg tagctcagct ggttagagcg cacgcctgat aagcgtgagg tcggtggttc 11521 gagtccactc aggcccacca tcttatataa cggggcctta gctcagctgg gagagcgcct 11581 gctttgcacg caggaggtca gcggttcgat cccgctaggc tccaccaacg tgttctttga 11641 aaactagata acagtagaca tcacattcaa ttagtaacac aagatatcac atagtgattc 11701 tttttaacgg ttaagttaga aagggcgcac ggtggatgcc ttggcactag gagccgatga 11761 aggacgggac gaacaccgat atgcttcggg gagctgtaag caagctttga tccggagatt 11821 tccgaatggg gaaacccacc actcgtaatg gagtggtatc catatctgaa ttcataggat 11881 atgagaaggc agacccgggg aactgaaaca tctaagtacc cggaggaaga gaaagcaaat 11941 gcgattccct gagtagcggc gagcgaaacg ggatcagccc aaaccaagag gcttgcctct 12001 tggggttgta ggacactctg tacggagtta caaaggaacg aggtagatga agaggtctgg 12061 aaaggcccgc cataggaggt aacagccctg tagtcaaaac ttcgttctct cctgagtgga 12121 tcctgagtac ggcggaacac gtgaaattcc gtcggaatcc gggaggacca tctcccaagg 12181 ctaaatactc cctagtgacc gatagtgaac cagtaccgtg agggaaaggt gaaaagcacc 12241 ccggaagggg agtgaaagag atcctgaaac cgtgtgccta caagtagtca gagcccgtta 12301 acgggtgatg gcgtgccttt tgtagaatga accggcgagt tacgatctcg tgcaaggtta 12361 agcagaagat gcggagccgc agcgaaagcg agtctgaata gggcgcatga gtacgtggtc 12421 gtagacccga aaccaggtga tctacccatg tccagggtga agttcaggta acactgaatg 12481 gaggcccgaa cccacgcacg ttgaaaagtg cggggatgag gtgtgggtag gggtgaaatg 12541 ccaatcgaac ctggagatag ctggttctct ccgaaatagc tttagggcta gcctcaaggt 12601 aagagtcttg gaggtagagc actgattgga ctaggggccc ctaccgggtt accgaattca 12661 gtcaaactcc gaatgccaat gacttatcct tgggagtcag actgcgagtg ataagatccg 12721 tagtcgaaag ggaaacagcc cagaccgcca gctaaggtcc caaagtatac gttaagtgga 12781 aaaggatgtg gagttgctta gacaaccagg atgttggctt agaagcagcc accatttaaa 12841 gagtgcgtaa tagctcactg gtcgagtgac tctgcgccga aaatgtaccg gggctaaacg 12901 tatcaccgaa gctgcggact gttcttcgaa cagtggtagg agagcgttct aagggctgtg 12961 aagccagacc ggaaggactg gtggagcgct tagaagtgag aatgccggta tgagtagcga 13021 aagaggggtg agaatcccct ccaccgaatg cctaaggttt cctgaggaag gctcgtccgc 13081 tcagggttag tcgggaccta agccgaggcc gaaaggcgta ggcgatggac aacaggttga 13141 tattcctgta ccacctcctc accatttgag caatgggggg acgcaggagg atagggtaag 13201 cgcggtattg gatatccgcg tccaagcagt taggctggga aataggcaaa tccgtttccc 13261 ataaggctga gctgtgatgg cgagcgaaat atagtagcga agttcctgat tccacactgc 13321 caagaaaagc ctctagcgag gtgagaggtg cccgtaccgc aaaccgacac aggtaggcga 13381 ggagagaatc ctaaggtgat cgagagaact ctcgttaagg aactcggcaa aatgaccccg 13441 taacttcggg agaaggggtg ctctgttagg gtgcaagccc gagagagccg cagtgaatag 13501 gcccaggcga ctgtttagca aaaacacagg tctctgcgaa gccgtaaggc gaagtatagg 13561 ggctgacgcc tgcccggtgc tggaaggtta agaggagcgc ttagcgtaag cgaaggtgcg 13621 aattgaagcc ccagtaaacg gcggccgtaa ctataacggt cctaaggtag cgaaattcct 13681 tgtcgggtaa gttccgaccc gcacgaaagg cgcaacgatc tgggcactgt ctcaacgaga 13741 gactcggtga aattatagta cctgtgaaga tgcaggttac ccgcgacagg acggaaagac 13801 cccgtggagc tttactgcag cctgatattg aatgttggta cagcttgtac aggataggta 13861 ggagccttgg aaaccggagc gccagcttcg gtggaggcat cggtgggata ctaccctggc 13921 tgtattgacc ttctaacccg ccgcccttat cgggcgggga gacagtgtca ggtgggcagt 13981 ttgactgggg cggtcgcctc ctaaaaggta acggaggcgc ccaaaggttc cctcagaatg 14041 gttggaaatc attcgcagag tgtaaaggca caagggagct tgactgcgag acctacaagt 14101 cgagcaggga cgaaagtcgg gcttagtgat ccggtggttc cgcatggaag ggccatcgct 14161 caacggataa aagctacccc ggggataaca ggcttatctc ccccaagagt ccacatcgac 14221 ggggaggttt ggcacctcga tgtcggctca tcgcatcctg gggctgtagt cggtcccaag 14281 ggttgggctg ttcgcccatt aaagcggtac gcgagctggg ttcagaacgt cgtgagacag 14341 ttcggtccct atccgtcgcg ggcgcaggaa atttgagagg agctgtcctt agtacgagag 14401 gaccgggatg gacgcaccgc tggtgtacca gttgttctgc caagggcatc gctgggtagc 14461 tatgtgcgga cgggataagt gctgaaagca tctaagcatg aagcccccct caagatgaga 14521 tttcccattc cgcaaggaag taagatccct gaaagatgat caggttgata ggtctgaggt 14581 ggaagtgtgg cgacacatgg agctgacaga tactaatcga tcgaggactt aaccatattt 14641 ttgaatgatg tcacacctgt tatctagttt tgagagaaca ctctcaattt gtttggtggc 14701 gatagcgaag aggtcacacc cgttcccata ccgaacacgg aagttaagct cttcagcgcc 14761 gatggtagtc gggggtttcc ccctgtgaga gtaggacgcc gccaagcaag cttaaaccca 14821 gctcaatgag ctgggttttt tgtttgttaa aaatgaagaa gaaactgtga agcgtattta 14881 gggaatttct tttctgatac taataaaaac tgctgaatta acacgtagtc atcacttata 14941 tgctgtgtta ataactcata ccaccattct gtttcatacc ttgcaatcat cccaacgttg 15001 tacaaaatca aataatgaat tgtcatttcg ggaagcctca gaaattgctc cctttgagaa 15061 gggatataat attggttctt ttccatgtca aacaataagc tggtcgatgt ccatggctcc 15121 ttgtcttgtg gtgaaatttc gaacagcagc ccgtgttcat ttttttttgt aaaagaccat 15181 tgataatgat gggacatgta ttcagcaaac cttgaatcag acattttgta attgattact 15241 acttcctccg gtacaaaaat ttcgttctta tccttctcaa cttttgtcat aaatcgttct 15301 ttctgctgaa agtagaaaat atcgctaagt tctggaatgg ccattaataa ttttttcatg 15361 gtataccgtt catctactat atccgattgt ccgaataaat gtttcataaa atgtacgcat 15421 aggccattcc gttgtatttt cacttcatcg tcgctaaaac aataattttg tttctttcgt 15481 tttcttgttg ttacgccatg tgccagtact gatgtatggc ttggataatg aggatcacgt 15541 gtaattaagc atgctttgat aagctgtgcc attccataaa ataaaagaat cggtttgatt 15601 tctaagggag aatatgcggc ttgtttataa aacgattcgg catgctttaa gaaataaata 15661 aaccgttcac tgtttttaaa agagtttttt ttcgcatcgt taataccgtt taagatataa 15721 accttttcta gaaatttctg ggttgattca acggagtaaa atagcgctaa gtctttccac 15781 tcatgatatg tcatgtatat ttcttaatcc tttccgttat ctaaatattt caactctttc 15841 ccgcttcctt gacatgctct tggctagttg ataatctaca tataatattt tgccgaaaag 15901 agggggattt actaatgtgg gaaagtaaat tttcaaaaga aggcttaacg ttcgacgatg 15961 tgctgcttgt accagcaaag tctgaggtac ttccgcgtga tgtggattta tctgtagaac 16021 ttacaaaaac gttaaagcta aatattcctg tcatcagcgc aggtatggac actgtaacag 16081 aatcagcaat ggcaattgca atggcaagac agggcggctt gggcatcatt cacaaaaata 16141 tgtccattga acagcaggct gaacaagttg ataaagtaaa gcgttctgag cgcggcgtta 16201 tcacaaatcc cttcttttta actcctgatc accaagtatt tgatgcggag catttgatgg 16261 ggaaatacag aatttccggt gttccgattg taaataacga agaagaccag aagcttgttg 16321 gaattattac aaaccgtgac cttcgtttta tttctgacta ctcaatgaaa atcagcgacg 16381 tcatgacgaa agaagagcta gttactgcat ctgtaggaac tactctggat gaagctgaaa 16441 agattttgca gaaacataaa attgaaaagc ttcctctcgt agatgaccag aataaattaa 16501 aaggtcttat cacaattaaa gacattgaaa aagtcattga gttcccgaac tcatctaaag 16561 acattcacgg ccgcctgatc gttggcgcgg cagttggtgt aactggcgat acaatgactc 16621 gcgtcaaaaa gcttgttgaa gccaatgttg atgtgattgt tatcgataca gctcacggac 16681 actctcaagg cgttttaaac acagtcacaa aaatccgtga aacgtatccc gaattaaaca 16741 ttattgctgg aaacgtggca acagctgaag cgacaagagc gcttatcgaa gctggagcag 16801 acgttgtcaa agttggaata gggcctggtt caatttgtac tacacgtgtt gtagccggcg 16861 tgggtgttcc gcaaattaca gcaatttatg attgtgcgac tgaagcaaga aaacacggca 16921 aaacaatcat cgccgacggt gggattaaat tctctggcga tatcactaaa gcattggcag 16981 ccggcggaca tgctgttatg ctcggaagct tgcttgcagg cacatcagaa agccctggtg 17041 aaactgaaat ctaccaaggc agaagattta aggtataccg cggcatggga tcagttgctg 17101 caatggaaaa aggaagtaaa gaccgttact tccaagaaga aaacaaaaaa tttgttcctg 17161 aaggaattga aggacgcaca ccttacaaag ggccagttga agaaaccgtt tatcagctag 17221 tcggaggcct tcgttctggt atggggtatt gcgggtccaa agatctgcgt gcgctaagag 17281 aagaagctca gttcattcgc atgactggcg caggacttcg cgaaagccat ccgcatgacg 17341 tacagattac aaaagaatca cctaactata caatttcata ataaattgtt acaaattaaa 17401 aacatttgac agggtctctg actctgtcta ttttttttat actgattatg ataaaattta 17461 tactgttgtg cattgaaaat gtccttaacg gcttaattat agatgaagaa aatgaaatac 17521 ggaggtcgta cgattgaaca tcaagaaatg taaacagcta ctgatgtcat tggttgtgtt 17581 aactctagct gtcacgtgtc tggctccaat gtcaaaagcg aaagcagcca gcgatccaat 17641 tgatatcaat gcatctgctg ctattatgat cgaagcttct tcaggtaaaa ttctttacag 17701 taaaaatgca gataagagac tgccaattgc gagtatgaca aaaatgatga cagagtatct 17761 gttattggaa gcaattgatc aaggtaaagt gaaatgggac caaacctata cgcctgatga 17821 ctatgtgtat gaaatttccc aagataacag cttatcaaac gttcctcttc ggaaagacgg 17881 gaaatacaca gtaaaagaat tatatcaagc tacagcaatt tattctgcaa atgctgctgc 17941 tattgcgatt gcagaaatcg ttgccggttc tgaaactaag tttgttgaaa aaatgaatgc 18001 aaaagcaaaa gaactaggct taacagatta caaatttgtt aacgcaacag gtcttgaaaa 18061 caaagatctt cacgggcatc agcctgaggg gacaagcgta aatgaagaaa gtgaagtttc 18121 tgcaaaggat atggcggttc ttgcggatca cttgattact gactaccctg agatactgga 18181 gacttccagt atcgccaaaa cgaaattcag agaaggcacc gatgatgaaa tggacatgcc 18241 gaactggaat tttatgctga aggggcttgt cagcgagtat aaaaaagcga ctgtagacgg 18301 actgaaaaca ggttctactg actctgcggg ttcatgcttt acaggaacag ctgaacgcaa 18361 cggtatgcgt gtcatcactg ttgttttaaa cgcaaagggc aaccttcata caggccgttt 18421 cgatgaaacg aaaaaaatgt ttgattatgc tttcgacaat ttctccatga aagaaattta 18481 tgctgaaggc gatcaagtaa aaggccataa aacaatttca gttgataagg gtaaagagaa 18541 agaagtaggc attgtgacaa acaaggcgtt ctctcttcct gtcaaaaatg gtgaagaaaa 18601 gaattacaaa gcgaaggtca cactgaataa agacaactta actgctcctg tgaaaaaagg 18661 aaccaaggtt gggaagctga ctgcggaata cacaggtgat gaaaaggatt acggattcct 18721 taacagcgat ctggctggcg tagaccttgt tacaaaagaa aatgtagaaa aagcaaactg 18781 gtttgttttg acaatgcgca gtatcggcgg attttttgcc ggaatttggg gaagcattgt 18841 tgatacggta accggctggt tttaatcaat tgaaagagct ctgatggatg ttagggctct 18901 ttcgcgtaat atactgaaaa aacccaattt ttaataaaaa atgattttca aagcgctaaa 18961 aaccgaataa aatagtatat atgcatatga attattggat ttctaggata caataaggat 19021 tagaaatcat ataactatac cttgattagg gggaccaaga aatggctcaa acaggtactg 19081 aacgtgtaaa acgcggaatg gcagaaatgc aaaaaggcgg cgtcatcatg gacgtcatca 19141 atgcggaaca agcgaaaatc gctgaagaag ctggagctgt cgctgtaatg gcgctagaac 19201 gtgtgccagc agatattcgc gcggctggag gagttgcccg tatggctgac cctacaatcg 19261 tggaagaagt aatgaatgca gtatctatcc cggtaatggc aaaagcgcgt atcggacata 19321 ttgttgaagc gcgtgtgctt gaagctatgg gtgttgacta tattgatgaa agtgaagttc 19381 tgacgccggc tgacgaagaa tttcatttaa ataaaaatga atacacagtt ccttttgtct 19441 gtggctgccg tgatcttggt gaagcaacac gccgtattgc ggaaggtgct tctatgcttc 19501 gcacaaaagg tgagcctgga acaggtaata ttgttgaggc tgttcgccat atgcgtaaag 19561 ttaacgctca agtgcgcaaa gtagttgcga tgagtgagga tgagctaatg acagaagcga 19621 aaaacctagg tgctccttac gagcttcttc ttcaaattaa aaaagacggc aagcttcctg 19681 tcgttaactt tgccgctggc ggcgtagcaa ctccagctga tgctgctctc atgatgcagc 19741 ttggtgctga cggagtattt gttggttctg gtatttttaa atcagacaac cctgctaaat 19801 ttgcgaaagc aattgtggaa gcaacaactc actttactga ttacaaatta atcgctgagt 19861 tgtcaaaaga gcttggtact gcaatgaaag ggattgaaat ctcaaactta cttccagaac 19921 agcgtatgca agaacgcggc tggtaagaac ataggagcgc tgctgacatg ttaacaatag 19981 gtgtactagg acttcaagga gcagttagag agcacatcca tgcgattgaa gcatgcggcg 20041 cggctggtct tgtcgtaaaa cgtccggagc agctgaacga agttgacggg ttgattttgc 20101 cgggcggtga gagcacgacg atgcgccgtt tgatcgatac gtatcaattc atggagccgc 20161 ttcgtgaatt cgctgctcag ggcaaaccga tgtttggaac atgtgccgga ttaattatat 20221 tagcaaaaga aattgccggt tcagataatc ctcatttagg tcttctgaat gtggttgtag 20281 aacgtaattc atttggccgg caggttgaca gctttgaagc tgatttaaca attaaaggct 20341 tggacgagcc ttttactggg gtattcatcc gtgctccgca tattttagaa gctggtgaaa 20401 atgttgaagt tctatcggag cataatggtc gtattgtagc cgcgaaacag gggcaattcc 20461 ttggctgctc attccatccg gagctgacag aagatcaccg agtgacgcag ctgtttgttg 20521 aaatggttga ggaatataag caaaaggcac ttgtataaaa cagttgaaag ctgtggaaac 20581 ttatagtaca ttataagcac aaataaagat cgaaaagcgt tgataggaac tagtagggag 20641 cctctctttc taagagagcc gatggttggt gcgaatcggt gaaagatgct gtctgaatcc 20701 atccttgagc gaaatgctga agcgagtagg catttacggg ataaccgtta tgtttgaaag 20761 tggaaaacga gtctttgatt tgttttcaat cagggtggca acgcgagagc tctcgtccct 20821 ttatggggat gagggctctt tttattttcg ataaatcaat aaaaaaagga gtgtttcgca 20881 tgcttgatac gaaaatgctg agagcaaatt ttcaagaaat taaagcaaag cttgtacaca 20941 aaggcgaaga cttaactgat tttgataagt ttgaggcgct ggatgataga cgaagagagc 21001 ttatcggcaa ggttgaagag ttaaaaggaa aacgaaatga agtttctcag caggttgctg 21061 tgctgaagcg tgagaaaaaa gacgcggatc acattattaa agaaatgcgt gaagtcggcg 21121 aggaaattaa aaagctcgat gaagaattac ggacagtgga agctgagctt gatacaatcc 21181 tgctctcaat cccgaatatt ccgcatgagt ctgtacctgt cggtgaaaca gaagacgaca 21241 acgtagaagt gcgtaaatgg ggtgaaaagc cttcatttgc ttatgagccg aagccgcact 21301 gggatattgc ggatgagctg ggtattctgg attttgaacg tgctgccaaa gtaacaggaa 21361 gccgtttcgt gttctataaa ggcttaggtg ctcgtctgga gcgtgcgctt tataacttta 21421 tgcttgatct gcatgtggat gagtataact acactgaagt gatcccgcca tatatggtaa 21481 accgcgcaag catgacggga acggggcagc ttcctaaatt tgaagaggat gcatttaaaa 21541 tcagagaaga agattatttc ttaattccaa cggcggaagt gccgattaca aacatgcatc 21601 gcgatgaaat cctttcaggt gacagcctgc cgatcaacta tgcggcattc agtgcttgct 21661 tccgttctga agctggttca gcaggacgtg acacacgcgg attaattcgt cagcaccaat 21721 ttaataaagt tgagcttgta aagtttgtga agcctgaaga ttcttatgaa gaattagaga 21781 aacttacaaa ccaagcagaa cgggttcttc agctgcttga gcttccatac cgtgtcatga 21841 gcatgtgtac gggtgactta ggctttacgg ctgcgaaaaa atacgatatc gaagtttgga 21901 ttccaagcca agacacatat cgagaaatct cttcttgcag caacttcgaa gcgttccagg 21961 cgagacgtgc gaatattcgt ttcagacgtg aagcgaaagg caagcctgag catgtacaca 22021 cactgaacgg ctcaggactg gcggttggaa gaacagttgc tgctatctta gaaaattatc 22081 agcaggaaga cggaagcgtt gtgattccga aagtgcttcg tccttatatg gggaatagag 22141 aagtaatgaa accgtaaatt atggaaaggc gtgcctgaca aggtgcgcct ttttgcttat 22201 gtaaacacgg cattttcata aaaacaaaaa aagtttttaa aaatgcttga ccacacgaga 22261 acatacgtga tatagttagt cttgtcgata cggaggaata cccaagtccg gctgaaggga 22321 tcggtcttga aaaccgacag gggtgtcaaa gcccgcgggg gttcgaatcc ctcttcctcc 22381 gccatattga ttttaattct aatgaaacac aagcatatat tggagattgt tttgtccgtt 22441 gcattcggtg cggcggattt tttattttaa agaaaaagtg aatctcgact gagattcact 22501 ttttttgatt atcatgaata actgaagcaa tttgatctac aatattttca atcgagtttt 22561 cgtcgttcag aagatcataa tcttcaatgc gaagttttaa aacagggcag gcattaaaac 22621 cgcttatcca gttctcgtag cgtgtatgca tttcttccca ataagaccgg cttgtctgaa 22681 gctccatctc acggccgcgt tgttcaatcc ggtttaaaat gttctccaga tctccttcta 22741 aatagatcaa cacatctgga tgtgggaaat acggtgtcat taccattgct tcgaaaaggc 22801 ttgtgtaagt cttataatca acctttgaca ttgtcccttt atcagcatgc atttttgcga 22861 aaattcctgt atcttcataa atcgaacgat cctgtacaaa acctccgccg gcttcaaaaa 22921 ttgttttctg ttctttgaag cgttcagcta agaagtaaat ttgaaggtga aagctccaac 22981 gttcaaaatc atgatagaac ttttccaaat atggattatg atcgacttcc tccaacgatg 23041 ttttaaatcc aagccgttta gctaaagttt ttgttaaagt cgattttccg acacctactg 23101 ttcctgctac tgtaataatt gaattcttag ggatatgatg ttccttcata cgataagctc 23161 ctttacatgg gcggcaatgc gttcaaagtc gctcttattc aaaacgaaat cctttgaatc 23221 accatctacg gttaacactg taagttcagg gtctgcttcc tgcagctgct tgatggcgac 23281 ttcataatct gaaatcagct gctccaaata gctagtttca atttttttct caaaggggcg 23341 cccgcgtttt tcaatgcggt gtagcaatgt aggcagactg gcctttatgt aaatgatgaa 23401 attcggcttt ggcagatcat ccgttagcag gtgatatatc tttttgtatt tttccagctg 23461 atgtggagac aaggttcgtt ccgcaaaaat cacattttta taaatatgat aatcagctat 23521 tacaggctgt ccctttttta aaaagtgatc actggtgtct tcaagctgtt tgtatctgtg 23581 acaaagaaaa aacatctcga gctggaagct ccattccttt atattgtcat aaaacttatc 23641 aaggtacggg ttatcctcta caatctcatt gatcataggg aatccgaatt tttgtgagag 23701 catcgttgcg agagttgttt ttcctgcccc gataggacct tctattgcaa taaaaggggc 23761 tgtattcatc ggaatcctcc ttatatctga aaaacgtgcg tcagttaccg accttcatat 23821 tgtatcacaa cccttgggtg cccccatgaa aaaaagacgt ttccaaatta tcgaaacgtc 23881 tttttgacaa cattaaattg atcagacagc agcagccagt tttgtggaaa ggaaagaccc 23941 agcttccaat agctgatgcc tcttaaattc agctctttaa tcagattgaa ttttgcttga 24001 atcgagcggg catcctcgaa ccatacctcg tgccttctgt tttctgcatc agtatagcgg 24061 aagaaaggag cttgagcggt ttggtcatac tgaatggaag cattgttctg atcagctatg 24121 acaatggctt gctgagggct tactgctctt gctggagttc cccctgctgt atatggcagc 24181 gtccagtcat atccatataa attctggccc atgacaattt tgttcgcagg catttcagtc 24241 aaagcatatt ctatgacatc acggacaggt ccaattggag aaaccgcttg aggcggtccg 24301 ccgctatagc cccattcata tgtcatgaga acaacaaagt cgacaatttc gccatgtgcc 24361 ctgtaatcat gagcttcata ccacctgccc tgctgtgttg cacttgtttt aggagcaaga 24421 gccgtagaaa tttctaagcc ctctcgatgg aaaagatccc ttgcttcgcg gaggaattga 24481 ttataggcct ctctatcctg gggccgcaaa tattcaaagt cgaaatgaat gtcacggaag 24541 ccatatcttc tggcattctc gactatttca tttagaagcc gtctttttac agtttcgtcg 24601 ttcaaaagga tccggccaag ttcatcgctg aatgcctggt tttctaggtt cgttataatc 24661 atcatcaatg ttgtattttg actttctgta atgctcctta aattcgttaa aggcggtgcg 24721 actaaggttc cgttccgctg tgcctggaag ctgaatgcgc caaggtaagt taagtagggc 24781 gacgcttctc tggccgcctg ctggagattt tcgctgactt gatttcctcg gggctccaaa 24841 taagcatttg attcgatgtc tcgtttagga gctggaggga tgtataaacg gaaaccaatc 24901 tgaagcacgg tatttaactg gatgcggtta acccttgcga gctcggctgc tgttgtattg 24961 aactgccggg cgatggatgt cagggtatca cctcgcttca catcatagaa ctggccagct 25021 attggaatga caatggtttg tccgacaaca aggctgtcgg gattcggtat ttcattcgtt 25081 tcagtgatgt catttgtggt tgttctgtat tgtgaagcga tagcagaaag agtgtcgcct 25141 tgttttacca cataaatttg aatgaaaaac gcctcctttc atatcgctat caatgtatga 25201 aagaaaagcg ctgatcatgt ttatttttct ataatttgtt cttccgtcgt aatttctgcg 25261 aaaagaacat tctccatcat ggttaaggcg aattcgttat cttcgtcact gtttgacgcg 25321 atacagtcct taggaatcgt gatgctgtat tccctcatat aagcgtcatt agcggtaaac 25381 agcacgcata tattgccggc tatacctgtt atgataatat gtctcacctg caactcagta 25441 agaagggtgt gaagtgctgt ttcgtagaaa gcggaatgtt tcggtttgat taaaaaataa 25501 tcagcatcta ccggagctat ctttgtgatg atatccttgc ttctttcatt tgtgcattct 25561 tgctgtatgt ttttaatgtc agcttgccaa agtccataat gatcattgat gtaaataatc 25621 ggccattcat tttgtctcgc gtgctccttt aatgataaaa tatgaggaac gattttttct 25681 gtttttttag cgagggtttc ccccatatcg aattcaaaat tattgatcat gtctacaatg 25741 agaagggctt tatctgcttt ggacaatcga cagtctcctt tccgtttcag ttatagttaa 25801 tatgtagcct ttttaggcaa tgaaaaaact ttgaaaagag agcttatcct tatgacacaa 25861 gatgaacttt atatgaaaga agcaattaaa gaagcgaaaa aggctgaaga gaaaggtgaa 25921 gtgccaatag gtgcggtgct tgtcattaat ggtgaaatta tagcgcgtgc gcataattta 25981 agagagactg aacagcgatc tattgcccat gcagaaatgc ttgtaattga tgaagcgtgt 26041 aaggcactcg gaacatggcg gctggaaggt gcgactcttt atgtgacgct tgagccttgt 26101 ccaatgtgtg ctggtgcagt cgtactttct cgagtggaaa aagtggtttt tggcgcattt 26161 gatccgaaag gcggctgttc aggcacgcta atgaaccttc ttcaggagga acgctttaat 26221 catcaggctg aagtggtgag cggtgtgctt gaggaagaat gcggcggaat gctcagtgcg 26281 tttttcagag aactaagaaa aaagaagaaa gccgccagga aaaacttgtc tgaatagtac 26341 ggttgcaatt tttaggggaa acagatatac ttaagtgtgc atcgtaatag atgcaacata 26401 aaatttgata tttattttgc cgtgctaagc ggggaggtag cggtgccctg tacctgcaat 26461 ccgctctagc agggccgaat cccttctcga ggttcgttta ctttaaggcc tgccttaagt 26521 aagtggtgtt gacgtttggg tcctgcgcaa tgggaattca tgaaccatgt caggtccgga 26581 aggaagcagc attaagtgaa acctctcatg tgccgcaggg ttgcctgggc cgagctaact 26641 gcttaagtaa cgcttagggt agcgaatcga cagaaggtgc acggtaaatc aatcatcaaa 26701 ttttcagact cacctaatat taggtgagtt ttttgttatg taaaaagagc ttttggaatc 26761 gaaacaaggt tcatgtataa tgggaatgat gaataacgga ggagggcaaa cccgtgagtt 26821 accaagcttt atatcgagta ttcaggcctc agcgctttga agatgtggtc ggacaagaac 26881 acattacaaa aacgctgcaa aatgcccttt tgcaaaaaaa gttttctcac gcctatctgt 26941 tttccgggcc tagaggaacc ggaaaaacca gtgcagccaa aatatttgct aaggctgtca 27001 actgtgaaca tgctcctgtt gatgagccat gcaacgaatg tgcggcctgt aaagggataa 27061 caaacgggtc aatatccgat gtcatagaaa ttgacgccgc ttctaataac ggtgttgatg 27121 agattcgtga cattcgcgat aaagtgaagt ttgccccatc ggccgtcaca tataaggtat 27181 atatcataga tgaggtgcat atgctttcta tcggcgcttt taatgcatta ctaaaaacat 27241 tagaagagcc gcctgagcat tgtattttca tattagcaac aactgaaccg cacaaaattc 27301 ctttaaccat tatctctaga tgtcagcgtt ttgactttaa acgaattacc tcccaagcga 27361 ttgtaggccg catgaataaa attgttgatg ctgaacagct gcaagtggag gaaggatcgc 27421 tggaaatcat cgcgagtgct gcagacggag ggatgaggga tgccctgagc cttcttgatc 27481 aggccatatc attcagcggc gatatcctga aagtcgaaga tgcgctttta attacgggtg 27541 ctgtttctca attatatatc gggaagcttg caaaatccct gcatgataaa aacgtttctg 27601 acgcactgga aacattaaat gaattgcttc agcaaggaaa agatccagct aagctgatag 27661 aagatatgat tttctatttc agggacatgc tgctgtacaa aacagcccct ggcttagagg 27721 gagtgcttga gaaagtaaaa gtcgatgaaa cgttccggga actaagtgaa caaattccgg 27781 ctcaggccct atatgaaatg attgatattc tgaacaagag ccatcaggaa atgaaatgga 27841 caaatcatcc gcgtatcttt ttcgaagtgg ccgttgtgaa gatttgccaa acctcacatc 27901 aatctgctgc tgatctcccg gaagtggata tgctgatgaa aaaaatccag cagctcgaac 27961 aggaagtaga gcggctcaaa acaacgggca taaaagcagc tgcggaaagc ccgaaaaaag 28021 aagcgccgcg tgtgccaaag ggcgggaaat ccaattacaa agcgccagta ggcagaattc 28081 atgagatttt gaaggaagcc acaagaccgg atcttgatct gctcagaaac agttggggca 28141 agcttcttgc tcatctcaaa cagcaaaaca aagtatcaca tgccgctttg ctgaatgaca 28201 gtgaacctgt ggctgccgga tcggcggcat ttgttctgaa attcaaatat gaaattcatt 28261 gtaaaatggt cgctgaggat aacaacggag tccggactaa tcttgagcag attttagaat 28321 cgatgctcgg aaaaagaatg gatttgattg gcgttccaga agcacaatgg ggtaaaataa 28381 gagaagaatt tttagaagat catcagcagg aaaatgaagg atcaaatgaa ccggctgaag 28441 aagacccgct tattgccgaa gcgaaaaagc ttgttggagc ggatttaatt gaaataaaag 28501 actaacaaaa tgaaagagag tgaatgctat gcgtggcgga atgggtaata tgcaaaaaat 28561 gatgaaacaa atgcaaaaaa tgcaaaagga catggcgaag gctcaagaag agcttgcaga 28621 aaaggttgtt gaaggaactg caggcggcgg tatggtaaca gtaaaagcaa acggccaaaa 28681 agaaatcctg gatgttatca tcaaagaaga agtcgttgat cctgaagata ttgatatgct 28741 tcaagattta gtgcttgctg caacgaatga agctttgaaa aaagttgacg aaatcacaaa 28801 cgaaacaatg ggtcaattta caaagggaat gaacatgcca ggtttattct agggggataa 28861 aagaacatgc aatatcctga accaatatca aagctgattg acagctttat gaaattgcca 28921 gggatcggac cgaaaacagc ggttcgtctg gctttttttg ttctaggtat gaaagaagat 28981 gtagtattag attttgcgaa agcattagta aatgcgaaac gcaacctgac atattgttca 29041 gtttgcgggc atattacaga tcaggaccct tgctatatat gtgaagatac gcgcagggat 29101 aagtctgtta tctgtgttgt gcaagaccct aaagacgtta tcgctatgga gaaaatgaag 29161 gaatacaacg gacagtatca cgttcttcac ggcgctattt ctccaatgga cggcatcgga 29221 ccggaggata ttaaaatacc agaattgtta aaacgattac aggatgatca agtgacagaa 29281 gtgatcctcg cgacaaaccc taatatagaa ggggaagcaa cagcgatgta tatatcaagg 29341 ctcctcaagc cgtctggtat taagctctcc cgtattgccc acggactgcc cgtcggcggt 29401 gatttggaat atgctgatga ggtcactctt tctaaagcac ttgaaggaag acgtgaattg 29461 taaggaggaa aaagcgatcc atgggttttc ttcgcaagaa aacattaaga agagagtttg 29521 atgaaaaact aaccgagcag ctttttaagc aaaaggaaga gtggaacagg caaaaaaagc 29581 tggttgaaaa aagcttagaa ccgtctgctg aagtgttata cgaactgaaa gtagctgaag 29641 cgaagtattt tttttactta agggaagcga agcagcgaaa tttaaaaatc agccggtgga 29701 agtaagtggt ctaaactcct ggatcttctc ataagcttgt actagaacaa gcgaaggaga 29761 tgagaagatt catggagcct atttttatta ttgggattat tttaggactg gttattcttc 29821 tttttttatc aggttcagca gcgaagcctt taaagtggat tggcatcaca gctgttaaat 29881 ttgtggcagg tgctttgctg ctggtttgtg taaatatgtt tggcggcagt cttggcattc 29941 atgtgccgat taatctggtt acaacagcta tcagcggaat tttaggaata cccggaatag 30001 ctgcgttagt cgtcattaag caatttatca tttaattgat attatgtatt gacttagaca 30061 actgaaggtg ttattctaat atacgtcgct gatgacgaac agcttttttg aaaagaaaat 30121 gctaaaaagt tgttgacagt agcggcggta aatgttatga taataaagtc gcttaaacga 30181 gcggtaaaca aagttctttg aaaactaaac aagacaaaac gtacctgtta attcattttt 30241 ataaatcgca cagcaatgtg cgtagtcagt caaactactt tatcggagag tttgatcctg 30301 gctcaggacg aacgctggcg gcgtgcctaa tacatgcaag tcgagcggac agatgggagc 30361 ttgctccctg atgttagcgg cggacgggtg agtaacacgt gggtaacctg cctgtaagac 30421 tgggataact ccgggaaacc ggggctaata ccggatggtt gtttgaaccg catggttcaa 30481 acataaaagg tggcttcggc taccacttac agatggaccc gcggcgcatt agctagttgg 30541 tgaggtaacg gctcaccaag gcgacgatgc gtagccgacc tgagagggtg atcggccaca 30601 ctgggactga gacacggccc agactcctac gggaggcagc agtagggaat cttccgcaat 30661 ggacgaaagt ctgacggagc aacgccgcgt gagtgatgaa ggttttcgga tcgtaaagct 30721 ctgttgttag ggaagaacaa gtaccgttcg aatagggcgg taccttgacg gtacctaacc 30781 agaaagccac ggctaactac gtgccagcag ccgcggtaat acgtaggtgg caagcgttgt 30841 ccggaattat tgggcgtaaa gggctcgcag gcggtttctt aagtctgatg tgaaagcccc 30901 cggctcaacc ggggagggtc attggaaact ggggaacttg agtgcagaag aggagagtgg 30961 aattccacgt gtagcggtga aatgcgtaga gatgtggagg aacaccagtg gcgaaggcga 31021 ctctctggtc tgtaactgac gctgaggagc gaaagcgtgg ggagcgaaca ggattagata 31081 ccctggtagt ccacgccgta aacgatgagt gctaagtgtt agggggtttc cgccccttag 31141 tgctgcagct aacgcattaa gcactccgcc tggggagtac ggtcgcaaga ctgaaactca 31201 aaggaattga cgggggcccg cacaagcggt ggagcatgtg gtttaattcg aagcaacgcg 31261 aagaacctta ccaggtcttg acatcctctg acaatcctag agataggacg tccccttcgg 31321 gggcagagtg acaggtggtg catggttgtc gtcagctcgt gtcgtgagat gttgggttaa 31381 gtcccgcaac gagcgcaacc cttgatctta gttgccagca ttcagttggg cactctaagg 31441 tgactgccgg tgacaaaccg gaggaaggtg gggatgacgt caaatcatca tgccccttat 31501 gacctgggct acacacgtgc tacaatggac agaacaaagg gcagcgaaac cgcgaggtta 31561 agccaatccc acaaatctgt tctcagttcg gatcgcagtc tgcaactcga ctgcgtgaag 31621 ctggaatcgc tagtaatcgc ggatcagcat gccgcggtga atacgttccc gggccttgta 31681 cacaccgccc gtcacaccac gagagtttgt aacacccgaa gtcggtgagg taacctttta 31741 ggagccagcc gccgaaggtg ggacagatga ttggggtgaa gtcgtaacaa ggtagccgta 31801 tcggaaggtg cggctggatc acctcctttc taaggatatt ttacggaata taagaccttg 31861 ggtcttataa acagaacgtt ccctgtcttg tttagttttg aaggaacttt gttccttgaa 31921 taagttaaga tgggcctgta gctcagctgg ttagagcgca cgcctgataa gcgtgaggtc 31981 ggtggttcga gtccactcag gcccaccatc ttatataacg gggccttagc tcagctggga 32041 gagcgcctgc tttgcacgca ggaggtcagc ggttcgatcc cgctaggctc caccaacgtg 32101 ttctttgaaa actagataac agtagacatc acattcaatt agtaacacaa gatatcacat 32161 agtgattctt tttaacggtt aagttagaaa gggcgcacgg tggatgcctt ggcactagga 32221 gccgatgaag gacgggacga acaccgatat gcttcgggga gctgtaagca agctttgatc 32281 cggagatttc cgaatgggga aacccaccac tcgtaatgga gtggtatcca tatctgaatt 32341 cataggatat gagaaggcag acccggggaa ctgaaacatc taagtacccg gaggaagaga 32401 aagcaaatgc gattccctga gtagcggcga gcgaaacggg attagcccaa accaagaggc 32461 ttgcctcttg gggttgtagg acactctgta cggagttaca aaggaacgag gtagatgaag 32521 aggtctggaa aggcccgcca taggaggtaa cagccctgta gtcaaaactt cgttctctcc 32581 tgagtggatc ctgagtacgg cggaacacgt gaaattccgt cggaatccgg gaggaccatc 32641 tcccaaggct aaatactccc tagtgaccga tagtgaacca gtaccgtgag ggaaaggtga 32701 aaagcacccc ggaaggggag tgaaagagat cctgaaaccg tgtgcctaca agtagtcaga 32761 gcccgttaac gggtgatggc gtgccttttg tagaatgaac cggcgagtta cgatcccgtg 32821 caaggttaag cagaagatgc ggagccgcag cgaaagcgag tctgaatagg gcgcatgagt 32881 acgtggtcgt agacccgaaa ccaggtgatc tacccatgtc cagggtgaag ttcaggtaac 32941 actgaatgga ggcccgaacc cacgcacgtt gaaaagtgcg gggatgaggt gtgggtaggg 33001 gtgaaatgcc aatcgaacct ggagatagct ggttctctcc gaaatagctt tagggctagc 33061 ctcaaggtaa gagtcttgga ggtagagcac tgattggact aggggcccct accgggttac 33121 cgaattcagt caaactccga atgccaatga cttatccttg ggagtcagac tgcgagtgat 33181 aagatccgta gtcgaaaggg aaacagccca gaccgccagc taaggtccca aagtatacgt 33241 taagtggaaa aggatgtgga gttgcttaga caaccaggat gttggcttag aagcagccac 33301 catttaaaga gtgcgtaata gctcactggt cgagtgactc tgcgccgaaa atgtaccggg 33361 gctaaacgta tcaccgaagc tgcggactgt tcttcgaaca gtggtaggag agcgttctaa 33421 gggctgtgaa gccagaccgg aaggactggt ggagcgctta gaagtgagaa tgccggtatg 33481 agtagcgaaa gaggggtgag aatcccctcc accgaatgcc taaggtttcc tgaggaaggc 33541 tcgtccgctc agggttagtc gggacctaag ccgaggccga aaggcgtagg cgatggacaa 33601 caggttgata ttcctgtacc acctcctcac catttgagca atggggggac gcaggaggat 33661 agggtaagcg cggtattgga tatccgcgtc caagcagtta ggctgggaaa taggcaaatc 33721 cgtttcccat aaggctgagc tgtgatggcg agcgaaatat agtagcgaag ttcctgattc 33781 cacactgcca agaaaagcct ctagcgaggt gagaggtgcc cgtaccgcaa accgacacag 33841 gtaggcgagg agagaatcct aaggtgatcg agagaactct cgttaaggaa ctcggcaaaa 33901 tgaccccgta acttcgggag aaggggtgct ctgttagggt gcaagcccga gagagccgca 33961 gtgaataggc ccaggcgact gtttagcaaa aacacaggtc tctgcgaagc cgtaaggcga 34021 agtatagggg ctgacgcctg cccggtgctg gaaggttaag aggagcgctt agcgtaagcg 34081 aaggtgcgaa ttgaagcccc agtaaacggc ggccgtaact ataacggtcc taaggtagcg 34141 aaattccttg tcgggtaagt tccgacccgc acgaaaggcg caacgatctg ggcactgtct 34201 caacgagaga ctcggtgaaa ttatagtacc tgtgaagatg caggttaccc gcgacaggac 34261 ggaaagaccc cgtggagctt tactgcagcc tgatattgaa tgttggtaca gcttgtacag 34321 gataggtagg agccttggaa accggagcgc cagcttcggt ggaggcatcg gtgggatact 34381 accctggctg tattgacctt ctaacccgcc gcccttatcg ggcggggaga cagtgtcagg 34441 tgggcagttt gactggggcg gtcgcctcct aaaaggtaac ggaggcgccc aaaggttccc 34501 tcagaatggt tggaaatcat tcgcagagtg taaaggcaca agggagcttg actgcgagac 34561 ctacaagtcg agcagggacg aaagtcgggc ttagtgatcc ggtggttccg catggaaggg 34621 ccatcgctca acggataaaa gctaccccgg ggataacagg cttatctccc ccaagagtcc 34681 acatcgacgg ggaggtttgg cacctcgatg tcggctcatc gcatcctggg gctgtagtca 34741 gtcccaaggg ttgggctgtt cgcccattaa agcggtacgc gagctgggtt cagaacgtcg 34801 tgagacagtt cggtccctat ccgtcgcggg cgcaggaaat ttgagaggag ctgtccttag 34861 tacgagagga ccgggatgga cgcaccgctg gtgtaccagt tgttctgcca agggcatcgc 34921 tgggtagcta tgtgcggacg ggataagtgc tgaaagcatc taagcatgaa gcccccctca 34981 agatgagatt tcccattccg caaggaagta agatccctga aagatgatca ggttgatagg 35041 tctgaggtgg aagtgtggcg acacatggag ctgacagata ctaatcgatc gaggacttaa 35101 ccacattttg aatgatgtca cacctgttat ctagttttga gagaacacct ctctaaaggc 35161 ggaaggtaag gaaactccgc taagggctct cacatcctgt gagaaacgcc cagtaccttc 35221 atcctgaagg catttgtttg gtggcgatag cgaagaggtc acacccgttc ccataccgaa 35281 cacggaagtt aagctcttca gcgccgatgg tagtcggggg tttccccctg tgagagtagg 35341 acgccgccaa gcaagcttaa acccagctta atgagctggg ttttttgttt actcaagatc 35401 gagaaaatca aacaaataca aacaccgagg gcttatatag cccatatact gatttaaagt 35461 ttcaaaaagg tctaaatagt gtatacaata tccgttttaa ggggaggcta actgtacgga 35521 ggtggagaag atggacgaaa cagttaaact taatcataca tgtgtgattt gtgatcaaga 35581 gaagaataga ggcattcatc tttatacgaa attcatatgc ttagattgtg agagaaaagt 35641 aatttctaca tcaacttctg atcctgacta tgcgttttac gtaaaaaaac taaagagcat 35701 tcatacaccg ccattatatt catagacctg aaaaggtctt tttttgtact cttaataata 35761 aaaagaagat gaaacttgtt taaggattga acgtagtaga taataatatt aaaactgagt 35821 atagacacag gagtcgatta tctcatgcag agattttttc actttttggt gtggagttta 35881 actagcagtg cgacttttgt tttcattgga atattgagct tttttggttt aaaccagtcg 35941 atttttttat ctattgttta tgggcttgct tctggagcag ccgtatatat agctggcatc 36001 tggaatgcaa gacggttatt tcttaaaaag catgaattga caggaagaga gtatgcttac 36061 attaagaaaa acttagagga agcaaggcag aaaatggtcc gtcttaggaa agccttgttt 36121 caggctaaaa gcattcaaat gtttaagcaa aatgcagaaa tgctaaggat tgtgagaagg 36181 atttatctcc tcaccaaaaa agagccaaag cggttttatc aggcagaacg atttttttat 36241 caaactctcg attcggttgt tgaattgaca gagaagtatg cttttctatc atctcaccca 36301 aaaaaaagca aagaactgtc gatgtcgtta agtgagacac gcatcactct tactgaattg 36361 accaagcgtt tagaggaaga tttaactcaa gcaatgggtg atgaaattga cgagttgcag 36421 tttgaattag acgcagcaaa acattcatta aagaaataag ggaagagggt aagagcgatg 36481 aaccgagacc aaagcgacct tcatatagat gaattattgg cagatccttt tggtggtaac 36541 atagagatac caggttcgga ggctgtaaaa gcagagaaag agcaagtacg gcttgttgat 36601 gttcttcctg aggaaaacaa ggaaaaagca attcagcttg ctggacagat tgatcataaa 36661 aatatgcaaa gcattgtctt atacggttca caagctcaat ctaaactgct gaacttttct 36721 catgatatga ttaatcatgt tcaaaagaag gatgtcgggg agattggcga aatacttgga 36781 gagctgatga aaaagctgga gcaagtaaat cctgatgatc tccaatctaa gaaaaagggt 36841 tttttggcac gcatgtttgg aagagtatca agttctcttc aagaggtgct gtctaaatac 36901 caaaagacca gtgtgcagat agacagaatc agcttgaagc tggagcactc taaaaatgct 36961 ttaatcagtg acaacaagct gttagagcag ttatatgaaa aaaataaaga atatttcgca 37021 gcgctgaatg tttatattgc tgcaggagaa ctgaagctgg aggaattaaa aacaaaaacg 37081 attcctgaac tgaagcaaca ggctgaatcg agtgatcata accaaatggc cgttcaagag 37141 gtgaatgatt taattcaatt tgctgaccgg ttagataaaa gggtgcatga tttgctgctg 37201 agcaggcaaa ttacaatcca aagtgcaccg caaatcaggc tgattcaaaa tacaaaccaa 37261 gcgttagctg aaaagattca gtcatccatt gtgacagcga ttccgttatg gaaaaatcaa 37321 gttgccattg cactgacgct tttaaggcag cgcaatgcag tggatgcaca gcagaaagta 37381 tctgatacaa ccaatgagct tttgctgaaa aatgcggagc ttttaaaaac caatacaatt 37441 gaaactgcac gggcaaatga aagaggcctt gttgatatag ataccttgaa gaaggtgcag 37501 gaaagcttaa taagcacgct tgaagaaaca ctgactatac aagaagaagg acgaatcaaa 37561 cgccgtcagg cagaagaaga gctcatgatg atggaaggcg acctgaagca aaagctgatt 37621 acaataaagg aaagatgatt accagtaagt ctggctttaa gttctgtcag aggcacgata 37681 taataaggtg taagaagaca cattcaaagg attgttttca tgaacacacc tttatataaa 37741 gcattaattc aacatgcgag aagaaattct cattcatttc atgttccggg acatcacaat 37801 ggagatgtct tttttgatga cgctaagtca atattcgatc cgcttctcac cattgatgta 37861 actgaactgg caggactgga tgatctccat catccttctg gggtgattaa ggaagctcag 37921 gagcttgcca gtcaattata tggatcggcg gaaagttttt ttctggtaaa tggtacgact 37981 gtcggaaact tagcgatgat tttatctgtt tgtgaacctg gtgatacaat tctggttcaa 38041 agaaactgtc ataaatctgt atttcatgct gttgatttgt ccggtgctga gccggtttat 38101 cttgcacctg acgttgattc agcgatgcat gtgcctacgc atgttccgct tggaacaatt 38161 aaagaggccc tggaagcata tccagatgcg aaaggcttgg tactgaccaa tccgacatat 38221 tacggacata gtgctgattt gactgagatc attactgaag cccatcatta cgggattcct 38281 gttttggtcg atgaagcgca tggcgcacat tttattttag gtgagccttt tccggtctca 38341 gctttaaaaa tgggggcaga tattgttgtt cagtcggccc acaaaacgtt gccagccatg 38401 acgatgggtt cttatttgca tctcaacagc agctgcagga ttaacaggga tcgggtggca 38461 gagtatttaa accgattaca aagcagcagc ccgtcttatc cgattatggc ttcgttagat 38521 attgcccgcg cttatgtaca gcatattata gaagaacaaa agctttctga cattctgcag 38581 cggatagaaa cacttaaaca aacgtttgat tcacttacaa atgcagaagc tgttaaccct 38641 gctaatccac tgatcatcac ggatccgcta aagctcacaa ttcgttcaaa acgcgggcat 38701 tctggctata cgctgcaaag cattttagag cgtgccaaca tattcactga gcttgctgat 38761 gaaaatcaag ttctgctcgt tctcccattg ggaggaaaac ggagaataaa cgctgaaatc 38821 attagaagca tcgatgaaga gattgagaaa acgcctccgg atcagacgtt tgtttctgca 38881 gaatggggtg tgcagcctgt tactgtcttg ccttatccaa aaaaggtctt acattcgttt 38941 aagaaagaat atgtgagctt tgaggaagca gctggccggc ttaatgcaga agatatcatc 39001 ccttatcctc cgggtatccc gatgattatg gcgggagaaa gaataacaaa agaaagtgtg 39061 caaaagctca gccgcttgat cagcatgaaa acgcatgttc aagggaatat gaaaatcaaa 39121 gagaaacaac tacttgttta tatagaagag gagaaatcat gagcggttta tttattacat 39181 tcgaaggtcc tgaaggtgca gggaaaacga ctgttctgca ggagatcaaa aacatactga 39241 cagcagaagg ccttcaggtt atggcaactc gagagccagg cggaatagat attgcagaac 39301 aaattagaga ggttattctg aatgagaaca atatattaat ggacccaaaa acagaagctc 39361 tcttatatgc ggctgcaaga cgccagcatt tagttgaaaa agtaaaacct gctttagaac 39421 aggggtttat cgttctttgc gacagattca tagacagttc tcttgcgtat caaggatatg 39481 caagagggct tggaattgat gaggttctgt ccattaatga atttgccatt ggagatatga 39541 tgccccatgt aacggtttat ttttcaattg atccggaaga aggactgaag cgtatttacg 39601 caaacggctc acgggagaaa aacaggctcg atttagaaaa actggacttt catacaaaag 39661 tacaagaagg ttatcaagag ctgatgaagc gatttccgga aagatttcat tcagttgatg 39721 ccgggcaatc caaagacctc gtcgttcagg atgttctaaa ggtgatcgat gaagcgttga 39781 aaaaaattca attgtgacct gtttcccaat agttgatata ataatgtaaa cgagatcacg 39841 ttgtttccaa tctaaaggag gccttcacag atgaaattga tagtggcagt tgtacaagat 39901 caggacagca acagactttt gaaaacctta acggatcaca acttcagagt cacaaagctt 39961 gcaacgacag gaggatttct taaatcaggc aatacaacgt ttatgatcgg tgtcgaggat 40021 atacgcgtca ataaagcgtt gagtctcatt aaagaaaacg ggcagaaacg tgatcagatg 40081 attgcccctg tatctccaat gggtggaaat gctgattcct atgtccctta tccagtcgaa 40141 gttgaagttg gcggagcgac agtatttgtc cttccagtcg atgaatttca tcaattttaa 40201 ggatctgaaa ctgtgaaaat taataaagat atacgtacat ttatagataa taagcagatt 40261 ccctctgtga aaacatctga gatcacagca tcgtttaaaa catcaatgga aaaccaaagc 40321 agcaaaatga agcttgatca gcttaccagg ctgttatctg atatagaagc atttggaaaa 40381 aggctaacga aatctcggaa ttttaaagac ttagcgagat ttaaaggact tgtgaaacgt 40441 tttgtcaaag aagctgtgga cagcggtctt tcacatgaaa catcgaaaag ctttgacctt 40501 tacgggaaca gcagaacgct gggacttgtg aaagaaatag atgacaaatt gatacagctt 40561 acggaagaga tgatggatca ggaaaaaccg gcaattgatt tgctggagcg tattggcgaa 40621 ataaaaggtt tattaattaa cctttacaca tagagagtga tacaatggca atatcctgga 40681 aggaaatgaa cgagcttcag cccagagtga tgaagctttt atataatagt attgagaagg 40741 acagactatc acacgcttat ttgtttgagg ggaaaaaagg aacaggcaag cttgatgccg 40801 cgctgcttct tgcaaaaagc ttcttttgtc tggagggtgg cgcggagcct tgtgagagct 40861 gccgaaactg taaacggata gagtcaggga accatcctga tctccatctt gttcagcctg 40921 atggcttatc aatcaaaaag gcgcaaattc aagcgctcca agaagagttt tctaagacag 40981 gacttgaatc gcataaaaag ctgtatatta tttcgcacgc agatcaaatg acagcaaatg 41041 cggcgaacag cctgctgaaa tttttagaag aaccgaacaa agacacaatg gccgtcctca 41101 tcactgagca gccccaaagg ttattggata ccatcatttc aagatgccaa acccttcctt 41161 ttcagccttt gcagccgaaa gcaattgaag acagactgat cgaacaggac gtctcgcctc 41221 atatggcaag gcttctggcc aacatgacta ataatgtagc agaagcagtc gaattaagtc 41281 gaaatgatga gtttgcagag tctagagcga aagtgataaa attgtatgaa gtcctacacc 41341 agcggaaagg acatgctttt ttctttattc aagatcaatg gatgcccttt ttcaaagaaa 41401 aaacccatca agaaatgggt cttgatatgc tcttattgat atatcgtgat gtgttgtcca 41461 tccaaatagg aaatgaagat aaattgattt atcaagactt attccaatca ataaaacagc 41521 atgcgctaca atcaacacaa caaagcgtta cgaatcagat acttgctgtt ttagaagcaa 41581 agaaacggct tcattccaat gtgaatgtac aaggattaat ggagcacttg gtgttaatgt 41641 tgcaggaggg ataagcttgt acaatgtaat tggtgtccgc tttaagaaag cgggtaaaat 41701 atattatttt gatccgaatg gatttcatat agaacatgac agctgcgtaa ttgtagaaac 41761 tgtcagaggc gttgagtacg gccaggtcgt aattgcaaat aaacaggtgg atgagcatga 41821 tgtggtgctt ccccttcgaa aagtgatacg tgtggcagac gatcgcgatc ttctcattgt 41881 agaagaaaat aaacaggaag cactatcagc atttgatatc tgccaaaaga aagtgattga 41941 gcatggcttg gatatgaagc tggtcgatgt tgaattcacg tttgatcgca ataaagtcat 42001 tttttacttc actgctgacg gccgagtcga ctttagagag cttgtaaagg atttggcttc 42061 tatctttaag acaagaattg agctgcgcca aatcggagtg agggatgagg caaaaatgct 42121 cggaggaatc ggtccttgcg gaagaatgct ttgctgttca acgtttcttg gagattttga 42181 acccgtttcc attaaaatgg ccaaggatca gaacttgtct ttaaatccta cgaagatttc 42241 gggtctttgc ggacgattga tgtgctgtct aaaatatgag aacgatgagt atgagacggc 42301 aaaagaacag cttccggata taggagaaat gattacgaca gcaaacggtc ccgcgaaggt 42361 cgtcggacta aatattctgg aacgggtgct tcaggtggaa ctgataaacc gtgaaaaagt 42421 gatagaatat acttgggaag agctcttgga agagggcgtc gtatccgcac aaaccacaga 42481 ttaacgaggt gtggaacctt ggataaaaaa gagttatttg atacagtcat taacttagaa 42541 gaacaaattg gctcactgta ccggcagctg ggggatttga agcagcatat cggtgagatg 42601 attgaggaaa atcatcattt acagcttgaa aacaagcatt tgcgcaaacg gctggacgat 42661 acgacgcagc agattgaaaa gttcaaagct gataaaaaag aatcaaaaac acagaagaca 42721 gagcaaactg atatagggga aggatatgat aatctggcac gtctgtatca agaaggattt 42781 catatctgca atgtccacta tggaagtgtt cgaaaagagg attgtctttt ctgtctgtca 42841 ttcttaaata aaaaataggg aaaaggcttc cgcataagac gggagccttt ttcaaaggta 42901 ctgaaaggat aagaagatgg tttcattaca tgatgatgaa agattagatt atttgctggc 42961 agaggacatg aaaatcatac aaagcccaac agtgtttgct ttttcgttgg acgctgtgct 43021 tctgtccaaa tttgcgtacg ttccgattca aaaagggaaa attgttgatt tatgcaccgg 43081 caatggtatt gtgccgctgc tgctcagtac aagatcaaaa gcagacattc tgggagtcga 43141 aattcaagaa agactgcatg atatggctgt tcgcagcgtg gagtataata agttggacga 43201 tcagatccag atcatacatg atgacctgaa aaacatgccg gagaaacttg gacataatcg 43261 atatgatgtt gtcacctgca atccgccgta ttttaaaacg ccgaaacaaa ctgaacaaaa 43321 catgaacgag catctccgaa tcgcaagaca tgaaatccac tgcacgctgg aggatgtcat 43381 ttcagtcagc agcaagctgc tcaagcaagg gggaaaagca gctcttgttc accggccggg 43441 aaggcttctg gagatttttg aactgatgaa ggcttatcaa atcgagccga aacgtgtaca 43501 atttgtctat ccgaagcaag ggaaagaagc caataccatt ttggttgaag gtatcaaagg 43561 cgggcgcccg gatttgaaaa ttcttcctcc cttattcgta tatgatgaac aaaatgaata 43621 tacaaaagaa atcaggacca ttttatatgg agacaaataa ccatttcttc tacgtcgtga 43681 aatgtaagga caatagctgg tatgccgggt ataccaacga tctgcataaa cgagtgaaaa 43741 cgcacaatga tggaaagggc gcaaagtaca caaaagtaag acgtccggtt gaattaattt 43801 ttgccgagag cttttcaaca aagcgggaag ctatgcaggc ggaatattat ttcaaaaaac 43861 taactcggaa gaaaaaagag ctttatatag aagaaaagcg gaacagcaag gaggctgtat 43921 atgttaaggc gccaaatgag ctttaatgga aagtcggaca tggggattct ttacttggtc 43981 ccaaccccaa tcggaaattt agaggatatg acattccggg cgatcgacac gctgaaatca 44041 gtggatgcga ttgctgcgga agatacgagg caaacgaaaa agctttgtca tgtatatgaa 44101 attgaaacac cgctcgtcag ctatcacgaa cacaataaag aaagcagtgg gcacaaaatt 44161 attgaatggc tgaaatcggg aaaaaacatt gctcttgtca gtgatgccgg tctgccgacg 44221 atttctgatc ccggagcgga aattgtaaag gattttacgg atataggcgg ttatgttgtt 44281 ccgttgccgg gagcaaatgc tgcattaaca gctcttattg cttcaggtat tgtaccgcag 44341 ccttttttct tttacggttt tctcaacaga cagaaaaaag aaaagaagaa ggagcttgaa 44401 gcccttaaaa aacggcagga aacgatcatt ttttatgaag cgccccacag attgaaggaa 44461 accttgtcag cgatggcaga gatattagga gatcgggaaa ttgctgtaac acgtgaactc 44521 actaagaaat atgaagagtt tatccgagga accatatctg aggtcattgg atgggcaaac 44581 gaggatcaga tacgcggcga gttttgtctt gtcgtagaag gaagtaataa tgaagaggta 44641 gatgaggaag aacaatggtg ggaaaccctc actgcgaaag aacatgtcga gcattacatt 44701 tcgaaaggcg ctacgtctaa agaagctatt aaaaaagcag cagtcgatcg caatgtacca 44761 aagcgtgaag tgtacgatgc ttaccatatt aagcaataaa aaaacgttct tgtgtcataa 44821 caagaacgtt ttttgtacaa gaaatgatta tttaaggttt tgaagctggt tttggatttc 44881 gctgatgatt tgctcagcgc cttctttact aagaaccaat ttaccgcctg caagtttaag 44941 gttatcatca gaaacttcac cagttacttg gcaagtcatg tttggtttat attttttaag 45001 gatgattttt tcatcatcaa catagatttc aagagcatct ttttctgcga ttccaagagt 45061 acgacgcagt tcgataggaa taactacacg tcctaattca tcaactttac gtacaatacc 45121 agtagatttc ataaacattc tcctcccaag agatacttat ttgtttaaat tatatttttc 45181 ttcgtcatta ttcgacaaaa tccttacctt catagcataa caaggtttcc aataatcgtc 45241 aatcattttg tttactattg attgtaagaa ttagttctta tagtcagtaa tgtcttggaa 45301 actaccgaaa taacagcatt ttataaatat ttaataaagc tattatccta ctaaaaatcc 45361 ttttaaatca agactttcga accaaagttt tttatttcat ttgattatat acgacaaaat 45421 tcgacacgaa cagacttttt ttattttcat taaagatttt taattttaat tattcttttt 45481 cagggcgtat gtatatattc ttgatcttaa aggctaagat ggtatcatag ataaaggata 45541 aatataaata atattcatat atgatttgca cttatcgccg ctctcgtcct ttgggcggga 45601 gctttttgac attctgatta ggaggtttca agatgccgca agaaaacaat acattttaca 45661 ttacaacacc gatttattat ccgagcggaa aattacatat cggccatgca tatacgacag 45721 tcgcaggaga tgcaatggca cgttacaaaa gattaaaagg gttcgatgtt cgctatttaa 45781 cgggaacgga cgagcatgga caaaagatcc agcaaaaagc tgaacaggaa aacattacac 45841 ctcaggagta tgtggatcgc gcagcggcag atattcaaaa actgtggaag cagcttgaaa 45901 tctcaaacga cgactttatc cgcacgacag aaaaacggca taaagttgtc attgaaaaag 45961 tgtttcaaaa gcttcttgat aacggggaca tctatcttga tgagtatgaa ggctggtaca 46021 gcatccctga tgaaacgttc tacacggaaa ctcagctcgt tgatattgag cggaatgaaa 46081 agggagaggt catcggcgga aaaagccctg acagcggtca cccagttgaa ttgatcaaag 46141 aggaatctta tttcttccgc atggggaaat acgcggatcg tcttctgaaa tactatgaag 46201 aaaacccgac attcattcag ccagaatcac gcaaaaacga aatgattaat aactttatca 46261 aacctggact tgaggatttg gcagtatcac gtaccacttt tgattggggc gtgaaggtgc 46321 cggaaaatcc aaagcatgtt gtatatgttt ggattgacgc actatttaac tatttaacgg 46381 cactcggtta tgatacagaa aatgatgagc tttatcaaaa atattggcct gccgatgttc 46441 atttagtcgg taaggagatt gtacgattcc atactattta ctggccaatt atgctgatgg 46501 cgctggatct tccgctgcca aagcaagtat tcgcgcatgg ctggcttttg atgaaagacg 46561 gaaaaatgtc gaaatcaaaa ggaaacgttg tagatccggt tacattaatt gaacgctatg 46621 gtttagacga acttcgctat tacttgcttc gcgaagtgcc gttcggatca gacggtgttt 46681 tcacgccgga aggatttgtt gagcgaatca actatgattt agcgaatgat ttaggaaatc 46741 tattgaatcg tactgttgcg atgattaata agtattttga cggacaaatc ggttcttaca 46801 aaggtgctgt tacggaattt gaccatacgc tcacttctgt tgctgaagaa acagtgaaag 46861 cttatgagaa agcaatggaa aatatggagt tctcggtagc actttcgact ttatggcagc 46921 tcatcagccg cacaaacaaa tacattgatg agacagctcc atgggtgctt gcgaaagatc 46981 cggcaaaaga agaagaattg cgatcagtta tgtatcatct cgctgaatca ttgcgtattt 47041 cagcggtact gcttcagcca ttcttaacaa aaacacctga aaaaatgttc gagcagctgg 47101 gcattactga tgaatcttta aaagcttggg acagcattac agctttcggc cagctgaaag 47161 atacaaaagt acaaaaaggc gagccattgt tccctcgttt agaggcagaa gaagaaattg 47221 cttacatcaa agggaaaatg caaggttcag caccagcgaa agaagaaaca aaagaagaag 47281 agcctcaaga ggtcgatcgt ttacctgaaa ttacgattga tcaatttatg gatgtagagc 47341 ttcgcgtagc tgaggtcatt gaggcagagc cagtgaaaaa agcagaccgt ttattgaagc 47401 tgcagcttga tcttggtttt gaaaagcgcc aagtggtatc cggcattgcg aagcattata 47461 cgcctgaaga gcttgttgga aaaaaactcg tttgtgtaac aaatctaaaa ccggttaaac 47521 tcagaggaga gctttctcaa ggtatgatcc ttgcaggaga agcagacggc gttttaaagg 47581 tcgtatctat cgatcagtcg ttaccaaaag gcacaagaat taaataatga taaacaaaag 47641 gtgtttcacg tgtaacaatt cgtcgaacac cttttgtgtt tcgacaagaa aggagttttt 47701 cacttatgtt gtttgacact cacgcgcatt taaatgcaga acaatatgat actgatcttg 47761 aagaggttat tgaacgggca aaagctgaaa aagttgaacg aattgtcgta gttggttttg 47821 accgtccgac gattacccgt gcgatggaaa tgattgagga atatgatttt atttatgcag 47881 ccattggctg gcaccctgtt gacgctattg acatgacaga ggaagactta gcgtggatta 47941 aagagctttc tgctcatgag aaagtggtag cgatagggga aatgggactg gattatcatt 48001 gggataaatc acctaaagat attcaaaaag aggtgtttag aaatcaaatc gccttagcga 48061 aagaggtcaa tttgcctatt atcattcata accgtgatgc aacggaggat gtcgtgacca 48121 ttttgaaaga ggaaggcgca gaagctgtgg gcggaatcat gcactgcttt acaggaagtg 48181 cggaagtggc aagagaatgc atgaaaatga atttttattt atcatttggg ggaccggtga 48241 catttaaaaa tgcgaagaaa ccgaaggaag tagtgaagga aattcccaat gaccggctgc 48301 tgattgaaac ggactgcccg tttctcacac cgcacccttt ccgcgggaaa agaaatgagc 48361 caagctatgt gaaatatgtg gcagaacaaa tcgccgaatt aaaagaaatg acctttgaag 48421 agattgcttc catcacgact gaaaatgcga aaagactttt ccgtataaac tgacaaaaaa 48481 cgctagcggg ttttgtaaga gcttgtccct tacagcgttt ttctataaaa gttctacatg 48541 ctttcttctc ctcataggat aggtttgtcg acaagtcttt cttccgtttc tcagtgtatt 48601 tcaggataat gaagaggaca ctgagctttt gggagaaaga gaagggaggg ttgacagcct 48661 tttagatact ctatataatc tctccgagga gaaggaggcg tttttcatca cacaaaaaat 48721 gaaaaagctg ttttccgtaa agcttagcaa aagcaaagtc attctggttg ctgcttgttt 48781 gcttttggca ggaagcggga ctgcgtacgc ggctcatgag ctgacgaaac aatcagtctc 48841 agtttctatc aatggcaaaa agaaacatat acgcacacat gcaaatacag tcggtgatct 48901 tttggagacg cttgatataa agacaagaga cgaagacaag atcacacctg ctaaacagac 48961 aaagataaca gcagacatgg acgttgtgta tgaggctgca aaacctgtga agcttacaat 49021 aaacggggaa gaaaagacgt tatggtcaac agcaaaaacg gtcggtgcat tactggacga 49081 acaagatgtt gatgtgaaag aacaagatca aattgatccc gcaatagata cagatatttc 49141 gaaagacatg aagattaaca tagagcccgc atttcaggtt actgtgaatg atgcagggaa 49201 acaaaagaag atctggacga cttcgactac ggtcgctgac tttttaaaac agcaaaagat 49261 gaacataaaa gacgaagata aaatcaagcc tgcgttagat gcaaagctga cgaaaggaaa 49321 ggctgatatt acaattactc gtatcgaaaa ggtcaccgat gtagttgaag agaagattgc 49381 gttcgatgtg aaaaagcaag aagacgcttc tcttgaaaaa gggaaagaaa aggtcgtcca 49441 aaaaggaaaa gaaggcaagc taaaaaaaca tttcgaagtc gttaaagaaa acggtaaaga 49501 agtgtccaga gagcttgtaa aagaagaaac agctgaacaa agcaaagata aagtgattgc 49561 tgtcggcaca aagcaaagca gtccaaaatt tgaaacggtc agtgcttcag gtgattcaaa 49621 aacagttgtg tcccgcagca atgaatcaac aggcaaagtc atgactgtat catctacggc 49681 ttatacggca agctgcagcg gttgttcagg acatacagcg acaggcgtca atttaaaaaa 49741 taatccgaat gccaaagtca tcgctgtgga tccaaatgtc attccgctag gctccaaagt 49801 ccacgtggaa ggctatggat atgccattgc tgcagatacc ggttcagcga ttaaagggaa 49861 caagatagac gtctttttcc cagagaaatc atcggcgtac cgatggggaa ataaaacagt 49921 caaaattaaa atcttaaatt agtatatact tatgtattca gagggttttg cgccctctgt 49981 ttttttcgtt ataatagaca aagtgcattt tctgcttatt agacgctcga tataagaaaa 50041 agtttcatga atatacaaaa gtttttattt tgtcttggag gaaataatga aaattaaaga 50101 gatcattgtg gtcgaggggc gtgacgatac ggcccgcatc aaattggctg ttgatgcaga 50161 cacaattgaa acaaatggtt cagccatcga tgatcatgtg attgaccaaa tccgtttggc 50221 ccagaagacg agaggcgtca ttattttaac ggatccggac tttccgggag agaagattcg 50281 caaaaccatc tcagaggctg tacccggctg taagcatgca tttttgccaa aacatcttgc 50341 caaacctaaa aacaagcggg gaattggtgt ggagcatgca tcggttgaaa gcattagggc 50401 atgtttagaa aatgtgcatg aggagatgga agcgcagccg agtgacattt cagctgagga 50461 tttgattcat gccggactaa taggcgggcc tgcggccaaa tgccgccggg aacgactggg 50521 tgatctgttg aaaatcggct atacaaatgg caaacagctt caaaaacggc tgcaaatgtt 50581 tcaaattaaa aaaagtgatt ttatgagtgc gctcgatacc gttatgcggg aggaacagaa 50641 tgaataaaga tattgcgaca ccgattagaa cgaaagagat actgaagaaa tacggttttt 50701 cttttaaaaa gagcttagga cagaatttct taattgatac gaacatttta aacagaattg 50761 ttgatcacgc ggaagtgacg gagaaaacag gtgtcattga aatcggcccg ggaatcgggg 50821 ctttaaccga acagcttgcc aagcgggcga aaaaggtcgt ggcatttgag attgaccagc 50881 gattattgcc gattctgaag gatacactgt caccttacga aaatgtcact gtcattcatc 50941 aggacgtgtt aaaggctgat gtcaaatcag tcattgaaga acaatttcaa gattgtgatg 51001 agatcatggt agttgccaac cttccttatt acgtaacaac accgattatc atgaaactgc 51061 ttgaagaaca tcttccgctg aaagggattg tggttatgct gcaaaaagaa gtggctgagc 51121 gcatggcggc tgatccttca tctaaggaat acggctcgct ttcaatcgcg gtgcagtttt 51181 atacagaagc caaaacggtg atgatcgtcc cgaaaaccgt atttgttcct cagcctaatg 51241 tcgattccgc agtcattcgt ctgattctcc gagacggccc ggcagtggac gtggaaaacg 51301 aatccttttt ctttcagctc atcaaggcaa gctttgcaca gcgccgtaaa acgctgctca 51361 ataacttagt taacaatctg cctgaaggaa aagcacaaaa atcaacgatt gaacaagtgc 51421 tcgaagaaac aaatattgac ggtaagcgcc gaggtgaatc cctgtctatt gaggaattcg 51481 cagcgctgtc taacggattg tataaagccc ttttctaaaa gggctttttg ttttgcgcac 51541 cacatggact gccgctacat aggctagaga aggacctttc attcaatgat aagaaaaaac 51601 ttggactcag cgaaaaaagg cgctttctca aggctctttc tttcatgatg aggcttagtc 51661 tatgtgtgga gtgaggaacg tgcaatttca aataggggat atggtagcca gaaaatccta 51721 tcagatggat gttttgtttc gaattatagg aatagagcaa acaagcaaag gaaattcaat 51781 tgccattttg catggagatg aagtcaggct gattgctgat tcggattttt ctgatctggt 51841 ggcagtgaaa aaggatgagc agatgatgcg gaaaaagaaa gatgagagca gaatgaatga 51901 gtcgctcgaa ttgctccgcc aagattataa gctgctcaga gaaaagcagg agtactatgc 51961 gacaagccaa tatcagcatc aggagcatta tttccatatg ccgggcaaag tgcttcatct 52021 ggatggtgac gaagcatatt tgaaaaaatg cctgaatgtc tataaaaaaa ttggagtgcc 52081 ggtctatggc atccattgcc atgaaaagaa aatgtctgct tctattgaag tattgctcga 52141 caaatatcga cctgacatcc tggtgatcac agggcatgat gcgtactcga agcaaaaggg 52201 cggtattgat gatttgaatg cgtacagaca ttctaagcac tttgttgaaa cagttcaaac 52261 agcccgaaaa aagatccctc acttagatca gcttgttatt tttgcggggg cctgccaatc 52321 ccattttgaa tcactcatca gagcgggtgc gaattttgca agttcaccgt caagagtcaa 52381 tattcatgcg cttgatccgg tatatatcgt cgcgaagatc agctttacgc cgtttatgga 52441 acggattaat gtatgggaag tgctccgtaa tacgctgaca agagagaaag ggcttggagg 52501 tattgaaaca agaggagttc tgagaattgg tatgccttat aagtccaatt aacagttgaa 52561 aacctgcata ggagagctat gcgggttttt tattttacat aatgatacat aatttaccga 52621 aacttgcgga acataattga ggaatcatag aattttgtca aaataatttt attgacaacg 52681 tcttattaac gttgatataa tttaaatttt atttgacaaa aatgggctcg tgttgtacaa 52741 taaatgtagt gaggtggatg caatggcgaa gacgttgtcc gatattaaaa gatcgcttga 52801 tgggaattta ggtaaaaggc tgacgttaaa agcaaacggt ggccgccgaa aaacgattga 52861 gcgttcgggc attttagctg agacgtaccc ttctgttttt gtgatacaac tagatcaaga 52921 cgagaactcg tttgaaagag tttcatacag ttatgctgat attttgactg agactgttga 52981 gctgacattt aatgatgacg ccgcaagctc agtggcattt taacgggcag tgaacctttt 53041 gtttactgct ttttgttttg cccttttttg gtttccaata attttaacga aagttccatc 53101 tgatttaaca aaagataaaa cagtcacata ttatcgtgac gtgcacgaat ggctatcact 53161 tctaaaaaag gagttgtttc gtttgggcag acgtcgtgga gttatgtcag atgagtttaa 53221 atatgagctg gctaaagacc ttggttttta tgacacagta aaaaatggag gctggggtga 53281 aattcgggcc cgcgatgccg gtaacatggt gaagcgtgct attgaaatcg ccgaacagca 53341 aatggctcag aatcagaata accgataagg atgtgacccg ggggacgtgc tgttccctgg 53401 tttttttatt ttggatataa atacataatg ggctgaatat ggatatgttc atcctgtact 53461 tcaaatgtga tacaatgttc atacttatgt ttagatggag aagtaggtga aagctatgcg 53521 tattttagaa aaagcgccag ctaagatcaa tctgtcactt gacgtcaccc gaaaacgccc 53581 ggatggctat catgaagtcg aaatgatcat gacgacaatt gatttagctg atcgaattga 53641 attgacggag cttgcagagg atgaagtgag ggtttcctcc cacaaccgat ttgtgcctga 53701 tgaccaaaga aacttagctt atcaggctgc caagctgatc aaggacagat acaacgtgaa 53761 aaagggagtt tccatcatga ttacgaaggt aattccggtg gctgccggtc ttgccggcgg 53821 aagcagtgat gcggcggcga cactcagagg gctgaacaga ctgtggaatt taaatctgtc 53881 cgcggaaacg cttgctgagc ttggagcgga aattggctct gacgtttcat tttgtgtcta 53941 tggcggaact gcattagcaa cagggcgcgg cgagaaaatt aaacatatca gcacgcctcc 54001 gcactgctgg gtcattttag cgaagccgac aatcggtgtt tcaactgctg aagtgtacag 54061 agcgctgaaa ctggatggta tagagcatcc cgatgtacaa ggcatgatcg aggcgataga 54121 agaaaagagt tttcagaaga tgtgcagccg gttaggcaat gtgcttgaat ctgttacact 54181 cgatatgcat cctgaagttg cgatgatcaa aaaccagatg aaacgctttg gtgcagatgc 54241 cgtgttaatg agcgggagcg gcccgacagt gtttggactg gttcagtatg agtcgaaggt 54301 gcagagaatt tataacgggt taagaggctt ctgcgatcaa gtttatgcgg tgagaatgat 54361 cggcgaacag aacgctcttg attaaatccg tatgttaagt tatattgatc ttaaaatatt 54421 cggattttgg gggtgagttc atgaagtttc gtcgcagcgg cagattggtg gacttaacaa 54481 attatttgtt aacccatccg cacgagttaa taccgctaac ctttttctct gagcggtatg 54541 aatctgcaaa atcatcgatc agtgaagatt taacaattat taaacaaacc tttgaacagc 54601 aggggattgg tactttgctt actgttcccg gagctgccgg aggcgttaaa tatattccga 54661 aaatgaagca ggctgaagct gaagagtttg tgcagacact tggacagtcg ctggcaaatc 54721 ctgagcgtat ccttccgggc ggttatgtat atttaacgga tatcttagga aagccatctg 54781 tactctccaa ggtagggaag ctgtttgctt ccgtgtttgc agagcgcgaa attgatgttg 54841 tcatgaccgt tgccacgaaa ggcatccctc ttgcgtacgc agctgcaagc tatttgaatg 54901 tgcctgttgt gatcgttcgt aaagacaata aggtaacaga gggctccaca gtcagcatta 54961 attacgtttc aggctcctca aaccgcattc aaacaatgtc acttgcgaaa agaagcatga 55021 aaacgggttc aaacgtactc attattgatg actttatgaa agcaggcggc accattaatg 55081 gtatgattaa cctgttggat gagtttaacg caaatgtggc gggaatcggc gtcttagttg 55141 aagccgaagg agtagatgaa cgtcttgttg acgaatatat gtcacttctt actctttcaa 55201 ccatcaacat gaaagagaag tccattgaaa ttcagaatgg caattttctg cgttttttta 55261 aagacaatct tttaaagaat ggagagacag aatcatgaca aaagcagtcc acacaaaaca 55321 tgccccagcg gcaatcgggc cttattcaca agggattatc gtcaacaata tgttttacag 55381 ctcaggccaa atccctttga ctccttcagg cgaaatggtg aatggcgata ttaaggagca 55441 gactcatcaa gtattcagca atttaaaggc ggttctggaa gaagcgggtg cttcttttga 55501 aacagttgta aaagcaactg tatttatcgc ggatatggaa cagtttgcgg aagtaaacga 55561 agtgtacgga caatattttg acactcacaa accggcgaga tcttgtgttg aagtcgcgag 55621 actcccgaag gatgcgttag tcgagatcga agttattgca ctggtgaaat aataagaaaa 55681 gtgattctgg gagagccggg atcacttttt tatttacctt atgcccgaaa tgaaagcttt 55741 atgacctaat tgtgtaacta tatcctattt tttcaaaaaa tattttaaaa acgagcagga 55801 tttcagaaaa aatcgtggaa ttgatacact aatgctttta tatagggaaa aggtggtgaa 55861 ctactgtgga agttactgac gtaagattac gccgcgtgaa taccgatggt cgcatgagag 55921 cgattgcatc catcacgctg gatcacgaat ttgttgtaca tgatattcgt gtgattgatg 55981 gaaacaatgg tcttttcgtt gcgatgccga gtaaacgcac ccctgatgga gagttccgcg 56041 atattactca tcctattaat tcaagcacgc gaggaaagat tcaagatgcc gtgttaaatg 56101 agtatcatcg tctgggtgac actgaagcat tagaattcga agaagctgga gcttcttaaa 56161 aaataaccaa aaagcaagga ctgctgaaag ggctgacata agccttttgc cggcggtcct 56221 tttttaattc tgatttttca aacttagttg cactcaatag aaaattcttg cacttcatga 56281 agtctccttg aaatcagaag atatttagga tatatttttc tatggataaa agggatattg 56341 gaggccaata aatggataag cggtttgcag ttgttttagc ggctggacaa ggaacgagaa 56401 tgaaatcgaa gctttataaa gtccttcatc cagtttgcgg taagcctatg gtagagcacg 56461 tcgtggacga agccttaaaa ttatctttat caaagcttgt cacgattgtc ggacatggtg 56521 cggaagaagt gaaaaagcag cttggtgata aaagcgagta cgcgcttcaa gcaaaacagc 56581 ttggcactgc tcatgctgta aaacaggcac agccatttct tgctgacgaa aaaggcgtca 56641 caattgtcat ttgcggagat acgccgcttt tgacagcaga gacgatggaa cagatgctga 56701 aagaacatac acaaagagaa gcgaaagcta cgattttaac tgcggttgca gaagatccaa 56761 ctggatacgg ccgcattatt cgcagcgaaa acggagcggt tcaaaaaata gttgagcata 56821 aggacgcctc tgaagaagaa cgtcttgtaa ctgagatcaa caccggtacg tattgttttg 56881 acaatgaagc gctatttcgg gctattgatc aggtgtctaa tgataatgca caaggcgagt 56941 attatttgcc ggatgtcata gagattctta aaaatgaagg cgaaactgtt gccgcttacc 57001 agactggtaa tttccaagaa acgctcggag ttaatgatag agttgctctt tctcaggcag 57061 aacaatttat gaaagagcgc attaataaac ggcatatgca aaatggcgtg acgttgattg 57121 acccgatgaa tacgtatatt tctcctgacg ctgttatcgg aagcgatact gtgatttacc 57181 ctggaactgt gattaaaggt gaggtgcaaa tcggagaaga tacgattatt ggccctcata 57241 cggagattat gaatagtgcc attggcagcc gtacggttat taaacaatcg gtagtcaatc 57301 acagtaaagt ggggaatgat gtaaacatag gaccttttgc tcacatcaga cctgattctg 57361 tcatcgggaa tgaagtgaag atcgggaatt ttgtagaaat taaaaagact caattcggag 57421 accgaagcaa ggcatctcat ctaagctatg tcggcgatgc tgaggtaggc actgatgtaa 57481 acctgggctg cggttcaatt actgtcaatt atgatggaaa gaataagtat ttgacaaaaa 57541 ttgaagatgg cgcgtttatc ggctgcaatt ccaacttggt tgcccctgtc acagtcggag 57601 aaggcgctta tgtggcggca ggttcaactg ttacggaaga tgtacctgga aaagcacttg 57661 ctattgccag agcgagacaa gtaaataaag acgattatgt gaaaaatatt cataaaaaat 57721 aatcctaaat tcggaggttt atccatgtct aatcaatacg gagataagaa tttaaagatt 57781 ttttctttga attcgaatcc agagcttgca aaagaaatcg cagatatagt tggagttcaa 57841 ttagggaaat gttctgtcac aagatttagt gacggggaag tccaaattaa tatcgaagaa 57901 agtattcgcg gatgtgattg ttacatcatc cagtctacaa gtgaccccgt taacgagcat 57961 attatggaac tgctgattat ggtagatgcg ttaaaacgcg cttctgcaaa aacgattaac 58021 attgttattc cttattacgg ttatgcgcgt caagacagaa aagcaagatc ccgtgagcca 58081 atcacagcta aacttttcgc taacctgctt gaaacagccg gtgcgactcg tgtgattgca 58141 cttgacctgc atgcgccgca aattcaagga ttctttgata taccgattga ccacttaatg 58201 ggtgttccga ttttaggaga atattttgaa ggcaaaaatc ttgaagatat cgtcattgtt 58261 tcaccagacc atggcggtgt gacacgtgcc cgcaaactgg ctgaccgact aaaagcgcca 58321 attgcgatta tcgataaacg ccgtccgcgt ccaaacgtgg cggaagtcat gaatattgta 58381 ggtaacatcg aagggaagac tgctatcctc atcgatgaca ttattgatac tgcaggtacg 58441 attacacttg ctgctaatgc gctcgttgaa aacggagcga aagaagtata tgcatgctgt 58501 acacaccctg tactatcagg ccctgcggtt gaacggatta ataattcaac aattaaagag 58561 cttgttgtga caaacagcat caagcttcct gaagaaaaga aaattgaacg ctttaagcag 58621 ctttcagtcg gaccgcttct ggccgaagcg attattcgcg ttcatgagca gcaatcagtc 58681 agctatctgt tcagctaaac catttttcga ggtttaaatc cttatcgtta tgggtattgt 58741 ttgtaatagg acaactaaaa cgacaagagg atggtgctga atatggcaac tttaacggca 58801 aaagaaagaa cggactttac tcgttcgtct cttcggaata tccgtacttc aggacatgtt 58861 ccaggtatca tatatgggaa ggatacgggt aacaaacctg tgtcattaga cagtgtggag 58921 ctcatcaaaa cgctgaggga cgaaggcaaa aatgcagtca ttacgcttga ggtcagcgga 58981 gaaaaacact cagtcatggt aacagacctg cagacggacc cgctgaaaaa tgaaatcact 59041 catgctgatt ttcaagtagt taatatgagt gaggacattg aagtggaagt tccgattcat 59101 ctgaccggag aagccattgg agtgaaaaac ggaggcgtac tgcagcagcc gttatatgca 59161 cttactgtaa aggccaagcc aaaagccatt ccgcaaacga ttgaggctga tatttcaagc 59221 ctcgatgtaa atgaagtact gacgattgcg gatttgcctg ctggcggtga ctactccttt 59281 aatcatgaat cagatgaggt tgtggcttca atccttcctc cgcagcagca ggaagcagct 59341 gaggtcgatg aagaggaatc tgccgatgct cagcctgaag gtgaaaacga acaataatag 59401 cttaaggcgt aaccctcccg cggttacgtc ttttgtgcta gaatgagaag aattatagcc 59461 cgtttatgaa gacgggagtt atgtgactaa gggaggattc gccatgcttg tgattgccgg 59521 tctcggaaac ccggggaaga actatgaaaa tacacggcat aatgtcggat ttatggtgat 59581 agatcagctt gcaaaggaat ggaatataga gctgaatcaa aataaattta acggattata 59641 cggaaccgga tttgtttccg gcaaaaaggt tctacttgtt aaaccgctta catatatgaa 59701 tttatcagga gaatgtttgc ggcctttaat ggactactat gatgtcgata acgaagattt 59761 gacagtcatt tacgacgacc ttgaccttcc gactggcaag atccgtttaa gaacgaaagg 59821 aagcgccgga gggcacaatg gcatcaaatc actgatccag catcttggaa cgtccgagtt 59881 tgaccgtatc cgcatcggaa tcggccggcc tgtaaacggc atgaaggtcg ttgattatgt 59941 gttaggctcc tttaccaagg aggaggcacc tgagatcgaa gaagcggttg ataaatctgt 60001 gaaggcttgt gaggcttctt tgagtaaacc gtttttagaa gtcatgaacg aatttaacgc 60061 aaaggtataa aatgtaacaa caaagtccat actacaccaa aatgactttt tcatcaggag 60121 gacccttgta tggctttgca ttattattgt cgtcattgcg gagtgaaagt aggcagtctc 60181 gaatcttcaa tggtatcgac agactcactt ggatttcagc acttaacaaa tgaggaaaga 60241 aacgatatga tttcttataa agaaaatgga gatgtccatg ttttgacgat atgtgaagac 60301 tgccaagagg cgcttgaccg aaatccgcat taccacgaat atcacacatt tattcaataa 60361 aaagctttgg tgtagacact agaccaaagc gtttttctgt tctcgcagga aacagagagg 60421 aggggccata tggacaacat tcaaaccttt ataaaagaaa gcgatgactt taaatccatc 60481 atcaacggtt tacacgaggg cctgaaggaa cagctgctcg cgggtctgtc gggttccgcg 60541 cgttctgttt ttacttctgc tctggctaat gaaacgaata agcctatctt tctcatcacc 60601 cataacttat atcaagccca gaaagtaaca gatgatctga cttcacttct agaggatcgg 60661 tctgtccttt tgtaccccgt caatgaactc atttcatcag aaatcgcagt tgcaagccct 60721 gaattgcggg cgcagcgatt agatgtcatt aatagactaa cgaatggaga agcgccaatt 60781 gtcgttgctc cggtagctgc aatcagaaga atgctgccgc ctgttgaggt gtggaaaagc 60841 agccagatgc tcattcaagt aggccatgat attgaacctg accagcttgc ctcacggctg 60901 gtagaggtag ggtatgagcg gtctgatatg gtttctgcgc ccggggaatt cagtattcgc 60961 gggggaatca ttgacattta tccgctgact tcagagaatc cggtgagaat tgaacttttt 61021 gacaccgagg tggattcaat ccgcagcttt aattcagatg atcagcggtc aattgagacc 61081 cttacctcga tcaatatcgg tcccgcgaag gaattaatta tcagaccgga agaaaaagcg 61141 cgggcgatgg agaaaatcga tagtggtctt gccgcgagct tgaaaaaatt aaaggctgac 61201 aaacaaaaag aaatacttca tgcgaatatt tctcacgata aagaacgctt gtctgaaggc 61261 cagacagatc aggagctcgt gaagtatctc tcatatttct atgaaaagcc tgctagttta 61321 ctagattata cacctgataa tacacttctg attttggatg aagtcagtcg gattcatgag 61381 atggaagaac agcttcaaaa agaagaagcg gagtttataa caaatcttct tgaggaaggg 61441 aagattttgc atgacattcg tttgtcattc agcttccaaa aaatagtggc tgagcaaaaa 61501 cggcctctgc tgtactactc tttatttttg cggcatgtac accatacgag cccgcaaaat 61561 atcgtcaatg tgtcaggccg gcaaatgcag agtttccatg gccaaatgaa cgtgcttgcg 61621 ggcgaaatgg agcgttttaa aaaatcaaat ttcactgttg tgttcttagg agcaaacaag 61681 gaacgtacgc agaaattgtc atctgttttg gctgattatg atatcgaggc cgccatgaca 61741 gacagcaaaa aagcgcttgt tcagggacag gtctatatca tggaaggcga gctccaatcg 61801 ggatttgagc tgccgttaat gaagcttgcc gttatcacgg aagaagaact gttcaaaaac 61861 cgtgtaaaga agaagccgcg aaaacagaag cttaccaatg cagagcgcat caaaagctat 61921 tctgagcttc aaattggaga ttatgtcgtt catattaatc acgggatcgg aaaatacctg 61981 gggattgaaa ctcttgaaat caacggcatt cataaagact atttaaatat acattatcag 62041 ggcagtgaca agctttacgt ccctgtagaa caaattgatc aggtccaaaa atatgttggc 62101 tccgaaggaa aagagccaaa gctgtataaa ttaggcggaa gtgaatggaa gcgggtcaag 62161 aaaaaagtag agacatccgt tcaggatatt gctgatgact taattaagct gtatgccgaa 62221 agagaagcga gcaagggcta tgcgttttct cctgaccatg agatgcagcg tgaattcgaa 62281 tcggctttcc cttatcaaga gactgaggat cagctccgtt ctattcacga aatcaaaaaa 62341 gacatggaaa gagaacgtcc gatggaccgc ttgctgtgcg gagatgtggg ctacggtaaa 62401 acagaggttg ccatacgtgc cgcgtttaag gcgatcggtg acggaaagca ggtagctctg 62461 ctcgttccga caaccatttt ggcacagcag cactatgaaa ccataaaaga gcgcttccag 62521 gactatccga ttaatatcgg ccttctcagc aggttcagaa cgagaaaaga agcaaacgaa 62581 acaatcaaag ggctgaaaaa tggaacggtt gatatcgtca tcgggacgca tcggctgcta 62641 tcaaaggatg tcgtgtataa agacttaggg ctcctcatca ttgatgaaga gcagcgtttc 62701 ggtgtaaccc ataaagaaaa gatcaagcaa ataaaagcca atgttgatgt attaacgtta 62761 acagcaacgc cgattccgcg tacgctgcat atgtctatgc ttggcgtaag ggacctttca 62821 gtcatcgaga ctccgccgga aaatcgcttc cccgtacaga cgtatgttgt ggaatataac 62881 ggcgctcttg tcagagaggc gattgaacgt gagcttgcac gcggaggcca ggtctatttc 62941 ttgtacaacc gggtagagga cattgagcgg aaagcggatg aaatttcaat gctagtccct 63001 gacgcgaagg tagcatatgc gcatgggaaa atgacagaaa atgaattaga aaccgttatg 63061 ctaagcttcc ttgaaggaga atcagacgtt ctcgtcagca caaccattat cgaaactggc 63121 gtggacatcc caaacgtcaa tacgctgatc gtatttgacg ccgacaagat gggactttct 63181 cagctttacc agctgcgggg gcgtgtcggc cgttctaacc gtgtggcgta tgcgtacttc 63241 acgtatcgcc gggataaagt gctgacagaa gtggctgaaa aaaggctgca ggctattaaa 63301 gaattcacag agttaggttc cggttttaaa atcgcaatgc gtgacttaac gattcgcgga 63361 gccgggaatc ttcttggtgc ccagcagcat ggcttcatcg attcggtcgg atttgacctc 63421 tattcacaaa tgctgaagga ggccattgag gagcgtaaag gagacacagc gaagacagag 63481 cagtttgaaa cagaaattga tgtcgagctt gatgcgtata ttccggaaac ttatattcaa 63541 gacggcaaac agaaaattga tatgtataaa cgcttcaggt ctgtggcgac aatcgaagag 63601 aagaatgagc ttcaagatga aatgatcgac cgctttggaa actatccaaa agaagtcgaa 63661 tacttgttta ctgttgcaga aatgaaagtc tatgcgagac aggaacgtgt cgagctgatt 63721 aagcaggata aagatgctgt cagattgacg atttctgaag aagcaagtgc tgaaattgac 63781 gggcagaagc tgtttgagct tggcaatcaa tatggcagac aaatcggact gggaatggaa 63841 gggaaaaaac tcaaaatctc catacagacg aaaggccgta gtgctgatga atggctcgac 63901 accgtgctgg gcatgctgaa gggcttaaaa gatgtgaaaa agcaaaccat ttcatcaacg 63961 taaattttgt tactctctgg tgtatattac atttgatgtg acggatacta atttcaagcg 64021 aggcggaagg tacataaagt aactgcttta ggtctttccc acatgtatat accatcaaat 64081 gaaagagagg caccagagat gaaagcaacc ggtatcgtac gtcgtattga tgacttaggt 64141 cgggtcgtga ttcctaaaga aattcgaaga actctgagaa tcagggaagg cgatccgctt 64201 gagatttttg tagatcgtga cggagaagtg attttgaaaa agtactctcc gatcagtgag 64261 cttggagact ttgcaaagga gtatgcagac gcgctttacg acagcctcgg ccattcagtg 64321 ctgatttgtg atcgtgatgt atatattgcc gtgtccggca gctccaaaaa agattactta 64381 aacaagtcaa tcagcgaaat gctggaaaga acaatggatc agcgcagctc cgtgcttgag 64441 agtgatgcga aatcagtaca gcttgtgaat ggaattgatg aggacatgaa ttcttatact 64501 gtaggcccaa ttgtggcgaa cggtgatccg ataggtgctg tggtgatctt ttcaaaagat 64561 cagacaatgg gcgaagtaga gcataaagcc gttgaaacag cagctggatt tttggctcgt 64621 caaatggaac agtaggtctt attcctttct tcgaaaatag gtatgtaaag aacagctctc 64681 cttgggacgc tgttcttttt catgcgtgcc gaaaaaggaa tccaagggtt gggatgtggt 64741 ataataacct cgtttttatt tgtgccgcgg taatacgtga accgtattgc ccctgacgtt 64801 gggaaggagc ttttggatgg acgattcaat aggcgttaaa cggcattgga tttggcaggg 64861 ggcttttgtt ttaattctgg caggcgtcat cacaaaaatt ttaagcgctg tttacagagt 64921 cccgtttcaa aacattgtcg gcgatgttgg attttatata tatcagcagg tatacccctt 64981 tcttggtatt gcggtcatgc tgtccacatc aggatttcca gtcattattt caaagctgat 65041 gaatgattat agtgaaaaaa atcatcacac catattaaaa atatcagcgt tgtttttgtc 65101 tttaatcggt attttattat ttctttgttt atatctgggt gctgttccta ttgcactctt 65161 tatgggagat tcgcatctag ccgtgttaat tcaagtggcc gcatacgcgt ttctgctttt 65221 cccatttgtc gcgttgctaa gaggcggttt tcaggggcgg cacgaaatgc tcccttcagc 65281 cttatcacag atgacagagc agtttctgcg tgttgcggtg ctcttgggtt tatcattttg 65341 gctcgtgaaa aagggagcct cgctttatac tgcgggagcg gcagccgctt caggctctct 65401 tgccggaagt ttggttgcat tgataatact ggggtttttt tggttcaaaa cgaaaagaga 65461 caaccaaacg gataggcaaa acgaaaatgt catcacaaca aaagaattga cgaaaaaact 65521 gcttttatat tcggtcacaa tttgtgtaag cagtttgctg cttttgttta tccagcttgt 65581 tgatgctttg aatttatatg cattgctttc gggtggtgag gcaagcgaag aagcaaaatg 65641 cctaaagggg atctatgatc ggggacaacc cttgttgcag ctcggttcag tttttgccgt 65701 aagcattgcg acgtcactcg ttccgtatat ttctatggct gtaaaaaaca aagagctgaa 65761 gatcatgaaa gaaaaaatca cgtcatcttt gaaactatgc cttgtgctcg gtacaggcgc 65821 atcggctggg ttgatttgca ttctaaagcc ggtaaatatc atgctgtttc aaaatggaga 65881 agggacaggt gcgttacaag tatttagctg ctccattttg tttgcatcct tggcggtaac 65941 ggcagcggca gtcttacagg gagcgggata cacagttttt cctgcgatag cggtgggcgc 66001 gggtgttgcg gtgaaatggg tgttaaacac acttttggtt ccgcgctatg ggattgaagg 66061 cgcatcgctt gcgacagcgg cttcctttgc ggctgtcgcc ggccttaact tgtatcagct 66121 tcggcaaaag gaatggctcg ataagcttag aggcgttttg attccgatta ttggatctgc 66181 tcttttgatg tcagctgttt tgcttgcgta tacgcgtctc tggactttct tgtttcctgc 66241 aacaggaaga ggagcggctg tgattgagag tctttctgct gttgccattg gtggcgcggt 66301 gtttatttat tgtatgatga gattgggaat atttacagat gaagagctga acagtgtgcc 66361 attcggcagc aagttaagca aattcatgag aaggagagaa caaaatggcg ggtaaaatta 66421 cagtcgtcgg acttggtgcc ggagacatgg accaattgac aattggtata cacaagctgc 66481 tgacgaaggc agatacgctg tatgtcagaa ccaaggatca tcctttaatt gaggagcttg 66541 aaaaagaaac gaagaacatc cgtttctttg atgatatata tgagaaacat gatcagttcg 66601 aggcggtata tgaagaaatt gcagatatcc tctttgaagc ggcgcggcgt gaggacgtgg 66661 tttacgctgt gccgggacac ccttttgtcg cagaaaaaac agttcagctg ctgacggagc 66721 ggcaggaaaa ggaaaacgtt caagtgaaag tcgcgggggg acaaagtttc cttgatgcca 66781 cattcaatgt cttgcaaatt gacccgattg aaggttttca atttgtggat gccggcacat 66841 tgtccgcgga tgagcttgag ctcagacatc atctgatcat atgtcaggtt tacgaccaaa 66901 tgacggcttc tgaagtcaag ctgacattga tggagaagct gcctgatgat tatgaggtcg 66961 tcattgtgac tgcagcaggc agccgtggcg aggagatcag gacagtgcca ttatttgagc 67021 tggaccgcaa tgtcgctttg aacaacttaa caagtgtgta tattccgccg attaaagaag 67081 agaagctgct ttatcacgaa ttctccacgt tccgaagcat catcagagag cttcgcggac 67141 ctaatggatg tccgtgggat aaaaagcaga cgcatcagtc attaaagcag tacatgattg 67201 aagaatgtta tgagcttctc gaagctattg acgaagaaga cacagaccat atgatcgaag 67261 agcttggcga cgttttgctt caggtcttgc ttcacgcgca aattggtgaa gatgaaggtt 67321 atttcacaat tgatgatgtc ataaaaggaa tcagtgaaaa aatggtccga agacatcccc 67381 atgtgtttaa agatgttaag gttcaggatg aaaacgatgt tttagccaat tgggaagata 67441 taaaaaaggc cgaaaaaaat acatctgaat catcattact agacagcgta ccgaaaaccc 67501 ttccagctct ttcgaaagca gctaaattgc agaaaaaagc agcgaaggtc ggttttgact 67561 gggaagacgt cagcgatatt tgggaaaagg taagtgagga aatgaaggaa ttttcttctg 67621 aggtttctga agctcctcac gaacacaatc ttaaagctga gtttggcgac attttgttcg 67681 cgctggtgaa tgtagcccgc ttctacaaaa tagagccaga ggaagcgctg accatgacta 67741 atgacaaatt ccggagacgg ttctcgtaca ttgaggaaac agcgaaggaa gagggagtcg 67801 agttggctga tatgtccctt gaggacatgg acaaactgtg gaatgaagca aaagaaactg 67861 agaggagatc atagatatga gattagataa atttttgaaa gtatcacggc tgatcaaacg 67921 gcgtacacta gcgaaggaag tagctgacca aggacgaatc tctattaacg gaaaccaagc 67981 taaagctagc tctgacgtaa aaccgggaga tgaactaacg gtccgcttcg gccaaaagct 68041 tgtaacggtt caagttaatg aattgaaaga cacgacgaaa aaagaagaag ctgcaaacat 68101 gtacacgatt ctaaaagaag aaaaactcgg cgaataggct tgttctaaaa aaacccccca 68161 cctcatacaa tgcagtaata atgctaaaag tatcgaggat atgggggctg aatagatgaa 68221 ttcatattat gatcaaaaag gttcttcgtc tgttccggaa cagcatgatg tgacaatgaa 68281 aggccggaag catttagata tttctggggt taagcatgtg gagagttttg ataacgaaga 68341 attcctgctg gaaacggtga tgggaatgct ctccgtcaga ggccaaaacc tgcagatgaa 68401 aaatcttgat gtggaaaaag ggattgtttc gattaaaggc agggtatttg atttagtgta 68461 cttagacgaa caacaagggg ataaagctaa agggtttttt agcaagttgt ttaaatgacg 68521 ctgacgacac aattctatac aatgctagcg atgtccggta tgggtctctg gcttggtgct 68581 tcgcttgata cataccggct ctttgtcatt cgtgccaaaa cagccagatg gctattattt 68641 attcatgata ttcttttctg gattatgcaa gggctgcttt tcttttatgt cttgcttcat 68701 gtaaatgagg gagaattcag gatttacatc tttttagcgg ttctgctggg cgttgcgacg 68761 tatcagagcc tttgcaaacg aatctatata aaaatactga aattcgtcat ttaccttgtt 68821 gtttctgttt atcaattctt caaaaaactc attcagcacg tgttatttcg tcctattgtg 68881 tggacatgcg gagcgatcat ctggctggcg gcatttttat tcaagaaaac atacagcctg 68941 ataggttttc tcctgctgtg tctatataaa atagtcatgg ttctgtgttt tccgatccgt 69001 tttatcgcga aacaatgttt gaaacttctt cctgtgaaaa tgcgtctaac ttttagacgt 69061 tattttgaaa aaggtgcagg atttctcaaa aagaagaaga aactattgat aaccataaga 69121 acgaccatca cacggttttt gaagagatga aaggaggacc gtctggtttg aatttttcca 69181 gggaacgaac gataactgaa atacaaaacg actataaaga acaagtagaa cggcaaaatc 69241 agctgaagaa acgaagacgc aaagggctgt acagacggtt aactgtattc ggcgccctag 69301 tattcctgac ggcaattgtg ctggcaagct ctgtatggtc ccaaacatct tcccttagtg 69361 caaaagaaga aaagaaagaa cagcttgaaa aagaactgaa aagtttaaag acaaaacaaa 69421 cggatttaaa agaagaaata tccaaattga aggatgagga ttacgtcaca gagcttgcca 69481 gaagggactt attcatgtct ggagacggag aaattatctt caatgtggag aagaagagca 69541 agtagccttg ttgacactta aatttttatt taggtataat taagcaaacg atctttttat 69601 aagcctaagg aggagcactt tttttatgtc gattgaagtt ggcagcaagt tgcaagggaa 69661 aattacaggt attacaaatt ttggagcatt tgttgaattg cctggaggct caaccggtct 69721 cgttcacatt agtgaggtag ctgataatta tgtcaaagac attaacgacc acttaaaagt 69781 cggcgaccaa gttgaagtga aagtcatcaa cgttgaaaaa gacgggaaaa ttggtttatc 69841 tattaaaaaa gctaaagacc gtccgcaagc cagacctaga aatgatttcc gtccgaaaga 69901 atcttttgaa cagaaaatga ataagttttt aaaagacagc gaagatcgct tgtcatcttt 69961 aaaacgcaat acggaatcaa aacgtggagg gcgcggagca agaagaggat aacttgctgc 70021 tttctataaa ataaatgaag catccgttca tcccgacgga tgctttttta ttatcctcat 70081 tctctttaag agtcagaaaa ttacaacatt aaagtttctg ttgacgaaag agacaaacct 70141 ttgtattata taacttgtgc ttagaagcac aaaacaatat ggcggtgtag ctcagctggc 70201 tagagcgtac ggttcatacc cgtgaggtcg ggggttcgat cccctccgcc gctaccatat 70261 ttgtttggcc cgttggtcaa gcggttaaga caccgccctt tcacggcggt aacacgggtt 70321 cgaatcccgt acgggtcatc ctaacaaatc ggtttctctt gcagaagccg atttttttca 70381 tttttagaca acattccgga aattcttttc ataaacgaat atcaaggcag aaaccgtcga 70441 agatttcttt ggtattgtta ccttcttttg acaaaatcct atctgtgctt tcgctataat 70501 gacaggcaac gaatataaca ggtgggagat gagaggaatg gaaaaagcag aaagaagagt 70561 gaacgggcca atggcgggac aagctttgga aaaactccaa tcgtttttta acaggggcac 70621 gaagctggtg actcatcatt tgcattcact gtttttctat aaaggattca tttatgttgt 70681 catcggattt ttgcttggac gggctttcat attatccgag gtgcttcctt tcgcacttcc 70741 tttctttgga gcgatgcttc ttatcagaag agacaaagcg ttttatgcgg ttttggctgt 70801 gcttgcaggt gcgctgacca tatctccaaa gcactcattg ctcatactgg cggcattgct 70861 ggcattcttc gtattttcta aagtggctgc cttcattacc gacgatcgtg ttaaagcgct 70921 cccgattgtc gtgttcttct ccatggctgc agcaagagcc gggtttgttt atgcccaaaa 70981 tggcgtattt acaacctatg attatgtaat ggctatcgtt gaggctggac tatcgtttat 71041 cttaacactg attttccttc agagccttcc gatttttact gtgaaaaaag tgaaacaatc 71101 attaaaaata gaggaaatca tttgctttat gattcttatt gcctctgttt taacggggct 71161 ggctggcttg tcctaccaag ggatgcaggc agaacatata ttggctcgtt atgttgtgtt 71221 gagtttttcc tttattggcg gagcaagcat cggctgtacg gttggggttg tgaccggcct 71281 gattcttggc ttggcgaata tcggaaacct atatcaaatg agtctgcttg ctttttccgg 71341 tttattgggc ggtttgctga aggaagggaa aaaagcgggt gcagcaattg gtttgatcgt 71401 tggatcactt cttatatctt tatatggtga aggctctgcc ggtctgatga caacgctcta 71461 tgagtcatta atcgcagtct gcctgttttt gctcacacct caatctatta cgaggaaagt 71521 ggcgagatat attccgggaa ctgtcgagca tcttcaagag caacagcaat acgctagaaa 71581 aatccgtgat gtcactgctc agaaggtaga ccaattctcc aatgtatttc acgcgctgtc 71641 tgaaagcttt gcaacctttt atcaagcatc agacgaacag acagatgaca gcgaagttga 71701 tctgttctta agcaaaatca cggagcattc ctgccagacg tgctacaaga aaaacaggtg 71761 ctgggtacag aactttgata aaacatatga cttaatgaaa caagttatgc ttgaaacaga 71821 ggaaaaagaa tatgcatcaa accgaaggct gaaaaaagag tttcaacagt attgttctaa 71881 atccaagcag gttgaagagc tgattgagga tgagctcgca catcatcatg cccatttgac 71941 actcaagaaa aaagtccaag acagcaggcg ccttgttgct gaacagcttt taggcgtttc 72001 tgaggttatg gccgactttt ctcgggaaat aaaaagagag cgagaacaac actttctgca 72061 ggaagagcaa atcatagaag cgcttcagca tttcggaatt gagattcagc atgtcgagat 72121 ctatagtctt gaacaaggaa atatcgatat tgaaatgacc attccgttca gcggacatgg 72181 agaaagtgaa aaaatcattg ctcctatgct ttctgacatt ctggaggaac aaattcttgt 72241 gaaagccgaa cagcactctc cgcatccgaa tggatacagc catgtcgcct ttggatcaac 72301 aaaatcatac agggtgtcca cgggagctgc tcacgctgcg aagggcggcg gccttgtctc 72361 cggtgacagc tacagcatga tggagcttgg agccagaaaa tatgctgcag caatcagtga 72421 cggaatgggc aatggcgcaa gagcgcactt tgaaagcaat gaaacgatca agcttcttga 72481 aaaaatcctt gaatcgggca ttgatgaaaa aatagcaatt aaaacgatca acagcatact 72541 gtctctaagg acaactgacg aaatatattc cacgcttgac ctatctatta tcgatcttca 72601 agatgccagc tgtaaatttt tgaaggttgg atcgacgccc agctttatca aacggggtga 72661 ccaggtcatg aaagttcaag cgagcaatct gccaatcggt attattaatg aattcgatgt 72721 ggaggttgtg agtgaacagc tgaaagcggg tgacctctta attatgatga gtgatggcat 72781 ttttgagggg cctaagcatg tggaaaatca cgacttatgg atgaagcgta aaatgaaagg 72841 gttgaaaaca aatgacccgc aggagattgc cgatttgctt atggaagaag tcatccgcac 72901 aagatccggc caaattgagg acgatatgac tgttgttgtc gtccggattg atcacaatac 72961 accgaagtgg gcatccattc ctgttccggc aatctttcaa aacaaacaag aaatttcata 73021 acgcttccgt ataaatcaaa tttcttctgg cgaagatggg aatatatgaa tctgagaatc 73081 ctcgtattct ccaggaggaa tgaatgtgaa caacggacat ttaaatcaaa ttttgctgat 73141 aacggatggc tgctcaaacc atggggaaga cccgcttgca atggctgctt ttgctaaaga 73201 gcaggggatt acggtaaatg tcattggtat aatggaagaa aatcaaattg accctgaggc 73261 aatgaaggaa gtcgaaggga ttgcacttgc cggaggaggc gtgcaccaag tcgtttatgc 73321 atctcagctt tcacaaactg ttcaaatggt aacaaagaaa gcgatgacgc aaaccttaca 73381 aggtgtagtc aatcaagaac tgaaacagat tctcggaaag aatgtggaaa tggaagagct 73441 ttctccggaa aaacgcggcg aagtcatgga agtggtagac gagcttggag aaacggtgca 73501 tcttcaggtt ttggttcttg ttgatacaag tgcaagtatg gcgccaaagc ttccaacagt 73561 aaaagaggcg ctgattgatt tgtctgtaag cctcaattcc cgaattggga ataacgaatt 73621 tgcgatgtgt atatttcccg ggaaaaaaca agaggtcgag cttgtgctga actggacacc 73681 gaagctgcaa tctctttcca cactctttgc aaagctttcg acaggcggca tcacgccgac 73741 aggtccggcg attcgtgaag cgacactgca gtttgaaaaa atacgctcaa gaaggggcat 73801 gctggcagat gatgaacgac gctttgacga gtttggcatg tagcctcaag ccgggtacga 73861 caatcaaagg caagtggaat ggaaacactt atacattgcg taaacagctt ggtaaagggg 73921 ccaatggaat tgtgtatttg gcagaaacat cagatggaca tgttgcctta aaggtgagtg 73981 atgacagcct gtctattact tctgaagtga atgtcttgaa atctttctca aaggcccagt 74041 ccgttacgat ggggccttct ttttttgata cggatgatgc ctatattccc agtgccaata 74101 cgaaagtttc attttatgca atggaataca taaaagggcc gctgcttttg aagtatgtca 74161 gtgataaagg agcagagtgg ataccggtat taatgattca gctgttatcc agcttatcgg 74221 tgcttcacca gcaaggatgg atattcggcg atcttaaacc tgataatctg atcgtaactg 74281 gtccgcccgc aaggatccgc tgcattgatg tgggcggcac gacaaaggaa ggccgggcga 74341 taaaagagta tacggagttt tatgacagag gctattgggg gtatggaaca agaaaggcag 74401 agccatccta tgatctgttc gcagttgcca tgattatgat caacagtgtg cataaaaaag 74461 aatttaagaa aacgaaccag cccaaagaac agcttaggtc tctcatcgaa ggaaacccgc 74521 tgcttcaaaa gtataaaaaa gcgctttttt cagccttgaa cggagattat caatccgcag 74581 atgaaatgaa aaaggatatg ctagacgcgg ggcaaaaagc agcacaaaga aaacagccta 74641 taaaagcatc accgcagcct gccacacgac aaagacagca aaaaccgcgc caaggaaaaa 74701 taacgaagac gcgatatacc ccaaaacaga aaccggctaa gtcggggggg ttatttgaaa 74761 caacgcttat cgtgatcagt gttttagcgc tttatttcgc ctatattatc tttttcttaa 74821 tctgaatggt gcaaactgca gagcctatgc ttcttctttg cttggagggg ttgaaagtgt 74881 taggatatga atatctttaa aatacctgct cattgtgagg aggacattgt gaaaagtgtc 74941 aaagattttt taaacaaaca caatcttacg ttaaaagggg cgacaatcat tgtaggcgtt 75001 tccggcggtc cggactcaat ggctcttctt cacgcgttgc atacgttatg cggccgttca 75061 gcgaatgtta ttgcagctca cgttgaccat cggttcagag gtgcggaatc cgaggaggac 75121 atgcgttttg tccaagctta ttgtaaagct gaacagctcg tgtgcgaaac ggctcaaatc 75181 aatgtaaccg catatgcaca ggaaaaagga ctcaataagc aggctgcagc acgcgattgc 75241 cgctaccagt tttttgagga aatcatgtcg aagcaccaag cggactatct ggctcttgcg 75301 catcatggtg atgaccaggt tgaaacaatg cttatgaaac tggctaaggg tacgcttgga 75361 acgggacttg cgggaatgca gccggttaga cgttttggga cagggcggat catcaggccg 75421 ttcttaacca ttacaaagga agagatcctt cactattgcc atgaaaacgg cttgagctac 75481 cggacggatg aaagcaacgc caaagatgac tacacaagaa acagattcag aaaaacagtg 75541 ctcccgtttt tgaagcagga atctccggat gtgcataaaa ggtttcagaa agtgagtgaa 75601 gcactgacgg aagatgagca attcttacag tcattaacga aagatgaaat gaataaagta 75661 atcacaagcc agtctaatac atcagttgaa atcaattcct ctcaattgct tgccctcccg 75721 atgcctttac aaagaagagg agttcaacta atattaaact atctttatga aaacgttcca 75781 tcatcctttt cagcccatca cattcagcag tttctcgatt gggcggaaaa tggcggtcct 75841 tcaggagtac tggactttcc gaaagggctg aaggtggtca aatcatatca gacatgtttg 75901 tttacatttg aacaatggca gtgcaaaaat gttccctttg aataccaaat tagcggagct 75961 gctgatgaaa cggcagtgct ccctaatgga tatctgatag aggcaaggca ttatgcggac 76021 tcgcctgaag aacatgggaa tgctgttttt atcacaagtg aaaaaaaggt gcgatttccc 76081 ttaacaatcc ggacgagaaa agctggagac cggatcaaac taaaagggat gaacggctca 76141 aaaaaggtaa aggatatatt tattgataag aaattgcctc tccaagaaag agacaactgg 76201 ccgattgtga cggacgcaag cggtgaaatt atctggatac ctggcttgaa aaaatcaatt 76261 tttgaagatc ttgtgattcc aaacagcgac cgcattgtat tacaatatag acagcatgaa 76321 aagtgtaggg ggcaagcaaa atcatgatga aacatgatat cgagaaagta ctgatctcag 76381 aggaagagat acaaaagaaa gtaaaagagt taggtgcaga attaacgagc gagtatcaag 76441 atacatttcc gttggcaatc ggtgtgttaa aaggagcact tccttttatg gcggatctta 76501 tcaagcatat tgatacatat ttggaaatgg atttcatgga tgtatcaagc tacggaaatt 76561 ctacggtttc ttctggagaa gtaaaaatca ttaaagattt ggatacatct gtagagggcc 76621 gggacatctt aattattgaa gatatcatcg acagtgggtt aaccttaagt tatctcgtag 76681 agctcttccg ataccgtaaa gcaaaatcaa ttaagattgt tacccttttg gataaaccga 76741 gcggaagaaa agcggacatc aaagcagact ttgtcggttt tgaagttcct gacgcgtttg 76801 tagtgggtta cggacttgat tatgctgagc gctatcgcaa tctgccttat atcggagtgt 76861 taaaaccggc agtttatgaa agctgatcgg cagcctgctt ccgagatggt tattgtttgt 76921 attggaatga ttttctatgg tactattgaa catagttgtg cttactgtgg gaggaggtaa 76981 ggaatgaatc gggtcttccg taataccatt ttttatttac ttattttatt agtagtaatc 77041 ggggttgtga gctacttcca gacctcaaat ccgaaaacag aaaatatgtc gtacagtacg 77101 ttcatcaaaa acctggatga cgggaaagtt gatagcgtat cggttcagcc tgtcagaggt 77161 gtttatgagg taaaagggca gctgaaaaac tacgacaaag atcaatactt tttgactcat 77221 gttcctgaag gaaagggagc agaccagata tttaacgctt tgaaaaagac agacgtaaag 77281 gttgagcccg cgcaagaaac aagcggatgg gtgacgttcc tgacgaccat catcccattt 77341 gtcattatct ttattctgtt tttcttcctg ctcaatcagg ctcaaggcgg cggcagccgt 77401 gtcatgaact ttggcaagag taaagcgaag ctgtatacag aggaaaagaa acgcgtcaaa 77461 tttaaagacg ttgcaggggc tgacgaagaa aagcaagaac ttgttgaagt tgttgagttt 77521 ctgaaagatc cccgcaagtt tgccgagctc ggcgccagaa taccgaaagg cgtgctttta 77581 gtcggacctc cgggtaccgg taaaacattg cttgccaagg cttgtgcagg agaagccggc 77641 gtacctttct tcagcatcag cggatctgat ttcgttgaaa tgtttgtagg ggtcggtgct 77701 tcccgtgtgc gtgacttgtt tgaaaatgcg aaaaagaatg cgccttgttt gatcttcatt 77761 gatgaaattg acgcagtcgg acgccagcgt ggcgctggtc tcggcggtgg acacgatgaa 77821 cgtgaacaga cgctaaacca attgcttgtt gaaatggacg gattcagcgc taatgaagga 77881 attatcatca ttgctgcgac gaaccgtgcg gacatcttgg acccagcctt acttcgtccg 77941 ggacgttttg accgtcaaat cacagtggac cgcccagatg tcattggccg tgaagctgta 78001 ttgaaagtcc atgcgagaaa caaaccgctg gatgaaacgg ttaacctaaa atcaattgcc 78061 atgagaacac caggcttctc aggcgctgac ttagaaaacc tcttgaatga agctgcgctt 78121 gtagcggctc gtcaaaacaa gaaaaaaatc gatgcgcgtg atattgacga agcgacggac 78181 cgtgtaattg ccggacccgc taagaagagc cgcgttatct ccaagaaaga acgcaatatc 78241 gtggcttatc acgaaggcgg acacaccgtt atcggtctcg ttttagatga ggcagatatg 78301 gttcataaag taacgattgt tcctcggggc caggctggcg gttatgctgt tatgctgcca 78361 agagaagacc gttatttcca aacaaagccg gagctgcttg ataaaattgt cggcctcttg 78421 ggcggacgtg ttgctgaaga gattatcttc ggtgaagtca gcacaggggc gcacaatgac 78481 ttccagcgtg cgacgaatat tgcaagacga atggttacag aattcggtat gtcagaaaaa 78541 ctgggaccgt tgcaatttgg acagtctcag ggcggtcagg tattcttagg ccgtgatttc 78601 aacaacgaac agaactacag tgatcaaatc gcttacgaaa ttgatcagga aattcagcgc 78661 atcatcaaag aatgttatga gcgtgcgaaa caaatcctga ctgaaaatcg tgacaagctt 78721 gaattgattg cccaaacgct tctgaaagtt gaaacgcttg acgctgaaca aatcaaacac 78781 cttatcgatc atggaacatt acctgagcgt aatttctcag atgatgaaaa gaacgatgat 78841 gtgaaagtaa acattctgac aaaaacagaa gaaaagaaag acgatacgaa agagtaattc 78901 gctttctttc taaaaaaact gccggctgac gctggcagtt tttttatgta aatgattggc 78961 tcagctgcgg cttttacaat catccaattc tggtatcgat ttgtttacaa atgagccgct 79021 gatcgtgtat ggtattgtag aatgtttgta aaaagtaaag tagagaaact attcaaaagt 79081 ggtgatagag gttgttactg gttatcgatg tggggaacac caatactgta cttggtgtat 79141 atcatgatgg aaaattagaa tatcactggc gtatagaaac aagcaggcat aaaacagaag 79201 atgagtttgg gatgattttg cgctccttat ttgatcactc cgggcttatg tttgaacaga 79261 tagatggcat tattatttcg tcagtagtgc cgccaatcat gtttgcgtta gaaagaatgt 79321 gcacaaaata ctttcatatc gagcctcaaa ttgttggtcc aggtatgaaa accggtttaa 79381 atataaaata tgacaatccg aaagaagtag gggcagacag aatcgtaaat gctgtcgctg 79441 cgatacactt gtacggcaat ccattaattg ttgtcgattt cggaaccgcc acaacgtact 79501 gctatattga tgaaaacaaa caatacatgg gcggggcgat tgcccctggg attacaattt 79561 cgacagaggc gctttactcg cgtgcagcaa agcttcctcg tatcgaaatc acccggcccg 79621 acaatattat cggaaaaaac actgttagcg cgatgcaatc tggaatttta tttggctatg 79681 tcggccaagt ggaaggaatc gttaagcgaa tgaaatggca ggcaaaacag gaaccaaagg 79741 tcattgcgac aggaggcctg gcgccgctca ttgcgaacga atcagattgt atagacatcg 79801 ttgatccatt cttaacccta aaagggctgg aattgattta tgaaagaaac cgcgtaggaa 79861 gtgtatagga ggtttagtaa tggattattt agtaaaagca cttgcgtatg acggaaaagt 79921 tcgggcttat gcagcgagaa cgactgatat ggtaaatgag gggcagagac gccatggtac 79981 gtggccgaca gcatccgctg cactaggccg tacaatgaca gcttcactta tgctcggcgc 80041 tatgctgaag ggcgatgata agctgaccgt gaaaatcgag ggcggaggtc cgatcggagc 80101 tattgtagct gatgccaatg ccaaaggaga agtcagagcc tatgtctcta acccgcaagt 80161 tcattttgat ttaaatgaac aaggtaagct tgatgtcaga cgtgcggttg gaacaaacgg 80221 aacgttaagt gtcgtaaaag atttaggttt gcgcgagttc ttcacaggac aagtagaaat 80281 cgtttcagga gaattaggag atgattttac ttactatctt gtgtcatctg agcaggttcc 80341 ttcatcagtg ggcgtaggtg tgctcgtaaa tcctgacaat accattcttg cggcaggggg 80401 ctttattatt cagctgatgc cgggaacaga tgatgaaaca atcacaaaaa ttgaacagcg 80461 tctatctcaa gtagagccga tttctaagct catccaaaaa gggctgacac cagaagaaat 80521 tttagaagaa gtcctaggcg agaaacctga gattttggaa acgatgcctg tcagattcca 80581 ttgcccttgt tcaaaagaac ggttcgaaac agccatttta ggactaggca aaaaagaaat 80641 tcaagatatg atagaagaag atggacaagc cgaagcagta tgccattttt gtaatgaaaa 80701 gtacttattt acaaaagaag agctggaagg gcttcgtgac caaactaccc gctaagctct 80761 ttagcgggtt tttaatttga gaaaaggggc tgaaagcagg tttgaaatca agaacaatct 80821 ggaccattat tttaggggcg ctgttggttt gctgtattgc tgttgcatat acgctgacga 80881 aatcccaagc cggcgcatcg tcatccggtg agtctattgc gactatcgga ggcaagagtg 80941 tgacaagaga agaatggctg aaagaaatgg aagatcagta tggtaagtca acgcttgaag 81001 atatgatcaa tgtccgagtt gttgagcagc tggctaaaaa gaacaaactt aaaatatcca 81061 aaagcgaagt tgatcgtgag tttttgctga ttaaagcggt caataattcc ttttacgaag 81121 atgaacatac gacggagaaa gagtggaaag accaaattcg ttataatatc ctccttgagg 81181 atttgttaac aagggatatc gatatctcaa acaaagaatt ggaatcattc tataataaaa 81241 ataaggaact atatcagttt gatgattcgt atcgaattcg gcacattgtt gtaaaagatg 81301 aagaagaagc aagagaagtc ctgaaagaac tgaaaggcgg atcaagcttt gaagctgtcg 81361 ctgccgaaag atctacagac agatatacat caccatacgg cggagattta ggttttgtca 81421 cagaggcatc agacaacatt ccatcagcat acattgaaga ggcgaaaaca ctcaaagagg 81481 atgaatggtc tcaggaacca ataaaggtca gcaacggata tgccattatc cagctgaaag 81541 aaaaactaaa ggcaagaacg ttctcatttg atgaagtaaa ggaccagatc agacggcaaa 81601 tcgcaatgga tcagctaggc gataaagcga cagttaagac actttggaaa gaagccgatg 81661 tatcttggtt ttatggggaa aaaagtacta agtgattgac aaaaaatttt gaaattgata 81721 gattatatac ataataccaa tacaaatagt cggaaattga ggtgtcgaga atggtacgtg 81781 tagcaaactc cattactgaa ttaattggga atacgccaat cgttaaatta aatcgccttg 81841 cagatgaaaa cagtgcggat gtatatctaa aacttgaata catgaaccct ggaagcagtg 81901 taaaagaccg tatcggttta gctatgattg aagcggctga aaaagaagga aaattaaaag 81961 ccggtaatac aatcattgaa ccgacaagcg gaaatactgg aatcgggctt gcaatggttg 82021 ctgctgctaa aggattaaaa gccattttgg ttatgcctga tacaatgagc atggagcgcc 82081 gcaaccttct tcgcgcatat ggtgctgagc ttgtgctgac tcctggtgcg gaaggcatga 82141 aaggtgctat taagaaagct gaagagcttg ctgaaaagca cggatacttt gtgccgcagc 82201 agtttaacaa cccttctaac cccgaaattc accgccaaac aacgggtaaa gaaatcgttg 82261 agcaattcgg tgatgatcag cttgacgcat ttgtagccgg aatcggaacg ggcggaacga 82321 ttacgggagc gggcgaagtg ctgaaggaag catacccttc catcaagatt tatgctgttg 82381 aaccgtcaga ttccccagtg ctttcaggag gaaaaccagg cccccacaaa attcagggaa 82441 tcggagcagg attcgtgccg gacatcttaa acactgaagt atatgatgaa atcttccctg 82501 tgaagaatga agaagcattc gaatatgccc gcagagctgc acgtgaagaa ggaattctcg 82561 gaggcatctc atcaggtgcg gcaatttatg ctgctcttca agtagcaaaa aaactcggaa 82621 aaggcaaaaa agtattggcc atcattccaa gtaacggcga acgttatcta agcacgccgc 82681 tgtaccaatt cgattaaaaa aagccaaaac tcccggttcg ccgggagttt ttttatattt 82741 cgtgcatcaa atatgccatg tctgcgacga atgttattct tggaagagaa attcactttt 82801 ttcactaaca acattgcttt acaattaaaa acaagtaaaa aagaaaatag aggaatgata 82861 caaatggcac aacgcagacc ggcaggcaaa aaaatacctt ttcaaaaaga ctcattctta 82921 caacaatttg agaaacttgc gcaatcccgg aaacatcatg tacttctcga aagtgcaaga 82981 ggcggcagat atagtatagc cggtcttgat ccaattgcga ctgtgaaagg aaaagacgga 83041 ataactacaa ttaagcatgg tgatgagatg ctgtttaaag aaggtgatcc attacgggcc 83101 ttccacagct ggtttaaaac actggaaaca gaaacgaatc atgagttccc tgactttcaa 83161 ggcggggcaa tcgggtttct cagctatgat tacgcacggt acattgaaaa ttttaaaatg 83221 ctctcattag atgatttaga aacaccagat atttattttc ttgtttttga tgatatagca 83281 gtttatgacc atcaagaaga gtctctatgg ctgattactc atgttaatgg ttctgatcag 83341 gaaacagcgg atgtgaagct atctgagtta gagcagatgt ggttgactga gcttcccgct 83401 gtcacttcgc gagagatgaa gcctgaaaca gctggttctt tcgcggcgcc atttaccgag 83461 gatgggttct cacaagctgt agagaaaatc aaacaataca ttgccagcgg agatgtgttt 83521 caagtcaatc tatcaataag gcagtcacag tcactgtctg tccacccata tcaaatttac 83581 aaaaccttga gagaagtaaa tccttctcct tatatggcgt atttagaaac acctgatttc 83641 caaatcattt gcggatcgcc tgaactgctt gtcagcaaaa agggcaagct attagagacg 83701 agaccgattg cgggcacccg ttccagaggg aaaacaaatg aagaagacga ggcgcttgca 83761 aacgaattga tacacaatga aaaagaacgc gcggaacatg tcatgctggt tgatcttgag 83821 cgaaatgatc tgggaagagt atcacgttac gggtctgtgc gcgtaaatga attcatggca 83881 attgaaaaat actcgcatgt gatgcacatt gtgtctaatg tccaaggtga actgcaggat 83941 gggtatgatg ctgtagatat tattcatgct gtgtttcccg gaggaaccat tactggtgca 84001 ccgaaagtaa gaacgatgga aattatagaa gaacttgagc cgacacgccg agggctttat 84061 actggatcta taggatggtt tggatataat cacgatctgc agtttaatat cgtcattcga 84121 accatttatg caaccggagg gcaggcattt atgcagtccg gtgcaggagt tgtgattgat 84181 tctgttccga agcacgaata caaggaatca ttcaaaaaag cttttgcgat gcaaagagca 84241 ttagagctga gcgaagaaga gacaaaaatt agatgaggtg agcggagaaa tgattttaat 84301 gattgataac tacgattcat tcacgtacaa cttggtacag tatttgggcg agcttgggga 84361 agagctggtt gtgaaacgca atgacagcat cacaatcgat gaaattgaag aactgtctcc 84421 ggactttctg atgatatctc ccggaccgtg cagccctgat gaggcgggaa tcagcctcga 84481 agcaattaaa catttcgcag ggaaaattcc tattttcggt gtatgtctcg gacatcagtc 84541 catcgcacaa gtgttcggtg gtgatgttgt tagggcagaa cggcttatgc acgggaaaac 84601 ctcggatatc gagcatgacg gcaaaaccat ttttgaaggg ttgaaaaatc cccttgttgc 84661 gacgcgatac cactcgctga tcgtaaaacc tgagacgctg ccaagctgtt ttacagtaac 84721 agcacaaacg aaagaaggag aaatcatggc tattcgccac aatgacctcc cgatagaggg 84781 tgtgcaattt cacccagagt ctattatgac ctcctttggg aaagaaatgc tcagaaattt 84841 tattgagaca tatcgcaagg aagttattgc gtgatgatat atgtgaacgg ccggtatatg 84901 gaggagaaag atgcagttct ttctcctttt gaccatgggt ttttatatgg gatcggtgtt 84961 ttcgaaacct tcaggctcta cgaaggctgc ccgtttttgc ttgattggca tatagagagg 85021 cttgaacgcg cgcttaagga tctgcaaatc gaatatactg tttcaaagca tgagatcctt 85081 gagatgctgg acaagctgct taagctaaat gatatcaagg atggcaatgc ccgcgtcaga 85141 ctgaacatat cagcgggaat cagcgataaa ggctttgtcg cccagacgta cgataagccc 85201 accgttttat gctttgtgaa tcagctgaaa ccagaaagtc ttcctttgca aaaagaagga 85261 aaggttttat cgatacggag aaacactcca gagggatcgt tccggttaaa atctcatcat 85321 tatctaaata atatgtatgc gaaacgggaa attggaaatg atccgcgtgt cgagggaatt 85381 ttcttaacgg aggatggagc tgttgcagag ggtatcatat ctaatgtctt ctggagaaaa 85441 ggtcgctgta tctatacgcc atcgcttgat accggtattc tggacggcgt cacgagacgt 85501 tttatcatag aaaatgcaaa ggatatcggc ctggagctca aaacgggccg atatgagcta 85561 gaagctctct tgacagctga cgaagcgtgg atgacgaact cggttcttga aatcatcccg 85621 tttactaaaa tagaagaagt aaactatgga agccaaagcg gagaagcaac ctccgctctt 85681 caattgttat acaaaaaaga aataaagaac atgattcatg aaaagggagg aagagcatgg 85741 cgcagcacac aatagatcaa acacaagtaa tccacactaa gcccagcgct ttatcatata 85801 aagagaagac gctggtgatg ggaattttaa acgtaacgcc tgactctttc tcggacggcg 85861 gaaaatatga cagcttggac aaggcgctgc tgcacgcgaa agagatgatc gatgatggtg 85921 cccatatcat tgatattgga ggggaatcga caaggcctgg cgctgagtgc gtatctgagg 85981 atgaggagat gtccagagtc attccggtga ttgagcggat tacgaaagag cttggtgttc 86041 ctatttctgt agacacgtac aaggcttctg tcgcagatga agcagtgaaa gccggtgcat 86101 ccattatcaa tgatatttgg ggagccaaac atgatccgaa gatggcttcc gttgcagctg 86161 aacataatgt tccaattgta ctcatgcata accgccctga aagaaactac aatgacttat 86221 tgccggatat gctgtcggac ttaatggaga gtgtaaaaat tgctgttgag gccggagtag 86281 acgagaagaa cattattctt gatcctggta tcggtttcgc gaaaacctat cacgataact 86341 tggcagtgat gaacaaacta gagattttca gcggattggg atatccggtt cttctggcaa 86401 cctcccgaaa aagattcatc ggacgtgttc tggatcttcc gcctgaggag cgggctgagg 86461 gcacaggcgc gactgtgtgt ctcggcattc aaaaaggctg tgacattgtc agggtccatg 86521 atgtaaagca aattgccaga atggcgaaaa tgatggacgc gatgctgaat aagggagggg 86581 tgcaccatgg ataaagttta tgtagaaggt atggagtttt acggatatca cggtgtgttc 86641 acagaagaaa acaaacttgg ccagcggttt aaagtcgatt taaccgctga gctggattta 86701 agcaaagctg gacagacaga cgaccttgag caaacgatca actatgctga gctctatcac 86761 gtatgtaaag atatcgtgga aggggagcct gtgaaattgg tggaaacgct ggcggaacgt 86821 attgctggca ctgttctcgg aaaatttcag cctgttcagc aatgtacggt gaaagtgatt 86881 aagccagacc cgccaattcc cggacactat aaatcagtag caattgaaat tacgagaaaa 86941 aagtcatgaa caacatagct tatattgcac ttggatctaa tattggagat agagaaacgt 87001 atttaaggca agcagtggct ttactgcatc agcatgctgc ggtgacagtc actaaagtgt 87061 cgtctattta cgaaactgac ccggtcggat acgaagatca agctcaattt ttgaatatgg 87121 ctgttgaaat caagacatca ttgaaccctt ttgaactcct tgaactgacg cagcagatag 87181 aaaatgaatt aggcagaaca agggaagtaa gatgggggcc gcggacggca gaccttgaca 87241 ttttgttatt taatcgtgaa aatattgaaa cagagcaact aattgttccg catccgagaa 87301 tgtatgagcg tttgtttgtc cttgcgccgc ttgcggaaat ttgccagcag gttgaaaaag 87361 aggctacaag cgccgaaaca gaccaagaag gtgtaagagt atggaagcag aaatctgggg 87421 tagacgaatt cgtgcattca gaaagctgaa aggttatact caagaaggat ttgcaaaagc 87481 attaggtata tcagtttcta ttctcggcga aattgaacgc ggaaaccgat tgccgtctgc 87541 tgccatcatt caagatgcag cagatgtttt aaatataagt gcggacgaat tggcgccgcc 87601 agaaaaatag aacaaatgaa aggaggagaa aaattgttca aaatcggaga tattcaattg 87661 aaaaaccggg ttgtgctcgc acctatggct ggtgtctgca actctgcgtt cagattgact 87721 gtaaaggaat tcggagccgg attggtatgc gctgaaatgg tcagtgacaa agcgatcctt 87781 tacaacaatg caagaacaat gggtatgctt tatattgatg aacgtgagaa accactgagc 87841 cttcaaattt tcggaggaaa aaaggaaacc cttgtggaag cggcgaagtt tgtagaccaa 87901 aacacaactg ctgatatcat tgatattaac atgggatgtc ccgtgccgaa gattacaaaa 87961 tgcgatgcgg gagccaaatg gcttctcgat cctgataaga tttacgaaat ggtttctgca 88021 gtagtggatg ctgttaataa gccagttaca gtgaaaatga gaatgggctg ggatgaagac 88081 cacattttcg cagtgaaaaa tgcacaggct gtagaacgtg cgggcggtaa agcagtggcg 88141 cttcacggcc gtacgagagt gcagatgtac gaaggaacgg caaactggga tatcatcaaa 88201 gaagtaaaac aatcagtatc gattccggtt atcggaaacg gcgatgttaa gacaccgcag 88261 gatgctaagc gtatgctcga tgagacagga gtagacgggg tcatgatcgg acgcgctgca 88321 ttgggtaacc cgtggatgat ttaccgtacg gttcagtatc ttgaaacagg taaattaaaa 88381 gaagagccgc aagtacgcga aaaaatggcc gtatgcaaac tgcatcttga ccgcctgatt 88441 gacttaaaag gtgaaaacgt agcggtaaga gaaatgagaa agcacgctgc atggtatctg 88501 aaaggcgtga aaggcaatgc gaacgttcgt aatgaaatca atcattgcga gacgagagaa 88561 gagtttgtac agcttttaga tgcatttacg gttgaagttg aggcaaaaga gcttcaaaat 88621 gcaaaagtag gataatactc acctctattt gctgctcact gctagtttta cgctggcagt 88681 ttttctgctt ttttcatgaa acaatatctg taatggagtg ataacaatga gtcaagaaga 88741 gcataaccat gaagaattga atgatcagct gcaagtcaga cgcgataaaa tgaatcagct 88801 gagagataac ggcatcgatc cattcggcgc acgttttgaa agaactcatc agtctcaaga 88861 agttatttcg gcatatcaag atctaaccaa agaagagtta gaagaaaaag cgattgaagt 88921 tacaatcgca ggccgcatga tgacaaaacg cggcaaagga aaagccggct ttgcccatct 88981 tcaggattta gaaggccaaa tccaaatcta cgtaagaaaa gacagtgtcg gtgacgacca 89041 atatgaaatc ttcaagtctt ctgacctcgg tgatcttatc ggcgtaaccg gaaaagtctt 89101 caaaacaaat gtaggcgaat tgtctgttaa agcaacttcc tttgaattgc tgacaaaagc 89161 gcttcgtccg cttcctgaca aataccatgg tttaaaagac gttgagcagc gctaccgtca 89221 gcgctatctg gatcttatcg taaacccaga cagcaaacat acgttcatta cacgaagcaa 89281 gatcattcaa gctatgagaa ggtaccttga tgatcatgga tacttagaag tagaaacacc 89341 tacaatgcac agcattcctg ggggagcttc tgcacgtccg tttatcactc accacaacgc 89401 gttagacatt ccactctata tgcgtattgc tatcgaactg cacctaaaac gtctaattgt 89461 cggcggttta gaaaaagtat atgaaatcgg ccgtgttttc cgtaacgaag gtgtctctac 89521 acgccataac cctgaattta caatgattga gttatatgaa gcatatgcgg actataaaga 89581 tatcatgagc ttaactgaaa accttgtcgc tcatatcgcc caagaagtgc ttggcacaac 89641 tacgattcaa tacggggaag agcaaatcga ccttaaaccg gagtggaaaa gaatccatat 89701 ggttgacgca gtcaaagaag cgaccggcgt tgatttctgg gaagaggtta ctgttgagca 89761 ggcgcgtgaa tatgcaaaag aacatgaagt agaaattaaa gactctatga cagtaggcca 89821 tatcatcaac gaattcttcg aacaaaaaat tgaagaaacg cttattcagc caacgtttat 89881 ttacgggcat cctgtagaaa tttctcctct tgctaagaaa aaccctgagg acccgcgttt 89941 tacagaccgt tttgagctgt ttatcgttgg ccgtgaacat gccaacgcgt ttacagagct 90001 gaatgatcct attgatcaaa gagaacgctt tgaagcgcaa ttaaaagagc gtgaagccgg 90061 taatgatgaa gctcatttaa tggatgaaga ctttgttgaa gctctggaat acggtatgcc 90121 gccaacagga ggtttaggca tcggtatcga ccgtctggtt atgctgctga cgaatgcccc 90181 ttctattcgc gatgtgctgt tattcccgca aatgagacaa cgctaataaa aaagagcggt 90241 atcctccata gggaaaggat gccgctcttt ttaaatccct tagtatttct tcaaaaaaac 90301 tattgcacta ttatttacta ggtggtatat tattattcgt tgccgctaaa caaggcgata 90361 acgaaaaaaa gaacttcaaa aaaagttatt gacttcactg agtcaacgag ttataataat 90421 aaagtcgctt gaacgaagtg aacaaaatga tctttgaaaa ctaaacaaga caaaacgtac 90481 ctgttaattc agtttttaaa aatcgcacag cgatgtgcgt agtcagtcaa actactttat 90541 cggagagttt gatcctggct caggacgaac gctggcggcg tgcctaatac atgcaagtcg 90601 agcggacaga tgggagcttg ctccctgatg ttagcggcgg acgggtgagt aacacgtggg 90661 taacctgcct gtaagactgg gataactccg ggaaaccggg gctaataccg gatggttgtt 90721 tgaaccgcat ggttcaaaca taaaaggtgg cttcggctac cacttgcaga tggacccgcg 90781 gcgcattagc tagttggtga ggtaatggct caccaaggca acgatgcgta gccgacctga 90841 gagggtgatc ggccacactg ggactgagac acggcccaga ctcctacggg aggcagcagt 90901 agggaatctt ccgcaatgga cgaaagtctg acggagcaac gccgcgtgag tgatgaaggt 90961 tttcggatcg taaagctctg ttgttaggga agaacaagtg ccgttcgaat agggcggtac 91021 cttgacggta cctaaccaga aagccacggc taactacgtg ccagcagccg cggtaatacg 91081 taggtggcaa gcgttgtccg gaattattgg gcgtaaaggg ctcgcaggcg gtttcttaag 91141 tctgatgtga aagcccccgg ctcaaccggg gagggtcatt ggaaactggg gaacttgagt 91201 gcagaagagg agagtggaat tccacgtgta gcggtgaaat gcgtagagat gtggaggaac 91261 accagtggcg aaggcgactc tctggtctgt aactgacgct gaggagcgaa agcgtgggga 91321 gcgaacagga ttagataccc tggtagtcca cgccgtaaac gatgagtgct aagtgttagg 91381 gggtttccgc cccttagtgc tgcagctaac gcattaagca ctccgcctgg ggagtacggt 91441 cgcaagactg aaactcaaag gaattgacgg gggcccgcac aagcggtgga gcatgtggtt 91501 taattcgaag caacgcgaag aaccttacca ggtcttgaca tcctctgaca atcctagaga 91561 taggacgtcc ccttcggggg cagagtgaca ggtggtgcat ggttgtcgtc agctcgtgtc 91621 gtgagatgtt gggttaagtc ccgcaacgag cgcaaccctt gatcttagtt gccagcattc 91681 agttgggcac tctaaggtga ctgccggtga caaaccggag gaaggtgggg atgacgtcaa 91741 atcatcatgc cccttatgac ctgggctaca cacgtgctac aatggacaga acaaagggca 91801 gcgaaaccgc gaggttaagc caatcccaca aatctgttct cagttcggat cgcagtctgc 91861 aactcgactg cgtgaagctg gaatcgctag taatcgcgga tcagcatgcc gcggtgaata 91921 cgttcccggg ccttgtacac accgcccgtc acaccacgag agtttgtaac acccgaagtc 91981 ggtgaggtaa ccttttagga gccagccgcc gaaggtggga cagatgattg gggtgaagtc 92041 gtaacaaggt agccgtatcg gaaggtgcgg ctggatcacc tcctttctaa ggatatttta 92101 cggaatataa gaccttgggt cttataaaca gaacgttccc tgtcttgttt agttttgaag 92161 gatcattcct tcgaaacgtg ttctttgaaa actagataac agtagacatc acattcaagt 92221 aatacaagat atcacatagt gattcttttt aacggttaag ttagaaaggg cgcacggtgg 92281 atgccttggc actaggagcc gatgaaggac gggacgaaca ccgatatgct tcggggagct 92341 gtaagcaagc tttgatccgg agatttccga atggggaaac ccaccactcg taatggagtg 92401 gtatccatat ctgaattcat aggatatgag aaggcagacc cggggaactg aaacatctaa 92461 gtacccggag gaagagaaag caaatgcgat tccctgagta gcggcgagcg aaacgggatt 92521 agcccaaacc aagaggcttg cctcttgggg ttgtaggaca ctctgtacgg agttacaaag 92581 gaacgaggta gatgaagagg tctggaaagg cccgccatag gaggtaacag ccctgtagtc 92641 aaaacttcgt tctctcctga gtggatcctg agtacggcgg aacacgtgaa attccgtcgg 92701 aatccgggag gaccatctcc caaggctaaa tactccctag tgaccgatag tgaaccagta 92761 ccgtgaggga aaggtgaaaa gcaccccgga aggggagtga aagagatcct gaaaccgtgt 92821 gcctacaagt agtcagagcc cgttaacggg tgatggcgtg ccttttgtag aatgaaccgg 92881 cgagttacga tcccgtgcaa ggttaagcag aagatgcgga gccgcagcga aagcgagtct 92941 gaatagggcg catgagtacg tggtcgtaga cccgaaacca ggtgatctac ccatgtccag 93001 ggtgaagttc aggtaacact gaatggaggc ccgaacccac gcacgttgaa aagtgcgggg 93061 atgaggtgtg ggtaggggtg aaatgccaat cgaacctgga gatagctggt tctctccgaa 93121 atagctttag ggctagcctc aaggtaagag tcttggaggt agagcactga ttggactagg 93181 ggcccctacc gggttaccga attcagtcaa actccgaatg ccaatgactt atccttggga 93241 gtcagactgc gagtgataag atccgtagtc gaaagggaaa cagcccagac cgccagctaa 93301 ggtcccaaag tatacgttaa gtggaaaagg atgtggagtt gcttagacaa ccaggatgtt 93361 ggcttagaag cagccaccat ttaaagagtg cgtaatagct cactggtcga gtgactctgc 93421 gccgaaaatg taccggggct aaacgtatca ccgaagctgc ggactgttct tcgaacagtg 93481 gtaggagagc gttctaaggg ctgtgaagcc agaccggaag gactggtgga gcgcttagaa 93541 gtgagaatgc cggtatgagt agcgaaagag gggtgagaat cccctccacc gaatgcctaa 93601 ggtttcctga ggaaggctcg tccgctcagg gttagtcggg acctaagccg aggccgaaag 93661 gcgtaggcga tggacaacag gttgatattc ctgtaccacc tcctcaccat ttgagcaatg 93721 gggggacgca ggaggatagg gtaagcgcgg tattggatat ccgcgtccaa gcagttaggc 93781 tgggaaatag gcaaatccgt ttcccataag gctgagctgt gatggcgagc gaaatatagt 93841 agcgaagttc ctgattccac actgccaaga aaagcctcta gcgaggtgag aggtgcccgt 93901 accgcaaacc gacacaggta ggcgaggaga gaatcctaag gtgatcgaga gaactctcgt 93961 taaggaactc ggcaaaatga ccccgtaact tcgggagaag gggtgctctg ttagggtgca 94021 agcccgagag agccgcagtg aataggccca ggcgactgtt tagcaaaaac acaggtctct 94081 gcgaagccgt aaggcgaagt ataggggctg acgcctgccc ggtgctggaa ggttaagagg 94141 agcgcttagc gtaagcgaag gtgcgaattg aagccccagt aaacggcggc cgtaactata 94201 acggtcctaa ggtagcgaaa ttccttgtcg ggtaagttcc gacccgcacg aaaggcgcaa 94261 cgatctgggc actgtctcaa cgagagactc ggtgaaatta tagtacctgt gaagatgcag 94321 gttacccgcg acaggacgga aagaccccgt ggagctttac tgcagcctga tattgaatgt 94381 tggtacagct tgtacaggat aggtaggagc cttggaaacc ggagcgccag cttcggtgga 94441 ggcatcggtg ggatactacc ctggctgtat tgaccttcta acccgccgcc cttatcgggc 94501 ggggagacag tgtcaggtgg gcagtttgac tggggcggtc gcctcctaaa aggtaacgga 94561 ggcgcccaaa ggttccctca gaatggttgg aaatcattcg cagagtgtaa aggcacaagg 94621 gagcttgact gcgagaccta caagtcgagc agggacgaaa gtcgggctta gtgatccggt 94681 ggttccgcat ggaagggcca tcgctcaacg gataaaagct accccgggga taacaggctt 94741 atctccccca agagtccaca tcgacgggga ggtttggcac ctcgatgtcg gctcatcgca 94801 tcctggggct gtagtcggtc ccaagggttg ggctgttcgc ccattaaagc ggtacgcgag 94861 ctgggttcag aacgtcgtga gacagttcgg tccctatccg tcgcgggcgc aggaaatttg 94921 agaggagctg tccttagtac gagaggaccg ggatggacgc accgctggtg taccagttgt 94981 tctgccaagg gcatcgctgg gtagctatgt gcggacggga taagtgctga aagcatctaa 95041 gcatgaagcc cccctcaaga tgagatttcc cattccgcaa ggaagtaaga tccctgaaag 95101 atgatcaggt tgataggtct gaggtggaag tgtggcgaca catggagctg acagatacta 95161 atcgatcgag gacttaacca tatttttgaa tgatgtcaca tctgttatct agttttgaga 95221 gaacactctc aatttgtttg gtggcgatag cgaagaggtc acacccgttc ccataccgaa 95281 cacggaagtt aagctcttca gcgccgatgg tagtcggggg tttccccctg tgagagtagg 95341 acgccgccaa gcaattgcac gttagtgcaa ttatggagga ttagctcagc tgggagagca 95401 tctgccttac aagcagaggg tcggcggttc gagcccgtca tcctccacca ttatgccggt 95461 gtagctcaat tggtagagca actgacttgt aatcagtagg ttgggggttc aagtcctctt 95521 gccggcacca cttttatatg atataatact caagtctctt gtagaagagc cattagctca 95581 gttggtagag catctgactt ttaatcagag ggtcgaaggt tcgagtcctt catggctcac 95641 cattttacgc gggtgtggcg gaattggcag acgcgctaga cttaggatct agtgtcttta 95701 tgacgtgggg gttcaagtcc cttcacccgc attatatagg ataacagtta gaaaaactgg 95761 acatcctgtc tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 95821 gggttcgaat cccgtcttcc gctccaacta taccatccac gccggggtgg tggaattggc 95881 agacacacag gacttaaaat cctgcggtag gtgactaccg tgccggttca agtccggccc 95941 tcggcattat gttttgcgcc cgtagctcaa ttggatagag cgtttgacta cggatcaaaa 96001 ggttaggggt tcgactcctc tcgggcgcgc catatctttt aatagaatag ataggaaatc 96061 gggaagtagc tcagcttggt agagcacatg gtttgggacc atggggtcgc aggttcgaat 96121 cctgtcttcc cgaccatttt tttatggggc cttagctcag ctgggagagc gcctgctttg 96181 cacgcaggag gtcagcggtt cgatcccgct aggctccacc aaaagttttt aaaaaagttg 96241 ttgactttga agaagtgacg ttgtatacta ataaagttgc tttaacaaag cggacaaaca 96301 aaatgatctt tgaaaactaa acaagacaaa acgtacctgt taattcagtt tttaaaaatc 96361 gcacagcgat gtgcgtagtc agtcaaacta ctttatcgga gagtttgatc ctggctcagg 96421 acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg agcttgctcc 96481 ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa gactgggata 96541 actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt caaacataaa 96601 aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt tggtgaggta 96661 acggctcacc aaggcaacga tgcgtagccg acctgagagg gtgatcggcc acactgggac 96721 tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc aatggacgaa 96781 agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa gctctgttgt 96841 tagggaagaa caagtaccgt tcgaataggg cggtaccttg acggtaccta accagaaagc 96901 cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt tgtccggaat 96961 tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc ccccggctca 97021 accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag tggaattcca 97081 cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg cgactctctg 97141 gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag ataccctggt 97201 agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct tagtgctgca 97261 gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac tcaaaggaat 97321 tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc 97381 ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt cgggggcaga 97441 gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc 97501 aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta aggtgactgc 97561 cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg 97621 gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg ttaagccaat 97681 cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg aagctggaat 97741 cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt gtacacaccg 97801 cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt ttaggagcca 97861 gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc gtatcggaag 97921 gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc ttgggtctta 97981 taaacagaac gttccctgtc ttgtttagtt ttgaaggatc attccttcga aacgtgttct 98041 ttgaaaacta gataacagta gacatcacat tcaagtaata caagatatca catagtgatt 98101 ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta ggagccgatg 98161 aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg atccggagat 98221 ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga attcatagga 98281 tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag agaaagcaaa 98341 tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga ggcttgcctc 98401 ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg aagaggtctg 98461 gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc tcctgagtgg 98521 atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc atctcccaag 98581 gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg tgaaaagcac 98641 cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc agagcccgtt 98701 aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatccc gtgcaaggtt 98761 aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg agtacgtggt 98821 cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt aacactgaat 98881 ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta ggggtgaaat 98941 gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct agcctcaagg 99001 taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt taccgaattc 99061 agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt gataagatcc 99121 gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata cgttaagtgg 99181 aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc caccatttaa 99241 agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc ggggctaaac 99301 gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc taagggctgt 99361 gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt atgagtagcg 99421 aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa ggctcgtccg 99481 ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga caacaggttg 99541 atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag gatagggtaa 99601 gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa atccgtttcc 99661 cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga ttccacactg 99721 ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca caggtaggcg 99781 aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca aaatgacccc 99841 gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc gcagtgaata 99901 ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg cgaagtatag 99961 gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa gcgaaggtgc 100021 gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta gcgaaattcc 100081 ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg tctcaacgag 100141 agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag gacggaaaga 100201 ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta caggataggt 100261 aggagccttg gaaaccggag cgccagcttt ggtggaggca tcggtgggat actaccctgg 100321 ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc aggtgggcag 100381 tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt ccctcagaat 100441 ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga gacctacaag 100501 tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa gggccatcgc 100561 tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag tccacatcga 100621 cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag tcggtcccaa 100681 gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg tcgtgagaca 100741 gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct tagtacgaga 100801 ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat cgctgggtag 100861 ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc tcaagatgag 100921 atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat aggtctgagg 100981 tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact taaccatatt 101041 tttgaatgat gtcacatctg ttatctagtt ttgagagaac actctcaatt tgtttggtgg 101101 cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc tcttcagcgc 101161 cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa gcttaaaccc 101221 agctcaatga gctgggtttt ttgtattttg gtttattggt atcataaaat tccacttaac 101281 tgtataatat aataacttta taccgaattt taaatcagca atcaggtttt gtggaccggg 101341 aaaatggaaa taatgaagga tagagcgaga aagttgaaaa ttctcgagaa acggcttata 101401 gtaagattaa agtcaaatat agtcaaagtc agtaaaggag ggggttgagt gggacataat 101461 atttctgaca tcattgaaca atatttaaaa cgagtgttag atcaaaatgg caaggaaatt 101521 ttagagatta aacgaagtga aattgcagat aaatttcaat gcgttccttc ccaaataaat 101581 tatgtcatca acaccagatt tacaagcgaa agaggatata ttgttgagag caaacgcggg 101641 ggcggcggtt acatcagaat cattaaaatt aaaatgaaca atgaagttgt cctgatcaat 101701 aatataattt ctcaaattaa tacccatttg tctcaagcag cctctgatga cattatttta 101761 aggctattag aagacaaggt aatttcagaa agagaagcaa aaatgatggt cagcgtaatg 101821 gaccgctcag ttttacacat tgacttacct gaacgtgatg aattaagagc gagaatgatg 101881 aaggcaatgc tgacttcttt aaaattaaaa taagcgggtg aaaagattga tttgtcaaga 101941 gtgccacgag agaccagcca cttttcactt tacaaaggtt gttaacggag aaaaaataga 102001 agttcatatt tgtgaacaat gtgccaaaga aaatagtgat tcatatggta taagtgcaaa 102061 tcagggtttc tctattcata atttactttc gggtttactg aacatggatt cttcatttca 102121 aaatgcagga actcaaatgt tcagtcactc ggagcaaata tctgcttgtc cgaaatgcgg 102181 aatgactttt cagcaattca gaaaaattgg ccgttttgga tgttctgaat gttacaaaac 102241 atttcatagc aacattacac caatcctacg taaagtgcac agcggaaaca ctgtgcatgc 102301 aggtaagata ccgaaacgaa taggcggcaa tcttcatgtc agacggcaga ttgatatgct 102361 aaaaaaggaa ttagaatcct taatccatca agaagaattt gaaaatgcag ctcatgtaag 102421 agatcaaatt cgtttattag aacaatcact caaaagtaca gatagtgagg aggaacagga 102481 gtaatgtcgc taaagcattt tattcaggac gcactaagca gttggatgaa gcagaaagga 102541 cctgaaagtg acattgtact cagcagccgc atacgtttag caagaaactt tgagcatatt 102601 cggttcccta cgcggtattc caatgaagaa gcctcatcca tcatacagca atttgaagat 102661 cagttttcag agcaagaaat tcccggaatc ggcaaatttg ttttgattag aatgaatgat 102721 gcacagcctt tagaaaagcg tgtacttgtt gaaaaacatc taatcagccc gaatttgaca 102781 gagtctcctt ttggcggctg tttgctttct gaaaatgagg aagtaagcgt catgctaaat 102841 gaagaggacc atattagaat tcagtgtctt ttccctggat ttcagctttt agaagcaatg 102901 aaagccgcaa accaggtcga cgactggatt gaagaaaaag ttgattatgc attcaatgag 102961 caaagaggat acttaaccag ctgtcctaca aacgtaggta ctggtttaag ggcttcggtc 103021 atgatgcatc tgccggcgct ggttttaact aggcaaataa atcgaattat accggcaatt 103081 aatcaattag gcttagttgt tagaggaatt tatggggaag gcagcgaagc agtagggaat 103141 atctttcaaa tttcaaatca gatcacgctt ggtaagtcag agcaggatat tgtagaggat 103201 cttaacagtg ttgctgctca gttgattgaa caagaacgat ctgcccgaga agcgatttat 103261 caaacttcta aaatcgaact tgaggatcgg gtatatcggt catatggggt cttgtctaat 103321 tgccggatga tagaatcgaa agaaactgca aagtgccttt cagatgttcg gttaggcata 103381 gacttaggca taataaaagg actttcaagc aacatactta acgaacttat gattttgacg 103441 cagccagggt ttttacagca atactcggga ggcgctttgc gaccgaacga aagggacatt 103501 cgaagagcgg ctctcatcag agaacggctt cacttagaaa tgaatgggaa aagacaggag 103561 gatgaatcga tatgatgttt ggaagattta cagaacgagc tcaaaaagta ctggcgctag 103621 cacaggaaga agcacttcgg ttaggtcata ataacattgg cactgagcat attttattag 103681 gactggtaag agaaggagag ggcattgctg ctaaagctct tcaagcgctt ggactcggtt 103741 cagaaaaaat tcagaaagaa gtagaaagtt tgatcgggcg cgggcaggaa atgtctcaaa 103801 cgattcatta tactcctaga gctaaaaaag tcattgagct ttcaatggat gaggcaagaa 103861 aactcggtca ttcttatgtg ggaacagaac atattcttct tggtctgatt cgtgaaggag 103921 aaggtgttgc tgcgagagtt ctgaataatc tcggtgtcag cttaaataaa gcaagacagc 103981 aggtgctcca gcttctagga agtaatgaaa caggatcatc agcggcagga acaaacagca 104041 atgcgaatac gcctacgctt gacagcttgg caagagactt aactgctatt gcgaaggaag 104101 acagccttga ccctgtaatc ggcagaagca aggagatcca gcgtgtcatt gaagtgttaa 104161 gccgcagaac gaaaaacaac cctgttctca ttggggaacc aggtgtaggt aaaacggcta 104221 tcgcagaagg tttggcacag caaattatca ataatgaagt acccgaaatt ttgcgtgata 104281 aacgtgtgat gacattagac atgggaacag ttgttgccgg cacaaaatac cgcggagaat 104341 ttgaggatcg cctgaagaag gtcatggatg aaattcgcca ggcaggaaat atcattctat 104401 tcatcgatga gctccataca ttaatcgggg caggcggagc agaaggtgct attgatgcat 104461 ctaatatttt aaaaccttca cttgctcgtg gcgaactcca atgtattggt gcaacgactc 104521 ttgatgagta ccgtaaatat attgaaaaag atgcagcact ggaacgccgt tttcagccga 104581 ttcaggttga tcagccatct gtagatgaaa gtattcaaat tttacaaggt ctgcgtgaca 104641 gatacgaagc ccaccaccgc gtttctatca ctgatgatgc cattgaagct gcggttaagc 104701 tttctgacag atatatttct gaccgcttcc ttccggataa agcaattgac ttgatcgatg 104761 aagcgggttc aaaggtgaga ctgcgctcat ttacaacgcc tcctaactta aaagagcttg 104821 agcagaagct tgatgaggtt cgtaaagaga aggatgcggc agtgcaaagc caagagtttg 104881 aaaaagctgc ttccttgcgt gatactgaac aacgcctgcg cgagcaagta gaggatacga 104941 agaaatcatg gaaagagaag caagggcagg aaaactcaga ggttactgtg gatgatattg 105001 cgatggttgt atccagctgg accggtgtgc ctgtatctaa aatcgcccaa actgaaactg 105061 ataagcttct caatatggaa aacattcttc actcccgtgt catcggccag gatgaagcag 105121 ttgtagcggt tgcaaaagcc gtcagacgtg caagagcagg attgaaagat cctaaacgcc 105181 caatcggctc attcattttc ttaggcccta caggtgtagg taaaacagaa cttgcacgag 105241 cacttgctga atccattttt ggcgatgaag aatccatgat cagaattgat atgtctgaat 105301 acatggaaaa acattcaact tcaagacttg ttggttcacc tccgggttat gtgggatatg 105361 atgaaggcgg tcaattgaca gagaaagtca gaagaaaacc ttactctgtc gtgcttcttg 105421 atgagatcga gaaagcgcac cctgatgtct tcaatatcct tctgcaagtt cttgaagacg 105481 gacgattgac tgattctaaa ggacgcacag tcgatttccg caataccatt ctgatcatga 105541 catcaaacgt cggagcaagt gagctaaaac gcaataaata tgtcggcttt aacgttcagg 105601 atgaaactca aaatcataaa gacatgaaag ataaagtgat gggtgaatta aaacgagcgt 105661 tcagacctga gttcatcaac cgtattgatg aaatcattgt cttccattca cttgagaaaa 105721 aacatctcac tgagattgtg tcattaatgt ctgatcaatt aacgaaacgc ctgaaagaac 105781 aagatctttc tatcgaattg acagatgctg caaaagcgaa agtcgcggaa gagggcgttg 105841 acctggaata cggtgcccgt ccgttaagaa gagcgatcca aaaacatgtc gaggatcgtt 105901 tatctgaaga actcctcaga ggaaatattc ataaaggaca gcatattgtt cttgatgtag 105961 aagatggcga atttgtcgta aaaacgactg ctaaaacgaa ttaatataga agacggaaat 106021 gaggcataca gcatgtaagt gtatgcctca ctttcatatc aagaaataga acaagggaga 106081 ggtcttacac tatatatggc taaaacaaaa tcgaagttca tctgccaatc ctgcggctac 106141 gagtctccaa aatggatggg gaaatgtccg ggctgtggtg cttggaatac aatggtggaa 106201 gaaatgatta aaaaagcacc ggccaatcgg agagcggctt tttctcattc tgttcaaact 106261 gtacagaaac cttcacctat tacatcaatc gaaacatcag aagaaccccg cgtcaaaacc 106321 cagcttggcg agtttaacag agtactcggc ggaggtgtcg ttaaaggctc cctcgtttta 106381 attggcggtg atcctggtat cggaaagtca acgctattac tgcaggtttc cgctcaatta 106441 tcaggctcat caaacagtgt cctgtatatt tcgggagaag aatctgtaaa gcaaacgaag 106501 ctgcgagcag accgtctcgg cattaataat ccgtcactgc atgttttatc tgaaaccgat 106561 atggagtata tttcgtctgc tatacaagag atgaatccat cgtttgtcgt tgttgactct 106621 attcaaacgg tttaccaaag cgatattaca tctgctccag gcagtgtgtc acaggtcaga 106681 gaatgtaccg ctgagctgat gaaaattgca aaaacaaaag gtattccgat ttttatcgta 106741 gggcacgtga cgaaagaagg gtctattgca ggtccgagac tgttggagca tatggttgac 106801 actgttttat attttgaagg agaacgccac catactttcc gtattttgcg ggctgtaaaa 106861 aaccgtttcg gatctacaaa cgaaatgggc attttcgaaa tgcgggaaga ggggctcact 106921 gaggttttga atccttcgga aattttctta gaagaacgct ctgctggttc cgcaggctcg 106981 agtatcactg cctctatgga gggcactaga ccgattctcg ttgaaattca ggcactcatc 107041 tcgccaacaa gttttggcaa cccaaggcgt atggcaacgg gaatagacca taacagggtt 107101 tctctgttaa tggctgtgtt agaaaaaaga gttggactgc tgctgcaaaa tcaggatgct 107161 tatttgaaag tggctggcgg cgttaagctt gatgaaccgg caattgatct tgcgattgtg 107221 attagtattg catcaagctt tagagacaca cctccaaatc ctgcagattg ttttattgga 107281 gaagtgggat taaccggaga agtccggcgg gtttcaagaa ttgaacagcg tgtgaaagaa 107341 gcggcaaagc ttggttttaa acgcatgatc atacccgcgg caaatctgga tggatggaca 107401 aaaccaaaag ggattgaggt tatcggagta gcaaatgttg cagaagcgct tcgtacttca 107461 ttaggaggat aatagatgga aaaagagaaa aaaggggcga aacacgagtt agacctgtca 107521 tctatattgc agtttgttgc tccgggtaca ccgctcagag cggggatgga aaacgtcttg 107581 agagcaaata caggcggtct gattgttgtt ggatataatg ataaagtaaa agaagtggtg 107641 gacggcggct ttcacataaa cacggctttt tctccggcgc atttatatga gctggctaaa 107701 atggatggag cgatcatttt aagtgattct ggtcaaaaga tcctatacgc gaatactcag 107761 ctgatgccgg atgccacaat ttcttcatca gaaacaggaa tgcggcacag aactgccgaa 107821 agagtagcta agcaaactgg ctgtcttgta atcgccattt ctgaaagaag aaatgtcata 107881 acgttatatc aggaaaacat gaagtataca ctaaaagaca taggatttat tttaaccaag 107941 gcgaaccaag ccattcaaac acttgaaaaa tataagacaa tcctcgataa aacgattaat 108001 gcactgaacg cgttagagtt tgaggaactt gttaccttca gtgatgtctt gtctgtcatg 108061 catcgttatg aaatggtact gagaatcaaa aacgaaatta atatgtatat caaagagctg 108121 gggacagaag ggcatctgat caaactgcaa gtcattgaat tgattacgga tatggaagaa 108181 gaggccgctt tatttattaa ggactatgta aaagaaaaga ttaaagatcc gtttgttctc 108241 ttgaaggagc tgcaggatat gtccagttat gatctgctgg atgattccat tgtgtataag 108301 cttctcggtt accctgcttc tactaatctt gatgattatg tattgccgag aggatacagg 108361 ctgttaaata agataccgcg tcttccgatg ccgattgttg aaaatgttgt agaagcattt 108421 ggagtcctgc caaggattat tgaggcgagt gcagaagaat tagatgaagt agagggaatc 108481 ggtgaagtac gagcccaaaa aatcaaaaaa ggattaaaac gcctgcaaga gaagcattat 108541 ttagacagac aactgtgatt tcggttaaaa ccttatgaat acgggtatat taatgttggt 108601 ttttgtttat tctgatattc gtaggatgca taagactttg tgaaattaaa atgttaaaaa 108661 aggaggtggg ggtatgttaa aacgaatagt tcaggcgttc ttcattattt ttggcggcgt 108721 tgttggtata tttttgatac ctgaattgtt tgtactgtta aatatacagg acataccttt 108781 aataacaaac gcatatacgt ctgcggcaat aggagcaatt atcttttttc tcatcagtat 108841 atggggtaca gaatacgttg tgaactgggt gaagtggata gaggattcat tgttaaaagc 108901 gccggttcca gatttgttat ttggaagtct tggcttagtt tttggactta taattgctta 108961 tcttatcgta aatgttattc ctttagacaa tataccttac cgcatattca gcacaataat 109021 tcctgtattt ttggctttct tcctcggtta tctcggcttc caggtgggct ttaagaaaaa 109081 ggatgaattg atcagcctgt tttccatttc cgccagaatg caaaagaaaa aaggaacagc 109141 tgatgaagaa catgaggttc aagacaagaa gctgaaaatt ttggacacta gtgttattat 109201 tgatgggaga atagcagata tttgtcagac tggtttttta gagggagtta tcgtgattcc 109261 gcagtttgtc cttgaggaat tgcagcatat tgcagactct tcagatgttt taaaacgaaa 109321 cagaggacgc cgcggtcttg atatcctgaa ccgcattcag aaagaattag acattgaagt 109381 tgaaatttac gaaggcgact ttgaagatat tcaggaggtt gacagcaagc tcgtcaaact 109441 tgctaagctg acatccgggg tcgttgtgac gaatgatttt aatttaaata aagtgtgcga 109501 gcttcagaag gtagcagtat taaacattaa tgaccttgcc aatgcggtta agcctgttgt 109561 gcttcctggc gaggaaatga atgttcaggt cattaaggac gggaaagagc ataatcaggg 109621 agttgcctac ttggatgacg gtacgatgat tgtcgttgaa gaaggacgga attatatcgg 109681 caagcatatt gatgtactcg tcacaagtgt gctgcagaca gcagcgggac gaatgatttt 109741 tgcgaagcct aagctgttgg agaaggcgct gtaaagggag aagaaacaat gagttatgat 109801 gtggtgattc ctgcagccgg acagggaaag cggatgaagg cagggagaaa taaactgttc 109861 attgagctga agggagaccc ggtgatcata cacacgttaa gagtgtttga cagccaccgg 109921 cagtgcgata aaatcatttt ggtgattaac gagcaggagc gggagcactt tcagcaattg 109981 ctgtccgatt acccgtttca aacttcaatt gagcttgttg caggcggaga tgagcgacag 110041 cacagtgtgt ataaggggct gaaagccgta aagcaggaaa agattgtcct tgtacatgac 110101 ggtgcccgtc catttataaa acatgaacaa attgacgaac tgatcgcaga ggcggaacag 110161 acaggagcgg ccatccttgc tgttccggta aaagatacga ttaaacgcgt tcaagattta 110221 caagtcagtg agacgattga acgttcaagc ttgtgggctg tccaaacgcc acaagctttt 110281 cgtctttctt tattgatgaa ggctcacgct gaggccgagc gcaagggatt tttagggacg 110341 gatgacgcca gcctcgttga acagatggag ggcggttcgg tccgtgttgt agaaggcagc 110401 tatacaaata ttaagctgac gacgccagac gatttgacgt cagctgaagc tatcatggaa 110461 tcagaaagtg ggaataaaca tgtttagaat tggacaagga tttgatgtgc atcaattagt 110521 ggagggccgt cctctcatta ttggcggaat tgaaatcccg tacgaaaaag ggctgcttgg 110581 ccattctgat gcagacgtat tgttgcatac cgtcgctgac gcctgcctgg gagctgtggg 110641 tgaaggagac ataggcaagc attttcctga cacagatccc gagttcaagg acgcagattc 110701 tttcaaatta cttcagcatg tctggggaat cgtgaaacag aaggggtatg tccttgggaa 110761 cattgattgc accatcatag cgcaaaagcc gaagatgctg ccgtacatag aagatatgag 110821 aaaaagaatt gctgaaggcc ttgaggcaga tgtttctcaa gtaaatgtaa aagcaacaac 110881 gacagaaaag cttggattta caggccgggc ggaaggaata gcggctcagg cgacagtact 110941 gatacaaaaa ggctaacttg ttttgatgcc gggtctattt ggtggtagaa tagattcata 111001 catttttgcc tgaggccata catgacatga aaggaagtat ttgaaaatgg gaaacgaagt 111061 acgcgtccgt tatgcaccga gtccaaccgg acatttgcat attggaaatg ccagaacggc 111121 gctttttaat tatttatttg cccgcaatca aggcggtaag tttatcattc gagttgagga 111181 tactgataaa aagcgcaata ttgagggcgg agaacaaagc cagctgaatt atctgaagtg 111241 gctaggtatt gactgggatg agagtgtgga tgtcggagga gagtacggtc cataccgtca 111301 gtcagagcgt aacgatatct ataaagtgta ctatgaagag cttcttgaaa aagggcttgc 111361 ttataaatgt tactgtacgg aagaagagct tgaaaaagag cgtgaagaac agattgcccg 111421 cggagaaatg cctcgttatt ccggaaaaca cagagacctg actcaggaag aacaggagaa 111481 atttatcgcc gaaggcagaa aaccaagtat tcgtttccgt gtgccggaag gaaaagtcat 111541 cgccttcaac gacatcgtaa aaggcgaaat ttcttttgaa tcagatggca tcggcgactt 111601 cgttattgtg aaaaaggacg gaacgcctac ttataacttc gcggtagcta ttgatgacta 111661 cttaatgaaa atgacacacg tgctgcgcgg tgaggatcat atttctaaca caccgaaaca 111721 gattatgatc tatcaagcat tcgggtggga tattcctcag ttcggacaca tgacgctgat 111781 tgtaaacgaa agccgtaaaa agctcagcaa acgtgatgaa tccattattc aattcatcga 111841 gcagtacaaa gagcttggct acctgccaga agcgctgttc aactttatcg gcttgttagg 111901 ctggtcaccg gttggagaag aagagctttt cacaaaagag cagtttattg aaatttttga 111961 tgtaaatcgt ttatctaaat caccagcttt gtttgatatg cataagctaa aatgggttaa 112021 caaccaatat gtgaagaagc tggatcttga tcaggttgtt gaactgacgc ttccgcattt 112081 gcaaaaagcc ggcaaagttg gcactgagct ttctgctgaa gaacaagaat gggttcgtaa 112141 actgatttcc ctgtatcatg agcaattaag ctacggtgcg gaaattgttg agctgactga 112201 tttgttcttt acggatgaga tcgagtataa tcaagaagcg aaagctgttc tggaagaaga 112261 acaggttcct gaagtgctca gcacattcgc agcgaagctt gaagagcttg aggagttcac 112321 tccggataat atcaaagcat cgatcaaagc agtgcagaaa gaaactggcc ataaagggaa 112381 aaaactgttt atgccgattc gtgttgctgt aacagggcaa actcacggtc cggaactgcc 112441 gcaatcaatt gaattgatcg gtaaagagac tgcaattcag cgtttaaaga atatctaaat 112501 aaatgattgt tgacagggaa gagtataaag ctttaggcca ttacagaaag gatcttcatt 112561 ggctgagaga gatccatgag ccgggtttta gaagtgcgcc cttaagacct ttgaagaacg 112621 ttttttgaaa tcagtattca aaggcggccg ccgccgttac aggctgaagt tgggagagca 112681 gaagtctgct tttcaaacag agtggaaccg cgcggttaaa gcgtctctgt catgtttaca 112741 tgcagagacg ctttttttat tgggtagagg aaatcagata gagaaacggg gggaagcatg 112801 tgttttttag aatgctcaaa gaagacattg atactgtgtt cgatcaagat cccgcagcaa 112861 gaagctattt tgaagtgatt ttaacttatt ccggtttaca tgctatatgg gcgcatcgga 112921 ttgcacatgc tttatataaa cgaaaatttt atttccttgc acgccttata tctcaagtaa 112981 gccgattttt taccgggata gaaatccacc ccggcgctac aatcgggaga agatttttca 113041 tagaccacgg catgggggtt gtcattgggg agacatgtga aatcggcaat aacgtaaccg 113101 tttttcaggg ggttaccctc gggggaacgg gaaaagaaaa gggaaaaagg cacccaacga 113161 ttaaagatga cgcattgata gccacaggtg ctaaagtgct cggttctatt acggtcggtg 113221 aaggctcaaa gattggcgct ggttcagtag tgctgcatga tgttcctgat ttttcaacag 113281 ttgtcggtat ccctggacgg gtcgttgtac aaaatggcaa gaaagtaaga cgcgatttaa 113341 accatcagga tttgcccgat ccagttgctg accgctttaa gtctttggaa cagcagattt 113401 tagagctgaa ggcagaactt gaagacagaa aagaaaggat caatcaaaaa tgacaatcac 113461 actttataat acattgacta gacagaagga aacattcgtt cctcttgaag agggaaaagt 113521 gaaaatgtat gtatgcggac ccacggttta caattacatt catatcggga acgcgcgtcc 113581 ggcaatcgtt tacgatacgg ttcgaaacta tttagagtat aaaggctatg atgtgcagta 113641 tgtctctaac ttcacagacg tagacgataa attaattaaa gcggcaaatg aactcggtga 113701 ggatgtaccc accatttcag agcgttttat taaagcatac tttgaagacg taggtgcgct 113761 cggctgccga aaagccgacc ttcatccgcg agtaatggag aacatggatg ccattatcga 113821 attcgtagat cagctcgtga aaaagggcta cgcatatgaa tcagaaggtg acgtatattt 113881 caaaaccaga gcatttgaag ggtacggaaa gctttctcag caatcaatcg atgaactaag 113941 atcaggtgca cgcatccggg tcggcgagaa aaaagaagat gctcttgatt tcgcactgtg 114001 gaaagcggca aaagaaggag aaatctcttg ggatagccct tgggggaaag ggcgtccggg 114061 ctggcacatt gaatgctcag caatggtgaa aaagtatctc ggtgaccaga ttgatatcca 114121 tgcgggcgga caggatttaa cattccctca ccatgaaaac gaaattgcgc aatctgaggc 114181 gctgacaggc aaaacgtttg cgaagtactg gcttcataat ggttatatca atattgataa 114241 tgaaaaaatg tcaaaatcac taggcaactt tgtgcttgtg catgacatca ttaaacagca 114301 tgatccgcag cttttgagat tctttatgct atctgttcat tatcgccatc cgattaacta 114361 ttcagaagag cttctggaga atacgaaaag cgcgttcagc cgtttaaaaa cagcgtacag 114421 caatcttcag caccgtctga acagcagtac gaatttaacc gaagatgacg atcaatggct 114481 tgaaaaggtt gaagaacacc gcaaagcatt cgaagaagag atggacgatg attttaatac 114541 ggcgaatgcc atttcagtct tgtttgactt agcgaaacac gccaattatt atcttcagaa 114601 agatcatacg gctgatcatg tgattacggc gtttattgag atgtttgacc gcattgtttc 114661 tgtcctcggt ttttcgttgg gtgagcagga acttctcgat caagagattg aagacttaat 114721 cgaaaagcga aatgaagcgc gccggaatcg cgattttgca ttgtcagacc agatccgcga 114781 ccagctgaaa agcatgaata tcattcttga agatacggct caaggcactc gctggaaacg 114841 gggagaataa cagatgcttg aatttgatac gataaaagat tctaagcagc ttaacggtct 114901 tgcgcttgct tatataggtg atgccatttt tgaagtgtat gtcaggcatc acctgcttaa 114961 gcagggcttt accaaaccaa atgatcttca taagaaatca agccggattg tttcagcaaa 115021 gtcacaggct gagatcctat tttttctgca gaatcaatca ttttttacgg aagaagagga 115081 agcggtgctg aaaagaggca gaaatgccaa gtcagggaca acacctaaaa atacagatgt 115141 tcagacgtac cgctacagta cagcatttga agcgcttctg ggctaccttt ttctagagaa 115201 aaaagaggaa cgacttagtc agctcgtagc cgaagctata caattcggga cgtcagggag 115261 gaaaacaaat gagtcagcaa catgattacg tcatagggaa aaatgcagtg atcgagacgt 115321 taaaatctga tcggaagctg tataagctgt ggatggcgga aaacaccgta aagggacaag 115381 cacagcaagt gattgagctt gccaaaaagc agggaatcac gattcaatac gtcccgagaa 115441 aaaaactcga tcaaatggtg acaggacagc atcagggcgt agtggcacag gttgcagcgt 115501 atgaatatgc agaactggac gatttatata aagcagccga agaaaaaaat gaacagcctt 115561 tcttcctcat tctggacgag cttgaagacc ctcataatct tggttccatt atgaggacag 115621 cagatgcggt cggcgctcat ggcatcgtca ttccaaaacg gagagctgtc gggctgacaa 115681 caacagtggc aaaagcttca acaggagcaa ttgagcacat tcctgtagca agagtcacca 115741 atttggcacg gacgttagaa gagatgaaag agcggggaat ctgggttgtc ggaacggatg 115801 cgtccgcgcg tgaggatttc cgtaatatgg acggcaatat gcctttggct ctagtcatcg 115861 gaagtgaagg aaaagggatg ggccgccttg tgaaggaaaa gtgcgatttt ctcattaaac 115921 tcccgatggc cggaaaggta acttcactaa atgcatctgt cgcggctggt cttttgatgt 115981 atgaagtcta ccggaaacga aaccctgtgg gagaataaag acccatggat atcctgttag 116041 tagacgggta caacatgatt ggagcctggc cgcagctgaa ggatttaaaa gcgaacagtt 116101 ttgaagaggc gagagacgta ctgattcaga aaatggcgga atatcaatcg tatacaggaa 116161 acagggttat tgttgttttt gacgcgcatc tcgtaaaagg gcttgagaaa aaacagacca 116221 accatagagt tgaagtaatt tttacaaaag aaaatgagac ggctgatgag cggatagaaa 116281 agctcgctca ggctttgaat aatattgcga ctcaaattca cgttgcgacc tctgactata 116341 ctgagcagtg ggcgattttc ggacaggggg cattgcggaa atcggcccgg gagcttctga 116401 gagaggtaga aacgattgaa aggcgaatag agagacgggt aagaaaaatc acttccgaaa 116461 agccggcggg taaaattgct ttatcggaag aggttttgaa aacgtttgaa aagtggaggc 116521 ggggagactt agattaagtt gacgcttttt tgcccaatac tgtataatat ttctatctac 116581 gtgcgccggg gggatcggag tgaatctaca gaacaacaag ggaaaattca acaaagagca 116641 gttttgccag ttggaggacg agcaggtcat tgaaaaggtt catgttgggg acagtgatgc 116701 gttagattac ttgattacga agtaccgaaa ctttgttcgg gcaaaagcaa gatcctattt 116761 cttaataggg gcggacagag aggatattgt tcaggaaggc atgataggcc tctataagtc 116821 tattcgtgac ttcaaagagg acaagcttac ctcattcaaa gcttttgcag aattatgtat 116881 tacccgccaa attattaccg caataaagac agctactcgc cagaaacaca ttcctttgaa 116941 ttcctacgcc tcattagata aaccgatctt tgatgaagaa tcagaccgaa cgctgctgga 117001 tgtcatttca ggagcgaaaa ccttaaatcc tgaggaaatg atcattaatc aggaagaatt 117061 tgatgatatt gaaatgaaaa tgggagaact attaagtgat ttagagagaa aagtactcgt 117121 cttatatctc gacgggagaa gttaccaaga gatttctgat gaactgaacc gacatgtgaa 117181 atcgatcgac aatgcccttc agcgtgtgaa acgcaagctg gagaagtact tggaaattcg 117241 cgaaatcagt ttgtaatagg aatttatgct atattgacag tatttttctg actatgatat 117301 gttactaaag ataagaacta atgtctattt agaaaaaggt gtaatgacat gagaaaaaag 117361 attacgttag catgcaagac atgcggaaac cgtaattata cgacaatgaa gagctctgca 117421 tcagcggctg agcgattaga agtaaagaaa tactgcagta cttgcaattc acatacagct 117481 catcttgaaa caaaatagtt tttgcgcttt taaattgtgg aggtctttta catgcgtatt 117541 atgaaattct ttaaagatgt tgggaaagaa atgaaaaagg taagctggcc taaaggaaaa 117601 gagttaacgc gttataccat tacggtaatt tcaacagtta tcttttttgt tatctttttt 117661 gccctccttg acacaggaat ttctcaatta attcgtttaa tagttgaata atgatcagca 117721 atacgtgcta taatagatca taatattact tgccaaaacc cgttcagcgg gttttttatt 117781 gtggcttaaa atgaaagtta tcataggctt gccgcctatt ttttgaagcg ttatggtaat 117841 tcactaaaac caaatgcggg gagggaagga ctggacagtc ctgaatagaa tggaaaagaa 117901 ttggtatgtt gttcacacgt actctggtta tgagaataaa gtaaaagcca acttggaaaa 117961 gcgtgttgaa tcaatgggga tgcaggataa aattttccgt gtagtcgtac ccgaagaaga 118021 agaaacggat atcaaaaacg gcaagaaaaa agtcgtgaaa aagaaagtat tccctggtta 118081 tgtgcttgtt gaaattgtaa tgacagacga ctcttggtat gtcgtccgca acacgccggg 118141 cgttactgga ttcgtaggat ctgccgggtc aggttcaaaa ccgacgccgc ttcttccggg 118201 ggaagcagaa accattctga agagaatggg catggatgaa cgaaaaactg atattgactt 118261 tgaactgaaa gagacagtga aagtaataga cggacctttt gctaacttta caggatcaat 118321 tgaagagatt gattatgata aaagcaaggt caaagttttc gttaatatgt ttggccgtga 118381 aacgccggtt gagctggaat ttacccaaat cgataaattg taatgtgaaa aaacttgaaa 118441 ttgctatata taaatgataa tatagcaaag gtacgtcttg gacttatcca aggcaactag 118501 catgatattt cgtcattcat ataaagaatg aaaccttgag tgggagggtt taccctatta 118561 ccacatcacg gacttaagga ggtgtgtctc gtggctaaaa aagtagttaa agttgtaaaa 118621 ttgcaaattc ctgctggaaa agctaaccca gcaccaccag ttggacctgc acttggtcaa 118681 gccggtgtta acatcatggg attctgtaag gagtttaacg ctcgtacagc tgaccaagct 118741 ggtttaatca ttcctgttga aatttcggtt tacgaagacc gttcatttac atttattaca 118801 aaaactccac ctgctgcagt attgcttaaa aaagcagctg gaattgagtc tggttctggt 118861 gaaccaaacc gtaataaagt ggcaaccgtt aagcgcgata aagtacgcga aatcgctgaa 118921 acgaaaatgc ctgacttaaa cgcagcagac gttgaagcgg caatgcgcat ggttgaaggt 118981 actgcccgca gtatgggtat tgtaatcgag gattaatttg tttcttgtcg ggttgcgagt 119041 tttaacaagt tcgcaaccct tattcgtggg aggttattcc gctataacca cataaggagg 119101 aaattttaaa atggctaaaa aaggtaaaaa gtacgttgaa gctgctaagc ttgtagaccg 119161 ttctaaagct tacgacgtct ctgaagcagt agctctcgtt aaaaaaacaa acacagctaa 119221 attcgacgct acagttgaag tggctttccg tttaggggtt gaccctcgta aaaacgacca 119281 gcaaatccgt ggagcagttg tgcttccaaa cggaactggt aaaactcagc gcgttctcgt 119341 tttcgcaaaa ggcgaaaaag cgaaagaagc tgaagctgct ggtgcagatt tcgtaggcga 119401 tactgactac atcaacaaaa ttcaacaagg ctggttcgat ttcgatgtta tcgtagctac 119461 acctgacatg atgggtgaag ttggtaaaat cggtcgtgta cttggaccaa aaggtttaat 119521 gccgaaccct aaaactggta cagttacttt cgaagttgaa aaagctatcg gcgaaatcaa 119581 agctggtaaa gttgaatacc gcgttgataa agctggaaac attcatgttc ctatcggtaa 119641 agtttctttc gaggatgaaa aacttgttga gaacttcaca acaatgtacg atacaatcct 119701 taaagctaaa cctgctgcag ctaaaggcgt ttacgtgaaa aacgttgctg taacttctac 119761 tatgggacct ggtgtcaaag tagactcttc aacttttaac gtaaaataat attgacatga 119821 catcaacatt ctgatattat tcaaaatgtt gtaaaataga atatcattta taccgtagac 119881 agtaggggcc taaccgctta attatcctac cgaggtgtat attatcacag ctattacgtt 119941 acgtatgctt gtatatacag cctccatgtc tcatggaggc tttttatatg gaatccgtcg 120001 tctcagtcgt gatcacctaa cggtataagt gttacacaag aatctacagg aggtgtaacc 120061 atgagcagcg caattgaaac aaaaaaagtt gttgttgaag aaattgcttc taaactgaaa 120121 gaaagtaaat caacgatcat cgttgactat cgcggactta acgtttctga agtaactgaa 120181 cttcgtaaac agcttcgcga agctaacgtt gagttcaaag tttacaaaaa tacgatgact 120241 cgccgtgcgg ttgaacaagc tgagcttaat ggtttgaatg atttcttaac tggaccgaac 120301 gcgatcgcat tcagcactga agatgttgtc gctccggcta aagttcttaa tgacttcgct 120361 aaaaatcacg aagctcttga aatcaaagct ggcgttatcg aaggtaaagt ttctactgtt 120421 gaagaagtga aagctcttgc tgaacttcca tcacgcgaag gcttgctttc tatgttgctt 120481 agcgtacttc aagctccagt tcgcaacctt gctcttgctg caaaagctgt ggcagaacaa 120541 aaggaagaac aaggcgctta atctaatcag tttttcataa attaaaacaa aatggaggaa 120601 ttacaaatgg ctttaaatat cgaagaaatc attgcttccg ttaaagaagc aactgtactt 120661 gaattgaacg acctagtaaa agcaatcgaa gaagaatttg gcgtaactgc tgctgctcct 120721 gtagctgtag ctggcggagc tgctgctggc ggagctgctg aagagcaaag cgaattcgat 120781 cttatccttg ctggtgcagg atctcaaaaa atcaaagtta tcaaagttgt acgtgaaatc 120841 actggtcttg gcttgaaaga agctaaagag cttgttgaca acactccaaa accacttaaa 120901 gaaggtattg ctaaagaaga agctgaagag cttaaagcta aacttgaaga agttggcgct 120961 tctgtagaag ttaagtaatc ttcacttacc tgtaggggaa gctcgctttt atgaggcgag 121021 ctttttcttt gccattcttt aagccatgaa aaaaggaggt tctaataatg agtgagcact 121081 attattcaga aaaaccttca gtaaaaagca acaagcaaac ctggtctttt aggcttcgga 121141 ataaagattt cacgtttacc agcgacagcg gggttttttc taaaaaagaa gttgatttcg 121201 gctcccgcct gctgattgat tcttttgaag agcctgaggt tgagggcggc attttagatg 121261 taggctgcgg atacggcccg attggtttat cgctcgccag cgactttaaa gaccggacca 121321 tccacatgat tgacgttaat gagagagccg tagaactatc aaatgaaaat gcggaacaga 121381 acggaataac aaacgttaag atttatcaaa gcgatttgtt ttcaaacgtt gattctgctc 121441 aaacatttgc ttctattctt acaaatcccc caatccgagc cggaaaaaaa gttgtccatg 121501 ctatctttga gaaaagcgct gaacacttaa aagcttcagg tgaattgtgg atcgtcatac 121561 agaaaaagca aggcgcgcct tctgccattg aaaagctcga ggaactgttc gatgaagttt 121621 ccgtcgttca aaaaaagaaa ggctattata tcataaaagc aaaaaaagtt tgactcggta 121681 ttttaactat gttaatattg taaaatgcca atgtatatat tttgcttgat atgatgaatt 121741 gtcaatatct atgtataaat tatacaagta tggaaatgct aataaaatcg gtatttgttt 121801 ttggatgtgg ttttcttaat tagaaaccct tttttctttt gtcttgtaaa agtattttct 121861 ttctttggaa gaaatgctta ttacacatat aatacgcatg atttgagggg tgaatcagtt 121921 gacaggtcaa ctagttcagt atggacgaca ccgccagcgc agaagctatg ctcgcattag 121981 cgaagtgtta gaattaccaa atctcattga aattcaaacc tcttcttatc agtggtttct 122041 tgatgagggt cttagagaga tgtttcaaga catatcacca attgaggatt tcactggtaa 122101 cctctctctt gagttcattg attatagttt aggtgagcct aaatatcctg tagaggaatc 122161 aaaagaacgt gatgtgactt actcagctcc gctaagagtg aaggttcgtt taattaacaa 122221 agaaactgga gaggtaaaag accaagatgt cttcatgggt gatttcccta ttatgacaga 122281 tacaggtact tttatcatta acggtgcgga acgtgttatc gtttcccagc ttgttcggtc 122341 tccaagtgta tatttcagtg gtaaagtaga caaaaacggt aaaaaaggtt ttaccgcaac 122401 tgtcattcca aaccgtggcg catggttaga atacgaaact gatgcgaaag atgttgttta 122461 tgtccgcatt gatcgcacac gtaagttgcc ggttacggtt cttttgcgtg ctctcggctt 122521 cggctccgat caagagattc ttgatctcat aggagaaaac gaatacctgc gaaatacgct 122581 tgataaagat aacacagaaa acagcgacaa agcgttgctg gaaatttacg agcgtctccg 122641 tcctggagag ccgcctacag tagaaaatgc gaaaagcttg cttgattctc gtttctttga 122701 tccgaaacga tacgatcttg ccaatgtagg acgctataaa attaataaaa aacttcatat 122761 taagaatcgc ctcttcaatc agagacttgc tgaaacgctt gttgatcctg aaacaggaga 122821 aatccttgct gaaaaaggcc agattcttga tagaagaacg cttgataaag tactgccata 122881 cttagaaaac ggaatcggtt ttagaaagct gtatccgaat ggcggcgttg ttgaagatga 122941 agtgactctt caatcaatta aaatctttgc tccgactgat caagaaggag aacaggttat 123001 caatgtaatc ggcaatgctt acatcgaaga agagattaaa aacatcacgc ctgctgatat 123061 tatttcttca atcagctact tcttcaacct gctgcacgga gtaggcgaca cagatgatat 123121 cgatcatctt ggaaaccgcc gtttacgttc tgtaggcgag cttctccaga accaattccg 123181 tatcggttta agccgtatgg agcgtgtggt tcgtgagaga atgtcaattc aagatacgaa 123241 tacaattacg cctcagcagc tgatcaatat tcgtcctgtt attgcgtcca ttaaagagtt 123301 ctttggaagc tcacagcttt ctcaattcat ggatcagacg aacccgcttg ctgaattaac 123361 gcacaagcgt cgtctgtcag cattaggacc gggcggattg acacgtgagc gtgccggaat 123421 ggaagtgcgt gacgttcact actcccacta tggccgtatg tgtccgattg aaacgcctga 123481 gggcccgaac atcggtttga tcaactcact atcatcttat gcaaaagtaa accgttttgg 123541 ctttattgaa acgccatatc gccgcgttga ccctgaaaca gggaaggtaa cgggcagaat 123601 cgattactta actgctgatg aagaggataa ctatgttgtc gctcaagcga atgctcgtct 123661 tgatgacgaa ggcgccttta ttgatgacag catcgtagct cgtttccgcg gggagaacac 123721 cgttgtttcc agaaatcgtg tagactacat ggatgtatcg cctaagcagg ttgtatctgc 123781 tgcgacagca tgtatcccgt tcttagaaaa cgatgactcc aaccgtgccc tcatgggagc 123841 gaacatgcag cgtcaggctg tgcctttgat gcagccggaa gcgccatttg ttggaactgg 123901 tatggaatac gtatcaggaa aagactctgg tgccgctgtt atttgtaaac accctggtat 123961 cgttgaacgc gtagaagcca aaaacgtttg ggttcgccgt tatgaagaag tagacggtca 124021 aaaagtaaaa ggaaacctgg ataaatacag cctgctgaaa tttgtccgct ctaaccaagg 124081 tacgtgctac aaccagcgtc cgatcgtaag tgtcggcgat gaagtggtaa aaggagaaat 124141 ccttgctgac ggtccttcta tggagcttgg tgaacttgca cttggccgta acgtaatggt 124201 cggcttcatg acgtgggatg gctacaacta tgaggatgcc atcatcatga gtgaacgcct 124261 agtgaaggat gatgtttata catctatcca cattgaagaa tacgaatcag aagcacgtga 124321 tacgaaactt ggacctgaag aaatcactcg cgatattcca aacgtcggtg aagatgcgct 124381 tcgcaatctt gatgaccgcg gaatcatccg tattggggca gaagtaaaag acggagatct 124441 tcttgttggt aaagtaacgc ctaaaggcgt aactgaactg actgccgaag aacgccttct 124501 tcacgccatc tttggcgaga aagcccgcga ggttcgtgat acttctcttc gtgtgcctca 124561 tggcggcggc ggaattatcc atgacgttaa agtcttcaac cgtgaagacg gagacgaact 124621 tcctccaggt gttaaccagt tagtacgcgt atatatcgtt cagaaacgta agatttctga 124681 aggggataaa atggccggtc gtcacggtaa caaaggtgtt atctctaaga ttcttcctga 124741 agaggatatg ccttaccttc ctgacggcac accaattgat atcatgctta acccgctggg 124801 cgtaccatca cgtatgaaca tcgggcaggt attggaactt cacatgggta tggccgctcg 124861 ttaccttggc attcacattg catctcctgt atttgacgga gcgcgagaag aggatgtctg 124921 ggaaacactt gaagaagccg gcatgtctcg tgacgccaaa acagtgcttt acgacggacg 124981 tactggagag ccgtttgata accgtgtatc tgtcggtatc atgtacatga tcaaactggc 125041 tcacatggtt gacgataaac ttcatgcacg ctctacaggc ccttactcac ttgttacgca 125101 gcagcctctt ggcggtaaag cgcaatttgg cggacagcgt tttggtgaga tggaggtttg 125161 ggcacttgaa gcttacggtg cggcttacac tcttcaagaa attctgactg ttaagtctga 125221 tgacgtggtt ggacgtgtga aaacatacga agccatcgtt aaaggcgaca atgttcctga 125281 accaggtgtt ccggaatcat tcaaagtatt aatcaaagaa cttcaaagct taggtatgga 125341 tgtcaaaatc ctttctggtg atgaagaaga aatagaaatg agagatttag aagacgaaga 125401 agatgcgaaa caagctgacg gcctggcatt atcaggtgat gaagagccgg aagaaacagc 125461 atctgcagac gttgaacgcg atgtagtaac aaaagaataa tctctagtta taaaggcaag 125521 tgacatcggt taatccgaag ataaaaaggg aggtaggccc cttgctagat gtgaacaatt 125581 ttgagtatat gaacatcggt cttgcttcac cagataaaat ccgttcatgg tcttttggtg 125641 aagtgaaaaa gcctgaaacg ataaactatc gtacgttaaa acctgaaaag gacggtctat 125701 tctgcgaacg cattttcgga ccgactaagg actgggaatg tcattgcggg aagtacaagc 125761 gagttcgtta taaaggcgta gtttgtgacc gctgcggagt cgaagtaaca cgggctaaag 125821 tccgtcgtga gagaatgggg cacattgaac tggctgcccc agtttcccac atttggtatt 125881 tcaaaggtat tccaagccgt atgggtcttg tgctggatat gtcacctcgt gctttagaag 125941 aagtcattta ctttgcttct tacgttgtaa ctgatccggc gaatacaccg cttgaaaaga 126001 aacagcttct gtctgagaaa gaataccgtg cttatcttga taaatacggt aataaattcc 126061 aagcatctat gggtgctgaa gcaattcata aacttcttca agatatcgat cttgtaaaag 126121 aagttgatat gttaaaagaa gagctgaaaa cttcacaagg acaacgccgt actcgtgcga 126181 tcaaacgtct tgaagtttta gaagccttcc gtaactcagg aaacaagcct tcttggatga 126241 tccttgatgt gcttcctgtt attcctccgg agcttagacc gatggttcag ctagatggcg 126301 gacgttttgc gacttctgat ttgaatgacc tttatcgtcg tgtcatcaac cgtaacaatc 126361 gtttgaaacg ccttttggac cttggtgcgc ctagcatcat cgttcaaaac gaaaagcgta 126421 tgcttcaaga ggctgtcgat gccctaattg acaacggccg ccgcggacgc cctgtaacag 126481 gtcctggaaa cagaccgtta aaatctcttt ctcacatgct gaaagggaag caaggccgtt 126541 tccgtcaaaa ccttcttggt aaacgtgtcg attactccgg acgttctgta atcgttgttg 126601 gtcctcattt gaaaatgtac caatgcggat taccgaagga aatggcactt gaacttttca 126661 aacctttcgt tatgaaagaa cttgttgaaa aaggtcttgc tcacaacatt aagagtgcga 126721 aacgcaaaat tgagcgcgta cagcctgaag tttgggatgt actagaatca gttattaagg 126781 agcatccggt actgctgaac cgtgccccta cacttcacag attaggtatc caggcgtttg 126841 aaccaacgct tgttgaagga cgcgcaatcc gtcttcaccc gctcgtatgt acagcttaca 126901 acgctgactt tgacggtgac caaatggcgg ttcacgtacc attatctgct gaagcacaag 126961 ctgaagcacg catcttgatg cttgctgctc aaaacatctt gaaccctaaa gatggtaaac 127021 cggttgtaac accgtctcag gatatggtac taggtaacta ttacctgaca cttgagcgtg 127081 ccggtgctgt cggtgaaggt atggtcttca agaatacaga cgaagcgctt cttgcttatc 127141 aaaacggata tgttcacctt catacgagag tagctgttgc agctaactca cttaagaatg 127201 tgacatttac cgaagaacag cgctcaaaat tgttaattac aactgtcggt aagcttgtct 127261 tcaatgaaat tcttccggaa tcattccctt acatgaatga accaacgaag agcaacattg 127321 aagagaaaac acctgaccgt ttcttcttag aaaaaggtgc tgatgttaaa gctgttatcg 127381 cacagcagcc aatcaatgcg ccgtttaaaa aaggcattct gggtaaaatc atcgcggaaa 127441 tctttaaacg attccatatt acggaaacgt ctaaaatgct tgaccgcatg aaaaacctag 127501 gtttcaaata ttcaactaaa gctggtatta cagttggggt ttctgacatc gtcgtactcg 127561 atgataaaca agaaattctt gaggaagcgc aaagcaaagt tgacaacgtt atgaagcaat 127621 tccgccgcgg tcttatcact gaagaagaac gctatgagag agtcatctct atctggagtg 127681 ctgcaaaaga cgttatccaa ggcaaactga tgaaatcact tgatgaactc aacccgatct 127741 acatgatgag tgactctggt gcccgtggta acgcatctaa ctttacgcag cttgccggaa 127801 tgcgcggcct gatggccaac ccggctggac gtatcattga gttgccgatc aaatcaagtt 127861 tccgtgaagg tctgacagta ttggagtact ttatctccac acacggtgcg cgtaaaggtc 127921 ttgccgatac cgctcttaaa actgctgact caggttacct tacacgccgt ctcgttgacg 127981 ttgctcagga tgttatcatc cgtgaaactg attgcggaac tgaccgaggc attcttgcta 128041 agcctcttaa agaaggaact gaaacaattg agcgcttaga agaacgctta atcggacgtt 128101 ttgcaagaaa acaagtgaag caccctgaaa caggtgaagt gcttgtgaat gaaaacgaac 128161 tgatcgatga agataaagca ctggagattg tcgaagccgg cattgaagaa gtgtggatcc 128221 gttctgcctt cacatgtaat acgcctcatg gtgtatgtaa acgatgctat ggccgaaatc 128281 ttgcaactgg ctccgatgtt gaagtcggtg aagctgtcgg aatcattgct gcccaatcaa 128341 tcggtgagcc tggtacacag ttaacaatgc gtacattcca tacaggcggg gttgccggag 128401 acgatatcac acagggtctt ccgcgtatcc aagagctttt cgaagcgcgt aatccgaaag 128461 gtcaggcaac aattacagaa atcgacggta cagtcgttga gatcaatgaa gttcgtgata 128521 agcaacagga aattgtggtt caaggcgcag tggaaacacg ttcttatacg gcaccttaca 128581 actcccgcct gaaagtagcg gaaggagata aaattactcg aggccaagta ctgacagaag 128641 gttcaatcga tccgaaagaa cttcttaaag tgactgacct gacgactgtt caagagtatc 128701 ttctccatga ggttcaaaag gtttaccgta tgcagggtgt tgaaatcggt gataaacacg 128761 tagaagtaat ggttcgccag atgcttcgca aagtacgcgt gattgatgcc ggtgacactg 128821 atgtgcttcc aggtacattg cttgatattc accaatttac tgaagcgaac aaaaaggtat 128881 tgcttgaagg caaccgacca gctacaggcc gtcctgtctt actcggtatt acaaaagcat 128941 ctcttgaaac tgattcattc ttatctgctg cttccttcca ggaaacaaca cgtgtcctta 129001 cagatgcagc gatcaaaggt aagcgtgacg agcttctcgg cttgaaagag aatgttatca 129061 tcggtaagct tgttccagca ggtacaggaa tgatgaaata ccgtaaagta aaaccagtat 129121 caaatgttca gccgactgac gatatggtcc cggttgaata actgatttaa ctctgctgaa 129181 agactgcaaa aacagtcttt cagcagatat atttatgaaa aagtcactct atgagaagaa 129241 cgaatctaaa aaatgtcata ccttgttgac attcgtctcc tagaatgata atataaccaa 129301 ggtgctcgaa ataaacctgt tactttggag gatatgttta tgtcttatga taaagtatca 129361 caggccaaat caattattat tggtacgaag caaacagtga aagctctaaa gcgaggttca 129421 gtaaaggaag tagtcgttgc aaaagacgca gatccgatac tcacgtcaag tgttgtttca 129481 cttgctgaag atcaaggtat ctctgtctca atggttgaat ccatgaaaaa gctcggcaaa 129541 gcctgcggaa ttgaggtagg agcagccgct gttgccatta ttttataacg tacttttgtt 129601 tttgcgtaag attccatctt gtgtaaagac attgtttttt gccttttgat gaaccacctg 129661 ggtatgtggg ttataaaacg taatgaaggg aggaaaaatt catgcctaca attaatcagc 129721 taattcgcaa aggacgcgtg agtaaagtag aaaactcaaa gtctcctgca cttaacaaag 129781 gatacaacag ctttaaaaaa gagcacacta acgtatcttc tccacaaaaa cgcggggtat 129841 gtactcgtgt tggtacaatg acaccgaaaa aaccgaactc agcacttcgt aaatatgctc 129901 gtgttcgttt gactaacgga atcgaggtta ctgcttacat tcctggtatc ggtcacaacc 129961 tgcaagagca cagtgttgta cttatccgcg gcggacgtgt aaaagactta ccaggggtac 130021 gttaccacat cgttcgtggt gcgcttgata ctgctggagt tgaaaaccgt gcacaaggcc 130081 gttctaaata cggtacgaaa aaacctaaag caaaataata tacgaaaata cgcataattg 130141 atgaagggag gatattcaga tgccacgtaa aggtcctgta gcaaaaagag atgttttacc 130201 tgatccgatt tacaactcta agcttgtatc tcgtttaatc aacaaaatga tgatcgatgg 130261 taaaaaaggt aagtctcaaa cgatcctata caagtcattc gatatcatta aagaacgtac 130321 tggcaatgat gcaatggagg ttttcgaaca agcattgaaa aacatcatgc ctgtacttga 130381 agtaaaagca cgccgtgtag gtggtgcgaa ctaccaagtt cctgtagaag ttcgtcctga 130441 acgtcgtacg actcttggac ttcgctggtt agttaactac gctcgtcttc gtggagaaaa 130501 aacgatggaa gagcgtttag ctaacgaaat ccttgacgca gctaacaaca ctggtgctgc 130561 tgttaagaaa cgtgaagaca ctcataagat ggctgaagca aacaaagcat ttgctcacta 130621 tcgctggtag gatttataga ttaacaaaac acaatttcct aataaggaag gagaaattac 130681 ccaatggcaa gagagttctc cttagaaaaa actcgtaata tcggtatcat ggctcacatc 130741 gatgccggta aaacgactac tacagaacgt atcttgttct atactggtcg tatccacaaa 130801 attggtgaaa ctcatgaagg agcttcacaa atggactgga tggagcagga acaagaacgt 130861 ggtatcacaa tcacttccgc tgcgactact gcacagtgga aaggataccg cgtaaacatc 130921 atcgatactc caggacacgt agacttcaca gttgaagttg aacgttctct tcgtgtactt 130981 gatggtgctg ttgctgtact tgacgcgcaa tcaggcgttg agcctcaaac agaaactgtt 131041 tggcgtcagg caacaactta tggagtaccg cgtatcgttt ttgttaacaa aatggacaaa 131101 atcggtgcag acttccttta ctctgtagga actttaagag accgtcttca agcaaacgct 131161 catgcaattc aattgccgat cggtgctgaa gataacttcg aaggtatcat tgaccttgta 131221 gaaaacgttg cgtatttcta cgaagatgac ctcggaactc gttctgatgc aaaagaaatc 131281 cctgaagagt acaaagagca agctgaagag cttcgcaaca gccttattga agctgtatgt 131341 gagcttgatg aagagcttat ggataagtac cttgagggtg aagaaatcac aattgacgag 131401 ttaaaagcag gaattcgtaa aggtacatta aatgttgaat tctaccctgt tcttgttggt 131461 tctgccttca aaaacaaagg tgttcaacta gtacttgatg ctgttcttga ctaccttcct 131521 gcaccaactg acgttgctgc aatcaaaggt acacgtcctg atacaaatga agagattgag 131581 cgtcattctt ctgacgaaga gccattctct gcattagcat ttaaagttat gactgaccct 131641 tacgttggta agttgacgtt cttccgtgtg tactctggaa cacttgattc tggttcatac 131701 gtgaaaaact ctactaaagg caaacgtgag cgtgttggac gtattcttca aatgcacgct 131761 aacagccgtg aagaaatctc tactgtatac gcaggggata tcgcagctgc tgtaggtcta 131821 aaagatacaa ctactggaga tactctatgt gatgagaagg atcttgttat ccttgagtca 131881 atggaattcc cagaaccagt tatcgacgtt gctattgagc ctaaatcaaa agctgaccaa 131941 gataaaatgg gtatcgcttt agcgaaactt gctgaagaag atcctacatt ccgtactcaa 132001 acaaacccag aaactggcca aacgatcatc tctggtatgg gtgaacttca ccttgatatc 132061 attgttgacc gtatgaaacg cgaatttaaa gtagaagcca atgttggtgc tcctcaagtt 132121 gcgtaccgtg aaacattccg taccggtgca aaagttgaag gtaaattcgt acgtcagtct 132181 ggtggacgcg gtcagttcgg acacgtttgg atcgaattcg aaccaaacga agaaggcgct 132241 ggctttgaat ttgaaaatgc gattgtcggt ggggtcgttc ctcgtgaata catcccagct 132301 gttcaagcag gtctggaaga tgcactcgaa aatggtgtac tagcaggctt cccgcttatc 132361 gacattaaag ctaaactttt cgacggttct taccatgatg ttgactcaaa cgaaatggca 132421 tttaaagtcg ctgcttctat ggcattgaaa aatgcagtca gcaaatgtaa cccagttctt 132481 cttgaaccaa tcatgaaagt ggaagtggtt attccagaag aatatatggg agatatcatg 132541 ggtgatatca cttcacgtcg cggacgcgta gaaggtatgg aagcacgcgg taacgctcaa 132601 gttgttcgtg ctatggttcc tcttgctgaa atgttcggtt acgctactgc acttcgttct 132661 aatacgcaag gtcgcggtac gttcactatg cacatggatc actacgaaga agtgccgaag 132721 agcgtcgcag aagaaattat caaaaaaaat aaaggcgaat aattgatttt gccgcttaac 132781 tcaagtataa ctactattgt aagatgagga agtgaaagct ttctttcact tcctatcact 132841 ctatacatta ctaattaaaa gctcttaagg aggattttag aatggctaaa gaaaaattcg 132901 accgttccaa atcacatgcc aatattggta caattggaca cgttgaccat ggtaaaacaa 132961 ctttaactgc tgctatcaca acagtacttc ataagaaatc tggtaaaggt acagctatgg 133021 cgtacgatca aattgatggt gctccagaag aacgcgagcg cggtatcaca atctctactg 133081 cacacgttga gtacgaaact gaaactcgtc actatgcaca cgttgactgc ccaggacacg 133141 ctgactatgt taaaaacatg atcactggtg ctgcgcaaat ggacggagct atccttgtag 133201 tatctgctgc tgatggccca atgccacaaa ctcgtgagca catccttctt tctaaaaacg 133261 ttggtgtacc atacatcgtt gtattcttaa acaaatgcga catggtagac gacgaagagc 133321 ttcttgaact agttgaaatg gaagttcgcg atcttcttag cgaatacgac ttccctggtg 133381 atgatgtacc agttgttaaa ggttctgctc ttaaagctct tgaaggagac gctgagtggg 133441 aagctaaaat cttcgaactt atggatgcgg ttgatgagta catcccaact ccagaacgcg 133501 acactgaaaa accattcatg atgccagttg aggacgtatt ctcaatcact ggtcgtggta 133561 cagttgctac tggccgtgta gaacgcggac aagttaaagt cggtgacgaa gttgaaatca 133621 tcggtcttca agaagagaac aagaaaacaa ctgttacagg tgttgaaatg ttccgtaagc 133681 ttcttgatta cgctgaagct ggtgacaaca ttggtgccct tcttcgcggt gtatctcgtg 133741 aagaaatcca acgtggtcaa gtacttgcta aaccaggtac aatcactcca cacagcaaat 133801 tcaaagctga agtttacgtt ctttctaaag aagagggtgg acgtcatact ccattcttct 133861 ctaactaccg tcctcagttc tacttccgta caactgacgt aactggtatc atccatcttc 133921 cagaaggcgt agaaatggtt atgcctggag ataacactga aatgaacgtt gaacttattt 133981 ctacaatcgc tatcgaagaa ggaactcgtt tctctattcg tgaaggcgga cgtactgttg 134041 gttcaggcgt tgtttctaca atcactgagt aatagtatgg ttttaaacga gacccctgtg 134101 ggtctcgttt tttgtttgct tatctttttc ttgtataata ggatctatca tattcgaggg 134161 gttaatattt atgattcctg aaaagaaatc aatcgcaatc atgaaagaac taagcattgg 134221 aaatacaaag caaatgctga tgattaatgg agttgacgtg aaaaatccat tgctgctttt 134281 tttacatggc gggccgggaa cgccgcaaat cggatatgtt agacattatc aaaaagagct 134341 ggaacagtat tttacagtag ttcattggga tcagagagga tcggggcttt cttattctaa 134401 gcgaatttcg catcactcta tgacaataaa tcacttcatt aaagatacaa tccaagtcac 134461 tcaatggctt ttagctcatt tttcaaaatc aaaactttac ctagccggtc attcttgggg 134521 atcaatactg gcgcttcatg tgctgcagca gcgtcctgat ttattttaca cgtattatgg 134581 aatcagccag gttgttaacc cgcaagatga agaatcaact gcttatcaac atattcgtga 134641 aatttccgaa tcaaaaaaag ccagcatatt atctttcctt acacgtttca ttggtgctcc 134701 gccttggaag caggatatcc agcaccttat ctatcggttt tgtgttgagc taaccagggg 134761 aggattcact caccgtcatc gtcaatctct cgctgtatta tttcaaatgc ttactggcaa 134821 tgagtatgga gtgcggaaca tgcacagctt ccttaatgga ttgcgcttca gtaaaaaaca 134881 tttaactgat gagttgtacc ggtttaatgc ttttacatca gttccttcta ttaaagtacc 134941 gtgtgttttc atttcaggga aacatgactt aattgttcct gcagaaatat cgaaacagta 135001 ttatcaagaa cttgaggcac ctgaaaagcg ctggtttcaa tttgagaatt cagctcacac 135061 cccgcatatt gaggagccat cattattcgc gaacacatta agtcggcatg cacgacacca 135121 tttatgatag atccttgata aataagaaaa acccctgtat aataaaaaaa gtgtgcaaat 135181 catgcatatt ttaaataagt cttgcaacat gcgcctattt tctgtataat ggtgtatgtt 135241 ggtctttgac tgcgatgaag tgagaggttg ctgacacacc cggccgcttt gccatggcaa 135301 ggtgttcagg tttttctcac ggagaactgt ctaacgtgat gtaggcgaaa aggagggaaa 135361 ataatggcaa aacaaaaaat tcgtattcgt ttgaaagcat atgatcatag aatccttgat 135421 caatctgcag agaagattgt tgaaacggca aaacgttctg gtgccagcgt atctggtccg 135481 attccgttgc caactgaaaa atcagtttac acaatccttc gtgcggtgca caaatacaaa 135541 gattctcgtg agcaatttga aatgcgtaca cataaacgtt taatcgacat tgtgaaccca 135601 acaccacaaa ctgttgatgc tcttatgcga ttagacttac catctggtgt cgatatcgaa 135661 attaaacttt aattctaaaa tatagaatga tcttaatagg aggtgtgacg aatgaccaaa 135721 ggaatcttag gaagaaaaat tggtatgacg caagtattcg ctgagaatgg tgatcttatt 135781 ccggtaactg ttatcgaggc tgctccaaac gttgttcttc aaaagaaaac agctgaaaac 135841 gacggttacg aagcaatcca gcttggtttt gacgacaagc gtgaaaagct ttctaacaaa 135901 cctgaaaaag ggcacgttgc aaaagcggaa actgctccta agcgcttcgt taaagaatta 135961 cgcggagtgg aaatggatgc gtatgaagtt ggtcaggaag tcaaggttga aattttctct 136021 gctggagaaa tcgtagatgt aacaggagta tctaaaggta aaggtttcca aggtgcgatc 136081 aagcgccacg gacaatctcg cggacctatg tctcacggtt cacgctacca ccgtcgtcct 136141 ggttcaatgg gacctgtaga tcctaaccgt gtattcaaag gtaaattatt acctggacgt 136201 atgggcggag agcaaatcac tgttcaaaac cttgaaatcg taaaagttga tgcagaacgc 136261 aatcttcttt tgatcaaagg taacgtacct ggtgcgaaga aatctttaat cactgttaaa 136321 agtgctgtta aatctaaata attctcttag gaaaggagga aattgattat gccaaaagta 136381 gcattataca accaaaacgg ttctactgct ggtgacatcg aattaaacgc ttctgtattt 136441 ggtatcgaac caaatgagag tgttgtattc gacgctattc ttatgcaaag agcttcctta 136501 cgtcaaggaa ctcacaaagt aaaaaatcgt tctgaagtac gcggcggagg tcgtaaacca 136561 tggcgtcaaa aaggtactgg acgtgcccgt caaggttcaa tccgttcacc gcaatggcgc 136621 ggaggtggtg tcgtattcgg cccaacacca cgcagctatt cttataaatt acctaaaaaa 136681 gttcgccgct tggcaatcaa atcagtattg tcttctaaag tgatcgacaa caacatcatc 136741 gttcttgaag atcttactct tgatacggct aaaacaaaag aaatggcagc tatccttaaa 136801 ggattatctg ttgagaaaaa agctttaatc gtaactgcgg atgcaaacga agcagtagca 136861 ttatctgctc gtaacattcc tggagttact gttgttgaag ctaacggaat caacgtttta 136921 gacgttgtca accacgagaa gcttctgatt acaaaagcag cggttgaaaa agtagaggag 136981 gtgcttgcat aatgaaagat cctcgtgatg ttctaaagcg ccccgtcatt actgaacgtt 137041 ctgccgattt aatgactgaa aaaaaatata cttttgaagt tgatgtaaga gctaacaaaa 137101 cagaagtgaa agacgcggtt gaaagcatct ttggagtgaa agttgacaaa gtcaacatca 137161 tgaactacaa aggcaaatca aaacgtgttg gacgctacac tggtatgact agccgtcgca 137221 gaaaagcgat cgtaaaactt actgcagaca gcaaagaaat cgaaattttt gaagcttaat 137281 tatctgtaaa aagaaggagg gaaattcaaa atggcgatta aaaagtataa accgacctct 137341 aatggacgtc gtggcatgac aacttcagat tttgctgaaa tcacgactga caagccggaa 137401 aaatccttgc ttgctcccct tcacaaaaaa ggcggacgta acaaccaagg taaattgact 137461 gtacgtcacc aaggtggcgg acataaacgc caataccgtg ttatcgactt caaacgcgat 137521 aaagatggta tacctggacg cgttgctaca gttgaatacg atccaaaccg ttcagctaac 137581 atcgctctaa tcaactatgc agacggagaa aaacgttaca ttcttgctcc taaaggaatt 137641 caagtaggta ctgaaatcat gtcaggtcct gaagctgaca ttaaagtagg taatgcactt 137701 ccacttatca acatccctgt tggtacagtt gtgcataaca ttgaattaaa acctggtaaa 137761 ggcggacagc ttgtacgttc agctggtaca tctgctcagg ttcttggtaa agaaggtaaa 137821 tacgttcttg tacgtcttaa ctctggtgaa gttcgcatga tcctttctgc ttgccgtgct 137881 tctatcggtc aagtaggtaa cgaacagcac gaacttatca acattggtaa agctggacgt 137941 tctcgctgga aaggcatccg tcctacagtt cgtggttctg taatgaaccc taacgatcac 138001 ccacacggtg gtggtgaagg acgtgcgcca atcggacgta aatcaccaat gtctccatgg 138061 ggcaaaccaa ctcttggatt caagactcgt aagaaaaaga acaaatccga taaatttatc 138121 gtacgtcgtc gtaaaaataa ataacggggt tgtctacggt tcttttcgga ccgtagtgca 138181 atcacgaagg gaggttccaa aatggctcgc agcttaaaaa aaggaccatt tgtcgatgga 138241 cacttgatga ctaaaatcga gaaattaaat gaaacagaca agaaacaagt cgtaaaaact 138301 tggtctcgtc gttctactat tttcccacag tttattggtc acacaatcgc agtctatgac 138361 ggacgtaaac acgtgcctgt attcatctct gaagatatgg tagggcacaa gttgggtgaa 138421 ttcgctccaa ctcgtacgta caaaggtcat gctagtgatg acaaaaaaac aagacgctaa 138481 gagaggaggc ttttaaatgc aagctaaagc tgttgcaaga acagtccgta ttgctcctcg 138541 taaagcacgt ctagtaatgg acctgattcg aggcaagcaa gtaggtgagg cagtatcaat 138601 cttgaacctt acaccaagag ctgcttctcc aattatcgag aaagtattaa aatccgctat 138661 tgcaaatgct gagcataact atgaaatgga cgctaacaac ctggttattt ctcaagcatt 138721 cgttgacgaa ggccctacgt taaaaagatt ccgcccacgt gctatgggac gtgcgagcca 138781 aatcaacaaa cgtacgagcc acattacaat cgttgtatca gaaaagaagg agggataagt 138841 agtgggtcaa aaggtaaatc cagtcggtct tcgtatcgga gtcattcgtg attgggaatc 138901 taagtggtac gctggtaaag attacgctga cttcctgcac gaagatttaa aaattcgtga 138961 atacattagc aaacgccttt ctgacgcttc tgtttctaaa gtagaaattg agcgtgcagc 139021 aaaccgcgtt aacattacga tccacacagc taagcctggt atggttatcg gtaaaggcgg 139081 ttctgaagtc gaagcacttc gcaaagccct taacagcctt actggcaagc gtgtacacat 139141 taacattctt gaaatcaaaa gagcagatct tgatgcacag ctagttgctg acaacatcgc 139201 tcgtcaatta gaaaaccgtg tttctttccg ccgtgcgcag aaacaacaaa tccaacgtac 139261 tatgcgtgct ggagcacaag gtgtgaaaac aatggtttct ggtcgtcttg gcggtgcaga 139321 tatcgctcgt tctgaatact acagtgaagg aactgttcca ttgcacacat tacgtgcgga 139381 cattgactat gcaacatctg aagctgatac tacttacggt aagcttggtg taaaagtctg 139441 gatctatcgt ggagaggttc ttcctactaa gaagaaaaat gaggaaggag gaaaataata 139501 tgttattacc aaaacgcgtt aaatatcgca gagagcatcg cggaaaaatg cgtggccgtg 139561 cgaaaggcgg tactgaagta catttcggag aattcggtat ccaagctcta gaagcttctt 139621 ggattactaa ccgtcaaatc gaagctgcac gtattgcgat gactcgttac atgaaacgtg 139681 gcggtaaagt ttggatcaaa attttccctt ctaaacctta cactgctaaa ccacttgagg 139741 tacgtatggg atccggtaaa ggggctccag aaggttgggt agctgttgta aaaccgggca 139801 aagttttatt tgaaatttct ggtgtgtctg aagaggttgc tcgtgaagcg cttcgccttg 139861 catctcacaa attgccaatt aaaacgaagt tcgtaaaacg tgaagaaatt ggtggtgaat 139921 caaatgaaag ctaatgaaat tcgtgacctt accactgctg aaattgaaca aaaagtaaag 139981 tctcttaaag aagaactttt caatcttcgc tttcaattag cgacaggaca acttgaaaat 140041 actgctcgca ttcgtgaagt gcgcaaagct atcgcgcgca tgaaaactgt gattcgtgaa 140101 agagaaattg ctgctaataa ataatcactg aggggaggtc gtgagcatga gcgaacgtaa 140161 ccaacgcaaa gtttaccaag gccgtgttgt ttctgacaaa atggataaaa ccattactgt 140221 tgttgttgag acatacaaaa aacatacact ttacggtaaa cgcgtaaaat actcaaaaaa 140281 attcaaagca catgatgaaa ataatcaagc taaaatcggt gacatcgtta agatcatgga 140341 aactcgtcca ttgtctgcaa ctaagcgttt ccgtctagtt gaagttgtcg aagaagctgt 140401 tattatctaa taaagttcgg aattcttttt ccgaagggag gtaacaaata atgattcaac 140461 aagagactcg tttaaaagta gctgacaact ctggcgcacg tgaagtactt actattaaag 140521 ttcttggtgg ttctggacgt aaaacagcta acattggtga tgtaattgtt tgcacggtta 140581 aacaagcaac accaggaggc gttgtcaaaa aaggtgaagt cgtaaaagct gttatcgttc 140641 gcactaaaag cggagcgcgc agaagtgacg gttcatacat cagcttcgat gagaatgcat 140701 gtgttatcat ccgtgacgac aagagcccac gcggaactcg tatcttcgga ccagttgctc 140761 gtgaattgcg tgaaaacaac tttatgaaaa ttgtttctct agctccagaa gttatctaat 140821 tgaaataaat gccttactca aggaggtgcg atcaggatgc atgtaaaaaa aggcgataaa 140881 gttatggtta tctctggtaa agataaaggc aaacaaggaa caatccttgc tgctttccct 140941 aaaaaggacc gcgttttagt tgaaggtgtt aacatggtaa agaaacactc taaaccaact 141001 caagctaacc ctcaaggcgg tatttctaat caagaggcgc caattcatgt atcaaacgtt 141061 atgccgctcg atcctaaaac aggtgaagtg actcgcgtag gatacaaagt ggaagatggc 141121 aaaaaagttc gtgtagcaaa aaaatctggg caagttctag ataaatagta ttaaaaggaa 141181 gggaggtcta tctcatgaac cgccttaaag aaaagtacaa taaagaaatt gcacctgctt 141241 taatgactaa gttcaactat gattcagtca tgcaagtgcc taaaatcgaa aaaatcgtaa 141301 tcaacatggg tgttggtgac gctgttcaaa acgccaaagc aatcgacagt gctgttgagg 141361 aattaacgtt tatcgcaggt caaaaacctg tcgttactcg tgcgaagaaa tcaattgctg 141421 gattccgtct tcgtgaggga atgcctatcg gtgcgaaagt aactcttcgc ggagagcgca 141481 tgtatgattt ccttgataaa cttatttctg tatctttacc gcgtgtacgt gacttccgcg 141541 gggtttctaa aaaatctttc gacggtcgcg gtaactacac acttggtatc aaagaacagt 141601 taatcttccc tgaaattgac tacgataaag taacaaaggt tcgcggaatg gacatcgtta 141661 tcgtaacaac tgctaatact gacgaagaag ctcgtgagct attaactcaa gtaggtatgc 141721 cgttccagaa ataatcaatg aaagggaggc gaaatcgtgg ctaaaaagtc tatgattgcg 141781 aaacaacaac gtacaccaaa gtttaaagta caagagtaca cacgctgtga acgctgcgga 141841 cgtccgcatt cagtcattcg taaatttaaa ctttgccgta tttgtttccg tgagcttgca 141901 tataaaggac aaattcctgg cgtgaaaaaa gccagctggt aatccccaag aaagggaagg 141961 aggtaattat ataatggtta tgacagatcc aattgcagat atgctaactc gtattcgcaa 142021 tgcaaacatg gtacgtcatg agaagcttga aattcctgct tctaaattga aaagagaaat 142081 tgctgaaatt ttaaagcgtg aaggtttcat tcgtgacgtt gagttcgtag aagacagcaa 142141 acaaggtatt atccgcgttt tcttgaaata cggacaaaac aacgagcgcg ttatcactgg 142201 tcttaaaaga atcagcaagc ctggtttgcg tgtttatgct aaatctaatg aagtaccccg 142261 cgtacttaac ggtcttggaa tcgcgattat ttctacatca caaggtgttt taacggacaa 142321 agaagcccgt gcaaaacaag ctggtggaga agttctagca tacgtttggt aagaagttta 142381 acatgaatgg aggtgtttgg tatgtctcgt gtaggtaaga agctacttga gattccttct 142441 gatgttacag taacgttaaa tgataacaac actgtagctg tgaaaggacc aaaaggagaa 142501 ttaactcgta cgtttcaccc tgatatggag attaaagtag aggacaatgt gcttacagtc 142561 gctcgtcctt ctgatcaaaa agagcaccgt gccctgcatg gtacgactcg cagtctgctt 142621 ggcaacatgg ttgaaggtgt atctaaagga tttgaaagag gtttggaatt agtcggtgtc 142681 ggttaccgtg cttctaaatc cggaaataaa cttgttttaa acgttggata ctctcatcct 142741 gttgagatcg ttcctgaaga aggcatcgaa atcgaagttc cttctcaaac aaaagtagtt 142801 gtaaaaggta cagacaaaga acgcgtagga gctattgctg ctaacatccg cgctgtacgt 142861 tctccagagc cttacaaagg taaaggaatc cgctacgaag gtgaagttgt tcgccgtaaa 142921 gaaggtaaat ctgctaagta agatcgctta aagtgaagaa aggagtgacc tagatgatta 142981 cgaaaactag caaaaatgct gctcgtctta aaagacacgc tcgtgttcgc gctaaacttt 143041 ccggtactgc tgaaagaccg cgcctgaacg ttttccgttc taacaagcac atttacgctc 143101 aaatcatcga tgatgtaaat ggtgtaacac ttgctagtgc atctactctc gataaagact 143161 tgaacgttga aagcactgga gatacttctg ctgctactaa agttggagaa ttagttgcaa 143221 aacgcgctgc tgaaaaaggc atttctgacg tagtatttga ccgtggcgga tacttatacc 143281 atggacgtgt aaaagctttg gctgatgccg ctcgtgaagc tggacttaaa ttttaataaa 143341 agaaggaggg acacatgatt atgcgtcgta ttgacccaag caaattagag ttagaagaac 143401 gcttagttac ggttaaccgc gtagcgaaag ttgttaaagg tggtcgtcgt ttccgcttcg 143461 cagctctagt cgttgtcggt gacaaaaacg gacacgtagg attcggtact ggtaaagcac 143521 aagaagtacc agaagcgatt cgcaaagctg ttgaagatgc gaaaaagaat ttgattgaag 143581 taccaatggt tggaactaca attccacacg aaatcatcgg acgtttcggt gcaggtaaca 143641 tcttgttaaa acctgcttct gaaggtactg gagttatcgc tggaggccct gtacgtgcgg 143701 tacttgagct agctggtgta gctgatatcc tttctaagtc tttaggttct aacacaccga 143761 tcaacatgat tcgtgcaaca cttcaaggtt taagtgaact taaacgtgct gaagacgttg 143821 cgaagcttcg tggaaaatct gtagaagaac tgttaggata aggagggaac attaatggct 143881 aaattagaaa ttaccctcaa acgaagtgta atcggtcgcc cggaagacca acgcgttact 143941 gtaagaacac ttggtttaaa gaaaacaaac caaactgttg ttcatgaaga caacgctgcg 144001 atccgtggta tgattaataa agtatctcat ttagtttctg ttaaagaaca ataaaaatat 144061 ttgatcggat aaggaggtgt cctaatgaaa cttcatgaat taaaaccttc agaaggttca 144121 cgcaaaacgc gtaatcgcgt aggtcgtggt attggttctg gcaacggtaa aacagctggt 144181 aaaggtcaca aaggtcaaaa cgctcgttct ggcggcggtg tacgccctgg attcgagggg 144241 ggacaaatgc ctttattcca acgtcttcct aaacgtggtt tcactaacat caaccgcaag 144301 gaatacgctg tagtcaacct agacaaattg aacggttttg cagaaggaac ggaagtcact 144361 cctgaacttc ttctagagac tggtgttatt agcaaactta atgcaggagt aaagattctt 144421 ggcaacggta aattagagaa aaaattaact gtaaaagcca ataaattctc tgcttctgcg 144481 aaagaagctg ttgaagctgc tggcggtaca gctgaggtga tctaacttgt ttaaaacaat 144541 ctccaacttt atgcgtgtga gtgatatcag gaataaaatc atattcactt tactcatgct 144601 tatcgtcttt cgcataggtg cgtttattcc tgtgccttac gttaacgctg aagcgttaca 144661 ggcacagtct caaatgggtg tttttgatct ccttaataca tttggcggcg gtgcgcttta 144721 ccaattttcc attttcgcaa tgggaattac tccttatatc acggcttcga tcatcattca 144781 gctgcttcag atggatgtgg taccgaagtt taccgagtgg tctaagcaag gtgaagttgg 144841 ccgccgtaaa ttagctcagt tcacaaggta ctttacgatt gtgcttggtt tcatccaagc 144901 gttaggtatg tcatatggat tcaacaatct ggcaaacggt atgctgatcg aaaaatccgg 144961 tgtatcgaca tatcttatca ttgctttagt gctcactggc ggaactgcct ttttaatgtg 145021 gcttggggaa caaattactt ctcatggagt aggcaacgga atatcgatca ttatcttcgc 145081 ggggattgtg tctagtattc caaaaacaat tgggcaaata tatgagactc aatttgtcgg 145141 cagcaacgat cagttgttta ttcatattgt gaaagtcgca cttcttgtga ttgcgatttt 145201 agcagttatt gttggagtta ttttcattca gcaagccgta cggaaaattg cgattcaata 145261 tgctaaaggc acaggtcgtt cacctgctgg cggaggtcag tctacacacc ttccattgaa 145321 agtgaatcct gcaggggtta ttccggtaat ctttgcggtt gcgtttttga taacgccgcg 145381 gacgatcgcg tcattctttg gaacaaacga tgtgacaaag tggattcaaa acaactttga 145441 taatacgcat ccggtgggta tggcgatata tgttgcgttg attattgcct ttacgtactt 145501 ttatgctttt gtacaggtaa accctgaaca aatggctgat aaccttaaaa aacagggtgg 145561 ctatatcccg ggggttcgtc cagggaaaat gactcaagat agaattacga gcattttgta 145621 tcgacttacg tttgtgggtt ctatattctt agccgtgatt tccattcttc ctatcttttt 145681 cattcaattc gctggattgc ctcaaagtgc acaaattggc ggaacatctt tgttaattgt 145741 tgtcggggta gccttggaga caatgaaaca actagaaagc cagttggtga aacgaaacta 145801 ccgtggattt atgaaaaact agaggaaatg gatttatcca ttccctctta ataaagagag 145861 gacgggggaa atccgaatga acttagtctt aatggggctt cctggtgccg gtaaaggcac 145921 acagggcgaa cgaattgttg aggattatgg gattcctcat atctcaacag gagatatgtt 145981 ccgtgctgct atgaaagaag aaacaccact cggactcgaa gcaaaatctt atattgataa 146041 gggagagctc gtacctgacg aagtcacaat cggaattgta aaagagagac ttggcaaaga 146101 tgattgtgaa agaggttttc ttctggacgg atttccgcga acagtcgctc aagccgaagc 146161 tcttgaagaa attcttgagg aatacggcaa gccgattgat tatgtcatta acattgaagt 146221 cgacaaagat gttctgatgg aacgtctgac tggacgcaga atttgcagtg tttgcggcac 146281 aacctatcat ttagtcttta atccgccgaa aacgccgggt atttgtgata aagacggagg 146341 cgaactctat caacgggcag atgataatga ggaaacagtc tctaaacggc ttgaggtaaa 146401 catgaagcaa actcagcctt tactcgattt ctattcagag aaaggttatc ttgcaaacgt 146461 gaatggccag caggacattc aagacgttta tgcagatgtg aaggatcttc ttggaggatt 146521 aaaaaaatga ttatctgtaa aaccccacgt gaacttggta tcatgcggga agcagggcga 146581 atcgtggctt taactcatga agagttaaaa aagcacatta aaccaggaat ctcgacaaaa 146641 gaattggatc aaattgccga acgttttatt aagaagcagg gtgcaatccc atcttttaag 146701 gggtataatg ggtttcgcgg gagcatttgc gtatcagtta atgaagaact cgttcacggc 146761 atacctggca gcagggtgct gaaggacggt gacatcatca gtattgatat cggtgctaaa 146821 ttaaatggtt atcatggtga ctctgcatgg acatatccgg taggaaacat cagcgatgat 146881 gacaaaaaac ttctggaagt gacagaggag tctttatata aaggcttgca ggaagcaaaa 146941 ccaggtgaac gtttgtcgaa tatttcccac gcaatacaaa cgtatgtcga aaatgagcag 147001 ttttcagttg ttagggagta tgtcggacat ggtgttggtc aagacttgca tgaggacccg 147061 caaattcctc attacggtcc gcccaacaaa ggaccacggc ttaaacctgg catggttctc 147121 gctattgaac ctatggtgaa cgctggcagc cgctacgtga aaacattggc tgataactgg 147181 acggttgtaa cggtagatgg gaaaaagtgt gctcattttg aacatacgat tgcgattacg 147241 gaaacgggtt ttgatatact gacgagagtc tagatgatga aaataattcc gaagacagat 147301 gtttttcaag cttgataggg cagaaagctt gggtgaacat tggcaagacc gaattcatct 147361 tgcttcttgt cgttggaatt ttaaccatca tcaatgtact aacagcagac ggagaaaagc 147421 gtacatttca ttctcctaag aaaaagaata tcaatcattt aaccctttat gattgcgtat 147481 ctccggaagt tcagaacagt ataaacgaaa cagggcgtgt gacaaacttc ttttgaaatt 147541 tgtcagaaag caagttactg atttgaagaa gggagaacac ttgaatggcg aaagacgatg 147601 taattgaagt ggaaggtact atagtcgaaa cactgccaaa cgcgatgttc aaagttgaac 147661 ttgaaaatgg ccacactgtt ttggctcatg tatctggtaa aatccgcatg cacttcattc 147721 gcattttacc tggagacaaa gttacggtag aattatctcc atatgactta actcgtggca 147781 ggattacgta ccgttacaaa taaagcactc cggaaactga aggaggttgg aaacacatga 147841 aagtgagacc atcagttaaa ccaatctgcg aaaaatgtaa agttattcgc agaaaaggaa 147901 aagtaatggt gatctgtgaa aatccaaagc ataaacaaaa acaaggataa tttataagga 147961 ggtgcccaga gaatggctcg tattgctggt gtagatatcc cacgtgacaa acgtgttgtt 148021 atttctttaa catacatctt cggaattggc cgcacaacgg ctcagcaagt tttaaaagaa 148081 gctggagttt cagaagatac tcgtgtgcgc gatcttactg aagaagaact tggtaaaatc 148141 cgtgatatta ttgacaaact gaaagtagaa ggtgaccttc gccgtgaagt ttctcttaat 148201 atcaaacgtc tgatcgaaat cggaagctac cgcggaatcc gtcatcgcag aggattacct 148261 gttcgcggac aaaactctaa aaacaacgcg cgtactcgta aaggtccgcg tcgtactgta 148321 gctaacaaga aaaaataagt aagggaggtt cttaaacaat ggctgctgct cgtaaatcta 148381 acacgcgtaa acgtcgcgtg aaaaagaata ttgagtctgg aattgctcat attcgttcaa 148441 ctttcaataa cacgatcgtt acgatcactg acactcatgg taatgctatt tcttggtcta 148501 gtgccggagc tttaggattc agaggttctc gtaaatctac tccttttgct gcgcaaatgg 148561 ctgcagaaac agctgctaaa ggttcaatcg aacatggtct taaaactcta gaggttactg 148621 ttaaaggacc tggttcaggc cgtgaagctg caatccgtgc acttcaagct gctggactag 148681 aagtcactgc tatcagagac gtaactcctg ttcctcataa cggatgccgt ccaccaaaac 148741 gtcgccgcgt gtaatttgtt tgtatagatt ttgtgtccct gtcaataatg ggttatgata 148801 cagttattta tgaaacgaat gcaccgactc gttgcctgag cacatacggg actaaacaat 148861 ggggaatttc ggatggaatc tcatatgatt ctattcgagg tttcgacgtt ttgaaggagg 148921 gttttaagta atgatcgaga ttgaaaaacc aaaaatcgaa acggttgaaa tcagcgacga 148981 tgccaaattt ggtaagtttg tcgtagagcc acttgagcgt ggatatggta caactctggg 149041 taactcctta cgtcgtatcc tcttatcctc actccctggt gccgctgtaa catcaatcca 149101 gatagatggt gtactgcacg aattctcgac aattgaaggc gttgtggaag atgttacaac 149161 gattatctta cacattaaaa agcttgcatt gaaaatctac tctgatgaag agaagacgct 149221 agaaattgat gtacagggtg aaggaactgt aacggcagct gatattacac acgatagtga 149281 tgtagagatc ttaaatcctg atcttcatat cgcgactctt ggtgagaatg cgagtttccg 149341 agttcgcctt actgctcaaa gaggacgtgg gtatacgcct gctgacgcaa acaagagaga 149401 cgatcagcca atcggcgtga ttccgatcga ttctatctat acgccagttt ctcgtgtatc 149461 ttatcaggta gagaacactc gtgtaggcca agttgcaaac tatgataaac ttacacttga 149521 tgtttggact gatggaagca ctggaccgaa agaagcaatt gcgcttggtt caaagatttt 149581 aactgaacac cttaatatat tcgttggttt aactgacgaa gctcaacatg ctgaaatcat 149641 ggttgaaaaa gaagaagatc aaaaagagaa agttcttgaa atgacaattg aagaattgga 149701 tctttctgtt cgttcttaca actgcttaaa gcgtgcgggt attaacacgg ttcaagagct 149761 tgcgaacaag acggaagaag atatgatgaa agttcgaaat ctaggacgca aatcacttga 149821 agaagtgaaa gcgaaactag aagaacttgg actcggactt cgcaaagacg attgactagt 149881 ttcccttgtg aactaggatt ttcgtgtgtt tattattcag aaacagcatt ccaataaagg 149941 aggggacatc acatgtcata cagaaaacta ggacgtacga gtgcacagcg taaagctatg 150001 cttcgtgatc ttacaactga tttgatcatc aacgaaagaa tcgaaacaac tgaaacacgt 150061 gcgaaagaac ttcgctctgt agttgaaaaa atgatcacgc ttggcaaacg cggtgatctt 150121 cacgctcgcc gtcaagctgc tgcatacatc cgcaacgagg ttgcaaacga agaaaataat 150181 caagatgcac ttcaaaaatt attctctgac attgcaactc gttacgagga gcgccaaggt 150241 ggatacacac gtattatgaa gcttggtcct cgccgtggtg acggagcacc aatggcaatt 150301 atcgaattgg tttaatcaca tatttttgtg tatctaaaga agggcgggac agtttctaac 150361 tggatctatg cccttttttt agatactgca acttttaata gagagaaaag cagagcatta 150421 gctgagagga ggccggtttt ccatgaatca aaatcagttg atatcggtag aggatatcgt 150481 atttcgatat cggaaggacg cagaaagacg agcactagac ggcgtctccc tgcaggtgta 150541 tgagggtgaa tggcttgcaa tcgtaggtca taacggttca gggaaatcaa cactggcccg 150601 ggcattgaat ggtttaattc ttcctgaatc aggcgacatt gaggttgccg ggattcaatt 150661 gacagaggaa tctgtttggg aagtgcgtaa gaagataggt atggtctttc aaaatccgga 150721 taaccaattt gtcggaacga ctgttcgcga tgatgtggct tttggtttag aaaacaatgg 150781 tgtaccgcgg gaagaaatga ttgagagagt agactgggca gtaaaacagg tgaatatgca 150841 agattttctc gatcaagagc cgcaccatct ctccggaggc caaaagcaga gagttgcgat 150901 tgcgggggtt attgccgcac gtcctgatat tattatctta gatgaagcaa catccatgct 150961 tgatccgatc gggcgagaag aagtgcttga aacggtaaga catttaaaag agcagggcat 151021 ggcgactgtc atatccatta cacatgacct gaatgaggca gcaaaagcag acaggatcat 151081 tgtcatgaat ggcggtaaaa aatatgctga agggccgcct gaagagattt ttaaattgaa 151141 taaagaactt gttcgaattg ggcttgattt acccttctca ttccagctta gccagctttt 151201 aagagaaaat ggactggctt tggaagaaaa ccatttgact caggaagggc tggtgaaaga 151261 gctgtggaca ttacaatcaa agatgtagag catcgctatc agatgaagac cccgtttgag 151321 cgcctagcac tgtatgatat caatgcatcg attaaagaag gaagctacgt agccgttatc 151381 gggcatacag gctctggcaa gtccactctt ctacagcacc taaatggtct cctgaagccg 151441 acgaagggac agatatcact aggcagcact gtcattcagg cagggaaaaa gaataaagat 151501 ctgaaaaaac ttcgtaaaaa agtcggaatc gttttccaat ttcctgagca tcaattattc 151561 gaagaaacag ttcttaaaga tatttcattc ggaccgatga actttggtgt taaaaaagaa 151621 gatgctgaac aaaaagcgag agagatgctg cagcttgtag gtttatcaga agagcttttg 151681 gacaggtcac cctttgaatt aagcggggga caaatgcgca gagttgcaat tgccggcgta 151741 cttgcaatgg accctgaagt gcttgttctg gatgaaccga ctgcaggatt ggacccaaga 151801 gggcgaaaag agattatgga catgttttat gagcttcatc aacgtgggaa cttgacgacg 151861 atccttgtga cacacagcat ggaggatgca gctgcatacg ctgatgaaat gattgttatg 151921 cataaaggaa cgatacaagc atcaggcagt ccgcgtgatc tgtttttaaa gggtgaagag 151981 atggccggct gggggctgga tcttcctgaa acaataaaat tccaaagaca ccttgaagct 152041 gcactgggtg tgagatttaa tgagcctatg ctcacaatcg aagatgccgc tgccgaaatc 152101 cgtgctcttt ttcagggaga gaagacttta tgatggacag catgattatc ggcaagtatg 152161 taccggggac ttcacttgtg caccggcttg accccagaac aaaactgatc acgatctttt 152221 tatttgtctg cattgtattc ttagccaata atgttcagac atatgcgttg cttggtttat 152281 ttacaattgg cgtcgtttct ttaacaagag ttcctttctc ttttttaatg aaagggctga 152341 agccaatcat ctggattgtc ctttttacgt tccttcttca cattcttatg acacatgaag 152401 gaccgattat ctttcaaata ggttttttca aagtctatga gggcggtctg gttcagggga 152461 tattcatttc tcttagattc gtctatttga ttttaatcac aaccttatta acgcttacga 152521 ctacaccgat tgagattacc gatggaatgg agcagctgct gaacccattg aaaaaattaa 152581 agcttcctgt tcatgagctg gctcttatga tgtcaatttc tttacggttt attccgacac 152641 tgatggagga gacagataag atcatgaagg ctcagatggc gcgaggcgtt gattttacaa 152701 gcgggcctgt caaagaaaga gtgaaggcta ttgtcccgct tcttgtcccg ctcttcgtca 152761 gcgcatttaa acgcgccgaa gagcttgcgg tggcaatgga agcaagaggc tatcaaggcg 152821 gagaaggacg tacgaaatat agaaagcttg tatggacagg aaaagacact tctgtcattg 152881 tcagcttaat tgtattagct gctttgttat ttttcttaag ggcttagagg tgctgtatga 152941 gactgaaatg cacgatttct tatgacggac atttgtttaa cggttatcag gttcagccgg 153001 gcaaaagaac ggttcaggat gaactggaga aggctttggc tgtcctgcat aagtcaaaag 153061 acagaattcc ggtcgtttcg tctggaagaa cagacagcgg ggttcacgca gccggacagg 153121 tgattcattt tgacactccg ctgtctatcc cggctgagag atggccatat gccttaaatg 153181 cactgcttcc ggacgatatc gcagtcaaac aggcagaaat tgcggatgat gggttccatg 153241 cacgatttag cgcagtcaaa aaagaatatc gctactttgt atacacggag aaacacccgg 153301 acgtatttaa acggcattac gcttaccatt tttcatatcg ccttaatgtg caggacatga 153361 gagaagcggc aaagcatctt atagggacac atgattttac gagcttttgc gcggctaaaa 153421 cagaagtgca ggacaaggta agaacgatat acgaacttga ttggactgag acggctgacg 153481 gcctgcaaat gcggatcaca ggcagcggtt tcttatataa tatggtcaga attattgcgg 153541 gtactttgct tgatgcaggt attggaaaaa tttctcccga tgaggtgaaa tccatgctgg 153601 aagcgaagga tcgcgaagcg gcagggcgca cagcgccggg gcacgggcta tatttatgga 153661 acgtttacta tgacaactaa accaggtgta taatattttc ttgacagagt ctgcataaag 153721 ttataagata tcatatggta tgtatttcaa ccccacgata agccccggaa cttattgtgt 153781 tgtgaaatag aacgtaatcg aagtttattg aaaatgacag atcatttagg agggaaattc 153841 aatgcgtaca acacctatgg ctaacgcaag tactattgaa cgcaagtggt tagttgttga 153901 tgctgctggc aagactttag gtcgtctttc ttcagaagtt gcagctatcc ttcgcggaaa 153961 acacaaacca acttacacac cacacgttga tactggagat catgtgatca tcatcaacgc 154021 tgaaaaaatc gagttaactg gtaaaaagtt aactgacaaa atctactacc gtcacactca 154081 acatccaggc ggattaaaat caagaactgc tcttgaaatg cgtacaaact accctgagaa 154141 aatgcttgag cttgctatca aaggcatgct tccaaaaggt tctctaggtc gtcaaatgtt 154201 caaaaaattg aacgtatacc gtggttctga gcatccacac gaagcacaaa aacctgaagt 154261 ttacgaactt cgcggttaat taaaaaggag gttaccaatt tggcacaggt tcaatattac 154321 ggtactggcc gtcgtaaaag ctctgtagcg cgtgtgcgtt tagttccagg agaaggccgt 154381 atcgtcgtta ataatcgtga aatcagcgaa catatcccat ctgcagcttt aatcgaagat 154441 atcaaacaac cattaacttt gactgaaaca gctggcactt atgatgtttt agtaaacgta 154501 catggaggcg gcctatctgg tcaagctgga gcaatccgtc acggtatcgc tcgtgctttg 154561 cttgaagcag atccagaata ccgtacaact cttaaacgtg caggtcttct gactcgtgac 154621 gctcgtatga aagaacgtaa aaaatacggt cttaaaggcg ctcgtcgtgc acctcagttc 154681 tcaaaacgtt aattttacgt tttcaaaaag ctctcgacct tgggttggga gcttttttct 154741 ttcaataaaa cgtggcagtc ccgcataaaa ataacaactg aatggacgct tgacggggtt 154801 aagcaaattg tttgtttata aacggtctct ttgtaataat catggtagat ttcattctta 154861 ttcaattgga agttcggtca atgtttatta tcgttatgtg atcagcccag ctccatctaa 154921 ccactgtatc tcatccgtta aagttcactg ctgattctta acccggagaa acaatagctc 154981 tcattgctaa tggctttatg taacgaagta aaagtaaatc tgatgatata aatcacatat 155041 ctcctttgtg atttttttgc gtttttatga acttttttct aaatatgcaa agggaaagcg 155101 atatcaatct agaaatattt gttatactct atacattaaa gtaaggagaa gattcatgaa 155161 tgcgttagta gctcataata gcaaagcctg ggataaaaaa gtagaaacag gcaatgaatg 155221 gactgttgct gttgaacagc aggttatcga acaagcaaaa aaaggcaatt gggatataag 155281 ggtaacacca atgaaagatg taccgaagga ttggtttccg cctatcaaag gtctgaaagt 155341 actctgttta gcatcaggcg gcggccagca gggtccagtt ttggcagccg caggcgcgga 155401 tgtcactgta ttagataact cagaaaaaca gctgaatcag gatagaatga ttgctgagcg 155461 agatggtctg acgatacaca ctgtcaaagg aagcatggac gatttaagtg tatttaatga 155521 tgaatcattt gatgtcattg tacatcctgt tgccaatgtt tttgttgaga atgtcctccc 155581 ggtatggaag gaagcgtacc gtgtgttgaa aaggaacggc attctaatct cgggttttgt 155641 caatcctgtt gtatttctgt ttgatacaga attagaacag caaggtgttt taaaagtaaa 155701 acactctatt ccatacgctg acccagaaga tcttccgaaa cataaagtga aaaaactgat 155761 cgaaaataat gaggctctgg aattcggcca ttccttagaa gaccaaatca aaggccaaat 155821 tgatgccggt tttatcgtta ctggttttta tgaagataaa ggcggttttg tattagacca 155881 atatatccat acatattctg caacaagaag cgtgaaagta tgaaaagcag cgacctgtta 155941 gaggggctgc ttttttcata accaattaca gaacatttgt tcctcaccct gcagaaagct 156001 gattttttat caatgttaca ccttcatttg ggcgaatttc caaccgaatt cgggcattgt 156061 ttcatcatcc aaacctcaaa ataatcggta aaaggagagt gaatttatat ggcagaagta 156121 ctgtctttta tggatgtgaa acgccaaaag gattttgaat tagaaaagaa cttgctcaaa 156181 gaactctctc tgagacaaat tatccagtct gttaaggatt gtttggaacc attatttcca 156241 tttttacatg atgaacgaga tattattacc gaaggctgta ttgattttgc gattgaagct 156301 tatttgttag gcgggcgttt tgggatattc ggctattacg gagaatcaat gcagagtatc 156361 agtgcccgct ctgcaagaga agaagaagag ctgcgtatgg agttttttga ttatctctat 156421 aattggatac acgagcaata cgcaacattt gataaaaaca ctgtttatga agcggcacgc 156481 aagttcatta aagattggtg gacagcaggg tttgttcaaa gagaaaaaca gtgtaagctt 156541 cgcatgcggt aatcatattt cccgaccctg tcccatagtt atgtaataac ggacaagcgg 156601 gaggggaagg gatgaggaaa aagcttaaat ggctcagttt tttgctaggc ttcatcatat 156661 tactatttct gttcaagtat cagttcagca ataacgactc ttggaagccg tggagcctgc 156721 ccttgagcgg taaaatcatt tatctagatc caggtcatgg cgggcctgac ggcggagcag 156781 tcggcggaaa gctgttagag aaggatgtta ccctggaagt ggcctttaga gtcagggatt 156841 atcttcaaga acaaggagcg cttgttatca tgaccagaga aagtgatact gatctcgctc 156901 cagaaggaac aaaaggctat agccgacgaa aagctgagga tctaagacaa cgagtcaaat 156961 taataaacca ttcagaggcg gagctctata tcagcattca tcttaatgcg attccgtcac 157021 aaaaatggag cggagcccaa agcttttatt acgggaaata tgcggaaaat gagaaagtcg 157081 caaaatacat tcaggatgag ctgagaagaa atctggaaaa cacaacccgg aaagcaaagc 157141 ggattcatgg tatctactta atgcaaaacg tcaccaaacc gggggcgctt atagaagtcg 157201 gatttttatc caatccaagt gaagcaacgt tgctcggtaa accgaaatat caagacaagg 157261 tggcatcttc catatataaa ggcattttgc gatatttcac agaaaaagga gaccctccgg 157321 agtaatggag ggttttcttg tggttctaag cataagacac ccgccattta tgtatgatat 157381 aataataatt gtaaacgaat acacaaaagg gtgaggttcg atgataagag aagatgaagt 157441 aagaaaacta gtcggagaaa tgcgcgaacc ttttcttcaa agacctctgg gagaattgga 157501 tgccgttaag gaaattaaaa taaagcctga aaaacggcat atcagtgtaa aagtcgctct 157561 tgcaaaaaca ggaactgcag aacaaatgca gattcagcaa gagatcgtaa acgtattaaa 157621 aggggcagga gctgagacag tcggccttcg atttgaagag ctgcctgaag aaacggttgc 157681 taaattccgg gcgccgtcag ctgagaaaaa aacattatta aatatggata acccgccagt 157741 ctttcttgct gtagcaagtg gaaaaggcgg cgtaggcaag tcaactgtgt cagtaaacct 157801 agctatttct ctggctcgtc tagggaaaaa ggttggttta attgatgcgg atatttatgg 157861 gttcagtgtg ccggacatga tgggtatcac tgtgcgtcca acaattgaag gagagaaact 157921 tcttcctgtt gaacgctttg gagtaaaggt catgtcaatg ggctttttcg tagaagaaaa 157981 tgccccggtc gtatggagag ggccgatgct cggcaaaatg ctgaataatt ttttccatga 158041 agtagagtgg ggagaagtag actatatcgt tcttgatctt ccgcctggta caggggacgt 158101 tgctctcgat gtacatacaa tgcttccgag ctgcaaagaa attatcgtat ctacgccaca 158161 tccgacagct gcttttgtcg cggccagagc gggctctatg gcgattaaaa ccgatcatga 158221 ggtcgtgggt gtcatagaga acatggctta ttatgaaagt gcaaagacag gggaaagaga 158281 atatgtgttt ggaaaaggcg gaggagataa actggctgag gaactaaacg tgcctttgct 158341 cggcagaatc ccattgaaac agcccgattg ggataaggac caatttgctc cgtctgttta 158401 tgacgaaaat catccaatcg gagaaatata tcaggacatc gcaaaaaaaa tagatgcaaa 158461 aatgtcagtg caggtataaa aggtgaaccg ggattccaga tcccggcttt ccctttattc 158521 actttctttt gctgtgtctt ttgctgcttt tttcagctca tcttcgaact gctttttgta 158581 aagcggacta gaaagtgttt cgttaataac ctcttctaaa taactgcgga attcttggct 158641 ttttgccagc tggctgtact ttttatccat gccgggatcc tgcataacgc tcatcagcat 158701 cttctggtaa tctggatcct tcatcagctt tttaatcact ttttcatgct ctgtctgaag 158761 agttttggca aagccctcag caaaatcagt gtcttcaaag atgtttttcc aaaattcttc 158821 acctttttta gatgtgagtg ttttttctat tgttccttta attgcatctt ggtcaatcac 158881 cagcgcttca ttcatggcat catcatttaa taattcctta atagctttct ttccatcatc 158941 agtttttaat atatcaacaa ccattttttt ggtctgatca tagtccatat ccgctgcttg 159001 gtcttttgga gcgcaagctg ttacagataa taacaaaaaa cagctcatca atagcgtttt 159061 ggcttttgac atgcttaagc tcctttcaca tacttgtctt acctttaata tgattcatct 159121 gtttggaatt atacataaca aaatatcgct gttcgcgatt tttgagggga tgaataaaga 159181 aatgaaaagc cgtggtttag ttcgtttttt cttttctatt ttagctgtcg gggcgcttat 159241 cacgagtatt gtgggttttg ctttaaagtg gggagaatat agagggctgt ttctaacatt 159301 tgaagcggga cagattttct ctgttttatt ttggtttatc ggtgtaggca tgattttcag 159361 tgtgatcagc caaatgggtt ttttcgtgtt tttaacagtt catcggtttg cgcttgagat 159421 attaaggtcc tcctctttgt ggaatttgct gcagttgttt ttcatcctgt ttgttgcttt 159481 tgatttaatg tacgtgcgtt ttttattttt tggagagagc ggagaatcgc tggctggcta 159541 tgcgtggtta ccggtgtttt tattgatctt tggagtgatt acagcttata taaagcaaaa 159601 gcagtcctct aagaaaacat ttgtgtcatc gttatttttg atggttgtga ttaccgcatt 159661 agaatggttc cctgcattaa gagtaaatga tgaggactgg ctttatttaa tgctttttcc 159721 gttaatggca tgtaatgcct tccaattgct gatgctgccg aagtttgcag caaagtaatt 159781 actttacctc tgcggatttg gcatcagaat ttgcgatgag atcacccacg gttacatttt 159841 ttaatccttt ttctttcagc tgatggatga tatcaggcaa tgcttcttct gtttgttttg 159901 cagaatcgga ggcatgtaaa agaataatgt ctccaccgga aacttgcttg gtcacattgt 159961 cgatgatttt ttcaactccg ggatttgtcc agtcttgaga gttcacactg taatgaacga 160021 ctgtataatt gtattgcttt gcgaccttta gaacattctt attgaattgg ccggtagggg 160081 gtcttaatag ctgtatgtct ttgaccccta acttttcaaa ggctgtttgc gcacggttca 160141 tgtccttttt tatttcgctg ctctctaaat tggcatagtt tttataagcg tagcccatgc 160201 tcccgatttg atggccgtcc tttacgatac gggccactgt gtcgggatgg cgttctgccc 160261 aagaagcgga caggaaaaac gttgcgtttt taatcccgtt tgctttcaga gtattaagta 160321 tcggttctgc tctctcatca ccccagctga tatcgaaagt aagtgaaata tctttagagt 160381 ctgtttctcc tttataaatg gctttaggtc cggtgtcagt tgaaaacacg ggaagcggga 160441 cagctctttg gatataaaaa aagctggcag ctgcaaatgc ggcgataagt ataataatta 160501 attgttttac ccgtttaatg tgccacacat agaagtgatt cactgatgat gcctccttat 160561 cttgtccatc attcttgttt tacatcttat gagcatggac aattgaatat aaccgataaa 160621 atgtctcttc acatacagcc taaattgggt gttgaccttt tgataatatc cgtgatatat 160681 tattattcgt cgctgataaa cagctgacat caactaaaag cttcattaaa tactttgaaa 160741 aaagttgttg acttaaaaga agctaaatgt tatagtaata aagctgcttc gttaagcggc 160801 agtaatgatc tttgaaaact aaacaagaca aaacgtacct gttaattcat ttttataaat 160861 cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat cctggctcag 160921 gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg gagcttgctc 160981 cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta agactgggat 161041 aactccggga aaccggggct aataccggat ggttgtttga accgcatggt tcaaacataa 161101 aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag ttggtgaggt 161161 aatggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc cacactggga 161221 ctgagacacg gcccagactc tacgggaggc agcagtaggg aatcttccgc aatggacgaa 161281 agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa gctctgttgt 161341 tagggaagaa caagtaccgt tcgaataggg cggtaccttg acggtaccta accagaaagc 161401 cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagctt tgtccggaat 161461 tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc ccccggctca 161521 accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag tggaattcca 161581 cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg cgactctctg 161641 gtctgtaact gacgctgagg agcgaaaacg tggggagcga acaggattag ataccctggt 161701 agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct tagtgctgca 161761 gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac tcaaaggaat 161821 tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc 161881 ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt cgggggcaga 161941 gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc 162001 aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta aggtgactgc 162061 cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg 162121 gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg ttaagccaat 162181 cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg aagctggaat 162241 cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt gtacacaccg 162301 cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt ttaggagcca 162361 gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc gtatcggaag 162421 gtgcggctgg atcacctcct ttctaaggat attatacgga atataagacc ttgggtctta 162481 taaacagaac gttccctgtc ttgtttagtt ttgaaggatc attccttcga aacgtgttct 162541 ttgaaaacta gataacagta gacatcacat tcaagtaata caagatatca catagtgatt 162601 ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta ggagccgatg 162661 aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg atccggagat 162721 ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga attcatagga 162781 tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag agaaagcaaa 162841 tgcgattccc tgagtagcgg cgagcgaaac gggattagcc caaaccaaga ggcttgcctc 162901 tggggttgta ggacactctg tacggagtta caaaggaacg aggtagatga agaggtctgg 162961 aaaggcccgc cataggaggt aacagccctg tagtcaaaac ttcgttctct cctgagtgga 163021 tcctgagtac ggcggaacac gtgaaattcc gtcggaatcc gggaggacca tctcccaagg 163081 ctaaatactc cctagtgacc gatagtgaac cagtaccgtg agggaaaggt gaaaagcacc 163141 ccggaagggg agtgaaagag atcctgaaac cgtgtgccta caagtagtca gagcccgtta 163201 acgggtgatg gcgtgccttt tgtagaatga accggcgagt tacgatctcg tgcaaggtta 163261 agcagaagat gcggagccgc agcgaaagcg agtctgaata gggcgcatga gtacgtggtc 163321 gtagacccga aaccaggtga tctacccatg tccagggtga agttcaggta acactgaatg 163381 gaggcccgaa cccacgcacg ttgaaaagtg cggggatgag gtgtgggtag gggtgaaatg 163441 ccaatcgagc ctggagatag ctggttctct ccgaaatagc tttagggcta gcctcaaggt 163501 aagagtcttg gaggtagagc actgattgga ctaggggccc ctaccgggtt accgaattca 163561 gtcaaactcc gaatgccaat gacttatcct tgggagtcag actgcgagtg ataagatccg 163621 tagtcgaaag ggaaacagcc cagaccgcca gctaaggtcc caaagtatac gttaagtgga 163681 aaaggatgtg gagttgctta gacaaccagg atgttggctt agaagcagcc accatttaaa 163741 gagtgcgtaa tagctcactg gtcgagtgac tctgcgccga aaatgtaccg gggctaaacg 163801 tatcaccgaa gctgcggact gttcttcgaa cagtggtagg agagcgttct aagggctgtg 163861 aagccagacc ggaaggactg gtggagcgct tagaagtgag aatgccggta tgagtagcga 163921 aagaggggtg agaatcccct ccaccgaatg cctaaggttt cctgaggaag gctcgtccgc 163981 tcagggttag tcgggaccta agccgaggcc gaaaggcgta ggcgatggac aacaggttga 164041 tattcctgta ccacctcctc accatttgag caatgggggg acgcaggagg atagggtaag 164101 cgcggtattg gatatccgcg tccaagcagt taggctggga aataggcaaa tccgtttccc 164161 ataaggctga gctgtgatgg cgagcgaaat atagtagcga agttcctgat tccacactgc 164221 caagaaaagc ctctagcgag gtgagaggtg cccgtaccgc aaaccgacac aggtaggcga 164281 ggagagaatc ctaaggtgat cgagagaact ctcgttaagg aactcggcaa aatgaccccg 164341 taacttcggg agaaggggtg ctctgttagg gtgcaagccc gagagagccg cagtgaatag 164401 gcccaggcga ctgtttagca aaaacacagg tctctgcgaa gccgtaaggc gaagtatagg 164461 ggctgacgcc tgcccggtgc tggaaggtta agaggagcgc ttagcgtaag cgaaggtgcg 164521 aattgaagcc ccagtaaacg gcggccgtaa ctataacggt cctaaggtag cgaaattcct 164581 tgtcgggtaa gttccgaccc gcacgaaagg cgcaacgatc tgggcactgt ctcaacgaga 164641 gactcggtga aattatagta cctgtgaaga tgcaggttac ccgcgacagg acggaaagac 164701 cccgtggagc tttactgcag cctgatattg aatgttggta cagcttgtac aggataggta 164761 ggagccttgg aaaccggagc gccagcttcg gtggaggcat cggtgggata ctaccctggc 164821 tgtattgacc ttctaacccg ccgcccttat cgggcgggga gacagtttca ggtgggcagt 164881 ttgactgggg cggtcgcctc ctaaaggtaa cggaggcgcc caaaggttcc ctcagaatgg 164941 ttggaaatca ttcgcagagt gtaaaggcac aagggagctt gactgcgaga cctacaagtc 165001 gagcagggac gaaagtcggg cttagtgatc cggtggttcc gcatggaagg gccatcgctc 165061 aacggataaa agctaccccg gggataacag gcttatctcc cccaagagtc cacatcgacg 165121 gggaggtttg gcacctcgat gtcggctcat cgcatcctgg ggctgtagtc ggtcccaagg 165181 gttgggctgt tcgcccatta aagcggtacg cgagctgggt tcagaacgtc gtgagacagt 165241 tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga gctgtcctta gtacgagagg 165301 accgggatgg acgcaccgct ggtgtaccag ttgttctgcc aagggcatcg ctgggtagct 165361 atgtgcggac gggataagtg ctgaaagcat ctaagcatga agcccccctc aagatgagat 165421 ttcccattcc gcaaggaagt aagatccctg aaagatgatc aggttgatag gtctgaggtg 165481 gaagtgtggc gacacatgga gctgacagat actaatcgat cgaggactta accatatttt 165541 tgaatgatgt cacatctgtt atctagtttt gagagaacac tctcaatttg tttggtggcg 165601 atagcgaaga ggtcacaccc gttcccatac cgaacacgga agttaagctc ttcagcgccg 165661 atggtagtcg ggggtttccc cctgtgagag taggacgccg ccaagcagat ttattaattc 165721 taccatgttt gtttatgaag ctttatatct cattccgcag tagctcagtg gtagagctat 165781 cggctgttaa ccgatcggtc gtaggttcga atcctacctg cggagcattg cttccatagc 165841 tcagcaggta gagcacttcc atggtaagga agaggtcagc ggttcgagcc cgcttggaag 165901 cttaaatgta ttattaccaa ggtttctcat aaggagaaag ctttttttat tgcgatatgc 165961 ggaagtagtt cagtggtaga acaccacctt gccaaggtgg gggtcgcggg ttcgaatccc 166021 gtcttccgct ccatttacct aacgggatat tgtaaattga attgcgcccg tagctcaatt 166081 ggatagagcg tttgactacg gatcaaaagg ttaggggttc gactcctctc gggcgcgcca 166141 tatcttttaa tagaatagat aggaaatcgg gaagtagctc agcttggtag agcacatggt 166201 ttgggaccat ggggtcgcag gttcgaatcc tgtcttcccg accatttttt atggggcctt 166261 agctcagctg ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg 166321 ctccaccaaa agtttttaaa aaaggttatt gactttgaag aagtgacatt gtatactaat 166381 aaagttgctt taacaaagcg gacaaacaaa atgatctttg aaaactaaac aagacaaaac 166441 gtacctgtta attcagtttt taaaaatcgc acagcgatgt gcgtagtcag tcaaactact 166501 ttatcggaga gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa 166561 gtcgagcgga cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg 166621 tgggtaacct gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt 166681 tgtttgaacc gcatggttca aacctaaaag gtggcttcgg ctaccactta cagatggacc 166741 cgcggcgcat tagctagttg gtgaggtaac ggctcaccaa ggcaacgatg cgtagccgac 166801 ctgagagggt gatccggcca cactgggact gagacacggc ccagactcta cgggaggcag 166861 cagtagggaa tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga 166921 aggttttcgg atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg 166981 gtaccttgac ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa 167041 tacgtaggtg gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct 167101 taagtctgat gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt 167161 gagtgcagaa gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag 167221 gaacaccagt ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg 167281 gggagcgaac aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt 167341 tagggggttt ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta 167401 cggtcgcaag actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt 167461 ggtttaattc gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta 167521 gagataggac gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg 167581 tgtcgtgaga tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc 167641 attcagttgg gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg 167701 tcaaatcatc atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag 167761 ggcagcgaaa ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt 167821 ctgcaactcg actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg 167881 aatacgttcc cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga 167941 agtcggtgag gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga 168001 agtcgtaaca aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat 168061 tatacggaat ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt 168121 gaaggatcat tccttcgaaa cgtgttcttt gaaaactaga taacagtaga catcacattc 168181 aagtaataca agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg 168241 gtggatgcct tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg 168301 agctgtaagc aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg 168361 agtggtatcc atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat 168421 ctaagtaccc ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg 168481 gattagccca aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac 168541 aaaggaacga ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt 168601 agtcaaaact tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg 168661 tcggaatccg ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc 168721 agtaccgtga gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc 168781 gtgtgcctac aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa 168841 ccggcgagtt acgatctcgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga 168901 gtctgaatag ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt 168961 ccagggtgaa gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc 169021 ggggatgagg tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc 169081 cgaaatagct ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac 169141 taggggcccc taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt 169201 gggagtcaga ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag 169261 ctaaggtccc aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga 169321 tgttggctta gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact 169381 ctggcccgaa aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac 169441 agtggtagga gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt 169501 agaagtgaga atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc 169561 ctaaggtttc ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg 169621 aaaggcgtag gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc 169681 aatgggggga cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt 169741 aggctgggaa ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata 169801 tagtagcgaa gttcctgatt ccacactgcc aagaaaagct ctagcgaggt gagaggtgcc 169861 cgtaccgcaa accgacacag gtaggcgagg agagaatcct aaggtgatcg agagaactct 169921 cgttaaggaa ctcggcaaaa tgaccccgta acttcgggag aaggggtgcc ctgttagggt 169981 gcaacccgag agaaccgcag tgaataggcc ccaggcgact gtttagcaaa acacaggtct 170041 ctgcgaagcc gtaaggcgaa gtatagggct gacgcctgcc cggtgctgga aggttaagag 170101 gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg ccgtaactat 170161 aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac gaaaggcgca 170221 acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg tgaagatgca 170281 ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg atattgaatg 170341 ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca cttcggtgga 170401 ggcatcggtg ggatactacc ctggctgtat tgaccttcta acccgccgcc cttatcgggc 170461 ggggagacag tgtcaggtgg gcagtttgac tggggcggtc gcctcctaaa aggtaacgga 170521 ggcgcccaaa ggttccctca gaatggttgg aaatcattcg cagagtgtaa aggcacaagg 170581 gagcttgact gcgagaccta caagtcgagc agggacgaaa gtcgggctta gtgatccggt 170641 ggttccgcat ggaagggcca tcgctcaacg gataaaagct accccgggga taacaggctt 170701 atctccccca agagtccaca tcgacgggga ggtttggcac ctcgatgtcg gctcatcgca 170761 tcctggggct gtagtcggtc ccaagggttg ggctgttcgc ccattaaagc ggtacgcgag 170821 ctgggttcag aacgtcgtga gacagttcgg tccctatccg tcgcgggcgc aggaaatttg 170881 agaggagctg tccttagtac gagaggaccg ggatggacgc accgctggtg taccagttgt 170941 tctgccaagg gcatcgctgg gtagctatgt gcggacggga taagtgctga aagcatctaa 171001 gcatgaagcc cccctcaaga tgagatttcc cattccgcaa ggaagtaaga tccctgaaag 171061 atgatcaggt tgataggtct gaggtggaag tgtggcgaca catggagctg acagatacta 171121 atcgatcgag gacttaacca tatttttgaa tgatgtcaca cctgttatct agttttgaga 171181 gaacactctc aatttgtttg gtggcgatag cgaagaggtc acacccgttc ccataccgaa 171241 cacggaagtt aagctcttca gcgccgatgg tagtcggggg tttccccctg tgagagtagg 171301 acgccgccaa gcaattgcac attagtgtaa ttttttaaaa aagttattga ctttgaagaa 171361 gtgacattgt atactaataa agttgcttta acaaagcgga caaacaaaat gatctttgaa 171421 aactaaacaa gacaaaacgt acctgttaat tcagttttta aaaatcgcac agcgatgtgc 171481 gtagtcagtc aaactacttt atcggagagt ttgatcctgg ctcaggacga acgctggcgg 171541 cgtgcctaat acatgcaagt cgagcggaca gatgggagct tgctccctga tgttagcggc 171601 ggacgggtga gtaacacgtg ggtaacctgc ctgtaagact gggataactc cgggaaaccg 171661 gggctaatac cggatggtta gtttgaaccg catggttcaa acataaaagg tggcttcggc 171721 taccacttac agatggaccc gcggcgcatt agctagttgg tgaggtaacg gctcaccaag 171781 gcaacgatgc gtagccgacc tgagagggtg atcggccaca ctgggactga gacacggccc 171841 agactcctac gggaggcagc agtagggaat cttccgcaat ggacgaaagt ctgacggagc 171901 aacgccgcgt gagtgatgaa ggttttcgga tcgtaaagct ctgttgttag ggaagaacaa 171961 gtaccgttcg aatagggcgg taccttgacg gtacctaacc agaaagccac ggctaactac 172021 gtgccagcag ccgcggtaat acgtaggtgg caagcgttgt ccggaattat tgggcgtaaa 172081 gggctcgcag gcggtttctt aagtctgatg tgaaagcccc cggctcaacc ggggagggtc 172141 attggaaact ggggaacttg agtgcagaag aggagagtgg aattccacgt gtagcggtga 172201 aatgcgtaga gatgtggagg aacaccagtg gcgaaggcga ctctctggtc tgtaactgac 172261 gctgaggagc gaaagcgtgg ggagcgaaca ggattagata ccctggtagt ccacgccgta 172321 aacgatgagt gctaagtgtt agggggtttc cgccccttag tgctgcagct aacgcattaa 172381 gcactccgcc tggggagtac ggtcgcaaga ctgaaactca aaggaattga cgggggcccg 172441 cacaagcggt ggagcatgtg gtttaattcg aagcaacgcg aagaacctta ccaggtcttg 172501 acatcctctg acaatcctag agataggact gtcttcgggg gcagagtgac aggtggtgca 172561 tggttgtcgt cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct 172621 tgatcttagt tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga 172681 ggaaggtggg gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta 172741 caatggacag aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc 172801 tcagttcgga tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg 172861 atcagcatgc cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga 172921 gagtttgtaa cacccgaagt cggtgaggta accttttagg agccagccgc cgaagtggga 172981 cagatgattg gggtgaagtc gtaacaaggt agccgtatcg gaaggtgcgg ctggatcacc 173041 tcctttctaa ggatattata cggaatataa gaccttgggt cttataaaca gaacgttccc 173101 tgtcttgttt agttttgaag gatcattcct tcgaaacgtg ttctttgaaa actagataac 173161 agtagacatc acattcaagt aatacaagat atcacatagt gattcttttt aacggttaag 173221 ttagaaaggg cgcacggtgg atgccttggc actaggagcc gatgaaggac gggacgaaca 173281 ccgatatgct tcggggagct gtaagcaagc tttgatccgg agatttccga atggggaaac 173341 ccaccactcg taatggagtg gtatccatat ctgaattcat aggatatgag aaggcagacc 173401 cggggaactg aaacatctaa gtacccggag gaagagaaag caaatgcgat tccctgagta 173461 gcggcgagcg aaacgggatt agcccaaacc aagaggcttg cctcttgggg ttgtaggaca 173521 ctctgtacgg agttacaaag gaacgaggta gatgaagagg tctggaaagg cccgccatag 173581 gaggtaacag ccctgtagtc aaaacttcgt tctctcctga gtggatcctg agtacggcgg 173641 aacacgtgaa attccgtcgg aatccgggag gaccatctcc caaggctaaa tactccctag 173701 tgaccgatag tgaaccagta ccgtgaggga aaggtgaaaa gcaccccgga aggggagtga 173761 aagagatcct gaaaccgtgt gcctacaagt agtcagagcc cgttaacggg tgatggcgtg 173821 ccttttgtag aatgaaccgg cgagttacga tctcgtgcaa ggttaagcag aagatgcgga 173881 gccgcagcga aagcgagtct gaatagggcg catgagtacg tggtcgtaga cccgaaacca 173941 ggtgatctac ccatgtccag ggtgaagttc aggtaacact gaatggaggc ccgaacccac 174001 gcacgttgaa aagtgcgggg atgaggtgtg ggtaggggtg aaatgccaat cgaacctgga 174061 gatagctggt tctctccgaa atagctttag ggctagcctc aaggtaagag tcttggaggt 174121 agagcactga ttggactagg ggcccctacc gggttaccga attcagtcaa actccgaatg 174181 ccaatgactt atccttggga gtcagactgc gagtgataag atccgtagtc gaaagggaaa 174241 cagcccagac cgccagctaa ggtcccaaag tatacgttaa gtggaaaagg atgtggagtt 174301 gcttagacaa ccaggatgtt ggcttagaag cagccaccat ttaaagagtg cgtaatagct 174361 cactggtcga gtgactctgc gccgaaaatg taccggggct aaacgtatca ccgaagctgc 174421 ggactgttct tcgaacagtg gtaggagagc gttctaaggg ctgtgaagcc agaccggaag 174481 gactggtgga gcgcttagaa gtgagaatgc cggtatgagt agcgaaagag gggtgagaat 174541 cccctccacc gaatgcctaa ggtttcctga ggaaggctcg tccgctcagg gttagtcggg 174601 acctaagccg aggccgaaag gcgtaggcga tggacaacag gttgatattc ctgtaccacc 174661 tcctcaccat ttgagcaatg gggggacgca ggaggatagg gtaagcgcgg tattggatat 174721 ccgcgtccaa gcagttaggc tgggaaatag ggaaatccgt ttcccataag gctgagctgt 174781 gatggcgagc gaaatatagt agcgaagttc ctgattccac actgccaaga aaagcctcta 174841 gcgaggtgag aggtgcccgt accgcaaacc gacacaggta ggcgaggaga gaatcctaag 174901 gtgatcgaga gaactctcgt taaggaactc ggcaaaatga ccccgtaact tcgggagaag 174961 gggtgctctg ttagggtgca agcccgagag agccgcagtg aataggccca ggcgactgtt 175021 tagcaaaaac acaggtctct gcgaagccgt aaggcgaagt ataggggctg acgcctgccc 175081 ggtgctggaa ggttaagagg agcgcttagc gtaagcgaag gtgcgaattg aagccccagt 175141 aaacggcggc cgtaactata acggtcctaa ggtagcgaaa ttccttgtcg ggtaagttcc 175201 gacccgcacg aaaggcgcaa cgatctgggc actgtctcaa cgagagactc ggtgaaatta 175261 tagtacctgt gaagatgcag gttacccgcg acaggacgga aagaccccgt ggagctttac 175321 tgcagcctga tattgaatgt tggtacagct tgtacaggat aggtaggagc cttggaaacc 175381 ggagcgccag cttcggtgga ggcatcggtg ggatactacc ctggctgtat tgaccttcta 175441 acccgccgcc cttatcgggc ggggagacag tgtcaggtgg gcagtttgac tggggcggtc 175501 gcctcctaaa aggtaacgga ggcgcccaaa ggttccctca gaatggttgg aaatcattcg 175561 cagagtgtaa aggcacaagg gagcttgact gcgagaccta caagtcgagc agggacgaaa 175621 gtcgggctta gtgatccggt ggttccgcat ggaagggcca tcgctcaacg gataaaagct 175681 accccgggga taacaggctt atctccccca agagtccaca tcgacgggga ggtttggcac 175741 ctcgatgtcg gctcatcgca tcctggggct gtagtcggtc ccaagggttg ggctgttcgc 175801 ccattaaagc ggtacgcgag ctgggttcag aacgtcgtga gacagttcgg tccctatccg 175861 tcgcgggcgc aggaaatttg agaggagctg tccttagtac gagaggaccg ggatggacgc 175921 accgctggtg taccagttgt tctgccaagg gcatcgctgg gtagctatgt gcggacggga 175981 taagtgctga aagcatctaa gcatgaagcc cccctcaaga tgagatttcc cattccgcaa 176041 ggaagtaaga tccctgaaag atgatcaggt tgataggtct gaggtggaag tgtggcgaca 176101 catggagctg acagatacta atcgatcgag gacttaacca tatttttgaa tgatgtcaca 176161 cctgttatct agttttgaga gaacactctc aatttgtttg gtggcgatag cgaagaggtc 176221 acacccgttc ccataccgaa cacggaagtt aagctcttca gcgccgatgg tagtcggggg 176281 tttccccctg tgagagtagg acgccgccaa gcaagcttaa acccagctca ttgagctggg 176341 ttttttgttt tatatctgtg ccgatttgct ttcgtcagta tccattttat caagcttctg 176401 ctttttaaag ttttctaata cttttgaatt ccaatacaat ccctagcatg atcaacatga 176461 gagtcataaa taatcaaaat gcagtttgta cgggagactc atccagactc catccgactg 176521 cgattggcag gatagagccg ccaatccatt ggcagcgaac agcatgcttg tcgtttgttc 176581 tgtttttcca tgataaaatt gattggtgac aataaaataa tggcgaacat gccggccata 176641 aataagtcct aagaaaaaac taagaataat ccctgcaaaa gctgttttat tgattgccaa 176701 aatacagagt taaatgaggc cgctcatatt tatcagcctg agataatgat gataggttat 176761 tttttcggaa accagctcgg gttgccaaat gagagaaaag atattactgt cattaaaacg 176821 attcttggtt tcatccggat atgataaaat gtctcagact atatttgagc catttttttc 176881 ttcagcaatc atcttgcgta attgataaaa atttattatg atactctttg tatgacaact 176941 ccttgcctca atacaatata ctcaacgttt ccccgttttc tccggtcgtt tttcttttca 177001 ttttctcccg taaaataaaa aaagctccca atacaataga tatggtgcgg atttattttt 177061 tactaaaaag gagtcgttat atttgaataa tagttttaca ttaaaacagc aatggttcgg 177121 gaatatccga aaagacattc ttgctggcat tttagttgcg ttagcgttaa tacctgaagc 177181 gattggcttt tctattatag ccggtgtgga tccgatggtc ggtctttatg cgtcattttg 177241 catagccatt attatttcta tttttggtgg cagacctggc atgatttcag ctgcgacagg 177301 ctcaatggca gtcgttatgg tgtcgctggt tgctgatcat gggcttcagt atttatttgc 177361 ggctacgatt ttgacaggca ttattcaggt gattttaggt atcagtaaaa ttgcaagatt 177421 aatgaaattc atcccgcgtt ctgtgatgat cgggtttgtg aatgcgctgg cgatccttat 177481 cttctctgcg cagcttcccc agtttgaagg tgcttcttgg agcatgtatg cgatgcttgc 177541 cgggtcgttg gttattattt atgtgctgcc aaggtttacg actgctgttc cgtctccgct 177601 tgtggcgatt attgtgatga caattattgc ggtcactttc catgtggatg tgcggacggt 177661 tggtgatatg ggcaatattt ctagttcatt gcctcatttc ttaatccctg atgttccgtt 177721 tacctttgaa acactgcaaa ttatttttcc ttattcaatt gctttagcgt ttgtcgggtt 177781 gcttgaatct ttgctgacag cacagattat tgatgaaatg acggatacgg atagtgataa 177841 aaataaagag agccgcggac agggaattgc gaatatcgtg actggattct ttggcggaat 177901 ggcaggctgc gctatgatcg gacaatctgt cattaataca aaagcgggcg gtcgcggacg 177961 tttgtcagca tttgttgccg gtgcttttct gatgttttta attgcggtgt taagtcatgt 178021 cgtggtgaaa atcccaatgg cggcgttagt agctgtaatg gttatggtgt ctgtcggcac 178081 ttttgattgg tcttctttaa aaggtctcaa aaaagcgccg ctcacggact cgattgtcat 178141 ggttgtgact gtggttacgg ttgttgtgac ggatgactta tctaagggtg tatttgtcgg 178201 tgttctttta agtgccgtgt tctttgtagc aaaaatctcg aagctgaaaa tcgtttctca 178261 tgcagaggat caaaagctta gaacgtatca agtgaagggg caaatctttt ttgcgtcagt 178321 gactgatctt acgaatgcgt ttatatatca agaggatatt gagcgggttg tgattgactt 178381 aactgaagct cacgtatggg acgattctgg tgcggccgca cttgataaga ttgttgcgaa 178441 gtttaaggaa caaggcattg aagctgagtt aaaaggtttg aataaagcga gtaaatctct 178501 aatgaaacag atggcataaa atagagaagc ccagatgaat gagatctggg cttttttata 178561 taacatacac ttaagcagca ttgatataat agagagaaga gaaattttaa ataggggact 178621 tgcatatgat gcttcagaag ctgaaccgtg tattggggag agtgatgccg ctgttaacgc 178681 cgactagtgt ggtgctgggc gtgctgctgt ctcagttttt aaatgggtat gaatgggctg 178741 tgccttggat ctttgctttt attacgtttg caggcagttt gagcgcgaac tttcaatctt 178801 tgagacatgc attgtctcat cctctcccta tgattcttgc actattcgtt cttcatattt 178861 tcatgccgct ttttgcttgg ggcagcggcc atcttatatt taaaggtgat cctttgacga 178921 ttaccggttt aacattggct gttgtgattc ctacggggat tacaagcttg atttgggcag 178981 cgatgtacaa agggaatgtc ggtttgacac tttcgattat tttagttgat actgtgctgt 179041 caccgctaat cgtaccgctg agtctttcat tgctggccgg cgctcaggtt cacatggatg 179101 tgtggggaat gatgaaaggt ctgattgtaa tggtcgtgat tccttctttt ttgggcatgc 179161 tgtttaatca gatgtcatct ccagaaagaa ctgcgtttgt gagcagtgcg ctgtcgcctt 179221 tttcaaagct ttgcttgatg gcagtgattg cgattaacag ttcagcgatt gctccttatt 179281 tcaaatccat tgatttgaga tttgcaggaa tagctgtaac ggtattcttt atcgcgttaa 179341 caggttatgc cgctgcttgg ctgatcggaa aaatgatgaa aaggcggcaa gaggaaatag 179401 tctctcttat atttacggga ggcatgagga atattagtgc cggcgcagtt cttgccgtta 179461 cgttcttccc gtctcaggtt gccgttcctg ttgtgatcgg catgctgttt cagcagatat 179521 tggctgcttt gtttggctat atgctgaatc gttttgaatt aaaaccaatg ttgcagaagg 179581 cataaaaaaa ccgctcatag ggttgagcgg ttttttccgt atagccattc gagcgcgttg 179641 atgaactgtt tgcagaaata cttgtggtgg tgcaccgctc ctttttcaat tgaaagacac 179701 aactggtctt cagtgaagcc tttttctttt agactttgat gaacttgctt tgtttttttc 179761 agcatatgtc gctgaatgga ttgtttttca cggccttctt cactcccgat agacatgaaa 179821 acacgtgcag tgccgggctt taaagaagat atatgaatgg tttccgctgc gttctcgtac 179881 cagtatgaac ctgatataga gcctattttc ccgaacattg acggatattt taatatggcg 179941 aacattgaga tgaggccgcc taatgaggca ccgatcattc ctcttgactg cggttccctg 180001 gtgacgttcc agttttcttc gattagcgga atgaactggt tcgttatatc agacagatag 180061 tgatatccca ttccgccgaa gtccgtgaac cgatcactga gtgatgcagc cggccatggg 180121 gtgtattcat caagccggtt ttcgggttcg ataccgatca gcacgagttc agggagcctt 180181 tgctgttgaa aggcgctttc tagtaattcg atttggtttt ggaacaaaga actgccatcc 180241 tgcacgtaaa cagcaggaaa tcccccgctg tctgtgctgt aggaaggagg gaggtacagc 180301 gtgaacctcc tgttgccggc tttgtgttct gaaagagatc ctttcaagca ttctccccct 180361 ttttttgctt gaaaagcaga tataagaaat aaggaactcc gaggatcgcc aaaatgatgc 180421 ctgcgggcac ttctgcgggc tgaaaaaaca gttttccggc aaagtctgcg cttatcacaa 180481 gaagcatccc gattaaaccg ctcagtggca ggatatagcg atgttcgacg ccagccagtc 180541 tccgtgagat atggggagca attaagccga caaacgccat acttcccgct acggagacac 180601 aggcgctgat gattgctaca caggcaacga gaaggatggt tttttcttta tttgatgaaa 180661 taccgaggct tctgactgtg tcttcatcaa aacgaatggt gtcgagcagg cgggatttgc 180721 cgataagaat cggtataaac agcagcatcc atgggagtac agctgtaata tacgtccagt 180781 tggcagacca gatgcttccg tttttccaca ccatggccat ttgatagtct tgcgggtcca 180841 tttttaaaga taaaaacaaa gacagggcgc tgaatcctga attgatcgca atccctacca 180901 aaataattct tcctgaatct aaattgcctc tgtgccatgc aaatatgtaa atcaggatcg 180961 ccgcgatgag cccgcctatc aatccaaaga gcggcattcc catcgctgca gctatggatg 181021 tcacttcctt ctggccttgg aataagagca taaacgctac aatgccagct cctgcccctg 181081 cgttgattcc gagaattcca gggtcagcaa gcccgtttct cgtgatggcc tggataacag 181141 cgcctgcaat gccaagaccg agtccaataa tagcagccat gacaacccgc ggcagtctta 181201 aatcgaacag caaaatttca tactgcggat tcgggtcgat ttgaaaaaga gtggagagca 181261 gctcagcagg acgaacagaa aatgatccgc tcgttaagct gaaatagctg acaacaagaa 181321 tcaaagcgat gaacaatgca tattttttag ccattttgct cccctccttt tcgtttaatt 181381 aaataaagga agaaaggtac gccgataatg gatgttacga cctcaatcgg tgtttcaaac 181441 ggatagttga taaatctgct tgcgagatca cacagggtta aaaagattcc gcccaaaata 181501 caggaacacg gaatcagcct gctgtaatca gagccgacga gaaatctcgt gatatgcgga 181561 acaaccaacc cgacaaacgc aatttttccg gccagcgcta cggcactgcc ggttagaatg 181621 atgacggaaa gcatcgccat gattttaatg gtttttttct tttgccccag gcttttagaa 181681 atgtcgtccc ctaatgatac agcggttacc tttttgctga gagaaatggc cattataatg 181741 ccaatcagga aaaacggagc ggcaagcttc aggaaatctg gactcatttg atgaagtctg 181801 gcactgtacc agaaactgag atcctgagaa atttgaaaat aaatcgacat ggccgctgat 181861 aagctgctga gcagcatgct tgtgactgtg ccgatgatgg cgagctgcac gggggtaaat 181921 ccgtttggca tcatggcggc aaggccgaat actaacaccg ctcctaacgc tgagccgata 181981 aaagagtata tcatcatttc aatcgaagat gattgcggga gcagaaccat gcaaagcgta 182041 atgataaacg ctgaaccatc tgaaacaccc ataatggatg gcgaagctaa ataattgcgc 182101 gtaatgccct gcataagcgc tccagaaaca gcaagggctg cccctatgag cagagcgccg 182161 gcagcccttg gaatccggga atgccatata atttgatggt ctgtgtttcc cggatcgaaa 182221 tgaataagag atgtaaaaac aatatctgtg ctgagatgct ttgccccata aaggattgaa 182281 agcaaaagtg acagcgctat agcaaatgga gaagtaatca atatgatacg tgtccactgt 182341 tttgaataca tacaaaaacc tactctgaat tagttttgtg tcaatttttc agcagccgct 182401 ttcaggaaac ggactttgct ccaagctgtg ccgccttgtg cgagagggtc cactgagttg 182461 acatacacat ggtcttcttt gactgcttta aggcttttcc agattggatt tttctctaaa 182521 tcttttaagg catcaggttt gtctgcattt tcatcatcag aaaattggac gaaaatatgg 182581 tccgggttca tttcacttaa tttttctaat gaactcagct cttgcgcttt tgcagccttt 182641 acttcgttcg gcgccttaag gcctaaatca ccgtatagtg tggagttgaa atacacctgt 182701 tcagggtaaa tgtaaatgtt gccttgtctg attctgatga caagcgcttt tgaatctttc 182761 gctttatcgt tgatttttgt ttttatttct tttagatcct gttcatagtc tgcaataatt 182821 ttctttgctt ttttctcttt tccagtcagc tgggcaagaa gcatcatgtt ttccttccag 182881 tttgaagaga tatgagaaac tgggatcgtc gtgcctgctg tgctgatttt ttgcagcgtt 182941 ttttccggaa actttgttga agcaaggata acatctggct tcatttcaag aatcttttca 183001 atatttggct ccattttttc tccggttggt tcggctttat cagtgatgtc tttgaacata 183061 tcagggaatt tgccggagaa tgaaattgcg ccttgcggat gaacgtcaag caatttcgcg 183121 tcttccattg attcaacgct tcccgtaatg gcaattttgt ctgtcggtac agttacttca 183181 tatgttttat caaggtattc aattttcttc ttctcagatg ctgtgccgct tgccttgctg 183241 gcagttgatt catttttgct gccgcaagct gccgccgtca gcgcgagaag taagattaat 183301 aaggtaagag atatcttttt catctataga gcctcctgtt caattgataa ctattatcaa 183361 ttggaattat agagaatgaa cagatataac accatggaca aattcctgat ttatcatgga 183421 caatctccgg atagtaaaga aacagtttgc tgaacgatgc gttcgtgccc gcaagctgag 183481 tattcattcc acgggtcaag ggatagaaga taaacacggt tatctcgtac cgcgcttagg 183541 ttttgccatg cttctgtctg ctgtaattgc tggtagtaag ctatggtctc cggctcttta 183601 aaaagaaaaa gcatcataca gtcagcttgg taatttgcga tattttctaa cgaaatcgct 183661 tgttctgaag gtgtgtcagc cgttgttgcc gagctgaatc ctaaatcccc aaagaaaact 183721 tcgcggacac ttcggttatg agccagatag aagttttgct tatgcagcct caaaaagaga 183781 aaacgcagcc cttgaacgtg ctgaagtgtt tttttggcgg ccgttgtctg ctggtcataa 183841 tccgctagcc acttttctgc ttcggactcc tcctttaaaa atgaggcagt ttgcagaaag 183901 tgggttctcc agctttcttc tgaaggaagg tacatgactt ctgcgatgcg attcaggcga 183961 tcttgttctt ctggagaaat agaatccatg ctgacaatca catctggttc tgcctgtgat 184021 aacgtgtaca ggttttcttc ccacttttca ttaaaccggt atgcactgag ctggacgggt 184081 atatctgtcg aataatgctg atagtagtaa gacgtccatt tcggatgcag agcggccgca 184141 aaaggtatgt ggtgaagagg gatgagatgg cccattgtgc cccttccgta tgcggcgatt 184201 ttctttcggc gttttttcat atagcttgta ggtgaacagc ctgtatattt tttaaagatt 184261 ctgctgaaat aaaattcatc ttgataaccg gtttggtgtg cgatttcttt caatttgcag 184321 tttgattttg ccatgagccg ttttgccttt gtgattcgtg ttttcgtaat aaattctgtt 184381 acgctctgtc ctgtccattt tttaaagctt tcactgtagt gtttggcact gattcctgcc 184441 atttgcgaca gctgggcaag cgtgattttt gtatcggcat gggtttcgat atagtgtttt 184501 gttttttcga ttgctgaatg tgtatccgtt tgatcagata aactggcagt aaaaagatca 184561 taaatcaggc tttgtacttc aatcacacat tttagctgag aaagctgaga cgattcattc 184621 catagtgcgg caagctcttg aagccggact gcaagatttt cgatatgtga aacattcata 184681 agcttcagtt tggctaattc cgattctgtg cacggtgtga aaatatcttg cccggtttcc 184741 ttgatatagc ttagaagcct gattatacag gcatctatat gtccatcggc tgctggcgta 184801 aagccaaagg tctcgttagg cggacaaaca taaagtgtct ttttttgcag aggattggtg 184861 tttgttccga tcgaaatata gccgtttcct tttaaatgaa aaatcagcac gaatgaatcg 184921 gctaattgct gttctgagaa gagatcactt gtctttttta gatattcaat ttgtactggt 184981 tgataaatca ctgcattttg cacgagtaga ccaccttttc agaagctttc aattgataat 185041 cattttcaat aaaaattgta ccaaataaat gaaagttttc ctatataaag cgggtgggtt 185101 tttagcatga aaaaaaccct tacttatgtg taaaagtaag ggtctttcgt tcaataagaa 185161 tatgttacac gtgtaacata cgatgcttat gttctaataa atgagatact tttttcttgt 185221 tttgctgaat tgttggagtg ttttttcata gctgtttatg atgttctcaa ccgaagttcc 185281 attttcaatt tttgtcctga tccagccgtt gcctgccagt ttatcgaatg aacctgttga 185341 caggaactca aaatcctcag gatagagatc gtgtatggtt ttaatgactg aaagacccgt 185401 tttaacggct tcaaacttat ctctgtctgt cacatagagc tgcacaccgt ggcaaagcgt 185461 tccttgatgt ttagaaaacg tcggtgtgaa ggatgctgcc ctaaatgtaa cgcccggcaa 185521 atggaggctg tttaatgttt cttcaagttc tgtgcttttg ataaagggag ctccgatcaa 185581 ttcgaatggc tttgttgtcc ctcgcccttc ggatatattt gttccttcaa tcagcccggt 185641 tgcaggataa acaaatgtgc tttccaccgt cggcatgtta ggcgaaggga ggacgaaagg 185701 caatcgggta tcgtcaaaat ccatttttcg tttccagtgt ttcattttta ccactgtaag 185761 atcggcatca atactaaatt ctttgttgaa cagtgaagcc aattcgccta tcgtcatccc 185821 atgcttcaat ggaatgggat acaatccgac aaatgaggcg tattcaggtt ctaagattgg 185881 tccttcaata tgattcccgc cttgaggatt cggacggtcc agcaccataa atggaatgcc 185941 gttttcttta gcggcttcca ttgcgtatgc cattgtataa atgtacgtgt agaaacgggt 186001 cccgacatcc tgaatgtcaa acattagaat atcgacattt ttaagcattt ctggagtcgg 186061 ttttttcgtt tttccgtaga ggctgtatac gggaaccccg gttttttcgt caatgtaaga 186121 gcctacttcg tctccagcct gggcgtcacc gcggacgccg tgttcagggc cgaataaagc 186181 tgtcagtttg atatccgggt tctcgtaaag gatatcgaca ctgcttttta gagatgtgtt 186241 tactccggct ggattggtga tcagtccgat gcgttttccc ttgagctgtt ttttatagtc 186301 tggcaagagc gtgtctatcc cagtctggac tttaggtttt ttagctgttt gattctttga 186361 atcgggtgaa gcagaggcag cggttatcgt tccgaacatc atgagccctg tcagaaaagc 186421 gaatattgtt tttctcatgt gtccctcctt attaaagcgg tcttcccgtt ttgatattta 186481 atccgtagcc aagtgggtaa agggtgttcc ctggtttcgt gactgacgga atgtcaactg 186541 gaagtgtgcc tttaggtttt gcctggccga atatcgccat cactccggcc ggaatattag 186601 gttgaagata acggccattt gcgtatcctt taaagccata gactgcaatc agtgcttttg 186661 cttcttcgaa attggctgcg tcataggggt tgcgcaggct cattaagaca aatggtttgt 186721 tgtgctgcag tgcggctttc atgacagctc tcggaaacac ggtggcccat ttgcttgaat 186781 ctgatattgt gtcgtcgatg acaccgtcgt tgacgacagg gtcatttttg acgacatagg 186841 agccggtaat gatataatca gcctctttta cttgtttttc atgctcggtc ttaaatactt 186901 ggctggcaaa gttcattttg ctgagggata cgggtttgat tttctttcgc ttgatgagat 186961 cgtgaatggt ttgttcgatt gaagcagttt gttcttcgta aggtgccaca attaagattc 187021 ggctgccttt tttaggcttg aacggcaaag tgtgctgttc attttttaat acagttactg 187081 ctttttcagc taattttttc tctgctttca ggtgctgctt gcttcctacg atttttttgg 187141 ctttggctat tttttctttt gtactgtcgc tgtttcgcgc tggatacatg ccgcgtttta 187201 ttttcaggga aatgattctt tcaactgaat tgttgatttg ttgttcagga atatccccgt 187261 ttttcacggc ttctttcaaa gcttgaataa cacgtgcgaa tttctgttct tctttcaatg 187321 aagtgactga ggctggcatt aatgcaatat cgacaccagc ttttacggcc atgaccacag 187381 cctcttcctg tccgaaatga tctgcgattg ccttcatatt gagcgcatcg gtaacgatga 187441 ccccattaaa gcccatttcc tgacgaagaa gacctgtcat cacttttttt gaaagtgtag 187501 ctggaaccag aatgtccgat ccatcgagtt tgcttttgta agtggtgtca tcaaaggcgg 187561 gaaactgaac atgggctgtc atcaccatat cagcaccagc atcaattgct ttttgaaaag 187621 gataaagctc gacctcacga agccgttctt ggccatggga aacgagcggc agtccataat 187681 ggctgtcaac gtccgtgtct ccatgtcccg ggaaatgttt gagggcagac gcgatatcct 187741 gccgctgcaa ccctttcatc gtatataaac cgaggcgtga tgtcagttct cgattggagc 187801 tgaatgaccg tacgccgatt acaggattat caggattatt gttaatgtcc acgacagggc 187861 tgaaatctgt attgatgcct aaggcagaga gctcttttcc gatgatgctg ccggtctgat 187921 acgcattgat tctgcttctg gctgcgccca gcgccatatt ccctgggaaa ttagtgccct 187981 cccctaacct cgttacaatg ccgccttcct gatcaatact cagcatgagc gggatttttg 188041 gacttgcctt ttggtaatcg tctgtcagtt ggacagtttg ttttgttgtt tttacatttt 188101 ctgcaaaaag gatgatgcct ccgaattgat atttcttgac gaggctggcg acttcatcat 188161 tcatttttgt aagggcttgc ggagaggact cgccttcctt ttgccaattt ctaaaatcag 188221 gcatcagcat ctggccgagt ttttcatcta acgacatacg attgacaatc tgattggcat 188281 cgattgcacg tttggatgca gaggcttctg tctgtctggc cccgaaaaag catgaaagaa 188341 agagaacggc tgaaaggata agcggaaaga caggtctcat agaaacttcc tcctatcgtc 188401 taatcattca ctccatcgct tcataaatcg cggttatgac acttccataa ctgcctgttg 188461 gaaattggtc accttcaaag acgttcggat tttcttccgg atcaataact ggtgtatgct 188521 ttttatttgt taacaatgcg atgcctaaat tgtatgctgg atcaataatt gtaactgtcc 188581 ccgtccagcc ggtatgcccg taagcatttt cgctggcatg agggccaaac atccattcca 188641 tgcttttact tccgttccgc ctccagccaa gagcgaatgt cggatctgtt gctgaaggtg 188701 ctgtaaacag gtcggctgtt ttctgatcaa ataaagaaat gtttcggtat gaacctttgt 188761 ttaacatgac ttgcagcagt atggccatat catctgcatt tgagaacaat ccggcatgcc 188821 cagacacgcc gtccattgag taaaacgctt tttcgtcatg cacctctcct tgcagcgtgt 188881 ttgtgcggat gttagggaat tgaataacgc cgtcacgtgt attgcccatg cgttcagtag 188941 ctgcgaactg tttcggttta aagccctttt gcagcggatt gtacaaggta tgcttcagcc 189001 tgagcggttt gtagagctct tgctccgtgt agacatcaag cggtttgccg gtgagttttt 189061 cgacaataca tccgagtagc atatatccaa tgtcactgta tacgtgtttt gtcccggttt 189121 gataatcgag cggaattttc gtcaaatatt caatcgtttt gtcccgttct tgggaatagt 189181 acttgccggc tttttccggc gtgtaaaagt aaaagcttga tgggagccct gattggtgct 189241 ggaggacatc aatgacacgt atcttgtctt ttccttttat gaggtcaccc ggctgatcct 189301 tgaaacccgg caaatatgca gaaacttttt catagacgtc aagttttcct tggctgacta 189361 agcgctgcaa tgcaaaattt gttgcgtaca tttttgtatt tgaggctaag tcaaacatcg 189421 tgcgggtttt cattttggcc ggacggcgca gcagttctga tccttcgtac tttttactgt 189481 agccgtatgc tgcttttttt atgatgcgtc catccttcac caccacaaga acggcgcctg 189541 gaaatcctgc tgcaatatcc cgttctatca tctgatctac cttccttagc ttcttcgtcg 189601 agaattgtgc agtttctgca tttatgattt tcggctcaat caagttgcct gctgtttgtg 189661 cgaaggtttc atttggcgca aatatcgata gggttaaaat ggcactgaat atgaacagtg 189721 tctttgtttt cacaggctag cccctttctg tgcttctatc ccgtttacta tccctaaaac 189781 agaaacaatt taatcgaact gagaagccat ttcatcttta tatccgaatg cataggtcaa 189841 taaaaaaccg gccgcgtagg aaataaagag cccaacgata tacaggatga tttgcgaagg 189901 caggactaga aaagatagcg gcagtccgga gacaccaatc gcaatggtgg ctacttgaaa 189961 ataagcttga aaggcgccgc cgattccagc tcctaaacat gctgttaaaa acggacggcc 190021 aagcggcagc gtgactccga aaataagcgg ttcaccaatg ccgagcagtc ccgatggaag 190081 cccgccggcg attgctttcc tcagtgttgt ttttttcgtc ttcacgaaaa cggcaaaggc 190141 cgcgcctacc tgtcctgcac ctcccatagc caaaataggg agcagaggat cattgccaat 190201 tgaattgatc agttccatgt gcacaggcgt caagccttga tgcagtccgg ttacgacgag 190261 aggaaggaag gttgcgccca gaataaagcc cgcagcgatg ccgccgatgt ccaggatgga 190321 cagtaggccg gatgtaatag catcagaaat gaatccgcct aaaggcataa atacgacata 190381 cgttacgatt ccggtgatta acagtgaaac ggtgggtgtg acaatgatat caagtgattg 190441 aggaataaaa cggcgaataa attgttcggt gtaagcaatg aatatggctg cgaaaaggac 190501 gccgatcaga cctcccctgc ccgggagaag ctcttctcca aataaactga tttttgcgat 190561 ctccggattg ataatcaaga tcccggccaa agccccaagt gcgggtgtcc cgccaaattc 190621 tttcgaagcg ttaataccga cgagaatgcc gagataagtg aacagccctg atccgatgac 190681 tgtcaggata atcgcaattt gtgagtctgc agagagccag cctgcttgaa taattgcttt 190741 ggtaatccca gtaattaaac cggaagcgac tagagcggga ataagaggga taaaaatgct 190801 ggcaatttta cgtaagaaaa gtttaaaagg agtggcattt ttccgattga tatcggcttt 190861 ctttttggcc gctgcttctt tgacatcggc accttcttct gctgacacga gctttgagaa 190921 agcagctgta acatgattga caactcctgt gccgaggata atttgtaagg tttcagcttc 190981 aacgaccccc aatacgccgt caagctttct taaagcctga gcatccgctt tgctttcatc 191041 gtaaggcgta atgcgcaggc gtgtcatgca atgcgtatat gaagaaatat tggattttcc 191101 tccgcatagc tcaaggattt tctgtgcgag atgatggtag ttattttctt tgctcattaa 191161 aacccctccc cttcaagatg ccttatttta ttctcataga ttgtatggct gctctcgttt 191221 tatctatata accggttgtc gtttcatact gctcagccgc catgcctaaa aacaaaacat 191281 caattataaa aagctgggcg aggcgggaag aagtggctgc acttcgaatc aaggcttcat 191341 tggaatgggc tgtatacaaa gggacatcag ccagtgcgga gacggatgtc tgactgaatt 191401 gtgtgaggct gatcgttgtg atgccttttt ccttagccat ggcgaacagt tcaacgattt 191461 cctgtgtctc tcctgaaaac gaaatggcga atacgatgtc gtctttatct gcatttgcga 191521 ttaaagatgc cacaagatga gtgtctgtaa acgcggttgc ttgtttatga atgcgaagcc 191581 acttttgctg ggcgtccttg gcgacaatgc cggaagcccc gaggccgata aaatgcacgg 191641 tatgagcttt gagaagcaga gaaaccgctc gttcaagctc tttgtagtcc atcaggtctg 191701 aagtatcctg aatggcttga atggcattgc cggccgtttt ttcggaaatg gagggcagcg 191761 gctcgtgggg aacaatatcc cggtagccct gaaacgtagg ctttgccaga tcgcctgcta 191821 ctctcatttt taaatcttga aatcctttta aaccgagtga tttgcagagc ctgatgacgg 191881 cagcgtcact tgaattggct aaggcgctga tttcgttgac cgtgctttcg attgctttgt 191941 ggggatgggc taggatataa tctgcaagtt tgcgctcgga tggagggagc ttatgcttca 192001 ttgattggat gatcgctaaa ccgcctgtgg ccattctagt tctctcctta tcatggatgg 192061 taatgttcga ttgctttgtc aatgaaaccg tttgcttcat cgagtaatgt ctgtgcttgt 192121 ttctgatctg tgcttgtttt gagcatgacg attgctgttt tgacgtgatg atcggcttgt 192181 tccagagtgt atctggctgt gtcgtatgaa gcgtttgtaa ggctttggat gatgctgatg 192241 gcgcgttctt ttagtttttt gttgctgacg ttgacgtcta ccatcaagtt ttcgtaaacc 192301 ttgccgattt tgaccattac agcggtagat atcatgttta gaatcatttt atgagcggtt 192361 gcggctttca tacgtgttga tcctgtaatg gcctcaggtc cgacgacaac ctcaatgctg 192421 tgatccgcat ccttgctgat ggcggaattt tcattgcaag taagggcgat ggtgtgtgct 192481 ccgactttac gggcgtatct tagggcgcct gcggcgtagg gtgtgcggcc gcttgctgcg 192541 atggcaatga cggtgtcatt tgaagtgagc tgtatgtttc ttaaatcttc agctcctgct 192601 tcttcactgt cttcaatgcc ctctgctgcc tgtaaaaagg cttcggggcc tccagccatg 192661 attccgatga cctgatctgg gcttacgctg taggtgggag gacattcaac agcatccatg 192721 acgccgagtc tgccgcttgt gccggcgcct gtatatatga gccggcctcc attttgaaac 192781 gattcatatg cgcagtctac agctgttttg atgtcgggga gaacctcctg aacggctgca 192841 gcgactttca tatcttcgtt gttgatcatt ttaaggatgc cgagagtgtt tgctttgtgg 192901 atttcaactg tttgactatt gcgtgattcc gttgtaagac ggtgaaggtt taatggttct 192961 gacatgagga tgccccctgt tttaaaatga tatatctcaa tattcagtat attcatttct 193021 gttatgatat ttcaactatg tttttaaatt tttgaaattt tatttcactt aagactataa 193081 gaaatgatga aggatcaact gttctccaag cggcccgatt cttcgccgtc ctttatcaag 193141 gaacccgctt ttcatataaa ggtgttttgc gcgtatgttc agatgattga cggccaagat 193201 gatttcgtcg caccatggaa aatatccgct cacaaaagcg ggaagcaaaa gcatggcttt 193261 tttcgcatag ccttttccgt gatgcacagc ggttaaagac agggagctga gcagtaaagc 193321 aaatggattg ttagaatagg aagcaagcgt ttcttttgat gcatgtaaaa tgaaaaaacc 193381 gactggaagg tcgtctttta agatgacaac cgggtatcgg tcctgtatgc ccagagcctg 193441 agacagcacc tctttcggga gggaggtaaa gcgtttgtca tcgttggtga gcgtgaatga 193501 ttggagctcg ggcaagtgtt caggcttata gaaggataaa gaaatgtctt gagtcatggg 193561 gtggcctcct tacaatatgt cgttaagctc gttttccgaa atgacgcggt agcccgcttg 193621 ttttaacagt gcggcggtta ctccgctgcc ggtgattttt ttgccagaga atgtgccgtt 193681 atagataaaa ccgcttccgc aagatggact gttttctttt aatatgacgg cagaagcgtt 193741 gatttctttt gcgtaagcca atgttttcgc ggcgccttcc atatatagtt ctgtgacgtc 193801 ttctcctgaa gctgtcacga ttttcgctgt tccattgagg acatcctcgc cagtgcctcc 193861 tatgatttct gcgggttcgc gtggggtaga gaagccgccg agaagttcag ggcaagccat 193921 gactgctttc ttttcatcga ctagttttct gattttctcc gacgctgcgt gagagccgtt 193981 atatctgcat tcaatgcctc caaggcaaga actgactaga atcatattgg tttctcctct 194041 cttgctttgc ttgtctctat cataaaataa atggctttag ttgggaggct ttttcagtta 194101 aaaaaggagt taaaaagttt gaaaataaaa aatttaattt tcctctttac aaacaggggg 194161 tgacctgtat ataataactt ttgtcagctc gacgagaaca caacggcccg ttggtcaagc 194221 ggttaagaca ccgccctttc acggcggtaa cacgggttcg aatcccgtac gggtcaccat 194281 ttggaggatt agctcagctg ggagagcatc tgccttacaa gcagagggtc ggcggttcga 194341 gcccgtcatc ctccaccatc ttgccggtgt agctcaattg gtagagcaac tgacttgtaa 194401 tcagtaggtt gggggttcaa gtcctcttgc cggcactgtt ttttcaaaat tttatgtgga 194461 ggggtagcga agtggctaaa cgcggcggac tgtaaatccg ctccctcagg gttcggcagt 194521 tcgaatctgc ccccctccac cattattggg ctatagccaa gcggtaaggc aacggacttt 194581 gactccgtca tgcgttggtt cgaatccagc tagcccagtc acagacacct ttgatcaaaa 194641 ggtgtctttt ttcttttcgg aaaaatcatt ccaacttcta actgttcagt ctgtataata 194701 attttaaaaa tatgttaagg tagtttattc acgaattacc atctacaccc tgccaaaaat 194761 ttgataaact tattttataa aaaaattgaa accttttgaa acgaagctcg tatacataca 194821 gaccggtgaa ggcagaggtt agataaatat ggaaatgatg attaaaaaaa gaattaaaca 194881 agtcaaaaaa ggcgaccagg atgcatttgc ggacatcgta gatatttaca aagataaaat 194941 ttatcagctt tgctaccgta tgcttggcaa tgtgcatgag gcggaggata ttgcacagga 195001 agctttcatc agagcgtacg ttaatatcga cagttttgat attaaccgga aattttcaac 195061 ttggctttat cgaatcgcga ccaatttgac cattgaccgc attcgcaaaa agaagccgga 195121 ttattacctc gacgcagagg tggctggtac ggaaggcttg accatgtatt ctcaaatcgt 195181 cgcagatggt gttttgcctg aagatgcagt tgtatcgctg gagctctcaa acacgataca 195241 gcagaaaatt ttaaagcttc ctgacaaata cagaacagtc atcgtattaa agtatattga 195301 cgaactctca ttaattgaaa tcggggagat tctaaacatt cctgtgggga ctgtgaaaac 195361 gcggattcac agaggcagag aggctcttag aaaacaatta agggatcttt aagtggggtg 195421 atgaaatgag ctgtcctgaa caaattgtgc agcttatgca tatgcatctt gatggagata 195481 tccttccaaa agatgaacac gtattaaatg aacatctgga gacatgcgag aaatgcagaa 195541 agcattttta cgagatggag aaatccatag cgctcgtacg gagcacatcg catgtcgaag 195601 cccccgcgga ttttaccgct aatgtcatgg caaaattgcc taaggagaag aaaagagctt 195661 ctgtaaaaag atggttcaga acccatcccg ttatcgcagc tgctgcggta ttcatcattt 195721 tgatgggcgg gggttttttt aacagctggc ataatgacca caatttcagc gtgtccaagc 195781 agccgaatct tgtggttcat aaccatactg tgaccgtgcc agaaggtgag acggtcaaag 195841 gtgatgtcac tgtcaaaaac ggcaagctga ttattaaagg caaaatagac ggggatgtaa 195901 ccgtcgtaaa cggcgaaaag tatatggcct ctgctggaca agtcaccggt cagattgaag 195961 aaatcaatca gttattcgac tggacatggt acaagatgaa gtctgcgggg aaaagtgtac 196021 tcgatgcatt caatccgaac ggagaagagt aaagcgcgtt agccgctttg ctcttttttt 196081 gcgggctgag agggctggca catttcactt gctaaatcga aatgtggtat aatgggctcg 196141 ctatgtaaag tacatatgcg taacacgtaa aacacaaaat acgaaatgac tgaaatcttg 196201 gaggacgagg aaatggcttt tgaggatatc ccttttttgc agtacctcgg caatgccgtt 196261 gatattctcc ttgtttggta tgtgatatat aaattgatta tggtgatacg cggcacgaaa 196321 gcggttcagc tgttaaaagg aattgtagtc atcgtgcttg ttcgtatggc cagccaatat 196381 ttgggcctca gcacacttca atggctgatg gaccaagcga taacatgggg atttttagca 196441 attattatta tttttcagcc tgagctgaga agagcgcttg aacagctagg ccgcggccgc 196501 tttttttcga ggagcggcac gcctgttgaa gaagcgcagc agaaaacgat tgaggccatt 196561 acaaaagcaa tcaattatat ggcgaaacgc cgtataggcg ccctgctgac cattgagcgg 196621 gatactggaa tgggcgatta tattgagacc ggcataccac taaatgccaa agtcagctct 196681 gagctgctga tcaatatttt tattccaaac accccgcttc atgacggtgc ggtaattatg 196741 aaaaataatg aaattgccgc ggccgcctgt tatctgccgc tttctgagag cccgtttatt 196801 tcaaaagaac tgggcacgcg gcacagagca gctgtcggta tcagtgaagt aacagacagt 196861 ttgacgatta ttgtgtctga agagaccggc ggcgtcagtg tggcaaagaa cggcgacctt 196921 cacagagagc ttacagaaga agcgctgaaa gaaatgcttg aagccgagtt taagaaaaac 196981 accagagaca cttcttctaa ccgctggtat tggaggggca agaaaaatgg ataaattctt 197041 aaacaaccgc tgggctgtga aaattattgc tctgcttttc gcgctcttgc tttatgtggc 197101 ggttaacagc aaccaagcac cgactccaaa aaaaccgggt gaatctttct ttccgacatc 197161 aacaactgat gaagcaactc tgactgatat tccggttaaa gcgtattatg atgatgaaaa 197221 ttacgtcgtg acgggtgttc cgcaaacggt taatgtcacg ataaaaggct cgacaagcgc 197281 cgtgaaaaag gctcggcaga ccaaaaactt tgaaatatat gccgatatgg aacatttgaa 197341 aaccggcaca cataaggttg agcttaaggc caaaaacgtg tcggatgggc tgacaatctc 197401 aattaatccg tctgttacga cagtgaccat tcaggaacgg acgaccaaaa gttttcccgt 197461 agaagtggag tactacaaca aaagcaagat gaaaaaaggc tattctccgg agcagccgat 197521 tgtcagtccg aaaaatgtgc agattaccgg atcgaaaaat gtgatcgata atatttctct 197581 tgtaaaagct tcagtgaatt tggaaaacgc agatgaaacg attgaaaagg aagcgaaagt 197641 gactgtctat gataaagacg gaaacgcgct tcctgtcgac gtggagccct cggtcatcaa 197701 gattaccgtt ccggtgacaa gcccgagtaa aaaagtgccc tttaaaattg aacggacagg 197761 aagccttcct gacggtgtca gcatagcgaa tattgaatcc agccccagtg aggtaacggt 197821 ttacggctca caggatgtgt tggattctct tgaatttatt gacggcgtca gcctagattt 197881 aagtaaaatt aacaaggatt ccgatatcga ggcagatatt ccgcttcctg acggtgtcaa 197941 aaaaatctca ccgtcaaagg tgactttgca tatagaagtc gatagtgaag cggatcagaa 198001 gttcgagaat gtccctatca agactgtagg gctgagcagc tcacaaaaca ttgaatttct 198061 tgatcctgaa tcacaagcga tagatgtaac ggctaaaggc tctcccacga atataaataa 198121 actgaaaaaa tcagatattg aattgtatgt gaatgtttca gatttagagg acggggagca 198181 tagcgtgaag cttgaagtga acgggccaca gaatgtaact tggtccttgg ggcggaaaaa 198241 cgccaaaatc aagctgacgt ctaagaaaag caatacatca acgaatgata acagcagcaa 198301 tacatcaggg aaccaggaca cagataaaca aacaaatgat caaaagaaca atcagcaaga 198361 agatacaaag aacactgata aaaacaacaa cgatcaaaac caagacggaa ataaagatca 198421 aaaccaagat caggatgagg atgaatccac tgcgaattca caatcctcat cggaataaaa 198481 aaggagcgat tataaaatgg gcaagtattt tggaacagac ggtgtaagag gtgtcgccaa 198541 tagtgagctt acacctgagc tggcctttaa agtcggacgt ttcggcggtt atgtgctgac 198601 aaaagacaaa caacgtccaa aagtgctgat aggccgcgat acacgcatct ccggccatat 198661 gctggaggga gcccttgtcg ccggactttt atccattggc gcagaagtca tgcgcctggg 198721 tgtcatttct acaccaggtg tatcttattt gacaaaagcg atggatgcag aggcgggcgt 198781 catgatttcc gcttctcata acccagtgca ggataacggc atcaaattct ttgggggaga 198841 tggatttaag ctttctgatg aacaggaggc tgaaattgag cgcctgatgg acgaacctga 198901 ggataagctg ccaagacctg tcggagcaga ccttggactt gtaaacgatt attttgaagg 198961 cggacaaaaa tatctgcaat tcttaaaaca gacagctgat gaagatttca caggcattca 199021 tgtggcattg gactgtgcca atggcgcaac gtcatccttg gcgacacacc tgtttgctga 199081 tttagatgca gatgtttcta caatggggac ttccccgaac ggattaaaca ttaatgacgg 199141 cgtcggttcg actcatcccg aagcgctcag cgcgtttgtc aaagagaaaa acgcggatct 199201 cggtcttgcg ttcgacggtg acggcgaccg cctgattgct gtcgatgaaa aaggaaatat 199261 tgtagacggc gaccaaatca tgtacatatg ctcaaaacat ctgaaatcag agggccgttt 199321 aaaggatgat acagtggttt caaccgtgat gagcaacctc ggcttctata aggcgctcga 199381 aaaagaaggc atcaaaagcg tgcagacagc tgtcggcgac cgctacgtag tagaagcaat 199441 gaaaaaagac ggctacaacg tcggcggaga gcagtcagga catcttattt tccttgatta 199501 caacacgaca ggggacggat tattgtctgc tattatgctg atgaacactt taaaagcaac 199561 aggcaagccg ctgtcagagc ttgcagctga aatgcagaag ttcccgcagc tgttagtcaa 199621 tgtgagagtg actgataaat ataaagttga agaaaatgaa aaagtaaaag cagttatttc 199681 tgaagttgaa aaagaaatga acggcgacgg ccggattttg gtgcgccctt caggaactga 199741 accgctcgtc cgtgtcatgg ctgaagcgaa gacgaaagag ctgtgcgatg agtatgtcaa 199801 tcgcattgtt gaagtcgtcc ggtcagaaat gggattagag taacgaagtc tattatcaga 199861 gagtgaacaa gacaagcgag gtttacataa gataattgtg agacatacgg caaagttgct 199921 taaaaaacaa ttgaccgttt atgccacatg ttgtaaaatc aagcttgtct tgttcttatt 199981 ttctcaatag gaaaagaaga cgggattatt gctttaccta taattatagc gcccgaacta 200041 agcgcccgga aaaaggctta gttgacgagg atggaggtta tcgaattttc ggcggatgcc 200101 tcccggctga gtgtgcagat cacagccgta aggatttctt caaaccaagg gggtgactcc 200161 ttgaacaaag agaaatcaca tgatcttcca aaaaacatgt aggaggggac gattgaaagt 200221 ccccttgaaa tttgactttc ttcgtctcct tttacaatct taggaggaag aaaaatatgt 200281 gtggaatcgt aggttatatc ggtcagcttg atgcgaagga aattttatta aaagggttag 200341 agaagcttga gtatcgcggt tatgactctg ctggtattgc tgttgccaac gaacagggaa 200401 tccatgtgtt caaagaaaaa ggacgcattg cagatcttcg tgaagttgtg gatgccaatg 200461 tagaagcgaa agccggaatt gggcatactc gctgggcgac acacggcgaa ccaagctatc 200521 tgaacgctca cccgcatcaa agcgcactgg gccgctttac acttgttcac aacggcgtga 200581 tcgagaacta tgttcagctg aagcaagagt atttgcaaga tgtagagctc aaaagtgaca 200641 ccgatacaga agtagtcgtt caagtaatcg agcaattcgt caatggagga cttgagacag 200701 aagaagcgtt ccgcaaaaca cttacactgt taaaaggctc ttatgcaatt gctttattcg 200761 ataacgacaa cagagaaacg atttttgtag cgaaaaacaa aagccctcta ttagtaggtc 200821 ttggagatac attcaacgtc gtagcatctg atgcgatggc gatgcttcaa gtaaccaacg 200881 aatacgtaga gctgatggat aaagaaatgg ttatcgtcac tgatgaccaa gttgtcatca 200941 aaaaccttga tggtgacgtg attacacgtg cgtcttatat tgctgagctt gatgccagtg 201001 atatcgaaaa aggcacgtac cctcactaca tgttgaaaga aacggatgag cagcctgttg 201061 ttatgcgcaa aatcatccaa acgtatcaag atgaaaacgg caagctgtct gtgcctggcg 201121 atatcgctgc cgctgtagcg gaagcggacc gcatctatat cattggctgc ggaacaagct 201181 accatgcagg acttgtcggt aaacaatata ttgaaatgtg ggcaaacgtg ccggttgaag 201241 tgcatgtagc gagtgaattc tcctacaaca tgccgcttct gtctaagaaa ccgctcttca 201301 ttttcctttc tcaaagcgga gaaacagcag acagccgcgc ggtactcgtt caagtcaaag 201361 cgctcggaca caaagccctg acaatcacaa acgtacctgg atcaacgctt tctcgtgaag 201421 ctgactatac attgctgctt catgcaggcc ctgagatcgc tgttgcgtca acgaaagcat 201481 acactgcaca aatcgcagtt ctggcggttc ttgcttctgt ggctgctgac aaaaatggca 201541 tcaatatcgg atttgacctc gtcaaagaac tcggtatcgc tgcaaacgca atggaagctc 201601 tatgcgacca gaaagacgaa atggaaatga tcgctcgtga atacctgact gtatccagaa 201661 atgctttctt catcggacgc ggccttgact acttcgtatg tgtcgaaggc gcactgaagc 201721 tgaaagagat ttcttacatc caggcagaag gttttgccgg cggtgagcta aagcacggaa 201781 cgattgcctt gatcgaacaa ggaacaccag tattcgcact ggcaactcaa gagcatgtaa 201841 acctaagcat ccgcggaaac gtcaaagaag ttgctgctcg cggagcaaac acatgcatca 201901 tctcactgaa aggcctagac gatgcggatg acagattcgt attgccggaa gtaaacccag 201961 cgcttgctcc gttggtatct gttgttccat tgcagctgat cgcttactat gctgcactgc 202021 atcgcggctg tgatgtggat aaacctcgta accttgcgaa gagtgttact gtggagtaat 202081 aattaattaa cccctttgga taagaaggtc ttcacatgtg ctgctaggct ccaaatgtac 202141 acctttccgt aagggcaaag tcaaatgtga aaaaaaactg ttccaaagtt aatcagaaat 202201 ttattttcat attgtatcct tcggtatcaa gtgaaaggag catcatatga aaacattatg 202261 gaaagtcctc aaaattgttt ttgtcagctt ggctgctttg gttttgcttg tatccgtctc 202321 ggtatttatt tatcaccatt tccagctaaa taaggaggcg gcactgctga aaggtaaagg 202381 cacagtagtc gatgttgacg gtaaaaagat gaatgtgtat caagagggaa gcgggaagga 202441 tacgtttgtg tttatgtccg gttcgggtat tgctgcgcct gcttatgaaa tgaaggggct 202501 gtacagcaag ttttcaaaag aaaataagat tgctgttgta gatcgggcag gttatggata 202561 cagtgaagtg tctcacgatg acagagatat tgatacggta ttggaacaga cgaggaaagc 202621 gcttatgaaa agcggaaata agcctcctta tattttaatg cctcattcga tatccgggat 202681 tgaagcgatg tattgggcac agaaatatcc taaggaaatc aaggccatta ttgcgatgga 202741 tattggattg ccccagcagt acgtcacgta taaattgagc ggagttgacc gattgaaagt 202801 gagagggttc cacctgttaa cctcgattgg ttttcatcgg tttatacctt ccgctgtata 202861 taatcctgag gtgattcgac agtcgttttt aactgatgaa gaaaaagaaa tctataaagc 202921 cattaacttt aagcaatttt ttaatgcaga tatggagcat gagcttttac agtcttacca 202981 aaacggcagc aaatctgtga atctgcctgc gccaaaggaa actcccgtct tgattttaga 203041 tgcagtctct gaccaaaata gacattcaaa gtatgctata caaaaccgaa aagactatga 203101 agcgtttgcg gctcaattca atactgccga tataaaggaa ctgaggggaa cacacagtat 203161 ttatttatat cagcctgatc aaatatataa actgtccatg gagtttatga gaaaggttcg 203221 ctaggatgaa gggttatcgt attttaatcg ttgaggacga tgtgatgatt ggtgatttgc 203281 tgcaaaagat tttgcagcgc gagggatatc gtgtgatatg gaaaacagat ggagcggatg 203341 tgctttcggt gattcagaag gtggatttgg tcattatgga tgtgatgctg ccgggtgaag 203401 acgggtatca aatgtctgca aaaatcaaaa agctggggct gggcattccg gttatttttc 203461 tctcagcccg caatgacatg gacagcaagc ttcaaggttt gcagatcggc gaggattata 203521 tggtaaagcc ctttgatccg agagagctgc tattaagaat gcggaatatg cttgagcatc 203581 attatgggac ctttacgcaa atcaaacatt tgtatattga tgcggtaacg aaaaaagtgt 203641 tcaatgaaag cctgcatgat gaggtattat ttactgcgat tgagcggaaa attttctttt 203701 atttatatga aaatagagac agtatcctga caaaggaaca tttctttgaa tatctatggc 203761 agctcgaaga tagaaacccg aatattgtca atgtgcatat taaaaaaatt agagctaaaa 203821 tcaatgatca agcgggtgag atgattgaaa atatatatgg agaagggtat cggctgaata 203881 ccgttgtgaa gaaatgaagc tcaagacaaa atatcagttg ttattgttta cggccgtcat 203941 tagtgttccg atgctattgc tggcggtcag tgttttgatg tcggtgattt atgacagcat 204001 gtttaaaccg atgaatcatg gtatgccctt tcacaggtcg tttgcatacc cggcaatgat 204061 cgttgtattt ttgatatcac tcttattgtt agctttttta ttttcaaagt cgattcattc 204121 tctgttgcat aaaatcaatc tattaaatca aaccattcgg catttggcga gtgatcaaag 204181 ggtgcccgat aaaattgaag tgaagcgtgc tgatgaaatc ggggaactga tcaagtcggt 204241 caatttgtta attgaacgga cgacatatcg tgaactggag ctgagacagc aggaggaaat 204301 caaaaaggag cttttgcaaa aactgcggca tgacattaat acacctttaa cggctctcag 204361 gctgcagtta ttttatttgg aagaccaatg tcatggtcag gctgtattcg aatcattgta 204421 tcagcaaatc gaatatatct cggaattaac taatgaattc aatctatatt ccgctgagac 204481 gctggaaagc tcttatattg taaatgaaga agtgcgtcta aacgagctat tagaaacagc 204541 ggtgaaaaag tgggattatt tatacagtat gagtgggatt gagctgcact ataagccggc 204601 agatcaagat gtgatatgga tgagcaacac gttatggatg gaaaggctgt ttgataatat 204661 ttttcaaaat acgttaaggc attcaaaagc taaaaagatg gaagtcacga ttgaacatgg 204721 cgatgttttt attcgtgatg acggtattgg atttgatcgg aatgagagca gtgagggact 204781 tgggttaaag attattgagg atacatgcag gctgcttgcg attacttatg agctgcatac 204841 aaatgataac ggaacggggt tcttgttttc aaaagagtga ccccgctgat gtttttcttt 204901 ctcctataaa atttatataa tagggagaaa gaaatggggt gaacatcata tgtttaaaaa 204961 aatcatcaaa acgattaagt acctctcaag cagttctagt gaccgatatc gcagacaccg 205021 gcattacagc agcagccggc gcagacatta tcgcagctac agcagcagtt cgggcaaaag 205081 aagacactac gaccgttatg gcggcagtca tcgttacaaa cgccggagct acagcagcag 205141 ttaatccaaa aaaagttctt gttccgcttt tgggacaagg gtttttttat gtgaccgatt 205201 gaatggcccg gtttagatcc tcgcgaatgg aagcggtgtg ctgatactct tcctcaatgc 205261 ccaataatct tttcagcagc aaggttactt cctttgtcag tgttaattcc tccagccaag 205321 tgccgttttt cttctttttt cctttatatt gagagtacag caagaataac agcgtttctc 205381 cgagatcgaa gaagtcatcc tgttttcgta cctttatttc ctccatttct tcaggagtca 205441 attgtttggc aaggccgaaa tcgatgaggc agagcctgcc atcattgatg atgatattag 205501 gcgttctgat gtcgctgtgg aagataaggc gatcatgcag gtattctata atctcaagca 205561 gctgcgaaat cagttgtaac gccataagct ctgtgaacgg ctgttttcga aaaaataata 205621 attcttctat attctctccc tcaatgaact gcatgacata ataagcctgt ccgtctatga 205681 tgaattcatc tatgaagccc ggaatttgcg ggtggtgaat gtttttgagc agttttattt 205741 cctgctggaa tcggactttc tctttttcct ttttggcttt tgtcggccga agctgtttta 205801 agacataagg tgtttgagct aggatatcgg tgcacaaata aaccaaaccg tagcctccca 205861 taccgaggca ctcttcgatt ttgtattgat gatttaagat aacgccgttc tttagagggc 205921 ggtcaaatag cagttttttt agaagtttta atgccatgtc tgcacttccc ttggttgtac 205981 tgactatagt ttaccttcta gacggagaat aaaaaagagc cggataaccg gctcggtata 206041 agttaaaact gctttgtcac gtcgtattca taatctattt ttgcttttac gttgctcatc 206101 gtcgatctgg ctgtcgctaa tgtattatat ttaaaactcc atacctttgc cacactgagt 206161 tgatccgaca aagagatatc ataagaccct gaagtcgagc tgtttacaag ggcacggctc 206221 cattcgttat tttcgcttgt catgatcaga tggcgtgtat ttccctggct tggtgtttga 206281 gtggcggttg tttgaactct ggttacaatg gcatcacgcg gtatcccaga ttggtttgtt 206341 aaatcaacct tgatcacgct ggagtcagaa cctgaggggc taaggcttgt atttccttta 206401 ttttcagcaa cgccgctgaa ttggaacgtt ccgctgcctg atttgattcg gtcttcaatt 206461 gaaagcgtaa agtacatgtt tccagtatag gtgcctcgtg acactttcac atagaaggta 206521 tccgtcgtgt tttgggcgtc tgcatttgca taaataaaag aagaaaacgt attagggtta 206581 ataacttctg tcccttgaga aacaggtatt ctgttcttgt cataaatttc aattttcatc 206641 cctgtatacg cgctctggta tgtactcctc atgtatactt tttctccctt attagccgta 206701 aaagtgaaat aggcttcatc ttgaccagct tccagtattg ttgtatcgat atttttatat 206761 ttccaataac cgatcggcat tgcggtatca aatgaattgt ttcctgtgat agcagtgact 206821 ccgacagctg atgccgaata cgtaaaggta gataagacag aaagcataac agcgaattga 206881 ataagccatt ttttcaccat gcaaacaacc tccttttatt tccatcatac ataataacga 206941 tttaggtgta aataaatgtt ttttgaggtt aatatataca ttatattcgc cgataaaaaa 207001 gaataagaga gaatactcgg gagggaattc aatgcgtctg aatcggcaat ttatccgcac 207061 tcagctgatt gcacagaaca tattgagcaa gaatgcgcct gccaaacggg agaatgcgac 207121 tgaaaatcca gcggcagttc tggaaaaggc atatagcagg cttaagtcac aatcttcaac 207181 tgggggaatc aatcagttca attattctaa aaccagcgtg tcgggaaaca gcgggacgtt 207241 cagcaaagtg tatcaatcag cgaatgatcg aacagtgaca gacacagggg aagaaacagt 207301 gattcaatcc caaaacccct atgaatctga gagtgatatc agaatcaaaa tactagatga 207361 aaaatacagc aggatgaatg cgattaataa aacaaagtct gatccattag gctatattaa 207421 ggataagtac caaaattcaa agtctcctta tttcagaagt gatctgtcag ctgcagaaag 207481 acaggccgct tacgataatg aaacagaatg gttattcaaa gggaaggcgc aaaactataa 207541 ccttcaggat gctgtgtttc ggaatgtcac atttcatggg gaagtggaag ctgagaatga 207601 aaaggtgtat cagcggggac aggttaacca gcagctgcaa gtactgttga atcgaaacca 207661 tattcatatt ccagagggga cagagctgac gtttacaatc acaccgattg actatcaggt 207721 gcgggtaagc gggacagacg atcaggatct gatcaagcaa attgagcaag tgctgcaatc 207781 tggagacaac agcaaagaac tatttttaca catcatgaaa agtcaaagca gtgattcagc 207841 acaattttcc gaagaggcct ataaaaagta tcaggcagct cgtgagatgt atgaagttac 207901 aggctaccat ttgaaggatt tagaagtgat tgatgggcgg tacgtcacgc ctgagggacg 207961 tgacttaatg gatgtatata aggaagagct tgaaaaagat ccagtgcaga aacaaacggc 208021 ttcttatgct atatcttact atcgttcaga gctcagtaaa atcgcggaag ccgggtataa 208081 tgccattccg gatttcatcc tatcaattga ttacagcaat ggatctctga gagatgtggg 208141 acaaagcaag agctatggga ccggagatac cgggtggctt gaagcattaa agcgtcaaac 208201 gggtgtgaat tattaggtaa gctgttcatg taggacagct tattttttat gagaatctaa 208261 ggggtgaatt aatcccaata ttcaaataat tttattattt ttatataaaa gattttaaaa 208321 gaagtgaacg attcaaaact ctgaacaaag gtgtttacct gaaaaaaaca attgtatttt 208381 ccagagaaat ttattatgat gaaataagta atttaggaga ttatataaca attttaagtt 208441 tgaattttct gattgttatc actgattcat gtgaaggcaa gcaggtctgc tgttttctca 208501 tttatgagta ttttgttagg aggaggaaga ggagtggcaa ataaagaatt aaagaggggc 208561 ctgggcgcgc gccatattca gatgatcgcc ttgggcggta caatcggtgt tggcttgttt 208621 atgggttctg ccagcacgat ttcatggact ggcccatctg tccttctggc ttatgcaata 208681 tgcggaattt ttatcttttt tattatgcgt gcgatgggtg aaatgctgta tgtcgagccg 208741 agcacaggtt cttttgcgac gttcggccat caatatattc atccgatggc aggttatata 208801 acagcatgga gcaactggtt ccagtggatt atcgtcggca tgtcagaaat tatcgctgtc 208861 ggttcttata cgaagtattg gttcccggat ttgcctgctt ggatacctgg tatcgtggca 208921 atggtgattc ttggtgcggc gaatttaatt tctgttaagt cgtttgggga atttgagttt 208981 tggtttgcga tgattaaaat cgtgacgatt atcttgatga ttattgcggg aatcggaatt 209041 attttcttcg gttttggcaa tggcggagat gcgatcggtt tgtcgaacct gtggtctcac 209101 gggggcttct ttgcaggagg tttctcaggt ttcttctttg cactgtctct tgtcattgca 209161 gcctatcaag gagttgagct gatcgggatt acagcgggtg aagcgaagga cccgcaaaac 209221 acgctaagaa atgcgattca aagtattatc tggcgtattt tgattttcta cattggcgct 209281 atttttgtga tcgtgacggt gtatccttgg gatgagctca actcactcgg aagtccgttt 209341 gtgtctacgt tctcgaaaat tggaattacg gcagcggccg gcattattaa ctttgtcgtg 209401 attactgcgg caatgtccgg ctgtaacagc ggtattttca gcgcgggccg catgctgtat 209461 acactgggtg tcaatggaca agcaccgaaa ttctttaaga agatttcacg caatggtgtg 209521 ccgctgtatg gcacaattgc ggtgctgatc ggtttggctg tcggcgttgt actgaactat 209581 atcgcgccgc cgaagatctt tgtctatgta tacagcgcaa gcgtgctccc agggatgatt 209641 ccttggttta tcattttgat cagccatatc ggattcagaa aagcgaaggg tgctgcatta 209701 gataaacatc cattcaaaat gccgtttgct ccttttacaa actatttgac gattgctttc 209761 ttgctgatgg ttctggttgg catgtggttt aacgatgata ctcgtatctc cctgattgta 209821 ggcgtgattt tcttagcgct tgtggtcatt agttattatg tgtttgggat tggcaaacgc 209881 acgcaggcca atttgacaaa aagcgaacaa gcagctgaat aacgataaaa aagagacatt 209941 cacggatgtc tcttttttta tttttcgcgt atggattttc cctattttag caagctatag 210001 ggtaaagata gcagaaggaa aggtgttcat aaaatggatg ttacactcgg ttatttgcgc 210061 gaatcacttt cgaatcatct agaaaatgaa gtctgccagc gtatttgcaa gaagatgctg 210121 gcgaagcgtt atgcaaatga agaggaattt gtaaaagact tagatgataa tgaaatgtct 210181 tttttgaacc atgtattaga aaaagaaatt aagtatgccc agaatgaaca ggatcaaaaa 210241 cgggccaagg aattaaacga ggtgtatgaa ttactgcttt gagaaaggcg ggtaagaaat 210301 gggagcaatt gaacgaagcg gatatacatt tcagccggag tttagcgttg tccgtcaaaa 210361 cggagccatc catgtgtacc atcaaggaga atttgtggaa gaaatcgaat ttgaatttaa 210421 cggggaatat cccgatcatg atttgattga agagcttgtg aatcattatt gttttgagca 210481 tgagatttag agccctgccg tgcagggctc ttttatttag gatgtaatca ggccatactt 210541 tttcaggata tccacggtga tgtttttggc ttttgtgccg gaatcatcga cattggtgac 210601 aaagacataa gagccatgct ctgttttgat gaatccgaca aaccatccta atcccatatc 210661 agtcaggcgg gttccggttt tcccgtagag cgtgtaatga tcgccttcct cttgaatcat 210721 catgcgcttg acgattttca tcaccggctt gtcaaatgga agctcctctt tagccagttt 210781 ctccaaaaaa gtttcttgtt ccagcggaga tattgtgagc gagctttgca gccaaaactg 210841 gtcgattccc ccgctgatat cctcgttgcc gtaagataga gtatgaagcc atgttttcat 210901 tctttcctcg ccgatatctc tcgctaatgc ctgataatac cagattgcgg attcgcgcat 210961 ggccgagcca agcgtatggt cgcggttcca tgattcgaat tcacgcttga ccccgtccca 211021 tcgtttaaca tcgtattcat ctcttacagc tttgacctgc aaaccgatta aagcgttcac 211081 gactttaaag gtggattgcg gagtttgtct ttgatttgcc cgttttctgt tatagacaaa 211141 tgtctgatcc ttttgtaaat cgtgaagaat gaaggttcca tccgtatcct tgaattcatc 211201 atcgacattc attttgctga cattcaagtg tttttcatga gcagatgatg ctgcgtggac 211261 ggagaagccg ccgatccctg caatactcag cacaagcaca acatatatcc attttttcat 211321 tttgttctcc ccttcgtttt gattaactac cttttctctc tttcgtttgt tcttccttta 211381 aaaaataatc aaaaagcgct taaatttggt tttgcaaaca aatactgtta ctgggtttat 211441 agtcggaaga taacgtgaaa atagagggta aaaaggaagg cagggtaagc ggatgaatga 211501 gcagattcca catgacaaaa gtctcgataa cagtctgaca ctgctgaagg aagggtattt 211561 atttattaaa aacagaacag agcgctacaa ttcagatctg tttcaggccc gtttgttggg 211621 aaaaaacttt atttgcatga ctggcgctga ggcggcgaag gtgttttatg atacggatcg 211681 attccagcgg cagaacgctt tgcctaagcg ggtgcagaaa tcgctgtttg gtgttaatgc 211741 gattcaggga atggatggca gcgcgcatat ccatcggaag atgctttttc tgtcattgat 211801 gacaccgccg catcaaaaac gtttggctga gttgatgaca gaggagtgga aagcagcagt 211861 cacaagatgg gagaaggcag atgaggttgt gttatttgaa gaagcaaaag aaatcctgtg 211921 ccgggtagcg tgctattggg caggtgttcc gttgaaggaa acggaagtca aagagagagc 211981 ggatgacttc attgacatgg tcgacgcgtt cggtgctgtg ggaccgcggc attggaaagg 212041 aagaagagca aggccgcgtg cggaagagtg gattgaagtc atgattgaag atgctcgtgc 212101 cggcttgctg aaaacgactt ccggaacagc gctgcatgaa atggcttttc acacacaaga 212161 agatggaagc cagctggatt cccgcatggc agccattgag ctgattaatg tactgcggcc 212221 tattgtcgcc atttcttact ttctggtgtt ttcagctttg gcgcttcatg agcatccgaa 212281 gtataaggaa tggctgcggt ctggaaacag ccgggaaaga gaaatgtttg tgcaggaggt 212341 ccgcagatat tatccgttcg gcccgttttt aggggcgctt gtcaaaaaag attttgtatg 212401 gaataactgt gagtttaaga agggcacatc ggtgctgctt gatttatatg gaacgaacca 212461 cgaccctcgt ctatgggatc atcccgatga attccggccg gaacgatttg cggagcggga 212521 agaaaatctg tttgatatga ttcctcaagg cggggggcac gccgagaaag gccaccgctg 212581 tccaggggaa ggcattacaa ttgaagtcat gaaagcgagc ctggatttcc tcgtccatca 212641 gattgaatac gatgttccgg aacaatcact gcattacagt ctcgccagaa tgccatcatt 212701 gcctgaaagc ggcttcgtaa tgagcggaat cagacgaaaa agttaaatta aaaagctctc 212761 ttcctttatc gaagagagct ttttgattac ttcttttttt catcgtagta ttggacggga 212821 tacatggagc cttctgatac cattttgttg tcctcgatat cttgcgggtc cgggtggccg 212881 gctttatcaa ctgggaacgt ttccatgtct ggctgttttg ttattttcat cttcatgctg 212941 tgaatgaatt ctcttgcctt ttggcgattt gacgggtctt ttaatagata agaagtgatg 213001 ccgacagttg aaacagcgag acctgaaagt aacagctttt gtttcatggt gatactcctt 213061 tctattttaa gaatagtgtt tcctgtatca ttcccgtttt ggaaattgct aaacctgttg 213121 tgtttttatc attggaatta acagtaaatt ccatttaaga agaaactagt gacttcattc 213181 ctgtattgga aggtaatata cattgactta ttatagattt cagtcaaaat tcgataaata 213241 ttgacaaagt aaagtaatca gaataataat ataattagca agagaatgtc atcatacatg 213301 aaaggtgttt acgatatgaa tcaattgcat cgaagaatgg gaacgttttc cctcatgatg 213361 gtcgggctcg ggtcgatgat cggttcaggc tggctgttcg gggcttggcg tgcggctcaa 213421 atagcaggac cagctgctat tatttcatgg gttattggaa tggtcgtcat tttatttatt 213481 gctctttctt atagtgaact aggttctatg ttccctgaag cggggggaat ggtcaaatac 213541 acgcaatatt cacacggttc gtttatcggt tttattgcgg gctgggccaa ctggattgcg 213601 attgtgtccg tcattccggt tgaagcggtg gcctccgttc aatatatgag ttcttggcct 213661 tgggaatggg cgaaatggac aagcggtttg gtgaagaatg gaacgctgac tggggaagga 213721 ctagcgtttg cctctgtatt gcttctcatt tattttctgc tgaactactg gacagtcaat 213781 ctattttcga aagcgaattc attaattacg atttttaaaa ttattattcc gggtcttacg 213841 attggagctt tgctgtttgt cggattccac ggagaaaact ttactggcgg tcaaagcatt 213901 gcgccgaatg gctgggcaag tgtgctgacg gcggttgcca cttccggtat cgtttttgcg 213961 tttaatggtt tccaaagccc gattaatatg gcgggtgaag caaaaaatcc ggggaaatca 214021 atcccgattg cggttgttgg ctctcttttt gttgcgacag tgatttatgt cctgctgcag 214081 atcgccttca ttggagctgt gaatccttct gatattgctc acggctggag ccatctgaat 214141 tttaattctc cttttgctga tctggcgatt gcgctgaata ttaactggct tgttattgtg 214201 ttatatgcag atgcatttgt atcaccgtct ggaacgggga ttacgtatac ggcgacaacg 214261 tcccgaatga tttacggaat ggaaaaaaac aaatacatgc cgagtatatt cgggaagctt 214321 catccgattt acggcgttcc gcgacaagca atgttcttta acttgattgt ttcgttcatc 214381 tttttgttcc tgttcagagg atggggcgta ttagcggaaa ttatttctgt tgctacgtta 214441 atttcttata tcaccggccc gatcacagtg atgacattga gacggacggg gaaagacctg 214501 tacaggcctc ttcgtttaaa aggcttaaat gtgattgctc cgcttggatt tatctttgcg 214561 tcactggtgc tgtattgggc gcgctggccg ttaacaggac aggttctgtt tattatcctg 214621 atcggtcttc cgatttattt ctattatcag gcgaaggcga aatggaaagg gtttggccgg 214681 aactttaaag ccggcgtctg gatggtgttt tatctgctgg ccatgatggt tatttcttat 214741 ttgggcagtg ataaattcgg cggcctgaat gtcattcatt atggctggga tatggttctg 214801 attgcgatgg tatcccttgt attctatgtg tgggcgctga agagcggcta ccagacagaa 214861 tacttaaagg atgcgaaaga gataaattct cagctgctta atggacagtc agaagctgct 214921 gccggaaaag aataaaatat agaagaaaac cttgcgatag ttgtcgcaag gttttttgct 214981 tttaataacc cttttttact ttgtggaaaa gatcaggata gttggtgaac actcctgtta 215041 cgccccaatc aagcaggcga tgcatatcag cttcattatt gactgtgtaa ggatgaagca 215101 ggaggccgtg gctgcggatc atacggacgt tttcttgatt taaagcttta taatccgggc 215161 ccgcaccgac agcgtatgtt ttgatttctt ccagggcagc atctgtcatt gacgccattt 215221 gtttggcttc cagcaattga acggtcggca ggtttggctg taattgatgg acttttacca 215281 ggctttcttt gctgaacgat tgaatgatca cctggcctgg cttagaatgc tttcccagta 215341 atttatgttt ctgcaaagaa gcgatcagtt tttcttccat acctgggtag gtgtcaggcg 215401 attttgtttc aatgtagtag ttcgcgtgct ttccgaaacg gtctaatacc tcttctaatg 215461 taggaacttt aaggccgacg tactgcggct ttgctttttc cggataggct tcattaaacc 215521 aagaaccggc gtcaagcttc ttaatgtctg cgagcgtatg gtctttcacc caacccattc 215581 cgtttgtggt gcggtccagt ttttcgtcat gcatgacaat caattttccg tcttttgtca 215641 tttgcagatc caattcaata aaatcagctt tcattttctg agcggtttcg taagacagaa 215701 tcgtgtgctc aggcacatat ccagaagccc ctctgtgcgc gacggtcagg atacggtcag 215761 gtgacagcag gtttcctttt gacgctgccg acactggcgt taccataaat gagagtaagc 215821 ccagcgacag aacaaacaag gccagtattc tattttttct catgatttct cctccttata 215881 gataagcact acctgtcttt cataataaaa aacggatgta aacggcgtgt tggaaaacta 215941 ttaatctttt atgtgtcttt cttaaacatg ctctgcccgt tttcctgtat tccacgtcaa 216001 agccaagaag acgatggcaa gaatgcagga tgagatcagc atgataaagc cgccgttcca 216061 gttaaaacgg tccacgacaa agcccataat ggcgtttgcg aaggcggatc cgccgatgta 216121 tccgaaaaat ccggtcaaac cggctgcagt tccggctgct tttttcggtg ctaggtcaat 216181 tgcttgaagg ccgatcagca taacaggtcc gtagattaag aagccaatgc tgatcagggc 216241 gatattgtcc acgagcggat tgccggccgg attcagccag tacaccaata cggcaatgaa 216301 aacacccgcc ataaacaaaa cgcctgccgg tgcccggcgg cttttgaaga atcggtcact 216361 gatccagccg cacaagatcg ttcccggtat gcctgcgtat tcgtaaagaa aatacgacca 216421 gcgtgagtct tcaggagaaa agcctttggc ttctgttaag taagtaggcg cccagtcaac 216481 cacgccgtat cgcacgaaat aaacaaatac attggcaaaa gcgatgtacc aaagaaattt 216541 gttgttcagc acatattgaa aaagaatttc ttttgttgtt aattcttttt cctgattttt 216601 aaaagcgtgt tttggatagt cattccgata ctcttcaatt ggcgggagtc cgcaggattg 216661 aggcgtatca cgaaccaata aaacaattaa aaatgaaatg ataatggcga tgatggcagg 216721 gaagaaaaac acgcttttcc aagtgacgaa catcgcgatc ccaagagtga caagcggagc 216781 aagaataccg ccgcctatgt tatgggcgac attccagatc gacatttttg tgccgcgttc 216841 acttatggag aaccaatggg ccatcgtcct gccgcatggc ggccagccca ttccttgaaa 216901 ccatccgttg ataaacataa aaataaacat gatggtgacg ctcgaagtca cccaaggcat 216961 tgaaacgaat agaatattaa cgattgctga taaaaatagg cctgtcgcca gaaaatatct 217021 cggattacag cggtcagaca ccattcccat gatgaatttg ctgaagccgt acgcaatgga 217081 cacagcggcc agcaccaaac ccagttctgt tttcgaaaat ccctgttcct gcagataagg 217141 aatggcaaag gcaaagtttt tccgcagcag gtagtagcct gcgtagccaa tgaaaatacc 217201 aatgaatact tgcagtctga gccgtttgta tgccgcatcc atctttgaat catccagtct 217261 ctcaatatga ggagccggtt taaatatatt aagcattaat aattatcccc ctttgctgtt 217321 tgtgctggat gtgtggcgtg cctcctttcc cgaaaaacaa aaagagccag aaaacacccc 217381 ttgtcaaaag gggttggatt cctggctctc ctcatctcca tccaagctat taacttatca 217441 tgatagcgct ttcttaaatt atcatagtcc ggagcgaatg taaacgggta attttcaaat 217501 tgggccttag ggaagtgaat attatccttt tactaaatgc aattatattt ttttactagt 217561 aacataaaaa tctggaggga ggctgtttaa agatggatga attagatatc gcattcttta 217621 ttttaccgtt aggaattatg ctgctatcga ttgtcgggac ctgtatttgt aaaaacccgt 217681 atctgatgcc aatgcttagt ttggtgattt ctcttgtgct cacctttacc atttttaatc 217741 aatcattttt gggatgggct gttgtctata gcttggtttc tctggcttta tcctatatca 217801 cattgattgt ggtaaggaaa aggaaggaat caggaaatta aaaagacctc actttctaac 217861 atatcgttga ctaaagcaac tatatgtgat tataattgct ttagtcaacg atattagaaa 217921 gtgggaattg atttgaaaac aagagaatca tctgtcgggt taaaattcag aaagttcaat 217981 cgattttata caaacgtcct tggtttcctt aatgagcaca tttacgacag cccgttttcc 218041 ttaacagaaa cacggatttt atttgagatt tataatacgc ctaattgtac ggcaaaagct 218101 cttcaggata agctggggct tgaccgggga tatgtcagca ggattgtgaa gcagtttgaa 218161 aaagaagatt tgatttataa acagaggagc aaagatgacg cccgccacca ttacattttt 218221 gtcacagaaa caggaaaaac gatttataaa aagctggagg agaaagccaa cgaacaagta 218281 gaactgatgc tgaaggtaat caaccaaaag gagcagcaca agcttgccga ggcgatggca 218341 gagattgaag cgatcctttc acagtcgctt tctgccagag catcagagat atcgattaga 218401 gattattttc tttcggagga tcttcaactc cttattgaga aacaaagaca attttacgcg 218461 gaggctcacg gttgggatga cacgttttta gcttatcttc aggagacatt tgacgctgac 218521 atcgaaaaaa tatggattgc ggaaagcggc gggaaatttg ccggctctgt cgggttggtc 218581 aagcacgatg aaaagacagt ccagctcaga tggtttctgg ttgatgcgga ttttcggggc 218641 agggggcttg gcacgcaatt gctggagcat ctggttgcat actgccaaga catgaagttt 218701 gaccgcattt tcctttggac ggtgagcacg atggctgagg ctcgtccgct ctataaaaaa 218761 tttggattca ggataagtga agtaaaacaa gaagcgccat tatggggaca gcagctgaca 218821 gaagaacggt gggatttgga gctgtcatga aaagactgca ttatgcgtgg atcatcgtct 218881 ccgtcacctt tttgatctta ttggcggttc agggggtgcg gctgtcgttt ggtgcgtttg 218941 tggagccgtg ggaacggcag ttttcaatcg atagaagcac catctcgctg atttcgacgg 219001 tgagttttat tgtttatggc atatcacagc ctgtgatcgg tcggcttgtg gacaaatggg 219061 gtgcccgggc tgttttggca tggagtgcgt tactgacagg agtcagcatt ttcttaacat 219121 accttgtgac ttcgccttgg cagctgtttt tgctttacgg gctgggtgtc tcgcttggag 219181 tgggcggagc atcgaatgtg gcggcaagtg tattggtcgt caattggttc agcaaaaagc 219241 ggggactagc ctttgggatc atggaagcag gctttggcgc ggggcaaatg cttctcgttc 219301 ccggctcact catgttgatc cattggttta gctggaagct gacggttgtg gtgttgggac 219361 tgctgttaat cgtgattgtc tttccggctg cgctgctgat gctgcggaac aatccttcag 219421 aaaagaatac agagccgata ggcggactgg ctgcatcaga aaaagaaaca gcacccaaaa 219481 caacagctct ttcagtggcc gggatgtttc gtatgaggca attctggttc ttgatttttc 219541 cgtttttgat ctgtggattt acgaccgtgg ggctgatgga tacccatttg attccgtttt 219601 ctcatgatca tggcttttca acgacagtca cgagtgctgc tgtcagtctg ctagcaggct 219661 ttaatattgc tgggatcttg ctgtccggaa ttgtagcgga ccggtggagc agccggaaaa 219721 tcctgtgcat tttatatgcg gtgcgggcgc tgtcgatcgt gattcttatt tacagccacg 219781 agccctactt gcttttagcc tttgcgattc tgtttggatt agtggacttt gcaacggtag 219841 caccgactca aatgctcgcc acccagtact ttcaaaacta ctcgatcggc ctcatgattg 219901 gctggctgtc actcgcccat cagatcggat cggcactagg tgcgtatgtg cccggcgtca 219961 tctacacggt aacgggtgag tatacactgg ctttttattt gtcgattgga atgctcgtgc 220021 ttgcgagcgt aatgaatgtg atgctgaggg agccagctgc ggttacgcgt gacagtgcgg 220081 ctgtggtaga caagtgatga ggacaaaggg aaagcatctc tgatttcgag attattcaga 220141 gatgcttttt ttgtattttt gttctaatac gaagtcgatc ataccgacta tgcgggcgtt 220201 ttcggatttt tgtttgaagc gttcagaaat ttgaactttt cttgaaaatg gggaaacaat 220261 aaaaacccaa aaaaggccga tcaaggcaaa aaacatttgt acagctaatt ctattaattc 220321 attaaaacga gtgctgaaaa aatagaagta taacgttatt aatgtcacag tacatacgat 220381 tttggcaagt gtgtttgaat gtaagcaatg gttcactaaa gaataccttt aattgattca 220441 gcatgattga atcatatttg tttaggaaaa taagaagttc tttatcatct tttttatgtt 220501 ctaaaataaa gttgctgttt ctgtttcttt atatgtatgg tggtctacat tcaatatata 220561 catctcttaa agtataaaaa ttgagtattt cttagtaagg atgaaacaaa attacatgat 220621 ttttttgtta tatctttcag ttagaataaa atctataact cctctcattc gcaaatattc 220681 ggctctctgt gcaaagtgca gaacagtatg taattgtcct tttctagata tatttaaaag 220741 ctttatcaaa tcaataagga ttttcaagaa aataattaat aatagaaaga taaaaatgtg 220801 tggtatgtca atgtaattga tttgtcctga aaataaagaa gttgcataga caacaataat 220861 acttccgcaa aacatcaaac tcatataatg tggaagggaa aatggacgag ttgaaaaata 220921 tgcttttaat tggcttagca tagcattatc tcttgtatct aagtagccca aaagctcttt 220981 atcattttta ctaattgtaa gaacatgatt caatacagca ctaaaattca ttgaatcttc 221041 attatcagag gcagtatgtt tattagcctg tatgttttgt tgatccattt tatatttttt 221101 ataaagtatt gtattaatta acttgttttt ctcatagaat tcagatcgtt gattaaggga 221161 tgcttttcct ttgtttttat ttcctttttt tatgatttta gtataagtca taaaaataca 221221 aatgactgta aaaatagaaa acactgcagg tgaaatatct gaaagaatag tattggtgaa 221281 gacttctttt gcttggatga aaaggaaaga agctaaagtc atagatataa acatgcataa 221341 aactgctact ttcacaagaa actgaagcgg aagagaaggt tccgaataat agtgcttcaa 221401 ctggttgagt gtcagagaat cttggcgaaa aagataatct attatctcct gctgattttg 221461 catctgattg atatcatgag cgatgttttt tgttttttca aaaactattt gatcattttt 221521 catttttgat aaacctccaa aagacgatag ataaactaaa aaaactgcat gagcatattt 221581 taacttatgt tcatgcagtt ttgtattaaa gttagctagt ataataagca aaaatggcca 221641 gtaacatagc agataatgcg gtagcgactt tgactccttt attgttcgtt aaatcactgc 221701 ccatattccc aattagtaaa agtgcagcaa cacctacaac agggaataaa tattgatcat 221761 aagacggcca atctaacgct aattcactct cgggagacgt aactggtact cccttgtacg 221821 tctttatttt aaacgtaatc gtagtcgtta gtccagttgt gacattgtca ccgactggaa 221881 tatcaggtgt atagatttta atttgaatgt ttaaagattc agctgttgga tttacataaa 221941 cctccaaata accgttgcgt actgataagc tcagactatt taaaaggttt tgataagagt 222001 cgatttgtga cgcagtgaga gacgtttgag tgtcgcccaa taaacccgtg atataggcac 222061 ctggtttacc atttgtaatg gtaattgtgt ttggtgaacc ttcacttggt atggttgcca 222121 gaagtgaagt tgatagaata atatccaact caggtgatgt gaaaatggtt tctgtcgtat 222181 caaattcaaa catcgcgttt gccagacttg ttagattttc taaagctgga atggtagata 222241 aaatgtctgt cagtgtacgc agtcttgcat catataccgg atcagacggc ggatttacat 222301 tgcttgcacc tgagtctctt cctgaatacc cgtctttatc aatcccgatg cttccagagc 222361 cgcttccgat ggttccttca taaaattgat caaaggccca gttgtttggc atcggatagc 222421 cgagattgcc gctaaatcct gttgacatat ttgccacaaa actatacttt gtcagtcctg 222481 cttcagatgt acggatacaa atgtttcttg gtccgtaaac ccctatttca tacttaggtg 222541 cggttgaaaa tgtctgcatt tttgtaaatg ctgacttaat ctcttggaaa taaggaatga 222601 ttttatcggt cacttcataa tcgtatgcat caaaatcgac agcgaaataa atggtcgtgc 222661 ctgacggaaa acctaatctt ctagcagcag aagcggcact atatgcatct cttgtgcctt 222721 ggtctttgac aaaataagaa gattcatagc cgccgtcttg ataaattggg aaaaccttca 222781 atccggcatc aagaataact gcaagctctt tagatgtcag ggctttagat gtgaggccgc 222841 tgcttgtccg cacatttccg gtcaaatatc tgccaaccgt tttataaccg ttattccgca 222901 gtgtttgagc tttttctgcg gttataattg tagcagtgtc acaagcagaa gcggtgcgag 222961 ttgtgtctcc tgagcttgat aataaagctt taatggttgg catatctgca taacctgttt 223021 gcggcaggca catgaactct tgaaatgctt taacagctga aacaacaccc acaccatatt 223081 tgccgtcaaa ctcaccagga tcgaacgatt ttccgttaca atagagggcg tactgaacaa 223141 ttaagacaaa tcctgttctt gaatcgccgg gagttaaagt agggcacaaa cttgtggtgc 223201 cgtttccgaa aaatccattg gcaacacttg tgctcatgcc ttcttctttt tgcagggcat 223261 aaataagagc tttatttgta tcgcggccat acagtccgtc acaaggcatt aacccgatat 223321 agtcattgta gtctcgattt aagttttgtt gaatctggcg aattcttgaa tcacccccag 223381 acaccagctt aaaagcgctc atgtctaata aggctttcat aattaacgtg gtgacaatcc 223441 catcctgtgt tgtcagtccg gcagcttttt gaaattcttt taccgcattt tctgtttttt 223501 cgtaaaagac gcctgtaaaa ccgccgggat taaagccttt acaccataaa gccccttgta 223561 aaataaaatt catgttgctt ggttttgaat ctggagcttg gcgtttaaga ggcttaaata 223621 agcgctgtgt tgtcggcccg aagttatcgg ctggctctga gatacccaat tcaatttgaa 223681 gcgcccgagt cagaccgtag atcgtatccc acccagtttt cccgctttct tcaactgggt 223741 tatacccatg tttgccgctg tacgtatcgt tcagccattg ctgtgtgatt aagaccattt 223801 catcaaccat ttcgattcct cctttgttag attgcgttca tttataggtg gcaaacgtag 223861 gacaaaataa aaaaatggat gccgttaagc atccatttta catccgttct ccaacagctt 223921 cgctttcggt ttcagctctg aaatgtagag gcctaaaagt gtaagcgcgc ctcctagaag 223981 agcgatccat gtcatgtttt cgtgcagaat caggacagaa gcggcgatcg tgataaccgg 224041 gaccatgtaa atatacgcac tggatttgac ggctccgagc actccaactg aataattcca 224101 agtggcgaag cacagggcag aagcgccaat ccctaagaaa agcatgttga gtatatttga 224161 agcagatgaa aatcggctta ggtcaaaatg gaagtcgaac aaaaataaag cgggaaccat 224221 aaacaataaa ccatacaaaa atactctctg tgtcagctcg atgatgtggt attcgtaggc 224281 gcttaatttt ttcatgaata tcgagtatcc gccaaacacg agagcagccc cggctgccat 224341 gatgtctccg agcggattta gacgcagtac cacattgccg ttaaacgtaa tcaataaaag 224401 cccgatcagt gccgagataa atccaatcaa aaaagtcaga cgcaattttt cgccttcgag 224461 cagaaaatgg gccaaaaccg cagtgatcat cggtataatg gacacgatca tgccgacatt 224521 ggaggcgtat gtataggtga gagctatatt ttctaataga aagtataagg ttacgccaaa 224581 taaaccagct ccggcaaaca acagctcctg ccgccaattt ctgaacggaa tcatgttggg 224641 acggacgagg ataagagcga taaagcccat caaaaaccga taaaataata tttccattgg 224701 agagaagtca gccagcagaa cttttgtcga aataaaggtc gtcccccaaa tcagaatggt 224761 cacaatggct gcgatatgcc ccgaagtttc tctttgtatg ttcatctgtg aagctccttt 224821 tcaaaaatct tcatgtattg cttcggcgtc agccccacct gccgtttaaa aaacttcgtc 224881 atatgactct gatcgctgaa tcctgtctga aatgccgcat caatcggcct taccccttgt 224941 tcaaggagtt ttttggcttg attaatccgg attgtttcca tgtagctatt aggggtaatg 225001 cctttttgtt ttgtaaatga acgcaataaa tgatacttgc tccagcctgt taattcactc 225061 aaatcattga gtgtaacatt ttcggcataa tgctcttcta aaaattcaca aaccattttg 225121 acttcgtctg atggttctgg aacgctgcta aggaacgtga catctgaata atggcggatc 225181 agctcctcta atagatgaag aaacagctcc tccttacgca aagcttgttt ttcctcggat 225241 atcaaaatat gcaattcctg caggctggct gtcagctcat ggcggaataa cacatgctgg 225301 gagaaataag ggagatgccc ggagccagta atctctttca ccgccttctc catgatatcc 225361 ggcatgacat tgatacaccg ataatcaagc gtccggccgt caatctgttc acagctatgc 225421 gtgtcacggg ggttaaagag gagaagatca cctggattga tgatatattc ttgatcctga 225481 caggccagat accgttgccc tttttcaata aatccaatca cataataatc gtgaaagtgg 225541 ttcgggaact tctgcataat tcccttgaag cggtaggctt ctatatgaag gtgtgggtca 225601 agctgcagtg tgcgggtttc gttttgcatg ggatgcctcc tgtcggtgtg gtggtcttgg 225661 attaagtgta gcatgatttt gggggatttc ttgtatgatg ttgctgttta ggaatagaga 225721 aagcagaccg ttatttgtct gctttcgttt aagaatttaa aagattttaa ccctcaataa 225781 taattttatc ttttttaata aaaatttatt tttcaaatat ttcagttata atggtttgga 225841 acagatagga ggggcaaaga tgtatcaatc aaagaaggtt ttattgttag gttcaggtga 225901 attaggtaaa gaggtagtga ttgaagccca gcgtcttggg gtacagacgg tggcagttga 225961 cagttacgag catgctccgg cgatgcaggt cgcgcataac agttatgtcg ttgatatgct 226021 ggacccagag cagatcagaa ccatcattga gaaagaaaat ccggatttga ttgtgcctga 226081 ggttgaggcg attgcgacgg atgaattgct gaagcttgaa gaggaaggat ttcacgttat 226141 cccgaatgcc cgtgcggcca agctgacgat ggatcgggaa ggcatcagac gacttgcggc 226201 ggaaacgctt ggacttgcga cagctggcta tgaatttgcg aatacatatg atgaatttat 226261 acaagcggca gctcagatcg gttttccttg tgtcgttaaa ccattgatga gttcttctgg 226321 aaaaggccaa agtgtgtgcc gctctgaagc ggatttagag agctgctggg agacggcgat 226381 ggaaggcgga cgggtgaaaa acggccgcgt gatcgttgag gagtttatcc ctttcgaatc 226441 agaaatcaca ctcttaaccg tacgtgcggt taacggtacg gcattttgtg agccgatcgg 226501 tcatgtgcaa aaggacgggg attatatcga atcgtggcag ccgcatgata tgacagagca 226561 gcaaatagaa gaagcgaagc atattgcgaa aacgatcacg gatgagcttg gcggatacgg 226621 cctgtttggt gttgagctgt tccttgcgaa agatagggta tatttcagtg aggtatctcc 226681 tcgtccgcat gatacgggtc ttgtcacgct ggtgacgcaa aatttgtcag aatttgcgct 226741 gcatgtccgg gcgattctcg gctttccgat tacagaaatc acacagcttt ctcctggcgc 226801 cagcaggccc ctcaaagcgc cggaagaatt agcggattac actgttgaag gattggaaaa 226861 cgcactggca gtcccaaaga ctcaagtgcg cgtctttgga aagccgataa caaaagccgg 226921 acgtcgtatg gcagttgcgc tttctgctgc tgattcagtt gaaacggcaa gagagaatgc 226981 aaagaaagcg ttggaccagc taattttaaa atagagtttg aacaggtctt gtcatgggac 227041 aaggcctgtt tttttctttc tccgtaaaag ttttatcata agaatcagaa acctgattat 227101 aatgtaaaag tcttccatcg atacgggtgg ttgacactaa aggagggaga tgacaaaatg 227161 aaattagttc caagattcag aaaacaatgg ttcgcttact taacggtttt gtgtttggct 227221 ttggcagcag cggtttcttt tggcgtaccg gcaaaagcgg cagagaaccc gcaaacttct 227281 gtatcgaata ccggtaaaga agctgatgct acgaaaaacc aaacgtcaaa agcagatcag 227341 gtttccgccc cttatgaggg aaccggaaaa acaagtaaat cgttatacgg cggccaaacg 227401 gaactggaaa aaaacattca aaccttacag ccttcgagca ttatcggaac tgatgaacgc 227461 accagaatct ccagcacgac atcttttcca tatagagcaa ccgttcaact gtcaatcaag 227521 tatcccaaca cttcaagcac ttatggatgt accggatttt tagtcaatcc aaatacagtc 227581 gtcacggctg gacattgtgt gtacagccag gatcatggat gggcttcgac gataaccgcc 227641 gcgccgggcc gcaatggttc gtcatatccg tacggtactt attcaggcac gatgttttac 227701 tccgtcaaag gatggacgga aagcaaagac accaactatg attacggagc tattaaatta 227761 aacggttctc ctggaaacac ggttggctgg tacggctacc ggactacaaa cagcagcagt 227821 cccgtgggcc tttcctcgtc agtgacagga ttcccatgtg acaaaacctt tggcacgatg 227881 tggtctgata caaagccgat tcgctccgct gaaacgtata agctgaccta tacaaccgat 227941 acgtacggct gccaaagcgg ctcgcctgtt tatcgaaact acagtgatac agggcagaca 228001 gctattgcca ttcacacgaa cggaggatcg tcatataact tgggaacaag ggtgacgaac 228061 gatgtattca acaatattca atattgggca aatcaataaa tacagcaaac tagccatatt 228121 catgtctatt ttgtttttat gcgggtgcag ttcgcagacg cattcttctc aaaaagaaac 228181 gactattcct gtcactcttc atgtggagga tgctaagggg ctgccggtcg aaggggttca 228241 agtgacgatt gtcaaagcgc cctcttcaga tgaggagccg agtacagaga ttggcgagat 228301 actcggtaaa acagacaaaa acggagatat caaatgggat accggcagaa aaggcgatta 228361 ctcagtcgcg ttgacgaagg gtgaaacatc agtaacccat cacatctcgt taacagagga 228421 taaaaaagat catgccattc cattagtctt caaagaatag cagtttcctt gattttaagg 228481 gaactgcctt ttttatttat tgcaggaaac caaactatat actggaaatt tattatgtga 228541 gataataaga aataggtatt ttttcttacg agacaaaagg ggcgttatcc tttatatcaa 228601 tcaaacccgg aggaaaaaga agaagatgat acaagattca atgcagtttg ccgcggttga 228661 aagtggtctg cgcttttacc aggcatatga tcaaagcctt tctttgtggc cgattgagtc 228721 ggaagcattc tatgtttcta ctcgttttgg aaaaacacat atcattgcaa gtgggccaaa 228781 ggacgcacct tcgctcattt tgcttcacgg aggccttttc agctctgcga tgtggtatcc 228841 gaatatcgca gcgtggagca gtcaatttcg tacatatgcg gtcgatataa taggagacaa 228901 aaataaaagt ataccatcag cagccatgga aacgagagct gattttgcag aatggatgaa 228961 agatgtcttt gattctcttg gacttgagac ggcacatctg gccggccttt cgcttggcgg 229021 gtcccatatc gtgaatttct tactccgcgc gcctgaaaga gtagagcggg cggttgttat 229081 cagtcccgct gaagcgttta tttcatttca tccggatgtc tataaatacg ctgcagagct 229141 tacaggggca agaggagctg aatcatatat caagtggatc acaggcgaca gttatgatct 229201 gcatccttta ctgcaaagac aaattgtggc gggcgtggaa tggcaggatg agcaaaggag 229261 cctgaagccg acagaaaacg gctttccgta cgtgttcaca gaccaggaat tgaaatcaat 229321 acaagtcccg gtacttctga tgttcggtga gcacgaggct atgtaccatc agcaaatggc 229381 ctttgagcgg gcttcggtat tggtgccggg aattcaggct gaaatcgtaa agaacgccgg 229441 acatctgtta tctctggagc agccagagta cgtcaatcaa cgcgtcttgt cctttttatg 229501 cggggggata aaatagtaag gaacatgaaa agattggcat tcatttttca aaaggtaaca 229561 aatgttgtat aataatagaa tttgaatgct gctttttttg ggagcattct atgttatcat 229621 gcttattgga gaaaaatttt tcctgtaacg ctattcgatc actatcgtca aataatatag 229681 atggttttac aattggaggt ttggttacac tgtgaattac atcccctgta tgattacgat 229741 aggaaacttc atttgcggat tgctggcgat tcattccttg ctatatcaca acattcattc 229801 agcagtgctt tttattttta caggcatgtt ccttgatttc tttgacggga tggctgctcg 229861 taagctgaat gccgtttctg atatggggag agaactggat tcgtttgccg atctggttac 229921 gtttggggtg gctccttcta tgcttgctta cagtgtcgcg ttgtataccc tgccatttat 229981 cgggatctta tgcgcattga cgtacagcat ttgcggaatg cttcgcctct ctaaatttaa 230041 cattgaacaa agcaagctcc cgacgtttat cggtatgccg attccgtttg cgggcatgtg 230101 tctcgttatt ctaagcttca cctataaccc gatccttctg gcaatcggca cttgcggact 230161 ctcatatttg atggtgagta aaataaaatt ccctcatttt aaaaaacatg cggcagaaaa 230221 cctggagtct gggagatgga attagttcag cagctcatag cggattacgg ttatctcgct 230281 atttttttga tgctggtatt aggaattgta ggattgccga ttccagatga agtgatgatg 230341 accgttgttg gctatttcac gcataccgat gtattgaatt atgagctttc gatattgatt 230401 agttttgtcg gggctttgtt aggtatgctg atcagctaca tgattggcag aaaagccgga 230461 cgcccgttta tcgacaagta cggcaagtgg gtcggcttaa aagaaaaaag aatgatgaaa 230521 gtggaaaaat ggatgaagaa atacggtcca tattctctta ttttaggtta ttttattccc 230581 ggcgtcagac atgtgacgtg ctacttttcg gggatcggca aaatggatct gaaaacgtat 230641 gttgcgtttg ctgcaatcgg cgccttttta tggtgctttg tttttattac aatcggaagg 230701 gttataggga ttattcatgt ttaatacggc tgtaaagatt ctgtatcgat cattgataga 230761 gctgacgaat catcgtctgt catcctatct gattaaagga ttttgcgagt cgaaaatcag 230821 caaaccggtc attccgcttt tctcaaaaca ttttcggctg aattgggatg atgtggacgg 230881 tacggctgct gattacggat cgctgtccga attgttcatt cgacaaataa atctggagcg 230941 gcgccctgtg tcaaaagagg cgcatgcggt ggtcagccct gttgacggtg tggttcagac 231001 ggtaggaatc atcaacccga atcaaacctt tacggtgaag ggaaaagatt actcattcgc 231061 tgagctgacc ggctgtaaaa gcgcagacca tcaatacaac ggcggatatt tcgtcgtgct 231121 gtatttaagc ccgaggcatt atcaccgttt ccattctccg atcagctgca ggtatcaaaa 231181 gctggccgag ctcggaaatc gctcataccc ggtaaatcaa ctaggcttaa aatacgggaa 231241 agatgtgctg tcgaaaaatt atcggtttgt gtacgagctg aatagcggca gccgaaatgt 231301 cctgatgatt cctgtcggcg cgatgaatat taattctatc gtgcagacga atacccgtac 231361 tgaattggag atcggcgagg agctgggata cttttcattt ggctcaaccg tcattttggt 231421 ttttgaaaaa gacgcgttcc agccgtccgc ccatttagca gaaggccaag aagtccaagt 231481 cggagaactg ataggttacg aagaataaaa agaggagctt gcataaacgc agcgcctctt 231541 tttttgaaga aaggtgagat tcatggagaa acaaatcatc agctggatta cagattatca 231601 gaacaccgga gatgaagccg tcctgcggca agtgcgagaa gtgtgctggc cgatcgttga 231661 agcggttttg caagagaaag taatggatga tgaacaagcg aacaatttgc gcgaaaaagg 231721 aatcgagcgg tttccattca tcatcagcaa ataccaagcg gatgtgcagc ttccggttga 231781 gacattttta caaaatacgt atcggtttta ctttcatcag gtgatgagag aatccagcta 231841 aagcttcttt caacagagaa gctttttttt gttggcagga aaaggaaact ttttctatat 231901 ctatctcgta atgactagag aacctagcag aaaaggagag atagaattga aacgaatgat 231961 agtgagaatg accctgccgc tgctgatcgt ttgtctggcg ttttcttctt tttcagcctc 232021 agcccgtgct gcttctgaag aaaaatattg ggatcactgg attgaacgac atgcacagcc 232081 tctggatgct tccaatgctt caaacaaaga ccttcgattt ctaaaaaagg tgctgaaggg 232141 aaaacgaatc gttcagttag gagaaaccac acacggtgct ggcgaaatca atgccacaaa 232201 ggtcagaatg atcaaatacc tccacgaaga gctgggatac gatgtattgg cctttgaatc 232261 cggctttcct gatacaaatg catcctacct taatatggac caattaaccc ctaaaagcac 232321 gatgaaaaac tccatttacg ctgtatggca cacagaagat gtcgtcgaat tgtttgatta 232381 catgaaagag caaaaagaga aaggcgatcc gctgatcctt accggttttg atattcaaag 232441 catgaagaat tcattcaatg tagctgcgac tcaatgggta aaagcggtgg accctgagaa 232501 agcagagttg ctctcccaat cagaaaatga tttttcaaca ttagtgacag acagcaatac 232561 gtttgatgaa ttttcgcaaa agaaggaaaa gcttgtgaaa aactatcaga agctgatcaa 232621 gttcactaaa acacatgctt cagagctaaa agaaaacctt ccaaaagagc cgaaagctta 232681 tgagatgttt atgcattctc ttcagctgag aattgacgta atggaaacat atatgctgga 232741 agaaatgaaa gaaaaactag aggagtatcc ggagaatatt gaggattttt cattctttat 232801 gagagaccgc atgatggctg aacaatttca gtgggtagcc gacacccttt atccgaaaaa 232861 gaaaatcatt gtctggggcc acaattacca tctacgcaaa cagaatacga agatgataaa 232921 ggactgggta cagctaaacg gccctaacat gggtgattat ttgccggagc ggctgaaaaa 232981 acaaacatat acgattggca tttatgctta ctcaggtgcg agtcttgata gctccgataa 233041 taagactgtt aagccggtta caagcccgcc gccgtctggg agccttgaag ctttgctgaa 233101 agcggcggac cgaccggctg tttttgttga ttttctccat acaaaaaaca agaaaggcac 233161 ttcgtggatg tataccccgc ggactgcgct ctattggggg tacatggaag agcagatgat 233221 cctgaaggaa caatatgacg gtgtcatttg gctggagcat atcacgccct ctgtcattat 233281 caagtgagcg gtgtcccctg tggtaaacag gggattttta catatcgcaa aaataatcaa 233341 aacatataat ccgtgatcca ttattctaaa acagaaagga gattggagcg tgcaatgtat 233401 tatgaaaaag ctgtccagaa aacaatcaat tggattgaat cacatttaca tgagcaaata 233461 tcaaacgagg atattgttaa cgtttcaagc ttttcaaaat tccattttca tcggattttt 233521 caaaaagaag tcggcatgtc ggttgcttct tatattcggt taagacgtct tgcgaatgcg 233581 gcggcagctt tgctttatac agatcatcgt attatcgata ttgctttgta ttatcagttt 233641 gaatctcaag aagcatttac gaggacgttc aaaaagatgt atcacatgcc gccaggagca 233701 taccgaacat ttatgaaacg ctttacttca aaaaaggagg aatcttacat ggagaaaaaa 233761 atgaaaggct gggtattgag cgggagccat ccgttccaat tcgaaatggg gattgaccgg 233821 gaaaatgtac atcagggaaa agcttcaggg tatttaaagt caacgatggt tcaggatatc 233881 ggtgaatttg cgacgatgat gcagcaattc aaagcagatc gctatctagg aaaaaggctt 233941 cgtctatcaa gttttatcaa aacaaagggg gtgcagcatt ttgcctcact ttggatgcgg 234001 gttgacagtg ctgctgatga tgttctccaa tttgataata tgagcaacag acctattacc 234061 ggaacaacca attggaatca ttatgctatc gttttagatg tcccagaaaa tagcgctgtg 234121 atatcttttg gcgttcaatt atctgggccg ggtcaggtgt ggatggatca tgttgttttt 234181 gaagaggtag atgagagcgt tccttcaaca aaccttgaaa tgccgggaga acttttagat 234241 gaaccggtaa atttatcttt tgaagaggaa ctacaaaaat agttttcaga caactacttt 234301 tattagtgag ttaatggaaa atactatttg ttattaataa acccttgtgc tgcttaggtt 234361 tgtaagagct tggatatttt tatcagtctg ggcggatctg ttcatctttg cggcattttc 234421 ctgtatgata tagtaagagt gtgcatagca actaactata attgaacagg gtgtttaaaa 234481 catggaaaaa caatacagag tattacttta ctataaatat gttccgattg aagatccaga 234541 ggcgtttaga gagcagcatc tggctttttg taaggagctt ggtttgttag gccgtatcct 234601 tgtttcttct gaaggaatta acggtacggt atcaggtacg gttgaacaga ctgaaaaata 234661 tatggaaaca atgaaagctg atcctcgctt tgcggacatg gtatttaaaa ttgatgaagc 234721 agaaggccat gccttcaaaa aaatcttcgt ccgccataaa aaagagcttg taacgcttcg 234781 tcttgaagat gatgtcgatc cgaacgaaac aacaggccag catttgaagc ctgcagaatt 234841 ttatgagaag atgcaggatc caaacacaat tgtcatcgac gcgcgtaacg attacgagta 234901 tgaccttggc catttcagag gtgcggtccg tcctgacatc gaagccttcc gtgaattacc 234961 tgaatggatt gaagagcaca aagatatgct tgaaggcaaa aagattttaa cgtactgtac 235021 aggcggcgtg cgctgtgaaa agttctcagg atggctggtg aagcaaggct ttgaagatgt 235081 agctcagctt gatggcggaa tcgtgacata cggaaaagat ccagaggtgc aaggcaagct 235141 ttgggacggc cagtgctacg tatttgatga aagaatcagc gtgcctgtca accgtgtcga 235201 gcatgtgatt gtcggcaagg actactttac aggagaaccg tgtgagcgtt atgtgaactg 235261 cgcaaatcca tcttgcaata aaaaaatgat atgcacaccg gaaaatgagt ataaatatat 235321 gcgcagctgc agccacgaat gccgcacgaa cccaagaaac ctgtatgtga aagagcataa 235381 tatgacagaa gaagaagtaa acgcaagact ggcagcgatt gaaacagaag atcacgctgc 235441 tgctgaataa aaaaagaaca cctcgtattg aggtgttctt tttttctata tgctttcagt 235501 ttggctgttt gcggaaaccc attctttttg gcggaaggcc ttttcccatt ttgataccac 235561 gatacaggcg atcgcatgtc ccggtacgtt cacgcctgtt ctcgccatgt ccatgacgcg 235621 gtcaacaccc gcgataatgg caacgccttc agccggcagt cctacagcat tggcagtcgc 235681 cagaagaact acaagcgatc ctgagggtac agctgcaatg cctttactgg tcatcacaag 235741 cacaagcatc atgagcagct gctgggacaa tgtcatgtct acttgaaagg cctgtgcgag 235801 aaagatacaa gaaaccgata aatataagct ggagccgtca cagttcaatg acaagccgga 235861 gggaacgaca aatgatacca ctcgtttggg acagccgtat ttctccattc tatccatcag 235921 ctgagggaga atggtttcag tgcttgtggt ggaaaatgca attaaaaaca gatcccatat 235981 cattttcaat acttcgaaat acttaatctg aaagatgaga ccgacaagcg gaaagaggac 236041 aaagaggatc aggaacaggc caaggaatac ggtgccaacc agcttaaaca tagggaggag 236101 gagttcaatg ccatattggc ctacagaagc agccatcagg gctaacacgc cgataggagc 236161 agtgaccatg acgatttgcg tgagcttgaa cataatctga gctgtagatt caaaaaactt 236221 cattactggt tcagaagctt tgccgatacc agctgcggcg acaccaaata aaatggcgaa 236281 gaaaataacg gcaagcaaat catttctggc catgacatca ataatgtttg tagggataat 236341 atccaggatc atttgcttga aatcaacaac tttgtctgtg tagccggaaa gttcatgaat 236401 atcttttttt gccaaatggg agaggtcaag cccgacacct ggttttaaga cattcgctaa 236461 taaaagtcca agccctaata ccaacgttgt aatcacttcg aaccaaatga tcgtcttgat 236521 gccgagactg cccatttttt tcatgcttcc gcttcctgcg gctccaatga caatggtaga 236581 aaatacaatc ggcacaacaa tcattttaat caggcggata aatccatctc cgacaggcct 236641 cagtgccatc ccgaaatcag gaaaaaagtg gccgatcacc gcgccgacag ccaaagcgat 236701 taaaatttga aacgcgatta attttttcaa atgaatcccc ctttagaacg atagaatgta 236761 ggcatattca tatcattcgt gattcaaatg caaacacctt ttttcaagtt attttatttt 236821 gacagcgctt tcattatgtt ggcgaaaaag tcccccgcag caggggggac ttttttactt 236881 catttgaatg tgctttagat cttcttcaga ggtatttgtg aaaataaccg gtgttatggc 236941 tgaagcggca tgctgcttga tgtaattgag atcaaaggtg agaagcagtt cgccttgttt 237001 gacggcttgt ccgcttgtga catgtgcttc aaagccttcc ccattcagtt tgacggtatc 237061 gatgccgaca tgaatcagga tttcagtgcc gccggcgctc ataaagccga tggcgtgttt 237121 tgtcggaaaa atcgagacga tctcgccgtc cgcaggtgca acgacttttc cttctgatgg 237181 tataatcgca aatccctcgc ccatcatttt ttctgaaaag acctgatcag gcacatcccc 237241 taaagagact gtttctcctt taatcggata aataaaggtc tcatcggaat cgggcttcag 237301 cggtttgtca gttaccgtgt ccagcgcggc ggcggtggca gggacgcctc cggccatgat 237361 tgttttgatg tcgtctttta aggcatcgga cttggttccg aatattgcct ggaagttgtt 237421 gttgacctcc agcacaccta ctgcaccaag ccgttttaat tcatccttgc agacttggct 237481 tggctgatga acggtcacac gaagccttgt gatacatgca tccaggttag cgatattttg 237541 ctgtccgccc aaggcctgca gcacgtgaaa ggcaagctgg tcttttgcaa ctggagcttt 237601 ctcctcattc tgaccgtctt catctgtctc acggccgggc gttttcaaat tccatttcag 237661 aatcgcaaat cggaacaaat aataataaat gaaagcaaac acgatcccga caggaatgac 237721 aacccagccg tttgtagaca gtccgtagtt caagacgtag tcaattcctc cgcctgagaa 237781 cgtatagccg tggcggacat ggaataaatc acaaacgaca aagatgacgc cggcaagaat 237841 agagttaatc aaatagagca cgggcgcaac gaacaagaaa gaaaactcaa ccggttctgt 237901 aattccggtc agcatagatg tgagcgccgc agaaatcatc acgccggaga tcattttttt 237961 cttttccgga cgcgcggtat ggataatggc aagagcaacg gccggcagac agaaaatcat 238021 gtaagggaaa tcccccatca taaagcgccc ggctgtcggg tctcccgcga aaaaccttgt 238081 caggtcgccg gttacggtgt tgcctgttga tgggtctgtg tattctccca tcataaaata 238141 gaaaggcgta taaaaaatat gatgcaggcc aaaaggaatc agcaaacgat agatcgttgc 238201 ataaaagaac aggccgactg ttgaatcggc aattaaactg ctggctgcgt taattccgtt 238261 ttggatcagc ggccaaacga atgagaaaat gacgccgatc accaatgaac tgacggaagt 238321 aatgatcggg acaaagcgtt ttccagagaa aaatccaagg accggatgca gctcgattga 238381 tgaaaatcgc ttatataaat aggcggcgag aagcccgata atgattcctc cgaaaacccc 238441 catatcaatc aggtgctcgg ctccttcata cggaggctga aggccgagta attttcccat 238501 attgtcgagg gtgacggtta aaattaagta tccgatgaca gcggcaagtc cggctacacc 238561 ttctccgccg gctaatccga tcgcgacccc cacggcgaaa atcagcggaa ggttatcgaa 238621 tacaacgccg cccgcatcct ttataatagg gatgttcagt aaatccttgt ctccgaaacg 238681 gagcaaaaga cctgctgccg gcaggacggc aaccggagtc atcaacgcgc ggccaagctg 238741 ctgcagaatt tgaaatgcct ttttaaacat gacagtctcc ttttattgtg ttatgagaat 238801 gatgcactct ttaatttttg agctgcttta taatcggcga taacggttac atgattgtgt 238861 ttttgaagaa tggaggctgg tacatctgtc gtgacaggac cttcagccat cttttgaatg 238921 gcgtctgctt tttcctcgcc gcttgctaaa agcacaatat gtttgctgaa ttccatgatg 238981 gttttaatgc ccattgaaat cgcgagtctc ggaaccagca ccggatcgcc gccgaagaat 239041 ctggcatttg cctgtatcgt gctttccgag agcttcacaa cacgtgtccg gtcttcaaaa 239101 tcagatcccg gttcattaaa accgatatgg ccattggcgc cgatgccgag aatttggaca 239161 tcaatgcctc ccgcctggcg gatgagatcc tcgtatactt tgcatgccgc ctcaagctgc 239221 ggattgtctc cttgcgggat atgaatatga tcaggctgca tattgatatg ctgaaaaaga 239281 tgctcatgca taaaatggtt ataactttgc ggatgagatg gagagagacc agcatattca 239341 tccaaattaa atgtagtaac ctttgaaaaa tcaatttcgc ctgcctgata gtctgaaatc 239401 aactgcttat acaagccgac cggtgtgctt cctgttgcca ggccgagaac ggcatctttc 239461 ttagcttgta tttgttcttt aataatggca gcgcttaact tacagagttc ttcgtagtgc 239521 tcggcgatca gaatcttcat gtgacacccc ctcaaagaga tagacaagca ccatatttgt 239581 tatgaccaat ttatgatact tgtcattacg aatttagcac cgcccttatc aaactgtcaa 239641 tattaatttc tgaaaatttg ttataaaaga aggatacaaa tctttcatat tgggagggca 239701 aatggtatta tggtctcaat gaaaaagaac ggattgcata cagaatgggg agaatgaaat 239761 gacagcttta tattctgtta tcaagtttaa aatcattgag ttaattaaat cgggcaaata 239821 tcaggcgaat gatcagctgc cgacggagag tgagttttgc gaacaatatg atgtcagcag 239881 aacaactgtg agactggctc tgcagcagct agagcttgag ggatatatta aaagaattca 239941 aggaaaaggg acatttgtat cggcggccaa aatacaaacg ccgattccgc ataagattac 240001 gagctttgca gaacaaatga gaggacttcg ttctgaatca aaagtgcttg agcttgtggt 240061 gattcctgcc gatcattcca tcgccgagct tttgaaaatg aaagagaatg aacctgtcaa 240121 caagcttgtc agagtcagat acgccgaggg ggaacctttg cagtatcata cctcatatat 240181 tccctggaag gcggcaccgg ggctggcgca ggaggaatgc accggctcgc tgtttgaatt 240241 gttaaggaca aaatacaata ttgaaatcag caggggcacg gaatcgatcg aaccgatttt 240301 aacggatgaa acgatcagcg gacacttatt aaccaatgtc ggagcgcctg cgtttttatc 240361 agaatccctt acctatgata aaaatgaaga agtggtggaa tatgcgcaaa ttattacacg 240421 gggagaccga acgaaattca ccgtagaaca gtcatatcat tcataaagca atgtgtttta 240481 agaagggaat ggtggttcta tgtttttatt tacgaatgga aaagtgctgt ggggagcagt 240541 gattgctgca ttcatccttt caattgtatt ttaccctttt ctgccgacgc agatgccgat 240601 tcattatgat gttgcgaaca gtccggatct gacggttaac aagctggcgg ggactgtgat 240661 gctgcctgtt ttgatggtgg tgtttgcatg ggcgcggaag atcaattggc aatttgtatt 240721 cgcagtgtat attttgctga tttgccacat tgtcgtcctt tgtttagcgc tctaaatcaa 240781 acagccagaa taaaactggc tgttttcttt aatttcagct tcatctgaca atgaatgtgg 240841 tgtataatag ctgatgatcc taaagaatat tctgaaattt ataggtgtga agcggcgtat 240901 tattaaagga aaggctgtat actttttgca gctttaaaaa gactgaatat ttaaacaatt 240961 atgtgaaagg tgtgctgatt agattgaata agcttattga acgagaaaaa actgtatatt 241021 ataaggaaaa gcccgacccg tcttccttgg ggtttggaca atattttaca gattatatgt 241081 ttgtgatgga ctacgaagag gggattggat ggcatcatcc gagaattgcg ccgtacgcac 241141 cgcttacgct tgatccgtct tcatctgttt ttcattacgg ccaggctgtt tttgaaggat 241201 taaaagcata cagaacagac gacggcaggg tgctgctgtt ccgtccggat caaaatatca 241261 aacggctgaa cagatcgtgt gagcgcatga gcatgccccc tttagacgaa gagctggtgc 241321 ttgaggcatt gacgcaatta gttgagctgg agaaagattg ggttccaaag gaaaaaggaa 241381 cgtcactgta tattcgtcct tttgtcattg ccacagaacc gagtctcggt gtgaaggcat 241441 ccaggagcta tacatttatg atcgtgcttt cgcctgtcgg ctcctattat ggcgacgatc 241501 agctgaagcc ggttagaatc tatgtcgaag atgagtatgt gagggcggtc aacggaggag 241561 tcgggtttgc aaaaacggct ggaaactatg ccgccagtct tcaggcacag cggaaagcga 241621 atgaactggg ctatgaccag gtactgtggc tggacgccat cgaaaagaaa tatgtggaag 241681 aagtagggag catgaacatc tttttcgtca taaacgggga agctgtcaca cctgctttaa 241741 gcggaagcat tttaagcggg gttacacgtg cgtctgcgat tgaattgatt cgaagctggg 241801 gcattccggt tcgtgaagag agaatatcga ttgatgaggt gtatgcggcc tctgcacgcg 241861 gagaattgac agaggtcttt ggcacaggca cggcagcagt cgttacgcct gtcggtgaac 241921 tcaacatcca tggaaaaacg gtgattgtag gcgacgggca aatcggggac ctctcgaaaa 241981 agctgtatga aacgataaca gatattcagc ttggcaaggt aaaaggcccg tttaactgga 242041 cagtggaagt gtgaaaatcg aaaaagaacc tgcccggagg caggttcttt ttattttgaa 242101 tgagtcatat cagcagccgg ctggcttttg cggtttttta cataatatat tgcatagcaa 242161 atggccataa atggaacgcc gcaatagagt gcgattcttt gattcggatc aaaggcaatg 242221 ccaacgacgg aagccaggca taacaggaac gcagcaatcg gcacgaacgg atacaaaggg 242281 gttctgtatt tcaaatcagt aaccttgttt cccgcttcga tataacgttt tctgaacatg 242341 aattgagaag cagcgattcc catccacacg acaacgacgg caaaaccgga aatcgacacg 242401 agcacaacgt atacagtgtc tggcgcaaat acgctggaca gcaacgacag aatgccgccg 242461 atcatgctga acaccagcgc gttaaaaggg gttccttttg acgtcagctt tgcaaatgtc 242521 ggatgaagcg ttttttcttt tgataaagac cacagcatcc gggaagaagc gtagagtccg 242581 gaattagccg ctgacaggat cgctgtcagg ataacaaagt tcatgatatc ggctgcgtat 242641 ggtacaccga ctctgtcaaa gacagcgaca aacgggcttt tgatgacacc tgcatcttga 242701 atcggaatca gccctgacag cacaaaaatt gttccgacaa agaagagcga gagacgccag 242761 accgttgttt ttatcgcttt tggtatcgtc ttgtcaggat caacgctttc accggctgcg 242821 attccgatta gttccgttcc cgaaaaggca aaattgacgg acagcatcgt catcaaaatc 242881 gggacaaatc cattgggaaa aagcccgcct tccgccgtga agttggacag catcggagcg 242941 gcttctccgc ctttgatcgg gatgatgccg aacatggcag agccgcctaa aagaataaat 243001 aatacaatgg ctaatacttt gatgctggaa aaccaaaatt ctgattcagc gaaaaacttg 243061 accgaaaatg cgttaagcaa gaagatgaac agcgcaaaga cggcactcca catccaaacc 243121 gatgtatggg ggaaccagcg ctgcattaac aggccggctg ctgtgaattc tgatcccaat 243181 gccacggtcc atgtcagcca atacagccaa gcgaccgtaa atccggtgcc cggccctatg 243241 tatttggctg cataggtgtg aaaggcgccg gtcacaggca tggcgactga cagctcaccg 243301 aggcatagca tgaccagata gacgatgccg gccccgacta agtaggcgag tatcgttccg 243361 gccgggcctg cttgctgaat ggtataacct gagcttaaaa acagcccggt tccgatgaca 243421 cctcccaagg aaagcataaa gaggtgccgg cttttcatac ttctctgaaa ggttgtctca 243481 ttcttgttgt gggcagagtt catctttttc caactttcta tcagcgattt atttccttcc 243541 taataaaaaa tctcatgtca gaaagtgaca cgagactccg gcgaaccggc tttaagttag 243601 aatatacaaa ctattccgat aagtcaagtt gtttttaaag agcgggccca agccgcaatt 243661 tcttgaatat tttcgggttt tgtccggcag cagccgccaa tcagcctcgc tcctttttca 243721 tgccaggtgc gggcgctcgc cccgtaagat tctgcgcatg ctgcgccgtt ccacgttttt 243781 gtttccggat catattgctc acctgaattc gggtagacaa tgatcggttt tgacgtgttc 243841 ttttttaact cctctatcaa ggaagggata tgctgaagcg gcgtgcagtt gatgccgagt 243901 gctgcaattt ggcggtgttc atcaagccac gatgcgcagt cagctgcagg tgttccgtca 243961 ctgatatgca agccgtcttt agcactgaag ctgatccatg catacgtttc aggaaattcc 244021 ttcaacagcc gaacaatcgc tttggcttca gtcagacacg gaatcgtttc gcatgccaat 244081 acatcagctc cggcttcaat cagcgccttc atccgggggc gatgaaattc aatcagttca 244141 tcttctgata ttgcgtagtt gccgcgatac tcagacccgt ctgcaagata agcgccataa 244201 gggcctatag aagccgcaat gatcggtttt ggccgattca aacggttctc ttcaagcgac 244261 caaaattcat cacgtgcttc agctgcgatg ctgacggaca actcgatgag ccggcgtgct 244321 tccgcttcgc tcagcccgcg tgcggcaaag ccttcaaatg tagactgata gctggcggtg 244381 attgcacaat cggcgcctgc cgcaaaataa tcagtatgaa cttgtttaat cagctccggc 244441 tcttccatca ggatttttgc cgaccacaga ctgtcattca aattacagcc cttgcgttca 244501 agctcggtcg ccatggcgcc gtctagcaca ataagcgggt atgtatctaa tatgtgttgg 244561 ataggattca tagaatgtac cgatgccttc tttcagattt ttttgaaaaa gatatgaaaa 244621 tcgtaatgga ggcttacgtg tttgtcaata aacgcaaaaa gagaaaggtg ttcagcccat 244681 atgtctgaac acccttttct tatgatattt gtttgttgtg cgtgtcagtc tttgtgtctg 244741 aaaccggcca gcactcaatg ccattatggt ttttgagcac atctttataa aagaccggat 244801 ccttgcctgc ttttttctgg cgtgtatagt ctttcagcgc cgtaaaaacg acctttgata 244861 gtaagaaaat cgcgattaaa ttcacgatga ccatcaaacc catgaacaaa tcagcaagat 244921 cccagacgag ctggactttg gcaacacagc caaacacgat cattgccagc acgccgatac 244981 ggtagacaaa aatcagtttt ttgcttttgt tcaaaaagcc gatattggtt tcgccataat 245041 aatagtttcc aattagagca cagaatccga ataacaaaat cagaatcgcg agaaagcctg 245101 atgcccatga tccgacatgg gagctgaggg aggcttgtgt caaggcgatt ccgctcagac 245161 ccggagtatg ataggcatcc gaaaacagaa tgataaaagc ggtgcttgta caaatgacca 245221 gtgtatctgt cagtacacca aaagcttgga tcagcccctg tttgacggga tggcttgttg 245281 tggcggtggc agcggcattt ggtgcgcttc ccattcccgc ttcgtttgaa aagattcccc 245341 gtctgacgcc ttgcatgagt gccgcgccca aagccccgcc ggcggcctgg tcaaaaccaa 245401 acgcattttt cacgattagc gcaagcacac ctggcagctg cgtaatgttg gagaaaatga 245461 cgaaaaacgc aactccgata tacaggacag ccaatacgac gacaatggat tcagccagct 245521 ttgcaatgcg cttgactccg ccaaaaataa tcgtgccgaa tacagcaatt aaaatgagtc 245581 ccaatgtcag gcggtttgtg ccaaacgcgt tttcaaaggc aaggctgact gtattggatt 245641 gaaccgagtt gaagacgata ccgaacgata aggtgattaa cacagcgaac agcgcgccca 245701 tccacctttt gttcagccct ttttccatgt aatacgccgg cccgccgcgg aagccgttta 245761 catcttttac tttataaatc tgagccagtg tgctttccac aaagctggat gctgatccga 245821 taatggcgat aatccacatc cagaagattg caccgggccc gccgagtgca atggcgatag 245881 caatgcccgt aatatttccc gttccgacac gggccgccat gctgatgcaa aaggcttgaa 245941 acggagaaat gctgtttttt gaccgggaag cagcaccttc tcttaatacc ctgaccattt 246001 ctttcagcat gcgaacctgt aaaaacttaa gcctgaacgt aaaatagatt ccaaaagaaa 246061 ggagcaaaac aattaatagc tttgaccaca aaagatcatt tgcaataccg acgatatgtt 246121 ctaggatttg ctgcatagaa tcacctcttt tttcatgttt aaaaaatgct gagctcccat 246181 tcctgcgcca tatgcttcag cagcataccg ccagtgaggc tgttgccgta ttcatcaatg 246241 gcaggcccgt aaatgccgat gccgcatccg gattgaaaag gctgttctct tctggcgctt 246301 ggaggcacca gcgccatgat gccgccggag acgccgcttt tggccggcac gccgacaaac 246361 gccgcatatt tgcctgaagc gttgtacatg ccgcacgtca gcattaatgc cttggccaat 246421 tttgccacat cttttggaat cacctgctcg tgtcgaatcg gatgataccc gtcatgagca 246481 aggatcaggc cgatcaacgc aatatcttct gtagtgctct ccatagcgca ttgcttcaag 246541 tacacctcaa gtgtttcttc tacttcagct tctaaaaagt ttgtttcttt taaatagtag 246601 gccagcgctc tgttgcggtg ggcggtttcc cattcagaac ggaatacttc ttcatgaatt 246661 cttggccgtt ttcctatcaa agtttccatc accgagtaaa gaaactcgag cttttcgtat 246721 gcagattctc cgggaaggat cgaagcgatg gtgagggcac ccgcgttgat catgggattg 246781 aagggctttc ccggcttgtt gatttcgagc cgaatgattg aattaaaggc gtcacctgtc 246841 ggctcgacat ctacgcggtc aagcacatag ggaatgccgc ggctcatgca ggcggcaata 246901 aagctaatca cttttgaaat gctttgcatg gtaaaagaga cgttccagtc gccggcgtgt 246961 atcatcgttc catcaggctc caatacacag atgccgagct gtgaatcatt gacttttcct 247021 aaagcgggga tatagtttgc gctttgtcca ttggcggcaa aagggcgata gtattcaacc 247081 caatcatgaa gctgtaacgc cgggtttatg tctttctggt gctcttttat caattctttc 247141 atcgaattcc tcctcactga tttttttctt aaaggactga ggtgtatcaa aacgaaggct 247201 aagggggcgt taaacgcttt cataatagcg gaaggtataa ttactgtata atggagacta 247261 cagaatcata caaaatacga caaaaacatt ttgaaaataa gcagtaagat ttataaaaac 247321 ctcatgttct gggtcaaaag caatttgcag gttttctccc gattccccaa aataaaaagc 247381 gaggatgtga tcaacataaa actggaacgg tttattgaaa aagacggata tatactggcc 247441 ctcatgctga ttacggtgcc gctggccggt gaactgaaat tttatcccct caatgaagaa 247501 ttccgggtca gctttggggc accggttttt ttcttctttt tatcattgtt gcggcatgtg 247561 cccgctgtgc tgccgggttt tctgactgga gcggctgttt tcatctttcg cgtctttctg 247621 gaattatggg gcggaggaca caatgggctg actccgattc tgtatgatca agcgtctggc 247681 tttttctttt atatgactta cgcctgtctg ttttccatat taaaggccaa tcgtttccgt 247741 gaacggccga ttatgctcgg tttcattggg tttatgattg aagttgtgtc agattgtgtc 247801 gagctaactg tgcaatttct catttttcat acggttgtca cgcctgagaa aatcactgac 247861 attgcggtga ttgcgatttc tcacacattt attgtgatga gcttttatag tgtgctgaag 247921 ctgtatgaaa cacaatcgag agaaaaacag acaaggcagc agcacgagca catgctgatg 247981 atcgtttcca atttatatga agaaacggtg cacctaaaaa agacattgaa aacgacagag 248041 aaagtgacaa acgattcgta tcagctctat cgggaaatga agggcaagga tgttcagctg 248101 agcggcagaa tcctgagact ggccggagag attcatgaag tgaaaaagga caaccagcgg 248161 atattcgcag ggctttcaaa actgatttcg aatgagagtt tgagagatta tatgagggct 248221 tctgatttgc tgcagctcgt gattcgaatg aatgaaaagt acgctgaagc actagggaag 248281 cagattgatt tttactgctc gatcgaggga gagcatgacg aatatcacgt atttatcgtg 248341 ctttcgatca ttaataatct aacagcaaat gcggtagagg ctatggatga agagggaatg 248401 gtcagcctga ggctccgtaa gccaaatgag agtatggtag aattccaggt ggaagacaat 248461 ggccccggga tttccgagaa aatcggagac attgtgtttg acccgggctt tacttcaaaa 248521 tatgacgaat ttggcacgcc ttctacgggt atcggacttt cctacgtaaa ggaaatcgtg 248581 acagagctag aaggggatat cacgtttgat aatcagcagc ggggagtggt gtttgccatc 248641 aggctgcctg tccggcattt gattcagaaa gggtgaacca aaagctatgc gtttttttat 248701 tgcagatgat gaccgtgcgg tgcggtcaat tttaaggcag atcattgagg acgaagatct 248761 cggggaagct gctggtgaag cagacgacgg aagccaagtg gaagggcata tgctgcaatt 248821 taagcagatt gatattttat taatcgatct gttaatgccc ggaagagacg gcattgagac 248881 gattcgtcag atccagaata cgtactccgg caaaatcgta atgatctctc aagtggaggc 248941 gaaggaaatg gtcggggaag cgtactcgct cggcatcgaa tattttatcc ataagccgat 249001 taaccgcatt gaaattgtca cggttctcca aaaggtgaag gagcggatcg agcttgaaca 249061 ctcgattgga gccattcagc attctctaag ccggcttgtc aatcggactg aacggaaagc 249121 gcgtccccag cagaagagtg acagcggttt aaaagaggca ggaacattcc tgttgtccga 249181 gctgggcatg atgggagaag gcggcgcaca tgatctcatg gcggtcctgc agtatttagc 249241 agaacacgag caatccgagc cgcacgaaaa acaaagccct tcgctaaaac aaatattcac 249301 ccaagtagcg gtacggaagc tggggacagg agcctcacag acggaagtca atcgcgaaat 249361 gaaagcctcg gagcagcgta tccgcagagc gattattcat tcgctgcacc attttgcttc 249421 actgggcaca actgattttt cgaatccaaa atttgaaacc tatgcatcga aattctttga 249481 ttttccggtt gtcagccaga aaatgaaaga actccaatcc aaggatgcaa aaccccttgc 249541 acctgctaga ataaatatga aaaaattcat ccacgtgttt tttttggaag caaagctttt 249601 gcatgagacg atgaaacaaa gaaggatata aaccaaacag ccggctgacc aggctgtttt 249661 tttgctgcgc agaatcccgg ccggacagtg atttaccgct tttttataaa atatcagaaa 249721 ataaagatat tgacttattg tttatttgtc ttacaattaa acaaaaggat atatgggaag 249781 gagcggatgt gaaagaaaaa ttaataaaag cgcttacaga tagaggccgt atacacaaat 249841 aacaggaggt tatgttgatg agccgtatca gaaaagcacc cgctggaatt ttaggttttc 249901 cggttgctcc ttttaacaca caaggaaaac tggaggaaga agctcttttt caaaacattg 249961 agtttttgct gaatgagggc ttggaagcga tatttatcgc ttgcgggtct ggtgaattcc 250021 aatctctcag ccagaaggaa tatgagcaaa tggtggaagt cgcagtctcg gcagccggag 250081 gaaaggtgcc ggtctacacg ggggtgggcg gcaacctcag cacagcgctt gattgggcgc 250141 agctgtcgga gaaaaaaggc gccgacggct acttgattct gcctccgtat ttggtgcatg 250201 gcgaacagga ggggctgtac cagtatgcga aaacgattat tgaaagcact gacttgaacg 250261 cgattcttta tcagcgcgat aacgcagttc tctctgttga acagatcaaa cgtctgaccg 250321 aatgtgaaca gcttgtcggt gtcaaagacg gggtaggaaa tatggatttg aatatcaatc 250381 tcgtctatac gatcggcgac cgcttgggat ggctcaacgg aatgccgatg gctgaagtga 250441 cgatgccggc ttatctgccg atcgggttcc actcttactc ttcagcgatt tcaaattata 250501 tcccgcatat ttcgcgaatg ttctatgatg cattgaaaaa cggaaatgac gagcttgtga 250561 aggaactcta tcggcatgtg attctgccga tcaacgacat tcgcaaacaa cgaaaaggct 250621 acgccgtatc cttgattaaa gccggtatgg aaatcatggg tttgaatgta aggaatacag 250681 ccagaccgcc tgtcggcccg gttgaaaaag atcattatca gcaattggaa gcaattttga 250741 agcaggcggc tgaccgtttt ccgaaaaaag ccgcgacggt ttgaccagaa aaaacacgaa 250801 aggggcaatg ggcatgtctg tgatcacgga acaaaacacg tacctcaact ttattaacgg 250861 agagtgggtt aagtctcaat caggcgatat ggtcaaagtc gaaaaccctg ccgatgtgaa 250921 tgatattgtc ggatatgtac agaattcaac ggctgaagat gtggaacgtg ccgtcaccgc 250981 cgccaatgaa gccaaaacgg cttggagaaa gctgacgggt gccgagcgcg gccaatactt 251041 atacaaaaca gcggatatca tggagcagcg cttggaggaa atcgccgcct gtgcaacgcg 251101 tgaaatgggt aaaacattgc cggaagcgaa gggagaaaca gcccggggga ttgccattct 251161 gcgctattac gccggagagg gcatgcgaaa aacgggtgac gtcattccgt ctactgacaa 251221 agacgcgctc atgtttacca cccgtgttcc gctcggtgtg gtcggtgtga tttctccgtg 251281 gaacttccca gtggcgattc cgatttggaa aatggcgccg gcattggtat acggcaatac 251341 cgttgtcatc aaaccggcga cagaaacagc tgtgacatgc gcgaagatca ttgcctgctt 251401 tgaggaagcg gggctcccgg caggggtcat caatttggtg acaggcccgg gttctgttgt 251461 cgggcagggg cttgctgagc atgacggtgt aaacgccgtt acgtttaccg gttcaaatca 251521 agtcggaaaa atcatcgggc aagccgcttt agcgagggga gccaaatatc agcttgagat 251581 gggcggcaaa aaccctgtca tcgtagctga tgacgctgac cttgaagctg cggcagaagc 251641 tgtcataacg ggggccttcc gttcaaccgg ccagaaatgc accgcgacaa gccgtgtcat 251701 cgtacaaagc ggaatttacg agcgctttaa agaaaaactg ctccagcgca caaaagatat 251761 tacaatcgga gacagcttaa aagaggatgt ctggatggga ccgatagcca gcaagaatca 251821 gcttgataac tgcctgtcat acattgagaa aggcaaacag gagggcgctt cccttttaat 251881 aggaggagaa aagctggaga acggaaagta tcaaaacggc tattatgttc agcctgccat 251941 ctttgacaat gtgacatctg agatgacaat tgcccaggag gaaattttcg gtccggtgat 252001 cgccttgatc aaggtggact cgatagagga ggcgctgaac atcgccaatg atgtgaagtt 252061 cggtttaagt gcatccatct tcacggaaaa catcggccga atgctttctt tcattgatga 252121 aatcgatgcc gggctggttc ggatcaatgc agaaagcgca ggtgttgagc tgcaggcgcc 252181 ttttggcggc atgaagcagt cgagctccca ctcccgagaa cagggtgagg cagcgaagga 252241 ctttttcaca gcgatcaaaa ctgtttttgt gaagccgtaa tggtgctgga aagaggcgtg 252301 cgtctctttc ccggtttatc acaaccagca tatgattctc tactttgaaa aggagaagat 252361 actatgaaaa aagactttgc gagtgttact ccggcgggca aaaaaacgtc cgtgcgctgg 252421 ttcatcgtgt ttatgctgtt tcttgtgacc tctattaact acgcggatcg agcgacgctt 252481 tccatcaccg gagattccgt ccagcacgat ttgggattgg actcggtcgc catgggatat 252541 gtcttttctg cctttggctg ggcctatgtc atcggacagc ttccgggcgg ctggctgctg 252601 gaccgttttg gttcaaagac tatcattgcg ttaagcatct ttttctggtc gttttttacg 252661 ttgctgcaag gggcgattgg ctttttctcc gccggcacag cgattatcct gctgtttgca 252721 ctgcgttttc tggttggttt atcagaagcg ccttcatttc ccggaaacgg cagagttgtt 252781 gcctcatggt ttccaagctc cgagcgcggg acagcttcag ccttttttaa ttcagcacaa 252841 tacttcgcaa tcgtcatttt ttctccttta atgggctggc ttacccactc tttcggctgg 252901 cattccgttt tcgttgtcat gggtattgca ggcattcttc tggctgtcat ctggctaaaa 252961 acggtgtatg aaccgaaaaa acatccgaag gttaatgaag ctgagcttgc gtacatcgaa 253021 cagggcggcg ggctgatttc catggatgac agtaaaagca aacaagaaac agaatcgaaa 253081 tggccgtata tcaaacagct gttaacgaac cgcatgctga ttggcgtgta catcgcgcaa 253141 tactgtatta cgactctcac ctatttcttt ctcacatggt ttccggtata tttggttcag 253201 gcccgcggca tgtctattct tgaagctggg tttgtcgctt ccctgccggc gctgtgcgga 253261 tttgccggcg gcgtgcttgg gggcattgtg tcagacatct tactcaaaaa aggccgttca 253321 ctgacctttg caagaaaagt gccaatcatt gccggcatgc tgctgtcttg cagtatgatt 253381 gtctgtaact acacagattc agcatggctc gtcgttgtca ttatgtcgct cgcgtttttc 253441 ggaaaaggct tcggcgcatt gggttgggct gtcgtgtcgg acacgtctcc gaaagaatgt 253501 gcaggattaa gcggcggttt gttcaacact ttcgggaata ttgcctcaat tacaacaccg 253561 attattatcg gatacattgt caatgccact ggatctttca atggcgcgct tgtgtttgtc 253621 ggcgctaacg cgattgcggc gatcctcagc tatttgctgc tggtcgggcc gatcaaacgg 253681 gtcgtgttaa agaaacaaga acaagacccc gatcaatcgt tgcctgtcta atatttatga 253741 aagcgcttta taaagggagg aaaatgcatg agttcaccga tacaagagca ggttcaaaaa 253801 gaaaaaagat cgaatattcc ctcaatttct gaaatgaagg tgattcctgt tgcgggacat 253861 gacagcatgc tgctgaatct aagcggagca cacagcccgt tttttacccg gaatatcgta 253921 atcttaacag acagcagcgg aaatcaggga gtcggcgagg tgcctggcgg agagcatatt 253981 cgccgcacac tggagctgtc agagccgctt gttgtcggaa aatctatcgg tgcgtaccag 254041 gcgatattgc aaacggtcag aaagcagttt ggcgatcagg acaggggagg gcgaggaaac 254101 cagacgtttg atttgcgcac cactgtgcac gccgtcaccg cactggaagc ggctttgttg 254161 gatttgcttg gaaagtttct tcaggaaccg gtcgcggctt tgctgggcga agggaagcag 254221 cgtgatgaag taaaaatgct cggttacctc ttttacatcg gcgaccgaaa tcggacgacc 254281 ttgccgtatc aaagcgatga gcagtcagat tgtgcgtggt tccgtctgcg ccatgaggaa 254341 gcgctgacgc cggaggccat tgtgcgtctt gccgaatccg cacaggagcg ctatggcttt 254401 caggatttca aattgaaagg cggggtgctg cggggagaag aggaaatcga agctgttacc 254461 gcattatcga aacgttttcc agaggcaagg atcactcttg atccgaacgg ggcatggtca 254521 ttagaggaag ctattgcatt atgcaaagga aagcaagatg tgctcgcgta tgcggaagat 254581 ccatgcgggg atgagaatgg ctactccgct cgtgaagtaa tggctgaatt ccgccgcgcg 254641 acagggcttc cgactgcgac aaatatgatt gcgactgact ggcgggaaat gggtcacgcg 254701 attcagctcc acgcggtcga tataccgctg gctgatccgc atttttggac gatgcaaggg 254761 tcggtgcggg ttgcgcaaat gtgccatgat tggggtttga catggggctc gcactccaac 254821 aaccactttg atatttccct tgcgatgttt acccatgtgg cagcagcggc tccggggcgg 254881 atcacggcga ttgataccca ttggatctgg caggacgggc agcgattaac gaaacagcct 254941 tttgagattt cttctggctg tgtcaaggtg ccggataagc ctggactagg cgtcgatatt 255001 gatatggaac aagtggaaaa agcgcatgag atctatcgga aaatgaattt aggcgcacgg 255061 aatgatgcga tcccaatgca gttcctgatc agcaactggg aatttgaccg gaagcgcccg 255121 tgtcttgtgc gataagtttg attgtaaata ttgtcatatc cgctattttg tcttacaatt 255181 gaacaactga agggagagtt gttcgtgtac gaaggtttag aggatttgaa agtcgataca 255241 gtcaatcgga aaacattagc caagcaggtc atcgaacgga ttgtccattt attatcgagc 255301 ggacagttga gggccggaga caaattgccg acagaaatgg aactgatgga cattttgcat 255361 gtcagcaggc cggtgctacg ggaagcactc agttcacttg aaacgctggg cgtcattacg 255421 agaaaaacac gagggggcac atatttcaac gataaaatcg gcatgcagcc attttccgtc 255481 atgcttgctt tggccactga taatcttccg gctatcattg aagcgcggat ggcgctagaa 255541 ctcgggctcg tgacaattgc cgcggaaaaa atcaatgagg aagagcttca gcgtttgcag 255601 aagacgatcg acgatattgc caacagcact gacaatcatt atggtgaagc ggataaagag 255661 ttccatcgaa ttattgcgtt aagcgccaat aaccccgtcg ttgaagggat gattcagtcc 255721 ctgctgatca cccatgcgaa aattgacagc caaattccgt acagggagag agatgtaacg 255781 gtcgaatatc acaaaaaaat ctacgacgcc cttgccaaaa gagatccgta caaagcacat 255841 taccacatgt atgagcatct gaaatttgtc cgtgacaaaa ttctaaaagg aatggatgaa 255901 aaataatggt gagcaaccgc agttgaaacg taagagctgc ggttttttta aaccaattta 255961 gaaaacgctt actaaaatat gaggagtgat tttcatatgg cgatgaacct caggaagaac 256021 caagcccccc tttacatcaa agtgcatgaa atagataaca ccgcgattat tgtaaatgat 256081 ggagggctgc caaagggcac tgttttctca tgcgggctcg tacttgaaga ggatgttcct 256141 caaggccata aggtggccct caccgatctc aatcaagggg acgagatcgt gcgttacgga 256201 gaggtgatcg gatttgctga tgagacgatc aaacgcggga gctggatacg ggaagccctc 256261 gtgagaatgc ccgctcctcc ggcgttagac gatcttcctc tcgcaaacag ggtgccgcag 256321 ccgcggcccc cacttgaagg atatacattt gaaggatacc gaaatgcgga tggcagtgcg 256381 gggacaaaaa atatcctcgg catcacgaca agtgttcaat gtgttgttgg cgttttggat 256441 tatgcagtca aacgaataaa agaagagctg ctgccgaaat acccaaatgt cgatgacgtt 256501 gtgccgctgc atcatcaata cggatgcggc gtggcgatca atgcgcccga cgctgtcatt 256561 ccgatccgca cgattcaaaa tcttgcgaag catccgaact tcggcggtga agtaatggta 256621 atcggattgg gatgtgaaaa gctcctcccg gaaagaattg cctccgaaaa tgatgatgac 256681 attctatcgc tccaggatca ccgaggtttt gcggcgatga tccaatccat tttggaaatg 256741 gcggaggaac ggttaatcag gctgaacagc agaacccggg tgtcatgccc tgtttcggat 256801 ctggttatcg gcctgcaatg cggcggcagt gatgcgtttt ccggcgtgac ggcgaaccct 256861 gccgtggggt atgcggctga tttattggtt cgcgcaggtg caacggtttt gttttctgaa 256921 gtgacagagg tgcgggatgc cattcattta ttaacgccgc gggctgtcag tgaagaggtc 256981 ggacaatcgc tgatcaaaga gatgaagtgg tatgacagct atcttcggcg gggagacgca 257041 gaccgtagcg caaacccgtc accaggcaat aaaaaaggcg gattatccaa tgtggtggaa 257101 aaagcgttag gttcggtagc gaaatcaggc acaagcccca tctccggcgt gctcggccct 257161 ggtgaaagag caaagcaaaa aggcctgctg ttcgcggcga caccggcaag cgattttgtg 257221 tgcggcaccc tgcagctggc tgcgggcatg aatttgcagg tgtttacgac agggagagga 257281 acaccatatg gcctggctgc tgcgccggtt ctgaaagtat cgacgcggca ttccttatca 257341 gagcattggg ctgatttaat cgatatcaat gccggccgaa tcgcgacagg agaggccagt 257401 atcgaagacg taggctggga aatcttcagg acgattttgg atgtggcaag cggccgcaaa 257461 caaacgtggg cagaccgttg gggtcttcat aatgatttgt gcttgtttaa tcctgctcca 257521 gtgacttgat tcatgttttt atagcggaaa gatggaatat gctgtaaaat gaaaatcagc 257581 gtataggaaa cggaggggtt acagcatggc attcattaga ttccgagtga cacgaattca 257641 atagtgaaca actctcgcct gaatgcgaga gaatcgggat gaatccgcct atgtatgagc 257701 ccttatatgg ttatcaaaaa agagggtggc gtgcctgccc ttttttgtgc cttcaagcat 257761 cccttctctc tactgcaggc cggagcatga gaaaggggaa atgggatgac aaaccttaac 257821 gaaaaacagc ttatcactga gattgtcggg cttgcacgca gccaaggttt gacggttcat 257881 tctgagaacg cgcaattgaa tgaaaccgga atggactttc aagttgtatt tgccaaggac 257941 gacacaggta tgccatgggt gctgcgaaaa ccgcggcgaa gtgatgttgt ggaaagagca 258001 tctgcagaag gcataacgct tgcctttctc cgcgcgaatc tgactgctga tgtgccggat 258061 tggagaattc atacaccgga attgatcgct taccccatgt taaaaggaac gccggctgct 258121 ggaattgact tggaacaaaa gcaatatgta tggaatatgg atcatcagcc gccgtcagac 258181 gactttgtcc gcacacttgc cgacatactg gctgaattac atggcacgga tcaaatatct 258241 gctgggcaat ccggaataga agtgataagg ccagaagatt tcaggcaaat gacagcagac 258301 tctatggttg atgtgaagaa taagcttggc gtatctacga cgctttggga aagatggcaa 258361 aagtgggtag atgatgatgc atactggccg ggtttctctt ctttgataca cggcgatctc 258421 cacccgccgc atatccttat cgatcaaaat ggacgtgtca caggacttct ggattggaca 258481 gaagcgaagg ttgctgaccc agccaaggat tttgttcttt atcaaaccat tttcggagaa 258541 aaagaaactg cccgtttgct tgaatactat gatcaagcag gcggccgaat atgggcaaaa 258601 atgcaggaac acatctcaga gatgcaggcg gcgtatccgg tggaaatcgc caagctagct 258661 ctgcaaacac agcaggagga acacatcaat atggcgctgg aagcacttgg tgtaacatcg 258721 gattaagaat tgacttcgtt tcatgaaccg agtattataa actctacaaa taatagaacg 258781 gattaacaat cgtgaggaag agcaagtacg catcagaatg gaggttcaga gagtcggtgg 258841 caggtgtgaa ccgatcctcc cctgatgccg aatgggcttc tgaattgctt tgctgaacgg 258901 atagtaggcg atgccgggtt tctctccccg ttaccaagag aggagtatcg aaacataggt 258961 tttctgtact tagagtgaac ggctgtatag ctgttaataa aggtggtacc gcgagaccct 259021 cgtcctttgc ataggacggg ggttttttgt gtttcttaaa ggaggtgacg gccaatgtac 259081 gatggctggt ggtggcatag cagatgagtt agaaaggagg atatcaaatg gtcattgcaa 259141 ctgatgatct tgaggtcgca tgtcctaaat gtgaaagagc gggagaaatc gaaggaacac 259201 cttgcccggc ctgcagcgga aaaggtgtta ttctgactgc tcaaggatat acgcttctcg 259261 attttatcca aaagcatttg aataagtaaa ggagaaaagc tgagctgaga tgagagcaga 259321 agagcagagt aagattcgtg aggccgcagc aggtacgatt tttttgctga tcggaacagt 259381 ttgttttgcg tctaaatcga tttggataaa atgggcatac caaatgggtg ctgagccaga 259441 tgccgtgctg ctatacaggc agctgctggc tgttccgctg ttttggctga tttttttaat 259501 ataccgtcct ccaatgccag acggtaagaa aaaaggagac ctatggaagg cttgtggcgc 259561 gggagtgttt tgtttttttc tgtctccctt gcttgatttt atcgggctga accatgtatc 259621 cgcaatggtt gaacgtatat tgctgatgag ctatccgttg tttgtgtttg gattcaccgc 259681 gtgtcgtgac cggaaaatgt cctcaattca ggaccttttc gcagttctgg cggtcatgtt 259741 tgggcttttc ttggcgctgg gcggctggaa tgctgagctt ttccaggcga atatgattgg 259801 agctgtattc attttgttat cttcggccgt ctatgctggt tatcttgtcc tttccgggca 259861 tctcgtccat caaatcggag ggatccgtct caatgcatac gggatgacag ctgctggagc 259921 tgccatgatg ctttacacag ggataaaatc ggcggctggc atgaatacgc caatggcagc 259981 atatccgctt tctatgtatg gtttgttcgc agtaattgca gtcgttacca cagtgattcc 260041 atttgtgcta atgcttgagg gcataaaacg aatcggggca cagcgagccg ccgccatttc 260101 aatggcaggg cctatcctga cgattttcta tggagcttta tttctcggtg aacggctcgg 260161 gctcattcaa gtcattggat gcggtggcgt attttttgtc attacgggca tggaatacag 260221 gaagctgaaa acaggaaaaa aagaataatt tttataaaac acacacgttt ttcaattaca 260281 ataagtgtaa ttacgtgtgt gttttttgat tttgtaaagg ttaggtgagg agatgcagcg 260341 catattgctt gtagaagacg accactcaat cagtgaaatg gtggatcatt atttaacaaa 260401 agaaggcttt ggaattgtgc atgctttcga cggagaagag ggcatccggc tgtttcagca 260461 gggttcatac gatttggtcc tccttgatat catgctcccg aagctgaacg gcatggattt 260521 tctgaaaatc atccgggaaa aaagcaatat accggtctta atgatttcgg caaaagatgg 260581 agatgtggac aaggcattgg gactgggctt tggggcggat gattatatcg ccaaaccgtt 260641 ttcgatgatt gagctgacag cccgagtaaa agccgcgata cggcgggcga cgcaatattc 260701 ggcagaggag ccggctgtga ataaggtgat ccggattcac cagcttgcga tagatataga 260761 caatgtttcc gttttgaaaa acggagagcc gctccagctg acgtcaacag aatggcagct 260821 gctgtgctta tttgcatcaa atcctaaaaa agtgtttacg aaagaacaaa tctaccgttc 260881 cgtttggaat gaagagtact ttgatgatca gaacatcatt aacgtacata tgcggcggct 260941 cagagaaaag attgaggatg acccctcctc ccctcaatat attaaaacgt tatggggcat 261001 cggttataaa ttaggagagt tttagaatga cagtgctatg ggtggccgct gtcatcgctc 261061 tggcgtgtct gaatgtgatt caattcataa tgaaaaagaa gcgggacggg aatctggctt 261121 acacggctga ccagcttagc tacatgctca gccgggattc ggcaggacaa attttgcttc 261181 ctacagacga tcatgcgctc aaagacttgc ttgttaacat caatcttatc gttgagaatc 261241 gtcagcagat cagcgcccaa tttgccaaaa cagagcaatc catgaagcgg atgctgacca 261301 atatgtcgca cgacctgaaa acgccgttaa cggtcattct cggttatatt gaagccattc 261361 aaagtgaccc gaacatgccg gacgaagagc gggaaagatt gctggggaag ctccgccaga 261421 aaacaaatga acttattcag atgatcaatt ccttttttga tttagcgaaa ttagaatctg 261481 aagataaaga gatcccgatc accaaagtac atatgaacga catatgcaaa cgaaatatcc 261541 tgcactatta tgacgctgtt cagtcaaaag gctttcaagc agccatcgat atccccgata 261601 cgccggtgta tgcgcaggcg aatgaagagg ctctggacag aatcctgcaa aacctattgt 261661 ccaatgcgat tcaatatggc gcggccggca agttaatcgg gctgacgctg tcttatgatg 261721 agaggaacat cgccatcacc gtatgggatc gcggaaaagg gattagtgaa accgatcagc 261781 agcgggtgtt tgagaggctg tacacactgg aagaatccag aaataaagca tttcaaggaa 261841 gcggcttggg tttaaccatc acaaaacggc ttacagaaaa aatgggaggc atcatatccg 261901 tccaaagcaa gccgtacgaa cggactgcat ttacgatcac attgaaacgc atgacatatt 261961 aatcgtaaga atttcttaag gtttgagaaa taaaaatgac agggctcgcc gctacaatag 262021 aaaacaggaa aagagaggga aggagaaaca aagttgactt atatcgtaca aacaaacggg 262081 ctgaccaaaa catatcaggg caaagaggtc gtatccaatg tcagcatgca tattaaaaaa 262141 ggtgaaatct atggctttct cggcccgaac ggcgcgggga aaacaaccat tatgaaaatg 262201 ctgacgagcc ttgtcaaacc gacaagcggt gaaatcatca tccttgggaa caagttcacc 262261 cacacgtcat atgaggtgct ggggaacatc ggcagcatga ttgaatatcc gattttttat 262321 gaaaacctga cagctgaaga aaatttagat ctgcattgtg aatatatggg ataccacaat 262381 aaaaaagcca tacaagaagt gctggatatg gtgaatttaa aacaaatcga caaaaaaccc 262441 gtcaaaacct tttccctcgg gatgaagcag cgccttggaa ttgcgcgtgc catcctcacg 262501 aagccggacc tgcttattct ggatgagccg gtgaatggtc ttgaccctct cggcattaaa 262561 aagatcaggc aattgtttca agtgctgagc aaagagtacg ggatgacgct gctgatctca 262621 agccacctgc tgggtgaaat cgaacaaatc gcggacacaa tcggcgtcat tcgggacggc 262681 aggctgcttg aagaggtatc aatggaggat gtcaggggcc agaacactga atacatcgag 262741 cttgtcacgc cgaatcagac aagggcctgc tttgtgctgg agaaagagct gcaattaacc 262801 aactttaaaa tattaaatga gaaaacgatt cgaatttacg aggctgaagc ctctcaggct 262861 gccatatcca aagcattgat tttaaatgat gtagacattg aatcaatgaa caaaaagtat 262921 acgtcgctgg aggattattt tatcaaattg atcaacggca atagcatcag tgcgtaaagg 262981 aggagagaca cgttgatgaa tttgatcaga atcgaattaa gaaaaatgaa aatgggctgg 263041 tatatcagag gtgccctcat tgccaacgtg atcattatgg gttttatgtg gctgatcagt 263101 tattccgaaa aagccgatgg cggggtttcg ttccaaagta cggatgaagc attcctcatc 263161 atcggcacct tcgtcagagc ggtatttatc gtatttggcg ctgtgctgat cgtaaaattg 263221 gtgatttcgg aatataaaaa caaaaccatt cttgtgatgt tcacgtaccc gatcagccgt 263281 aaaaagctgc tcaccgctaa gctcatgatc gcgggcggac tgacgtttat cacgatttta 263341 ctttcaaata tactcatagc cgccggtttc ttttggctga actcgatctg ccatttcata 263401 ccgggagagc ttacttccga gatcatttct caacaggcgg tcaaaatggc ggttttcgct 263461 tttggcgccg ctggaaccag tttagttccc atcttttttg ggatgcgtag acactcggtt 263521 ccggcgacca tcatttcatc tgtagtaatt gtgatgctca tcagctcaac aagtccgggc 263581 ttctcgattt catctgttgt gtatatcccg ttatcgttag cggcattcgg tttgttcttt 263641 tcctacatgg cgatcaggaa tgcggacaag caggatgcgt aaacaaaggc gcccaatatg 263701 tataaaaggc cgatgctgtc agcaccggcc tttccattat gagtctgttc ttgtttcaag 263761 ataatgcttc ttgccaatct ctttgctcat catatagaaa tggaagcaat attcaccgat 263821 tgccatgacg atcgcgccga ataaagccgc caatgcaact tcaccgccag tcatccccat 263881 agaaagcggc atgcccatca gccagatcac gagaaaggcc aaaccaaaat cagccaaagt 263941 tgcaatcata ttattccatt tcggcaatac ataaagatcg cccagcaaat aagaaataac 264001 ccctaacaca atcgtcatta gcagcgtatc accaaacgtg aaaccaaagc ccagaccaag 264061 caccagatac aacacaataa tcgtcataat acctttaata gcgagcgctt tcacatgtgt 264121 cattacaatt cctccttttg tcatttgatt tgttatgtat aattcctcaa atgtaaaaag 264181 ttaaacctta tttcttttcg gaggcgggtg caaatctgct ggggagaggt caatgatgtg 264241 aatccaggaa ttgaggctgc ggcgcttcga cagcggaaac gtgaagcttg tactgcaccg 264301 gacgctgctt tgatgcccaa cagcccatta tgtttgctgt ttttagatga ataaatttaa 264361 aaacttctcc tgtccctccg tcatcacttc tgaagtaatg aaatatgatg aaaagagatc 264421 aaggggaggt gacgtgatgg cggtcgtgag agcaacgagt gcggatgtcg atttgatggc 264481 aaggctgctc agagcggaag cggaaggcga aggcaagcag gggatgctgc ttgtcggcaa 264541 cgttggaatt aatcggctgc gggcgaattg ctcagatttt aaaggcctcc gcaccatcag 264601 gcagatgatt tatcagccac acgcgtttga ggctgtgact catggatatt tttatcaaag 264661 ggcgcgagat agcgagcgtg cccttgcacg ccggtcgatt aatggtgaaa ggcgctggcc 264721 tgcaaaattt agtttatggt acttcaggcc gcagggggac tgtccagccc agtggtataa 264781 ccagccgttt gtggccagat ttaagtcaca ctgcttttat cagccgacgg cggagacgtg 264841 tgaaaatgta tataacacat tttagagaca ggacaccgtt caaattgaac ggtgtttttc 264901 tttgaaaaga tgcaatgcaa aatattcctg tgagataatc aaagaaaaaa gagctgacgg 264961 agatgacaga atggcaacaa ttgacctgca aaagaaaagt gtaaagatcg tactggagaa 265021 aaagcagtta acgaaggtga cggctcgtgt tggactggtt cttgatatta cgggatcgat 265081 gagaccgctc tacaaaaacg ggacggttca aaatgtggtg gagcggattt tggcagtggc 265141 tgatcagttt gatgataacg gtttgctgga tgtatgggtg tatgataatg aattttcccg 265201 attaaagcca gtttcagaaa aggatttttc gggctatgtc gatcgtgaaa ttttaaataa 265261 tgaccgcttg cataaattcg gcagaaatga tgagccgcca gtcatgaagg acgtgctgcg 265321 caaatatgtt acggaggaac cgagctcgta tcctgctttc attgttttta tcaatgacgg 265381 gggctgtaaa aagtcaatca aaccgataat tgaagcttct tctgataaac cggtgttctg 265441 gcagtttgtc ggcatcggaa acggaaactt tgattttctc aataaactgg atacgttaga 265501 agggcgtgtc attgataaca cgaacttcct gcatatcgaa gagattgacc gcatttctga 265561 tgatgagctt tatgatgctc tgcttgctga atttccattt tggctgaaag aagcgaagga 265621 aaaagggatt gtaagagaac aagagcctcc tgctgaaaag ccgaaaaaga agggcttttt 265681 cagcagattg ttttcgaaat aactgataaa gagcactgag tcattctgcg aaatggctcg 265741 gtgtttttgt ttttttaaga tcatgtgaag aaaaataggc cgaatgggcg gcttgcaaac 265801 gacaggatat gcagaaaacg cgtcattcag ccagctttcg gcatgtttca gcagcaggct 265861 tgtgagggaa gacctgtttt taatgttcag cgcttacaat cagttcacac ttcttcacag 265921 tcgtttaaca atgatttcct ataatggaga cgatcaatga ggagagaggg gatcttgaat 265981 ggcatacgac agtcgttttg atgaatgggt acagaaactg aaagaggaaa gctttcaaaa 266041 caatacgttt gaccgccgca aatttattca aggagcgggg aagattgcag gactttctct 266101 tggattaacg attgcccagt cggttggggc ctttgaagta aatgctgcgc ctaacttctc 266161 aagctatccg tttacattag gggtagcgtc aggtgatccg ctttctgaca gtgtcgtgct 266221 ttggacacgt ctggcaccag atccgctgaa tggcggggga atgccgaagc aagcagtgcc 266281 tgtcaaatgg gaggtcgcaa aggatgagca tttccgcaaa atcgtaagaa aaggcactga 266341 aatggctaaa ccaagtcttg cccattccgt tcatgtggaa gcggacgggc ttgagccaaa 266401 caaagtgtac tattaccgtt tcaaaaccgg ccatgaacta agccctgtcg gaaaaacaaa 266461 aacactgcct gcccctggcg ccaatgtgcc gcaaatgacc tttgcatttg cttcctgcca 266521 gcaatatgag cacggatatt atacggccta caagcatatg gcaaaggaaa agcttgatct 266581 tgtcttccat ctcggtgatt acatatatga atacggccca aatgaatatg tatcaaaaac 266641 aggcaatgtc cgcacgcaca acagcgcgga aatcattacg ctgcaagact atcggaaccg 266701 tcacgctcaa taccgttctg acgccaatct taaagctgca catgcggcat tcccttgggt 266761 tgtaacttgg gatgaccatg aagttgaaaa caactatgcc aataaaatac ctgaaaaagg 266821 acagtcggtt gaagcattcg tgctccgccg cgcggcagca taccaggcat actatgaaca 266881 tatgccgctc cgcatttcct ctttgccgaa tggcccagat atgcagctgt accggcactt 266941 tacgtacgga aacctggcgt ccttcaatgt gcttgatacc cgccagtaca gggacgacca 267001 agccaataac gacggcaata agccgccttc tgatgaatcg cgcaatccga atcggactct 267061 gcttggaaaa gaacaggagc agtggctctt caacaatttg ggcagctcga cagcccactg 267121 gaatgtgctg gcgcagcaga ttttctttgc caagtggaat ttcgggacaa gcgcaagccc 267181 gatctacagc atggattcgt gggacggcta cccggctcag cgcgaacggg ttatcaattt 267241 cattaaaagc aaaaatctga ataatgttgt cgtactgaca ggtgatgtac acgcaagctg 267301 ggcatcgaat ttgcatgtcg atttcgagaa gacaagttca aaaatattcg gagccgaatt 267361 tgttggaacc tcgatcactt ccggagggaa cggagcggat aagcgagcgg atacggacca 267421 aattttaaaa gaaaatccgc acatccagtt ctttaacgac tatcgcggat atgtccgctg 267481 tacagtgacg cctcaccagt ggaaagccga ttatcgggtg atgccatttg tgaccgagcc 267541 gggcgcagcc atttccacgc gggcttcatt cgtttaccag aaagaccaaa ccgggttgag 267601 aaaggtatca tccacaacaa tccaaggcgg ggtgaagcaa tccgatgagg tcgaagagga 267661 tcgtttcttt tcgcacaaca aagcccacga aaaacaaatg attaagaagc gtgcaaaaat 267721 cacgaattaa ggagtggaaa ttatgttttc aaacattgga ataccgggct tgattctcat 267781 cttcgtcatc gccctcatta tttttggccc ttccaagctg ccggaaatcg ggcgtgccgc 267841 cggacggaca ctgctggaat ttaaaagcgc cacaaaatca cttgtgtctg gtgatgaaaa 267901 agaagagaaa tcagctgagc tgacagcggt aaagcaggac aaaaacgcgg gctgaatgct 267961 gatgaggcag acaccgggtc tgcctctttt tttatgaaag ggagggcttt tttgaatgga 268021 taaaaaagaa acccatctga tcgggcattt agaagagctt cgccgccgga ttatcgtcac 268081 ccttgcggca ttttttctat ttctcatcac ggcttttttg ttcgtacagg acatttatga 268141 ctggctgatc agggatttgg atggaaagct ggctgtgcta ggaccgagtg aaatcctctg 268201 ggtgtatatg atgctttccg gcatttgtgc cattgcggct tctatccctg ttgccgcgta 268261 ccagctgtgg cgtttcgttg caccggcgct gactaaaacg gagcgcaagg tgacgctcat 268321 gtacatacca ggtttatttg cgttgttttt ggcgggcatc tccttcggat actttgtctt 268381 gtttccgatc gtgctcagct ttttgactca tttatcctcc ggccactttg aaacgatgtt 268441 tacggctgac cgctacttta ggtttatggt gaatttgagc ctgccgttcg gcttcttgtt 268501 tgagatgccc ttggtggtga tgtttttaac aaggctgggc atcttaaatc cttacagact 268561 ggccaaagcg agaaagcttt cctattttct gctgattgtc gtgtccatat tgattacacc 268621 gcctgatttt atttctgatt ttctcgtgat gatcccgctt cttgtcctgt ttgaagtgag 268681 tgtcacccta tcggcgtttg tctacaaaaa gaggatgagg gaagaaacag cggcggccgc 268741 ttagtgcagc gtaccacccg gtgacttcac atcctcatca tattgtgcgg ccgtaacagc 268801 ggcgattctc aatgcccgga caatcgtgtc caggctgagg ctcggcgctg ttttgtcgat 268861 tgtttgctgc ggaatgtaag gaatatgaat aaaaccgccg cgaatgtgtg gggatgtccg 268921 gctaatgtga tccattaacc cgtagaacaa atagttgcat acaaaggtcc ccgctgtgta 268981 ggaaaccgca gctggaatgc cgtgttcctt catcttagca gtcattcgtt tcacgggaag 269041 ccttgtccag taagcggcgg gcccatctgg agaaatctct tcatcaatcg gctgatgtcc 269101 ttcgttatcg gggattcgcg catctgcaag gttgattgcc actcgttccg gtgtaatctg 269161 catccgtcct cctgcttggc cgacacaaat tacgatatct ggctgatgtt tttgaatggc 269221 ttggcgcaga gtgtccagag cggatctaaa gacggttgga atttgttccg ctgtaataat 269281 ggcttcttct gtctcgaagc cattaagccg tttcgccgct tcccatgatg gattgacggt 269341 ttctttgtca aaagggtcaa agcctgtgat cagcactttt tttctcattc tcccatctcc 269401 tttttctttt attctattgt ttatttatgg gtttttcatc aaaataatgt aaaggagtga 269461 atcataatgg agcatttgcc ggagcagtat cgccagttat tcccaacctt gcagacgcat 269521 acgatgcttg ccagctgttc tcagagcgca ttggcagagc ctgtatcaag ggcgatccag 269581 gattattatg atagcctgct gtataaaggg acgaactgga aagaagcgat tgaaaaaaca 269641 gagtttgcga gaaacgagtt tgcaaagctg atcggggctg aaccggatga agtggcgatt 269701 gtgccgtcag tttctgatgc actggtttct gtagcatcgt ccttaactgc atttggaaag 269761 aagcacgttg tatatacaga tatggatttt ccggcggtgc ctcatgtttg gcaggcacac 269821 tccgattata ccgtatccgt cattccatca atagacggcg tgctgccgct tgaacaatat 269881 gaaacgcata tttcggatga aacagtactg acgtgtgttc ctcacgttca ttatcgtgac 269941 ggctatgttc aggatataaa agcgattgcc gagatttctc agagaaaggg ctctttattg 270001 tttgtagatg cttatcaatc agccgggcat attcccattg atgtgaagga atggggcgta 270061 gatatgctgg cagcaggcac ccggaagtat ttgctcggca taccgggtgt ggcgtttctt 270121 tatgtgagaa aggagctggc tgacgcactg aagccgaaag catcagcttg gttcggaaga 270181 gagagcggat ttgatggggc ttatgcaaaa gtcgcgcgcc gttttcaaac gggcacccca 270241 gcttttatca gcgtatacgc agctgcagcg gctttatcgc tgctgaatca tattggggtt 270301 tctcatatca gggatcatgt gaaaacgatc tgtgccgatg cagttcaata tgccgctgaa 270361 aaaggcctgc agctggcggc ggcacaaggt gggattcagc cgggcatggt tgcgatccgg 270421 gatgagcggg catcggaaac ggcggggttg ctgaagaaga aaaaagtgat ttgcgcgccg 270481 cgggaaaatg ttatccgtct cgctccccat ttttataata cgaaggagga aatgcggcac 270541 gcgattgatg aaatcgcggc gaaaacgatc cacaagtaaa catgaaaaag cccctgaaca 270601 ctagtcaggg gcttttcata ttaatgatct actttaacgc gtttcataaa gaaagcgcca 270661 attaaaccga taatggcaac aatcattgca aacacaaatg cgtgctgtac gcctgctgtc 270721 aaagcttgcg ggatgactgc cggatcggca gggtttttaa ctgtactcat ataatcatgc 270781 tggcctgcag ccataatgct gaccgcaacc gctgttccga tagcgccggc catttgctgc 270841 agcgtgttca taatggcggt gccgtctgga taaaattcac gcggcagttg gtttaaaccg 270901 tttgtctgtg caggcatcat gatcatagaa atcccgatca tcaagcaggt gtgcaggatg 270961 ataatcagca cagctgttga agtggtcgtg acatttgaga agaaccatag tacaacggtg 271021 acaatcacaa atcccggaat gacaagccat ttcggcccgt atttatcgaa caagcggcct 271081 gtaacagggg acataaatcc atttaaaata ccgcccggca agagaacaag accagatgca 271141 aatgcagtga ggactaagcc gccttgcaga tacatcggca gaagcagcat agatgacaga 271201 atgaccatca tacaaatgaa caccatgatc acacccaaaa taaacatcgg gtatttgaac 271261 gcacggaggt tcatcatagg ctgcttcatt gtcagctggc ggattgaaaa taagataagg 271321 ccgacaacgc cgacaatcag cgacacgata acagtcgggc tggaccatcc cccggagcct 271381 tcacccgcgt tgctgaatcc gaatacaatg ccgccgaagc caatcgtcga caggatgata 271441 gacaatacat cgattttcgg ctttgtcgtt tcagatacat tttgcatata tgcgataccg 271501 aaaacaagcg ccagcacaag gaatggaaga gagatccaga aaatccagtg ccagttgaga 271561 tgctccagaa ccaatcctga gaaagttggg ccgatggcgg gcgcgaacat aatgacaagc 271621 ccgatcgttc ccattgcggc accccgttta tgaggcggga aaatcaccaa gattgtgtta 271681 aacatcagcg gcagtaaaag accggttcca agtgcctgaa cgatccttgc cgctaataaa 271741 aacgagaagc tcggcgcaag cgccgcaatg aatgtaccta aaattgaaaa gataagtgac 271801 acggtaaaaa gctgtcttgt tgtgaaccac tgcaacagca gtcctgaaac aggaacaagg 271861 ataccgagta caagcaggta gcccgtcgtt aaccattgga cggttgccgc tgtaatgttc 271921 aattccttca taaggtcggt taacgcaata ttcagcgctg tttcactgaa catgccgata 271981 aaaccggcca acagcaagga aatcataatc ggcatcactt tgtattgctg agatgcttta 272041 gctgttgttt ccaaaatcat ttcccctctc tatcaactgc atgtagtatg tcgttttttt 272101 tatctcttca gcaggtcagg aatgcagctg gagatatgaa ggagcggcgt actgtttttt 272161 gccgtcaaag ataaaaggat gccgccttca atcatcgcgt taaccacagt gctggcttct 272221 tttgcacggc tctcgctgca gccagtctgc cgcagttttt cctcatacac agaggcccat 272281 tctttgtagg cttcatgaca ggcttcgcgc aacggttcgc ttttcaatga cgtctcagcc 272341 gctagcaagc ccacaggcaa gccttcaatg tcttccgtac atgaaaactg gcaggagagc 272401 tccttcaaaa aggcttgaat gccttccgct ggatcggtgc aggcttccat gcagtccgcg 272461 attttctgac ggatatactc cttcatctca ttcacggctt cgatcgcaag ctgttcttta 272521 cccccgggaa agtggtagta aagagagcct ttaggcgcgc cgctttcctt tataatctgg 272581 ttcagccccg tgccgtaata cccttgcagc tgaaaaagcc gggtagctgc cgaaaggatt 272641 ttctcacggg aatctccata actcataaca ttcccacctt actgaattgc aatcaaaaat 272701 atagtgactg gtctattatc ttgattcaat catcaattgt caagaaaaat tcattgtatg 272761 aaaagacaaa aaaagaagga tatgacaaca aaaaatactg agagaaaagc tgactgatct 272821 tttgactgaa tagataaaat gtacaatgat taatcatcat atggatgtaa ggagagaaat 272881 agatgaaaaa acaacgaatg ctcgtacttt ttaccgcact attgtttgtt tttaccggat 272941 gttcacattc tcctgaaaca aaagaatccc cgaaagaaaa agctcagaca caaaaagtct 273001 cttcggcttc tgcctctgaa aaaaaggatc tgccaaacat tagaatttta gcgacaggag 273061 gcacgatagc tggtgccgat caatcgaaaa cctcaacaac tgaatataaa gcaggtgttg 273121 tcggcgttga atcactgatc gaggcagttc cagaaatgaa ggacattgca aacgtcagcg 273181 gcgagcagat tgttaacgtc ggcagcacaa atattgataa taaaatattg ctgaagctgg 273241 cgaaacgcat caaccacttg ctcgcttcag atgatgtaga cggaatcgtc gtgactcatg 273301 gaacagatac attggaggaa accgcttatt ttttgaatct taccgtgaaa agtgataaac 273361 cggttgttat tgtcggttcg atgagacctt ccacagccat cagcgctgat gggccttcta 273421 acctgtacaa tgcagtgaaa gtggcaggtg cccctgaggc aaaagggaaa gggacgcttg 273481 ttgttcttaa cgaccggatt gcctcagccc gatatgtcac caaaacaaac acaactacaa 273541 cagatacatt taaatcagaa gaaatgggct tcgtcggaac aattgcagat gatatctatt 273601 ttaataatga gattacccgt aagcatacga aggacacgga tttctcggtt tctaatcttg 273661 atgagctgcc gcaggttgac attatctatg gataccaaaa tgacggaagc tacctgtttg 273721 acgctgctgt aaaagccgga gcaaagggga ttgtatttgc cggttctggg aacgggtctt 273781 tatctgatgc agccgaaaaa ggggcggaca gcgcagtcaa aaaaggcgtt acagtggtgc 273841 gctctacccg cacgggaaat ggtgtcgtca caccaaacca agactatgcg gaaaaggact 273901 tgctggcatc gaactcttta aacccccaaa aagcacggat gttgctgatg cttgcgctta 273961 ccaaaacaaa tgatcctcaa aaaatccaag cttatttcaa tgagtattga agaaaagaag 274021 gcgaataagc cttctttttt ttggcttttt aggaccaata atgacctctg aatcttaaaa 274081 tttctttaaa aataagccaa aattaccctt tacttaatta atttggtaac gtaatataat 274141 tggagaattt gttacaaaaa aaggaggata ttatgaaatt tgtaaaaaga aggatcattg 274201 cacttgtaac aattttgatg ctgtctgtta catcgctgtt tgcgttgcag ccgtcagcaa 274261 aagccgctga acacaatcca gtcgttatgg ttcacggtat tggaggggca tcattcaatt 274321 ttgcgggaat taagagctat ctcgtatctc agggctggtc gcgggacaag ctgtatgcag 274381 ttgatttttg ggacaagaca ggcacaaatt ataacaatgg accggtatta tcacgatttg 274441 tgcaaaaggt tttagatgaa acgggtgcga aaaaagtgga tattgtcgct cacagcatgg 274501 ggggcgcgaa cacactttac tacataaaaa atctggacgg cggaaataaa gttgcaaacg 274561 tcgtgacgct tggcggcgcg aaccgtttga cgacaggcaa ggcgcttccg ggaacagatc 274621 caaatcaaaa gattttatac acatccattt acagcagtgc cgatatgatt gtcatgaatt 274681 acttatcaag attagatggt gctagaaacg ttcaaatcca tggcgttgga cacatcggcc 274741 ttctgtacag cagccaagtc aacagcctga ttaaagaagg gctgaacggc gggggccaga 274801 atacgaatta atgaaaaaca aaaccttgaa gaatgctatt cttcaaggtt attctgcttt 274861 cagcacaatg gttttcgcag ccatatcatg aacggtttgt tttttcttcg taaatgcggc 274921 agtcaaatag atcaggcggg agaacacatg cacccacgct atcaggtaac ggacaatggc 274981 ttgcgggaag gatatttttt tatatgtttc gtccctcacg atttgcagcc cgatgatttt 275041 tttgcccagt gtgcccttcc aatttgtcag cggcatcagc aaagggtaca caatcagcat 275101 caatatggcg acaataatga caccggcgga cccatcgcca aacgtaaatc cggctgccaa 275161 aatcactgct gcggcaatga ttacatcaag taaaagagcg caggcgcgca gcatgaaacc 275221 agctagttcc aatagaaaca ctccttaaaa tgttaaataa acacctaatg attgtaaaaa 275281 agaagggcct aaagtgggaa taggtgataa gccttaaatc acaaaagttg gtgaaaatgt 275341 cataggtaaa ttggcataat cagccagctt atcacattac caaattcttt tttagcccga 275401 aaccaagccc tcagaagtta tttttgttaa aatagaaaag ttacaacaga attcggaggg 275461 tttattgtgg gaaaagtgaa acgaaatgcc ccttgcccat gcggcagcgg caagaaatat 275521 aaaaaatgct gcggaagtaa agttgtcgac ttcccggcgg aactagcggc aaaagaagcg 275581 aaacaaattc aggaagactt agtggagtat gccttcacag tacatagaga aagcatttca 275641 ggctttatca accagcatga ttttctttct gctatggaca gacagacgaa agacatcagc 275701 gtatttaact taggaatctg gggaatcttc ttccacccgc ttgctggtga gaagacaatc 275761 ttcgaagagt accttcagaa aaaaggcgat tcgatcactc gtccgaaaac gcgtgagatc 275821 gtagaatcat ggcagagcat gacgcctgct ttattgctgc tgaaggacct gaaggaaggc 275881 atcattcact ttgaagatgt cattacggca aaacaattcg aagtggaaat ggacgccagc 275941 aatcaagacc ttcctccagt gggaagcctg attcttggat acccaatcca cgaagcggaa 276001 aaagcagaat tcttcatgca gttcacgatc ttcccggtga agagaacaga agcgctgatc 276061 agcaaggtga agaaatatgc ggatgccgct gtgaaggacg gcaaaacgcc ggaggacttc 276121 atgaagcagg aattcaacaa cgttctgttc gcgttgttag ctgagaaaga tgaagagcca 276181 caagcagaga aagcggaagt aagcactgtt gagtgggcaa acgacttgga gaaagaaacc 276241 gctgcggcta ttgaagaagg catgagcggg gaagagtatc cgactgaatt gatcccagct 276301 gttattgaca tctggaaaac attctgcgag aaaaaatcac ctgtcatcag aaagccggaa 276361 gcttttgcgg cggcagttga atattatgta aacgcaattt ctcttaacgg cgcgtccgtt 276421 tcccaggcta aactggcgaa aaaatacggc gttagcgcat caacgatttc cagccgttac 276481 aaagaaattg aaagcacgct gcaagatgaa gcagatcgtt ttgcacaagc gttatcctca 276541 taatggaaaa aaccttgaaa agccaggctt ttcaaggttt ttttatttct gaaacggaat 276601 tttgatttct aaccggaaga tggggtggcg gtaggtaaaa tccagcctgc caaaagcgcc 276661 cttcaccagt ttttgaatga tatatgtgcc catgccttca tgagcgccgt ttttcgttga 276721 gcggccaaac gattgataaa ttgtatcgag cacttttggg tccatcccgg gagtgctgtt 276781 ttcacaagtc agtacataaa gcccgctgcg cagtgaagtc tccagtttaa tctctgcttt 276841 ttctcgggcc tccgccgcgc tgtcgagcgc attttctaat atgttgccga ccaagctgac 276901 ctgatcagca ggcgaaaacg gaagggaaga aagcggtgta tgcatatgca gcgaaacact 276961 cacattcgag gcgcgggctt tttctaaaaa atcataaagc acccctgcaa cgtacgcgtt 277021 ctctcctttc aaaaaacggt catattggct gtattgatcc gcccagtttt gaatatatgc 277081 ttgtgtatct gccttgggct gagctgattt gattgcagtg atatgtttca ttgtgtcatg 277141 attccggctt ctgacatcaa tcagcatttg attggcgtgc tgttcagctt gagtcagctt 277201 atcaatttga tcagaaagcc ttgcctgcaa agcagactgt ccgatacgga gcccttcaca 277261 ccctgcaaat atcgcgatta cacataatac cggcatgatg tctgtgccaa tcaacaccac 277321 tcccaccgac atcacttgaa tcaccgcaat ccacgcacaa agccctgagg aacagtgttt 277381 ccacacccgc ttcgtattcc aaatgtacaa tcctgcagca gctgcgccta aagcagcggc 277441 gagccaagag gcggctgtgc tgtgtgaaaa agcagcagct ccctgataac atatgaaact 277501 aaataaaatc agataaagac attgaaaaag ggtaatcacg tactaaactc ctcaaaaata 277561 gtagttttga aaataatcaa gctgctgctt agtgatcatc gcttttttag acgttccctc 277621 aaaggaaact gtgaatgaat gcttggtata agcggaaaaa tgctttatgt aatgaatgtt 277681 gataataaag gaacgatgcg aacgaagaaa atctttttcg ggcaggtcgc ctttaatatc 277741 atttaatgtt tgatacgttt gcacctcttc ggcggttgtc acaatcgtcg tcgaacgtcc 277801 cgtccgttct gcgaaaataa tatccttctt ttgcaggacg tgcatttcag acttttgctt 277861 tatcaatata cgcccattca aactcgtttc cgttttcttt ttcaagtacc ggtcgaagga 277921 agcggccaga cggtcggcat agtacggctt cataatataa tcatggacgt tcaggtcaaa 277981 ggcgtgaacc gcataaccgc cgtggccggt aacaaaaatc acatccacat caagtgaatg 278041 ggatttgatc aaatcagcaa gctcgtagcc agacatatgg ggcatctcga tatcggcaag 278101 cagcagatca atgtctccgt tctttacccg cctgtaggct tccttcgctg aatcggtgga 278161 aaagacaatt tcgacgtcct gcattctgga cacgatcgct tctaacttct ctaaatctac 278221 tcgataatca tctacaagtc cgacttttac cattatcatt cccctagtta catagaatca 278281 tctttattct atcccatttc acgacataaa aagaactctt cgcgacaact ttatccaact 278341 aatccagctt ttcgtatata gtcattacta gaaataaaga taagggagat tgtgacatga 278401 ttacactgac cgattgcagc cgcaggtttc aggataagaa aaaagtagtc aaagcggtgc 278461 gagatgtaag cttaacaatt gaaaaaggag aagtcgtcgg cattctcgga gaaaacggtg 278521 ccggcaaaac gacgatgctg agaatgattg cttccttgct tgaaccatca cagggtgtaa 278581 tcacagtaga cggctttgac acggtcaagc agccggctga ggtcaaacaa agaatcggtg 278641 tcttattcgg aggagaaacc gggctttacg acaggatgac cgctaaagaa aatctccaat 278701 acttcggcag gctgtatggg ctgaaccgcc acgagatcaa agcaagaata gaagatttat 278761 cgaaacggtt cggcatgcgc gattatatga accggagagt gggcgggttt tcgaaaggca 278821 tgaggcagaa agtcgccatt gccagagcgc tgattcacga tccggacatc attttatttg 278881 atgagccgac aactgggctt gatattacgt caagcaacat cttccgcgaa tttatacagc 278941 agctgaaaag agaacaaaaa acgattcttt tctccagcca cattatggag gaagtgcagg 279001 cgctctgtga cagtgtcatc atgattcaca gcggagaggt gatttaccga ggggcgcttg 279061 aatcactata cgagagcgag cgcagtgagg atttgaatta catctttatg tctaagcttg 279121 tcagggggat ttcttaaatg ctgagccata tttataaaaa agaaatgatc gacgctttac 279181 gcgacagaaa aacgatatta ctcacaatct tagtgccgat gattatgatg cttggacttg 279241 tcttttttta tgaaagcatg ctgtccgaca aaggggagca gtacacgctg gctgtcggcc 279301 attcgcttcc gcccgcactg gaaagcaagc ttaatgagat tgacgaaatc agcgtaaaaa 279361 catttgcaaa gcctgaagag gcagttgatg aaggaaaagc agatgcctat ctgaacgtcc 279421 cgaaagagtt cgactcatat gtcaacagca tgacaccttt taaggttgat gtttacggca 279481 attcaatcga tcaagggtcg tcaaatgcca tgcagcttgt gcagtctgcc ttagatcagt 279541 acaaaaatga aattgtgcag caacgtttaa caaataagca tattgatcaa tcggtgatcc 279601 agccgtttac aattcagcaa aaggaagcgg atgaggagaa agggacttcc gctattatgc 279661 tttccgccat tctgcccatg ctgattctga cttccattgt ttccggcgca atgccgatcg 279721 ctcttgatat catggccggt gaaaaggacc gaaagtcaat cgaggcgctg ctattaacgc 279781 cagtcagcag aaacaaagtg ctggtcggca agtggcttgc ggtttccact tttggcgtgg 279841 cttcaggtgt atttgctttg gtgtttttga ttttgtccac cgtgttattt accgaaaatt 279901 taaaaacggc cttccagctg ggagatcata tgtggagtgt aatcggcgct tcagccttaa 279961 tcattgtgct ctctgcattg ctgatatctg cgatggagct tttcatcagc atcatgtcca 280021 gctcggtaaa agaagcgcaa agttatatgt ctctcgtcgt ctttctgcct gtgttcccga 280081 tgtttttcat cttcagcaag gcaccgaacc aatttgactt atcatacttt ctcatcccgt 280141 ttctgaacct gcatgcgtta tttaaacagc ttttattcgg gatggttgac ccggctacca 280201 ttttgtctac gtcaggaacc atcgccgtgc tcatcgccat cttcttttta ctagccagag 280261 cctgcttcct gaaagacaaa tgggttcttc caaaataaac ttgcgaaagg agaaatacac 280321 tttctccttt ttgtatatcc tgaaaaaaga aggaaaatag aaaaaggata tctaatacaa 280381 aaagtgaccc tgcactattt ttcatcaaaa ttggtttcaa aggagaagga acaatggatc 280441 aaacacgtac actcggcaaa acgaagctga aggtgaagcg gatcggattc ggcgcgaatg 280501 cggtcggcgg gcataatcta tttccaaatc taaatgatga aacagggaag gatttagtgc 280561 gcacggcatt ggatggcggc gtcaatttta tcgataccgc ctttatatat ggattggggc 280621 gatctgaaga attaatcggc gaagtcgtac aggaacgcgg cgtgcggaat gagctcatca 280681 tcgccaccaa aggagctcat aaagaagtgg acggcagcat tgaattagac aatagccggg 280741 agtttcttcg cagcgaggtg gagaagagcc tgaagcggct gaaaacagat tacattgatt 280801 tgtattatgt tcactttccg gatggaaaaa cacctctcgc tgaagtggcg ggcactttga 280861 aagagctgaa ggatgagggg aaaatcaaag cgatcggcgc ttcgaacctc gattatcagc 280921 aattgcagga ttttaatgct gacggctatt tggaggtctt ccaggccgaa tattctctca 280981 tacagcgtga tgccgagaaa gagcttcttc catactgtga aaaacaaggc atctccttta 281041 ttccttactt tccgcttgcg tccggactgc tgacaggaaa attcacgcaa gacacagtct 281101 ttgatgattt cagaaaggat aaacctcaat ttcagggtga aacgtttatc cacaatctca 281161 aaaaagtaga taagctgaaa gcagtagcgg aggaaaaaca agcggatacg gcacatgtcg 281221 ccttggcgtg gctgttaacg agaccggcga ttgatgccat tattccagga gctaaacgac 281281 cggagcaatt acaggataac ctgaaaacct tgaacattga actgaccgaa gatgaagtga 281341 atttcatcag cgacattttc aaataaaaaa ggaaatagcc gtcatggcta tttccttttg 281401 gtgttttatt ctttgatgaa tgcttcgact aattctgctg ctctgtaatc atccatatca 281461 agctgccatt ggtcgatgtc atttttcttc attttcactt caactgtttt ttcagatgaa 281521 gcaggtccaa gctttttgaa ttcctcagga tagacttgaa gcgcgtattt cactgcctct 281581 tcatagctgg cactagagtt tttactgtag tagtctttca ctttgtcttc gatgcggtct 281641 gaaagagaag atgcatctac aggtttaact gtggcttcaa caattgcttc gtctttagag 281701 attgaagtcg tttttgcttg aatggaagag tttttgctta atccctcttt aatgccgttc 281761 acgatattat caagcgcttt gctgtccgca tatgtgctgg aaaggccgga agctgagaga 281821 taaccgtctt tggctgattc attaaaatca tttacaattt catttttgtt agcgccggtg 281881 attttttcga aatcggcgtt atctttgccg aaaagaagga catcaacata agctgataac 281941 gcttttgcag aatcttggag cttatctgcc gtcgccagga tttttttgtc ttttccgtca 282001 attttaaaag taactgattt tggcttttta tcaccgtaag attccggcgt atagttaagc 282061 tcgtattgct tgcctttatc tacaacgaag aaaagatttc cttcaacgga tttgtcagcg 282121 ttaatcgtgc tgccctgaag cttttcgcta tagtcttcag ggtctgtgtc agacattttg 282181 gtatcacctt gatacaatgt gaaatccata ctgtctacat tcagcgggtc ttttcctgtg 282241 tttttcaccg cgacattgac ttttaacaca agctggtcat ctgaagtgga cttatcatat 282301 ttagacggaa gtgtgtaaga gacatccttg attttgactt gagctatatc tgagcttttt 282361 tctgtttctg attctttctt ctccgcgctt gttttgctgc cggaacaagc agctgtaaac 282421 atcatcagca gaagaattag gaaaacagcg tacgtttttt tctgaaacat tcatttttcc 282481 tcctcaaatg gtttaggaaa ggggagtctt ttgtctttga gaaatggatc tttttgaatg 282541 gattagcatc atataaccaa aaaaatcagt tcttttctca cggttttcac cggattttct 282601 ggaaactccg ccctcctttg tcatgaatgg acctataaaa agttacaacg gaattaattt 282661 taagattatt agcttttata ttgaataggt tcatcatcct atttttggtg aaaaatgttc 282721 tggtaaaact ggtaaactca gaaaactgtg tattttagac tattactttt tgattagttg 282781 gagggaactt aagaaggatg aaaggggccg cctttgtgaa gaaagaggga ctgaaacaaa 282841 aagcactgga aatcggccgg gtgccgacac acttaaaact ggaaattgaa gattatggcg 282901 gtgatgataa aagagctcat ttttgttggg cagatcctca ggatgagaat accggcatta 282961 tcgtggagct tggaccggac ggagagctgg aatccctttc ccgtgatatt gagcctgaaa 283021 gcggagaaag gctgtctgag gagaaactag aggatatcat gcgccaattt gtcgagactc 283081 atcatccggg ggcactctct gcctttgttc gtgaagaaaa tgaccgtgca tacggcgata 283141 aagtgagatt ttcatatgtt caaatggagg ctgggcttcc tctccccatg agcggattta 283201 tggctgatgt ttccttatca ggtgagattg tttacttccg ttattacggc gaagcgggca 283261 gcatcatcaa gccaaagcgg gtcgcggatg ttgaagaggc acttgccttt atcaagaagg 283321 acgtggagtt cgaccttttg tttgaggttc tccatcgttc tgtttacaaa aacggagatg 283381 atcagccgca tttggtgtac gagcctgaag gtagggcgat taccgtacct gcggatttgg 283441 ttcaagaaga acaagcagtt gatgatgacg atgattacag ggagccggag agctttcctc 283501 tccctttatt cgagggcatc cgcgaaaagg ccgatcctga cagcatgatt ggtattgaaa 283561 atgggtttgt caaagagcgg gaagcggatt tgggagatgg gagaattgga atcgtttggc 283621 ggaatccgga tgaccctgtg tatcagccgg cggataaaag catggacagc tggtttaagg 283681 gacggactca tcaagtgctg aaaaccatct ataacaaaga aaccggaaaa ctcgaaggcg 283741 tcatgtcatt tatggagaaa aaagggccgc tgacagtaac cttggcagag tgtgaaaaaa 283801 tcgcgcttcg ctttctattt gctttatttc cgaatgccga tcaatatttt aggatcagat 283861 acgacgaaaa agatgaagaa gaaaacgcag tcgctggttt tacgtttgaa gcgcattgtc 283921 acggagttcc gctccgattt gggcagatca gaatttgtgt cagccgccag acagggtata 283981 tcaccgttta tatgggaccg gatattgacc caaataagct ggcaaccatt gatcctgtgc 284041 cggctatttc agttgaacaa gccaagtcta tcttttggca gcattttaaa gttgagcttg 284101 gctgggaaag agagtacggg gatgatgaag aacacagcta ccggctcgtc tataagccgg 284161 tgtatccgca ttttatcgat gcacatacag gggagcctgt cttcagcata tggtgaaaca 284221 gccaaaagtc acgcaattgc ctcagatata gaagagagta tgtgatgaaa gtaacagaaa 284281 gaatctcaaa aaacaatgac aataatagaa aaggaccttt cttcacttta aatgaagaaa 284341 ggtcttttta tataataaac aggattctct ttgtcgtaga ctctttgaaa gggatgactt 284401 cattggttaa taaacagctg aaaaagaagg cgcaggagat cggaaatgta ccgacgcatt 284461 atgagcttga gatagaagat tacgaccaaa agcaaaagaa gtacgggcag gcatatttta 284521 tctggaagga ccctaaagat ccggaaaagc acattacagt tgaacttaga aatgacggcg 284581 ccttgctcac cttttcaaca actgtccact ccgagacaga caaaaaactt ccagatgccg 284641 agctgaagct gacggctctt cagtttgccg ctgccaatca tcccggcaca tttatgaatt 284701 ttcattttca aggcaaggaa gaaagggggc agcacatccg gtttgtctat accaaaatgg 284761 agctggggct tccgattccc aattcaggct ttttaattga tatgacacga agcggtcaga 284821 ttgtccactt tctatattac ggggaagggc ataaagccga agttccgacg gaatttgtag 284881 caaaagagaa ggttgtatcc cattacttaa acacaatgtc ttttgagctg atgtacgatg 284941 tcattgatgg cgaacaggaa ccaaggcttg tatatgaacc gattctaccg ggatacagct 285001 atcccgcaga tgtagacgaa attgtgcccg accagcatat cgcagatgaa agaatagaaa 285061 acacggcgcc actgccgccg cttcagaaca aggaagaagt tgatatattt gccttgctgg 285121 gttttacctc tgatatgcag aaagtcagtg aaagagactt tggagaacaa attggaagca 285181 cgtggcgcag gggcgctgcg ccggagcgta aggatttaag cataggaagc tattttgaaa 285241 cgagaaataa aaatacaatc aaaatgaaga cggataaaag aaccggaaaa ttaaaagcag 285301 cgctttcttt tatggactgg cggaacaacc tccaatgctc cacggaagaa tgccaagaga 285361 tagcgcttca atttttgtat gccctctatc cgagagcggc tgagtttttc agggtgaatc 285421 ccgtccgaat tgatgaaaga gggagagtcc gcaaccattt ttctgtctgg tataaaggag 285481 tgccgctgcg gttcggcgct gcccgcatca ttgtcaatcc ggaaactggg ttgattgacg 285541 cttttatggc gcctgatatt gaacctgaac aattggaagc gataaatcac aggccggatg 285601 tttccgctga agaagcgaaa gaagcatttt tagccgcttt tgatgtgaaa ctggaatggc 285661 agcctgattt tacagcaggc agtgaccagc actgcaaact tgtctataag ccggtttacc 285721 cttcctatat tgatgcgcac ataaggaaaa agaaaaggct gtgaggggtg tctagttagg 285781 aatcatctcc aagtgggggt agtccttgaa tcgtttccaa tccccgcccc attcgaaacc 285841 gagtgtctta gcgatctcga caacctccag ccaatctgat tttccgtttt gattgccgtc 285901 atattccata tcccatatga tgctgccatc ctttttttga agggcgaaat caatcgctaa 285961 accatagtta tgatacgatt cccctcctct tgcataggtg acaatattcc ctttttttgt 286021 acgtccctgt ttatataatt catcttgttc cttaaaggac ctgaatcctt cagtaatgac 286081 gacgtcaatg cctttattcg ctgcagcggc tttgagtgca tcggcattct gcttcacaat 286141 cggatgaaga tccgagggga caggcatgtc ctgcaaggcg ttttgagaat gccattcatg 286201 ccgaatataa ctaaaacaaa gatctagaag aaatagaata cataagataa caaatgtttt 286261 tgcgggtaag ttcatatcgg tctcactttc tcaagatgtg ctgaatgtta acgcttttaa 286321 gtgattgact ctctctaaaa gcgaacagct atgataaaat ataacataaa tagtagcagg 286381 aggaaggagg cagaccgatg agagcaaaga ttccatcaga agaagtagca gtaaagctga 286441 atgaatggta caagctcatt cgcgcatttg aagcagatca agcagaagcg ttaaagcagg 286501 agattgaata tgatttagaa gatatggaag agaatcagga cttgctttta tatttttctt 286561 tgatggaatt ccggcatcga atcatgcttg ataagctgat gccggtgaaa gacagcgata 286621 ccaagcctcc gttctctgat atgctgaacg aaattgaaag caatcagcaa aaactcacgg 286681 gcttactgga atactacttt tattatttca gaggaatgta cgaattcaag cagaaaaatt 286741 tcatattagc gattgaccat tataaacatg ccgaggaaaa gctcgagtat gtcgaggatg 286801 agatcgaaaa agctgagttt ctttttaaag tcgcagaagt gtattatcac atcaaacaaa 286861 cgtatttttc catgaattat gcgagccagg cgcttgatat ctatacgaaa tatgaactgt 286921 acggtcgccg ccgggttcag tgtgaattta tcatcgccgg aaatttgacc gatgtgtatc 286981 atcatgaaaa agcactgacc cacttgtgca gcgctttaga acatgccagg cagcttgaag 287041 aagcgtacat gatcgctgct gcctattata atgtcggaca ctgtaagtac agtctgggtg 287101 attacaaaga agcggagggc tatttcaaaa cagccgccgc catttttgag gagcacaact 287161 ttcagcaagc tgttcaagct gtattttcac tgacccatat ctactgtaaa gagggaaaat 287221 acgacaaggc agtagaggct tatgaccgcg ggataaagag cgcggctgaa tgggaggatg 287281 acatgtactt gacgaaattc cgcctcattc atgagctgta tcttggaagc ggcgacctga 287341 acgtgcttac agaatgcttt gacctgctgg aatccaggca gcttcttgct gacgccgaag 287401 atctgctgca tgatacagcg gaacgtttca atcagttgga acattacgag tccgccgctt 287461 tcttttaccg caggctgatg aatattaaaa agaagcttgc cgagcagcgt tttcaatagg 287521 aaatggcaga gaactacagg ttctctgctt tttttgtgct gttttcaact cggaaaaaca 287581 gggtattttc cactgcatag tgagaaacag aggaggatat caagtatgta caaagattta 287641 accggaaaaa cagcgattgt gacagggtct tcaaaaggaa tcgggaaagc cattgcggaa 287701 cggttcggaa aggagaaaat gaatgttgtt gtaaattacc acagcgaccc gtctggagca 287761 gatgaaactc tggaaatcat taagcagaac ggagggaaag ccgtctcagt tgaggcggac 287821 gtgtcaaaag aagaggggat tcaggcgctc ttggacacag ctttagagca tttcggcacg 287881 ctcgatgtga tggtaaacaa ctccggtttt aacggcgttg aggcgatgcc gcatgagatg 287941 agtcttgaag attggcagag agtgattgat gtcaatgtta ccggaacctt tctgggagcg 288001 aaagcagcac ttaaccacat gatgaaaaac aatatcaagg gcaatgtgct gaatatctca 288061 agtgttcatc agcagattcc gcgccctgta aacgttcagt attccacatc caaaggcggc 288121 atcaagatga tgacggaaac gctggcgctc aattatgcgg ataagggaat ccgcgtcaat 288181 gcgatagcgc ccggcaccat tgccacagaa tcaaatgttg atacgaaaaa ggaagagagc 288241 aggcaaaaac aattgaaaaa aatcccgatg aaagccttcg gaaagcctga agaagtggcg 288301 gcagcagcag cttggctcgt atctgaggaa gcaagctatg tgaccggcgc aacacttttc 288361 gtcgacggcg gaatgacact ttatccatct cagcttgaat agaagacaaa acagggggat 288421 tgcgggatga aaacagactg gtggaaggat gcagtggtgt accaaattta cccgagaagc 288481 tttcaggaca gcaatggaga cggaattggg gacttgcggg ggattatttc ccgtcttgac 288541 tacataaagg agctcggggc agatgtgatt tggatttgcc cgatctatcc ttctccgaat 288601 gttgattacg gctatgatgt gacaaaccat aaggcgatta tggattctta cggaacaatg 288661 gacgattttc acgagctgct ggaccaggtg catcagcggg gattaaagct ggtgatggac 288721 tttgtgttaa atcacacctc ggtcgagcat ccgtggttta aagaagcgga gctggacaaa 288781 aacagcaaat accgtagcta ttattattgg cgtcccggca caaagaacgg cccgccgacg 288841 gactggctct caaactatgg atgcccggtc tggcaatacg aagagcacac cggagaatac 288901 tatctccata tgaatgccgt caaacaagct gatttaaact gggaaaatcc cgaagttcgc 288961 caggcggtgt atgacatgat gaaattttgg ctcgataaag gggtcgacgg tttgcgaatt 289021 gatcagctcc atctcatttc taagaaagaa tatcttcctt cgtatgagga ctatatcaat 289081 cagcaggcag agccgaagcc ctttcagcca aatggcgaac gaatccatga ctatttaaaa 289141 gaaatcacag atgaagtgtt ttctcattat gatgtcatgt ctgtcggaga ggtcggcagt 289201 gtcacaccgg aagaaggcct gaaatatacg ggaacagata agcatgagct gaatatgatt 289261 tttcactttc agcatatgga gcttgatcag cagcccggaa aagaacattg ggatttgaag 289321 ccccttgagc tttctgattt aaaatcggtt ttgacaaaat ggcaaaagaa gcttgaacat 289381 caaggctgga atacattgtt ttggtgcaac cacgaccagc cccggattgt gtccagattc 289441 ggagacgatg gggaataccg caaagcatca gcgaaaatgc tggcagccgt aatttatttt 289501 atgaagggca cgccgtatat ttatcaggga gaagaaatcg ggatgacaaa cgcgccgttc 289561 acccggattg aagactacaa agatatccaa acgatcaata tgtatcataa acgggtgttt 289621 gaaaaaggct atgatccaaa tgatgtgatg agatcgatct tagccaaaag ccgggatcac 289681 gcccggaccc cgatgcagtg gaacagcggc aaaaatgccg gatttactga cggcacgcct 289741 tggctgaagg tcaatccgaa cttcaccgca atcaatgtgg aggaagcgca gggagatcct 289801 gattctgtct taaactatta caaaaagctg atcagcctga gaaagcagta cgctgacctc 289861 atgaaaggga gctttgatct tttgcttccg gacgatccgc agttgtttgt atacatgaga 289921 gaaaacagta aacaacagct tttgtcggtc aataattttt caaaagagca ggctgttttt 289981 cagtggccta agaactgcgg caaagctcag gcctcactgc ttctcagcaa ttataacaac 290041 gatgatcttg atgacgaaat ggtgttccgg ccttatgaga gcagggtcta tcttctggac 290101 aaaacaaact aatgattgaa gtagcccggc atttttagcc gggttttttt agtacatata 290161 ttcgctctgc aggcgggaag aataaatgaa aatgaaattt attcttgcaa aacgtaatga 290221 cttcggttta ttatgatata ggattacaaa atcgttatca ttttgattta aagttactga 290281 aaaagagggg atatacgata tgtttaaaaa atggagcggt ttgtttgtga ttgcagcgtg 290341 ctttttatta gttgcagcat gcggcaactc atcaacaaaa gggtcggcgg attcaaaggg 290401 tgataaactg cacgttgtca caacgttcta cccgatgtat gaattcacaa aacaaattgt 290461 aaaagacaaa ggcgatgtgg atctgttaat cccatcttcc gttgaaccgc atgattggga 290521 accgacgccg aaagacattg ccaacattca ggatgctgat ttgttcgttt ataatagtga 290581 atacatggag acatgggttc cgtcagctga aaaaagcatg ggccaaggcc atgccgtttt 290641 cgttaatgca agcaaaggca ttgatttaat ggaaggctct gaagaagaac acgaagagca 290701 tgatcatggg gagcatgagc acagtcatgc aatggaccct cacgtatggc ttagccctgt 290761 tctggcacag aaggaagtta aaaatattac ggctcaaatc gtgaagcagg acccggataa 290821 caaagaatac tatgagaaaa atagtaaaga atatattgca aaactgcagg atcttgataa 290881 actatatcgt acaaccgcaa aaaaagcgga gaaaaaagaa tttatcacgc agcatacagc 290941 ttttggctat ctggcaaaag aatacggctt gaagcaggtt ccgattgcag ggctttcacc 291001 tgaccaagaa ccgagcgcag ccagcttggc aaagctgaaa acatatgcca aagaacataa 291061 tgtaaaagtt atttactttg aagaaattgc atcctcaaag gtcgcagata cgctcgccag 291121 tgaaatcggc gcgaagacag aagtgctgaa tacactggaa ggcttgagca aagaagaaca 291181 ggataaaggt ttagggtata tcgacattat gaaacaaaac ctcgatgccc tgaaagattc 291241 actattggtt aaatcataag atagtgtgcg ccggaggggt gcacactatt tctttgtgag 291301 aaaggaagat taacatgaat ctcgtctcat tgaaagatat cgttttcggc tattcccata 291361 cgcctgtttt agataaagta tcacttgata ttgaaagcgg tgagttcgtc ggcatcactg 291421 gaccaaacgg cgcctctaaa tcgacgctca taaaggtaat gctcggcatg ctgaaaccgt 291481 gggaaggcac agtgacgatc agtaaaagga atacagaagg gaaacgcctg accatagggt 291541 acgtcccgca gcaaatttct tcatttaatg ccggatttcc gagcacggtg ctggagcttg 291601 ttcagtcagg ccgctataca aaagggaaat ggtttaaacg tttaaatgaa gaagatcatc 291661 ttgaagtaga aaaagcattg aaaatggtgg aaatgtggga cctccgccat cgtaaaatcg 291721 gtgatttatc aggcggacag aaacagaaaa tctgtatcgc cagaatgctc gccagcaacc 291781 cggatctgct gatgctggac gaaccgacga cagctgttga ttacgacagc agaaaaggat 291841 tttacgaatt tatgcatcat ctcgtgaaaa atcacaaccg cacagttgtg atggttactc 291901 acgaacaaaa cgaagtacag caatttttag ataaagtgat tcgattagag agaggagaaa 291961 aaggcggatg gaaatgtttg acttggaatt catgcgacga gcttttctag caggcggcat 292021 gatcgccgtc atggctccga tactaggagt gtatctcgtt ctcagaagac aggccttaat 292081 ggctgacaca ctttcacata tctcattgtc aggtgttgcc atcggctttt ttctcagcac 292141 caatataacc gcagcaagca tagtcgtcgt gaccatcggc gcgatcggaa ttgaatacat 292201 gcggcgggcg tatcggactt attcagaagt gtccattgcc atcttaatgg cagctggttt 292261 gtccttcgcg atgtttttaa tcagcctttc caaaggcaca gccaatatga gcatcgatca 292321 atacctattt ggatcgcttg tgacagtaaa ccagcagcag gtctatatta tcagtattat 292381 cacactgctg atcctgcttt attttattgt actgagaagg ccgctctacc tgctgacgtt 292441 tgatgaagct acagccaaaa catcgggaat caatacaaac gttctctcgt tgtcattcag 292501 tattgtcaca ggccttgcga tttcagtcat tattccgatc atcggggtcc ttcttgtatc 292561 ggccctgctc gtattgccgg cagccttcgc catcagaatt gcaaaaggct ttaacatggt 292621 tttcattaca gccatactca tttcattatt cagcgtattt acgggactga catcatccta 292681 tcagctcggg acgccgccag gtccgtctat taccctgcta ttgatcgttt tgctattaat 292741 cggatttgca gttcagggag tttggacgtt tatcaaaaaa gaagctcagc gcaaaaaaag 292801 aagccgataa catgaaaagc agttttccct agggaaaact gcttttttta tagaaacaat 292861 tcggcaaggc gctcataaga ttcttttttc gcctcaaaat caaacacatt gcacagaacc 292921 atgatttcat ttgtttcgta gcagcctgtg aggtctaaca gctgttgttt gacagtggtg 292981 ggagaaccga tcaccatccg ctttctgttt tcttctatga gttttttatc ggacgctgta 293041 tagggatgag ctttcgcttc ctcgatgctt ggcacgcggc tgtccaagcc ttttccgacg 293101 cgaagaagcc acagatcctg gcttaatgcg agttcttctg cctcttcatc tgtttttgcg 293161 caaatgacaa aaatcgtaaa cagtgcggat ggattcgaaa aatgggctga gggccgaaag 293221 ctttcccggt agatgcggaa tgcattttct cctcgctcgg gattaatgaa atgcccaaat 293281 acatatccaa tcccctggtg cgccgcgcgt cttgcgctgt tttcaccaag accgagcacc 293341 catagctcgg gtgccgtacc aataaggggc gccgctttga ttccggcata cggatggtcg 293401 ggaggaaggg aatctgttag aaaataagag acatcctgca gctgtctgtt aaattcggtt 293461 aagctttttt tcaccccgtc cgttaatgca agtctggttt ttgtcgtgcc gccgggggag 293521 cgaccgacgc cgaggtcaat ccggtttgga tacagggcct caagctggcg aaaggtttca 293581 gccactttaa atgggctgta ttggggcaga agcacgccgc ctgatccgac acgaatggtg 293641 tttgtctgtg ctgcgatgcg ggcgatcatg atttcaggcg ctgtgcttgc cagtcctttc 293701 gtgctgtgat gctcggcaaa ccaataacgc ttatagcccc actgttcgct taattgggca 293761 agctcaaccg aatgctggag agttgtcaca gggctttctc ctttagaaac aggtgcctga 293821 tcaagtatgc ttaaatgaat caaaaggccg cttcctttct gtctgttttt agatggtgac 293881 accagaatag gcaaaatgac ttgcccgcgt caaatggttt gtttaagaag cgcactttat 293941 agcatttgca aatcatatat caaatatgga agtttttttt cgaggttttt cgtcaattat 294001 tcttaacttt tacgaaactt tgatataata acaaacgtat atattagtaa tttacggctt 294061 attttccttg tgagcgtaaa aataaatgtg actatcttca cattttgatg agtaggagtg 294121 aatcgtgtgg caatttcttt agaaaaaggt caacgaattg atttaacaaa aggaaaagcc 294181 ggtctgtcaa aattgatggt cggtctcggc tgggacccag tgtcctcagg cggaggattc 294241 ttcagcaaac tgcttggcgg aggcggtccg aatatcgact gtgacgcttc agtgctgatg 294301 ctggaaaacg gaaaattcac cgataagaaa aacctgattt atttcggcaa cctgaaaagc 294361 cgctgcggcg gtgtacagca tacaggcgac aacctgacgg gtgacggtgc gggcgatgac 294421 gagcaaatta tgatagattt agataaagtg cctggaaaca tcgataagct tgtatttgta 294481 gtgaacattt acgattgtgt cagaagaaaa caagatttcg gcatgattca aaatgcgttt 294541 atccgcgtag ttgatcaatc taatcacgag gaaatgctca agtacaattt gagagacaat 294601 tacgccggca gaacaagcct gattacagca gaaatctacc gcagcggcag tgagtggaag 294661 tttgcggcgg tcggtgaagg cacaaacgat acgagattag aagatattat cagtcgatac 294721 gtataaaaga aaaggagtgg atgaaacatg acaatttcat tggcaaaagg acaaaaagta 294781 gatttaacaa aaacaaatcc gggtctttca aaggttgttg tcggtttagg ctgggatacg 294841 aacaagtatg acggcgggca cgactttgat cttgactcaa gtgtgtttct gttagacgcc 294901 gcgggcaaat gcgcgtcacc aaacgacttt attttctaca accagcttga aggcggcaac 294961 ggttcagtcg ttcattcagg cgacaacctg actggtgctg gcgaaggcga cgatgagaat 295021 gtaaaagtaa atctcagcgc tgtaccggca aacattgata aaatctcatt tgttattacc 295081 attcacgatg cagaagcgcg cagccaaaac tttggacaag tatcaaacgc gtttgtccgc 295141 atcgtaaatg aagaaacaaa tgaagagctc atccgttacg atcttgcaga agatttctct 295201 attgaaacgg caatcattgc aggggagctt tacagacata acggcgagtg gaaattctca 295261 gcaatcggct caggctacca aggcggcctt gcccgcattg caacagacta cggtttgcaa 295321 gtcggttaag acaaatacga agagcagaaa ggagagaggc agtatggcca ttcaattatc 295381 aaaaggacag cgcattgatt taacaaaaac aaatccggga ctgactaaag cggtgatcgg 295441 cttaggctgg gatacaaaca agtactccgg cggacacgat tttgacctgg atgcttcggc 295501 ctttttagtt gatgcgcatg ataactgcgt aaatgatctc gatttcgtct tctataataa 295561 ccttgaacat ccgagcggcg gtgtcatcca tacgggtgac aaccgcacgg gtgagggcga 295621 cggagatgat gagcagatta tcgttgattt ctcaaaaatc cctgctcaca ttgagaaaat 295681 cggcatcaca gtgaccattc acgacgctga agcacgcagc caaaactttg gacaagtttc 295741 caatgcattt gtccgcgttg tggatgaaga aacgcagaat gagcttcttc gcttcgattt 295801 gggagaagac ttctccattg aaacagctgt tgtcgtttgt gagctttaca gacacggcgg 295861 cgagtggaaa ttcaatgcaa tcggcagcgg attttccggc gggctggctg cattgtgccg 295921 gaattacggt ttgcaagtgt aagcgagtga caaatagaga agtcaccgtt tcaaattata 295981 ggaggaaaaa acttggactt tttacatcat attttgtcta cgtatgcttc atttttcgat 296041 tggaaaatgt ggggggaagt tctgactgat cctgtttcct ggggtttgat cggttccctt 296101 gttgttctgg aaggcctttt atcggccgat aacgcgcttg ttcttgcggt catggttaaa 296161 cacctgccgg aaaaacagcg gaaaaaagcg ttaacgtatg gtttgtttgg agcttatatt 296221 ttcaggttta ttttcatcgg gctcggtatg cttctcatta aattctggtg gatcaaggtg 296281 cttggcgcgc tttacctggc ttggctcgtc attaagcact tctggatagg cgaaaaagaa 296341 gaggaagcgg acggcatgaa gaaaaactct tggatggtcc gcacgttcgg gatcttctgg 296401 gcgactgtca tttcagtaga attaatggat cttgccttct ctgtggacag catcctggcc 296461 gcgtttgcag tatctgaaaa agtatgggtg cttctgattg gcggtatgct tggtatttta 296521 atgatgcgta cagtggcaaa agtgttcctt gtgctgattg ataaaattcc tgagctggaa 296581 aacacagcat tcgtcttaat cggcattatc gcgctgaaaa tggcggggag cgctttccat 296641 tacgaaatgc cgcactctgt attcttcatt atcattatcg ctgcatttgc ggtaacattg 296701 atcattcact acatcaataa acaaaagcag gtgcgcgaac aaacagccgc ttcaaaagaa 296761 gaataaaaca aaacaaggag ggaggttcaa tgtccttcct tttttgttac cgaaatatcg 296821 tttcaatgac aaaccggaaa ggaggatatg atgagacaag aagaactaac cattcataaa 296881 gcacttccgg ctgatggcga ttggaaaagc ctgctgtttc agccattgcc ggagcgggat 296941 cactatgaaa ctgcacaagg cctttctttt tctcgtcttg ccggtcagat attgggcacg 297001 cctattgatg agacggacta ctataacgag ctgtatgagc tgtctgtaaa cgaccgcata 297061 acgattttga gtgaaacgct tgataaaaca atcgaaccgg aaacatttca aaagcttcag 297121 catattcatt ccatcaatca gaaagaaaaa gggctgtcag tcagccgctt tgttgccttt 297181 ctggacgggg aaaagctgat tgcgaagcac tcaaatccct tgatgcaccg ccatttaaga 297241 aaagcgttga tgacgctttt acataccttt gcggacagtc atgaaaaggg gctgaatcat 297301 cctgattttc gcagagtgct gcttgatgtc tcgaagtttt ccttaaacca tctgaaccct 297361 tggctggaaa aaaccgatat agagcgggag atgccgaagg ttgtttggta tggagatgcg 297421 acgaaaagcc agctctattt cttatattat ctgatgctgg tcggctgtga tgtactgctg 297481 ttccatccgg cgggaacgga tcagctggcg cttgtcgacc cgaagcagga gctcggtttt 297541 acggaaaagc tcccggatgt ttcggagctt cagccgtttc cgaaagaaaa accagaccgg 297601 aaatcaacag tggcttaccg ctcaacaaag gaaattgaac atgtgctgaa tcacgaggaa 297661 tccatgctat ataagccgtg gcagttcaga gatcacacac cggtgtccgt tacgctgaaa 297721 acgacctatg atgaattgtt tttaatcacg aaagaacgcg cctttattcg gccgaatttc 297781 aaagctgata aacattccat tgagattccg aatgtattcg ccaaaattat gggcgtgtcg 297841 aaagacaata aggaatattg gaacaggctt catactctag cggattatca ggaaacagaa 297901 atggtcagaa gctttccatt tacagaagaa ataaagtcga actatcaatt tcactacagc 297961 cacgcacttg atcaagaagg gaacattgat ccggacaagc tgatggcaag caatgtgtgg 298021 cagtacaaac agctgccggc gggcgttcag actgccattg ccaaaacgat ttcgagaatg 298081 tgcaggtacc cgcggcttaa agccttgcat caggaacaag tcaaggatgt tcaaatctat 298141 ttgtttaaac aaacaacaaa cctgcctgct aatctgctga aattgattca aatgttcgac 298201 tatgcgcaaa ccgttccgaa actcgtttta tatcatacgg aaatgagcgg cggactcacg 298261 cgttcggatg ctgccgccct gctgttcctg aatgaaatcg gaatcgatat catcatttat 298321 aatccgcccg gacaccaaga tattgagcag tttattgaag aggatcagta tgatatccac 298381 tggctggatg acatggtgtt tcagcaggac tacaaagagc cttcgcttgt gaaaaggctc 298441 ttcagaacca ttacccaaaa ataaggagag aagaaaagca tgacaacaga aaatcaaaat 298501 ccgcttgttc tcgataaaaa tgaagagatt tcccagcaaa aagctgacga tatccgtctt 298561 cagctccgtc aggaaccaga agtgaagcgg cttgctcaac aaattgacgt caaaaaccaa 298621 atggagctgc ttgagtacgg caaggagccg gccgttgaaa tatccaagtt ctctgaccgc 298681 atcttgggga tgatgaaaac aacaagcgtg acagactccg gcacaatgct gactcagctt 298741 gggaaaatca tggaccgctt cgacaaaaat gattttgatg agccaaaggg attaatggcg 298801 aaaattttca aacgcggcgg cagcatgatt gaaaaaatct ttaaaaagta tcagacgctt 298861 ggcggagaga ttgaaaaaat ccacgttgag atttcaaaat acaaagatga gatgacgaag 298921 acgaactaca cgctcgatga aatgtatgaa aacaatatca aatactatat ggagcttgaa 298981 aaatacgtcg ttgccgggca gatgaaactg gaagagatgc agtcgatcct tccttcatat 299041 gaggaaaaag cggcaagcgg gaaccagctg gcgcaaatgc agctcgatac gttgcgcaac 299101 ggcattcagg cgcttgagga acgggtgtat gatcttgaca tggcacggat ggtggcgctt 299161 caaaccgcac ctcaaatccg tctcctgcag cgaggaaatg caaagctgat cgggaaaatc 299221 aactccgcgt ttatcattac cattccgatt ttcaaaaacg gcattattca ggctgttacg 299281 gtaaagcggc aaaagcttgt ggctgattcc atgagcgagc ttgaccgccg gacaaacgag 299341 atgctgaaac gaaatgctga aaacatctcg agccaaagtg ttgaaattgc gagaatggcc 299401 ggcagaccga gcatagatat tgaaacgatt gaatcgtctt ggaacacgat tgtcagcggc 299461 atgcaggaaa caaaacaaat cgaagaagaa aacaagcgcc tccgcgaaga cggcgcgaga 299521 cgaattgccc agcttcagga taatattaaa aaagcagcat tgcagcaata ataaaaaccc 299581 cgcttgtgga acataagcgg ggtatttcaa ttacatcatt tagttaatga caatgtgtaa 299641 agacaggtgt aaacttaaac ggtaatcatt ttgcatatca gaggtgttgg caatgggaaa 299701 acaacagcct atatcccagc gtaaactgct gggcgtcgcc ggtttggggt ggctgtttga 299761 tgcaatggat gtcggaatat tatcgtttat tatcgccgcg ctccatgtag agtggaatct 299821 gtcgcccgaa gaaatgaaat ggatcggaag cgtcaattcc atcggcatgg ctgcgggtgc 299881 gtttttgttt ggtttgcttg ctgatcgaat cggccgcaaa aaagtgttca tcatcaccct 299941 tttatgcttt tccatcggaa gcggcatttc cgcttttgtg acgagcttat cggcatttct 300001 aatccttcgt ttcgtgattg gtatgggact tggcggcgag cttccagtcg cttcaacact 300061 cgtttcggaa gcggttgtgc ctgaaaagcg gggcagagtg attgtgcttt tggaaagctt 300121 ttgggccgtg ggctggctcg cagcggcctt gatttcttac tttgtgatac caagcttcgg 300181 ctggcaggct gcccttctgt taactgcgct gactgctttt tatgcgctgt acctgcggac 300241 gagtctacct gattcgccga aatatgaatc gctttctgcc aaaaagaggt cgatgtggga 300301 gaatgtaaaa agcgtctggg caagacagta tatacggccg acggtgatgc tgtcgatcgt 300361 ttggttctgt gtggtgtttt cttattacgg catgttccta tggctcccga gtgtcatgct 300421 gctgaaaggc ttcagcatga ttcaaagctt tgaatatgtc ctgctgatga cgcttgctca 300481 gctacctggc tatttctctg ccgcatggct gattgaaaaa gcgggccgga agtggatact 300541 cgtcgtttac ttgattggca cagcaggaag cgcctatttc ttcggaacgg cggattcctt 300601 aagtcttctg cttacggctg gagtgctgtt atcgtttttc aatctcggtg cgtggggcgt 300661 gctgtatgct tataccccgg agcaataccc gactgcgatt cgagcaacag gttcaggaac 300721 gacagcagcg tttggaagaa tcggcggcat cttcgggcct ttgctcgtcg gaaccctggc 300781 agcccgtcat atttcgtttt cggtcatctt ttcaatcttt tgcattgcaa tcttacttgc 300841 ggttgcttgt attttgatta tggggaaaga aacgaaacaa actgagctag aataggaaaa 300901 gcacctctta aaagaggtgc tttcagcgtg tcgacaaacc ctcgcattcg ttgtcaggac 300961 tgcgcttcgg tgctcaatgc gaagtggatc aacggctaaa ttctcaggcg tcctgcctaa 301021 acgccgtcgt catcacatcc tgtgaatgtc cgctcctatg ctcgtccttc ctagacttca 301081 agggttttca atcacgctga aaagattttg tcaacaatct gaggcacctc ttgaatgagg 301141 tgctttttta caattgcgcc cgggctgtgg attggcgttt cccggtttta ctgattgtct 301201 ggtagagcgt catagaaagt atgaacagaa tggcagtaaa tcctgtgaca gctccgaaat 301261 gctgtgtgct ttgatataaa aaacctgcaa tacttgtacc gacagtggtt ccggcataca 301321 tagcggcatt ggaaagggaa gcgatggttc ctcgcgcatt tggtgcaatg gattgaaaga 301381 cacccatcat taacggaaag atgatgccag ctgtaaagaa cgtgagaaaa aagccggctt 301441 ctactaaaaa caagtttgga aagaacggaa gagcgaaata gagagcgccc attagcagca 301501 tcccgctgat cagtgtttta aacatgccca gcttttctga aacccggctg ccgataaggc 301561 tcccgagcat atttcccagt ccgagtacaa gcatagctgc gccaatttgt gacacggtta 301621 aatgataatc cgcggaaagc caagtaccca gaaagctgaa cgatgcgaag tttccggttt 301681 gaaacagaaa ataggcaagc agaatgaccg atgttttcgg caatgaaaaa agctcccgat 301741 aggggttgac aattgatggg cgcgccaatg gttcagaagg ccggatgcca ggcatgaccg 301801 ccgccaggat caatagaaga ataagcgagc acgctgacaa aacgaaaaat ggcgtatgcc 301861 atgtaaagga agcgagaaac cctccaatag gaagtccgag catttgtgaa gcggccaaac 301921 ctgctgtcgc aatccccatg ccttttatga tctgagaagg ctggacaatg actgggatgg 301981 acgcccaaat ttgaggcgtc acaaacgcag cgctaacgcc tgcggcaaaa cggaacaggc 302041 acatggcggc aaaagaggga gcgatgccgc ataaaaatgt ggatacgata aagcctgcaa 302101 gtccccacag catgactgtt ttcctgttca gccggtctga gattgggcct gcaatgaaag 302161 cgaagagtgc ataaccgagt gcataagcac tgaccatcca gcctgacaaa tcagtagaga 302221 catgaaactg atcctgtaaa agggggagaa gcggcgaaag caaaaaggta tccgtgccaa 302281 tgacaaacat gacactgaag aaaagccaaa tgcgattcaa attttatcac tcctattgtt 302341 ttataacttt aaaactatga aacagatatg tatagagaaa accctttgtt agagggtttc 302401 caaaaagcca ggcaggtatg tttgaaatgt gtcttcacgc agactgacgt attttgtccg 302461 cgaatctttc cgggttgccg tcaatcccgc ttcacgcagc gttttaaaat gataagatgc 302521 cgtggttttg acaatattgc acttttcacc tacttcaccg cagctgagtt cttttccgct 302581 gacataaagc gtacgaataa tggcaagcct tgattcatca gacagtgctt taaaaatttg 302641 cgctctgatt tgatcatctg attgtttcat agtcatgaaa ctataataca taatgggtgt 302701 tgaaaaagca acttattttt ccagtaaagg agcaggaagt cataagagga aggaggaatt 302761 caattccaat aaaagcgttt tcaactaaag gtaggagaaa aatcacccgt aaaatacaat 302821 catataggag gattacagag catttagaag cataaataag atcatgtggt cacatggatg 302881 tttataaaga aatggtacag aataaaagag aatatgctgt ttgtgtggga agttacataa 302941 atgttacggt aataaagatt gcttaatatg gagggaaaat atgagtgtag atgagaaacc 303001 aattaagata aaagtcgaga aagtctctaa gatttttggg aaacaaacaa agaaggcagt 303061 tcaaatgctt gccaacggaa agacaaaaaa agagatcctg aaagcaaccg gatcaaccgt 303121 tggggttaat caggcagatt ttgaagtata tgatggtgag atatttgtca tcatgggtct 303181 atcagggagc ggtaaatcaa ctttagtacg gatgttaaac cggcttattg aaccgactgc 303241 cggaaatatt tacattgatg gtgacatgat aacaaatatg tcaaaagacc agctccggga 303301 agtccgccgg aaaaaaatca gcatggtctt ccaaaagttc gctctgtttc cgcacagaac 303361 gatacttgaa aacacagaat acggactgga gcttcaaggt gtagacaaac aagagcggca 303421 gcaaaaagcg cttgagtctc ttaagctcgt tggactggaa ggatttgaac accaatatcc 303481 cgaccagctt tccggcggga tgcagcagcg tgtcggcctt gcccgcgcgt tgacgaatga 303541 cccggacatc cttctgatgg acgaagcgtt cagtgcgctc gatccactga ttcgtaaaga 303601 tatgcaggat gagcttcttg atcttcacga taatgtcgga aaaacaatta tctttattac 303661 gcatgacttg gacgaagcgt tgcggatcgg cgacagaatt gtcctaatga aggacggcaa 303721 catcgttcaa atcggcacgc ctgaagaaat cctgatgaat ccatctaacg aatatgttga 303781 gaaattcgtc gaagatgttg atttgtctaa agtcctcaca gcaggccaca ttatgaaacg 303841 cgctgaaaca gtgcggattg ataaagggcc tcgcgtagca ttgacactga tgaaaaacct 303901 tggaatttct tcaatttatg cagtggataa acaaaagaaa ttattaggtg ttatctatgc 303961 gtctgatgcg aaaaaagcgg ctgagtctga tttgtcactt caagacatct tgaatacaga 304021 atttacgact gtaccagaga atacgtatct gactgagatt tttgacgttg tgtccgatgc 304081 gaatattcca attgcggttg tggatgagaa gcaaagaatg aaaggaattg tcgtaagagg 304141 cgcgctgatt ggcgcacttg ccggcaataa cgagtatatc aatgctgaag gcactaacga 304201 acaaacacaa gatccttctg cacaggaggt gaaataagat ggatagactg cctagaatac 304261 ctttagcaga tattattgac cgttttgttg actggattac gatgacgttt ggcggattct 304321 tcgacggaat cgctaacgga ttggccgctt ttgtaaatgg aattgtcacc ggtcttggat 304381 ttattccatc tattttgtta acgattattt tcgccgcact tgcgtggtgg atcagtacaa 304441 ggggaattgc gttatttacg ttgattggat tcctcctgat cgattattta ggatattggg 304501 acccaatgct gcaaacattg gcgcttgttt tgacatctgt gattatttcg attgtggtcg 304561 gggttccgat cggaatttgg gcgtctcaga aagaaacggt tcgccgtatt gtaacgccaa 304621 ttcttgattt aatgcagaca atgcctgctt tcgtatatct attgccggcg attttcttct 304681 ttaacatcgg tgttgtgccg ggtgttgttg catctgttat cttcgcgatg ccgccgacaa 304741 tccgcatgac tgttctcggt attaaacaag tgccggcgga tttgattgaa gcgactgagg 304801 cattcggttc tacaacagct cagcgtttgt ttaaagttca gctcccgctt gcgacaaaaa 304861 cgattttggc cgggatcaac cagagcatca tgcttgcgtt atcaatggtt gttatcgccg 304921 caatggtcgg tgcaccggga cttggttctg aagtatacag tgccgttaca cagctgaaaa 304981 ccggggtcgg agtagaggcc ggtatcgcca tcgttatcgt tgccattacc ctggaccgta 305041 ttactcaaaa tattaaagtg aagaagaaaa gcagggggaa tgcctgatgc ttaaaaaaat 305101 cataggcatc ggcgtttccg ccatgctggc gctctcactt gcggcttgcg gttcagaaaa 305161 cgatgaaaat gcatccgcag cagaacaagt gaataagacc atcatcggga ttgaccccgg 305221 ttcagggatt atgtccctga ctgacaaagc gatgaaggat tatgacctga atgactggac 305281 attgatttca gcgtcaagtg ctgcgatgac cgctacgctt aaaaagtcat acgaccgtaa 305341 gaaaccgatt atcattacag gatggacacc gcactggatg ttctccagat ataagctgaa 305401 atatctcgat gatccgaaac aatcttatgg cagcgcagag gaaatccata cgatcacacg 305461 caaaggcttc agcaaagagc agccgaatgc cgcaaagctt ctgagccagt ttaaatggac 305521 gcaggacgaa atgggcgaaa tcatgatcaa ggtggaagaa ggcgagaaac ctgccaaagt 305581 tgctgctgag tacgtcaata aacacaagga tcagattgcc gaatggacaa aaggcgttca 305641 aaaggtgaag ggagacaaaa tcaaccttgc ctatgtggcg tgggacagtg agattgcaag 305701 tacaaacgtc ataggcaaag tcttagaaga cttgggctat gaggtaacac ttactcaggt 305761 agaggctggg ccgatgtgga ctgcaattgc gacgggaagt gcggatgcat ccctttccgc 305821 atggctgccg aatacccata aagcatacgc cgctaaatat aaaggcaaat atgatgatat 305881 tggcaccagt atgactggtg tgaagatggg gcttgttgtt cctcaatata tgaaaaatgt 305941 caactcaatt gaagatttga agaagtaatc aaaaaagcag cctgtgtcag gctgcttttt 306001 ttgcgttaag aagcgttagc ggcagcaagt gattccgcct tctgaaatgt tttgagcacg 306061 gcgttcgcca aaatatgaat gccggtaaac atcgcatttc tgtcaaaggt catgtgcgga 306121 tgatggagcc ccggctggag cccgcagcct agtccgagca tcgttgtttt cagattcggc 306181 accttcacgg cgtaaaaatg gaaatcctcg ccgccggtgg tgacaagcgg gtcatcaagc 306241 cgctcagccc cgatgatttc cgtaatggct tctgccatga tcgcttcagc ttctttattt 306301 tgtgttgccg caggaaggct gtgttctttg tgcagctcga tctttgcgcc aaatgcagcg 306361 gcggccgctt cacaggctct ttctgtttcg gcgattaatg cctccatggc ttcattggtc 306421 tgtgcgcgca aatcaaggct gaacgatgct tttcctggaa tgatgttaga gctttcaccg 306481 ccggcttgca gttttgtcat tttgacggta tgcgggattt gcgggtcaat atgaatgagt 306541 ccgagcttgt gtacaagaaa tgccgcaatt tcaatgctgt ttttcccgag gtgcggacgg 306601 gcgccatgag cctcttcccc gatgatcgtt ccctcaatgt gctggcttga tccgtgcaga 306661 atagaaggag cgcagcggcc gttctgtgtt tcctggatcg gacggacgtg aacgccatac 306721 aaatagtcga tatcatcaag cacgccttct tctatcattt tcaaggcgcc gccgcctttt 306781 tcttctgccg gctgaaagat aaaacggatt gtgcccttcg gaagctcagg ttgttttttt 306841 agcagcatta acgtgcccaa tgccattgtc atatgtgaat cgtgtccgca ggaatggttg 306901 gcgcgaaatg tgccgttaac ctcctgccac agcgcgtcaa tatcagcgcg taccgctaca 306961 acaggtgagc ctgagccgat ttcgccgaca accccggtgc agtctgaaaa cgtgcgcgtc 307021 cggcacccta aatcctcaag cttttgtttc aaaaatgaag ttgtctcata ttccttccag 307081 ctgacttcag ggttcgcgtg cagatgctcg aagatgtcca taatggtttg tttcatttct 307141 tctgaaagct tttgcatggt aagaaatacc tccttctatc agaatgaatt tttaccttct 307201 ttactttatt tatattgaaa caggaagata ggctgtatat aatatagcac atattgctac 307261 tattcagaat aattaatatt ttcaaacaga ggggatggat cgaaatatga gtatgccagc 307321 agccgaaaca cagcctaaga aaaaacgtat gacatttaaa atgcctgacg cctatgtcct 307381 cttatttatg attgctttca tttgcgcaat cgcttcatat attgtgccgg caggtgaatt 307441 tgaccgcgtg acaaaggggg atgtcacgac cgctgttccg ggaagctatc attcaattga 307501 acagtctccg gtcagattga tcagcttttt tacttctcta caggatggaa tggttggatc 307561 agcacccatc atctttctga ttttattcac aggcggcacc attgctattc tagaaaaaac 307621 gggtgccatc aatggcctga tttacaatgt catcagcaaa ttccgcacaa agcaattatt 307681 atttatttgt attgtcggcg cattgttctc cattctcgga acaaccggga ttgtcgtgaa 307741 ttcagttatc ggttttatcc ccatcggcct cattgtggca cgatccttaa aatgggacgc 307801 agtcgcggga gccgctgtta tatacatcgg ctgctacgct ggatttaact ccaccatatt 307861 atcaccgtca ccgctcggtt tatcacaatc aatcgcggag ctccctcttt tctcaggaat 307921 cggcctgcga gttgtgatat acatatgctt tttgctgtct tctattattt atatctattt 307981 gtatacgaga aaattaaaaa aatcaaaaga tgccagtgtg ttaggaacag attggttccc 308041 tgcggcagga atgggcgaag ccggtaaaga agaagatcag tcagtgccgt ttaccgttcg 308101 ccataagctg attttggctg tggcgggact ctcacttgtc ggatttttat acggcgcttt 308161 gaagcttggc tggtcagatt cccaaatggc tgcgacattt atttttattt ctgtccttgc 308221 cggtttaata ggcgggcttg cggcgaacga tattgccaaa accttcatta cgggctgcca 308281 aagtcttgta tacggggcgc tgattgtcgg gatggcacga agcatttccg ttatccttga 308341 aaatggaaag cttctcgata ctgtcgtcaa tgctttggct tcacttttgg atggattcag 308401 cccgattgct ggggcaatcg gcatgtatat cgccagtgcg ctgcttcatt ttctcatctc 308461 ttcaggttct ggcgaagccg ttgtatttat tccaatcctg gcgccgctcg ctgatttgat 308521 gggaatcacg agacaggttg cggttgaagc ggttatgctt ggagaagggg tcgtcaactg 308581 tgtgaacccg acatccggcg ttctcatggc ggtgcttgcc gccagcggta ttccgtatgt 308641 caagtggctg cggtttatgg tgccgcttgc tctgatttgg ttcttgatcg ggcttgtctt 308701 tatcgtgatc ggagtcatga tcaattgggg gccgttttaa cgattgctgc ccgccggctt 308761 gtacggcggg cttttgagtt attcattgca gaagcgcagg ctgttattgt aacatgtaag 308821 ccataagcca ttcgtaaaag tgcgggagga aggtcatgaa taatctgcgt aatagacttt 308881 caggcgtgaa tgggaaaaat aagagagtaa aagaaaaaga acaaaaaatc tggtcggaga 308941 ttgggatgat agcgggagca tttgcgctgc ttgatgtgat catccgcggc attatgtttg 309001 aatttccgtt taaagaatgg gctgcaagcc ttgtgttttt gttcatcatt atcttatatt 309061 actgcatcag ggctgcggca tccggaatgc tcatgccgag aatagacacc aaagaagaac 309121 tgcaaaaacg ggtgaagcag cagcgaatag aatcaattgc ggtcgccttt gcggtagtgg 309181 tgcttacgat gtacgacagg gggattcccc atacattctt cgcttggctg aaaatgattc 309241 ttctttttat cgtctgcggc ggcgttctgt ttctgcttcg gtatgtgatt gtgaagctgg 309301 cttacagaag agcggtaaaa gaagaaataa aaaagaaatc atcttttttg tttggaaagc 309361 gagggaagcg ttcacagttt cgggcagctt tttttatagg aacattgatt tgtattcact 309421 ctgccaagtt gttttgatag agtgattgtg ataattttaa atgtaagcgt taacaaaatt 309481 ctccagtctt cacatcggtt tgaaaggagg aagcggaaga atgaagtaag agggattttt 309541 gactccgaag taagtcttca aaaaatcaaa taaggagtgt caagaatgtt tgcaaaacga 309601 ttcaaaacct ctttactgcc gttattcgct ggatttttat tgctgtttca tttggttctg 309661 gcaggaccgg cggctgcgag tgctgaaacg gcgaacaaat cgaatgagct tacagcaccg 309721 tcgatcaaaa gcggaaccat tcttcatgca tggaattggt cgttcaatac gttaaaacac 309781 aatatgaagg atattcatga tgcaggatat acagccattc agacatctcc gattaaccaa 309841 gtaaaggaag ggaatcaagg agataaaagc atgtcgaact ggtactggct gtatcagccg 309901 acatcgtatc aaattggcaa ccgttactta ggtactgaac aagaatttaa agaaatgtgt 309961 gcagccgctg aagaatatgg cataaaggtc attgttgacg cggtcatcaa tcataccacc 310021 agtgattatg ccgcgatttc caatgaggtt aagagtattc caaactggac acatggaaac 310081 acacaaatta aaaactggtc tgatcgatgg gatgtcacgc agaattcatt gctcgggctg 310141 tatgactgga atacacaaaa tacacaagta cagtcctatc tgaaacggtt cttagacagg 310201 gcattgaatg acggggcaga cggttttcga tttgatgccg ccaaacatat agagcttcca 310261 gatgatggca gttacggcag tcaattttgg ccgaatatca caaatacatc tgcagagttc 310321 caatacggag aaatcctgca ggatagtgcc tccagagatg ctgcatatgc gaattatatg 310381 gatgtgacag cgtctaacta tgggcattcc ataaggtccg ctttaaagaa tcgtaatctg 310441 ggcgtgtcga atatctccca ctatgcatct gatgtgtctg cggacaagct agtgacatgg 310501 gtagagtcgc atgatacgta tgccaatgat gatgaagagt cgacatggat gagcgatgat 310561 gatatccgtt taggctgggc ggtgatagct tctcgttcag gcagtacgcc tcttttcttt 310621 tccagacctg agggaggcgg aaatggtgtg aggttcccgg ggaaaagcca aataggcgat 310681 cgcgggagtg ctttatttga agatcaggct atcactgcgg tcaatagatt tcacaatgtg 310741 atggctggac agcctgagga actctcgaac ccgaatggaa acaaccagat atttatgaat 310801 cagcgcggct cacatggcgt tgtgctggca aatgcaggtt catcctctgt ctctatcaat 310861 acggcaacaa aattgcctga tggcaggtat gacaataaag ctggagcggg ttcatttcaa 310921 gtgaacgatg gtaaactgac aggcacgatc aatgccaggt ctgtagctgt gctttatcct 310981 gatgatattg caaaagcgcc tcatgttttc cttgagaatt acaaaacagg tgtaacacat 311041 tctttcaatg atcaactgac gattaccttg cgtgcagatg cgaatacaac aaaagccgtt 311101 tatcaaatca ataatggacc agagacggcg tttaaggatg gagatcaatt cacaatcgga 311161 aaaggagatc catttggcaa aacatacacc atcatgttaa aaggaacgaa cagtgatggt 311221 gtaacgagga ccgagaaata cagttttgtt aaaagagatc cagcgtcggc caaaaccatc 311281 ggctatcaaa atccgaatca ttggagccag gtaaatgctt atatctataa acatgatggg 311341 agccgagtaa ttgaattgac cggatcttgg cctggaaaac caatgactaa aaatgcagac 311401 ggaatttaca cgctgacgct gcctgcggac acggatacaa ccaacgcaaa agtgattttt 311461 aataatggca gcgcccaagt gcccggtcag aatcagcctg gctttgatta cgtgctaaat 311521 ggtttatata atgactcggg cttaagcggt tctcttcccc attgagggca aggctagacg 311581 ggacttaccg aaagaaacca tcaatgatgg tttctttttt gttcataaat cagacaaaac 311641 ttttctcttg caaaagtttg tgaagtgttg cacaatataa atgtgaaata cttcacaaac 311701 aaaaagacat caaagagaaa cataccctgg aaggatgatt aatgatgaac aaacatgtaa 311761 ataaagtagc tttaatcgga gcgggttttg ttggaagcag ttatgcattt gcgttaatta 311821 accaaggaat cacagatgag cttgtggtca ttgatgtaaa taaagaaaaa gcaatgggcg 311881 atgtgatgga tttaaaccac ggaaaggcgt ttgcgccaca accggtcaaa acatcttacg 311941 gaacatatga agactgcaag gatgctgata ttgtctgcat ttgcgccgga gcaaaccaaa 312001 aacctggtga gacacgcctt gaattagtag aaaagaactt gaagattttc aaaggcatcg 312061 ttagtgaagt catggcgagc ggatttgacg gcattttctt agtcgcgaca aatccggttg 312121 atatcctgac ttacgcaaca tggaaattca gcggcctgcc aaaagagcgg gtgattggaa 312181 gcggcacaac acttgattct gcgagattcc gtttcatgct gagcgaatac tttggcgcag 312241 cgcctcaaaa cgtacacgcg catattatcg gagagcacgg cgacacagag cttcctgttt 312301 ggagccacgc gaatgtcggc ggtgtgccgg tcagtgaact cgttgagaaa aacgatgcgt 312361 acaaacaaga ggagctggac caaattgtag atgatgtgaa aaacgcagct taccatatca 312421 ttgagaaaaa aggcgcgact tattatgggg ttgcgatgag tcttgctcgc attacaaaag 312481 ccattcttca taatgaaaac agcatattaa ctgtcagcac atatttggac gggcaatacg 312541 gtgcagatga cgtgtacatc ggtgtgccgg ctgtcgtgaa tcgcggaggg atcgcaggta 312601 tcactgagct gaacttaaat gagaaagaaa aagaacagtt ccttcacagc gccggcgtcc 312661 ttaaaaacat tttaaaacct cattttgcag aacaaaaagt caactaaccg caactttaga 312721 gtaaagggct gattgtcaat gtgggagcag ttgtatgatc cgtttggaaa cgagtatgtg 312781 agcgcacttg tggcgctcac tccgattctc ttttttcttt tggctttaac tgttttgaaa 312841 atgaaaggca ttcttgcggc atttcttacc ctagccgtca gtttcttcgt ctccgtttgg 312901 gcatttcata tgccggttga aaaagcgatt tcttctgttt tgttaggaat cgggagcggg 312961 ctgtggccca ttggctacat cgtcctgatg gcggtgtggc tgtataaaat cgccgtgaaa 313021 accgggaaat ttaccattat tcggtccagc attgccggca tttcgcctga ccaacgatta 313081 cagctattat taattggttt ttgttttaac gcgtttttag aaggcgcggc cggttttggt 313141 gttccgattg cgattagtgc ggcgctgctc gtcgaacttg gttttaaacc gttaaaagcg 313201 gcggcgctct gcttgattgc aaacgctgcc tccggagcct ttggggcgat tgggattcct 313261 gtcatcacag gggcgcagat tggtgatttg tctgctcttg agctgtctcg gacattaatg 313321 tggacactgc cgatgatctc atttttaata ccattcctgc ttgtattctt attagaccga 313381 atgaaaggaa tcaaacagac atggcccgct cttctggttg tgagcggtgg gtatacagcg 313441 gttcagacac tgacaatggc ggtgctcggg ccggaattag caaacatttt ggcggcctta 313501 ttcagcatgg gcgggcttgc cctcttcctc cgcaaatggc agccgaaaga gatttaccgc 313561 gaggaagggg ccggcgatgc tggtgagaaa aaggcatacc gtgccgctga cattgcgaaa 313621 gcgtggtctc ctttctacat tttaactgcg gcgatcacca tctggagcct tcctgccttc 313681 aaagcgcttt tccaagaagg cgggctgtta tatcaatcaa cgctcctgtt caaaatgcct 313741 tttctgcatc agcaaattat gaaaatgccg ccgattgcgc catctgccat gccgttagat 313801 gcagtcttta aagttgatct gctgtcagcg actggtacag cgattttagc ggcggtcatc 313861 gtgacagggc tgttcagcaa aaagttctcc tctcgggatg cctttgcttc cttgaaggag 313921 acgggaaaag agctgtgggt gccgattatg acgatctgct tcgtgatggg gtttgccaat 313981 ctggccaact tcgcagggct cagctcttca attgggttag cattggcgaa aacaggagac 314041 ctgttcccgt ttgtcagtcc tgttctcggc tggattggcg tgttcatcac cggttctgtt 314101 gtcagcaata atgctttgtt cggccatttg caggttgtca cgggagcgca gatcggtgcg 314161 ggttcagatt tgctgttagc cgcaaatacg gcgggcggtg tcatggcgaa acttgtttct 314221 cctcaatcta tcgccatcgc tgccgcagcg gtcggccaaa caggcaagga atctaaactg 314281 tttaaaagga cagtggcgta cagcctgatt ctgttattga tcatttgtat atggacgttt 314341 attcttgcaa gattaggagt gtaatagaaa aaagcagtac atgcccagca tgtactgctt 314401 tttttatgtt aatttgcttt ctttgtcatt tcggctgttg ttttcactct ggcttttccc 314461 ataaataaaa tggtaaccgc cgcgaggaca attggaatca aagcgagcaa aaagacatac 314521 gtgatacttg atgacatcgc gtcaataatg cgattcagga tcgcatcagg aatctgggaa 314581 cgtgttcccg cttggaatat ctcctgcggg tcgccaatat tttgcgcagc gcctgatccc 314641 gctgagcctt tcataccgct gaaggcgtca ttcagcttgt ttgtgaatac gtttgtttgc 314701 accgttccga aaatggtgac acctaaggtc atgccaaatg atcgcaaaaa tgaatttgta 314761 gagtttgccg ttccccgaaa gcgaggttca agatcattca tcgatgccgc cggcagcagg 314821 gagaagttaa agcctacacc aaagcctgaa atcatcataa agactgtcag ccatacccgt 314881 gctgtgtcag gcgtcatatt ggaaagaagc agcatgccga taaagaaagc tataacagat 314941 atcagcatca aattgcggaa gcttgccttc gtttggaaga tcccgccgat catgcttccg 315001 atgactgatc caatcatcat cggcgtcaga atgaagcccg cgcttgtcgc cgagctgccg 315061 tagaccgcct gaacgaaaat cggaataaat accgctaaaa taataaatgt tccgccatac 315121 aggaaagcga gaatctgtgc tgtggcaaac aagcggttct taaacatcca gaaagaaata 315181 atcggctctt ctgcttttct ctccacaata aaaaaggcaa tgaagaaaac ggcgaataca 315241 ataaacagcc cgatgatctg aatggagttc caatcgtatg ttttgccgcc aagctcaagg 315301 gcgaacatca ggcatacaat ggatacgact aaggtaatcg cgccgcccca gtctattttc 315361 tgctttctgt gctccagaga ttctttgtag tagcgaataa tgaaaaacaa tgacaatgcg 315421 ccgatcggca cattgatgta aaacacccag tgccagctga tcgaatctgt aatgatcgcg 315481 cctaagagcg gaccaagaac actggataat ccaaatacag caccgaacat gccggacatt 315541 tttccgcgtt tttccggcgg aaacaaatca aagataatgg taaaggcaat cggcaggagc 315601 gcgccgcctc cgatcccttg aatggcccgg aagatgatca gctgattcat cgtctgggca 315661 atcccgcata aagcagaacc gattaagaaa aaaataagtc caaacaggaa aaaacgtttt 315721 cggccgtaca tatcggaaag cttgccgtaa atcggcatgc cagccataac cgccaccata 315781 taggatgccg tcacccaggc aaatttatcg aagcttccaa gatcggctac gatattgccc 315841 atcgcggtgg caacaatcgt attgtccatt gcagacatca agatgcccag caggagaccg 315901 aggaccacaa atttggtgga agcctgtttt gctgttgttg tgtccatttg ttctacctcc 315961 tcttactttt ctatgtaagt tctgatatca tgataatagt ttgattgttg aatatctcga 316021 ttatcaagat aaactcgatt ttatagggag gactgtcagt tgtcaacaag aaattccaga 316081 agtgagttgg aaaagactgc tgttcagctt tttcgaaaac tgggcacaag aacggttctg 316141 tttcatcagg cagccgctca agctctcggt ctgtttccca ccgatttgaa atcagctgac 316201 attttaaatg aagcagggcc gatgacggcc ggagagctgg ggaaaaaaac cggcctcagc 316261 acgggttccg tcacggcgct tgttgaccgg ctggaaaaag cggggtatgt ggctcgtgaa 316321 aaggacccga acgatcgcag gagagtcgta atcgtccctt tgactgcttc gaaaaaacat 316381 ataaaggatt tgttccgtcc tctgtctgag tcaacgatgg atttgtgccg cgaatatacg 316441 gaagaggagc tggaactcat tttcagtttt gtaggcaaag ctgccgatat tatggaggaa 316501 gagcttgaac gtctgaaaca gtaagtgaat ttgtgcatag cttggcccgt tcccgaataa 316561 attgtacaag ttacataaga gaagggagta cgggccggtg aacatttttt tgagctatat 316621 tgtgctggga ctgtccttgt ctgcgcctgt ggggccagtg aatgcggcgc aaatagacaa 316681 aggaattaaa aacggttttt ggcatgcatg gattttcggt ttaggcgcca tgacagcgga 316741 tgggctgtac atgcttttta tctatttcgg gctgtcgcag ttcttgaccg ctccatttgt 316801 gaaaacgttt ttgtggctgt tcggcttttt tgtcctgacc tataccggaa ttgaaacgct 316861 gaaaaacgtc agagaaccga tggatgtgcg aagctcgcgg gggaaaccgt catacaggaa 316921 aacattcgca tcgggttttc tcatttcatt gtcaaaccca ttgagcatcc ttttttggct 316981 tggaatttac ggaagcattc ttgcgaaaac agcagaggcc tacaatatga atcagcttct 317041 aatctatagc tccggcatca tgatcggcat tttaatctgg gatttctgca tggctatcac 317101 agccagtacg ttcagaaacc tgcttcatga aaagctattg agaggattga ccggaatcgc 317161 cggtgtatcc ctccttgtgt ttggctttta ctttggttat cagggcatca aacagttatt 317221 gggctgattc atgaaggaca gtcacctgcc gcttccagtt ttaatatagt atccagatga 317281 tactggaggt ggatcaatgg tgaatgggat ttacaccaaa agttttctgg aacgtattca 317341 ggaagagctt cctgaatggc aaagaatcgc ttttgagctg ctggcagaaa ctctggggga 317401 cgacgcggat acatttccgt gcattcccgg acgccaggcg tttctgactg atcagcttcg 317461 gattgctttt gccggagatc cgcgggaaaa ccgcacagcg gaggaactgg ctccgttgct 317521 tgcggagtac ggcaagatat cgcgggacac gggaaaatac gcatccctcg ttgtgttgtt 317581 tgatacaccg gaagatttgg cggagcatta ttcgattgaa gcgtatgaag agctgttttg 317641 gcgcttttta aatagactga gtcatcaaga cgaaaaagaa tggccggaag acattccggc 317701 cgatcctgag cattataaat gggagttttg ttttgacggc gagccgtatt tcattctgtg 317761 cgctacaccg gggcacgagg caagaagaag ccggagcttt ccttttttta tggtcacgtt 317821 tcagccaagg tgggtgtttg atgacctaaa tggatcaact gcatttggcc gtaacatgag 317881 caggctgatc cgatctcgtt tagaggccta tgatcaggct ccgattcacc cgcaattagg 317941 ctggtacgga ggaaaagata atcgtgaatg gaagcagtat ttcctccgtg atgacgaaaa 318001 acaggtatcg aagtgcccgt tttcttattt aaagaacatg ttcaacaaaa tgaaataaat 318061 caaggactgg cagggcgatc tttatgaccc tgcttttttt gatagatcat ggtaacgatg 318121 gcgataatca cgagaaaacc tatgctgacg aaaaaaccgg gccggcttga tttttcaaac 318181 aatgtaccgg acacagctgc agcaatcaga accatcgcta aataaatttg cgtttttccc 318241 atgccctcgg gatcagtcag ctttttgctg gagaacagga taaacagcca agtgtataaa 318301 agcataagcc ccgcagctgt tgtcatatgc tcataaatgt ttttaggcag cactaacgac 318361 aaaataatgg agaggacaag ccccgcaaac gtcagcccaa gtgccggcca gcatattttt 318421 ttgccttcct ttagagtaaa gcatttcggc gcgtcgccgt catcagccat tgtacaaagc 318481 aatgtcgtaa ccgcaaatag cgaagcgaca agggtcgaga accctgcgat gatgaaaatc 318541 ccgttaaata tatcaaggat gatctcaagg ttatatcctt ttaatgacgt aatgaacgga 318601 ctgtcctgtt cagtaaacgt gtgtaacgga accaaaagca gagcaagccc gattgaaatg 318661 atataaataa tcgccagcgt cgccagcatc agtttccctg atttagacgc ttcctcaggt 318721 ttttttaagt gaaccgccat cagccccatg acctcaattc cgccaaaagc gtaaaacgcg 318781 tagattaaac ctgtccacag ccccatggcg ccgtatggga aaaactcact cgtcttattt 318841 ggaacatgta tgccatgatt tccgccggac aggataccgc ataaagccag gatggcaatg 318901 acaataaaca taaaaatagc agctgtttta atgactgcca gcacgttttc tgttttttca 318961 aagacggaca ggccggtgaa aataataagg agcccaagta ctgcgtagat tgaggcaaac 319021 acccatagcg gcacttgagg aaaccaatgc ttcgtaaaga gcgaaatggc tgtcagctgg 319081 cttccggtaa tcagcatttc tgatgtccag tacacccagc cgttgctgaa gcctgcccat 319141 ttgccgaatg cttttcgggc atacgcacaa aacgagccct tttccggctg cttcgccgat 319201 agcttggcga gctgttcaaa gacaaaatac gtaccgatcc ctgcgatcag aaatgaaagg 319261 agaacggaaa aaccgctttt tacaattgcg atgctggaac cgagaaagaa gcctgttcca 319321 atcgtgcagc cgactccgat cagtgacagc tgccaccaag ccagattccc ttttggctgg 319381 tctttttttg tttggctcat tatttattca acccctttta tctaaggtta gattgtgatc 319441 tgtccaaagc ttatatacat cggatttttg cctcttttta catggagaag gaagcagacg 319501 ctcatactaa tgaaaaaagg agcaaaccaa tgacacagca atatattgtg gagccgaaaa 319561 aagggcttgg gctgaagctg aaaaaggggc agattttaaa ggtggttgat gtagaagggc 319621 agcaggtggc tgattttgtc gcataccatg ccaaggattt ttatgaacac cttgatcagg 319681 gagcgacgat agacgccaat cactccattc atgtgaaggt caacgaccat ctctactcca 319741 acctgtataa gccgatgtta accctgattg aagatacggt cggcaagcat gatctgctgt 319801 tgcccgcctg ccgtcctgat atgaacaggc tcttatatgg gaagcaaaag gatgagtttc 319861 aggatacgtg ctatgacaat atgaaccgtg cgcttgagca gtttggcgta ccgaagcccc 319921 acatgcatta cccatttgcg atttttatga atactgtcct tgatgagaaa gggaatctgt 319981 ctgtggaaac gccgctttcg aatgccggag attatgtaag gctcagggcg gagatggatt 320041 taattgtcgc gttttcttcc tgcccgattg aaaaagggaa atgcaatggc gacagtgtga 320101 catccatacg ggttgaagtc agctgatctc tcttgttcac agtgaatgaa gacctgtgct 320161 atatttaata gggatacata acagtcatga ttcattttca ttgatttagg gaaatgatca 320221 gtaataaggg aaaatgtaca ggaggaatga ttgggatgag catgcaggaa aagattatgc 320281 gtgagttaca tgtgaagccc tcaattgatc caaagcaaga aattgaggac cgagtcaatt 320341 ttttaaaaca atatgtaaag aaaaccggtg ctaaaggctt tgtattggga atcagcgggg 320401 gccaggattc aacacttgcg ggaagactcg ctcagcttgc ggtggagagc attcgcgagg 320461 agggcggaga cgctcaattt atcgcggtcc gtcttccgca tggcacacag caggatgaag 320521 acgatgccca gcttgctttg aagtttatta agccggataa atcatggaag tttgatatta 320581 aatcgacagt cagcgctttt tctgatcagt atcagcagga aacaggcgat cagctgacgg 320641 actttaataa aggaaacgta aaagcaagaa caagaatgat cgcgcaatac gcgatcggcg 320701 gccaggaagg tcttcttgtg ttaggaacag accatgctgc tgaagcagtg actggtttct 320761 ttacgaagta cggtgacggc ggagcagacc tcctgccgct gacaggcttg acgaagcgcc 320821 agggaagaac cttgctgaaa gagctgggtg caccggaacg cttatactta aaagaaccga 320881 ctgccgatct gctcgacgaa aaaccgcagc agtcggatga aacagagctt ggcatttcct 320941 acgacgagat tgacgattat ctcgaaggaa aagaagtatc agcgaaagta tcagaagcgc 321001 tggaaaaacg ctacagcatg actgaacata aacgccaggt tccggcgtct atgtttgatg 321061 actggtggaa ataagttgaa gaaagcccgc tctcggagcg ggcttttgtc gtgtacagaa 321121 gctttatttg atgcggatat gattcagctt taccattaat ctgtcggcga accttcggag 321181 gctgcctctt gtatcaggat ctaatgggag ttcggctctc gcggcaatgt tctctgccac 321241 atcctgaatc gacaggttgt ctgtttgaat gtggtcctca aaaatgggtg atgataatcc 321301 ttcaacacag cggtcaattt gtttggcggc ccatgagttt tttccttctg ctctggtgcg 321361 cagccttttt aacaaggttt cctttgaagc cattagtgta aagtggtgaa cgatcctgcc 321421 ttcctgtctg agcctgccga tgatctcatt gaagtattca gggtgtacaa tcgtcatagg 321481 cacaataagg atgccgcggt atgtatctgt cagagaagct agcaaactgt aattgaacgc 321541 ccgccataaa ggatagcttt gaaaatcgtc ctttgcgatc tcctgcggca ccatggagcg 321601 cagcgcaaaa cccattttct cgggatcata cacgtaagat gggttcagcc ttctgtgcag 321661 ttcgaaggct gtttgtgttt ttcccgaacc gaatgccccg tttatccaaa tgatcatcgc 321721 catttctccc ttcctattta tcatacagaa aaagaccctt ccatcgaaga gtcagctgga 321781 aaaacaataa aggcggaagg ttttaacgct tttttgcgtc gaagtattaa aatacctgca 321841 gaaatgttgt acaatgaatg tcattcaggc aaaaatggct acaacaaagc gcactataag 321901 cttgaccggt aaagccggta tctatataaa tattcgctaa ataagcatat aatgaatata 321961 taatttcatt ccttaggagg atttcgccga agatgaacgc taaacgagcc atcccagtaa 322021 gagaaagaaa tatcgtcctg atcggattca tgggtgtagg aaaaacaaca atcggccaat 322081 tggtcgctaa aaaattatat agagatttta ttgatattga ccagcagatc gaaaaggatt 322141 tcaatatgtc aattcctgag atatttgaga aaaagggaga agactttttc cggaaaacgg 322201 agaaggaata tattttagac atctgccatc ataaacgatt caaaatcgta tctctgggcg 322261 ggggatcttt taaacaagaa gaaatcagaa attgctgtct ggaaaactgt ctcgtgcttc 322321 atctggacct gtcatgggag aactggaagc agcgcgcgga tttattgatc gaaagccgcc 322381 ctgtactgca taaccgttca atggatgaaa tggaacagct gtttaacgaa agaaaagtca 322441 tttatgacaa gcacaattca aaagtggcaa cagacaacct ttccccggaa gaggttgccg 322501 attacattgt tgagacatta aaaattggct gggatcttta tcagccgatg taaaaagccg 322561 tgcgcagcgc acggcttttt ttatcgtttt atcccttgta tcaaaatcgc ttttaaacaa 322621 aaggagatgg gctgtccgtt ttggttcaat gtaatacaga acgtgtcgcg tgcttcgtct 322681 gatgcgtgat tcaagtgggt aatgatttgt ttttctcggt cagcgggggt tccgcctcgt 322741 ttgatccagc tatcgtattg aatcggcaag ttccactttt ggatgtcttg ataggccagt 322801 tgattggcgc tgaacatcgc ctgccattct gataatgagc tttcacgaac atgggaaggg 322861 tctcgaagcc ggttcaaatg attgacaaac tcatcaagaa cgggatcttc aggcgcgtaa 322921 tgatcaacta agagaaaacg tccgtcctgt tttagtacgc gtgcaacctc tctgacagct 322981 ttgcggacat ctgaaaaatg gtgggctgcg tatcggcagg tgatgatgtc aaatgaatcg 323041 tcggggaagg ggagtgactc tgccgttcct tgctgaaagc gtacgttttc aactcctttt 323101 tcttgcgcga aggaggacgc aacctcaacc atctctttcg ttgcatcaac accgatgcac 323161 tcctgtacat aaggagaaaa tgccagcgcc gtatggccgg cgcccgctcc tatatccagc 323221 actcgatgct ctgcccggca ttccgctgtt ttgatcatca accccaaatc ttccccctcg 323281 gcaaatacct tttcatcccg atacatctcg gcgtttttag aaaacggtgt ttcatttgtc 323341 atttgaacca gctccttctt ttcgtaaatg atgatatgga ttatgttagc aatttctgtt 323401 atgattcgtc caagatataa aaatgatgaa aatgataggt tcaacctatg gaggctgaaa 323461 tggatattaa agtgatggaa tatgcagcgg aaattgcccg gcgccaaagc tttacaaagg 323521 cggcggaaca tcttcatatc gcacagccgt ctctcagcca gcaaatcaaa aagcttgagg 323581 ctgagctggg gcttaccctt tttcacagat cccatggctc tgttacactg acacctcacg 323641 gcaggcgttt cattgaaaaa gccgaggaca tcattcgttc cagagatgat ttgcttcggg 323701 aaatgcagga gcgatcacag ggaatcggtc ataaattatc catcgggatt cctgctgtaa 323761 cagggagata tctctttcct ccgctgctga agcagttttt ggcgcgctat cctcatgtgg 323821 aggttcagct tgttgaaaaa gatccggttt cattagagaa gatgacggca aagggagaag 323881 ttgacctttc tgttttatcc ttgcccatcg aggatgaacg gctctccatt acacccttgc 323941 tcacggaacc ggttgttctc gcggtgccga aggaaaaaca aaggtggatg ccgccggaat 324001 tggtcgcgct gattgagaaa gcgctggaag aagatgaggg acgccagccg tgtgtgccga 324061 ttgacatggt aaggaacgtg ccctttattc tgttaaaaga aggcttcggc tttcgcagga 324121 cagttctcga tctctgtgcg gaaagcggct ttaagccgaa tgctgccttt aagacgagcc 324181 atattgaaac cgcccaatct cttgtggcta acggattagg tgtgacaatg gcaccgaata 324241 tggtcagaag ggataaagat ccgggtgtga tctatttatc gattcaatcc gcgccatcac 324301 gaaccctcgt ctttgtcttt ttaaagaacc gctatgtcag tctgacggcc caggccttta 324361 tggaactaag ccgggaaagt cttaaacaaa cgtttgatga aggctgtctg ggaaacaaag 324421 atgaaaatat ttagaaaaca aagacgaaac gtggtagtat aggaatacaa actaaatctt 324481 ataaaacaaa ggggaataat cggaaatgca actattcgat ctgccgctcg accaattgca 324541 aacatataag cctgaaaaaa cagcaccgaa agatttttct gagttttgga aattgtcttt 324601 ggaggaactt gcaaaagtcc aagcagaacc tgatttacag ccggttgact atcctgctga 324661 cggagtaaaa gtgtaccgtc tcacatataa aagcttcgga aacgcccgca ttaccggatg 324721 gtacgcggtg cctgacaagg aaggcccgca tccggcgatc gtgaaatatc atggctacaa 324781 tgcaagctat gatggtgaga ttcatgaaat ggtaaactgg gcactccatg gctacgccac 324841 attcggcatg cttgtccgcg gccagcagag cagcgaggat acgagtattt caccgcacgg 324901 tcacgctttg ggctggatga cgaaaggaat tcttgataaa gatacatact attaccgcgg 324961 tgtttatttg gacgccgtcc gcgcgcttga ggtcatcagc agcttcgacg aggttgacga 325021 aacaaggatc ggtgtgacag gaggaagcca aggcggaggt ttaaccattg ccgcagcagc 325081 gctgtcagac attccaaaag ccgcggttgc cgattatcct tatttaagca acttcgaacg 325141 ggccattgat gtggcgcttg aacagccgta ccttgaaatc aattccttct tcagaagaaa 325201 tggcagcccg gaaacagaag tgcaggcgat gaagacactt tcatatttcg atattatgaa 325261 tctcgctgac cgagtgaagg tgcctgtcct gatgtcaatc ggcctgattg acaaggtcac 325321 gccgccgtcc accgtgtttg ccgcctacaa tcatttggaa acaaagaaag agctgaaggt 325381 gtaccgctac ttcggacatg agtatatccc tgcttttcaa actgaaaaac ttgctttctt 325441 taagcagcat cttaaaggct gataaatgtg aaaagccgcc gcatatcatc aggcggtttt 325501 tttctgcaaa ctgccggaat gagaacagac tggagacgaa tagatatgaa acaaagaatc 325561 attgatgaat taaaacggat cgagcagtca tacggagtca aaatcgtgta tgccgtcgag 325621 tcaggaagcc gcgcatgggg atttccctcg caggatagtg attacgacgt ccgctttatt 325681 tatgttccga aaaaggagtg gtacttttca attgagcagg agcgtgatgt cattgaggaa 325741 ccgattcacg atttgctgga tatcagcggc tgggagctga gaaaaacgct tcggcttttc 325801 aaaaagtcaa accctccgct actcgaatgg ctgtcctcag acattgtgta ttatgaagca 325861 tttacgaccg cagagcagtt aagaaaactc cgcacggagg catttaagcc tgaagcaagc 325921 gtgtatcact atatcaatat ggcgagaagg aacgtcaagg attatctaca aggacaagag 325981 gtcaaaatta aaaagtactt ctacgttctt cggcctattt tggcctgcca atggattgaa 326041 aagcacggaa ccataccgcc aatggacttt actgttttga tgaatgaact tgttgctgaa 326101 cccgagctga aggctgaaat ggaaaccttg cttgaacgga aaagaagagg ggaagagctt 326161 gacctcgaag caagaatcga tgttattcac caattcattg aaacggaaat cgaaagaatc 326221 atggaagcgg caaaagaact gaaggcagag aaaaaagata tgacatctga attgaaccgt 326281 ttgcttttga atacggttga agaagtgtgg aaggatggag gaagctgatg ttttttgtcg 326341 cttccttttc tcctttattc gacagaatcc ccccccgact ttctaactat ctgattgtgg 326401 caaacccaca aaaataatca gaatctttgt attttgagaa tattgtgaac gctggttttg 326461 tccatttaca ataaactcat acaaatactt cttagattgc ggggtgttga ggttggaagt 326521 gatcacaaga gattttttct tatttttatc caaaagcggc tttctcaata aaatggcgag 326581 gaactgggga agtcgggtag cagcgggtaa aattatcggc gggaatgact ttaacagttc 326641 aatcccgacc attcgacagc ttaacagcca aggcttgtca gttactgtcg atcatttagg 326701 cgagtttgtg aacagcgccg aggtcgcacg ggagcgtacg gaagagtgca ttcaaaccat 326761 tgcgaccatc gcggatcagg agctgaactc acacgtttct ttaaaaatga cgtctttagg 326821 tttggatata gatatggatt tggtgtatga aaatatgaca aaaatccttc agacggccga 326881 gaaacataaa atcatggtca ccattgacat ggaggacgaa gtcagatgcc agaaaacgct 326941 tgatattttc aaagatttca gaaagaaata cgagcatgtg agcacagtgc tgcaagccta 327001 tctgtaccgg acggaaaaag acattgacga tttggattct ttaaacccgt tccttcgcct 327061 tgtaaaagga gcttataaag aatcagaaaa agtagctttc ccggagaaaa gcgatgtcga 327121 tgaaaattac aaaaaaatca tccgaaagca gctcttaaac ggtcactata cagcgattgc 327181 cacacatgac gacaaaatga tcgactttac aaagcagctt gccaaggaac atggcattgc 327241 caatgacaag tttgaatttc agatgctgta cggcatgcgg tcgcaaaccc agctcagcct 327301 cgtaaaagaa ggttataaca tgagagtcta cctgccatac ggcgaggatt ggtacggcta 327361 ctttatgaga cgccttgcag aacgtccgtc aaacattgca tttgctttca aaggaatgac 327421 aaagaagtaa aaaaggagag attatcatga caacacctta caaacacgag ccattcacaa 327481 atttccaaga tcaaaacaac gtggaagcgt ttaaaaaagc gcttgcgaca gtaagcgaat 327541 atttaggaaa agactatccg cttgtcatta acggcgagag agtggaaacg gaagcgaaaa 327601 tcgtttcaat caacccagct gataaagaag aagtcgtcgg ccgagtgtca aaagcgtctc 327661 aagagcacgc tgagcaagcg attcaagcgg ctgcaaaagc atttgaagag tggagataca 327721 cgtctcctga agagagagcg gctgtcctgt tccgcgctgc tgccaaagtc cgcagaagaa 327781 aacatgaatt ctcagctttg cttgtgaaag aagcaggaaa gccttggaac gaggcggatg 327841 ccgatacggc tgaagcgatt gacttcatgg agtattatgc acgccaaatg atcgaactgg 327901 caaaaggcaa accggtcaac agccgtgaag gcgagaaaaa ccaatatgta tacacgccga 327961 ctggagtgac agtcgttatc ccgccttgga acttcttgtt tgcgatcatg gcaggcacaa 328021 cagtggcgcc gatcgttact ggaaacacag tggttctgaa acctgcgagt gctacacctg 328081 ttattgcagc aaaatttgtt gaggtgcttg aagagtccgg attgccaaaa ggcgtagtca 328141 actttgttcc gggaagcgga gcggaagtag gcgactatct tgttgaccat ccgaaaacaa 328201 gccttatcac atttacggga tcaagagaag ttggtacgag aattttcgaa cgcgcggcga 328261 aggttcagcc gggccagcag catttaaagc gtgtcatcgc tgaaatgggc ggtaaagata 328321 cggttgttgt tgatgaggat gcggacattg aattagcggc tcaatcgatc tttacttcag 328381 cattcggctt tgcgggacaa aaatgctctg caggttcacg tgcagtagtt catgaaaaag 328441 tgtatgatca agtattagag cgtgtcattg aaattacgga atcaaaagta acagctaaac 328501 ctgacagtgc agatgtttat atgggacctg tcattgacca aggttcttat gataaaatta 328561 tgagctatat tgagatcgga aaacaggaag ggcgtttagt aagcggcggt actggtgatg 328621 attcgaaagg atacttcatc aaaccgacga tcttcgctga ccttgatccg aaagcaagac 328681 tcatgcagga agaaattttc ggacctgtcg ttgcattttg taaagtgtca gactttgatg 328741 aagctttaga agtggcaaac aatactgaat atggtttgac aggcgcggtt atcacaaaca 328801 accgcaagca catcgagcgt gcgaaacagg aattccatgt cggaaaccta tacttcaacc 328861 gcaactgtac aggtgctatc gtcggctacc atccgtttgg cggcttcaaa atgtcgggaa 328921 cggattcaaa agcaggcggg ccggattact tggctctgca tatgcaagca aaaacaatca 328981 gtgaaatgtt ctaagcggga ctaaatgggc atcctccctg cgggggtgtc catttcatcc 329041 atatactata aaaaagagga ggaagtgcca tagaaaacac acagctgatt atttcgattt 329101 gtatttatat ggcgggaatg ctgctaatcg gctactttgc ttacaagcgt acgtcgaatc 329161 tgacggatta tatgctggga ggacgctctt tgggtccggc agtaaccgct ctcagtgccg 329221 gcgctgccga tatgagcggc tggctgctaa tggggcttcc gggcgccatg ttttctactg 329281 gtctgagcgg cgcttggatc gtcatcggac tttgccttgg agcgtgggcg aactggcttt 329341 acgtcgcacc acggctgaga acctatactg aaaaagcggg gaattctatt acaattcccg 329401 gattcctgga aaatcgcttc ggagatcaaa caaagcttct cagactgttt tcgggaattg 329461 tcattttagt ctttttcacg ttttatgtat cgtccggaat ggtgtccggc ggcgtcttat 329521 tcaacagcat cttggggatg gattatcaca ccggcctgtg gattgtgacg ggtgttgttg 329581 tggcatatac cctgtttggc ggctttttgg cagtcagctg gacagatttt gttcagggga 329641 ttattatgtt tgccgcactc attcttgtgc cgatcgttac gtttttccac acgggaggag 329701 caggtgatac agttgctgaa atccgctctg tagatcctga tatgtttaat attttcaaag 329761 gaacgagcgt ccttggcatt atttctttgt ttgcctgggg gctgggatac tttggccagc 329821 cgcatattat tgtgcgtttt atggcgataa cgtctgtcaa agagatcaaa agagcgcgca 329881 gaattgggat gggctggatg attttgtctg cagtaggcgc agtgctgacc ggtttgggcg 329941 gaatcgctta ttaccatcag cgcggcatga cactgaagga cccagagacg atttttattc 330001 aattagggaa tatcttgttc catccgatta tcacgggttt tctgatttca gcgattttgg 330061 ccgcgattat gagtacaatt tcttcccagc tgcttgtgac atcaagctct ctggtagaag 330121 atttgtataa gtcgatgttc agacgctcag cttcagataa agaactggtg tttttaggcc 330181 gactggctgt tctggctgtt tcaattgtcg cgttggttct ggcttgggag aaaaataaca 330241 ccatccttgg attggtcagc tacgcgtggg cgggcttcgg tgcatcattc gggccagttg 330301 tactgctcag tctgttttgg aaacgaatga ccaaatgggg ggcactcgcc ggcatgattg 330361 tgggagcagc gactgtaatc atttgggcga atgccggtct ttcggacttt ctgtatgaaa 330421 tgatacctgg ttttgctgcg agtctattat ctgtcttttt tgtcagcata ttgacgcagg 330481 ctccgtcaca agctgtcaca gaccagttca acgactacca agatacaatg tcgcaataaa 330541 gatcgaaagg aggaggaagg ggctgtccct ttttcctctt ttctcctttt aagcggccat 330601 ttttttcttt tggaaacaaa cgtatttttt tctatacaaa aagaccccgt atggatatga 330661 ttaaagtaaa aaaagtatag gagaaaaagg tatggaagag cttttagaga gagttttttc 330721 attttcagat gttgataagc taattgattt tattagctat gaactgcaaa agccagtgat 330781 actggaaagc gcggatttct ttttgttagc ctataattct tactatatta accattttga 330841 ttctgccaac cagcagacta ttttttcgaa aaagtgtccg gtccagattt ttgagaggtt 330901 tctgaaggac ggaattattg aaaaattgaa aacagagcct gagccttttc gcgtcaataa 330961 aattgaaagc attgggttaa accagagggt ggtcgtgagt gcaaagcaca aaggggaagt 331021 catgggctac atctggattc aggagctgga ccaaaatctg acggatgaag agctcgactt 331081 tttgtacgag acctccttcc atgtcgggaa aatcatttat aaaacgaata aattgaaaca 331141 ggaaaaggaa gaaaaagcag aggatctcat caaacgggcg atctatcagc aatttacctc 331201 tgagaaggaa ctcagacggg aagctgaaag gatcaacacc gtgctgcctt ccatgttttc 331261 agttgttatc ctgcacgccg caaatgggga tggggaagcg gttgaggatt taaaggaaaa 331321 tatcaggtcg tacctgaatt tacgggataa ggtcagtcat gtcttaacga tcgaatcaaa 331381 cattgtcatc gtcgtagcga gtttttccca aaaaagctcc gtctcctcag cagcttctga 331441 gtttattaac aagctgttaa cacattttca ctttcaaaaa atacctaccc ctatttatat 331501 cggtatcgga aacgaatata atcacctatt aaaacttggc aagagctaca cagaagcact 331561 tgaagtcatc aaagccgcag aaatcaccgg caatcaggaa aacattccat atgaatatgc 331621 caaactcggc atttaccgct atttagaaag catcgaacag aaaaatgaat ttttagaata 331681 cgagaataaa gatttagctt tattaaaagc aaaagacgaa gaaagcagca ctgagctgct 331741 caaaaccttg gaaatctatc tcctcaacaa ctgcaaaaca aaaccagcgg cagaacagct 331801 gtttattcac caaaatacat tgaattaccg catcaaacag attactgaga tgacgtcgat 331861 cgatttaagc gatttcagaa cgcggtgcca gctctatctc gatttgatgc tgatgaaaaa 331921 gaaataaaaa agaaaccagt acttgtactg gtttcgtctt cacttaaaat cctctgtaaa 331981 catacggatc atcaggtttt ttaatggtat tccagtcagt tactttgacg acagggagag 332041 ttgacttgaa tggctggtaa tattctgagg ccagagtgcc cttaatgtga atccattcat 332101 catccttgat gtccatgtcc ttcggaaatt ccacaagcat cccgtacacg ccggaatcag 332161 cgatacagtg aatgatgcca aaccttaata cgaacagctg atttttgtta attgcgtttc 332221 ctttgtaagc aaatccatga aattctatcg tccgtccgag aaattcaccc ggatagttat 332281 agatggtttc cattcctttt aggaaatcgt catcggtcag agaaatctct tttttgctgg 332341 aatacttatt aaacagctgt ttcatttgtt tgtcatagct gtcttgcgcg taataaaggc 332401 tggcatcagg ccgcaaatac tgtgtttggg agtagtgatc tccgctctcc atcgccttaa 332461 acgagaaccc ttttgttttg actatggatg agtcaagcgt tgcaatcggg aagaagatgc 332521 ctgacaccaa aggaaaaaga aaaacaacat aaatcaaata acgctgataa aatggcttgt 332581 tttgttcatg gtcatgctcg tgatcatggc cgcacccgca atcatggtca tggtgatgtc 332641 cgcttttttc aggcgacttg ataaatagat atgcttggac ggcggtcaga atggccagca 332701 ggaagatcgc aataaaggaa agataggcat atttcatatt gatatatttt gttagatttc 332761 ctgaggcatg cagatgataa aagaaaaacg taaatcccat cagcaccaat aaacgaaaca 332821 tccaatcacc cctttaccag tagtgatccc gctaaaacaa tcacgacaat gtatgtaatc 332881 agcaggaaaa caaatcgttt tttgaaggcc gcaagcatca tcaatagatt cttaatatcc 332941 accattgcac caaagacgag aaaggcgatt aacgatccta atgaaaacgt gctgctgaag 333001 gaagacgcga tgaacgcatc aacttctgaa caaagcgaca ggacaaacgc cagacccatc 333061 atcacgaggg aagaggatac atcattctgc ccgatcgcaa gcagagtgga tgttttgaca 333121 tacgtctgca tagcggctgc gataaaggcg ccgatgatta aatatttccc cacggagaaa 333181 aattcatcaa tggcatgccg caaggtcccg cccagttttt ggagcaaggt gccgtgatga 333241 tgatggtggt gcccgggttc atcaggcttt aaaagctggt tatccttaaa ttgataggat 333301 aagatgaccc cgatgatcag cgaaacggcg agagccagtc cgcctctgta aaagaccacg 333361 ctccatctat tcccgaacgc aatataagta gaaaataaaa cgataggatt aatgataggc 333421 gcggtcagca tgaaagcaac gcccgcatgc agaggaactc cctttaacag aagccgcctc 333481 gtaatcggga tgatgccgca ttcgcaggcg ggaaataaaa cgccggccag cgcaccgaat 333541 aaaacggcga gaaaacggtt tttcggcatg attcttgcaa tcatttcttc agaaacaaac 333601 atttgaatga ttccggaaag tatgacgcca atcagaataa acggaatggc ttctattaaa 333661 atgctgataa aaatagaatt cagctgaaga aaagatgatt gtgctgtcac aataaaacct 333721 ccgctcatgt taagctgcct ttcttatgat accagaaaaa aaggcactgc ttgtttgacg 333781 gaggagggga aaggatcgtt tcactttggt taggattcca aaaagccgag taggatactg 333841 cctgtttctg cagcttcttt tccgagccaa atcaggtgtc cccatgagtg aagcaaacag 333901 agaacagcgc cacgaatgtg ctcttttgca tgatgtgcat gtgacaagtc aaccaatccg 333961 tcataaacac tttgcataat cagcacggga catatgatgg cttgcaggtc ttttaaagag 334021 acagcggcgg tttgtgacaa gtcaatcaga aatccttcac ccgagcgctg ccggctgttc 334081 attttccgaa atgcttctat gtctttttca ttcatcaagg acttgattcg ctgaaacgga 334141 agcgtgctga attgggggct catagctcga aacatcaaac gcgggaaagc gttattcaag 334201 gaagaaatca gcttccatat ccacttttcc accggcgggc ggaagagaat ttcccccaat 334261 ttatattcag tgtcttttgg ggtgagccac tctttggtga ctgcggattg cagggtcaat 334321 gtatttactc tttccggata atgtgaggca aagcatatgc cgctcggccc tcctgctgag 334381 atggcgatca catggacact ctcgatttgt agatgatcta ataatttcac atagaaacgg 334441 caggcattgg caagactttt tccaatttct tttgacgtcc gtccatagcc aggccttgaa 334501 ggcgtaatga tggaataccc ttgttcaatc aacgctgtgt atccgaattc ctcgtaacaa 334561 tttgaatgcc cgccatgcat gacaaggatc ggagttccct tgcctgtcac agaatattct 334621 agtgtaccgc catcgaaggt gatcgtttca actcgtcttt tcatctgttt cacccaattg 334681 gtttttgcct attatagagt tttcagcaat tgaccacaag gtagaagaaa tgaataaaca 334741 aaggcccttg aaatatgata tactttgtat tgatattcat tctcaattaa aactttgata 334801 tagatgtgaa cgggaggcag gacggatggc tgagaatcaa gaggtatatg acgttacgat 334861 tataggcggg gggccgatcg ggctgtttac tgctttttac tgcgggatgc gggagctgaa 334921 aacaaaggta atcgaatttt tgccgaagct cggagggaag gtgtctttat tctttcctga 334981 gaaaatcatt cgcgatatcg gcggcatacc ggggattgcg ggaaagcagc tgatcgagca 335041 gctgaaggag caggcggcaa cgtttgatcc tgatatcgta ttgaatcagc gtgtgaccgg 335101 gtttgaacgc ctagatgacg gcaccattgt tctgacgggt tctgaaggga aaaagcacta 335161 tacaagaact gtgattttgg cttgcggcat gggtacactt gaggtcaatg agtttgacag 335221 cgaggatgcg gcccgatatg cgggcaaaaa tcttcattat ggagtggaga agctcgatgc 335281 gtttaaaggg aaacgcgtgg tgatatcagg cggcggagat actgcggtcg attgggctaa 335341 tgagcttgaa ccgattgcgg cgtctgtgac tgtcgttcat cggcgtgagg aattcggcgg 335401 aatggaaagc agcgtgacga aaatgaagca atcatcggtg cgggtgctta cgccttatcg 335461 gctggagcag ttgaacggag atgaagaggg catcaaaagc gtgaccgttt gtcatactga 335521 gtctggccag aggaaagaca tagaaattga tgagctgatc attaatcatg ggttcaaaat 335581 tgatctcggg ccgatgatgg agtgggggct ggagattgaa gaaggaaggg tgaaagctga 335641 cagacatatg cgaacgaatc ttccgggcgt gtttgtggcg ggcgacgcgg ctttttatga 335701 aagcaagctg agattgattg ccggcggatt tacggaaggc ccgacagcgg tcaacagtgc 335761 caaggcttat ctggacccta aggccgagaa tatggcgatg tattccaccc atcataaaaa 335821 attggtgcat aaataaaaca gcccttgagg aaaagggctg cttgccatca ggtgtgaagg 335881 agttttttct ctgcatgttg attgtggatg aaagctagca attcatcctg ttcttgtacg 335941 gctgtgaatc cataaatgcc ggcagctgag tcatcgccta tgcagacgat aggagggcgg 336001 cttgctgacg gttccggcaa aatgccaatt tgttcgccac cattgatcaa ttgctgaacg 336061 gacagcttgt ttgggcaaat gaccatgtgc agcggggatt cactgatggt acgctgaatc 336121 atgtgggtga accggtcatc tatgacgttt tcatgagtga tataaaacga acaggattca 336181 tgcttttgca tgttttccac tgcatggcgg ctcccgacaa caagacgttt ctctgaatca 336241 ggctgaatgg cggtgacaag aaagccccgt ttctcaagct ctgtctttgc ttgctcagat 336301 gctgcactca gtttggctgt cagctggcgg atgtcgattt tctgagaagc cagtgctctg 336361 aaaaattcac aaaccgcccg gcgcgatgtg aaaaaaacgt cttcaaaggt gccaatcttt 336421 cgaagaattt cttcattgac aggcatgttt tcggtccgcc atttcggcca ctcgatgaga 336481 tcggcgccgg aatcgcgcag cttgtctgca agcgggtctt catcttcgcc atgagtcaca 336541 accatcaaat gccgtccgat gagcggtttg ctttcaaacc agctgtgtgt ttgaaagttg 336601 acgatgtctc cgatgacgat aatcgcaggg tttgtaatct ggtgttcctg cactttttgc 336661 tgaatgttct caagtgttcc tttcacactc cgctggcggc cccacgttcc ccattggatg 336721 acaatgacag ggacagaagg cgatttcccg tatgaaataa gctgctggca aatataagac 336781 aagttcttga cacccatgta aaaaacaagg gtttgaacgc ttcgggccag cccttcccag 336841 tcaaggttcg gcgtgccttt taatgattta tcatgcgctg taatcatggc aaaagacgat 336901 gcaaaatccc gatgcgtgac ggggatgccc gcatatagcg gcgctgcaat tccagaggtg 336961 attcccggca ccatttcata gcgaatgccg tgctcatgaa gagcatctgc ttcctcgccg 337021 actctgccga atacgctcgg atctccgccc ttcaagcgaa cgacggttaa cccatttaat 337081 gctttttcaa ccagcagggc gttaatttct ttttgtttca taaaatggcg gtttggcagt 337141 tttccgcaat aaataaactg gcagtccggt gatgcaaatt cgagcagctt cgggttggcg 337201 agccggtcat ataaaatcac atctgcttcc ttgagcgcct gttttccttt gatggtgagc 337261 aggcctgggt cgccgggtcc ggctcccacg aaatatacga ttccgttctt catgatcatg 337321 tcatccttcc gtcactgtaa aaaatgaagg accactagaa aagtgatccg gtcttttgat 337381 caatatacga gataaacatg ttctccttcg atcagcgttt catatgtttt gacgcatccg 337441 tggtcaggtt cttggacgat tccgtcttct aaggaaattt tccagtcgtg catcgggcag 337501 aaaacatatt gaccgctgac gatgccttct gccaggacgc cgcccttatg cggacagcgg 337561 ttttcaatgg cgcggatgct tccgtctgaa agcttgaaaa ccgcgagctc cttatcttca 337621 atatacactg ttttgcctaa ttgttcaggc aattcttcaa tttttccgat acatactttt 337681 gttacgtctt tgtttaccat gtccattcct cctcaatgat agtttttgtc attatgatgt 337741 ggtcacgaca ttttcaaata attctttaga ggtttgttta tcctctaaaa agtctttcca 337801 cggatccttg tggacagaga gtgtttcatt cattcggccg ttcagctcct gccgcttttc 337861 cggatcgttt aacacggatt ggacatggga taaaccgacg cgctcaagcc atgcggacgt 337921 acgctccaga tagtttgcgg tttccctgta atattgcagg taagcgcccg cgtattctaa 337981 gacttcttca tttgttttca ccttcatcag caaatcgccg gcacgcaaat gggttccgcc 338041 gtttccgccg acataaagct cccagcctcc gtcgatgccg acaacgccaa ggtccttaat 338101 gccggattcc gcacagtttc gcgggcaggc agacacggcc attttgactt tgtgaggcgt 338161 gttcagccct tcgaattttt tctcaagcgc aatgcccagt gccatggagt cttgtgtgcc 338221 gaagcggcag aattgctcgc ctacacatgt tttcactgtg cggagcgttt ttccgtacgc 338281 gtagcccgat ggcatatcaa gatcttccca taccttcgga aggtcttctt ttttcacgcc 338341 gataagatca attcgctggc cgcctgtcat tttcacgagc gggatctcat atttgtcaac 338401 gacatcggcg atcttgcgca aatctgtgga gttggtcacg ccgccgtaca tccgaggaac 338461 gactgagtat gttccgtctt tttgaatatt ggcgtgcatt cgttcattaa caaagcggga 338521 tgtccggtca tcctcgtatt tggttggatt gatcatgcct aagtagtagt tcagagcggg 338581 tcggcattta gaacagcctt ctggcgtttt ccagccgagc acattcatga cttctcttgt 338641 atgtgacagc cctttggctt tgatttcttc tacgacttca tctctcgaca atgtggtgca 338701 gccgcaaatg gcttcttttt gcgctgacgc atcaaagtct gatccgagcg tatgctggag 338761 gatttcttct acgagcggct tacagcctcc gcatgagcgg gatgcgccgg tgcatgcttt 338821 gatttcgtcc gttgacgagc agcccttttc ctgtatggct tgaataatcg caccttttga 338881 cacgccgtta cagccgcaga tgatttcatc gtcgctcatc gctgcggtta tgcttgtgcc 338941 tgcttcctgg ctgaggggct gtaagattga tattttagag gtttcagaga tatcggcttc 339001 tttttgaatc atagaaaaca ggcgattgcc ttcgctgctg tcgccgaata aaacagcacc 339061 gacaatttga ttgcctctca ggacaatttt tttatagatg ccgtcctgct catcgaagac 339121 tttaatcgct tttttctcct ctgattcgtt aaagtcaccg gcagagaaga cctcgacgcc 339181 tgataccttt aactgtgtgg agagaacgga gccctcatac ggttttgttt cgatgccgca 339241 catatgcttt gccagcactt ttgcctgttc atacagcggc gccacaagcc cgtaggcgat 339301 tcctcggtgc tcggcacatt cgccgaccgc gtaaatgtgc gggatttcag tctgcatata 339361 atcgttgacg atgatgccgc ggttaaccgg aatgccgctc tcggccccga gcgttgtatt 339421 tgggcggatg ccgacagcca tgacgactaa atcagcttca atgcttgtgc catccttgaa 339481 tcggaggcct tcgacacggt cgtcaccgac aatttcttct gtttgctttt caagtaaaaa 339541 ggtcatacct tgtttttcta actcgttttg cagcaggcgt cctgccgttg catcaagctg 339601 gcgctccatc aggaatgggg caaggtggat gacggacacg tccatgccga gattcagcag 339661 tccgcgagct gcttccaaac caagtagtcc tccgccgatg acggcagctt ttttatattg 339721 ttttgacgcg gcgagcattg tgtctgtatc ttttatgtcc cggaaagctg tgacgccttt 339781 tttgtctgcg cccggaatcg gaaggataaa agggaccgat cctgtcgcca ggatcaattc 339841 atcgtaaggc tggattctgt ctgcatctgt gatgactgtt ttgttttccg tgtccacttt 339901 gatgactgtt tcatttgtat acaattgaat gttgttttct tcgtaccagt cccaatcgtt 339961 taacgtaata tctttaatat ctgtatcgcc ttgaagcact tttgacaaaa ggattcggtt 340021 gtaattggga tgcggttcgg caccgaaaat tgtgatctga aactcgtctt tagcaacact 340081 cagtatctct tcaatggccc ttaccccggc cattccatta ccaacaagaa ctagctgttt 340141 ttttcccatc agatgatccg ctccttatca aatgtttttt ccagcgtagc acagcaaaaa 340201 ggaatattta agatacatgt tataaaatgt aacaaaatat acgaaaagtt ctaaaaattt 340261 tatgaaaaat ttaaataggt atgattcgga cggcgcatac cttaaaaccg ggcattttac 340321 aggctggatc taaggcttcc ccgattaaat cattcacatt ttgagcgtct gcccaatgga 340381 tgggaacaaa aacggtatct tttctgattt gttctgataa tttgctgcgg acggtgatgc 340441 ttccccgcgg cgattctatt tttaccagta cacggtcctc gatattgtag gtcgctgctg 340501 tttgcggatg gatctccata aacgattcaa aatgtctcgc ggcaagggcg gcgctttttc 340561 ttgtttggac gcctgttaag tagtgagaca tgactctgcc tgtcgttaaa taaagcggat 340621 aatcggctgt cggcttctct tttggaacag gtggttcgtt tggaatcaca cttaatgccg 340681 ctttttgatc cggatgagca aatgattctg taaacaagcg cccagttccg ggatgatcag 340741 attccggaca cggccaatga atgccgcctt cacgtctgag cctgccgtat gagatgcctg 340801 aataatcggc aatcccgcct cggctcgctt ctctcaattc attgaaaata tcctccgctg 340861 acgtataaga aaagtagcgg cccttgccga gagcggatgc gagatcacaa atgatctgcc 340921 aatcatgctt tgcttcgccg gggcatggcc ggcttgcttc tcttaatgtc acgcgtcctt 340981 ctacatttgt catggtgcct tcatcttcta agtaagagga ggcaggtaaa atcacatctg 341041 cgtatttcgc agtctcagaa ataaacaaat cgattgcgac aaagaatgtc agtcttctta 341101 aagccttttt cacgagattt gcatttggac tggaaacagc agggttggag cacatgagga 341161 acagtccttt gatgtcgccg tcattgattt tttccatcat ttcataggct gagacacctt 341221 ttcgcgggag ttcatcctga tggattcccc acactttcgc aatatgcgcc cggtgttctt 341281 cgttttcgat agaacggtag cctggaagct gatcggcttt ttggccatgc tctctggcgc 341341 cttgcccgtt gccttgtccg gtgatcgccc cgtagcccga gtaaggtttg ccgatttttc 341401 ctgtgatcag caccatgttt aagaagcctt tcacagccgc tgttccatcg gtttgctgtt 341461 caatcccgcg ggctgtaaac agcatgccgg acgtttcctt ggcaaacttc acagcagctt 341521 ttcttatatc caccagcgag acactcgtct gttcggcgat gtcattcagg tccaacgagt 341581 cagtatgctg cttcagctct tcgaatccat ttgttcgtga ttgaatgaaa tcctcgttta 341641 taagctgttc gtcaatgatg attttgacga gaccgttggc aagggcggcg tctgtgccgg 341701 gtttgatttt cagatgaaga tcggcgattt tcgttgtcgc tgtttcacga ggatcaatgg 341761 caatgaagta agctccgttt tctttcgctt tttcaaaata cggcataatc gtaggctggc 341821 attccgcaat attggtgccg gccagaatga tcacacgggt gtgggggatg tctgataaag 341881 gattcgttaa gcctctgtcc gcgccgaatg tttggttggc tgcggtggct gctgcggaca 341941 tacaaagtct cccgttgtag tcgatgtatt ttgtctgtaa gcctactcgt gcgaacttcc 342001 ctaacaaata cgcctcttca tttgtaatcg aggcgcttcc gtataccgcc atggcgtcat 342061 gtccgtgttc agtttggatc attgtcactt ggtctttgat atgattcagt gcttcttccc 342121 aggaaacagg cataaactcg ccgtttttct tcagcagcgg ccgggtgatg cgggaggagt 342181 tcaaggcatg ctggtgagca ttcatgccct tgatgcatag ccgaccctgt gtcgtaggat 342241 tatcaatccc gatcgcagtg tactttttgc gcgtgacgat ggtttgttcc acgagctgca 342301 ttttgcactg catgctgcaa aacgggcatt gagtgtcata tgttttttct gattggacgt 342361 cttgctgttt atcacggaaa tatctaagca gtcgttcagt caaaatgcct catcctttct 342421 tatatgcgcc cgtctctaca gtcgggtttt gaatcagtga cagatctgtt tggaggcttt 342481 ccagcagctg tgcccttagg tcttcttcga atagcacttc tctgatatga acgatcccga 342541 gacggtctat ccactgatga acaccttcta agtaatgagc cgtttcccga taatactgga 342601 tcagtccttt gatcatgccg gcagtgctgt cttcgttctc agtcacgcaa aacaaagctc 342661 ctgaacgggc atgagttccc cggacgccgc cgatgtgaat gtcccagcca gcttgtgtcc 342721 gaattgcgcc gacatcttgc agggcggcct cggtgcagtc tgtttcacat gataagctga 342781 tagaaatggg agcgggtaag ggaagcatct caagttgtct ttcgatttgg gctgccagct 342841 gctgaatcga tcgattttgc ccgcatgtac atgctttgat gctttgcagc gcgtgtcggt 342901 gttcattagt gtaaacgggc attttcaggt cttttttcat gttcgggaga tccgcaggct 342961 tgatcccgga aagcttcagc ctttggccgt gagtgatgga tacgtcggga atgctgtatg 343021 cctcaatgat gttggcgatg gttcttagct gctccgcgtt tgtccgcccg ccgtacattt 343081 gcggaatcag gatgcatgtc tcttcagtgg ctggctcagg ctggacaaac ccagggtaca 343141 gcatttccag atagtattga atcgcaggaa cacaagtact gcatccgttt tttgttttcc 343201 agtcaagctg gttcatcact tctgccggat tagtgaatgg cctgcgctga agctcagcga 343261 tgatgtcgtc ttctgtaaaa tcagtacagc tgcaaaacga aggtgtgctg gcgggcttcg 343321 tatattcgct gttggtcatg tatctcaaaa ggtcttcaac gagcggtttg catcctccgc 343381 aggacccagt ggctttggtg cagtgcttga cttcctcaac agttgttaag ctattcgtgt 343441 gcaccgcgtc ttcaatcgcg cctttcgtca ctgtgttgca ttggcaaatc gtttcactgg 343501 aaggcatgga ttcaaataaa gggccgcttg tctccggttc gatgatctgt tttttggcaa 343561 tggagatgtc tcgttgttta agcaggctgt cgagaagccg ctgcttgtca cgggtgtctc 343621 cgaataaaat aacgccggcc agtttgtcat ctacaaaaag cgctttttta taaacgcctg 343681 cttgttcgtc gtagattttg atgctcgtcg tgcgttcatc ctcttggatc tttcctgctg 343741 accacacatc gattccagct atttttaacg ccgcagatgg tgctgagcct tgatattcct 343801 cacatggaac gccgcaaata tgactggcga gcgcttttcc ctgctcataa agcggagcca 343861 ccaatccgta caccgttccg ttatgctcag cgcattcacc aacggcgtag atattcggtt 343921 cgcttgtctg catgaagtca ttcacgatga tcccgcggtt cactttgatt ccagcggata 343981 cagccaattc aatattcggt ttgacgccgg ccgccatcac aatcaagtct gcttttaatg 344041 aagagccatc tttaaaatgg attcggtctg ccttcgtggc gccggaaatg gagacggtgt 344101 ctttctccaa aagaaaggtt aggccttttt gttccagctc tgtttgcagc agccgcgccg 344161 ctgtttgatc gagctgtttt tgcataatgc cggcggagtg gtgaatgacg ctgacatcca 344221 taccgagatg ctgtaaacct actgcagctt ccagtcctaa taagccggct ccgattaccg 344281 cagccttttg aaagtgctgg gccatgttca tcagcgcttg gcagtcttct attgtccgaa 344341 atccatagac accttttttg tctgccccgg ggatagggag aatatgaggg gaggagcctg 344401 ttgccactat taatttgtca tacgacagag tgcgtttccg atctgtgatg acctgctgct 344461 gatctgtatc aatctgaata accgtttcgc ctgtgtaaag cgtgatcccg tgcttgtcgt 344521 accaatcctt gctgttcagt gtaatatcat cgagtgacgc ttcaccctgc aatacagagg 344581 ataagagaat gcgattgtaa ttgggatgcg gctcgcttcc gaaaatgaca atctcaaaca 344641 tgtggcgatt cagctttaat acttcttcaa tacagcggat tccggccatg ccgtttcccg 344701 ctaacactaa tctttgtttc ttcatgtatc agacctcctt tggcgaagct cgtaagtttt 344761 ctcctattaa aaattatgtc acaatgcatt gttaacgcat taaacgtgtc acaaaaactt 344821 acacatgtct tttccagaaa ataatggtcc tatatccttg attcagaaaa tgtaaaataa 344881 tgagggtcta gaaaggggaa tcttatgaag ctgtcggaac tgaaaactag cggtcatcca 344941 ctcactttgc tctgttcctt tttatacttt gatgtcagtt ttatgatatg ggttatgctt 345001 ggggcgctgg gtgtttatat ttctcaggat tttggcctgt ctccttttga gaaagggctt 345061 gtcgtagctg tgccgatttt atctggatct gtgtttcgta tcattcttgg tattttaacg 345121 gacagaatcg gaccgaaaaa aacggcagtg atcgggatgc tggtgacgat gattccgctg 345181 ctttggggga cattcggcgg ccgttccctg actgagctgt atgccatcgg gattctgctt 345241 ggcgtggcgg gagcaagctt tgctgtagcg ctgcctatgg ccagccgctg gtatccgcct 345301 catttgcagg gacttgcgat ggggattgcc ggagcgggga acagcggcac gttgtttgca 345361 accctgtttg gccctcgtct ggcagagcag ttcggctggc acattgtcat gggaattgcg 345421 ctaattccat tattgatcgt ctttattctt tttgtatcca tggcaaagga ttcccctgca 345481 cagccgtctc cccagccgct caaaagctat ctgcatgtgt ttgggcaaaa ggaaacatgg 345541 tttttctgcc tgctgtacag cgtcacattt ggcggatttg tcgggctctc aagcttttta 345601 tctattttct ttgttgatca ataccagctg tcaaaaattc acgcagggga cttcgttaca 345661 ttatgtgtgg cggcggggag ctttttccgg cctgtcgggg gcttgatttc agatcgtgtc 345721 ggcggcacga aagttctttc tgtattgttt gtcatcgtgg cactgtgtat ggccggagtc 345781 agtagcctgc catctctctc aatggttatt gttctattgt ttgtcggaat gatggggctc 345841 ggaatgggaa acggcgcagt attccagctc gtgccgcagc gcttccgcaa agaaatcggc 345901 atggtgacgg gaatcgtcgg tgcggccgga ggaatcggag ggtttttctt gccgaacatc 345961 ttaggatctc tcaaacagat gacaggcaca tatgctatcg gttttatcac gttttcctgt 346021 atcgcgctgc tggcgtttgc acttgtgctt gccgcaggct attactggcg gaaaagctgg 346081 agcgcggaaa gcagcccggc ggatgtttag gattttgacg gacacgcgtt tgtgcgtgtc 346141 ttttttattt tctcttgatt ttcaacagtg aaccgatcaa aataaatagt aattattacg 346201 atttgttagt gagaggagtt ttctgaatga atcaacatac gctgctcccg aaaaaaacgg 346261 agcgtcttca atactttgga tcggtcagtc cgatcaaagg cgagaaacca gtggaaaaag 346321 agaaaatgaa ggacctgcaa aatatcagga aggattattt ttttgacatt cagcatgtag 346381 gtgtagctaa tgtgtcccat ccagtcacaa tcacttctgc catgatgcct gccgagcaaa 346441 caacggctgc gaactttaca atgacttgta atttgccgag aaatcagaag gggattaaca 346501 tgagccggtt aacagagctg ctgcaagtct atcatcaaaa tggctggatt ctctcatttt 346561 cctctcttca gcaatttacg aaagagcttg cagaaaacat ggacacatca tctgccacag 346621 ttgaagtgag gtttccgtgg tttttcgaac ggaaaagccc gaagcttgag aaagcgggtt 346681 tgatgcatgc tgatatattc atgtctgtca cctatcgcaa agatcagccg tttaaacagc 346741 gtgccggcat ctcagcaaaa gtaacgactc tgtgcccttg ctccaaggaa atcagcgaat 346801 acagtgccca taatcagagg ggaacggtca gcatttgggc ggatattcac ccggccgcat 346861 cgctgccaag tgatgttaaa gctgatttgc ttcacgccgc agaatcaaat gcttctgcga 346921 gactgcatcc ggtattgaag cggcctgatg aaaaagccgt gacagaaacg gcctatgaaa 346981 acccgagatt tgttgaggat ctcgcccggc tgattgctgc agatttgttt gagcttgaat 347041 gggtgtcagc ctttgagatt gaatgccgaa atgaagaatc gatccatctt cacgatgcct 347101 atgcgaagct gtgtttttcg aaggaagtgg ataaaatatg aaactctcat tattcattat 347161 tgcagttctt atgccagtca tcctgctgtc agcctgctcc gatcatgcag aagaacacgc 347221 aagtatcaat acaaagaaaa cggtcgaaaa cataacggac gttcgaaaaa cagcaaaaac 347281 aagcattgat tggacaaagc cttcgggcgg agaatacccg gatattaaac agaagcatgt 347341 ctggattgat gtgaatgtga aggagcagaa ggcttacatc aaggaaggaa gcaacaccat 347401 ctatacaatg atgatttctt ctggtcttga tcaaacaaaa gatgatgcta cgccaaaggg 347461 caccttttat gtagagcctg aacggggaga atggtttttc tccgaaggat accaggaagg 347521 cgcagaatac tgggtatcat ggaaaaatca cggtgaattt ttatttcata gtgtgccaat 347581 gactaaggat caaaaagtca tcaaaacgga agcagaaaaa ctaggaacga aagcatctca 347641 cggatgtatc aggctgacca ttccagatgc gaaatgggta tatgaaaata tccctgaaca 347701 tacaaaagtg gtgatcagct gaattgaaaa ccgttgacaa aaaggaaaaa agaccataca 347761 atttaaatcg taacaattac gttttatgat aaatggctta tcattgtctg tgcatctgtg 347821 aaaagcggaa aggcatcgat taaggatctt gctgtcggca aaggcaagga tttgcgatgg 347881 ggaaaaggat taaacgcggt tggagtcttt actgatttag aaatcgggcg gcagcgagaa 347941 atgagcgcga aaagctgctc tacaccattg tacatacggc gaagtattca atttaaatcg 348001 taatcattct attttaatgg aggcactatt atgaaaaaaa ttccggttac cgtactgagc 348061 ggttatctcg gtgcgggaaa aacaacattg ctgaacagca ttttgcaaaa tcgcgaaggc 348121 ttgaaaatag cggttatcgt aaacgatatg agcgaggtga acattgacgc gggcttggtt 348181 aagcaggaag gtggcctttc cagaacagat gaaaagcttg tggaaatgtc aaatggctgc 348241 atttgctgca cgcttcgcga agacttatta attgaagttg agaagctggc aaaagacgga 348301 cggtttgatt atatcgtcat cgaatcgaca ggaatcagcg aaccgatccc ggtggcccag 348361 actttctctt atatcgatga agagatggga atcgatctta caaaattctg tcagctggat 348421 acgatggtga cggttgttga tgccaaccgt ttttggcatg attatcagtc aggcgaaagc 348481 cttctggacc gcaaagaagc attgggggaa aaggatgaaa gagaaatcgc cgacctcttg 348541 atcgatcaaa ttgagttttg cgatgtactg atcttaaata aatgtgattt ggtcagcgag 348601 caagagctcg aacagcttga aaacgttctt cgtaaactgc agccaagagc caggttcatt 348661 cgttccgtca aaggaaatgt aaaaccgcag gagattttgc atacagggtt atttaacttc 348721 gaggaagcga gcggatcggc cggctggatt caagagctga cggcaggcca tgcggaacac 348781 accccggaaa cagaagaata cggtatctct tcatttgtat ataagagacg tttgccgttt 348841 cattctacac gattttaccg ttggttggat caaatgccaa agaacgtggt acgtgccaaa 348901 ggaatcgtct ggtgcgcatc tcataacaac ctcgctttgc tgatgtcgca agcaggtccg 348961 tcggttacga ttgagcctgt atcttattgg gtggcggcgt tgccgaagct tgagcaggag 349021 caagtcaaac agcaggagcc ggaaatcctg gaggagtggg acccggagtt cggcgaccgc 349081 ctaacgcagc tagtttttat cggaactgac ctggatgaag aaacgatcac gaaagagctt 349141 gatcaatgcc tgttgactga gtatgaattt gattccgact ggtcgctgtt tgaggacccg 349201 tttaaatgga agctgaatca atagaaaaaa agccgtccca tggggaacgg ctttttttaa 349261 tgaaacgttt gtttaaacat aatgagcgta ttttttctca aggatattct gaaagaccgc 349321 ggcaatggag cagatggccc aataaatgag agcggtcaga atatacatgg tcatataatc 349381 aaactctctg cccccgatga ttttcgcatg ctggagcaat tccggcactg taatcatcgc 349441 agcgagagag gacgccttga tcaagtcgag caatacattg gcaagcggag gcagcgcaat 349501 acgtatcgat tgcggcaaaa tgatgcccct catcgtctgc caataggaaa gacccagcga 349561 ggatgcggct tcccactgtc ctttttcgac ggatgaaatg gctgaacggt taatttccgc 349621 aatgtaggcg gcgctgttta ggctaaagcc gattaaagca gccgtgacag cggaaaattc 349681 aatgccgata taaggaaacc cgaaataaag gataaacaaa atcaccaaaa tcggaacgcc 349741 tcgcataaat gagatataga gcttcgccgg ccatcttaac aaagcaagtt tagacattct 349801 ggcgagtgat atgaacaggc cgatcacagt tcccgcaaac atgcttacaa aagagatgag 349861 cagtgtataa ccaatgcctt ttatgacata agggaacgat tcaatggcca gcttcgtgtt 349921 gaaaatatat tcccactgaa tgctattgat catggcgtcc gattacaaat caacgtcctg 349981 aacgtcggca tcaatttttt ttgatacatc tgctttattg aagaattgtt tcgacagttt 350041 agtcaaagag ccatccttgc tcatctcttt caatgcttcg ttcatctttt tctgaagtgc 350101 cgcattgctt tttttcatga caagggcctg tttgttcggc atgtacttga tgtcaggatg 350161 aattgtaatg ttgagatccg ggaatgccgc gagcgcaagt gtctgcaggt aatagtcgtt 350221 taaaatgacg tcagtgcgtc cgttggcaac atcttttaaa tattgctcat tcgtcgcatt 350281 atcataaatc acttctttgg cgccgtattt tctcgcgacc tccatgtaga cggttgtagc 350341 cgcgccagcc gctttcttcc cttttaaatc cttgagcgtt ttaatccctg ataaatcgtc 350401 ttttcggaca attgccgtgc cgtatgaata tttatatgga gtggaaaatg cgaacttctc 350461 ctcacggtcc ttcgtcacat cgatgtcatt cgcggctgcg tcaacctgtc cgctgttcac 350521 cgctgtcagc atcccgtcaa tgcccatctc cttgaactca accttcagcc ccaagcgttt 350581 tgccgcttca cgaacaactt caacctcgta gcccgtcagc ttatcagagc cagagtcagt 350641 atcgtgataa gaagtgggat agagcgtacc tgatgtagcg actacgattt tccctttatc 350701 cttaatctgc tcccagcctg tatccttgga atcggcttca tttttgccgg aacaggctgc 350761 caatataaga aagaaagcca ttgtgaaact gaatataacg gctttggaat gcatgaatga 350821 tttcacctat agttccccca atctgttaat caactaaaaa gatagcattg aacataaggg 350881 gttgcaatat gttgatcgcg ttttcaaaaa gttcgaattg tgtatacaaa aagcatgggt 350941 gggtgtttaa aagcgtctat gaagggaaga ggtgatgaaa aaaggaattg tccaaggatg 351001 aatgccagac gtaccaagga aacgcatgtg aaagtgaagg atgcagcaga cccgtcactc 351061 atctatgcca ataccggaag aaatggtcaa gaggcatgaa accgatcttc agaataaatt 351121 taagtcttgc tgatgcccct aaggcatatg atatattcga tgagaaagaa aatggaaaca 351181 tttaaaccat aatggggagt caaatgaata tttacaaacc agccggattt tggatcagac 351241 ttggagctgc attgttagac tacattatag tctccgtgcc gcttttgctg atctattggc 351301 tgattacagg aaaagaccca aacgacagca tgttcatcag tttggttgtt ctgctgtatt 351361 ctattttgct gccgatgttt tggcgcggtt atcttatcgg aaaaaggatc tgcggaatca 351421 gaatcgtaaa aaaagacgga tcacaggtca gtctgttaac aatgttttta cgggttattg 351481 tagccggcct ggtttactgt ataaccttcg gactcggctt gatcgccagc ctgattctga 351541 ttgccgtacg agaagacaaa cggaccctgc atgatttaat cgcgggaaca tatgtcactt 351601 atgcgacacc aggtgaagag gaacttaatg ctgacgaaga gattagaaag agcgaataat 351661 ggttcgctct ttttattttt atgcataaaa aatacaaggc agcaaaacat atgaaaaata 351721 ggattggagg aataaaatgg atgaaacgaa taaccatcaa cattatcaca atgttcattg 351781 cagcggctgt catttctctg accggtacag ctgaggccgc tgaaaaacag cagcagtctc 351841 ccgcaaatgt tacactgaca gatcagcaaa agaaagagat tgaacaactg gaagcagaga 351901 ttcttaaaaa gcgcaaagac gtgatctcaa agtatgtaca atacggtatc ctgcctaaag 351961 aaagaggaga acacatcaaa aatcacttgg acaaacactt tgaaatgatg aaacaaaacg 352021 gctttgttcc aaagcaccat cctcatccgc ataaatttga aaaaagacat taagatttta 352081 agcatccaat gggaattggg tgcttttgcg ttatttacag gtaggcaata ttagctgagc 352141 tgttccgcga ctaacatcga gttgatatga aacgcgtttc atagcctatg ataggtttat 352201 caaataattc aggagtgata aacactatga tccaccagca tccagaatct tttccgaaac 352261 attttttgtg gggctctgct tctgcagcgt accagattga aggcgcttgg aatgaagatg 352321 gcaaaggccc ttctgtttgg gatgtgttta cgaaaatacc gggcaaaacg tttaaaggaa 352381 ccaatggcga gattgcggtt gaccattatc accgatttaa agaagatgtc gctctgatgg 352441 ctgagatggg gttaaaagca tatcgatttt ccgtcagctg gccacgggtt tttccaaaag 352501 gaaaaggaga gatcaatgaa gcaggtctag cgttttacga tagtctgatt gatgaattgc 352561 tttctcatca catcgagccg gttctgactt tatatcactg ggatttgcct caagcgctta 352621 tggacgaata cggcgggttt gaatccagaa acatcataga ggattttaat cactactgta 352681 ttactcttta taaacgtttt ggagacaggg tgaaatattg ggttacgtta aacgaacaga 352741 actacaattt taatcacgga tttattacag ccatgcatcc gcctggagtg aaagacagaa 352801 aacgatttta cgaagcaaac catattgcgt ttctggctaa tgcaaaagcc atcgaatcat 352861 ttagagaata tgtgcctgaa ggcaaaatag gtcctagctt tgcttattct ccggcttacc 352921 ctttatcaag tcatccagag gatatactgg catttgaaaa cgccgaagaa tttacgaaca 352981 attggtggct tgacatgtat tgctggggaa cctacccgca aattccattc cgctgcttgg 353041 aaaaacaggg atgggcgccg acaattgaag caggagatat ggacctgctc gccaaaggga 353101 agcctgattt tgtaggtgtc aattattatc agacgatcac ctatgaacga aatccgcttg 353161 atggtgtgtc agaagggaaa atgaatacga caggccaaaa gggaaccaat caggagacgg 353221 ggatacccgg agtgttcaaa acgaaaaaaa atccgcatct gacaacgagc aactgggatt 353281 ggacaattga cccaattggg ctgcgtatcg gtcttcgccg aattacaagc cgctatcagc 353341 ttccagtgtt tataacagag aacggtttgg gtgaatttga taaagttgag gacggcactg 353401 tacaggatga ttatcgaatt gattatttgc gttcgcatct tgagcaatgc agacaagcca 353461 tcagtgacgg tgtcgattta atcggctatt gcagctggtc gtttactgat ctgttaagct 353521 ggctgaacgg ctaccaaaaa agatacggat ttgtatatgt caatcgtgat gaagaaagca 353581 catccgattt aaaacgcttg aagaaaaaaa gcttttattg gtatcaagat gtcatcaaga 353641 caaacggaga aagtttataa agagtccctg agagttattc tctcaggggt ttttcattac 353701 acagaaacag catcaataat ataagtgtcg gcgtgcaaat ctgacatttc agccggcaca 353761 gtccagcatg tcaattgata gtctccttta ggcagatcaa aggacagtct tttagacatg 353821 atgctttcaa tatgaattcc gttttctgtg acatgaaaag gaacagtcac ttttttttcg 353881 taggagttta ctgtttctga actgttcagg cgaaaaagaa taaaggcctt tgtatttcgc 353941 tgtgcctcaa aggaaatggc tccgtctgcc gcagcatatc ctttttcaat cgcttcgtca 354001 gtccaatcca ttacaggagg tgtagaatcc ttttgaaata cagtaaattg atgatatgaa 354061 atcgaaagtt cttgcggctt ccatgatttg atcaatgtgc tgttcctcct ctatgtactg 354121 tttactgaat tgtgaataaa acctttgtgc cgtctgggta atcggtaagc cgatgcccga 354181 cccaagagcc tgctccgcgg ttgtcagcgg gagaaatgta ttctacagaa gctccctcac 354241 cgccttcttt gcacatggcc attggccatt catctctgtc ataccccttt ttggaaggta 354301 cgtcctttaa tgattgctcg cggcgttctt cagctccgtc tctgtcaata gtgcacacct 354361 ctgagtgccc ctcatttatc gcatccttaa tatgcttggc agtttcggga taccggtcag 354421 atgggaaggc cattgtttca tcatattctt tcgtttgaga cgttttttga tcagctgaga 354481 aaaagtctcc ttttatcagg ccgacagctg cagctgctat gatgacgatg acgagaagta 354541 tcgtttttat gatgtccgtc gtgatgttca cctcccgctt ttaaaactga cacaagagta 354601 atccagaaag catttggtgt aaaggtttaa attttatgtt ttacgatcag tttattgcag 354661 aaatcgtaat tttagcagat cgaaatattt gttttcagca aaatacgatt gccaatttac 354721 aataatgata gtaagtcatc agccgttttc ggcttgatta atcattttaa attggcttat 354781 gataccggta agctcctcag ctaattgaga aagtgtttca gaagctgcgg taatctcctc 354841 cattgcagca aattgctcct ctgttaatgc agccgcttgc cgggtatttt tagtagattc 354901 tttaatgtcg gccgtattgg ctgcaaagga atcatttatt tgatgtgcac tggctgaaat 354961 gtttgttaca gatgctgata aatcactaat ctcggcgctg atttcacctg ttgcagctgc 355021 aatttcctta aatgcatctc tggtgcgctg gatcatggtg actccttctg cagcttctgt 355081 tttcacatgc tcaacagatc ttgcagaccg gttcatatcc ttttgtattt ctatgatcag 355141 ttttgaaatc tgccccgcag actgttgaga ctcttctgct aatttccgta cttcatcagc 355201 aacaacagca aagccttttc cttgttcacc ggctctggca gcttcaatcg ctgcattcag 355261 cgcaagcagg tttgtctgat cagcaatttg ggtgatgacc gataaaattt gctcaatttg 355321 tttagagcgg ccgtctaact ggtgtatgat ttctccgctt ttctgaattg actggtgaat 355381 cgcatccatt tgcgcctgta catttgcaat ttccttttgt ccaatgtctg cttttgattg 355441 agcgagctgc cctttgtcag cgatagcggc agtatttgca gaaatatccc ggatgtctgc 355501 tgaagcttgt tttaatgagc tttcactatt ttcaattcgg gtgatctgat cttgggctcc 355561 atttgcaatc tgctgtacag cttctgtgat tttttctgaa gcttgatttg tttcctctgc 355621 tccggctgag agctgctgag aggctgacgc aagctgaagg gctgattgtt gtacggtttg 355681 tatggtatcg ttcagcttca ttctcatctt attataatag acgcttagtt ctgaaagctc 355741 gtcaccggtt ttgtctgaca cctctattgt catatctccg tttccggcac tttcaaaggc 355801 gctttttaaa gcgttcagcc gcttgttgat ttttctggtg aaaaccaaga caaggatgac 355861 tgataccata atgacgataa caagaacgat agcgaattga gtgaaaagtg attgtgtaag 355921 tgatgctaaa atactttgat tagctccggt atacagcatg ccgatgatgt tcccattttg 355981 atcttttaac ggcatgtatg cagtctgata agaagaacct gctacatctg cttgtccgta 356041 aaaacgcttt cctttcttta aaacagcggc aataacttca gaagaagcct gggtgccgac 356101 ggctctttcg ccatttttca tgacattggt tgcaacacga gtatcgcctt ggaaaatggt 356161 aatggtatca cctgtctttt caccaagcag atcaacaata tcttcatttc cattgatttg 356221 tgtttgccct ttatagagct tattgttttt cacctgccag tcgcctgaca tgacatcatc 356281 aatataagtg ctgcttaaag cgagatcacc tttcgctttt tcagttgcca tttgtttcat 356341 gctttctgta atttccttaa gcatcacagt gccaactgat gccgaaaaca aaagaatcac 356401 cacgaaaacg aggcaaagaa ttttagttcc tagcttcatc ttaaatcgtt ttatcaacat 356461 aattcctccc tttacgattt gcaggtcata ttacttatcg ggtttttggg tttaaagttt 356521 tattttagaa aaaataaaac cggcctgatc ttcaggccgg ttgtgtgatg ctattcaagg 356581 tttgcgtggt gagtgaacat agtttcagaa tcgagacctt ttttctccat gagttttaaa 356641 atcactgcat catagaagag cagcaaagtt tgttcaaata atgatcccat tggctgaatg 356701 gttttatagc ttccgttaga ctggtcttta ggggaaccag gcattctgat gatgaggtcc 356761 gcttgttttc cgatgcttga ttccggattg atggttaaag cggcaacaat tccgtgtaag 356821 ctttttgctt ttgctgcggt atgaatcaag ctctttgtct cgcctgatcc tgagccgata 356881 ataactagat ctccttcggc gagcggcgga gtgagaatct cacctactat atgggcgttg 356941 aagcccatgt gcatcagtct catcgcgaag gattttgcca tcaggccaga ccgccccgca 357001 cccgcggtga aaatttggtg ggatgaaaga atgtgatcgg caagctggtc agcttcttca 357061 ttagaaatat aagctgctga attgtgtaac tcattgagaa tttccgctac gtattcagtc 357121 gttttcatcg gagttatcct tggacaatca gctgcttcat ttttgaagct gtttccgcct 357181 tatcagctgc gcttgtaatt ccgcccccga caatgacaag gtcaggcttt tgctggatca 357241 cttctggcag tgtatcaagt ttgatgccgc ccgcgattgc ggtttttgcg ttttttacgg 357301 tatttttgat tgtcgttaat tcttcgaaag agtttttgcc ctctgcttga agatcatagc 357361 cagtgtggac gcagatgtag tcaacaccga gtgcgtcaat ttctttcgca cgggattcga 357421 tatctttcac gttaatcatg tccactaaga ttttcttctt ttgttttttg gcttcttcta 357481 ctgcgccttt aatcgttgca tcgtctgtag cccctaaaac ggtgatgatg tcagcgcctg 357541 cttccgacgc tttcataatt tcgtagcctc cggcatccat gattttcagg tctgcaagaa 357601 ccttcaattg aggaaatgct tcttttattt ctttaacggc tcttaggcct tcattgatga 357661 cgaccggtgt tccgatttca actacgtcga tgtattgttc tacctctttg acaagctcaa 357721 tggcttccgg gatgttgacg aggtctaatg caagctgtaa ttccattgtt gatccactcc 357781 ctttttcgaa ttattgttca ttctataggt tccttctttt gttgagaagt aggcactttg 357841 aagtcaacaa gttacttgga ggatactgtg aggagagaca atcagatttc tttcgcttga 357901 ttttatgagt gagtataatg aaaaaagagt ctgcaaaaaa gtaagtaagt gatgatacgt 357961 atctaacata caaaaaggtt actaaggggg gggattctat tgagccggat ggacgacaaa 358021 aggtttaatt gtgagaagga attaacgctt gcagtgattg gcggtaaatg gaaaatgctc 358081 attttatggc atttaggaaa agaaggcaca aaacggttca atgaattaaa aacattgatt 358141 cctgatatta cgcagaagat cctcgtgaat cagctgagag agcttgagca ggatatgatt 358201 gttcacaggg aagtgtatcc agttgtcccg ccgaaggttg aatattctct gaccccgcac 358261 ggagaaagcc tcatgcctat tcttgaagcc atgtatgagt gggggaaagg ctatatggaa 358321 ttgattgata tcgacaaaaa tgtcatgaaa gaatcgttgt aagacgctct tcgcaagggt 358381 gtcttttttt gccttttttt cggtttttgc gcggtacaca tagtcatgta aagattgtaa 358441 attgcattca gcaataaaaa aagattgaac gcagcagttt ggtttaaaaa tttttatttt 358501 tctgtaaata atgtttagtg gaaatgattg cggcatcccg caaaaaatat tgctgtaaat 358561 aaactggaat ctttcggcat cccgcatgaa acttttcacc catttttcgg tgataaaaac 358621 atttttttca tttaaactga acggtagaaa gataaaaaat attgaaaaca atgaataaat 358681 agccaaaatt ggtttcttat tagggtgggg tcttgcggtc tttatccgct tatgttaaac 358741 gccgcaatgc tgactgacgg cagcctgctt taatagcggc catctgtttt ttgattggaa 358801 gcactgcttt ttaagtgtag tactttgggc tatttcggct gttagttcat aagaattaaa 358861 agctgatatg gataagaaag agaaaatgcg ttgcacatgt tcactgctta taaagattag 358921 gggaggtatg acaatatgga aataactttt taccctttaa cggatgcaca aaaacgaatt 358981 tggtacacag aaaaatttta tcctcacacg agcatttcaa atcttgcggg gattggtaag 359041 ctggtttcag ctgatgcgat tgattatgtg cttgttgagc aggcgattca agagtttatt 359101 cgcagaaatg acgccatgcg ccttcggttg cggctagatg aaaacgggga gcctgttcaa 359161 tatattagcg agtatcggcc tgttgatata aaacatactg acactactga agatccgaat 359221 gcgatagagt ttatttcaca atggagccgg gaggaaacga agaaaccttt gccgctatac 359281 gattgtgatt tgttccgttt ttccttgttc accataaagg aaaatgaagt gtggttttac 359341 gcaaatgttc atcacgtgat ttctgatggt atctccatga atattctcgg gaatgcgatc 359401 atgcacattt atttagaatt agccagcggc tcagagacaa aagaaggaat ctcgcattca 359461 tttatcgatc atgttttatc tgaacaggaa tatgctcaat cgaagcggtt tgaaaaggac 359521 aaggcgtttt ggaacaaaca atttgaatcg gtgcctgaac ttgtttcctt gaaacggaat 359581 gcatccgcag ggggaagttt agatgctgag aggttctcta aagatgtgcc tgaagcgctt 359641 catcagcaga ttctgtcgtt ttgtgaggcg aataaagtca gtgttctttc ggtatttcaa 359701 tcgctgctcg ccgcctattt gtacagggtc agcggccaga atgatgttgt gacgggaaca 359761 tttatgggca accggacaaa tgcgaaagag aagcagatgc ttggcatgtt tgtttctacg 359821 gttccgcttc ggacaaacat tgacggcggg caggcgtttt cagaatttgt caaagaccgg 359881 atgaaggatc tgatgaagac acttcgccac caaaagtatc cgtataatct cctaatcaac 359941 gatttgcgtg aaacaaagag ctctctgacc aagctgttca cggtttctct tgaatatcaa 360001 gtgatgcagt ggcagaaaga agaggatctt gcctttttga ctgagccgat tttcagcggc 360061 agcggattaa atgatgtctc aattcatgta aaggatcgat gggatactgg gaaactcacc 360121 atagattttg attaccgcac tgatttattt tcacgtgaag aaatcaacat gatttgtgag 360181 cgcatgatta ccatgctgga gaacgcgtta acgcatccag aacatacaat tgatgaatta 360241 acactgattt ctgatgcgga gaaagagaag ctgcttgcga gggccggcgg taaatctgtg 360301 agctaccgta aggacatgac gataccagag ctgttccaag aaaaggctga actgctttct 360361 gatcatccag cggttgtatt tgaagatcgc acattgtcct atcgaacgtt acatgagcaa 360421 tctgcacgca tcgccaatgt gctgaaacag aaaggggttg gcccggacag tcctgtcgcg 360481 gttttgattg aacgctctga acggatgatt acagctatca tgggaatttt aaaagccggc 360541 ggagcctatg tgccgattga tccgggtttt cctgctgagc gcattcaata tattttggag 360601 gactgcgggg cggatttcat cctgactgaa tcgaaggttg cggcgcctga agccgatgct 360661 gagctgattg acttagatca ggcgattgag gaaggtgcag aagaaagcct gaatgcagat 360721 gtgaacgctc ggaaccttgc ctacattatt tacacatcgg gaacaaccgg acgcccgaaa 360781 ggcgttatga tcgagcatcg ccaggttcat catttggttg aatctctgca gcagacgatt 360841 tatcaaagcg gcagccaaac cctgcggatg gcattgcttg cgccgttcca ctttgatgcg 360901 tcagtgaagc agatcttcgc gtcgcttctt ttgggccaaa ccctttatat cgtaccgaag 360961 aaaacagtga cgaacggggc cgcccttact gcatattatc ggaagaacag cattgaggcg 361021 acggacggaa caccggctca tttgcaaatg ctggcagcag caggcgattt tgaaggccta 361081 aaactgaagc acatgctgat cggaggagaa ggcctgtcat ctgttgttgc ggacaagctg 361141 ctgaagctgt ttaaagaagc cggcacagcg ccgcgtttga ctaatgtgta cgggccgact 361201 gaaacgtgcg ttgacgcgtc tgttcatccg gttatccctg agaatgcagt tcaatcagcg 361261 tatgtgccga tcgggaaagc gctggggaat aaccgcttat atattttgga tcaaaaaggc 361321 cggctgcagc ctgaaggcgt ggcgggtgag ctttatatcg cgggagacgg tgtgggccga 361381 ggctatttac atttgcctga attaacggaa gagaagtttt tacaagatcc attcgtgccg 361441 ggcgatcgca tgtaccggac cggggacgtg gtgcgctggc ttccagatgg aacaatcgaa 361501 tatttaggca gagaggatga ccaggtcaaa gtccgcggat accggattga gcttggggaa 361561 attgaagccg tgattcagca ggcgccagac gttgcaaaag ccgttgtttt ggcacgccct 361621 gacgaacagg gaaatcttga ggtttgcgca tatgttgtgc agaagcctgg aagcgaattt 361681 gcgccagccg gtttgaggga gcatgcggcc agacagcttc ctgactatat ggtgccggct 361741 tactttacag aagtgacaga aattccgctt acaccaagcg gcaaagtcga ccgccgcaag 361801 ctgtttgcac tagaggtgaa ggctgtcagc ggcactgcct atacagcgcc gcgaaatgag 361861 actgaaaaag caatcgcagc catttggcag gacgtgctga acgttgagaa ggcggggatc 361921 tttgacaatt tctttgaaac tggcggacat tcattaaaag ccatgaccct tttaacaaag 361981 attcataagg aaacaggcat tgagattccg cttcaatttt tgtttgagca tccgacgatt 362041 acggctcttg cagaggaagc tgatcacaga gaaagcaaag cttttgcggt gattgaacct 362101 gctgaaaaac aggagcatta cccgctttca ttggcacagc agcgaacata tatcgtcagc 362161 cagttcgagg atgcgggagt cggctataac atgccagcag cagcaattct ggaagggcct 362221 ttagatattc aaaagctgga gcgcgcattt cagggattaa tccgacgcca cgagtcattg 362281 agaacatcat ttgttcttga aaacagcacg ccgagacaga aaattcacga tagcgttgat 362341 ttcaacatcg aaatgattga aagaggcggc cgctcagatg aggcaattat ggcttcattc 362401 gttcggacat ttgatttggc gaaagctccg ctgttcagaa tcggtttgct ggggcttgaa 362461 gagaaccgtc atatgctgct gtttgacatg caccatttga tttctgacgg tgtatccatt 362521 ggcattatgc tggaggagtt agcacgcatt tataaaggcg aacagcttcc tgatcttcgt 362581 ctccagtata aggactacgc tgtatggcaa agcagacagg ctgctgaagg gtacaagaag 362641 gaccaggctt attggaagga agtctttgca ggcgagctcc cggtgcttca gcttctgtcc 362701 gattacccaa gaccacctgt tcaaagcttt gaaggggatc gggtgtcaat caagctggat 362761 gcgggggtaa aggatcgcct caatcgtttg gctgaacaaa acggcgccac tttatatatg 362821 gtgatgcttt ccgcttacta tacgcttttg tcaaagtata cggggcagga tgacatcatt 362881 gtcgggacac cgtcagcggg cagaaatcac tccgatacag agggcattat cgggatgttc 362941 gtcaatacgc ttgcgattcg cagtgaggtg aagcagaatg agacgtttac ccaattgatc 363001 tcgcgtgtcc gcaaacgggt gctggatgcc ttttctcatc aggactatcc gtttgagtgg 363061 cttgttgaag atttgaacat cccgcgtgat gttagcaggc atccgctgtt tgacacgatg 363121 ttcagccttc aaaacgcgac agagggcatt ccggctgtcg gcgatctttc cttgtctgtt 363181 caagagacca atttcaagat tgccaaattt gatttgacgg tgcaggcgag agaaaccgat 363241 gaaggcattg agattgatgt ggattacagc acaaagctgt ttaaacaaag cacggcagac 363301 aggctgctta cgcattttgc gcgtttgctt gaagatgctg cggctgatcc agagaagccg 363361 atttctgagt ataagcttct ttctgaagag gaggctgctt cgcaaattca gcagtttaac 363421 ccgggcagaa caccttatcc gaaagataaa acaattgttc agctgtttga ggagcaagcg 363481 gcgaatacgc cagaccacac tgcgcttcaa tatgaaggcg aatcactcac ttatcgtgaa 363541 ctgaatgaac gggccaatcg tttagcccgc ggcattcttt ctcttggagc tggcgaaggc 363601 agaactgcgg ctgtcttatg cgagcggtca atggatatga ttgtgtcgat cttggcagta 363661 ttaaaatcag gttcggctta tgttccgatc gatccggaac atccgattca gcggatgcag 363721 catttcttcc gtgacagcgg agcaaaggtg cttctcactc agaggaaatt aaaggctttg 363781 gcggaagaag cggaatttaa gggcgttatc gtgctagccg atgaggaaga aagctatcat 363841 gccgatgcgc gaaatctcgc actgcctctt gattctgcag caatggccaa cctgacgtat 363901 acttccggaa cgactggaac acctaagggg aatatcgtga cacatgccaa tattctccgc 363961 acggtgaagg aaacgaatta tctcagcatt acagaacagg atacgattct cggtctttcc 364021 aattacgtgt ttgacgcgtt tatgttcgat atgttcggct ctttgttaaa cggagccaag 364081 ctggtgctga taccgaagga aaccgttttg gacatggctc gcctgtcccg cgtcattgaa 364141 cgggagaaca tcagcattct catgattaca accgctttgt tccacttgct tgtggacttg 364201 aatccggcat gcttgtcaac gcttcgcaag attatgtttg gcggggaacg ggcttcggtt 364261 gagcatgtca gaaaagcttt gcaaacggtt ggaaagggca agctccttca tatgtatgga 364321 ccgtctgaaa gcacggtttt cgcgacgtat catccggttg atgaattgga ggagcacacg 364381 ctgtctgttc cgattggaaa accggtcagc aatacggaag tatacattct tgaccgtacg 364441 ggacacgtgc agcctgccgg gattgccgga gagctttgcg tcagcggcga aggactcgtg 364501 aaaggctatt acaaccgtcc agaactgact gaggagaaat ttgttcccca tccgtttaca 364561 tccggcgaac gcatgtataa aacgggagac cttgcgagat ggctgccgaa tggcgacatc 364621 gaatttatcg ggcgaatcga ccatcaggtg aagattcgcg gacagcgcat cgagcttgga 364681 gaaatcgaac atcagctgca aacccatgat cgtgttcagg aaagtgttgt gcttgccgtt 364741 gatcaaggag cgggagataa actgttgtgt gcttactatg tcggagaagg agacatctca 364801 tcacaagaga tgagagagca tgctgcgaag gacttgccgg catatatggt tcctgcggtg 364861 tttatccaaa tggacgagct gccgctgaca gggaacggaa aaattgaccg gagagcgctg 364921 ccgattcctg atgccaacgt ttcaagaggt gtttcatatg ttgcgccacg caatggaacg 364981 gaacaaaaag tcgcggacat ttgggcacag gtacttcagg cagaacaagt cggcgcttat 365041 gaccacttct ttgacattgg cggacattca ttagcaggca tgaagatgct tgccttggtt 365101 catcaggaac tgggcgttga gctgtcactc aaggatctct tccagtcacc gacggttgag 365161 ggcttggcac aggtgattgc ctctgctgaa aaagggacag ccgcaagtat cagcccggca 365221 gagaaacaag atacgtatcc tgtttcttca ccgcaaaaac ggatgtacgt gcttcagcag 365281 cttgaggatg cgcaaacgag ctataacatg ccggcggttc tgcgcctgac aggtgagctt 365341 gatgttgaaa ggcttaacag cgtcatgcag cagttaatgc agcgtcatga agccttgaga 365401 accacgtttg aaataaaaga tggagaaacg gtgcagcgga tctgggaaga ggctgagtgc 365461 gagatagcct atttcgaagc cccggaagaa gagacagagc ggatcgtttc tgagtttatt 365521 aagcctttca aaatcgacca acttccactg ttcagaatag ggcttatcaa gcattcagac 365581 actgagcatg tgctgctgtt cgatatgcat catattattt ctgatggtgc atctgtcggt 365641 gtgctgattg aggagctttc aaagctgtac gacggagaaa cccttgagcc gctccgtatt 365701 caatataagg attatgccgt gtggcagcag cagttcattc agtctgagct ttacaagaag 365761 caagaagagc attggctgaa ggagctggac ggagagctgc cggtgctgac gcttccgact 365821 gattacagtc ggcctgccgt tcaaacattt gagggagacc gcattgcatt ttcattagaa 365881 gcaggcaaag ctgatgctct gcgcaggctt gcaaaagaaa cggattccac gctttacatg 365941 gtgcttctgg cttcatacag tgcgttttta tcaaaaatta gcgggcaaga cgatatcatc 366001 gtcggttcac ctgtggccgg acgatctcaa gcggacgtca gccgcgtcat cggaatgttc 366061 gtcaatacat tggcgctgcg cacgtatccg aagggtgaaa agacgtttgc tgactatctt 366121 aacgaagtga aagaaacggc actcagcgct tttgatgcgc aggattaccc acttgaggat 366181 ttgatcggaa atgttcaggt tcagcgtgac acaagcagaa atccgttatt cgatgcagtt 366241 ttttcaatgc aaaatgcgaa tataaaggat ttaacaatga aagggattca gcttgagccg 366301 catccgtttg aacggaaaac agccaagttt gacctcacgc tgacggctga cgaaaccgac 366361 ggagggctta cattcgtact cgaatacaat acagctctgt ttaagcagga aacgattgaa 366421 cgatggaagc aatattggat ggagctttta gatgcagtta ctgggaaccc gaaccagccg 366481 ctttccagcc tgtcactggt caccgagaca gaaaagcaag cgcttcttga ggcatggaag 366541 ggcaaagcgc tgcctgtgcc gacagacaaa acggttcatc agctattcga agagactgcc 366601 cagcgccaca aagaccgccc ggctgtcaca tacaacggcc agtcttggac gtacggcgag 366661 ctgaatgcga aggcaaaccg tctcgcgcgg attctgatgg actgcggcat cagcccggat 366721 gaccgcgtcg gcgttctcac gaagccgtcg cttgaaatgt ccgccgcggt gctcggcgtc 366781 ttgaaagccg gagcggcgtt tgtgccgatt gatcctgact atccggatca gcggattgag 366841 tatattttac aggacagcgg cgcgaagctt ctcttgaaac aggaaggcat ttcagtgccg 366901 gacagctata cgggagatgt cattcttctc gacggaagcc gcacgattct aagcctgccg 366961 cttgatgaaa acgacgagga aaatccagaa accgctgtaa ccgcggagaa cttggcgtac 367021 atgatttaca cgtctggaac gaccggacag ccgaagggtg tcatggtcga gcaccatgcg 367081 cttgtgaacc tgtgcttctg gcaccacgac gcgttcagca tgacagcgga ggaccgcagt 367141 gcgaagtacg cgggctttgg gttcgacgct tccatttggg agatgttccc gacctggacg 367201 atcggtgccg aacttcacgt cattgaggaa gcgatccgcc tcgatatcgt ccgcctgaac 367261 gattattttg aaacgaacgg cgtaacgatc acgttcctgc cgacacagct tgcggaacag 367321 ttcatggagc ttgagaacac atcacttcgc gtattgctta ctggaggaga caagctgaag 367381 cgcgcagtga aaaagccgta cacactcgtc aataactacg ggccgacaga gaatacggtc 367441 gttgccacaa gcgcagaaat ccatccggag gaaggctcgc tttccatcgg aagggccatt 367501 gccaatacga gagtatacat tctcggcgag ggcaatcagg tgcagccgga aggcgtagcc 367561 ggagagcttt gcgtggcggg gcgcggactg gcacgcggct atctgaatcg agaagacgaa 367621 accgcgaagc ggtttgtcgc tgatccgttt gtgccgggtg agcgcatgta ccgcaccggc 367681 gatttggtga aatggacggg cggcggcatc gaatacatcg gccggatcga ccagcaggtc 367741 aaggtccgcg gctaccggat cgagctctca gaaattgaag tccagctcgc ccagctttct 367801 gaggtgcagg atgcggcggt gacagctgtc aaagataaag gcggcaacac agcgatcgcg 367861 gcgtatgtca caccggaatc agctgacata gaagcactga aatcagcact gaaggaaacc 367921 ctgccggatt acatgatccc ggcgttctgg gtgacgctga acgagcttcc ggttacggca 367981 aacggcaaag tggaccgcaa agccttgcct gagccggaca tcgaagcggg aagcggagaa 368041 tacaaagcgc cgacgaccga catggaagag ctgcttgccg gcatctggca ggacgtgctt 368101 ggaatgtctg aagtcggtgt caccgacaat ttcttctcgc ttggcggaga ttccatcaaa 368161 ggaattcaaa tggcgagccg cttgaaccag cacggctgga agctggaaat gaaagatctc 368221 ttccagcacc cgacgatcga agagctcacc cagtacgtag agcgtgccga aggcaaacag 368281 gcagaccaag gcccggtgga gggcgaagtc atcctgacgc cgatccagcg ctggttcttt 368341 gaaaagaact tcacgaacaa gcaccactgg aaccaatctg tgatgcttca cgccaagaag 368401 ggctttgatc ctgaacgggt ggagaaaaca ttgcaggcgc tgatcgagca tcatgacgcg 368461 ctccgcatgg tctatcgtga gggacaggaa gacgtcattc aatacaacag aggtcttgaa 368521 gctgcttcag ctcaattgga ggtcatccag attgagggcc aagctgcaga ttacgaagac 368581 cgaatagaga gagaagcgga gcgtttgcaa agcagcatcg acttgcagga aggcggcttg 368641 ttaaaagcag gcttgttcca agcggaagac ggagatcact tgcttcttgc cattcaccac 368701 ttagtggttg acggcgtgtc gtggcggatt ttactggagg atttcgccgc ggtatataca 368761 cagcttgagc aaggcaatga accggttctc ccgcagaaaa cacattcatt tgcagagtat 368821 gcagagagat tgcaagactt cgcgaactcc aaagcctttt tgaaagaaaa agagtattgg 368881 agacagcttg aagaacaagc tgttgcggca aagcttccga aagaccgcga atctggtgat 368941 cagcgaatga aacatacaaa gacaattgaa ttctcgctga ctgctgaaga gacagaacag 369001 ctcaccacaa aggtgcatga ggcatatcac acagaaatga atgatatttt gctgacggca 369061 ttcggattgg caatgaagga gtggacgggt caagatcgag taagtgttca tttagagggg 369121 catggacgtg aagaaatcat agaagacctg accatttctc gcacagtcgg ctggtttaca 369181 agtatgtacc caatggtgct cgatatgaag catgcggatg atctgggcta ccagctgaag 369241 caaatgaaag aagatatcag acatgtgccg aataagggag tcggatacgg cattctgcgc 369301 tatctgacgg caccggaaca taaagaagat gtggcgttct cgattcagcc ggatgtcagc 369361 ttcaactatt taggtcagtt tgacgaaatg tcggatgcag gtttgtttac gagatcagag 369421 ctgccatcag gacagtcatt aagccctgaa acagaaaaac cgaatgcgct ggatgttgtc 369481 ggatatatcg aaaacggaaa actgacgatg tcactggcct atcattctct tgaatttcat 369541 gaaaaaacag tacaaacatt cagtgacagc tttaaagcgc atcttctcag aatcattgaa 369601 cattgcctat ctcaagatgg tacggaactg accccgagtg atcttggtga cgacgatttg 369661 acgctggatg agctggataa attaatggaa attttctaat agaggtggca tatgagcaaa 369721 aaatcgattc aaaaggtgta cgcactgaca ccaatgcagg agggaatgct gtatcatgcg 369781 atgcttgatc cgcattcttc ctcgtacttc acacaattag agcttgggat tcacggcgct 369841 tttgatcttg aaatctttga gaaaagcgtc aatgaactga ttcggtcata cgatattctc 369901 cgtacggtat ttgtgcatca gcagctgcaa aaaccgcgtc aggtcgtgtt agcggaacgc 369961 aaaacaaaag tgcattatga ggatatcagt catgcagacg aaaaccgcca gaaagagcac 370021 attgagcgtt acaaacaaga cgttcagcgc caaggcttta acctggcaaa agacatattg 370081 ttcaaggtag cggttttccg ccttgctgca gatcagctgt atcttgtctg gagcaatcat 370141 catattatga tggacggctg gagcatgggc gtcctcatga aaagcctgtt ccaaaactat 370201 gaagcgctca gagcaggcag gacaccggca aacggtcagg gcaagcctta ttccgattac 370261 atcaagtggc ttggaaaaca ggacaatgaa gaagcggaga gctactggag cgagcgcttg 370321 gcgggttttg aacagccaag cgtgctcccg ggccgcctgc ctgtgaaaaa agacgaatac 370381 gtcaataaag aatattcatt tacatgggac gaaacactgg ttgcccgtat tcagcaaacc 370441 gcaaatctcc atcaagtgac agggcctaac ctatttcagg ccgtttgggg cattgttctc 370501 agcaaataca actttacgga tgatgtgatc ttcggaacgg tcgtctcggg acgaccgtct 370561 gaaatcaacg gaatcgaaac gatggcgggg ctgtttatca acaccattcc agtgcgggtg 370621 aaagttgaac gagatgctgc attcgctgat attttcacag ctgttcagca gcatgcagta 370681 gaggcagagc gttacgatta cgtgccgctc tatgagattc aaaaacgctc agctcttgat 370741 ggcaatctct taaaccatct ggtcgcgttt gaaaattatc cgcttgatca agagcttgaa 370801 aacggcagca tggaagaccg cctcgggttt tcgattaagg tagaaagcgc atttgaacaa 370861 acgagcttcg atttcaacct gattgtgtat ccgggcaaaa cgtggaccgt caaaattaaa 370921 tataacggag ccgcctttga ttccgctttt atcgaacgga cagcggagca ccttacccgc 370981 atgatggaag cagctgtcga tcagccggcc gcttttgtgc gtgagtacgg gcttgtggga 371041 gacgaagagc agcggcaaat tgtcgaggtg tttaacagca cgaaagccga actccctgaa 371101 ggaatggctg ttcaccaagt gtttgaagag caagcgaaac ggacgccggc gagcaccgcc 371161 gtcgtatatg aaggaaccaa gctgacgtac cgcgagctga atgcagcggc taaccgtctg 371221 gcgagaaagc ttgtcgaaca tgggcttcaa aaaggggaaa cagcagcgat tatgaacgac 371281 cgctcagtag aaaccgttgt cggcatgctg gctgttttaa aagcaggcgc cgcatatgtg 371341 ccgcttgatc cagcgcttcc tggggatcgt cttcgtttca tggcagagga cagctccgtt 371401 cgaatggttt tgatcggaaa ttcttataca gggcaggcac atcagctgca agtgccggtt 371461 cttacactgg acataggctt tgaagagagt gaagcggctg acaatctcaa cctgccatcc 371521 gccccgtctg atttggcgta catcatgtac acatccggtt caacgggcaa accgaaaggc 371581 gtcatgatcg aacataaaag cattctgcgc ctcgtcaaaa atgccgggta cgttcctgtt 371641 actgaagaag accgcatggc gcaaacggga gctgtcagct ttgatgccgg aacgtttgag 371701 gtattcggcg cactgctgaa tggcgcagca ctttatccgg tcaaaaaaga gacactgctt 371761 gatgcgaaac aatttgctgc attcctgcgt gagcaaagca tcacaactat gtggctgaca 371821 tcacctttat tcaaccagct tgctgcaaag gatgcgggta tgttcggcac actgcgccat 371881 ttaatcatcg gcggagatgc ccttgtcccg catattgtca gcaaagtaaa acaggcatcg 371941 ccgtcgcttt cattgtggaa cggatacggc ccgacagaaa acacgacgtt ttcaaccagt 372001 tttctgatcg accgcgagta tggcggctct atcccaatcg ggaagccgat cggaaattcc 372061 actgcctata ttatggatga gcagcaatgc ctgcagccaa tcggcgcgcc tggtgagctt 372121 tgcgtaggcg gaatcggtgt agcgcgtggg tatgtcaatc tccctgagct gacggagaag 372181 caatttctgg aagacccgtt cagaccgggt gagagaattt accgcactgg tgacttggca 372241 agatggctgc cggacggcaa tatcgaattt ttaggcagaa tcgacaacca agtgaaggtg 372301 cgcggcttcc gaattgagct tggcgaaatt gaaacaaaac tgaacatggc tgagcatgtg 372361 acagaagccg cggtgatcat acgcaagaac aaagcagacg aaaatgaaat ttgcgcgtac 372421 ttcacggcgg atcgtgaagt ggctgtgagt gagctgagaa aaacactgtc tcagtctttg 372481 cctgactata tggtccctgc ccacctgatt caaatggaca gcctgccgct cacgccaaac 372541 gggaaaatca acaaaaagga actgcctgca ccgcaatcag aagccgtgca gccggaatac 372601 gcagcaccaa aaacagagag tgaaaagaaa ttagcggaga tctgggaagg aatactcggc 372661 gtcaaagcag gcgttaccga taacttcttt atgatcggcg gccattcttt gaaagcgatg 372721 atgatgacgg cgaaaattca agagcatttt cataaggaag ttccgataaa agtgcttttt 372781 gaaaagccga ctattcaaga actggcactg tatttggaag agaacgaaag caaggaggag 372841 cagacgtttg aaccgatcag gcaagcatct tatcagcagc attatcctgt atccccggcc 372901 cagcggagaa tgtatatcct caatcagctt ggacaagcaa acacaagcta caacgtcccc 372961 gctgtacttc tgctggaggg agaagtagat aaagaccggc ttgaaaacgc gattcagcaa 373021 ttaatcaacc ggcacgaaat cctccgtaca tcgtttgaca tgatcgacgg agaggttgtg 373081 caaaccgttc ataaaaacat atcgttccag ctggaggctg ccaagggacg ggaagaagac 373141 gcggaagaga taatcaaagc atttgttcag ccgtttgaat taaaccgcgc gccgctcgtc 373201 cgttcgaagc ttgtccagct ggaagaaaaa cgccacctgc tgctcattga tatgcatcat 373261 attattactg acggaagttc aacaggcatt ctaatcggtg atcttgccaa aatatatcaa 373321 ggcgcagatc tggaactgcc acaaattcac tataaagatt acgcagtttg gcacaaagaa 373381 caaactaatt atcaaaaaga tgaggaatac tggctcgatg tctttaaagg cgaactgcca 373441 atactggatc ttcccgcgga tttcgagcgg ccagctgaac ggagctttgc gggagagcgc 373501 gtgatgtttg ggcttgataa gcaaatcacg gctcaaatca aatcgctcat ggcagaaaca 373561 gatacgacaa tgtacatgtt tttgctggcg gcgttcaatg tactcctttc caagtacgcg 373621 tcacaggatg atatcattgt cggctcgccg acagctggca gaacacatcc tgatctgcaa 373681 ggtgtgccgg gtatgtttgt caacacggtg gcactcagaa cggcaccagc gggagataaa 373741 accttcgcgc aattccttga agaggtcaaa acagccagcc ttcaagcatt cgagcaccag 373801 agctatccgc ttgaggagct gattgaaaag cttccgctta caagggatac aagcagaagt 373861 ccgctgttca gcgtgatgtt caacatgcag aatatggaga ttccttcatt aagattagga 373921 gatttgaaga tttcctcgta ttccatgctt catcatgttg cgaaatttga tctttccttg 373981 gaagcggtcg agcgtgaaga ggatatcggc ctaagctttg actatgcgac tgccttgttt 374041 aaggacgaga cgatccgccg ctggagccgc cactttgtca atatcatcaa agcggccgcg 374101 gctaatccga acgttcggct gtctgatgta gatctgcttt catctgcaga aacggctgct 374161 ttgctagaag aaagacatat gactcaaatt accgaagcaa cctttgcagc actttttgaa 374221 aaacaggccc agcaaacacc tgaccattct gcggtgaagg ctggcggaaa tctgttgacc 374281 tatcgcgagc ttgatgaaca ggcgaaccag ctggcgcatc atcttcgtgc ccaaggggca 374341 ggaaatgaag acatcgtcgc gattgttatg gaccggtcag ctgaagtcat ggtatccatt 374401 ctcggtgtca tgaaggcggg ggcagctttc cttccgattg atcctgatac acctgaagaa 374461 cgaatccgtt attcattaga ggacagcgga gcaaaatttg cggtcgtgaa tgaaagaaac 374521 atgacggcta ttgggcaata tgaagggata attgtcagcc ttgatgacgg taaatggaga 374581 aatgaaagca aggagcgccc atcatccatt tccgggtctc gcaatcttgc atacgtcatt 374641 tatacgtccg gtacgaccgg aaagccaaag ggcgtgcaga ttgagcatcg taatctgaca 374701 aactatgtct cttggtttag tgaagaggcg ggcctgacgg aaaatgataa gactgtattg 374761 ctttcatctt acgcatttga ccttggctat acgagcatgt tccctgtact tctgggcggg 374821 ggcgagctcc atatcgtcca gaaggaaacc tatacggcgc cggatgaaat agcgcactat 374881 atcaaggagc atgggatcac ttatatcaag ctgacaccgt ctctgttcca tacaatagtg 374941 aacaccgcca gttttgcaaa agatgcgaac tttgaatcct tgcgcttgat cgtcttggga 375001 ggagaaaaaa tcatcccgac tgatgttatc gccttccgta agatgtatgg acataccgaa 375061 tttatcaatc actacggccc gacagaagca acgatcggcg ccatcgccgg gcgggttgat 375121 ctgtatgagc cggatgcatt tgcgaaacgc ccgacaatcg gacgcccgat tgcgaatgcc 375181 ggtgcgcttg tcttaaatga agcattgaag cttgtgccgc ctggagcgag cggacagctc 375241 tatatcacgg gacaggggct cgcgagaggg tatctcaaca ggcctcagct gacagccgag 375301 agatttgtag aaaatccata ttcgccggga agcctcatgt acaaaaccgg agatgtcgta 375361 cgaagacttt ctgacggtac gcttgcattt atcggccggg ctgatgatca ggtgaaaatc 375421 cgaggctacc gcattgagcc gaaagaaatt gaaacggtca tgctcagcct cagcggaatt 375481 caagaagcgg ttgtactagc ggtttccgag ggcggtcttc aagagctttg cgcgtattat 375541 acgtcggatc aagatattga aaaagcagag ctccggtacc agctttccct aacactgccg 375601 tctcatatga ttcctgcttt ctttgtgcag gttgacgcga ttccgctgac ggcaaacgga 375661 aaaaccgaca gaaacgctct gccgaagcct aacgcggcac aatccggagg caaggccttg 375721 gccgcaccgg agacagcgct tgaagaaagt ttatgccgca tttggcagaa aacgcttggc 375781 atagaagcca tcggcattga tgacaatttt ttcgatttag gcggccattc attaaaaggg 375841 atgatgctga ttgccaacat tcaggcggaa ttggagaaaa gcgtaccgct taaagcactg 375901 ttcgagcagc cgacagttcg ccagctggcg gcttatatgg aggcgtctgc tgtttcaggc 375961 ggccatcaag tactcaaacc ggctgacaag caggatatgt atccattgtc atccgcacag 376021 aaacgaatgt acgtgctcaa tcagcttgac cgccagacga taagctacaa catgccatct 376081 gttcttctaa tggaaggaga gcttgatatt tcgcgcctgc gcgactcact caatcagctt 376141 gtgaaccgtc acgaatcatt gcggacgtca tttatggaag ctaatggtga gcctgttcag 376201 cgcatcattg agaaggcgga ggttgatctt catgtgtttg aagccaaaga agacgaagcg 376261 gaccaaaaga ttaaggaatt tatccggcca ttcgacttaa acgacgcacc gctcattcgc 376321 gcagctttgc ttcgaataga agcgaaaaaa catttgctgc ttttagatat gcatcatatc 376381 atcgcagacg gcgtctcaag aggcatcttt gtaaaagaat tggcgctgct ttacaaagga 376441 gagcagcttc cggagccgac gcttcattat aaagatttcg ccgtttggca aaatgaagct 376501 gagcaaaaag aacggatgaa ggagcatgag gcgtactgga tgtcagttct ttcaggcgag 376561 ctgccagagc ttgatctccc gctcgattat gcccgtccgc ctgtgcaaag ctttaaagga 376621 gatacgatcc gtttccgtac gggaagtgag acggcaaagg cggtagaaaa actgcttgcc 376681 gaaaccggaa cgaccttgca catggtgctc catgctgttt tccacgtctt tttaagcaaa 376741 atttccggac agcgggatat cgtcatcggc tccgttactg ccggccggac gaatgctgat 376801 gttcaggaca tgccgggaat gttcgtcaat acacttgccc tgagaatgga agcgaaagaa 376861 cagcaaacat ttgcggagct tttggagcta gcaaagcaga cgaacctgtc agcccttgag 376921 catcaggagt atccgtttga agatctggtt aatcagcttg atctccctcg ggatatgagc 376981 cgaaacccat tgtttaatgt gatggtgacg acagaaaacc ctgataaaga acagcttaca 377041 ttgcaaaatc tgagcatttc accttatgag gctcatcagg gaacttctaa gtttgatctg 377101 acactgggcg gatttactga tgaaaatggc attggcttgc agctcgaata tgcgacagat 377161 ctgttcgcaa aagaaacagc tgaaaaatgg agcgaatacg ttctgcggct actaaaggct 377221 gttgcggata acccgaacca gccgctttcc agtctgttac tggtcaccga gacagaaaag 377281 caagcgcttc ttgaggcatg gaagggcaaa gcgctgcctg tgccgacaga caaaacggtt 377341 catcagctat tcgaagagac tgtccagcgc cacaaagacc gcccggctgt cacatacaac 377401 ggccaatctt ggacgtacgg cgagctgaac gcgaaggcaa accgcctcgc ccggattctg 377461 atggactgcg gcatcagccc ggatgaccgc gtcggcgttc tcacgaagcc gtcgcttgaa 377521 atgtccgccg cggtgctcgg cgtcttgaaa gccggagcgg cgtttgtgcc gattgatcct 377581 gactacccgg atcagcggat tgagtatatt ttacaggaca gcggcgcgaa gcttctcttg 377641 aaacaggaag gcatttcagt gccggacagc tatacgggag atgtcattct tctcgacgga 377701 agccgcacga ttctaagcct gccgcttgat gaaaacgacg agggaaatcc agaaaccgct 377761 gtaaccgcgg agaacttggc gtacatgatt tacacgtctg gaacgaccgg acagccgaag 377821 ggtgtcatgg tcgagcacca tgcgcttgtg aacctgtgct tctggcacca cgacgcgttc 377881 agcatgacag cggaggaccg cagtgcgaag tacgcgggct tcgggttcga cgcttccatt 377941 tgggagatgt tcccgacctg gacgatcggc gctgaacttc acgtcattga tgaagcgatc 378001 cgcctcgata tcgtccgcct gaacgattat tttgaaacga acggcgtaac gatcacgttc 378061 ctgccgacac agcttgcgga acagttcatg gagcttgaga acacatcact tcgcgtcctc 378121 ttgaccggag gagacaagct gaagcgggca gtgaaaaagc cgtacacact cgtcaacaac 378181 tacgggccga cagaaaatac ggtcgttgcc acaagcgcag aaatccatcc ggaggaaggc 378241 tcgctttcca tcggacgggc cattgccaat acgagagtat acattctcgg cgagggcaat 378301 caggtgcagc cggaaggcgt agccggagag ctttgcgtgg cggggcgcgg actggcacga 378361 ggctatctga atcgagaaga cgaaaccgcg aagcggtttg tcgctgatcc gtttgtgccg 378421 ggtgaacgca tgtaccgcac cggcgacttg gtgaagtggg tgaacggcgg catcgaatac 378481 atcggccgga tcgaccagca ggtcaaggtc cgcggctacc ggatcgagct ctcagaaatt 378541 gaagtccagc tcgcccagct ttctgaggtg caggatgcgg cggtgacagc tgtcaaagat 378601 aaaggcggca atacagcgat cgcggcgtat gtcacaccgg aaacagctga catagaagca 378661 ctaaaatcaa cactaaagga aaccctgccg gattacatga tcccggcgtt ctgggtgacg 378721 ctgaacgagc ttccggttac ggcaaacggc aaagtcgacc gcaaagcctt gcctgagccg 378781 gacatcgaag cgggaagcgg agaatacaaa gcgccgacga ccgacatgga agagctgctt 378841 gccggcatct ggcaggacgt gcttggaatg tctgaagtcg gtgtcaccga caatttcttc 378901 tcgcttggcg gagattccat caaaggaatt caaatggcga gccgcttgaa tcagcacggc 378961 tggaagctgg aaatgaaaga tctcttccag catccgacga tcgaagagct cacccagtac 379021 gtagagcgtg ccgaaggcaa acaggcagac caaggcccgg tggagggcga agtcatcctg 379081 acgccgatcc agcgctggtt ctttgaaaag aacttcacga acaagcacca ctggaaccaa 379141 tcggtgatgc ttcacgccaa aaagggcttt gatcctgaac gggtggagaa aacattgcag 379201 gcgctgatcg agcatcatga cgcgctccgc atggtctacc gcgaggaaaa cggggacatc 379261 gttcaggtgt ataaaccgat cggtgagagc aaggtcagct tcgaaatcgt ggatctgtac 379321 ggctccgatg aagagatgct gagaagccag attaagcttc tcgcgaacaa gctgcaaagc 379381 agtctcgatc tgcgaaacgg gccgctttta aaggcggagc aatatcgcac agaagctggg 379441 gatcacctgc tcattgctgt acaccatctc gtggtcgacg gtgtgtcatg gcggattttg 379501 cttgaagact ttgcttcagg ctacatgcag gctgagaaag aagagagcct tgtcttcccg 379561 caaaaaacaa actccttcaa ggattgggcg gaagaactgg cggcattcag ccaatcagcg 379621 catcttttac agcaggctga atactggtcg caaattgccg ctgaacaggt ttctccttta 379681 cctaaggatt gtgaaacaga gcagcggatc gtcaaggata catcatctgt cctatgtgaa 379741 ttaacggcag aagacactaa gcatctttta acagatgttc atcagccata tggaactgaa 379801 atcaacgata ttcttctcag cgcgctcggt ttgacaatga aagaatggac aaagggggcc 379861 aaaattggca ttaaccttga gggacacggc cgggaggaca ttatcccgaa tgtgaatatc 379921 tccagaacgg tcggctggtt tacggcacaa taccctgttg tgctcgacat atctgacgca 379981 gatgcctcag ctgtgatcaa aacagtcaaa gaaaacctgc gccgcattcc ggacaaaggt 380041 gttggctacg gcattcttcg ttatttcaca gaaacagcgg aaacaaaggg cttcacaccg 380101 gagatcagct tcaactattt gggccaattc gacagtgaag tcaaaaccga tttctttgaa 380161 ccgtccgctt tcgatatggg gcgccaagta agcggagaat cagaggcgct gtacgcatta 380221 agcttcagcg gcatgatcag aaacggccgg tttgtgcttt cctgctccta caatgagaag 380281 gagtttgaaa gagctacagt cgaggagcaa atggaacggt ttaaagaaaa cctcctgatg 380341 ctaatccgcc attgcacgga aaaagaagac aaggaattca caccaagcga cttcagcgcc 380401 gaagaccttg aaatggacga gatgggagat atctttgaca tgcttgagga gaatttaaaa 380461 taaaacgcaa gggaattaca gaaggcggga gcgaaacata tgagtcaatt tagcaaggat 380521 caggttcaag atatgtatta cctatcgccg atgcaggaag ggatgctttt tcatgccatc 380581 ctgaatcccg gccaaagctt ttaccttgaa caaatcacga tgaaagtaaa aggcagcttg 380641 aatatcaaat gtcttgaaga aagcatgaat gtgatcatgg accggtacga tgtatttcgt 380701 accgtgttca ttcacgaaaa agtaaaaagg cctgtccaag tcgtattgaa aaaacggcag 380761 ttccatatag aagaaatcga tctgacacac ttaacgggca gcgagcaaac agccaaaatc 380821 aatgagtaca aagaacagga taagatcagg ggttttgatt tgacgcggga tattccgatg 380881 cgggcagcca ttttcaagaa agctgaagaa agctttgaat gggtgtggag ctaccaccac 380941 attattttgg acggatggtg cttcggcatc gtcgtacagg atctatttaa ggtatacaat 381001 gctctgcgcg aacaaaagcc gtacagcctg ccgcccgtca aaccgtataa agactacatc 381061 aagtggcttg aaaagcagga taaacaagca tcactgcgtt actggcgcga atatttagag 381121 ggctttgaag gacaaacgac gtttgcggag caaagaaaga aacaaaagga cggctatgag 381181 ccgaaagagc tgctcttttc actgtcggag gcggaaacaa aggcctttac cgagcttgca 381241 aaatcgcagc ataccacttt gagtacggcg ctgcaggcag tctggagcgt attgatcagc 381301 cgctatcagc agtctggcga tttggccttc ggtacagttg tttcagggcg tcccgcggaa 381361 atcaaaggcg ttgaacatat ggtcgggctg tttatcaacg ttgtcccgag acgtgtgaag 381421 ctgtctgagg gtatcacatt taacggcttg ctcaagcggc tgcaggagca atcgctgcag 381481 tccgagccgc atcaatatgt gccgctttat gacatccaaa gccaggccga tcagccgaaa 381541 ctgattgacc acatcattgt ttttgagaac tatccgcttc aggatgcgaa aaatgaagaa 381601 agcagtgaaa acggctttga tatggtggat gttcatgttt ttgagaagtc gaattatgat 381661 ctcaacctga tggcttcccc gggagatgag atgctgatta agcttgccta taatgagaat 381721 gtgtttgatg aggcgtttat cctgcgcttg aaatctcagc ttcttacagc aattcagcag 381781 ctcatccaga atcctgatca gcctgtcagc acgatcaacc tcgttgacga cagggagaga 381841 gaatttttgc taaccggctt aaacccgccg gctcaagctc atgaaacaaa gcctctgacg 381901 tattggttca aggaagcagt gaacgccaat ccggatgcac cggcgcttac gtattccggc 381961 cagaccctgt cttatcgcga attagatgag gaagcgaacc gcattgcacg ccggctgcaa 382021 aaacacggtg cgggcaaagg ctctgttgta gcgctgtaca cgaagcgctc acttgaactg 382081 gtgatcggca ttctcggtgt attaaaggcg ggagcagcct atctgccggt tgatccgaag 382141 ctgccagagg accgaatctc gtatatgctg gctgacagtg cggcagcctg tcttctgacg 382201 catcaggaga tgaaagaaca agcggctgag ctgccgtata caggcacaac gctcttcatt 382261 gatgatcaaa cacggtttga agaacaggca agcgatcctg caaccgcgat tgatcctaat 382321 gatccggcat atatcatgta cacgtccggc acaaccggaa agccaaaggg caatatcacc 382381 actcatgcca atattcaagg attggtcaag catgtagact acatggcatt ttctgatcag 382441 gatacgttct tgtctgtttc gaattacgcc tttgatgcat ttacctttga tttctatgct 382501 tctatgctga atgcggcacg gctcattatc gcagatgaac atacgctgct tgatacagaa 382561 cggctcacag atctgatcct gcaagagaat gtcaatgtca tgtttgcgac aaccgcacta 382621 tttaatcttc tcacagatgc gggagaggat tggatgaagg ggcttcgctg tatattattc 382681 ggcggagagc gcgcgtcagt gcctcatgtc agaaaagcgc tgcggatcat ggggccgggc 382741 aagctgatta actgctacgg gccgactgag ggaacagtgt ttgcgacagc tcacgtcgtg 382801 catgatctgc cggattccat ctcctcattg ccgatcggaa agccgatcag caatgccagt 382861 gtttatattc tgaatgagca aagccagctc cagccattcg gggcggtcgg tgaactgtgc 382921 atcagcggaa tgggcgtgtc aaaagggtat gtaaatcgtg ctgacctcac gaaggaaaag 382981 tttatcgaga acccgttcaa gccgggagaa acgctttacc gtacagggga tttagcgcgc 383041 tggctgccgg atggaacgat tgaatacgcc ggccgtattg acgaccaggt caaaatacgc 383101 ggacaccgga ttgagcttga agaaatcgaa aagcagctgc aggaataccc aggtgtgaaa 383161 gatgcggtcg ttgtggcgga ccgccatgag tctggcgatg catcaatcaa tgcctacctt 383221 gtgaaccgaa cgcagctttc agctgaagac gtgaaggcgc acctgaaaaa acagcttcct 383281 gcttacatgg tgccgcaaac ctttaccttc ttggatgagc ttcctttaac gacgaacggg 383341 aaagtcaata aacggctgct cccaaaacct gatcaggatc agctggcgga agaatggatt 383401 ggaccgcgga acgagatgga agaaacaatc gcacaaatat ggtctgaggt tctcggcaga 383461 aagcaaattg gcattcatga cgatttcttt gcgctcggag ggcattcctt gaaggccatg 383521 accgccgcgt cccgcatcaa gaaagagctc gggattgatc ttccagtgaa gcttttgttt 383581 gaagcgccga cgatcgccgg catttcagcg tatttgaaaa acgggggctc tgatggcttg 383641 caggatgtaa cgataatgaa tcaggatcag gagcagatca ttttcgcatt tccgccggtt 383701 ctgggctatg gccttatgta ccaaaatctg tccagccgct tgccgtcata caagctatgc 383761 gcctttgatt ttattgagga ggaagaccgg cttgaccgct atgcggattt gatccagaag 383821 ctgcagccgg aagggccttt aacattgttt ggatattcag cgggatgcag cctggcgttt 383881 gaagctgcga aaaagcttga ggaacaaggc cgtattgttc agcggatcat catggtggat 383941 tcctataaaa aacaaggtgt cagtgatctg gacggacgca cggttgaaag tgatgtcgaa 384001 gcgttgatga atgtcaatcg ggacaatgaa gcgctcaaca gcgaagccgt caaacacggc 384061 ctcaagcaaa aaacacatgc cttttactca tactacgtca acctgatcag cacaggccag 384121 gtgaaagcag atattgatct gttgacttcc ggcgctgatt ttgacatgcc ggaatggctt 384181 gcatcatggg aagaagctac aacaggtgtt taccgtgtga aaagaggctt cggaacacac 384241 gcagaaatgc tgcagggcga aacgctagat aggaatgcgg agattttgct cgaatttctt 384301 aatacacaaa ccgtaacggt ttcataaatg aagtgatgaa aggaggagac agccaatgag 384361 ccaactcttc aaatcatttg atgcgtcgga aaaaacacag ctcatctgtt ttccgtttgc 384421 cggcggctat tcggcgtcgt ttcgccctct ccatgctttt ttgcaggggg agtgcgagat 384481 gctcgctgcc gagccgccgg gacacggcac gaatcaaacg tcagccattg aggatctcga 384541 agagctgacg gatttgtaca agcaagaact gaaccttcgc cctgatcggc cgtttgtgct 384601 gttcggacac agtatgggcg gaatgatcac cttcaggctg gcgcaaaagc ttgagcgtga 384661 aggcatcttt ccgcaggcgg ttatcatttc tgcaatccag ccgcctcata ttcagcggaa 384721 gaaagtgtcc cacctgcctg atgatcagtt tctcgatcat attatccaat taggcggaat 384781 gcccgcagag cttgttgaaa ataaggaggt catgtccttt ttcctgcctt ctttccgatc 384841 agattaccgg gctcttgaac aatttgagct ttacgatctg gcccagatcc agtcgcctgt 384901 tcatgtcttt aacgggcttg atgataaaaa atgcatacga gatgcggaag ggtggaagaa 384961 gtgggcaaaa gacatcacat tccatcaatt tgacggcggg cacatgttcc tgctgtcaca 385021 aacggaagaa gtcgcagaac ggatttttgc gatcttgaat cagcatccga tcattcaacc 385081 gtgatcaaaa gcggacagct tcggctgttc cgcttttttt gtgttgaatg ccaatttctg 385141 catggtataa tagtcgaaat actcaaataa aggcaggtcg aaacatgcgc acgtctccca 385201 ggatgaaatg gtttgtattg ctgtttacgt ttgttttcgc catcggaatg aactcattca 385261 gaaattcctt tcaatttttt atgctgccaa tggcagacgc cttccatgcc gacaggtcgc 385321 tgatttcggt ttctgtcagc atttttatga tcacaaccgg catcgtccag ttttttgtcg 385381 gtttttttat cgaccgtttc agtgtcagaa aaattatggc gctgggagct gtttgcatca 385441 gcgcaagctt tttggtgctt ccttattcac cgaatgttca tgtgttttcc gccatttacg 385501 gtgtgcttgg cggaatcggg tattcctgcg cggtcggcgt gacgacccag tatttcatca 385561 gctgttggtt tgacacacac aaaggtctgg cgcttgctat tttgaccaat gccaactctg 385621 cgggcctgct gcttctctcg cccatttggg ctgcggctcc gtatcatgcc ggctggcaga 385681 gcacctatac cattttggga atcgtcatgg cggctgttct gctgccgctc ctcgtctttg 385741 ggatgaagca cccgccacat gcgcaagcgg aaactgtgaa aaaatcttat gattggcgag 385801 ggttttggaa cgtgatgaag caatcccgcc tcattcatat cctgtacttc ggcgtgttta 385861 cttgcggatt tacaatggga attattgatg ctcacctcgt cccgatactg aaggatgcgc 385921 atgtctctca tgtcaacgga atgatggccg cgttcggggc atttatcatc attggcggat 385981 tattggcggg ctggctgtca gatctcctcg gcagcagaag cgtcatgcta tccatcttat 386041 ttttcattcg gctgctcagc ctcatttgcc tgctcattcc cattctcgga attcatcaca 386101 gcgacctttg gtacttcggg tttatcctgt tattcgggct cagttacaca ggcgtgatcc 386161 cgctgaccgc ggcgtcaatt tcggaaagct atcaaacagg attgatcgga tcgctgttag 386221 gcatcaattt ctttatccat caggttgccg gagctctcag cgtgtatgcg ggcggtttgt 386281 tttttgacat gactcatggt tatttactga ttgtcgctgt gtgcatcgtg tttgtgggtt 386341 tatcggctgt aatagagctg gtgccgtttt tagataaaca gaaggcaaaa gaaacccacc 386401 attcaatata aaaggatcag cactgtcaat gctgatcctt tttaaatttg agtttttttg 386461 tttcggtatt tttaaggata atctccttga atctgttcat ctcctcttcg gagtgaaaaa 386521 aatgtttggg gatcgcaata tattggccac ttgatgtatt gaccctgaag atatttttat 386581 attcgaaaac agctgtaatt tcatcccaat tgaaaatgag gtcatatttt ttagaacata 386641 tacgaattcc ttcttggttc agagtatatg ttcttttgga tttcatccgt tcgttcttct 386701 tgtatgctct ggaaaacttc acatatagaa gaaggaggag cagcagtgta aacagaacgg 386761 acatcacgat aatcaacata ctgttcataa acaagttaag cgcgtcactt ccataaacga 386821 tacggggcca tccgttaatg aagttaactg cagcaaatat ggcgcaaaac aatagaaagt 386881 aaaagcatga tatttttgcg atttgataaa aaaagatttc tcttacatcc ttaaaagtga 386941 tttctcctgg aagattgata ctttcactag catattgaat catacggtaa acctacacct 387001 ctaaccatgt ttttcctttt agtctagcat aatttctcat ttttttgcag gcataccagg 387061 gcgctttgtt tttttctcca gattgatatt gctccccacc acgccaatca taatacaaac 387121 agccccggca agatgatacc aggccaggct ttcgttgaga atcacaaatc ctgcaatcat 387181 cgtcacaatg gtagatacat gattaaaagc gctcatttta aacgcctcaa ttcgcgacag 387241 cgtatagtta gacagaaatg aagtgacaag tgaagacagc acgcccaaat acacaatggc 387301 gagaacgaag ccgggctccc ggaacggcag aaaataagtg ccgactgttc ccgccgctcc 387361 gtgacgcaca agggcgatgg cgttgaagac gacaaagccg atggctgaca tgatgtaggt 387421 gagctcggtc agcttgaacc gctgcgtcat ttttctggca gcagtattgt acatcgctga 387481 agacaaagcg gacaatagga tcagcaaaga cccttttaag ctggctgatt ccacgtcaac 387541 gcctttcatc acaaaaataa acatgacgcc ggcaacggat aaaaccgtga accccttttg 387601 cgtccacgtt gggcgttcct ttaaaacata agcggcaaag accatcgtga aaatcggaat 387661 ggctgcctga ataattcccg cttcagagga ggacgagtac acaaggccga atgcctgaaa 387721 gctgaaaaat aacgcgggat acagcagggc gagcggcaaa atgtcaatga cgtcctttac 387781 gcggattgat agctttaccc agccgaataa gatcggtaca gtggccgcag caaacgcaat 387841 ggtgaaccga tgcgccaaaa tatcaaacgg ctctgctgtt tgcagtgcga tttttacgaa 387901 tagaaaggat aaaccgataa tgaacgaata taaaatagcc gctatataag cgggggtttg 387961 ctgatgttta accataatgg gaagggctcc tttacctgaa ttgcagcgcc ggtcgctccc 388021 tttattgtat ggccgcggtc agaacggtac aatgagaaaa acaatgaact gtaccggtac 388081 aaaacagggg gagaaggcat ggagaaatat atgagtctat taacgaggat agaggagatg 388141 atgcaaagca cctcatatca agaaggagac aggcttccat ctatccgtca gctgtccgcc 388201 cgctaccaag tcagcaaaag cacagtgatc cgcgcgctgc aggagctgga aaagcgccac 388261 cttatctatt ctgttccgaa aagcggctat tatattgtga aaaagtcagg gaaatcaaaa 388321 agcgggcagc ctggccccat cgactttgcc acatctgcgc cggatcccga tgtgtttccg 388381 tatcttgatt ttcagcactg catcaacaaa gcgattgata catacaaaaa cgatttgttt 388441 atttatggga cgccaaaggg gcttccatca ctcatccgcg tactccgaaa gctcttggcc 388501 actcaacagg tatttgcgga tgaacggcat attttcatta catcaggtgt ccagcaggcg 388561 ttatccttgc tttgtgccat gccgttccca aatgggaaag agaagatcgc cattgaacag 388621 ccgggctacc atttgatggt cgaacagctt gagacacttg ggattcccgc catcggggtg 388681 aaacgaacgg aagaagggct tgatatagcc aaggttgagc ggttatttca aacagaatcg 388741 attaaatttt tttatacgat gccgcgcttc cataacccgc ttgggtgctc attgtcagag 388801 cgtgataaac aggagcttgt gagactggca gaagcgtatg atgtctatct cgttgaggat 388861 gattacctcg gtgatctgga ggaaaataaa aaggcagatc cgctgtacgc atatgatctg 388921 tcctcacatg tcatctattt gaaaagcttc tcgaaaatga tgttccccgg cctccgcgtg 388981 ggggcggctg ttttgcccga agcgctgact gacacgttct atgcgtacaa aaagctgaac 389041 gacatcgact gttcgatgat ttctcaagcg gcattggaga tttacctgaa aagcggtatg 389101 tacggcaggc ataaggagaa aatcagagat tcttataaag agcggtcgct gaggctacat 389161 caagccattc gaactcacag gcagctggga agcggacgct ttacgttctc cagcgggcag 389221 gcaccctgta tgcacaccca tctggtgctt cctcaggatc tgcccgcctc aagagtgatt 389281 catagactgg aaaaacaagg ggttctcctt gaggcgatag accgtcatta tttatcagat 389341 tatccgaaag aaaatctatt aaaaatcaat atttccaatg tgaaaacgga agatattgag 389401 cgcggtgtca agctgttgat gagccattta taaaagctct tcgtacgaga ccattgtgat 389461 atcctcgggg aaatcagggt gtacggcgca tacagccatt ttgtagccgg gatcgacctc 389521 atacgttttg atatagcatg gggaatggct gtccggaagc tcaatggata cttgtccgtc 389581 ctggtgcagg cgcactgaaa aggaatcaag cggaagcgat aagcctttgc cttccttgtt 389641 tgataaagct ttctttcatt gaccatagat gataaaaata gtctgtctgc tcgtccttgt 389701 cttttgctaa aaggtcgctg tactctgttt ttgaaaagaa gcgcttggcg atctcaaggc 389761 tgatcggttt cgttttttcg atatctatgc cgatcggctg tgaatcaaac gcgcaaatga 389821 cccagcgtcc ggagtgagaa atgttgaaat gagcgtcggg aagatcaggg atgcacggct 389881 tcccgtattc ctgcgtgcta aagcggatat cggatttgtc caactgatac tgcctgctta 389941 tgactgagcg aacgagcaca tctcccagca gggtgcggtg agcatcttct ttatgataaa 390001 atctccggca tttctcccgt ttttcaggtg atatgaaaga catgaaccgt tcattttctt 390061 cctgtgaaag cgggcggtcc atataaattc cgtaaatctt cattctagat cctccgtctg 390121 caaaagattg tcaaaaccat cctatcatac ttccacaaga ctcatataga ggagaaaata 390181 aaaaaacaaa gccaaggcgg ctttgtttta gtgtacaggc ggagatgctt tcactgcggc 390241 tgtccgcctt gccacagcat aattcagcaa ctggattgac tggggcaatg aaaaacgcaa 390301 aataagtccg gtgaggatgg cggtcaaaat ggtgccaaaa ccgatcggtc cgcccatgcc 390361 ccatgccgca aacaaaatgg ttaattccat gccgttccgc acccattgca cattccagcc 390421 ggttttttct gtaatcagca tcatcagtga atcacgcggc cccgcgccaa ggcctgctga 390481 tacataaaca ccgacgccgt aaccaatcag caccacgcct agagagaaga cgatgatcga 390541 gcctgtgtag gtcgagaggg caggcagaat gaaattgaaa aaatctataa atacaccaat 390601 gagcaccata ttcaggaggg caccaatttt cggccaagct ctcgtaaaca atgacgtgaa 390661 tccgacgatg agcgctccaa taatgatgga ccactggccg acggtaagcc cgaagtgctg 390721 aaacaggctg taatgaaatg catcccacgg actaatgccg agtgcttttc cttctatcgt 390781 cagggataca ccaaaagcca aaatgatcaa accggcaaaa taaaatgtcc agcgcagaac 390841 aagttcttgc ttcacgtgag gtcccttctt tcgtaaaaat cagtcgattg tcattgtagc 390901 acatctgaca gaagggcgga ataggcgaaa ggggctcaac aaaaaaacag ggccgccgga 390961 ggcgccctgt ttcagcgtgt tggcaaaccc ttgcattcgt tgtcaggcct gtgcttcggt 391021 gctcacgaat ttaacattag ctgtgctcca atgctcgccc ttcctagact tcaaaggttt 391081 tcaatcacgc tgaaaatcac aaaatcctaa aacgaatatc gttttaggat tttgtcaata 391141 atctgaaaca gggcgctgac gctctgtttt tcttattaca gcgggttcaa aatccggttt 391201 aagaaccgct gtgtccgttc ttcttttggt gcggagaaaa tttgctccgg cggtccctgc 391261 tccacgataa cgccgccgtc gatgaagatg acttcatccg caacctcctg cgcgaacttg 391321 atttcgtggg tcacgacgac catggtccag ccttcattgg ccaagtcctt gataaccttc 391381 agcacctctc cgacaagctc gggatcaagc gctgaggtcg gttcgtcaaa cagcatgagc 391441 tcaggctgta tcgccagtgc gcgggcgatg ccgacgcgct gctgctggcc gccggaaagc 391501 tggaacggat ataaatccat tttgtccttc aatccgactt tatcaagaag ctgaatcgct 391561 tcttttctga cttcctcttt gttccgtttt tgcacctgaa cagggccctc catcacgttt 391621 tcgagggctg tgcggtgcgg gaacaggtga tacgcctgaa acaccattcc ggattttcgg 391681 cgaagcttta ggatatccgc ctgtttcacc tttttggaga aatcgatgga gaaatcatca 391741 aatgcaagct ctccgcgatt cgggatctcc agagcgttca ggcagcggag cagcgtcgtt 391801 ttccctgaac ctgaaggccc aagtatggcg atgacttttc ctttttcaat cttcatatct 391861 atctttttta aaatttcatt ttcaccgaat gatttgttta atcctttaac ggtaagcata 391921 ctcggaacct ccttatttgg ccacgtagcg gtcaagacgc cgttcgatga catgctggac 391981 gagtgagagc aggaagcaga taatccaata aataaaggct gcttcaatat agatcactaa 392041 aatttgatca agattccgcg cgccgatttc ctgggctttt ctgaacagct cagcgaccag 392101 aatttgagag gcgagggatg tatctttaat caggctgata aaggtattgg ataatggcgg 392161 gatcgacaca cgaaacgcct gcggcaaaat gacgcggaac agcgtttttt gatgtgtcat 392221 gccaattgtg tagccggctt cccattgccc tttcggcacg gataaaatag atgcccgaat 392281 gatttcagat gcataggcgc cgacgtttaa tgaaaaggcg ataactgcgc ttggaaatgg 392341 atctaatgtg acgttaaagg ccgggaacag atagaaaatg atgaacaatt gaacgagaag 392401 aggagtgccg cgtattgcgg atacgtatac gctgaacacc catctcaaag gtctcacttt 392461 cgacattctg gcaagcgccg taatcagcgc caggatcatt ccgaatataa aggaaagaat 392521 cgtaagggga atcgtatagt agattccccc tgaaagtatc ggccagaatg actgctgcac 392581 cagatcccac gggatcgccg tgccaagcgt caatgccggc agattattta gaaacatctt 392641 cgccgaacca ttttttagaa attttagaaa gagtcccgtc ctctttcatt tcttttaatg 392701 ctttgttgac ttgatcaaca acctcgccgc ttcctttacg gaacgtgaaa tatgttgact 392761 gaggctcacc tgtttcaaac gcgattttca cgtttttatt gccagatgtt tttaagtagt 392821 tcaatacggc aagcttatcg ttgtatgtca tatcgacgcg gccttgctgg atcatttgaa 392881 gggcctgcgc catgccttca acgccttcta ctttagcgcc ggcatttgta gctaatttgt 392941 tgtagttgct tgtcagtgat tgagctgacg tttttccttt tacatctgct tcagacttaa 393001 tatcgttgtt gtcttttttc gttacgacaa cggctcttga tgttgtgtat ttatctgaga 393061 aatcatattt gtcttcacga tctgtttttc cgacttggtt ggcaacaacg tcaaaccgtt 393121 tggaattcag gccggcaaac atactgtccc attgtgtttc cttaaagtcg actttaagcc 393181 cgaggcgttt tgcgacttct gtgataactt cgacatcata gccagtcagt ttatcagtgt 393241 ctttgtcgtg gtaagtgaac ggctcatatg ttccttccgt tccgactgtg agcacacctt 393301 ttttcttaat tgaagcccaa agatcgccat ctttggcatt atcttttgac tgattgtcat 393361 ttcctgctcc gcaagctgca agagctgcaa tacttacgac catgaataaa gccaataatg 393421 cttttttcat cttattcccc acttttctgg ttgattttat tgaaataaaa aattagctta 393481 caaatctaaa ggataacttt tttttagtat gagtcaagta tttggttttc ataagacaaa 393541 atcttttaaa ataaatccaa aaattgctgt gccggtttag gcaaataact gtccgttctc 393601 cacatgacag ccggtgtcat aatgaaggga ttattttcga tatggacggt gtgaacgtga 393661 tttctcatat gaacgggaat cattgtgaca ggcaaaatag acgcgccgaa tccggatgac 393721 acgaggctga gcaaagttgc agagtcgtgg cattcacaaa caatgcgcgg ctccaggttc 393781 aaacgatgaa attcattcat gacctgatta tagacgcctt ttccgttgac aggccgcagc 393841 aggatcagcg gaaatgaagg aatgtccacc atcttaatgg tgtctccgca cggatatccg 393901 gcttcatctg aaagcacgag cacacatgga atgtcatcaa gctgcttgaa ttgtactgtg 393961 tcacttttga tcagtgttgt cgtgaccgcc gcatcgattt gccggctttc cagcagttcc 394021 aacagtgtcg cgggttcatt ttcccaaata ttaaaggtga gatgggggta tctctctttg 394081 atctgtgtta ctttttcaag catcagagcc gcgcaataaa tcgttgatcc cacggcaagt 394141 gtaccggcta cttcctcctt cagctcctgt acctcaatga ctgcatcttc aaacctatgc 394201 agaatctctt ttgctctttt tagaaaaaca gctccttcat atgtaagagt catttgtttt 394261 ttcttgttac ggtcaaacag aacaacacca agttcgtcct ccagctgttt gagctgcctg 394321 cttaaaggcg gctgcgccat gtgaagcttt ttggctgcgg acgtaatttt ctgttcttgg 394381 gcaatggtaa tgaagtatcg aagctggcga atatccaaaa gaaagcgcct ccttatcata 394441 ccttttaggt attaattata gatttaatag atatttttca tatggatata tcaggagtat 394501 gattgaaatg aaagcagaat tcaagcgtaa aggagggggc aaagtgaaac tcgttgtcgg 394561 aatgacaggg gcaacagggg ccattttcgg ggtcaggctg ctgcagtggc tgaaggccgc 394621 cggagtggaa acccatctcg ttgtgtctcc ttgggcaaac gtcacgatca aacacgaaac 394681 aggctatacg ttacaagaag tagaacaact ggccacatac acttactcac ataaggatca 394741 ggcggcagcc atttcaagcg ggtcgtttga taccgatgga atgattgttg cgccgtgcag 394801 catgaaatct ctcgcaagca ttcgcacagg aatggcggat aatctgctga cacgtgcggc 394861 ggatgtcatg ctcaaggaga gaaaaaaact cgtcctctta acgagagaga cgcctttgaa 394921 ccaaattcat ctcgaaaata tgctagcgct tacgaaaatg ggcaccatca ttcttcctcc 394981 gatgccggca ttttataatc ggccgagaag cttagaggaa atggttgacc atattgtttt 395041 tagaacgttg gaccaattcg gcattcggct tcctgaagcg aagcgctgga atgggattga 395101 aaaacaaaaa ggaggagctt gatcatggct tatcaagatt tcagagaatt tctcgctgcc 395161 cttgaaaaag aaggacagct gcttacagtg aatgaagagg taaagccgga accggattta 395221 ggggcctccg cacgggcagc cagcaatctt ggcgataaaa gccctgcgct cttatttaac 395281 aacatttacg gctatcataa cgcgcgaatt gcgatgaatg tcatcggctc ttggccaaac 395341 catgccatga tgctgggcat gccgaaagac acaccggtaa aagaacagtt ttttgaattc 395401 gcaaagcgtt atgaccagtt tccgatgccg gtcaaacgtg aggaaacagc gccatttcat 395461 gaaaatgaaa tcacagaaga tatcaatttg ttcgatatac tgcctctttt cagaattaac 395521 cagggtgatg gaggctacta tttagacaaa gcatgtgtca tttcccgtga tcttgaggac 395581 cctgacaact tcggcaaaca aaatgtcggc atttacagaa tgcaagtcaa aggaaaagac 395641 cgccttggca ttcagcctgt cccgcagcac gatattgcaa tccatctgcg ccaagctgaa 395701 gaacgcggca tcaaccttcc ggtcactatt gcgctcggct gtgagccggt cattacaacg 395761 gcggcatcga ctccgcttct ctatgatcaa tcagaatacg aaatggcagg tgcgattcaa 395821 ggcgaaccat atcgcatcgt caaatcaaag ctgtctgatc ttgatgttcc gtggggcgct 395881 gaagtggtgc ttgaaggtga gattattgcc ggagagcgcg aatatgaagg gccgttcggt 395941 gaattcacag gccattattc cggcggacgc agcatgccga ttatcaaaat taaacgcgtc 396001 tatcacagaa acaatccgat ctttgaacat ttatacttag gcatgccttg gacagaatgc 396061 gattacatga tcggcattaa cacatgcgtg ccgctttatc agcagttaaa agaagcgtat 396121 ccgaacgaaa ttgtggcagt gaacgccatg tacacacacg gtttaatcgc gattgtttcc 396181 acaaaaaccc gctatggcgg atttgcgaaa gcggtcggca tgcgcgcact cacaacgccg 396241 cacggactcg gctactgcaa aatggtcata gtcgttgatg aggatgtcga tccattcaac 396301 cttccgcagg tcatgtgggc gctttcgacc aaaatgcatc cgaaacatga tgcggtcatc 396361 attccggact tatctgtcct gccgcttgat ccgggatcca atccatcagg aatcactcac 396421 aaaatgattc tcgacgccac tacaccggtt gcgccggaaa caagaggcca ttattcacag 396481 ccgcttgatt ctccgctaac aacgaaagaa tgggaacaaa aactaatgga cttaatgaat 396541 aaataaggaa aggatgttcg aaatgcatac atgtcctcga tgcgactcaa aaaagggaga 396601 agtcatgagc aaatcgcctg tagaaggcgc atgggaagtt tatcagtgcc aaacatgctt 396661 ttttacatgg agatcctgtg aaccggaaag cattacaaat cccgaaaaat acaatccagc 396721 gtttaaaatt gatccaaagg aaacagaaac agcaattgaa gttccggcgg tgccggaacg 396781 aaaggcttga tccgcgtgaa ctgtatgtca gaccgtctct ttgagctgct tgacgggagc 396841 tgcctgaatg agaagcagca tgaggccttc gttctgcaaa cagtatcaga ggatggctgg 396901 ccgcatgccg ctatgatcag tgcaggtgaa atcatcgcgc tgagccgaac tgatatccga 396961 atcgctctgt ggaaaaacac aatgacttcg gccaacatcc ttcgcacagg aaaagcacag 397021 ttcacggcgt ggtggaaggg agcggcctat tatgtaaagc ttgaatgcgc gcctttaccg 397081 cctttgaaag atgccgaata tgaaagagac cgtttttcct gccgcatcgt ttcagtgaaa 397141 gaggacgttg cgaaatacgc tgatttgact tcaggtgtcc gtatacagct tcacagccct 397201 gaagaggtgc tgagcagatg gaaaaagacc ctggaagatt taaaacggta atatcgatag 397261 cctgacgcca tgcgtcaggc tttttttata taatgaaaac aaaagggggc gtgagaaatg 397321 gaacgtgcgg ggatctgtca ctcggacggc tttgatttag cttatcgaat tgagggcgag 397381 ggcgcaccca tccttgtgat cgggagtgcg gtttactatc cgcgcctttt ttcctcagat 397441 atcaaacaga aatatcaatg ggtctttgtc gaccataggg gatttgctaa gcctaagcgg 397501 gagcttcgtg cggaggattc gaggcttgat gctgtcttgg ctgatatcga aaggatgaga 397561 acatttcttc agcttgagga tgttactatc ctgggacatt ccgggcacgc ttttatggct 397621 ttagagtatg ccaggacata tcccaaacaa gttcggaagg tggcgctctt taatactgcg 397681 cctgataaca gtgaagaaag acagcgaaaa agcgaatcat ttttcatgga aacagccagt 397741 cttgagagaa agaaacgctt tgaaaaagac atcgagaatt tgccgcagga catcgacaaa 397801 gatcctgaaa ggcgctttgt gcacatgtgt attcgcgctg aagcgaaaag cttttatcaa 397861 gagcggccgc atgctgctgc cttatgggac ggtgtattca cgaatatgcc gatcattgat 397921 gaattatggg gcaatacatt tgcccggatt gatcttcttc agcggttagc tgatgttcgt 397981 atgccggtgt atatcggatt agggagatat gattatttgg ttgcgcccgt ttcgctatgg 398041 gatgctgttg acggtttata tccccatgtt gataaggtta tttttgaaaa gagcggccat 398101 cagccgatgc tggaagaacc ggaagccttt gatcaaagct tcaggaaatg gcttgatcaa 398161 taaaaaacag cccgcagatc aacatccgcg ggctgtttct gattataaga cccctttcat 398221 cgcgcgtttg atcaccggcg agagcagcag gagaatgccg ccaagaacga tagaaatcaa 398281 accgatggtg ccgaagtaca ttgtttcagg aattttatca aacaatccgg ctacttgggc 398341 attgatcgct tgggctgctg cgttcgtcag aaaccacata ctcattgtct gtgcagagaa 398401 ggcagctggt gccagtttcg ttgtcacgga taaaccgact ggagacaggc acagctctcc 398461 aagcacgaca agcaggaagc tgagaacgag ccaaagcggg cttacgagtg cttcttttcc 398521 ttgcatagca gggaatacca taatgataaa tgacaatccg gctaaaataa ttccgattga 398581 gaatttaact ggtgtagacg gctgacgttt gccaagcttc atccagagcc atgcgaatat 398641 tggcgcaaaa atgacaacaa acaatggatt taatgattgg aaccatgatg actgaagttc 398701 gaatccgccc aatgaaagtc ttatgcgttc atcagcgtat accgcaagaa tggtcgctcc 398761 ctgttcctga atggcccaga acatgacagc accgataaac aaaggaacgt aagcggcaag 398821 acgggatttt tctgttttgt ccgctttttt gcttgtaaac atgatgatga aataaatcac 398881 aggaatcaaa ataccgagaa tacttacaag gtcaatgaaa cgtttgatcg tcagcacgcc 398941 tgtttgtaca gagataatca ctgcgatcgc cacaatgata acaccgattc cggtgccaat 399001 tgcagatttt ttagacagcg gattcggcac attggaacct gcaagcccga ggtttttctt 399061 tcttgtcaaa gcaaatacga taagtccgag aagcattccg accgcggcag ctccgaatcc 399121 gagatgatag ttgtacttct gtccgagtgt tccgacaatt aacggcgcga gtaaaccacc 399181 gaggttaatc cccatgtaga aaatactgaa acctgagtcg cggcgcgggt cttctttcgt 399241 gtaaagatcc ccaactacgc ttgaaacgtt tggttttaat aagcctgttc cgacaatgat 399301 aagcaccata ctgatataga atgctatcga actgcccgga taggcgagtg caatgtggcc 399361 gaacataatg aatatgccgc cgtaaaacac ggtgtttgcg gtaccgaata cccggtcagc 399421 gagccatccg ccaataatgg tggacatgta tacgagtgat ccgtaaatcg acataatggc 399481 aaccgcagtg cccttgtcaa agccgagccc tccgtttacc gtctctgtat acaaatagta 399541 aagtaagatt gctctcattc catagtaaga gaaacgctcc caaaattcgg tgaaaaatag 399601 tgtaaatagt cctcgcgggt gaccaaagaa ccctttttgc gggacgcttt taatgatact 399661 ttcgttatca atcgaagcca tgtcagccaa accctttcta aaaaaagtgt attataaaaa 399721 tcatattctt atataatact tgtgtcaata taatttatac tcatttcaaa tagttccata 399781 ttggaaaaat tataaatacc taaaaatagt gatttcctcc taatttttaa actttttatc 399841 gtgagatttt cttacacaac tattccttta tattttttta ataaaatttt agagaaatgt 399901 acaagcagat cgggcctttg tgagtaacat gatagtaatc atagagaagg aggctcgcaa 399961 ttggctgaat tcatattaaa tgcagcggat ttcggtgttc ctagagatgg taaaacggat 400021 tcgacagaac ggattaatca gtgcctcagt acagctgttt cgaaaggcta tcatactgtc 400081 tggtttccaa agggaacata tttaatagac gcaacgcttg gcggagatct taatcagagg 400141 tttcgaaacg cggggatcat tgttcccggc aaccttgaga ttatgatgga ccccgaatgt 400201 atcatgaaag tgataccgaa tagttcgtgg ggttattccg cattttatgt aggcaagcaa 400261 gagaatataa ctatttccgg aggacaaatt atcggcgaac gggatgagca tacgtatgcc 400321 tcggcgggga taaggtcaac ccatgaatgg ggctttggca tatgtattga aggatgctcg 400381 aatgttgtca ttgatgatgt gaaaatttcc gattttaccg gcgatgggat catagtcagc 400441 ccaaggggat taaagaccaa tcaagattat cgaacgtcag agcaaattat catccgccgc 400501 tgtgaggttc ggcggtcgag gagaaataac atttccatta ccggatgtga catggtcacg 400561 gtggaggaat gcttgattga agatgccgga acggggaatg gaacagcgcc gaaattcgga 400621 attgacattg aaggatatgg cgaaggtgac gttgattatg aggaaccgat taatgtatca 400681 attcgcaata accactttgt tggaaacgtt tcaagttctg tgaccaattt taacgggtat 400741 ggcattttaa tagaaggaaa tcactcagac aatacaatca gctacggata tgggacgcaa 400801 acagtgatca agggcaatat tctgagacgc cctgaagacg cggcggctgc gccaagagtc 400861 gggataaccg gactcggtgt atcacaagga aaagagacca gtgatgcagt gatcgctggc 400921 aacctcatta ccggattttc aactggaatt gatgtcaggg gaaagagcgt tcttgtgacg 400981 aacaacaaaa tcagcaactt tgaaaacaca gggatattgg tttatcagtc ctccgacgta 401041 aaggtagacg gaaaccaaat tcaaaacgga ctgtctgaaa caaggcgcag catcggtctt 401101 cgcgcagtgc tgtcagatga catcgcattt ctgaataact gtctcattca agtcgttgac 401161 ggtgtgaacg tttccggcgg aaatatgatc attaaagata atctcctgag aaaattcagc 401221 cggggcattt ggattgctca agggaacgcg gtgattgaag ggaatacact gaatcctgac 401281 gcgtttgaag cagtgccgga atcatattct gtttccgtca caaacaatgc cggcgccatc 401341 atcaaaaaca atacatttaa agagttcaaa aattacccca tttattgctc cacaagtgca 401401 aaaacctcaa ttatcggcaa ccacttagag cgatccccgc ttttggtcac catctatatc 401461 agcgcaggtg tgcatgagat ttttgataat accatttcag tcaacagaac agccgggaat 401521 ccgattgtga tttatctcaa tggctctgca ggctctatca tctctggaaa caccatcaat 401581 aacctctccg cgggcactgc gacagctatt caaacaaaca cgtcaaccaa ttccaaaatc 401641 atcggcaacc gcatttttaa agggaccatc aacaaacaca gcagtgatac aatagacggc 401701 aatatgattg tctgaaaaaa gcgcccccct ttaggggttc ttttttttcg atttatagat 401761 cacgtacatt tctctcacaa gtactaacac aaaaaataaa agcacgaccc attccgcaaa 401821 tgttgtcatc ttaaagctgg acatattgtt ataaacggct tttgttaaac tgaacccttg 401881 aagcatgtcc atcaacacag aaatagctaa taaacaaatt aatatgaatc cggtcacgcc 401941 caatatcttc atgcttcatc atcctccgct tttagtgtct atctttggcg gagaagttat 402001 accgcatcta accctaatgc ataatctcaa ttttaaaagg aagaatatga gaaaacgaca 402061 aggaaaggta tttgtgtatg cctttatttt ctaagcgaaa gaacaatacc gattcaaaag 402121 acaagcagaa tacagacgaa aggaatcagg aacagcagca agaaaaagaa aggccggttc 402181 tcatttctcc aagtttagca aagaatatag cggaaacgaa aaaggaagtc ggaagcagct 402241 ctgacgtcat cattcgcgag attaaaatcg gggagcagga tcatgtccac ctagctgtta 402301 tctatatttc tgggctggtc gataataaca cgatccatga gtcgttaatt gacccattgg 402361 tacaggatga gtctatccag aatactcatg cgatccagca aattcttgaa aaaacgctcc 402421 cgctgggcgg ggtgaaagcg gaaaagagct gggacaagct tttttccgag ttaatgcttg 402481 gcaatgcgct catttttgct gatggccatg atgaagcttt gatttgcagc actcaagggg 402541 gagagcagcg ctccatccaa gagccgagca cccaggtgtc attccgcggc ccgcgccaag 402601 ggtttacaga gtctctgcaa accaatattt ccatgatccg gcgatacatt aaaaatccga 402661 atttatgggt tgaaaaaatg aaaaaaggtt ctgttacgaa tacggatatc gctctcatgt 402721 acattcaagg aatatgtgat gaaaaggtgc tgaaggaagt gaaacagcgc ctggaaaaaa 402781 tagatattga cagtattttg gaatctggat atattgagca gctgattgaa gatgaaacct 402841 ttacgacgtt tccgactatg tatcatacag aacgccctga tgttgtagcg ggtaatctgt 402901 tagaaggaag attcgcgatt attgtggacg gaacaccgtt tgtgcttatt gccccagcct 402961 tatttgtcca gttttttcag tctgttgagg attattattc gcgttttgac attgcgacaa 403021 gcataagaat tcttcgtgtt ttagtctttt tcatttcgct tgtggcacca gctgtatacg 403081 tggcagccac gacgtttcat caagaaatga taccgactca gctgttagtg gtcattgcgg 403141 cccagcggga aattgtcccg tttccggctg ttgtggaggc gctgacgatg gaggttgctt 403201 ttgagattct gagggaagcg ggagtcaggc tgccccgggt tgtcggctcg gcagtgtcaa 403261 tcgtaggcgc gctcgtaatc ggccaggctg ccgtacaggc tggtatcgtc tctccggcaa 403321 tggtgattat cgtggcactc accgcgattg cgagcttcgc aacaccggcg tttgcaatgg 403381 cgatttcagc ccggcttatt cggtttatct ttattattgc ctcagctgtt atgggttttt 403441 acgggctgat tttagggatc attatgatgt ttgtccactt atgcagtctt cgttcattcg 403501 gcgttccata tatgtcgccg cttgcacctt tttcttcaca aggcgtaaag gacgcgcttt 403561 tccgggttcc gtggtgggcc gatgaaaaaa ggccggaatc ggtcagcaag gaagataagg 403621 tgcggcaggg gaaagatcaa cgcccagagc cggccgcttc acgaggaatg gtgaacaaag 403681 atttggaaga aggggatcag aatggtacgt aaatgtctat tagccgttct catgcttttg 403741 agcgtcattg tgctgcccgg ctgctgggat aagcgggagc tgacggatct tgcgattatc 403801 tcggcgattg gcatcgatcg gacaaacgac agcaactacg tgctgcatct tcaaattatc 403861 aatccaggaa atgttgccgg cggccttcag ggaggcggtg ctggagacag gccgcctgta 403921 tctgtctatt cgattgaagg taacaatata acggaagcac tcagaaaagc ctccatgaag 403981 gtatcacggc ggctttattt tgcccatacc aatctagtcg tgatcaatga aaagctggca 404041 aaagaagaag gtttggattt tgtattagat aatcttgacc gggacacaga attcaggaca 404101 acagcaacat tcgtcgttgc ccataaaaca aaagcagaaa atattgtgaa aatcttgacg 404161 ccgattgata aaattccgtc aaataaagtc aataaaacac tcgatttcac ggaggcacaa 404221 tacgggcggg tggtcaaaat caatattcag gacgttttga aaacacttgc cgccaacact 404281 atggcaccgg tcatccccgg atatatgatg attggtgacg ataaaaaagg agtcagcatg 404341 gaaaacacgc aggcgactga cccgaaagcc attcttcagg cagatggttt ggcggttttt 404401 gataaggcag gatatttaaa gtattggctg gaagatgatg aaagcgtggg ggcagtctgg 404461 cttatgaata agatccagca tacgtttatt aatgctgact ggggcaagac gaaggatgcg 404521 gtcagcttgc aggttaccca tcaagataca aagctggtac cgaaaatgcg gaacggacgc 404581 ccgtacatcc atgtgaaagt gtcggttgaa ggtattatag atgctgtcaa ataccctttc 404641 caattgtctg atcccaaggt gctggccgct attgaaaaag cgctcaacaa agagcttgaa 404701 aaggaaatca gccatactgt gaaaaagatt aagaagaata aaatagattt tatcggtttt 404761 ggtgacacga tatatagaaa gtatccggag cagtgggaga aaatgaagga cacttgggac 404821 aaagaatatt tgccggaact gcccatcgat gtgaaggccg agacgtatat cagaaggacg 404881 ggattgcgaa acaatccgat caaacaccag tttaaagatg attaggtctg aagaaagggg 404941 aagtgacaga tggaaaaagc cagaataagc ataaggcagt tgtttgtcat gattatcatt 405001 tttgaactgg gcagctcctt attgattaca ccgggatcaa tggcgggcag ggatgcttgg 405061 atagcagttt tattaggctg tgcgatcgga ctgtttcttt tctatttgta tcaaggcatt 405121 tatcaatgtt atccgaattc ttctccgaaa gaatatatgg atgatatgct gggaaccaag 405181 ctgagctggc tgttttcatt tctctatatc ttgtactttg cctatattgc cgcaagggtg 405241 ctgcgtgact ttggagaaat gctgctgacg tttgcttatc atgatacacc tatcattatt 405301 gtaaatgctt tattaatggt agtaagcata tatgccgtaa gaaaaggaat tgaagtactc 405361 gcacgcgcgg ccgaacttct tttcggggcc atgtatttac tgggcgcgat cggccttgtg 405421 ctgattattg tctcagggac tatagacccg cacaatttaa agccggtttt ggcaaacggc 405481 atttctcctg tccttcactc tgttttcaca cagaccatgt acgttccatt tggtgaagtt 405541 gttttatttg tgatgatttt ccctaacctg aatgacagaa aagatgtgaa aaaaatgggg 405601 atgatcgcca tggctattag cggattgatt gtggcgctca ccgtggcgat taatattagc 405661 gtgcttgatg ttgatcttac actcagatcc cagtttccgc ttttaagcac gatccagaca 405721 atcaaggtcg aagaattttt agaccggctc gatgtctttt ttatgctggc gctgatcatc 405781 ggcggcttct ttaaggtcag cctctactta tatgccactg tggttgggac atctacgctc 405841 tttaaggaaa agaacccctc tcaattggct tatccgatgg gattgggcat cttaatcctt 405901 tctataacga tcgcgactaa cttttcggag cacttgaatg aaggcctgaa cgtggtgccg 405961 ctgtatattc atttgccttt tcaattattg tttccgctct ttctgtttat tgtggccgtt 406021 tggaaaaaga aacgaagaga gaagtcaaaa ggggaggaag caaaaaaatg ataaaaagag 406081 cggggggatg cggccgccgc tctttttatg ttcacttcta tataaaaggg ggatataggg 406141 tgcgcccctg tctgcactgg cagaggcgcg ttttgttata cgactgcgac gttttccttc 406201 acagtaaaac ttcctcttga aagtctgata ttgatgtctg acacttttgc aatttgttca 406261 tcgtgcgtca ccataatgac gcatttatct tccttgtgcg ccagatcctg aaagagccgt 406321 acgatctctt ttgatgtgtc ctcatcaagg tttccggtcg gttcatcggc tacgataaga 406381 tccgtgtcac agcagaaagc ccttgtaatt gatacccgct gctgctgtcc gccgctcagt 406441 gtgagcactt tttgccgggc ttgtttttcg ttgatgccaa ccttctgcag catgtcaagc 406501 gcatatgatt ctttgttctt ttctttagaa cctgtgattt ccatagcggt tgtgacgttc 406561 tgcaaagccg tcatatacgg gagcaggttg tacgcctgaa agacgattga tacatattga 406621 tttctgaaat tggttaagcc gattttagaa accgcttttc cgtcgtaaag gatgtttcct 406681 tcttttggtg cgtcaagtcc gcctgccaga gacaggaaag tggttttccc cgtccctgat 406741 gttccgacga ttgtgtagaa ttttcctttt tgaaagctga tgttaatatc ctgaaacaat 406801 ggctggcttt tgtttttata ccagtagccg acttgttgaa attgtaataa gctcataggt 406861 tccgcctctt tctattcctg ttttgtcaat atcgttttcg gatgaagccg cagtactgaa 406921 attgacggca gcaatgttgc aatgattgcg attaggatgc cgatcccgcc aagtataagc 406981 atgtcgttca tagaaaccgc gacgttcagt gaatcgataa cgtccacgtt ggatgaactg 407041 tggccgaaca ttttgccgcc catgccgcca ccgccgccgg gcatttgtcc gcttgcggtt 407101 tgcgttgaat cggttgatga actgatttgc tgggataaaa gctgatttcc aagctgattc 407161 gcgacgagat ttcccgtcac agatgcaagg ccgatagcga taacggccac aatcagaatc 407221 tcagtcaaga actgtccaat caatttccat cgtttttcac cgatggccat taacacgccc 407281 atttcgtatt tgcgctccct gattgacatc atgacaatca ggccaagaat gacggcgcct 407341 gccactgata caagatacac cacgttttta gagaaagaag ccacattttc aatcggtccg 407401 accatttgct ggtaaagctg atcgtttgta ttcagtgtgt acgtatcaaa gtcaattgat 407461 gttttcttcg ctgcttttac gaaagtatcc atatttttcg cgtcgtccat atagtaaaca 407521 gctgagtcaa tcgtattttt atagtcgtcg cctttcaatg ccgctgttgc tgtgtaaggc 407581 gtataaagct tgttataagg atttaagaaa gagaaatttt gggcttggtc atcacctgaa 407641 gatgttgttt tataaatacc gacgatcttc agttttactg ttgtatcctc atccgttgct 407701 gattcaattg tgatcgaatc gccaacgctt aaatcatttt cttccgctaa tgtttcgttg 407761 atcactgtta cttttttgcc gacatctgat tttgtaatcg cgcgtccgtc tgtgattttt 407821 gaatctccgt cagagaaatc atcgactaac gctgtgctga tgacaccttc aatagaaaga 407881 tcagcttgaa ccatttgcgg tccgccttgt cctccgcctt gactgttttt agcgtttgag 407941 cttgaactgc tggagctgga atcacttgaa ctagagcttt caatcgcatc aaagtttccc 408001 gcgttggctg aagctgatgt ggtgtaattg tagctcttca catgatcaag cgctgcaagc 408061 ttattcgcat cagacacttt gatcggtgtg gattcgaagc tgcgcttttc accgctgtcc 408121 tgctgttttt ccatttgctt ttggcggtca acctgaagtg tcacgcttcc accgagttcc 408181 tgtctggcca gttcgcttga cttttgtgct gccgactgga tggcgaggcc tgatagaaca 408241 aagacacata tgactgtaaa cacaaataat tgcaataacg tttttccctt tttagccttc 408301 atattccaaa aggcccgttt gataaagttc atttatgttc ctccgtatag gtatttttat 408361 tgataagacc gcctctgggg cgcgtcccct tgctgataaa ttaatagtag tccaaaggta 408421 tgaaaaaaat atgaacaatc tatttctagt tgatgaaata aaaactaaca attgtgaaac 408481 gcaaaacctt ctgtttaaaa tggtgctatt atataaaaaa gcatcaaaac aaccggagga 408541 tataatgaaa atattaatga tagaagataa tgttagtgta tgtacgatga cggagatgtt 408601 cttttttaaa gaaggttttg aagccgaatt cgttcatgac gggttagaag ggtaccagcg 408661 ttttacggaa gaaaattggg atctaatcat tttggatatc atgcttccat ctatggacgg 408721 cgtgaccatc tgcagaaaaa taagagagac aagcacggtg ccgattatca tgctgactgc 408781 caaagacact gaatcagatc aggtcatcgg ttttgagatg ggggcggacg attatgtcac 408841 aaagccgttc agcccgctga cattggttgc ccgcatcaaa gccgtcatca gaagatataa 408901 ggcgacaggc aaagcggtta ttgatgaaga tatgattgaa acggaatgct ttaccattaa 408961 taagaagacg agagaagtat tattaaacgg agagcctgta gaaaatctca cgccgaagga 409021 attcgatctg ctttattacc ttgtccaaaa tccgcggcag gtgttctcca gagaacagct 409081 gcttgagcag gtatggggct atcaatttta tggagatgag cgaacggttg acgttcatat 409141 caaacggctg cggaaaaagc ttgccagcga ggacaagcct ttcctgtata ctgtgtgggg 409201 agtagggtat aaatttgatg aagattaaat atttatatca gctgctgcta agccatatca 409261 gcattttgat tttagcgttt gtcattatca tttctctgtt ttcccacttt gtgaaggaat 409321 ttgcctatca gaacaaagta gaggaattga cgtcatatgc ggtgcagatt gcaaatgaat 409381 tccaatccgg ccaggtggac atgcgcaggc tctatcctta tcaggacatt ttaagcacaa 409441 gaaagacgca atttatcatc tttaatgaag agcagcagcc ttattttctt cctgaaggct 409501 ttcatcaccc accaagggaa cagctgaaga aatcagaatg gaataagctg aaaaaagggc 409561 agactgtcac gatcagggca gatggccgtt ttgatgatga agtgtccctt gtggcgcagc 409621 ctatatttgt tcagaacgaa tttaaaggcg ccgttctgct gatttctccg atcagcggtg 409681 ttgaacagat ggtcaatcag gtcaacctct atatgtttta cgctgtgatc agcacgcttg 409741 tgattacgat tcttgtgagc tggcttctgt ccaaattcca tgtcaagcgg attcaaaagc 409801 tgagagaagc gacagataaa gtggcttccg gcgattatga catccatttg gaaaacagct 409861 acggggacga aatcggcgta ctggcgtctg actttaatat catggcgaaa aaactaaagc 409921 agtcaaggga tgaaatcgag cgccttgaga agcggagaag gcagtttatc gctgacgtgt 409981 cacatgaatt aaaaacaccg ctgacgacga tcaacggttt ggttgaaggg ttgaacagcc 410041 atacgattcc tgaggataaa aaggataaat gcttctcgct gatcagtgag gaaacgaagc 410101 gcatgctgcg gctcgtaaaa gaaaatctgg attatgaaaa aatcagatcc cagcaaatta 410161 ccttgaacaa gctagacgtt cctctgatcg aggtgtttga aatcgtgaaa gagcacttgc 410221 agcagcaggc ggaagaaaaa caaaacaagc tgatgatcca agtagaggat cacgtcatcg 410281 tacatgccga ttatgaccgg ttcattcaaa ttctcgtcaa cattacgaaa aacagcatcc 410341 aatttacgca aaacggtgac atttggctgc gcggaatgga aggttataaa gagacgatta 410401 ttgaaattga agacacgggt atcggcattc caaaagagga tattgagcat atttgggagc 410461 gattctataa agcagatatt tcaagaacga acacagcata cggtgaatac ggactcggtc 410521 tctcgatcgt caggcagctc gttgaaatgc accagggcac agtagaaatc aagagtgaag 410581 aagggaaagg cacaaagttc atcatccgcc ttcctttaac ggcaaaacag caatagcata 410641 cagggcggcg catcaactga tgcatccgcc ttttttgcac accgcttcgg tttattgcgt 410701 gctcccgaaa acaaagattg cgtgtttttc gggttgggac ggcctataaa catgataaaa 410761 tatgacataa acagtttttg atgggagagg gtgaaggaat gaagagtggg gtaattcctt 410821 cttcagcggt cggtcaaaaa attaacgagt ggtacagata tatccggaca ttcagcgtgc 410881 cggatgccga agtgttaaaa gctgaaatcc agcaggaact gaaacacatg cagcatgatt 410941 ccaacttgct gctttattat tcactaatgg aattccggca ccagcttatg ctggattatc 411001 ttgagccgtt agagaaatta aatatcgaag accagccaag cctgtctgaa ttatcaagaa 411061 acattgacag caaccaggca gatctcaaag ggctgctcga ctattacgtg aatttttttc 411121 gcgggatgta tgaatttgat aagcgggaat ttatttctgc cattacatac tataaacagg 411181 cggagaaaaa gctctccttt gtcgcagacc atattgaacg ggctgaattc tattttaaaa 411241 tcgcggaagc ttattattat atgaagcaaa cgtatttttc attgattaat ataaaaaacg 411301 cctatgaaat ttacgtggag caggaaacct ataatgtgag aatcattcag tgccatttcg 411361 tcttcggggt caacctgatg gatgaaagaa atttcgaaca agccgcacgc catttcaaat 411421 tggcgctcaa catggcccaa gcagaacaaa aagcccagct ggttggaaga gcatactaca 411481 atctcgggtt atgctattac aatcaagacc ttctagaccc tgccattgat tactttgaaa 411541 aagcggtctc cacatttgaa agcagcagga tcgtcaattc tctcccgcaa gcctattttt 411601 taatcaccct gatttattat aaacagggaa aacatgataa agcttcggaa tatcacaagc 411661 ggggctatga atatgctaaa gaaacagacg atgcagacta tgccgtaaaa ttcgagtttt 411721 tgcaatccct atatctggat cagcccaatg aagaaggaat cgaacgatgt ttccagtact 411781 taaaaaataa aaatatgtac gctgatatag aggatttagc cctagaagta gcaaaatatt 411841 actatgaaca gaaatggttt aaactgtctg cttcctactt tctacaagtt gaagaggcaa 411901 gaaaacaaat acaaaggagt gaaggtttgt atgaaattga aatctaagtt gtttgttatt 411961 tgtttggccg cagccgcgat ttttacagcg gctggcgttt ctgctaatgc ggaagcactc 412021 gactttcatg tgacagaaag aggaatgacg taagaacaag ccccttctca ttagcgagaa 412081 ggggtttttc ttttcaaaaa aacaccgcaa gacatagtct tgcggtgccg ccttcatgga 412141 gattacgttt atttagtagc ctcctacaaa tgcagttccc acaatgatca agaggataaa 412201 taacacaaca atcaaagcga aagaagttcc gtaacctgac attttgtgca cctccttgcg 412261 agattgcttc agcaaatgct gcaaaactgt ggcggacagg gtcccgcaga gacggtcagc 412321 agcttagaag ccgccaacaa acgcagtccc tacgataatt aatagaataa acaatacaac 412381 gattaaagcg aaagaactga tgccgccgta accgccgccg ttagagtatc ctgacataag 412441 gtttcacctc cctatgaagg atactataag atatgctgaa ccgatccatt tggcagggat 412501 aatagtggac aagagaaaaa atgaagaatt cggctatatg aaggtgatat aaaaaaatag 412561 cgggcgctgc cgcccgctat ttatgtacga ttaagagatc agcacgcccg cgaaaaattc 412621 ctggtataac gcttgaacgg cttttctttc ttcggcttct tttacgccaa acatcatgct 412681 cacttcagaa gacccctgat tgatcatttc gatattcacc tgtgcctctg ataatgcttt 412741 ggcggctctt gccgttgtac cgacattgtg gcgcatcgct tcccctacaa ccataatcag 412801 ggcgagatga tgctcgacga tgacttcatc ggcatgcaaa tcctcttcga tccgtttgat 412861 gacgctgcgt tcagtggcgg catccatttg cccctgccgt aaaatgattg tcatgtcatc 412921 gattcccgat ggaacatgct catacgtcaa accatgctcc tccaggattt gaagggctct 412981 gcggccaaaa ccgatttctc tgttcatgag atacttgctg atataaatgc tgcaaaaacc 413041 ggtgtcgctg gcaatgccga cgacaggccc gtttgtgtta tcccgcttgc tgacgacgcg 413101 ggtgccttcg gctgaggggt tgttcgtatt tttgatctga acaggaatcc ccgctctgaa 413161 tgccggaatg agcgcttcat catgaaacac tgaaaaaccc gcgtaggaca gctcccgcat 413221 ctctctatat gtcagctcgc tgatttcctt tggattctca acgaaggacg gattgacaga 413281 atacacagcg tctacgtctg taaagttttc gtacaaatcg gcttgtagtc cgttggcaag 413341 aatcgaaccg gtaatatcag aaccgctccg tgagaatgtg atcacatcgc catccttgct 413401 gaatccgaaa aaaccgggaa aaatgatgag tccgtcacgt tcccgaagac gatagaggtt 413461 ttgataggat tcaggaagaa cttgcgcgtt gccgggttca tttgtcacaa agaggccggc 413521 atccttcggg tttacatatt ccgctttgac gcctttataa cggaagtaag cggcgatcag 413581 tttggcattg ttatcctctc cgctggcctt gactgcgtca aggtattgtt cgggattgct 413641 tttgtctcct tctaaaagcg taaacagatc atctctgatt ttttcgataa tgctttgccc 413701 cagctgaagc tcattggcga tgagagcgta ccgttccaca acagcttccg ccagttcagg 413761 tgcgctgcct gttgccaaat attgttctgc acatgcgatt aagagatcag tcactttcgt 413821 atcctcggca tagtgttttc ccggagctga aacgactaca gctttccgtg ccggatctga 413881 ggtaacgatg tgaaacacct tgtcaagctg ggcgcctgaa gcaagtgagc tgcctccgaa 413941 tttaacgacc ttcatgttta catctcctaa tgtttaaaat tttcacacaa atttagtatt 414001 tattatctct ctttcagtac tgtaaatcaa gggggaattt ctttctcagg agaacatttg 414061 tatttttcac gaggaataat gttaggtttg ctgaccgtat gcctgcgtta taaagataaa 414121 tatggtaaac agcctaacgt tttgggatgg aaaatggtta gaatgattag taaaattgat 414181 aaatgactag gttaatattt ttaaagaata ttgactaacc ctataaaaat ggtaatatgt 414241 aaatgataat gataatcaat tactatatgg ccatattgtt ttgagtcctt gcggagtagg 414301 agatacgttc tttttgctgt aaggatgtaa ggaggcagca tgaagctacg ttacttattt 414361 attctactta tcatattagc agtcacatct gtatttatcg gtgtagaaga tctgtcgccg 414421 cttgatctct tcgatttaag caaacaagag gcgtcaacgc tgtttgcaag ccgtttgccg 414481 cgattgatca gcattgtcat tgcgggatta agcatgagca tctgcggttt gattatgcag 414541 cagatcagca gaaataaatt cgtgtcaccg acgacggcgg gcacgatgga ttgggcgagg 414601 ctcggcattt taatttcctt gctgctgttt acatccgcca gtcctttaat caaaatgctg 414661 gtcgcgtttg tctttgccct tgcaggaaat tttctgttta tgaaaatcct tgaaagaatc 414721 aagtttaacg acaccatctt tattccgctt gtcggtttaa tgctcgggaa tatcgtcagt 414781 tcaatcgcga catttatcgc atataaatat gacttgatcc agaatgtgtc atcatggctg 414841 cagggagact tctctttagt cgtgaaagga agatacgagc ttctttatct gagtattccg 414901 ctcgtcatca ttgcctatgt gtatgcggat aaattcacat tggccggtat gggtgaaagc 414961 ttttctgtca acctcggcct caagtataaa cgggttgtga acatcgggct cattatcgtg 415021 tccctgatca cgtctcttgt cattttgact gtcggtatgc tgccgtttct cggtttaatc 415081 atcccgaata ttgtatcgat ttacagagga gacaatctga agagcagcct gccgcatact 415141 gtgctgttgg gagcggtttt tgtgctgttt tgcgatatac tgggcagaat cattatcttc 415201 ccttatgaaa tctcgattgg cctgatggtc ggaatcatcg gcagcggcat tttcctgttt 415261 atgctgttaa ggagaaaagc ctatgcgtaa ccagatgaaa atagctttgc tcgttggttt 415321 agccattgta tgtattggct tgtttttgtt ttatgactta ggcaattggg attacaccct 415381 gccgagacga atcaaaaaag tcgctgccat tgtgctgact gggggagcga ttgcgttttc 415441 gaccatgatc tttcaaacga ttacgaacaa ccgcatcctg acgccgagca ttttgggcct 415501 tgattctctc tacatgctga ttcagactgg cattatcttt ttgttcggtt ctgcgaatat 415561 ggtcatcatg aataaaaaca tcaactttat catctctgtt ctgctgatga tcctgttttc 415621 tcttgttttg tatcagatca tgttcaaggg tgaggggaga aatatctttt tccttctgct 415681 tatcggaatc gtgtttggca cgctgttcag cagcctgtct tcttttatgc agatgctgat 415741 tgatccgaac gagttccaag ttgtgcagga caagatgttt gccagcttta acaatatcaa 415801 tacggatttg ttatggctcg cgttcatcat cttcctgctg acaggcgttt atgtctggcg 415861 ttttacaaaa tttttcgatg tgctgtcgct cggacgcgag cacgccgtga atttgggcat 415921 tgactacgac aaagtggtga agcagatgct gatcgtggtt gcgattttgg tttctgtttc 415981 aacagcgcta gtcgggccga ttatgttttt aggccttctg gtcgtcaacc tggcgagaga 416041 attcctgaaa acatataagc attcatactt aatcgcaggc tccgttttca tcagcatcat 416101 tgcgctggtc ggagggcagt ttgtggttga gaaagtgttt accttctcaa cgacgctgag 416161 cgtcattatt aattttgccg gcgggattta ttttatctac ttgctgttaa aggagaataa 416221 atcatggtag aggtcagaaa tgtaagcaaa caatatggcg ggaaagttgt tcttgaagag 416281 acgtcagtca cgattcaaaa gggcaaaatc acctcgttta tcggtcctaa cggcgccggc 416341 aaaagtacgc tgctgtctat catgagccgc ctgatcaaaa aggattccgg cgagatttac 416401 atagacggac aagagattgg agcatgtgac agcaaagagc ttgccaagaa aatgagcatt 416461 ttgaagcagg cgaaccaaat caatatcagg ctcacgatca aagacctcgt cagttttggc 416521 aggtttccgt actcacaggg ccggctgaca gaggaagact gggttcatat caaccaggcg 416581 cttagctata tgaagctgga agacattcaa gacaaatact tggatcagct gagcggcgga 416641 cagtgccaaa gggcatttat cgccatggtc attgcccagg acacagatta tatctttctg 416701 gatgaaccgc tgaacaatct ggatatgaaa cactcagttg aaattatgaa actgctgaaa 416761 cggctggtag aggagcttgg aaaaacgatc gtgatcgtca ttcacgatat caattttgct 416821 tcagtctatt ctgactatat cgtcgctttg aaaaacggcc gaatcgttaa agaaggaccg 416881 cctgaagaaa tgatagaaac atcagtgctt gaggaaatct acgatatgac catcccgatt 416941 cagacgattg ataatcaaag aataggtgtt tatttttctt aatatataga agaggtgagg 417001 agcatgaaaa agttcgcgtt actattcatc gctttggtca ctgccgttgt catttctgca 417061 tgcggaaacc aaagcacaag cagcaaaggt tctgatacaa agaaagaaca aatcacagtg 417121 aaacaccagc tcgacaaaaa cggcacaaaa gtaccgaaga accctaaaaa agttgtcgta 417181 tttgactttg gaagcttaga tacattagat aaactaggac ttgatgatat agtagcgggc 417241 ctgccgaaac aagtccttcc taaatatctg tccaaattca aggatgacaa atacgctgat 417301 gtcggcagct taaaagagcc agacttcgac aaagtggcag aattagatcc tgatctgatc 417361 attatttcag caagacaatc tgagtcttac aaagaattct ctaaaattgc gccgacgatt 417421 taccttggtg tagatacagc gaagtacatg gaatcattta aatcagacgc tgaaacaatc 417481 ggtaaaatct ttgataaaga agacaaagtg aaagatgagc tcgcaaacat tgatcactca 417541 atcgcagatg taaagaaaac cgctgaaaag cttaacaaaa acggtctcgt catcatggcg 417601 aacgatggaa aaatcagcgc gttcggccct aaatcaagat acggcctgat ccatgacgta 417661 ttcggcgtgg ctccggctga tcaaaacatc aaagcgtcta cgcacggaca aagtgtttct 417721 tacgagtaca tttcaaaaac aaaccctgat tacttgtttg ttattgaccg cggtacagca 417781 atcggagaaa catcatctac aaaacaagtc gtggaaaacg attatgtgaa aaacgtaaac 417841 gcagtgaaaa atggtcatgt catctacctt gattctgcta cttggtattt atcaggaggc 417901 ggacttgagt ctatgacgca aatgattaaa gaagtgaaag acggtttaga aaagtaaaac 417961 caaaaagagc ctccgctaaa tagcggggct ctttttttgt taatcagcgt gccggctgct 418021 gttcggcagg gcgctgaggt ttctttaatg tgaatgagag aaggaagccg acaagtgcaa 418081 tgacggcagc cactataaaa gcggcgttca tgccgtgcag ggcggcgtgc ttcacatttg 418141 tcgtgcctgc atgtgccgcc tggttgctca tcacggaaac caatagtgcg gttccgatcg 418201 agccgccgac ttggcgaatc gtgttgttca tcgcagttcc gtgcggaatc aagtggcgcg 418261 gcagcgcatt gattccggct gttgtcaccg gcatcatgat catggcggtg cctaagagac 418321 gaacggtgta taaaacgaca atccaagcga gtgacgtatg gtcagtcagc tgcataaacg 418381 gcagagatgt caggaagatg atgcagaaac cggcaatcgc cagccctctt ccgccgacac 418441 ggtcaaaaat tctgccgata atcggcgaca taaagcccat cacaacggct cccggcagga 418501 gcataagccc tgtatcaaaa gctgtgacgt ctctgacatt ttgtgtataa agcggcagga 418561 tggtttccgt accgatcaat aatgcaaaga cgagggttcc cagcagtgtt gttaagctga 418621 aaacgccaaa cgtgaagacg cggaattcca gcatcggttt tttaagcttc atttgtcttg 418681 tgataaacaa gagcagcgcg atgacaccca ccagcagtga aatcaagacg gttgaactgg 418741 accagccata agagccgacg cttgagaagc cgtacagaag gccgccgaac ccaaatgttg 418801 aaaggatgac tgataaaata tcaatctgtg tttttcttaa agtcgtcacg tttttcatca 418861 ggatgctggc aagaatcaaa tcaatcacag caaacggaag aataatataa aacaatgatc 418921 tccaagagaa agcttcgaca gcccatccgg aaagagtcgg tccgatcgca ggcgcgaatg 418981 agatgaccaa tccgaccata cccatagcct ggccgcgctt ttcaatcgga aagattgtca 419041 ggaatacagt ctgcatgagc ggcatcataa tgccggctcc agccgcttga atgatacgcg 419101 ctgtcagcag aaccgggaag ttcggcgcga acgctccgac gactgttccg gcagtgaaaa 419161 tgctcattgc tgtgatgagc agcgcccggc ttgtgaattt ctcaattaaa aacgcggtaa 419221 tcggaattaa aatcccgttg gttaacataa atgatgttgt cagccattgt gcttggttgg 419281 catcgacatt gaaatccctc atgatatggg gaagtgcagt aatcaacaat gtctggttca 419341 aaatcgccac aaacgctccg gctaacaaaa tgccgacaat gacagaacgg ttaaaaggtt 419401 tttgttcaat acttgtgttc aatacatatc ccttcttttc tctaagtaat taacagtgtt 419461 tttaacatgg aaacgggctg tgttaaaaca ccggtttgtt ccagatagcc aatcagtgat 419521 ttgagtaaaa aagcgcgggg ttcttccttc ttcgcttctt cctccagcat agcggctgcg 419581 gatgtcagtt catctacgtc atagtccgcg gcggacaggg aagagatgcc tttatgtaat 419641 tccttcaggc tttccgataa taggactgat ttatcctttg gcttgtagga ggatgctgaa 419701 tgaatataaa gctcgatggc ttcgggcgga agaagagact ggcgggtttc cctgtttttg 419761 ataatctgat tgagggtgct gatgataaac tctgcgatcg ggtcaagctc aagcggtttt 419821 tcctcgattt tgatcagcat taaaaactca cgcatcatgc cgtgaagaat gataaccaaa 419881 tcccacacaa acgggagaat ggtttctcca tacgcctgga tcagcgaatc gcggtgccag 419941 cagataatcg tcgatctggt ctgatggata tgctgtttga cccggtcatt gtgcagcttg 420001 gggtttccgt aggtcagcat attgaaaaac tgctgattcc gcctgaagcc ctccagttcc 420061 attttgacct tttgcgtcaa acgctcctcc ggtgtaagtg ctgtattttc ctgaagtctt 420121 gaggccgcgg ccaccatttg cttctggtta aatgacagca gctccaaaag cagatcttct 420181 ttagattgga acagcttata tatcgaagct tttgacatct tacattcttc tgcgatcgcc 420241 tgcatggaaa ccgacgtaaa atccttttcc gaaaaaagct ttcgcgcggc taacaagata 420301 tctgtttttt tatcaagcat ctcatggctt ccttctttct tgaacattag aaaacccatt 420361 ggttcacaga aaaccaatga gtaacaatga aaaaatttta ccagataaac aaaatagaag 420421 tcaatggatt ttaaccgggt aaatgaaagg cctgccggaa aatccgacag gccgaataag 420481 agcttatttt tcaactttaa atccttgttt ttcaagcatt tcacggatgt gcggatagta 420541 caggcgctca tagtaggaag cgatgctctg tgaccagttt cttgtttctt ttccgtttgt 420601 ccgtttattc atgtattcag acatctgttc gtcgtatgcc tgaatgtgag acgtcagctc 420661 atcctgattc aaataagttt cctgatgatt gacagcttcc tgcggcaagc gcggtttttt 420721 cgctgaacgg tcggcaggat gcccaatgac aaggccggat aaagggaaca cgtatttcgg 420781 aagctcaagc agttcgatca gctcttgagg gtttccgcga actgcaccga tcggaactgt 420841 gccaagtccg agtgactcag ccgctgctgt tgctgtgccg agggcaatac cagcgtctac 420901 tgcgccgaca agaacagatt ccaatccatt tgtgatttcc attttgaaat catgcagatc 420961 ttcaagcgca attttggccc ggttaaaatc tgcgcagaac agcaggaaaa caggagcttg 421021 atcgatccat ggctggccgc ctgccagctc ggagattttc tttttgcgct ctttatcctg 421081 gactgtgatc acagtcactt gctgtccgtt gatagaagaa ggggctgatt gcaccgcttc 421141 aatgatttgg tccaattgct cctgagctac aggctcatct gtgtagctgc gaatcgagcg 421201 gtggtctgtt aaagatttaa tcacttcatt catatgagac acccttcctt tactcgctaa 421261 gctctgtgcg gacaacatca agaggagcgc tcagcagttc ttttcctttt gcgacaaacc 421321 cttggaaatg cgcagtttcg ttatggaatt tcattgccgc ttcatctttc catttttcaa 421381 gcatgacaaa tgtattttct tcgcctactt tttcgaatag gtcgtattgc gcgttgcctt 421441 cctcagctct tgaatgctga acaagtgatt gagcctcgct caaaaattcc tcgcgttttt 421501 ctggttttac tttgatgtaa gcttgtaata cgatcatgta aatctcctcc gtcgttatgc 421561 gaatttattg ttcgaatttc atcgaactaa atgtaacatg tattctaaat gaggtaaagg 421621 aaaaaccctt atatagtaaa attgtcattc taattgttgt atgatacatt tgtgtcatga 421681 acattccaaa ccatccagaa acagaaacat tgcagctgac aaaggttctt catgcactta 421741 gtgatccgct tcgtttagag ctcgtcaagc aattagctga agcaaaagaa aaaacgtgca 421801 gcacctgtgc agatgtgcag gttgccaaat cgactttgtc gcatcatttt aaagttttga 421861 gagaatcagg catcgctcaa gttcggatag aaggaaagcg ccggtattat tcgcttcgcg 421921 ctgaagacct tgaaaaggca tttccgggac tgcttgaagc cgtgctgaat gtagaccagg 421981 accgctggtg aatcaatccc ctgtaacggg gattttttta tgtccgtaaa ccgctttgaa 422041 aagccgctgc acaccctcct gaatatcttc ttccttcagc cgtgcaaagc cgataatgag 422101 agcaggcctg cccgtttgcc gcttgttttc cttcaagtta aatcggctca ttccgaatat 422161 ttcaagctgc agcccggcag catgtgacag gatgtcttgt tcggtgcgcc tggtatcaaa 422221 ttcggtaaca aaatgcagcc ccgcatttgc cccttttacg gtaacctctc cgctgaactc 422281 tgcttctaaa gcggtgatca ggcgttctct cttttcttta taatgctgct tcattttttt 422341 tatatgcttc tgatattcac cagactcgat aaattcctgc agggtgagct gtgtgagtga 422401 tgagcaagtc tgcagatcat agccccgctg tttgtatgcc ctcaacagct caggcggcaa 422461 caccatatag ctgatccgta agccggggag aagggacttt gaaaaggttc ccatatagat 422521 gacattttga aaacggtcga ggctttgcag cgccggaata ctgtctacat catatgtgaa 422581 ttcactatca taatcgtcct caatgatata tcggcgcggc tcctcggctg cccagttcag 422641 cagctgaatt cttctggata caggcataat cgttccggac ggaaactgat gcgacggggt 422701 ggtcaccagc acatctggct gctgtctggt gatttcagca atcgacatgc ctttttcatc 422761 cagcatgatc gtctttactt gttttccggc attcttcaaa agctgataca tgcgcctgta 422821 gccaggctcc tccatcgcat acacggcttc cttgggtaaa agctcagtca acagctgcat 422881 gagcacctgt gtgcctgccc ctatgatcat ttgttccggc ctgcatttta cacccctcgt 422941 cagggaaatg agcctcgtaa tggccgctct cacttcatat atcccttgcg gatgtgacat 423001 atcgccgagc gtgcggtatg agcgggaggc cgctttttgc tcgcagcgga accagctttt 423061 gatcggaaaa tggtctgtat cggaactcat gtgtgaaaac gatatccaat cgctctggtc 423121 gatgtgaatc tcttttaggt catccggcag tgcaaatgga gggtgctcct cggcggaaaa 423181 catgtctagt tcctccacga agaaaccctt tcgttcaatg gcgtacaaat acccctcagc 423241 cagcagctgc tgataggctg aattcactga atttacgctg accttgagat tttcagccag 423301 ctcccgcttg gagggaacct tcgagtgcgg cagcagattg cggctgagga tttctttttt 423361 cagcttttga taaatttgct gatagatata atcggcttgt tctgaacgat cgagtgtaat 423421 cgtgatatcc attttgtagt ttctccttct gataccatca aaaagttata attggtactt 423481 ttcatcatac caaagagaag tcagaatgat aagaaaatac cgacaggggg atattcacat 423541 gagtcaaaca acagcaagca tcacaactgc acaatggcag caaaaacggg atcaatttgt 423601 gtcaaaaggt gtgagcaacg gcaaccgcag tctggcggtc aaaggagaag gggccgagct 423661 gtacgatctg gatggccgga gatttattga ttttgcaggc gccatcggca cgttaaatgt 423721 cggacactcg catccgaagg tggttgaggc tgtgaagcgg caggcggagg agctgattca 423781 tcctggtttt aatgtcatga tgtacccgac ttatatcgaa ttagcagaaa aactgtgcgg 423841 catcgcgccg ggcagccatg agaaaaaagc gatttttctt aactcagggg cagaagcggt 423901 cgaaaacgct gtgaaaatcg ccagaaagta tacaaagcgc caaggcgttg tctcgtttac 423961 acgcgggttt cacgggcgca cgaatatgac gatgagcatg acaagcaagg taaaacctta 424021 taaattcggt ttcgggcctt ttgcgccaga ggtttatcaa gcgccgttcc cttattatta 424081 tcagaagccg gccggcatga gtgatgaaag ctatgacgat atggtcattc aagcattcaa 424141 tgatttcttt atcgcttcag tggcgcctga aacggtggcg tgtgtcgtga tggagccagt 424201 gcagggagaa ggcggattta ttattccttc gaaacggttc gtacagcacg tcgcttcatt 424261 ctgcaaagaa cacggcattg tttttgttgc tgatgaaatc caaaccggct ttgccagaac 424321 tggcacttat ttcgcaattg agcactttga tgtagtgccc gatctgatca cggtttctaa 424381 atcgcttgcg gcaggcctgc cattaagcgg tgtgatcggg cgtgcggaaa tgcttgatgc 424441 ggcagcgcca ggggagctgg gcggcacgta tgccggcagc ccgctcggct gcgcggcggc 424501 tttggcagtc ttggatatta tcgaagaaga aggactgaat gagcgatctg aagaaattgg 424561 caaaatcatt gaagacaagg cgtatgagtg gaaacaagaa ttcccgttca tcggtgacat 424621 ccgcagactc ggggcgatgg ccgcaatcga aatcgtcaag gatcctgaca cgcgtgagcc 424681 tgataagaca aaagcagcag cgatcgcggc ctatgcgaat caaaacggat tacttttgct 424741 gacagcggga attaacggta atatcatccg ctttttgaca ccgctcgtca tctcagacag 424801 cctattaaat gaagggctca gcatcttgga ggcgggcctg cgagcttaat cattggaaag 424861 aaaatggccg ggtctgctat cattttaagt aatcatgaaa agaaaggaat gttcaatatg 424921 ccagatcaat taacggtcta caacccggct acgggcgagg agatcaaaac gattcctcag 424981 caatcagcca cagaggtaga agaagccatt gaacgttcac atcaagcgtt taaaacgtgg 425041 tctaaaacat cagcgaacga aagaacgtct cttttgaaaa aatggtatga gctgattgtt 425101 gaacataaag aagagcttgc agatttaatt acaaaggaaa acggaaaacc ataccaggaa 425161 gcagtcggcg aggtacttta cggcgcaggc tatatcgaat ggttcgcaga ggaagcgaag 425221 cgtgtgtacg gaagaacggt cccggccccg acaactggta aacgaattgt tgtcacacgc 425281 cagccggtcg gccccgttgc tgctatcacg ccctggaatt tcccgaatgc gatgattaca 425341 cgcaaagcgg cgcctgctct tgccgccggc tgtacattta tcatcaagcc ggcgccggac 425401 acaccgctgt ctgcttatga actagcgcgc ctcgcatatg aagcgggcat tccgaaggat 425461 gttcttcagg ttgtgatcgg cgatggagaa gaaatcggaa atgtgttcac aagcagtccg 425521 aaaatccgca aaatcacgtt cacaggctca acacctgtag ggaaaatcct tatgaaaaac 425581 agcgctgaca ccgtaaagca cgtctcaatg gagctcggcg gacacgcccc gctgatcgta 425641 gatgaagatg cggacattga ccttgccgtt gaacaggcga tggcgtccaa ataccgaaac 425701 gccggccaaa cctgcgtatg tgccaaccgc ctgatcgttc atgaatccat taaagatgaa 425761 tttgctgcga aactgagcga gcaagtgtct aagctgaaag tcggaaatgg acttgaggaa 425821 ggcgtcaatg tcggcccgat tatcaacaaa cgaggcttcg aaaaaatcgt cagccaaata 425881 gatgatgcgg ttgaaaaagg cgcgaaagtg attgctgggg gcacatatga ccgaaacgat 425941 gacaaagggt gctactttgt gaatccgaca gtgctcaccg atgtcgatac gtccatgaac 426001 atcatgcatg aggaaacatt cggcccggtc gccccgatcg tcacgttttc tgatattgat 426061 gaagcgattc agcttgccaa cgatacaccg tatggcttgg ctgcttactt cttcacagaa 426121 aactaccgcc gcggcatcta tatttccgag aatctagagt atggcattat cggctggaat 426181 gacggcggac cgtcagcggt tcaagcgcca ttcggcggaa tgaaagaaag cggcatcggc 426241 cgtgaaggcg gttcagaagg tatcgagccg taccttgaaa caaaatattt gtccatcggt 426301 ttataaaaga atgcacgctc ctgagagctg ccggattttc cggcagctct ttttgtgttc 426361 cggcgaataa tcacaacaat tccagccaaa ataacagcaa atacattttg aaagaaggtt 426421 ccccaacaat ggatttatta ttggctcttc tcccggcttt gttttggggg agcattgttc 426481 tcttcaatgt gaaattaggc ggcgggccgt acagccagac actgggaacg acgatcgggg 426541 cactcattgt ttctatcgtt atttactttt ttgttcagcc cgttctgtcc cttcgcattt 426601 ttattgttgg aatcgtatcc ggcttatttt ggtcacttgg acaggccaac cagttgaaaa 426661 gcattcaatt gatgggcgtg tcgaaaacaa tgccgatttc cacaggaatg cagctcgttt 426721 ccacctcgct gttcggtgtg atcgtgttcc gcgaatggtc aacaccgatt gcgattacgc 426781 ttggcgttct cgctttgatc tttatcattg tgggaatcat tctcacgtcc ttggaagata 426841 agaatgataa aaaagagggc gagccaagca atttgaaaaa gggcattttg attctccttg 426901 tttcgactct tggttatttg gtttatgtag tcgtggctag attattcaat gtgtccggct 426961 ggtccgcgct gctgccacag gcaattggca tggtggtcgg ggggttagtt ttaacctata 427021 gacacaaacc ctttaacaag tatgcgatca gaaatattct cccagggtta atctgggcag 427081 gcggaaatat gtttttgttt atttctcagc cgcgagtcgg cgttgcaacg agcttttccc 427141 tttcacaaat gggaattgtc atttctacgc tcggcggtat tttcatcctg cgtgaaaaga 427201 aaacgaaacg ccagctaata gcaattgcga tcgggattat cctgattatt gccgccgccg 427261 tattcttagg aatcgccaaa acaaattcat aacaaatgga ggaggatgta tatgtatccg 427321 gatttaaaag gaaaagtcgt cgctattaca ggagctgctt cagggctcgg aaaggcgatg 427381 gccattcgct tcggcaagga gcaggcaaaa gtggttatca actattatag taataaacaa 427441 gatccgaacg aggtaaaaga agaggtcatc aaggcgggcg gtgaagctgt tgtcgtccaa 427501 ggagatgtca cgaaagagga agatgtaaaa aatatcgtgc aaacggcaat taaggagttc 427561 ggcacactcg atattatgat taataatgcc ggtcttgaaa atcctgtgcc atctcacgaa 427621 atgccgctca aggattggga taaagtcatc ggcacgaact taacgggtgc ctttttagga 427681 agccgtgaag cgattaaata tttcgtagaa aacgatatca agggaaatgt cattaacatg 427741 tccagtgtgc acgaagtgat tccttggccg ttatttgtcc actatgcggc aagtaaaggc 427801 gggataaagc tgatgacaga aacattagcg ttggaatacg cgccgaaggg cattcgcgtc 427861 aataatattg ggccaggtgc gatcaacacg ccaatcaatg ctgaaaaatt cgctgaccct 427921 aaacagaaag ctgatgtaga aagcatgatt ccaatgggat atatcggcga accggaggag 427981 atcgccgcag tagcagcctg gcttgcttcg aaggaagcca gctacgtcac aggcatcacg 428041 ttattcgcgg acggcggtat gacacaatat ccttcattcc aggcaggccg cggttaaaca 428101 taaaaagcga cccagacatg acatctggat cgctttcttt attaggcacg ctttttcttt 428161 acaagtgctg ctacagataa aataatggca gccgcagaca gcaccatcgc tgtaatgtct 428221 agagctgaag aacctgagtt ttcggaatcg tcttctgttt tcgtggcgcc gtgctcatct 428281 gtcacttgct ttgcagacgt gatgtttgta atggaatgag gtgtatcggc atcctcgtca 428341 cctgtccact caacaatgct gccgtctttg taatattggt atgcgtccca agcagcttcc 428401 tccgctttgt cagggttttt ggcaacaaag gtaaactgct ggaactggcc ttcctgaatg 428461 cctccgtcag tcgcctccca tgtcacggat actgatttgt catcatgttt ttgagtggaa 428521 accttccagc ccggaattgg ctcatattgc tggaattcaa catccttcgg cattttgagg 428581 acaaccttcg ttgtcggcag atttttctca gaaggaacct tcattgtata cgtttcccaa 428641 gagcctgcag cagactcagc cggttttaca gaaacatgcg cgctggcagg ggccgtaaag 428701 aataagaggg agccgacaat agccggacat agtgtcaatg cgattttttt caacaacgta 428761 aacactcctt aattggtctt tgtaaacatg atattgattt cgttaaagtc gccggtcagg 428821 ccgtggactt tgatcttcca gtttcctttt tcattaatcg acaggttttg atcttggaag 428881 acgccttttg ttttttcttt taatgtaaag gtgcttttgt tttcgctgcc tgacaggcct 428941 gttttataaa cggttaacgt gatttgctgg atgtttttca cgggatcacc gttatggtcg 429001 gtgacccgca gctcaaaaac attttttcca ggctggtttg ggctgatgct gagagaaacg 429061 ctttgtccgt tctctatcgc tttggtttgg tagaacggtt ccggcgctgg ctcaggcggg 429121 cttggcaggc ttgtaaacac ggccgctgtg atcaatacag cgatgccgat tgcccactcc 429181 gctttcaacg ttcggctgat tcctgtgcgg cgctgctttc tggtaagcag aaaatgaatt 429241 gcgcctaaga ccagcatgaa aacaaacagc ccgcttttca ctaaaagagc ttgtccgtac 429301 gctgtatgga acagtgaatc cattgaacga atgatgaaaa atccattgag caagcctgaa 429361 aacaaaatga cgccgactgc agtgagcgcc catggggaga accgtctgac cgtctcccac 429421 gcgagcgttt tgtcaggctg cctccattct tttgagagca gcaaaacgag tgccgctatt 429481 ccgccgaccc agatggaagc ggaagttaaa tgaaggaaat ccatcaaaat gccgaccgtt 429541 ttttcttcaa cgacagcagc atgcccggta aacgccttgg caagcaggag accgaaaaag 429601 aaaatgagcg gcgctgtcca atagccaaag gatgaaaagc ggtttttccg tatcgcaggg 429661 atgacagaca gtgcgagcag cacgaacagc gcagcctgta tgatccaaat ggagccgcct 429721 gctgtctcaa acagtgtttc tctgatgtag cccggctgga atgcgctgcc ccagccgccg 429781 cctgcgttcg cttttgtctg aatcggaagc tgaagcaaaa gcgccagccc caatgctgcg 429841 atcgagccgg tcaggatacg tctcgtccgt ttgacgagct gttctgattt ccctttatac 429901 cagaaaagat ggaagaaaac cgttccgata aacagagata aggctgtata cagaatcgcg 429961 cgatctgctg ctgttcccgg attcagcgct gaatcggctg ctttttggct gctgaatccg 430021 ccatccgctt tcccgatact gaacggaatg acgccggaaa caggatgtcc atccgcggat 430081 acggcattcc attccgctct gtacacatct ttaggcagat tcttcttcag cttcactgtc 430141 atgatgtgat gattatcttt tttgatttca gtcttgtccg tatccacacg gtcgccgttt 430201 gaattataga ctttaatgta atgaaaccct tcttcaaccg gttcattaaa ttcgatttcc 430261 acctgcgcag gggcgctttt taattcgctg ttttccccag gtgaagattt gacaatatag 430321 gcgtgagcaa agcttgtttt cggcaggaaa acaagaaaaa gcagaaggat gatccaccat 430381 ctgtttcgct tcatcactca gacaccacct tccgctgtat gtgttgtgtt atttcttggt 430441 gcaggtgcag cgtttctttc ggtcttgaag catgtcttcc agcgcttggt cgaaagtgca 430501 gacggctccg ccgaatcctt tttgaaatcg ttcggcatgg tcaagtgtcg caaacggaat 430561 ggcctgcggc tggcagcagt gcaggtttaa ttcagcattt acgacgaaat aagccgaacc 430621 ggcactgacg gttgtctgta acagaaaatc tctgcaaatc aagtgtgaaa cctcttccgt 430681 tttatccgcg taacgcaaaa acgcgcaatg tgcgcagcat agctgttcaa tgtcttggtt 430741 taccgtaatc agctgaaccg aatgagcttg attgacgggc ttcaagcaat agctgcacat 430801 atgatctgtt tgaggtgttc ggacggggag cgtgatgccg ccggccgttt taatgacctg 430861 atttgactga accagctgat tgacatctct atataccgtc atttccgaaa cgccgaacct 430921 tgcgctgatg tcagaaattc taagcgagcc ttcttctttc agccacttca gtatgtgttg 430981 ctgtctatta atcggaagca ttcatacacc ctcttcatta agatctattt aagcgtagag 431041 gattttagag acggagacaa gtaagtggat gataaaaaat gtgaaaatgt gttgaacagc 431101 aacaaaacga aacagaaggg actctggtat aatagacaga tggaatagaa agtgaggaat 431161 accctatgaa agaaacacca tgcccgaact gcggcaaacc tttgacaggc gatatggtca 431221 gatcatcaaa tgtgccttgt caatttcgct gcggccactg ccgggaacgg ctttatgaat 431281 ataaagtttc agctccgatt atgctggtat cattagcggc catcgtgctg cttatttatc 431341 ttttgatgct cctccgcaat gcggcaggct cagtgctgcc agctgtacag cacgtgccga 431401 tggctgtatt tgcgcttgtg tgcgcgtatc ccgtttttat tgtgagtgag cggatgattg 431461 caaagtacgt gattcaaaat ggcaacatca tttatagagg aaagagaaaa ggctcctgaa 431521 accaggagcc tttttatttt taaaaaattg tcacagtcat gtgccaaagt cctctttact 431581 ttcaattgta tagggactgt aagcgtttta acatagagtc aaagggaagc atcattctct 431641 gaacatattt ttgtatctta cagcgacaaa caaaacaggg agggtttata tatgcagcag 431701 caagaacagc agcaaggcgg catgaaagtg aaagtgcaac gctttgggag ttatttgagc 431761 ggaatgatca tgccgaatat cggcgcgttt atcgcgtggg gtatcattac cgcgctgttt 431821 attccggcag gatggtttcc gaatgaacag ctgaacacgc tggtcagccc gatgattacg 431881 tatttattgc cgcttttgat agcgtataca ggcggaaaaa tgatctacga ccaccgcggc 431941 ggagttgtcg gagcgacagc ggcaattggg gtgattgtag gatcggatat tccaatgttt 432001 ttaggcgcaa tgattatggg tccgcttggc ggatacctca ttaaacagac tgataaatta 432061 ttcaaggata aagtcaagca aggctttgaa atgctgatca acaactttac ggcagggatt 432121 gtcggcgcgg ctttaacgat tctcgcgttt tacgccatcg gcccggttgt cttgacgcta 432181 aataaattgc tggcggctgg tgtggaagtc attgtacacg ctaatttact gccggtagcc 432241 agtgtttttg tagaaccggc gaaagtgttg ttccttaaca acgccataaa ccatggaatc 432301 ttaagcccga tcggaatcga gcaagcatct caaacaggaa aatcaattct gtttttagta 432361 gaagcaaacc ctggaccggg gctcggcatt ttgctggcct acatgttctt tggcaaagga 432421 tcttcaaaat caacggctcc cggtgcggcg atcatccatt tcttcggagg gattcacgag 432481 atttacttcc cgtacattct gatgaaaccg gccctgattc tcgcagccat tgccggcgga 432541 gcaagcggac tcttaacatt tacgatcttt aatgccggac ttgtcgcggc agcgtcaccg 432601 ggaagcatta tcgcattgat ggcaatgacg ccaagaggag gctatttcgg cgtattggcg 432661 ggtgtattgg tcgctgcagc tgtatcgttc atcgtttcag cagtgatcct gaaatcctct 432721 aaagctagtg aagaagacct ggctgccgca acagaaaaaa tgcagtccat gaaggggaag 432781 aaaagccaag cagcagctgc tttagaggcg gaacaagcca aagcagaaga agcgtctgag 432841 ctgtctcctg aaagcgtgaa caaaattatc tttgcgtgtg atgcgggaat gggatcaagt 432901 gccatggggg catccatctt aagaaacaaa gtgaaaaaag cggagcttga catcagtgtg 432961 accaacacgg ccattaacaa tctgccaagc gatgcggata ttgtcatcac ccacaaagat 433021 ttaacagacc gcgcgaaagc aaagctgccg aacgcgacgc acatatcagt ggataacttc 433081 ttaaacagcc cgaaatacga cgagctgatt gaaaagctga aaaagtaatc ttatagaaag 433141 agagtgattg tcatgcaagt actcgcaaag gaaaacatta aactcaatca aacggtatca 433201 tcaaaagaag aggctatcaa attggcaggc cagacgctga ttgacaacgg ctacgtgaca 433261 gaggattaca ttagcaaaat gtttgaacgt gaagaaacgt cttctacgtt tatggggaat 433321 ttcattgcca ttccacacgg cacagaagaa gcgaaaagcg aggtgcttca ctcaggaatt 433381 tcaatcatac agattccaga gggcgttgag tacggagaag gcaacacggc aaaagtggta 433441 ttcggcattg cgggtaaaaa taatgagcat ttagacattt tgtctaacat cgccattatc 433501 tgttcagaag aagaaaacat tgaacgcctg atctccgcta aaagcgaaga agatttgatc 433561 gccattttca acgaggtgaa ctgacatgat cgccttacat ttcggtgcgg gaaatatcgg 433621 gagaggattt atcggcgcgc tgcttcacca ctccggctat gatgtggtgt ttgcggatgt 433681 gaacgaaacg atggtcagcc tcctcaatga aaaaaaagaa tacacagtgg aactggcgga 433741 agagggacgt tcatcggaga tcattggccc ggtgagcgct attaacagcg gcagtcagac 433801 cgaggagctg taccggctga tgaatgaggc ggcgctcatc acaacagctg tcggcccgaa 433861 tgtgctgaag ctgattgccc cgtctatcgc agaaggttta agacgaagaa atactgcaaa 433921 cacactgaat atcattgcct gcgaaaatat gattggcgga agcagcttct taaagaaaga 433981 aatatacagc catttaacgg aagcagagca gaaatccgtc agtgaaacgg taggttttcc 434041 gaattctgcc gttgaccgga tcgtcccgat tcagcatcat gaagacccgc tgaaagtatc 434101 ggttgaacca tttttcgaat gggtcattga tgaatcaggc tttaaaggga aaacaccagt 434161 cataaacggc gcactgtttg ttgatgattt aacgccgtac atcgaacgga agctgtttac 434221 ggtcaatacc ggacacgcgg tcacagcgta tgtcggctat cagcgcggac tcaaaacggt 434281 caaagaagca attgatcatc cggaaatccg ccgtgttgtt cattcggcgc tgcttgaaac 434341 tggtgactat ctcgtcaaat cgtatggctt taagcaaact gaacacgaac aatatatcaa 434401 aaaaatcatc ggtcgctttg aaaatccttt catttcggac gatgtgaccc gcgtagcgag 434461 gtcacctctc agaaaactgg gagaaaatga tagacttgta ggcccggcaa agaaaataaa 434521 agaaccgaat gcactggctg aaggaattgc cgcagcactg cgcttcgatt tcaccggtga 434581 ccctgaagcg gttgaactgc aagcgctgat cgaagaaaaa ggatacagcg gcgtacttca 434641 agaggtgtgc ggcattcagt cccatgaacc gttgcacgcc atcattttaa agaaacttaa 434701 tcaataaccg accacccgtg acacaatgtc acgggctttt tttactatct cgcaatctag 434761 tataatagaa agcgcttacg ataacagggg aaggagaatg acgatgaaac aatttgagat 434821 tgcggcaata ccgggagacg gagtaggaaa agaggttgta gcggctgctg agaaagtgct 434881 tcatacagcg gctgaggtac acggaggttt gtcattctca ttcacagctt ttccatggag 434941 ctgtgattat tacttggagc acggcaaaat gatgcccgaa gatggaatac atacgcttac 435001 tcaatttgaa gcagtttttt tgggagctgt cggaaatccg aagctggttc ccgatcatat 435061 atcgttatgg gggctgctgc tgaaaatccg gagggagctt gagctttcca ttaatatgag 435121 acccgccaaa caaatggcag gcattacgtc gccgcttctg catccaaatg attttgactt 435181 cgtggtgatt cgcgagaaca gtgaaggtga atacagtgaa gttggcgggc gcattcacag 435241 aggcgatgat gaaatcgcca tccagaatgc cgtgtttacg agaaaagcga cagaacgtgt 435301 catgcgcttt gccttcgaat tggcgaaaaa acggcgcagc catgtgacaa gcgccacaaa 435361 gtctaacggc atttatcacg cgatgccgtt ttgggatgaa gtctttcagc agacagccgc 435421 tgattatagc ggaatcgaaa catcatctca gcatattgat gcgctggccg ctttttttgt 435481 gacgcgtccg gaaacgtttg atgtcattgt ggcgagcaac ttgttcggtg atattttaac 435541 cgacatcagc tcaagcctga tgggaagcat cggcattgcg ccttctgcga acatcaatcc 435601 atccggcaaa tatccgtcca tgtttgaacc ggttcacggc tcagctcctg acattgccgg 435661 acagggcctt gccaatccga tcggccagat ttggacagcg aagctgatgc tcgaccactt 435721 cggagaggaa gaattggggg cgaaaattct ggatgtaatg gagcaagtga ctgccgacgg 435781 catcaaaaca cgcgacattg ggggacaaag cacaacggct gaggtcactg atgaaatctg 435841 ttcgcgctta agaaagctct gatgaatcag gccggtggca gatggctgcc ccggcctgtc 435901 catttcctta cgaaaatttc cacgaaagtc taaccaagca gatccaaatg ctgtataata 435961 atttggaatt cttaggaaag catcgggtga aggaagttga atgcaaaaac aatcacgtta 436021 aagaaaaaaa gaaaaatcaa aacgatcgtt gtactcagta tcattatgat cgcagctctc 436081 atttttacga tcagattggt gttttacaag ccttttctta ttgaaggatc atcaatggcc 436141 ccaacgctta aagactcaga aagaattctg gttgataaag cagtcaaatg gactggcggg 436201 tttcacagag gagacatcat agtcattcat gacaaaaaga gcggccgctc atttgtcaaa 436261 cgtttaatcg gtttgcctgg tgacagcatt aaaatgaaaa atgatcagct atacataaat 436321 gataaaaagg tggaagaacc atacttaaag gaatataaac aggaggtcaa agagtcgggt 436381 gtaaccttaa caggtgactt cgaagttgag gttccttccg gtaaatattt tgtgatggga 436441 gataaccgtc tcaattcact ggatagcaga aacggaatgg gcatgccttc tgaggacgat 436501 atcatcggta ctgaatctct cgtcttttat ccattcggtg agatgagaca ggcaaaataa 436561 aatgcaatgc aaaaagaaca tggaacatga cggcaccgat aataaagcgc cgtgcacgtt 436621 taaaaaaatg atgatgaaac ggtgcggagc cggctttccg ccccgttttt tatgatagaa 436681 agcgttttga agaaaagggc cctgttgaaa taaacagaat caggattggc gaagccgtga 436741 agcgcatcga attggtaaat ctcaagatgg gtatgctgtt tttcccgcag ttttttgata 436801 agaagcgcta cgtcaaacga cggctcataa ttagggaaaa acaataggac cgggcaggct 436861 ggcatgtgat gaagagagtc gcgtatccgg gaaccgtaat aacaaaccga tccgctcacc 436921 tcaggcatac tgctgcattt ccatgcgata gtagccccca cgctgaatcc aatcacaaag 436981 atgtgccgtc cggcgttttg cctgatcaca ttctggatga tggtttctcc cgttttcagc 437041 ctttcgtgtt ttgtaaattg ttcgtatgcc gttttttctt ctttcagtgt gtagacttca 437101 tcctcgccga gcaggttggg cgtcaacaca tcatatccag ccattttgat cagccggccc 437161 atctttttca tatggctgtt tacaccatat atttcgtgtg cgagaatgac aagcggtttt 437221 gggaacataa cggcctcctt ttgtgttttt tccattatat cctatcgttt cactttaggc 437281 tgagatataa tggtcaaaaa aaggagatat aaaatgaact cattatcttt gcctcaccgc 437341 tatccatttt tgtttattga tggcgtgacg gatagcgagc ccggcaaaca tgcggcagct 437401 tataagctga ttagtgagaa cgactggttt atcactgata cgcaaacaga aatgccgttt 437461 tcacttgtga ttgaagcgct tgcgcaaacc gcggctttta caggaattac agatgagaac 437521 agcttgggat tattgtcttc ggtgaagaaa gcggaaaagc tgggagaagc tgtgcctggt 437581 gaccggcttg atcttacgtt tgaagtcacg cgcaatcggc gcgggtttgt gttcggacat 437641 gccaaggcat cagttggaga gcagcctgtt gctgaagctg aaatcggcat ctatattgaa 437701 aaatgaaaaa aacccttcac aacattttgt gaggggttct attttgtgtc gtaatcccgt 437761 tcgctttgag agttatctct ttgctggcgt ttgtgttttt catcattcat attttccttc 437821 agctcttcat taggaatcgg atcggttaag tcgttgtgct cggggttttc atttggtttg 437881 ttttgctgtt ttttttctgt catgtttgat cacctcaccg tttgttttcc tcttattcat 437941 tctcctcaaa cataggaaat cgcttttttg tcccgctggg tataatgtat tagaatagag 438001 agaagcacaa caaaaagata aagagaggta catatatgtc tgttcaaaga gaagatgtag 438061 atatcaagct gatcgcaatt gatatggatg gtacactgct gaacgacgag cagctgatct 438121 cggatgaaaa ccgcaaagcc attcgtgaag cggaggataa aggtgtgtat gtggtgatca 438181 gcacgggccg gacgctgatg acgtgcaggg agctggcgga atcgctaaag ctgtcatcct 438241 ttctaatcac ggcaaacggc agtgaaattt gggattcgaa ttttaatttg gtggaacgga 438301 agctgcttca tacggaccat attcaaatga tgtgggattt gcggaataag cacaacacta 438361 atttctgggc ttctacggtg aataaagtat ggagaggcga gtttccggaa aacattacgg 438421 atcatgaatg gctcaaattc ggctttgaca tcgaggatga cgatatccga aacgaagtgc 438481 ttgaggagct gagaaaaaac aaagagctcg aaatcacaaa ttcaagtccg acaaacattg 438541 aagtcaacgc gcttggcatc aacaaagctg cagcccttgc caaggttacg gaaaaactcg 438601 gctttacaat ggagaatgtg atggcgatgg gcgacagcct taatgacatt gcgatgatca 438661 aagaagcggg tcttggcgtc gcaatgggca atgcgcaaga catcgtaaaa gaaacggctg 438721 attatatcac ggatacaaat attgaggatg gtgtcgctaa agcgattcgc cattgggtac 438781 tataaaaaaa gagagtccta agatggactc tcttttttag tttggcaggt tttattctgg 438841 gaccatggta ggttttctga caaaagtatt tcacaaactg atatgattca cttataatga 438901 aataaagttc aaaaattcgg aatagtcgtt ccgaatttcg ggacaataaa tgacataaag 438961 catatcgttt gctttggcag gagggattct gtgtttcaga ttgatttaaa ctgtgattta 439021 ggagaaagct tcggagccta caagataggc cttgaccaag atattttaga gtatgtgaca 439081 tcagcgaata tcgcatgcgg atttcatgca ggagatccta gtgttatgcg aaaaaccgtc 439141 gcgcttgcag cagaaagagg cgtgaaaatg ggtgcgcatc cgggcttgcc ggatttactc 439201 ggttttgggc gccgcaatat ggcgatttct cctgaggaag cgtatgatct tgtcgtttat 439261 caaattggcg cgctctctgg ctttctaaaa gcagagggac ttcacatgca gcacgtcaag 439321 ccgcatggcg ctttatacaa tatggcggca gtcgatcaaa aactgtcgga tgctatcgcg 439381 aaagctgtct ataaggttga tcccggcctg attcttttcg gtcttgctga gagcgagctt 439441 gtaaaagcgg gagaacggat cggacttcag accgcaaatg aagtgttcgc cgacagaaca 439501 taccaatcgg acggcacgct gacaccgcgc tcccagccgg acgcactcat tgaaagtgat 439561 gatgccgccg tcacccaggt catcaaaatg gtgaaagaag gggcggtcaa atctcagcaa 439621 ggacatgatg tgtcattaaa agcagataca gtctgcattc atggagatgg agcccatgcg 439681 ctgacatttg cgcaaaaaat cagaaaacag ctcaaagcgg ctggaattga agtgacagct 439741 atttcagaac agaggtcaac ataaaggagg aacaatagat ggagcagcag aaaaagacag 439801 caggaaaaaa agcgggcagc tggtcattgc tgatgggcgc cgccttttta atggcgacat 439861 cagcaatcgg accgggtttc ctcacccaaa ccgcaacatt cacaaacaca ctcgcagcaa 439921 gcttcggttt tgtcatctta atctctatta ttttagatat tttcgcccaa accaatgtgt 439981 ggcgcatcat cgcagtttct ggaaaacgag gtcaggaaat tgcgaatatg gtgcttcccg 440041 gactggggta tttcatcgcc attctcgtcg tgcttggcgg actagctttt aatattggga 440101 atatcggagg ggccgggctg ggacttcagg tgctgttcgg cattacacct gaaacaggcg 440161 ctttaatcag tgccgttatc gccattttga tttttgtcat caaggaagca ggaaaagcga 440221 tggaccgttt tacgcaaatc gcggggttcg tgatgattat tttaacggtc tacgttgcgg 440281 cgacgacagc tcctccggtc ggacaggcag tcgcaaatac attcgtcccg gaacacatca 440341 gcatatttgc cattgtcacc ctagtgggcg gaaccgtcgg cggttatatc acatttgccg 440401 gaggacaccg tttgcttgat gccggaatta aaggaaagga atccattccg caggtgacaa 440461 agagctcggt tgtcggcatt ttaattacat ctgtcatgcg tatcgctctt tttcttgcgg 440521 ttctaggcgt tgtatcgaaa ggcctgcaca tcgatgaaag caacccggcg gcttctgtct 440581 tcaagctggc tgctggaaat gtcggttata aaattttcgg attgatcatg tggtctgcgg 440641 cgattacgtc tgttattgga gcagcctata catctgtttc attttttaaa accttttctc 440701 caaaaattga aaagaattca cgcggtatta ttatcggatt tattgtggtt tctacgttag 440761 cttttgtcac aatcggccag cctgcgaaga tcctcgtcct tgtcggttca ctgaacggct 440821 taattctgcc gattgcgctc ggaacgctgc ttgttgccgc ctacaagaaa aacattgtcg 440881 gtgattataa gcatccgctt tggctgacaa gcacaggcgc gcttgtagtg attgtaatgg 440941 cagttatggg aatctacacg ttatgtacac aacttcctca attgtggagc tgatataagt 441001 ggagcaatta aacaaaatgg cgccaaagga tgtacgcgcc ctgatacgag aggggaaaat 441061 aaacgggccg accgcaggca tgtccggcgg ctacgcccaa gcgaatcttg tggttttgaa 441121 aaaggacctt gcgtttgatt ttctgctgtt ttgccagcga aatcaaaagc cctgccccgt 441181 gctggatgtg actgaagcag gttcgcctgt gccgtctctg gctgcgccgg atgctgatat 441241 cagaacggac tttccgaaat accgtattta caggcacggt atcctaacgg aagaagtatc 441301 tgatattacg ccatactggg aggacgattt tgtcggcttt ctgatcggat gcagtttctc 441361 ctttgaacag gcactgatca ataatgggat agctgtccgg catattgatg aggggacaaa 441421 cgtctcaatg tataaaacga atatcgattg tgttccggcg ggggcgtttc acggacagat 441481 ggttgtcagc atgaggccgg ttcctgaacg gctggctgta cgtgctgcac aagtgacctc 441541 gcgttttccg gctgtgcacg gagggccgat ccatattggc aatccgggag caatcgggat 441601 tcgcgatctc gggaaaccgg atttcggaga tgccgtttcc attcgtgacg gcgaggttcc 441661 tgttttttgg gcatgcggag tgaccccgca agccgtggct atgaatgtaa agcctgaaat 441721 ggtcatcaca catgcgccgg ggcatatgct catcacagat attcgagacg agtcgcttgc 441781 ggtgctgtag cctctcgtca tcctgatgaa cgagaattaa aagaggtgag aaagatgact 441841 gtacgatatc aaatcgaaca gctcggtgat tctgcaatga tgatccgatt cggagaagaa 441901 atcaatgaac aggtcaacgg cattgtccat gcagcggccg cttatataga agaacagcca 441961 tttccgggat tcattgaatg tatcccggct tttacaagtc taaccgtatt ttatgatatg 442021 tatgaagtgt acaagcattt gcctcaaggc ataagctcac cttttgagag tgtcaagcgc 442081 gatgtcgaag agcggctggc agaaatagcc gaagactatg aggtcaaccg ccgtattgta 442141 gaaattcccg tttgctatgg cggtgaattc ggtccggatt tagaagaggt ggcgaagatc 442201 aatcaactgt caccggagga agtaatcgac attcatacaa acggtgaata tgtggtgtat 442261 atgcttggct tcgcgcccgg ttttcctttt ctaggcggga tgtcaaaacg cattgcagct 442321 ccgagaaaat catcgccaag accgtcgatt cccgcaggtt cggtcggtat tgcgggattg 442381 cagacaggcg tttatccgat ttcaacgccg ggcggctggc agctgatcgg caaaacgccg 442441 ctggctcttt tccggccgca ggaaaacccg ccgacattgc tgcgggcggg agatattgtg 442501 aaattcgttc gcatctcaga aaaagactat cacgcctata aggaggagtc caattgagca 442561 tgaaagtatt aaagcccgga ctgctcacaa cggttcagga tataggcaga acgggttacc 442621 aaaaatacgg cgttctggcc agcggcgcta tggacacggt ttcactgcgc attgccaatc 442681 tgttgatagg aaacggcgaa aatgaagcag gtctcgaaat aacgatgatg gggcccggtc 442741 cgtcgtttca tttttcaaaa cagacactga ttgctgtgac aggggcggac ttcacgctgc 442801 gtattaatga cgaggaagcg cctttatgga agcctgtgct catcaaggaa aacagcacgg 442861 tcagctttgg cccctgcaaa ctcggcagcc gtgcttattt ggcggcagct ggcggcattg 442921 aggtgcctgc cgtcatggaa agtaaaagca catacgtcag aggaagcatt ggcggacttc 442981 atggcagagc gcttcaaaaa gaagatgaac tgaacattgg agagatgtca gctctttcgc 443041 aaaccatcct ttctcgctta agttcgcagc ttggaaaaca gggatttgca gcaccgaagt 443101 ggtcagtcag ccgcggcaga tttctgccat tgaagaagaa tcccgtcatt cgggtgctgg 443161 aaggaaagca atttgccttt ttcacagaag aatcaaaaac gcgtttttat gaagaagcat 443221 ttcgtgtcac gccgcagtcc gaccgtatgg gctacaggct caaaggagaa ccgctcgaac 443281 tgaaggcccc gcttgagatg gtgtcggaag cggtttcatt cggaacagtt caggtgccgc 443341 ctgacggcaa cccgattatc ctgcttgcag accggcagac gactggcggc tatccgagga 443401 tcgcgcacat catatccgct gatcttccga ttgtttccca aatcatgccg ggcgagcacg 443461 ttcagtttga gcctgtgtcc ctccaggagg cagaagcgct tgcggtagaa cgggaacagc 443521 atataaaaga actgaaaacg agaatgaaga tggaatggct gacatagcaa aggggatgaa 443581 tgatgcagaa taaaaataaa accgtagtca aatctatggc gctgcttaat ttgtttttgc 443641 ataaaccaag cctaacctta agtgaactgg tgtcgctgac gggaatgccg aagacctctg 443701 ttcaccggat ggtcagctcc ttggaggaaa tggggttcct cagtcgggat gcgtccggcg 443761 cttattcgct gggattggtg tttttggaat tcggacagct tgtcgctgac aggctggata 443821 tcagaaaaat agcgaaaccg gtgatggaag agctgtgccg ggaagtggat gaggccgtgc 443881 agttgatcat gagggacggc aatgaagcga tatacgttga gaaaatagaa gggacacaga 443941 ctgtgcggct gtatacggcg atcggcaggc gttcccccct atacgcggga gcgtgcgcca 444001 gaagcattct gtcctttctt ccccgtgaag aaatcgaagc atacatcaaa caaaccgagc 444061 tcatttcgat tggctccgga acgattaccg atcccgaaaa actgcttcag gagattgatg 444121 cctctgtgca aaatggctat actgtcagct attcagagct cgaaaactat acggcggcga 444181 tcggcgcccc gatctttaac catgagcgcc aggtggcagc cggcattagc attgcaggct 444241 ttgaagcgag atttacagaa gacaggctgc cctatttaac agaaaaggtg aaggacgccg 444301 ctttacagat ttcaagaaaa ataggatata cataagtagc caatcttttc tctgctgcgt 444361 acattaacgt atcgacgttc aagagtggag gaaagaacat ggtgcttcga tatacagctc 444421 tgggcgattc cttgacgaca gggagaggct ccgggctgtt ttcacccggc ttcgtccagc 444481 gttttgggga catgatggaa gctgacttga aaacaagaac ggcaataaac atatttgcca 444541 gatcaggtct gaatacagaa gagattttgg gactcctgtc atatccctat gtgcaaaaat 444601 gtattcgaga tgctgatatg ataacgatca cagggtgcgg aaacgatctc atcgattcgg 444661 tcttagccta ccaaacctct aaggatgaaa cgattttcag ccgtgtatcc gcccattgcc 444721 atgagaattt tgaaaagatg attgccaaag tcgccgagat taaaggagaa aatccttccc 444781 cgtacgccat tcgtgtgttc aacttataca atccgtttcc cgaaattgat atcgccggca 444841 aatggatcac ttcgtttaat tcacatttag aaacacttgc atcagcaccc catgtcaaaa 444901 tcgcggatgc ctatagcatc ttcaaaggca aagaacagga atatctgtcc tttgacggtg 444961 tccatccgaa cagcaaaggc tatcaagcga tggctgaagc cgttcacaag ctaggctata 445021 aagaattatc agtttcatag aaaacgcgcc tcatgacagg cgcgtttttt atgtgtgatc 445081 gaaatattaa aagaaactta aaattctctg tcttctgttc tacagacaaa caaagtgcgc 445141 tagaataatg gagggcgtag gcaaatatag ccataacgtt caatatttcg tatataagga 445201 aggatggtcc ttttgtttcg gatttttaaa atgtcttttg cggttatcat tattatactg 445261 gcgcttattg cttttaacta tacggaacac acctctgtaa tccaatcggt catgctcgtc 445321 tttcttggtg cggtcatgtt tatgcagggg cttgaagagc gcaaaaaaga aaatgacggc 445381 tcaggcgctt ttaatattta taccgccgtt tttgtatggt ctgtctccct tatcggtttt 445441 acacttcata ttatataaat ctattacaca tcctgaaaat gctcgaccgt cgggaacggg 445501 gtatagaacc gatgaagcaa ggctttccac tcttgatact ctgaagaacc gcgaaagcct 445561 tccgtatggt cctcaagtgt ttcccactcc acaagaagca gatatttatg cgtttcctcc 445621 atgcattttg ataacgagtg agtgatatag cccttcatgc cggaaataat cggcgcagct 445681 tgccggaatg catcctcaaa ctcttgttca aggccttctt taatgtgaag cattgctgcc 445741 tctctgacca tgctatccct tctttctgtc ttttcaaata gtctacagca aacgatagga 445801 gatttctgca aaatcggtga acttttcctt cattttcaaa aaaatcttgc acgcaccaat 445861 tcaattaaga gaaaataaca agtggaaggc aggggaaagt catgttaaaa aagtgtattc 445921 tactagtatt tctatgcgtc ggattgattg ggttaatcgg atgctccaaa acagattcac 445981 cagaggatcg catggaagca ttcgtgaaac agtggaacga tcagcaattc gatgacatgt 446041 atcaaagcct gactaaagat gtcaaaaaag aaatctccaa aaaagatttc gtcaacaggt 446101 ataaagccat ctatgagcag gccggcgtaa aaaatttgaa agtcactgcg ggagaagtag 446161 ataaggacga tcaagacaac aagacgatga aacatatccc gtataaagtc agcatgaaca 446221 caaatgccgg caaagtcagc ttcaagaata ctgctgtgct gaaattagaa aaaacagatg 446281 acgaggagtc atggaatata gattgggacc catcgtttat tttcaagcag ctggctgacg 446341 acaaaaccgt gcaaattatg agcattgaac cgaaacgagg ccaaatttac gataaaaatg 446401 gaaaaggctt agccgtcaat acagatgttc cggaaattgg aattgttccc ggagagcttg 446461 gcgataaaaa agagaaagtc ataaaagaac tcgccaaaaa acttgatttg actgaagacg 446521 acatcaagaa aaagctggat caaggctggg taaaagacga ttcgtttgtg ccgctcaaaa 446581 aggtcaagcc tgaccaggag aaattagttt ctgaagcgac gtcattacaa ggcgtaacaa 446641 gaacgaatgt cagctcccgc tactatccgt atggcgaaaa gacagcccat ttgacaggct 446701 atgtccgcgc cattacagcg gaagaactga agaaaaagaa agaaggaacg tacagcgata 446761 cgtctaacat cggtatcgcc ggacttgaaa atgtgtatga agacaagcta agaggcacaa 446821 ctggctggaa aatctacgtg ccgcaaaccg gggaagtcat cgctgaaaag aaagcaaagg 446881 acggcgagga tcttcacctc acaattgata tcaaaacgca aatgaagctg tatgatgaac 446941 tgaaggatga cagcggggcg gcagtcgcgc tgcagccgaa gacaggcgaa acactcgccc 447001 ttgtcagcgc gccttcctac gatccaaacg gatttatttt cggctggagc gataaggaat 447061 ggaaaaagct aaacaaagat aaaaacaatc cgttttcagc gaaattcaat aagacatacg 447121 cgccaggttc taccattaaa ccgattgcgg ctgctattgg aatcaaaaac ggcaccctta 447181 aagccgatga gaagaaaaca atcaaaggca aggagtggca aaaagattca agctggggcg 447241 gctattcagt gacacgtgtg tctgagagac ttcaacaagt cgatttggaa aacgccctta 447301 ttacgtcaga caatatttat tttgcccaga atgcgcttga tatgggagcg gacaccttta 447361 caaaaggctt gaagacattc ggtttttcag aggacgttcc gtacgaattc ccgatccaga 447421 aatcgtctat tgcaaatgac aagcttgatt cagacatttt gcttgcggat acaggctacg 447481 gacaagggca aatgcaaatg tctccgcttc acttggcaac tgcttacacg ccatttgttg 447541 acaatggaga ccttgtcaaa ccgacgctga tcaaaaaaga ttcacaaaca gctgatgttt 447601 ggcacaagca agtggtcacg aaggaaggag cggcagacat tacaaaaggt ctgaaaggcg 447661 ttgtggaaga tgagcgcgga tcagcgtatc agcctgtcgt gaaaggaatc acagtggctg 447721 gaaaaacagg aacagccgag ctgaaaacat caaaagatga taaagacggc acggaaaatg 447781 gctggtttgt cggctacgat tacgaaaaca aagacctgct tgtcgccatg atgatccaaa 447841 atgtgcagga ccgcggcggc agccactatg tcgttgagaa agcgaaaaag caatttcaat 447901 cgaattaaaa tgtcttttta aaaggagcga aaggaaaaag gggatctgag gccgaatgaa 447961 ctagtaaggg ggcaaaaccc ggtttataca aagaaaagag ggattttgca tgcagcgtat 448021 tcaattggcg gaggatcttc aattttcaag agtcatacac gggctttggc ggctgaatga 448081 atggaactat tcagatgctg aacttctaag cctcattgaa tggtgtatcg atcacggcat 448141 cacgaccttt gatcatgcgg atatttatgg aggctatacg tgcgaaaagc tgtttggaaa 448201 cgcccttgcc ctttcgcctg gattaagaga aaacatagag ttggtcacaa aatgcggtat 448261 cgttcttgaa tcgcctgaac ggcccgctca cagatcgcat cattataaca caagcaaatc 448321 gcatattttg gcatccgttg agcaatcgct tatgaacctt aggacggatt atatcgatat 448381 gcttttgatt cacagaccgg acccgctcat ggatccggag ggggtagcag aggcgtttca 448441 ggccttgaaa tgctctggca aggtcaggta ctttggcgtt tcaaatttta aagatcacca 448501 gtatcggatg ctggaatcat atttgcctga gaagctcgta accaaccaga ttgagctttc 448561 cgcatacgaa ttagaaaata tgctcgacgg cactttgaac ctgtgccagg aaaaacggat 448621 tccgccgatg gcttggtcgc ctctggcagg cggcaaagta ttcactgaaa acacggataa 448681 agaccgacgt gtccgtacgg cgcttgaatc cgtccaaggg gaaatcggcg ccgcttcatt 448741 ggacgaggtg atgtacgcat ggctgtatac gcatccggcc ggcatcatgc cgattgtcgg 448801 aagcggaaag cgcgagcgga tttccgccgc gataaatgcg ttgtcataca agcttgacca 448861 ggatcaatgg ttccgcattt ttacagccgt acagggttac gatattccat aaaaagcatc 448921 agtttaccag ctgatgcttt ttcaatattg tcacaccgct tagtgccaaa ttaccattta 448981 taagtgattg attctttctt gaaagcgttt tatattaaaa ggaaacctct ctatatcctc 449041 tactgcatct ccttgcgact tcatccgcac atcaagattg gctaggaggt cttttttatg 449101 tatatgactg ccagagaaca aaagctgtta aagcacttat tattacaaaa cagatatata 449161 accgtaactg agcttgctga gctgatgcaa gtcagcacga gaaccattca cagggaactc 449221 aaatcaatta aaccgctgat ggaaaccgtg gggcttacgt tagataaaca gcccggtaaa 449281 gggttgaaag cagtgggaag tcccgagggt aaacaaaagc tgcttactga tttatcatat 449341 gaacagcatg aatacagcgc cgacgaacgg aaactgctca ttctttgttc gttattagag 449401 tctcaggagc ccgtcaaact gtacacgctt gctcatgatc tccaggtgac gaatgccacg 449461 gtcagctatg acttagatga gctcgagaag tggatttctc cctttggact gacactgatc 449521 cgcaaaagag gttttggcat ccagctcata gggccggaga atgcgaaacg gaaaattgtc 449581 ggcaacttga ttgtgaaccg tctcgacatc caaatgtttt tggaagcggt tgaattaaac 449641 atcaaaggaa aaaccgattc ttcagagaaa atgttcgggg ttgtcagcaa aggtgagctg 449701 ttaaaaatgg agcgcatctt atttcagctc aaagaaaaaa tcgctttttc attgtccgac 449761 agctcctata tagcgctcgt cgtccatctg acgtatgcga tcgaacgaat taagcttggg 449821 gaaactatca ccatggagca aaatgagctt gaggaactga tgaatgcgaa ggaatacagc 449881 tccgctcttg aaatcgcggg cgagcttgaa cgtgccttcg gcgtgacgat tccagaggcg 449941 gaggtcggct atattacaat ccatcttcga agcgccaatc gaaaatacaa aacagaatac 450001 aaagcgcagg aaattgagct ggaaacagcc ctgcaaacaa agcggctcat tgcttttatt 450061 tcagacaaaa tcagaatgga tctgacgaaa aactactctt tatatgaagg cttgattgcc 450121 catttggagc cggccgtcag ccgcataaaa gaaaatattg agatatacaa tccgatgaag 450181 gaacagatca agcgcgatta ttttctgctt tatatggcga tcgaagaagg tgtcgaaaag 450241 tattttccgg gcatgtcctt ttctgatgat gaaatcgctt ttatcgttct tcactttggc 450301 tcggctcttg aaatcaaaaa agaagaagca aaagtgaaag cgcttgtcgt ctgctcaagc 450361 gggatcggct cctcgaaaat gcttgcctcc agactgaaaa aagagctgcc ggaaattgaa 450421 tcgtttgata tgtcatctct gatcgagcta aaggggaagg atgttcaagc ctatgatatg 450481 attgtgtcca ctgtaccgat tccttatgaa aacattgatt acatcatggt cagcccacta 450541 ttaaatgagg aagacgcaaa ccaggtcaag cagtatatca agcggaagat tccccttatt 450601 cttaacaaaa aaagaagctc gaaggaagag gcgcagcaag ctgatgtacc tgacatgctg 450661 gaggcggcgg aaagcatagg gcggtatatg gaagttatcc aagatgttct gcgccatttt 450721 acgctagctc aactcaaaac aaacccggac catagcatgc ttctgctaga gctttttcaa 450781 cagctgaaga aggatggcct gatccgtgat ccggaaaaag ccgcggtttg cctggctgag 450841 cgggagaaac aagggggatt gggaatcccc ggaacaaaca tggcgcttta tcatctcaaa 450901 aatgatgaaa tcgtcctgcc ttttttcaaa atgtttgatc tcagcacccc ctatgaagtg 450961 gatggcatgg acggaaatac cctcaggatg acacgcattc tcgtcatgat ggcgcctggc 451021 tcattatctg ctgaaggctc ggagatttta agcgcgatca gctcggcaat tatcgagagc 451081 ggagaaagca tggcggggtt tcaggaagaa ggaggacaag aattgtatca gcggttaaac 451141 cgcatatttt tcacatggat gaaagaaaaa aacatactgt aaacctgcat ggcacacgtc 451201 aaaaatttgg cgtgtgtttt tctgtggatg gggaacaaaa taagaaaatg tgggactatt 451261 ttatcattca gtattggaat aattccaaaa tgaaatagtt ttacaagtta tcttttttgg 451321 gttaaaatgg gtgaggtaag gaagaaaatc taacaaatta ttgaagattc aagagaatat 451381 aggagatgac gatatggaaa cattacagca tctgattctg catgacatgc cgaatagcga 451441 agaaatagag gctgtaaaaa gcggagacca tacactgaca tataaaggtt accgtaaacg 451501 gattaatcag ctggcgaatg ccatgcttca aaaaggaatt caaaagggcg accgtgttgc 451561 attgctttgc aaaaacggcc atcccgcctc aactgttatg ttcgccgcac ttgaaatagg 451621 tgctgttgtc gtacctgtca gctggcagct gaaaccatat gaaatgacag gcattttaaa 451681 agcaagtgaa ccaaaagcga tgttttacgg agcggagttt aaagagatac tggatgaagt 451741 tcttcctgaa ttgtcctcac tgtgtgtaac aatggaaaca ggaacagctt acgaaacatc 451801 tgctgaattt gaagcgctgt ttgcaggtcc tgatcatttg ccagagacgg aaatggtttc 451861 acctgatgat acagcacttc tgatgtttac atctggaaca acgggaaacc cgaaaagatg 451921 catgattaca catggcggca tatacagata cgttaaaaaa tccaacagct caatagcacg 451981 tatgaagggc cttcgttttc tcgcgtgcca tccgatttat catacgagtg cgctcatttg 452041 catcatgctt ggaacgtttg cagaaacaac atttgtgttt acaaaggatc aagatcctgt 452101 tcacatgctg aaggtcattg aagaagagaa gattcagacc gtgatggctc ttcctgtgtt 452161 ctacacgtat ttgcttgagg cgtgggaaaa gcaccaaact gacttatctt cgcttgttat 452221 tttaatgaca ggcggaacaa aagtgccgag cagcctaata agccgctatc ttgatattgg 452281 cattccgctt gcgcatggct atggaagtac tgaggcttgg ggcatcagca catggacgcc 452341 tgatatggga atggataaag cggcatctgc aggaaaacct gtggcaggtg ttaaagtcaa 452401 agtggaagat cctctgaccg gagaagaact tcctcaagga gaaatcggcg aaatcgttgt 452461 tcatactcca ttcttattta aaggctatga agacaatcct gaagcaacag cgaaagtgct 452521 gcaaaatgga tggtttagaa ccggagattc aggatatgta gatgaagatg gctttatttt 452581 catcacggga cgctacaagg atgtcattat ttacggaggc gataacgtct atcctgatca 452641 ggttgaagaa gttatccagc agatcccggg aatccttgaa acggctgtgg tcggtattcc 452701 tgacccgctt tacggtgaaa aaccgaaagc ttttatcgtg aaaaatggcg gccagcgcat 452761 cacggaagag gatgtcatcg cattttgtaa agaacgcctg tccgcttaca aaatacctga 452821 agttgaattt gttaacgaac tgccgaaaaa caaccttggc aaggtgaaaa aagacgtcct 452881 gcgcaatcag gctgtacatt cataaaagaa gaagcccgtc cactttatgt ggcgggcttc 452941 tttgcagttg cacagacgga aagctcaggc ttaatgttct taaattgtat atcaatgtct 453001 tcgaagccgg ctgctttaaa gtcagcaatc atctgtcttc caaatgattt ggttttctca 453061 ggactggcat ccgcttcccg cggctgcatc gtaatggctg ctttgccgcc tggctttaat 453121 gcccgataaa tctgttttat gccttttgtt tggtcattcc aaatggtgta gttgttaacg 453181 gaaatcactt tatcataaaa cgaggcgggg agaggaaatg tctcgatgct tccttgtatc 453241 aggcgtacgc cctttggttt cactctgcgg gcggccagct tcagcatggc ctctgataca 453301 tcaatcccat gaagatgaac atccttctcg cgtttcagca tctgctgcat gcagtatccc 453361 gggccaaacc cgacttctaa aatgctgtcc ccgcgcgtga tacccagctg attgattgtc 453421 cactgattca gtgtttgatt ttcagcagcc atgatgtacc cggcaatcat gccgatgacg 453481 ccctttggcc tgctgaatct tctagaaagc atgttaatca ttcagcaacc aacccccttt 453541 ttgagttaat ttcctctcag cgttccatgt gaaacatttt tctgataaag caatgcgaag 453601 gtgccaagcc atgtttatcc aaagagtgtg tgaggtacac aacaaataga catgaaaaca 453661 aaggaggaga atcatcatgg caaattatcc aaaagaactg ccggcacaaa ctcaaagtcg 453721 ccagccggga attgaaagcg aaatgaatcc aagtccggtg tatgagtacg aggattataa 453781 aggagcagac aaattaaaag gaaaagtagc tcttattaca ggcggcgaca gcgggatcgg 453841 acgcgcggtt tccgtcgctt acgcaaagga aggcgcagac atcgccattg tgtataagga 453901 tgagcatgaa gacgctgagg agacgaagaa acgtgttgaa caagaaggcg taaaatgcct 453961 gctgattgct ggtgacgtag gtgaagagga attctgcaat gaagcggttg aaaaaacggt 454021 caaggaacta ggcggccttg acatccttgt caacaatgca ggtgaacagc acccgaagga 454081 aagcatcaaa gatattacga gcgaacagct tcaccgcaca ttcaaaacaa atttttattc 454141 tcaattttat ttgactaaaa aagcaattga ttacctgaaa ccgggcagcg ccatcatcaa 454201 tacgacatcc atcaacccgt acgtagggaa cccgacactg attgattata cagcgacaaa 454261 aggggcgatc aatgccttta caagaacaat ggcgcaggcg cttgtcaaag acggcatccg 454321 tgtaaatgca gtcgcgccgg gtccaatttg gacgccacta atcccagcta cgttccctga 454381 agaaacagtt gctcaatttg ggcaagatac gccgatgggc cgtcctggac agcctgttga 454441 gcacgtcggc tgttatgtgc ttctggcatc agatgagtcc tcttacatga caggtcagac 454501 cctgcatgtc aacggcggaa actttgtgac gacataagag ggagtgagac atatgggcat 454561 cacgaaagaa gaagtgaaca gctactatca aaaagcaggg attgtattaa cggacgagga 454621 agtagaccaa atccagctga tggattacgg cttaggaaaa gaaagaaaag tcgggctcca 454681 gctcttcgtc tacgtcaata cagaccgtta ttgttcaaag gaattggtgc tgtttccggg 454741 acagacttgc ccggaacacc gccatccacc ggtcgacggc caggaaggca agcaggagac 454801 cttccgctgc cgctacggaa aagtgtatct ttacgtagaa ggagaaaaaa cgccgcttcc 454861 aaaagttctc cctcctcagg aagacagaga acactatacg gtctggcacg aaattgagct 454921 agaaccgggc gggcaataca cgattccacc aaacacaaag cattggttcc aggccgggga 454981 agaaggtgcc gtcgtgacgg aaatgtcatc gacgagcacg gataaacatg atatctttac 455041 cgatccaaga atataaggat gggcttaaca gcccatcctt tttgtattga aaaaaacaga 455101 atcatcgcta taatgggtaa aaaaggaaag agggcgaggc aatgttcact tgcaaggtaa 455161 atgagcacat caccatccga ttattggagc cgaaggatgc ggagcggctg gccgaactca 455221 ttatccaaaa tcagcagcgg cttggcaagt ggctgttttt tgcggaaaat ccaagcagcg 455281 ctgacacgta ccgagaaaca atcattccag attggcggcg ccagtatgcc gacctgaacg 455341 gcattgaggc gggtctcctt tatgacggca gcctatgcgg catgatcagc ctgcataacc 455401 ttgatcaagt gaatcgtaag gcggaaatcg gatattggat tgccaaagaa tttgaaggga 455461 aaggcattat tacagctgcc tgccgaaaac tcattacgta tgcttttgaa gagcttgagc 455521 tgaatcgtgt ggcgatctgt gcggctgtcg gaaacgaaaa aagcagagcg gttccggagc 455581 ggatcgggtt tctagaggaa ggaaaggcac gggatggctt atacgtaaac ggcatgcatc 455641 acgacctcgt ctactacagt ctgttaaagc gtgaatggga aggcgaaaaa taaagagcac 455701 actttcttgt ttaaatcttc cccggatgtg gaaaagtaac agcggagacg ttaaaaagga 455761 gtgattcgag atgaatcagc aagacattaa acaaaaagtg cttgatgttc tagatcacca 455821 taaagtaggt tcgctcgcaa cagttcaaaa gggcaaaccg cattcccgct acatgacttt 455881 tttccatgac gggctgacga tttacacacc gacaagcaag gaaactcata aagcggaaga 455941 aattgagaac aaccccaatg tccacatttt attaggctat gattgtgaag gttttggcga 456001 cgcatatgtc gaagttgccg gaaaagcaaa gatcaacaat tcggcagaac tcaaggacaa 456061 aatatggagt tccaaattag agcgctggtt tgacggcaag gatgatccga atctggtgat 456121 tcttgaaatt gaaccggagg atatcagatt aatgaatgcc ggggagaaaa caccggtctc 456181 actcgaacta taaaaaattt gtgttttcag gggcgatatg ttattatgaa tagctagtaa 456241 gaaaaataag caaataaaaa agaaagtaaa cttctttttt ctgttttgag agagaagctt 456301 accgcttccc aagcagcata accagctgcc cttattcttt tccttcataa caaatcgccc 456361 ctaacgatga gatggaaaaa agactttttt gttttacaat tcacaccggc gcggcttcgg 456421 agccgcagtg acgattgaga ggtagggctt tcgttgtctt gtgttcaaga aatttccatg 456481 gtgtttactt tccagaatga ttcttcggaa caatgcttta tgaatctaac ccgcctgact 456541 tggcggatga tataatcttt atttgcgtat agaaaagaat aagacaaacc gcccggcgta 456601 cgccggacgg tttttttatt gcaaaaaaca catcgtactg aaacctcctt gtcttctttc 456661 cagtcttatc tctaggatga aattggagga agaataacgt gcatgtcatt acaacacaag 456721 tactttttat tttttgtttt ttattgctga ttcactcgat agaaacctta gcctatgcga 456781 caaggctttc cggagctcgc gttggattta ttgcgtccgc gctttctctg tttaatgtca 456841 tggtcatcgt atccagaatg tcgaatatgg tgcagcagcc ctttactggg catttaattg 456901 atgatgctgg aaaaaacgca ctggcgattg taggggagca gttccgcttt ttaattttcg 456961 gatcgacagt cggcaccatt ttgggcatta tcctgctccc gtcttttgtc gctctttttt 457021 cacgggcgat tattcacttg gcgggcggcg gcggctccgt ttttcaagta ttccgaaagg 457081 gattctcgaa acaaggattc aaaaatgccc tttcctattt gcgtctgccg tccatttcat 457141 atgtaaaagg atttcatatg cgcttgattc cgaagcgttt gtttgtcatc aacatgctga 457201 tcacatcgat ttatacgatt ggtgtgcttt cggctttata cgcaggcctt ttggcgccgg 457261 agcgcagcac gacagccgtc atggcttcgg gtttgatcaa cggaattgca acgatgctgc 457321 tggctatttt tgttgatcct aaggtatccg ttcttgctga tgatgtggca aaaggaaaac 457381 gaagctatat ctatttaaaa tggacctctg tcacaatggt cacatcaagg gtggcgggca 457441 cactcctcgc ccagctcatg tttattcccg gggcctacta tatcgcgtgg ctgacaaagt 457501 ggttttaata agaaaggctg gatcataaag atccagcctt tttgcgcttc cttatttata 457561 gttccttaat ccgcggtcgt acaaaaaatt tccgaatggg acgaaagcgg cgatgaagcc 457621 ggcagctgac catttcagcg gccatttgac agagaaggtt gcataagcca agacaagcaa 457681 atacaaaatg aacaacccgc cgtgaaccga accgacaatt gtcaccgcaa gcggaaggcc 457741 tgcccaatat ttaagcggca tagcgatgaa caacaggatt aagagtgaca ttccttcaat 457801 aaaacccatc gtgcgaagtc ttccgatcgg cgtgtgcagc ataaatcgcc ctccttgtgg 457861 acacgttttc attttatact ataaacaatc cgggggggca tatgacagct ttcaaaaaat 457921 gttcggaaaa cattcatttt tacatgcctt ttctagggaa ctgtacttgt catttacaaa 457981 aatacccgag ataatgtgta caaaatcaaa aaagaaggat gttgaaatga aacttgacca 458041 gattgatctg aatatcattg aggagctgaa gaaggacagc cgtttgtcga tgagggaatt 458101 aggcagaaaa attaagctgt cgcctccatc tgtaacagaa cgggtaagac agcttgaatc 458161 gtttggcatc atcaagcaat acacgctgga ggtcgaccag aaaaaactgg ggcttcccgt 458221 ttcctgcatt gtggaagcaa ccgttaaaaa cgcggattat gagcggttca aaagctatat 458281 tcaaacattg ccgaatattg aattttgcta ccggattgcg ggtgcagcct gctatatgct 458341 gaaaatcaat gccgaaagcc tcgaagcggt agaagatttc attaacaaaa catcgcccta 458401 cgcgcaaacc gtcactcacg tcattttctc agaaattgac acgaaaaacg ggcgcggtta 458461 gagagtgccg cgcgaagtct gttataataa caggatgagc gtgaaagaaa gagaagtgat 458521 caagcatgtc aaaaacagtt gtattagctg aaaaaccttc agtcggccgg gatttagccc 458581 gggtactgaa gtgccataaa aaaggaaacg gttatctcga aggcgatcaa tatattgtga 458641 cttgggcttt aggccatttg gtgacgcttg ctgatccgga aggctacgga aaagaatttc 458701 aatcatggcg cctagaggat ctgccgatta tcccagaacc cttgaagctt gtggtgataa 458761 aaaaaaccgg aaagcagttc aatgcagtca aatcccagct tacccgtaaa gacgtcaatc 458821 agattgtcat cgcgactgac gcaggccggg aaggtgagct tgttgcgcgc tggatcattg 458881 agaaagcgaa tgtccgaaaa ccaatcaagc ggctgtggat ttcatctgtg acggataaag 458941 cgatcaagga aggttttcaa aagctgcgca gcggcaaaga atatgaaaac ctgtaccatt 459001 ctgccgtcgc cagagcggaa gcggattgga ttgtggggat caacgccacc cgtgcactta 459061 ccacaaaatt caatgcccag ctctcatgcg ggcgtgtgca gactccgacg cttgccatga 459121 ttgcaaagcg cgaggcagac attcaggcgt ttacgcccgt tccgtattac ggcatacgtg 459181 ctgcagtcga cggcatgacg ctgacgtggc aggataagaa atcaaagcag acgagaacgt 459241 tcaatcaaga tgtaacaagc cgtttgctaa aaaatctcca aggaaagcaa gcggtcgtag 459301 ctgagctgaa aaaaacagcg aaaaaaagct ttgcgcctgc gctttatgat ttaacggagc 459361 tccagcgtga cgcccacaag cgcttcggtt tttctgccaa agaaacgctt tctgtcctgc 459421 agaagctata tgagcagcat aagctcgtca catatccgcg gacggactct agatttttat 459481 ccagtgacat cgtcccgacg ttaaaagacc gtctggaagg catggaagta aaaccgtatg 459541 cccaatatgt cagccaaatt aaaaaacgcg gcattaaatc tcataaagga tatgtcaatg 459601 acgcgaaggt gtcagaccac cacgcgatta tcccgaccga agagccgctc gttctcagca 459661 gtctgagtga taaagaacga aagctgtatg acctgattgc gaaacgtttc ctggctgtat 459721 taatgcctgc attcgaatat gaggaaacaa aggtcatcgc agaaatcggc ggagaaacct 459781 ttacggcgaa aggcaaaacc gtgcagtcgc aagggtggaa agccgtttat gatatggcgg 459841 aagaggatga tgagcaggag gatgacagag atcagacact tcctgcgctt caaaaaggcg 459901 acacacttgc cgtccgcacg ttaacggaaa caagcggcca aacgaagccg cctgcccgct 459961 ttaatgaagg gaccttgctg tcagcgatgg aaaacccaag cgcgtttatg cagggagaag 460021 aaaaaggcct cgtcaaaacg cttggagaaa caggcggcct cggcacggtg gcaacgcgtg 460081 ccgacattat tgaaaaactg ttcaacagct ttttaatcga gaaaaaaggc caagatattt 460141 ttatcacatc taaaggaaaa cagctcctgc agcttgttcc ggaggatctg aaatcaccgg 460201 ccttaacagc agaatgggag caaaagctgt ctgcgatcgc ggccggcaaa ttgaaatcgg 460261 ctgtttttat taaagatatg aaggcttacg ctcaccaaac ggtaaaagaa atcaaaaaca 460321 gcagccaaac cttccgacat gacaacatta cgggaacggc atgtccggaa tgcggcaaaa 460381 tgatgctgaa agtaaacggc aaacgcggga cgatgctcgt gtgccaagat cgtgaatgcg 460441 gaagcagaaa aacgattgcc cgaaaaacaa acgcacgctg cccaaattgc cataaaagaa 460501 tggagcttcg cggccaaggc gagggccaaa cctttgcgtg tgtgtgcggt caccgtgaaa 460561 agctctctgt atttgaaaaa cgaaaaaaca aagacaaagc gcgtgctacc aaacgggacg 460621 tatcctctta tatgaaaaaa caaaataaag atgagccgat taacaacgcg ctggcagaac 460681 agctgaaaaa actcggtttg gataaataat aaaaaaacct gtgcctatcg cacaggtttt 460741 ttattggact taggtcctgt tttcttaatg ttcaaaaagg gaaaaaaaag ctagcaatct 460801 gcattttttt tcttttatag taaatgtact ttgtaacatg gcagtcatat tttcgtctat 460861 aactatttgt gagcgtctga tttgcttcag gcgacaaagg gggatttgcc tgtgaggcat 460921 gtactaattg ctgtcatctt attcttctta tctatcggac tttccgcagg gtgtgctgaa 460981 gctggaaaca agacccaaaa tcagtcggcg acagaagtga atgccagccc gctccagccg 461041 gcggaatatt tcatctatca caatttaatg aatgacaaag ggctgatcaa aaccgatttt 461101 tcagaccagc cttcttactt gtcggaatct ctcggactgt ggatggagtt tctgctcagc 461161 aaaaatgacg caccacattt ccaggatcaa tatcagcatc tgactgattc atttctgatg 461221 agcaatcact tggtgacgtg gaagattcaa aatggccaag cgagcgggac gaatgcgctg 461281 atagatgata tgagaattat gctgtctctt gaccaagccg ccgcaaaatg gggccgcagc 461341 gactacgcgc aaacggctag ggatatcggc acgtctttga agacatacaa tatgaacaac 461401 gggtttttta cagactttta cgactcacag gccgcttcaa aggatgtgac gctttcatac 461461 gtcatgcctg atgccttagc tgtcttaaag aagaatggaa tcatagacga agaaacagaa 461521 cagcggaatg ccaatgttct ctattcagct cctttaaaaa atggctttct gccgaagaca 461581 tacagctcgg agacgaagga atacacatat gatagtgaaa tcaacctgat tgatcagctt 461641 tacgctgctt ggcatttgcc ggaaggggat gaaaaagcat ctgttttagc ggactggatc 461701 aagcaggaat ttcagaaaaa cggaaagctg tacgggcggt attcggcata tacgaaggag 461761 cctgccgtcc aatatgagtc tccatccgta tatgccttag ccgtattgtt tttgacaaaa 461821 cagcatgaaa acagttctgt catcaaagcc atatatgata gaatgaatga ctttgaaatt 461881 catgatccgg tgaaatcgta ttatggaggc tatatgagcg gcactcagac gcattcattt 461941 gacaatctgc tgccgctgtt agccgaaagg aagcttttta atgaaaatat cattcagtga 462001 atcacaaaaa ttatttgctt atttttcagg gctcatcgcg gccctgtctt tgtttattta 462061 ttatgtgtca gcccagcaat cagaaggtgc tctgatcctt tgcatcacat ttggcgtcat 462121 cgccgcaggc atctggttcg gcccgattta cgcgctggca gtgaccttaa tcgtactctt 462181 tgttctcggc accttaatga tgtttttcca gactggacag acatcgctct ttccggctga 462241 ggaagggctg cgaatgcttg tcgtgtgggg aatcgcgctt ttgctgtttt cttttatttc 462301 tggaagaatc cacgatatta cagcagagct tcggcgctca atgacacggc ttcaatccga 462361 aattaaaagc tatgttgctg ttgacagagt gactggtttt gataacaagc aaaggatgaa 462421 gctggaactt tcagaagaaa tcaagcgggc ggagcgctac ggcaattctt ttgtgttttt 462481 gctgctccat atgcattatt tcaaagagtt taagtctttg tacggtgaaa aagaaacgga 462541 ccgcctcttc caatatgtcg gtcagcaaat caggacaagc gttcgggaaa cggataagaa 462601 attccgtccc tctgacgagc gtatcgggat cgtgctgacg cacacgcctg ctgaacatat 462661 gccggccgtt ctgactaagc tgaagaaaca attggataca tatcagctgg aaaatggaaa 462721 gtatgtgtcg cttacgttcc acgtttgcta tttgccctac cgcaacgata tccaaacagc 462781 tgatcaattt ttagaagaac tggaaaacga gatgatgatg aatgaactat aaaggaatca 462841 cattgctatg cgtcatgatg cttctatttt cagctattgc gtcttttccc gtttctgcgc 462901 aagcgaaaga tcaggatgcc ggcattctca tcatctactc aaccttggac ggcaaagagt 462961 cgtcacaagt caaaatgctc gatttgcttg cgggccactt tacatcccat gtgacagtca 463021 aaaaagattc agacgttgaa gcgtcggatt tcaaagggaa agaccatgtg atttattacg 463081 gccaaacgaa aagaaagctc agccaaaaat tgctgtctct tatcagcggc gtgaaaaaac 463141 cggttgtcgc cattggctat aacgcaggcc aaatcagcca attttctggg ctttcattag 463201 cccgcaaaga aaatgtgttt caggttcaca gcaggtcaga aaaggccgat gtgtctctgg 463261 aaagcgggct taacgtgctg agtgtatcag gcctgaaagg aacggcgctt tacaccttca 463321 aagcggatga aggcacaacg cattctttta tatggaaaac aaaaaaaggg aatgtgtaca 463381 ttggattaac aaatttgtta aatgacaatt tgatcgtggc gaaacagctc agagaagctt 463441 tcggagagaa ggcggggacg acgttattgt atttgcgtct cgaggatatc agcccgatgt 463501 ctgatgaaaa actgctgctt caagccggta catacctgca taagcggcat attcctttta 463561 tcctggcggt cattccggtt tacttgaatc cggaaacagg cgacaaagtg tatttgtcta 463621 atcaaccgaa gatggtcaag gtgctgaaga agctgcaaag catgggcggc agtatcatag 463681 ttcacggcta tactcacgct tatcgctaca gtgaaacagg agagggattt gaattttggg 463741 atgcaaaggc ggatcagccg attacatccg gaaatgccga agaccccccg tccattttgg 463801 agaaagaaca ggacttcccg aacgaacaag cctatcacag ctatcttgaa ccatttcggg 463861 aaaaggaaga aacgtataca aaacaaaaac tgacgcgtgc cattgaggat ttgacatcat 463921 cgggtcttta cccgctggcg tttgaagcgc cgcattacac gatgtccgaa tatggctatc 463981 aaatcgcctc gcagtatttt acaagcattt tcggccaggt ccagctcagc agcacaacat 464041 ggaaaacatc cggtgcacct ccgtttgtga ctgctccttc gatgctgcac ggaatgacgc 464101 tttatccgga aacgatcggc tttgtcgaca catcgaagca aaacccgctc ggtgagatgg 464161 aggagcatat ctcccagatg attgattttg aaggcggagt agccggagga ttttatcacc 464221 cgtaccttgg gatgaaatat ctgcctgagc tggttgatca gatggaacgc attccagaca 464281 gtgaatggct tgatttaaag aaaacgaaac aaaccgtcaa aacagacaaa gtggaaattc 464341 atacaagcgg tgacggaacg attcaggtga aaaacggcgt aagccccatt tacgagtttt 464401 tcgatcatca ccggcaaacc cctctggaaa aggcgttatg gattctctcc gctgttgtgc 464461 tcttatttgt catcatgttt gtcagttata cgttttactt gagagccaca ttgaaaaaac 464521 gaatttttaa ggagagaaga agccttgggt aatacgctgt tctttatctc gctaagttta 464581 atatgggtta tgcttctcta ccacatgttc ctcatgcagg gcgggtttcg ccactatatg 464641 accttcgaac ggaatatccc gaagtggaga gaaaatatga aggaactgcc gaaggtcagc 464701 gtcctcatcc cggcgcataa cgaagaggtt gtgattcggc agacgctgaa ggccatggtc 464761 aacctttatt atccgaagga ccggctggag attatcgtcg ttaatgataa ttcatcagac 464821 cggacgggtg atatcgtcaa tgaattttcc gagaaatacg atttcatcaa aatggtgatt 464881 acgaagccgc caaatgcagg aaaaggaaaa tcctctgcac ttaactcggg ttttgccgaa 464941 tcgaacggcg atgtgatctg tgtgtatgac gccgacaaca cgcctgagaa aatggccgtg 465001 tattacctcg tgctcggcct gatgaatgac gaaaaggcag gcgccgtggt agggaaattc 465061 cgcgtcatca atgcggcaaa gacgctgctg acgaggttta ttaatatcga aacgatctgt 465121 tttcagtgga tggcccaggg aggcagatgg aagtggttca aaatcgccac gatcccaggc 465181 accaacttcg cgatccgcag aagcattatc gaaaagctcg gaggctggga tgacaaagcg 465241 ctcgctgagg atactgagct gaccatccgg gtatataatc tcggctatca catccgcttt 465301 ttccctgccg ccatcacgtg ggagcaggaa ccggaaacat ggaaggtatg gtggcgccag 465361 cgcacccgat gggcgcgcgg caatcaatat gtcgtgctca aatttttggc gcagtttttt 465421 aagctgaaac gaaaacggat tatctttgat ttgttttatt ttttctttac gtacttcctg 465481 tttttctttg gcgtgatcat gtcaaatgcg atttttgtag tgaatttgtt ttatgatttg 465541 catttgtctg ttggattttt ggcaatgatt ctctggattt tggcgttttt cttatttatg 465601 acagaggtca tgattacgtt gagcattgaa aaaacagaaa tgaacaagca aaactttttt 465661 atcgtatttc tcatgtactt cacatactcg caggcatgga ttgtgcttgt tatctactct 465721 ttattcgtag aaatcaagca ccgtttattc aagcaagagg tcaaatggta caagacagaa 465781 cgatacaatc aacataaaag cgggtgacct ttttgaaaca aataatgatt tttctcacaa 465841 gcttcatgct gctggcgatg actggacaaa cggctcttgc caaagacgta caggtcagcg 465901 gttcgctcct tgggaaaagc agccaagaac aagccaaaca gcaggtgctg acaagcgagc 465961 tgattacact gtatggatca aaagacagcg cagagctgac gtatcagatc ccggcaggcg 466021 cctcttcggg caatcagcaa ttggtaatcg aatacgaggc atcaaatctt ttaatttctc 466081 catcatcgtt aacggttgtc attgatgatg aaccggtcaa gacgttaaag cttgatggtg 466141 attccaaacg gaaaacagtg aagctgaatc tgaataaaag ccagtctgcg caaggctatc 466201 acaacgtatc gctgaaattc tacggcgtaa tgaaagaggg cgtgtgcgtc agacaggata 466261 catcaggcaa ctggatcaaa atttatccgg acagccggct gacacttgct gacagcagtg 466321 aagcgaaggg aacgtcgctg gaccattatc cgtatccttt cgcccaatct ggaaatacag 466381 cggaagaaac agctatcgtc attccggata acccaagttc agcagaaata gaagctgctg 466441 ttaaaacaga aggctatttg aaaacggtgg acagcagtgt cagtattgcg tatgtcacgg 466501 aatctgaact gaaaaaaatc gataagccga cgattgttat cggcgtggac aagcattgga 466561 acggcaaagt gaaaaaactg ttgaaacaag ccgggctaca ggcaaaagga gaaaaccttc 466621 tgcttgcgga gcgggtgctg aaagcagagg gcaaacagca gccggttctg tttgcgcaag 466681 cggcgtccga ggacgcgctc acaaaaaaaa tcagcgtgat gacagatcag acatatacag 466741 gccagctcag cggcgataca ctttcaatca gcaagcttca gcagactgaa aaaaaagaaa 466801 gcgataagct gacccttgag aattttggag cgggtgatat cacaattgga gccgacaaaa 466861 catcttcagc acattatttt tatccggctt cggctgtttt agatgaaaac caatcggcga 466921 agctgtcgct taaactgaaa aagtctgaaa cgattcaagc ctcaacggct gaaaacgagt 466981 cagcctctca ggctgcagaa ctgaaagtga tgatcaacgg ccagccgcac tcggtccggc 467041 ttgatgaatt aggaaaagaa gataaaaacg gattctatca tgtcacagtg aaagtggacc 467101 ctaagctgct gcaaaaaaac cgctacattg atattcagtt cgtcacgacc ggtttaaagg 467161 aaaacaaccc ttgtaacacc actgatgaag aaaagtgggt ttttatcgat aaaaacagta 467221 cattatcata cgccatcaaa ggcatgtccc cgtcagcgga ttttcaagag tggccgctgc 467281 cttacgccgg aaaccaggat caaacaacgt taatcgtgct tcctgacacc gtaagccaat 467341 cgaagctaga ggagctttct ctcgtaacag aatcctttgg caacgaagca cagcattcat 467401 atacggtaaa gaaatcatct gacgttacag caaatgatgc gaaaggacga aacctcattt 467461 tcataggagg gatcaatcaa ttttctcttc tgaaggagaa atcatcagat ctgcttgtgc 467521 cgcaggaaaa gaacggctcg tttgatgtat ctagtttcga gatgctgaat gagacgacaa 467581 aacaagtggt atttacccaa gcatcggttt gggattcacg ctatacaatg gctgtctttg 467641 caccgtcaaa aggagatggc acggctgtca caaaagagat catcagttat ctgaacagca 467701 acgatgagtc ggcaaccgtc cttaatgaaa caaacagcca gcaggtgttt acaaaccacc 467761 agcagctcaa atcggaaaca aacagttccg atgcagaaca accaacacag gatcatagcc 467821 agaaatggat gtatattggt gtgctggcac tcattatggt ggttgcggca gtgttcattt 467881 ggattgccgt aagacgcaaa aaaagaaaga cagatacaga ataaaacaga ggcgatttta 467941 gcctctgttt ttttattttt ggtaagtaaa ttccatttgt ggaacctgtc attttatttt 468001 tttctctcag ccaataagcc tctttacaac gtgcgggaac gggagtatga tctcttttag 468061 aaaacaaatc gcttaatctg aaatcagagc gggggaccca atagaacggc tttttgccgt 468121 tggggtgaat cctttttagg tagggctaac tctcatatgc ccgaatccgt cagctaacct 468181 cgtaagcgtt cgtgagagga gatgaatgaa acctgtgttc gatgttatgg cacaggggca 468241 tccgtttgcc tctgtgtttt ttgttgttca tttttgaatg caaatcgcat acagagacat 468301 catagcagaa aggactatca tcaacatgtg agagcaagac actgatggat gttttattgt 468361 tttaattgaa aaatgagaaa ttaaaagggg aagacatcga tgtatcattc aatcaaacgt 468421 tttttgattg ggaaaccact aaaatcccaa gcagctggag agcaaaaact gacgaaatta 468481 aaagccttgg ctatgctttc ctcagatgcg ctgtcatctg tcgcatatgg gacagaacaa 468541 attctaatca ttttggcaac aatcagtgca gccgcatttt ggtactccat tccgattgcg 468601 gttggcgttc tcatcttgct gctcgcactg attctttcat acaggcaaat tatttacgct 468661 tatccgcagg gcggcggggc gtatatcgtt tctaaagaaa atctcggtga aaaaccggga 468721 ttgattgcgg gcggttcatt gcttgttgat tatattttaa cagtagcggt aagtatttcc 468781 gcaggcacgg atgccatcac gtcagccttt cctgcattgc atgattatca tgtgccgatc 468841 gctatttttc tcgtgttagt gattatgatt ttgaacctgc gcgggctttc ggaatcagca 468901 tccatacttg cctacccggt ttatctgttt gtggtggcgc ttttggttct cattgcagtc 468961 gggttgttta aacttatgac aggacaaata gaccagccag cccatcatac atcgctcggc 469021 acacctgtag ccggcattac gctatttttg ctgcttaagg ctttttcctc cggatgctca 469081 gcgttgaccg gggttgaggc catttctaat gcgattcctg cattcaaaaa cccgcctgcg 469141 cgaaacgcgg caagaacgct tgcgatgatg gggattttgc tggcgattct gttttccggc 469201 atcacggttc tcgcgtacgg gtatggtacg gcgccgaaac ctgatgaaac agtggtttca 469261 caaattgcgt ccgaaacctt tgggcggaat gtgttctact atgtcatcca aggtgtcaca 469321 tcgcttattt tggttcttgc ggcaaatacg ggattctcag ccttcccgca gcttgccttc 469381 aacctggcga gagaccagta tatgccgcga atgtttacag tcaggggcga ccgcttaggc 469441 ttctcaaatg ggattatctt tttaggcttt gcctccattg ttctcattat cttattcggg 469501 ggacagacgg agcacttaat cccgttatat gctgtgggcg tatttattcc atttacgctt 469561 tcacaaaccg gcatgtgcat gaaatggatc aagcaaaaac caaaaggctg gatcggaaaa 469621 atgctgatca actcctgcgg cgctctgata tcatttatgg ttctatccat tctgtttgtg 469681 acgaagttta atgtcgtatg gcctgtgtta atctttatgc ctatcgtcgt tttgctgttt 469741 tttgcgatta aaaatcacta tactgcggtt ggtgaacagc ttcgcatcgt agacaaagag 469801 ccggaagaaa tcaaaggcac cgttgtgatt gtgcctgtgg ccggtgtcac caccgtcgtg 469861 caaaaatcga ttcactatgc gaaatcactg tccgatcagg tgatcgccgt tcacgtgtca 469921 tttgacagag aacaggaaaa gaaattcgaa aaacgttggg aagagcttaa taacggagtg 469981 cgtctcgtga cgcttcactc ctcttacaga agccttgtcc atccgtttga taagtttttg 470041 gaaacagttg aggcaaaagc gaagaaggag cagttttccg ttatggtgct gtttccgcaa 470101 tttataacga aaaaacgctg gcacaccatc cttcacaacc aatcggcctt cctcctcaga 470161 gtccggctgt tctggaaaaa ggacataatg gttgccacac tgccgtatca ttttaaaaag 470221 taaagctcta ggaccaaggg aatcaccttg gtccttttta gcgggaaaag gaggtatggg 470281 ggtgtataca caaggtgctt ttgtgatcgt attgaacgaa agtcagcaaa ttctgctggt 470341 gaaacgaaaa gatgtccctc tatgggattt gccgggcggc agggttgatc ccggggaatc 470401 ggctgaggaa gcggcagtgc gggagatatt ggaagaaacg ggatacaatg cagcgctttc 470461 tgcgaaaata ggtgtttacc aaaggccaaa gtttcaagat gaacagcatc tgtttttcgg 470521 aagcattaca ggcggacaag caatggctga cggcacagag acagcgggat taaagtgggt 470581 ttccccgggg cgtttgccgc tttttatggt gccgaatcga aaaaggcaga tcaatgattt 470641 caagaacggc gctcaagatg taaatgtcac cgtcaaggat agcgggttgc tcgcggcgat 470701 cgacctgttg aaaagaagac tgggcaagtg attcaggtct ccgggtttta aagcctttct 470761 cctgtggtat tgaaaaaagg aaaaaggagg atacgttatg gcacacaaaa ctgcaggaca 470821 agcaatgaca gagctgcttg agcaatgggg agttgatcat gtatacggca tccccggaga 470881 cagtataaat gagtttatcg aagaattaag acacgaaaga aatcaactga agttcattca 470941 aacccgccac gaagaggtag cggcactggc agccgcggct gaagcaaaac tcaccggcaa 471001 gatcggagtc tgtctgtcaa tcgcagggcc gggagcggtg cacttattaa atggtttata 471061 tgatgctaaa gccgacggcg cccctgtgct ggcgattgca ggacaggttt cttctggcga 471121 agtcggacgg gactatttcc aggagattaa gctggagcaa atgtttgagg acgtggccgt 471181 gttcaacaga gaggtacata gcgcggaatc acttccggat ctcttaaatc aggcgatcag 471241 gaccgcctac agcaaaaaag gcgttgcggt attgagcgtg tcagatgatt tgtttgcgga 471301 gaaaatcaaa cgggagcccg tgtatacttc accggtgtat attgaaggga acctagaacc 471361 gaaaaaagaa cagctcgtca cctgcgccca atatattaat aacgctaaga aaccgattat 471421 cctggcaggg cagggaatga aaaaggcgaa acgggagctc ttagaatttg cggacaaagc 471481 cgccgctccg atcgttgtta cactcccggc aaagggtgtt gttcccgata agcacccaca 471541 ttttctcggc aacctcggtc agatcggaac aaagccggct tacgaggcaa tggaggaatg 471601 tgatttatta atcatgctcg gaacgtcatt cccgtaccgt gattatttgc ctgatgacac 471661 gccggcgata cagctcgatt cagacccggc aaaaatcgga aaacggtatc cggtgacagc 471721 gggccttgtc tgtgattcgg ctctcggttt gcgcgaattg acagagtata ttgaacgcaa 471781 ggaagacaga agattcctga atgcctgcac agaacatatg cagcattggt ggaacgaaat 471841 tgaaaaagat gagacagagg caacaacacc gcttaaacct cagcaggtcg tggcccgtct 471901 tcaggaagcg gcagccgatg atgcggtgct ctctgtagat gtcggcactg tgacagtctg 471961 gatggcgcgt catttcaaaa tgaacgcgaa tcaggatttc atcgtttcca gctggcttgc 472021 gacaatgggc tgcggcctgc cgggagcgat tgcagcgagc ttgtccgaac cggaacgcca 472081 ggcgatcgcc gtctgcggtg acgggggatt ttccatggtc atgcaggacc ttccgaccgc 472141 cgttaaatat aagctcccga tcacagtcgt tattttaaac aacgaaaatc tcggcatgat 472201 tgagtacgag cagcaggtca aaggcaatat cgactatgtc acaaaacttc aaaatgtcga 472261 ctatgccgca tttgcagaaa gctgcggagc aaagggcatc aaagtgacca aagcggaaga 472321 gcttgcgccg gcttttcatg aggcgctgca ctctgaccaa ccggtcgtag tggatgtcat 472381 gattggaaac gaaccgccgc ttcctggcaa aatcacctac gggcaggcga aaggctttag 472441 caagtacatg ctgaaaaact tcttcgaaaa ccaaaaattt gaaatgccgt cactgaagaa 472501 aagtttgaaa cggttatttt aaaaaaacag gggccctaag agcccttgtt tttttttttt 472561 tttttggaaa caaatgtatt ttcagcatgt ttgaattcat aaaatgatcg gtatatgtat 472621 taggaactga tttcgccata ctcgaaacag acaaaaggac aaatgcatct tgtttcaaag 472681 gaagatgcat ttgtccttgc atgcttattc ttatcaaatc ttacagaact cttctcataa 472741 taggttattt ttcttttttc ttcagcccga agaagaaagg aaaagcagaa ccgaccaaga 472801 aggtgccgaa taaaaacatg ccgccgataa acacgtggaa atttgtgtgt ccggccgtaa 472861 acgccgtgat tagggaaatg atactgagca cgatcatggc aatgccgggc gcgactctca 472921 tttttccctt ggatttatgg gcagcaacag aacataaaat gccgataaca ataggaacaa 472981 tccacaaata aaacagaata aatactgaca tcatcaaaac tccgattttt cttctatcat 473041 aacaaatttc tgtcaaaaag ggtatcaatg agcttttgcg gaaaaataaa aaccggcttt 473101 agaagccggt ttttttatcg aaacgtatct acaattaaaa acacattcaa agcaacgatc 473161 aatacagcaa tcagccaaga caccactgtg atccatttgg cgttgatcag agatcccatg 473221 atccgtttat tgcttgtaaa cataataagc ggaatgaggg caaaggcgat cccgaaggac 473281 agcacgacct ggctcagtac gagagcggtc gtcggattaa cacctgacgc gatgatcaag 473341 atcggcggaa tgatcgtgat aaaacgccgt acatacagcg gaatgcggta gttgataaat 473401 ccttgcataa tcacgtcgcc tgaaagtgtg ccgacagacg aactggatag accggcaacg 473461 agcagcccga tcccgaacaa agccgcagac atagggctga caagatgtcc gaattgctga 473521 aatgcgacgt cgagatcctc aacaaacagg ccgtttttga agaataatgc ggcagccaca 473581 atcagcatac ttgcattaat agcccctgca atcagcatcg ctattaaaat atcaataaat 473641 tcaaacctaa agattttttt ccgttctgca tcagttttgc caaccacccg ccgctgtgta 473701 agggcagagt gtaaataaat ggcgtgcggc ataacagttg cgccaagaat acccgctgca 473761 agaagcacac tgtcggtgcc atgaaacgcc gggacaaaaa ggcccttcat cactgacacg 473821 gcatcaggct ttgcgaaaaa ggtctgcaac gcaaaggcga tcacgaccac aaacagcata 473881 ccggcaatac ctgcttcaag tgagcgataa ccacggcgct gaagctccaa tatcgcgaaa 473941 gaaccgatcg ccgcaataat agacgcttca agcatcggaa tgccgaacag caaatacagt 474001 cccagagccg ctccgataaa ttccgccaga tcagttgcga taatgaccaa ctcgccctga 474061 atccataatc cgatcgagac aggcttcggg aattcttcac gggcaacctc aggcagattt 474121 ttgcctgtcg caataccgag tttggcggat agggattgaa ttaaaagcgc catgatattg 474181 gaaaataaga tcacccataa gagcatatat ccgtatttag aacccgccga aatattcgtt 474241 gcgaagttgc cgggatcaat ataggcaatg gctgctataa atgcagggcc gagaaaaggg 474301 agcagccctc tgaatcctct gattttcccg tcaagcgcat cttggacggc tttggaacgg 474361 ggagattgtg ctgtgatgtc cttgttcatc atgtctcacc tgaattctgt ttgtttttgc 474421 cgtacaacaa agagtttcct taaggcaaat tattttatct acatcatatg accatcccgg 474481 tttcttgtca accgaaaatg ttcaaaatac acttctgaat ttttccctgt tatgtaacat 474541 gatatgtagg gattcgtgat aaggtcccat ataaaaagac atcgtttcat ttcgaaacga 474601 tgcctcctgt atctaatgag tctaggcttc cttccgcagc ccgcggaata taaggcccag 474661 caagaacacg aagatggctg ccccgatgat ggccgggaaa atagcaaagc cggcgaggct 474721 cggtccccat gtgccaagaa gtccgtgccc aatccaagcg ccgatcagcc cggcaatcat 474781 agagccgaaa attcctcccg gcagccggtt tcctacaatg gcgctcccaa ttaatccgat 474841 aacaattgca acaactaatg aaaccaaaaa gctaagcatc atgatcacct ctcataaatg 474901 atttaccaat caataaccgc tcctgatcat ttcgaaacac ttgaaagcat attcctttat 474961 gatcctgttt taatctttct ctgcacactg ccgtcagcta aatgaacaat gacctcagtg 475021 cctttatgcg ccgcgatttc ctttgcccgt tcaatcgctt ctttctttgt atccttgatt 475081 tcagacacac gtttggcgcc ctcggctttg actgcccagc cttttttatg cttaataaca 475141 tgctctgctt tattcatgag ctcggggccg ctgccgctgc ttggatcagc atcgcgttct 475201 gtctcatcat catgcgtcag gaaatcatca atttcatctg tagaggcgtt ttccgcccat 475261 tccttcgctt tgcttgtcgc aattggaatc gcgcgccctt cctcatagcc ttcatcaatc 475321 atcgcattcg caatgtctat cgcctttttt ctcaccggct tctcaagatt ttttaatgaa 475381 gcaggataat ccttcatcga ccaaggcatg tctatcactc cttttccttt tataaaaatg 475441 gtacccgcag gtgaaaaata aaaacgcatc cgaaaaaatg aaggtatact atatagtaga 475501 aaaaacggaa gggaagtgcg ggttgggtgc caacagaacg aaaagaagac ttacatcagc 475561 aattaaaaga gatagagaaa tgggaaaaag atcagcaaaa agtctggttt tgggaaaagc 475621 tcagccgtct cccgtttcaa ctcctggaca agctgacacc agaattcatc cagaaaaaga 475681 tcggcaagct cttggatgag gtcggcagct ttgttcaaac aggcggacag tacctgacat 475741 ctgaaaaaca gattatcagg atgtttcaaa agaaactgcc ggaggagatc tttgaatcgc 475801 tggaggacat ccggaaagcg cctcttcctg tcatggatga aattgcggaa ggaatgggca 475861 aaaacagaac caacgcagca accgttcaag gcgcgacaac cggtgtgggc ggcgtgttta 475921 cgctggcggc agacattccg gcagtgcttg gcttatcact aaaaacatta caggatatcg 475981 cagtcgcata cggctatgac ccaaaggaga aaaaagaacg agtcttcatt gtgaaatgcc 476041 tgcagcttac gtcggctgat gttgtcggca aaagatcgat tttgcaggaa ttaaaacact 476101 acgatcaaga ccgtacatat aagaatgtcg cttctcaaat ccaaggctgg cgagaagtcg 476161 ttttgggcta tcgagacacg tttggctgga aaaaactttt ccagatagtg ccggttgccg 476221 gaatggtttt tggcgccgct gccaatcgct caacattaaa cgacattacc gagacaggca 476281 tgatgctgta caaaaagagg cgcattcttg aacgactgaa agaaacagaa cgagagatgg 476341 aatagcagaa agcagacgga caccgcgatc cgcctgcttt ttttagtgga aacataccca 476401 atgtgttttg tttgtttaaa agaattgtga gcgggaatac aacaaccaac accaattaaa 476461 ggaggaattc aaaatggcag acaataacaa aatgagcaga gaagaagcag gtagaaaagg 476521 cggagaaaca acaagcaaga accatgacaa agaattctat caagagattg gtcaaaaagg 476581 cggagaagcc actagcaaaa accatgacaa agaattctat caggaaatcg gcgaaaaagg 476641 cggagaagcc actagcaaga accatgacaa agagttctat caagaaatcg gtgaaaaagg 476701 cggagaagcc actagcgaaa atcatgacaa agaattctat caagaaatcg gccgaaaagg 476761 cggagaggca acaagcaaaa atcatgataa agaattctac caagaaattg gctcaaaagg 476821 cggaaacgcc cgcaacaacg actaatcaaa agcataaagg cagacaacct gtaaataaaa 476881 aagcgatccg gcacatcagc tggatcgctt ttttttggaa tcttctcaat ttatgccgct 476941 attgagatac aataagtgaa aaaggggttt tcgctaatgt ccaagatgca aaacttgctc 477001 gccatcgcaa atgaagtcaa agaaaagcac gccaattttt caatctcaga ggtcaacgac 477061 cactgcgtgc gccttgcggt gtttacggga gaatatgact ggcaccatca ccctgactca 477121 gacgaattgt ttattgttct tgaaggggag ctgctgatcg attttaagga caaagaaacc 477181 gcggtgctca aagcaaatga cagcctgctg atccctaaag gcacggttca ccgcacacgc 477241 tcttacgtca gaacggtaaa tctctgtgtg gagcataaac aagccgaaac cgtcatcata 477301 gaggagcagc catgctaatc aaaaagatga tatgtgaagt agatgctgca aacgctgaag 477361 catttgcaaa agcgcagtca cagtgggaag cgttatcgca tataagcggc tttatcaaac 477421 aggccggcgg ctggcgaaaa acgatagacg agccgctcac cgcagaaatc atcagtgtat 477481 gggaaaacag agaagcctat gatcatttta tggagaacga acatgacagc atatacgagg 477541 aaaacgatca gaaggctgta attctttcga tagaggtgac ggtgtacgaa gaggataaac 477601 cgttcgttca cgatctgtta cataaccccg atatccggta cgaaccaaac tggacggttc 477661 tgaaggcata atcaaagccc aaaacatcat gttttgggct tgtctcttta ctcgcgtccc 477721 ggaagtgtat tatgaacaaa aggcggtgct ggttttaact ccggtttttc tccaaacgtt 477781 tttgcttctt tcacatattc aaaggcttct ccgtccggcg ctttttcatt cagccagttt 477841 tgctcggcgc ttacttcgcc ttcagagaaa ttgataagct gatgtgagaa ctcttgtttt 477901 tcgagcgctt tcgggaatgt acccggcaca accggacctt cctgtgcttc taattcttta 477961 atggcggcga gccattggtt ctggtgcatc gtgtcacgcg ccagcaggaa gctgagcata 478021 tctttgacgc ctttgtcatc cgtcatttca aacaggcgtg cgacctgcag acggccctga 478081 gattccgcat tcaggttggc gcggaagtct gccagcaggt ttccgcttgc tacgatataa 478141 ccgccgctcc aaggtacgcc tgtactgctt tccggcatgg cgccaagtcc tgatacaatc 478201 gcatggtgag ggttcatgcc gcctaggatg gagccgatga ccggatcttc agcagctttt 478261 tcctgctgat caagaggggc atcctcaaga agtctggcaa tcatcgttgc gatcatttca 478321 acatgcccga gctcctcagt tgccgtatcc atcagcaagt ccttgtattt ttcatttcct 478381 cttgtgttcc agccttgaaa taagtactgc atggcaactg aaatttctcc gaattgcccg 478441 cctaaaattt cttgcatttt tttagcgaat aatggatctg gacgatctgg tttagcagga 478501 tgctgcagca tttttgtgtg cttaaacatg tacccatctc ctttttcgtt tatctctttt 478561 tatatttccg atcgatagaa agataaacga aaaacagcgt atcgagatgg gaactatgaa 478621 tcttttcgca gctccaacag ttcccggatc agctcccggc caaagatggg ctcatactgc 478681 cggtaaacag ggtcaagacg cttcatccat tcttgtttct ctttatctga cagctcataa 478741 atatgtatag cagaattctt tttgatttct tccagctgct ccttgttcat ttgttcggca 478801 tacgtttcat tccactccgt tgtctccttc atcgcttcag tcaaaatgcg tcttgtttct 478861 ggtgtttgcg ccttccagaa gtgttcatca gtcatgacag cgtagccgag ataaccgtgg 478921 ctgcttattg tcaaatagtc ctgaacatta taaaattttt tagaatagat gtttgaaatt 478981 gtattttctt cgccatcgac tacattgttt tctaacagct gaaaggtaga attgaaggat 479041 tcctgatgag gtgttgcgcc aagcagcttg aactgatcct caatcacatc gctttgcata 479101 atgcgcagat cctgcccttt taagtcatcc ggtgttttga ccggcccttg atttgttgtg 479161 atttgcttaa agccgttcgt ccaataggcc aatcctttca attggttttt ctttagagaa 479221 tcaaacagct gtgtgccgat gcttccgttc agcccttttt tgacggcgtt gtaatctgta 479281 aatgcatacg gcagatccag cactccccat tcaggcgaga gcatgccgag cttcgatgtg 479341 gagggggcga taaattgaac atcgccgttt tgcaatgctt caatttcttc aatgtccgag 479401 tacaggcttc cattcggaaa tacttctatt tttatttttc cgcctgattt ttcgttcacc 479461 agatcagcga atttattggc ggccagccct tttggcgtat tttcagcaac cacgtggctg 479521 aatttaaaca cgatttgatc ctgcaggcct tcctggtcgt catcataaac aatcttttta 479581 ttgccggtat gatcatggaa tccgataaat aaagcggttg caattccagc gatcatcagt 479641 gcgagacatg caagcaaact cttcatgaaa agccctcccc tatgttaagg ataatggggg 479701 ctatgacatt cgtaaagacc tgaaaggaga agctgatgaa caaaaagaag ctctcaatcc 479761 gttggaaaat cacgatctta tcctatatac tcgtcatttt ctcctttttg atcggcggca 479821 ttgtgctcat cggcaacatt cagcatacag aggagcggga gctgaaaaag cggctgatga 479881 atacggcccg gacggtgtca gagatgacag aagtgaaaga agccttggcg cgaaaaaaac 479941 aaacagaagc ggttcgccat gcggttgaag aaatcaggat gattaatgaa gcagactata 480001 ttgtcgtcat ggatatgaat cacatccgat atacgcatcc tgtcagcaca agcattggca 480061 agaaatcaga aggtgcagac gaggaggcag cttttgcgga gcacatttat ttctctgaag 480121 caaagggcga gatcggcacg gcggttcgcg ctttttatcc ggtaaaggat caagacctga 480181 accaaatagg cgtggtgctt gtcggaaaaa cgctgccggg gatcgctgac atcctgcttc 480241 atttaaagcg tgatatcgcc ttcatcgttg tgctgacact cggctttggc cttgctggtt 480301 cctttttgct ggcccgccat atcaaaaaac aaatgtttca gcttgaaccc catgagattg 480361 tccgaatgta tgaagaacgg acagcgacgt ttcactcgat gaatgaaggg gtgatcgcta 480421 ttgacaatcg tctcgtcatt acgatcttca atgaaaaagc gaaacagatc tttgaagtgc 480481 agggggatct aatcggcaag gtgatttggg aggttctcaa ggattcgcgc ctgcccgaaa 480541 tcgtggagcg gaacaaagcg gtttataatg aagaaattcg tgtcagcggt aaggtgatca 480601 tgagcagcag aattccgatc gtcatgaaga aaaaagtgat cggcgccgtt gcgatttttc 480661 aggacagaac ggaagcggcc aagatggcag aggaattgac tggtgtcaga aactttgtgg 480721 aggcgctccg tgtccaaaac catgagcata tgaataagct gcacacgatc gccggtctca 480781 tccagctggg gaaatctgaa aaagccttgc agcttgcatt ccaggcgtca actgagcagg 480841 aaaatgtgac tgaatttctg caccgctcga ttcaaaatga cgctgcggca ggccttctat 480901 taagtaaaat cagaagggga agagagctcg gcattgctgt tcatatagat gaaaacagca 480961 gtcttcagca atttcccgag catgttgatc agcatgatat tgtcgtgctt ttggggaatc 481021 tgattgaaaa tgccttcggc tcatttgaaa ccgttcaatc tgaagacaaa cgaattgaca 481081 ttagtatcga acaaacagat gatatccttg ctattttaat agaagataac ggctgcggaa 481141 ttgaaccgac acatatgcct cgcctttatg acaaaggttt tacggtcaat aaaactggcg 481201 gcacaggcta tggcctgtat ctagtgaaac aaatcataga caaaggatcg ggcacgatag 481261 aagttgattc acatgcgggg caggggacat ctttttctat cgtttttcca atgaaggggg 481321 aggaagcaca gcatggctcg taaagaatgg aaggttctgc tcattgaaga cgatccgatg 481381 gttcaagagg tcaataagga tttcattaca actgttaaag gcgttactgt ctgtgcaacg 481441 gcaggaaacg gagaggaagg catgaagctg attaaagaag aacagccaga tctcgtcatt 481501 ctcgatgtgt acatgccgaa aaaagacggc atcaagacct tgcaggagat cagaaagcaa 481561 aagcttgaag tggatgtcat tgtcgtctcc gctgcaaaag acaaggaaac gatctcactc 481621 atgctgcaaa acggggcggt tgactatatc ttaaagccgt ttaagcttga gcgaatgaga 481681 caggcactcg aaaagtacaa gcaatataaa caaaaaatcg aagcgaatga tacgctgtcc 481741 caggaacagc tcgatgcgat cctgaatatt ccgcagcagg ccgtacagga tctgccgaaa 481801 gggttgaatc acttcacgat gaatgaagtc actgcttttt tgaaacagca aaccgcatcc 481861 ctttctgctg aagaggttgc caaggcgctc ggcatcgcca gagtgacagc cagacgatat 481921 cttgattact tagaaaaaac cgggatcatc aaattggacg ttcaatacgg cggagtcggc 481981 cggccggtca accgctacgt gttaaaagga taaacctgag accaaaaaga ccaaaatgtc 482041 cgttatgatc ataaacttcc ccagactgta tgaaaacgct atcattctag taagaaagac 482101 acaaaaggcg aataggacag ggggatgaag gatatgaaac tgtttaaaaa tttaacagtt 482161 caggtcataa ccgcggtcat catcggggtc attgtcgggc tggtctggcc ggatgtcggc 482221 aaagaaatga aaccgcttgg tgatacattt atcaacgctg ttaaaatggt gatcgcacca 482281 atcattttct tcacaatcgt tctcgggatt gcaaaaatgg gcgatatgaa gaaggttgga 482341 aaagtagggg gaaaagcgtt tatctatttc gaggttgtca ccaccctcgc actcattatc 482401 ggtttatttg tcgtcaatat tatgaagccg ggtgcgggtc ttgattacag caagcttgaa 482461 aaaggagatg tatcacaata cacgcaaaat ggcggtcagg gaatcgactg gattgaattt 482521 attacacaca ttgttccgtc caacatggtt gatgccttcg caaaagggga cattttgcag 482581 gtcttattct tttctattct tttcggagtg ggtcttgcgg cattaggcga aaaaggaaaa 482641 agcgtcattg atttcttcga caaggtttct cacgtttttt tcaaaattat cggctacatt 482701 atgcgtgccg cgccaatcgg ggcattcggg gcgatggcgt atacaatcgg acacttcggg 482761 ctcgattcca tcaaaccgct ggcaagctta atgatgtctg tttatattac gatgttcctg 482821 ttcgtatttg ttgctttaaa tatcatctgc aagctttacg gattcagcct gtggaattac 482881 cttcgcttca ttaaggatga gcttttgatc gtgcttggca caagctcttc cgaatcggtg 482941 cttccgcgta tgatggataa aatggagcgc tacggctgtt ccaaatccgt tgtcgggctt 483001 gttattccga cgggctattc gtttaacctc gacggcacat ccatctattt atcaatggcg 483061 actgtctttt tggcacaggt gtttggagta gacctcagca tcggccagca aattacgatt 483121 atcctcgttc tgatgctgac atcgaaggga gcggcaggtg tgacgggaag cggatttatc 483181 gtccttgcct caacgctgtc agcgctgcag gtcattccgc tggaggggct tgcactcctg 483241 ctcggggtcg accgtttcat gagtgaagga agagccattg tgaacctgat cggaaacgga 483301 atcgccacga tcattgttgc caaaagcgaa aatgaatttg atgaagcaaa aagcatagag 483361 gctgttgaag gcatgaaaaa aatgaaaaca gcagtctgaa aaaagaacgg cccatccatg 483421 ggccgttttt ttaattgttt aagaattatt aaggtaagga cagagacctc agcatttttt 483481 tgttatataa tttacaaatg gatactatat tgaatgaagg acgtttgtcc taacaggagt 483541 gtataaatgg ccgctttagt taaatttttt cagcacccgg gagtaaggcg tttctccatc 483601 tttgtcgtgt taactggtgt gttatatcta tttaagagca tgatcaactt aatattgctt 483661 accttcattt tcacatttct aatggatcgt ttggagcttg tcgtgcggca gtttgtaagc 483721 cagttcttcc gcgtgagcca gcgggttgtc attacgtttc tttacatgtt gctggctgtg 483781 ctgcttacag tcgggggctt tgtgttttat ccggtcgtcg cggcgcagat ccagcagctg 483841 gtaaagcaga ttaaacatat tgcgtatcat cctgacagca tccctttctt tgatgagatc 483901 accagtgtct tcggagatat taacatcagt tcatatgtca aagagggctt caatgtagtg 483961 tatacgtatc tggccgatat cagcacattc ggcttgcagg tcgtgatggc gctcattctt 484021 agcatgtttt tcttatttga gaaaaaacgg ctttctgaat tcatggcgaa atttaaaacg 484081 agcaaactta gggtctttta tgaggagatt gcttttttcg gaagcaaatt tgcaagaacg 484141 ttcggcaagg tgctcgaggc tcaatttatc attgcgctcg tcaactgtat tctgacgttt 484201 atcgcgcttt ggattatgca ttttccgcag ctgtttgggc tttcgattat ggtgttcttc 484261 cttggattga tccctgtagc aggcgtcgtc atttccctga ttccgctcag cattatcgcc 484321 tacagcactg gcggtggaat gtatgtgctc tacattgtcc ttgtcatatt cgccattcat 484381 gcgatcgaaa cctatttctt aaatccgaag ctgatgtcgg cgaaaacaga gctgccaatc 484441 tttttcacct tcacagtact cattttctct gaacacttct tcggcatttg gggtttaatt 484501 atcgggattc cgatctttgt gtttctcctt gatattctgg atgtcaccaa caaggaagat 484561 aggtctaaag gaccccgaga gaatagcgat aaaaagtagt ttaaaatcga ataatgagtg 484621 tgcctcgatc tgccggcctg cctgttcagg gcatggaatt aagactcgga atcggagctt 484681 ggcattgcct tgcacagtgg tgaacacaac aggtgacaat gcttgtcatc agtacggaaa 484741 ctgaaaagaa caaacagtcg gagcaaacgc tcatcatcgg tttaaccaaa catttggaag 484801 caacaaatgc tataatacaa acagtgccta atgttgggca ctgtttattt tttgtcgaaa 484861 aaggaggaag gctttatggc tgagccgatt ttacatattg aaggcctcga taaaaaaatt 484921 gggtctaaac agattttaaa acagatcagc atggacgtca tggagggtga aatcatcggc 484981 cttctcggtc cgaatggttc cggaaaaaca acactcatcc gtatcatcgt cgggctgttg 485041 aaacaaaaca gcggaagcgt gacaatcagc ggattccagc atgatacaga gtttgaaaaa 485101 gcgatggaag cggttggagc gattgttgag aaccctgagt tctatccgta cctgacaggc 485161 tgggaaaacc tcaagcactt tgcgaatatg cacaaaaaaa tagcggatga acggcttgat 485221 gaagtggtgg aacgtgtcgg gctgacgtca gcgattcatg ataaggtgaa aacctattcc 485281 cttgggatgc gccagcgtct gggaatcgcc caggcaattc ttcaccggcc gaagcttctc 485341 attctagatg aaccgacaaa cggcctcgat cctgcgggga tgaaggattt tcgggatcat 485401 attaaggaac tcgcagaaat ggaaggaaca gctgtcctgt tcgccactca tttattgcgc 485461 gaggttgaag acttgtgcga ccgtgtcatc atcattcaaa aaggtgagat caaagcggaa 485521 gtcagcttac aaggaaccga tcaaaccaca gaaaaagcga ttatagaagt gcagccgcaa 485581 gaaaaagcgc tcaattggct gacaggcaat caatatcaag ctgagagcca agacgggacg 485641 attgtagttg aggtggcaaa agaaaacata ccggagctga accgatcact tgtcggacaa 485701 gatctgaatg tattttccat tacgccttac acgcagtcac tggaagacga atttataaaa 485761 gcgacaacag ctcatcaaga ggagggagaa gagcttgtct aaattaattt ggaatgaaca 485821 tatgaaactt tttaatcgga aggtcacttt ggtttctctt atcctgatgg ctgtctttca 485881 attcttcatg gcattgatca ttaaacggat tgtcatcagt gccggaacag atgaaaactt 485941 catcggctat ttatcgtata caccgagcct gaacattttg ctgcaggctt taacgatcgt 486001 aattgcagca acaattgttt cgatggaatt tgataaaaag acgatcaaat ttttgctcat 486061 tcgtccggtt aaacgccaaa aggtcttttg gtcaaaatta atcacagtcg tgatggtcag 486121 cttctatttg tatttggcat actacattct ggcattatta ttcggtctct tgttttttgg 486181 cacatcggtg actgcggaat caaagacatt gctggtcaac accttggcgc tgatcgggtc 486241 aaactggctt gaagctgtaa tgatgggatt attcgggctg ctttgttctt cgctgttccg 486301 caatagcgcg gtagcagttg ttgtttcttt tgtcgtttta tacggagcga gtacacttgt 486361 tcagctcatg aagttgtttg aaaacaagtg gggcagcttt ttgctttttg cgaacactga 486421 ctttacgcaa tacagaagcg gagagacagc gttgttttca ggcatgacgc cattgttttc 486481 aattggaatt ctcatcatac atgccatatt cttcatcgtt gttggctggt ggtgcttctg 486541 taaacgggat gttcgggtct aaaggcaagg aatgacattt ttgtgaaaaa gctcacgtaa 486601 atcaatatca tttgatattt tggtttatac taaaggtact gacggaggtg tctcgattga 486661 ggaactttat taccgcttta ccgatcgtat tgctgcttgg attctcattt gtgtcattca 486721 tgtttcagtt tgaacatctt gtttatttca ggctcgcgct tgggttgttt tctctcgtgg 486781 gactgtacat gatatataaa atgaagacgg gcatccgcta ttttatcatc tatctgtatg 486841 ccagctggat tgtgttggcc gcagtgaccg cttttgaaga gccgattttc tcaagctttt 486901 tctttggcgg cctggtgatg acgatgggtt acctgacata tatgctgatt tatctcggca 486961 tgaaacaaga ccgggatgca aatcctgtgt aatcgcgctg ttcccttggg gaacggcgtg 487021 tttttctata ctgggcaaaa ggttaacagt tgcggaaaaa tggcaggaaa tctataatac 487081 atattaaatt tatcggaatt aaaactgggg ggctgccgga tgtcattatt tatacaaaac 487141 gatcaacagc ggcaatggat ggagaaaatc ggacggattg cggatgaatt tcagcaaaca 487201 gctgctgaag atgacgaaca gggacgtttt cctgcagaga aaatacaaaa actgcgtgat 487261 gctgggtata cagcattaac attgccggca tctcatggcg gagggggcat ttctgtttac 487321 gatatgctct tgtttcaaga acggcttgca cggggagatg ctccgacggc tcttagcatc 487381 ggctggcatt tgagcgtgat cggggagctt ggagaaggca acagctggga tgaagacgta 487441 tttgcatttg ttgccaagga agtccaaaac ggagccgtca ttaacagggc ggcgactgaa 487501 gcgaaaaccg gaagcccgac aagaggaggg cgtcccggta cacacgccgt caaaaaggat 487561 ggcaaatggg cagtgaacgg gagaaaaacc tttacgacga tgtcacaagc tctggattat 487621 tttttagtaa ccgcatggat tgaggacaaa caaacaacag gcgtgtttct cattcataaa 487681 gatgatcccg gcttgtcgat tgaagaaacg tgggatatga tggcgatgcg ggcgactggg 487741 agccatgacc ttgtactgaa cgaagtaatg cttgatgaga ataagctggt ggaactgctt 487801 caagggcctc gtggagctaa gccgaatggc tggctgcttc acattcctgc gatttatctt 487861 ggtgtggctc aagctgctcg tgactatgca gtgcaatttg catctgagta ttctccaaac 487921 agcttgaatg gaccgatcaa gaatgtcccg gccgtacagc aaagaacagg cgaaatggag 487981 cttgaactgc tcaatgccag acactttctt ttccatatcg ctcaattgta tgacgatccg 488041 gtgcggcgtc cacacttgac cagcgagctc ggtgcggcga aacatatcgt cacaaacgct 488101 gcgctgtctg ttgttgataa agcgatgaga attgtcgggg ccaaaagcct ggaacgaacc 488161 aacccgcttc agcgctatta ccgtgatgtg cgcgccggtc ttcacaaccc gccgatggat 488221 gacgccgtga tacacaagct ggcagctgaa gcgtttgagt cataaaaaaa agagccttac 488281 cggctctttt tatgtattgt tttgctcttg cagatttttt tgatgcttgc ggtcgatcct 488341 gtcataaata acgttcatca gctttggatt gcccataatc gcctctttgt tttcctggat 488401 cagctgttgg taagttttca ctttacgctt cggcatgctc cggcgccctc ctgacatgtt 488461 tgtattcact ttctaactcc gtcagcgaca attcatacag atgacgcttt gactttttgt 488521 atataccatt ctgtattaac agatgaatga gctgtttttt tctgatttct gcagactgag 488581 gtgtcattgt gtcaccaacc tccaatcaaa cgatattgat aatcattatc aattaacttc 488641 agtatacaat gtccgcaata gcctgtaaag atgaaaagag tcctattctt ggccaattta 488701 caaacattca acaaatcgac aaaaagtttc ccgggcaata atttgctgtc gaaatattcc 488761 gcttcattga acgcaccctg ctatttttca tgttttgaac catactatgt aatagaatgg 488821 aggctggtat tcaatggagc ggacagaaaa tctgaaaaag ggagaaaaag gggcgctcct 488881 caatattttt gcatatgtca tccttgctgt tgtaaagcta gttatcggga ttctatatca 488941 ttctgaagcg ctgagagcag acgggttaaa taatggaaca gatattgttg cgtcagtagc 489001 agtgctgata ggattgcgga tttctcaaag accggctgac agcgatcatc catacggcca 489061 ttatcgggct gaaacaattt cgtctcttgt tgcgtctttt attatgatgg cagtcggcat 489121 tgaagtgtta atcggcggag gaaaagcgat tgcgggcggc acaacggaaa cgccaaatct 489181 tatcgcggca tggacggcgt taggcagtgc tgtgtttatg tatggcatct atttatataa 489241 caaaaggctg gcagcgtcca ttaaaagctc tgccctgatg gcagcggcaa aggacagcag 489301 gtcagacgct tttgtaagtg ccggcgcgtt tatcggtgtt ttttcgtccc agctgaagct 489361 gccgtgggtt gatccggtaa cggcttttat catcggcatc atcatttgca aaactgcgtg 489421 ggatatcttt aaagacgctt cacattcctt aacagacggc ttccatttaa aagatcttga 489481 gccttacaaa cagaccgtcg gcaggatcga aaatgtgcat cgcctaaagg atgtgaaagc 489541 gaggtattta ggcagtacag ttcatatcga gatggtgatt acggttgatc cgaagcttac 489601 agtagaagaa ggccatggag tggcggatga agtagaagac aaaataaaac atgaacacga 489661 tgtcactcat gttcatgttc atgtagagcc tgacgacata aaataaggct gtttaacgaa 489721 ttagcttata tgttcagata aaaattcagt cacttcttca ggcgttttgg cattggcgct 489781 gtgaaggtga gctgtttttt caccgttctt gaaaataagc aggctgggaa tgcccattac 489841 ttggtatttt tcagccaggt caggaagctc gtccttattc agctcatacc agtcgttttg 489901 gttgtattct tccaaaatat cgccgatgaa catattcatg cgtgtgcagt ctgggcacca 489961 atcagcataa aactttacaa tgatttcttt atcagattga atcagttcat taaattgttc 490021 gtttgttgtg atttttttca tatgtcacat ctccttttca atgccatttt aatataaaat 490081 aaaaaggaat tacatacaaa tgcattcaac atcagcatgc ccaaaaataa ttagatcatt 490141 ttccggtgaa aatgataaga tagtaaagat gaattgtagt ggggggagta tccattgaaa 490201 acaagtctag gattagtgta cggaggaaag tcggcagaac ataatgtttc cctgcagaca 490261 gctctggctg taatcaaagc gctaaatact gagaagtttg atatacatcc gatttatata 490321 acagaaaaag gcgaatgggt tagaggcgcc cgtttaactg aacctgtttc aaacgtgaaa 490381 atgcttcaat ttgagcaagg aggcagtgct ttttctccag ctgccctgaa ccaggagatg 490441 tttccgcagg aagcgtcaca gcaaaatgaa gccatcgacg tcgtattccc gctcctccac 490501 ggaccgaacg gagaagacgg tacgatccag ggaatgctcg agctgttgaa cattccttat 490561 gtcggcaacg gagtgcttgc ttcctcagct ggcatggata aagttgtcat gaaacattta 490621 tttgcgcagg ttggccttgc tcaggctaaa tacgcagctt tccttaagaa agactggact 490681 cgttctccga aagaaagctg tgaggaggtt gaacaggaat taggctaccc ttgcttcgta 490741 aaaccggcga acctcggctc aagtgtcgga atcagcaaat gccgaaaccg tgaagaactg 490801 caaaaagcgt ttgagcttgc tttccaatat gaccgcaaag tcgtcgttga agaaggaatt 490861 aacggccgcg agatcgaaat cggcgttctt ggaaatgatg atcctaaatg ctctgttgtg 490921 ggagaaatcg caccgaagac agatttctac gattacaaag cgaaatatga ggatggagat 490981 actgatctga tgattccggc gattgtgact gatgaggaat acgcaacaat cagtgatatg 491041 gcgatcaaag cgtttaaagc gatcgacggt tcaggactcg tcagagcgga ctttttcctg 491101 acagctgacg gcgaagttct gatcaatgaa gtcaacacaa tgcctggctt tacacctttc 491161 agcatgttcc cgttgctctg gaaagaagcc ggagtggaat atgctgacct gattgaacag 491221 cttgtggagc ttgcaaaaga acgccacgct gaaaaacaat tgattaagca tacattctaa 491281 tgaagaagga cactgccggt aaaagggcag tgttttttcc cgtatataca aaagaaagag 491341 agggacctta cttgattaag cgaacagtaa aaaacattgc cgaaatggtt aaaggcacac 491401 tagcaaatcc gcaatatgaa caaacagtca ttcatggagt ggcaaccgat acaagaaaac 491461 tggaacaaca tcagctcttt attccgctga aaggggaacg ttttgacggc cactcttttg 491521 tggagcaggc ctttgaagct ggtgtagcgg ctgttctttg ggatcggtca gtaccaaatc 491581 cgcccgagaa tcacgccgtc attttagtgg acgataccct tactgcactt cagcagcttg 491641 caaaagctta tttgcaggag cttggcacgc gtgtcatcgg agtaaccgga agcaatggca 491701 aaacgacaac aaaagatatg attcacgccg tattggggac ccagtaccgt gtccacaaaa 491761 ctggaggaaa cttcaataat catatcggtt tgccgctgac ggttttagcg atgcctgaaa 491821 atacggagat cgccgtattg gagatgggaa tgagcgccaa aggagaaatt gacctcttga 491881 gccgactggc aaacccggat gcggcagtga ttacgaatat cggcgaatcg catatgcaag 491941 acctcggctc tagagagggc atcgcggagg cgaagcttga aatcataaac gggcttaaag 492001 aagacggagt gctgatttat atcggggacg aaccgcttct tcaaaatgca tacagctgcc 492061 agacgaaaac gtacggtacg ggaacgcata atgattatca gcttcaggat gtcagccaga 492121 gtgaggaagg aacccatttt acaatcaaag ggatagaaaa cacgtttttt attccaatac 492181 tcggcaagca caatgtgatg aacgccatgg ctgcaattgc tgcaggggct tattttggca 492241 tcgcgcctga ggatgcggca aaaggactga gcggcctaaa ggtaaccggg atgaggcttg 492301 aactcatcaa aacagacagc ggcctttcga taatcaatga cgcttataat gcgagcccga 492361 cttccatgaa agctgcaatt caattgacag aaagccttga aggctacggc aaaaaaatgc 492421 tcgtgctcgg tgatatgctt gaactcggcg atcttgaaga aacgttccat aaagagtgcg 492481 gcgctgtgat cagccctgat aaaattgacc gcgtctttac gtacggaaaa ctgggagctt 492541 ttatcgcgga aggcgccctg aaacactttg agaaagaccg cgtcagccat tacactgaga 492601 aaaaagatct ccttcaagct gtgaaggaaa acgcatcaaa aggcgatttg attttattca 492661 aagcgtccag aggtatgaag cttgaagaaa tcgttaaaga tttaatagag agcccgcttt 492721 cataagaaaa tattttgcga aaaaacgcat attgcatcat aaaataacct gatatgcaaa 492781 cactaatgta tgccggccga aaattatgta tatctggccg gctgcggcta tgatacaata 492841 tatataggtt atttcgcgat acgaacatat tcgtccggac ttttcatcgt gacccgaagt 492901 tctccgctgg attcttggga gcggatggag cagcagccgg catattcgag atgccgatct 492961 gcttctcatc ttattgaaaa acaaatagtg taatggtaag ataaaactta aagtaattcg 493021 ggctttgtat acggatggat cctgtccttc ttgtctaaag ggcagtttta taagtggtaa 493081 atcacgacat tactgaaaca gcaattagaa ggagtttgaa taatttgact ataacgtttc 493141 aagattttaa tttaagttct gatctcatga aagcaattaa tcgtatggga tttgaagaag 493201 caacaccgat tcaggcacaa acgataccgc tcggactttc aaataaagac gtcattggac 493261 aagcgcaaac aggtacaggt aaaacagctg cgtttggtat accccttgtt gaaaaaatta 493321 accccgagtc tcctaatatt caagcaatcg taatcgcgcc aacccgtgaa ttagccattc 493381 aagtatctga agaattgtat aaaatcggac aagataaacg tgcgaaggtt cttcctattt 493441 acggcggaca ggatattgga cggcaaatcc gggcgttaaa gaagaatccg aatattattg 493501 tcggaacacc tggacgtctt cttgaccaca tcaaccgccg caccattcgt ttaaacaatg 493561 taaataccgt tgtaatggat gaagcggatg aaatgctgaa catgggattc attgacgata 493621 ttgaatctat cctttcaaac gtgccaagcg agcatcagac acttctgttc tctgccacaa 493681 tgcctgcgcc gatcaaacgc attgcagagc gcttcatgac tgagccggaa cacgtaaaag 493741 taaaagcgaa agaaatgacg gtttctaaca ttcagcagtt ctatttggaa gtgcaagaac 493801 gtaaaaaatt cgatacactg actcgccttc ttgatattca gtctcctgag cttgcgatcg 493861 tattcggacg tacaaaacgc cgtgtcgatg agctggctga agctctgaac cttcgcggat 493921 atgcagctga aggtattcac ggtgacttaa cgcaggcgaa acgtatggtt gcgcttcgta 493981 aatttaaaga aggcgcaatc gaagttctag tcgcaactga tgttgccgct cgcggacttg 494041 atatctcagg tgttacacac gtatacaact tcgacgtgcc tcaagatcct gaaagctacg 494101 ttcaccgtat cggaagaacg ggccgtgcag gaaaaacagg tatggcgatg acgttcatta 494161 caccgcgtga gaaaagcatg cttcgcgcaa ttgaacaaac aacaaaacgc aaaatggacc 494221 gcatgaagga gcctacactt gatgaagcgt tagaaggtca gcaacaggtt actgttgaac 494281 gtcttcgcac aacaatcagt gaaaacaacc tgaacttcta catgacagcg gcagctgagc 494341 tgcttgaaga tcatgatgca gtaacagtgg ttgcggcggc tatcaaaatg gctacaaaag 494401 agccagacga cacaccggtt cgcttaacag acgaagcgcc gatggtcagc aaacgctaca 494461 agaaccagcg ctcttctaaa cgcagagacg gtcaaggcgg cggctaccgc ggcggaaaag 494521 ggaaaagcaa caaccgttct tcctatgaca aaaagcgttc aaacgatcgc cgttcttcag 494581 gtgacagacg ccagaaaaaa tcttactaat ttgatcgatt cagagcccaa aacatgatgt 494641 tttgggcttt tttatgttcg tgatttgtta ttcagcaaac tttcagctga cggaagccat 494701 ttttctctgt atgcttaaga atgaaacctt tctgtaaaag agacgtataa ataacgacga 494761 aaaaaaggga ggtaggtatt tttgagagag cagccaaaaa accaaatcag tccagacgga 494821 ttaaaggttt ggcgacttca agagatcatc atatccgctg tttgcttgct tattgtcatt 494881 gcagttgcag tgttaagcta ttattttcat tggccgtact ggatcagcgg cgtgctcggc 494941 gctgtttggc tgctgggatc gattgtgacg gtctttatca ttccgaaggt ccgtcataag 495001 gtgtggcgat atgaagtcca tgaacatgaa atagatattc agtcaggtat ttttgtggtg 495061 acacgtgtga ttgttccgat ggtcagagtt cagcacgtcg atacgtcaca agggccatta 495121 ttaaaaaaat acaacctggc aacggtgaaa atttccacag ccgcgaccgt tcattcgatc 495181 cccgctttag agatggagga agcggatcgg ctaagagact ccatttcccg tctggcgagg 495241 gtgactgacg atgatgtctg aaccgaaacg cctgcacccg gtggcagtca ttttgaattt 495301 atgccatacc attattcaaa cgataaaaaa tatcattctg ccattctttt ttgtgtatat 495361 tgtcaattca aaccatactg tccgttttta cggagccatt gcgctcggtg tgctgttcat 495421 ctggcttgta gcggcaagca ttatcaaatg gagaaggttt acctatcgaa ttgaagatga 495481 tgaatttaga attgaagaag gcttatttgt tacgaaaaaa cgatacatat cgattgatcg 495541 gattcaaaca atgaatacga gcgcgggcct tgtccagcaa atctttaagc ttgtgaagct 495601 gcaaattgaa acagcaggcg gaggcaagga ggcagaagcc gttctttctg ctatttctgt 495661 tgaagaagcg gaacgcatca aagaagctgt ctttaagaaa aaagcgcaaa gacgagaaaa 495721 tgaacttgat gaagaacggc ttgaagctga agaggagttg gatccgtccg ttgaggtgca 495781 agagcactat cgcatgaacg cgaaagaatt gctcatggcc gcttctacct ccggcggaat 495841 cggagtcatt atctccgctg tatttgcact tatttcccag cttgatgaag tgctgccgat 495901 ggattggtta ttcgataaat tttccttcct tcagcacgcc agcatcggta tttatgcggt 495961 actcattttt atcggtttat ttatcgcctg gattttcagc atcgcgggca tgatgtttag 496021 atacgcgaac tttcaaatca taaaaaaaga gcaggaactg gtgatttcaa ggggaattat 496081 tgaaaaacat caagtcacga ttccgctgcg aaaaatacaa gccattaaaa tcaaagaaaa 496141 tatcattcgc cagcttttcg gctttgtaac ggtgtccatc gtcagcgcag gaggcggcga 496201 ccgggaaaaa gaagaaggcg ctttgaccat tctctttcca atgattcata aaaaaaagct 496261 tccgcacatg ctccgaacat ttacgccgga atacacgctg gaagaaaact gccgccgcct 496321 gccgcggcgc gcgttgaaac gctatttgtt ccgttctgtc attttttcac tctttttgat 496381 catcccgtta tgtatcttct ttcagccatg gggctatctg tcagtgatcc tgctgccgat 496441 agaattgctc ttcggctatc tcgcgtataa agaggctgca tggacgatca acggggaccg 496501 tcttcagctg acgtctagat ttataggcag aacaaccgcc attgtactga aaaaacgaat 496561 gcaggtctgc aagttcagcc aatcctattt ccaaaagaaa ggccgcttgt ataccatttc 496621 tacttcggtg aaatcatcga gccatatgga agagttaacg gtgagggacg taggtgaaga 496681 ggatgcagcc ttcattttaa agtggtactc atatgaaaaa gcggacggtt aataccgccg 496741 ctccagcgtg tcggcaaacc ctcgcattcg ttgtcaggac tgcgcttcgg tgctcaatgc 496801 gaagtggatc aacggctaaa ttctcaggcg tcctgcctaa acgccgtcgt catcacatcc 496861 tgtgaaagtc cgctcctatg ctcgtccttc ctagacttca tgggttttca atcacgctga 496921 aaagatgaca aaatcctaaa atgaaaacca ttttaggatt ttgtcaacaa tctgaagcgg 496981 cggttaatac cgccgctctt ttttttgcac gcataaaaac gaaagaagaa acccgccgca 497041 tagtccaaac aaatgggcca tcatgttaat attggagttg ataaacgaca tgagaacggc 497101 aaatgcgagc agtgtgatga tcattttgga atgctcctgc ccaattaact cattgcgaaa 497161 aagaaccata aacaggtata cgccaaatag cccgaaaatg gcgcctgaag ccccgacatg 497221 cacgtaatca agcggctctg taacataagt gccgatattg ccgatgatgc cggagccggc 497281 gtatacaaga aggaaacgcg cttttcccag catgcgttcc aaagccgggg caaataaaaa 497341 gatggacatg gaattaaaca gcagatgtgt gaaaccggcg tgcagcaaaa tcggtgtgat 497401 aagccgccac cattcaccgt ttgcgacacc tagattatag cctgtgacgg tatccctcca 497461 taacacgact gaatgggcag gaagtgaaaa aaacagccag agaacagctt gcaaagccaa 497521 tataaaggtg acaacggggt aaagcctgat aaatgtttga aaattttcag tccgtataaa 497581 cattccgagc cccttttctt cattttggta tatctatagt aacacgttta tgagacaaac 497641 catttaaata gtacgtacgc aaaggaggtt atcatacatg atttacggca ttgggctgga 497701 cattaccgag cttaaacgga tcgcctctat ggctgggcgc cagaaaaggt ttgccgagcg 497761 gattttgacg cgaagcgagc ttgaccaata ctatgagctt tcagagaaaa gaaaaaacga 497821 atttctcgcg ggcagattcg cggcaaaaga agcgttctcg aaagcatttg gcaccggcat 497881 tgggaggcag ctcagctttc aggacattga aattaggaaa gaccaaaatg gcaagcccta 497941 tatcatttgt acgaaactga gccaggccgc cgttcacgta tcgatcactc atacaaaaga 498001 atacgctgcc gcgcaggttg tgattgaaag gttgtcaagc tagtctgcat attagggaaa 498061 ccccactcat atatttgata gtgcattaag ggagacaagt tgtttgaggc ttttatggta 498121 cgcatctgtt ctgcctaaac gtgtaccgag cgtaccgtta aagtcaaaca agcgatttct 498181 tccttttaca tcaattgaga aaaaggggtt gaaaaaggtg agaaaaagct ttgttttgct 498241 tttaacggga ctgcttgctg ttcttattct ttctgcctgc gggcaaaaaa cacagcaaga 498301 tattgtggcc gggttagatg aaaaggcgaa agaatacacc tcgtacaaag caaaagcgaa 498361 aatgaccatc gagacaggga gtgagcctca agtatacaat gtggaaatct ggcacaaaaa 498421 gccgtctctg tacagggttt atttagaaaa tccgaaaaag gaccaaaacc aagtcatttt 498481 acgaaatgaa aacggagtat tcgttctcac gccgtcttta aataagagct tcagatttca 498541 aagcgattgg ccgaacaaca gcagccaggt ttatctgttt gaatcgctcg taaaggatgt 498601 tcaaaacgat tcggatgcag ttttcacagc gaaagaaaag aaatacgtat ttgaaacaaa 498661 aacaaactat cagcataaca aaatgctgcc cacgcaagaa atcacattta acaaaaaaga 498721 tatgagcccg tcatctgtca aagtgatgga tactgaccgg aaagtgatgg tcaaagtaga 498781 attcagcagc tttgaattta ataaacaatt tgataaagaa tcatttgatg aaaagaaaaa 498841 tatgaccctt tctcaaatgg atgtcgccac aagcgcaaag ccttccgata catttgcggt 498901 caaaacgccg ctggaactgc cgcttggcgt caagctgctt gaagaaaaag atatatctac 498961 tgaagacggg aagcgcatca tcatgacgta cggaggagaa aaatcattta cgttaattca 499021 ggaaaaagcc cagattgcca aggcttcctc ctccgttacg ctgaacggcg aaccggtaaa 499081 tctcggctac accatcggcg ccctgtcgga tgcatcatta tcatggacat atgacggcgt 499141 agattacctt ctctcttcta aagatctttc taaagaggaa atggtgacag tagcgaaaag 499201 catgcaggga caatcatcga aataaccgcc aaaggccaaa catgatttgg cctttttttc 499261 gttagacatc gtttcccttt agcctttaat tttagtatga tatgtaaatg atattgaata 499321 aaagctagga agtgtcgtaa tgagcacaaa acctttttac agagatacgt gggcggaaat 499381 tgacttgtcc gcgataaagg aaaatgtcag caatatgaaa aaacatatcg gtgaacatgt 499441 ccacttgatg gcagttgtga aagcaaacgc ctacgggcat ggtgatgcag aaacagcaaa 499501 ggctgctctt gacgcaggtg cttcatgctt ggccgtggcc attttggatg aagcgatttc 499561 actgcgcaaa aagggattga aggcgcctat attggtgctt ggcgcggttc ccccggagta 499621 tgtggcaatc gctgctgagt atgacgtgac cttaacaggt tattctgttg aatggcttca 499681 ggaggcagcc cgccacacga aaaaaggttc tcttcatttt catctgaagg tcgatacggg 499741 gatgaacaga cttggtgtaa aaacagagga agaagttcag aacgtgatgg caattcttga 499801 ccgcaaccct cgtttaaagt gcaaaggggt atttacccat tttgcgacag cggatgaaaa 499861 agaaagaggc tatttcttaa tgcagtttga gcgctttaaa gagctgattg ctccgctgcc 499921 gttaaagaat ctaatggtcc actgcgcgaa cagcgccgct ggactccggc tgaaaaaagg 499981 cttttttaat gcagtcagat tcggcatcgg catgtatggc cttcgcccgt ctgctgacat 500041 gtcggacgag ataccgtttc agctgcgtcc ggcatttacc ctgcattcga cactgtcaca 500101 tgtcaaactg atcagaaaag gcgagagcgt cagctacgga gccgagtaca cagcggaaaa 500161 agacacatgg atcgggacgg tgcctgtagg ctatgcggac ggctggctcc gaaaattgaa 500221 agggaccgac atccttgtga agggaaaacg cctgaaaatt gccggccgaa tttgcatgga 500281 ccaatttatg gtggagctgg atcaggaata tccgccgggc acaaaagtca cattaatagg 500341 ccggcagggg gatgaatata tttccatgga tgagattgca ggaaggctcg aaaccattaa 500401 ctatgaggtg gcctgtacaa taagttcccg tgttccccgt atgtttttgg aaaatgggag 500461 tataatggaa gtaagaaatc ctttattgca ggtaaatata agcaattaac ttacctaaat 500521 ggagaattca taaaacagct ttgcttgaag agtgaataat ggtatcatta tcactggatg 500581 gataaaagag tcgtatccgt aagtttggtg gaggtgtatg ttttttgtct gaatccagcg 500641 caagaaccga aatgaaaatc agcttgcccg aaaacctagt agctgaattg gatggtgtag 500701 cgatgcggga gaaacgaagc agaaacgaac tgatatcaca agcagtgaga gcgtatgtca 500761 gcgaacgaac aactcgtcac aaccgtgatt tgatgagacg cggctatatg gaaatggcga 500821 aaatcaacct gaatatttct tctgaggctc actttgcgga gtgcgaggct gaaacgacag 500881 ttgagcgctt agtcagcgga ggataatcat ttgattgtga aacgcggcga tgtttatttt 500941 gctgatttat ctcctgttgt tggctcagag caaggcgggg tgcgcccggt tttagtgatc 501001 caaaatgaca tcggaaatcg cttcagccca actgctattg ttgcagccat aacagcacaa 501061 atacagaaag cgaaattacc aacccacgtc gaaatcgatg caaaacgcta cggttttgaa 501121 agagattccg ttattttgct ggagcaaatt cggacgattg acaagcaaag gttaacggat 501181 aagattactc atctggatga tgaaatgatg gataaggttg atgaagcctt acaaatcagt 501241 ttggcactca ttgattttta gacatatttg caggttgctc aaatagagca actttttttg 501301 ttttcaaaaa acataaacga tataatagtg aaataacgaa aaaatatgtt gttttttatt 501361 gggaggtaag cgaatttgat gtcgaaccag actgtatacc agttcattgc cgaaaatcaa 501421 aatgaactgc tccaactgtg gactgacaca ctaaaagaat taagcgagca agaatcctat 501481 cagctgactg accaagtgta tgaaaatata tctaaagaat atatcgacat tctgctgctg 501541 tctgttaagg acgaaaatgc tgctgaaagc caaatcagcg aactggcgct tcgagcggtc 501601 caaatcggac tgtctatgaa gtttttggct actgcacttg ccgaattctg gaagcgtctc 501661 tacacgaaaa tgaatgataa gagattgcca gatcaagaga gcacggaatt aatctggcag 501721 attgatcgct ttttcagccc gattaacaca gaaattttta atcaatactc aatctcatgg 501781 gaaaaaacag tatccctgca aaaaatcgcg ctgcaagagc tgtctgcgcc gcttatcccg 501841 gtgtttgaaa atatcactgt gatgcctctt gtcggaacaa ttgataccga acgcgcgaaa 501901 cgaattatgg aaaaccttct taatggcgtc gtcaaacacc gttcccaagt cgtgctgatt 501961 gacattacag gtgtccctgt cgtcgatacg atggttgccc atcatattat tcaggcatca 502021 gaagctgtaa ggcttgtcgg agcaaaatgc ctgctggccg gaatccgtcc ggaaattgct 502081 caaacaatcg tcaacctggg gattgattta tcccaagtta taactaagaa taccctgcaa 502141 aaaggaattc aaacagcatt ggaaatgacg gatcgaaaaa tcgtttcatt gggggaataa 502201 cattttgaga catccgaaaa tcccgatctt gaaactgtat aattgcttat tagtgtccat 502261 tcagtgggaa cttgatgacc agacagcatt aacttttcaa gaagacttat taaataaaat 502321 atacgaaaca ggtgctaacg gagtcgtcat tgacctgaca tctgtggata tgattgattc 502381 atttatcgcg aaagtgctgg gggacgtcat tacaatgtct aagttaatgg gggctaaagt 502441 cgtcttgacc ggcattcagc ccgctgtggc agtgacgctg attgaacttg gaatcgcgct 502501 tgaggaaatc gaaactgcgc tcgacttaga gcaggggctt gagacattga agcgggaatt 502561 gggggaatag cgaatgaacg accaatcctg tgtaagaatc atgacagaat gggatattgt 502621 ggccgccaga cagctgggac gaaacgttgc gaaagaactg ggtttcggca cggtagacca 502681 ggctagaatt acaacggcta tttcagaatt agccaggaat atttatttat atgccggcaa 502741 agggcagatt ggaattgaac aggtcgcaga cagaggaaaa aaaggcctga aaatcatagc 502801 ggaagaccaa gggccgggaa ttcctgatat ccgaaaagtc atggaagacg ggttttcaac 502861 gtctggagga cttggtgcgg gacttcccgg ggtcaaaagg ctgatggatg aattcagctt 502921 aaattccgta gcgggggaag gaacagagat acaagccatc aaatggcttc ggtaggaggt 502981 aagaacgtgg attttaggga ggttattgag cagcggtatc atcagctgct tagtcgatat 503041 atagccgaat taacagaaac atctttatat caagcccaaa aattcagccg aaaaacaatc 503101 gagcaccaaa ttcctccgga agaaatcatc agcattcaca gaaaagtgct gaaggagctg 503161 tatccaagtc tcccggaaga tgtgtttcat tcgctggatt ttttaataga agtcatgatt 503221 ggctatggaa tggcttatca ggagcatcaa acccttagag ggatacagca ggaaatcaaa 503281 tcagaaattg aaatcgcggc aaatgtccag cagacgcttc tcggaactaa agttcctcag 503341 gaggaagcgc tggatatcgg cgccatcagt gttcccgcta aacagatgag cggtgattac 503401 taccactttg tcaaagacaa ggaatccatc aatatcgcaa tcgcggacgt gatcggaaaa 503461 ggcattccag cggctttatg catgtccatg attaaatacg caatggactc tttgccggaa 503521 acgggcatac acccttctca agtgctgaaa aatttgaatc gtgttgttga acaaaacgtt 503581 gatgccagta tgtttattac gatgttttat gcgaattaca atatggacaa gcatcaattt 503641 acatatgctt cagcgggaca tgaaccggga ttctattatt ctcaaaaaga caacacgttt 503701 tacgatttag aggccaaagg actcgttctc ggcatctcgc aggactatga ctacaaacaa 503761 ttcgatcagc atctggaaaa gggcgatatg attgttttat tttctgacgg cgtcacagaa 503821 tgcagaacgg aaaacggttt cttggagcgt cctgatctgc agaagctcat tgaggaacat 503881 atgtgttcct ctgcgcagga aatggtcaaa aacatttatg acagcctcct caaattgcag 503941 gattttcagc ttcacgatga ttttacgtta attgttttgc ggagaaaggt ttaacgtctg 504001 tcagacgagg gtataaagca actagtgatt tgaaggaaaa tttgaggtga tacgaatgaa 504061 tataaatgtt gatgtgaagc aaaacgagaa tgatatacaa gtaaacattg caggagaaat 504121 tgatgtatac tcagccccgg tgcttagaga gaagctcgtt cctctggcag aacaaggagc 504181 tgacttaaga atttgcctga aagatgtcag ctacatggac agtaccggat tgggcgtttt 504241 tgtagggacc tttaaaatgg tgaaaaaaca aggtggttcg ctgaaacttg aaaatctttc 504301 tgaacggctg atccgactgt ttgacattac aggcttgaag gacatcattg atatttctgc 504361 aaagtcagaa ggtggagtgc aatgaagaat aatgctgatt acatcgaaat gaaagtgccg 504421 gcccaacctg aatatgtggg aattataaga ctgacgctgt caggggtcgc aagcagaatg 504481 ggctatacgt acgatgaaat tgaagacttg aaaatcgcag tcagtgaggc gtgcacaaat 504541 gcggttcagc acgcttacaa agaagataaa aatggggaag tgtcaatacg attcggtgtg 504601 tttgaagacc gtttagaggt tattgtggcg gatgaaggag acagctttga ctttgatcaa 504661 aagcagcagg atctagggcc gtacacacct tcgcacacag ttgatcaatt atcagaagga 504721 gggctcggtc tatatttaat ggaaacgctc atggatgaag tcagagtgca aaaccactcc 504781 ggcgtcaccg tagcgatgac aaagtattta aatggggagc gagttgatca tgacacaacc 504841 atcaaaaact acgaaactaa ctaaagatga agtcgatcgg ctcataagcg attaccaaac 504901 aaagcaagat gaacaagcgc aggaaacgct tgtgcgggtg tatacaaatc tggttgacat 504961 gcttgcgaaa aaatactcaa aaggcaaaag cttccacgag gatctccgcc aggtcggcat 505021 gatcgggctg ctaggcgcga ttaagcgata cgatcctgtt gtcggcaaat cgtttgaagc 505081 ttttgcaatc ccgacaatca tcggtgaaat taaacgtttc ctcagagata aaacatggag 505141 cgttcatgtg ccgagacgaa ttaaagaact cggtccaaga atcaaaatgg cggttgatca 505201 gctgaccact gaaacacaaa gatcgccgaa agtcgaagag attgccgaat tcctcgatgt 505261 ttctgaagaa gaggttcttg aaacgatgga aatgggcaaa agctatcaag ccttatccgt 505321 tgaccacagc attgaagcgg attcggacgg aagcactgtc acgattcttg atatcgtcgg 505381 atcacaggag gacggatatg agcgggtcaa ccagcaattg atgctgcaaa gcgtgcttca 505441 tgtcctttca gaccgtgaga aacaaatcat agaccttacg tatattcaaa acaaaagcca 505501 aaaagaaact ggggacattc tcggtatatc tcaaatgcac gtctcgcgct tgcaacgcaa 505561 agctgtgaag aagctcagag aggccttgat tgaagatccc tcgatggagt taatgtaatg 505621 atccaggttg aagaaaacga gcatattcaa actctagtat atcaactgaa taaagaaggg 505681 aaatcgattt gcggtgacag tttttttatg aaagctgatg ataaggagtt aatttgcgcg 505741 gttgctgacg gactgggaag tggatcactt gctaacgaat cctctgcagc catcaaagac 505801 ttagtggaaa actatgcgag tgaagacgta gaaagcatta tcgaacgctg taatcaggcg 505861 atgaaaaaca aaagaggcgc tacagcatct atcctgaaaa tcaattttga gcaaaggcag 505921 tttacgtact gctctgtcgg aaatgtacgg tttattctgc attccccgtc tggtgaaagc 505981 ttttatcctc tgccgatttc gggctattta tcaggcaagc cgcaaaaata caaaacgcac 506041 accgccacct atgaaaaggg ttcaaagttc attatacata cagatggact caacgtacct 506101 gatatccgct cccatttgaa aaaaggccaa tcggtagaag aaatatcgaa ttcgctgaaa 506161 atgtatacga catcgagaaa agatgacctg acctatattc tcggacagct gtcctaaaaa 506221 accagaaaaa gaagctggac atccggcttc ttttttttgc ggttgactat taataagtgc 506281 gcttattata attaataagt gaacttatca ttctgggagc ttatgggatg tggaattatg 506341 aatacacagc gatagctgat gtggatgtgg gaaaacctgg aactgttatc aggaaacaga 506401 aacaatggat caatgggaga cgggtattgc atcagattct ttgaaaggac aatttcaaaa 506461 tggaacggaa ggaacattgc ttctgcaagg aaaaacaatt ctcttatggc ttgagcatgt 506521 ggagaaacat cgggcgtttt ctgtcatggt caacatgccc gcatagcaat gtaataatgg 506581 agttttttca cgtgcttcaa aagcaaaaag aagatttgtg tatcacatat ggaattgtat 506641 tagaaggcgc tgaagcaaaa aagtggggag aaatcattgg gactgaactg tctaaagaca 506701 tgccgacggc tgtcagcagg cttgtccatc tttacggagg agtgataaaa tgaacacaaa 506761 ttactggatc ggcgttgtgt cagagcaaca tgtattaaaa ggcgctgccg gcggttttgc 506821 acagctgtgc catggaaaaa aagccccgct cgccaaaatg aaagagggag attggctgat 506881 ttattattct ccgagagacg catatccaga cggcaaactg ctgcgaagct ttactgcgat 506941 cggcaaagta aaaagcggaa acatctatcc gtatcaaatg gctccgaatt ttattccata 507001 ccgattagat atagactatt atccatgcca taaaatcggt ttttacgaca ttaaatcaaa 507061 gcttgaattt gttcaggaaa ccaagcatct tggcttttta tttcgcagag gacactttga 507121 aataagcaaa aaagattttt tgacaatagc acaagcgatg ggagttaaca taagtggaat 507181 ggcactctaa atttagcggt ccgaacacaa gcccgggctt tttattatgg caggccacgc 507241 aaagttggca gcggaaagta ggaaaagcat tggctgagtt tgacctgacc cacgttcaat 507301 ttgttctgct gacctcgtgc aagtatatga ttgctcacgg agaaaccgtc acgcaaaaaa 507361 aacttgcaag cttcagccag accaatatca tgatggtttc ggaggttgtg cggacgcttg 507421 agaaaaaagg atttatcgaa agaagcaaaa atccccagga taaaagagag gtcctcctgt 507481 ctcttacaga aataggagga gaaaaagtaa cagcggcttt gccaattgtt gagaagattg 507541 atcaagcctt ctttgcagct gcgatgaaaa aagagaattt tctgagcggc ttacaggaac 507601 tattgaaaca tgagtaaaga tacgggcagc gccagctgtc tttttttatg tgtttttttc 507661 ggtttttgat acactagaga aagaacgaca aaattggagg ctttggttac atggaaacgt 507721 cagccctttt aaaacagcaa attgcgaaag aaataggttt atcacaaaaa cacgttgaaa 507781 gtgtcatccg cctgcttgag gacggcaata cagtcccgtt tattgcccgg tatcgaaaag 507841 agcagacggg ttcaatggat gaggttcaga ttcagacgat ttctgaacgc tggcaataca 507901 tacaaaacct gaatcagcga aaagaagaag tcatcaggct gattgcagag caggataaac 507961 tgacagataa tctaaaacgt aaaatcgagc aatcggtgaa gcttcaggaa gtggaagacc 508021 tttaccgccc ttataaacaa aaacgtaaaa caaaggcgac agtcgccaaa agcaaaggcc 508081 ttgagccgct tgccgactat atcctgacac ttccccaaga tgatcatctg gcagcaactg 508141 cagaccaata catcagcgaa gaaaaagaag tgttcacacg agaagaagcg attgaaggcg 508201 ccaagcacat tattgcggaa caaatctcag acgagccgac cttcagaaag tggattcgcc 508261 aggaaacctt caaaagagga accattaagt ctgcagccgg aaagtcggca gacaccgatg 508321 agaaaaatgt gtatgaaatg tattacgagt atgaagagcc aattgcaaaa gttgttccgc 508381 atagggtgct ggcaatgaac cgcggcgaaa aagaagacat tttaaaggta gcgatcgaac 508441 cgcctgcgga tcacattaag gcgtatttag aaaaacaaat catcaaaaat cgctcaacat 508501 ccgtaagaga gattttgcag gagacaattg aagacagcta taaaaggctg atccagccgg 508561 caatcgagcg tgaaatcagg aaagagctct cagaaaaagc tgatgaacag gcgattcata 508621 ttttctcaga gaacttgaga aagcttcttt tgcagccgcc gatgaaaggc aaaaccgttc 508681 tcggtgttga cccagccttt cgaactggct gtaagctcgc tgtgtcagat gagaccggaa 508741 aagtcttgaa aattgatgtg atctatccgc atgcgccagt caacaaaaca aaagaagccc 508801 atgaaaaagt gaaaaagatt cttgagcagt atcaagtcga gatggtggcg atcggaaacg 508861 gcacagcatc cagagaaaca gagcaattca tcgtcaatgt actcagagac atgccgcgca 508921 aaatttatta tgtgatcgtc aatgaagcgg gagcaagcgt ctattcggct tcagagcttg 508981 ccagagaaga attccctgac cttaaggttg aagagcgcag tgccgtatct attgctcgga 509041 gacttcaaga cccgctcgcg gagctcgtta agatcgatcc gaagtctgtt ggtgtcggac 509101 agtatcagca tgacgtcagc caaaaacgct taaatgaatc tctgcggttt gtcgtcgaaa 509161 ctgtcgtaaa ccaggttgga gtaaacgtca acacagcctc cgccgcgctg cttcaatatg 509221 tagctggatt atcgaagtct gtagcaggca acgttgtcaa aaaacgtgag gaaatcggaa 509281 agttttcaaa tcgaaaagaa ctgaaggaca tcccaaggtt aggtgcgaaa acctatgagc 509341 aatgtatcgg tttcttaaga gtgcaggaag ggacagagcc tttggataga acaggcatcc 509401 acccggaaag ctataaagaa acaaaagcac ttttgaaaaa actcggactt tcaacagaac 509461 atatcggcac ggcggaattg aaggacaaaa tcaatcagct ggcgctctct gaaacggcaa 509521 aagagctggg aatcggcgaa atcactctga aagacatttg tgaacagctg acaaggccgg 509581 aacgcgatcc acgcgataag gtgcctaagc ctttgctgaa aacagacgtc cttcagctgg 509641 aagatttgaa agagggaatg gaactgcagg gcaccgtgcg caatgtagtg gacttcggag 509701 cgtttgttga tatcggagtc aaacaagacg ggcttgtgca tatctcaaaa ttgagcaatc 509761 aattcgtcaa gcatcctctt gatgtcgtat ctgtcggcga tattgtgaca gtttgggttg 509821 acggcgtaga tgtacaaaaa ggcagagtat cgctgtctat ggtaaaataa aagcactgct 509881 tacgagcagt gttttttcct atagaaatac cagcattgat tcagcagttt aatttggtaa 509941 ttatcttttt caaggaacgc tttttgcatc tgctttttaa gccaatttgg cataggctca 510001 ttcctcctca gcttttatca taagagggac agtgattacc atattgtatg cgaacggtga 510061 attgtcccgt tcaatgtttt ttaagtgagg tgcaccatgg ataacaaaga gcttcaaaag 510121 ctgacagagg atatttctga aacatatttt aaaaagccgt tccgccatca ggcgcttttt 510181 aatgaccggc ttaaaaccac tggcggcagg tacctgttaa cctcccataa cattgaattg 510241 aacagaaaat atttgattga acacggcagg gaggaactga ttggcatcat caagcacgag 510301 ctctgccatt atcatcttca tcttgaagga aaagggtaca agcacagaga cagagatttt 510361 agaatgctat tgcagcaggt caacgcgccg aggttctgta caccccttaa gaaaaaagcg 510421 gaaaacaaaa aaacttatat gtatatctgt acgacctgcg gccaacagta tataaagaag 510481 cgcgccatga accctgacag atacagatgc ggaaaatgcc gcggaaaaat aaaaagaatt 510541 ttttcgtgaa aaaggttgac gaatatggca agcctatgtt acattataaa agtcgtcacg 510601 agagataaat aaaaacattt acctcttgac actgcaaatc aaggctgata taataagtct 510661 tgtctcatta ttccacagta gctcagtggt agagctatcg gctgttaacc gatcggtcgc 510721 aggttcgaat cctgcctgtg gagccatatt ggagaagtac tcaagtggct gaagaggcgc 510781 ccctgctaag ggtgtaggtc gcgtaagcgg cgcgagggtt caaatccctc cttctccgcc 510841 ataagatttc gatataagtt ctcaaccatc ggcccgttgg tcaagcggtt aagacaccgc 510901 cctttcacgg cggtaacacg ggttcgaatc ccgtacgggt cattccattt cgttgggcta 510961 tagccaagcg gtaaggcaac ggactttgac tccgtcatgc gttggttcga atccagctag 511021 cccagccatt tttatttttg aaatctaata gtaagagcca ttagctcagt tggtagagca 511081 tctgactttt aatcagaggg tcgaaggttc gagtccttca tggctcacca tttgtctttt 511141 tgcgggtgtg gcggaattgg cagacgcgct agacttagga tctagtgtct tacgacgtgg 511201 gggttcgagt cccttcaccc gcactttatt tacaaagtgc acgcaaatct gttttactag 511261 gttaagagcc tactaaacca gcacaacaca atttaatgat cacgcggtcg tggcggaatg 511321 gcagacgcgc taggttgagg gcctagtggg tgaataaccc gtggaggttc aagtcctctc 511381 ggccgcatca atgataccaa gggttttgac acccttggta tttttttgtg tttattttca 511441 aatgatttac tgcccacaaa ctgcccactt acctaaagta agtcatctaa tttatcagcc 511501 atttcctttt gcttgtttgg atataggtgt ccataaacat caattgttgt ttttacagaa 511561 ccatgtccta aacgctcttt aattgttatg taatcttctc cttggtgtat taatagtgca 511621 acgtgtgaat gtctaaaatc atgtaaacgt ataggagtaa gatcgctatc cttgcaaaag 511681 tatttaattt tccgactgaa aatatctttt cttgaaggtg tatctttata ttgaaagata 511741 taggtatcat gtgaatgtct aatacctaat tcattaaaca actcttcttg tgcttctttc 511801 caacgttcta gtagcttaag caatttttta ttgatgctaa ctcgccgaat cgaattttta 511861 gtttttggag tagtaacaac aaattgacca tcaagccagg tgcacgattt atgcacatct 511921 atttctaata agattttgtc aatatctttc cattgcaggg cgagcatttc accacatctt 511981 agtccagtta aaaaagcaac agtgtaaaag gttttaaaca ataattgatc ttgaggaatt 512041 aaactaataa attttttgaa ttcttctggt ctccaaaact tcattttctt tcttgttaaa 512101 ggtaatcgtt taacgttgtc acacggattt ctttttaaga tttcttcatg tacagctgta 512161 tcaaaaattt tgcttagact agtcattata ttattaaccg atttattgct tagacctgtt 512221 tccattaaat gttttctgaa atcagttatt tctctatgtg tgattttttg tatatcagat 512281 ttcaaaaagt aatcagatat atgtttgttt ataatgtact tctgattctg ataatagttt 512341 ggtttactat ctatttcaca acttgctaaa taaattgaaa ttagagtcgg aaagcttact 512401 gatctggact ttcttgctct ttcttcttga aattctcttc ttaattttgc ttctaattct 512461 aaagcctctt ttctggttga tgctactggt ctcgtcctaa ttctttctcc agtaatcggg 512521 tcaaatccaa agctaacgtc aacttgatat tgaccatttt caagtttttt tacagacatt 512581 ttatttctcc tttaaccaaa agcgcttatt tcgtgtgaat agattctgtt actaaatgag 512641 ccaatttgag aaagtttata atcagtaaca aatgatggta cgttgaagta tgctgctatt 512701 tgttctttgc taaaaccctg tatatatgga agggcttcat taagcatttt atctgtcagt 512761 attaattctg atgcaaatag gcttgcttga tgctcaagtt tatcttttag aactttagag 512821 caattcacaa ctttaaaagt gttcaatctt ttatggagaa agtaatgccc taattcatgg 512881 gcaattacaa attgttgatg ttggaggttc tcgttgatat ggattaaata ttgatctgtg 512941 gctttgtcat gttgtagtaa accgtttgct tgtccaagat catttttgag tatataaatt 513001 ttttggatgt cacaaatttc atagacatta tttgtaccat gtgtcttaat tactgattgc 513061 actttatgtt taattccttt gcttgtataa attgttatca ctctttcttc tttaattcgt 513121 caatgaattt aattccgttt tttaatgctt ttttaacaag gcgtgcagtt tcctcatcaa 513181 attcaccatc attcataaaa aggagtgtat cttcatcctt taattcctgt atggcttcat 513241 taattgtttt attgagtaaa tcagtttcgt ttttcttgct tacttcatcc tttcctaata 513301 aatagtctgt agatacgtta tataagttgc tcaattttaa gagtgtgtct gtatcaggat 513361 ctctgtaatc tctttcgtaa ttagacaagt tattgttacc gatattaagt ttctctgcgg 513421 cttctttctg agtgtaccca gctttttgtc gagcttcttt taatcgtttg cctaggctca 513481 tttttatcat ccatttcaca aagagttgat ttttataaaa ataataacaa cattttttgg 513541 agaattcatt aatttcacct ataagttaaa taaataattc taaattctcc ttttaggagt 513601 gtttgtttct tctttatgga gagtttaatt atcaatattt ccatatatgt tcaaaaaaat 513661 acactttaag gtgaattttg tgttgactta cacgaaaagg agttttataa taaagttaat 513721 tcacaaagag ttgagttaac gaggaggtga tattttgaaa ggagagtttt taactgcgag 513781 agatattcaa aaaattcttg gagttaaaca ggctaaatct tatgacatca ttagaacttt 513841 gaatgctcaa atgaaagaag aaggatatat ggtcattcaa ggtaaggtga gtagagctaa 513901 gtttgaagag tgttattgtt acaaaggccc aaaatctcaa acggggtgat ttttataaac 513961 attgatataa caaactcgtt tatgaaagaa gctgtccctt tagctagaca aatggaaggt 514021 gattggatag cacgaatgaa aattgctctg aattcagtca ttataaatca ttatttaaac 514081 cttcccttaa caattgaaaa tgttaatgaa ttactgcgaa aaggcgtttc atatcgcagg 514141 atatgtaagc attacggcat tggaagaaaa gacattgaaa agcttcggca atcatccgta 514201 gtgtgacgtt atataccact atagggagcc gttaagaatc ctttgaaagg agggatgcga 514261 tgaaaataag agtgaatgca acaatcatta ctgatgttga agctttaaag gctgataagg 514321 atttgaatca ttttaaagac tatgccactt gtgaaacatt cgttgttgat gctgataatc 514381 atttgaaggc taatgaagaa atatctgagt tgttaaaagg ctgggattgg tggtgtatct 514441 ggtcaactcg tccattgagt aaaaaggata accaagtgtt tactttgtat aacgatgatt 514501 tgtataactt atgtcgatag gagtgtttgt tccttgaaaa ctacatatag acaaaaaaag 514561 cgccttgacg aatgatcatc aagaacgccg gaaaataaaa actagacact tttattatac 514621 ggtattcttg ttgaaatgtc atgcgtgagt atttgagtga tgaacagcaa tcactttaaa 514681 tgctgtagca ggctagaata agcgtgcgga atagctgtag tcagcttgat ggctataatt 514741 agcctactag gttgccatga gggcgtaaag ccgttagcaa ctgataagcg ccaagatgga 514801 tacagaaccg gagcgaatca aaaacataaa atcgaaatta atgttctttt gtaaataaat 514861 tataaaaaaa tgaaatgggg atatgaaaaa tgaacttaaa ctttattgta ccggatatca 514921 atatgacttt tggagacatg aaattcatgg gacttaacag agaaaggtat gtttatgatc 514981 gtgaaaataa taagcgtact gacgtactgg aatctaggat ttataacatt gctagtgctg 515041 tccaaggtgg tcaaattgaa gtaactattc ctgagtatgc tggggcaaaa gaaattcctc 515101 cttttgcaga tattgagttg aaaaatccaa aaattagcgc tatggcgact agtcaaaggg 515161 attcgacgta tgccaatgtg atgtggaaac ttgaagctga tgatattgtt gttaaaggtg 515221 gctcttctgt gaaacctgcc gcggcaactg gcgggaatga aaagaaataa catgatgctc 515281 tcatatcggc aggcgggtga tgtatatgag tgatttctta aacaaaagat tttggaaata 515341 caggggcaaa cgaatccgcc cgtacatgag aaacaacgta aagttagcag gcgcaatcat 515401 ctttgtgcct gtttttttat tgtctatgtt ccttttttgg agagaacaac tcattcattt 515461 tgatctatct caagtgataa aaaattttga atggaatgtg cctttaatca ttaaaagcgt 515521 tttatgctct gtgctaattg ctgttggaag catagttgca tcttactttc ttttgtttga 515581 cagctataag aaaatccttc acaggcaaaa gattgctaaa atgattttct ctaacaagtt 515641 ttacgaaaaa gaaaacgtga aagtaagaaa aatcttttca aatgaaactg actcaaagga 515701 aaagatcaca tactttccta gaatgtatta ccaggtcaaa aacaaccaca tctatattcg 515761 tattgctatg gacatgagcc gttttcagaa tcgcttccta gacttaggaa aggatttgga 515821 aaacggctta ttttgtgact tggttgataa acaaatggaa gaaggttttg tatgctttaa 515881 gcttctttac gatgtcaaaa agaatcgtat ttccattgat gatgcagtag ctgagaatgg 515941 agtccttccg ttaatgaagc atatctcatg gcaatttgat aagttgccgc acatgcttat 516001 tgctggtggt acaggtggag ggaaaacata cttcatgcta acgatcatta aggcatgtgt 516061 tggactgggg gcagatgtaa gaatactaga ccctaaaaat gcagatttag cagacttgga 516121 agaagtactt ccgaaaaagg tctattccca aaagaacggt attcttatgt gcctgagaaa 516181 gtctgtagat ggcatgatgg aacgaatgga tgaaatgaag caaatgtcta actataagac 516241 aggtgaaaac tatgcttatt taggcttaaa acctgttttt atcttctttg atgaatatgt 516301 ggcatttatg gatttgttag atatgaaaga aagaaacgaa gccctttctt acatgaaaca 516361 gttggtcatg ttggggagac aggcggggta ttttctcgtt ttaggcgcac aacgtccaga 516421 tgcaaaatat ttagctgacg gtattcgtga tcagtttagc tttcgtgttt cattgggttt 516481 aatgtccgat acgggttacg gaatgatgtt tggcgatgtt gaaaaagcat atgtgaataa 516541 aaaggagaca gggcgaggat atgccaatgt gggcacaggt tcagtgttgg agttttacag 516601 ccctatcgtg ccgaaaggat atgattttat gtcatctatt aaaaatgcgc tggttggagt 516661 cgagggagcg caggcgacgg cagtcgccag cggcagcgta agcgaccaga cggccagcgg 516721 cgaaggagtg agcgaagcga atggatgagc taaaacaacc cccccacgct aacagggggg 516781 tagtaatcgt aaaagaaaaa aatgaagccg ttgaaagtcc tttggtatca atggttgact 516841 atattcgagt ctcttttaaa actcatgatg ttgacagaat tattgaagag gttcttcacc 516901 ttagcaaaga ctttatgact gagaaacaat ctggtttcta tggctacgtt ggcacgtatg 516961 aactggacta tatcaaagtc ttttattctg cgccggatga caacagaggt gttttgatag 517021 aaatgtccgg tcaaggttgc cgtcaatttg aatccttctt ggaatgccgg aagaaaacat 517081 ggtacgactt ctttcaagat tgcatgcaac aaggcggttc gttcactcgc tttgatttag 517141 ctattgatga taaaaagaca tacttttcta taccagaact gttaaagaaa gcccaaaagg 517201 gcgaatgtat ttcacgattt agaaaatctg atttcaatgg ctcctttgat ctatctgatg 517261 gcattacagg cgggacgaca atatatttcg gttctaaaaa gtcagaagcg tacctttgct 517321 tttatgagaa aaactatgaa caagcagaaa agtataacat tccgttagaa gaactaggcg 517381 attggaatcg ttatgaattg cggcttaaaa atgaacgtgc acaagtggcg atagatgctt 517441 tattgaaaac aaaggattta accttaatcg ctatgcagat cattaataac tatgtaaggt 517501 tcgttgatgc tgatgaaaac atcactagag agcattggaa aacgagcctt ttttggtctg 517561 attttatagg cgatgttggg agacttcctt tgtacgtcaa accacaaaaa gacttctatc 517621 agaaatcaag aaactggctt cgtaactctt gtgctcccac tatgaaaatg gtgcttgaag 517681 ctgatgaaca tttagggaaa accgatctgt cagatatgat tgcagaagct gaactggctg 517741 acaaacataa aaaaatgtta gatgtgtata tggctgatgt tgctgacatg gtcgtttaaa 517801 accaagctgc taaaccttaa taaacacagg tgatgcgatt aaacgtatgt gtcaacggta 517861 ccggaacgaa gtgaggataa ggagttgaca tattcagcgc tacccaaacc ctcttggcat 517921 tgaacaaaca accgtttgtt cctgcctacc ggcgagggag tcccccgatg attcggggga 517981 atagggggat agattaacag caatccaacg agctaccgtt ggtgggtttg ggtgaaaccc 518041 aagaactaac ttggagggat aagatgcata atgtcaatct gttgaatcag gctggactgg 518101 aaaatgcttt ggaatcagtt ggctgtttag atattgtaga agatttaata gaaaagatgc 518161 aggaatatgt tttgtatcat accgaaactg ccgaaagatt tgcgattgat atctttacag 518221 tagtaaacaa ctacactaaa aaggttcatg cgatatttaa tgttcttgaa aatgaagacg 518281 gtgagacaaa tgttaaaaat gtagaatttg aagtaatgca ttttacggag taaggacaat 518341 tttccttatg actttaaagg gggaacatca ggtgtttaat attaatctgt tgaatcaggc 518401 ccgacttgag agtgatttgg attcccttgg gtgtttggat attgctgagg aactgattga 518461 aaaaatgatg gaagatgttt tttacagtga tgtagctcaa agaatcattg ttcaaacact 518521 tgctgttata aataacgcca atgcaaaact tcaagctacg tttaacatct tagaagatga 518581 agatatggag acagacgaac gaagcgtgga gtttgaagga attagctact acgaataagg 518641 ggtgaaaatg tgcggtgtct gctgtagata aacgattcaa aagcttaggt tttaatgtgg 518701 gcattccctc tttagttttt gtgagaagtt taagcagaga ttgcatgttg gttgttgaag 518761 gagaacgagt aaaaggattt gctgagtatc gttacacatt ctataaaaca agatacttgc 518821 cagacggtcg aatgactagc ttaaaagttt atatggagaa tcaaagcata aaaagggtgt 518881 tacatcgtgt agcatccttt ttatctttct tggaaagaac gaaacaaatt gaacagaagg 518941 agtgtgaaaa agttgctcaa taaagaaatt ggctctgata agaaggaaga atcctttttt 519001 cggtctgctt ttcaaaaact gaaacgaatt gaaagaccgg aaaaagacaa acaaaaagta 519061 ccccgtgaca ggtcaaagct gatagccgtc acactatggt cttgtgtagg gagcttgcta 519121 tttatctgtc tgcttgctgt gcttctgtca attaatactc gctcccaact taatgacatg 519181 aaagacgaaa cgaataagcc aacaaatgac gataaacaaa aaatttcggt gactgctgcc 519241 gaaaactttc tgtcagggtt catcaatgaa tatatgaatg tgaagaacga tcaagaatct 519301 attgaaaaac gtatgcagag ccttgaaagc tatatggtta aacaggaaga taaccatttt 519361 gaagatgaag aacgcttcaa tgtggatggt ttaaaaggtg atcgagagtt aaagggttac 519421 agcttatata acgtgaaaga aggtgataaa aacagccttt ttcaatataa ggtcacatat 519481 gaaaatctat accctgtaga aaaggaagtt gaaaaagaag ttaaagacgg aaagaagaaa 519541 aagaaggtga aagaaaaggt taaaacaaac gagaaatacg aaaaacaaat gttgctgaat 519601 attccagtca caaataaagg tgattccttt gcggtgtctg ctgtccctta ttttacacag 519661 atttatgatc tgaaaggcga tattgctttt aagggtaaag aagaaactag agacgaatat 519721 gcaggcgaga aaaaagaatc tatcgaatca tttcttcaaa atttctttga gaaatacgct 519781 tctgaaaaga aagaagaaat ggtttatatg atgaaaaagc cggaagcatt ggaaggaaac 519841 ttgttatttg gggaagtgca gtcagtgaaa atcttcgaga cgaaaaaagg tttcgaggtt 519901 ttttgtgctg ttcgatttaa ggaaaaagaa aatgacattc cggtaaatga aaaattcagt 519961 ctagagatta cggaaaacag cggtcagttt tatgtaaata aactcaaaca tcaataggag 520021 gtttaaatat ggatttcatg aatttcttta ttcttggcgc agaccttcca acacttggag 520081 gggtaaaagg ttgggcatca gatgttgtta tccaattcat tacgattgtg gtcatgttca 520141 tagccgcaaa gaatctgatg aaattaaaaa tgggcggcat tatctttgtt tgctgtattg 520201 gcagtgcggt aacgtgggtt attaaacact ggtcagaatt ctccggctgg atcaatgcgc 520261 taatggaaaa attgtaaggg ggcatctgaa tggggcgtct ggtgttcaac taccggaagg 520321 caatgagaga gccgaaaaaa atccaacaat taaccgaaaa ttattcgtta ccctttgcag 520381 ttgagttaat accggctatt aactatttca tttttgttgg cttatgcttt ggattctggt 520441 acggcgtgag gatgattttc cctcacgctt ttgataacag ttacgtcatt gtgatttttg 520501 ggataccatt ttttttaacg atgcttgtaa cgaaaataaa gccggaaggc aaaaacatct 520561 atatatattt ctttgatttc gcaaagtatt acttcttcat caagcttcca caaaagaagt 520621 attgcaatga tcgaaagatt gatttaagta acgaaaaaca aattgagttt cgaaaacttg 520681 tgaaggtggt ggattattca aatgagacta aaaacgccta tgaaggcaat acacaagaat 520741 ttgctgttaa caagaacggg cgacgtgtgg gcgtactacc gaataaaaag caattcgatt 520801 cctatgcaaa ataaagaaaa agttgaatcg tataaaaaga agtggcagca tctttttgaa 520861 gaaattacat cttatgagga ttttcacttg atgatgtatc caagtgagta tgaattagaa 520921 aaacgattta aggatttaga aacagatatt gcggcagatg caatggatgt ggcacgttac 520981 tacaatgaag aaaccgtaag gctgttagaa cagcgattag gaaggctgac aaagtacgac 521041 ttcattttag gtgtaaaact gaaaagcagt cttgtaaata ttagtgtcga acttaaagac 521101 aatatactat cttttttcaa tacagcgact gatacagtcg tgaaaatgct cgggtgggaa 521161 caaaatgttt ccacctcttt ttttgaaaaa tatgaggaag tcgaagaaac actagcgaat 521221 atcatggctt ctgttcgcgg agaacggctt tcagaaacag aaatgacata cattaaccgt 521281 tatcactttg tacgtgggtt aaagcaccaa acgaatgaag aaagtgagat aaaggatgtt 521341 cgctctatta caaacacgat catagacccc actgacccat cagtattgca tttgcatagt 521401 gatcaagatg aaggctattc agcttttgtc gtgattgacg aatttcttca caatatgtcg 521461 gaaagtgatt tgttttatga agcacagtct cttcccttcc ctgttgaagt tcagatgaaa 521521 attcaaacgg aatcaaagtc cattaccaag cctgccctca acctcaaaag acagcaattg 521581 aaagaagaac aaaaagaaca acaaagcaca ggcgatcgaa gtgatgtttc cactgtcaca 521641 agtgccacaa tgataaggca tttacaagat gaaataaaga aagaagatgt gcatgtgatg 521701 aactggctgt cggtgatagt cgttcatgga aagacaaaaa aagaatgtgt gggaaaagca 521761 acgattgtca aaaggcattt aaaaggcgct ggcattactt gtcggcttcc ggtggctgat 521821 caattgaacc ttttttataa aatgcttcct ggtgaaaagt tagacataac cgataagaac 521881 tggattcaaa aaacaacgca agacggtgtg gctgaaagtc tgtttgctgt taactctgat 521941 attggttcga aaatcgggtt ctttctcggt tgggttgatc gtttccaaga gcacaccgac 522001 ttagaaagtg ccattatgtc cagccgtgat tttgtcttat tccacccttt cttagcgaat 522061 cagcagttaa aaggttcaaa gacacgttct cctcactgct taatcacagg agacacagga 522121 aacggcaagt catatctagc gaaattgatc tttaactata tcagcatgtt aaacatcaaa 522181 tctctgtata tagaccctaa aaaggaaatg agaaagtgga ttcaaagagt cttgaatgat 522241 gagtacatta gagagaactt tcccttatat attgcacatt tagagaaata caactatatc 522301 acgctagatc atgaaaacac gcacaactgg ggagcgcttg accctatctc cttcctccct 522361 cctatgaaag caaaagagct agttcaagtc atttttgaac aagtatatga ctttaaaggg 522421 aaggacgaca taaacacagc tttccttcgt gctacgtcag aagtgattga tgcgaaacaa 522481 aaaggtgaac aggtcggctc acttgatatt attcggaaga tgcagagcca tcccgaagaa 522541 gctgtacaaa aagctggtga ctatttaaat gaggtcgtgt cagattccat tttgaaactt 522601 tgtattcatg atggttcaaa tcctgcattg tcactagaaa agcgaattac cattttagaa 522661 gttgaaaata tggatttgcc ggatcatgct gagcgacttg aaaactacac gatatcacaa 522721 ctaaagtcta gtgcggtcat gtttgcacta ggtaagttct gcgagctatt cggcatgaat 522781 caagacgaac agactgttga atttatagat gaagcttgga tattcaccac gtcacaacaa 522841 ggaaaaaaag tagaaagaca aatgcgccgg attggtcgct catacaacaa tgcggaatac 522901 ttcatttctc aatccacaaa agacgcttta aaagaagagg attctggaaa ctttggcgtt 522961 gcctttgctt ttgacgaacc aaacgagcgt gaagaagtgt tgaaatggat gaacatggag 523021 gtcacaaaag ataacaaaaa aatgatggaa tccatgtttc aaggtcaatg cttatttaaa 523081 gattactatg gccgcacctc taaaatttcg attgaatgcc tattcgaaga atggcaaggt 523141 gctctgaaaa cagttgagaa aaaagccgtc gcatatgcgg aagaaaaata tttgtaaaaa 523201 ggggttgaat cgtacatgga aatagctttc ttaaactctc ttgttgtcac gagtccaggc 523261 ttttataaag ctgagaaaat cacattggac gaagttaaac aatggctgaa gcattatgat 523321 ggtcgataca aaagttttat cggacataaa tcaacggcac agtttctgca aaaattatta 523381 ggtatcagaa ttgagcaaaa tcgaaagact ttcagacata tgaaatatca aaaagcaatc 523441 tgtttctctc tgtatgaacg atatcctgaa aacgtgttgc taacgcaaag agacttagag 523501 aaagccagat accaatttta tttattaact cggttagatt aggaggtggt tgtaatgaaa 523561 aagaaaagaa ttttgattgt gtcggctatt gtgttgctgt ttttaactgt tgcttcagct 523621 gtaacggtat tttcggctga tggagataca acgacgcagc caaaagtcga aaaagctggc 523681 ggcgtggaat tgaaggtgaa aaggtttcca atctcacgct atcaagcgaa taatgaagca 523741 tctgacgatt taatcaaggg ggcgtttgtt gggctgacaa acgtcacttt ttcttttgcg 523801 ggaaacattg tccgtgtggt tgatacgggg atggatattt tgtataactt gcaaccgatt 523861 gacgagttcg caaattctat tacaaacgtc tctaaaacag tttataaaac actgaaaaag 523921 aatttcggtg aagctttatt tattttcacg tgcgcctatg ttgtctacct attctgtgtg 523981 agaggtagcg taaaagaagc aatgcggcgg agtattctat ttatttgtgt catggtgatc 524041 ggtgggcttt ggatgtcgaa cgctggttat tacatgaaag tattgaatgc cttgtctgta 524101 gaagctcaag gaaagctttt aactgcgggg aatggattgg ttggcattgt tcaagatgaa 524161 ggcaattttg cagacagttc agcgattgaa aaaggaaaag aaatggaagg cacagttgcg 524221 gttatgcgta atctttactt tgacattgct ttgatgaagc cttttttaat tgtgaatttt 524281 gatgaaacaa gcgaaaagaa aatcaatgag gaagatacag ataaaggcgg acttaatcgt 524341 atagataaac tgctttctta taagctttca gaggatggag aaaaagataa aaaagattat 524401 ataaaagaga ctgaaattga tgattataaa aatgaatcta tgacttctgg aaatgtgttt 524461 aatcagctgg gagagtcttt tatcgctgtg gtcgcttcta ttgtcattgg gataccattt 524521 ttagcattag cgttctttaa tttcttgctt caagttgtcg ctttagtgat agttttcttt 524581 gtgccatttg ctttcatctt agcgtatgtt cctcaattag cttattcggg atttgttacg 524641 cttggacgct tggggagtgt ttacctactg aaagcaatgt taggggttat cgttctgttt 524701 gtgtacgtga cttgttttat tgttgacaag ttaataccgc caaatggttt tggaatgtat 524761 cttttaaatg ttgctgtcct tgcttcaatc ttgtggattg gttttcacaa gagggatgcc 524821 attatcaagt ttgtgactgc tggaaaagtt gtttcagttg ataataatat gatggaaaac 524881 atgagacaaa acattgttca gcctgcttgg gaacaagcga agaaaatagg tggagtatgg 524941 ggtaacggag gcggcgtatt tactgacttt acaaagcatt ttgggggaag aaaagacggt 525001 tcgaatgctg atggcgtaac tggtgctcca agtggtggcg gtaattcacc gagtgggact 525061 gctatgggat atgataatac tcatgctatt tcaagaaccc cgcaaaaaga aacagctaac 525121 ggaatagcta atcataacag tcgaagctta aaacgcaatc ctcaaactct atcgaaagaa 525181 caagaaaagc aaaaacaaaa agaagccttt gcaaatgcaa aagaaaataa acagcaatcc 525241 catttagcca gattgagaaa agacggaata aactctccta tgttgaaaga tgctttgaat 525301 gaagggaatg aggatttatc caaacgagca cctatcttgc aggataaaaa agatgaatca 525361 gcacgaacag atcaaaaaga atatgtggaa cagcttctta aacagcccaa taaccagcaa 525421 caaactgacg atgcatcatt acagcatgaa gaagaatcta cttctaatcg tgcgcctgtc 525481 ttacaagaga atgaaaaaga tacagaacgt actgatcaga aagcgtatat ttatgacgaa 525541 caaaatcaga atcttgaaac agatcagcaa caagattttg aagtccagaa agatgattct 525601 gtttccaata gtgagcctgt agcacaagag aaaacagcag aaatcaaacg atcagatcaa 525661 aaagtcatga tgaatcaacc tgaaccgcag ctcggttttg aaagtcctca atctacaaaa 525721 gtagaaaatc aacctattgc caataacgaa cgtaaaatca gaccatctga acccgcaaaa 525781 gttcattcag atggtattcg tgttgatgaa aaacaggctg ttgctcctgc tgaaaataag 525841 actgtatcaa gagaaaaaca gccttcatca caaacaatta aacggactga acaaagcgtt 525901 aattcatttg accaagtgtc tttgaatgaa attgcaagac gctcttcatc aaaagtagaa 525961 gatcgactga gaagggatga aagaacaaga tgataagtaa aaaggtagtt cttcctttgg 526021 tattctcggc tccttttatc ttcttttttg ttttatgtat cgtagtggtt atgacgattt 526081 caagagaaaa tcaagtcggg gacgatttta taggcggcgg ggatggcgaa tatgaaacag 526141 ttggaattgc gccggaagtg gaacgattta gagcagtatt tgagaaatat gcccgtcaag 526201 aaggcgtttt tgaccaagtg aatattatta tggcgctcac catgcaagaa agtggtgggc 526261 gttctttaga tatcatgcaa agttccgaaa gtatcggctt acctcccaac tccataactg 526321 acccagaacg ttcaattgaa gtcggcatta aacattttaa gaaggttttt aaacaggctg 526381 gcggtgatgt tcgtttaacc ttacaggcat acaactttgg ttctggattt atagactatg 526441 tcaaaaagaa tggcgggaaa tacacaaaga aattagcact tgatttcagc cgattgcaag 526501 cttttaaaat gggctggaaa agctacggtg acccaagtta tgttgaccat gtcatgaggt 526561 atgtgaaagg ctctgataaa aatgtgaagc ctgtgaaagg ctctatggat ttctatgaaa 526621 cggtcatgaa agaagctttg aaatatgaag ggcaaccgta tgcctgggga ggttcaaacc 526681 cggaaactgg atttgattgt tctggccttg ttcagtggtc ttttgcgaaa gctggaatca 526741 ctcttcctag aacagcacaa gaacaacatg gggcaaccaa gaaaataagt gaaaaagaag 526801 cgactgcggg tgacttagtg ttctttggcg gcacatacga aggaaaagcc attactcacg 526861 tcggcatcta tgtaggcaat ggcagaatgt ttaattcaaa tgacagtgga atccaatatt 526921 ctgatctgaa atcaggttac tggagagatc accttgtatc ttttggacgc attaaataac 526981 taggagtgaa aatatgaaaa cacatattgc atgggcttca gcttgtttat tattagtcat 527041 gttaactgga tttttcacga ttggacagca aacgtataag attgaaaagt taaaagataa 527101 aaatgaagtt ttgagcgaaa aaattaagga attgaaccat atagaatcaa caagtagcgc 527161 ttcggaaaat aaggcatttt ttgaagcgtt ttttaattac tccgacatag atatacgata 527221 tgaaacagtt aagaagcaca caactggaaa agggtttgat tatgcattcc cttctcgttc 527281 tgatcaaaag cacacagtca gcgtgcaaag tgaattacta tcactagaga gttattcaaa 527341 gccgttagat gagtctcatg aattgttttt aaacattgtt gaagtcgcca caactgcaaa 527401 ttcagtcact acgaatcaag tgttaattgt acaaacgact atgaaaaaag aaaaggatgg 527461 ttggttagtc gataatgtgc aggttaaggg aaatggataa aaggtggaaa agatcaattt 527521 gtttgtttat actaaatatt gaaaaaggag gtaatgttta ttttgaaaaa cctttttatt 527581 ttccttagtt tgatgatgat gtttgtttta actgcatgtg gtggaagcaa gtatgatgat 527641 gcgattgatg atgtaattag ccaatataaa gagcataaag gaaatgacac agagataaat 527701 attaaaagag agaatgcgat tgttagagtc tatgaagggg gcaaatatat tcagtttgca 527761 ttttatatgc cggataactc ttcacgtgaa ttaacaacat ttaagtatta tgaaaaattt 527821 ggagataaat atgaaaagat gactgatatg ccggggaatg gggaaaatga tcgtctgggg 527881 ttatcaaaga aaacaccaga ctatgaagaa gtaaaaggag aagagacaga gttagaggag 527941 taaaccgtgt gtttactcct cttttagttt tattgacatt ggtaaaacag agatagggta 528001 agaacttagc taattaagaa tgaaaattat aaggtttata agttggaaac taaatcaaat 528061 atgtcttcta agaatagatt tatgggtaaa agttgttttt acactattgg tgctactagc 528121 agtggcattt aagttatttt aatttcgtat taaatttagc ctttatcctt tcccattttt 528181 tatcttctaa tgtgagatca tacatacgga gtattttttc ttttaaatta aataagtcta 528241 ttggttcctc caaggagaat gcttttttat ttttatcaat tactcctttt atttcgccct 528301 taaaaccagg gaggatgaaa gtagagcagt tattgctatt cacccaagta gcccccattt 528361 cattaaggca gtatacgcta tcatagtaat tatcggataa catataaaag acatatgcac 528421 ccttaaaaag atgttttttt agatattcga aaatatcttc atctccagga ataccatgat 528481 aaggtgaaga agtgtatatt atatcttcag aagacactcc tatatcctct agtaattcaa 528541 cgaaagcatt acatacaatt ttgtcttttg aggagtggct aataaatatt tttttctcta 528601 attctctatt ttgatcactt gaaaagtgag ttatgctgct tttttcagtc tcatctacta 528661 caggcaattc atctaaaaat ttttttattt tattttctgt ttcatgatgt tcaaactcat 528721 taaaaacaaa ttcattttta tatatttcat tgcggtttcg tgcataccaa gtcttaagtt 528781 gttctagtga ataacgaatt aactcaatat catttgattc aagagatgtt cgaaattgat 528841 caataatatt tgtgagtaca ggctcgcgag agtaatctag aagtactcct ataattccat 528901 tagcctcaaa ttttaatttt tttaatgtgt ccattagatt tcctccgacc taatttaatc 528961 cattgtttgt aaacatttca tatctaatta tataacatag actcctattc taactactta 529021 ttttaaagca gtctggattg tttgggtaat tcataaaaaa ataaaagaaa gaaggaggaa 529081 tagagttttt cttttttttg tttgcaatgt tactgtcaag tcgcaaaaga attgctatga 529141 ccgaaaaaaa accgcaaagg aatagatata aggtaccttt ttgcaattca tctttgtaaa 529201 ataaaggtta ttctgacata atacaattaa tgtaaaaatt cgcacaattt tatgtaagga 529261 tgggggaatt ttcttgcggg gtgttttctt agataaagat aaaattccgt acgacttagt 529321 cacgaaaaag ttaaatgaat ggtatacatc aataaaaaat gatcaagttg agcaagccga 529381 gattataaaa acagaagtag agaaagaatt gttaaacatg gaagaaaatc aagatgccct 529441 gttatattat caactattag aatttagaca tgagataatg ctgagttata tgaaatctaa 529501 ggaaatagaa gatctcaata atgcttatga gactataaaa gaaattgaga agcaagggca 529561 attaactggc atgttggaat actattttta cttttttaag ggtatgtacg agtttaggcg 529621 taaagaatta atttcagcga taagtgctta tcgaatagct gaatcaaagt tgtcagaagt 529681 tgaggatgaa atagagaaag cagagttttt tttcaaagtg tcctatgtat attattatat 529741 gaaacaaaca tacttctcca tgaattatgc aaatcgtgca ctcaaaatat ttagagagta 529801 tgaagaatat gctgtccaga ctgtgcgttg tcaatttatt gtagcaggaa acttgatcga 529861 ttcattggaa tatgaaagag ccttggaaca atttttgaag tctttggaaa tttccaagga 529921 aagtaacata gagcatttaa ttgcaatgtc acatatgaat attgggattt gttatgatga 529981 attgaaagaa tataagaagg cttcacaaca tttaatttta gcgttagaaa tttttgaaaa 530041 atcaaaacat agtttcttaa caaagacttt attcactcta acctatgtag aagcaaaaca 530101 acaaaattat aatgttgctt tgatatactt taggaaaggg cgatttattg ccgataaaag 530161 tgatgataag gaatactcag cgaaattcaa aatattagag ggattatttt tttctgatgg 530221 tgagactcaa ttaataaaga atgcattttc atatctggct tcgagaaaaa tgtttgctga 530281 tgttgaaaat ttttcgattg aagtcgctga ttattttcat gaacaaggaa atttaatgct 530341 ctctaatgaa tattatcgta tgagtattga agcaagacga aaaattaaaa aaggggagat 530401 tattgatgaa aatcagccgg attctattgg cagcagtgat tttaagtagt gtattttcaa 530461 taacttattt gcaaagtgat cataatactg aaattaaagt tgctgcagat cgggtagggg 530521 catagcttag ataattggaa aagaggaaaa aagcttaatc ttttttcgaa ggttaagctt 530581 tttcttttat ttataaaaag tgaactaact atcagaaaga aattatatta aattttattt 530641 ttttgtttaa aaagtagatt atataaaggc aagctaggtg ggggaaaata tgtttaaaaa 530701 agaaaaagtc acagaataca tttggactat actaatacca acaatcatca cttttatcat 530761 tagttgggtt gggtcttatt acaatggtac ttcgacagtt agtattggac aacctacaaa 530821 agtttccggt cagtatatca cgccaataaa tataagtccc tatcatgata ttaaggaatt 530881 aagaataact tttccgcaaa aactagatgt aaaacaaatt agttcaaatg agcctataaa 530941 tgtaaaatca gataagaaca atataggagt tgaaagtaat tccacttttg agattgcgaa 531001 aatcgttgaa aataatagcg ttcagttgct aattacaaca caaaaaaagt taaacgataa 531061 ggaaattaga attgataaaa atggaaataa catttctgta aattatgaat ctcagattgt 531121 taatcctgca aaaaaacaat taatcaatct tataattacg tcatctattt attttataat 531181 gcttaatata ctagcattga ttatgaacaa aagatgggat aagtattatg caaaaatgaa 531241 aaatgaaatc aaagaatttg aggataatgc aaaagatctt gataaaaaat caaagaagaa 531301 aagcgaggaa ttatcggagc tgcgaaagac cttgaaccaa gcgtttgagg aaactgatag 531361 gataaaatat catgagaaga aaaaacaaat cctcctctta gctaagttaa acgattataa 531421 aaaagaacta accttttgga gaaatacaat aagaaaagtt ctttatgaac ttcctgatgg 531481 agataaaaaa gcagataaac taatagggac agttacatca tctttaaaaa cgtacggtac 531541 agtcgaaaaa aacgagcatg attatgaaag tttaaaagta gcagctgcct tactaaatga 531601 ttctgataag agatcgtaat gtactggatt ttaataaact attagaaaga agattagctg 531661 caaacatcag aacgaccaaa caatggtggt atgtttatag agtttagttg ttgaaaaggg 531721 cgaactatga gtttgctgcc catttactgc ccagaataaa taacaaatca tgaaaatcag 531781 tgtaaataaa ataacttaat gctataaata aaggcttttg taaataaaga tatgatttta 531841 ctaggttgag ggcctagtgg gtgaataacc cgtggaggtt caagtcctct cggccgcatc 531901 tcaataatac caagggttta accacctttg gtattatttt tttgtgtgga aaatacggct 531961 atgggagaag acttgctcac caaaactcac cagttactta aagtaagtca tccaaacggt 532021 cggcggttcc ttctgtttat taggaaaaag atatccgttc attgtaaaag aaacgaacca 532081 tgtcctattc gttcaaaaaa actaaagggt gatacatatt atacatgatt aatatgtatc 532141 acccttttct ttcttgttca acaatcgcgc ttgaggagaa cataagctaa tacaactgac 532201 tcgatttcta aagttgctcc attctttttt taaacaactc atccacaacc tgttttaaaa 532261 tctcgtacga ctgaatttcc ttgctcaatt cgtaaatatt agataacaca attaattcat 532321 ctgcgtgata catttgttgg aaatcaatta gttcgcgacg aattgtttct cgatcaccca 532381 tgattgtata ccccagtcga ctgtggagaa tttctaattc aaactgtgat aacgattcta 532441 ggaagttttc agtgggtgga ataagcttac ttaaattatt tgtataaata tcaatataca 532501 cctgcaaatg acttgcagaa ataaaagatg cctcgtctat agattctgct gcaatcacat 532561 taatgcaagc gatcacataa ggttcttgta aataagaaga cggttggaaa ttttctcgat 532621 aaatagagag cgcttcttcc atcgaatggg gtgaaaattg agcgccaaat gcatagggta 532681 aaccaagctt tgcagcaatt tccgctgaat ccgttgagga tcctaacaca aaaacaggca 532741 catgcgttcc aatacccgga taagcgcgaa cctcaccctg tacactctta tccccgacaa 532801 aacgcaaaat atcatttact tctctttcaa agaaaaacac tccattatgg ttggaacgac 532861 gaatcacatc ggccgttttt tgatccgttc cgggtgcgcg tcctaatgcc aaatctacac 532921 gatttggata taatgtttca agtgttccaa attgctccgc tacgattaat ggggaatgat 532981 ttggcaacat aataccccct gaacctacgc gaatgtcttt tgtatttgct aatatatgtt 533041 gtacaattga tacggttgct gcacttgcat aagcgtcgtg attatgatgc tctgcaaacc 533101 aaatccgttt atagcccata ttatctacag ctttagctaa tgacactgca gaatcaatcc 533161 cttgtttcat tgtttctcct tgtcttaatg gagcaactga taaaacagat atatcaaatt 533221 ttttcataat ttcacctcta aaataatgaa cttatacaag atcaatggaa aaaacatttt 533281 gaaaaattgt ttcatattaa atggtgtcca ttcctctttg atttgcatgc aaataaatat 533341 atactttctc aaacgatcaa tacataggca aaataaagtt atttcacaat ttcactttac 533401 ttttaaagtt ttaagcaaac ataaaaaaat gttcagtgaa caaaatatgt aaaatacatc 533461 ttatttttca gaaaggatac aagaaaatga ttgatgaaat agataaaaaa atacttgatg 533521 agctgtctaa aaatagtcgc cttacaatga aaaaattagg ggaaaaagta catctcactg 533581 caccagcaac cgcatcaaga gtagtaaagt taatagacaa tggcataata aaaggatgta 533641 gtatcgaagt gaatcaagtg aaattaggct tctctataca tgcttttctt aatatttata 533701 tcgaaaaaat ccatcatcaa ccctatttag cttttataga aacacaagat aactatgtaa 533761 taaacaatta taaagttagt ggagacggtt gctatttgct tgaatgtaaa tttccttcaa 533821 acgaggtatt agatcaattt ttaaatgact taaataaaca tgcaaactat aaagtgtcga 533881 ttgttattgg taaatagtta actttataaa acggagatgt gcggtcatat aacatgatat 533941 atatgctcta aaaaagccct aggttggata tggaatttac caagctgggg cctttttata 534001 cattataata acaagcgcat tattcatcag acattaatga agtattataa tgctttttta 534061 cttccttaat agacaaataa agctgatagt ttccatactt caataaatca ttcagaaggt 534121 gatttaaaac ttcttgtgaa tgaaccgtta ccttcagaag ataacatgca tctcccgaaa 534181 cacgatgagc ttcgctaatt tcattacgag tagcaataaa tttcaataaa tcatcatgca 534241 tatatgcatt catgaaaaag aagacaaagg ctgtaaaaga aaaccccatc ttcaattcat 534301 caaccacaat cgaatatgct ttaatgatac cgttatcctc catttttttg atgcgattgc 534361 ctaccgcttg tcctgtcata tgaatttttt caccgatttc tttccattgt atccgagcat 534421 ttttatttaa taattggaga atttgaaaat caattgaatc aatttgcata gtaactcctt 534481 tcacagtgaa aaagttttac aaaatagtat ttcatgagac catcgaaaat tcaatggaaa 534541 ttatatatcc ttatacagta taaaaatttt aagaggtgaa aaaatgacaa cagctttatt 534601 agtgattgat attcaaaatg attactttcc aaatgggaag atggctttaa caaacccaga 534661 gaaagcagca caaaatgcgg ctaaactact ttcacacttt agaaacacag gcgcacctgt 534721 ctttcatgta cagcatatca cagaaggtaa catcgctcat tttttccatc caaatacaga 534781 aggtgtcgaa attcatgagt cagtacgtcc attagagaaa gagacagtca ttgtaaaaca 534841 tatgccgaat agctttttca atacagattt aaatggaaag ctacaagaag aaggggttaa 534901 agaattagtt gtttgcggta tgatgtccca tatgtgtatt gatgcaacag ttcgttctgc 534961 agttgaacat ggttatgtat gccaagtggt agaagatgct tgcgcaacaa caacattgca 535021 aattgaagat aaaatcgttc ctgctgagca tgtccattac gcatttatgg ccgcattaaa 535081 tggtgtctat gcaacagtaa aaaccacaga ggcattttta aaataaaaga atttcctgcg 535141 cgaacataac gtctttcttt tcacaagaaa gatgattcaa caacttaaaa aaggatgttc 535201 agaaaaatac ttctggacat cctttattca ttatctttta ttgtttttca gtatcattat 535261 tcccatctga taaaagatca agatgtcctg tttttgatcc atagtaagac catatacagg 535321 gattgttttt gccataaata tagatattga tgaaggttta cataaagcac ctaattgctt 535381 gatttacttt aatgttagat ccctcaataa ctccattctc ttctaatttc tctactctag 535441 ctgtagctgc tgggcatgtt aaatgtactc tctcccagat ctttcattga attcggctat 535501 tatacataat ttctctataa ttttttatct gtttgatcta tttgaacgtt aattcctttc 535561 gaaaataaag tcaaagagtt aaaacacttt tttttatcta tgtattcgaa cactgctgat 535621 attatacact taactctgtc gatctaagac aaataaaaaa agaaagtgag ttgtaaatat 535681 gaatattaca caaattcgaa atgcaacaat tgttgtaaaa tacgcaaata aaaaattttt 535741 gatagatcct atgttagcag agaaaggtac gtacgctact ttccctgaaa cgatcagaca 535801 agatttattt aatcctttgg tgagtttgcc aacatcaatt gataacattc tggatggcgt 535861 agatgcggta attgttactc atctacacct agatcacttt gatgatgtgg caaaaaacgt 535921 attgccaaaa aacatcaaaa tgtttgttca aaatgaagca gatgcaaaag aagtaaaagc 535981 aagtggtttc aaaaatgtag aagtgctaca tcaagacact gtttttgaag ggatccaatt 536041 agtaaaaaca aaaggtgaac atggcagagg ggaagagtta ttaaacttaa tgggtgatgt 536101 ttgtggatta gtattcaagc acccaagtga aaaagtttta tatgtagctg gggatacagt 536161 ttggtatgat gctatcgaag acgagattca tacacatcaa ccagaaatca ttgtggttaa 536221 tggtggagac aatcaaagat tagatttagg ttcactcatc atgggaaaag aagacatcta 536281 tgaagttcac aaggctgctc ctcatgctaa gattatatct gttcatatgg aagctgttaa 536341 ccattggaca ctatctagag aagaattaaa aaactttagt aaagaaaaag gattctcaag 536401 taatatttta gtgccagaag atggcgagtc ttacacattt taatatgaac accgacaaat 536461 aaatagaaga agctcataat tataaaaact aatcatgagc ttcttctaat aatgaatatt 536521 ttaaatttta aatatatcga aaatcctaaa tatacggaat aacaaaaatg gaatgttcca 536581 atgatgacaa aaaaacttga aaagcaacaa agatgtgtcg ttaggaggta gaattcatgg 536641 taatgacaaa aaaagataca aatatatcaa cacagcagcc tctttggtta caaggttata 536701 ttgattcacc agaaaaacaa aaccaacttt ataaaaaaac attaaaaatc ttgatttttt 536761 cacaaatatt tgggggagca ggacttggag ctgggataac agttggggcg cttcttgcac 536821 aagatatgat aggatcggaa aatgtagcag gaattccaac tgccctcttt acttttggat 536881 ctgccgtagc tgccctgctt ataggagcat cctcacaacg ttttggtcgc agagctggac 536941 ttgcaggtgg tttccttata ggcggattag gtgctatagg tgtgataatc gcggctttaa 537001 ttaacagcgt tgccctatta tttgtttctc ttcttattta tggagcaggt atggcttcta 537061 atcttcaagt tcggtatgct gggacagacc ttgcaaatga gaaacaacgg gcaactgctg 537121 caagtatggc cttagtttct actactttag gagctgtagt aggtcctaac ttagttaata 537181 caatggggga atttgcagat tcaattggtg ttcccaattt agctggtccg tttattatgt 537241 caggagcagc ttttataatt gctggaatta ttctcttaat ttttcttcgt ccagatccgc 537301 tgtttgtatc aacagctatt gcgaatgctg agaaaaaaga cgataaagta caaataggag 537361 gaagtctaaa aaatcctgct atagacaaaa aaggaataat ggtaggagct gtcattatga 537421 ttttagctca actaatcatg acagctatta tgacaatgac accggttcac atgggtcatc 537481 acggtcatgg tttaagcgaa gtgggattag ttataggact ccatattgca gcgatgtatc 537541 ttccttcacc attgactggt ttattagtag ataagtttgg tcgcacaact atggctattg 537601 cttcaggtgc cacacttctt gccgctgggt tggtggcagc tattgcaccg gcagactcat 537661 tatcattgct aatcctagca ctagtattac taggggtagg ttggaacttt ggtttactaa 537721 cgggaactgc ccttattata gattcaacac atccatctct acgtgcaaaa acacagggaa 537781 cattcgatgt tttattagca ctatcaggag cagcaggtgg agccttgtca ggaatggttg 537841 ttgcacattc tagttataca atactatcaa tttctggagc cgttttatca ttgttactca 537901 ttccagtagt tatttggtat tttagaagga ttcaggaaaa agcataagct tatataactg 537961 tctttgaaga acctaagtag acattacttt accggaacct cctttttcta tttattatag 538021 taaggagttg acatggcatt agtggcatgt gtataactac acaattattt gggattcaga 538081 gagcatgtaa tgaacggaag agataattat ttatcacttt tattattgta cggtgttctt 538141 gtggcattaa gttcagtcaa ttttggtcta actgttttct ttttgttttc atcacctctc 538201 catattatta acaaacacga aaaggatttt aatgaaaata aaatgattag cgtatgtatc 538261 tctaattttc aaaatgaatg aatagtcctt tttaagattt acacacttat tctccaagga 538321 aaaatgactc aatttttcga ttttttatgt aaatcaaaaa agaatcatgt tagagtaggt 538381 gtgctgaaaa taattcaaaa aattattttg cgatatgatt aaagtaatat tgccagagag 538441 tttcaattgg acaaaattgt aagtgtttaa tacactgggg ctgcaatcaa atatgcacct 538501 ggaatcaatt gctaaacggg ggagtttata tgaacaacaa gaaaaatatc tttgatattg 538561 ttatgtacat tattttcggt gtgttaagtc tttttctagt tgcaaaaact gattatggca 538621 ctggagtttt agtgtttgtt gcaattttat acctcgctgt tattgcttat aaaattaagc 538681 aagtatttag taattcagat tcttaaggtg taacacaagg aggatttcaa ttgagaaaga 538741 aaagagttat tacttgtgtt atggctgcat cattgacttt aggctcactt ttacctgcag 538801 gttacgcttc tgcaaaggag gactctaaga caaccccttc ttacgaagaa ctagctctac 538861 attacaaaat gaaaagtgaa aagatttcat cgaacgggaa attagttgaa attgagtatg 538921 tgagtggaaa tgaaactcac aaagttcaga tgaacggaaa taatcatact gtaaaagtcg 538981 atggcataga acaaaaaggt ttaaactttg agtatgatga aaatgttgct aaaagaacaa 539041 attatgaaaa caataatttg aaatcaaatg aattcacaac acaggctgca aaacctaaaa 539101 agggatacca ttatgtgggg actttatctg ggcatacaaa agcagctaaa aatgcgttat 539161 cagttacaat gtcattagtc ggtattgtcc ctggcttggg atgggggagt aaggctgcca 539221 ctattttatt ctcttattgg gcaaaagaac aaatccctga tgcgtattat aaatatgatt 539281 tatacgaaaa aggagcaatg actgatagtt ggtatcagta tgctacagtt caattttttg 539341 aagataaagc tcataaaaag aaaatgggca aaccttggac aagtactcct gcaaaagtag 539401 atttacctaa tagctaattt taaaatcact ttgtctttat aaaggacaaa gtgatttttt 539461 gttatacaga agtaaaatcc ctcgtctgag gaatcttgga aaaaacttgg ttcaattttg 539521 atataacatg tttttttctt gctaatttag tttttctatg tatcgctaca cattctaaat 539581 aataagatat tagccggacg gttgatgcca agctcaaaag tttatatgga agtcaaagca 539641 taaaaaaggg tgttacaacg tgtagtcttc tttttatttt gccaacgtaa caagtgtgaa 539701 agtaatgatt tgtaggatca gttaagaaag gtttaagatt agatattgaa aaattttata 539761 tattttcaat aaaatactgg tactataata aatgtataca gattgtatgg agatgtaatt 539821 aattaaaaag gagtttttaa ttgcgttgga gtaaatggtt caatgttttt tgtatagtag 539881 cattgggatc aatatatggt tataaattat ttactaacca agaagtcagt actactcgtt 539941 taataatagc ttctgtaatt gtgttgtgga atattgttgg actttttagc aaagaatcag 540001 taaaacaagc acagcaagca aattaaaagt cataaagttg ggaaagaagg atgttactta 540061 tgtagtatcc ttctttatta ttccttgaaa aatgaaacaa attggagatt acagcttata 540121 taatcaattg aagtcgttga ttattttcat gaacaggaga tttaatgctt tctgatgaaa 540181 tattatcgta tgaatgttgc aagaggaaac gttactcaaa gattacaggg atgtgatgaa 540241 cactcctctt tatcgcactc acctgacccc aaattgttgg ggaagggcag gtacggaaga 540301 tagagtattt tttcttcgta acaaatcgaa aaggttggat aataaaaaac ttataatcta 540361 aggcggtata tagttgtgaa aaaggcgtta tttcttatat tagaccagta tgcagattgg 540421 gaaggtgttt acttagcatc tgcattaaat caaagagaag attggtcggt tcacactgtt 540481 tctttagacc ctattgtaag ctcaataggt ggttttaaaa catctgtcga ttacataata 540541 gggttagaac ctgcaaattt taatttgcta gttatgattg gcggggattc ctggagtaat 540601 gacaataaaa aactattaca ttttgtaaaa actgcatttc aaaaaaacat tccaatagca 540661 gcgatatgcg gtgcagtgga ttttttggcg aagaatggtt tgctgaataa tcatagccat 540721 acaggtaatt ttgtttactt atggaaagat tacaaacaat ataaaccgat tagcagtttt 540781 gtagagaaac aagcagtaag agataaaaat ttggttactg ctaatggaac tgcccctatt 540841 gaatttacta atttaatttt agagatgatt gattttgata ctcctgagaa catagagaaa 540901 atgatgtata tgaatcgtta tggtttttat catttttgtg ataaatatgg aaatccattt 540961 gttgattaat ttgctggaaa tgattttccc gaataggggg ctttgcgatt gagttgaatt 541021 tcctaataaa gcaaagaaag atgatttgag gtcaagttta acaaataatg ccatcaatat 541081 taatttgcag ttatttccga ttcctgatat aataaagaag aattattttt gttcggtgta 541141 aaggatagta tgaagattga cttttcgtct tgatgatact ttgggcaagg atagtatata 541201 ctgtgtggtt acacactagg aggcaacaaa aatggaacaa ggtacagtta aatggtttaa 541261 tgcagaaaaa ggttttggct ttatcgaacg cgaaaatgga gacgatgtat tcgtacactt 541321 ttctgcaatc caaagtgacg gattcaaatc tttagacgaa ggtcaaaaag tatcgtttga 541381 cgttgagcaa ggtgctcgtg gagctcaagc tgctaacgtt caaaaagctt aatcttcaat 541441 cgtttataca aacaggctct ttatataggg cctgtttttt tatgtctata tcatactcaa 541501 taaaaaaccc tactcaacgt tcgagtaggg agatgctaca aggtaataga aaaagattta 541561 aaacttcaaa ggtttgttta cagtataaca tactggattg acaatatgcg gaatgtatat 541621 aaattattta atgttttgtt caaatataga taactgactc tttttttcac taacctgttc 541681 gttcatttaa gtaagattag atgaattata aaaatggttt catctaaatg ttatcaactc 541741 gcatatctct tttatgagaa gaagataaac aattattatt caatgttgca gtggatataa 541801 gaaattctta aaaataatga ggagatcgat tgtttttttc tcctggaaat aatcacttag 541861 agatacctaa aacaatgaaa gccctacctc tcttccatcc ttacggctcc ttgtccgtgc 541921 cagtgtgaat caggatacta aaaaaagtga ctattttatt gagttttttg gtaaaacttc 541981 aatcttcgca gaagaaatgt aaataataaa aatggattag aatgtaggaa taacaaaaga 542041 ggtcgttaat gttctaaaca taagttggag aagatttgct tttcatcata atattccgaa 542101 atatcttttg ggatgtatct aaccaaaact ttttatttgt ttttcagtga ttcctttaat 542161 tacttccagt tcactaatca aaaattcata tgcattatcc agcatttttt tttcgcttgc 542221 attaagtgct ttttctttct tcatacgcat taaatcacgt acaacttcag caccttcttg 542281 tatttcacct gtttttattt tgtccgtgtt tattttgtac ctttgcttcc atggcagtaa 542341 cctatcggat tctccatgct gaaaaatgtg cataatgtgt tttaatgcaa gtatatcggt 542401 aactggtcgt atattcgaac tcaatatttt actcgttgga atcataactg tcatattact 542461 gattgacatt cttatgacat aatactgttg tttttcctct aagaattctt tttcttctat 542521 ggcttcaatt atacctgctc cgtgcattgg ataaacaatg ttatcgccaa tttgaaacat 542581 atcatccacc tccatatatg gtatccttct taagattacc atatatggag gtgtaatatc 542641 aaaattttaa taataacatg atcgaatttt tgatgtcaat aacttttttg aaaaaacaga 542701 tcaagcaaaa acaataggga acgtgtcgga tttccaatca ggaaaaggtc aattgatccg 542761 tgtgagcagt ttttcattgg ctcaatgaca ttacagaaat gatttgagta gataagaaag 542821 aacgatattc gtgaaatgtc agctaaaaat atttaaagca catgattaag ttctaatttc 542881 tttaccgatt tgatatggat aacggccgac ttacttaatg atgcattttc acttatcttg 542941 caagcagaaa aaggtttgtt gataaacatt tagccaccaa attggcatta ttatcaggga 543001 aattgacaac cttcaaatgg gtattgaggc gagaagaaaa ataaagaaag gagagattat 543061 aaatgaagac cagaacataa agaagtaaag gggaaagaac aaggttaatt gaaaagcaaa 543121 ctatataaaa tagtttgctt ttttttgtta tgacttcact tctttttctt tctctttaat 543181 gactaataaa acaccgctca gaattaaaaa cgaacctatc caaaatgtcc cgcctatttg 543241 ttctccaagc agaatccatc cgagtaaggt tccaaccaga ggctgaaaaa agaaaaagag 543301 gcctccactt gaggcattta ataattgtaa gccgtggttc cacaataaaa atgcacaagc 543361 tgttgaaaca attcccaaat acaaaaggcc acctagaatt ttagggtcaa gcagtagtgg 543421 cgtaaaaatc gtgctagggg agtaccatta acagggactc catttattaa tagaataaac 543481 tttatgaatt catttttttg tatgataatg gcgtcatatt catcgcttgt tgaaatttac 543541 ttatgaaata actggtactg ttaaatccaa cttgataaga cacttctgtc acattggatt 543601 cagggtgttg cagtaataat aagctttttt gaattctata atccattaca taacgtaatg 543661 gcgtcttatt cagcattcgt ttaaaataac ggcagcattc agaacggctc agttggccag 543721 cttttgcaat gtcctctaat gtgatttttt caacataatg gagatggatc cagtttaaca 543781 tttgtttcat tcgatgactt tttatcattt cagattgatc gtactctaat tgaaaaccat 543841 taacgaccag gtttttccac attaacgtta attgcatcgt aatgtcaatc tcatagagcg 543901 atgtcttttg ttgaatcaat tgatttattt ttttaacagc atctagaata ttttttgccc 543961 actgttgatt tccagccaaa aataaatagg gcaaattggt tgaaaacata tagggctgaa 544021 catagcttga atacagttcc tgagataaaa cgaaatgggg tgacacattc aagcaaatat 544081 acgtacaatc cgagccttcc ttttcttcgg ccatgtgcag gtagccgcta ttgataaata 544141 atccatcccc ttcgtgaacc tctatttttt cttcatttat ttgaaagaga gctatccctt 544201 ttagtatcaa aacaaattgg atttcatcat gccaatgaag cggaatatag ccatttatat 544261 tttgattgat cgttgtcttg tagcaggcaa ctggcaattc taccgttcgg tgctctgtta 544321 attcttttaa attttgatcg atcacaaaat tcttcattct gacttcacac ctcaatatat 544381 ttatattttt tcattcaatt tgagtatttt ttatcatgtt ttgcatttat tataacacta 544441 ttattatatt tattagtgag gagtcatgta tgaatacttc caatagaaga atgggattgt 544501 tctatgttat cacaggggcg acatgttggg ggattggagg cacagtagcc aaaaaacttt 544561 ttcaagaata tcaaattgat gtcaattggc ttgtaacgac acgcttgctt acggctggaa 544621 tgttactttt aatgctgcaa ctgttcagaa aggatcgttc ccaggttatt gaggtgtgga 544681 aacacaaagc gtcggctggc cagcttctaa tttttggcct attgggaatg ctagctgtgc 544741 agtacacata tatggcatcc attcaacatg ggaatgctgc cgttgctacg ttattgcaat 544801 atttatcccc agtaatcgtc attatctaca cgctgttgcg aaaacaaacg gttcttacca 544861 aacaagatat cataactgtt gtacttgctt tagtgggttg cttttttttg ttaacaaatg 544921 gttcaatgtc tcaactttca gtgccggcag ctgcagtagt atggggagtt ttatcaggat 544981 tcgcggcagc tttttatact ttgtatgccg ttggtttatt aaataaattt gattctcttg 545041 tcgttgtagg ttgggctatg attattggcg gttttgcatt gggttttatc catccgccat 545101 ggcaactgga ttttcaacga ttaactgctg aggcgtatgc atatatctta ttcgtgatat 545161 tatttggaac aatgattgcg ttctggttct tcataaaaag cttggaaagc ctctctccaa 545221 aagaaacaag cctactaggc agtctagagc ctctatcagc tgttgtaaca actgtcgttt 545281 ggttaaaagc gccatttggt tcttttcaat ggattggtgc tatttgtatt atagggataa 545341 ctttaatatt ggctttacat aaagagcctt ctatggagag tgaaaaatcg atattaaaga 545401 ttaggaatca tgcaaatcgg gatatatagg ggcttttttt gcttacatga ccggtccggc 545461 aatgaaaaac actggtggag tttgagccct ctcggcagta tcaaaaatac caagggtttt 545521 gacgccctag gtattttttc ttcaagaacc ttcaattttt cttctctgat tgaaaaacgt 545581 attacttttt tgtgattggt atccaaattt cacttttaaa agatggtgat gttacatcct 545641 tatgctcgtt ccacaatatt tctggacctt ctatttgttc gtaatttgac gatggaaacc 545701 attcggaata aatgcgtccc catacttctt gcagtgtatc cggaaatggc ccgattgatt 545761 cgaatacagc ccatgttgag gcaggaactt caagccgtga gaagttatct ggacaccgtt 545821 tcgttgtggc tgcgccaata tagtgatcga gctctccgtt ttcctctgtc cgaccttcag 545881 aaaaattcgt ggatgcacta atgaggcctg atggtgctac attagatagc tcttttagtt 545941 tatttattgc tttttcatct aaactttccc acatagatgc aatttccgga ttaattcctt 546001 tgaaaataat aggaactctt tttttaatgc caacgatgcg aaatgcctct ttttcttcaa 546061 tacggtagtt catttcattt cctcctttaa ttgttagctg gaaggtcatt cgtggataag 546121 ctttaaggga atggccatta aatctggctt ttgatgggtt tatgccatgt aaattttgga 546181 atgcccgtgc aaaagaatct ggtgagttat aaccgtactt tattgcaata tcaatcactt 546241 ttacattgct gtctttcagt tcaaaagctg caagagtaag acgtctgcga cgaatatatt 546301 ccgataatga aatacctgca aggaaggaaa acatcctttt aaaatgatat tcagagcaga 546361 aagcaagctt tgctgcctct tgaaaatcaa tatcattagt gaggttttct tcaatatact 546421 ttaacgccct attcatactt ttaagcaaat ccatttattt ggcctccttt aaccaaagaa 546481 taacaggagt gaaatgtatt tatccgacat tctgtgcaca gttttgcagg atgacttata 546541 tgaaataaag taagtgattc acttgtattt gtacaggttt tattgaagca tgctgttcat 546601 aaaaaggcat caataaaaga aagttataat tgtcttataa acggcacatt catataattg 546661 agtgaaaaag gatgcgtatc atgcctatca attcttttga aaattatccg atgagctgga 546721 agccatcgat tgataaagct gaaaagccta tttataaagc acttgcaggg caattggaac 546781 aggatatttt aaacggagtt ttattacctg gaacaaaact tcctccacag cgagaattgg 546841 ccgattatct agatttaaat gtgagtacga tttcaaaagc atttaaagtg tgtgagttaa 546901 aagggctgct gagtgcgact gtagggagcg gcacatttgt atcgtatgat gcgttgtcga 546961 atgcgtattt acttgaggat actaagccga cacatttaat tgaaatggga gcaatacttc 547021 cagatcacgc ttcatatgag cccttgttat accaactgaa aaacatggtt catgaggagg 547081 attatgaaaa atggtttagc tatggccggg caggtgaaag cctttggcaa aaagatgcag 547141 ctgtaaagct catccaaaga ggcggatttg aaacatccgt tgatcacatt ttatttgcaa 547201 atggagggca aaatgcgatt gcagcgacat tggcgagtct ttgtaagcct ggagatcgca 547261 tcggagttga ccatcatacg taccctggat taaaaactgt tgcatcattg cttagtgtgc 547321 aaatcgtacc gataaaatca gaaaacgatg aaatgagtcc ggagtcactt gaatatgcgt 547381 gtaaaaacga aaatattaaa ggtttgtatt taatcccgga ttatcataat ccgacgactt 547441 cctttatgtc tgttgagaat cgaagaatgg ttgcagacat tgtaaagaaa tataatctgt 547501 ttgttattga ggatgcatcg taccatcttc tcaacaaaaa tccgcttccg gcactcgcct 547561 cattcgcacc gcaacaggtt attcatattg caagtttatc aaaatcgtta gcgccaggcc 547621 tgcgtttggc ttatgtagca gtgccgagac aatataagga gccaatatca aaggcgcttt 547681 ataatttaaa tataactgtt tccccgctat tagctgaact tactgctcgc acgattgtat 547741 caaatcaatt tgaagtctta attgagagtc atcgtgaaca aaccattcgc agaaatcaac 547801 tcgtaaaccg atatgttgcg ggatatacat gtttaggtgt tgaaacaggc atttttcgtt 547861 ggttgttgtt accgggtaaa atgtctggtg ccgaatttga agaattggct gctcgacttg 547921 gcgtgcaagt gtatgcggct gaacgctttg tagtgggaaa tagttgtcct gaaagggctg 547981 taagggtttc tgtctgtgca ccaaaaacac ttgaagagct tgaacaagga ttaatgatcc 548041 tgagacgttt gctagacgat cttacctaat attgtttgcc atacaattat gacattgtat 548101 ggcttttttg tgcgtgttat gatgatccac atctagaggg aggtttatac aaaattggct 548161 tttagaaagg aaggtcagat gatgttagac aaggacagcg taaaagcaat agatgttcaa 548221 actgcttcat tacagagcta catcagttca ccagaaaaac aaaaatcgtt atacaagcgt 548281 acactattcg ttgtgagtat ctcacaaatt tttggcggtg cggggctggc ggcaggagtg 548341 actgtcggtg cgcttattgc acagcaaatg cttggcactg atgcgtttgc tggtttgcct 548401 tctgctttat ttactttagg gtcagcagga tctgcattaa ttgttggaag actttctcaa 548461 cgttatggcc gtcgaacagg tctttcagct ggctttatga ttggcggact tggagcaata 548521 ggcgttatta tggcagcaat cataaatagt attttcttgt tatttatttc gttgcttatt 548581 tacggtgcag gtacagccac taatttacag gcccgttatg caggtacaga cttagcaaat 548641 cataagcagc gagcgactgc tgttagtata accatggttt ttactacatt tggcgcagtg 548701 gcaggtccaa gcttagtgaa tgtgatgggg gatttcgctc tttctattgg tgttccatca 548761 cttgctggcc ctttcatttt agccgcagca gcatatatgt tagcaggtgt ggtccttttc 548821 attatgcttc gtccagatcc attagttata gcaagaacaa tagaagcggc aaatgaagag 548881 cctggtgata aaggacattt ggcggcaact gagcatacag aaaacaaaaa agggataatc 548941 gttggggcaa cggttatggt tcttacccaa atagtaatgg tagctattat gacaatgaca 549001 ccggttcata tgagacatca tgggcatgac ttgggtgcag tcggtcttgt tattggtttt 549061 catataggtg ctatgtatct cccttcactt gttacaggtg ttcttgtaga taggttggga 549121 cgtaccgcaa tggctatttc ctctggaaca acgttgcttt tggcaggtgt aatagcagca 549181 tttgctccgg gagaatctat gattcttctc gtcattgctc tttctttact gggattaggg 549241 tggaattttg gtttgataag cgggactgcc cttattgtag attcaactga tactgccaca 549301 cgagctaaaa cgcaggggac agtggatgtt ctgattgcgt tgtcaggagc tgctggcgga 549361 gcattatctg gaatgattgt ggcaggttca agttacctcg cattatcact tattggaggg 549421 attttgtcct tattactcat tccggtggtg gtatggtcta ggggccgcta aagggtagga 549481 ttgtttaatt tacattaatt tgttatattg ttagataaag tatattgcag catctaatat 549541 tctaacgaac tatagttgct ccattaaatc tattataaag atttgaccag gattccttat 549601 agctgtgtca ctcactgcat attctttaat tgaatcacat aaaatggtta tcggatttga 549661 aaaaggcagg attactcgct ttaggtaaag gagtcataac gttgttaaaa aggttttctc 549721 ttgttattgt tacactaatg atgtctatcg ttgttgtttt agcggctgct aaagagtcgc 549781 ctggagatca tgtcatctca tttgatgaac ctattatctt gatgatctca attggaatcg 549841 ttgtattttt attgatccct ccattagtca tgtccttttt tggcaatttg gttgtaagaa 549901 taatatctgg tgtataccaa tgttttatcg ttttcacttt tctggggctc attccaattg 549961 gatttcttat tcccaatggc tttttgacaa ttctagtttc tattgcagga actttagtca 550021 gtatagctag tgttgccgta accttatgca ttggcaagaa taaaaaagat atataatcat 550081 cgaattgtta ttttttcaga ttgtcagtga aataattata caaaaagaga aggcttgtgg 550141 gccttctttt tttgttgttg catcatcccc actttgagct taatctattg aataataaga 550201 gaaggaacct atagaagaat aaaataaata ccgagatgtc aaaaataaaa ctggacttca 550261 ttattgtgaa ttcacgtaaa tgtaaaaaga ttggaaagag gggaattcct tcatgacaaa 550321 tagcagaaca aatccgaagg ttgatgaatt tttaagtaaa gcgaaaaagt ggaaggaaga 550381 atttgagaag ttgagaacca tcattcttga ctgtgagctg actgaagatt ttaagtggat 550441 gcatccttgt tacacatatc ataataaaaa tattgtttta atacatgggt ttaaagaata 550501 ttgcgcgctt ctgttccaca aaggcgtctt attacaggat acagatggaa ttctcattca 550561 acaaacggag aatgtacagg cggcgcgcca gattcggttt acaaatgttc aggaaataaa 550621 tgagctagaa aacattttga aagcctatat tcacgaagcc attgaagttg aaaaagccgg 550681 tttgaaagtg gatgttaaca aaaatattga attgaacatt cctgaagaac ttcaaaataa 550741 attcgatgaa atccctgcat tgaaaattgc ttttgaagct ttgaccccgg gacggcaaag 550801 agcgtacact ctttattttt ctcaagccaa acaatccaaa acccgagaat cgagagtcga 550861 aaaatatgtg caaaaaattc tcgatggaaa gggattaaag gattaggcac gccaaggttc 550921 aggctaaagg aatagcatca tagcgtaata agatcatttc tatagaagaa aaacaagcat 550981 agtaagatgc ttgttttttc ttaggacaac attcacttac tgctgaaatg cttctaacat 551041 tgtatgccac tagacagcgt tataaaatat taatgcaaca cctagaaatc tatccaatga 551101 aatagctcaa tggtatggct cattacattt agaatgccta ggagaactaa tagaaccgga 551161 agatttttag caagttacta cactccaaac tttgtttttg tattaatata ccttattaac 551221 cattgttttt agtcaggtgc agacaaacga atactgatta atgaatcatc atgatatcaa 551281 tgagccgctt gattttttca tcgtcgcctg tatcaacgta cactgttttt ctgtttttta 551341 tgatactctc agtcacttcc cgcatgacgc ctttttctat atcatcagcg gaatcccagc 551401 gtaaaggcac attatataca tgaattgtgc catccccatt gccatgataa gtgactgatc 551461 catccactaa acgagaacct gccaactggg tcacattttc tggatagctg gcacttgtat 551521 catcattagg attaattggc tcgccagccg caatatgtcg aacatttaat tcatctatct 551581 cttgattagg tccaagttga agccaaactc tggcatattc aattttttcc gaagagtatg 551641 ctgccaatac attgtcttct ttgcttttct cttctgctga agaggtatca tttgcagctt 551701 ttgttgcgga ttcttctgat tctgttattg gctccgcttc atccttgcgt attttggtgc 551761 tctcttcagg ctcagtgtgt ttttcgtcag tttgcacagc agaagcttga tttgaaggtt 551821 gttgtgcttc tccatcctta ctgtccgtac atccagcaag caaaatcata agcagcaggg 551881 cagtattgca ataacatatc tttctgcgtt tcttcatttt ttcattcctc tctattaatt 551941 caggtcagct tcatatataa gtttatgtat ctaaatatta ccatggaata gataggatga 552001 tattgaaaac tgtttaagaa gaggaaacga tcttgaatag catcgcgaaa acctaagaat 552061 cttaagaagt tttgcccctt tttcttcagg tattgaatgt aaagtgggat ataaatgcaa 552121 acaaaaacga aatgccttat ccacctcgtg tcatggcaga aaaagtgggg gatttattag 552181 agcggatttg ataatggcgg caggtaaatg ggtgttgact tatatgtcta agcgggagac 552241 tcaagtctgc tcgatcgcat acaaaatacc aagggccagc aacccttggt atttttatac 552301 cttcatgcat ttttgaagtt tatgcttaaa ggtctgcctt actttgcaaa tcgccgagct 552361 gctgcaacgc acatgataac ggcgatattc actgctacga gtgcccagcc cactttctcg 552421 tgcagaatca ctgaggcaag cagcagtcca aaaaaaggct ggagaagctg gagctgccca 552481 accgctgcaa ttcccccttg ggcaagacct cgataccaga acacgaagcc aatcagcatg 552541 ctgaataagg atacatatgc aagactgagc agtgcgggaa cgccgatcgc cgaccatgag 552601 tccggcgtaa aaaagaacga caatggcagc ataagaggaa gcgacagaac gagtgcccat 552661 gagatcacct gccaattccc cagacgccgt gaaagtttgg ccccttctgc ataaccaaga 552721 ccgcatacga caatagaagc cagcatgtac gcgtcgccaa gcggggatga acctcccccc 552781 tgaatgaggg cgaaacctgc tactaacaag ctgccggcag ctgagaaaat ccagaagacg 552841 gggcgagggc gttcaccccc gcgcagtacg ccgaagactg ccgttgcgag tggaagaagt 552901 ccaatgaaga caatggcgtg tgcggatgtg acatgctgaa gcgctaaagc tgtcagcaac 552961 gggaaaccaa tcactacgcc gaacgctacc actaacaatg aaatgagatc tcttttggca 553021 ggatgctgct gccggaagat gagaaggaga cctcccgcca gtacaccagc tatcgcagca 553081 cggcaaactg tgagaaataa cggatcgaag tctgacacag ccaaacgggt cgcaggcagc 553141 gagccgctga aaatgagtac gcctataaaa ccatttatcc agccatttgt tgttttgttc 553201 attataatca ctccacatat ctttcttgtt cattgtctgt attttcttaa caaaaccagc 553261 agctaaggat tacaatgact ataaactgga attggccttt tataaacagc cagttttcat 553321 aaaaaaatgc ataccagtta ggagaacaac gcgcaaatgg atatcacgcc ttttttgaat 553381 agaactctgg atattccgct ttatcagcag ctttatcggt attttaaaga aaatatgcat 553441 cggggccgta ttcaaaaagg aatgaagctt ccttcaaaaa gactcctggc gaatcagctt 553501 tccatcagcc aaacgactgt agaacgtgcc tatgaacagc tcgctgctga aggttatatt 553561 gtgagcaagc caagaagcgg gtggtttgct gattatcatg attctgattt tgcttatgat 553621 agaatgccaa gcacaacacc cattcaacaa gaagcagaag aaaataaaca atggattgat 553681 tttcattatg ggaatgtaga ttcttcttac ttcccttttt ccgcatggcg aaaaagcatg 553741 gtcaatagct tagaccaata tggacacgag ctttatcggc cgggacatgt tttaggagag 553801 tttgagctga gaacactcat tgcagagtac ctgtatcaat ctcggggggt tcattgcggc 553861 cctgaacaag tgattatagg tgccgggaac cctattctgc tgcaaatctt gtgccaagtt 553921 tttgagccga atatttctat agggtatgag gatcctggtt atccaagagc acgcaagatt 553981 tttgaagcca accgcatgaa tattgttcct ataccagtcg atgatgaggg aatctgtata 554041 cagaagatca aagaacagca gccaaacctt gtatatgtca caccttccca tcaatttacg 554101 ctgggaacca taatgacaat aaacagaaga attcagctgc tcaaatgggc ggccgaaaat 554161 caatccttta tcatagagga tgattatgac ggggaattta ggtacacagg acagccggtt 554221 ccttctctgc aagggcttga tcagcataac cgtgtcattt atatgggcac tttttctaag 554281 tctcttttgc cctcgctgcg tatcagctat atgattcttc cttcgcctct tttaaaaaag 554341 ggtcatgaaa tcacgtcctt atataagcag acagtgtcct gccacagtca gctaacccta 554401 gctgaattta taaaaaatgg agagtggcaa aaacacatca acagaatgag aaaactttac 554461 cgcaaaaaaa gagccattgt attagaggca gtgcaaaggg aattaggaga gcatgtcaga 554521 atccgcggag aaaactctgg gcttcgtatc ttacttgacg tttatttgcc atttggtgaa 554581 aaagagttaa ttgagaaggc gaaaaaacat ggagtaaaaa tttatcctgt ttctctttct 554641 tatcaacatc atcctcctac aaaaacggtc tcgctcgggt ttgcaggggt ttctgaatcc 554701 gacataagag aaggcataaa aaaactgaag gctgcctgga agatatgagg gagctttcag 554761 tttagcaaaa cggccaagtg acgactaagt gttgagagct gttcaatatt ttttaagtat 554821 atgatgagtg cctgcagtcc aggccacgat acgtctgttt agcgaaaaac agaatttttt 554881 atttgctcct cacagtgcta aaataaacaa aatagacaat tgaaaaaata gaggtgtaag 554941 aatgaagtta gatgagttta caattggcca ggtcttcaaa acgaaatcat taaaagtatc 555001 aaaagatgat attatgcggt ttgcgggtga atttgaccct cagtatatgc atgtagatga 555061 agaaaaagcg agtaaaggca gatttaatgg aattatcgct tccggcatac aaacactggc 555121 catatctttt aaactttgga ttgaagaagg tttctatgga gacgatatta tagccggaac 555181 agagatgaat catatgacat tcataaaacc cgtatatccg gatgatgaat tgtttacaat 555241 tgttgaggtt cttgataagc agccaaagag aaatgaattg ggaatactca cagtattgct 555301 atctacttat aatcaaaaag aagtaaaagt gtttgaaggt gagttatctg tattgatcaa 555361 acgataactc agaaagcccg cttttcgcgg gctcgattga agcagatggg tgaaagatgt 555421 tagcgggttt cctttgaaaa ataagaggtt aaaacatcat aaacaatagg caaagaagta 555481 aatccctcat cttctagaaa atgacctccg tgctgaactt catataacgc agcatcaatt 555541 tgttgtgcca gatccttgct gaatgaaaaa ggcacaattt ggtcgtcctt agaagcaatg 555601 acagcacggt gcttcgcgga ctcgatgatt ttttgatgat caaacgatcc ctgtgtaaat 555661 tcatctaaca tctgtaaagt gggcaatgat ttggcaaagc cggaaacaag tatgattccg 555721 ccaagctgtt ttcgtaattg aagatgttcc aaaaatctca aaatggcggg gcaacctaag 555781 ctgtgcgcaa ccaaatacgt attttcatgt aaagtgtgct gatataaaga gagtgtatcc 555841 agccaatcct caagtcttgg ctggagcgga ttaggcatgt ttaaaatgtc tgcttggacc 555901 ccatctgcga gcagacgttt tttcagccaa gggaaccaat gatttgttga ggaggctctg 555961 tagccatgaa tgatatagac ttgttttgtc attatttcct cctaagaaat attttcattc 556021 agtataaaat tcctctcatt gggaaacaag tacgcacttt tttgtaagta gctttacata 556081 tgaggccctc cttgtgccat tccccactta cacatctcat ctatgagggg atacaaagat 556141 cgccctctgt cagataacga atactctact ttcagtgggg tgtgagaaac ctcagaccga 556201 tgaataaggc cgtcagtttg caattcctta agctgtgcgc ttaacatttt atgggtgatg 556261 aagggcatag cccttttcag ctcgccgtat ctcatcgttt tttcacaccc taactcatag 556321 agaattctca ttttccattt gccccctata agagataagg tgtattcaaa tggggcttgt 556381 ttactgcggc acaggctatt cattgtaatc aaacctcctt ttttaagtat catatcagaa 556441 taaattagga ttttcggtgt tgaagtttga gggcgattca cgatctgaag tgaaaggggc 556501 cgcttgctca acaggcggca cggtacatga atgttctaag tcaaagaggg ttaccttact 556561 gttagttact ttatttaaaa aaacgcatgt ttttagctga aaatatctat tatggtatat 556621 ttaaatataa agaaatattt gagaaatgag gaatggtatg aatacaccca aaaaacataa 556681 gaaatttaaa gcgaaaatga ttctccaaat catcatggtt atcattggag gaatcatagc 556741 ggcatatgga ctagaaacag tgctcattcc aaacagtgta tctgatggag gggtgacggg 556801 tcttagcatc gttggttcac agctattcaa cttgccgctg gggattttga ttgctgtgat 556861 caacattcca tttgtctggt taggatataa gcaaattggg aaaagctttg cattattatc 556921 aattatcgga atcgtatcgc ttgccgcggg gacaagcttt ttccaccaca cacccgctat 556981 catagaagga gataccctgt taattaccgt tgtcggcggg attatccttg gattcggaat 557041 ggggctggcg ctgcgtaatg gcggcgcatt agatggaatt gacatgcttg ctgtgctgct 557101 atcccgaaaa ctgccattcg gaacgagcga tctcattcta ttcttaaacc tatttgtgtt 557161 tatttttgtt tccacagtat ttggcttaca aggggcattg ctttcagtca ttgcttacta 557221 cattgcatcc aaagtgattc atgttgtgga ggaaggctta agcggctcta aaacctttca 557281 aattattaca acccaacctg aattaatggt agagacaata cgtgatcaat taggccgaag 557341 cgccacatat aaagaagctt acgggggttt ttcccacgag aaatttaaag aaatcacatg 557401 tgtcatcaac cgtttagaag aaaccaaact aaaggaaatt attaatgata ttgataaaac 557461 tgcctttgtt accgtgtatg atgtagctga agtgaagggc agcaatttta gaaatcttaa 557521 tcatcactaa aaaatagaat gaccttttta accgtaactg acatgccgcg ggtaatttaa 557581 tcaaaaacac ttttttgagg cttgtgggtg aataaccggt gaaggtctga atcacagaaa 557641 taccaagggc gtcaaaaccc ttggtatttt ttctggttat tagattttat cttcagcttt 557701 acgtgctgct tcgagcttat caatcctgtc tttatatttt tctccccagt ccttcatgtg 557761 caggataaca ggttctaatg ttcttccaaa ctcagttaaa gagtattcga cttttggagg 557821 gacctgttta taaacctcgc ggtgaatcac gccatcccgt tccaattctc ttaattgtag 557881 cgtgagcata cgctgggtaa tttttgggta tagttttcga aactcattaa acctcttttt 557941 accgtcaatg agatgataaa gaagaatgcc tttccactta cctccgatga tatctaatgt 558001 tgtctccacc ggacatcctt caaagtcatc agaagaataa tcaatgccga gtttacgatt 558061 tctcaagctg ttcactccta atagtatact ttttgatact atatacattc aatgtgcgta 558121 ctttttatat tttaatatac atcatataat gatgtcacat ctaaggaatg aaaggaatgg 558181 atcatatgaa aacactcgta ctcgttgtac atccgaatat agaatcctct cgtatcaata 558241 aaaagtggaa agaagccgtt ttaagtgaac cagatgtaac tgtccatgat ctttatgaaa 558301 aatatcgcga tcaaccaatt gatgtggaat ttgaacaaca gcagctcctg gcccatgacc 558361 gtatcgtttt tcagtttcca ttatactggt acagcagccc accgctttta aaacagtggt 558421 ttgatgaagt gtttacgttt ggctgggctc atggtcccgg cggaaataaa ttgaagggga 558481 aagagtgggt aactgccatg tccatcggtt cacctgaaca ctcttatcaa gccggcggat 558541 ataacttgtt ttcgataagc gagctgacaa aaccgttcca agcatctgcc catttagtag 558601 gcatgaccta tctgccttcc tttgccgaat atcgcgccaa tacaatcagt gaccaagaaa 558661 ttgccgaaag tgcgaatcgg tatgtaaagc atattacaaa tatagaatta aacccgaagg 558721 ttcgcctgca aaggtatttg aaacagctgg agagtgtcga tttaacataa agattgattt 558781 ttgaaaatcc tgtactcacc aagcaggatt ttttcttgtt cagcagaggg attttaacat 558841 atagcaaaaa aagaagaagc caccaaaaat aagctatttg cttggtcctg actgcttatt 558901 tttggtgaaa tacttatttc tctgtgatga aataaagcaa agcgatgacc ggaaaagcga 558961 ttccaatcca taatgctgta ctccatccgc ctgaggcata tgcccatcct ccaattgatg 559021 accctatcgc accgcctaga aagaagatcg ccatgaataa tccgtttaat cgactgcgaa 559081 tttcaggcgc caacgaaaaa atagcacgtt gactgagcac aaggtttgca gatacaccca 559141 tatctaacag aatagcagcg gccactagaa ctgttatacc gacgggggag ctgctctgaa 559201 tcatgagcgg cagtaataaa gagacaacga caacaccgag agcgattcca gtggcaagcc 559261 tggttaagcc tcgatcagcc aggcggccgc ctattggtgc agtgactgca cccgcaatgc 559321 ccaccaatgc gtagagtgct attgccttct gagaaaaatg aaaatcagga ccggacaata 559381 ataaaggaac agttgtccag aacaagctga aagctccaaa tacaaacgca tgatagatgg 559441 cacggcggcg taagactgga gtcgtgcgca gcagcttcca cattgaaccg agtaaggcag 559501 tatagtttgt atttgctgtt ggttttctgg caggaagcac ttttgataat acgatggcca 559561 ggataacact taccacggcg gacaaagcga atattgcatt ccacccccag atatcagcga 559621 ctagactaga tatcggacgg gaaagcataa taccgagtaa taagccgctc atgacattgc 559681 caacaacccg gccgcgtgca gcgtctgatg caaggtatga tgcaaatgga acaagcactt 559741 gggctgcgat tgatcccaat ccgacgaaaa acgcagctgc taaaaacagt gttccatgct 559801 tcacaaatgc tgttagtgtc aaagccgctg cgcttagaag gagcgataca acaataagtt 559861 ttttgttttc gataatatct cctaaaggga caaggaatag taagccggca acgtatccga 559921 tttgggtgag tgtgacaatc aatccagcac cgcttggaga aagtccaatt gccttactaa 559981 ttaatccgac caagggttgt gcatagtaaa gattagcaac aatgataccg catgcagttg 560041 cgagaagaag ggttaaactg ggtgaaatcc tctgacctgc ttgtttgttt ccattagcca 560101 tatgaatgaa ctccttttta agtggttttt tgagtgtaat catgacttct cacaagtgat 560161 tttataaact gaacgttcag tttcgtcgat taataaaaat aatatactaa acgttcagtt 560221 ttgtaaatgg atttctgttt tcttttttta ttcaatttaa gtatactgaa cgtatagttt 560281 atattgcggg aaggaatgat ttatgtgcag agtaaacgag ggcggccgcg tgatgaagga 560341 acgcataagg cgattctctc tgcagcctat gacctattgc tggaaaaagg cttcgatgcg 560401 gtgacagtcg ataaaattgc cgagcgtgcg aaagtgagta aagcaacgat ttataaatgg 560461 tggtctaaca aggctgccgt tatcatggac agctttcttt cgaccgcgac ggacaggctg 560521 cctgtgcctg atacagggtc gtcagtacaa gatatagtaa cccacgccac gaatttagct 560581 aggtttttga caagccggga aggaaccgtt attaaggaat taataggtgc agggcagttg 560641 gatgaaaaat tggcagaaga atatcgcacg cgatttttcc agcctcgccg cctccaagcg 560701 aaaggccttc tagaaaaggg aattcagaaa ggtgaattga gagagaatct tgatattgaa 560761 gtaagcatag atctcattta cggaccaatt ttctatcgtc tgcttataac aggggatgag 560821 gtgaatgatt cctatgtgcg tgatttggtg atgaatgcgt ttaagggagt tcaagctacc 560881 tctgctacag agagtatgta gctgataaga actgcaaaag ctgcggatta tatgacaaat 560941 tggttccatc gtacagtgaa atataagatt tttgttgctg agcggaatca tcgagggaaa 561001 agttctctta tcggatgtcg aaaaagaagt cattcaatcg tgaatacata acatcatatt 561061 attacattcc ttttcatcga ttggaacaag ggttctatac ttcaatggaa taccgcaaag 561121 ttggagtatt taaacaacag gggaaaatcg atggccatta tgtaggtgtc atggcaatgg 561181 aaaaaatact tgcaatgtaa acaggcctct aaagagacct gttttttaat atccagatga 561241 ttgtctagtt tcagcttggg ctctatgacc actcccataa ctgaaatagt ctaatattta 561301 taccagaagg gattgtttat ataaataaaa gtttatataa tgacgggggc gctaaggaaa 561361 cgcggggagc gactcaggtt ttcgtttcaa agttttgatc cttaagatat acggagcgct 561421 acatatggaa acgtaaaggg gaatgtataa tcatttggcg tgtatataac gatttgctta 561481 tatattgatt tgggaaggag gagctcatat gacgattgat gttgcggcga tgactcgttg 561541 tttgaaaaca cttagtgatc aaactaggct tatcatgatg agattatttc ttgaacaaga 561601 atattgtgtc tgtcaattgg ttgatatgtt cgaaatgagc cagcccgcca taagccagca 561661 tttgcggaaa ttaaaaaacg caggttttgt gaatgaggac agaagaggcc aatggcgtta 561721 ttattcaata aatggttcct gtcctgagtt tgatacattg caattgatct tacatcaaat 561781 tgatcaagag gatgaattgt taaaccatat caaacaaaag aaaactcaag cgtgttgcca 561841 gtaaggaggc attagattga catcaatgat tttggcagta ttcatctttt tattaactct 561901 agtattggtc atatggcagc cgaaaaattt atctataggg tggtcagcct gtggaggcgc 561961 agttttagct ctaatagcag gtgttgtcaa ttttcatgat gtgttaactg tgacagggat 562021 tgtttggaat gcgaccttgg cttttgtggc catcatactg atatcgttaa ttcttgataa 562081 tatcggtttc tttgaatggg cagcgcttca tatggctaag gctgcaaaag gatacggtgt 562141 gcggatgttc gtttatgtat ctctattagg agctatcgtc gccgcgttat ttgcaaatga 562201 cggtgcagct cttatattga caccaatcgt attagcgatg gtcagagcat tacattttaa 562261 tgaaaaatta gtttttcctt ttatcattgc cagcggattt attgcggata ccacttcgct 562321 tccttttgta gtaagcaatt tggtcaacat tgtttcagcg gactattttc atattacgtt 562381 tattgattat gcatccagaa tggttgtccc gtacctgttt tcgctgctgg cgagcatcat 562441 tgtactttac cttttcttta gaaaaagcat accaaaacgc tatgatctga ctgaggttaa 562501 aaaacctgtt gaagcaatta aagatcaaaa catgttcaga ctgtcatggt atatcttagg 562561 gctgctgtta attggatatt ttgcaagtga atttttttct atccctgtat cagtggtagc 562621 gggcagcatt gcaatcattt tcttaatcgc tgcgcaaaag agtccggccg tccatacaaa 562681 gaaagtggtg aaagaggcgc catgggctat cgtattcttt tcaattggca tgtacgttgt 562741 tgtgtatggt gtccgaaatg ccggattaac ggatgtcctt tcagatgtga ttcaagccgc 562801 agctgatcaa ggattgtttg ctgggacaat tggaatgggc tttattgcgg cgattctttc 562861 ttccattatg aataacttgc cgactgttat gattgacgca ttggccattg ccggtacaga 562921 tacacatggg atgatgagag aagcgcttat ttatgcaaat gtgatcggtt cagatttagg 562981 gcctaaaata acaccgattg gttccttagc gacattatta tggcttcatg ttctttcgca 563041 caaaggtatg aagatttcct ggggcacgta ttttaaaaca ggaattatcc tcacgatacc 563101 cactttattg atcacacttg tcggcctgta tatttggctg ctgataatcc attcttgttt 563161 ctaaaaggac aaggtcacta tatcaaggaa aacaatgcac tggtaactct tgccgcagcc 563221 aaatggctga agggtggggg agaaaatacc ttggggctaa gtggaatgtg tacagcgcag 563281 gaatcgaagc tcaaggatga catcgagtgc tgtcaaagca atgaaagaag cagggattga 563341 tatttcaaat caaacatcgg agaaatttga tgatccggca aaagcacacg gaacagaaga 563401 agtgtttcca aagggtccgt gatgaaattg gtgaccgttt aaaacagttt gctgtaactg 563461 gggaataaag aatcgatata ttcagcgttt tcttgggtta tataatacaa tgtgttgttc 563521 aacaggtgtc tgcgagctga gtgcagacac ctgtttttgt ttttatttgt ctgagattcg 563581 taacagggaa gttatttagc tggtgacaga ggaaaattga tttgtgaaca gaatcatgaa 563641 ggagacggtg ttttaaagga gttgtctgtt ttgcaggaat taacaaaaaa aaaatacagt 563701 agcttaaaaa caatgtttga tgacaaatat tgtcccacat ttgtctattc aatattagac 563761 caaaccattc cgggagctgt ttatgcagat gatcaaacct ttcctaaatc gttttttata 563821 ggaactgaat caggcattta ttttattgcg ggagaccaag ggaatcggga ttttcatgat 563881 ttcattgcag gatattatga agaacaagtg aaatcatcaa aacgatttac cttgttttct 563941 tccagtgata catgggatag cgtactgaaa cccatactga aagatgactt aaaccaaatg 564001 agaagagctg cattttctta tcaaccaaaa tctttcaaaa agactttgca actgccaaag 564061 gggcttgtat tgaaaagaat tgacgaagac atcatttcac atagcacagc gtttaacagc 564121 gcgtattatg aggagtattg gaattctgtc tcacagtttg cttcaaaagg ttttggattt 564181 gccgtattac atggcaatca cgtagtaagt gagtgtacct ctatattttt agggcataat 564241 cgagcggaaa tggatatcta tacacttgaa gaatatagag gactggggtt agcttattgc 564301 gtagcaaata ggtttatagc gttttgtatg gaaaatggga ttgttcctag ctgggattgt 564361 gatatttgca acaattcgtc cattgcatta gcagctaaac tagggtttaa gacggtaacg 564421 gaatacacta tttactactc tggctaacct taatgaaaga accttaaaag gagataccaa 564481 ccgatgttgg tatctttttt gttttagagt ttttttaccc ttttagcaga aaaatgggtg 564541 atgaaaatct tattcatttt atttactttt aggtaggtaa aacatacccc gccaactgta 564601 accactccgc ctagcagaga gagcagtgtg ggtatctcgc cgatccagag ccaagatatg 564661 atcaaggcta aagccggtgt aacataaagt gaaagggttg cttctgaagc accgacgaat 564721 gaagtgacat atgctagtgc gaagtaagga ataaccgtcg gcaataatcc taagtaaacg 564781 atagacaaag ttgcgcttat tgaagcgttc atcatctctt cgcctaagcc tggcagaaac 564841 acaagcatag gtattgttcc gccccaaatg gtgaatgtaa cgaatggaat aaaaccatat 564901 ttttttatat agcgggcttg aaaaacgaaa taaatactct ccgaaaatgc tgccagcagg 564961 atgaccaaga taccgctcat tgaatatgta aagtctcccg ccccaaatgc aatcaataat 565021 acacccaata aactgatcat agagccaagc catttcgtaa atccaaaatg ctctttataa 565081 aacaggcggg atagcatggc tgagaagatc ggtgccgtag taacgagtaa gcttgcaact 565141 ccggcactaa ctgttttttc accgatgttc agcaaaatgt gatagaatgc aaatcctaaa 565201 aaccctaaaa gaaaaatggc aggaatgtct ttcaagtcgg gtaggcgcat ctgagtcaaa 565261 acagcaaaaa gcaataatgc catagagccg attaacaaac gaaataaagc aaggtgttct 565321 ggcgtgtacc cttcaagtcc tgcgcgaatt cccggaaaag cagatgccca taaaccaatc 565381 atgagactat gagatatcat tatttgaact gttttctttc gcattcctct cactcctctt 565441 tacaaaaacc aaccagttat ttaatgtgtt tctatactaa taaagatttg atgatatggc 565501 ttcaaccagt tcaatagatt ttgacccaac caatttattt taaggagacc gattctatga 565561 gctttccaga agaaaaaaag atgaaaaagc tccctaagta cagacaaatc gttcatttta 565621 ttaaagagaa aataggaaat ggagagtggc cgattggaag caagattcca agccagcgca 565681 cgcttgcaaa agattttcag gtaaatcgga gcacagtgat tacagcgtta gaggaattga 565741 tggccgatgg gctaatagaa ggcacaatgg ggaaaggcac agttgttatc aacaacacat 565801 ggacactgat ggctaagaat tctgctcccg attgggatca atatgtcacc tctggcattc 565861 agatgccaag ccgaaaaatc gttcaagaga taaatcaatc agaatcaaat acagacctta 565921 tacagctcag taaaggtgaa ctttcagctg agatttttcc tttggctgtt atgaaagaga 565981 tgatggggaa ggtatctcaa cacatggagg cattcggata tgaagaacca aaaggttact 566041 tacctttgag ggaggcatta agcaactatt taaaaaccat tggaatcaac gtctcatctt 566101 cttccattct gattgtctca ggagcgttgc aagccttgca gctgatatca atggggctgt 566161 tacaaagagg atcaaccgtt tatcttgatc agccctccta cctttattca ttacacgtat 566221 ttcaatcagc tggtatgaag ctgactggac ttcctatgga taatgaagga cttttgcctg 566281 aaaatgttca tttaacaaga ggagagcggg gaagggctat cttatataca aatccatgtt 566341 ttcacaatcc gactggtatt cttatgtcta aaaagcgacg ggaagaaatc ctagcagtaa 566401 gtgagaatac acagcttcct attattgaag atgacattta tcgtgagtta tggatcgatg 566461 aaattccgcc atatcctatt aaaacaattg ataaaaatgg acacgtactg tacataggaa 566521 gtttatcgaa aacattaagc ccaggtttga ggattggatg gatcgtcgga ccggaaccgg 566581 tgattgaacg tttatctgac attaaaatgc aaacagatta cggatccagt tcgctatccc 566641 agagagtagc ggcagagtgg tttacttccg gccactacca gcagcatgta gaaaaggtta 566701 ggcagcaatt aaaggtgaga agagaattgg ccttgagtgc tttagaaact catttgaaag 566761 aagtggcgac atggaatatc ccaaaaggag ggttttttgt ctggataaaa atattgcctt 566821 ccatatcaat gaaattactt tatactaaag ccttatcaaa agggattctg atcaatctcg 566881 gcagtatcta tgctcaggaa aaagggaatt atattcgctt atcatatgct tatgcatctc 566941 ttgaagacct tcaaaagggg atttatgagt tgggtttaat gattaaagaa ttggcaagca 567001 ggtaactttt atatccttaa atggatgttt cactaaaaaa gagatcaagc ctaatgatcg 567061 cttgatctga taataacaag ggttactaga atagaccaaa tcatggttcg gtcttaaaat 567121 aatcatgtct ctgaacgaaa agtctttccg acttctcttc ctaaaccaaa gtagtgtctg 567181 aaattataga taagcgggct ccatttggaa gggttgatat ggttttcgtc cagaatgata 567241 ctttcctcgg catgaaaatg tagtgcctgc gtctctacaa ttgcgaatga cgattcatat 567301 tctggaagcc gaatgtgttt cacttcggct tcgatttgga tagggcattc tttaattcgt 567361 gttggtgata ctgtttttga ttgtaaaggc gttaaccctg ctgcctcgta tttttctttt 567421 ttatatgtaa atccgatctg cttctttaaa ggcggtatac tcttttttcc gctataagat 567481 gaaattcttt caacgttttc ccataaatcc gggccaggca agtttatgac acactctttg 567541 tgtctttcca aattgtcgat ggcttttcct cccagtccta ctccaaggat tatataatgt 567601 ccaagagccc aagaagaaga cataggacta atattagtgg ttccatcctc attcaatgtg 567661 gttagaagaa atgtcgaggt accataatac atgatcttgg gtttgatttc cttaaatcga 567721 cgagtgtctt gttttttgat gtccaacgtt ttttcctcct tgtcacgctt acatttatat 567781 tgtaaaggat taacatttca actatcatcg aaatatgaat gtaaggagga aaatcatgaa 567841 tcctaatatt gcaaaaatct cttcgttgct atcagatccc tcgcgttctt ccattcttct 567901 cagtctgatg gatggaagga tacaccctgc gggagagctt gcatatctcg ctaacattaa 567961 acctcaaact gcaagttttc acctgaataa attgcttgaa gcaaagctga ttagcgtaga 568021 gaagcatggg agacatcggt attacagatt ggctgactca gatgctgcaa atgtgatcga 568081 acaattgctt catattgcgc ctaaagcaaa agtcaaatct ttaaaagagt caaaagagaa 568141 aaaggacttg catttcgccc ggacctgtta tgatcatttg gcaggttatg tgggcgtgca 568201 aatggcacat tcactagttg agcaggggat gttaaaaaaa gttgatttaa actttgaggt 568261 gacttcagag ggtgctttat tcttttcgaa gttaggcatc aatgaagagc aacaacggaa 568321 taagaggaga gcctttgccc gctgctgttt ggattggagt gaacggcagc atcatattgc 568381 aggagcatta ggaaacgccc tattggtgcg catgttagaa gaagaatgga tcgttcgtat 568441 gcctaaaacg agagcgatta ggattacaca aagcgggaaa atcgcgtttg aaaagcacct 568501 aaacgtgaag atttaggatt ttgaagcgga aacatcagat gatgaggcac gatatctagg 568561 aggagtaaga tttgttctaa tcttactcct tcttcttatt ttgaagcagc tcgattcccc 568621 attgcaatag agatgcggtt ccaactgttt atttgattaa tgatcagaac aaggtcaaca 568681 tattgttcct catcataatg ttcccgcacc cgatgatata gctcatcagg aaccctttta 568741 gatggaatga gcgtgatgtg ttcagatagt tcgagagccg ctttctcttc aggtgagtaa 568801 aaatcacatt cattccaagc atgtaaacag taaattcgct gttcagtttc tcccattttg 568861 cgggcatcgg acgtatgcat atctatgcag aaggcacagc cgttcatttg agagactctg 568921 attttgatta gttctctcgt cgttcggtta attgaggatt gtttcgtgta tttctccata 568981 tccatcatga ttttcatacc ttcaggtgca atctcatagt aggacactct ttgactcata 569041 aagcaagact cctttccata gaatacctag attgtatccc ggtattgatc attttaccaa 569101 tgtgcggttt gaatgacagc tgtttcagcg tcttttggaa agaagcttct ttgaataaaa 569161 ataagggtag ccagcaatga tgagtggagc tgctaatgca agcagtatcc atgagcctga 569221 ttggctgtct ctagtgactc taatgaatat ataagtaccg atcagaaaat ataataaagc 569281 acctagaaac caatacatgt tcattcctct ttttccttgc tttttggttg cgcatttttg 569341 tctgtcatat ggcttaatcg atcagggttc tgatttttta ataccttttc ggtccggatt 569401 ccttttctct ttaatgataa aattgtgaga tcaatcgatt tcaatgatga tcattccttc 569461 aatgaatagt aagttcctta tgattttaaa ggtaaatttg aaaagataaa acgtacatag 569521 aggcagaacg ttcatgtacg tttgggcaat gatcacttgt tggaaactct aatgtttccc 569581 tgcacctgat attgttgtgt tccttctctt cctataaaat gattggatac atgtatgttt 569641 gcacgttgaa atatgggttc gattttcatg aatctctatt cggtgaaaca ggtaaaggaa 569701 gtggataagg tttgcttata aggaatcctt ttaaagataa atattactca catgataggc 569761 gggcattaaa catgcttgca ctcagagtgc cgggcctggc ttttattctc atgatctata 569821 tagcctctat cgtgctgcaa tttgtttctg ggggctggtc cattttattg ctttatgcgt 569881 ttaccatatt aatcgccatt tttgctttgc ttcattggca ctcatatcgc tgggttaaga 569941 aaagagtgat tctgtatttc gcggtacaag gtttgatcac ctttgcactt gctaatctca 570001 tgactggctt ctttatactt gtgattatcg gcctttatgc atttttaatt ggacaaatta 570061 taggaatggc agacagaaga aggacttttc tcattcttta tctattgctg ctgctggtca 570121 taaattcggc gtatcacctt cataaaggtg aagttttgca ttttattgtt attgctgcgc 570181 cgatcatgat tgtcatcatc acttatgccg caacattttt tgcccaagtc gatgaaaaaa 570241 taaaagctca attgactctt gaaaggctgg agctggctca tcagcaggta gaacagctga 570301 cgctgcagaa cgaaagacag cggatggccc gagacttaca cgatacgctt gctcaaggtc 570361 ttgtcagttt aaatatgcag ctggatgcga ttcatgttca tctcgccaaa ggcaacacag 570421 agagagcgaa ggaaatcata caacaatcga tgaaaagagt gaaaagcaca atagctgatg 570481 cacgttcagc tattgacgat ctccgcagca aatcagaaga aatcggtgtt ttaaaagaaa 570541 gaattacctc gctaatggat cattttatag agtcgacagg catggcttgt ttattagatt 570601 acagattgca tcaggtgctg gatgtgcgta cagctgaaaa ctgttattac atcattggag 570661 aatgcatgac gaatgcggca aagcatgctg aggcgaaaac aatctggata tccatttggg 570721 atgatgaaaa gggaaggctc catttaacag ttaaggataa cggcaaggga tttgatgttg 570781 aaaaaggaaa gaaaaagaga ggacattatg ggcttcttgg catacaagaa cgcgtcaggg 570841 caataaatgg ccaattcaat atcaagagta caaaattgaa aggaacacaa attgagatca 570901 ctgtaccaat tcagggagag atgcaagatg aataaggttt taatcgttga tgaccatctt 570961 gtcgtgaggg aaggtctgaa gcttttaatt gaaacgaatg atcaatacac cattatagga 571021 gaggcggaaa atggaaaagt agcagtccgt cttgcagatg aattagaacc ggatatcatt 571081 ctgatggatt tgtatatgcc ggagatgagc gggttagagg ccattaaaca aataaaagaa 571141 aaacacgata cccccatcat tattttgact acatataatg aagatcactt aatgatcgaa 571201 gggattgaat taggagcgaa aggatatctg ttaaaagata cgagttcaga aacccttttt 571261 cacacaatgg atgcagccat cagaggaaat gtgctattgc agcctgatat ccttaaacgt 571321 ctgcaagaaa tccaatttga gcggatgaaa aagcagcgca atgagacgca gctgacagaa 571381 aaggaagtca ttgttctaaa agcaattgct aaaggtctta aaagcaaagc gattgccttt 571441 gatttgggcg tctctgagcg aacagtaaag tccagattaa cgtccattta caataaatta 571501 ggcgcgaatt caagaactga ggcagtaacg attgccatgc aaaaaggtat tctgacaata 571561 gacaactaaa ctgcatattt gaaaattgcc caaacgtaca tgcccgaatg tacgtttttt 571621 tcatttcatt gtcaactaca atgagaaaga atgtgatcaa gcaatgtgtt gaaaggagat 571681 tatcatgtca aaaatgttat atacattagg aggatgggtt gctcgcaatc gcataaaagc 571741 aatatgtgcg tggatcgttg tgttagttgc tgcgataggc cttgcagtga ccttgaaacc 571801 aagtttttct gaggatatgt ccatacctga cacaccttcg gaaaaagcga tggatgtgat 571861 tcaaaaagaa tttcctcatg gtcctgataa agggagcata cgggttattt tcggtgctgg 571921 tgatggggag aaacttactg ggaagccagc aaaaaaagca atagaagata cgttcaaaga 571981 aatcagtaaa gatgattctg ttgactcgat tgcaagtcct tttgtgacag ggacaatcgc 572041 gaaagatggc acagttgcct atgctgatat ccagtataaa tcatcagcag atgatataaa 572101 ggattactct atcaaacact taaaagacag tttgaaaatg gctgatgatg aaggattgca 572161 aactgagcta agcggagatg taccgggagc ggagatggag ataggcggtg tctctgaaat 572221 tgtcggcatt atcttggctt ttgtcgtttt agccattaca ttcggttctt tattaatagc 572281 aggtttgccg attttaactg cactgattgg tttaggtgta agtattggac tggttttgat 572341 tgggacacaa gtatttgata ttgcttctgt cagtctttca ttagccggaa tgattggcct 572401 tgctgttggt attgattatg ctttatttat ttttacgaaa caccgccagt ttttaggcga 572461 aggcatacaa aagaatgaat caattgcgag agccgtggga acagcgggaa gtgcagtggt 572521 ttttgccgga cttactgtta tcgttgcact ttgcggatta actgtcgtta acattccttt 572581 tatgtctgcg atggggctga cagcagggct tagtgtactg atggctgttt tggcttccat 572641 cacacttgtg cctgcggtct tatcgattgc agggaagcgg atgattccga aatcaaacaa 572701 gaaaatagaa aaacaaagca ctgaaacaaa tgtctgggga cgctttgtca ccaaaaatcc 572761 tatcatgcta agtgtatgca gcattctgat tttgatcgtc attagtatcc catctatgca 572821 tttggaactg ggcttgcctg atgctgggat gaaagctaag gataatccgg atcgccgggc 572881 atatgacttg cttgccgaag gctttggaga aggatttaat ggccaattaa caatcgtagc 572941 ggatgccaca aatgctacag aaaataaggc ggaggctttc gcagatgcag tgaaagaaat 573001 aaagggctta gaccatgtag caagtgtcac tcctgcaatg cctaataaag aagggaactt 573061 tgccatcatt acggtcgttc ctgaaacagg tccaaatgat gtcacaacga aagatttggt 573121 acatgatgta cgcagtttat cagataaaaa cggagtagat ttgcttgtta ctggatcaac 573181 tgcagtgaat attgacattt cagatcgcct gaatgatgcg ataccggtgt ttgctgtact 573241 tattgttggc tttgcgtttg tattgctgac catcgttttc cgttcgctgc ttgtgccgct 573301 tgttgctgtt gcaggtttca tgttgacgat gacagccact cttggaatct gtgtatttgt 573361 cttgcaagac gggaatctca tcgacttttt caaaatacct gaaaaagggc cgatactcgc 573421 gttcctgccg attttatcga ttgggattct gttcgggtta gccatggatt atcaagtatt 573481 ccttgtcagc agaatgcgtg aagaatatgt aaaaacaaac aatccagtac aagccattca 573541 ggctggatta aaacacagtg gtcctgttgt tacagcagcc ggcttgatca tgatcttcgt 573601 ttttgcagga tttatctttg caggcgaagc ttctattaaa gccaatgggc tggctctttc 573661 ctttggtgta ctctttgatg cctttattgt aagaatgaca ctgattccaa gtgtcatgaa 573721 gctgatgggg aatgcagcct ggtatttgcc gaaatggtta gacaagatta ttccgaatgt 573781 ggatatagaa gggcatcaac tgacaaagga aatacagccg gaaatagatc atgaacaaaa 573841 gaaacaaatc agtgtgtaat agaaaaagca gatcttttat gatctgctct tttgcttatg 573901 gtagtattta gaagatgaag tcggcagtta aaaggagacg cttatggcgc catcactcat 573961 tttcgatatg gatggaactt tgtttcatat tggcagaagc tgcatcatac tagcaggcat 574021 cccaggagaa gtgacatgat tttttgactt tgcattcact acttgatgcc aaggatcttg 574081 agaatccttc ttgaaaataa aggattttac aactgatcat ataagaaacc taaagaaaca 574141 agcacacaaa accagctgcg ggttttgtcc aagaaaaata gagtccataa gagggactct 574201 attttttgaa gtgcccggct agaagcatat tgcaggactt tatgaatgca aatcactatc 574261 ttataagccc ttaccgtgaa atgcctgttt ctgcattgaa aaaacgcatt acacgttcat 574321 ttacgtaagt gggttgttcc atcgataaaa catgtccggc atttttaatg acttccgcct 574381 caatatctgg aacgaatgaa gaggctcggt gcagggctga gtggggatca tagatgactt 574441 catgttcacc aagtaataat aggataggaa ctcttgctga acgtaattcc tcatcggtaa 574501 aaacatacgg aaatccgtcg gcattaggat ttggatttct tgatccatcc tgccacatta 574561 cccctgcctt aaactgcttc acaaaaatcg ggtgcagcac attctgatca ttcatcatcc 574621 aatttaagaa tgtttcaact ccatttgacg ctgtaaggcc aagagcgtat ttgtagaaat 574681 cgtgatgaaa tggcaaaaac gtttctgccg gactcagtat agctgcgctt tttactctct 574741 caggcatacg taaaaggaaa ttcatcgtat ggagaccgcc aagcgaaagt ccgatcatgt 574801 gggacttttc gatccccaga ttgtcaaaca catcaagaag ccaattggcg taatccgttc 574861 ttgtaccgct tacattctca ggaatactct tgtttttatc acctatgata tcaactgcat 574921 aagttctgta tttactgctc caatcggcga tgttgggata ccacatcgtc gagctgaata 574981 atgctccgtg gagtaataca agcggcgggg catcctctgg gccgcttgca atcacatgtg 575041 tttgaccaaa acgagtagat atatagaatg atttacaacg gaccggccaa agactaaggc 575101 tttcattata agtttgataa tagcggatac cgttgtcact taattcggga atactagatg 575161 aatggtttga catacaaatg cccctcccaa ttttgtttaa atgaatgtgc cgtttcgtga 575221 tggggaatct gattttgata taacagactt tatttacaat ataatacagt tgttattaga 575281 cgtcaaatcc aagatgaaaa ggaaaaaaac gattgaaaca gattattgaa aatcaatata 575341 acagaatatt aacctccttt gtggagccgc ttcattaaaa ccgcaatcca aatgcatgaa 575401 tcacaaaaat cacaacagga gggatcagga gggaaggcag cagattcagt gttttgaact 575461 tcttgattcc aagaatgctt agacctgaac tgaggatgag tatgcctccc acaattgtga 575521 tttcattaat aaggtctgta ttgattgcgc tctccattac ttgtgcaaat aaatagatgg 575581 agccctgcca ggaaaataat acaagtgcgg cagccgctat tccaaaacca aaagttgaag 575641 cgagcacaat ggaggtgatc ccatctaaca tcccgtttgt cagaaggtat gtataatctc 575701 catgcaaagc ggcttcaaca gggcctaata ttgacagcga acctatacaa aataataaga 575761 ccgcagttga taagccctct gctaaattgc ttttagaaaa tttgttcacc agcttgttga 575821 atcgtaattc taaattgatg atctggccta gcaaacctcc aatggctaaa ctcacgatga 575881 atagaatggg gtatttacta tcaggcaaat gctgtgtaat ggcgttgatc cccagtgcga 575941 ccgcagcgaa tcccattgcc tgcatcaaaa tatcctggta ttcatcttta atgccttttt 576001 tgaatatccc cccgattatg cttcctgcaa tgatcatcac tgtgttaaaa atcgttccaa 576061 acataagctt tctcctccaa aaatcattcc tgcataaaaa ataaaccctc tagttagtag 576121 agagtcaagg gagatcaaaa catattcatg agattatttg atgggcagca ggatttcagt 576181 cacgtaatta tctaggttat tcgtaatgcc ataatcaatg agtgtgattt cgattgagtc 576241 ccctgctacc tcataatgat gttctttcat atatgccagt aattttttgt agtatggttc 576301 ggcttctgga tgtgaccctt taaacctaat ttgcagatat tctcttgaag gaaagatgat 576361 ttctgaagaa gttttttcat tttcatcttc aagaatcata aatatactgg aatatttgtc 576421 aaactgtttt gctttcacat ttgctgcaga aatggataaa ccaatcttgc ctatgaatat 576481 atcttcgttt acattcaggt gggttctcaa ttcagctaac gaatgttcga tatcatggcc 576541 gagaacatat tcatgctgca aataggccac acgcattgcg ggaagtttga tttttgaaat 576601 ttgatgtaac ggcatgttaa cggcatcttc tatatgtgtg atgcgtcggg agatctttcg 576661 ttcaatgcgt tccaattctt tcttcttgcg atcaatttca acctgctggc tttttagtaa 576721 atgaagaaga gtgtttgtat tttgagagtt ataaaaatca agaagcttat tgattggcag 576781 gcctagggcc ctcaaatact tgatggtatc cagccgctca aactgttggg tagaataata 576841 tctatagttc gtttgctcat ctttatattc cggtttcaaa aggccgattt catcataata 576901 ccgaagagca gagattttca cattgaataa ctttgacact tctccaatcg aaaaaaattc 576961 cttcattcta acaacctttc tgtcctatga ttgatataca cacattatat agtacggcga 577021 gtactaaagg taaagtttgc agcataaaga aaaaactcct tctaaaaagg agcttttcat 577081 tcttcgaaat aaggatttac atggatgagc acttcttcta catctgaaaa ctgtcttttg 577141 atttcatttc gaatttcgcg ggcaatgtcg tgtccctgct taattgtcaa atcatgatcc 577201 aaagataaac ggacatcaag caatttatag tggccatgtt ctcgcgcgcg gattctatca 577261 attcgtttta cctgatcaca ttgaaaaata acagctttat attcctctat cagctcggga 577321 tcaacactct tttccatgag cacatcaaca gacggcctga ttaattccat tgaaatctta 577381 aaaatgaggt aagcaacgat tgcactggca atggcatcgg cgtacaacag ataggaccat 577441 ccacggctgt ttccgatgat agccaacagg acgccgataa aagcggcaag agaggcaacg 577501 atatcgcctt tatgatcgta cgcaatcgct ataatcgctt tgctgttcca ttttttccct 577561 tgctttatag aataacgata taagatttcc ttagccacgt acgaaatcag agccgcaaac 577621 aatgcgctgt attggggaac gcttggccct ttaacaaagg acagaatcgc ttctatgagg 577681 atataaacgg atacgatcac taagataatt cctacaatcg cctcactaat gacttcagct 577741 tttccgtgac caaaaggatg gtcttgatcg ggcggtttat tggaaattcc gatcactgcc 577801 aagactgcaa tcgaagcaac gacatctgcc gcggaatgta ttccgtctgc aaacacggct 577861 tcactatcgc ctaccagccc aaaaaagacc tttcctgcca ttaagatcag attggcgatc 577921 aatgcaatca aagcaacttt tctgcttatt tgttctcttt cacttgccat tttttcctcc 577981 tataaaactg cacaaaaaaa taggagtgct ctatatacgc tctccgtatc ctttcctgtg 578041 taatcacttt gtttatcata ccaattcaat ttcgagtggg tctatagcaa cgttgtttcc 578101 tgtttactaa taaataaggt gacagaaaaa aagttggagc tatgctaaaa aggtcataca 578161 gcaaacaaat gagttcttat gtaacaacag tgatgattcg ctattaaaat gctgccgtca 578221 gtgaaaaatt tccacctaat tttcaaaaac ctattgacat gagaagatct gtattttact 578281 attatctcat attcaagata ttttaatttg agatatttgg tcggaaagat cagcgatcaa 578341 gcgcaactct aagtgttcaa tcgttgtcag ttcttttaca caatattcaa tatgattttt 578401 tataacataa tatctcgaat tcgagataaa agggagtgta gcgtaatggc tgaatttact 578461 catttagtca atgaaagacg atctgcaagc aattttcttt caggtcatcc aatcacaaaa 578521 gaagatctca atgagatgtt tgaattggtt gcattggcac catcggcttt taatttgcag 578581 catacaaaat atgtgacggt tcttgaccag gacgtaaagg aaaagctgaa gcaggccgca 578641 aacggacaat ataaagtggt tagctcttct gcggttctct tggtattagg ggataagcag 578701 gcatatcaac aagcggccga tatctatgaa ggtttaaagg tattggggat attaaataag 578761 caagagtatg accacatggt gcaagacacc gtttcgtttt atgaaaacag gggagaacaa 578821 tttaagagag atgaggcgat aaggaatgct tcactttctg cgatgatgtt tatgctgagt 578881 gctaaggaaa aaggctggga tacctgcccg atgatcggct ttgatgcgga agccgtaaaa 578941 cggattttga acatagacga ccaatttgag gttgtcatga tgattacgat tggaaaagaa 579001 aaaacagaga gcagaagacc gcgcggctac cggaagcctg tgaatgagtt tgttgagtat 579061 atgtaaaagg agcggataaa aatggctaaa aaaacgatgg gaattcatca tattacagcg 579121 attgtcggtc accctcaaga gaacacagat ttttacgcag gagtgcttgg gcttcgtttg 579181 gtcaagcaaa ctgtcaattt tgatgaccca ggtacgtatc atctttattt tgggaatgaa 579241 ggcgggaagc cgggaacaat cattaccttc tttccgtggg ccggagcccg ccaaggcgtc 579301 attggagacg gtcaagttgg cgtgacttcg tatgtcgtgc cgaaaggggc tatggcattt 579361 tgggaaaaga gactagaaaa gttcaacgtt ccctacacca aaatcgagcg ctttggggaa 579421 caatatgtag aatttgatga tcctcatgga ctgcacttag aaatcgtgga aagagaagaa 579481 ggagaggcta atacgtggac tttcggagaa gtaacgcccg atgttgccat taaaggtttt 579541 gggggtgcaa ccctattatc agagcagcct gacaaaaccg ctgacctttt agaaaacatc 579601 atggggctgg agcgagtcgg caaagaagga gacttcgttc gttatcgttc cgccggtgat 579661 atcggaaatg tgattgacct taagttaacg cctattggcc gcgggcaaat gggggccgga 579721 acggtgcatc acatcgcttg gcgggctaac gatgatgaag atcagttaga ttggcaaaga 579781 tatattgctt cccacggata tggtgtaact cctgttcggg atagaaacta ctttaatgcc 579841 atttacttca gggaacacgg ggaaatcctg tttgaaatcg caactgatcc cccaggcttt 579901 gcacatgatg aaacacagga aacaatgggc gaaaaactga tgctgcctgt gcaatatgaa 579961 ccgcatcgca cacaaattga acaagggctg ctgccgtttg aagtaagaga gttagattga 580021 tttgacacat aaaaaataaa gaaacatata ttcaattgat gattgctgga tggtactgtc 580081 agcaaagaat cagataaaat caaagatgag gagagataca aatggaagat gcaggactgt 580141 tgcttattcg tataatgatt ggtgtggtgt ttttgtttta tggcacacaa aaattattcg 580201 gctggtttgg cggatacggg attaaaggaa ccggacaatg gttcgaatca attggggtga 580261 aaccaggaaa cgttgcggcc gctctatcag gtcttgggga gttagtaagc ggaattctat 580321 ttattttagg cgtattcctc ccgcttggag ctgctatcat aacaatcatc atgttaggtg 580381 ctatcgtaaa agtccatgga gcgaaaggtt ttgcgaatgg cgccggaggt tttgaatata 580441 acctggtgct cattgcagtt tccatagggg ttgcactcat cggttcagga gcttacgctt 580501 tgcattttta atacgaaagt atgtaagaac agttgctgct tgtcagtaac tgttctttta 580561 ttttcacatt ttcggcaagc ttgcaggtac tctgcaaagc aaaaaagcgg atatcataaa 580621 tataaatctg tatagtgaat gatacgtatt gatgagcttg gtcatgaaaa acagacctat 580681 ttgaaggagt aaatggatga aagagatgac aggattacat tcattagttt ctatagaaaa 580741 ctttatcaaa cagcacaaat tcagttttat ttatatatca aggcctggct gtacagtatg 580801 tcacgcagtt ctgccccagc tcagaatagt attggatcag tttccaaaca tcaaattggg 580861 gcatatcaat gctgacgatg tagcagaggt cgccggcaga ttttcagttt tcaccgttcc 580921 tgtgcttctt ttgttcattg atgggactga gtttctaaga gaagcccgtt ttgttcattt 580981 tgaacagctt gaacaaaagc tgaaaagggt ttatcgatta tatgaaggcg aataaaggaa 581041 taaggcaaaa aaagaactca aatgagttct ttttttattc ttcactaggc gaagaagggt 581101 tatcaacctg cccttgatca cttgtatcat tatcacaact tgctgaaata ataattgaat 581161 gagaaggaga gtaatctcct aatgtgaaat tcactccgta atttttgctg ttcgcagtat 581221 ggctgttttg caagttttgt ccgatatctg tattggcgtt ttgtgtcatt ccatttatcg 581281 tgagatttga gatgttgatt tgagatcgca tgcttcaaaa actcctttca ctcagaagta 581341 gctgtcataa aggacgctgg cagtctattt acttctatga tattgcgttt ttatatcatt 581401 gcatcaacat aatggtaaaa ataatagcga gtgaatgatc atcttttgaa gatgatcaac 581461 ctatcagcag aaataaagcc gcctgataaa gaggcggcag atcgttatat gtcatctatg 581521 aatttgatgt atcgtttttc gtttgcctga aggataagat agtcgttttt aatgatgagt 581581 aggagcctat agcagcgtag ccataaaacc agcccataaa tacgccagaa aagaggctgt 581641 gtcgatggct tatgaaaaca gaaatgacaa ggcctgttat taaggcaact gacggtacaa 581701 aagttttggg gattttcaat aatattttga ggatttgggt tatcaatatg atgattggaa 581761 cagctatcac agcatcccaa aagttcgtgt gaataattgg aaaagccata cggcacctca 581821 tgaagtgttt atttcttaat ttttacgcta aaagcttgga aagcagctct tggatcgcat 581881 atgttacatt ttgggcttga ttggcggagc ttgtttggct taaagcattg gattcaaaaa 581941 ccaaacctgt attactccca ccggaaccct ctgttgtttt agacacagag aacgggctga 582001 tggaaactgc aaatccgtta ttaaaaacgc tgttcccgga tatcgaatga atataaactg 582061 ggaatttcat cattcatctc tcctctctgt tatgactgtt tatacaatat ggtgtgtgag 582121 cagcagttgc ttaaacaaaa cggcaaaaac tttcagtaag agacaaaaac ctgcaaaatg 582181 ccacaagcgc cttttgttaa tgcagctttt tagggacgtt ttttttattt tttttgccaa 582241 cttcatcaaa aatattctga ttgccagact gggcttgtcc gtccttattt atgaaatcgg 582301 ggtgaatgag ttttttcaga tccctgactg ttaaaggctt ggcgtcatca gttaattcta 582361 ttcctaattg cccgtttgcc tctaatgtcg caattttgac atcttgtata gccgtaacgc 582421 cgtgaagcct tagctgcatt tcaagctggt cagctgtaag tctcatcttc tttaagtttt 582481 cgatatgaag ctgtccgttt tcaatgacga tttttgcttt tccggttaac atcttttcaa 582541 tggtgttcga tttcatttgg atccattcca taacgatgag tgtgcttgtg aaaattgccg 582601 ctgcaattaa tgttttgaag aggctgtact cgatgattgg ctgaacgata atagttccga 582661 tcgaaatcat gacaaccgtt tgagtcgacg tcatttgtgc gattgatttc cttcctgaaa 582721 ttctcagcaa aatgaccccg gctacaatga gaacaagaga ttcccaagtg aaattcatgc 582781 taccacctga ccaatgatga attagatttg tcatgggatt ggcttttctt ccggccaatc 582841 gcaatttaat atatccgaaa ggcagtcggt tcattctgtc ctgaaccgaa caatattttt 582901 ggtatagatg gatatattaa gccaaacaat gatagcaaca ggagtttttt ggccgaaaca 582961 atctgggaag cggggagcgc cataacatga ttgaacttga agttgtcatt agaacggttg 583021 ccagctttgg cttgctgtta atcgcagaac gaattttagg caaacagaca atctctcaaa 583081 tgacgatttt tgattttatt gcggcgatca cactaggggc gattgctgcc ggattagctt 583141 acaatacttc aataaaaccg cacaatatgg ccatttcgtt tagtattttt gtgctaacca 583201 tttttctaat ttcgtttctg tcgataaaga acaggaagct gaggaaattt tttgccggag 583261 atccaacagt gctgattcaa aacgggaaga tacttgaatc aaatatgagg aaaatgcgtt 583321 acacacttga ttatttaaat cagcaattac gggaaaaaga aatatttaat atcgaagaag 583381 ttctttttgc cattcttgaa acgaatggtc agctgactgt gttaagaaaa ccgcaattcc 583441 ggcatgtgac caaacaggat ttaatgattg cggtaaacca agaacaaagg cttccgatag 583501 aacttattat ggacggagaa atcattgaga ataatttaaa gcagaatcgt ttgacggaat 583561 cctggctttt ggaagaattg cgaaaaagag acataaaggt gaaagagacc gtgtacgcag 583621 tgctgctggg taatggggat atttatgtgg atcaatataa agaccatata tcagtcccta 583681 tggataagga atgaaggaac aatcaatctt aaagcccctt attgaacgca acggtttcaa 583741 cttgtcttgg gtacgaaata tgcagaagcc cgtttaacag ctgaatctgt aacaaatgag 583801 tttcagcggc ttcgggaagc tgaatgattc gctcaatttc tccgtaatac cgttcacgca 583861 gcacttccat ttcggctgga aaaacaggcg tgatcgttcc tttgatcagc agctgggttt 583921 tagacagtaa acggatcgtt aattcttcct catacacacc gggcatttcc acaatgataa 583981 aattatattc ctcatcttga taaaagtcgt aaacaaacgt agaagcttcg gaatcaaaaa 584041 aatgttccgg ggctttatat ttgagcacat ttgtccaaaa gtcactttgt ttatattcat 584101 tcgtaatctc aagccacttt cgaatttttt cgaaatccat atgagattct ccttaaattt 584161 gatttgaaat cggcgcagaa gggtttccga tttggtcttg gtcactaacg tctgaatcaa 584221 tatttccagt gtttaaaagt gaagacgtag gcgaaagatc ccctaaggaa aagtttgctc 584281 caaaatattt gctgttcgca gtatggctgt tgtgcacagt cggaccgaca tctatatttc 584341 cgttttgcgt gacgccgttg atcttaatat ttgcgatatt aatttgatat ggcatagacg 584401 aaaccccttt aatctaaaat tggcggtggt gcaatcggag gagcattaac gttggatgta 584461 tcagagttgc cgatagatgt ctggtcattt acatcaggat cgtttaagaa gttttccatt 584521 acggattctg taggtgatgt atcaccgaaa gaagagttgg tcccttgaga tttttgattg 584581 ttggtagggc tgttataagc agcttcgcct attgtaattg aaccattgcc cgaaatactg 584641 ttgatcttca aataatatag gttgattact gtagacggca tcccatcaca cccttccatc 584701 tttctgtaca gtacattatg cgccgctgca cccaattgtt ccttgcattt acgggcaaaa 584761 ctctatctgg ccccggagtg atgctcaatt atcagtgaat gaaaagccat tgatatagga 584821 atcaatgaat tgattcagtt attcgaaatg catgagacct tttaataaag gaagctggca 584881 aacaggatca gtttgaaata attgacaatg aagctaatgc catgaaataa tactcgtgag 584941 taacattact cgtgggtatt atttttgggg tggtcctagt tgaaaagtaa aggagtagaa 585001 agccgaaaac gattacttaa agctgccgct aatgaatttt cggttcgggg attccatgac 585061 gcgaaggtaa gtgaaattgt gaaaaaagct gggttcacgc agccttcatt ttacctgtac 585121 tttcaaagca aagaagccat ctttgccgag ttaataaccg attttcactc tcgagtcaga 585181 aagctgacag agtcacttct tctggaaaac ggattaaaca cggaggatgt gtcaaaacgg 585241 gtactgctag ctgtagagac tgtttttcaa tttttggatg aggacaagga tttaaccaag 585301 atcggctttt ttctcaaccc ggaagcaaaa caaatgaaaa aagacttggc gatggttttg 585361 aaagagaact tagaagcaga acagcggctt ggctattttc actctgaact ggatatggaa 585421 actgtcgctg agtgtttggt cggcatgatt gaacatttaa ccgaatcatt tttgttaacc 585481 ggaatcaaag atccggcaag cctcgcagca gaggttgtga atcttttaat ttacgggatg 585541 cttccgaaag ggaatgatgt aagatgatat ctattatgat gaaagtcagt ttggcagttt 585601 ttatgcttgc gggaggcatc ataaaggtaa gccgcgttcc ctttcaagtt gagcattggc 585661 ggcattatca atatccatta tggtttctga ctgttactgg cattcttgaa atagccgggg 585721 cacttgctat gacagcggga atttggaatc ggtatgcagc aattggagca ggtgttctgt 585781 ttgtcgttct catggcggga gcaattcatg cgcatatgtt tcgagcaaga caatctgtca 585841 tcatggcgat acaagcgatg atttgtttga ttgtttcaat catgatcatc atggggagtt 585901 acacgtaagc ttttcactaa tgtttaagaa caagcccatt tgcaggaaat ctccttttct 585961 tatcgaataa tagaaagtcc aggaattaac tgaatcagta aaatagagct ccatttctgt 586021 gttattcgtc cggcatcagc tgggcttttt ttataaagga ggaatacagg atggcattca 586081 ctttggaaga catgactgag gaagagttcg aagcctttcg cgggatgtcc gtgcaaaatt 586141 ttgcgaaaca aaacataacg tcaggaactt ggacggaaaa agaggcattt gagaaatcgg 586201 agcaggcata tgagaacatg attccgaatg ggcgagacag cagcaatcat tatttttgga 586261 acatcacaaa tgaccaagga gaaagaatgg gctggctctg gctgtatgct gatccattac 586321 atccgcaaaa ggaagcgttt atctattcct ttggattgta tgaagccttt cgcggaaaag 586381 gacttgctca attggcgctt caaacgcttg atgaaagagc aagagagctt ggtgcggaaa 586441 ggctggctct acatgtattt gcacacaacg agacagccgt ctatctttat cagaagatgg 586501 gctatgccat gaccaatata cgtatgcgga aacagctatg ctgaaaagcc gcttacgtta 586561 cccaaataca acatgcctat ctggaagcgg tggcagggta ctataagtca tcattagaaa 586621 gattaaggtc atgggaggct tgaacatata aagaaaaagg acaacagctg ttgtcctttt 586681 caatgccgct tgaactttct ccctcagtct tttttgtctt gatgatccag ctcttttatt 586741 cgtttcgtaa gctcattgaa agcctgatca agctccttat accctttatc atttggcgtc 586801 ataaaactga gctttcccag cacttcttgt ctttctgtct caagctttaa ccgaagctcc 586861 tcccgctcat ttctttctga aggaacgtcg tttaactgct tttcgatgcc gttgtttgag 586921 atgacgagtt tactgtttgt tgttttttcg agaaagtatc ggtcatgtga aaccgccagc 586981 aatgtgccgc tgtattgtga cagtgtttct tccagctgtt cgcgtgacgg caggtcgaga 587041 tggtttgtcg gctcatctaa aatcagcacg tctttttcct ccagaatata tgccatcagc 587101 ttgatcttta cacgctcacc catactcata tgcttgatcg gttcagtcca ttgggcggct 587161 gtaaaaccta agtgcctcat cagattttga acgtgccccc ttgctttgaa tgtttcattc 587221 tcaaataact cttccggtgt ttgttctaaa ggcaaatcaa acacctcctg cgttaaatag 587281 ccgatgtttg cggacggcga cacccataca cttccttctg ctgtttcctg tcccagaatg 587341 atgttcagta atgtcgtttt tccgctgcca ttggggccta tgatcgcaac cttttcgccg 587401 tgctgaattg taaagtttgc gtttttaaag agagtccttt ctccaaacgc ttttgttaca 587461 ttctgaactt ctaaaaaacg ttttcctgtt ttgtgggttg tatcgattga aaagcggact 587521 gtatattctg gggtaacggg ttccgccttt gctttttcaa gctctttttc aagccgcttc 587581 tgcttggatt ttatctgggc atccgtacgc ttcgctttta cccggtgata ttctttaaac 587641 ccttcctttt tcgtcgattg agcatgggct ttttccgacc aagaagcgag cccattcatt 587701 tgtgcttcaa tccgttcaac cattttttgc tgcttttcat attcacgctg ctgggtgagt 587761 cttttcttct cccggaactt catatacccg gagtaattcc ctttgaattc aatcagcgtc 587821 tgatcctcaa gcgaccatat ttttgttgcg gcttcgtcta aaaaatatcg atcgtgagaa 587881 acgagaatca cagtgccgtt ataatgtttc agctgttgga tgagaaattg caagcttttt 587941 tcatcaaggt ggtttgtcgg ttcatctaac agcagcagat ctgcatcctc tgatagtcct 588001 ttcgccagcc gcgctttcag tttttcaccg ccgcttaact gatgaaaatc acgaagaggc 588061 acatgccatt tctccagtaa cttcttttcg gcaggtgtct gatccgcaaa ggaatacgcc 588121 gcggtttcct gttcaaccaa agccagtttt atatccttcc gaaggatttg accctgtgca 588181 ggggctaagt cattgtgaat gaggtgcagc aacgtagatt tcccagcgcc gtttttgccg 588241 ataatcccaa tgatatctcc ttgctgaaca ctggcgttta catgtttaaa aacagtttga 588301 tcctttactt catagctaac gtttgttaat gttacgatct ctttcatcca tatccctcgc 588361 tttaaaggga gaataaaaaa atcctcccaa atgtgttgga aggattagcc gtgcctgtgc 588421 atgatcaaat aagctatttt ttataaatag cagtgtcgta tatatagaaa atgggcagac 588481 taatcctatt ttttgatttg aaatattgat ttcaaacggt aaaaataaga ttagttaatc 588541 attgtccacc catcatccct tcttgttttg attacaaaca ctatagcata cctttaaatt 588601 caaaagcaaa ggtcattttc atcaaaaaaa ctcctgctct catttttgag gcaggagttt 588661 tgagtcttat tgatgcttcg cttttctcac tttataaatc acaatcagca aaataaacca 588721 aaccggtgtg acaaataagg aaacacgagt atcctgtgcc agtgccagca caaccagaac 588781 aaacgccagg aacgcaagaa tcaggtaatt tgtaaacgga taaagcggaa gcttaaactt 588841 gtttgttttc gctaattcag gtcttgtttt gcggtatttc atatggcaga tgaccgtaat 588901 cccccaaatg tagataaagc atacggttga aatacttgtg atcagggtga atacgccttc 588961 tggcatgatg tagtttaacg taacaccgat taaaatcacg atagctgaaa agaataaagc 589021 atttctaggc actttacgct gagtcagttt cgccattgac tcaggcgcat tgtgatcttt 589081 cgccagggaa tagaccatac ggcttgtact gaatacagcg ctgttgcatg ctgaagcagc 589141 ggatgtcaac acaacaaagt tgataatact tgcagccccg acgatgccaa cagcgacaaa 589201 tacttgtacg aatgggcttt cgctgggatt gatgatatcc caaggataga tgctcataat 589261 cacgagaaga gccccgatat aaaaaagcag cacacggaca ggaatattgt tgatcgcctt 589321 agggattact ttttcagggt tttctgtttc accggccgta agcccgacaa gctcaatgcc 589381 gacaaaagca aacacaacca tctggaacga gaggataaac ccgtgcatgc cattcgggaa 589441 caggcctccg tggctccaga ggtttgtgaa gctggacact cctgagcttg tggaaaagcc 589501 tttgaaaatc atcacaaggc caatgacgat taacgccaaa atggcaatga ctttaatcaa 589561 agcgaaccaa aattctaatt ctccaaaaag cttgactgtc gccagattca taatcagtaa 589621 aataataaga gcgattaagc caggcaccca ttgcggcaca cccgggagcc aatattgagt 589681 gtagagcccg actgctgtca gatcagccat cgcaatggaa atccagcaga accaatatgt 589741 ccagccggtg ataaaagctg ccatatcgcc taggtagtct tgtacaaaat ccacaaaaga 589801 gtgatagttc aagtttgata acagcagttc acccagcgat ctcataatta aaaagcaaat 589861 gatccctgtg atcatataag caaataaaat cgaaggtccg gcaaaatgaa tcgatttgcc 589921 cgagccgaga aataagcctg tcccaatggc tccgccgatg gcgatgagct ggatatgcct 589981 gtttttcaag cctctctgca acgtttgctg atttatattg tctttcgtca tgtcgtctgt 590041 cactttatgt gttcctccat tgaaaattgt ttattgagtc agcaatctat ttttaatgat 590101 tattataaca ctaaaatttc tatctttttt actaaaaaag gattgatgaa aagaatttta 590161 atgtgatttg gactatttcc cgaaaaagcg gctccattta gggagccgct tttttatgct 590221 ttttcagttt ttgtcataaa caggtagagc ccgtaatctg tcggtgcgga tgcgtagcct 590281 gcctgccgca gcattgctgt gatattgccg cggtggtatg tcccgtgatt gacaacgtgg 590341 ggaagcagtt cggaaacagt tgttttcatg attccgcttg agggattttg aatctggagt 590401 ggcttattga gctgttcttt ttgctgtaaa aatagtatat agcgctcgga taacctcaga 590461 aaaaggtctt ccatttcctc tatttcttta gcctctgtct gttctttaag ctgttcagct 590521 aaagccaacg catcgctcaa ggttttgccg gaaaacactt caatccagcc gagatcagaa 590581 agataaacat gagacaatac atgggatatt gacggaaaca cgctttgaat ttcttgatgg 590641 tatatctctt ttggaagctc ttttaatcgg ttgaatattt gttgattggc ccagacgtta 590701 tattcataca atttgaatgc aaaatctgac atgttaaaat tccccctttc gtgtgtatag 590761 ctttcattat acacgaacat gagttcttat gtagagtgct cgaaaataaa atttgttgac 590821 atatatagtt tagaggaata aactaattga cattgaacat aaagtttagc ggggtaaact 590881 ataatgagga ggggaagata ttgaatgaac aaaagctatg tcaggcgata aacctgtttg 590941 tggaagtcct gcttgaaggg acagaatttg tgcatcgtga aatcaatcag gatgtcttca 591001 agcatatctc aagggaacag gcagacctgt tgaaaatttt aaaagtcaag ggcccaacct 591061 ctcccggcag cctggccatg taccaaaatg tacataagag cgcgatctct aacagactga 591121 aaaagctgct cgaaaaggga ttggttcaat gggacgactg tccggaaaaa agtgataggc 591181 gctctaagct tattaacatt acacccagtg gtgaacacat actagaagaa ttagattctg 591241 ccatctttaa cgcgctcaaa ccgttgattg atgatataga tgaggaacac ttacattcta 591301 tcatcgagat attcaccatt ttaaaaagca aatttaaagg aggagattct gccgaatgag 591361 agcaatcatc aaattcaagt gggcaattgc agccatagta ttagcactta ccgtcgtttt 591421 gagtttgttt tctccgaact taacggagct ggccaatcaa aaggggcagg cccagcttcc 591481 cgctgatgct gtttcagaaa gggcaaacgc cattttaaaa caagcgggag aagacaataa 591541 ttcgatcagt gtagtcttta cattagacaa cgctataaag aaagaaacag agaatcagct 591601 ccggataata attgataaaa tcaaaaagat cgacggtgta gaagaggtaa catctcctct 591661 gtcagcggaa aaagaagtca aagaccagtt gatgtcgaaa gacaagaaaa ccgttctcat 591721 gcctgtcacg attacaggtt ctgataaaaa ggcggaaaaa attgcggacg agatttatca 591781 aatcgttcct gatgacttga cggcatatat tacgggagct tcccttatca accaggattt 591841 cgctcacagc tcagaggaag ggcttaagaa aacggaagtg ataacagtct gcctgatcat 591901 cggtttactg ttgatcgtgt tccgatctgt tgtgacgcct tttatcccga ttgtggttgt 591961 cggtttttct tatctgatca gtcaatctat actgggcatc cttgtataca atgttgattt 592021 tcctatctcg acgtttacgc aaaccttctt agttgcgatc ctgttcggca ttggaacaga 592081 ttactgcata ctgcttctta cacggttccg tgaagaattg gcaaacgggc atgataaaaa 592141 agaagcggcg cttatcgctt accgcacagg gggaaaaacc ttatttatca gcggatttgc 592201 ggtattgatc ggattttccg ccttaggatt tgcgaagttt gcgattttcc aatccgcagt 592261 aggggtagca gtcggtgtgg gaattttaat gatcatcctc tacacactgc tgccattatt 592321 tatggtgacg ctgggtgaaa aattattctg gccttctaag aaagtgctgt cacacagtga 592381 taacaaacta tgggcgtttc tcggcagaca ctccgttgcg cgtccgtttc tgttcattgt 592441 catcacggtg gtgattacgc ttccgttcat cttgacctat gatgaccaga tttcattcga 592501 ctcaactgcg gaaatcagca gcgattataa atctataaaa gctctcgagg ccattaagga 592561 tggattcggg gaaggaaaag cgttcccgat caatgttgtc gtaaaaggag acaaagatct 592621 tacaacagct gatacaatcc cctatctagg aaatatcagc aaagcgatcg agaaagttga 592681 tcatgttgac tctgttatga ccattacgca gccgactggt aaaaaaatca aagatttata 592741 tattgataac cagctaggat cggtttcaga cgggctggat aagacggtga aagggattgc 592801 cgatgtccaa agcggattaa cggatataga aaacggactg aatcaaatgg cagggcaaac 592861 cggctcggcc tcaaatggag ggtctggcgg ttcactgggc gatgcggcag atggcttggg 592921 caaaatcaat cagcagctgc agctcgtgag caaacagatt tcccaaaccg gcaataccgc 592981 acagaccgtg cagcagctta cggcaataag cggacagctt ggccagattc aaaccggcct 593041 tgaacaagcg aaccaacagc tctcaggcca gcaggcacaa gccggaacgc tgacagaaag 593101 cctgaaaaag ctgtccgaag gcgtgaaaag cgcaaatgag ggcctgacga aagtctctga 593161 cggtattaca gcttccagtg atatattaga ggacatgagc aaaagtccaa ctgtaagaga 593221 tactggcata ttcattcctg atcaagtaat gaaggacaaa gactttaaga agtcaattga 593281 ccagtattcc tttgcagacg gcaaaggtgt tcaattaagt gtcgttctgg attcaaatcc 593341 gtactcagaa caagctatta cgacaataaa ccaaatcaaa aaagctgtcg caaacgaagt 593401 tgacggcact cctttggaga atgcacagat cgtgtacggc ggggtcacga gtatgaatgc 593461 ggacttaaag gagctatcca caacggactt ctccagaaca atggtgatta tgattatagg 593521 cctgtttatc gtgttaacca ttttgttccg ctcaatgatc atgccgattt atatgatcgc 593581 gtcattgctg ctgacgtact atacgtcgat atccataaca gaattaattt ttgtaaacgg 593641 cttaggaaac gcgggtgtca gctgggcagt gccattcttc agctttgtca tcttgatcgc 593701 gttaggggta gattattcga tcttcttgct ggatcgattt aaggaagagg tgcaccttgg 593761 cattgagcaa ggtgtcgtca ggtcaatgag caaaatggga tctgtcatta ttacagctgc 593821 cattatattg gccggtacgt tcgcggcgat gatgccttca ggtgtcaata cactgatgca 593881 ggtggcaagt gttatcatca tcgggctctt gctttacggc cttgtcatac ttccgctctt 593941 catcccggca atcattgcga cctttggaga aggaaactgg tggccgttcg gcaggaagaa 594001 aggaaaagag taatcgagag aagagtgatg aatggtcatc actctttttt catgactaaa 594061 cgactaactt cagacgtgtt acccaaaaag atcagacgat caaacggcgg ctgtacttaa 594121 aaacaaagag cccggaaaac attcccgggc tctttgtttt atttccattc tgcaattgta 594181 tcaatcggca gacggtagga agcatagcct tcgtctgctg cttttccgat agaaagtagc 594241 ataaccggta cataacgttc tttatctaat ccgaaggttt ccgcgatgtt ttctttatcg 594301 tatccgccga tcgggtttgt atcgtagcca tgcgcgcgtg cagtcagcat cagctgcatg 594361 gaaacaagac ctccgtcaat caggatcgtt tcacggttga cctgtgccgg aagcttttca 594421 aaatgtgcgg tcagcgcggc gatttgtctg tctttgacct cctgcggcat gtaaccaagt 594481 tccacggctt ttgaatagat ttcttctaga tagtctgcgt tgttcatgtc tgcaaataca 594541 gcgatgacag cagatgatgt tgtgacttgt gtttggttaa agcttgcaag cggtgcgagc 594601 ttttcttttc cttccgggct gtcaatgaca agaaaacgcc atggctgcgc gttaacagaa 594661 gatggggcag ttgttgcttc ctctaagatc tctgtcattt cttctttgct gatttttact 594721 gccggatcat agttgcggat agaacggcgg cctttcataa tttccataaa atcgtttgtt 594781 ttgatcatgt tgatacactc ctcttaagct tcgatattat ttatattgtt tcgcatgcgc 594841 gccagcacat caatgagcag gcggcgttct tctgcgctta catttgcgag catttccttc 594901 atgaaacgct ccttttcctt cttagaagac tcaattcgct ctcttccttg gtctgttaac 594961 cgaacaaggg tgatgcggtt gtcctcaggc ttgcgccgcc ttgataccat gcctttggat 595021 tccagctgtt tcaggtgtct ggtaacggct gcgctatcga tatttacttt cttttgaagg 595081 tcgctttgac tgatctcatc tgcatgataa agcaatgtca gcaattccaa acgagattgg 595141 ctgatgcccg tgcatgcctc gaacttcacg ccaatcacct tgttcacgcc ttgcagctga 595201 tataaaatct cggcttcctc tgaacaaaat gacgccaaaa cccatccctt ctttcctgtc 595261 aaaactatta attgatatat caatgattga cacgtcaatt aatatacaac gattgatttc 595321 atcttgcaag ccatttgcac ttttgaacaa cctcccagcg cataaaattc gctaggctag 595381 aacttagcaa aaaaagctgg ccgcttcttc agatgatgct ggtcacgatg attccctgca 595441 tcattcccat ttataggtgt tcggaatatc actttgccgg cccgtgctca agcggctttc 595501 acaggctgaa agttatgata caatatacaa atgtttcaca gcttcaatcc atagttggag 595561 ctgacatcca ttatataagg gactaggttg aagggaaggt ttgataacat gctgcacaat 595621 ccaactggaa aagaacgctt ggcactagcg tttctgctcg gcatgcttgc tatattgggc 595681 ccgcttaata tagatatgta tttgccaagt tttcctgaaa tcgcgaaaga tttatcagca 595741 agtgcttcac ttgttcagtt aagtttaaca gcctgtctgg tcgggcttac gatcggccag 595801 ctgattgtcg ggccggtcag cgatgcgcag ggaagacgaa aaccgctatt aatctgtatt 595861 tttttatttg cgttatcttc tctgttttgt gcactgtcgc ccaatataac aactttagtg 595921 gctgcgcgtt ttttacaagg cttcactgct tctgcagggc ttgtgctgtc tcgcgcaatc 595981 gtccgcgatg tgtttaccgg aagagagctt tctaaatttt tctcgctgtt aatggtcatt 596041 accgcggtgg cgccaatggt tgcgcctatg acaggcggtg ccattttgct tttgccgttc 596101 gcaacgtggc atacaatttt tcacgtctta atgatcatcg gatttttact agttcttctg 596161 attgcattga ggttaaaaga aacgcttccg ctggaaaaac ggattccaag ctcaatcgga 596221 acatccgtca aaacgatggg cagcctgctg aaggatcgat cctttatggg gtacgcgtta 596281 actgtcggat ttattcacgg gggaagcttt gcatatgtgt ctggtacgcc ttttgtatac 596341 caggatatct acggggtgtc tccgcaggta tttagtattc tttttggcat taacgggctg 596401 gcgattatat cgggcagctt tatcatcgga cgctttggcg gaatcattca tgaaaaaagc 596461 ctgcttcgta tagcggtcat tacggctatg attgcgacgg ctgtgctatt aaccatgacc 596521 atgattcacg gtcctcttgc tacattagtc atatccattt tcatttacat gattacgatc 596581 ggcatggttc tgaccagcac gtttacccta gccatggaaa agcaggggca ccgcgccgga 596641 agtgcaagtg cgctgcttgg aatgcttccg ctgctcctcg gttcaatcgt gtcaccgctt 596701 gtaggcatta atgagacaac agccgttccg atgggagcca tcatgtttgt gacagctgtc 596761 atcggctcac tggcgttttt tggattaacg aaagaacgag tagggcagaa ttcataaaaa 596821 aacctgacat gacgtcaggt tttttgtttt atttagaata acaacagcag gcctgcaatc 596881 gccggagtca aaaagatggc tgatttcaaa accacctttg gcatgaggtt ggtgaatttc 596941 gcgcctacat aggccccgca cattgtcccg accagaactt tgacaagtaa aacgtaatca 597001 acaaaacctt ctgtaatata tccgatgcct ccacctacag ccagagggat gatcacaagc 597061 atcgtcgttc cgacagaatg gcgaatggac agattcagca taatcattaa accgatttga 597121 ataaaaggtg ccgacccgat gccgaatgtg ccggaaagaa cgccggctgc aattcctaag 597181 atgaccgctc tcgtatacgt tgaaagagtg ctttgattca cttgagcctt ctcttttaaa 597241 ataaataatc tgattaaaat gagaattgct gataaaaata acattccagc cgtcaaataa 597301 tgaagcaaat cagccggaat aaaagaagtc agcttggcgc cgaaaaatga gccaaccgca 597361 gcaaagcctc cgactattaa gccgattttc atttgaatgt taccctcgcg atagtggctg 597421 tatgcccctg ataagcttgt aaaagccatg ccggcaagcg aagtgcctaa agccgtatga 597481 atcgggatat ggaaaagaag cgttaaaagg gcaatgacaa agccggctcc accggcgcca 597541 ataaagccta aaataattcc tagaagaaac ataacaagaa taatgagcat attttttcct 597601 ccattgaaaa gatgtaaaaa tgtaatcgtg cgctattctg gcggaggtat ggtgtcctat 597661 tgacgaagaa aaacacgccg ttttttcagt tgccagtagt ccgtcgaccg tcgttcagca 597721 aacatatcgt acctcaaatt cagggatctg acaaggcagt ttgttgcttc ccattaccat 597781 ctgttatatg attttgatga agaaaagccc ttgaatatat tcaaaagagg tattatatat 597841 ggacgatttt aaattagata agccgactcc ctactacctg caattttata accagctaaa 597901 aaaaatgatc ttcaacggga cttttaagcc tggggaacgg ataaacgaaa cacagctggc 597961 gaaaagcttt ggcgtcagcc gctctccgat aagggaagcc atgcgattgc ttgagaaaga 598021 tggtttgtta aaagcggatg accgaaatgg gttttcgatc acgtcgttaa cggcaaaaga 598081 tgtagatgag atttataaaa tcagaattcc gctggagcag ctggcagtcg aattagtcat 598141 agacgaagcg gacgaagaag agctgaccat actcgaaaaa cagcttgaag aaacagagaa 598201 agcgattcac aacggcacgg aagatacaga aatcattcgt ttaaaccaaa aatttcatga 598261 gctgctggtt gatttcagcc ataacagaca tttgaaaaat ttgcttgagc atgtaaatga 598321 cctgattcat ttttgcagaa tccttaatta taccggcgac caccgcgcag aaacgatact 598381 gcgtgagcac cgcaggatat ttgaagaagt gaaaaagaaa aacaaagaag cagccaaaca 598441 acatgtgctg gctcatttca atcatgactg tgagcatttg aagcatgtgc ttgaagaagg 598501 taaagagaat tgatttgtat gatccggtac caagggagag cagaaccctt ggtatttttt 598561 tatgtattca ccacatatct aagaggcccc gttaataaga ttttatgatg gtttgactaa 598621 cgaataatgg gggttaaata tgtttatcca tatcgtcggg cctggtgatt ctttgttttc 598681 gataggcaga agatacggtg cttctgttga tcaaatacgg ggtgtgaatg gtttagatga 598741 aacgaatatc gtgccggggc aggctctgct tatccctctt tatgtatata cagtccagcc 598801 gagagatacg cttaccgcca ttgcagctaa agcgtttgtg ccattagagc gactgcgagc 598861 ggccaatccg ggcatcagcc caaatgcttt acaagcggga gcaaaaataa cgattccttc 598921 gatctcaaat tacattgcgg gaacgttaag tttttatgtg ctccgaaacc cagacctcga 598981 tcgggaatta atcaatgatt atgcgccata ctcgtcttcg atttcaattt tcgaatacca 599041 tattgcaccg aacggcgaca ttgcaaacca attgaatgat gcggccgcta ttgagacaac 599101 ttggcaaaga cgagtcacgc cgctggcaac aataacgaac cttacatcag gaggcttcag 599161 tacggagatt gttcaccaag tgctaaacaa tccgacagcg agaaccaatc tggtcaacaa 599221 catttatgac ttagtttcca caaggggata tggcggtgtc acaatcgatt ttgagcaggt 599281 gagcgccgcg gatcgcgatc ttttcactgg atttttacgc cagctgagag atcgacttca 599341 ggcgggaggg tatgtgctga cgatagctgt tcctgcaaaa acaagtgata atatcccatg 599401 gctgaggggc tacgattacg gggggatagg agcggttgtc aattatatgt ttatcatggc 599461 ttatgattgg catcatgcgg gaagtgagcc gggtcctgta gcgccgatta ctgaaataag 599521 gagaaccatt gagtttacga ttgcgcaggt gccgagcaga aaaatcatta tcggagtccc 599581 gctctacggg tacgactgga tcatcccgta ccagccgggc acagttgctt cagcgatttc 599641 aaatcaaaac gcaatcgaaa gagcgatgag gtaccaagcc ccgatacaat attcagccga 599701 atatcaatca ccgtttttcc ggtacagtga tcagcagggg cggacgcatg aggtatggtt 599761 tgaggatgtc agaagcatga gccggaagat gcagatcgtc cgtgaataca gattgcaggc 599821 tattggcgct tggcagttaa cgctgggctt tacgccgggc ccatggcttc tgcggaaatt 599881 ttttacgatc agaaaagtgt aaaaaaagac accagagctt gggtgtcttt tttttgatta 599941 agtccagagc agcagaatag ttcattcatt tgtaccttgc atgggttgtg ttcccatttt 600001 acgattagta gtagtctgat caaacaaaga gtcagaatac gatttgagag ggagttgtct 600061 acatgaagac agtattgatt ttgaattttc ctgcggaagg ccatgtgaat cctactttag 600121 gcattacgaa agcgttttcc gataagggat atgatgtcca ttatatatcc actgaaaaat 600181 ataaaaaacg attagaagca gcgggagcaa cggtccatct tcaccgggat ctgctgcgaa 600241 cgacacctat tcatgtcggt tcgcccaatg gcattcttga tttcgtgaaa atccatatca 600301 aaacgtcatt ggacatttta cagattgtca aagacttatc taagagcatt caatttgatt 600361 ttgtttatta tgataaattc ggcgcggggg aattggtgag ggattactta gatattccag 600421 gggtctcttc atcggcgtct ttcctgtttg gcgaggagca tctgaaaatc ctgccgctgc 600481 atccggagtc tggagcgccg cttgaattgg atcaagagtg cgaagacctt ttggcaaaaa 600541 tgaaagaaac gtacggtgtt gccccgaaaa acctggttca attcatgaac aataaagggg 600601 aattgaacgt agtgtataca agccgttatt ttcagccaga aagtgatcgt ttcggggatg 600661 aatgtctatt tatcgggccg agctttccaa agagagcgga aaaaacagat ttcccgattg 600721 aacagctaaa agatgagaag gtcatttata tttcaatggg gactgtactg gatcatacag 600781 aggatttctt caacctttgt attgatgcat tttcaggctt taacggaaaa gtcgtcatcg 600841 ctgccggaga aaaagcggac ctgaccaaat taaagcaggc gccggaaaac tttatcattg 600901 ctccgtatgt ccctcagctg gaagtgctgg agcaatcgga tgttttcatt acacacggcg 600961 gaatgaacag cgtaaacgaa ggcattcatt tcagcgtgcc actggttgtc atgcctcatg 601021 acaaggatca gccgatggtg gcgcagcgtc tctctgaact ccatgcaggc tatgtcatct 601081 ctaaagatga agtcaatgcc caaatattaa aacaggccgt agatgaggtt ttgcgcaacg 601141 atcagtatac ggcaggcatt aaaaaaatca atcaaagctt caaagaatgt atggacatgg 601201 aagaagtgat ggagcggatt gatgagttga ttcgccaaaa aaacaaataa gaaaaagaac 601261 tcccgtacct tgtacgggag ttcttgattt aaaacttgat tttgattttt tgagcatcac 601321 tgattttctt atggttatgg tcaaagacgt cacttgtcgt gatttcgatc cacttgatct 601381 cttttgtttt cttctcagca tccgcggcct tatcatgagc atggccgctt gatgcgttca 601441 caataaagcc gagatttccg gacttttcgg cgccgccttc caattcgccg tttaactctt 601501 caagataaat atctttgttc caatcaaagg tttcacccgt atttgttttc atcaatgcaa 601561 tcggcgcaac atttactttt tttgtagagg tgttcttgat atcaacgaaa accttaacga 601621 aatcaaactc ttcatcgtgt gttaactcat gaaagtaatc aatcatgctg tagtccgggc 601681 gcaagtggat cagcttcatt tcttttactg ttaactccac gtcgccaatt ttataggttt 601741 tgttcacttg tttgatatct tttaagacag cttttccttt atcatctgaa aacgtttggc 601801 cgaccttatg caatgtccgg tcatcagtta cctgggaatt aggctgataa tcatctgtgc 601861 tgtccttctg ggatgaagtg ctttgcggct cagcttttac tgttttctcc ccgcctgcat 601921 gctgtttttc agtactggcg tttgatgagc agcccgcaag catgatagca aaaacgagaa 601981 ttgaaagaat tcttctcatg atgattcctc cattaaaaag agatcccgtt acttcataca 602041 agcaacggga caccttgtat tcttttactt atcgttaatc ttaatgttgt attgtaaagc 602101 cttgaaaaca tttttggcga tttctgtatt gtcgatttgg ccggcaaatg tctcactaga 602161 cggaccgtat gcatagacgg gaacatcttc accggtatgt ccgcctgttg tccatccagt 602221 gtgagagcgt ttattaaaga tgttctcgat tgcgttatcg atatccagta cttccttcga 602281 ttttgccgct tcttcaacag attgaatttc ggcttttgtt aaagccaatt tcttttgatc 602341 gatatatgtt ttcaacgttt tttcaacatc cgcgccgtca gcgatctttt ctgccataaa 602401 gtctggtgtg cgctttgcgg ctttaatggg ttcactgaac cagttgtaga tgccgtccgc 602461 accgatggaa tatccgccgg ttgagtggtc agccgttgcg acaaccaatg tgtgcttgtc 602521 ttttttagcg aaatcaatag ccgccttata agcttgttcg aagtcttcca tctcgctcat 602581 ggcgccaacg atatcattgt catggcccgc ccagtcaatc tggctgcctt ccaccatgag 602641 gaagaatccg tctttatcct tgtttaattt tttaatggct gtgtttgtca tatctttaag 602701 tgatggaata tccttcgtac ggtcaatctt tttaggcagg ccgccgtcag cgaataggcc 602761 gagaacttgg ctgtctttgt ttttcagcat gtccttgcga tcatccacgt agctgtaccc 602821 cgcctttttg aattccttaa tcaaattacg gtccttacgg tcaaaattgc tctttcctcc 602881 gcctagaagg acatcaattt tgtgcttgcc gttgaccatc tcatcaaaat aatcatccgc 602941 aattgagttc atattttttc ggctgtggtc gtgtgaacca aaagaggccg gagtggcgtg 603001 tgtaatttct gaagtggcca caagtcctgt tgcttttcct ttttctttcg cagcttcaag 603061 caccgttttg gcttctgacc cgtcgttatc aacggctatg gcattattgt atgttttaat 603121 tcccgcagac atagccgttg ccgccgctgc agaatccgtt acattttgtt caggatcatc 603181 ggggtaagtt gtttgctggc cgacaagata ctgatcaaaa gccgtaggct ccacaacttt 603241 tgtcttttta ttatccttta agtatcgata agcagacgta taagacacac ccataccatc 603301 accaatcaga acaataacat ttttaatttc gtcttggttc ccctttttct tttcctgggc 603361 gctggcttca ggcacactgc cgctggctaa gctgctgaac gcaattgatg ataaaaccgc 603421 gataggcagt aatttcttcg ggaatttttt caactggata acctcctaaa tatagatgaa 603481 tctcaatgac aacccaatta tatttttaaa ctgttaagct agtattaatc gattttaaag 603541 attggattta caagaataat gaactggcac ccttaaataa tggttattct tttatgagaa 603601 gttttagaag gaaagagcga tagtactaaa gaaataaatt ggaggaatag atactggccg 603661 tggataggcg gactgaaatc tgctatagtc gcatagaagc aacccgctta catcttgaac 603721 aatttaaagt attacgttgg aaagaggtat tgtgtaagca catgtctgag cagttcatat 603781 ggagtggcat cattttattt taggagggaa caacatggac gttttttctg agtacttagc 603841 ggggattgct gacccgttcc accgagaaag aacggaagag gtgttaactt ggataaaaaa 603901 taaatatcca aatttacata cagaaataaa atggaatcag ccgatgttta cggatcacgg 603961 tacatttatt attggcttta gtgtttctaa aaagcattta gctgtcgctc ctgaaaaagt 604021 aacgatagcg cacgtagagg atgatattgt gaaggccgga tatgattaca ccgagcagct 604081 gatacgtatc ccttggaacg gtccagttga ttatacgcta cttgagaaaa tgattgagtt 604141 taatattctg gacaaggcgg actgctccac tttttggcgg aaatgaagaa aaaggcataa 604201 catatgagct gtataaaata tgttacgcct tttcatttgt ctatttttcg ttttgatcat 604261 ctattgctgc ttttcatcaa acaaggtctt ttcattgagc gtaagctgac tcgcagaata 604321 atgattacct tgtttccatt tcacttcaat cgtaatatca tggccttcaa gctcatgttc 604381 atctaaccgc tctaaaaaag aaacggactt ttcttttgcg cttccatcag aaaaagtgcc 604441 tccagcataa tcatgcatcg ggatttccgt gtcagaactc agcagaactt catcatcctt 604501 ttttacaatc agtgattcca gataagtgtt gtctatttca attgtatcac cgatccaata 604561 aagtttgccg ctgtattcat tcggtgcatc ttcatttttt gtgaaaacag cttcccaatt 604621 ctgatctttg ctttctccct gccaatttgg atactccaaa cgaacatgat gaatcaggtg 604681 ataggaaaaa aagatcaagc agaaagcgat taataggaat gccgtgaaaa tgagagggta 604741 tttataatga ctggacataa aagactccta ttcgtttaat caattacctt cgaaaataga 604801 atttcatccc gaatcaaaat gccgttttca gccacctcgg gaatctccgg cttgagtcgg 604861 cgcgcttttt caactgcgtt cggaaacact gcggcgaatt gatagcctct cttttgataa 604921 aacgctatcg catttacatt atcattcgtt gtgataagct ttattcgttg acaatgtgca 604981 tgtttagcct tctcttcaac ctgctgaagt aaagctgtgc cgattccttt attttcaatc 605041 atactatcta atgaaataat ttcacaatct ttcccatcta ttgtgtatgt aatacagcca 605101 atgatttcgc cgctttcatt tactgcggca aatccatcta attcatcaca ccgaaaaatg 605161 ccgctggaaa tcgccatctc gggtgtaccc caatgcttgg caaaaaaatc ggtcaacata 605221 tgtttcgcta tctcattgtt tgggatgatg atcatcataa cactcctcta ttgaaagatt 605281 gcatatgtac tatcaatata aacaatatat aacaaaaaaa atagatgttg aggtgacggc 605341 atggaaatca gcgatatcat ttacgggcag caccatatag acggagtgct ggaagagctt 605401 atcaaaagcg ctcctgtgca aagattaaaa ggaatctatc aaggcggagc aagcttttta 605461 gtcaatcgaa agtggaatgt gaccaggtat gagcactcca tcggcgtgat gctcctcatc 605521 aaaaagctcg gaggaacgat agaagaacag attgcgggtc tgctccacga cgtatcacac 605581 acagcttttt ctcatgtggt cgacgttgtc tttgaaaatc aagcagaaga ctatcatgaa 605641 aacatctttc aacaagtcat tgttcactct gaaatcccgg acattttaca aaaacacggc 605701 tatcatactg aagaactttt atctgacgat tcaaggtgga cattgctcga acagcccgca 605761 ccggagctgt gtgctgatcg gacagactat acgctgcgtg atatgtaccg atatggacac 605821 attaacctgc acgaagcgca aacctttttg gatcatctta ttgtgagaaa cggaaggatg 605881 tttcctgata gtattgaagc cgccgaatgg tttgtcagtg tgtactacaa ggaagtaatt 605941 gatttctttt tgaatcctgt gaatgtatat ggatatgaat atttagcgcg agcattgaag 606001 gcagcgctgc ggcatgatgt catatctgca gaggatctgc tgaaaacgga ccaagaggta 606061 ctgaacatcc tgcgtgcatc aaaaaatgaa gaagtcctga gcttgcttac atccattcat 606121 cccggcatac aagtaataga ggatgacatc cagtacgatt tccatcaaaa gaagaaaatg 606181 cgcctaatcg atccatccat ttttcttgat gacaaatgga tcaaatcctc aggtgtttct 606241 gaaaaggtga ggaaaatggg tgaggccgct tatcaaaaag caaaaaaagg tgtgtatata 606301 aaaatcttaa agcagtaatt gccgcctgac agcggctttt tttatgtttg gctttgcaaa 606361 caaaggggaa taggacaaac tgcgggaacg ctttatgaga atatcagcgt atttacatac 606421 cgttcggggg tatagtatta tcgagagggc atgttttcat tgtctgcggg caaaagttac 606481 aggaaaaaaa tgaagcaaag gagaatgaac atgaaaatct ctaaatatgc actgggaatt 606541 ctgatgttat ctctagtttt tgttttatca gcatgcggca ataacaacag tacgaaagaa 606601 agcacacatg acaatcattc agactcctca acacatgaag agatggacca ttccggatca 606661 gctgacgttc cagagggatt acaggaatct aaaaatccga aatacaaagt aggcagccaa 606721 gtaatcatca atacttctca tatgaaaggc atgaaaggtg ctgaagctac ggtaacaggc 606781 gcctatgata caacggcgta tgttgtttct tatactccga ctaatggggg acagcgtgtg 606841 gatcatcaca aatgggtgat ccaagaagaa atcaaagatg ccggagataa aacgttacaa 606901 cccggagatc aggtgatttt agaggcttct catatgaaag gcatgaaagg agcaacagcc 606961 gagatcgatt ccgcggaaaa aacaactgta tacatggttg actacacatc gacaacgagc 607021 ggcgaaaaag tgaaaaacca caaatgggtc acagaagatg agctttcagc taaataataa 607081 aaaatcctcc ttttacaagg aggatttttt tgctgtttga acaggtcttg ttaaagaaat 607141 gaaagcaaac aggacagcga tgatcacaat cgatccgccg caccatgccg ttgacaccac 607201 agtacccgtc tgatccaaaa caacaccgcc aatggctgag ccaagggcaa ttccgacttg 607261 gagggccgat gtgttaaagc tttgctgaat gtcagacgaa tcaggtgcaa tttcaattaa 607321 atagctttgc tgagccgggg cgaggctcca gctcagaaga ccccaaatca ccatgacagg 607381 caaaaagaaa atcatagacg atgtagacag cggcagtaag aacataatga tggcaaagga 607441 accggtcacc agcaaaatgc tcttaaagga accaagccgg tcagatagcg ctcctccgaa 607501 agggcctccg catacagcag atatcccgaa aaggaaataa caaatgctga cccagaaaga 607561 gctcaggtga agagtctctt ctaaaaacgg cgcaaagtaa gcgtaaagcg tgtagtggcc 607621 agctaatgta aacatcgtga cgaggtgtga actcgcgatt ttcagattac cgatcgtctt 607681 gagttgttcc cggaaaggaa tcattttctc cgccggtatt ctttcaaaga agattgaaat 607741 aatcagcatg gagatcagtg ccaacaggcc gatgccaagg aacaaaatcc gccacccgaa 607801 ggaatcgctg attaagattc cgagcggcac gcctaatgcg atagcagagc tgaatcccat 607861 aaaaataatt ccgattgcgc gggctctgta ttcaggcgct acaattttcg gggcaattgt 607921 taaagaaagc acaacaatca gccctgtact cattgctgcc aataccctag ataccatcag 607981 tgttgcgaaa ttagggctga aataggcgac aagattgcta aggaagaaaa caaataaagc 608041 aattagatat aagcgcttcc gctcaatctt cgcagtcaat gccaaaagca gcggcccaga 608101 tactgcatat cccagcgcaa acacactgat cagctgtccg gctgaaacaa tggaaatgtc 608161 taaatcattt gcgatctgag gaagaattcc ccccacaatt aactcaacca atccgactgc 608221 aatcgtagaa gctgcaagca ggaaaacttt gaaattcata acaaactcct ttacttaaat 608281 gttttgataa ataaaaaaaa tcctgattac aaaaaatgtc ataaacaaat tttgtaatca 608341 ggattttacg gttcctggta gacaccctca aaccatatta ttgaggttat acaagtgata 608401 atagctattt aattgattcg tttccgttga tgagtgtacc acattatgaa tgaatcttcc 608461 atagaaaaat ttataaaacg gtgaaccgga aaaaaatatg attatattta ttttataaaa 608521 gtatagacat ttaaaattaa atgactataa taatcaatgt aagcgtttta ataacagggg 608581 ggatagcagt tgaaaaaaat attactcgcg tgcagttcag gaatgtctac cagtttattg 608641 gtgacaaaaa tgaaggaata cgcacagtct atcggtgagg aagcggagat ttgggctgtt 608701 ggccaggata aagcaaaaga agacatgaga aaagcggatg ccgttttgat cggtccgcaa 608761 atgagctttc tgaaaagcga gctccaaaaa gaagcagatc aatacaacat tcaagttgaa 608821 gtcattgaca tgatggccta cggaatggca gatgggaaaa aagcgtatga gcaggcattg 608881 tccttaatgg tgaatcaata atggaacaga tgaaaatcac gaatttaaca gacgagcaaa 608941 tcagttttca gctaatcctg cacagcggaa atgcccgcag ctgcatcata caatcactgc 609001 gcgcctataa agaagggaaa aaggacgagg ctgatgccct cattgccaag gcggagcagg 609061 atttatccgc ggcccatgac attcactttc aaatgataca gaaggaatcc ggcggagaag 609121 caacagcttt ttcattgctg cttatgcatg cagaggatca tctgatgtca acattatcca 609181 tgaaagaatt agtgaaagag atgcttgatc tctttaaaac caagaatata taaaaaatcg 609241 gggtggatag ggtgttcgag aaaatcagcc aattccttgt tccaattgca gggaggttaa 609301 acaataaccg ctatttgcaa gtgttgcgtg atgcatttat gctggctttc ccgctgacga 609361 tattcgggtc catttttgtc gtgttaacga atttgccgtt tctaaacaaa atcatgaacg 609421 cctcaatgct tacgtcgttt cagtctcatt tcggcattgc ctccacggcg acaatgggca 609481 ttatgtctgt ctttgttgtg ttcgggatag gctattacct gtcgaaaagc tatcaggtcg 609541 aagctgtatt tggcggagcg atcgctttgg tttccttttt gctcttaacg ccatttatca 609601 ttcagccgga aacaggtgat gccattacag gggttatccc ggtcgatcgt ctcggtgcaa 609661 aagggatgtt tcttgggatg attacggcat ttctttctgg cgaaatttac agaagaatcg 609721 ttcaaaaaaa cctgacaatc aaaatgccag ccggcgttcc gcctgctgta gcaaaatcat 609781 tcgccgcact tattccggct tttatcacat tgactgtatt tttgctgatt aacgtaatgg 609841 tgactctgtt ttttaaaaca aatatgcacg acgtcattta tcatgcgatt caggctccgc 609901 ttgtcggact tggaagcggt atcattccaa cactgattgc cgtgtttttc attcaaattc 609961 tttggttttt cggactgcat ggacagatca ttatcaactc cgtgatggac ccgatttgga 610021 atacactgca ggtagaaaac ctttctgctt acacggcggg aaaagaaatc cctcatatta 610081 tttcaaaacc gtttatggag atttatacag tagggatggg cggaacaggg atgacgcttg 610141 cgattgtgtt taccattctc atattcatga aaagcaggca gatgaagcaa gtatcaaaac 610201 ttggcctcgc tcccggtatt tttaacgtaa acgaaccgat tatctttggg cttccgattg 610261 tcatgaatcc gatcattatt gtgccttggg tgctggcacc gatggttgtt acgctcgtca 610321 cctatctggc tatgtcagcc gggctcgttc cgcctccaac tggtgtgaca gtgccgtgga 610381 cggttccatt attcattaat ggcatcatgg cgacgaactc aatcatgggg ggcgtgatgc 610441 agcttatcaa tctgctgatt gtcttcgtga tctggtttcc gttcctaaaa gcaatggata 610501 aattaaatct ggcaaaagaa aaagaacagg ctgtgcagga gacagctgct cagcaaaatg 610561 ataacagcat aaaaatgtga cataagggga gagagacttg gcacatacag aacaatatcg 610621 ttttccaaag gatttttggt ggggatcatc cgcttcagca acacaaatgg agggtgccgc 610681 cgacagagac ggaaaaggcc agaatatatg ggattattgg tttgaaaaag aaccgcatcg 610741 tttttttgat catgtcggac ccgcagacac atcccaattt tacgacaact ataaagaaga 610801 tatcaggctg atgaaggaac ttggccacaa ctcgttccgg atgtcgattt cctggtcacg 610861 tttaatacca aacggaacgg gcgagatcaa cgataaagcc gcagatttct ataacaatgt 610921 cattgatgag ctgatcgcta acggaattga accttttgtc aatttgtttc atttcgatat 610981 gccgatggcg cttcaaaaaa tcggcggctg ggtcaacaga gagacggttg acgcgtatga 611041 aaactatgca agaacttgct tccgtttgtt tggcggccgg gtgaaaaaat ggttcacgca 611101 taatgaacca atcgttcccg tagaaggcgg atacctatat gattttcatt atccaaacaa 611161 ggtcgatttt aaagaggccg tccaggttgg atttcatacg atgctatcaa gtgcccgcgc 611221 cattcaggct tacagggaga tgaagcagga cggaaaaatc ggcatcatct taaatttgac 611281 cccttcatac ccgagaagca gccatccggc ggatgtgaaa gccggggaaa tcgcagacgc 611341 gttttttaac agatcttttt tagacccatc tgtcaaaggc gaatttccca aagagctggt 611401 tgacattttg aagcatgaag gctttatgcc tgattacaac gctgaagatc tcgacatcat 611461 caaaaagaac acggttgacc tgttgggagt gaattattac cagccgagac gtgtgaaagc 611521 gaaagaacat cttccgaatc ccgacgctcc ttttttgccg gacaggtatt ttgatcccta 611581 cgtcatgccg ggccgcaaaa tgaatccgca tcgcggctgg gagatctatg aaaaaggcgt 611641 ttatgatatt ttgatcaatt taaaagaaaa ctacggcaac atcgagtgtt ttatctctga 611701 aaacggtatg ggggttgaag gtgaagagcg attcagggat gaacaaggca tcattcagga 611761 tgattaccgg attgaattta taaaagagca cctcaaatgg attcaccgcg ccatacagga 611821 aggctcgaac gtaaaaggct atcacttatg gacgttcatg gacaactggt cttggacaaa 611881 tgcctataaa aaccgatacg gatttgtatc agtcaatctt gagaaagacg gagaaagaac 611941 cgtcaaaaag agcggaaaat ggttcaaaga ggttgctgag catagcggtt tctagatttt 612001 cctaaaggtc aagatcttcc ggcaatcatc ataacgaata gagatgacga aaatccgcaa 612061 cattgatgaa atagggaaaa gaacttatga tatccgtaaa agcttatgtg atatcaaaca 612121 gctgccggag gataccaatg aataaatacg aaatcattgc aaatgaaatg agaaatagaa 612181 ttaaaaataa cgtatatccg atcgatcagc ccattcctga tgaagtatct cttgcaaaag 612241 aatttaactc aagccgcatg acgatgaaga gagccttgga taatttagtt gccgagggtc 612301 tgctgtttag aaaacgaggc catggcacgt ttattattca atctgcaata caggatgacc 612361 atgtccatgt agtcagcaat gagattctcg gattgaccaa cttgctgaaa gataaaaaaa 612421 tcaaaagcaa ggtcattcag tttgaagtgc aatttcccac tgaggaagtg gccgcccatt 612481 tgtctattga tcagaaaaca ccggtttatt atgtcgttcg gctgcgaatt gtagaaggtg 612541 aaccctatgt attagaaaaa acatatatgc cgactcattt aataccgggc attaatgacg 612601 atgtccttca tgattcgatc tacaatcata ttacaaatgt gctgcagctc aaaatcgccg 612661 gaacgcatcg gaaaatcaga gcctgcaaat ctgatcatat tgaccagcag catctgggct 612721 gtaaacagga tgatccaatt cttgaagtgg aacatgtggg cttcttagat accgggattc 612781 catttgaata ttccttttca cgtcatcggc atgacaagtt tgttgtgact tctgtaaaca 612841 tacggcgctg attgcggaga caacaaggag gccatctgca tgcttggcgg tattgaagca 612901 ggcggcacaa agtttgtttg tgctgtcggt agagaagatg gaacgatcat tgacaggata 612961 gaattcccca caaagatgcc ggatgaaacg atagagaaag taattcaata ttttagccaa 613021 ttttcattac aggcaatcgg catcggctcc tttggtcccg ttgataacga taaaaccagt 613081 caaacatacg gtaccattac ggccacgccg aaagcgggct ggagacacta tccctttttg 613141 caaaccgtta agaacgaaat gaagatccca gtcggattta gtacagatgt caacgctgcg 613201 gcgctgggtg aattcctttt cggtgaagcg aagggtcttg acagctgcct gtatataacg 613261 attggcactg gcatcggagc gggggctatt gtagagggga ggctccttca ggggctgtca 613321 cacccagaga tgggccatat ttatatccgg aggcacccgg atgacgtata ccaagggaag 613381 tgcccttatc atggagattg ctttgaaggc ttagcttcag gccccgctat cgaagcccgc 613441 tgggggaaaa aagccgcgga tttatcagat atagcacaag tctgggaact ggaagggtac 613501 tatattgccc aagcactggc tcagtatatt ttgatccttg cacctaaaaa aatcattctt 613561 ggcggcggcg tcatgcaaca gaaacaagtg ttttcttata tctatcaata tgtaccaaaa 613621 atcatgaaca gctacttaga tttttctgaa ttatcagatg atataagtga ttatattgta 613681 cctccacgtt taggcagtaa cgccggaatc atcggcacgc tagttttagc gcatcaggcc 613741 ttacaagcag aggcagcatc cggggaggtg cgatcatgac gcatccatta tttttagagc 613801 ctgtctttaa agaaagacta tggggaggga cgaagcttcg tgacgctttt ggctacgcaa 613861 taccctcaca aaaaacaggt gagtgctggg ccgtttctgc acatgcccat ggctcgtcgt 613921 ctgtaaaaaa tggcccgctg gcaggaaaga cacttgatca agtatggaaa gatcatccag 613981 agatattcgg gtttccggat ggtaaggtgt ttccgctgct ggtaaagctg ctggacgcca 614041 atatggatct ctccgtgcaa gtccatcctg atgatgatta tgcaaaactg cacgaaaatg 614101 gcgaccttgg taaaacggag tgctggtata tcattgattg caaagatgac gccgaactaa 614161 ttttgggaca tcatgcaagc acaaaggaag agttcaaaca acgaatagaa agcggtgatt 614221 ggaacgggct gctgaggcga atcaaaatca agccaggaga tttcttttat gtgccaagcg 614281 gtacactcca tgctttatgt aagggaaccc ttgtccttga aatccagcaa aactctgata 614341 caacatatcg cgtatacgat tatgaccgct gtaatgacca gggccaaaaa agaactcttc 614401 atatagaaaa agccatggaa gtcataacga taccgcatat cgataaagtg catacaccgg 614461 aagtaaaaga agttggtaac gctgagatca ttgtttatgt gcaatcagat tatttctcag 614521 tgtacaaatg gaagattagc ggccgagctg cttttccttc atatcaaacc tatttgctgg 614581 ggagtgttct gagcggatca ggacgaatca taaataatgg tattcagtat gaatgcaatg 614641 caggctcaca ctttattctg cctgcgcatt ttggagaatt tacaatagaa ggaacatgtg 614701 aattcatgat atctcatcct taatgaatgg gggagttgca tttgtttaag aaacatacga 614761 tctctttgct cattatattt ttacttgcgt ctgctgtttt agcaaaacca attgaagcgc 614821 atactgtgtc gcctgtgaat cctaatgccc agcagacaac aaaaacagtg atgaactggc 614881 ttgcgcacct gccgaaccga acggaaaaca gagtcctttc cggagcgttc ggaggttaca 614941 gccatgacac attttctatg gctgaggctg atagaatccg aagcgccacc gggcaatcgc 615001 ctgctattta tggctgcgat tatgccagag gatggcttga aacagcaaat attgaagatt 615061 caatagatgt aagctgcaac ggcgatttaa tgtcgtattg gaaaaatggc ggaattccgc 615121 aaatcagttt gcacctggcg aaccctgctt ttcagtcagg gcattttaaa acaccgatta 615181 caaatgatca gtataaaaaa atactagatt cttcaacagt agaaggaaag cggctaaatg 615241 ccatgctcag caaaattgct gacggacttc aagagttgga gaaccaaggt gtgcctgttc 615301 tgttcaggcc gctgcatgaa atgaacggcg aatggttttg gtggggactc acatcatata 615361 accaaaagga taatgaaaga atctctctat ataaacagct ctacaagaaa atctatcatt 615421 atatgaccga cacaagagga cttgatcatt tgatttgggt ttactctccc gacgccaacc 615481 gagattttaa aactgatttt tacccgggcg cgtcttacgt ggatattgtc ggattagatg 615541 cgtattttca agatgcctac tcgatcaatg gatacgatca gctaacagcg cttaataaac 615601 catttgcttt tacagaagtc ggcccgcaaa cagcaaacgg cagcttcgat tacagcctgt 615661 tcatcaatgc aataaaacaa aaatatccta aaaccattta ctttctggca tggaatgatg 615721 aatggagcgc agcagtaaac aagggtgctt cagctttata tcatgacagc tggacactca 615781 acaagggaga aatatggaat ggtgattctt taacgccaat cgttgagtga atccgtaatg 615841 tcacaattaa gaaggtgctc aagaagtttc ttgagcacct tcccactgga ttaagcattc 615901 atatcgccta acccaggact gtgttcattt ggtatttcag gaagcactgg tacgggaaac 615961 cctgccggag gatctattac ttgtaactct ccgccatttc ggcttggaga tttcccttga 616021 tagatttcac tgattctcgt ttcatccaac ctaaagttaa aatgtgtatt atggtagcct 616081 aattcgacat actttctgca ctcaggatat ttattaatgt cataattcgg cacagggagc 616141 agcttcgccc attcaacgcc caatgtctcg agcgctttcg cgaatgcatt ctggtgagca 616201 ttgtcgcgta caatcagaaa agcaagtgtt tcgcggaacg tctgattaga gctcatttca 616261 taaattcttg ttttttgcag cacacctgtc gactcaagaa gcaggttatc cagcaggtca 616321 gtaattaagt ttccgtggtt atacacccac gacccgttcc acggattgcc ccctgcatca 616381 acaggaaggg aactttgcgc tccaataata taatgatgag gattagcatg tttaaccgct 616441 tcatcaagtg gcgcttgatc tgtaccttga ctgccgacac cttcaccgcc tgattcatct 616501 aataaagcat tgattgtgtt ttgaaccagt tcaacgtggg caatctcctc taaaaaaatg 616561 ccgcgaagca gatcgcggta ctgtttctgc tttcctctga aattagagct ttggaaaaaa 616621 actgcatcat tgtacgcatt tctccgtaat gaccgcctaa tatctcctgc aggaccttag 616681 cagctgccgg gtctggcttg tccggtttaa tgatattaat cagttcctct ttgtagtaat 616741 acataacacg cctcatttct tcttaagaga ttttcttata ttatttgtaa gatgagataa 616801 aatatataca tgataagcat gggaaggcgt gaaagaagaa aataaaaaaa tacaggaaaa 616861 gtgttgacca aataaaacag gcatggtata ttattaaacg tcgctgatga acagcgtgaa 616921 acaaaacaga aaaacaaaaa agttttccta aggtgtttac aagattttaa aaatgtgtat 616981 aataagaaaa gtcgaattga aaaagattcg aaaaaacatt aaaaaacttc ttgacttcaa 617041 catcaaatga tagtatgata gttaagtcgc tcaataagcg cccgtagctc aattggatag 617101 agcgtttgac tacggatcaa aaggttaggg gttcgactcc tctcgggcgc gccatataag 617161 ataccacgcg ggtgtagttt agtggtaaaa cctcagcctt ccaagctgat gtcgtgagtt 617221 cgattctcat cacccgctcc attattgaat gatctttgaa aactaaacaa gacaaaacgt 617281 acctgttaat tcagtttttg aaaatcgcac agcgatgtgc gtagtcagtc aaactagggc 617341 ctgcacgatg caggtcacac aggtgtcacc gcgggatgcg gtggacttaa cctgtgatcc 617401 atttatcgga gagtttgatc ctggctcagg acgaacgctg gcggcgtgcc taatacatgc 617461 aagtcgagcg aacagatggg agcttgctcc ctgatgttag cggcggacgg gtgagtaaca 617521 cgtgggtaac ctgcctgtaa gactgggata actccgggaa accggggcta ataccggatg 617581 gttgtttgaa ccgcatggtt caaacataaa aggtggcttc ggctaccact tacagatgga 617641 cccgcggcgc attagctagt tggtgaggta atggctcacc aaggcaacga tgcgtagccg 617701 acctgagagg gtgatcggcc acactgggac tgagacacgg cccagactcc tacgggaggc 617761 agcagtaggg aatcttccgc aatggacgaa agtctgacgg agcaacgccg cgtgagtgat 617821 gaaggttttc ggatcgtaaa gctctgttgt tagggaagaa caagtaccgt tcgaataggg 617881 cggtaccttg acggtaccta accagaaagc cacggctaac tacgtgccag cagccgcggt 617941 aatacgtagg tggcaagcgt tgtccggaat tattgggcgt aaagggctcg caggcggttt 618001 cttaagtctg atgtgaaagc ccccggctca accggggagg gtcattggaa actgggaaac 618061 ttgagtgcag aagaggagag tggaattcca cgtgtagcgg tgaaatgcgt agagatgtgg 618121 aggaacacca gtggcgaagg cgactctctg gtctgtaact gacgctgagg agcgaaagcg 618181 tggggagcga acaggattag ataccctggt agtccacgcc gtaaacgatg agtgctaagt 618241 gttagggggt ttccgcccct tagtgctgca gctaacgcat taagcactcc gcctggggag 618301 tacggtcgca agactgaaac tcaaaggaat tgacgggggc ccgcacaagc ggtggagcat 618361 gtggtttaat tcgaagcaac gcgaagaacc ttaccaggtc ttgacatcct ctgacaatcc 618421 tagagatagg acgtcccctt cgggggcaga gtgacaggtg gtgcatggtt gtcgtcagct 618481 cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca acccttgatc ttagttgcca 618541 gcattcagtt gggcactcta aggtgactgc cggtgacaaa ccggaggaag gtggggatga 618601 cgtcaaatca tcatgcccct tatgacctgg gctacacacg tgctacaatg gacagaacaa 618661 agggcagcga aaccgcgagg ttaagccaat cccacaaatc tgttctcagt tcggatcgca 618721 gtctgcaact cgactgcgtg aagctggaat cgctagtaat cgcggatcag catgccgcgg 618781 tgaatacgtt cccgggcctt gtacacaccg cccgtcacac cacgagagtt tgtaacaccc 618841 gaagtcggtg aggtaacctt ttaggagcca gccgccgaag gtgggacaga tgattggggt 618901 gaagtcgtaa caaggtagcc gtatcggaag gtgcggctgg atcacctcct ttctaaggat 618961 attatacgga atataagacc ttgggtctta taaacagaac gttccctgtc ttgtttagtt 619021 ttgaaggatc attccttcga aacgtgttct ttgaaaacta gataacagta gacatcacat 619081 tcaattagta atacaagata tcacatagtg attcttttta acggttaagt tagaaagggc 619141 gcacggtgga tgccttggca ctaggagccg atgaaggacg ggacgaacac cgatatgctt 619201 cggggagctg taagcaagct ttgatccgga gatttccgaa tggggaaacc caccactcgt 619261 aatggagtgg tatccatatc tgaattcata ggatatgaga aggcagaccc ggggaactga 619321 aacatctaag tacccggagg aagagaaagc aaatgcgatt ccctgagtag cggcgagcga 619381 aacgggatta gcccaaacca agaggcttgc ctcttggggt tgtaggacac tctgtacgga 619441 gttacaaagg aacgaggtag atgaagaggt ctggaaaggc ccgccatagg aggtaacagc 619501 cctgtagtca aaacttcgtt ctctcctgag tggatcctga gtacggcgga acacgtgaaa 619561 ttccgtcgga atccgggagg accatctccc aaggctaaat actccctagt gaccgatagt 619621 gaaccagtac cgtgagggaa aggtgaaaag caccccggaa ggggagtgaa agagatcctg 619681 aaaccgtgtg cctacaagta gtcagagccc gttaacgggt gatggcgtgc cttttgtaga 619741 atgaaccggc gagttacgat cccgtgcaag gttaagcaga agatgcggag ccgcagcgaa 619801 agcgagtctg aatagggcgc atgagtacgt ggtcgtagac ccgaaaccag gtgatctacc 619861 catgtccagg gtgaagttca ggtaacactg aatggaggcc cgaacccacg cacgttgaaa 619921 agtgcgggga tgaggtgtgg gtaggggtga aatgccaatc gaacctggag atagctggtt 619981 ctctccgaaa tagctttagg gctagcctca aggtaagagt cttggaggta gagcactgat 620041 tggactaggg gcccctaccg ggttaccgaa ttcagtcaaa ctccgaatgc caatgactta 620101 tccttgggag tcagactgcg agtgataaga tccgtagtcg aaagggaaac agcccagacc 620161 gccagctaag gtcccaaagt atacgttaag tggaaaagga tgtggagttg cttagacaac 620221 caggatgttg gcttagaagc agccaccatt taaagagtgc gtaatagctc actggtcgag 620281 tgactctgcg ccgaaaatgt accggggcta aacgtatcac cgaagctgcg gactgttctt 620341 cgaacagtgg taggagagcg ttctaagggc tgtgaagcca gaccggaagg actggtggag 620401 cgcttagaag tgagaatgcc ggtatgagta gcgaaagagg ggtgagaatc ccctccaccg 620461 aatgcctaag gtttcctgag gaaggctcgt ccgctcaggg ttagtcggga cctaagccga 620521 ggccgaaagg cgtaggcgat ggacaacagg ttgatattcc tgtaccacct cctcaccatt 620581 tgagcaatgg ggggacgcag gaggataggg taagcgcggt attggatatc cgcgtccaag 620641 cagttaggct gggaaatagg caaatccgtt tcccataagg ctgagctgtg atggcgagcg 620701 aaatatagta gcgaagttcc tgattccaca ctgccaagaa aagcctctag cgaggtgaga 620761 ggtgcccgta ccgcaaaccg acacaggtag gcgaggagag aatcctaagg tgatcgagag 620821 aactctcgtt aaggaactcg gcaaaatgac cccgtaactt cgggagaagg ggtgctctgt 620881 tagggtgcaa gcccgagaga gccgcagtga ataggcccag gcgactgttt agcaaaaaca 620941 caggtctctg cgaagccgta aggcgaagta taggggctga cgcctgcccg gtgctggaag 621001 gttaagagga gcgcttagcg taagcgaagg tgcgaattga agccccagta aacggcggcc 621061 gtaactataa cggtcctaag gtagcgaaat tccttgtcgg gtaagttccg acccgcacga 621121 aaggcgcaac gatctgggca ctgtctcaac gagagactcg gtgaaattat agtacctgtg 621181 aagatgcagg ttacccgcga caggacggaa agaccccgtg gagctttact gcagcctgat 621241 attgaatgtt ggtacagctt gtacaggata ggtaggagcc ttggaaaccg gagcgccagc 621301 ttcggtggag gcatcggtgg gatactaccc tggctgtatt gaccttctaa cccgccgccc 621361 ttatcgggcg gggagacagt gtcaggtggg cagtttgact ggggcggtcg cctcctaaaa 621421 ggtaacggag gcgcccaaag gttccctcag aatggttgga aatcattcgc agagtgtaaa 621481 ggcacaaggg agcttgactg cgagacctac aagtcgagca gggacgaaag tcgggcttag 621541 tgatccggtg gttccgcatg gaagggccat cgctcaacgg ataaaagcta ccccggggat 621601 aacaggctta tctcccccaa gagtccacat cgacggggag gtttggcacc tcgatgtcgg 621661 ctcatcgcat cctggggctg tagtcggtcc caagggttgg gctgttcgcc cattaaagcg 621721 gtacgcgagc tgggttcaga acgtcgtgag acagttcggt ccctatccgt cgcgggcgca 621781 ggaaatttga gaggagctgt ccttagtacg agaggaccgg gatggacgca ccgctggtgt 621841 accagttgtt ctgccaaggg catcgctggg tagctatgtg cggacgggat aagtgctgaa 621901 agcatctaag catgaagccc ccctcaagat gagatttccc attccgcaag gaagtaagat 621961 ccctgaaaga tgatcaggtt gataggtctg aggtggaagt gtggcgacac atggagctga 622021 cagatactaa tcgatcgagg acttaaccat atttttgaat gatgtcacac ctgttatcta 622081 gttttgagag aacactctca atttgtttgg tggcgatagc gaagaggtca cacccgttcc 622141 cataccgaac acggaagtta agctcttcag cgccgatggt agtcgggggt ttccccctgt 622201 gagagtagga cgccgccaag cattactttt atcatcgcgg ggtggagcag ttcggtagct 622261 cgtcgggctc ataacccgaa ggtcgcaggt tcaaatcctg cccccgcaac caaatatatg 622321 gttaaataag gagtgcccta agggtgcaac caaaataatc ctatacaaat atggtccggt 622381 agttcagttg gttagaatgc ctgcctgtca cgcaggaggt cgcgggttcg agtcccgtcc 622441 ggaccgccat taatgtaaac gaaacgatca tgttttcgtt ttttttgtgt tttcttttac 622501 tgtatcttct gcttggtgtc atagccaagc tttctttata tcgggaacat cttggatatt 622561 ccagcaaaat tcgataaact aggaagagca caaataggca taagcagggt tgaaaggagg 622621 ttttggttca tggatgaatt tgatttgata catagcatta ctccgcggac cattcaccat 622681 tcttccgttg atgtaggaat aggtgatgat gcagcgctct acactgcgaa acacggcgtt 622741 caggaaattg tttgtgttga tactatggta gaagacgtgc acttcaaatt acactattcc 622801 tcacctgaag atatcgggta caaggcgtta gccgttaata taagtgatat tgccgcgatg 622861 ggaggcattc ctaagtttta tctggtatca cttgcggtac cttcaaaatg gactgaatct 622921 gaaatcaagg cgatgtatga aggaatgaat gaactggcga aactatatca tatggatctg 622981 attggcggcg atacagtttc taccgctgac aaattagtcg ttacagtcac tgtaatcggt 623041 gaaattgaaa agggacaggc ctgtttgcgc agcttggcaa aaccgaatga tattgtgttt 623101 gtaaccggtg aaatcggttc ttctgcagca gggctttctt tattgctgga agagactaat 623161 cctcaaaact catctgtgga aacggattac tttatccaca ggcataaacg gcctgagcca 623221 agagtaagcg tcggcagatt atgctcgatt tttaaacggg cagctttaaa tgatgttagt 623281 gacggattgg ctagtgaact gaacgagatt gcagaagcca gctgtgtttc aattgaaatt 623341 gttgaaagca tgcttccaat tcattctgat ttgcctaagc ttcatcctaa ctggaaagaa 623401 tgggctttgt ttggcggtga ggattttgag ctgacaggga cggtttcaaa tgaggagtgg 623461 gaagtgttga agcaggagtg cgcagcgctt catcttccca ttacaaagat tggctatgtc 623521 agggaaaaaa caaaatctaa agtgatccta aaaacagatc aaacatcaat gatcttagag 623581 aaaaagggat ataatcattt taaataagac gggtgactcg tgtgaagcaa ttaaaatgga 623641 gaactgtaaa tccagaagaa acaaaagcaa ttgccaagct gacggcagcg tttgctaaac 623701 cgggagacgt cctgacatta gagggcgatt taggtgcagg aaaaacgact tttacgaaag 623761 gttttgcaga agggctggga attacacgta ttgtaaacag tccgactttt acaattataa 623821 aagaatataa cgatggcgta cttcctcttt atcacatgga tgtgtataga atggaagatg 623881 aaagtgaaga tttgggactt gatgaatatt ttcacggaca aggtgtctgt ctcgttgaat 623941 gggctcattt aattgaagaa cagctgccac aggagcgact gcaaattgtc atcaaaagag 624001 ctggtgatga tgagcgggaa attaccttta ctgctgtcgg gaatcggtat gaaatgcttt 624061 gtgaggagtt aagtagacat gacaatatta gcaattgata catcaaatta tacattgggc 624121 attgcgctgc ttcgagaaga cactgttata gcagaataca ttacatattt gaaaaagaac 624181 cactctgtaa gagcgatgcc tgctgttcat tcattgctga atgattgtga tatggcaccg 624241 caggaccttt ctaaaattgt cgttgcaaaa ggccctggtt catacacagg agtaagaata 624301 ggtgtgacgt tggccaaaac acttgcctgg tctttagaca ttccaataag tgctgtatca 624361 agtcttgaga cgcttgcggc aaatggccgg cattttgacg gtctgatcag cccaatcttt 624421 gatgctagac ggggacaggt gtacacaggt ctgtatcaat ataaaaatgg gcttttagag 624481 caagttgttc cagatcaaaa tgtgatgctg gcagattggc tggagatgct aaaagaaaag 624541 gaccgccctg ttttgttttt aggccatgat acttctcttc acaagcagat gatcgaggat 624601 gtgcttggaa caaaaggatt cattggaact gccgcccagc ataacccgcg cccttcagaa 624661 ttggcttttc tcgggaagga aaaggaagca gctgatgttc atgggcttgt cccggattac 624721 ttgcggctgg cagaagctga agcgaaatgg attgaaagtc aaaagtaggg tgataggatg 624781 aaaacaaaag cagcggtcag aaatatgcgg cttgaagata tagatcacgt atacgaaatc 624841 gaagcatcct cctttacgtc tccttggacg aaggattcgt tttatcatga gctgctggaa 624901 aatccgtatg ctcattatct cgtgattgaa aaggacggcc atcttgctgg gtattgcggg 624961 atttggattg tgatggacga tgcccagatt acaaatatag cgataaaacc agagtatcgc 625021 ggccagtctt taggagaaac gctttttcgc tcagctgttg aactgtgcaa agaaaaagac 625081 gcaaggcggc tttcgcttga agtgagggtt tcgaatcatc ctgctcaagg cttatataag 625141 aaattcggga tgcagcccgg cggaataaga aagaactatt atactgataa cggggaagat 625201 gcgttaatta tgtgggtgac gataaatgag tgagcaaaaa gacatgtacg tattaggaat 625261 tgaaacaagc tgtgatgaga ctgctgcagc tattgtgaaa aacgggaaag agatcatttc 625321 aaacgtagta gcctctcaaa ttgaaagcca taagcgcttc ggaggcgttg ttccggaaat 625381 tgcttcaaga catcatgttg aacaaatcac tttggttata gaagaggcgt ttcgcaaagc 625441 tggcatgacg tatagtgata ttgatgcgat tgcagtaaca gaaggtccgg gactggtggg 625501 agcgcttctt atcggagtga atgccgctaa agcattgagc tttgcatata acattccgtt 625561 agtaggcgtt catcatatag ccggtcatat atacgcgaac cgtcttgtag aagacatcgt 625621 gttcccggca ctggcattgg tcgtttcagg aggccataca gaactggttt atatgaagga 625681 acatggatca tttgaagtca ttggggaaac ccttgatgat gcggcaggag aagcctacga 625741 caaagtggcg cggacgatgg gattgccata tccgggtgga ccgcaaattg acaagctagc 625801 tgaaaaaggg aatgacaata ttccgcttcc tcgcgcatgg cttgaagaag gctcttacaa 625861 cttcagcttt agcggattga agtctgcggt gatcaatacg cttcataatg catcccaaaa 625921 agggcaagag attgctccgg aagatttgtc tgccagtttc caaaatagtg tgatcgatgt 625981 cttggtaacc aaaacggcgc gcgcggcaaa ggaatatgat gtcaaacagg tccttttagc 626041 cggaggagta gctgcaaaca gaggcctcag agctgcatta gaaaaggaat ttgcccagca 626101 tgaagggatt acgcttgtca ttcctccatt agctttatgc acggataatg ctgcgatgat 626161 tgctgctgct ggtacaattg cttttgaaaa aggaattcgc ggtgcatatg atatgaatgg 626221 ccagcccggc cttgaattga cttcttatca aagtctcacg agataatagc gtgagacttt 626281 ttatctgttt gttattaaca gacaattcac aatttatcca catatctgtg agtaattata 626341 gagatattga tggataaagg gctgaggtca ctgttaataa agtggataaa ttcagaatat 626401 tttgtggata gtgtgtataa agcgcttact ttgtttattt attaggggat gttctgtgga 626461 taaaaagcac ctctaaaaag aggtgcttga cttttttaat cttcttctgt ggatagttct 626521 tcccattcgg acaaaagaga ttccagctcc tgattaagct tctcattgtc tgcatggata 626581 gcttgtactt tttcatgatc ctgatagact tcagggtcac atagcaattc atcattgcgg 626641 ctgatgttct cctcaatggt ttgaacggtg gtttcaattt cttcaatccg acggagtcgt 626701 tggcgctctt tctttttcca ttctttttct tcctcgtagg aacgtttgga gtcagacttc 626761 actgtagctg gcgttttatc agtttcctct tgctgattca ttttctccaa ttcaagctgc 626821 tctgtttttt tctctgtata ataatcgtaa tctcccagat actcctctat atggcttgaa 626881 gaaagctcca atactcttgt ggcgattctg ttaataaaat atctgtcatg tgagacaaat 626941 aacagtgtgc ctggataatc aatcagcgcg ttttcgagaa cttctttgct gtctaaatcc 627001 agatggttcg tcggttcatc aaggatgaga aagttggctt tttgaagcat cagcttagct 627061 agagccaatc ttgctttttc gcctccgctc agtgaatgaa ctggtttcag cacatcatct 627121 ccggagaata agaaatttcc gagacacgtt ctgatttctt tttctgggag cccggggtac 627181 tcgtcccaca gctcatcaag gacacgttta gaggaagtca actcagcctg ttcctggtca 627241 taatagccga cactgacatt tgagccgtaa gaaattgttc cctgatctgg ttttagggtg 627301 tctattaatg ttttcagcaa tgtcgattta cctattccgt tagggccgac aagcgcagcg 627361 ctttctcctc ttgtgagcat gaatgacact tctgttaaaa gcggcggctg gttttcatag 627421 ctgattgtga gatcctgaac acgaaggact tcatttccgc tctgttttgt aatatcaaaa 627481 tgaaagtttg cggatttttc atcgccaagc ggttttgaca tgacatccat tcgctcaagc 627541 tgctttctgc ggctttgcgc ccttttggtg gtagaggctc tcgccagatt tcgatctacg 627601 aagtcctgca gctttgcaat ctcgtcctgc tgcttttcat acattttcag atctttttca 627661 tactgcgcgg ctttttggtc gagataagcg ctgtagttgc cgtgatactt tttgctttct 627721 gctcttgata cctcgtatac ctggtttact actttgtcca aaaagtagcg gtcatgcgaa 627781 acgatgagaa tggcgcctga atagccttgt aaataatgct caagccaggt aagcgtatca 627841 atatccagat ggtttgtcgg ctcatcaaga atgagcaaat caggctgtgt taatagaagc 627901 ttacctaaag ccagtcttgt tttctggcct ccgctgaggc tttgaacctg tgtagaatcg 627961 tcaaaatggc tgaagccgag accatgcagc acagatctaa catccgcttc atattgataa 628021 ccgcctttat ctttgaattc ctgctgaaga cggtcgtagg ttttcatgat gctttctaat 628081 tcacccgggt cagctgccgc cattttttct tccatagccc gcatttcctt ttccattgct 628141 tttaagtggt caaaaacagt cagcagctct tcttttatgg taagcttaga atccaagcca 628201 gtatgctggg cgagatatcc cattgtaata tctttcggtt taataatttc gcccttttca 628261 tacgaaagct ggcctgcgat aattttaagg agcgtggatt ttccggcgcc atttcttcct 628321 acaatggcga tgcgatcacg atttctgact tccagcttta tattgtttaa aatagtatca 628381 gcaccaaatg atttggacag ctgattaact tgtaagatca tcatattatt tcacctctgc 628441 tataataagt taagtgtagc ttatgaacca gaagtcagca aacaatacat tggccatata 628501 agacatagag aagaaaatag tgtatgatct gtttaaggag cgttttaata tgaatggatt 628561 ttctcatttt aatgaacagg gcagagccca gatggtggat attagcgaaa aatcttcgac 628621 tgtccgtact gcggcggctg tttcaagcgt acacatgaag aatgaagtgt acgagaaaat 628681 acaaagtcac gatatcggca aaggagatgt actggctgtc gcacaggtgg caggcattat 628741 ggccgcaaag caaacgtcga atatcattcc gatgtgccat ccgctttcat tgagcggggt 628801 agatatatcg tttgactgga aaataaaaga agcagaagtt atacttcata taaaagcaca 628861 ggtcaaaacg aaagggagta caggtgtgga aatggaagcg ctcacttctg catcggtgtg 628921 cgctcttacc gtttacgata tgtgcaaggc ccttgataag ggaatggtca tcggccctac 628981 tttcttgctg gagaagacag gcgggaaaaa cggtgacttt aaaagagaac tatccgagta 629041 taatttggag gaccaaaaat gaataaggat caatcaaaaa ttccgcaggc gacggcgaaa 629101 cggctgccgc tttactatcg ctttttaaag aatctgcatg cgtcaggaaa acagcgtgta 629161 tcatccgctg aactcagtga tgccgtaaag gttgattctg ccacgattcg gagggatttt 629221 tcctattttg gagctcttgg caaaaaagga tacggatata atgtggatta tttgctgtct 629281 tttttccgga aaacgcttga tcaggatgag atgacagacg tcatcttgat tggtgtcggg 629341 aacttgggaa cggcatttct tcactataat ttcacaaaaa acaataacac aaaaatttct 629401 atggcttttg atataaatga gagtaaaata ggaactgagg taggcggcgt gcccgtctat 629461 aaccttgatg accttgaaca acacgtaaaa gatgaatcag ttgccattct tacagtgcca 629521 gcagttgccg ctcaatccat tacagacaga ttggtcgcat taggaatcaa gggaatcctt 629581 aattttacgc cggcccgttt gaatgtgccg gaacacattc gaattcatca tatagattta 629641 gcagttgagc ttcagtcact ggtttatttt ttgaagcatt attcagtttt agaggaaatc 629701 gaatagaggg aaaggaggag cccaaatatg ccgatcggtc ctggaagcct tgctgttatc 629761 gcaatcgttg ctctgattat cttcggtccc aaaaagctgc ctgaattggg gaaagcagcg 629821 ggagacacac ttcgtgaatt taaaaacgct actaaaggat taacgagtga tgaagaggaa 629881 aaaaagaaag aagatcagta agttaggatg acacgaatga aagtgaatca aatgtcgctg 629941 ctggagcata ttgctgagct tcgaaaacgg ttgctgattg tagcgctggc gtttgtcgtt 630001 ttctttattg ctggattttt tttagcaaag ccgattattg tgtatctgca agaaacagat 630061 gaagcgaagc agcttacgct taacgcgttt aacctgacag acccgcttta tgtgtttatg 630121 caatttgcgt ttatcatcgg catagtcttg acctcgccgg ttattcttta tcagctttgg 630181 gcttttgtga gcccgggcct ctatgagaaa gagcgcaaag taacgctcag ctacattccg 630241 gtctctattt tgctgttttt agcgggctta tctttttcat attatatttt atttcctttt 630301 gttgttgatt ttatgaagcg gatttctcag gacttgaatg tcaatcaggt gatcggaatt 630361 aatgaatatt ttcattttct tctgcagctg acgattccgt ttggactgct gttccaaatg 630421 ccggtcatcc tcatgttttt gacaaggctc ggaattgtga caccgatgtt cttggcgaaa 630481 atcagaaagt atgcgtattt tacgctgctg gtgatcgcag ccctgattac accgcctgag 630541 cttctgtccc atatgatggt cacagtcccg cttttgattt tatatgaaat cagtatcctt 630601 atatcgaagg ccgcttatcg gaaagcacag aaaagcagtg ctgccgatcg ggacgtgtct 630661 tctgggcaat aataaaaaat ccatttctca tgcgagaaat ggattttctt tatttttggt 630721 tctttttgat tttaaatgaa aaggcgaaca tcttaaaaga aatgctgatg ttgtaagcgg 630781 cgaacaccat cagcaggatg gagtaaaatg accacatgct gcctggcgag cttgcggcaa 630841 gataagtaaa gatgcaccct acggcaaagt agatcattcc ccaaactacc gggtttctca 630901 taaaaataat cctccaataa tcaattgcat ttgtgtgctc tgctgttcaa ggtaattacg 630961 aacaggctca agctgcatga tgacgacgaa tgtattcatc attaaatggg cgaaaatcgg 631021 cacccatatc cgttttgttc tcgcatataa aaaggcaaag gtaaagccca ttgctgtata 631081 tagaaggaga tgcttcaaat cagcgtgaac aataccgaag ataaccgagc tgatcagtcc 631141 tgcgaaaaag aaattcgttt tttcgtacag cgcgccgaaa atgatttttc tgaagatgat 631201 ttcttctaat ataggcccga cgatggaaga aacgataatc atgagcggga ctgcctgaat 631261 gacatccaga atcgcttgtg tattttctga ttctcttccg atgccaaaaa cataatattc 631321 aatagagcct gctattcctt gagagaaaag ggcaatgaaa aaaccggcta tcgcccaaag 631381 gatagaaagt ccgattgagt ccttctgtcc gtttcgcagc gtttctttcg gaacggttct 631441 cagaatgagc agaacaacaa cgagacaggc gataaagctg ataacggacc ataatccttg 631501 tgcatgcagc atattttcat ctgtaggctg tcctccggca taaccgaatt taaataacaa 631561 gggaatcgcg attaatgcgg aaaactgcat gatgatatat gtcaaaataa taaaccaata 631621 ctgttttctc aaatggtatg tactcctttg ttaagtgggt ttcgttcatc tacagctatt 631681 gtaacataat cggtacgggg gtgaaaaagc taacggaaaa gggagcggaa aagaatgatg 631741 taagcgtgaa aaatttttta tcttatcact tgaaattgga agggagattc tttattataa 631801 gaattgtgtt agcactcttt agtgctgagt gctaaaatta catattcata ctattgagga 631861 ggttatttca ttgttaaagc cattaggtga tcgcgttgtc attgaactcg tagaatctga 631921 agaaaaaact gccagcggaa ttgtgttgcc ggattctgca aaagaaaaac cgcaagaagg 631981 caaaatcgtg gcagctggtt caggtcgcgt gttagaaagc ggagagcgcg ttgctttaga 632041 agtaaaagag ggcgaccgca ttatcttctc aaaatacgca ggtactgaag tgaaatacga 632101 aggtactgaa tacttaatct tacgtgaaag cgacatttta gctgttatcg gctaattctt 632161 aaataaacaa tacttaaaac atttgaggag gtcttgtaaa catggcaaaa gaaattaagt 632221 ttagtgaaga agctcgccgc gcaatgcttc gcggtgtcga tgcacttgct gatgctgtta 632281 aagtaacttt aggaccaaaa ggacgcaacg tggttctaga gaaaaaattc ggttctccgt 632341 taatcacaaa tgacggtgta acaatcgcta aagaaatcga gctagaagac gcgtttgaaa 632401 acatgggtgc taagcttgtt gctgaagtag ccagcaaaac aaacgacgtt gccggtgacg 632461 gtacaacaac tgcaacagtt cttgcgcaag caatgatccg tgaaggcctt aaaaacgtaa 632521 cagcaggcgc taaccctgta ggcgtgcgta aagggatgga acaagctgta gcggttgcga 632581 tcgaaaactt aaaagaaatt tctaagccaa tcgaaggcaa agagtctatc gctcaggttg 632641 ctgcgatctc tgctgctgat gaggaagtcg gaagccttat cgctgaagca atggagcgcg 632701 taggaaacga cggcgttatc acaatcgaag agtctaaagg cttcacaact gagcttgaag 632761 ttgttgaagg tatgcaattc gaccgcggat atgcgtctcc ttacatggta actgactctg 632821 ataagatgga agcggttctt gacaatcctt acatcttaat cacagacaaa aaaatcacaa 632881 acattcaaga aatccttcct gtgcttgagc aggttgttca gcaaggcaaa ccattgcttc 632941 tgatcgctga ggatgttgaa ggcgaagcac ttgctacact tgttgtgaac aaacttcgcg 633001 gcacattcaa cgcagtggct gttaaagctc ctggtttcgg tgatcgccgt aaagcaatgc 633061 ttgaagacat cgctgtcctt actggcggag aagtcatcac agaagatctt ggccttgacc 633121 tgaaatctac tcaaatcgct caattgggac gcgcttctaa agttgtcgtt actaaagaaa 633181 acacaacaat cgttgaaggc gctggcgaaa cagacaaaat ttctgcccgt gtgactcaaa 633241 tccgcgctca agtggaagaa acaacttctg aattcgacag agaaaaatta caagagcgtc 633301 ttgctaaact tgctggcggc gtagctgtca tcaaagtcgg cgctgcgact gaaactgagc 633361 tgaaagagcg taaacttcgc atcgaagacg ccttgaactc aactcgcgca gctgttgaag 633421 aaggcatcgt atccggtggt ggtacagcgc ttgtaaacgt atataacaaa gtcgctgcag 633481 ttgaagctga aggcgatgct caaacaggta tcaacatcgt gcttcgcgcg cttgaagagc 633541 caatccgtca aatcgcacac aacgctggcc ttgaaggatc tgtcatcgtt gagcgcctca 633601 aaaacgaaga aatcggcgta ggcttcaacg ctgcaactgg cgaatgggta aacatgatcg 633661 aaaaaggtat cgttgaccca acaaaagtta cacgctcagc tcttcaaaac gctgcgtctg 633721 tagctgcaat gttcttaaca acagaagctg ttgtcgctga caagccagaa gaaaacggtg 633781 gcggcgcagg aatgcctgat atgggcggca tgggcggtat gggtggaatg atgtaataaa 633841 gggatattaa cccttataca tcaatgtttt aaccgtctta aaaaactaga caaagcgtga 633901 ataaaaaaag agaaggtctt tcatcagttt actaaactgt tgggagacct tttctccata 633961 ttagcggtca tatgagcata aatgtccatc gtcgtattta tgtccgaatg accaaattgt 634021 tgctggattt ctttaatgcc tactcctgcc tcaattagta aggaggtatg ggtatgccta 634081 aaagagtggg gggtgacatt ctttttatcc cagctttttt gagcagccgt ttaagtctag 634141 tctcaataac ctttcttaat tgcggatgac catcctcccg ctcaaaaata aatgatgagt 634201 cttgataaat caatctattt ttaagcttaa tttcattttg ataaatttta ttttttttta 634261 gtagattgac atcgtttcat caattcgaac gatatcaaca gatcctgttg ttttaggtgt 634321 tagcaattgg tatttttcaa tttgattgtt aggggtgtat agggtctttg tgacctggct 634381 tatcattgaa atctgtccat tttaaagcaa gaagttcacc aattcttagg tcggtctagg 634441 caagtacggt aaagaccaaa tggtccattt ctagcccgtc agattgagcg agctttagaa 634501 aatgtgtcag cacctctttt tccaatgctt tgttgcttct tgggtaattg aaaatcccca 634561 gttgggttca ttttaataat cccttgagtt ttagcttttc ggaaaatcat acggccgcag 634621 gcatgaatac ctcccaaaca attgtgactg tattgctcgt tcagttctaa cgtgcggtct 634681 tcatacattt ttttgtgttt tgctaatcgg gtattgaccc aatactgcga taaaatgcat 634741 cattttcttt tcactggccc gtacactgct tatttttacc ccactccggt tgtaaatctt 634801 aagccaacct tttgcaaatg ttttgaaggg catatctgac tccttaataa aagtcccgtt 634861 gtcgttttgg agttctacgt gacgggctgc tactggggct tctttctttg ttttaaatct 634921 tcctttggat atttctagac gttttttggt taaagggtca atgcctagta gatatgataa 634981 ctccacgtct taccgcattg cttgagtttt gccatttatt tgtccctaac taattttttt 635041 tcatcaaatt ggtctttaag tgagtttaat aatttttgtt tctctcgact ggtcaataat 635101 tgcccttcat atttcaaaag attggataaa tttgagatgg aatcaatcct gatggattct 635161 aaaagctttg taaatttcta attttatcct ggcctactgt gcaacagacc ttcttaatcg 635221 agcctaattt tccatctatt tgattgggga acaaatggct ttttaacaag aaagaagtcc 635281 aagaatacat tgattggtgg tcaattgagg ttaaaaggaa aaagagggcc tgatatatct 635341 ttcactttcg cctaactagc aaaatttaat aaaacgataa gcgatgtgag gtgaaaatta 635401 tgctaagtga taataatttt gtttccgaaa cactggagaa tgtacagtat ctattgccag 635461 gtgcaaaagt aatcaaattg aggggataca gcagggccca caaagtatac accattgcaa 635521 aatccccggt agaaaagtgg aaggtcgccg caggtttatc cggatcagag atagcaattc 635581 tgattagaaa aggtcattgg attggtgcaa gcattccagc tggcggaatt gtcatcgata 635641 ttgatgattc aaaacaggga gagctagtga aaggtttact agatgcgcaa aactttcatt 635701 gtcattgtat taggacccta atgggtggca gtttattttt aaggataacc aacatgggga 635761 aaagaaaatt aaacaaataa ccaaattttt tactcaaata ggtatcatag tcgatgctgg 635821 gatcgctggg gcaggctata ttgttttccc aacaagtaac actgaggacg atatatagta 635881 actaagagtc ctaatgagtt agatgaaata cctaattatc tgaggcctgt acggaattct 635941 gttaatgtaa aggacaacaa cactggtgaa aaatatgtat tccctgtacc aatcgacaga 636001 gttggtagca gaaatgatac tttaaatttg ctacacattt gaaagcctgg aaggtggaac 636061 catacgaaat tagcaaggcc atggaattga tttataaata ccttctgctg gataaaaaag 636121 atttctcttt ggaggaattt tataaactca ccatatatgc tatcaaatgg aaactggaac 636181 aagctcagtt tccattgtat ttagaatcca caaaaaaatc gcatcaaaat gttattcccc 636241 agccgtttaa gataaaagga aatgtcttat ataaaacggt aatcaagaat agcggggact 636301 ttgaagaata gctcatcatg gcgtgtagga gtgattcacc cttttaagaa actgtctaat 636361 atcgaaagaa acagtgttca ttatgaacta gcctcaaacg ataacggacg cgaaaaaaag 636421 gatatagttc ctgctagtgt tatatcacca agcgggagtt gcttttcatt ggcggataat 636481 gggctagttg agaaggaagg gcaaaaaatg aagctgacag agagacaacg acgcttttgt 636541 gatttcttta cagaaactag aaatacaaca gaggctacgc gtctagccgg aaacaaaggg 636601 aaaaatctca acagagtagc ttctcaaaac ttgtcaaaac tagacattca aactatatag 636661 agcaaagaaa taatcaacta gaagcggagc gcatagcaaa cattattgag gtaaaaatgt 636721 tttggacaat tattatacgc gatggaatag ttcggttaaa gagcgactaa aggcgtctga 636781 gtatattact aaaacaaatg cggccttcaa ggaatagatt gaacatactg gtgaaattaa 636841 aacagggaat gaggaagaag ctaaattcga atgagagtga tctaaggctt ctagaattgt 636901 atatggaggt gtggtaacgt gagcaagctt atatagaagg attaagtgat caagtttagt 636961 gtaatactag gaatgataag gtgttcatta acgcacatta caactaaaaa taccgtaaat 637021 gccctcaaga ggatgatata tccaaagcaa aaaccttcat tctttcatga atttaaagta 637081 ttatataagc tactgaaaaa gttttgtata aaaggtataa tgataaagaa cattcgttct 637141 tgtatggggt actttctctg agaatgaaaa taatgtctta gggtgatata atgacaaatt 637201 ttattttaaa tgaaaataaa cagttatcat tggcaattga agatgagaac atagaaaatt 637261 tttatataga tggtacagat ttagtccgaa agataatccg tagatcaggt tcaggagtta 637321 catcacgggt tccggtcctt agcacccaag atttagaaaa caagaacctt catgaattat 637381 acgatgaatc ttggctccgt atgaaaaaca gacccaatac tgagctcact actgagagta 637441 taaatattgc ggatttattt agtggatgtg gaggtctatc cttaggggtt tgggaggcat 637501 gccgtgccct ggggataaat ccaagatttt cgtttgcttg tgatcttaac gaagctgcct 637561 tatctgtgta cgaaaaaaac ttttctcccg attttagctt gaatgaatcc atcgaaaaac 637621 atattaatgg cgagttaggt gctccattaa ctgttgaaga gcaaagaata aaagataagg 637681 tgaaaaaaat agatttcatt ctagcaggtc ctccttgcca agggcattct gatcttaata 637741 accatactag acgaaaagac cctagaaacg ctttactaat gagagtaagt agagttatag 637801 agttgttcca accttcttca gtattagtgg agaatgtacc aggaattatt catgataaat 637861 ctggttcttt taaagaattt aagaatcatt taaagacaca aggttattac ttcgatgaaa 637921 tcgtactaaa tgctgaaaaa ctaggtgttt cacaagcacg tcgtagatat tttatttttg 637981 cttcaaaaac tcctgtatct tccttaaatc aaataaatga attttattca accaatagta 638041 ggccaattag ttgggcaata tcagatttag tagaaaatgt aggtgatgat atattcaaca 638101 ctgcttccga gcattcattg gaaaacaaaa ggagaataga atatcttttt gaaaataact 638161 tgtttgaatt acctaattca gaaagaccgg attgtcatcg gctaaaacca cattcataca 638221 aatctgtgta tggcagaatg tattgggata gacctgctcc cactataacc agagggtttg 638281 gatcaacagg tcaagggaga tttgttcatt ctttgttaaa gagaacgata actccccatg 638341 aagcagctag gattcagttc ttcccggact tttttaactt tggtgacctt cggaggagac 638401 agtatcaaga cgttatcggt aatgctgtgc cttccaaact atcctattta ttagcattac 638461 atcaattaag ataaaaagat ttgaggttga tatctttgaa agttgttagt ttattctccg 638521 gcataggcgg aatagagctt ggccttcatc agtcaggaca tacaacagaa atattttgtg 638581 aggttgatcc tttggcaaaa gctgttttat caaaaaactt ccctggcgtt aagatagaag 638641 atgatattaa tgaaattaga gagttaccaa gctgtgattt agttgcggca gggtttccat 638701 gccaagattt aagtcaagct ggaggtaaag aagggattga cggatcacgc tccggtttag 638761 ttaagaaact atttgaactt atagaaaaga aagaacatgc aaatcgccct ccatggatac 638821 taattgaaaa tgtcccatat atgttaaggt taaaccgtgg taaagctatg tcatatttaa 638881 catctgtcct ttctgaatta ggttatactt gggcatatcg aactgttgat gctcgttgtt 638941 ttggtttacc gcaacgaaga catagagtta ttttgttagc ctctttattt gaagatccaa 639001 aagatgtgat tttttcacag gatcattcag aaccagattt agatggaaag ccttctgttg 639061 tggatcattc caactattat ggtttttatt ggacggaagg gttaagaggt gtcggctggg 639121 cacgtgaagc agttccacct ataaaatgcg gatcgtctgt aggtatagcc tctccacctg 639181 cagtttggtc tccttacgag gatatagtag ggaccattaa tataagggat gctgagcgcc 639241 tacaaggatt cccggaagat tggacaaata tcactactga aacaggtaag gatataaaag 639301 aaggtgccag atggagattg gtgggaaatg ctgtttcggt aagggtttct aaatggattg 639361 gtgaaaactt aagtcagcca aaagggtcga tatcagattt tgaaggtgaa ttagtgacca 639421 agacttggcc aagtgcagca tgggggtacg gagataaaaa gtataaagtt cccgtatcaa 639481 aatgggttgc aaacacagaa caaatagcta tttcagagtt tttaaatcat ccattaaaac 639541 ctttatctgc tagggcatta aacggttttt taggtagagc agccaggtgt acaaatgtaa 639601 attattcgga tgaatttatt aactcgttag aacgttgtaa ggataggcaa cttcaaaagg 639661 tttaactttt cacattaaag agagcatact aaaaagtatc ggagctggat aaaaccagct 639721 ccgtttttta tctttaattt tttttgcatt attccatctt ttattcgacc agttccataa 639781 actccttttc aattctttgg gggtttcggg tctcggcaag actttcatct accctgaagt 639841 agaatttgat ttttggttct gttcctgaaa gtcgcaggca catccaggga tccgacttca 639901 agaaaacatt taagaacatt tgactgtgga aggcccatga gttcctcagg gccttccaca 639961 gtctctcgat tccggtcaag taatcctcaa cagtggtaac cttgacggaa ccaaagctgg 640021 ccaaattcag aacggaaggc agcgagggtc tgctgaatca gttctgcccc ttcttttccc 640081 tttagtgtta atgagcgcag gccttcctga aagtagccat attcttcaat actaaggaga 640141 gcttcgtata gtgaaatcct tttttcttat agtaagcaca tacctcaact gcaaggacat 640201 ccgtctgaac agcatccttg tctcggacaa agtcgccaat cagatagcca tagctctctt 640261 cgtacccaaa gaggaaatta tgttctcctg tcttgtagta gccattaatc tttctggcaa 640321 tgaacttaaa tcccgttaat acaccgattg tttcgactct gaaagaggtt gcaacttccc 640381 tcccaagctc cgaggtaaca atcgttttaa gaacgatccc attagatgga agtgttcctt 640441 tcttttttat ttgggttaag atatagtgga gcagaagtgg ctcggtttga tttccggtta 640501 aaaccgtata ctcaccattt tcatttttaa cagcaattcc aagcctgtct gcatcgggat 640561 ctgttgcaat taaatatcgg cgtcaatttg ctgccttccc tgatggccag ctcaaacgcg 640621 gcatgttctt cagcatttgg actggtgata gtggaaaaca gagggcaggc tgctcctgtt 640681 cttttcccac cgctacatgc ttgtagttca ttgccgccaa ggccattgca gtagatttgc 640741 tgtaccatga agcggcgtaa atacaacctt gatgtctgtt tcatcttaaa tatttgagtt 640801 ttctgaaata gttcaaggta tgccttgtcc acctctgcgc tatattttga tcaggccctt 640861 tgctaggagg aagctggccg ccatctggcc cataaacttt atatccattg tattcaggcg 640921 ggttatggct cgcagtcaca acaataccgg caaaaccatg aaggtgacgt actgcaaact 640981 taacacggtt gtaggcctta atgactcgaa aacgtatgcg ctggatgcca gtgtcctggc 641041 ggcttccatt ataaaagccg ccaacccagc agaaactttc cttaacgtat agatgtcatc 641101 cggtttgttc cagctccaat ttccccgcgc atgcctcctg ttccatatcc caaattcctt 641161 ataaaaagca tcttccaggt ctttctcatt ccttcctgat ttacccaacc ccgattttag 641221 ctcggtgcaa gttgactaaa ctgtagccat ttttctgttt tgtttttcca gcctatgatt 641281 gacctacaat aaaataacat tattgttcat tataatatag tctagaggtt ttcgaacgac 641341 gactttctga cataaatcga gtgctcttgt ctgattatgt ctagttatag ttggtttttt 641401 ttattttgtc tctaaatttg atgagatcat ggtggcgagg aatttctttt tcgacagccc 641461 caatcagtac caattcgata tttgaattgg tctctcaaac aattccatcc tctttattta 641521 ttatgataca attatattaa ttagaaaata catacatatt agcttgtgtg attttatggg 641581 ggtaaaatca atgactttta taaaaagatt agaggacgct tatgaaactc tattagggaa 641641 ttaccctgcc ggagtatcta gtaccagtac tagtaagtat aacgaaatac gaaagattgt 641701 ttcagaagcc ttcttgatcg gtgaaaatga agtgtatgta acgggaacat caagaaggat 641761 tagcaatttg gacactcggt ttgctcaagg aaatcaacgg aataaacata cccggatggc 641821 agttgctttt atttctatac cttctgtgga cgattcggaa ttagatgaac taattataag 641881 aacgagaaat agtgcaatta caacctcatc taaattctgt aacggggaag aaaggggcac 641941 gatttttgac ggaatattac tttttttagt atttgagggt gaaaccaaag tgtatccgct 642001 agcattctta gttttcgaga acgattttga attaaaggaa aaggctgagg aattgattcc 642061 aggaattgaa ctcaaagaat acccgcgagc taatcaatcc ccagcccagg aaaataacaa 642121 aagcgctaaa aatgaagatg aggaaagtgc aaagagctat gtagtcttcc ttgatattga 642181 ggaagatggt tctattgtgg aatttgtaga agataaagac aaaacctata gaattggtga 642241 tatgatttgg acggcttcac atactaatgg ttcatcagct atcacacgca gactggaagt 642301 aattgaagtc gttgaaaatc ttgtggtgtg taagataaaa cataaatata atgaacctgt 642361 tgataagaat tcactgctta agtttgtaaa tattgaacaa gatttgattt catttctaga 642421 cttacatcca aatgtccaaa atggaagtga gggatttgta tctggggaca ttgttgatga 642481 gaacgctact acatcatcgg atgacttacc ggaagacttt gaaaataact aagcgataaa 642541 ctttaaatag gggaaatgaa ctgatggaaa tatccaaaca aacttcagat ttattattga 642601 gcctagaaaa gaaaaaaggc actttaccaa aattcagcgt tttacgcagt attcctagga 642661 ataggattat ttatggtgca ccaggaacag ggaagagtaa ttatctagaa agggaagtgg 642721 gaaagatctt tggtgataat ccatatgtat tcacccgagt tacttttttc cctggttata 642781 catatggaca atttataggt gcttataaac cggttcctat atataaaaaa ttaagcggtg 642841 aggaagagat atttagttca aactttaggg ataagatgga aaactttgag ccaatgattg 642901 attatcaatt tgttcctggc ccatttatcg atgtattaat taaagctctg aaaaatagat 642961 acactaattt tatattaatt atcgaagaaa ttaatcgtgc caatgcagca agtgtttttg 643021 gtgatatttt tcaattatta gacagaaata aaaacggtga aagtgattat cctgttacat 643081 tcgggccgga cattatgaat tatttagcga gaaacggaat taaagatgaa atgattaagc 643141 taccatccaa tttctttatt tgggcaacta tgaataatgc ggatcagggt gttttaccgc 643201 tcgataccgc ttttaagaga aggtggtcat ttgaatattt agagttggaa aagtatagaa 643261 aggcagtgga ctcttggaag ctgagcctca gatataaagg tcataataaa gtaattatgt 643321 ggaatgattt ccgagacatt attaataagc gtcttaaagg aaaagtacca gaggataagc 643381 tgcttggacc ttttttcctg aaagaaagtg aactgtggaa tcagaatgta tttaaaaata 643441 aactgcttta ttatttgaag gaagatgttt tcaagcataa tccaacgatt gattttttaa 643501 atgctagtac tttctctgag ctaattgaaa aatatgatgg ctcggataac atttttactt 643561 ttgacataga tgattcgtct tttgtgagtg attaactatg gataagtcaa gtaagttctt 643621 ctttgaagat caaaaataca ataaagaaag gattgtacgt gtactcggtg gtaatttagc 643681 tttactcaaa agtaaaggta tattatatga agattctagt ggggatttaa tatttaacta 643741 tgtaggtgtt atatctaatg ggcgcaatgt aatattcatt ttgcctaaat actgtaacag 643801 gcacttagat gaacattcaa agcggacttt gtttaataag ttgctgaaga tttttaaaaa 643861 atattcaggt ttaaataaaa gccgggaatc tgattatttc gtatcggagc tagatagtga 643921 tgaagtctcc gactttatga tagcagatta tttgcttaat gatttctcat tgaatgggta 643981 ttatcaaaaa aaatttactg aatatgaaat tgatggagaa ggaattatag attggagtaa 644041 gacagttaat gaaattaccc cagtattctc aaagggagtt ccatattatt tcagtactta 644101 taatgaagtg gtacaaaaag acgagtatca cttgatagtt aaaattcata aatgggcttt 644161 aagtaaatat tttaatgatt tcggagtcat tttaggtttt acgggactag aatttgataa 644221 atcctgtgat ggtatgaaaa ttttggacta cgctgatttt tttggctcag taataaataa 644281 agaaatcgtg aacacatatg ttgatcgtga cgttaaattg ttaaaggcat tgaaaaccgc 644341 aattgatagg gaagagaatc agttttctaa acgacccact ctttctctgt atggaacaaa 644401 atactttcac agagtatggg aggaagtatg taagaccgta ttttcccatg ttaatgaata 644461 cgtaaaaaag atatcaaggc caaattggat taactttacg gatatagagg ttaataaaga 644521 gaaaaaaaca ctagaacccg atattattaa ggctttcgaa taccgttcaa aagaatactt 644581 tttaatatta gatgctaaat attataatat aaattttgac ggaaaaaagc tggaggggaa 644641 tcctggggtt gaagatataa ctaagcagct gttatatgat aaggcacttg aaaaactgtc 644701 cagaggtaaa acaaaacata atgcttttct gtttccttcc tctaattcaa ccaatacctt 644761 taaagtattt ggttctgttg attttgattt tcttgatata gccgctgtaa ctcttgttta 644821 tatttctgct gaacaagttt ataacttata tcttgaaaat aaaacatttt ccactgatga 644881 cttatttaaa tttgtaagtg aaattaataa gtcaaaaaaa cgacatagcg ttataacttc 644941 aacattgtat ggtaatatgt ttttgtttac aaaaagatta agtgataaaa attagttcta 645001 gaaggttaaa agccgataac ataatacttg tcctcggttt tgtcctccta tagttttaaa 645061 aatatttatc agcattaaat gttaagtcta aaaaacagta ttttgagctg gtttttttaa 645121 tactattttc aactgttatt agtcggaatg aatgggttgc atgatgtaaa accgacaaaa 645181 aactcttgat aaacaggggt ttgtcggcaa cggactttta tttttgatgc ccttttggcc 645241 atttgcaaat tttcaaggct tctcatgagt tcaccgaact tgtgagaagc ttcttttttg 645301 atgtataaat aaacatgtgt agtgtgtaca agcttacatg gcatttcatt tatggaccgc 645361 ttctctctct attgcagaca ggatacccta ttggtatact ctcatacgac acaaaaaaga 645421 cccagttatc taaataagta gtgccaccca ctcttagact gtttccccta gaaaagcact 645481 gtcaaagagg aatcctgtta aatcttgtgc ttctttgctt ttttagctaa aagacgatgt 645541 tttccttgca ataaggaact cgtcttttat gttaaatata aagagcgaca gaataatgac 645601 atctgatccc caaaaattca ctgtcgatgg agttagattc ttccaacagt accttaataa 645661 aatccgtccc gacgctatgg agatagacaa cctaattatc aactctgata ttatcaagga 645721 ggacttaata gtgcatgtct caaaaatgat agatcgtttg gctttatatg atttacacag 645781 aaaaagaagc atagataaac atttttctgc tgcttttaca gtcgatatca atgatagaga 645841 ggaattttac agtgcaaata tagctgatgt ttcaattgat ttgaatgaat ctagtggtgt 645901 ttaattgaat ctcatattct tcagaagaac cattcaatac ttcttgaaca atatttaaag 645961 tattcatcag cttcctctac tgaaacaata tcttcaatga aatcggaaaa gtattctagt 646021 tctgttcttg ttggaagaac tattcttaag tatcctaaag ggtctctttt aaatgaatat 646081 accatgataa atcagtcttt cctttctgtt tattcttagt taatattgat cgtacaattg 646141 agtcgacaag acaggctatt gtagatttac gggcgttcat tcactggata aaagcaaata 646201 aaaaagggcc tgttatcata gtcggagtaa gccttggggg atgggttact aatctaattg 646261 ctaccctgga atcgaaaatt gatgtagtgg tatctatctt ttatgccaat cgcctttctt 646321 attcgatatg gaacacgatc ccaggtaaat acataagaga agaattagaa caaaatggtg 646381 tgacctataa tgagttaata aaatattggg atatcacaga tcctagtcaa gccttgccga 646441 aagttaataa agataacgta ctgctgattt ctgctaaaca tgatcaatat attgacttga 646501 aagatgcaga ttatttatgg gaaagttggg ggagacctac aagatatgtc tacaattgtg 646561 gtcattccgg tattgttctt tgtcgcaaaa agctggcaaa tgatacgctt tcctttatac 646621 gagaaaaact ggtttgatac atttgtagac tttaataaga aacgaaaggc caactgcgac 646681 ttcagttggc ctttcctatt tataataaag aaattgagtg agattgctga cagaactacg 646741 tactactcgt tttctttagt tgcccttgct aatcgttcaa cctctccccg aatcccaatc 646801 gcaggctccc acgaatcaat caaacgaatc gccttctgat tagattccac cgctttcgtt 646861 ttctctcctt tacgatacaa cagctgcgcc attccgtagt gatagtagat cagttcaact 646921 tgattggcgt tatgtttgtc atagagcatt tgctcaaagg cttcttccgc tttttcaaac 646981 tgatcacatt tcacgtaagc gacacccaga ttgaaatagg cttctatcgt tttttcgccg 647041 ccgtatgtgg agctgatttc atttgccgct tcgtataatt gaatggcttc tacatgataa 647101 cctctcgcaa agcttaagtc accgcgaacc aatagaactc tgtgttgaat ggtaggggaa 647161 atcggttgat tttcgatttc gtttaaaatt gtctctgctt tttcctgttg cccgtctttt 647221 aaaaacagcc ttgctttgag tgcatgtccc caaaccttta gatcataggc atcgtgagcg 647281 tctgattgtt caagaatctt cagcccggct tctatttgct gaagcgctcc gtctaaatca 647341 ttgacttcca tcaatgccca gcctgaggtg tcgattcgga agtacgcttc tcgtgtgtgt 647401 tggcctaagt gatgggcggc gtcggccgct ttgcgtccgt attcgattcg caggggcagg 647461 ttgattctgc ttagaaaatg gctaatgcgg gtgatgagtt cgattaggat ttctttttgt 647521 tcagtttcac ttgcccattg gatgaccttt aagatgtttg gccattcttg tttcatttga 647581 tctaagttcc gtcccagcag gtagctccaa tagatagagt tgggctgttc ccgctttaaa 647641 tgggtttcgg cataatcaat ataatagtgc gcccagcgat tgcgggcttc tttttcatat 647701 tcgtgctgtt cggacaagtg ctgttctccg taagcgacaa cggtttggtg cgctaagtat 647761 tgtgtcctgc cttggcttcg ttccggctga atcagcgcat atgaccgcat ttgttccata 647821 gcgtaatgaa aacggcgggc gtctaatccg gctgctgccg ccaggctttt ttcatcaggc 647881 ggcttgctga aaaagcaaag cgtctgccag agctttcgcg tatcttcatt gcatctatcc 647941 caggtgcggc caaagaggaa ttcaaacaat tccagcagtg agtagcctgc ttttccaagc 648001 tcatgaatca gctgctgagc ggggatgtca tcgtctgaca tataggcaat gctgagtgcc 648061 atggctttcg ggtttccggc agtcgctgaa atgaattcgt ttttcaggtc agatgataga 648121 tgtaacagct gctccagctt ttcccgttta cgtgggaggt tgcatgtttg taagcagtga 648181 tgcacttctt gttgaaaaaa ttcgtgggca tctgtttggt caagaccgct tagctgaatg 648241 gctgtcattt ctccgaagct ttcccgataa gtttgcttta cgttttcccg cgctgtaagg 648301 agaactttta cgccttgcgg aaggctggtg ataaattcat gaatgtcacg ttctgcagta 648361 tcaatgctgt caacgatcag caggatcggt ttttctctag tgtaattggc taacgcattg 648421 cggacgacaa accgttttac attgattgat ttatcgattt gttctttgcg tccgagctga 648481 taggcgatcg tatttaaaaa atcgctaaag cttaatcctt tccaatcagc gctgacccag 648541 atgatgctgt tgaatgccgg ccaaactgaa gtatcgtcga cacaggaata ggcggcttca 648601 agagcaattg tggtttttcc catgccggcc cagccggtga ttaaacagac tggtgatgga 648661 gaaagcatcc attgccgtat cgcttccata tcaaagctgc gtccgataaa gcgtccggac 648721 cagcgtgagg gtaaattatg cgtgatgggc tgttctgtaa gcgcattcgt ttcttggccg 648781 ggtctgtcat gaaacagccg ttttactaca ttttcaattt cgccttcact cggagccccg 648841 aataatccgt cttttcgcag tattttcgct tttttcaaac aggatgctgc ccatacaggc 648901 aatgcgggtt tgatgactgg gatagtggtg gcttccagca agtcggtcaa ccactcgata 648961 tccaagtcgg tcttttcgag aatgatccag atcattccga acagttttcc gtcgtcgatt 649021 cttccgggaa tgtagtttgc ccccatctgt ccgatccagc ttttgatcgt gtttggggag 649081 actcccagct ggagtgcgat tttatctatg taagactgtc ctgttttttc attctttttc 649141 cttctgactt tataatcagg atgaagtttt agcgttttga cgccaggtgc cagcatttgt 649201 gcaaattgtt ttcggttttc aagttcagcc ataagcctgc acctcctatt agtactattt 649261 tatcaatcca gcgttttttg tatatgaaaa aataaaagta cagtgccgct gtccttttat 649321 acagcaggaa aggctgttga acgtgttaaa aagcagataa aatgggggca gtaacagaga 649381 aaacaaaaat gtatgcactt acattttatt ttctaaagaa aggaacttgc caaatgactc 649441 acacagtacc tcaaaacatg aaagcggctg ttatgcacaa cacaagagag atcaaaattg 649501 aaacattgcc tgtgcctgat atcaatcatg atgaagtgtt gattaaggtg atggctgtcg 649561 gaatttgcgg atctgatctg cattactata caaatggccg aataggcaac tatgttgtgg 649621 aaaaaccatt tatccttggg catgaatgtg cgggtgaaat tgccgctgtc ggatcatctg 649681 tcgatcaatt caaggtggga gaccgcgtcg ctgtagagcc gggtgttacg tgcggacgct 649741 gtgaggcgtg caaagaagga cgctataatc tttgcccgga tgtacagttt ttggctacac 649801 cgccggtaga cggtgcgttt gtccaatata ttaaaatgcg tcaggacttt gtttttttaa 649861 tcccagactc actttcttat gaagaagctg ctttgatcga gccgttttct gtcggtatcc 649921 atgcggcggc cagaacgaag ctacagcccg gatcaacgat tgcgattatg gggatgggcc 649981 ctgttgggtt aatggctgtt gccgcagcta aagcatttgg ggcaggcaca atcattgtca 650041 ccgacttaga gccgctgcgg ttagaagctg cgaaaaaaat gggagcgact cacattatta 650101 atatacgtga acaggatgca cttgaagaga ttaaaacgat cacgaatgat agaggcgttg 650161 atgttgcttg ggaaacagca gggaatccag cggcattgca atccgcactg gcttctgtgc 650221 gccggggcgg aaaattggcg attgtcggtt tgccttcaca gaacgagatt ccgctcaacg 650281 tgccgtttat tgcggataat gagattgata tttacgggat cttccgttat gccaatacgt 650341 atccaaaggg aatcgaattt cttgcttcag gcattgtgga cacgaagcat ctagtaacgg 650401 accaatattc gctggagcag acgcaagatg cgatggagcg ggcgcttcaa tttaagaatg 650461 aatgtttaaa agtgatggtg tatccaaatc gctgagtgaa cagggaggat cttcgtattc 650521 tccctcttgt ttactggaaa tgaaaacgga ttcttggggt gggaaatgat gattggaaca 650581 gaaaaagtaa cggcattgaa ggcgaagcat cagtcaaaat ccagcaccgg cctgtcctgg 650641 tttgaacgaa tcggttatgg attcggcgat atgtcgtata atattatctt tcagtttgta 650701 aacgcatact tattatttta ttatacagac gtcggcggca ttcagcctgc ggtaatcgca 650761 actttgtttc ttgttgtgcg tgtgctggat gctatttttg acccgatcat gggattgatt 650821 ttagataaaa cgaatacaag gtggggaaaa gcaaggccat atttgctgtg ggtggcattt 650881 ccttttgcgc tattcacatt cttatgtttc acgacgcctc atttcggtga gaccggaaat 650941 atggtatatg cgtatgtcac ttatattctg cttgggatgt cctttagtat gcaaacgatc 651001 ccggtgaaca gcttaacggg gcggatgacg aattcggtgg aggaacgaac ggttctgacc 651061 acaacccgga tgattttggt gtatatcggc attcttttat ccatttcctg tgcgacaccg 651121 cttgcaactg ctatcggagg agaggatcag gcgtttggat ttcagatgac ggcgctcatc 651181 tatgcggctg tcagcatcgt tttgaatcta tttagtttct ttactgtacg ggagcggatt 651241 cagcctaaaa agagaaaaaa acaagggatc aaaaagacgt tatccgtttt attcaaaaac 651301 aaacccttgc tcatgttaat ttcatcattt ttggcttttg cgatcgggtt taatattaag 651361 ctcagcacga tggtgtatta ttttacgtat aacgtaaacc ataaagagtt cgtgtttatg 651421 ggcaccgttt tatttttcgg ggcagcgctg atcagcaatt tgtttattcc tttcttttct 651481 gagaagtggg gcagaaaaca agtcatgatt atcacggcag ctctatcgct tatttcttat 651541 gccggcctgc attttacgcc gtattcttca attccactca ttttcatttg gcttttcgct 651601 tcgggatttt tcacaacgcc tttaaatacg cttgcttggg gaatggttgc ggattgcgtc 651661 gattatgcgg aatggaaaac cggaattcgc gcggatggtg ttgtgatttc gagcatgagc 651721 tttattaata agctgggtgt tgcgttagcc gggtcatttt cggccattta tttaggaatc 651781 gccgggtatg tggcgaatac agaccagaca gttgcgtcgt tgaatgcgat taaaaatatg 651841 aatgctttga ttccgggatt tttcattttg ctttctatta ttcttatcgc cttctatcct 651901 ttaacggaaa aaagatataa acacatcatc tctgagctgg agcaaaggtc tgcgagataa 651961 atagatgtaa aatttttaat attcaatgtt gtatttatgg caaaaagtaa tatactgaga 652021 ctgtaatcta gactttataa atgagtgtga taatatgcgt agtcattctg tagtttgtat 652081 tggggaattg ttgattgatt tcttttgtac cgatgttgac gttgatttaa tggaagggcg 652141 ccaattcctg aaaagtgccg gcggggcacc ggcgaatgtg tcggcagcga ttgccaagct 652201 gggcggagac gccgctttca gcggaaaagt aggaaaggat ccgtttgggt attttctgaa 652261 gcgaacattg gacgctgtac atgtcgatac ctctatgctg gtgatggatg agaaagcgcc 652321 tacaacgctt gcttttgttt cattaaaaca aaatggagag cgtgactttg tttttaatag 652381 aggcgcggac gctttgttta cgctggagga cattgaccag gaaaaactaa acgaagcgaa 652441 aatccttcat ttcggctctg cgacggcact gttatcggat ccgttttgct cagcctattt 652501 acggttgatg tcgattgcga aagacaatgg acagtttatt tcgtttgacc ctaactaccg 652561 tgaagattta tggaggggaa gagtctcaga gtttgtaagt gttgcgaaaa aagcgatcgc 652621 tgtaagtgat tttgtgaaag tcagtgacga ggaacttgag attatcagcg gtgtgaagga 652681 tcatgaaaag ggagttgcga tccttcatga gatcggagcc aacattgtcg ctgtgacact 652741 tgggaaaagc ggaacgcttc tttccaatgg aaaagaccgt gaaatcattc caagcattcc 652801 ggtgacatca attgactcaa caggggcggg agatgctttt gtcggtgcgg ctttatatca 652861 attggcaaac acggatcaga ttcaatctgt agatgctgat tttgtgaaac tgcgtgagat 652921 tgtggcgttt gccaataagg tcggagctct tgtgtgcact aaaattggag cgattgatgc 652981 actgccgagt ttggatgaga ttggagtttc tttgtaaatc attgaagatg tttcttgaaa 653041 gtctttggac ttttgggggc atcttttttt attgcttaca tttttgttca ggtaaaaagt 653101 tgtatatttt ttgtttgaaa tgtcattttt tattaaaaaa gtgaaacttt taacgataat 653161 aaatagtata tgtaacaagg gttaccgaat tagctttagg aggaacgata taatgagtat 653221 aattggaaga tttaaagata ttatgtctgc gaatatcaat gctttattgg acaaggctga 653281 aaatccggag aaaatggtag atcaatattt aagaaatatg aatagcgatt tggctaaggt 653341 taaggcagaa acagcagctg ttatggctga ggagcagaga gcaaaaagag aatatcacga 653401 atgccaggcg gatatggaaa agatggaaag ctatgcaatg aaggcgctgc aagccgggaa 653461 tgagagcgat gcgagaaaat ttcttgaaag aaaaacatct ttggagtcaa agctttctga 653521 gctgcaggcg gcgaatcaaa ttgctgcaac caatgccgca cagatgagaa agatgcatga 653581 caaattggta tctgacattg gagagctgga agcacgcaaa aatatgatca aggcgaagtg 653641 ggcagtagcg aaaacgcaag aaagaatgaa caaactgggc gcttctgttt caagtacaag 653701 ccaatcaatg tctgcattcg gccgaatgga ggacaaagta aataaggcac ttgatcaggc 653761 caatgcaatg gctgaactga acagcgctcc gcaggatgat atggctgatc tgtctgcaaa 653821 gtatgacact ggcggttcaa gccaggttga tgatgaactt gcggcgttaa aagcgaaaat 653881 gatgctcgat aagtaataca taggaggccg cagctttcgg ctgcggcgtc attttatcat 653941 aaaatgtgag agggaacggt aatgataata tcttataagt gtccgaactg cggcagtgat 654001 atggcatttg acagtgaaac cggctcgtta tcctgcagca gctgcggaag acaggacaat 654061 attgaaagcc ttccgaaaga aaacattgcg gcacggtttt ctgatgatga agcaaaagaa 654121 tatcaatgta aaaactgcgg tgccgttttg atcacggaag ctgaaacgac agcaacgacg 654181 tgcagcttct gcggaggtgc tgcaatactt gccgatcgtt tatcaggaca tttggcgccg 654241 gcgaaggtca ttccatttac aatcagcaag caagaagcgg agcaggcatt tcgaaagtgg 654301 tgcaaaaaag gccttctgac accaagaggt ttcatgtctg ctgatcgtat caaaagcatc 654361 accggcatgt atattccatt ttggatgttt gatttaaata gtgaagtaca ggtgagagca 654421 aactgtacca gagtccatca atatgaagaa ggggattata tttgcacgga aacagagcac 654481 tttgaagcgt ttcgtgatat caatctcgat tatttgaaaa tccctgtcga tgcctctgaa 654541 aaaatgaaag acgaattaat ggacaaattg gagccttatt catacgaaga gctgaaggac 654601 tttcaaacgg catatttggc cggttatatt gcggaaaagt acaattatac cgatgaggag 654661 ctttttccga gggcaaaaga gaaaatcagc agttatatag attcatacat ccattctact 654721 ttttccggat atacgtcagt caatgtgagg gacaaacata ttcacacgaa aaacgtgaac 654781 agcttttacg ttttgcttcc tgtttggatg gtcagttacg attatgaaag agcggagcat 654841 atctttgcga tgaacgggca aacaggaaag gtcgttggaa agccgccgat cagtcgagga 654901 aaagtggctg catggtttag cggaatagca ggcgggacat ttcttgcgtt gaagctcgtc 654961 tcattgatga tgggaggcgg attttgatgc gtggattttt tgggaaagcg atctttgttg 655021 tgctggctgt tttcatcatg atgcctttac tgggtatcga agcggtaaga gcctctgaat 655081 tgcagcagca tgtgtacgat cgcgctcatc tattgtcaaa agcggagatc ggaaaacttg 655141 aatctctctc ggcaaagctg ggtgcaaaga gggacactga tttcatcatt attacgacca 655201 aaagcacaaa cggtgaagat attgcagact ataccggcga tttttatgat cgttacggaa 655261 aaggcagtac agccattctg acgattgata tgacaaacag agaagtgttt atcgcaggct 655321 ttaaaaaagc cgaacagtat ttggacaaca gcaggctcaa tagcatcaga aatacgattt 655381 catctgattt atccaatgaa aattattttg aagcttttga gacatatatt cagctttcct 655441 ataaagatat gggcataaaa ccgggagtaa accctgacaa catattcttt acatggtggt 655501 ttcagctgat tgctgccatc gcagtcgggg gaattgcggt ttcaatcatg ctttatcatg 655561 caggcggcaa agtaacggtt aatggaagta catatatgga tcagcgtacg tctgatgtga 655621 ttgatcaata cgacacttat attagaacga ctgtaacaag agaaagaaaa ccatcagata 655681 aagacagcgg cagcgatggc ggtgttacga aaggcggcac gtcatacagt gggagccggg 655741 gcagttttta aatgtaagaa atagagaaag ggagaggcgt aatgtcgttt ttcagaaatc 655801 aattagcgaa tgtagtagag tgggaagaat ttagagatga tatgattttt tataaatgga 655861 acaatcgtga aatcaaaaaa gggagccgtt taatcattcg tcccggacag gatgctgtct 655921 ttttgaacaa tgggcgggtt gaaggagtct ttcaagatga tggcgattat gatattgaat 655981 cagaaattat tccattcctt tcaacgttaa agggctttaa gtttggcttt aacagcggca 656041 tgcgagctga ggtgctgttt gtcaatacga aggaatttac cgtaagatgg ggaacaaaac 656101 aggcgataaa tattccggca gcgggaatgc caggcgggat gcccattcgc gcaaacggca 656161 catttaattt caaggtgcag gactatatca gcctgattga taaaatcgct ggcgtgaaag 656221 atcaatattt tgtagaggat attaaaaccc gtatcatttc tattctggat cagcttctca 656281 tgaagtggat cacaagagaa gggaaagata tgtttaatct tcaagcaaac gcttttgata 656341 ttgccaaggg aattcaagag gacttagata tgcaattaat aagcgacggg atgacggtca 656401 ctggttttca aatcatgagc tttaattatc ctcaagaggt tcaagatatg attacaaaga 656461 acgcttccta cggtatggtt ggggatgtga acagatacca gcaaatatca atgacggatg 656521 gaatggcatc cggaaagatg agcggaagcg gagcggcttc ggatatggct ggaatgatga 656581 tgggaatgaa tatggccaat cagatgatga accaaatgaa tcagaatcag caggcacagt 656641 catcaggccc acagtcaact ggcagcggaa gcaaaccgaa tttctgtcca aactgcggaa 656701 caaaaacggg cgaagccaat ttttgtccga attgcggcca gaagcttgta taagaatcat 656761 acagtgaaaa gtccggagtg atcagcactc gggacttttt tatttaggag aataagcatt 656821 acctattgct tgctcctgaa caggccattt tcgagccccc gcttggataa ttcccagcag 656881 caattgacga cgttccttta ttgaattgac ggcaatttga aatgtttgct ttgataaagc 656941 cggtatgcct gattgttgaa gctttgagat gtctggttct ggcggcgctt gttctgcagg 657001 atggatatag gcagtatgaa cggtatccag atagtttttg atacttgagc gcgcttcttt 657061 gatatgaagc tgattcggct gatattgttc aggaattccg tatttgaaaa tggttagagc 657121 ctcatccaat acagcaacag ctataatgga tgattcctga tgctgcgtgc tgtggtaaaa 657181 atgaaggatg gggaaggcgt tatgctgagc ggtcagcttt cccagttctg atgaggcagc 657241 gacaagaaga aaatcaatgt cgtgaaaatc tttgccattc catgcattat ggacgatttc 657301 agttccgtca tgccctagac ttaatacact ttgggcaaag gagcgttttt gattaaccgc 657361 actcaagacg gaaatcaaat acgtgacaga aaatgtgatg gtaagcagtc cttgagctgt 657421 ttcaataatc gtgacaagct tccataggcc tccgttcgga gcgaggtcgc catttcctaa 657481 tgtaaacatg acatagccgg aaaaataaat tcggtctgac caggaagccg gttcttttga 657541 ttgagtttcc ataagtgagt gagggtcact cgagtaaatc aaaacccacc cgctccaaaa 657601 tagactgatc catatcacta acgtcaggca taacagcaga ggaccagcca tacttagaac 657661 ctttgcgtgg tcaccgctga ttttgcggca gcccttccac agccaggcag acaggcatct 657721 tgtgatcggg ccggcaccgc tctctaacca taacgtggtc cataaaaaat caatcatccc 657781 cgctgtcaat aataaaaggc ctgcaatgat ataaccctca ttcattttgg ttgcctccct 657841 taagtcagcc ttcttttatt ttcttctcta tttcctttta tcctgagtct gaaacaattg 657901 aacgaatgtt tgattttaca gagaaaaata ggtgggagtt acccaacact tactcatttt 657961 tcaatatgaa cagaaaatca caagattttt gacttgattc acacattttc atgaagaaaa 658021 acgttcattt tccccttgaa ttggtgattt tccttttata gagtaaaaaa ttttcagaaa 658081 tttatattga ctgaaagcgt ttttataatt atgataatat cagatataac aaaaatgtca 658141 ctataacatc actacaattg aactattaag tgactaataa ataccaaatg aacgaggtta 658201 tgcacaaaga aatgaccatt gttcttttaa cgagaaatga aatcgcttcc atagggattg 658261 acatgctaag aagaagggaa ggttatgagg ttattggata aaaacatgaa caactatttt 658321 ctgaagcctg cttacgaaat gtgaggaagg cagcagccct ggaataagtt tttgacatac 658381 gcattttgaa aaagactggg ggaaacagta tgaataaaca aggaaatcaa atgtcatttt 658441 tacgtacaat tattttagtc tccactttcg gcgggcttct ttttggctat gataccggtg 658501 tgctcaatgg agctttgccg tatatgggag agccggatca gcttaatctc aatgccttca 658561 cagaaggcct tgtcaccagt tcacttcttt ttggagcggc actgggtgct gtgtttggcg 658621 gcaggatgtc tgattttaac ggccgccgca aaaatatttt gttcctcgct gttatatttt 658681 ttatttcaac gattgggtgt acgtttgcac caaatgttac ggtcatgatt atttcccgtt 658741 ttgtgctcgg tattgcggtt gggggtgcat ccgtaacggt gcctgcctat ttagcagaga 658801 tgtctcctgt ggaaagcagg ggacggatgg tgacgcagaa cgaattgatg attgtatcag 658861 gacagctttt ggcctttgtt tttaatgcga tccttggaac aacaatggga gacaactccc 658921 atgtgtggag gtttatgctg gtcattgcgt cacttccagc cttgttcctg tttttcggca 658981 tgatcagaat gcccgagagt ccccgttggc ttgtttctaa aggaagaaaa gaagatgctt 659041 tgcgtgtatt gaaaaaaatc agggacgaaa aacgggcagc agctgagctg caagaaattg 659101 aattcgcttt caaaaaagaa gaccagcttg aaaaagcgac atttaaagat ctttcagtcc 659161 catgggtgcg ccgtattgtg tttattggat tagggattgc gattgtacag caaattacag 659221 gtgtgaattc gattatgtat tatgggactg aaattctaag aaattccggt ttccaaacgg 659281 aagccgcttt aatcggaaat attgcgaatg gcgtgatttc ggtattggca acattcgtcg 659341 gaatctggct gctgggaaga gtggggcgcc ggccgatgct gatgacaggc ttgatcggta 659401 cgacaacagc attattgcta atcgggatat tctcacttgt acttgaagga tcaccggcac 659461 ttccgtatgt agtcctgtca ttaacggtca catttcttgc ttttcagcag ggcgccattt 659521 caccagtgac ttggctgatg ctatctgaaa ttttcccgct tcgccttcgc ggactgggaa 659581 tgggtgttac ggtattctgt ctgtggatgg tgaattttgc agtcagtttc acgtttccga 659641 tattgctggc agctatcggg ctgtccacaa cgttctttat cttcgttgga ttaggaattt 659701 gctctgtctt gtttgtgaag aggtttttgc cggaaacgaa agggctttcg cttgagcagc 659761 tggaggaaaa cttccgcgct tatgatcaca gcggggcaaa gaaggattct ggggctgaag 659821 tgattggata atttaaaaaa gaatccgcac ccgagtgcgg attctttttg gtttcaaatt 659881 agttaggtct aacaaggatt ttgacttggc ttttctcttt aataagagcc ccgaagcctt 659941 cctcgatcaa atcatctagt acgatttttt tcgttacgag tttgtcggct gagaaatagc 660001 cttctttcat taatgacaat acagccggga agatgtcgcg gtatccgata attcctttta 660061 ctgtacgttc tttgattacg atatcgttcg gatggatttc agcacctttt tcccaaatgc 660121 tgacgatgac ggtttcaccg gcaattgtag tggactggat ggcttgtcgt aacaccactg 660181 ggacaccagt gacttcgaat gctacgtcaa caccgcctcc tgtacgttct gcaatctcag 660241 cgactacatc gtctgtttta gacggatcaa cgatgatcgc gccaagctcc tcagcttttt 660301 gctggcgttc aggagaaagc tcaacagcgt aaatatcagt tgcaccggca gccttcagcg 660361 cttcaatgac aagaagtccg atcgggccgc agccgaatac agccgctttg tcgcctgctt 660421 tgagtttgct tgagcggaca gcgtatagag caactgcaga aggttcaacg agcgcgcctt 660481 gttcatatga taattcatca ggaagtttga acaaaagctc ttcatccaca gagacgtatt 660541 cagagaaacc gccgcctccg ccggctaagc cgaggaatcc catttgttca tcaaggttgt 660601 aggcgccttg gtggccgtgt gtagcaaaaa tcggctcgac tacaacgcgg tctccaactt 660661 tataattttc aacgccttct ccgacttcga caacttcacc ggagaattca tgccccattg 660721 tgacaggtgc cgtttcattt gttaatgggt gcggtttgtc aaccggaata aagatcgggc 660781 cgcccagata ttcgtgtaaa tcacttccgc agatgccgca ccatttgact ttgatcttta 660841 cttttcccgg ctccgttttt ggctcttcga tatgttcaat acggatatcc ttttggttat 660901 gccatcttgc tgccttcatg gattaccact cctataactt ttgatgtgag taattccgca 660961 ccggtcaata tgaactgttc acaaaatcgc catttttaaa accaaaaaag aaatgaaatt 661021 tttatataat ataatctacg tttttttgaa aaaaagaaac tttaaagaaa aaagggtctc 661081 gcacactctt ttttctttat atgagagtat caatcgttta catagctatg aatttggttt 661141 gaacaatacg gtaatggttc gttcatattg aatgcgacaa ctactctatc aataattata 661201 actctaatac tgctattata ataggataat cttccatggt ttattttagc agaggtaact 661261 tttttgactt tgtaacatta ctgtaaggat attgaaataa aaaatagctg gttgatcgtg 661321 tataatcttc ctagatgtta acaaacaggg ggacgaaatg ttgaagaaag tcattttagc 661381 cgcttttatc ttagtaggaa gtactttggg agcttttagt ttttcatcag atgccagtgc 661441 gaaacatgtg aacggaaata ttacttggta taatggagtc gggaaaaaag gctcttcagg 661501 taagaaactt ggacattggg attgtgcgac caaaatcgga tttgatgttc ctagaaacgg 661561 gacaaaaatc agagcttatg caaaagcgaa gcctaaaaag gtgattacgg tttataaaaa 661621 tgatgttggc agaatgccta atgcagtgct ggatgttagc cctaaagcgt ttaaagcgct 661681 tggataccca ttaagcaaag gtaaagtagc ggggcattac agctattaat gtacatatat 661741 aatctggaaa gcaagaagtc acattcttgc tttttctatt ggtggagata aaagatgaaa 661801 aaaagaatca tattattatt agcagtgata atagcggcag ctgccgcggg ggttgcgttt 661861 tatgttgcaa aggataaagg ccatgagaag gctgctgatg tttcagtcaa taccgaaagc 661921 ggtgatgagc tgctggtttc aattacagat acggatctgc tgacaaagta ttatgaaaat 661981 gacaaggtga tccatgagga gaagctgacc agctatccgg catttgcctt ggatcaaaaa 662041 cagcaggtgc tctattatac gggcaataat gaacagaatg aaatgaggct ttttaaattg 662101 gatctgaagt ctcataaaaa aacgatgctt tataaaggcg cggagagtgc ggacagttta 662161 tttttatcaa aggaccgttc aaccatctat ttccgcttag gaaaagcgga cgaaagcaat 662221 tttcgaatcg ccgcttttga tctgaagacg aaaaagtata aaaatcttta tcctgccgct 662281 aatgatcagg atgacaccgt cagcagcttc ttttataacc aaaaaaacga ttcatttgca 662341 ttgcttcatt attctgtaga agaagactac aagaaaacag atgaagcaaa cgaaaagggc 662401 atcgaccctg aaccgacaac gattcatttt gcggaaggcc gccaaaataa atttaatgag 662461 ctgaaaagcc tgaaccaatt tatcagcgat attgctgttt ctgatgatga taaacgtatt 662521 ttattcacat catatacgca aaaaggaacg gagcaaaccg cttctattca aatgctcaat 662581 gcggatacga aaaaatatga aagcatcatc tcaaatcaaa aatcatttaa gctgttaatt 662641 gacgcacagc ctcagttttc taaggatggg aagaacattt attttcttgc cgaagccaag 662701 ggggctaaaa agctgaagga cgaaacaggg cgtgaagcta aggtgcggac gatttattcc 662761 tatagccttg agaataagac cttcaaaaaa gtatgggaaa atccgaacgg catcatcaac 662821 agcttttttg tgattaacta ataaaaacca ctcggcatga gctgagtggc ttttttaatg 662881 gatgaggtgc agggctaatg atccgagcca tttaaagata tgaatcagag gtaccgacaa 662941 aaacagaagt tcaacatatg agttcattgc aacattcagc tttttgaacg cagctctttt 663001 tttcaagtct ttttgctgct ggtttgagat cacgttatca ctcctcttat atccatatta 663061 taccattaaa acagacaaaa aagccctaaa cgtttacagt tttgggcttc tttcttcgta 663121 tttggcctct tgcaatgaga ggcttttatt ctgaaatata gaattttgtc tccgttcggg 663181 gtttgtttgc ttgcgggaga ctgcatttgt tatagggaag aactagcttg ttttcgtttg 663241 gctgttgttt tggagattca ctaatgaacg gatgccgtcg accattttac ttccgcacaa 663301 agggcacaat ggcgtatcac tgctggcgaa gttttttcgg gtccagccat tacagtcttc 663361 ttttgtgcat tcccaagtac tcacatcttc ctttggcagc ggttcttgat ttcgtttgtt 663421 atagtaagac ataaagtcac ttcttccctc atgtatttta ctgcacattt cctattgtct 663481 catacttttc cctaatctcc taattccttt ttctttatga ctttccaata accccatcta 663541 aaaaggagag gagtgtgctg ttaaaagcat ctggctcttc taaaaacggg caatggctgc 663601 ttttaggaaa ggtaacgagt gtcgcgtttg gaatattgct gcgcaagtgt tccccagctg 663661 ctgtagagaa aaatttcttg tcttccccga agcacagcaa tgccggcaca ttgatgtttt 663721 ggagggtgcc ccggtaatca gcggccgttt ggttaaataa aatcgtgcta gaaatggcag 663781 ccggctgttt gaggatttct gccagcatcc attctgtttc ggtctcggca ggcggttctg 663841 cgaacatatt ctggatgaag ctttcgtaga aaggcagcgg gtcagtttga atggcgtgca 663901 tcgctgtttt taagccgtca aaatcaaatg gaccatgttc ccagccctcc cattgatagt 663961 ccgaagcgga ttgatcgatg atcacagcgg cttgaatgtt atcattccca aactgattga 664021 gataatccca tacgacaaaa gcacccattg accagccggc aagaacgaca tgatcaagct 664081 ccattgcatt tagaaattcc cttatgtcac gggcatattg ggaaatggtg tggccgtgaa 664141 gcactttgtc agattcgccg tgtcctctaa gatcaagacg aatacattga taattggcag 664201 aaagcaccga aaattgtttg tggaaaaatt gtccgctcat cagcacccca tgtataaaca 664261 ggatcggcgt cccgctcccg tgtgtttcat agtaaaggcg tgtctgatct tctaatatga 664321 tgtatggcat gtttctcctc ctttagtttc catcatgagt atggctggct gctgttgagc 664381 tgatgatggc agctgtcgcg gctgcctgct gcgcttgaat gactgtttcg atagcggtgt 664441 atagtcctga ttccatcagc agatttttct ccatatgctc actgagatag aggctgacag 664501 caattttaaa gttcatttcc ttttgccatt taaaagcttt ttcctggttt aattcgtcag 664561 tgatgcacaa aacggttttg atatctggct cttccagaaa tgtgaggaga gcaaggtctg 664621 gataatgata atcctttgtt tttttgacag attcagtgat cgattgatat atctgtttgc 664681 aagcggaaac aagcatttcg ggctcttttt cactttgcaa ggccagaata tggctgacct 664741 gatgtaagta ctgtcctttt ttaaagccgt tggctgccag cagttgatag catgtttccg 664801 ccttctgtag cgcctgcaaa ccttttccgt tttctccaag cagtacggca agcggaacat 664861 tctgagttga agtgaggaaa taatgatttt tcttcatctg ctgataaaca gctagcccca 664921 tgttcatctg ttctttttgg tttgtcgttt cagatttgcc ggtgagcaag atcagagcgg 664981 aaaggtatgt gaacatatcc cgcttatacc ctagcttcac catttcattg tatacatcga 665041 tgaaagtctg aaatgtttgt tttgcctcat gctgaaaatg aatgtccaga atagatgcaa 665101 cagtaaagcg gtggtgtgaa ttgagtgttg agaagctgcc gatgtttgat ttgatatagc 665161 tgctcaaatc ataaaagcgc tgaaaatcaa actctctttt attcacaata tatgcagaag 665221 aaatgagcat taatatctga tcgtgtgaaa ctttccattt taattttgtt tttaattcag 665281 cataaatgga aatgtaatgc tttgtttttt catgtagatc gtgtgtgagc ataaaaagca 665341 gctccttttg ttgtttttac gtaatacgat aaatagggcc aaaggtttca taaagaaaaa 665401 acttgcctgc tagaggcaag tttgtcgggt tatttatggg gatcagttat atccatcggt 665461 ctcatcatgt catagtcttc atgctctaga atatggcaat gccatacgta tcgtccgctg 665521 tacggaccga atgtcgccgc gattctcagg acttcacctg catgcgcttg aatggtgtct 665581 ttccagccct tttcacttgg cggcggcggg acagccggac cggtatagga caattccccg 665641 ctttcttgat aacgggcgat atcaaacggc cgccggtcta atacacggaa ggagactaga 665701 tgcaggtgga tcggatgtgt tccgcgtgtc gggttgataa tggaccatat ttcagttgtg 665761 ccgacttttg gtgtttctgt gacgggatcg tgccagcgtt tgttattaag cagaaggacg 665821 ggtctgccgt attcgtcctg ggtgcctgcc agttttaacg ttctgatgtt ttgtattctt 665881 tcatgctgta ccgaagggta tgaggcgagg tacttcggct ttctgctttc gtctttttgt 665941 gccaatggtt ttgtgactct gaattgcatg atattcgcat ctgtttcagg attgacgtca 666001 ccgccgcagc ccgcgctgtt tgccaaaatg atcgattctc cttcatatgc tgtgaagtca 666061 atgatgatat cgtaacgttc agcaggcgca aggctgaaag aattcagttt aacagatcgc 666121 ggcaggagcc ctccatctga accaatctga ataaaatctc cgccattatc gagtgacagg 666181 ttataggttc ttgtattgga ggcgttgatg acacggaatc ggtatttcct tggctcgact 666241 tccaagtatg gccatacctt cccgttgacg agtatggttt ctccgcaaaa agccggaacg 666301 attgaaggat taggcagtga cggagaaggg ttttccggtg cgctcggata aaacaaagaa 666361 ccatcctcat tgatcgtgcg gtctgtgata agaagcggca catcgtattc gtctgaaggc 666421 agttttaagc gtttttcctt tgggtcatga atgatatatg caccgacaag tccggcatag 666481 acatttagcc tggtgagcgc catggcgtga tcgtgatacc acaatatagc cccgcgctgc 666541 tggtttggat aatgataaac ctctcttttg aaataaggtc ctgtttgttc aaagtctttg 666601 gaaaaccaag cctccggata cccgtcacta tcatctggcg tgacgccgcc gtgtaaatga 666661 acaacagtct ttacctcggg ctcttcatgc tggctgtcac tgtgatgaat ggtgtgatca 666721 atcggaagga aatgcgtgga aggaaggtta ttcatccatt ttacatatac gttttcattt 666781 cttttaacct caatggtcgg tcccggaaat aagccgttgt agccccacag gcgggttgga 666841 gggagatcgc gatggagctg atgagtgcat tcctccatgg tgacttcgta gtatgttttt 666901 tcttttgatt gctgtactgg ctttagtgta tctgggattg ggagagcatc cacaaatttt 666961 tcaagtgtca ttttcatctg tccttatcta aattttccaa attggtacta tagttaatga 667021 caataaggac gtgatggtta caaaaaatct tcgtgctgca gcccgcccga agaagaaaat 667081 aacaaaatcc taaacggcag gccgtttagg atttgatcag cattaaggca ggatatcggg 667141 ttgctgctgt gtgactgggt tggcagccgc tttctcgctc accttgcgtt ttctgaacac 667201 aaggtaagaa atcagaacga ttcccgtgat gacgcctgtc agcagcagct cgtctctcat 667261 ggaatcaata aacgccatgg acactaaaat tccgcaaatg gcgatgatgg tcaagtaggt 667321 taggaaaggg aagagccaca ttttgatctt caatgcttct gggtttgttt tttcgagttt 667381 tttccgcatt ttcagctggg aaacggcgat gacaagatag acgagtaaag cgattgcgcc 667441 tgatgagttg actaagaata aaaagacggt atccggtgaa aaatagttca ttacgaccgc 667501 gatataagag aaaaatgtcc cggccacaat ggcttgtacg ggaacgcctt ttttgctcaa 667561 tttcataaaa cggcgcggcg cttcatttct ttctgcaagt gaatacagca ttctggatgt 667621 ggtatacaaa cctgaattca ggcaagagag tacggctgtg aggacgataa agttcataat 667681 ctgtgcggct gcgggcactc ctatatgctc aagtacagcg acgaaagggc tttctaaaat 667741 atttgctgaa ttccatggca acagcgccac gacaatggcg attgagccca cgtaaaagac 667801 gatgatgcgc catacaacgg atctggtggc ttttgtcaca gattcgatcg ggttggatgt 667861 ttcccctgct gcaatggcaa cgatttcagt tcccataaaa gagaagatga caacgacaat 667921 gccgagcaat acggagctga tgccctccgg gaaaaatccg cctttgcctg taagattcga 667981 aaaaccgact ggctcactgc ccggtgcaaa gccaaaaata aaggcaaaac caacgattag 668041 aaaagcaatg atagtcacaa ctttaatgag ggagaaccaa tattcaaact caccgaaaga 668101 cttaacggag tagacgtttg tcagggtgag cacaatggtc aagatcaaac ttgtcagcca 668161 cagcggaata tcatggaacc agtattgaat aatgccagca ccggcaatgg cttcgatcgc 668221 tatgacgatc acccagaaaa accagtacag ccagccgatt gtaaatcctg cccacggtcc 668281 gatggcgtcg tgagcgtatt gagaaaacga tccgctcgtc gggtttacgg cagacatctc 668341 accgagcatt ctcataataa aaatcaccaa taatccggct aacgcgtaag aaacaacggc 668401 acccggaccg gtcgagtgaa tcactgaacc gctgcctaca aataggccgg ctccgattac 668461 accggcaatc gaaatcattg tcatatggcg ggtctttaat tcctttttta atcctgattg 668521 agactggttc ataagttacc tccttttaaa atgcaatcat tactgaatat tatgataatt 668581 gaaactctat cataaatata cagtttgtcg aaaattcgtg taagaaaata taccagctta 668641 tttcaaattt gtagtgtttt gtttgcgctt tcagcgaatg tgtggaaaaa atgtttcgtt 668701 ttttattcgc tgtgtgattt tgcgtaatat ttacaattcg atagaatgcg agaagcactg 668761 gtgtccttgg gtttgatggg atttttggcg gagcaaataa attggatgag agaaaaagtg 668821 ttccttcgtc actatttttc tgtggcgggt gaatcatgtt tctgtagacc cactgcggat 668881 cagctttgta agataataat aggaaaatgt gagcgagagg aggttttgta tggagagata 668941 tgatgaactg aaaaagggag aatccggagc gctggtcagc attgccgcgt atctagttct 669001 ttccgcaatt aaactgatca tcggttatct ttttcactcg gaagcactta cggcagacgg 669061 gttaaataac acaactgaca ttattgcttc tgttgctgtg ctgattggcc tgcgcatctc 669121 tcaaaagcct cctgacgaag atcatccata cggccacttt cgagcggaaa cgattgcatc 669181 gcttatcgca tcgtttatta tgatggttgt cggactgcaa gtgctgttca gcgccggaga 669241 atctattttt tctgctaaac aagagacgcc agatatgatt gcggcttgga cggcagcggg 669301 cggggcagtc ctgatgctga tcgtttaccg gtacaataaa aggctggcca aaaaggtgaa 669361 gagccaggcg ctccttgctg cggctgctga taataaatca gacgcattcg tcagtatcgg 669421 cacatttatc ggcattgtgg ctgctcaatt ccatcttgct tggattgata cggtcactgc 669481 gtttgtgatc ggtctgctta tttgcaagac cgcatgggat atctttaaag agtcatctca 669541 ctctttgaca gatggattcg acataaagga catttccgct tataaacaga caatcgaaaa 669601 aatctccggt gtgagccgtt taaaagacat aaaagcaaga tacttgggca gtacggttca 669661 tgttgatgtg gtggttgagg tatcggcaga tttaaatatt acggaaagcc acgatatagc 669721 caatgaaatt gagcggagaa tgaaggagga gcatgcgatt gattattcgc atgttcatat 669781 ggagccttta gaacaaaaat aatggagctt cctgtcacag gaagcttcag cgtgtcgaca 669841 aaccctcgca ttcgttgtca ggtctgcgct tcggtgctca cgaattagaa cattcgctcc 669901 gctcctatgc tcgtccttcc tagacttcaa gggttttcaa tcacgctgaa aagatgacaa 669961 aaccctaaaa tgaaagccat tttaggattt tgtcaacaat ctggagcttc ctgccacagg 670021 aagctttttt gtgtgttttg gccagcttta ttggtaacaa tttgctagaa tcgttttttt 670081 atacagattg ctttttgtgg taaagttagg ttacattatg atgaattttg tagatgacta 670141 ggaggaaaat aatggcatat caagaagacc tgcatccttt gctggggaaa gcagttgaac 670201 atattaatag agtaatggtt ggaaaacgag acatcgccat actcagctta gcagcccttc 670261 ttgccaaagg gcatgtgctg cttgaggatg tacccggagt cggaaaaacg atgatggtcc 670321 gcgcgctggc aaagtcaatc ggcgccgatt tcaaaagaat ccaattcact ccggatttgc 670381 tgccatctga tgtaacaggg gtatctatct ataatgcgaa aacgatggaa tttgaatatc 670441 gtcccggccc aattatggga aatatcgtgc tggcagatga aatcaaccgt acctctccga 670501 agacacagtc ggctttgctc gaagcgatgg aagaggggag cgtcacggta gatggccata 670561 cgatgcagct tgccgatccg ttttttgtga tggcaacgca aaacccggtc gaatatgaag 670621 ggacctatcc tttgccggaa gctcagcttg accgtttttt attcaaactt cggatgggtt 670681 atccgtcctt taatgaagag cttgacgtct tatctcttca ggaaaaaagc catccgattg 670741 agacgcttga gccggttatt gcaaaagaag acttcatctt tttacagagg gaagtgcaaa 670801 atgtccgtgc tgatgacagc attaaggaat atatcgttga aattgtgcag aaaacgagac 670861 agcatccttc tgttcaatta ggcgtcagtc cgcgcggctc aatcgccctc atgaaagcgg 670921 cacaggcata cgcgctgctg catcatcgcg actatgtcat accggatgat attcaatatt 670981 tagctccttt cacgctgccg caccggatga tgcttcatcc tgaggcaaaa tttgaaggga 671041 ttcaggcaga agcgatcgta agggagatca tgtcagctgt gaaggtgccg gttcaaaggt 671101 cggcggtccg ctgatgaata agaaatggca atggctcgta tatggttgga agctgattat 671161 attaacttta ttgacggctg ctgttttttc ttatgcgatg tttcagggcg gctttgtcag 671221 ctggtttttg ttttacgcgt ttctcccttt tgtcttgtat gccgggctgt tggccttgta 671281 tccgctccgt tcttttcagg cttcaaggca aatggataaa acacaattgc atgcggggga 671341 caggctgggc gtaacggtta cgctgagaag aaagctgcca tttccgctga tgtatatggt 671401 gattgaagat tgcctgccag aaggtatcga gtcattaaat cgagacggag ccgcggccaa 671461 acggctcgtt tttccttggt ttaaacggag catgacgatg tcgtatgaat tagctcgggt 671521 accgcgcgga gagcatcact ttcattctgt cagggtgcga accggggatg ttcttggctt 671581 gattgaaaaa acagcatttt ttgagctgga tgataccttg tttgtttatc cattctatca 671641 gcgtttttcc tatcaggtga atgagaggca tcaggaagac ggtgtaagcg gttcttctcc 671701 tattcatcag caccattcct cagtcgcagc aagtgtgcgg aattatcagc cgggagaccg 671761 gtttgctgcg ttagattgga agacatctgc acggcggagc cagctgatga cgaaggaatt 671821 tgagccttct cgcagcaaaa atctgtttct gctgatggac cgtttttcct cagacgcatt 671881 cgaagaggtc gtttcagtga cagcttcgat tcttcattct gttttaaaaa acggcgcggg 671941 tgctggtctg gcttccatcg ggaaggaaaa aaacattttc cctattcagg aaggggatca 672001 gcattttaag cacatgcttc ggcatttagc catcgctcat tgtgatgcgg cagacccgat 672061 aagccgatat gcacgggaag agctgggaaa gccatctgtt cgccaagctg atcaagttgt 672121 tgtcacggga cagttaacgg aagatatgct gcacctcgca gaaataggag gcggccgggt 672181 tacggtgata ctggcaaaag agaaagatgc tgagctctct caagctgaaa atgtcatgat 672241 tgaacgcatg atgaaacgcc aaatcagagt tcggatcatg aggggcgggc gagtttcgcg 672301 tgttgtttag aaagagaggt gactggttca catgccgcac gatgatcaca agggaagccg 672361 tttgagcttg ctgttatttt attttctggc ttttttattg ctgtgggagt ggcttaggcc 672421 gcttgacagt tttactgaaa cgaaacatac aggctttttt agtgtcttta tcggcttgac 672481 gtttctgctg acttttttca ggatgaggtg gtttgtcacc gttccttttt gtgtcatatt 672541 tacattgatc tcgatacaca tcctgtttta tcaaggatct atattcgact tgagctgggt 672601 cagctctttt ttgcaggatg tctatctgaa tatcacgctg attcaatcag ggcaatggaa 672661 tgacatgatt ccttcatttc ggaccctgct gttttttgtg ctgctgtggc tgctggtcta 672721 tctcctgcat tattgggtga tttaccagag aagaattttg tttttctttt tgatgacagt 672781 agcgtatatt acgattcttg atacctttac gccatatgat gccacttttg ccgtaatccg 672841 tatcgtgctg atcggcttct ttatgctggg ccttttatac ttggaacgca ttaagctgat 672901 ggaaagaatc acactgccaa aaacatctgt cctgaaatgg tttcttcctt tatctgtatt 672961 ggttttggct gcaacgggat tcggactcgc cgctccaaaa tcagagccgg cttggcctga 673021 tccggtgcct tttcttaaaa aaatcactca tcaagaccgc gtgtctgcag gggaaagcaa 673081 aatcggatac gggaatcatg atgaatcact cggcggcccg ttccagcagg atgctacacc 673141 tgtttttaca tggcagggaa aagagcgtac gtatttccgt gtggaaacga aggacacgta 673201 taccggaaaa ggctggattg aaacagacac aggcatgtcg tatcagctta gcaatggaaa 673261 agttgaaaat ctgtggtttg accataaggt tgcgacagag cgccgcaccg tccgtgtaaa 673321 agtcgataag cactacgggt ataaccatct gatgtatccg attggtgcgg aaaccattca 673381 gccaaagcag gctgtctcac ttgaaatgaa cggcaacacg gagcaaattt ctccgatcag 673441 tgaacaagcc ggtgaaatca gaaatatggg gaattataca gtaacgtaca attccccggt 673501 ctataagctg gatgaactga gaaaggtaaa agtgagaaaa aacagtgagg agtacacatt 673561 cagcgatcgc tacatgcagc ttccagattc actgccagag cgggtgagaa cccttgcgat 673621 caaactgact caggatcacg acaatatgtt tgataaggtg aaagcggttg aggactattt 673681 agggtcaaat gcgttcacat atgaaacaga aaacgtgacc attccgaaga atgatgaaga 673741 ttatgtcgat caatttctct ttgaaacgaa aatgggttat tgtgataact tttcttccgc 673801 catggtggtg ctcttgcgct cggccggcat tccggcccgc tgggtaaagg gttatacgtc 673861 cggcgaatac aaagaagcag ggaacaaaaa tggcagcatt tacgaagtga caaataacaa 673921 tgcccattcc tgggtagagg tgtatttccc ggaacagggc tgggttacat ttgagccgac 673981 taaagggttt acaaatccgg ctcaatttac atcttctgac acaaaagact ctggcagcga 674041 tagcagcagc tcgccgaaga aagcaaaaga gaaacagaaa gaagagaaaa aacagccgca 674101 aaaagaggaa aaacaaaagg aaaagcggga gccagctgtt tctaaaaagc cgtccgcttc 674161 gcatactaat gccggtgcgg gcttgtatgc agcgcttgcg gttcttgcag tcctcctggt 674221 ggcagctgta ttgctgtatg ttttccgctc gttatggatt cctgttttcg ccgtgaggaa 674281 attgaagcgg cgcagtgatc agcacgcgtt ttttgaggca tatggcgcgc tgctgaaaca 674341 actgaagaga aaaggactgc cgaaacgaga cagtgaaacg ctgcgtgatt atgcaaaacg 674401 aattgatgaa aaatacgaca tagaagacat gtcaaagctg acattaagct atgaaagggc 674461 gctttacaga aatgaagatt cttcggcgct atggaatgat tcgagagagt tatgggaaaa 674521 tttaattaaa agaagatggt cttgaccgct tatcgacgtg ttgttagaat tagtgaatat 674581 tatcggagtc tgggagcgag ttggcctgac tccggcaaac ggccttgcca aagagggcgg 674641 agcgagcttc atatctgtcc tcgttttttt ctgtgtcaaa aaacttagag gagattaggt 674701 gacaaccatg acaaagttag tgaatgaaat gattcttgtc cttgatttcg gcagtcagta 674761 taaccagctg attacacgcc gtatccgtga attcggtgtt tacagcgagc tgcatccaca 674821 tacattgacg gctgaagaaa ttaaaaaaat gaatccaaaa ggaattattt tatccggcgg 674881 tccaaacagt gtgtatgatg aaaactcttt ccgctgtgac gagaaaatct tcgagcttga 674941 tattcctgtt ttgggaattt gctacggcat gcagctgatg actcattacc ttggcggtaa 675001 agttgaagcg gcaagccagc gtgaatacgg aaaagcaaac atccgcatcg aaggcacacc 675061 tgatttgttc agagatcttc cgaatgaaca agtggtttgg atgagccacg gcgatttggt 675121 tgtagaagtt cctgaaggct tcactgttga cgcgacaagc catcactgcc cgaactcagc 675181 aatgagcaaa gcggacaaaa aatggtatgg cgttcagttc cacccggaag tgcgccactc 675241 tgaatacggc aatgatcttc tgaaaaactt tgtattcggt gtttgcgaat gcgaaggcga 675301 atggtcaatg gagaacttta tcgaaatcga aatgcaaaaa atccgtgaaa cggtcggaga 675361 caaacaggtt ctttgcgcgc taagcggcgg cgttgattcc tctgttgttg ctgttttgat 675421 tcataaagcg atcggcgacc agctgacttg tatctttgta gaccatggtc ttctccgtaa 675481 aggcgaagct gagggtgtta tgaaaacatt cagcgaaggc tttaacatga atgtgattaa 675541 agtagacgca aaagatcgat tcttaaacaa actaaaaggc gtttctgatc ctgagcaaaa 675601 acgcaaaatc atcggtaatg aattcattta cgtgtttgat gatgaagcgg acaagctcaa 675661 aggcatcgac taccttgcac aaggtacgct ttacacagat atcatcgaga gcggtacagc 675721 aacggcgcaa acgatcaaat ctcaccacaa tgtcggcgga cttcctgaag acatgcagtt 675781 tgagctgatc gagccgttaa atacgctctt caaagacgaa gtgcgcgcgc ttggcacaga 675841 gctcggcatt ccggatgaaa tcgtatggcg tcagccgttc ccaggaccgg gactcggaat 675901 ccgcgttctt ggcgaagtaa cagaagaaaa acttgaaatc gttcgtgaat cagatgcaat 675961 cttgcgtgaa gaaattgcaa atcacggctt agagcgtgat atctggcaat acttcactgt 676021 tcttcctgac atccgcagcg ttggtgttat gggtgacgca agaacatatg attacacaat 676081 cggaatccgc gccgttacat caatcgacgg catgacatct gactgggcgc gtatcccgtg 676141 ggatgtgctt gaagtcattt cgacacgtat cgtaaacgaa gtgaagcaca ttaaccgcgt 676201 ggtgtatgat attacaagta agccgcctgc gacgattgag tgggaataag aatcaattaa 676261 tggaaaccat ctttttggca attttgccgg gaagatggtt ttatttgttt attacgaaca 676321 aaatccgatt ttgcgcgact attgttcgct ttttgtattg ttttttcaaa atgaacttgg 676381 tacaatagac acagaaatca aataagatga attcgtataa tcgcgggaat atggctcgca 676441 agtctctacc aagctaccgt aaatggcttg actacgtaaa catttctttc gtttgatata 676501 aataaaacac ggttatttat tcaaactgaa atccgtctgt agtcaagcgt cccaaaatgt 676561 attgggacgt tttttatttg gcgttttcag gacagaataa atagcaaaga gtgaagggag 676621 tcaaatagct tgaaaacgtt ttttcagttt gatgagctgg gcaccagcta tcgcaatgaa 676681 atcattggcg gattaacgac ttttttatct atggcatata ttttgttcgt caatccgatt 676741 acgcttgctt tggagagcgt gaaagatttt ccggaggcgc tgagaattga ccagggtgcg 676801 gtctttacgg cgacagcgct ggcgtctgca gcaggctgta tcttaatggg attaatagcg 676861 agatatccga ttgccatcgc gccgggtatg gggctgaacg cgttttttgc gttttctgtt 676921 gtccttggta tgggtatttc atggcaggca gctttgtccg gtgtttttat ttcaggtctt 676981 attttcgttg ctctttcttt aacaggtttt cgtgaaaaaa tcatcaacgc cattccgcct 677041 gagctgaaat tggcagtcgg tgcggggatc ggcctgttta ttacatttgt tggattacaa 677101 ggttcaggaa tcattacagc gaatccttct acgctcgtca cgatcggaaa cattcacagc 677161 ggtcctgtgc tgttaacgat tttcggtgtg attgtcacgg ttattttaat ggtgcttcgc 677221 gtgaacgcag gcgtgtttat cgggatgcta ttaacagcgg tagccggcat gattttcggt 677281 ttggttccgg ttccgactca aattatcggc agtgtgccaa gccttgcgcc gactttcgga 677341 caagcgtgga ttcacctccc ggatattttc tctgtacaaa tgctgatcgt tattttaaca 677401 ttcttgtttg tcggattttt tgatacagct ggtacacttg ttgctgtggc aacacaagct 677461 ggtttaatga aggaaaacaa attgccgcgt gcgggccgtg cgcttttagc tgattcatct 677521 tctattgtga tcggtgccgt gcttggtacg tctacaacaa cttcttacgt ggaatcaagc 677581 tcaggtgtcg ctgcgggtgc ccggtcagga tttgccgcaa ttgtaacagg gattctcttt 677641 ttactggcta cgtttttctc gccgctccta tcagtcgtta cgtcaaatgt aacagcgccg 677701 gcgcttatta ttgttggtgc attgatggtg gcgccgcttg gcaaaatcgc ttgggataag 677761 ttcgaagtgg ccgttcctgc tttccttacc atgatcatga tgccgttaac gtacagcatc 677821 gcgactggta ttgccatcgg atttattttc tatccgatta caatggtgtg caaaggaaaa 677881 gcaaaagagg ttcatccaat catgtacggg ctgtttgtcg tatttatcct gtactttatc 677941 ttcttaaaat aaggaatgaa aaaccagctg cactggcagc tggttttttt gttgcaaaag 678001 ataaaaccat ttcatacgat ataccgtcat gtagatgtgc cgccatgctt tacttaaatg 678061 gaaatgactt gactgttcag gaaggcttcg gtaccttata taagtgtttt attttcttgc 678121 tgaatggtat tccgccgtat ttttttgata ggagttgctg acatgacgga agaaagaaaa 678181 gaaacgtttg aagaagaaat taaccagagt gaaagaatag atgcagatga agaaccgcta 678241 tcgagaatgt ccagaaaggc gagccggcaa agcaagcaga agcaaaaaca aaagcagaaa 678301 ccgcgccagg aacgcggtga atcaactgtt aaagacaagc ttgcgtctgt ttgggcagcc 678361 atcaacagat attgcggttt tgcgttctcg attttaaaat ctccggcgaa aactgtcgta 678421 acggatggtt tttctcatta taagtacggt ctgatttcaa tgcttatatt cagtatcatt 678481 ttttcaattg ggaattggtt tcagttaaag gcaagctgga atcggccgct cggtttcgga 678541 gaacgccatc atgctttcta tgacgggttt ttagttgttc ttgtgtattt gctgatcttt 678601 ttcgcggtaa tggtctttgc tatatgggct gtctcccgct atatgatgaa gcagaaggtg 678661 acgttcagag aagcggctgc cgtattgggt tcattgcttg tacccgtaat tgctgtttca 678721 atcctttggc tgatctttgc gatcgtaaat atcccaatgc tgacagtact gtttacggtg 678781 ctgatcttgt tttccatctt ttttatcatc gcgctgtatg tacagcgtgt gtaccaggcg 678841 gcacaagatg caccaattga ttatatctat tgtgtatttg cagtagttgc gatagcgctg 678901 ctgtttacgg cagtgacttg gccgtttatt tctgaatata ttacggcgtc gttgattccg 678961 ctttaatgaa aaaaccggct aatcctagcc ggttttttta tgtcacactt tttacaaata 679021 tatctaaaaa acatagttga tttgtaggat taacccgtgt atgatgggga aaatgctgaa 679081 aacgtccagc gcaaaaacct ttatgtttaa ggaggatgat ggacatggct gatgtacttc 679141 gccgagcaat taaccaaaag aagcaatttt taaaaaccaa attactgctc tcggaatttt 679201 atcaaggaag aggggaacag cttgctgact acacgctgag tgagcttgag aaagaataca 679261 agtcccttca gaaaatgaaa aaagagatct gacaatagat ataaagaggt gagtctgctg 679321 aaaagcgggc ttttttgttt tgattttgaa aaggcgagaa agagggtaaa ctactactgt 679381 tcaacacata aaagcgtgtc gaaatatttt gcttaagctt acgggcgaag ctgattgtaa 679441 acggctcatt tctctagtag aatatgaatg ctttgtgcaa gctgaagagt agggggatga 679501 ataaaatgat gcaaaccatc ttatcaaatg ggatagccat ggttctcata attctcatta 679561 ttaatattgt ctatgtgtca ttttttacga taagaatgat tttaacgctg aaaggacagc 679621 gttatttagc ggccggcatc agtacgattg aaatactggt ttatgtgaca ggactgagtc 679681 tggtgctcga taacttagac cagattcaaa atgtgatcgc gtacgcgctc ggttacggtc 679741 ttggcgtaat tgtcggcatg aaaatagaag aaaaattggc gcttggctat attatggtca 679801 atgtgattac gaaggagctc gatcttgatc ttccgaagca gctccgtgaa aaaggctacg 679861 gcgtgacaaa ctgggtggca ggcgggcttg aaggcgaccg cacagccctt cagatcctga 679921 cgccgagaag atatgaactc cagctatatg atacgattaa aacacttgat tcaaaagcct 679981 ttattattgc gtacgaacca aaaacaatcc acggcggctt ctgggtcaaa gcggtgaaga 680041 agaggagaat taaagaataa tggcaaagcc gaagaagaaa aagtttgaag tgacagagca 680101 gcaaacgatt gatgcggtgc ttcagcaaat gaaagaagaa ggatatctgc ctgtaaggcg 680161 aatggaagag cctattttta tggaaaaaaa ggaaaatggg tcaattcaga tcgttccgtg 680221 cgggaaaaaa atcgtatttg aagggaaatt gatctaaaac acgaacatta gtagaatgaa 680281 tttttgtatc gttcgataat atcgttgaca ttatccatgt ccgttgttaa gataaacatg 680341 aaatcaaaac acgacctcat ataatcttgg gaatatggcc cataagtttc tacccggcaa 680401 ccgtaaattg ccggactatg caggaaagtg atcgataaaa ctgacatgga tatatcgcag 680461 aagcgaacga ctgacgatac atgtaccatg cccggtttgt attgcttcct cataagtgca 680521 atgcagagcg ggtatttttt attttctgaa aacaaaagca ttagaaggtg gggaacagaa 680581 tgcagccgct agtaggaatc atcatgggaa gcacttccga ttgggagaca atgaaacacg 680641 catgcgacat acttgacgaa ctcaatgttc cgtacgaaaa aaaggtcgtt tccgctcacc 680701 ggacgcctga tttcatgttt gaatatgctg aaactgctag agaaagaggc atcaaggtga 680761 ttattgccgg tgccggagga gcggcgcatc tgccagggat gacggctgcg aaaacaacac 680821 tgccagtcat tggagttccg gttcagtcca aggcgctgaa cggaatggat tcacttcttt 680881 ccatcgtcca aatgcctgga ggcgtgcctg ttgcgacaac atccatcggc aaagcgggtg 680941 ctgtgaacgc aggcctgtta gcggcgcaaa ttttgtcagc atttgacgaa gaccttgccc 681001 gtaagctgga tgagagaaga gaaaatacaa aacagacagt gttagaaagc agtgatcagc 681061 ttgtctaaac aaatcatcta tccgggagct gtaatcggca ttatcggcgg cggccagctt 681121 gggaaaatga tggctgtgtc cgccaaacaa atggggtata aagtcgcggt cgttgatccg 681181 gtgaaagatt cgccgtgcgg gcaggttgcg gatgtcgaaa ttaccgctca ttataatgac 681241 cgtgaagcga ttcgaaaatt ggctgaaatc agcgatatca tcacatatga gtttgaaaac 681301 atcgactatg atgcgctgca ttggctaaaa gatcatgcgt atctcccgca aggaagtgag 681361 ctgctgctta ttacccaaaa ccgtgaaaca gagaaaaaag caattcaatc cgcgggctgt 681421 gaagtcgcac cgtacagcat cgtcaaaaca aagaatgaat tgaaacaggc agtacaggag 681481 ctcaggcttc cggcagtgct gaaaacatgc cgcggcgggt acgacggcaa aggccaattt 681541 gtgataaaag aagaggcgca aatggagcag gcagccgctc tgttagaaca cggaacttgc 681601 attcttgaaa gctgggtttc ttttaaaatg gaactgtcgg tgatcgtcgt tagatcggta 681661 aacggtgaaa tttcaacatt tccgacagct gaaaacattc accacaacaa tattcttttc 681721 caaagcatcg tgcccgcacg ggtagagaaa gggattcagc agaaggctgc tgatctcgca 681781 gttaagcttg cagatgagct taaccttgtc ggaccgcttg ctgttgagat gttcctgaca 681841 gaggacggag agcttttggt caatgaactg gcgccaagac cgcacaattc agggcattat 681901 acgctggacc tttgcgagac gagccagttt gagcagcata tcagagcggt atgcgggctt 681961 ccgcttggga agacagattt gctgaagccg ggcatgatgg tgaatcttct cggcgatgaa 682021 gtgaagcttg ttgaggaaga cccggagctt ttaaaagagg caaagctata tatatacgga 682081 aaacatgaaa tcaaaaaagg ccgcaaaatg gggcatatta catttatgaa gcagcctgaa 682141 gacgaatgga ttcaggagat cacaaataaa tggatgaata gagacggagg acaagcagaa 682201 tgatcgaacg ttattcaaga cctgaaatgt ccgcgatttg gacggatgaa aacagatttc 682261 aagcatggtt agaggttgaa attcttgcct gtgaagcgtg ggcggagctt ggcgtcattc 682321 cgaaagaaga tgtaaaggtt atgcgcgaaa acgcgtcatt tgacatcaac cgcattttag 682381 aaatcgaaaa ggacacgcgc catgacgttg tcgcttttac gcgcgctgta tccgaatcac 682441 tgggcgaaga aagaaaatgg gtgcattacg gcttaacgtc aactgacgtt gttgatacgg 682501 ctctttccta cttattaaaa caggcaaacg atattttgct caaggatctt gagagatttg 682561 ttgacattat aaaagaaaaa gcgaaagaac ataaatacac agtcatgatg gggcgcacac 682621 acggcgtaca cgctgagcct acaacattcg gcttaaaact tgcgctttgg catgaagaaa 682681 tgaaacgtaa tcttgagcgc ttcaaacaag cgaaagcagg catcgaggtt ggaaagattt 682741 ccggtgctgt cggcacatat gcgaacattg atccatttgt tgaacaatat gtctgtgaga 682801 agctcggatt gaaagcagca ccgatttcca ctcaaaccct tcagcgtgac cgccatgctg 682861 actatatggc aacacttgct ttgatcgcga caagcatcga gaaattcgct gtggaaatcc 682921 gcggactgca aaagagtgaa acacgtgaag tagaggaatt tttcgcgaaa gggcaaaagg 682981 gttcatctgc aatgccgcat aaacgaaatc cgattggctc tgaaaacatg acaggcatgg 683041 cgcgcgtgat ccgcggctac atgatgacag cttacgaaaa tgttccatta tggcatgagc 683101 gcgatatttc tcattcttca gcagaacgaa ttattcttcc ggatgcgaca attgcgctga 683161 actacatgct gaaccgcttc tccaacatcg tgaagaactt aacggtcttc ccggaaaaca 683221 tgaagcgcaa catggaccgc actctcggcc ttatctattc tcagcgtgtg ctccttgctt 683281 tgattgacac aggcctgact cgtgaagaag cctatgatac agttcagccg aaagcaatgg 683341 aagcgtggga aaaacaagtg ccgttccgcg agcttgtgga agcggaagag aaaatcacgt 683401 cacgtctttc tccagaaaaa attgctgact gctttgatta caattaccat ctgaaaaatg 683461 ttgatctgat ctttgaacgt ttaggtttag catagaagaa gcttttagcg gcttcttcta 683521 agccgccgca gtttgaaaat tcccaacatt cgggttagga ggccttccgt gaatattgtg 683581 aagaatgaac ttttatacga aggaaaagca aaaaagatct acaaaaccga tgacgaaaac 683641 acgctgtatg tcgtgtataa agactccgcc actgccttta acggcgagaa aaaagcagaa 683701 atcagcggaa aagggcgctt aaataatgaa atttcaagcc tcattttcaa acaccttcat 683761 gctaagggca ttaacaatca ttttatcgag cgcatttcgg aaacggagca gctcattaaa 683821 aaggtaacga ttgtgccgct tgaagtcgtg gtaagaaatg ttgtggcagg aagcatgtcc 683881 aaacgtctcg gcattccaga aggcacggag cttgagcagc cgattatcga gttttactac 683941 aaggatgacg cgctgggtga tccgctcatc acagaagatc atatttggct tttgaaggcg 684001 gcgactcctg agcaggtaga aaccattaag tccattacaa caatagtaaa tgaagagctt 684061 caaagcatct tcgacgattg tcatgtcaga ttaatagatt tcaagcttga attcggttta 684121 gatgcagaag ggcaagtgct tttggcggat gaaatatctc ctgacacatg ccgcttgtgg 684181 gataaagaaa cgaacgaaaa gctggacaaa gatttattca gacgcaatct gggaagctta 684241 accgacgcat acgaagagat tttcaataga ctgggaggca ttcatcatgt ataaagtaaa 684301 agtttatgtc agcttaaaag aaagtgtact agatccacaa gggagcgctg tccagcatgc 684361 cttgcacagt atgacttaca acgaagttca agatgtgcgc atcgggaaat acatggagct 684421 taccattgaa aaatctgacc gtgatcttga cgtgctagtg aaagaaatgt gcgaaaaact 684481 tcttgcgaac acagtgattg aagattatag atatgaggtt gaggaggtag tcgcacagtg 684541 aaatttgcgg tgattgtgtt acccggctcc aactgtgata tcgatatgta tcatgctgta 684601 aaggatgagc tcggccatga agtggaatac gtctggcatg aggaaacaag ccttgacggc 684661 ttcgacggcg tgttaattcc gggaggattt tcttacggcg attacttaag atgcggcgcc 684721 atcgcccgat ttgcgaatat tatgccagct gtcaaacaag cagcggctga aggaaaacct 684781 gttcttggcg tctgtaacgg attccagatt ttacaggagc ttgggctgct gccaggcgca 684841 atgagacgca acaaagatct gaagttcatt tgccgtccgg ttgaattgat tgttcagaac 684901 gacgaaacct tattcacagc ttcctacgaa aagggagaat cgattacaat cccggttgcc 684961 catggtgaag ggaatttcta ctgtgatgac gagacgcttg ctacattaaa ggaaaacaat 685021 caaattgctt tcacatacgg ctctaatatt aatggaagtg tcagcgacat tgccggtgtc 685081 gtgaatgaga aaggcaatgt attaggcatg atgcctcacc ctgagcgcgc ggtcgatgaa 685141 ctgcttggaa gcgccgacgg tcttaaattg ttccagtcta tcgtgaaaaa ttggagggaa 685201 actcatgtca ctactgcttg aaccaagtaa agaacaaata aaagaagaga aactgtatca 685261 gcaaatgggt gtcagtgatg atgagtttgc attgatagaa tccattcttg gaagattgcc 685321 gaactacaca gaaatcggaa ttttttctgt catgtggtct gagcattgca gctataaaaa 685381 ctcaaagccg attctgcgta aattcccgac aagcggcgag cgtgtgctgc aggggccggg 685441 ggaaggcgcc ggaatcgttg atatcggtga taaccaagcg gttgtgttca aaattgaatc 685501 acataaccac ccatcagctc tcgagcctta ccaaggcgct gcgactggcg taggcggaat 685561 tatccgtgat gtattctcaa tgggtgcacg cccaatcgct gtattgaact ctcttcgatt 685621 tggtgaactg acttcacccc gcgtgaagta cttgtttgaa gaagtagtag cgggtatcgc 685681 cggatacggc aactgtatcg gcatcccgac agtcggcgga gaagtgcagt ttgacagcag 685741 ctatgaagga aatccgctcg tcaacgcaat gtgcgtcggt ttaatcaacc atgaagacat 685801 caaaaaaggc caggcaaagg gtgtcggcaa cacagtaatg tacgtaggag cgaaaacagg 685861 gcgtgacggc atccacggcg ctacgtttgc ttctgaagaa atgtcagact cgtctgaaga 685921 aaagcgttct gctgtccaag tcggcgatcc gtttatggag aagcttttgc ttgaagcatg 685981 tctggaagtc atccaatgcg acgccttagt cggcattcag gatatgggag ctgccggttt 686041 aacaagctca agtgcagaaa tggcaagtaa agccggttct ggcattgaaa tgaatcttga 686101 cctgattcct cagcgcgaaa caggcatgac cgcgtatgaa atgatgcttt ctgaatcaca 686161 agaacggatg cttttggtta ttgagcgcgg acgtgagcag gaaatcatcg atatttttga 686221 caagtatgat cttgaagcgg tttctgtcgg acatgtgaca gatgataaaa tgcttcgcct 686281 gacacataaa ggagaggttg tgtgcgagct gcctgttgat gccttggcag aagaagcacc 686341 ggtttaccat aagccttctc aagagcctgc ttactatcgc gagtttttgg aaacagacgt 686401 tccggctccg caaattgaag atgcgaatga aatgctgaag gcccttcttc agcagccgac 686461 gattgcgagt aaagagtggg tttatgatca gtatgactac atggtgcgca cgaatacagt 686521 tgtcgctcct gggtctgatg ctggtgttct cagaatccgc ggaacgaaaa aggcgctggc 686581 gatgacgaca gactgtaacg cgcgttatct ctatcttgat cctgaagtcg gagggaaaat 686641 tgctgtcgct gaagcagcgc gcaacatcat ttgctcaggc gcagaaccgc ttgcggtgac 686701 agataacctt aacttcggaa accctgagaa gccggaaatc ttctggcaga tcgaaaaagc 686761 ggcagacggc ataagcgaag cgtgcaatgt tctcagcact ccggttatcg gcggtaacgt 686821 atcgctttat aacgaatcaa acggcacggc gatctatccg acaccagtta tcggcatggt 686881 cggcctaatt gaagatacag cgcacattac aacacagcat ttcaaacaag caggagatct 686941 cgtatacgtg atcggcgaaa caaaaccaga gtttgccgga agcgagctgc aaaaaatgac 687001 agaaggccgt atttacggca aagcgccgca aatcgatctt gatgtagagc tgtctcgtca 687061 aaaagcactg cttgacgcga ttaaaaaagg cttcgttcaa tctgcgcatg atgtgtctga 687121 aggcggctta ggcgtagcga ttgcggaaag tgtcatgacg acggaaaacc ttggcgctaa 687181 tgtgactgta gaaggggaag cggcgttatt attctctgaa tctcaatctc gcttcgtcgt 687241 ttcagtgaaa aaagaacatc aagctgcgtt tgaagcaact gtcaaagatg cagttcatat 687301 tggtgaggta acagctgacg gaattctggc gattcaaaac caagacggac aacaaatgat 687361 tcatgcgcaa acgaaagagc ttgaacgcgt atggaaagga gctatcccat gcttgctgaa 687421 atcaaaggct taaatgaaga atgcggcgtt tttgggattt ggggacatga agaagccccg 687481 caaatcacgt attacggtct ccacagcctt cagcaccgag gacaggaggg tgctggcatc 687541 gtagcgactg acggtgaaaa gctgacggct cacaaaggcc aaggtctgat cactgaagta 687601 tttcaaaacg gcgaactcag caaagtaaag ggaaaaggcg ctatcgggca cgttcggtac 687661 gcaacggctg gaggcggcgg atacgaaaat gttcagccgc tcctcttccg ttcccaaaac 687721 aacggcagcc tggcgcttgc tcataacgga aatcttgtca acgccactca gctgaagcag 687781 cagctcgaaa atcaagggag catctttcaa acctcttcgg atacagaggt tttggctcac 687841 ctgatcaaaa gaagcggaca cttcacgctg aaggatcaaa ttaaaaactc gctttctatg 687901 ctgaaaggcg cctacgcgtt cctgatcatg accgaaacag aaatgattgt cgcacttgat 687961 ccaaacgggc tgagaccgct atccatcggc atgatgggcg acgcttatgt ggtcgcatca 688021 gaaacatgcg catttgacgt cgtcggcgca acgtaccttc gcgaggtaga gccgggagaa 688081 atgctgatca ttaatgatga aggcatgaaa tcagagcgtt tttccatgaa tatcaatcgt 688141 tccatttgca gcatggagta catttatttc tccagaccag acagcaatat tgacggtatt 688201 aatgtgcaca gtgcccgtaa aaaccttggg aaaatgctgg ctcaggaatc cgcagttgaa 688261 gctgacgtcg taaccggggt tccggattcc agtatttcag cggcgatcgg ctatgcagag 688321 gcaacaggca ttccgtatga gcttggctta atcaaaaacc gttatgttgg cagaacgttt 688381 attcagccgt cccaggctct gcgtgagcaa ggcgtcagaa tgaagctgtc tgcggtgcgc 688441 ggggttgtag aaggcaaacg cgtcgtgatg gtggatgact ctatcgtgcg aggaacaact 688501 agccgccgga ttgtcacgat gctaagagaa gcgggtgcga cagaggtgca tgtgaaaatc 688561 agttcaccgc cgatcgctca tccgtgcttt tacggcattg acacttccac acatgaagaa 688621 ctgatcgcgt cttcgcattc tgttgaagaa atccgtcagg aaatcggagc cgataccctc 688681 tcatttttga gtgtggaagg gctgctgaaa ggcatcggca gaaaatacga tgactcgaat 688741 tgcggacagt gtctcgcttg ctttacagga aaatatccga ctgaaattta ccaggataca 688801 gtgcttcctc acgtaaaaga agcagtatta accaaataaa acttgaaaaa tgacataaag 688861 gcagcgcagt tcggctgcct ttctctttct gccctcgttc ggggagatat tttgaaaagc 688921 gccttaaagg agtgaatagg atgtctgaag catataaaaa cgcaggagtt gacatcgaag 688981 ccggatatga agctgtaaaa cgaatgaaaa aacacgtgga gcgcacgaaa cggcttggcg 689041 ttatgggcag ccttggcggt tttggcggca tgtttgacct gtctgagctt tcttatcaaa 689101 aaccagttct catttcggga acggacggtg tcggcacaaa attaaagctc gctttttcca 689161 tggataagca tgacacgatt ggcgtggatg ctgttgcaat gtgtgtcaat gacgtgctgg 689221 cacaaggtgc agagccgctg tttttcctcg attatttagc ggttggcaaa gcggacccag 689281 tgaaaattga acagattgta caaggtgttg cggaaggctg tgagcagtca ggttcagcct 689341 tagtcggcgg tgaaacggct gaaatgccgg ggctctatac agctgatgaa tacgatattg 689401 ccggtttctc agtcggagtg gcagaaaagg acgaaatcgt gactggagaa aaaattgaag 689461 agggccatct gttgatcggc ctcagctcca gcggccttca cagcaacggc ttttcccttg 689521 tcagaaaagt gcttctggat gatgcggagc tggacctcga tacaacatat gagccgtttg 689581 aacgcccgct tggcgaggaa ttgcttgaac cgacaaggat ttacgtgaag cctgtgcttg 689641 ccgcggtcaa aagcggaaaa atcgacggca tggcgcacgt gacaggcgga ggatttattg 689701 aaaatattcc gcgtatgctt ccggaaggct taagtgcgga aattgatcat ggctcatggc 689761 cgatcccgcc gattttttct ttcttgcaag agtacggcaa gctaaaggaa gaagacatgt 689821 tcaacgtctt taatatgggt atcggttttg ttttggcagt caaagaagag catctgacag 689881 atgtgatcgg aacgcttgaa agccatggcg aaaaagccta tttaatcggg cgtgtgaaaa 689941 aaggtgaagg cgtcacattc ggcggtgcgg cactttcatg aaaaagtttg cggtatttgc 690001 atcaggaaac ggttcaaact tcgaagccat cgtcacgcgt ttgaaggagg agaactggga 690061 tgcgtcagca gcgctcctcg tttgcgacaa accgcaggcg aaagtcatcg aacgggcgga 690121 agcattccac attccatcct tcgcatttga gccgaagtct tatgaaaaca aggctgcatt 690181 tgaacaagcc atcattgaac agcttcgtct tcacgaggtt gaattgattg ctcttgccgg 690241 ctatatgagg ctgatcggtg atacgctcct tcaagcatat gggggaaaaa tcattaacat 690301 tcacccatcg cttcttccgg cgtttcctgg aatcgacgca gtcggacagg cgttccgggc 690361 gggtgtgaag gtggccggaa tcaccgtgca ttatgtcgat gaaggaatgg atacaggtcc 690421 gatcatcgct caaaaggcaa tcgaaattga tgaacatgat acattggaaa caatcgaaca 690481 gcgaattcac aagcttgagc ataaatggta tccgagtgtg attaaacagc tattaggatt 690541 aaataacaga ggtgaaaagg catgaccatt aaacgtgcat taatcagtgt ttcagataaa 690601 acaaatctcg ttcctttcgt aaaagaactg acagagcttg gcgttgaagt catctccaca 690661 ggcggaacga aaaagcttct tcaagaaaac ggtgtggatg tgatcggaat ttctgaagtg 690721 acaggctttc ctgaaattat ggacggccgg ttaaaaaccc tacacccgaa tattcacggc 690781 ggccttctgg cggttcgcgg caatgaagag catatggcgc agatcaatga acacgggatt 690841 cagccgattg acctcgttgt cgtcaacctc tatccattta aagaaacgat ttctaaagaa 690901 gacgtcacgt atgaagaagc gatcgaaaat atcgacatcg gcggacctgg catgctgcgc 690961 gcggcatcaa agaaccatca ggatgtcacg gttatcgtcg atccggccga ttacagccca 691021 gtgctaaatc aaatcaaaga agaaggcagc gtatctcttc agaaaaaacg cgagctcgcg 691081 gcaaaagtat tccgtcatac tgcggcatat gatgcactga tcgctgacta tctgacaaat 691141 gttgtcggtg aaaaagaacc agagcaattc actgtgacat ttgagaaaaa acaatcgctt 691201 cgctatggag aaaacccgca tcaggaagca actttctatc aaacagctct tcctgtcaaa 691261 ggctccattg cgcaagcaga acagcttcac ggaaaagagc tttcttacaa caacattaaa 691321 gacgcggatg ctgcagttca aatcgttcgt gaattcactg aaccggctgc tgttgctgtg 691381 aagcatatga acccgtgcgg cgtgggaaca ggaaaaacga tcgcagaagc gtttgacaga 691441 gcgtttgaag cggataaaac atctatcttc ggcggcatta tcgcgctgaa ccgtgaagtg 691501 gacaaggcaa ctgccgaagc gcttcacaac attttcttag aaatcatcat tgcgccttca 691561 ttcagccaag aagcgctcga cgtcctgact gcgaagaaaa atctccgtct gctgacgctt 691621 gacgtatccg ccgctgttca aaaggaaaaa cagctgacat ccgttcaagg cgggctgctg 691681 attcaagatt tagatatgca cggcttcgat gatgctgaga ttagcattcc gacaaaaaga 691741 gagccgaacg agcaagagtg ggaagacttg aagcttgctt ggaaagtcgt gaagcatgtg 691801 aaatcaaatg cgattgttct cgcgaaggac aacatgacag tcggcgtggg agcaggccaa 691861 atgaaccgcg tcggatcggc aaaaatcgca atcgagcaag caggggaaaa agcgaagggc 691921 agcgcgctcg gttcggatgc atatttccca atgccagata ctgtcgaaga agcggcaaaa 691981 gcgggcgtta cagccatcat tcagccaggc ggatcgatcc gagatgagga ttccatcaaa 692041 aaagcggatg aatacggcat tgccatggta ttcaccggca tcagacactt caaacattaa 692101 ggggatgaaa acgacgtgaa tgtattaatt atcggtaaag gcggaagaga acatacgctg 692161 gcgtggaagg cagcgcaaag cagcctcgtc gagaatgtat ttgccgctcc cggaaatgac 692221 ggcatggcag cttccgctca gcttgtaaac attgaggaaa gcgaccacgc agggcttgtc 692281 tcatttgcaa aacaaaatca ggtcggcctg accattgtcg gccctgaggt tcctttaatt 692341 gaaggtctgg tggatgaatt cgaaaaagcg ggcttacatg tgttcggtcc gtcaaaagct 692401 gcggcgatca tcgaaggaag caaacagttc gctaaggatt taatgaagaa atacgacatt 692461 ccgaccgcag aatacgagac gtttacatcc tttgatgagg cgaaggcata tgtgcaggaa 692521 aaaggtgctc cgattgtgat aaaagcagat ggacttgcag ctggaaaagg cgttactgtg 692581 gctatgacag aggaagaagc aattgcgtgc ttgcatgact ttcttgaaga tgaaaagttc 692641 ggtgatgcga gcgcgtccgt tgtcattgaa gaatatcttt ctggtgaaga attttctcta 692701 atggcctttg tcaaagggga aaaggtgtat ccgatggtga ttgcccagga tcacaagcgg 692761 gcgtttgacg gagacaaagg cccgaataca ggcggcatgg gcgcctactc gccagttccg 692821 caaatttcgg aagaaacggt ccgccatgct gtagaaacga tcgttaagcc ggctgcaaaa 692881 gcaatggtac aagaaggccg ttccttcact ggcgttttgt acgctggatt gatgcttact 692941 gaaaacggct cgaaggtcat tgaatttaat gcccgtttcg gcgatccgga aacacaggtc 693001 gtgcttccgc gcatggaatc tgatctggta caggtgcttc ttgatctttt agatgataag 693061 gaagttgact taagatggaa ggataccgcg gcagtgagtg ttgtgcttgc atcagaaggg 693121 tatccggaaa gctatgcaaa aggcacgccg atcggcagcc ttgcagcaga aactgagcag 693181 gtcgtggtct tccatgccgg aacgaaagca gaaggtggag agttcgttac aaacgggggg 693241 cgcgtcgcca atgtgacggc ttttgatgaa acgtttgaag cggctagaga ccgagtgtac 693301 aaagcggttg atgaaatttt caaaccggga ctctttttca gaaaagacat tggggcacgc 693361 gctttaaagg ctgcccaaaa ataagtgagg aaaacccgca gaatagctgc gggttttttg 693421 ttatcaaaaa gcgggatggc agctagaaga agaaagcaca acgagcgtgg ttggttttcc 693481 atgggccatc gaggtgtcaa taaaatcctc aagcgtatgt accgattcag tcacgacctt 693541 tgtcacatag ctgtacatcc ccgtgatgcg gtggttttct gctacatcag gatgcgatgt 693601 tgcaaaggcg gcgtagtgct tgcagctttt cggctccatg agaataaaag cggtgacatg 693661 cttgtttagt ttttcgtaac agatattcgc gctgtagccg gtaatcactc ctttgtcttc 693721 cagcttcctg acacgctccg ccgcgcttgg cgagctgagt ccgacaagct ttcccagctc 693781 aaccatcgtt aatctgccgt ttcgctgcaa atgcgagaga atctgaaggt ctgtatcgtc 693841 catttgtctg gctcctttac atatttaggc gaatgaatga aaattccttt gatcgtaagg 693901 taatgctgtt gatttaactt cattgtagca tatggatgcc gtcttatttt ttctataata 693961 aagccatcaa tcagagaggg ggcatcatgt tgccagaatt gcagcgctct attacttgga 694021 tacaagggac ggcgttaacg attggggcgg ttttaggatg cgggatatta atcctgccgt 694081 ctgtcaccgc ggacacggcc ggccccgctt ctttatttgt ttgggtgttc atgtccttct 694141 tatccttttt tcttgtcggc acgctggccc ggcttgtgaa aatagcgcct agcgcgggag 694201 gaatcacggc ttatgtgcag ctggcctttc agaaaaaagc cggggctatt ttgggctgga 694261 tcatgttagg gtccgttccg atcggcgttc ccatcatcgc tttgactggc gcgcattacg 694321 tcagttacat cacagaggcg gccgattggc agattacatt gattgctggt tgcatgctgg 694381 ctatatctat tttgcttcat atgagaggga ttcaactatc agcaaacatt agtacactcg 694441 ttatatgtgt catcgtattt ctgcttgtca cttctattgc tgtgtcattg ccacacgtca 694501 cgatagcaga attcaagccg tttcttccgc atggctggtc tgccgctgga tctgtttctg 694561 ttatgatttt tttctctttt gtaggctggg aaatgattac cccgttggct gaggaatttc 694621 atcgtcctga aaaagatgtc ccgctcagct tgtttttggc agcgtcttgt gtggcggggc 694681 tgtatatcat gctgtcattt gtgaccgtgg gtactcattc atatggagag aatggagaaa 694741 ttgcatcgct tgccatgctc atttcaaaag gagcaggaga aagcggtgta tatgtcacgg 694801 tatgtttagc gctgtttatt acattcgcca ccatccatgc caatattgcc ggtttttcaa 694861 gaatggtgta cgcattggcg agagaggggc acatacccgt attttttgga aaactcagtg 694921 cgacaaaacg tacgcctatt cgcgttttga cagcgatggc cgcagtgttt ggcttagtgc 694981 ttgcagcgca tggtctgttt caaatcgatt tgacgactct gttgaaaggg ccgagcgcgg 695041 cttttatcgc atcttacata tgtacaatgg cggcagcact gaaactgctg ggcaggagag 695101 atataggctg gtggatggcg ctcggggcat ttgtggcgtg cgcggtgatt tattcattca 695161 gcggctgggc actgctttat ccggcagtgc tggcagctgc aggatatttc tatatgaaaa 695221 caaagggtgg gcataaaaaa aagcttgatc acgttttgtg atcaagcttt tccatttatc 695281 cgttttgatg ctcgttattt ccagaatcgc tgtgttgaaa catgtaggtc acaggacaga 695341 agcgcaagat tcccgaaccc gctttcatgg cccccataaa gatgtaaaag agatgcattc 695401 tgcaccaagg ttttttcgta aactttgcac tggcggctga cataatcgtc aatccgcagg 695461 cgattctgaa cacggcattg atgagactga tgtttggctt caaggaaatc cgctcctttt 695521 acttaaaaaa gttttttaat cgaaccttca aaaatttgta acgtttttat cgtgcgtgat 695581 gaggaaggat gtgataccat gagtctaata catgtaaagg agagtatgtg aatgtccgaa 695641 cgcaccttta actggaaaaa caaagacatc agggcacagg ttgatgttgt agactcaaag 695701 ctgcttccaa cgctcctttt acggaatgct ctcgtcttaa atccatatgt aaaacaatgg 695761 ctgaaaaaaa acatttggat ttatcaggac cgcattgttt atgtgggtca tgaacttccg 695821 aatagagccg aagaaattca tacgattgat tgtgaaggaa aatacattgt gccaggttat 695881 attgaaccgc acgcacatcc ttttcaaata tataatcccc aaacactggc ggaatatgtg 695941 tctcaatacg gaacaacgac attcgtgaat gataacttat ttttgctttt gcaaagcgga 696001 aaaaagaaag cgcttacgat tttgaatgaa ctcaaaaagc agcctgtcca gtatttttgg 696061 tggtcacgct atgacctcca gaccgaggtt ctgaacgagg accacgtcct tccatttgac 696121 gtcagaaaac agtggattga acatccggat gtgattcaag gcggagaaat gaccggatgg 696181 cctcgcctgg tagatggtga tgatttaatg ctccactgta tgcaagctac aaagaaacag 696241 agaaaacgta ttgaagggca ttttcccggc gcttctgata aaacgcttac aaaaatgaag 696301 ctgttcggtg cggattgtga tcatgaagcg atgacaggtg atgaagtgat gagaaggctg 696361 gaactgggct attatgtttc ccttcggaac tcttccattc gccccgatgt aagaaaaatc 696421 ttgcaagagc tgcatgagaa gggcttccgc tattatgacc acttctttta cacgacagat 696481 ggcgcaaccc cgaatttcta taaaggcggc atgacaaacg agctgattcg cattgcgtta 696541 gaagaaggcg tacctgcaat cgacgcctac aatatggcat catttaatat cgcaaagtat 696601 taccaaatgg atgattattt aggagttgtc ggaccgggca gactggcatc gctaaacata 696661 ctggaagatc cgttaaatcc gaatccagtg actgttctgt caaaagggac cattctgcgt 696721 gaaaacggct gtgatttgaa ggcgtttaca aagacggact ggcacaaagg cggtcttgtc 696781 ccgcttgagc tttcatatga tatgacgatg gatgacttgc agttttctat gccgatgggc 696841 gtgaaaatgc ggaatgcggt tattatggag ccatatatga ttgagatcga caattcgatg 696901 gaacagctct cgtttgacca tgatgaaagt tatttgacga tgctcgacag acacgggaaa 696961 tggcgcgtca atacgatgat aaaagggttt gcctcaagcg tgcagggatt tgtaagctcc 697021 tttacgacga cgggcgacat tgtcgcgatt ggaaaaaata aagcggatat gctgctcgct 697081 ttcgcccgca tgaaagaaat cggaggagga attgttttag cggagaacgg aaacattctg 697141 catgaaatcc cgcttgcgct gtgcggctgc gcctcttcgg aagcgtatga agacgtgctt 697201 gagaaggaac aaaagctgag agatcttttg actgaaagag gctatgagtt ttgcgatcct 697261 atctatacgc tgctcttttt gcaaagtacg caccttccgt atatacgcat tacgccaaga 697321 ggaatattcg acgtcatgaa aaaaactgta ctctttccat cgataatgcg ttaaaatata 697381 aaagagcagg gagccgacat atgaaaaaat ggatgacagt ttgcgcgctg tgtttcgtgt 697441 tttttctgct ggtatcctgc cagcagaagg atgctgtccc ggatactgca aagaagctga 697501 aagctccttt aacggggcta aagactgaac agaaagtgac tgaacgccgc cctgttgctg 697561 ttgtggtgaa caatcacccg aaggcgaggc cgcagtcggg tctgtctaaa gccgacattg 697621 tcatagaagc gctagccgaa gggcaaatca caagatttct ggccattttc caaagccaga 697681 tgcctgaaac tgtcggacct gtgcggagcg cgcgggaata tttcgtcact ctcagcaatg 697741 gctttgacag catatttgtc catcacggct ggagtcccgg cgccaaaaag cagctggaat 697801 ccggagctgc cgattatatg aacggattgg attttgacgg aagcttattt tggagagctg 697861 atttcagcaa accgccccac aattcctata cgtcttatga ttacataaaa aaggcggcag 697921 aacaaaaggg ttataagctg aagcaggaaa caaatccgct gctgtttcaa acatcagatg 697981 caaaacctgc aaatgaatct tacaatgttc gggtagatta tggaacaaat aacgttacaa 698041 atcttgtcga atacaactat gataaaaaag ctgaatttta tacaagaagc tctgatggtg 698101 tcataacgac agaccgggaa accggaaagc cggttgcaat gcaaaatatt ttcattgttg 698161 aagccagcca tcatattatt gatcaagatg gaaggcggga catcgacttg gaatcaggag 698221 gaaaaggtct gttgtttcag cacggaaacg tcattgaaac agactggaaa caagtgaatg 698281 gcagaattgt gccggtaaaa gacggcaagt ggcttccgtt tgtgccagga aagacttgga 698341 tcaatatcgt acctgatctt gatgcggctt ccattagtaa aggagaaggt gtgtaacgat 698401 gcaaatcgat aaattacgcg gcaaagagct ggaccagtta tttaactcga tcttatcgct 698461 gaaagacctg gaggaatgtt accgattctt cgatgatcta tgcacaatta acgaaattca 698521 atcgctggct cagcgccttg aagtggcgcg catgcttcgc gaaggaaaca cgtatcataa 698581 gattgaaaca gaaacaggcg cttccacggc tacgatttcc cgtgtgaaac gctgcttaaa 698641 ttacggaaat gacgcttatg aaatggcgct tgaccgtgtg aaggagacgg aaacagagtc 698701 ttcttccaaa taaaaaaccg ccctgccgtc tggcaagggc ggtttcttta tgaaacaaat 698761 tgatggatca ggttgtcgat attgatgata ctgccatcct ctttccgata gacaacatgc 698821 tccttggaaa aatgaatcgg cgaattaatc cctgctgcgg ctgcaaggtt aaatagtccc 698881 tcgcgcaatg aaataacgta gttgcagaca cgatgctgtt tttcctcaac gctcagtgct 698941 ttttgcaatt tcggatctgt cgtcgccaca cctgccggac aggtgttggt gtggcagacg 699001 agagcgcgga tgcagccaac ggaaaacatc atgccgcgtg cgatgttaac aaagtcagcg 699061 ccgagggcta aggcgaccgc gattttatca ggagtcagga gctttccgga agcaaagatt 699121 ttcagctggc tgcgcaagcc gtactgttta agaagcgtgt ccacaatagg cagcgctgtc 699181 ataatcggaa ggccgactgt atccgcgagc tcgtaaaagg aagctccggt accgccttca 699241 cttccgtcga tcgtgataaa atccggatgc tttccgcttt tctgcatatg agagaaaagc 699301 tcatgcaatt cttcaggatg ccctgcgacc agtttgatgc cgactggctt ttgtccgaca 699361 tctctaagtt tttcaataaa gtcgagcatt tcaggagggt ttgagaattc ataaaagcgg 699421 ttcgggctgt caatcgactt tccaggttcg acattccgaa tgtctgccac ttcctctgat 699481 actttggcgc cgtccacatg gccgccgcgg gttttcgctc cttgtgccag ctttagctca 699541 aacgctttaa tctggtcaat cctgcttttt cttttaaatt cctcccacga aaattccccg 699601 tttcttttgc gcacgccgaa taggcccggt ccgatttggc aaatgatatc ggcgccgccc 699661 tttaagtgat attcagacaa tcccccttca cctgtattca tccaggtgcc gcctgccaga 699721 tggagccctt ttgagagcgc cgtaacagcc cgttctccaa gagaaccgta gctcatggca 699781 gactggccga ctaagccctt cacataaaat ggcttctcgc atgtatgctc gccaatcacc 699841 tgtacatcat caggatggag aaaatacggg tctgccttga tatgttcggc atgctccttg 699901 cgtttgaaca gattgtcagc atccatttta tagatttggg tttcaatttt tggcgtttga 699961 tttacatgca tttcttccct ttgttttgga aacatagcgt tacggatata atagccaggt 700021 ttatcaaaat ctcttacaga tccaaagccc atcattctgc ttttgtattt gccggagatg 700081 acggtttgct catattcctt tcgtgaaaat ggctgctctt cattgtcatt gctgtataaa 700141 tactgtctga gctccggccc gattttttca aggatatacc gaaaccttcc gatgacggga 700201 tagttgcgaa gaattgagtg ctcctgctgt ttttcatcct ttatgtagat ccaggcaaac 700261 aagacgatcg ggatagcgat gatcccaatg ataaatgcga tgagtgctat tatgatggtt 700321 tccatctctc agcctccctt tttatgtaac catttccaca gtagaacact ttccaaacaa 700381 tagcagaagg aatctggtga aaaatgtgtg ctcctgccga tacaggactc accatgcagg 700441 tactgccata tgctctcttt ttttatgaaa aaagaatcaa aacacctttt tcagtgaata 700501 acgagattaa cggctttttc cgtttttccg cgctatgtga atttgttata atgtttaaat 700561 ggtaacaaac gaatggagga acgtatgacg tgtacgatgt aacggagtgg aagcatgtct 700621 ttaaactcga tccaaataaa gatttgcctg acgaacagct ggagattctt tgcgaatcag 700681 gaacggatgc ggtcattatc ggaggaagcg atggtgtgac agaggataat gtcctgcgga 700741 tgatgtctaa ggtaagacgg tttttggtgc cgtgtgtcct agaggtatca gcgattgaag 700801 cgattgttcc cggctttgac ttatatttta ttccgagtgt attaaacagc aaaaacgcgg 700861 attggattgt cggaatgcac cagaaagcca tgaaggaata cggagaactg atgtctatgg 700921 aagaaatcgt ggcggagggc tactgcatcg caaatccaga ttgcaaagcc gcggcactga 700981 ctgaagcgga cgccgatctg aatatggatg atattgtcgc ctatgcgcgt gtgtcggagc 701041 tgctgcaact gccgattttt tatttagaat acagcggcgt gcttggagac atagaagctg 701101 tcaagaaaac gaaggctgta ttggaaacgt ccaccttgtt ttacggcggc ggcatcaagg 701161 atgcggaaac ggccaagcag tacgcagagc atgcggacgt gatcgttgta ggcaatgcgg 701221 tgtatgaaga ttttgacagg gctttgaaaa cagtagcggc tgtgaaaggc gagtagtaaa 701281 ttgtacggat ttggtttatg atagaacgta tgttttgtat aggcgggtga acaaattttg 701341 aattatatta gcaatcaatt actaagcggt ttaaaccccg ttcagcagga agcagtcaaa 701401 acaacggacg ggcctctttt gctgatggcg ggagcgggta gcggaaagac gcgtgtcctg 701461 acccatagaa ttgcttattt aatggcagaa aagcatgtgg cgccgtggaa cattctggcg 701521 atcacattta caaataaagc ggcacgcgaa atgaaagaac gtgtggaaag catcctcgga 701581 cccggcgcgg acgatatctg gatctccaca ttccacagca tgtgcgtgcg gatcttgcgc 701641 agagatatcg accggattgg gatcaaccga aatttctcca tccttgatac ggctgaccag 701701 ctttcagtga tcaaggggat tttgaaggag cgcaatcttg atccgaagaa gtttgacccg 701761 agaagcatcc tcggcacgat cagcagtgca aaaaacgaat tgaccgaacc ggaggaattc 701821 tctaaagttg ctggcggcta ctacgatcag gtggtcagcg atgtatatgc tgattatcag 701881 aagaagctat tgaaaaacca gtcgctcgat ttcgacgatt taattatgac gacgattaaa 701941 ctgtttgaca gagtgcctga agtgcttgaa ttttatcagc gcaaattcca gtacatccac 702001 gttgatgagt atcaggatac gaacagggca caatacatgc tcgttaagca gcttgccgag 702061 cgtttccaga acctttgcgt tgtgggggat tctgatcagt caatctacag atggcgcggc 702121 gcggatatca ccaacattct ttcatttgaa aaagattatc cgaatgcaag cgtgattttg 702181 ctagaacaaa actatcgttc aacgaaacgg attttgcgcg cggctaacga ggtcattaaa 702241 aacaactcta accgcaaacc gaaaaatttg tggacggaaa atgatgaagg catcaagatt 702301 tcctattatc gcggtgataa tgagttcggt gaaggacagt ttgtggccgg caaaattcat 702361 cagcttcaca gcacaggcaa gcggaagctg tcggatatcg ccatattata ccggacaaac 702421 gcgcagtccc gtgtgattga ggaaacgctt ctcaaagcgg gcttgaacta taacattgtc 702481 ggcggcacaa agttctatga cagaaaagaa attaaagaca ttcttgcgta cctgcgcctc 702541 gtatccaatc cggatgacga tatcagtttc acgcgcattg tcaatgtgcc gaagcgcgga 702601 gtcggcgcga catcacttga aaaaatcgct tcgtatgcgg ccataaacgg cttgtccttt 702661 ttccaagcga ttcagcaggt tgattttatc ggcgtcagtg ccaaagcggc aaacgcgctt 702721 gacagcttta gacagatgat tgaaaacctg accaatatgc aggattactt atccattaca 702781 gagctgacag aagaaattct tgataagacg gaatacagag aaatgctgaa ggctgagaaa 702841 tcgatcgaag cccaaagccg tttagaaaat atcgacgagt tcctgtctgt tacgaaaaac 702901 tttgaacaga aaagtgaaga caagacactc gttgcgttcc tgacagactt ggcattgatc 702961 gcagatattg atcagctcga tcagaaggag gaagagtcag gcggcaagga tgcgatcacc 703021 ctgatgacac tgcacgccgc gaaaggactg gagtttccgg ttgttttctt gatggggctt 703081 gaagaaggcg tcttcccgca tagccgttca ctcatggagg aagcggaaat ggaagaagaa 703141 cgccgccttg cgtacgttgg gattacaagg gcggaacagg agctttatct gaccaatgct 703201 aaaatgcgca ccttgtttgg ccggacaaat atgaacccgg aatctcgctt cattgctgaa 703261 ataccggatg atttattgga aaacctaaat gagaaaaaag aaacaagagc gacgtctgcg 703321 agaaaaatgc agccgagacg cggccctgtt tcacgcccgg tatcctacgc cagcaaaaca 703381 ggcggcgaca ccttgaactg ggcagtcgga gataaggcgg gccataaaaa atggggaaca 703441 ggaactgtcg tcagcgtgaa aggcgaagga gaagggacag agcttgatat tgccttcccg 703501 agccctgtcg gcgtgaaacg cctgttagca gcatttgctc ctattgaaaa gcagtaattg 703561 aagaggaaag gaagaagcag atggacaaag aaacagcgaa gcagcgggca gaagaactgc 703621 gccgcaccat caacaagtat agctatgaat attacacctt agatgaaccg agcgtcccag 703681 atgccgaata cgacagattg atgcaggagc tgatcgcgat cgaggaggag cacccagacc 703741 tcagaacgcc tgactctcct acgcagcgcg tcggcggagc cgtgcttgaa gcgtttcaga 703801 aagtcaccca cggcacaccg atgctcagtc tgggcaacgc ctttaatgct gatgatcttc 703861 gtgatttcga ccgccgtgtg cgccagtccg tcggcgacga tgtggcgtat aatgtggagc 703921 tgaaaataga cggtcttgct gtttctctcc gttatgaaga cggctatttt gtcagagggg 703981 ccacaagagg tgacgggacg acgggagagg atatcacgga gaatctgaag acgatccgca 704041 atatccccct taaaatgaac cgtgagctgt cgatcgaagt gcgcggcgag gcgtatatgc 704101 cgaagcgttc gtttgaagca ctcaatgagg aacggattaa aaatgaggaa gaaccgttcg 704161 ccaatccgcg aaatgccgcg gcgggatctc tcagacagct cgatccgaaa attgcagcga 704221 aacgaaacct cgatatcttc gtctacagta tagcggagct tgacgagatg ggtgtagaga 704281 cgcaaagcca agggcttgat tttctcgacg aactcggatt taaaacgaat caggaacgaa 704341 aaaaatgcgg cagcatagaa gaagtcatta cgctgatcga tgagcttcag gcgaagcgcg 704401 cggacctgcc gtacgaaata gacggcattg tcattaaagt cgattctctc gatcaacagg 704461 aggagctcgg ttttacggcg aaaagcccgc gctgggccat cgcgtataag tttcctgctg 704521 aagaggtcgt gacgaagctt ctcgatatcg aattaaatgt cggcagaacg ggtgtgatta 704581 cgccgactgc gattcttgag ccggtaaaag ttgccggcac aacggtctca agagcatccc 704641 ttcataacga agatttaatt aaagagaagg acattcggat tttggataag gttgtcgtca 704701 aaaaagcggg cgatatcatc ccggaagttg tgaatgtcct cgttgaccag cgcacaggag 704761 aagaaaagga attcagcatg ccgacggaat gtcctgaatg cggcagtgaa ctcgtccgga 704821 tcgaaggaga agtggcgctt cgctgcatta accctgaatg tccggcgcaa atccgggaag 704881 ggcttatcca tttcgtttcc cggaatgcca tgaacattga tgggctcggc gaacgagtga 704941 tcacacagct gtttgaggaa aaccttgtcc gcaatgtggc agatttatat aagctgacga 705001 aggaacgagt catccagctc gagcgcatgg gcgaaaagtc cactgaaaac ctgatcagct 705061 ccatccaaaa atcaaaagaa aattcgttag agcgcctgct gtttgggctt ggcatccgtt 705121 ttatcggatc aaaggccgca aagacgcttg ccatgcattt tgaaagcttg gagaacctga 705181 aaaaagcctc taaagaggaa cttctcgcgg tagatgaaat cggtgaaaaa atggctgatg 705241 ctgtgatcac ctattttcat aaagaagaaa tgcttgaact cttgaatgaa cttcaggagc 705301 tgggcgtaaa cacgctctac aaaggcccga aaaaagtaaa agcagaggac agcgactctt 705361 actttgctgg taaaacaatt gttctgacag gaaagctgga agagctgtca agaaacgaag 705421 ccaaagcgca aatcgaagcg ctgggcggaa agctgactgg aagcgtcagc aaaaacacag 705481 acttagtcat cgccggagaa gcggcgggaa gcaagctgac aaaagcacaa gagctgaaca 705541 ttgaagtgtg gaatgaagaa cagttaatgg gagagctaaa gaaataagag gagtgttttc 705601 tattgaaaaa gacgttggca ttggcggcaa cggcggcagt attaatgctg tctgcctgct 705661 cgtcaggttt cgggggggag aaggaggaag agattacgca aaagacggcg aaatcgtcag 705721 aaaaagcgat tgtcccgaaa tataatatct ctgactccta ttacaaaatg gtgctgccgt 705781 ttaaggcagg caaagcgcgc ggcttaacaa cggaacagct gaatacaagg ctggacattg 705841 acgaatttga aacagggctg atgcgccttg cccaagattc tttctcaact gacgattatc 705901 tgttccaaga aggacaatat ttagatgagg atacagtatt aagctggctg gcacggaaaa 705961 aaacgggctc tgatttgaaa aaagccgaaa aagaagataa gaacttcaaa aatgaaggct 706021 tgaacccggc gctcccgagt tctggttcaa cagaagaaaa gaacgaaagc agcccaattt 706081 atttagcatc catgcttgag cacgattatt tagtcagaaa agacaagaat tctatccagc 706141 ttggcggcgt catgatcgga ctggcgttaa actcagtgta ttactatcgt gaaaaaactg 706201 gcgacccgca aaaagaagtg gagattaaag acagcacgct tcgccagcag ggagaaaaaa 706261 ttgcacagga ggttattaac cgcctccgca aaaaagataa cttgaagaat gtgccgatta 706321 ccgtggcgct ctacaagcag gcgtcaaaaa catcgattgt gccggggaac ttcatcgcca 706381 aaacagaggt caaagcaggc tctactgata tctcaaattg ggatgacatc aatgaaaaat 706441 atgtattcta tccggcggat acaaccacag cagaaaagta cccggatgac accgaggtct 706501 ttaagcggtt caaaaactca attgaagaat atttcccgaa ctatacaggc gttgtcggta 706561 cagcgctgta tgaaaatgat gaaatgaaga aaatgaagat tgacatacca atgcaattct 706621 acggaaaaag tgaagttgtc gcgtttaccc agttcttaac gggtgaagtg atggactact 706681 actctaagag ctcagttgat gtcgaagtca atatcacgtc ctcagacgga caggaagcgg 706741 tcattatccg caatgccgga gataaagagc cgactgttca catttatgac tgatagaaaa 706801 cccttgtgcc atattggcac aagggttttt atgttacaat taacaggaaa agggaaaata 706861 ttttcacttc tgccgaaaca caaatcaagg ggaggtatgt tgatgctgga aatcgtgtga 706921 aaacaatcat tatcaaatct atagcaatga aaggatgtta gacgtgcata aagatatcaa 706981 aaaaatattt catgaagagc aggttttggc agaagctgca gcgagatacg gtttctcaaa 707041 agatcaggtg cgttttctgg ctgatgcgga aaactatgta tatgaatgta tgaaagacaa 707101 tcaaccttat attttaaaga ttacccatac gattcggaga tcttctgatt atatgatggg 707161 agagatggaa tggctccgtc accttgcaat agggggaatt tcagtagcca aaccgctccc 707221 gtcgctgaac ggaaaagacg tagaagcagt gccggacgga aacggcgggt catttttatt 707281 gagagtgtat gagaaagcgc cggggcaaaa agtggatgaa tcggactgga atgaaacgct 707341 attttatgag cttggcagat acacaggcag catgcacagc ctgacaaaaa gctacaaatt 707401 gagcaatccc gctttcaaaa gacaggaatg ggatgaagag gagcaattaa agctgagaaa 707461 atatgtgcct gaagatcaga taaaggtgtt tcagcaagcc gattctttga tgaatgaact 707521 gcggaggctc ccgaaaagcc aggacaacta cggcttggtg catgcggatc tgcaccatgg 707581 caattttaac tgggatcatg gcaaaatcac ggcatttgat tttgatgata tcggctacaa 707641 ctggtttgtt aacgatatta gcattcttct ctacaatgtc ctgtggtatc ctgttgtgcc 707701 atatgatgat aaagctgcgt ttacagaaga atttatgacg cattttatga aagggtactg 707761 ggaggaaaat gagcttgacc ctgcatggct gatgataata cctgatttcc tccgccttcg 707821 ccatatgctg atttacggat tgctgcatca gatgtttgac cttaacacaa taggagaaga 707881 ggaaaaagaa atgctggccg gtttcagaag agatatagag aatggcacgc cgattacagc 707941 atttgatttt tcagcactgg tgtagataga aaaagccaat gggattccag tcccattggc 708001 ttttataatg tatcacactt cacgccgact acgccttcaa tggctttaat gtcatagtag 708061 acatcggtcg tgtatctgtt tttatggacg cggaccttca cttccataat tggaaaatcc 708121 ttttcgccta ggtcgtcgat ccgaacggag tgtgctttga tatctcttct tttcatttct 708181 tttaaaatct ctgtcatttt gtctttatca gaaagtgaca ttctgatgcg gatgtctttt 708241 tcctgcaggc ggtcggggcc gatttttctg accacccatg ggagaaattc cacactgatc 708301 aggatgaaca gaagactggc aaacgcttct ttataaaaac cggctcccgt agcaagcccg 708361 agccccgctg ccccccagat catggccgat gtcgtcaggc cggaaatgac atcattgctt 708421 tttcgcagga tgacaccggc gccgataaac ccgacgccgg agatgatttg tgccggcaga 708481 cgaagcggat ccatcatgat gcggtagtat ttagggaaat gatatgccgc attaatactg 708541 acgatcgtca gcatgcatga gctgactgcg atgacaatac aggtttttaa tccgagcggc 708601 ttatttttta attcgcgttc aagcccgatg accatgccaa tcaatgtggc aatgcccaat 708661 ttcaataaaa tatcaggatc aatataccag ctcaacagca aacttccccc ttctctatgg 708721 tgtttttaaa taaatatgat tttctcacag tatttatagc aaaacaagag cacaaaagcc 708781 accaagctgc gcttgatggc ttattgctta ctttttgcgt tttaacagct tttccatgac 708841 accgaataat cggtaagagg cttttgcagg acgttttgtg atcatgctga caatgatgcc 708901 ggcaatcata ctgagaataa acccagggat gatttcgtac acaccggttg attttgccag 708961 gccggttgta atccagatca acacggtcgc agccccgaca atcatggcag caagcgcgcc 709021 ccattcgttc attcgtttcc aatacagact gagcagaatc gcaggcccga aagctgaacc 709081 gaagccggcc caagcgtatc cgaccaaatc aagaatggtg ctgttcgggt tcaatgacaa 709141 gagtaccgcg ataacggcaa tgactaagac ggacaatcgc ccgatcatga ccaattcttt 709201 atcagaagct tttcgtctga aaaatgaccg gtataaatcc tctgttacag cacttgctgt 709261 gaccaagagc tgtgaggaaa tcgaactcat gatggcagcc aaaatagctg acaataagaa 709321 ccctgtaatt aatgggtgga acaagatttt agagaagata atgaaaatca tctccggatc 709381 ttttacagca actccgaatt tatgggcgta tgcaacaccg attaaacccg tcagcacgga 709441 acctagaact gtaatgatca tccagctcat gccgattcgg cgtgcaggtt ttaaatcttt 709501 aatgtcttta atggccataa atcggacgat gatatgaggc tggccgtagt agcccaaccc 709561 ccaggctaaa taggaaataa tgctaatgac gctcgcgcct ttaaaaatat ccaataaatg 709621 tggattaaca gcgtcgattt catggaaagt cggagcaacg ccgcccacat gggtaaaagc 709681 aacgatcggc acaagcacta gtgctgcaaa catgatcgca ccctgcacga agtcagtcag 709741 actgacagca aggaaaccgc caaacagtgt gtataacacg acaactgcgg tggtcagaaa 709801 caggcctaat ttgtaatccg caccaaaagc agattcaaac agccgtccgc cagataccat 709861 accggaagag gtatacaatg tgaaaaagat catgatgatc aatgcagata cgattttcag 709921 cagtgatgaa gaatgctgga atcgtttatc aaagaaatca ggaattgtaa tcgcatcatc 709981 tgccgcttct gtataagcac gcagccttgg agccagcagc aagtaatttg agtacgcccc 710041 gattgtaaga cctaaagcaa gccataaggt ggacagccct gtcgcaaaca tcgcgccggg 710101 aacacccatc agcatccatc cgctcatatc ggccgcgccg gcagacaaag cagtaacgaa 710161 tggtccgagg cctcttcctc caagcatgta atcattgatg tcagtggttt tcttgaatgc 710221 ataccagccg attaacagca tggcaataaa gtaaattcct aaagatataa taatttcaat 710281 actcacgttt taccctctct tcatttctaa taatgttgca tcacctctca aattgatggt 710341 gccagttaag cagcctggcg taagtgcaaa acaaaagaaa ttcttttgcg ggtgcacttg 710401 gtaacttaac ctaacaaagt attcccggcc attcaagcga tgaaacattg atcataagct 710461 ggaaataccg ttgcaaacct agaagggaat aaagaataaa acgctttcaa aaaataatta 710521 aagtaaaaat attcagaaaa atatttcgtt tctccttctc ctcattttag tataaaatat 710581 atagggtatt gtttcgaaaa cacaggcctg tctcaaggcg ttttgttgct ttaaagggct 710641 tgtttttgat atgatcagta ttatatgact taacggagaa atatgtggag gtggatcata 710701 tgtcacgaat ttcaatagaa gaagtaaagc acgttgcgca ccttgcaaga cttgcgatta 710761 ctgaagaaga agcaaaaatg ttcactgaac agctcgacag tatcatttca tttgccgagg 710821 agcttaatga ggttaacaca gacaatgtgg agcctacaac tcacgtgctg aaaatgaaaa 710881 atgtcatgag agaagatgaa gcgggtaaag gtcttccggt tgaggatgtc atgaaaaatg 710941 cgcctgacca taaagacggc tatattcgtg tgccatcaat tctggactaa aggagggaca 711001 caagaatgtc attatttgat cataaaatca cagaattaaa acagctcata cataaaaaag 711061 agattaagat ttctgatctg gttgatgaat cttataaacg catccaagcg gttgatgata 711121 aggtacaagc ctttttggca ttagatgaag aaagagcgcg cgcatacgcg aaggagcttg 711181 atgaggcggt tgacggccgt tctgagcacg gtcttctttt cggtatgccg atcggcgtaa 711241 aagataatat cgtaacaaaa gggctgcgca caacatgctc cagcaaaatt ctcgaaaact 711301 ttgatccgat ttacgatgct actgtcgttc agcgccttca agacgctgaa gcggtcacaa 711361 tcggaaaact gaacatggac gaattcgcca tggggtcatc tacagaaaac tcagcttaca 711421 agctgacgaa aaacccttgg aacctggata cagttcccgg cggttcaagc ggcggatctg 711481 cagctgcggt tgctgcggga gaagttccgt tttctcttgg atctgacaca ggcggctcca 711541 tccgtcagcc ggcatctttc tgcggcgttg tcggattaaa acctacatac ggacgtgtat 711601 ctcgttacgg cctggtcgca tttgcgtctt cattggacca aatcggaccg attacacgta 711661 cggttgagga taacgcgttt ttacttcaag cgatttccgg cgtagacaaa atggactcta 711721 cgagtgcaaa tgtggacgtg cctgattttc tttcttcatt aactggcgac atcaaaggac 711781 tgaaaatcgc cgttccgaaa gaataccttg gtgaaggtgt cggcaaagaa gcgagagaat 711841 ctgtcttggc agcgctgaaa gtccttgaag gtctcggcgc tacatgggaa gaagtgtctc 711901 ttccgcacag taaatacgcg cttgcgacat attacctgct gtcatcttct gaagcgtcag 711961 cgaaccttgc acgctttgac ggcatccgct acggctaccg cacagacaac gcggataacc 712021 tgatcgacct ttacaagcaa acgcgcgctg aaggtttcgg aaatgaagtc aaacgccgca 712081 tcatgctcgg aacgtttgct ttaagctcag gctactacga tgcgtactac aaaaaagcgc 712141 aaaaagtgcg tacgttgatt aagaaggatt tcgaggacgt atttgaaaaa tatgatgtta 712201 ttgttggacc gactacaccg acacctgcgt ttaaaatcgg tgaaaacacg aaggatccgc 712261 tcacaatgta cgcaaacgat atcttaacga ttccggtcaa ccttgccggc gtaccgggaa 712321 tcagtgtgcc atgcggatta gcagacggac ttccgctcgg cctgcaaatc atcggaaaac 712381 actttgatga aagcactgta taccgcgttg ctcatgcatt tgaacaagca acagaccatc 712441 ataaagcaaa acctgaactg taaggggtga aaagaattga actttgaaac ggtaatcgga 712501 cttgaagtcc acgttgagtt aaaaacaaaa tcaaaaattt tctcaagctc tccaacgcca 712561 ttcggcgcgg aggcgaatac gcagacaagc gttattgacc tcggatatcc gggcgtcctg 712621 cctgttctga acaaagaagc cgttgaattc gcaatgaaag ccgctatggc gctcaactgt 712681 gagatcgcaa cggatacgaa gtttgaccgc aaaaactatt tctatcctga caacccgaaa 712741 gcgtatcaga tttctcaatt tgataagcca atcggcgaaa acggctggat cgaaattgaa 712801 gtcggcggca aaacaaaacg catcggcatc acgcgccttc atcttgaaga ggatgccgga 712861 aaactgacgc atacgggcga cggctattct cttgttgact tcaaccgtca aggaacgccg 712921 cttgttgaga tcgtatcaga gccggacatc cgcacgccgg aagaagcgta cgcatatctt 712981 gaaaagctga aatccatcat ccaatataca ggcgtttctg actgtaaaat ggaagaaggc 713041 tcacttcgct gtgacgccaa tatctctctt cgtccgatcg gccaagagga attcggcaca 713101 aaaacagaat tgaaaaactt gaactccttt gcgtttgttc aaaaaggcct tgagcatgaa 713161 gaaaaacgcc aggagcaggt tcttctttcc ggcggcgtca tccagcaaga aactcgccgt 713221 tatgatgaag caacgaagaa aaccattctt atgcgtgtca aagagggatc tgacgactac 713281 cgttacttcc cagagccaga tctagtcgag ctctacattg atgatgaatg gaaggaacgc 713341 gtaaaagcaa gcattcctga gcttccggat gagcgccgca agcgttatat cgaagagctt 713401 ggcttgcctg catatgacgc aatggttctg acgctgacaa aagaaatggc tgatttcttc 713461 gaagaaaccg ttcaaaaagg cgctgaagct aaacaagcgt ctaactggct gatgggtgaa 713521 gtgtcagctt acctaaacgc agaacaaaaa gagcttgccg atgttgccct gacacctgaa 713581 ggccttgccg gcatgatcaa attgattgaa aaaggaacca tttcttctaa gatcgcgaag 713641 aaagtgttta aagaattgat tgaaaaaggc ggcgacgctg agaagattgt gaaagagaaa 713701 ggccttgttc agatttctga cgaaggcgtg cttctgaagc ttgtcactga ggcgcttgac 713761 aacaatcctc aatcaatcga agactttaaa aacggaaaag accgcgcgat cggcttccta 713821 gtcggacaga ttatgaaagc gtccaaagga caagccaacc cgccgatggt caacaaaatt 713881 ctgcttgaag aaattaaaaa acgctaataa aaaagcagcc cttagaggct gcttttttta 713941 tggtcaaatt gagataaaga caagatgagg gcccgaagcc tttcaacttc tttgtcgttg 714001 gttccggcca aattggacag catgccttta ataatcggct tgcgcggttt atcctgagtc 714061 aattcttcct cgataacatc aagtgacacg gtgatatcct cgggcagcgt gctgttttct 714121 ttcactttct gaatgtcctc aagcagctgg tcttttcccg caggcatcgg gttaaaaatg 714181 tcttttgata caatcggatt gagtgcagaa cggctcagcc cctgtacaag atcatccagt 714241 ctctcaataa taaaggctga gatttcttct gcatcgatat taagctcacc gttaaatacc 714301 atcacgttca tataggaatg cacaatgcct cttgccatga tggacagatc tgcgacatac 714361 cgctcgattc cttcgccata ggataccagc aaggcgttcc ggtacagctt atccgtctcc 714421 atggttactt tgtaaaagta ttgcttgatt tcttgatttt ccggaatgat attttcggta 714481 agcaaaagaa cgataaaatc tttatgatcg cgaaaatcct caaattgagc gccaatttgc 714541 ttttttaaca cttccttagg cggctttccg gcgagatctt cttctatatt tttcattttg 714601 ttcatagaca taccgatata atattcacag gcagataaca gcagcgcttc tttcgatttg 714661 aagtgcaaat aaaaagcgcc cttcgaaatg ccgcattcac tggcgatttc ttggatcgtc 714721 gtagctgcga atcctttttt cgcaaataaa cgaatgctgg tttttatgat tctctctttt 714781 ttttcattca tgacgtgctt ccccttaatc cttgaaaaat ttagtaaaat tttctggtat 714841 atgagttgac gttgttgcgt tataacgttt agtattatat agaatgacca gtcagtcaat 714901 aaaaaatgta atggaggata tgatgaacca cgttattaat ttcgttctga aaaacaaatt 714961 cgccgtatgg ctgatgacga ttattgtaac ggcagccggc ttgtatgcgg gtatgaatat 715021 gaagcaagag tctattcctg acgtgaacat gccttacttg acgatcagca cgacatatcc 715081 gggtgcaaca ccaagccaag tggctgatga agtgaccaaa ccggttgaac aagccgtaca 715141 gaacttggac ggtgtcagcg ttgtgacgtc gacgtcctat gaaaacgcat cgtcggtcat 715201 gattgaatat gattatgaga aagatatgga caaagcgaaa acagaagcag ctgaagcgtt 715261 agaaaacgtc aacctgcctg atgacgcgaa ggatccggag atttcacgct acagcttgaa 715321 ctcattcccg attctgacgc tgagcgtgtc cagtgataaa gataatctgc aagagctgac 715381 gaaacaagtg gaggacagcc tcgtttctaa gcttgaaggc atagaaggcg ttgcgtccgt 715441 ccaagtatca ggccagcagg tggaagaggt tgaattctct ttcaaagaag acaaactgaa 715501 ggaatacggc cttgatgaag atacagtcaa gcaagtgatt caaggttcag atgtgacaac 715561 tccgcttgga ttgtacacat tcggaaatga agaaaaatct gtcgtcgtca gcggcgatat 715621 tgaaacaatt aaagatttga agaatatgag aatcccgacg gcatctgctt caagtgcagg 715681 cagcagcgca gcatctcaag caggtgcgca gagtgctcaa gcagcccaaa gcgcgcaagc 715741 ggcagcacag gtgcagcaaa gcgcaagcac agcagtgccg acggtcaagc tttctgacat 715801 tgctacaatt aaagatgtga aaaaagctga atccgtttca cgcacaaatg gcaaagacag 715861 catcggcatc aacatcgtca aagcaaacga tgcgaatacg gtagaggttg ccgacgatgt 715921 caaagctgag ctgaaaaagt tcaaagaaga ccataaaggc ttcaattaca gcgcaactct 715981 cgacatggcg gagccgatca cacagtcagt tgacacgatg ttaagcaaag ccatcttcgg 716041 tgctattttt gcgattgtga ttattctctt attcttaaga gatatcaaat caacattaat 716101 ttctgttgtt tcaattccat tatcattgct gatcgcactc cttgtgctgc agcagcttga 716161 tatcacattg aatattatga cgctcggcgc aatgaccgtt gccatcggac gtgtagtcga 716221 tgactccatc gttgtgatcg agaacattta ccgccgcatg agactcaaag atgagccgct 716281 ccgcggaaaa gccttggttc gtgaagcgac gaaggaaatg tttaaaccga tcatgtcatc 716341 aacgattgtg acaatcgcgg tattcctgcc gctcgcactt gtaggcggac aaatcggtga 716401 attgtttatt ccatttgcct taacgattgt ttttgcgctt gccgcatccc tagtgatttc 716461 aatcacgctt gtgccgatgc tcgcacacag cctgttcaaa aaatcattaa ccggtgcgcc 716521 gattaaagcg aaagaacaca aacctggcag acttgcaaac atctataaaa aagtattgaa 716581 ctgggcgctg agccacaaat ggatcacgtc tatcatcgcg gttctgatgc tccttggaag 716641 cttgttcctc gtaccgttaa tcggtgccag ctacctgccg tccgaggaag aaaaaacgat 716701 gcagctcaca tacagcccag aaccgggtga aacgaaaaaa gaagccgaaa atgaagctga 716761 aaaagcggaa aaaatcctgc ttgaccgcaa gcatgtcgat acggttcagt attcattagg 716821 ctctggcagc ccgcttgccg gaggagattc taacggtgcg ttattctata tcaaatatga 716881 aagcgacaca cctgactttg ataaagaaaa agataacgtt ctgaaggaaa tccaaaagca 716941 atctgaccgc ggagaatgga agtcacagga cttcagctct tcaggcaata ataacgaatt 717001 aacatactat gtgtatggcg attctgaaaa cgatattaaa gacacggtca aagacattga 717061 aaaaatcatg aaagatgaaa aggatctgaa aaacgtaaat tcaggccttt ccagcacata 717121 tgatgagtac acatttgtcg ctgaccaaga aaaactaagc aagctcggtt taaccgcgtc 717181 tcaaatttct caggccttaa tgtcacaaac atcgcaagaa ccgctcacca ctgtgaaaaa 717241 agacggcaaa gagcttgatg tgaacattaa gacagaaaaa gacgagtata agagtgtgaa 717301 agatttagag aataaaaaga tcacttccgc gactggccag gaagtcaaaa tcggcgatgt 717361 ggcaaaagtg aaagaaggat caacatcaga taccgtgtca aaacgtgacg gaaaagtcta 717421 tgcagatgtc acaggtgagg ttacctctga caacgtcaca gccgtatcag ctgctatcca 717481 gaagaaaatc gataagcttg accaccctga taacgtatcg attgacacag gcggcgtatc 717541 agcggatatc gctgattcct tcacgaagct cggtttagcg atgctggcag caatagcgat 717601 cgtttacctt gtgctcgtga ttaccttcgg cggagcacta gcgccatttg cgattctgtt 717661 ctcattgccg ttcacagtca tcggtgccct ggtcggactt tacgtatcag gtgaaacgat 717721 cagtctgaac gccatgatcg gtatgctcat gctgatcggt atcgttgtca cgaatgccat 717781 tgtcttaatt gaccgcgtga ttcataagga agcggaaggc ctgtctacga gagaagcgct 717841 cctggaagcc ggctctacac gactccgtcc gatcctgatg acagccattg cgacaatcgg 717901 cgccttgatt ccattagccc tcggcttcga aggcggaagc caggtcattt caaaaggact 717961 cggcgtaacg gttatcggcg gtttaatcag ttcaacgctt ctgacgctcc tgatcgtgcc 718021 aatcgtatat gaagtattgg cgaagttccg caagaaaaaa ccgggaacgg aagaagagta 718081 aaaaacaaaa agcctcagct ctgctgaggc tttcagcttg ttgaaaaacc ctcgcattcg 718141 ttgtcaggtc tgcgcgtcgg tgctcacgaa ttctacattc gctccgctcc aatgctcccc 718201 cttcctagac tacaagggtt ttcaatcaag ctgaaagaat gttaaggatg acaaaagctc 718261 aaaacaagaa tcagttttga gcttttgtgc gttttcacct gtaagattat gtacattttg 718321 ttgcgatttt tttaactcat agtataatta aaggttgtta gtgtaaaaat ggatcggata 718381 ctcttaagta ggatgatgag ataatgaaac gtgcacgcat aatatacaat ccgacttcag 718441 gacgggagat ctttaaaaag catcttgccc aggtcctgca aaaatttgaa caagccggct 718501 atgaaacctc cacccatgcg acgacatgcg caggagacgc tacacacgct gccaaggaag 718561 cggcattgcg tgagtttgac ctgatcattg cggcaggcgg agacggaacg atcaacgagg 718621 tcgtcaacgg gcttgcgcct ttagacaatc gtccgacact cggtgtgatt cctgtcggca 718681 caacgaacga cttcgccaga gcgctcggaa tcccacgcga ggatatttta aaagcggcag 718741 atacggtcat taacggcgtt gcccgcccga ttgatatcgg acaggtcaac ggccagtatt 718801 ttatcaatat cgccggcgga ggccgtctga cggagctgac gtacgacgtg ccaagcaaac 718861 tgaaaacaat gctcggccag cttgcttatt atttaaaagg aatggaaatg ctgccttcac 718921 ttcgtccgac agaagtcgag attgaatatg acggcaagct gtttcaaggt gaaatcatgc 718981 tgtttttggt cacgctgaca aactccgtcg gcgggttcga aaagctcgcg ccggattcca 719041 gcctgaatga cggcatgttt gatttgatga tactaaagaa agcaaacctt gctgaattta 719101 tcagggtcgc cacgatggcg cttcgcggag aacacatcaa cgaccagcac attatttata 719161 caaaagcgaa ccgcgtgaaa gtcaatgtat cagaaaagat gcagctgaac ctggacggcg 719221 agtacggcgg catgctgccg ggcgaattcg tgaatctgta ccggcacatt cacgtcgtca 719281 tgccgaagga gaaagcggaa cagttggatg actaaaactt ggcttggtaa gccaagctca 719341 gaatgttgac aaaatcctaa aacagttttc gttttaggat tttgtcatct tttcagcgtg 719401 attgaaaacc tttgaagtct aggaagggcg agcatcggag cacagcgaat gttgaattcg 719461 tgagcaccga agcacaggcc tgacaacgaa tgcgaaggtt tgcctacacg ctgaaacttg 719521 gcttgaatag gccaagtttt tctttcgctt aaaactagag gtgattatag atgaaaatga 719581 aacccccagt agaaaaaaat gaatactacg atgtgacatt tgaggatttg acacatgaag 719641 gagcgggcgt cgcaaaggtc caaggcttcc cgatctttgt gccgaatgcc ctacccgagg 719701 aaaaagccca aatcaaagtg acacgcgtca aaaaagggtt cgccttcggc cgcctgattg 719761 agctgaagga agaaagcccg catagaacgg acgccccatg cccgatttac aaacaatgcg 719821 gaggctgcca gcttcagcac atgacctacg aaggccagct cctgtttaaa cagaaacaag 719881 tcaaagacgt cttagaacgc atcggcaagc tggacctttc aaaagtcacc gtgcacccga 719941 cactcggcat ggaagacccg tggaactaca gaaacaaagc acaggtgccg gtaggagaac 720001 gggaaggcgg actcgtcgcg ggattctatc agcaaagaag ccatgacatc atcgacatga 720061 gcgcctgcct gatccagcaa tccaaaaacg acgaagccgt tcaagctgtc aaagacattt 720121 gcgcaaacta cggtgtcaaa gcctacaacg aagaacgcca caaaggctgg ctccgccaca 720181 tcatggtcag atacggcgtt gttacgggcg aaatgatgat cgtcttcatc acaagaacaa 720241 gcgacttccc gcacaaagcg aagatcatcg aagacatcac agcgcaattc ccgcacgtca 720301 aatccatcgt gcaaaacatc aacccaaaca aaacaaacgt catttttggc aacgaaacaa 720361 acgtcatctg gggcgaagaa tacatctacg acctcatcgg agacgtcaaa ttcgccatct 720421 ccgccagatc gttttatcag gtcaacccag agcaaacaaa agtgctctac gacaaagcgc 720481 ttgagtacgc tgagcttcaa ggggaagaaa ccgtcatcga cgcttactgc ggcatcggaa 720541 cgatttctct cttcctggca aagcaggcga aaaaagtgta cggtgtagag attgtgccgg 720601 aagcaattga ggacgcgaag cgaaacgccg aattaaacgg caacacaaac gcagagtttg 720661 ctgttggaga agcggaaacc gtgattccaa agtggtacga agaaggcatt acagctgata 720721 cgctggtcgt cgacccgcca agaaaaggct gcgacgaagc cctcctgcgg acaattgtgg 720781 agatgaagcc gaagcgggta gtgtatgtgt cctgtaatcc tggcacgctt gcgagagatt 720841 tgcgggtgct tgaggatggc gggtacgtga cgcgcgaagt gcagcctgtg gatatgtttc 720901 cgcatacgaa tcatgtggag tgctgtgtgt tgataaaatt aaaagaataa atagtcaaaa 720961 atctatgctg atggaactgt tggttctcta aaacgataat tgatttcaat ggttccattt 721021 gcatgtactt ctatttcatc tactaacaaa tgaagcattt cgggggtaag tgtaccttcc 721081 ttcatgaatt tatctaagct ctttttaaaa tcaattattt ctttttcaat cttttgaaat 721141 tctaggtcct tagatagttg gtgaagggta gtttcaaaat ttgaaatatc ttcattggtg 721201 atatttatgg ctaattggta atcttcttta gatataacac cattagcaag agagataact 721261 aaattggatt tatctctctt tttatcgttt aatttttcat taatttcgat tatcttagat 721321 tcgatttttt ctttgtactt taacgctttt tcacttaatt ctttaaaata attttcctta 721381 ctgaatttca aatatatctt atttaggttg gttattactt tatcagttaa atctatttca 721441 cttacgtaat gatcactaca tgcttttaaa ccatgtttat tataacttcc acaaacataa 721501 ccttttcgat tctttttaaa atgcattgac ctcctgcaat ctttgcaaac cgcagtattt 721561 gtaaagagat gtacttcagc ttgaggtctc cttctttttc tagttattaa aatctcttgt 721621 acaataagaa agtcttctaa aggtatgatt ggttcgtggc ttttttcaat aattatttgg 721681 ttttctaggt taactgacct tcttctttta ctggtaacac tcggtctata ttctctacat 721741 tgttgtagtg tcccagtata gtgaggattt tcgagaattt ttcttattga agatccgtgc 721801 catttgtcag tagcgttctt tttgcgggca agctgcgagg gactagtgac cccttcgtta 721861 tacaatcccc ttgctattgc atcaaagcct tttccagcaa tatattctga aaagattcta 721921 atatttacta ttttctctgc gtttgctgaa tttgagagag atatgattgt agaacgaact 721981 caagaaggta aaatgttggc caagcagaat ccggatttcc gagaaggaag acccaaaaag 722041 ttcacaaagc agcaaatcaa tcatgcatta acattactag aaaatcattc gtataaacaa 722101 gttgaagata tgactgggat atcagtttct acacttgtaa gagctaaaaa gaagaaagct 722161 gctgaagcta taaatggata aatattgtga attaattatt caatatcttg agaaattttt 722221 ataaaagtaa tcaaaagttt aatgggggaa acgaaatggc gctcattgat ttagaagata 722281 aaattgctga aatagtgaat cgagaagatc attcagattt cttgtatgaa ttactcggtg 722341 tatatgatgt tccacgagct acaattacgc gcttgaaaaa aggaaatcaa aaccttacaa 722401 aacgggttgg tgaagtacac ttaaagaata aggtgtggtt taaggaggct aagaaaggaa 722461 agctctttga cgcccttatt gatatagaac aacaagttga atatctttca gctaagccac 722521 gatatttatt agttactgac tatgatggag tattagcgaa agatacaaaa acattagagg 722581 ctcttgatgt taaatttgaa gaacttcctc agtatttcga tttcttcctt gcttggaaag 722641 gtattgagaa agtagagttt gaaaaggaaa accccgctga tattaaagca gccgaacgtt 722701 ttgcacggat atatgatgta cttcgtaaag aaaacaatat tattgagact aatagagggt 722761 tagatttatt tcttattcgt ttactgtttt gttttttcgc agaagatact gacatcttca 722821 aacgaaatag ttttacgaat ttaattaaga ctttgactga agaagatggt tcaaatctaa 722881 ataaattatt tgctgattta tttatcgtgt tagataaaaa tgaacgagac gatgttccat 722941 cttatttaaa agagtttccg tatgtaaatg gccagttgtt tactgaacca catacagagt 723001 tggaattttc tgccaaatcc agaaagttaa ttattgagtg cggtgaatta ttaaactggg 723061 ctaaaatcaa tcctgatatc tttggttcaa tgattcaagc tgttgcttct gaagaaagcc 723121 gtagttattt aggtatgcac tacacaagtg tccccaatat aatgaaggtt attaaaccgc 723181 ttttcctaga taaacttaat cagtcttttt tagatgcata cgatgattat acaaaacttg 723241 aaaatcttct aacacgaatc ggcaaaatta aattctttga tcctgcatgt ggttcaggga 723301 actttttgat tattacctac aaagaattac ggcgtatgga aatcaatatt ataaaacgac 723361 ttcaagaact cttgggagag tatctttatg taccttcagt aactttatct caattttacg 723421 gaatagagat tgaagatttt gcacatgacg ttgcaaaatt atcactttgg attgctgaac 723481 atcaaatgaa tgaagaatta aaaaatgaag ttcataatgc agtacgccca acgttaccac 723541 ttcatacagc aggggatatt cgttgtgcaa atgctattag ggttgagtgg actgaggttt 723601 gtcccgcaca aggatctgaa gaagtatatg tttttggtaa tccaccgtat cttggttcaa 723661 aaaaacaaaa caaagaacat aaatctgata tgttatcaat ttttggaaaa gtcaagaatg 723721 gtaaaatgct tgattatatt tctgcttggt tttactttgg tgctaaatac gcttcaacta 723781 caaatgcaaa agttgccttt gtatcaacaa attcagttac tcaaggggaa caggtttcta 723841 tcttatggaa tgagttattc aagtttggaa ttcaaatcaa ttttgcctat aaatctttta 723901 aatgggcgaa taatgctaaa aataatgctg cggtaattgt tgtgattgta ggttttggcc 723961 cgttagatac caaagtaaac aagtatttat ttgttgatga aacgaaaaag ctagtttcta 724021 acattagtcc ctatttaact gatggtgaaa atattcttgt ttcttctagg acgaagccaa 724081 tttcagactt acccaaactg cattttggga acatgcctaa tgatggcgga ggattactct 724141 ttaccattac ggaatataca gacgcaatca ataagtatcc tgaattagtt ccctatttta 724201 aaaagtttat aggttcagta gagtttatta atggtggttt acggtattgt ttatggctta 724261 atgaagcaaa atatgaaaaa ataaagtcta atcctctaat acaagaaaga atctcaattt 724321 caaaaaatca cagggaaaaa tcaacagata aaggaacgaa taaacttgca ttaactccgt 724381 ggaagtttag agatactcat gaaacaacta attattccat tgttgttcca tctgtgtctt 724441 ctgaaaatag attttatatt ccaatgggat tagcaggtgc agatacaatt ttgtcaaatc 724501 taatttatgt aatttacgat gcagaaattt accttctagg cattttgatg tcacggatgc 724561 atatgacttg ggtaaaagct gtagccggaa gattaaaaac tgactatagg tactctgcag 724621 gtttatgtta taacactttc cctattcctg aattatcaac aagaaggaag aatgaaattg 724681 aagaagcaat tcttgaaatt cttgatcttc gtgaagagca gggtggtaca ttagcagagc 724741 tttataaccc ttcaacaatg ccaattgaat taaaagtagc acatgaaaag ttggatggaa 724801 ttgtagaaag agcgtatcgt caaaaacaat ttgaatctga tgaagaacgc ttagaagtat 724861 tgcttaaatt gtatcaagaa atgacagaac ggtaggtgta aggtgtatgg aaaatataat 724921 tgaaattaat tataaccaaa ctggtaaaag taagaaaaca aatgaatacg gtatgcgtga 724981 aatgcaggca agagcttttg aaaaacgtaa ctcacaatat ctcttagtta aagcaccgcc 725041 agcttctggg aaatctagag ctttaatgtt tatcggtttg gataagctca taaatcaagg 725101 tttgaggaaa gtgattgttg ctgtacctga acgctctata ggttcttcat ttaaaaatac 725161 ggatttaaaa agttatggtt tctttgaaaa ttggaaagtt gatcctagaa ataatttaac 725221 tgttggcgga gataactcta aggttaaatc ttttgttcgt tttatggaat cggacgatca 725281 ggtgttaata tgtacgcact ctactttgcg atttgcgttt gaaaaaattg atgataaagc 725341 atttgataat tgtttacttg caatagatga atttcaccat gtatcggcag atgtcaattc 725401 tcgattaggt gaattgttaa gaagtattat tcataattca tcagcacata ttgtagcgat 725461 gactgggtcg tatttccgtg gagattctgt accaatttta ttaccagaag atgaggaatt 725521 atttgacaag gtaacttatt cctattatga acaacttgat ggatatgaat atctaaaggg 725581 atttggtata ggatatcact tctatcaagg ccagtacaca tcagctatta atgaagtatt 725641 ggatacaaat aagaaaacaa tcgttcatat tccaaatgta aactcagggg aatcgacaaa 725701 ggataagtac gatgaagttg gtaagatact tgatatgatt ggtgaagttg aatatcaaga 725761 tgatgatact ggaattattt atgttaagcg acattctgac ggtaaaacat tgaaaattgc 725821 agatttagta gatgaccaag ttggaagaga aaatgtcgtt gcgtatttgc gtaatattga 725881 agccctagac gatttagata taattattgc tcttggtatg gcgaaagagg gctttgactg 725941 gccgttttgt gaacatactt tgacagttgg ttatcgtggc tcacttacag aaatagtaca 726001 aataattggg cgctgtacac gtgatagtta caataaaacc tatgctcaat ttaccaacct 726061 aatcgcaatg cctgatgcaa aggatgaagt agtgacttat acagtgaata caatgcttaa 726121 agctatttct gcctcacttt tgatggagca ggtccttaca cctgacttta aatttaaacg 726181 tagaagaaat gaaagtgaaa aatcttctac tacaggagaa ttattcgtta agggattgaa 726241 agaaccatca acagaaaatg tcaaaaagat tattgaaaat gatattaatg atttaaaagc 726301 aaaaatcatg caagattcac aagtccaaaa aacatttagt ggagaagtag atcccaaagt 726361 attgaacaaa gtgttgattc cgaaagttat tcaaaaagta tatccaaatt tatcagatga 726421 ggaaattgag gaagttagac agcacgttgt tctagataca gttatgaaag gtgctaagtc 726481 tgaagttgta ggaagtaaag aatttataag aatggcagat aagtttataa acattgagga 726541 tttagatatc aatctgattg attccatcaa tccgttccaa aaagcatttg aggttctatc 726601 gaaagaattg aactcaccag tgctaaaact gattcaggaa actattgatg caaaacgtat 726661 taattttgat gaagatgaac tagtattcat atggccaaag gtttaggaat tttatcgttc 726721 aactggtaga agacctgatt caaaatctga agacccactt gaaaggcgta tgggtgaagc 726781 tgtattatac atgcaagagc ttaggaggaa acgtgaaaat ggcaagtaat agataccatt 726841 ctattaatga aatcatggaa agtcagctgt tttaccaaat cacaacacca cctaagaaaa 726901 cacaaaaagc ccagtatgat cctgaagttg aaaagttttt ggagattatt gaattcgtca 726961 aagaaaatgg gcgagaaccc caaaaagtcc ctactgattt aactgaaaga agtttagcaa 727021 gtcgattaat tgggattcgg aaagatcctg atcgtatgga atatttgaaa gagtatgatg 727081 aaattggatt acttgaagta agatcgaagg aactaacaat tcctaaaatt tcttcaattg 727141 atgatattct aaaaagtggc ttatctgcat tattaggtga taatttaaat aatgatataa 727201 ctaggtcaat ttttgataca agttcacttc aaaaggttac gacaatgcct gaatacgttg 727261 caaagcgtaa aaaaataaaa gattttggaa agtttgaaga gctattcaag aagtgccaca 727321 aggaaattac agagggtaaa cgaaaaattt taactttcaa aaatgaacaa gacatacagt 727381 caaatagttt ttatatatta aaaggagttc ttctttatgt tgaagatgtg ggagaacgta 727441 aaaaagcaaa gggaaaaacc aatgctagac ttcgatgtat atttgaaaat ggaacggaat 727501 cagatatgtt actacgttcc ttatcagcgg agttatataa acatggtaga cgtgtgaccg 727561 acaatgaaga tacattgttg gataatgtta gagaagatga tgtttcgact ggctttattt 727621 acgtactaaa atctttgagt acagatccgc aaattagttc cattaagaat ttatataaga 727681 tcggttttac aactggttca gtagaaaata gaatcaggaa tgcagaaaat caatcaactt 727741 atctttatgc tccagtagaa attgtaacca catatcaagt gttcaatatg aatgctagca 727801 aatttgagac ggcaatccat catgcgctag caaataataa tttggatgtt tctattttgg 727861 gggcaaatgg aaagatgtta gttcctaaag agtggttcgt tgtcacactt gaagatttac 727921 aagctgtaat agatgagatt gtgatgatgg ttcatcttta tgactaaatt agtatattag 727981 gattttagta ttaataataa ttttatagta gactatgaaa aaatttgatg ccataacaat 728041 aacttgttcc gctttggagt ttgtcacaat tgtagaatta tgtgttgcga gtattaatag 728101 gaaggggttg agcgaccgca aaaaaaattt tcggtgctgt ccgcaaaagg gagtttgggt 728161 gttttgcgtt atatttggtt gtgtgaaggt tagcggaaac tcaattcgtg aagttaggat 728221 tgcggttatt acgactgagt agtttcgtca tactctttta gcagtttttc tgtcttatgc 728281 atttctttga gcatcggatt catgtagtcg ttagctgatt ctagatatgc tctcgtcaga 728341 gtgtctagtt tatttctaac tttagagagg tcttcttcga attttccatc cgatgattga 728401 aggataaatt cttttgcctc ttcatatctt tttaatatgt ttttcaccat tggagttgga 728461 ttcttttgat ttattgtttt tattacagtg attgttaaat ttatttgttt tattaattct 728521 tttcttactg tcaaggtgat gctcctttta aatctctatt ctatttgaga gttgctatat 728581 ctgtttaatg gtttgataga ctactcatct ttataattta gagcaatttt tacaacttgt 728641 tccgctgtgt aatcttcatt gctccagaaa attaaatcac ttggtgccgg ataaggaaca 728701 tttttctcta ataaatcgag atattcactg actttctcat catctaatgt tgggttcatt 728761 aattccttta caagaaagat caactcttct tttgtcagtt tatccattgt ttgccctcca 728821 atagattgta tctccattga ttttacaaat gactttattt cttctgataa tgttataggt 728881 tgtttgcata atgatagata attgtcttga gaaaagttag tctcattata gagtttatta 728941 attgtattta taacaatata ttcatatgga aaacctctaa aatatcttta ttttagattg 729001 gtttataaaa aatagctcag cagagtaggg ctgagccatt ttttaattat agaccgaggt 729061 aactaattac aaattcttta tcatcctcat cttcaggcaa aataccaagg tttttatatt 729121 cccatattgc gattctttca tatccatcta attctgaggc taaaatatca tcataattat 729181 aatctaattg gaattctccg ctacgatcca atgttagtgt aaggttagtc caaacatcat 729241 cgttattatt tctgtgttca gttcttaatt cttcaaaaag ttctcttagt tctcttaaca 729301 acgtcttgaa aatatccttg cttacgttgt aatggctagg tatatcttgt gaataaataa 729361 tttgattatt ttctggtgtt ctgaaatgaa aaagaaccat tgtggaatca tctaatactt 729421 ctgcataaag atatatcttt gtccattcac caggtatgat gtcattgagt ttttctccaa 729481 taagttgata caaatcttgc atcttcctag tttccattct tctaaccccc aggctgattt 729541 ttaatagaga cgcttatttc ttttctgctc ccaattttgt aggttacatc gaaatatgat 729601 ggtctaagtg aatccccaga atagactggt tctatttgaa ctgctacttt tttaggtggt 729661 tttttgctta gggcttttgc ccactcctgc tccatctcat accatttccc accgctccta 729721 ttaatctgag aattcatcgg cacgatattg tcaaactggc ctgagccttt gaattgggtg 729781 gcgattaaat ggccgccgtc atcgtcaggc tttcggtcct ggggctttcc agcattcgtt 729841 tgtgcatatt ggtttcgttt cgcttctccc agctgcaagt ctgctttgac acttgtaatt 729901 ctaccatagt tgtcagtcgt gtacgtgtag ccttcttttg ttttgtagat gatattaggc 729961 ttcagcactt tctttctgct ccatcttgcg aaatgctcgc cgtatttgac ggttaccggc 730021 ggtacatgtg gcgctggagt tcgtcttccg cttgatgacg ttccgtatgg tttcggcagg 730081 atgaccttgg cgaatttttg cagtccttct ttaagcgtga ccccgttgac tgcgttgtaa 730141 ggaacgcctg ccggcactaa atcatgacgg ggatgatacg ggagaatatc cgcaagtgtg 730201 agatctccga tttgatttaa cttggttttg acgtgttttt ttgatacttc aatgcctgtg 730261 tttacttttt gtttgatgtg atcaacggtt tgttttgaga ctgttatggc tttttgggct 730321 gttgctgatt tgcttgctgc tgttttgact ttggtcgtca ctttggcggc tgtgccagtt 730381 tttgagacgg ctcctacgcc ttttgtgccg acaattgatg tgacaacagt gccaaccgca 730441 tatgacaccc atcttgctct tgagtaggtg tcaccattca ccatgtcttt ttgatacgat 730501 tcttcgattg ccgctgaaat ggcttcatac gttttgatcg ggtgagccat cgctccggta 730561 atcgcttcaa cggttcctcc cggatctgtg accatatccc acaggcctac gaccgcgtct 730621 ttcccggaat cataaaggcc gacggcaacc cctttgaagc ctgcttcaag ctcacgcgtg 730681 ttttcaattt gggtgaagta tctctgttgt tcagctgtca gattttcata gccgatcgtt 730741 tttgccattt cgtagaattc atcggcatct gcataatcgt agtttttcag tctttctttc 730801 agtttctcaa tctcgcgttc cttcgcttcc tctttcttaa tcttcaagta agcctcagtc 730861 cgcttttcaa tgtcgccttt tttcttatgt atgtcactct cacggtacgc cttggcgttg 730921 tagtggatgg gtgtggcgtt tttgccttta cccgttgctt cttggagctt ttggaagtcg 730981 gatttgatga attgttcgtt tggttcagac agggcgtatt ctgttttcag gtcttcgtcc 731041 aaggcgtcca atttttccag tgtttttttg cgtttgtcgt tggcatcggc cagctcgtct 731101 ttgaaggttt ctgttgaaaa caggtcgagc gggaggatgt cgtcgatatc gtttaggatg 731161 tctttcatcg cttttttctg ttcggacatg atggatttag attttttatt ggcatttgcc 731221 agttcgtgct ccaggaagga ttcttcgatg tatgcgtctg agaggccttt gtcttcggcg 731281 gctccggcga tgctgttgaa aaatgcgatt ttcatgtcga tgtagtcgat ccactggtcg 731341 gcgacgccga cgtggtcgtg atagaatgcc ttgatgttgc tggcgccttt tcctgagaat 731401 tcactgtcac tgagatcagc gactcctttt aacgcttttc tcaagttgac catttgcgtt 731461 cttagttctt tgtactcttt tgcacggtct gtcgcttccg aaagcagtgt tttcgcttca 731521 aatactttca tgaccatttc ccttcttttg ttcgctcaat atcaaaattt taccacgggt 731581 cgggataagg tgggggtgag aacgtgtttt ggtggaaaaa tgagtcattt ggcatgtgtc 731641 tttattcgtg gagggattgg aggaaacatg gtcgaaatga tattgattgc tacacatttt 731701 ttggaagttt gtattctata ttgtttttta aggagcatgt tgatgacgaa aaaacggatt 731761 acatttggtt tattagtttt aatggtatgt gtcatcctgt ttgttctgta tgttcagtta 731821 cgcaataaag atagtattcc tgtccaatct tccgccattc accccgaaga agaccgcatc 731881 ttttttattt actccaatcc tttcataaaa gaaagcgtgc tgctttcaac ctctacaggc 731941 gaacggttta acaggcgtac gtttaaggtg gcggatgtgc cttatattca aacgaaatct 732001 tatgcatcaa cagaccttgt attattggcg gaacacgagc ctttttacta cacgctggag 732061 aaggatgtga tcaaagagca tccgctgtca gatccatttg cgttttggta tgaggggaag 732121 gatgtcacta ttgaggccta taatgttgat acgacgggaa atgagatcca cataaacgac 732181 agaaaaacga aaaaggaata tacccttacc ttgcctccgc ttgtcacaat gggggccagt 732241 gatgagaact ttatttatat cattcaaagc atgtctattt acgtgattga cagaaaaaca 732301 gaggaaatga ttgagaccct gagcttagcc tcatacgctg atcaattcgc agactcggag 732361 gaatttatcg tcgcgagctc ggatcataaa ttgactgtga ttgaaaaagg gacatggaag 732421 acgacatata ttgcgtatcc tgaagatctt gaatatgcag atactgtgta ctatgacaaa 732481 gaaagcggca gtttttacgt ggcgtacgag gacaaagagg gtggagcgaa cttgctggaa 732541 tatggggagg atttttctat tcacacatac agcttgaaat tcccttatat ggaggcgaag 732601 tttaagggga atctattgta tatagttgcc caggaagagc ataaaaaggg catcggcgga 732661 tacgtgggtg tgtttgatat ccattctaag gagatgcttt atcagtttga tttgcctgag 732721 gaacaggtga aggttcagga ttttgttgtg gttgacaata agtgaatact atatgaaata 732781 gaatgacaaa gacccttgca taaagggttc ttttttatga aaaaaacaaa ttgacaggat 732841 gaaaaaacaa tttcttcctt ctatattgtt ttcaaaattt gggattgata gaatatgaca 732901 tatctcatag agaaggaggg aagccgttga gtcaagccat accgtcttcg cgtgttggtg 732961 ttaagattaa tgaatggtat aaaatgattc gccagttcag tgttccggat gctgagattc 733021 tgaaagcgga ggttgagcag gacattcagc agatggaaga agatcaggat ttactgatct 733081 attattctct gatgtgtttt cggcaccagc tgatgcttga ttatttggag ccgggaaaaa 733141 catacgggaa tcgccctaca gtgacagagc ttcttgaaac gatcgagacc cctcagaaaa 733201 aactcacagg tcttttgaaa tactactctt tgtttttccg cggcatgtat gaatttgacc 733261 aaaaagaata tgtggaagcg atcggatatt atcgcgaggc ggagaaagaa ctgccgtttg 733321 tgtcagatga tattgagaaa gcggaattcc attttaaagt ggcagaagcg tattatcaca 733381 tgaagcaaac ccatgtgtcg atgtatcata ttcttcaagc cttggacatt tatcaaaacc 733441 atcctctata cagcattaga acgatacaaa gcttgtttgt gatcgccggc aactatgatg 733501 atttcaaaca ttatgataaa gcgctcccgc atttagaggc ggcgctggaa ttggcaatgg 733561 acattcaaaa tgacaggttt atcgccattt ctctattgaa cattgcaaac agctatgaca 733621 gatcaggaga cgatcagatg gctgtagaac atttccaaaa agcggcgaaa gtaagcagag 733681 agaaagtgcc tgatctgctt ccgaaagtct tgtttggatt aagctggaca ttatgtaaag 733741 cgggccaaac acagaaggcg tttcagttca tagaggaagg attagaccat atcacagcac 733801 gttctcacaa attttataaa gaattgtttc tgttcttgca ggccgtgtac aaggagactg 733861 ttgatgaacg aaaaattcat gatcttttaa gctatttcga aaaaaagaac ctgcacgctt 733921 acattgaagc atgtgcccgg agtgctgccg ctgtttttga aagcagctgt cactttgaac 733981 aagcagctgc gttttatcgg aaagtgctga aagcccaaga agatattcta aaaggagagt 734041 gtttatatgc ctattaagaa aaaagtgatg atgtgtctgg ctgttactct agttttcgga 734101 agcatgtcgt ttccaaccct gacaaactcc ggtggattta aggaatcgac agatcgaaat 734161 acgacgtata tcgatcattc cccttacaaa cttagtgatc agaagaaagc ccttagctag 734221 ggctttttct tgctttacgg aagacgttcc attttccaca tcgcggcatt ccttctattt 734281 ctaacgcaag acactcgaaa caaccaaacc atttgaggta taatggataa agtgaataac 734341 agtatttaga ttgatatata tgaaagagag tggaacatca tgggccgtaa gtggaacaat 734401 attaaagaga agaaggcgtc taaggacgca aatacgagtc ggatttatgc gaagtttggc 734461 cgtgagattt atgtggcggc gaaacagggc gagcctgatc cggaatccaa ccaggcgctg 734521 aaggttgtgc ttgaacgtgc gaagacttac agcgtgccga aaaacatcat tgaacgtgcg 734581 atcgagaagg cgaagggcgg agcggaagag aattacgatg agcttcgtta tgagggcttc 734641 gggccgaacg gatcaatgat tatcgttgat gcgctgacga ataatgtaaa ccgtacggcg 734701 ccggaagtgc gtgcggcgtt cgggaaaaac ggcggaaaca tgggtgtgag cggatctgtt 734761 gcttacatgt ttgacgcgac ggctgtaatc ggtgtggaag gcaaaacggc tgacgaagcg 734821 cttgaaatcc tgatggaagc ggatgttgat gtacgtgaca ttttagaaga ggatgacagc 734881 gcgatcgtgt atgccgagcc tgatcaattc catgcggtgc aagaggcgtt taaaaacgcg 734941 ggtgtcgagg aatttacagt agcggagctg acaatgcttg cgcaaagtga agtaacgctt 735001 ccggatgatg caaaggaaca gtttgaaaaa ttgattgatg cattagaaga tttggaagat 735061 gttcagcagg tatatcataa cgttgattta ggtgagtaag gagtgagcag gctgttatgg 735121 cctgcttttt ttgtcccgga aattgtttta gctgtatgta ggcggccgcc tatacgatct 735181 ataagatatt ctcatactct ggactgtaac ctatgtgaag gagagagtaa atatgactga 735241 tacaagacat atgtatggcg gacctggttt tggtcattat cagggctttg gtattggcca 735301 cccgggctat ggcatgcaaa gcacaggcta tccgggctat ggcatgtatg gaggccaccc 735361 gggctatggc atgcaaggct acccagatca cggcatacat ggaggagtcg gcggctatcc 735421 gggatatggt gggtacggcg gttacccaag cggcggctat ggaggctctc cgggaactgg 735481 aagctatccg agcatgcacc atgaaaatga tggccatcac cactattatc accatcatca 735541 tgatggaaaa gataatcttc atcaccatca tcaccatgtt ggaaaggata atcatcacca 735601 ccatcatgat ggtcattatg gccaccatca tcaccatatg ggccactggg gaaaagacgg 735661 ttataaataa agaagatgat gataaaaaga ggacactctt gcagatcaag agtgtttttt 735721 tagctttttt cttgactgtt cagtctggaa aatggtaaca tttgtttcag gaggtgatca 735781 ttttttgggg aggaataaag aatttgatac ggcgcttgtt cttcacaggg cgatagaggt 735841 ttttggagag tatggctacg aaggaacgtc tcttcaggat ctgctctctc atttaggcat 735901 tgcgcgccaa agtttgtatg atacgtatgg aacgaagcgt gatttgtttt tgtccgctgt 735961 gaaatcgtat cttgaaggga aaaacgctgc cgttatggaa aggcttgaag cgccaggatc 736021 tgtaaaggaa gccattcgtg atatttttca ggagggtgtc aatgccctga gggatccgga 736081 acgggcgaag gcgtgctaca ttattaacag cgcgattgaa cagatcccgc atgaccctga 736141 gcttgcccgg tattttgaaa gacaatccaa gcagcttgag gacgcttttt atcacgggct 736201 tttaagagcg aaggatcaag gagaattgaa tggcgaagat actgatatat ctgcgcttgc 736261 tcggtacctg aatcagagca ggctgtcact gacatttatt gcaaaagtga cggcagatat 736321 ggatcggctt caggaccatg ttgacgtgag tttatcagtg cttgattaac atgtggtaaa 736381 ggattctttg cccatgtatg tactttttgg actgaatagt ctagaaataa aaatgaggtg 736441 atgatgaatg ttgatgaatg agtttgaaaa agcatgtgaa acattgagaa agtttatggc 736501 ttatatgctt gagaaggaca tgaagagctg gacggagctt tgggatgaga atgctgtatt 736561 tgagtttcct tatgcgccgg agggatcacc aaaaagaata gaaggaaaag cggccattta 736621 cgattatatt aaagattatc ctaagcagat tcatctttct tcatttaccg ctccgacagt 736681 gtaccgttca gcagactcga atacggtgat tgcggagttt caatgtgacg gccatgtgat 736741 tgagactgga ctgccttatc gccaaagcta tatcagtgtc atcgaaacga gagacggccg 736801 cattgtgcgt tatagggatt attggaatcc gcttgttgta aaagaggcct ttggaggatc 736861 atttttgcaa acagaggaga gtgggaaatg atgaaacaga atccgatttt aatcacgggc 736921 gggaccggca cagtcggcag ccgaatcgcc agccgtttaa taaagctggg atacagagtg 736981 cgtattgcaa gccggaaaaa gggcgcgctt gctgatgctg agtatgtgta ttttaattgg 737041 aagtacgcct ccagttttac gcctgctctg gaacaggtaa aacagatcta tcttgttgct 737101 ccggtcggtg tatttgatcc ggctccctat gtgcttccct ttttaaagga agcaaagcgt 737161 ctcggcgcaa agcgggtagt gatgcaaagt gcgtctgttg tctccgagaa cggtcccgtg 737221 tttggcgcgc ttcaccaggc agtgcgcgag tttccagaat ggacggtgct gcggccctca 737281 tactttatgc aaaatttcat caatgtccag caccgcatgt ctattcaaac ggaggggcgc 737341 atcacaacgg cttcgggtga aggaaaactt gggtttattg acgctgatga catcgcagaa 737401 acagccgtca gggctttgat tgatgatgtt cctcatcaaa cacatcatat tctgacaggt 737461 cccgaggcgc tgagctatgc cgaagcggcg gagatcattg gagctgcggc gggacgccgg 737521 gtggagcatg tcagcatttc tcgttccgag ctgcagcata aaatggaggc aggaggtttg 737581 cccgcggatt atgcccattt tatggcgaag cttgatgagg caattagcca tggtgcggaa 737641 catcgggtaa cggatacagt gaagcgtgtg acgggaaaag aacctcgttc gctgtcagag 737701 tttgcggctg ctcatgctgc atattggacc tcattttgga ctgaatagtc tagaaagacc 737761 ttcggcgctt ccgaaggtct tcttattgaa aaagctaagt cgtgttttag tcataatcat 737821 gcctcctgcc tcatacctat taaggtcatt gtttttgaga aaggaggagc cggaatgaag 737881 gatatgcagc cgtttacgcc tgtcaaatca tatacgccct ttcacagccg ttttgatccc 737941 tgtccgccca tagggaagaa atattacaga acgcccccta acctttatat gacctttcag 738001 cctgagcaca tggagcagtt ttcgccgatg gaggctttga ggaaaggcac cctttggaag 738061 gatctctatg atttttatga aaacccttat cgagggggag acgcacatgg caaaaaaggt 738121 tgacgccgaa tattatcgtc agctagagca aatacaggct gctgattttg tgcttgttga 738181 gctgagtctt tatttaaata cacatcctca tgatgaagat gcgttgaagc aattcaatca 738241 atattccggc tattcaaggc acttaaaaag acagttcgaa tcctcttacg gaccgcttct 738301 gcagttcggc aacagccccg cgggcaagga ttgggattgg ggaaaagggc catggccgtg 738361 gcaagtataa ggaggaatgc ctgaatgtgg gtgtatgaaa agaagctgca ataccctgtc 738421 aaggtcagta cgtgcaaccc gacgctggcg aagtatttga ttgagcagta tggcggagcg 738481 gacggcgagc tggccgcggc tctccggtat ttgaaccagc gttatacgat tcctgataag 738541 gtcatcggcc ttttaacaga tatcggcacg gaggagtttg cccatttgga aatgattgcg 738601 accatggtct ataagttaac gaaagacgcc acaccggagc agctgcgtga agctgggctt 738661 ggcgatcatt acgtcaatca cgacagcgcg cttttttatc ataatgcggc gggcgtgccg 738721 tttaccgcga gctatatcca agcgaagggc gatccgattg ccgatttata cgaagatatt 738781 gccgcagaag aaaaggcgcg ggcgacgtat caatggctga ttgatatttc ggatgatcct 738841 gatttaaacg attccctgcg ttttttgcgt gagcgtgaaa tcgtacactc tatgcgcttc 738901 agagaagcgg ttgaaatttt aaaagaagaa cgggataaaa agaagatttt ctaataggca 738961 gattggcctc tctttcatac acccttttac atacagagaa aatggtctgt ttttgcagtt 739021 tggtctgcat tataatcaag gtgtgtgtgc aagcttactt tttgattggg aggcctttat 739081 gacagctttt aagattgaga acgaaacgat tgcagatgga ttttacgcgt gtccggccgt 739141 ctatgaggat gcagaatcga ttaccgggtt gctcgtccga acagctgaat ggctccggga 739201 tcggggttct aaccaatgga gcggacttct caaagggcaa gatatacatg atatcacggg 739261 gtcaattgaa aagggacatg tgtttgtgtt taaaaaagat gaagagcttg cggctgtcgt 739321 gatgctgctg cctgcaccga gcgagtggga ccggacgctt tggggagacg atgggcatga 739381 ggagtccatt tatttacacc gcctcgcagt aagccgccgg tttgcgggac aggggcttgg 739441 agcccgcgtc cttcagtggg cggagacggg catacacttt ccggaaaaaa cgcggatccg 739501 gcttgactgt gtcgctgata gtgacgccct gcattccttt tatcggcgta tgggatatga 739561 attcatgggt gctgatgcgt ccggatatca tttgtttgag aaagagatta cggcagaata 739621 agcgtccttt gcagggggct tttttgtctt tttctaaaag ggaggcaggc gatgtgtggt 739681 caatattatt tgtgacaggg attgtgacgg cttgtctgtt tgctggcgta tccgtattga 739741 tgcggatgag atttcctgac aaaagtcggc cggaatggat gttggccggg ctgatcgtcc 739801 ttggtgtgtt tgcgatctgg tacagcctcg tgtatgtacg cggctgggaa ggggctgcgc 739861 tcggaatgct tggattcaat gtcattttcg gagccattgc cggatatttg atcgataagg 739921 ccatccggcg ttacaggaaa agataaggct gctgccgtct ctcaacaggt cgaaattttc 739981 acagaccggc aggaattttc tttcgaaagg agaaatacat attactttaa aatgaaagcg 740041 ttttccaaag caggaaggtg atgttgatga tacacagtgt ggcaaatggg ctgaatcatt 740101 tttgtacgtg ggtgatgaga ctggcctatt tgaatgtgct ttggattttg ttttctcttg 740161 caggcctggt tgtatttggg ctgatgcccg ctactgccgc gatgtttaca gtggcgagag 740221 aatgggcgaa ggggaataca gatgccccgg tgttttctgt cttttttcgg acgtttaaaa 740281 aggaatggcg ggcatcacag atcctcgggc ttatcgttgt gacggctgcc ctgtttctgt 740341 ttgcggatat gcggatagcg gctcagatgg accagcctgt gctcgtcaat gtattcgtga 740401 gcattagttt gattttcgcg tttgttgtgc tgtatgtgtt cccggtattt tctcattttg 740461 acgtaaaaat cagagaggtg ctgagcatca gctttttcat tgccttcagt cgtccggcgg 740521 tgacgctttt gatggcagcg ggcgctgtcg gtgtgctttg tctcgttctg tttcatgtca 740581 cgtttctatt gtttttcagc gggagtttac tcagcctgat cttaacgaag ctgtccttta 740641 aagcgtttcg gtcaatggat cagcggcagg agaaagaaaa ggcggcatga agaaaagagt 740701 tgctggctgg tacaggcgga tgaagattaa ggataagctg tttgtgtttc tatcgttgat 740761 tatggccgta tcctttctgt ttgtatacag cggggtccag tatgcctttc atgtgtatga 740821 tgagcagatt taccgcaagt cctcggaggt gcttcggatg tcttctgaaa ggatcgaaga 740881 cgagctgaag aagatagagg atgtgtcata tgaaatcatt acagacgaac agattcagcg 740941 catcctgagc atgcaaaatc gggatgatac gtatgatcaa tatcaaatga agcaggagct 741001 gtgggatcag cttgcgggat atgccagcga tgaaaagtac atcgattcca ttcatgtgat 741061 tgatgcccgc ggctcagagt attcagccgg aagcagttct tcagatcttt tgcagcagga 741121 gcaggaagag gtatttaagc gagcgaaagc gaaaagtgga agaaatcttt ggatgacgct 741181 cggcgggtca gaccccgtcc tgatttcagc acggcagatc aggtcctatc accagctgag 741241 tctgaacggc ttgggcatgg tactgatcca ggtcaatgta aaacagatga ttcgtgatgt 741301 gccgaaggat tggggcgatt cagtcggaga cattatgatt gctgaccaag gcggtaattt 741361 ggtgtatacg gcacatgcat cagcgcatgt tcctgaggca gcaaaagaga cgttgaagca 741421 ccccggttat gacttgataa aaaagaatgg caaacgttac tttatttctt atcttcaatc 741481 atcctaccaa aattggagct actataacgt tatccccttt gatcagatgt tcgcaaaaat 741541 ttcctttatg aaaacagtga tcggcacatg ctttcttctc tttttctgtg tggttttgct 741601 tttcggaagg aaaatcgcca acagcatcac ggagccgatt gaacagcttg tgaccgcgat 741661 gaaatcggta cagcacagcg gcattgaagc aggtgtgtcg ctttctctgc cggaacatac 741721 acaggatgag gccggcatgc tgaaccgcca ttttactgtc atgatgaaac ggattaatga 741781 gctgatggaa gaaaatgtgg aaaaacagct catcattaaa gaaaccgaat tgaaagcact 741841 gcaagcccag atcaatccgc attttttata taacacgctc gagtccatca attggctggc 741901 caaggcgaat cagcaaaagc aaatctcaaa aatggtggaa tcgctcggtt ttcttctgcg 741961 aaacagcata catatgaaga aggatatcgt gaccattcag gaggaggcgg acattgtacg 742021 tcactatatg accattcagc gatttcgatt tgaagagcgc ctgaaattca cgttggatat 742081 tgacgatgag gtgaagcatt gcctcattcc gaaactgacg ctccagccgc ttgcggaaaa 742141 tgcgattcaa tacgcgcttg aaccctttac aaggccatgc gccatccgga ttcaggcgaa 742201 aaaggcgaag ggctgtgtct gtattacggt cgaagataac ggccctggca tggatggacg 742261 gattcttgaa tcaacgggtg gaagaggaat cggactttgg aatattcgcg agcgcatcag 742321 cctgacattc ggagagccat acggattgcg gattcatagt gagcatgaaa aggggacgag 742381 gattgtgatc acaataccgt gccgaaatga ggtggtgtga tgtataaaat actgctggct 742441 gatgatgaga ggattatcct tgatggaatg gcgggaatca ttgagtggga gtcgcttggc 742501 gcctcattga tcggaaaagc gcagaacgga catgaagcat atgaaaagat tgtacataag 742561 cagccgcata tcgtcatcac agacgtcaaa atgcccggca tggacgggct tgagctgatc 742621 aaaaaggtgt cagccgtcag cccgtcggtg caatttatcg tcctgtccgg gtttggagag 742681 tttgagtacg caaaggaagc catgaaatat ggggtgaagc attatttgct gaaaccctgc 742741 aatgaacagc agattatcag ctcgctggag gaaatcattg ctgagctgaa gcggcaagat 742801 gtgcacaaaa agaaaacagc ccatctgaaa cacgagctgg accatatccg ttcctttgca 742861 gccgatcaat acttggaagg cttgatcgcc ggtgtggccc agctttctcc gccgccttca 742921 cttgccggaa aaaagatccg cctcttgatc ttaaaagggg aacaatctat tgatgctgca 742981 gccagagagg cactcggatc ggcactgaca gcggtttgca gcagcggtga atggaccgtg 743041 ctcgccgtag aggagaacgc cgctgaaaag gtggcggagg tttttgcgga ccgcaagatg 743101 gccatcagtc aggcgggaga actccggcac gcggggcagc tgtttcgtga cacagctgaa 743161 gcgtctggtg acctgcatgg gagcgcagtg atttcaaaaa tgatcaggct tattgccgac 743221 gagctcggaa atccgaatct gtccttaaaa tgggcggcga aggatatgct gtttatgaat 743281 cctgattatc tcgggaagtt atttaagcag gaaacaggcg agaaattttc ccaatatgtt 743341 acacgggtgc gtcttgagca tgcgatgaag cagatgaaaa taaggaggga cgtgagcgtt 743401 tcagaaattg ctgaagaaat cgggtttggc gataatccga agtatttcag tcttgttttt 743461 aaaaaatata ccggtctgac accgtcagaa ttcagaagaa aacagggagg cgcttccgca 743521 ggatagccat ctctgttttt ttgactttcg ccactgtttt ttgagtgttt cgccctatcc 743581 gaacgcttta aaataaaatg taagcactta cattaaaggg gggattggtt tgaagaagat 743641 ttgttacgtg ctgttatccc ttgtctgcgt ctttttgttc agcggatgtt cagcgggtga 743701 agaggcctcg ggaaaaaaag aagatgttac actcagaatc gcgtggtggg gcgggcagcc 743761 aaggcatgat tatacaacta aggtaattga actatacgag aaaaagaatc cgcacgtcca 743821 tattgaagcg gaatttgcga actgggatga ctactggaaa aagcttgcgc ccatgtctgc 743881 cgccggccag cttcctgatg tcattcaaat ggataccgct tacttagccc aatacggaaa 743941 gaagaaccag ctggaagatt taacgccgta tacaaaggat ggaacgattg acgtcagttc 744001 aatcgacgag aatatgctgt cgggcggaaa aatcgacaat aagctttatg gatttacgct 744061 aggtgtcaac gtgctgtctg tgattgccaa tgaagatttg ctgaaaaaag ccggtgtgtc 744121 tatcaatcag gaaaactgga cgtgggagga ttacgagaag ctggcgtatg atcttcagga 744181 aaaagccggt gtctacggtt ccaacggaat gcatccgcct gatattttct tcccttatta 744241 tttgcgcaca aagggtgagc gcttttataa agaagacggc actggcctcg cgtatcaaga 744301 tgatcagctg tttgtcgatt actttgaacg gcagctgagg ctagtgaaag cgaaaacgtc 744361 cccaacacct gatgaaagcg cacagattaa agggatggaa gacgatttta tcgtcaaagg 744421 caaatcagcg attacatgga actactccaa tcaatatttg ggctttgccc ggctgacaga 744481 ctcgccgctg tctctctatc tgccgccgga gcaaatgcag gaaaaggcgc tgacactgaa 744541 gcccagtatg ctgttttcca ttccgaaaag ctctgagcat aaaaaagagg cagcgaaatt 744601 tattaatttc ttcgtgaata atgaggaagc gaaccagctg attaaaggcg agcgaggcgt 744661 tccagtctcc gacaaggtgg cggatgcgat taaaccgaag ctgaatgagg aagaaaccaa 744721 catcgtggag tatgtagaaa ccgcgtcaaa aaacatcagc aaagccgatc cgccagagcc 744781 tgtgggaagc gcggaggtca tcaagctgct gaaagatacg tcagatcaga ttctgtatca 744841 gaaggtatcg ccggaaaaag ccgccaaaac gttccggaaa aaggccaatg agatattaga 744901 gaggaataat tgacgggaaa tggggctgac gcaatgaaaa aaagccggag tataagaaaa 744961 gacaatctgg cgggatatgc ttttatttct ccgtttatca tcgggttcct atgctttacg 745021 gtgattccga tgggggcgtc cctgtttctg tccttcacga gctatgactt gtttacggcg 745081 ccgaaatgga tcgggctcga caactttaag gaaatgttta cgggtgacga aaagtattgg 745141 cagtctctga aggtgacgtt tacgtatgtg cttgccgggg ttccgctccg cctcggcttc 745201 gcgcttttta tcgctgtcat tttaaacaat gcagcaaaag gaacggccat ttacagaacg 745261 ctcttttatc tgccttcgat catcggcggg agcgtcgccg tggcgattat gtggcgcaat 745321 atttttggca atgacggggt catcaatgcg ctgctgtttt ttgtcgggat tgatcaaaaa 745381 attctttggt accagaatcc gacaagtgcg ctgtggacat tgattctgct gtccgtctgg 745441 cagttcgggt cgtcaatgct gatttttttg gccgggctga aaaacattcc gtcttcgtat 745501 ttggaagcgg caagtgtgga tggggcaaat cgggtgcagc gtttcttcaa gatcacgctt 745561 ccgatcctta caccgattat tttctttaac ctagtgatgc agacgatttc tgcttttatg 745621 acatttacac ctgcctatat catttcgaag ggcgagggcg ggccgcttga cgggacactt 745681 ctctattcgc tctatttgtt ccagcgtgcg tttaactatt ttcaaatggg ctacgcatcg 745741 gcgatggcgt gggtcatgct tgtcattgtc gggctgatta cgctcatatt gtttaaaaca 745801 tcgtcatatt gggttcatta cgagtcaaag gaggaatgac ggatggagcc ggtcaaccag 745861 cctgtcagag aagccccggt ttttgagaga aaaaaagccg ggcgcgtcag tcccaaacgc 745921 atactgttcc atgtttttac ggcaacgctg gcggtgttgc tgctgtaccc ggttatttgg 745981 ctgtttgtca gctcgtttaa agaaagcgcc agtattttta caacctcaca ttctctcatt 746041 ccagaccctt ttattctcag taactatgct gaagggtgga agggcattgc gggacagccg 746101 tttctgacgt ttattaaaaa ctcggcgatt attgtcgggc tgtcaacaat cggtgccgtc 746161 atgtcatcgg ctgtcattgc gtacggattt gcgcgtatac cgtttaaggg aaaaaaattt 746221 tggtttgcgt gcatgatggg gacgttaatg ctgcctcatg aagtgttgat gattccgcag 746281 tatattatgt ttgcgaaatt agactggctg aattccttta aaccaattgt cgttccgcaa 746341 tttttcgggc atgcgttttt tatctttctg atgatccagt ttatccggac gattcccgag 746401 gagctggatg aagccgcgcg aatcgacgga tgcggacgct ttgcctgctt ttggcggatc 746461 attctcccgc tgattgcccc cgcgcttgcg acgtctgcga ttttctcctt ctattggaag 746521 tgggaggagc tgattcagcc gctcttgtat ttgaataagc cggagcttta ccctgtttca 746581 cttgcgctga agctttttct cgatacagag tcggcttcga actggggcgc gatgtttgcc 746641 atgtcagccg tctcgttatt gcctgtgatt cttgttttct ttttgtttca gaaatatatc 746701 gttcagggca tcagtacgac cggattaaaa taaaaaggag tgttgcagat ggcacagctt 746761 atctttgatg aagaaaaggt gacgtcggtt attgaccgga tcgtgaaacg gacatttcag 746821 atggattttg cgtgggattg gccgggcggc gttgcgtttt acggtgtggc ggaggcctat 746881 gaagcgacgg aaaacgagga atatatcaat ctgttaaaaa cgtgggtgga tgaacagctg 746941 gaggatgggc tgccgccgct ttcgatcaac ggagtttcca ttgggcatac gcttttgttc 747001 ctccacaagg tgacaggtga tgacgtgtat ttggaaacag cggccgagat ggcggaatat 747061 gtgctgcata aggcgccgcg ctttggcgag ggtatccttc agcatacggt gaatgcggca 747121 gaatacgtat tccctgaaca ggcatgggcg gatacgctga tgatggctgg gctgtttatg 747181 ctgagaatcg ggcgggtcat ggagcgtgag gattattttg aagacggcct gcgccagttt 747241 cacggacatg aggatgtgct tcaggaccct gtcacgaatt tgtactacca cgcctgggac 747301 aacaaagcgc aaaatcatct gtcggggatt tattggggca gggcgaacgg ctgggcggca 747361 ctcacgatgg caaaggcgct cccgcttatt gaggtgacac atccttcctt tatgatcatc 747421 gacggatcgc tcagagacca gctgagcgcg cttgtccggc ttcaggatga atcagggctg 747481 tggcatacaa ttttggatga tccggattct tatctggagg tttcggcatc agcgggtatt 747541 gcttctgctc tgatgtcgag cggaaagctg tatacaaaat atgtgcagaa atcgcttgcc 747601 gccattttgg atgcagtgga agaggacgga cgggtcagca gggtatcggc cgggacagcc 747661 gtcatgaaaa atgccgaagg atacaaacag gtgccttaca aacgaataca aggatggggg 747721 cagggacttg cgctgacgtt tcttgctgat gttttgaaaa cgaaaaaacg cttgtatcag 747781 taaagatagc ggcgggggga gagggatgaa aaaacagcct caacagaagg aacgggtttc 747841 tcgctggaag ggaacgtatt tcaaaagaaa ctttgtcttc attttgctga ttgcctgtat 747901 tcccggattg ctgactggcg gcgcaatcta ctttctttcg atcgacaagg tggagaaaga 747961 gctgcagaga tcgcatgaaa cacaggtggc gcgtgaggtc agccgaatgg atgagaagct 748021 gggagtgctt gaactggcac tcacccagat ggcctacgat tcttcactga tgaacggatt 748081 ggccgagagg gatttggaga aagactttac gttctcctat caattaacga aaaagctgtt 748141 tcttttgcgg gatcagcagc cgctgatcga gcaggcttcc atctttctga acagcccccg 748201 gccacttgtg ctgagccctg aatacagcgc tttgacagaa caggaggcgc ttcgcaagta 748261 tcgctcgctg cttgcctcag accacagcat ttattggaaa cggtcgggaa accaagcgat 748321 gctgatccag ctcattccgg gcgcggcgga gaaaccgttc ggcgcgatca tgctggcggt 748381 tgatccgaaa gaaatggaat caatcctgca aagcttgtcc ccctatcctg atggcagtgc 748441 gttgctttta gatcaaaatc gagaggtgct gtttcatgag ggggaaaaag attttgaaaa 748501 gactttactt catgagataa aaaaacagcc tgctgagaac ggccattttc agatggaatg 748561 gaaaggcaag gtgtattctg tctcctttgg agaaatgaac cggatgcatc agcaatggac 748621 ctttgtgtca gcggcgcctc tttcagctat tacagcgccg atggtgtttt tatcaaaagt 748681 gatcatcgtg atgctggtca tttgcatcgg tttggcggtg tgcatgacat ggtatgcatc 748741 aaaaaaaatc tatcgtccca tccagcattt gcttggcttg tttaccggag gagagaagaa 748801 aacatggcag gcgtccgggc aggatgaatt caaatggatt gaaaagagat ggcaggatct 748861 atcccttgaa agccggaagc tccaacagca gctcctgcgg cagacgcccc atatgaaaaa 748921 gagttttttg cagcatctct tacagagcga tttttactat gacaacgagg aaagcctcag 748981 atttcggatg gaggaggctg gctggaacat cggcggaaac gtgtttcatg tgcttgatct 749041 acaggtgaca gggctccgct gtgaaaaaag catcttccgt gaaggtgatg aacagcttgc 749101 cgtgtttaca ctgactaata tcgctgagga attggcggct aaacgcgttt ttcagctctc 749161 catacttgat atcggccggc tttctgtcac cgttcttgtg atgaaaacaa acagctctga 749221 tctgaaggcg tatataacgg agctggcacg ccaatttgga gatgtaaccg gactatgcct 749281 gacctcgaca ttgagcagca agacggagcg tgtcacggaa attccttctt tatttcagga 749341 tgtgaaatgc ggcaaatccc gcaggaagtt tgctaaccgg gatcaggtca ttgatttgca 749401 ggccgacttc cctcgggatg agcagttcgc tccttattac ccttttgagc tggaaaaaca 749461 aattgttcag accatccggc tggaaagaaa acaggaagcc aaggaactga tagatggatg 749521 tatgaaggaa ctgtcggaaa aagcggccat agacaggcat gtgcattccg ccctgattca 749581 gctgttttcc cgcattcagg aggatatttt gcattccggg ctcaatccca gcgaactgtt 749641 tcagcaccgg aatccgtttc ttgatatttc agaattgcgc gaacctaacg aagcggcggc 749701 ctggctgatg gatgtagtgg tgacgcctta cctttccaag cttgagggca gaaaaaacag 749761 acagcaaaag cagctggcag aacgtgtgat tgcgatgatt cacgaacagt atatggcgga 749821 catttcattg gaaagctgtg ccgatgcgct tggcatgaat tcctatacgt taagcaaggc 749881 atttaagcaa gtgaccggca ttaattttat cgattatgtg acccagatca gaatcgaaaa 749941 ggcgaaagaa ctgctggtca atacgaataa aaaaattcat gatgtgtctg aagaagtcgg 750001 ctatcgccac aattatttca atcggatttt taaaaaacag gtcggcatgc cgccgggtgt 750061 cttcaggcaa atgtatcagg aaacgccgtg aaaggagaga acatgtgatg aagaaaccga 750121 ttcaagtatt tttagcgggg gattccactg tgagtgactg cccgcctcat gaagcgccga 750181 tggcggggtg ggggcaggta ttcgggcaat tgttttctga aggtgtgctg gtccgcaatc 750241 atgccaaagg aggagcgagc accaattctt ttgtggagga aggaaggctt caagcaattg 750301 ccgagcacat cacacaaggc gattatttgt tgattcaatt cggccacaat gaccaaaaac 750361 cgcgggggac gaagccgtac tccacatttc agcagtttct taccttgttt gcagatacgg 750421 cacgcgaaaa gggcgcgcat cctgtgttcg tcacatcggt gcagcgccgc cgctttgatg 750481 aaaacggacg gatcgagcat acgctcggtg agtatcccga tgcgatgaaa gcactggcga 750541 aggagctcga tgtacctgtg attgatctgc ttgcgaaaac aaaggtgctg tatgaagcat 750601 acgggccgga ggagtcgaag cgattgttcg tttggtttca gccgaatgaa catccgaatt 750661 acccggacgg cattgaggac aatacgcatt tttcggaaaa aggtgcaatg gaggttgcga 750721 agcttgtggc agaaggcatt gaagagctcg gacttccgct taaggaccac cttgtgagcc 750781 gggagggaaa agaacatgta taaggaaggc gcttgcttgt accgcaatcc gctccggtct 750841 aaaagcgatg tgaaggattg gcggatggag ggaggcggac agatctcatt tgacgatcac 750901 agcttgcacc tgtcacatgt ccaggatgaa gcgcactttg tcttttggtg tccggaaacc 750961 tttccagacg gcatcattgt gacatgggac ttctctccga tcgagcagcc tggactgtgt 751021 atgctgtttt ttgccgctgc gggtattcgc ggcgaggatt tgtttgaccc aagtctcagg 751081 aaaagaacag gaacataccc tgagtatcat tcaggagata tcaatgccct ccacctgtcg 751141 tatttccgca gaaaatacgc ggaggaaaga gcgttccgca cctgcaattt aagaaaaagc 751201 cgcggtttcc atctcgccgc aatgggggcc gatccgctgc cttctccaga cgacgctgat 751261 tctccgtatc gtatgaagct gatcaaagac aaaggctatg tgcacttttc aatcaatggt 751321 ctgcccattc ttgagtggat ggacgacggc agcacatatg ggcctgtgtt aacaaaagga 751381 aaaatcgggt tccggcagat ggcccccatg aaagccgttt acagggattt tgccgtgcat 751441 caagcggtga gaagatgaag acgactgtaa cggatgcgct ttatgcaggc tgcgaagcgg 751501 tggtgaaaat agcatggctc aacgggctgt ggctgttgtt tacacttttg ggcggcgttc 751561 ttttcggatg ggcgccgagc acagctgcga tgtgtgccgt tataaggaaa tggctgatgg 751621 ggcaaaagga tgtcccgata ttttcgttat ttctcgatac ctataaaaaa gagtttctca 751681 aggttaatgc gatcggattg gcgttttcgg ctcttttgct catattgtct gccaactatc 751741 attatttttc tgccagtacg aattggctgt cctttgccgt aacaagctgc acgctgcttg 751801 cagggctttt gtatatcatc gcgctgatgt atgtgtttcc cctttatgtg cattaccagc 751861 tcccgcttcg caaatatatt ccgcaggcac tgctgtttgg cgccatgaga ccgctgacaa 751921 ctggctgtat gctgatcggg tgcggatttg tcctttattt gctgtatacg cttcctggcc 751981 tgatcccatt ttacggcccg tgtttatttg ggcttgtgtt gatgtttttt gctcttaggg 752041 gatttcaaaa gacggaggcc cagcaccatc aagccgggta acaaaaaaat gacaaataag 752101 caaaaaagtg cagtgtccga aataggcaga tgcaaaaaag tgaaattgaa gacagctcac 752161 aaagcgcata aaatccaatt taagtaagcg cttacagata aatgagaagg agctgtctga 752221 tgattagacg aaggaaacgc atgtttaccg ctgttacgtt gctggtcttg ttggtgatgg 752281 gaacctctgt atgtcctgtg aaagctgaag gggcagcgcg gcagatggaa gcgctgaacc 752341 gggggcttgt agcggtcaag acggacgggg gcatttttgt cagctggcgg tttcttggaa 752401 ccgaaaacgc atctgttttg ttcaatgtgt acagagacgg gcaaaaactg aatgctgcgc 752461 ctgtcaaaac aacgaactat gtggataaaa acggttcggc gggctcaacg tatacggttc 752521 gggctgttgt aaacggtacc gaacagccgg cttctgaaaa agcctccgta tgggcgcagc 752581 cgtatcattc cgtcccgctg gataaaccgg ctggcggcac gacgccaaag ggtgaatctt 752641 acacgtacag cgctaatgac gcaagtgttg gcgatgtgga tggtgacggg caatacgagc 752701 tgatcctgaa atgggacccg tccaactcaa aagacaattc acaggatggc tatacgggtg 752761 acgtgctgat tgacgcgtat aaactggacg gcacaaagtt atggcggatc aatctcggca 752821 aaaacatcag agcgggcgcg cactacaccc agtttatggt gtatgacctt gatggtgacg 752881 gaaaagcaga agtggcaatg aaaacggcag acgggacaaa agacggcacg ggcaaagtaa 752941 ttggaaatgc caatgcagat tacagaaatg aacaggggcg tgtgctttca ggccctgaat 753001 atctcactgt gtttcaaggt tcaaccggga aagagcttgt caccgcaaat tttgaaccgg 753061 cgcgcggcaa tgtgtcggat tggggagaca gctacggcaa ccgtgttgac cgttttctcg 753121 ccggcattgc ctaccttgat ggacagcggc cgagcctgat catgaccaga gggtattacg 753181 ctaaaaccat gctagttgcc tataacttca gggacggaaa gctgtcaaag ctttggacgc 753241 tggactcctc aaagtcagga aatgaagcgt ttgccggaca ggggaatcac aacctgagca 753301 tcgcggacgt tgacggggat ggaaaagatg agattatttt cggctcaatg gctgttgatc 753361 atgacgggaa aggcatgtac tcgaccggct taggccatgg ggatgccctc catacaggag 753421 atcttgatcc gggccggccg gggcttgagg tgtttcaagt tcatgaggac aaaaatgcaa 753481 aatacggctt atctttccgg gatgctgcaa ctggaaaaat cctttggggc gtttatgccg 753541 gcaaggatgt aggccgggga atggctgctg atattgaccc gcgttatccg ggacaggagg 753601 tgtgggcaaa cggttctctc tactcagcga aaggggtcaa aatcggaagc ggggttccgt 753661 cctcgaccaa cttcggcatc tggtgggacg gcgatctgct ccgggaacag ctggacagca 753721 accgaattga taagtgggat tatcaaaacg gcgtatcgaa aaatatgctg actgcatcag 753781 gcgcagcggc taacaacggc acaaaagcaa caccaacgct tcaggctgat ctgctcggtg 753841 actggcgcga ggaagtggtg tggagaacgg aggacagcag tgctctgcgc atttacacga 753901 cgaccattcc gactgagcac aggctgtata cgctgatgca cgatccggtg taccggcttg 753961 gcatcgcctg gcaaaatatc gcctataacc agccgccgca cacaagcttc tttttaggag 754021 acggcatggc ggaacagcca aaaccaaata tgtatacgcc ttaactgaaa gggggaagga 754081 acgggctgcg cgcagcccgt tcccatcaaa tgaaaccaaa aaagaggcaa atggaatacc 754141 tgaccagagg tttgattgcg gtacagacag aacagggcgt gtttgtcagc tggcgttttc 754201 tcggcacgga tcatgagacg acggcttttc acctttatcg ggatggaaag cggatcaccc 754261 gcgatccaat cgctgaaagc actaattttc tcgatcaaaa cggaacggct gactctgttt 754321 atcaagtggc ggctgtcaat aaaggacggg aagaaaagct ttccaagaaa gctcgtgttt 754381 ggcaggaaaa tgtcctggag gttcctcttg ccaaaccgga aggcggtgtg acgccggacg 754441 gaaagccgta cacttacagc gccaatgatg ccagtgtcgg ggatatagac ggggatggag 754501 aatatgaaat gatcctgaag tgggacccgt ccaattcaaa agacaacgct catgacggtt 754561 ataccgggga ggtgctcata gatgcctata aactggacgg cacctttttg tggcgcatca 754621 acctcggcag aaacatcaga gcgggtgctc attacacgca atttatggtg tatgaccttg 754681 acggtgacgg aaaagcagaa atcgccatga aaacagctga cggcacaaca gacgggaaag 754741 gacatatcat cggtgatgag caggccgatt ttagaaacga acagggcaga attttgtccg 754801 gtccggaata tttgaccgtg tttaaaggag aaaccggtga ggcgctcacg accgtggaat 754861 atgaaccgcc ccgcggcaag ctggaggatt ggggagacgg ctatggaaac cggatggacc 754921 gttttctcgc cgggaccgct tatttggatg gggagcggcc gagccttgtt atggcgcgcg 754981 gctactatac gagaaccgtg ctcgtggcat acgatttcag aaacggaagg ctcaaaaaac 755041 gatgggtatt tgactccaac cagccgggac atgaagcata cgcaggacag gggaaccaca 755101 gcttgagcgt ggcggacgtc gacggagacg gaaaggatga aatcatatac ggcgcaatgg 755161 ctgtcgatca tgacggaacc ggcctgtact caacgggcct cgggcacgga gacgcgatgc 755221 atgtagggga tctggacccg tcacgaaaag ggcttgaagt gttccaggtg catgaggacg 755281 ccacgaagcc gtacggactg tcgctgcgag atgccggaac cggtgagata ttatggggcg 755341 tccatgctgg aactgacgtt ggccggggca tggcggctca tattgatcca agctacaaag 755401 gatcgctcgt ctggggaatt gatccgccgg gcaatgatgg catgtcgtac gggcttttca 755461 cgagcaaagg cgaaaaaatc agcgacaaag cgccctcttc agccaatttc gccatctggt 755521 gggacggtga tttggtcaga gaactgcttg atcatgactg ggacggaacg atcggcaggc 755581 caaagattga aaaatgggat gctgaaaacg gctgtctgaa gacgatattt cagccggccg 755641 gcgtgttgtc caacaacggc acgaaaggaa acccggttct tcaggccaac ctgttcggag 755701 actggcggga agaagtgata tggagaacgg aagacagcag cgcgctccgt atctatacaa 755761 caacacatct cacccgccac tgcttttaca cgctgatgca tgatccggtt tacaggctcg 755821 gcatcgcctg gcagaatacc gcctacaacc agccgccgca cacgagcttt tacctcggaa 755881 cgggaatgaa aaaaccgccg aagcccgccc tgtacatagc gggaagcaaa gcggaggcgc 755941 cgctgtagga ggactaaggg ataagacgca aaggctgaac gctacgccaa gatgattaga 756001 gaactggcag gacgaaccaa tgctcaagcg ctgtacgcac cggttttttc aagggaagag 756061 ctatccgtga tggaagctgt ataaaaaacg aggaggaatg aaaaaatggc aaatcatatt 756121 tatcttgccg gcgattcgac tgttcaaacg tatggagaca gcacaaatca agggggctgg 756181 gggcagtttc tcggctcgca tctgccggag catattcaag tgatcaacag agcgatcggg 756241 ggaagaagct cgaaaacatt tgtggaagag ggcaggcttc aggcaatcct cgatgtgatt 756301 gagccggatg attggctgtt cgtgcagatg ggccataatg acgcgtcaaa aaataagccg 756361 gagcgctaca ccgagcccta tactacttat aaacaatatt taaagcagta tatcgcaggc 756421 gcgcgggaaa aaggcgccca tccgcttctc attacccccg tagcccgctt tcattacgaa 756481 aacggcgtgt ttttgaacga ttttcctgat tactgcattg ccatgaagca gacggccgct 756541 gaggagaatg tccagctcat tgatctgatg gagaaaagtc tcgctttctt tactgagaag 756601 ggcgaggaaa aagtgtacac ctattttatg atttcagaag ggattaacga ttacacgcat 756661 tttacaaaaa aaggcgcaaa tgaaatggcg aaacttgtgg caaaaggcat aaaggagctc 756721 ggcctgccat tgacagaatc gatcatcaaa gaaaggtgaa aatgtgatga gaaaactgta 756781 tcatggcgct tgctattatc cggaattatg ggatgaagag acgattcagc aggacattga 756841 catcatgcgt gaagttggcg taaatgttgt gcggatcggc gaatttgcct ggtcagtcat 756901 ggaacctgaa gaaggaaaaa ttgacgtcgg ttttttcaaa gaaatcatcg cccggctgta 756961 tgatagcggg atcgaaacga ttatgtgcac gccgacgcct accccgccga tttggttctc 757021 acatggccgg cccgaacgca tgcatgccaa tgaaaaaaga gagatcatgg ggcatggctc 757081 ccgtcagcat gcctgtacga acaacccgta tttccgaaaa aaagccgcca tcatcaccac 757141 agccatcgcc aaggagcttg gccggctccc ggggctgatc ggatggcagc tagacaatga 757201 gtttaaatgc catgttgcag aatgcatgtg tgagacatgc ttgcgcctat ggcatgactg 757261 gctcaaaaat cgctacgggg taattgagcg cttgaatgaa gcttggggaa ccgatgtgtg 757321 gagcgagacc tatcagacgt ttgagcaagt cccgcagccg ggaccggccc cgtttctgca 757381 tcatgcctct ctacgcacta tgtatcagct gttttcgatg gagatgatcg cttcgtttgc 757441 ggatgaacag gccaaaatca tccgctgcta ttcagatgcg ccgatcacgc ataacggatc 757501 agtcatgttc agcgtggaca atgagcgaat gtttcagaat ctcgattttg cctcctatga 757561 cacgtacgct tcgcaggaaa acgcctctgc ctttttattg aactgtgatt tatggagaaa 757621 tctgaaacaa gggcgcccgt tttggatttt ggaaacgagt ccgtcgtatg ccgcctcgct 757681 tgaaagctcc gcttacccgc acgcagacgg gtatttgcag gccgaagccg tatcgtccta 757741 cgccttaggg agccaggggt tttgctactg gctatggcga cagcagcgtt caggcagcga 757801 gatttcccac ggttcggttc tcagtgcctg gggcgaaccc accatcggct atcaaaatgt 757861 gctggcggtt gagcgggcaa gaaaggaaat cgagcctatt attctatcga ctgaacccgt 757921 tcaagccgag gcggcgatga cttactctga cagagcaaaa gcatttatta aaactgagcc 757981 tcaccgggga ctccggcatc gttcgcttgt gacgcatttt tatgaacgta ttctcaacac 758041 ggggattcac cgtgacctta ttccggaagg cgctccactg gacggctatc gcttgctgtt 758101 tacgccattt gtgccgtatt tgtcttctga atttatcaaa aaagcttcgg cattcgctga 758161 agcgggcggc atctggatca ccgggccgct gacaggagga cgcacatgcg agcataccat 758221 tcataccgat tgcggacttg gcgaacttga gaaaacgtca gggatcaaaa cactttttac 758281 ctttccgatg aatgagaacg tgaatacagg aaaagcgttt ggcatcacgg cgccgctcgg 758341 actgtggagc gcggtgtttg acacagagag cggaaacacc cttggcacgg ttgaagcagg 758401 accgggggcg ggccatgctt ttctgacgga acggaattac ggcgagggga aaattgtcat 758461 gctgggctcg cttccatccg ggaaagaagg ggatgcgatg ctggaagcgc tcgtcaggca 758521 ttatgcggag gaagctgtta tttccagccg gtcggatgtg acacccggca cgatcgttgc 758581 cccgcgtata ggcgaaaacg gccttgtgtg gatcgttgtg aatatggatg gaaaaggcgg 758641 gagcgtgaca ttgccggaat cgggaacgga tttgttgacg caccgcttgg aaaaggcggg 758701 gagactggcg gtcggaccgc atgaataccg tgtgattcaa tttgacaatc acagctgatt 758761 ctttgtatcg aatcagcttt tttctatgga gggagagaca gatgaaaaag atcaaatggt 758821 tatcaggaca gccaaaggtg acaagcggcg tgacgtgggg catgccatgg aaaaaaggag 758881 aattaaaaaa aggagaccgt ctggcgctta tgaatgaaaa cgcggaaacg cgatatgtgc 758941 aaagcgaacc gtcggcctat tggccggacg ggagcatcaa gtggacgaag cacgcggcgg 759001 tgtttggcgg tcaggaaaac caaagcttta cagtgcacaa aagagaagtg ccgcagccaa 759061 ctgaatcgct cagcattctt gagacagagc atgatatcca agtggataca ggagcactcg 759121 tttgtaccat tcataaaaca ggatctgatt tcattcaatc attgcagatc aatggaaagc 759181 cgatcgccgc aggcgggagg ctcgttgcga taagagaaac gagaaaagag tcagcggcga 759241 aaatggttct tttgcatgaa aggtctgtca gctttatcaa acgggcggcg attgagcaga 759301 gtggtcctgt caaagcagta gtcaaaatcg agggagtgca tgtgcttcat aaaacgtatg 759361 aggaatggct gccgtttgtc atccgattaa cgttttatgc cgggctgtct gagatcggcc 759421 ttgtgcacac gcagctgatt gacaggagcg gtaaactaga attcgttaag gggctcggca 759481 tcgaattcga cctttttttg gagggagagc cgtacaaccg ccatttccgc tttgcgggag 759541 agaaagggat gtataaagaa cccgcccagc tgtttggcac acgtaaattc aatgaacgat 759601 atccgcttta tgaaaaacaa atcaatggcg aaatgctgtc tccagatgaa gagcataagg 759661 aatggtttgc acatggcaca cagaatgcgg tttgggacga tgtcaagatc gtgcaagatt 759721 ccagcgatca ttacagcctg tcaaaacgga ccggaaaaga ttatgcgtgg gttggaatgc 759781 tgcatggcag ccgggcgaag gggctctgct atgcgggcgg aaaaaatggc ggtgtggctc 759841 tcggcctgcg gtatttcttt gagaaatatc cttcagcact ggaaatcaca ggtcttgccg 759901 gcagccgccc caaaatgact atctggcttt ggcctccgga cggcgaagcg atggatttgc 759961 ggcattatac aggaaacact cacgtggcca gcgcgtatga aggctttgat gaaatgcgct 760021 ctgatccgac aggcattgcg aacacaaatg aaataagcct ggcgtgcttt tcgcacatgc 760081 cgtctgacga agtcctcaat gcgctggctg acaaatggca ggcgcccccg ctcattgtat 760141 gcgagccgga cgtctattac gaatcaaaag cactcggggt atggagcatc attgacacat 760201 cccatccgct caaaaaagag ctggaagaac agcttgatgc ggcctttctg ttttataaaa 760261 aggaagtaga gcaacgcaga tggtacggtt tttggcatta tggcgatgtc atgcatacgt 760321 atgacccgat ccggcatatg tggcggtacg atctcggcgg atacgcatgg caaaacaatg 760381 agctcgttcc gaccctatgg ctgtggcagg cgtttttccg ctcaggcaga gaggatatct 760441 tccgaatggc agaagccatg acccgccata cgagtgaaac ggacagcttt cacctcggtg 760501 aatatgccgg gcttggctca cggcataatg ttgtgcactg gggatgcggc tgcaaggaag 760561 cgagaatcag catggccggg cttcataaat tctattatta tctgacgggt gatgaccgga 760621 cgggagatct tttgacagaa gtgaaggatg ccgattatgc ccttgtcaaa accgatccga 760681 tgcgcgcttt ttacgagaaa ggcaagcacc cgactcacgc cagaacggga ccggactggg 760741 cggcgttttg ctcgaactgg ctggcggaat gggagcggac cgaaaattcg gaatatctca 760801 aaaaaatcga aacgggaatc aactgtctga agcggctgcc gctccgctta ttatctggcc 760861 cgacatttga atatgatccg gcgacctcga tgcttcatca tatgggagac ggcattgcgg 760921 gcggatatca tatgatcatt gccttcggcg cgccgcaagt gtggatggag ctggctgagc 760981 ttcttgatga ctgggaatgg gaggatatgc tgagtgaatt cggcgaattt tacacactca 761041 gtgatgagga aaaacgaaaa aaaagcggag gcgctcttca tgacgggcat tttcactggc 761101 cgatgttcgc cgccggtatg acagcctacg ccgcaagaaa aaagcaagat cctcatctcg 761161 ccgccaaagc gtggaatctt ttgctagaag ataagctcag ccatacgccg cttccgatca 761221 aaccggagcg catcgagaca tggacgcagc tagaggagct tccatgggtg acaacgaaca 761281 ctgtctctca atggtgttta aatgtcatag cggcgctgga actgatcgga gattcccttc 761341 cggcaaaaaa agaaacatcg ggcaaaaaag gataacagcc ggaatttcat aggagaaatg 761401 gtgcaaaaaa tgaagattgc aagaatttat gtaagcgctt tatattgaga ggggcaaagg 761461 ggaaatgcaa attgaaaaaa gggggactta cgcaacatga aaataagaat gcgaaaaaaa 761521 tggatggcct tgccgcttgc tgccatgatg atcgccggat gcagccattc ggaaacatcc 761581 aattcagcaa gcggttcgaa agatacgatc aaaattatgg cgccgctctt atcgccggaa 761641 agcccaagtg ataagagccc ttcattaaaa gcgctcgaaa aatacacagg caaagagatt 761701 aaggtcacat gggtgcctga ttcatcctac aacgacaaat tcaacatcgt catggcttca 761761 ggagagatgc ctcacgcgat tgtcattaaa gataagtcag ccggctttat caaatctgtc 761821 aaagcagggg cgttttggga gctgtctcct tatttaaaag actacaagaa tttaagccag 761881 gcagatgaaa agattttgaa gaacagctcg gtgaacggcg aggtgtacgg aatctacaga 761941 acgagggatc tgatcagggc gtgtatgatc atcagaaccg actggctgaa aaatgtcggt 762001 ctggatatgc cggaaacgct tgatgatttc tatgaagtgc tgaaagcctt taaggaaaaa 762061 gatcctgacg gaaacggcaa ggatgatacg tacggcatgg tcgtgccgaa atggatggga 762121 ctcggcaacg gaagcccatg ggatgttctg caaatctggt tcggcgctcc gaaccgctac 762181 ggtgttgaaa acggaaagct gattccagat tttacaacga aggaatacat ggatgcgctc 762241 acgtttttta aaaagctcta tgatgagggc ttgatcaata aggactttgc tgtcatggat 762301 tctgcgaagt ggaatgatcc ggttgtaaaa ggaaaagcgg gtgtcatcgt tgatacaggc 762361 tcaagagcgt ctcaaatcca aagcgcgatg gaggaggcgg atgagtcgaa caaggatatc 762421 attgatatcg tcggctcgct tgagggaccg aatggcaagc gcaccttccc gacatctggt 762481 tattcaggca tgatcacgat accaaaatca agcgtcaaaa ccgaaaaaga gctgaaagag 762541 gtgctgtcct tcctcgataa gatgaatgat aaggaagcgc agattctcac gaacaacgga 762601 gtgaagggcc gcaattacga gctcaaggac ggcgtattca cctcacttga aaaaaacaat 762661 aaatctctcc tgtatgagca tgaaggcttg gcacagttca gcatgtcgat tccgaaaagc 762721 gagtattaca tcgaagacca gaaaaccaag ctcttccagc atcgcaagga catcataacc 762781 gaaggagaaa aaatagccgt ctttaaccct gctgagtcgc ttgtatctga tgtctatacc 762841 caaaaaggag cccagcttga caacatcatc ctcgacgcga gaacacaatt tatcattgga 762901 gaaattgatg aaaaagggtt cgatgatgcg gtggagcttt ggaaaaaaag cggcggcaat 762961 gaactgatga aggacttgaa caaattgtac caatcgtcaa aataaaccga tgcgcctgcc 763021 tttcggcggg cgccccggta tcacgaaagg agaacagata tggaaacagt gccgaagaag 763081 agagatgcac ctgttctcac cgctggaaaa ggcatcagct ggatggctgc gctcaaacgg 763141 gacaaatggc tttatcttct tcttattccc ggtctgcttt atttcttgat tttcaaatac 763201 ttgccgatgt ggggtgtgct gatcgctttt aaagactatt cgccatatct cggcttctgg 763261 aaaagcgaat gggtcggctt tgattatttc aaagactttt ttatgaatcc ggattttttc 763321 cggctgctgc gcaacaccct catgctggcg agtctggatc ttttgtttgc ctttcccgcg 763381 cctctcattt tggctctgct tttgaatgag gtaagaaagg ccgtgtataa aagatgtatc 763441 caaaccttta tttacgtacc ccattttgta tcatggacaa ttgtggtcag catcaccttc 763501 gttttcttta ctgtcgatac aggtgtgatc aacaaattga ttatgagcct gacaggtgag 763561 cagatttctt tcttgtcgga tgcagactgg ttccggccaa tgattgtgat gcaaagcatt 763621 tggaaggaga caggctgggg aacgattcta tttttggcag cgcttgctac ggttgatcaa 763681 gagcagtatg aagcggccat catggacgga gcggggcggt tcaggagaat gtggcatatt 763741 acgctgccgg cgattagaag caccattatc gttttgttga ttttaagaat cggcagcttt 763801 ttgaatcttg gctttgaaca ggtgtatttg atgacgaact cactcaaccg cagtgtggct 763861 gacatcttcg acacgtatgt gtacatgatg gggattaccc aaggggcgta tagctacagc 763921 acggcggtcg gtttgtttaa atcagttgtc gggattatct tgatttttgg cgccaattac 763981 attgcgaaaa agtttgatca ggaaggattg ttttagagga gggagaggta tggctgaaat 764041 tcacacgatg cacaacacca aagccggacg ggtgtttgac gtctgcaaca ttctgtttct 764101 cggcggtgtc ggcgcgatta ccattttgcc gtttttatat attatcgccg gttcctttgc 764161 gacagaagcg gaactcgccc agcggagctt ctttattttc ccgaaaacct ttacacttga 764221 tgcttacaag tatgtgtttt cgacaccgac gttccttcga agcatgggcg tgtccatctt 764281 catcacggtg gttgggacgg ctgtacagct gttttttacc ttcacgatgg cgtatccgct 764341 ggcgaaacgg catgtgaagg gacggaatct gctgttgaat ctggtgattt tctccatgct 764401 gttttcaggc ggcatgattc cgacgtacct tgtcgtaaaa tcacttggcc ttttggatac 764461 gtattgggca ttgattctgc cgatggcgat taatccgttc aaccttatta ttatcaaaaa 764521 cttctttcag cagctgccgc gcgagctgga ggaatcagca aaaattgacg gctgttccga 764581 aatcggcgtc ttctggcgga tcgccctgcc tctgtcaaag ccagttattg cgacctttgc 764641 gctgttttat gcggtcggga tttggaatga tttcttccac gctctcttat atatcaatga 764701 cagtgcaaaa tggccgctgc aaatggtgct tcgccaagtc acaattttat cggatttaac 764761 ggcgaccaat ggtgatacga tgcaaaatgc agttccgccg gagcagggaa ttaaactcgc 764821 tgtcattgtc attgcgacgc tgccgatttt ggcggtctat ccatttttac aaaaacactt 764881 tgcaaaagga atgctgatcg gttcggtgaa aggctgagaa agggagtgtt tcatatcagt 764941 acattagatc agattaagat tgcctatatc ggcggggggt cccaaggctg ggccagaagc 765001 ctgatgagtg atttgtcgat tgatgaacgg atgtcaggca cggtggcgct ctatgatctt 765061 gattttgaag ccgctcagaa aaatgaagtg atcggcaatc acagcgggaa cggcagatgg 765121 agatatgagg ctgtttctac tttgaaaaag gcgttatcag ccgcggatat cgtcattatt 765181 tccattttgc cgggatcact ggatgatatg gaagtcgatg tgcacttgcc tgagcgctgc 765241 ggtatttatc agtctgtagg tgatactgtc gggcctggag ggatcatcag gggcttgcgt 765301 gctgtgccga tatttgcgga aattgcccgg gcaataagag actacgcacc tgaatcatgg 765361 gtcattaatt atacaaaccc gatgtctgtc tgtacaagag tgctgtataa agtgtttccc 765421 ggcatcaaag cgattggctg ctgccacgag gtattcggga cgcaaaagct attggcggaa 765481 atggtcacgg aaaggctggg gattgaggtg ccgcggcgtg aggatatccg cgttaatgtg 765541 ctcggcatta accattttac atggatcaca aaagcctctt accgccatat tgacctgttg 765601 cctatattcc gtgaattcag cgcgcactat ggggaatcag gatatgagct ggagggggaa 765661 tgctggaggg acagcgtctt ttgttcggca caccgtgttg cgtttgattt atttgaaacg 765721 tatggcgcca tccctgctgc gggtgacagg catctggcag agtttcttcc cggcccatac 765781 ctcaaacagc ctgaagtatg gaaatttcat ctcacaccta tatcattcag aaaacaagac 765841 agagctgaga aacgacaaga aacagaacgg ttgatcgtgc aacaacgggg cgttgctgag 765901 aaagcttcgg gagaagaagg cgtgaacatc atagcggctc ttctcggatt gggtgaactc 765961 gtcacaaatg taaatatgcc gaatcaaggc caggtcttaa accttcctat acaagccatt 766021 gtcgaaacaa acgcattcat cacaaggaac cgtgtccagc cgattttgtc cggagcgctt 766081 ccgaaaggtg tggaaatgct ggcggctagg catatatcca atcaggaggc agtggcggac 766141 gcaggtttaa caaaggatac tggcctcgcg tttcaagcct tcctcaatga cccgcttgtc 766201 cagattgacc gcagtgatgc agagcagctt ttcaatgaca tgctccaatg catcatgcaa 766261 agctgagctt gccgattagc tctttccggt ttagaaagga aagcattgac catactgata 766321 gtataatcaa gaagtaggtg ctatcaatat gggaaattat ttaagtgttg cggtagaact 766381 ggtctgcggt ttaggcattt tatttatcat cttaaagctt ctcgggaaaa cccaattttc 766441 tcaaattacg ccgtttgact ttatttctgc tttaatttta ggtgaattgg tcggaaatgc 766501 cgtctacgat catgaaatca aaatcaaaga aattattttt gcttcgctat tgtggggcgt 766561 gctgatttat attattgaat ttatcacgca aaaaatgaaa tcatcgcgaa agttcttgga 766621 gggcgagccg aatatcgtca tccgcaaagg ggagcttcaa tataaagtaa tgaagaaaaa 766681 taagatagac attaaccagc tgcaaagcct attgaggcaa gctgggagct tttcgatcca 766741 agaagtagaa tatgcgattc ttgaaacaaa cgggatggtc agcgtgcttc caaaatcaga 766801 ctttgacaaa ccgacaaata aggatttgca gattccttcg aagtccgttt ctctgccgat 766861 cacgttaatc atagatggag agattgtgcg ggataatttg aaggaagcag gtgtggatga 766921 acagtggctg aaacaagaat tgaaaaagaa gaacattgat aagacagagg acgtgttatt 766981 tgcagaatgg cataaaaata agccgctgta tactgtaacg tacgaacaaa gcagatcaac 767041 atgactctta gaaaaaagct tgcagcaagg cgcaagcttt ttattgattg tatgtccctt 767101 gtttgacagc acgtacatgg tacatgctca cttcagtgct gatcagatag tcaggctttg 767161 gtttgccttt gtttgcttta tggccggcga tatgcgcatc gcttttttcc cattgcttcc 767221 agtgatcctc tgattcccag cgaatcatga caacaacttc ttcatcaccg cggcgcacat 767281 ttttctcaag cactgtcaca tcaattaaac cttcttgttt ttcaatgatt ccttcagcgc 767341 tgaaacgttc tatgacttta tctgcaaagc cttctttaac cgtcattttt ctcaactgta 767401 caaacatttg tctcactcca atcattctca catatgaata attgtaaatg aaattcattc 767461 tcaatgtcaa agaaagcgca gggcggaatc gaaccgccgt gcgcaacagt ttattctttt 767521 aataaaaaca catttccgtc ttcgtcctta aattgaacga aggtgcccca ctccatttga 767581 ttgggctcac cgagaaattc tacaccgttt gtcttcattt tctcgtatgt accaaagatg 767641 tcttcgcatt caaacacaat agaagccttc atttgctctg agcctttcat catggctttc 767701 gggtaaatga ctaaacgagt ctcggctcct tttggcgcaa cctccagcca gcttgcttca 767761 ggtcccattg ggtgatccgc tgcaatatca aagcctacct tctctgtcca aaattgcttc 767821 gctttctgct ggtcctcgac atatacagca acagtgccaa tttgtttgat catagggaaa 767881 cctccaagtt gaaaagataa taatactata acctgtttac ggccgaagta acataaaaaa 767941 atcagccggg aaaccggctg attattaaaa tgagcagctt acaacatcga tgtgatttgt 768001 gtctaaggcg aaataaaccc agcggcgccg tgaggaatcc caataaaagc cgccgacgga 768061 tcttctgcca aggatgatcg ggtaaaacca aaatgagcgg ccattggtta accagacata 768121 ggtaaatcgg aaaaggcaag gacgaatggt gattggttca actaacaaaa cggctccttg 768181 agaaccctgc ggttttgggg gtttcgctgg tatttgggaa ggaggaggtc cctgcggcgc 768241 accgccgaag cctgggctgg caccgctgcc aataccaggg ccggagccgc cgccaaagcc 768301 tggaacagca ccaccgccaa tgccaggacc ggagccgccg ccagagcccg gaacagcgcc 768361 gctgccaatg ccaggccatg gatatcggta ttcatattca aaagcaggcc aaggctcata 768421 aaaatgcccc gcaaacatat aaggatcaac ataatacatg tgataacgtc ctttctcatt 768481 gtaaactgta cattgcagtt tatgcgggcg gactcttatt ggtgcattcg cctaaggata 768541 tgaagctgga atgctctcag agagcagaat catttgattt ttctctagtc ttattcacaa 768601 ttccgattta tcattttata atgaaagtgc ttctattacg aaaaaggaga cagaccgtga 768661 atatcgatca attattatat caatatatca tagacaacac tgcggatatt actgagaaat 768721 ggttcagttt gcgttgccag ctaaaaggcg agctatattc cgccagccat ttaagtgaag 768781 aaacgaaaac acttttaacc gagcagcata catttaccaa tataacaatc gcaagcgcat 768841 ttctggagga tcaaaccgat tttcaagaaa acatgacaaa atgggcgcaa aacgttgcga 768901 aaaacagggt agagcaggat gttcaagtgc atgaggtcgt agaagccata tccaattcaa 768961 gaatctcatt ctgggacgca gtcgccacat ttataaaaga gaatcaggag attgtgacaa 769021 atgaggatgc agaccgatgg aaccgcattg tgaatcagtc gttcgataag ctgattattg 769081 aattctccga gcagtaccaa aaattcatgc tgatgaggct tacatctcag caggaactga 769141 tctcagagct tggctgcccg gtcatttcca ttgccgatgg aatcgggata ttgccgctta 769201 tcggctccat tgatacaaaa cggcacaggt cattttagaa acagtgccgg tccgctgtgt 769261 cgagagaaaa atcacaagcc tcgtcgttga tctttcgggt gttccgattg tggataccat 769321 ggtggctcag caattgtaca acctgtctaa aacacttttc ttattaggcg tcaaagccgt 769381 attttcagga attcgcccgg atgtggccca aacatcgatt caattggggc ttgattttag 769441 tgaatatgaa acgtacggca cgctgaagca ggcattagaa aacatgggtg tccgctgtat 769501 tgttgaggaa ttggaagaaa acaaatagga agtttccagg catatgattg tccgtcaccg 769561 ggtgatcata tgcctttttg atttgaacag aaatcaccat tgatttatcg aaaaaaacat 769621 aatattataa ttcttataag aatactgtga attaaaacct attcaacagg ggggaaggtc 769681 ttttggtttc taaatcaacg attgatccgg aagtgattga aaaaatcatc agctcgctgg 769741 aaacactcga tttcggcacg gttcagatta cggttcatga ttctcagatt acccaaattg 769801 agaaaataga aaagcaccgt ttttcgctga aaaggaaaga atcaaaatga taatgtaaag 769861 ggcgtttgtt ttcattaaat tctccttaaa acatatacat atttcatcca atttttatat 769921 aatagacctt taagatcatt ttttaggagg atttttgaca tgcaagctac ggttcacgag 769981 agtaagcaat cgatcatgca acgcattttg acagtctttg tcttcacatt gctgatcgcg 770041 actgtcggcc tttttatcgg ccaatttgtt cctgtcgctt tgatgctgcc gctttctatt 770101 cttgaagtgg cgatgattat tctggccttc tggatgcgca gaagaaaagc ggtcgggtat 770161 gcgtttgtat atacattcgc gttcgtttcc ggcattacct tatttccgat cgtcagccat 770221 tacgcttcca tcgccggcgc ctatgtcgtg ctcgaagcct ttggctctac atttgtcatt 770281 tttgccgtct tgggcacaat cggcgcaaaa atgaagaagg atttatcctt cctgtggtcg 770341 tttctgctgg ttgcggtgct cgcactcgca gtggtaggga ttttcaacat tttcagcccg 770401 ttaaactcag cggcgatgat ggcgtattcc gtgatcggaa ccatcgtctt ttccctttac 770461 attttgtatg atttgaacca aatcaagcac cgccacatta cggaagactt gattccggtt 770521 atggcgttat cgctgtacct agactttatc aacttgttca tcaacctgct ccgcttcttc 770581 ggcattttga gcagtgatga ttaatgaaaa agcgtctgtc attggatagg cgctttttgc 770641 catacatcaa aaaggcaggt ggagtattgg tgaaaaaaca aatgggcgca tatgtatctc 770701 tggcagcagc tatggcgatc gtcggcagtt ctgtcgttgt cggcaagctg atggtcgaac 770761 ggattccggt ctttctttcc tcaggattgc gttttttgat cgcttctgtc gtattgctca 770821 tgctgctgtt ttgcattgaa aaagggtttc cggctttgac gaaaaaagat gtgttcgtat 770881 tactggtgca atcattcaca ggcgtgtttt tgttcagtat ttgcctgctg tatggggttc 770941 aatatacgac gggaacggaa agcggcattt tgacaagcac aacccccatg ttgatcggta 771001 ttttatcctt tttcctgctg agagaaaaaa ttgagaaaaa gacgctgatc ggcattttgc 771061 tggcggtttg cggcgtaatg gcgattaatt tgtttggagc cgggagccaa gacgggacgc 771121 cgcacgcctt attcgggaac atgctgatca ttgctgcagt cattggcgaa gcgttgttta 771181 cattgatggc caagctgcta tccccgcata tttcggcact ggcgatttcg accttcgtat 771241 cgctcttcgg cttcctgttt tttctcccgt ttgctttgtt tgaggcctct tcatttgatt 771301 acagcgtgcc gactgttttg gattggtcgt atgtgctgta ttacgcgctt tttgtcactg 771361 ttttggcgtt ttacttatgg tatagcgggg tgacgaaggt gccggcgggt gtatcgggca 771421 ttttcacatc cgttcttccg gtctcagctg tcattttgtc aggcgtgata ttgaaggagc 771481 catttgagtt tgtgcatttc atcggcattg catgtgtcat cggcggcata tttgttacgg 771541 tcataaagaa aaaacagccg gatgcgtatc cggctgcaga agaaaagacg ctatagcctg 771601 tccggatcgg acgggttttt tagtctttaa acacgctcag cctttcaaaa agatcaccaa 771661 gcatcttcac gaacatgtct ttttcctcgt cgctgtagtt ttccatgaca gcggatattt 771721 tgctgaaatg gccgggcaga aattgctcca ggcgtgcttt gccttctgtt gtcagttcaa 771781 tgctgatttt tcgtttatcc tctgtgtgat gcctgcggct gacaaaaccg tctctcgcca 771841 gcccgtctag caggcctgta attgttgctt tcgtgacatt tgaccgcttg gcaagctctg 771901 tcggacttaa cctatgatcc ttggcatcaa agagcagcat caggattttg aattttcctt 771961 ctgaaagccc tcggccagca aagtaatgct ccatcacatg attcattttt tttgaaatat 772021 caaaaagaga taaaaacaat tcaagagagc cggcgtcaat attggcatac gtttcggcgt 772081 gctctgttat atgcttatat ttcggtaaat gttttaattc catcgcaatt agctcccgta 772141 cattcgttgt gacacgatta taaaggaggg aaaaccataa cgcaacttgg cttggagatg 772201 attgacagct tttcttggga catagtaagg taatatagtt aggcgcctaa ctaatacata 772261 tagagctgaa aaggtggtta ttgatatgaa acatatgtta atagcaggag gcggaatcgg 772321 cggcttgtca gcggccattt ctctccgtaa ggcagggttt tccgtcacct tatgtgaagc 772381 ggcttcagaa aatcgaaaaa caggtgcggg gattcttcag ccgcaaaacg cactggcggt 772441 gttgaaagaa ctgggcgtat tcgaagattg ctgtaagcac ggctttcaaa cagaatggtt 772501 taaaacgttt gatgaacagg ggaatttgct gtttcaagtc agtgaatcct ttttagacga 772561 ttcacttccg ggacgcaata atatcctgcg caaaacgtta aatgacattc tcatgaagca 772621 tgccgaggca gtgggtgtag acatcaagtg ggggaaaaag gttgtcgcct atgaagaaac 772681 tgctgaatcg gtcactgcct tatgtgaaga tggagaaaag atgcaggctg acattctggc 772741 gggctttgac ggcattcact ccgttgttcg tgataagatg ctgcaaaagg aaacggaaaa 772801 agagcatctc ggcatgggag cgtggcgctt ttatatcgaa cttcctgatt acacattcga 772861 ggacgcaaca ttcatgtata gaagcggaga cacacaaatc ggggtggtgc cattggcaca 772921 acacgctggc tatgtcttcg tcctccagcc ttgcacgagc gattactggg atgaggaaga 772981 tacccggttt gatagagtaa aagagattct ttctggtttt cgggggctgg attttgtcac 773041 aaagcacatg tcaaaacagc atcctgtcat ctttaacaaa ctggagcagg tcgccgtgca 773101 ggagccatgg cataaaggcc gcgtcatcat cggaggagac gccgcccacg ccggtgcgcc 773161 aaccctggca caaggagcgg caatggcgat cgaggatgcc atcgtcctcg ccgaagaact 773221 ccaaaaccac gccgaccacg aaacagcatt acaggcgtac tataaaagaa gagccccacg 773281 agcgctcaaa gtccagaacc tatcatctga aatcgtccgc cgcaggctga aaggagagcc 773341 gggagcggaa gaactgattg gggagtgcta tgcggtgttg agggaagggt attaaatagg 773401 aaaagtccag aaagtgattt ctggactttt tagtcttgct ctgttttatt ccttatccgc 773461 tcaatcacct catgcagccc ctcaggctta taaaactcca ccggtgaact gcctttctca 773521 aacgaaatcg tctcggcttc aatcagcgcg acatagcgcc cgtttacttt tgcgagatga 773581 atagaatcgc caaaatccgc tagcaatccc ttaatctctg tttctccgac tttcattttc 773641 agctgggcct ctggcgtgtg ctcgatgatt tgggcggagg cttcgatgac ttgatgggtg 773701 tcgaggcgct cttggatttc ccgtttttcg cttgcttccc aaatctcaat gtcgtgctcg 773761 aactgcttga gttcttcgct gttgtcttca aatgtctcgt agacgtgctc ttgtaccatg 773821 ttcatgacct gatttttcat gatttctggc atcgattctc cgtactcgac gaatttcaga 773881 aagtcctcaa aatagcgggc gtgcgaggcc tggtggattt tcagttcacc ttcctcgacc 773941 attccttcct ctggcatgta cgggtattgg atgcttttca tgttttttgt cgtgatcgcc 774001 atttcgactt ttttaatgag agaagacgcg tcagagatgc gggcgacctt cggctcaaaa 774061 tcacatttca taatgaagac aaatgactca tcaaagtatt ttctcggcac ggccgaagcg 774121 acgagaaaca cgccgccgcg aaccgcgctt gtgtcaaggt acgtgcggac gaactgctcg 774181 ctcagctcat tgaagtcttc ttttgtttcc gccagacgcg cgcggttgaa catgttgtag 774241 tttgggttgg aatcgagctc gtggccgggc tcgacgataa aatggccgat tttcgtcggc 774301 acctgctcgg actgcggatg gcggtcggct ttccgtttaa cgattttttt cagttccccg 774361 tcgagaaagt ccttcagctc gctttcttca aattctcccg tatcaagggt ctggaagtgc 774421 ttgaactgct tgttcgcctg ctcatctttg ccttccacct gtatgacata aaaggataaa 774481 aaccgaattt caaaatccat atataaactc accttattcg cgtattgtac agcttctcaa 774541 gtatagaaaa aacagcgatc atgcgtcaat tgggagaacg gaataatcat gaccatgaaa 774601 gggaaatgta gtcaaataga aggcatttca tacggaaagg aatggttcga tgaaggaaac 774661 aagcccgatt cctcagccga agacgtttgg gccgctcggc aatttgcctt taattgataa 774721 agacaaaccg acgctttcgc tgatcaaact ggcggaagaa cagggcccga tttttcaaat 774781 ccatacaccc gcgggcacga ccattgtagt gtccggccat gaattggtga aagaggtttg 774841 tgatgaagaa cggtttgata aaagcattga aggcgccttg gaaaaggttc gcgcattttc 774901 cggtgacgga ttgtttacga gctggacgca tgagcctaac tggagaaaag cgcacaacat 774961 tctgatgccg acgttcagcc agcgggccat gaaggactat catgagaaaa tggtcgatat 775021 cgctgttcag ctcattcaaa aatgggcaag gctcaacccg aatgaagcag tcgatgtccc 775081 gggagatatg acccggctga cgctcgacac cattgggcta tgcgggttta actaccgctt 775141 taacagttac tacagagaaa cgccccaccc gtttatcaac agcatggtgc gggcgcttga 775201 tgaagcgatg catcaaatgc agcggcttga tgttcaagat aagcttatgg tcagaacaaa 775261 gcggcaattc cgctatgata ttcaaacgat gttttcgtta gtcgacagca ttattgcaga 775321 gcgcagggcg aatggagacc aggatgaaaa agatttgctc gcccgcatgc tgaatgtgga 775381 agatccggaa actggtgaaa agctcgacga cgaaaatatc cgctttcaga tcatcacgtt 775441 tttgattgcc ggccatgaaa caacgagcgg cctgctttcc tttgcgactt actttttatt 775501 gaagcatcct gacaaactga aaaaggcgta tgaagaggtc gatcgggtgc tgacggatgc 775561 agcgccgacc tataaacaag tgctggagct tacatacata cggatgattt taaatgaatc 775621 actgcgctta tggccgacag ctccggcttt cagcctttat ccaaaagaag acacagtcat 775681 tggcggaaaa tttccgatca cgacgaatga cagaatttct gtgctgattc cgcagcttca 775741 tcgtgatcga gacgcttggg gaaaggacgc agaagaattc cggccggaac ggtttgagca 775801 tcaggaccaa gtgcctcatc atgcgtacaa accattcgga aatggacaac gggcctgtat 775861 cggcatgcag tttgcccttc atgaagccac acttgtgtta ggcatgattc taaaatattt 775921 cacattgatt gatcatgaga attatgagct tgatatcaaa caaaccttaa cacttaagcc 775981 gggcgatttt cacatcagtg ttcaaagccg tcatcaggaa gccattcatg cagacgtcca 776041 ggcagctgaa aaagccgcgc ctgatgagca aaaggagaaa acggaagcaa agggtgcatc 776101 ggtcatcggt cttaacaacc gcccgcttct cgtgctgtac ggctcagata ccggcaccgc 776161 agaaggcgtc gcccgggagc ttgctgatac tgccagtctt cacggcgtaa ggacaaagac 776221 agcacctctg aacgaccgga ttggaaagct gccgaaagag ggagcggttg tcattgtgac 776281 ctcgtcttat aatggaaagc cgccaagcaa tgccggacaa ttcgtgcagt ggcttcaaga 776341 aatcaaaccg ggtgagcttg agggcgtcca ttacgcggta tttggctgcg gcgaccacaa 776401 ctgggcgagc acgtatcaat acgtgccgag attcattgat gagcagcttg cggagaaagg 776461 cgcgactcgg ttttctgcgc gcggggaagg ggatgtgagc ggtgattttg aagggcagct 776521 tgacgagtgg aaaaaaagca tgtgggcgga tgccatcaaa gcattcggac ttgagcttaa 776581 tgaaaacgct gataaggaac gaagcacgct gagccttcag tttgtcagag ggctgggcga 776641 gtctccgctc gctagatcgt acgaagcctc tcacgcatcc attgccgaaa atcgtgaact 776701 ccagtccgca gacagcgatc gaagcactcg ccatatcgaa attgcattgc cgccggatgt 776761 tgaatatcaa gagggcgacc atcttggcgt attgccaaaa aacagccaaa ccaatgtcag 776821 ccggattctt cacagattcg gtctgaaggg aaccgaccaa gtgacattgt cggcaagcgg 776881 ccgcagtgcg gggcatctgc cattgggccg tcctgtcagc ctgcatgatc ttctcagcta 776941 cagcgtcgag gtgcaggaag cagccacaag agcgcaaata cgtgaactgg cgtcatttac 777001 agtgtgtccg ccgcataggc gcgaattaga agaactgtca gcagagggtg tttatcagga 777061 gcaaatattg aaaaaacgaa tttccatgct ggatctgctt gaaaagtatg aagcgtgtga 777121 catgccgttt gaacgatttt tagagctttt acggccgtta aaaccgagat actattcgat 777181 ttcaagctct ccaagagtga atccgcggca agcatcgatc acagtcggtg tcgtgcgcgg 777241 cccggcgtgg agcggccgtg gcgaatacag gggtgtggca tcaaatgatt tagctgagcg 777301 tcaagccggt gatgatgtcg tgatgtttat ccgcacaccg gaatcccggt ttcagcttcc 777361 gaaagaccct gaaacgccaa ttattatggt cgggccaggc acgggagtcg cgccatttcg 777421 cggtttcctt caagcccgcg atgttttaaa gcgggagggc aaaacgctcg gtgaggctca 777481 tctctatttt ggatgcagga acgatcggga ttttatttac cgagatgagc ttgagcggtt 777541 tgaaaaagac ggaatcgtca ctgtccacac agccttttcc cgaaaagagg gcatgccgaa 777601 aacatatgtc cagcatctca tggctgacca agcagataca ttaatatcaa tccttgaccg 777661 cggtggcagg ctttatgtat gcggtgatgg cagcaaaatg gccccggatg tggaggcggc 777721 acttcaaaaa gcgtatcagg ctgtccatgg aaccggggaa caagaagcgc aaaactggct 777781 gagacatctg caggataccg gtatgtacgc taaggatgtc tgggcaggga tatagataaa 777841 gaagactgga gacatccagt ctttttagtc ctttcgaaaa aatggtgatc gcgctaaaca 777901 ttgatgcata caataacttc agtccgccgg aagggcgggc tgtctgcaaa acctattttt 777961 cgtttttgct agtttatgtt attcttatac tcggtatcta tttctttttt caaaggcaca 778021 catgacaaaa gaaatccttt ttttatttcc gagaaaaaaa tgtgaaacga aatgaaggtt 778081 tctttcgtcc agtgattggt ttccaaatgg ttgtaataaa aatgatatgg tgcgaaacat 778141 aaatattccg gcttgccgcg gtgtatttat tgttgtgtga tgccttgatt ttgtttggaa 778201 agaaggaatt ggaaggcagg atataaagag caggtaaata tgaatgaaga acttaaagtg 778261 tttaagaaag tagaggttgc catgaagaaa cttttttctt acaaacttag cttttttgtg 778321 ctggctgtta tactgttttg ggcaaaaacg tatttatcct acaagactga gtttaatctt 778381 ggggtaaaag gcacaactca ggagatcctc ctgatattta acccattctc aagcgccgtc 778441 ttctttttag gactggcttt gctggcgaaa gggcgtaaat cagccattat tatgctgatt 778501 atcgatttct tgatgacatt tgtgttatat gcaaatattt tattctatcg tttctttgac 778561 gatttcttga cgttcccgaa cattaaacag tccggaaacg ttggaaacat gggagacggg 778621 attttcagta tcatggccgg tcatgatatt ttctatttct tagatattat cattttgatt 778681 gcggtattga tctggagacc tgaattaaaa gaatacaaaa tgaaaaaacg ctttgcatct 778741 ttagtgatcc tttctgggat cgcactgttt ttcatcaacc tgcactatgc ggaaaaagac 778801 cgtccgcaac tgctgacaag aacgtttgac cgcaattata ttgtgaaata tttaggttta 778861 tacaactaca ccatttatga cggtgtacag acggctcaaa cagagacgca aagagcctat 778921 gcaagcagcg atgatttaac aagtgtcgag aattacacga cgtctcatta tgcgaaacca 778981 aacgccgagt acttcggctc tgccaaaggc aaaaatatca ttaaaattca cctcgaaagc 779041 ttccagtcat tcctgattga ctacaagcta aacggtgaag aggtgacgcc tttcttaaat 779101 aaacttgcgc acggcgggga agatgtgacg tattttgata acttcttcca tcagacaggc 779161 cagggaaaaa catctgatgc cgagctgaca atggataact cgatcttcgg tcttcctgaa 779221 ggctccgcgt ttgtgacgaa aggcgaaaac acctaccagt cgcttcctgc gattttagac 779281 cagaaggaag gctatacaag cgccgtcctg catggtgatt acaaatcgtt ctggaaccgt 779341 gaccagattt acaaacatat cggatatgac aagttcttcg acgcaagcac gtatgatatg 779401 tcagatgaaa atgtgattaa tatggggctt aaggataagc cgttctttac agaatcgatt 779461 ccaaagcttg aatctcttaa acagccattt tatgcgcatt tgattacatt gacaaaccat 779521 tatccgttta accttgatga aaaagacgcg tctcttaaaa aagcgacaac aggcgataac 779581 acagttgaca gctacttcca gacagcgcgt taccttgacg aagcgcttga gcaattcttc 779641 aaggagctga aggaagccgg cctgtatgac aactcagtca tcatgattta cggtgaccat 779701 aacggtattt ctgaaaacca taaccgagcg atgaaagaga ttcttggaaa agagatcaca 779761 gattatcaaa acgcacagaa ccagcgtgtg ccgctgatga tccgcgttcc tggcaaaaaa 779821 ggcggagtga accatacgta tggcggcgaa attgacgtca tgccgacact tctgcactta 779881 gaaggaattg attctcagaa atatatcaac tttggtactg atttattctc taaagaccac 779941 gacgatacgg tggcattcag aaacggagac ttcgtaacgc cgaagtacac atcagtcgac 780001 aatatcattt acgatacgaa gacaggtgaa aaactgaaag cgaatgaaga aacgaagaat 780061 ctgaaaacaa gagtgaacca gcagctgagc ctttcagaca gtgtcctgta caaagacttg 780121 ctgaggttcc ataaactaaa tgatttcaaa gccgttgatc cgtcagacta tcattacggc 780181 aaggagaaag aaatcaaata agatgaaaaa gagccttgag cgggcgcatt gccttcgctc 780241 aaggctcttt ttttggttat acaaccaact tgaaaaaata gattccattt ggtcaccaag 780301 gctggctttc tctcatatca ttacagtaga ttttgaaacc ggattgaaat cggacaaatt 780361 atcggggaaa tgccttgata gattgtgaag atgtaccagg tttcgaactc aatattcata 780421 gagatgaggg gtagagatga aagcggtcat tctctgcggc ggaaaaggaa cgagaatgag 780481 tgaagtcacg aatgacattc ctaaaccgct cgccatgata ggcggcaaac cgattctatg 780541 gcatattatg aaaatttatc agtactacgg agtaaacgag tttattctgc ttttgggcta 780601 taaaggagaa aaaatcaagg aatactttct cgactatgaa tggaagcaca acagcctgac 780661 actcgacagc tctacgggag aggtacagat gctggggcag cctgaaacgt ggaaaattac 780721 gtttttggag actggggtag atacgctgac agccggaaga atcttgcagg cgaaagacta 780781 tatcggtgat gaaacatttc tgctcaccta tggagacggg ctggccaata tcaatctttt 780841 ccatctcatc agctatcatc agacaaaagg tgctgccgcg actgtcaccg gcattgacaa 780901 agtctcgcag tttggcacct tgacagttga ggatggcatg gcgaaaacat tttctgagaa 780961 gacatcaagt gatggaatca tcaacggcgg attcttcgtt cttagtccaa aggttttcga 781021 ttatttgccg aaggacggga acacgatgtt cgaagatgaa ccgctgaaga accttgccaa 781081 agatggggag cttgctgtgt accgccatta cggattttgg acggccatcg atacgtataa 781141 aaatctctta gaagtcaaca aaatgtggaa tcaaggacaa caagtatgga aggtatggtg 781201 aattgatttg agtttctgga aaaataaaaa cgtatttgtc acgggatgca caggtctttt 781261 aggaagctat ttggtgaaag agctgatcga acagggcgca aacgttacgg ggctagtcag 781321 ggatcatgtg cctcaatcca atctttatca gggagaacat atcaagaaaa tgaacatcgt 781381 gcggggctct cttgaggact tggctgtgat tgaacgcgcg cttggcgagt atgagatcga 781441 cacagtcttt catcttgctg cacaagcgat tgtcggcgtg gcaaaccgca acccgatttc 781501 tacctttgaa gcgaatatcc tcggcacctg gaatattctc gaagcctgcc gcaagcatcc 781561 gttaattaag cgggtcattg tcgcttcaag tgataaagct tacggcgatc aagaaaacct 781621 tccatacgat gaaaacatgc cgctgcaagg caagcacccg tacgacgtct caaaaagctg 781681 cgcagatctg atcagccaca cctattttca cacgtacggg cttccggtct gcattacgcg 781741 ctgcggaaac ttatacggcg gcggagattt gaacttcaac cgcatcattc ctcagacgat 781801 tcagcttgtg ctgaacgggg aagcgccgga aatccgaagc gacggcacat ttgtacggga 781861 ctacttctat attgaagacg ccgttcaggc ttatctgctt cttgcagaaa aaatggaaga 781921 aaacaatctt gccggagagg cctttaactt cagcaatgag atccagctga ccgtacttga 781981 actggtagag aaaatattaa agaaaatgaa cagtaatctg aaacctaagg tgctgaatca 782041 gggaagcaat gaaatcaaac atcaatattt atccgcggaa aaagcaagaa agctgctgaa 782101 ttggacaccg gcctacacta ttgatgaggg acttgaaaaa acgattgagt ggtatacgga 782161 attcttcaaa aagtaatgtg aaacgaggtg aacaagactg tgaccagcgc gtattgcacc 782221 gttttatcaa aaggaagatt atatcaggca gtcgctttgt ttaagtcgtt agagcaagtt 782281 gatcaagaca gtcccatttt tatactttgc atggatgaag atacgcaccg cgtgttacag 782341 aagctgaaga tgaagcagct gaaccttgtg ccggtggccg ctcttgaaaa tgaattgctg 782401 ctgaagctga aggaaactag agatcaaagt gagtattgct ggacgatgaa gccgatcttt 782461 ctgcaagctg tgctgaacag caatcctgag ctggagcgtg tgacgtatat tgacggggat 782521 ctctttttct atgcagatcc atcgccgatt tttgaaaacc agccggactg ctcggtgttg 782581 ctttcacgag gggatattgt aatcccttct tttgagaaag agcagattga catgctgcag 782641 cgtcttttag gcagatataa ttccgggttt atcagcttca agcatgatga tgcaggcacg 782701 gattgcttgg agtggtggaa ggaacgctgt cttgaggaat gcaaaaatgc accgggtgaa 782761 gggaaattcg gtgatcaggg ctatttggat tatatgtctg agctgtttcc gaatgtgtgt 782821 gacattacaa cacccggcgt gaacatcggc cattggaatt atggacagca tacgttttcc 782881 tggaaagatg gccggatcgt gctggaggat ggcagtccgc tgatctttta tcatttcagc 782941 ggataccgaa tcgtcagcat caatgaaatc aaacagattc atgaaacaac ccgcacagat 783001 ctgccgtttg tgcatgaact gtatcaagag acactgccgc atatcattca gcacatgcaa 783061 acgttagacc ctgaatttaa cggttttgct tcaaaagatg acaacaaata aatgagtaaa 783121 tacaggaagt gaaaatgaag tgaaagcaag cgttattatt cctgcatata attcgaagga 783181 gcgtctttac aacagccttc tgtcattaaa ccagcaggag tgcgatgaag aatttgaagt 783241 cattgtagcg gacaatggct ctgaggacgg gacgctctcg atgcttgagt catttcaagc 783301 tgattttccg ctgatcttta cacggattaa agaaaacagg ggcattgcgt acggacgaaa 783361 tcaggcgctt cgcaatgcca gaggagacat cctgattttc catgacagcg atatgcttgc 783421 ggcaaaggac cttgtggcaa aacatattaa agcccatgag aacgaagaga atctcgtcgt 783481 gtgcgggttg ttttggaaac ggatctacag tttttactat gaacgatttg aagaagaaca 783541 taaggaacag ctcgcaaagc tcacaggtga aatgccgaag aaagacaaac aaaagctgct 783601 ggaggaagcg gacatcaaaa acggaagctt tcttgataaa agctttgacc tcgataccga 783661 ctttatagac gtgctcaaga agattttaga tgagtacggc gatgacttga aaggctatca 783721 tatgccatgg cgctttttta tcacgaataa ttcctctgtg aaacgcaagc atgtggttga 783781 cctcggttta tttgacgaag gcattgtgcg gtacgggttt gaggattatg acctcgggat 783841 caggcttcat caggccggat tgaccttcag gcttcgccgt gatattgtca gtgttcatca 783901 ggaacatcca agcaattgta agtctgtaga cgatattcgg gcaaacattg cctatatgtg 783961 cgataaatac aataacatcc gctccttaga cgttcatctc gcttttaatg ggccgttccc 784021 gcctgacatg acgaacagaa tcatggctga tattcaaaag ctgctggaat cacagaaata 784081 tgatatgctg ctgaatctgt ttcttgagct tctgcatgtt gttaaagagc gcaacattga 784141 tccggattgg cgaaagaaat ccccaagggt gacggcgaaa agctttgatt tgcaaactgt 784201 ccgcaagctt ctgcctaagg cgaagaaaaa gctaggcgtg aacgattttg ccaacgcact 784261 gtatgcgctt gtcaacgatt tgctgcacgt ggatcttaga tcattggatg tggtataagt 784321 gagtacattt catttttcaa cgatagtgtc aaggacacat atctttaagc tcatgcctat 784381 gattcattct ctccatgagc attgcgatga ttttcattta tatgtgctgt gtgtcgacca 784441 gaaagcgtat gaattgcttc agcacgttcc atgggagcat gtaacctttg tgcagctgca 784501 tgaaatggaa gacccggagc tgttgaaagc gaaaagcaac agaacgtttc atgaatattg 784561 ctggacgtta aagcccgcct ttttgtttca tgtgatgagc aagtgggatg acgctgaata 784621 ctttgcccat atggatacgg atctattttt cttttctgat ccggcacgta tttttgcaga 784681 aaacccaacg gcgtctctgt atttgactga tcatcgtaat tcgccgcgct tcatgtccta 784741 ctacgaccga accggacgct ttaatacagg ctttgtcggc gccggtaata caaaggaagc 784801 atatgaagcg gtgtggcagt ggagacagga ctgtattgaa ttttgcacgg tcgaaatgga 784861 tacggaacga aagacatatg gtgatcaaag atatgtggag aaatggccgg agcagtttaa 784921 aggtgttcat gttgtcaaat ccataggagc caatacagcg ctttggaata tcgaaaacta 784981 taaggtcggg caaaaggacg gccgcgtgta tatagatgaa acgccgctga ttttctatca 785041 tttctctggg tttacgctgg tgacagaaaa agagtttaat ctttgctggt actaccggat 785101 tgaagacgaa gcgacaatta agatgattta tatgccctat atattaaatc tgaaaagatg 785161 gattgatgaa atacagtcgg cgtttccgga ctttgcggat ggctttatcc cgaagcacgc 785221 agtgcctgac actcatttta tccagctgga ttaaaaaacc ccctgccgcc tggcaggggt 785281 tttttcagct atgccattct ctcagcttct ggtcacttgg caataggaag gcaaggatgc 785341 cgaggacagg gagaaaggca atggcgatca tcgtcggggt cagtcccgcg gcatcaatca 785401 gagcgcccag cgccacagcg ccgattgcgc ccatcccgaa ggcaagcccg acggttaaac 785461 cggacattgt gccgattttt ccaggaacta gctcctgtgc gtagacgacc gttacagaaa 785521 agctcgacat cagaaccaag ccaatcaatg cgagcacgcc gtaggcgaga accgggccgg 785581 caaatggcag cacaatcgcc agcggcgccg agcataacag cgaaccgagg ataacgaagc 785641 gttttccaaa acggtctgca agcgggccgc cgagaaacgt gccgatcgcg ccgaacagca 785701 agaagacaaa aatatagctt tgtgcctgct gaatgcttac gtgataggta tccatcgcgt 785761 aaaacgtgta aaagttaccg atcgcactcg tataccaaga acgagcaaaa atgagaaata 785821 taataataat aagagcagat acaacagatt tggtgatggc cgtgttttca gccgttttct 785881 tttgcttgcc tgatttctgg gcaaggctgc cgagacgtga ggcgtaccat ttcgcaatat 785941 acatgagaaa cataacagca agcgcggcga caagcgtgaa ccaaacagcg ccgaattgcc 786001 cgagcggcac aaggatcagc gcggtgatca gcggtgccat cgcctggcct gagtttccgc 786061 ccacctgata aatcgattgg gcgagcccgc gttttgtgcc ggcggccata tacgccacac 786121 gggagccctc cggatggaaa atggccgagc ctaatccaat gaaaaacaca cagcataaga 786181 tcgttatgaa tgacggggca aatgcaaggc ccaaaatgcc aagcatgctg gcggtcaaac 786241 cgactggcag cgcatacggc cgcggccgtt tatcggtata ccagccgaca acaggctgca 786301 tgacggatga caccatgttt aatgtgaaag caatgatgcc gagctgtgta aacgtcaggc 786361 tcatggagcg ttccaaaata gggaacatgg ccggaatcac agcctgaagc gaatcgttga 786421 gcatatggca aattccgata ataatcaaaa tcggatacac cgtggtgcct ggtttttgaa 786481 ctgttttttc ttttaacggg gcggcgatag ccattgagtc tcctccttac atatataacc 786541 aaagcatacc accatattat tcataaggtg aagaatttat caagaggaaa aaagattctt 786601 atgaaagaaa taccgtcagc ctgattagca gctgacggta ttttcgatat tcaaaatgtg 786661 atatagctct tcaagcttac gaatctcata ggttggtatg atctctggca cattcggctt 786721 catgtcaggg ttcatccagc aagtatcaag cccggcgagc tgtccgcctt tgatatcagc 786781 agttagtgaa tccccgatga ttaatgtgtg ctctgctgaa aattgaggaa tccgttcaaa 786841 cacgtaattg aaatattcct tcatcggctt ttggaagccg gtgtcttcag aaacgaaaat 786901 gtccttgaag aatggaaata atcctgaatc acggagacgc ttatattgtg tgtgagacac 786961 gccgtttgtc acgatgtaca aatcaaactg ttgctgcaga tttgagatga gatcaaatgc 787021 accgtcaata agctgatgtc cttcttcaag aaagcggcgg tatttttgct caagcaaagc 787081 gccgtccgct tcgtaaccgt actccttgag caaagcggaa aaacgtgtgt ttacgacttc 787141 atcccgtgtc atcttacctt cttcaaaggc tctccagaga ccttgattga tggttttata 787201 ctgcgccttc atgtcatttg ttaaaggaat gttctgatct tcaaacagca aacgcagggc 787261 taaagcttct gccgcttgaa aatcaaggat ggtatcatct acatcaaata ataaagtgcg 787321 gtatcgcttc atctgtgtgt ctccctttct catatgtatt caaagtatag cacataaaaa 787381 aaggaaaaag ccggcgggtg aggcaccgcc ggctgaaaag agattatttg tttaataagc 787441 tgtgttttct cgaatatagg aagtaaacca gcgttccgac agcgatccag atgacaaatg 787501 aaagccatgt gacgccggga aggctgtaca tgaaccaaag gcagatgcct gcgctgataa 787561 tcggcacaac cggaacgaat ggcactctga aggacgcttt gatttcagga tgtttctttc 787621 ttaacacaat gacagcaatg gaaatgaccg taaacgcggc aagtgttccc atgttcacca 787681 gatgggccag cgttccgagg ttaataaagc cggcgattcc cgctgcaacg atccctgtca 787741 gccatgtgtt gcggaacggg gttttaaatg acggatgaac ctttgcgaac aatccaggca 787801 gaaggccgtc tctgctcatg gcaaatgtca agcggacctg tgcgtacagc aaagcgagca 787861 tcaccgtcgt aatcccgata atcgcaccga cagaaataat tccggcaaca gcgtcctgtc 787921 cgacgaattt cagcgcaaag gatacaggat ctccgacatt caatttggca taaggcatca 787981 tgcctgtcag cacaagcgat accgcgatgt acagaaccgt acagacggct agagctgaaa 788041 taatgccgac gggcatgttt ttttgcggat ttttcacttc ctctgatgcg ttagaaaccg 788101 cgtcaaaccc aaggtacgcg aagaatacag tggcagcgct aagtatgacg cctttcatcc 788161 cgaatggcat aaaaggagac cagttatccg gtttcacata gccgatgccg acaataatga 788221 acaataatat gatcgcgatt ttcatcagta cgatgacgtt gttaaagcgt gtgctttcct 788281 tgacgcctct gctgacaatc gcagtgatga ggagaatgat caccgcagcc ggaaggttaa 788341 atacggcgcc cgccatgctt cccggcgctc ctgtcagtgc agccggaata tgaagattga 788401 agccggcaag cagtgattga aagtatgaag accagccggt ggcaaccgcc gacagtgcaa 788461 tgacatattc aagcatgaga tcccatccga tcaaaaaggc gagcagctct ccaagtgtca 788521 cgtatgagta tgagtacacg cttcccgaaa tcggaatgga agacgaaaac tcagcataac 788581 agaaagcagc cagcgcacag gcgagccccg ctaaaataaa cgatatgatg agggcgggac 788641 ctgcaccggt cgctgccact gttcctgtaa tgacaaaaat ccctgtaccg atgacacaac 788701 cgataccgag caaggttaaa tcaaatgcgc ttaacgtacg ggcaaggctt tttgacttgc 788761 tctgcgcact caatgtttca agcggttttt ttctaaataa tgaactcatc aaaagttcct 788821 cctagaaata ttcaaaatat tctaatcatt atatgcagtt cttgttgtat tatattgtcg 788881 aaatttgacg tagtcaataa aatatttttc tgctttaaat gatagaagcg aaacagcgtt 788941 gtcgtatcat aggatagtaa tttttactaa tcgtatattc aattttatgc aagatgaacc 789001 gatagaaaaa atagattcgc ccatattttg atttgcggtt ataaaggaga tgctgaccat 789061 gtttcaatat gaagagttga ataaacagtt tatcggcggg aaatggcagg agggcagcag 789121 cccaaatgta ttggaaaaca aaaatcctta tactcaaaaa acattcacaa cattccgtaa 789181 agcgactgct gacgatgtag atgaagcgta tcgggcagcg gcgctggcaa agaaaaaatg 789241 ggatgcggtc aacccgttcg agaaaagaac cattttagaa aaagccgtca cgtatattga 789301 agaaaatgaa gaagccatta tttatttgat tatggaggag ctaggcggta caaggctcaa 789361 agcagctttt gaaatcggtc ttgtcaaaaa catcataaaa gaagcggcaa cgttcccaat 789421 ccgcatggag gggaaaattc ttccgtcaac aatagatggc aaggaaaaca gattatatcg 789481 cgtgccggca ggcgttgtcg gtgtcatcag tccgtttaac ttcccattct ttttatctat 789541 gaaatcagtg gcgcctgcac tcggagccgg caatggcgtt gtgctaaagc cgcatgagga 789601 aacgccgatt tgcggcggaa cgctgattgc gaaaattttt gagaacgcgg gaattccagc 789661 ggggctgctg aatgttgttg tcacagacat tgctgaaatc ggcgacagct tcgttgagca 789721 tccagtgccg cggatcatct catttaccgg ttctacgaaa gtcggcagct acatcggaca 789781 gcttgcgatg aagcatttta aaaagccgct tcttgagctt ggcgggaaca gcgccttcat 789841 cgtacttgag gatgcagata tagaatatgc ggtcaatgcg gcggtgttca gccgatttac 789901 acatcaaggg cagatttgca tgtcagccaa ccgcgtgctt gttcattctt ctatttatga 789961 caagttcctt gagctgtacc aggcaaaagt ggaatcgctg aaagtcggcg acccaatgga 790021 ccctgatacg attatcgggc cattaatcaa cagcagacag acggacgggc tgatgaagac 790081 tgtagagcaa gcaattgaag aaggcgctgt accagtgaag cttggcggat ttaacgggac 790141 gatcgtggaa ccgacgatct taaaagacgt caaaccgttc atgagcattg ccaaggaaga 790201 gctgttcgga ccagtcgtct cctttatgaa gtttgattca gaagacgaag cggtggatat 790261 cgcaaacgaa accccgtttg gcttgagcgg tgccgtacat acgtcaaatc ttgagcgcgg 790321 cgtggctttt gcgaaacgca ttgaaacagg catgattcac gtcaatgaca cgaccatcaa 790381 tgatgaaccg aatgtagcct tcggcggtga aaagcaatca ggcctcggcc gtttaaacgg 790441 tgagtggagc ctcgaagaat ttacaacgct gaaatggatc tcggtccagc acgaaaaacg 790501 cagcttccct tattaatgaa aaggagtgaa tggaattgac cataaatacg gaaaaagaaa 790561 ccgcagatat tctggacgca tttatcaaag tagcccctta tttaaacagc ctggttcagg 790621 atgatattac aatcggcatt tatgatacgg aaaaactgct cgtgaatata ccggccaaaa 790681 ccttttcgct gaacgtaaaa gccggcgatc cgctgcagga aggggatatc atcacagatg 790741 ccatccgcag caatcagaag aagacgagca tggttccgaa agaattgttc ggcttcccat 790801 tgatcgcgcg tgccatcccg ctgcacgacg agaatggaag agtcattgga ggcgtcggcc 790861 tcggaacgag ccttgaggag tcgtcaaagc tgcatgatgt cgcggaaagc ttatcagctg 790921 ttgttgaaca aacagccgcg gctatttccg acatttctga atcaattaac gggttttcaa 790981 ctcaaatgtc gggcatttcc tctcaggcga aaaaagtaag cgaaagcgcc ggtgaaatcg 791041 ccgatatttc agtaactgtt aaaggcatct cggaccaaag caatctgctc ggcttgaacg 791101 ccgcgatcga agcggcaaga gcaggggagt ccggaaaagg attctctgtc gtcgcagatg 791161 agatcagaaa gctagcgacg cattcaaaag aaaatgtcgg ccaaattgac cagattacga 791221 aaaaaatcca cagcctgctg aaagggctgg aggaatccat tgagtcgatt aaccagcata 791281 cagacggaca agccgctgct gttgaacaaa tttccgccac gatgcaggag atttcaggaa 791341 gcgcgcagca tcttgcgaaa atggccgaaa aagcgcttga ggaagagtaa gagaccgggg 791401 acaaacatcc ccggtctttt tcttatcctg catttccatg aaattcgtct gacgttttac 791461 tagttttatt ccagcggctg atttaaaatg tacacatgaa cttacgtgag gattgatagg 791521 aaccatgagc atattaaaag cggaaaatct ttataaaaca tacggagata aaacattatt 791581 tgaccatatc tcctttcata ttgaagagaa tgagagaatc ggattaatcg ggccgaacgg 791641 aacaggaaaa tcaacgctgt tgaaagtgat tgccggcttg gaatctatcg aagaaggaga 791701 aatcacgaaa tccggaagcg tgcaggtcga atttcttcat caagacccgg agctgcctgc 791761 ggggcaaaca gtgctggagc atatctattc cggtgaatcg gctgtgatga aaaccttgcg 791821 tgaatatgaa aaagcgctgt atgaactggg gaaagatccc gaaaatgaac agcgccagaa 791881 acacctgctg gcagcacaag cgaaaatgga cgcgaacaat gcatgggatg caaacacctt 791941 ggcaaaaacc gtattgtcta agctgggcgt caacgacgta acaaaaccgg tcaatgagct 792001 ctcaggcggc cagaaaaaac gggtggccat tgccaaaaac ttaattcagc ccgctgattt 792061 gctcattttg gacgagccga caaaccattt ggataatgaa acgattgagt ggcttgaagg 792121 gtatttaagc caatatcccg gcgccgtcat gctggtgacg cacgatagat atttcttaaa 792181 ccgtgtcacc aaccgcattt atgagcttga aagaggcagc ctctacactt acaaaggcaa 792241 ctatgaagtg tttttagaaa aacgcgcgga acgggaagcg caggctgagc aaaaggaaac 792301 gaagcggcaa aacctgctgc gccgcgaact ggcttggctc agacgaggag cgaaagcccg 792361 ctccacaaaa caaaaagcga gaattgaccg ggtagagacg cttaaagagc agacaggccc 792421 tcagtcatca ggttcactcg attttgccat tggctcgcac cgtctcggaa aacaggttat 792481 tgaagcggag aacgtcatga tcgcttatga cggccgcatg ctcgtcgacc gttttaatga 792541 acttgtcata ccaggtgaac ggatcgggat catcgggccg aacggcatcg ggaaaacaac 792601 gctgttaaat gcccttgccg gccgtcatac gccggacgga ggcgatatta cgatcggaca 792661 gacggtcaga atcggctact atactcagga tcatagtgaa atgaacggtg agttaaaagt 792721 cattgactat ataaaagaaa cggcggaggt cgtaaaaacg gcagatggcg atatgattac 792781 agctgaacaa atgctcgagc gtttcctctt cccgcgttcg atgcagcaga cgtatatccg 792841 caagctgtcc ggcggggaaa aacgccgttt atacttgctt caggttctca tgcaggagcc 792901 gaatgtcctg tttctcgatg agccgacgaa cgatttggat actgaaacat taagcgttct 792961 tgaggattat attgaccagt tcccaggcgt cgtcatcacc gtatcccatg accgctattt 793021 ccttgaccgc gtcgtcgacc gtttgattgt atttgaagga aatggtgtca tttcccgctt 793081 tcaaggctcc tatagcgact atatggagga gtcaaaagcg aaaaaagcgg ccccaaaacc 793141 ggcagctgag gaaaaaacgg ctgaagccga gccgaagaaa aaacggaaaa agctttctta 793201 caaagaccag ttggaatggg acggcatcga agataaaatt gcccagctgg aagaaaagca 793261 tgaacagctt gaagctgaca tcgccgcagc aggcagtgat tttggcaaaa tccaagagct 793321 gatggccgag caggcgaaaa cggcggaaga gcttgaggct gcgatggacc gctggacaga 793381 attgtccctc atgatcgaag aactggaaag ctaaaaagcg tggccgcagc aggccgcgct 793441 ttttttcaca taatggacaa aaacgaaccg gcctgcttat gttaggataa agttgtgtgt 793501 cagcggcaca tggaaaacta acggagatga tgaagtatga catgggcgat cgtgatgtta 793561 attctcatga gtctggtgaa aatcgtatta acctgtcttc ctacaggcgt catagaatgg 793621 ctgctcggca aatttgaagt gcacgccaag ctgagtgacg aaaatgcgag tctctctcta 793681 gatggaaaac gcctcgaggg tgcagagaag cagaaagtga ttgatcaatt taacgaagct 793741 atcttcctgg aaaaatatta tatctatcca ggtgatgaag agcgttattt acatccggaa 793801 aacggcggca cgcctctggt gatagataca aaaaaaggaa aaaaagacgt gaagctgttc 793861 gtgtaccgct acgacgacca tatcgacgtc gtgaaacagt acaagaagaa agtgatcgcg 793921 tatcgagtgc tttctgaaag ccttcaaaaa gagtctctgt cagtggcggg aagtttagct 793981 taaacaggaa agtgaaagac gggtgctgta tgctgctcgt cttttttatt gttttttaaa 794041 acttaacgtt tacgttaagg ttcaaaaggt gtataatggt aacagaaacg gcgaaggggg 794101 atttaccttg gaatggatga agattgatca agtggccaaa agaagcgggc tgacaaagcg 794161 gaccatccgg ttttatgaag aaatcggctt gattccggcg ccgaaacgga cagacggcgg 794221 tgtaaggctt tattcagagg atgatatgga ggagcttgag aaagtcatca gcacaaaaga 794281 ggtgctcggt ttttcccttc aggagcttca gcatttcatg gaaaccagcc gccagctaga 794341 gttaaacaaa gaggggtatt tgttgtcact ggatcctaag gaacggaaag aaaaactgga 794401 ggaaattcag gaaaccctga atcaccagct ggatttgatt gatgagaaaa tccgcacatt 794461 ccaaagcttt aaagaacgcc tgcagggcat gaaaggcaaa gcggaacgcg ccattcaatc 794521 aatcgaatga aaagtttgtt aaacgctatt tttgtagcgt ttcttttaat ggaataaaga 794581 tggaggttag gtcaaatgga taagacaaca caagtgaatc agaaaacggg tttgctcagc 794641 cagccaaaag cggtatgggc tgtcgcgttt gcctgtgtga tttcttttat gggaatcggg 794701 ctggtcgatc caattcttcc ggccattgcc gcacaattgc atgcttcacc tagtgaagta 794761 tcactcttgt ttacaagtta tttgcttgta accggattta tgatgttttt ctcaggagcc 794821 atttccagcc gcatcggcgc gaaatggaca ttaattctcg gacttatttt tattattgtg 794881 tttgcggggc ttggcggcag ctcaagctca atcgctcagt tagtcggcta tcgcggcggc 794941 tggggattag ggaatgcttt gtttatttca acagcgcttg cggtcatcgt tggcgtgtca 795001 gtcggcggca gcgcccaagc gattattttg tatgaggccg cgctcggtct cgggatttct 795061 gtcgggccgc ttgcaggcgg agagctcgga agcatttcat ggcgcgcacc gttttttgga 795121 gtatctgtcc tgatgtttat tgcgttaatc gcgatttctt tcatgcttcc gaagctgccg 795181 aaaccggcga aacgcgtcgg tgtgtttgat gcgatgaagg cactcaaata taaaggcctg 795241 ctgacaatgg cggtatcggc attcctatac aactttggat tttttatttt gctagcttat 795301 tctccgttcg tactggattt agatgaacac ggtcttggat atgtcttctt cggctggggc 795361 cttctgctgg cgattacgtc agtctttacg gcgccgctcg tgcacaaagc gctgggcaca 795421 gtgcgttcgc tagtcgttct ctttatcgcc tttgcggcca ttctcgttat tatggggatc 795481 tggacagacc atcagacttt gattattaca tgtatcgttg tcgctggtgc tgtcctcggt 795541 atggtgaata cgatcatgac aaccgctgtg atgggttctg cgccggttga acgttcaatc 795601 gcgtcttcag cctacagctc agtccgcttc atcggcggcg cgctcgcccc gtggattgca 795661 ggaatgctgt cagaacactt tactgcaagc acaccatata cagtaggcgg aatcgtcgtt 795721 tttgtcggca tgcttgtcct tctcatggga cgtaaacatc ttgctggaat taaggcgggg 795781 cattaataac gaaagacact gcgcatatgc agtgtctttt tattcgttat aatgcatcat 795841 aatcgaattg gtgcaggaaa ggacaacctt tatgacacaa ttttactatt ttccggctga 795901 aaactccctt tagaaaccgg ttttttcggt cagcaagaac ggcgttcgcg gaaagggcat 795961 ccgcttcggt caggcattga tgcggctggg atttatcttg cagaagctga gaatgtgtcc 796021 gttcatttac gattgccatt tcagtgatgg ttcatgctgt agaggggacg tttgccatgg 796081 ataaggcaaa acctgacgaa tatgatcaga aatgtttaga aacgctctat caatacatac 796141 acagcgtcat gaaaaacagc ttttctcggt cgagtggttt accgcttggg aagatgagga 796201 ggattttgag ctgtctgcca aaagagagct gacacttgat gaattcacat ctccattgca 796261 gctcatttta aaagacagag agcttttgag aatcgttcag aaaaaatggc agtaaaaaac 796321 ccgcccttta gcaggcgggt ttttttataa attaaagcac tttcgtcgtc caagactcgc 796381 agttccacgt ttctgtcgca atatccatat aaaagtctgg ctcgtgggaa atgagcagaa 796441 tggagccttt atattctttc agggcgcgct tgagctcttc cttggcatcg gcatccaagt 796501 ggtttgtcgg ctcatcgagc accagcaggt ttgtttctga gttgattagc ttgcacaatc 796561 tgactttcgc tttttcgcct ccgcttaata cggagacgcg gctttcgata tgctttgtcg 796621 tcagcccgca ttttgccaga gcggcacgga tttcatactg cgtataagaa gggaattcgc 796681 tccatacttc ttcgatgcac gtattgttgt ttgtttcctt gacctcttgc tcgaaatagc 796741 cggtatagat gtgctcaccg cgttcaacag agccttcgag cggctggatt tcaccaagca 796801 aacttttcag caatgtcgtt tttccgatcc cattcgcgcc gtaaagggcg attttttggc 796861 cgcgctccat gcggaggttg agcggacggg acagcgggga atcgtaaccg atcacgagat 796921 ccttcgtttc aaaaatcagc ttgcctgacg ttctcgccgg cttaaagtgg aattccggct 796981 ttggcttttc tgccgcaagc tcgatcatat ccatcttatc gagtttcttt tggcgggaca 797041 tcgccatgtt tctcgtgctg acacgcgctt tgttgcgggc gacgaaatcc ttcagctccg 797101 cgacttcctg ctgctgcttt ttgtaggccg cttcaagctg ctgttttttc acctcgtaga 797161 cttccataaa ctgatggtag tcgccgacat aacgtgtcag ctcttgattt tcaacgtgat 797221 aaatcaggtt gatgacacta ttcaagaacg gaatatcgtg ggaaatcagg atgaacgcgt 797281 tctcgtattc ctgcaggtag cgtttcagcc attcaatatg ctgttcatca agatagttgg 797341 tcggctcatc gagaagcaga atttccggct tttcaaggag aagcttagcg agaaggacct 797401 ttgtgcgctg tccgccgctc aaatcggtga catctcgctc taaaccgata tcgctcaaac 797461 cgagaccgcg ggcgatttct tccaccttgg aatcaatgac ataaaaatca ttgtttgtca 797521 gcgcgtcttg aatgacgccg acttcttcaa gcagcttctc gagctcgtcg ggatcagcct 797581 cgcccatttt gttgtaaatc tcgttcattt cctcttccat cgcaaataaa taatggaatg 797641 cgtctttcag gacgtcgcga atggattttc ctttttccag cacggtatgc tgatcaaggt 797701 atccgacacg gacatttttt gaccattcga cttttccctc atcaggttca agctttccgg 797761 taataatatt catgaaggtt gattttcctt caccgtttgc gccgatcaag ccgacgtgct 797821 cgccttttaa caggcggaag gaaacgttat taaaaatggc ccggtccccg aaaccgtggc 797881 ttaaatcctt tacagataaa atactcatgt ttacacctct atcgttatca aacacgcaca 797941 atcggcgtgt aatattcacc cttttgatta taaaggagga ttcggaatgt tgaaaggtat 798001 aggaaagaaa aagaaaaatt gcgttccggg cgaggttttg agatactatg gaatagattt 798061 caggaattga ggagaacaaa atgacgcaaa cttggccatt tttacataat gcacaatcat 798121 ttatacaaga gaattggaat gcttccggct ttcaaaagcc aacccctgtt caggagcagg 798181 cagcccagct gatcatggac ggaaaggatg tcattgcaga atcgccgaca ggcacaggga 798241 agacgctggc gtatgcgctg ccggtcttgg agcggatcaa accagagcaa aagcatccgc 798301 aggcggtgat tttagcgcct tcccgtgagc tggtcatgca gatttttcag gtgattcagg 798361 attggaaagc gggctcagag ctgcgcgcgg cttccttaat cggcggggcg aatgtgaaga 798421 aacaggtcga aaagctgaag aaacatccgc atatcatcgt cggcacgcca ggcagggtgt 798481 ttgaactgat taaagcgaag aaactcaaaa tgcatgaagt gaaaacgatc gtgcttgatg 798541 aaacggatca gctcgtcctg ccggagcatc gcgaaacgat gaagcaaatc attaaaacaa 798601 cattaagaga ccgccagctt ctatgttttt ctgccacgct caaaaaggaa acagaggacg 798661 tgctccgcga attggcgcaa gagcctgagg tgttgaaggt gcagcgaagc aaggcggagg 798721 cagggaaagt gaagcatcaa tacctgattt gcgaccagcg cgacaaagtg aagctgctgc 798781 aaaagctgtc aaggcttgaa ggcatgcagg cactcgtatt tgtgagagac attggcaacc 798841 tgagtgtata tgcggaaaaa ctggcatatc accacgttga actcggcgtt ttgcacagtg 798901 aagcgaaaaa aatggagcga gcgaaaatca ttgccacatt cgaagacgga gagtttcctc 798961 ttttattggc gactgacatt gccgcacgcg gtttagatat tgaaaacctg ccatacgtga 799021 ttcatgctga tattccagat gaagatggct atgtccacag atcaggacga acaggccggg 799081 ccggaaaaga aggcaacgtg ctgagccttg tgacaaaatt ggaggaatct aagctgaaaa 799141 aaatggcgaa gaagcttggt gttgagctga gtgaagctgt gtatgcaggc ggaaaactga 799201 agacgaaata aaaagaaggg cgaagagccc tttttttgtt gtaaaataat agaaaagatt 799261 ttgcgcggag gtgggaaaat ggcttcaata gacaggtttc aagtaatgca ggagccagag 799321 ctgaaaatcc ttgaacactg gtttgagaat gaggatacca gacggagaat ggatgggatg 799381 ctgctattag atgagtggta tgcacgagta aataaagata aacacgatac tgtcatcatg 799441 gcgtatgatg gacagctgcc ggcagggatg gtcgttattg agttcggaga ggagcggaca 799501 tatattggat tgatcgtcaa tcctttgtac cggcttaaag ggtatggaaa acagatactg 799561 caaaagctga tgaccgaacc tgattttact agcgtgcgag aatgggtggc atgcattgaa 799621 gaagacaatc gaatcagttt agcttgcttt caagcagcag gattcacttt agaagacacg 799681 gaacctgatg aagatggttt tcttacgctg attcttcgca actgatctca tcgaaacaca 799741 aaaggagggc aaaaagccct cccgttttca tcttcattca gctcggatca ctgaccttga 799801 tcagctgttt ccctttattt tctcccttaa ataaaccgag aaacgcgtca ggaatgtttt 799861 cgaagccttc tgtgatggtt tcctcgtaat ggagtttacc agccttcagc cattctgcca 799921 gctgttttgc tccctcagaa aaacgatcgg agtagtcgct tacgataaag ccttgcatca 799981 gcgacttcgt tttaatgagt tttgattgga cacgagggcc catgtcatct gcttcgcttt 800041 ctgcgttata ggaagaaatg gcgccgcaca ccggaatgcg ggcaaattca ttgagcagat 800101 tcatcaccgc gtctgaaatc ggtccgccga cattgtcaaa atacacatcg acaccgtcag 800161 gacaagcgtt ttgaagcgct ttttggatat catccgctgt tttgtaattg atggcttcgt 800221 caaactgaag ctcctgtttt aaatagtcga ttttttcatc agagcccgcg atgccgacga 800281 ctcgcgcgcc tttgattttg gcaatttgcc cgactgttga accgacggct ccggcagctc 800341 ctgagacaac cacggtttcg ccttccttcg ggcgtccgat gtccagcaat ccgaagtatg 800401 ctgttaagcc ggtcattccc aaaatgccga gataggccga agcgggagca aggcttgtat 800461 caatttttcg caaggcagac tcgctcacag cggaaaattc ctgccagctg agatttccga 800521 tgacgatatc gccttttttc agatgattcc cgtctgacac aacttcagcg ataacccctc 800581 cagaaagcgc tttatccaag gcgaacggct caacatatga cttcgtatcc tgcatacggc 800641 cgcgcatata agggtcaacc gatacataaa gcgttttgac aagcacttcc ccttgcttgg 800701 gttcaggaac cggaatggtt tcaaagcgaa agtcttcatg aacaggaata ccttgtggac 800761 gtcttgctaa ttgaatttgc tgctgagatg ctgtcatttt catcctccta tcacttggtt 800821 gacaccactg taacatggac aggagaggaa atacaaaagg taagctggca tacaaaaaag 800881 gttatagatg agcttatgct ttctacaagc tcttttgttt taaaagttct ctttagtcat 800941 ttatcattat tagaaaacag aacagaaaaa gagctcctgt acacctagct aagattggct 801001 agtgtgtatg tcgattcttt ttcatattct tgcaagcatc tgcgaggggg agcttagtcg 801061 ttcacatttt gctttcgcat caatctgcaa tagcaaagtc tatgcgattt ttttacatca 801121 gcaaagattt gttcaatttt ttccttttat gccgagtttt tctgaaacag ataattgatg 801181 gtactcaacc attttctttt ggtcaataaa gtaatgttta cttattaatt aaacacgcga 801241 aaaagcaaac gaaaacataa ttaaatttta tatatttatt aaaagcttat atgtttattt 801301 accttttttt tgaattgtaa ttgagaaaat ccatatattg cggacactaa taaaagaata 801361 cctgctgaaa cataaactaa acgaactcca aggaaatctg aaatagcccc tatagccaga 801421 attgaaaaca taaaaatgaa ctgtactaaa gaagaccttg cagacattat attaattcga 801481 gtttgctcgg ttgttatgtt ctgaataagt gtttcttgtg taagatctct taatatataa 801541 gccggcccca taaagagaac caaaattaga gctaagtatg aattacttat aaaaccatat 801601 attaaagtta aacttccata tgagacagcg ccaattaaca taaaattaat taacttattt 801661 tgaaatctct ccgacagctt atatattata aatcccccta tcatcgaacc taaataatat 801721 gctccattaa taaatcccca ccatgattct cctttatgca agacttcgtt aacgaaagct 801781 aaagagacag atcctatcca aatcattcct gcccatgact caattaaatc cataataata 801841 attgttctaa gtttcttttg gctaaataaa taccgccaac cacttactat actcttattg 801901 ggagaatttt tttcacgtat gacagaatta gcgtggccat gtggtagaca aaataaaaga 801961 gaaagaagag atgtaaacaa caaaaagata gtaagtataa tggtatatcc ctcacctaaa 802021 aatgcaatta tgagaccacc taaagaccag cctacaaatt gaaaagtttg gtccactgta 802081 gataataatc catttgcttt tactcttcta tcaggagaga ttatttcccc tataattgca 802141 ctttttaaag gtgagaacca tccattaaaa aaggaaatac agctaataat aataaagact 802201 aaaatgagag tttgattaga gtaagttctt aataaagcat agaacaaaca tattaataac 802261 agcatttgta tcaattgaga aataattatt gtaagaggca gttttaatcg aattgttatt 802321 aacggtaata tagcacttcc aaaaatacga aaaataatac ttattaatgt caccatagag 802381 gcgatggttg tcgaattggt cattttaaac aaaaacgaaa tcactaccat agtatataga 802441 gaaaaaccta aatttgtagt ggtctggcta aataaaatag aataataacc tttactcata 802501 tgtatcctcc cttggaataa tttttctcgg taaagagctt aaacatattt aaacacctta 802561 aaacaacaaa agtaaagaaa aaatttcctt gtaaactatt tacttttatt ctatttattg 802621 ttattgttta tttaagttct ctgactattc tatcaatatt cagggaacca catatcttat 802681 taaagggggg aaaaccatga gaaaattaag aaaaaactgg agaaaatcga ttgttagccc 802741 ggttctttat actaatgaaa aatggtaaac acttagggaa tagcatttaa tgctattcct 802801 tatttcaaca aacaaatcgg gaggttatcg taatttgact ctattaatgc aagatcataa 802861 atcaatttac aataaagata tagaaatatt aattgaagtt gaagaactta ttacttctgt 802921 tccagaaaat aaaaaaaatg attttaagag tttaatcgat aatagaatta tgactctact 802981 aaataaaatt caacaccctg tagcagcgga aaatgtgttt gggatgtgta ttgcttatcc 803041 gaatacttac ataaggtata gattaattga tttcgttgaa aaatgggtac cttatttctc 803101 tgctgtagaa actataatca atctaaccca ggatccggat gatttagttt cttttaaagc 803161 tatggatgtc tgtgcaaatc ataaaattga agaatctgta gcatatttgt cttcgattat 803221 tgatgatgtc cgggagagta taagctaccc taaaaaacct gtgggattag gggcccaaaa 803281 agtattaagt acattattag atatattcgg tgttgaaaaa catgaagagc tagtaatgct 803341 aaaaaattat tttgatcaaa atggtatact tcctaataac tttgactttg aagaaaaaat 803401 tcctcaaagt ctaatagagg aattcgaaaa aacagaagaa gatgggatga ttttaattcc 803461 gggtggcttt tttgaattcg gtttaaatga aaatgaaatt cctgacaaaa catttaattg 803521 gaaagatgct gttcctagac aaaaagtatg gttacctcca ttttttatcg ataagtatcc 803581 tgttacaaat aaagattatg atatctttac cgagttcata gaggaaaatg ggcatatatt 803641 ctgtcatcct aatgaaccgc agaataaaca acatagaaga aatacatatt gggatgatag 803701 gtatttagat aatcatcccg ttacaggtat agatttttat gatgcatttg cttacgcaag 803761 atataagggg aaagaattgc caaccgagtt tcaatgggaa aaagctgctc gaggcgaaaa 803821 gggtaatgtc tggccttggg gagataaatt tgatcctgca aaggttcaat atgctggaag 803881 tctttataat gaacccatta cttctttaaa gtcctggaga gaaaatttat taaaagctca 803941 tgctgataaa gaattaaatc atttaacaag tgatattttt gaacaaaatg gtgaaagtcc 804001 ctatggagta tgcggtatga tcggcggaac atgggagtgg actagaagtg agcttaaaac 804061 aaagagagct ttccacccta tttttgagaa tgtaccattt aatagtgtta actcatttgc 804121 cgttcttaaa ggaggatcat tcttctctca tccaggctta atgttccctt cttttagagc 804181 aaaagatatt cctttctgtc gacacaatga aatggggatt agatgcgtaa agaatattcc 804241 agtatataaa attagagaat caattaatgg gccaattact aataaagcaa tttattaatc 804301 attctaggtt agagacttga taaaagtata ctaacattgt gtagtaatgt tcagcttgta 804361 gaaaaaacaa tgttttttct acaagatttt attttaaatg cttttcaaaa ttatcaggga 804421 ttgagaatca gaaaaagagc cattaagctc gatcttagct aggtattacg atcttctgta 804481 tattattgtg agaaatatag aagattcagt tagttagcat ttcgatttta agctgagcct 804541 gcaatagcaa agcatctgtt ttgattattc tttttctgat acataagcta attttgtcgc 804601 ttttcttttt tgtcttttca cgcatttcga ggatgactta ctataattct ttcagctttt 804661 ctatgtgtta agattcgaat agatgaaata actttaacaa gttggtcaat aagaacagat 804721 ttaactttat gttaaaagag tatctcgtat agaacataag aagaatgacg agttttttaa 804781 gattatcatc aattatgtga gaataaaata ttataaggga aaatgaaggc tgtcacgttt 804841 ctcgacagcc ctagggaatt cctctccttt tcatttcgcc cgtaatttcg ggcacagtcc 804901 cgtcggcagg cacattggct tctggtcgat cgggcttctc atgatgcagc attccaagcc 804961 gaagacttca cggaaaaatg gctgggtgaa cacatcttcc ggtgttccgg cgttgtatat 805021 ttttccgtcc agcacactga tcagatagtc agcatattga gcggcttggt ttaaatcatg 805081 gagcaccatg acaacggtgc ggccatggtc gcggttcagc tttttcagca gttcaagcac 805141 ttcaatctga tgtgagatgt ctaaatacgt ggtcggctca tcaagcaaaa gcaaatcagt 805201 gccttgcgca agtgccatgg aaatccaggc tctttgtctt tggccgcctg agagggcatc 805261 aagtgtccga tccttcagtt caatcatgcc cgttgcttcc agcgcccact ctaccatgtc 805321 atgatcctct tgggtatgct tggataacag ctttttgtga ggatgtctgc caaaatagca 805381 taattcctct accgtcaatc cttcaggagc ctgaggagat tgtggaagaa tggccagttt 805441 ttttgcgact tcttttgatg gctggcggtg gatgtctttt ccttctagta gcactgtacc 805501 gctttttggg gccatcagcc tggcgagcga tttgaggatt gttgatttac cgcagccatt 805561 agcgccgatg agcgcagtga tttttccttc ttctatcttt aagtcgactc cgtcaataat 805621 cactgtactg tcatatgaaa gagtgagctg gtctgcagcc agttttccca tggtatcctc 805681 tccctactgt ttcctcgctt cgaatttcaa taaatataag aaataaggcg cgccgatcac 805741 ggctgtcagt attccggcag gtatttcaac cggaggcatg atgccgcgcc ctaacgtatc 805801 tgcaattaat aatataatag caccaatcaa tgccgatgca ggcagtaaat atttagcttt 805861 ttctccggta agccgtctgg cgatatgcgg agcaagcaag ccgataaaac cgattgagcc 805921 gacgacggct acacagcttc ccgccagcgc caccgcggtg aaaatcagga tgaatctcag 805981 ccggtttgcg ttttctccga gaccctgtgc aagctcatcc ccgagtgaca taagatccag 806041 cttcggtatg agtatgcaga cgatcggaaa aagaatcaaa agccatggcg caagcagctt 806101 gacttcttcc cagtttcttc cccagaggct tcctgtcagc caaatgagtg cagcattcac 806161 gtcgcctgga aacttgacca tcatatattg cattccggcg tggcagaccg cgcctaaagc 806221 aatgcctgat aaagccagtg aagagggctg aatgctcttt tttcgggcta tcattaataa 806281 tagtacagca ataatggcgg ctccggcaaa tgcggagaac ggaagcacgt ataccggcga 806341 ctcaggaaag atgagaatca cagccatcgc cgcaagtccg gagccttttg aaatgccgac 806401 aacgtccggg gaagcgagcg gatttcggat cacaccctgt aaaatcgctc cggcagcggc 806461 aagtccagca cctgccaaaa tcgctaatat aatgcgggga aggcgatatt gctggatgat 806521 aaattcaaag gaatgatcca gtcccagcag attcgtcact accgcatcag gtgaaatgta 806581 taatgcaccg attccaatgc tgatgacgga cagaacgatt aaaatcacgg ccaatatgag 806641 tatcgccagt aaggggcgtt tttgttttct ggttgttttc ttcatttcag gtttcgccct 806701 ttccttgcca aatataagaa aaacggcgtt ccgataatcg cggtgacaat gccgaccggt 806761 gattcataag gaaatgcaat ccatctggcc agaacatctg cgtacaccag caaaatggca 806821 ccgaacagtg ccgaaaacgg aagcacgtat tgataatgtt ctccgatcag cttgcggaca 806881 atatgcggga cgagcagccc gacaaagcca atcggcccgg cgacggctac ggaagcgccg 806941 gaaagaatta aaataatcaa actgatcaga atcctgatgc cgttcatatt ttgtccaagc 807001 ccttttgctg tttcgtctcc gagaccgaga acagaaacag aaccggaaaa tacgagggca 807061 agcccgatgc caatgacaga aaaaggagcg atggttatga cgtcctgcca gttgctgccg 807121 tcgattgcgc ctgtcatcca gtacagaaca tcctcacctg actcatttaa aataatgatg 807181 gcctgtgtca tagaggagag gaacaagtgc acggccattc ctgacagcgc cagcttgaca 807241 ggcgtcattc cgccggatga ggcaatcata tacacaatcg cgccgcctgc tgccgcaccc 807301 gcaaaagcga atataacaga tgaatagggc gatgccggca gaatgacgag agaagcaaca 807361 acaaaaagcg atgcacccgc attcacaccg aaaatttggg gtgaagccag aggatttctg 807421 gtcatagcct gcatcagcgc ccctgctaca gctaggctgg cgccgacaaa aacgccgatt 807481 aatgtgcggg gaaggcgaag agtagagatg atgagctgtt cctttgaacc gtcccataca 807541 aaaagatatt tcaatgaatc tatgatgctg atgtctgagg ctcctactga aagattcagc 807601 ccaagcccaa atataaaaat aatcagtgca atgataaaca tcatcagtct tgatgatgag 807661 cgccgtttgg ctgaatgata caacagtctc acttccttac tgcgtctggt tgcaaaaacg 807721 aagaagcaag gattcccctc gcttctcatt tgtcctattt attatacact tttttaagca 807781 catctttggc gcttgtttca ctagacttga tgcctctgaa tcttgtccaa gtgtcacggt 807841 ccgcatcata gacttgtcca tttttcaccg ctttgagatt tttccagagc gggttcgttt 807901 tccactcatc tacaatggtt ttgccttcgt tggctgagat gaacaaaata tcaggatcga 807961 ttttgctcaa ttgctcaagg ctgacctctt gataggcgtt atctgacttc acagcgtgtg 808021 taaagcctag cattttaaag atttctccgt cataggatga tgatgtatga agctggaagg 808081 aatccgctct tgcaacgccg agaacgatgt tgcggttttc atctttcgga agttcggctt 808141 ttagatcgtt gatgactttt ttgtgctcgg caagcttttc ttttccttca tcttctttat 808201 ttaatgcttt agcaatggtc gtaaagctgt cgatcgtttc gtcatatgtc gcttcacggc 808261 tttttaattc aatcgtcggg gcgatttttt tcagctgttt ataaatgttt ttatggcgct 808321 cagcgtcagc gatgattaaa tcaggcttca aggaactgat gacctcaaga ttgggttcgc 808381 tgcgtgtgcc tacagatgtg taatcaatgg agctgccgac aagcttttta atcatatctt 808441 ttttgttgtc atctgcgatg cccaccggcg taatgccgag attgtgaacg gcatccaaga 808501 atgaaagctc aagcacaacc acccgcttag gtgtgccgct tactgtcgtt tttccttctt 808561 cgtcatggat cactctggaa tccttagact cgcttttgcc gcttccgttg ttattctggc 808621 ttgatgaaca gccggataca atgaggcagg cgagcaataa aacactcatg atggcaatca 808681 acttgttaga ataggtgcgc atgtcattct tccttttttc agatttagta atgagaatca 808741 ttatcacatg taacactata atagcatggc ttatcatgtc aatatttttt tagtaaagaa 808801 agctgcgttt ttactgcttt ctcatgaaag catcatcaga cacaaataag tggtatgcag 808861 cgttaccgtg tcttcgagac aaaaacgcat gggcgttggc tttagaggtt tcgaacatat 808921 cagcagtgac ataaggaagg agagtgctga gataaccgga caatttcttt tctatttcat 808981 ctgttagtgc aaattcaatg tcgccgatat tcatgataat cgagaaaaca aagtcgatat 809041 cgatatgaaa atgttcctcg gcaaaaaccg caagctcgtg aattcctggt gaacatccgg 809101 cacgcttatg gaaaatctgt ttgactaaat cactcacaat ccaagcattg tattgctgtt 809161 ctggtgaaaa gtattgcatt agacatacct cctgctcgta cggataaagg cagcgtttca 809221 tggtcgtgtg ctccgtgcag cggcttctcc ttaattttga tttttctgaa aataggtccc 809281 gttcctatca ctttaccatg gacggaaaac aaatagctac taccattcct cctgtttttc 809341 tcttcaatgt tctggaatct gtttcaggta cagacgatcg ggtatgaaag aaatatagaa 809401 aacatgaagg aggaatatcg acatgaaacc agttgtaaaa gagtatacaa atgacgaaca 809461 gctcatgaaa gatgtagagg aattgcagaa aatgggtgtt gcgaaagagg atgtatacgt 809521 cttagctcac gacgatgaca gaacggaacg cctggctgac aacacgaacg ccaacacgat 809581 cggagccaaa gaaacaggtt tcaagcacgc ggtgggaaat atcttcaata aaaaaggaga 809641 cgagctccgc aataaaattc acgaaatcgg tttttctgaa gatgaagccg ctcaatttga 809701 aaaacgctta gatgaaggaa aagtgcttct ctttgtgaca gataacgaaa aagtgaaagc 809761 ttgggcataa agcaaggaaa aaaccaaaag gccaatgtcg gccttttggt ttttttgcgg 809821 tctttgcggt gggattttgc agaatgccgc aataggatag cggaacattt tcggttctga 809881 atgtccctca atttgctatt atatttttgt gataaattgg aataaaatct cacaaaatag 809941 aaaatggggg tacatagtgg atgaaaaaag tgatgttagc tacggctttg tttttaggat 810001 tgactccagc tggcgcgaac gcagctgatt taggccacca gacgttggga tccaatgatg 810061 gctggggcgc gtactcgacc ggcacgacag gcggatcaaa agcatcctcc tcaaatgtgt 810121 ataccgtcag caacagaaac cagcttgtct cggcattagg gaaggaaacg aacacaacgc 810181 caaaaatcat ttatatcaag ggaacgattg acatgaacgt ggatgacaat ctgaagccgc 810241 ttggcctaaa tgactataaa gatccggagt atgatttgga caaatatttg aaagcctatg 810301 atcctagcac atggggcaaa aaagagccgt cgggaacaca agaagaagcg agagcacgct 810361 ctcagaaaaa ccaaaaagca cgggtcatgg tggatatccc tgcaaacacg acgatcgtcg 810421 gttcagggac taacgctaaa gtcgtgggag gaaacttcca aatcaagagt gataacgtca 810481 ttattcgcaa cattgaattc caggatgcct atgactattt tccgcaatgg gatccgactg 810541 acggaagctc agggaactgg aactcacaat acgacaacat cacgataaac ggcggcacac 810601 acatctggat tgatcactgt acatttaatg acggttcgcg tccggacagc acatcaccga 810661 aatattatgg aagaaaatat cagcaccatg acggccaaac ggatgcttcc aacggtgcta 810721 actatatcac gatgtcctac aactattatc acgatcatga taaaagctcc attttcggat 810781 caagtgacag caaaacctcc gatgacggca aattaaaaat tacgctgcat cataaccgct 810841 ataaaaatat tgtccagcgc gcgccgagag tccgcttcgg gcaagtgcac gtatacaaca 810901 actattatga aggaagcaca agctcttcaa gttatccttt tagctatgca tggggaatcg 810961 gaaagtcatc taaaatctat gcccaaaaca atgtcattga cgtaccggga ctgtcagctg 811021 ctaaaacgat cagcgtattc agcgggggaa cggctttata tgactccggc acgttgctga 811081 acggcacaca gatcaacgca tcggctgcaa acgggctgag ctcttctgtc ggctggacgc 811141 cgtctctgca tggatcgatt gatgcttctg ctaatgtgaa atcaaatgtt ataaatcaag 811201 cgggtgcggg taaattaaat taagaaagtg aaaaacacaa agggtgctaa cctttgtgtt 811261 ttttaattaa ttaaaatgtt tattaactta gttaaggagt agaatggaaa aggggatcgg 811321 aaaacaagta tataggagga gacctattta tggcttcaga aaaagacgca ggaaaacagt 811381 cagcagtaaa gcttgttcca ttgcttatta ctgtcgctgt gggactaatc atctggttta 811441 ttcccgctcc gtccggactt gaacctaaag cttggcattt gtttgcgatt tttgtcgcaa 811501 caattatcgg ctttatctcc aagcccttgc caatgggtgc aattgcaatt tttgcattgg 811561 cggttactgc actaactgga acactatcaa ttgaggatac attaagcgga ttcgggaata 811621 agaccatttg gcttatcgtt atcgcattct ttatttcccg gggatttatc aaaaccggtc 811681 tcggtgcgag aatttcgtat gtattcgttc agaaattcgg aaaaaaaacc cttggacttt 811741 cttattcact gctattcagt gatttaatac tttcacctgc tattccaagt aatacggcgc 811801 gtgcaggagg cattatattt cctattatca gatcattatc cgaaacattc ggatcaagcc 811861 cggcaaatgg aacagagaga aaaatcggtg cattcttatt aaaaaccggt tttcagggga 811921 atctgatcac atctgctatg ttcctgacag cgatggcggc gaacccgctg attgccaagc 811981 tggcccatga tgtcgcaggg gtggacttaa catggacaag ctgggcaatt gccgcgattg 812041 taccgggact tgtaagctta atcatcacgc cgcttgtgat ttacaaactg tatccgccgg 812101 aaatcaaaga aacaccggat gcggcgaaaa tcgcaacaga aaaactgaaa gaaatgggac 812161 cgttcaaaaa atcggagctt tccatggtta tcgtgtttct tttggtgctt gtgctgtgga 812221 tttttggcgg cagcttcaac atcgacgcta ccacaaccgc attgatcggt ttggccgttc 812281 tcttattatc acaagttctg acttgggatg atatcaagaa agaacagggc gcttgggata 812341 cgctcacttg gtttgcggcg cttgtcatgc tcgccaactt cttgaatgaa ttaggcatgg 812401 tgtcttggtt cagtaatgcc atgaaatcat ccgtatcagg gttctcttgg attgtggcat 812461 tcatcatttt aattgttgtg tattattact ctcactattt ctttgcaagt gcgacagccc 812521 acatcagtgc gatgtattca gcatttttgg ctgtcgtcgt ggcagcgggc gcaccgccgc 812581 ttttagcagc gctgagcctc gcgttcatca gcaacctgtt cgggtcaacg actcactacg 812641 gttctggagc ggctccggtc ttcttcggag caggctacat cccgcaaggc aaatggtggt 812701 ccatcggatt tatcctgtcg attgttcata tcatcgtatg gcttgtgatc ggcggattat 812761 ggtggaaagt actaggaata tggtagaaag aaaaaggcag acgcggtctg ccttttttta 812821 ttttcactcc ttcgtaagaa aatggatttt gaaaaatgag aaaattccct gtgaaaaatg 812881 gtatgatcta ggtagaaagg acggctggtg ctgtggtgaa aaagcggttc catttttccc 812941 tgcaaacaaa aataatgggg ctgattgcgg ctctgctggt ctttgtcatt ggtgtgctga 813001 ccattacgtt agccgttcag catacacagg gagaacggag acaggcagag cagctggcgg 813061 ttcaaacggc gagaaccatt tcctatatgc cgccggttaa agagctcatt gagagaaaag 813121 acggacatgc ggctcagacg caagaggtca ttgaacaaat gaaagaacag actggtgcgt 813181 ttgccattta tgttttgaac gaaaaaggag acattcgcag cgcctctgga aaaagcggat 813241 taaagaaact ggagcgcagc agagaaattt tgtttggcgg ttcgcatgtt tctgaaacaa 813301 aagcggatgg acgaagagtg atcagaggga gcgcgccgat tataaaagaa cagaagggat 813361 acagccaagt gatcggcagc gtgtctgttg attttctgca aacggagaca gagcaaagca 813421 tcaaaaagca tttgagaaat ttgagtgtga ttgctgtgct tgtactgctg ctcggattta 813481 ttggcgccgc cgtgctggcg aaaagcatca gaaaggatac gctcgggctt gaaccgcatg 813541 agatcgcggc tctatatcgt gagaggaacg caatgctttt cgcgattcga gaagggatta 813601 ttgccaccaa tcgtgaaggc gtcgtcacca tgatgaacgt atcggcggcc gagatgctga 813661 agctgcccga gcctgtgatc catcttccta tagatgacgt catgccggga gcagggctga 813721 tgtctgtgct tgaaaaagga gaaatgctgc cgaaccagga agtaagcgtc aacgatcaag 813781 tgtttattat caatacgaaa gtgatgaatc aaggcgggca ggcgtatggg attgtcgtca 813841 gcttcaggga gaaaacagag ctgaagaagc tgatcgacac attgacagag gttcgcaaat 813901 attcagagga tctcagggcg cagactcatg aattttcaaa taagctttat gcgattttag 813961 ggctgcttga gcttggggag tatgatgaag ccattgatct gattaaagag gaatatgcga 814021 tacaaaatga acagcatgat cttttattcc ataacatcca ttcgcagcag gtgcaggcca 814081 ttttgttagg gaaaataagc aaggcatcgg aaaagaaggt caagctggtg attgatgaga 814141 acagctcact cgcgcctctt cctgcgcata tcggcttgtc ccatcttatt acgattattg 814201 gcaatttaat tgataacgct ttcgaagctg tagcggagca aagcgtgaag gaagttttgt 814261 tttttatcac ggatatgggc catgacattg tcattgaagt atcagacaca gggcccggtg 814321 tgccgccaga gaaaatagaa gctgtgtttg agagaggcta ttcttcaaag gggatgagga 814381 gaggctacgg tctggccaat gtgaaagact cagtgcgtga actgggcggc tggatcgaac 814441 tggcgaatca aaaaactggc ggggcggtat tcactgtatt tataccgaag gagaaacaaa 814501 gggggaatcc atttgattca catcgcgatt gcggaggatg attttcgagt tgcgcaaatc 814561 catgagagat tgattaaaca gcttgatgga ttcaagatta tcggcaaggc ggctaacgca 814621 aaagagacat tggcgctttt gaaggaacac aaggctgatt tgcttctgct ggatatttat 814681 atgccggacg agcttgggac cgcgttgatt cctgatatac gaagccgatt tcctgaagtg 814741 gacattatga ttatcacagc ggcaacagaa acccgtcatt tgcaggaagc gctaagggcg 814801 ggaattgccc actatttgat caaacccgta acagctgaca agttcaggca ggtgctgctt 814861 cagtataaag aaaaaaggaa gctgctcatg tctcagccgg aggtcagcca atccatgatc 814921 gaccatattt ttgggaacgg tgtgaagaca gctttgccgg cagaggattt gccgactggc 814981 attaattcga ttacactgcg aaaaattaag gaagcgcttc agactgcgtc agaaggattg 815041 acagcggagg aacttgggga aaaaatgggg gcgtcacgaa caactgcccg ccgttatgcc 815101 gagtaccttg tgtcaaagga agaagcaaga gccgagcttg aatacgggat tatcggcagg 815161 ccggagagaa aatattattt ggcggcggat tagatatgaa aaaatctata atcctattga 815221 atattctatt gatctttatg cagggtgata tcaggcaggc ggctgcgccg cgcctgccgg 815281 acgggccgat agaaattgtc gtccctgccg aaccttctgg cggctgggat gtcacagcgc 815341 aggcgatcca atcagttttg aggcagaagc agatcgtgaa ggatgatgtt catatcgtct 815401 ataaatccgg cggcggggga gagaaaggct ggaaatatgt caacaaaagc agcaaacaaa 815461 ccatcagcat gacgtccagc ctaatattga gcaatgatct tctcgggcaa agcaaattaa 815521 aaatgtccga ttttacgccg ctcgccattc tctccaagga atggcagacg gttgcattgc 815581 caaaaggatc agcgttaaca aatggcaagg atgtgctgaa tgagatcaac atgcatcccg 815641 gcaaggtgag aatcggcttt gccccggggt ttggcaatga tgatcagctc tcgttcgtca 815701 gagcggcaga tatgtacggc attgacccgt ttgacattca attctcacag tatgacagca 815761 gcgaacagct cattcaggcg ctgatcagac atgagataga agcggcttcc atgacacttt 815821 ctgaagcgaa accatatgaa cgaaacggcg atatcacgtt agccgctgta acgtctgata 815881 aaagacttcc cggttttcca aatgtaccga cgtggaagga gcagggaatc ccgtttgttt 815941 tttctcattg gagagggatt ttgggcccga aaaatatgtc tgaggaagag atttcttact 816001 gggatcaagc gctaaagaag gtcacctcct cacctgaatg gaagcggaaa ataaacgaac 816061 aggactggga aagcttttat ttaaacagca gggaaacgaa acggttttta gaagagcaat 816121 ctgcttttta tcaaagcatc atgacaggaa attaaaatcc cgacatcccg ggattttttt 816181 catgccgaaa attgatcaaa aagaacaaaa cggttttaaa aaattaaaaa tacaaaaaaa 816241 ccaaattatt tacttgcggt tggttttccc atacgatggc aaaaaggcaa gacaaaaagg 816301 ggagtaaggg agaaaaaaat gtaagcggat tcatttaagg gggaatggat gtgttagcaa 816361 tcttaggctt tctcatgatg cttgtgttta tggcattgat catgacaaaa cggctttctg 816421 ttttaacagc attagttttg acgccgattg tgtttgcgct tatcgccgga tttggattta 816481 ctgaagttgg ggacatgatg atttcgggga ttcagcaagt cgcgccgact gcggtcatga 816541 ttatgtttgc gatcttatat tttggaatta tgattgatac aggcctgttt gatccaatgg 816601 ttggcaaaat tttaagcatg gtcaaaggag accctttaaa aattgttgtc gggacagcgg 816661 ttcttacaat gctcgtcgcc ttggacggag atggctcgac aacgtacatg attacgacaa 816721 gcgccatgct tccgctctat ttgctgctag gcatccggcc aattatcttg gcaggaatcg 816781 cgggagtcgg catgggaatc atgaacacga ttccatgggg aggtgcgacg ccgagggcgg 816841 cgagtgcgct gggggttgat ccagctgagc ttacagggcc gatgattcct gtcattgcaa 816901 gcgggatgct ttgtatggtg gcagttgcgt atgtgcttgg aaaagcggaa cgaaagcgcc 816961 ttggtgtgat tgaactgaaa cagccagcca atgccaatga accggctgct gcggttgaag 817021 atgagtggaa gcggccgaag ctttggtggt tcaatttatt gttaacgctt tctttaatag 817081 gatgtttagt atcgggtaaa gtcagtttaa ccgtactgtt tgtcattgcg ttttgtattg 817141 cgctgattgt gaattatccc aatctcgagc atcagagaca gcgcatcgcg gcgcattcca 817201 gcaacgtgct ggctatcggt tcaatgattt ttgctgcggg ggtgttcacg gggattttga 817261 caggcacgaa aatggttgat gaaatggcga tctcgctcgt gtccatgata ccggaacaaa 817321 tgggcggatt gatcccggcg attgttgcct taacaagcgg cattttcaca tttttgatgc 817381 cgaatgacgc gtatttctac ggggtgctgc cgattttatc agaaacagct gtcgcatacg 817441 gtgtggataa agtggaaatt gccagagcct ctattatcgg ccagccgatt catatgctga 817501 gtccgcttgt gccatccact catttgcttg tcggactcgt cggagtttct attgatgacc 817561 atcaaaaatt cgcattgaaa tgggcggttc tcgcagtgat cgtcatgacg gctatcgctc 817621 tattgatcgg tgcgatctct atttccgtat gataattcag gcgtaatgac acacactaac 817681 ggcatacaac attccggagg tgtcattatg agtgatcctt atatgccgct gacttcagtc 817741 agaagcggag cggggttcga agcggcaaaa ggggtgcacg gcctgactgt gcaaattgcg 817801 aatgtctatt ttattcagct gccttctgaa cctcactcat ttgttttaat tgatgccggc 817861 atgccccaat cagccggcgt gattgtcaat gaagccaaac aaagattcgg tgaagggttt 817921 cagctgaagg cgattatcct cacacacggg cactttgacc atattggggc aatcgaagag 817981 atccttgagc attgggatgt gcctgtttat atccattctc gggaaatgcc ttatgtaaca 818041 ggtaaagagg attatcctcc ggctcgtcct gacagcaaga gcgggctggt cgctaagctg 818101 tcgccgctgt ttccgcggca ctctatcgat atttcctcac atgtccaggc actgccggaa 818161 gacggttcag ttccttttct tgacgagtgg atgtggatcg cgacaccagg acacacgccg 818221 ggccatattt cgttattccg cgatgacggc cgcgtgcttg tggcaggtga tgctgttatt 818281 acagtggaac aggagaaaat ggctgacgtc ttgatacaaa aacaggagct tcacgggccg 818341 ccggcttatt tcacgcctga cacagagacg gccgctgagt ccattctaaa gctggccggt 818401 cttgaaccgg aagcgttatt gaccgggcac ggcataccga tgaccggcaa aaactttcga 818461 agtgacttaa ctgaattggc aaatcggtta tcgtctattt gacacccgca ccacgcgggt 818521 gttttttatt gttttccagg aagttgcaga aaaatcattt gtcttgccgc ttaaaaacga 818581 tacaatgaaa agcatgaagt gatgtgaagg ggagagtttg ttggaagaaa aagaaatact 818641 ctggaacgaa gcgaaagcgt ttattgccgc atgctatcag gaattgggaa aggaggagga 818701 agtgaaagac cgtctcgcgg acattaaaag tgaaattgac ctgaccggaa gctatgtaca 818761 tacgaaggaa gagctggagc acggagcgaa aatggcttgg agaaacagca accgctgcat 818821 cggcagattg ttctggaatt cgctgaatgt tatcgacaga cgagacgtcc ggacgaagga 818881 ggaagtgcgt gatgccctct ttcaccatat tgaaaccgcc accaataacg ggaaaatcag 818941 accgaccatt acgattttcc ctccggaaga gaagggtgaa aagcaagtcg agatctggaa 819001 tcatcagctg atccggtacg ctggatatga gtcagacgga gaaagaatcg gcgacccggc 819061 ttcctgttcc ctgacagcag cctgcgaaga gctcggctgg cgcggagagc gaacggattt 819121 tgacctgctg ccgctcattt ttcgcatgaa aggggacgag cagcctgtct ggtatgagct 819181 gccgcgttca cttgtgattg aggttccaat cacacatccg gacatcgagg cgttttctga 819241 tttggagctg aagtggtacg gcgtgcctat tatttctgat atgaagcttg aggtcggggg 819301 cattcattat aatgccgcgc catttaacgg ctggtatatg ggcacggaga tcggagcgag 819361 aaacctcgca gatgaaaagc ggtacgacaa gctcaaaaaa gtagcgtccg tgatcggcat 819421 cgccgctgat tacaatacgg atttatggaa ggatcaagcg ctagttgaat tgaataaagc 819481 tgtgctgcac tcgtataaaa agcagggtgt cagcatcgtt gaccatcata cagcggcaag 819541 ccagtttaaa cggtttgaag aacaggagga agaagcgggc agaaagctga cgggggactg 819601 gacgtggctg attccgccaa tttcacccgc tgccactcat atcttccacc gctcctatga 819661 taactcaatc gttaagccga actattttta tcaagataag ccttatgagt aaacaataga 819721 aaatcgatga tggccttcaa ggctgcggga ttcagtcaca gagatgtcgg taacctttga 819781 gaaagggctt ccgttcttta cagcctcaac aaacgattgc agggcgtttt ccggaccctc 819841 tgccaaaatc tcgacacgcc cgtcatcacg gtttttgacc cagccggcca gttttcgctt 819901 atcagcttcc atttgaacaa aatagcgaaa gcccacacct tgaacccggc cgtctacaat 819961 gattcggtat tgaagcatgt aaaaaccacc ttttcttttt atgataatca atcattttac 820021 aacctgtaaa ggggatgtgt ttgtatgaaa caagagcgct attcagttct ttctcttaat 820081 ctgggaaaac cgcagacgct tgaatatgac ggaaagaaaa tcgaaaccgg catcatgaag 820141 cggccggcta aatcagccgt catgctgtat cgggagaatt ttgaaggaga cggacaggcg 820201 gacctcgtca accacggcgg acctgataag gctgtctgtg tctacccggc ggagcattat 820261 ccgttttggg aagagttcct ctcaagaccg ctgtcaaatg ccgcatttgg agaaaatctg 820321 acggtcgcgg gcctgactga ggagaatgtt tgcatcgggg atgtgttcag acttgatgaa 820381 gctgttgttc aggtcagcca gccgcgccag ccgtgtgtaa agctggcgaa aaagtttggt 820441 gtaaaagaaa tggtgctgaa ggtccagcaa accggctata cagggtttta ttttcgcgtg 820501 ctggaggagg gcagggtgtc tcccggcgcg aaccttgaat tgctgtccag aggagagaaa 820561 ggcatatccg tccagttcgc gaaccgcatc aactaccatg atgcaaaaaa tctcaccgcc 820621 attgaacgga ttttaagtga ggctgcacta tcggaaagct ggagagcgtc ctttatgaaa 820681 aaaaaggaca ggctgctgcc ggttgaatag aaaaaagccg cgcatatcaa cgtgcgcggc 820741 tttgccatat ttaagattgt tttttctttg attcaagcag gttggcaaga aaataggttt 820801 tatagctttg aagctttctt ccttcatggt gcgtgatccc ctgctttttt agttctgcca 820861 cataccagcc tttactgccg taatgcatgt cagaaaactc ctttccctat ctgatttcga 820921 aacgattggc attgtaacat ctataaaaag atgctgaaaa gagatgcggg gaaaactgag 820981 cctttcgcac tagatgtacg aatgttcttc tgaatgtata tgcggagcaa aagccgaata 821041 tgatttaatg gccggttagt ttgatcatga caacgccaaa tgtcataatg gcgaaaacaa 821101 tgccgatata tgtgagcatc ccgttttttt tcttaacgcc gtaaacggtc ataatgatgc 821161 cttcaatgaa aaaaatgatg ccgaaaataa taaaccacat gcagataaag gctcctttca 821221 cagacataat agtagtgtag catatctgaa agagccgggc tgtgacaata tcaagaaagc 821281 cgggcgcata tcgcccggct catgttttat tgtttatcaa ccaatttgac cagaagctgt 821341 gccaaatgtt ctttctcatc ttcgtctgca acgctccaaa gctcttgcag cagcatttct 821401 tcaccgtttt gcggctcttc atgctttgcg aggtagtctc ccaggatcgc agcgcttttt 821461 acaagcttgc cgtcatccaa tcccagcttt ttgcctcggt tgacttgttt tttcaggtag 821521 cctttaaatt cctcaaagtc ttttaaaatg tcttctttta ttgtgccatg catcgcgttc 821581 atttcgtttt caatttggat tttttcttga tctctgttca ttgcaagacc tcctcgtaca 821641 gaataatgat gctttacctg caattggagg aggttaaacc tgccggaagc ccggaatgtg 821701 ttttacagtt tcgtcaggat aatcggttca tcttttgtga tgacgatcgt gtgttcaact 821761 tgggcaacca tgcttttatc cggcgtcttg aacgtccagc cgtctccagc ttcaacaatc 821821 gtttctgctt tcgttgaaat aaacggttca agcgcgatga ctgtgccatt tttgaacagc 821881 gcattatcaa acggatcata atagttcatg atgtggttcg gcgcttcatg caggcttcgg 821941 ccgattccgt ggccggtcag ggttttgatg acggtaaagc cttgagagcg tgcttcatga 822001 taaacggctc ttccgatctg gttttggcgc ttgcccgctt ttgcctgctg aagccccttt 822061 tgaaaagcgt tttccgcgca ttggcaaagc ttatgaaggc gttcttctcc ttcaccgagc 822121 acaaatgaga tgcctgtgtc ggaatagaag ccgccaaatt cagcggagat gtcgatgttg 822181 acaaggtccc ctgcttttaa aattttggat gtgcttggta tgccgtgagc cacttcatca 822241 tttacgctga tacatgtcac acctggaaaa tcgtattcct tctcaggagc tgaaacggcg 822301 ccgtgctcat caagcacagc ttttccgata aggtcaaggt cttttgtgct catgccgggc 822361 tctgccttcc gcttcatttc ttcacgcgca agcgcgacga ttcttccgat ttttttcagg 822421 ccttctaatt cttgatcgtt tgttacaatc atctgtcatt cccgctttct ttttaaataa 822481 tctagattaa gcttaccaca actgtcttaa aaataggaaa cacacggacc tgggaaaaaa 822541 gaaatacccc cgggaaaatt ggtatagatc actagatatc ttatatggta tatttgaaaa 822601 aaaagggtat gagggggatg ggtatgcttt catttttaca aaaactcggg aagtcattta 822661 tgctcccgat tgcggttctg cctgcggttg gaattatcct tgcgcttggc agagaggatg 822721 tatttaatat cccgtttgtc tatcaggcgg ggacggcggt ttttgatcat ctgccgctta 822781 tttttgcgat cggtattgcc atcggcattt caaaagacag caatggggca gcgggtttat 822841 caggggcgat atcgtatctg atgcttgacg cggcaacaaa gacaattgat aaaacaaata 822901 acatggcggt gtttggggga attattgccg gtttaattgc cggttacacc tataaccgct 822961 tcaaggatac caagctgcct gaatatctcg ggttcttcag tggcagacgg cttgtgccga 823021 ttttaacagc cattattacg atcattttag cgggcatatt cggagtggtc tggccgccga 823081 ttcaatcgtg tatcaactcg tttggagagt ggatgctcgg gctcggcggc atcggggcag 823141 gcatattcgg cctattcaac aggctgttaa ttccgcttgg ccttcaccat gtgctgaaca 823201 atattttctg gttccaattc ggagaatata acggagtgac aggggatttg gcgcgctttt 823261 tcgcgaaaga tccgactgcg ggcacatata tgaccggatt tttcccaatc atgatgttcg 823321 gtcttccggc ggcgtgtctg gctatggttg tgactgcgaa gccgtctaaa cggaaagcga 823381 cggctggaat gatgattgga tttgctttaa cggcgtttat cacagggatt acggagccga 823441 ttgagtttgc atttatgttt ttatctccgc ttttatacgc tgttcacgcg gtcttaaccg 823501 ggttatcttt atttatcgtc aactggctcg gcatccgctc aggcttctct ttttcagccg 823561 gagctatcga ttatgtgctc agctatggaa tcgcggaaaa accgctgctt ctgcttttgg 823621 taggtatatg ctatgcggca gtatacttta tcgtgtttta tgtactgatt aaggctttga 823681 atttaaaaac gcctggacgg gaagacgatg atgtggatga agtgctggat gaaaatactg 823741 ttcaggatgt aaatgaaaac atcatgctga aagggctcgg cggaaaagaa aaccttcaaa 823801 ccattgatca ttgcgccaca aggctgcgac tgactgtgaa ggataccgct ttggtggatg 823861 aagcactgct aaagaaagca ggcgcaaaag gggttgtcaa atcgggcggg caatcggttc 823921 aagtcattat tggcccgaat gtggaatttg cagctgagga attgagggct gctgtcaaat 823981 aaaaaagcgg agagggcaac ctctccgctt tttcttattt atcttcgtta tcctttgacg 824041 tttcggaaga atcttcgtca tgttttgtgt aatcataatc agaaggattc accttcttaa 824101 aacctttcgg ctcgtagaac cgcagcaggt ctccgtttat gattttatcg gacatttcaa 824161 gttccttctt gacgagtgag tcttctgact tgtcgacttc ggattcatcg agttcttttc 824221 cggttttcgt gtcgtaatac ttaccggata ttttcgtgta cttcggtgaa ataaagtctc 824281 cgtttcggaa cggaatcact tcacggtgtt ctttcgataa aatatcagaa ccggacatca 824341 gatagtcctt cgtatccact ccgagcagat gcagaatggt aggagccaca tcaacgtctc 824401 cggcatattt atgaactttc tcgcccttca cgccggcagc gtggataaag agcggcaccc 824461 gttgaagctg ggcgttgtcg taatcagtga tttcatcctt gccaagcact ttcgccatcg 824521 ctttattgtg gttttcagag atgccgtagt ggtctccgta catcacaata atcgatttat 824581 catataaccc gtcttttttc agatcattga agaattgttc aatggactga tcaaggtaat 824641 gggctgactg gaaatagtta tcgacgacag agtcaccaaa gtctccagcc gggaagtctg 824701 tatccccctc atccattccg aatgggaagt ggttggaaag ggtaatgaac ttcgtataga 824761 acggctgcgg caggctttcc agcagcggca ttgattcttt gaagaacggt ttgtctttca 824821 tgccgtagtt tttcgtgttt tcttcgttca tgtcatagta agcagaatca aagaatttat 824881 caatgccttc cgccttgtac atttcgttac ggttccagaa cgtctgcgtg ttcccgtgga 824941 aagtagcaga tgtgtaattc ttagacttca gaatcgccgg aacggattgc agcgtgtttt 825001 gcgctttgtt tacgaaaact gaaccttgag ccagcgggta cagagagttt tccatcataa 825061 attcagcatc agatgtttta ccttgtcccg tttggtggaa aaagttatca aagtagaacg 825121 tttcgttatc atgtgccagt ttatttaaga atggtgtcac ttctttgccg tcaattttat 825181 agtcgatgat aaatgactgc aaagattcaa gtgaaacgta aatgacgttt tttccttccg 825241 ctttgccgaa atacacgtta ttcggcacat cgtaattggc tttcatgtag ttttctactt 825301 ccgttacgtc gctggaatcg gcaagcgcgc gctggctgtt ggacttgata ttctgtacag 825361 cgtcataaat cgtgaaattg tatgttccca agtatttcac aagatagttc cggtcgaatg 825421 atcttgtcag caattcagga cggtctgatt ccgcaactgc caggttgatc aagaacacaa 825481 gaattgaaga cgcaaaaata attcggaacg attttttgct tgacgtttcg gcaggcttgt 825541 ttactttgat cgccaagatg atcaggatga tcgtatcgat aaagtaaaag gcgtcagtcg 825601 gtctcatcag cgaaaatgcg ctgtcaccga gttggccgcc gtttgtttta gcctgcataa 825661 tgaccggaat tgtaataaaa tcattgaaaa atctgtagta cacaatgttg gcgtacagta 825721 aaaaagacat taaaaaatga atcactataa tggctgtctg ctgtaatttt ttcttgaaca 825781 agagtccaaa gccaagaaag aacaagcttg agctaagagg attcacaaaa agcaatattt 825841 tttgtatcgt gttgtctatt cctaagttga aattcaggac ataaccgaca tacgttttga 825901 tccataacag gacgaccgca attaagaaga aggccagtcc tctttctttt ataaatgttt 825961 tcattgttac actccttttt tccgatccag ttcgagcgaa acgatagaaa aaacgaacgt 826021 atccaatata acacgaatca gcagattaga aaagtgaaaa tcgtatgagg gagaaagtgg 826081 cgaaaaacgc cgtcgaatca acgtttcgct ttgatattac caaatgtaaa acaaggtatc 826141 tttctagaaa taaaggaata aaatggtaca ttgagaattg tatgataaaa tataaggtat 826201 agataaaaag aggtgaaatg atggattttt cccatattgt gtctgaagat aaaattaagc 826261 gcgccatcaa agacggggac tttcaaaacc tcccgggaat ggggaagccg ctgccgaagg 826321 atgacgcggc acacttgccg gaatcgctgc gcatgggcta tcgtattttg aaaaacgcgg 826381 gaatggcaga ggacgagggc gcgctcaaaa aagagcttat gaccatcgac catttaatcg 826441 aaaagtgcta tgacgaaaaa gaacgcgagc aattaatcag aaaaaaatct gaaaagcaat 826501 tgctgcttga taagcttgtc gacaaaaaag gcatgttttc aaagccagca tccgcttttt 826561 ataagaataa agtatatgac cggcttggac gaaacagacc ttcttccagc tgatttgtct 826621 tgtctgcagg atggcgattg ataaaagcca tcctttttat gttccaagtt ctatgtcaaa 826681 aggtttatgt ttttccatct atgggaaatg attcataaac gaaaaaaggg tgatgggatg 826741 gaacgactat tagtatggat agagcatata tctgattggc tgtggggtcc gccgctaatc 826801 atcctgctga cggggacggg cttgtatttc actattttgc tgaaaggttt tcaatttcgc 826861 tatcctttat acattttcaa acagacaatc ggcagtgtag gaaaaaagcc gaagggagaa 826921 ggcacagtca caccgcttca ggcattgacc tcagccctca gttcaacgat cggtgcagcg 826981 aacattgtcg gtgtgcccgc cgctattatg tttgggggac caggagcggt tttttggatg 827041 tggcttattg ccttatttgc catggcgatt aagttttctg aaagtgttct tgctgttcat 827101 tacagagaaa aaaatgagca gggtgaatac gtcgggggac cgatgtatta cataacaaaa 827161 gggctgcgca tgaaatggct cggcgtattc ttctctgttg cgctgattgt ggagctgatt 827221 cccagcatta tggttcaggg aaattcggtt tcagtctcgc ttgccgagac gttttctttc 827281 aataaaatat acgcaggaat cggaattgca tttttgattg ggttagtggt gataggaggg 827341 gtaaagcgga tcggaaaagt aacagagttt gtcgtgcctc ttatggcagg ggcatacgca 827401 ggtgccggtc tcctgattgt tctcatgaat ctatcatcag tgccggcgtt tttctctctc 827461 gttttttcaa atgcgtttac ctcttcttca gcagttggag ggttcgcagg tgctgcgttg 827521 gcggaaaccg ttcgctgggg atttgcccgc gggctgtatt ctaatgaagc cgggatggga 827581 acagccccga ttgcacatgc ggcagcaatg actgatcatc ctgtgcggca agggttttgg 827641 tctgtgatcg gcattgtcat tgacacctta atcatctgta cgactaccgc ttttatcgtc 827701 cttgcatccg gtgtatggac agggaagaac gcctcaaatg acccggcagc actgacaacg 827761 gccgcatttc agcactattt cggttctgga ggaggatact tcgtttcggt ttccctggtc 827821 ttctttgtcg tatcaaccat tatggttgtc attttttacg gcgtaaagca agctgaattt 827881 ctgttcgggc ggctggcagg acatgtgatt aaattcgttt atttagcggc tattatcata 827941 ggtgccgcag gcggagcaaa agccatttgg ggcgtattgg acttagcatt ggtttttatt 828001 gttgtcccga atgtgattgc gctcttgtta ttgagcagaa aggtaaaagc gctgtacacc 828061 gaattcttta catctgaaca gtactacctg aaagatataa gaaaaacgaa acaaaagcct 828121 gtttatccaa caaaagaagc taaaaattcc tagtgttttg cttttgcgcc gaacaatgct 828181 ttgcttttta tgatcaaata aatgagtaaa ggcagcaaaa gagaaatcac tacattaatg 828241 attggtttga ttctgttaaa gtcgattagc tgatttgtat ttaaaaaaaa ccaaaagccg 828301 catacgactg agaacatgcc ggttggtgta tacatggctt tcgggtcgat ttttgagtgt 828361 aaaaacgaaa ggccgtatac cacgatatat agggaacctg ctatcttcac cataatgacc 828421 ggaatccaaa aagccgcgat gatcaggtct gagcgatcca gaaaatccgt aatgcggatc 828481 tgcctgatga ccatataagc aggatcaaag aaagtagatg tcaggttggg accaaagaca 828541 gaaattgaag aaaataacat cacggccagc aataaagcgc ccagcagtat cgcgaaaatg 828601 gtgtatttta gcgggacgct ccggtttgag aagagaagcg gaaggataat caattccccc 828661 attgtcccaa acgcgtaata gcctgattga aggtatggga ttagaccttc aaaaacaggt 828721 gtcaagtttt gaagctcaat ttgtgtggcc agcgtaaatg gaaggaacaa gaccaggatg 828781 ccgaatggaa ataggaatat ctgcgccatt ctggtcaatg tttcttttcc ctctctggca 828841 atacagatcg ccacaaagat aataacaccg ccaagaacag ccattggtgt tctcgggaga 828901 aataaaatgt taatcaaatt gatgaaaaaa cgtatatcat gagcattgat taacaggaaa 828961 tacaaagaaa acagtaaaat gataatccgg cctgcgattg gtgaggaatc gctcagcagc 829021 tcatagatat ttttatcctg atgctttttc atcagcctat gcatgagcca gagtgccgga 829081 atcacgatga caacgccgag gatgtagctg tgccaggcat tttgttttgc tgattcgatc 829141 atgagaatcg gagcatgctt taatccgact gctaacgtat acagagctcc gaaaaataat 829201 ccttggtatg cagaggtctt gtccataaag cacatccttt ctgtcatgtt caaaacggaa 829261 tatatttaaa caggtgcccc agccgcggaa gcaggggatt cactctcata taaatccata 829321 gaaaagcact tcctgcaatt agcaggctga aggcccattt tgttagattg ttagcggaac 829381 gaaaattctt ccattcatat gcgtatatgg caatgcacac aatcaatgtc tgtacgatat 829441 agctgatcat gctgacgcac ctccattaat ggctgatcgt tttgtatagg acaccgccct 829501 gctcaatcgt cacaattggg acgacgtgaa cctccatatc cttatatacc tcttcccatt 829561 cctttttcag cagattcttc gtggttgccg tgcttctgat ggtcctgtct tgaaagccgg 829621 ccgggtccgc ctttagcttt tgcaaacgat gaacggtgct gatcacgtcc ttctttatgg 829681 ttctgtttaa tgctttttga atgatgtaat actggtcatt ttctctcgtc tcataggttg 829741 attggttttc cataataatt cctttggctc tgatctcgat tgtcattgac agctttccgt 829801 ttttttcagc ggcatgaaag gatgcattgg acttttgaag ctgaatggat gcttgcccca 829861 tttgattcgg caggtctact atgaattctg gctggcgggc ttgattcagc aacatcaggg 829921 ctgctgtcat gtgttcatct ttgaaaatat ccatcaatct gtccttttta aagatcgcaa 829981 gcccgtcaat tttcaaatta gatttgcctt tccctccagg ttttgtttta gatgcagaga 830041 tgaccggtgc atacggatca ctgcctattt ctactagatc agacatgaat ctgcttaaga 830101 aaacggggcg gctcgttgcg ataatggcca gctcccgaat catttccgcc ggaaactgtt 830161 caagctgaac atcggtattt aaaatgtccc gcgcttctcc ccggctgact aaaatgagcg 830221 ccgttaatct gttctgcgga tttcgcgtta aaatatcaaa gactggggca acgccgtctc 830281 tcgccatatc ctctccaata atgactgtac gtctgtggga cgtattgatt gtccgtgaca 830341 aggaggtttg cagcttgttg ttcgcttctc tgatcgtagt gccggaagct gaatcaacat 830401 accatgtttt tgaaccggca gttccgccgc cgccccctgt ttgtccgcct aattggccga 830461 ccaagggaat ctgcatggcc actcgatact gatctttttt cttatcaatg gctgagctga 830521 caacaaatgc aatgtcattg atttctgtcc ggtcccagca ccccgttaga aggatacaaa 830581 tgagaagcgg caaaacacac ttatatattg ttttcttcat cttttgggtc ctctcttttc 830641 gctcccttct gtccgttgcc gcgcgaatac gtgcccggcc ttctggtcat cgtccaccaa 830701 ggcgccctga caaaaatatc ttttacttca tctcgtttaa acggagaaat cccggataaa 830761 taaggaatgc cgaaagattg cagcttgcat aaatgaagca ctaagataat cgtgccgagc 830821 ataatgccga atatcccaaa aatactcgcc aaaaacataa gcgggaaacg aagcatcctg 830881 atggagatag ctaagttaaa ccgcggaatt gtaaatgacg cgatccctgt taacgatacg 830941 atgatcacca tgggggcaga cacaattccc gcttcaacag cggctgtccc aatgactagg 831001 gccccgagaa tactgacggt ctggccgatg gttttcggca ggcgcactcc cgcctcacgg 831061 agagcctcaa aagaaatttc cataatcaat gcttctatga tggcggggaa aggaatcggt 831121 tcacgcgcag aggccacact gaacattaag tttgtcggca ttaagtcctg gtggtatgta 831181 ataacggcaa cataaatagc cggcaaatat aaagcaacga ataaaaacat atagcgaagc 831241 cagcggatta agttagacat caaataacgc tcatagtaat cttcactggc ctgcataagc 831301 tgccaaaacg taatcgggcc tgttaagaca aagggcgtat tatctgtgaa aatggcaaat 831361 cggccttcga gaagctgggc ggcgacggtg tccggccttt ctgtgtattg cagctggggg 831421 aatggcgagt acgtgtcgtc ttcgataaat tcttcaatat atccgctttc taagacagca 831481 tcaatcttta tctttttgat tctttttttt gctttgtcaa taacctttgg atcggcaagc 831541 ccgtcaatat aggccaagac aacatcggtt ttggttttcg tgccgatttt aaaagagatc 831601 attttaagct gaaacgtttt gacgcgaaag cgcacaagag cggtattgac cctgaggctt 831661 tcagtgaagc cctctcttga ccctctgatg gtcgattctg ttatcggctc ttcaatgctt 831721 cttctttgtc cgccttttat atttaagatc aggccttttg agtgcccgtc ggcaaataaa 831781 accgcgttcc cctcaatgat ggatgcagcc actttgctca tactcgtttc taatgcaaca 831841 cttgaaattg atagagtatt ttgcagcgcc tcttcatgtt catctatttg atccgtcaaa 831901 tgcattaaga aagggcggag ggcgtgatcc tgaatatgtt cagattttac aattccttcg 831961 atataaacaa taaatccgca cagcccgttt ccaaagtcaa attgtctaaa tacgatgtct 832021 gagcagcctt ctgttaataa ggtcagattt tcgaggtttt ccttcaaatt gggagagatc 832081 ggtctgtcct gattgtcttc aagctctttg atgagctgaa gcgctttgtc gcgtttattc 832141 atagaggctc accctgcttt ttaatgtcat attcaataag tgcttgtgac ttttagggta 832201 accttgtctg tttcatatat tccagactag gatgaaagcg ctataaaaaa gtgttgacta 832261 cctgtatata caggaataca atatgattat aagttgtata tacaagttat aaaaacggat 832321 acggaggggt tggcatgggg gaactgaaca aatcggcacg tcagattgtc gaagcagtcg 832381 gcggtgctga aaatattgca gcggcaactc attgtgttac acgtttgcgt tttgctttaa 832441 tagatgaaag caaggttgac caagagatgc ttgatcaaat tgatgtggta aagggatcat 832501 tctcgacaaa cggacagttt caggtcgtaa tcggccaggg aactgtcaat aaagtatatg 832561 ctgaactggt taaggaaacg gggattggcg agtcaacaaa ggatgaagtg aagaaggcct 832621 cagaaaaaaa tatgaatcct ttgcagcgtg ctgtgaaaac gcttgcagat atttttattc 832681 caatattgcc tgcgattgtc acggcgggtc ttttaatggg gatcaataac attttaacgg 832741 cggaaggcat tttcttcagc acaaaatcga ttgtgcaggt ttatccgcag tgggcggatc 832801 ttgctaatat gattaacctg attgcaggca cggcctttac gtttttgcct gcgttaatcg 832861 gatggtctgc cgtcaagcgg ttcggcggca atccgcttct cggcattgtg ctcggggtta 832921 tgctcgtgca tcctgatttg ctgaatgcgt ggggatatgg cgcggcagaa caaagcggag 832981 agatcccggt atggaatcta ttcggcctag aggtgcagaa agtcggctat cagggccagg 833041 tgctcccaat tttgcttgct tcttatatgc tggcgaagat tgaggtattt ttaacaaaac 833101 gcacacctga gggcatacag ctgctcgttg tcgcaccaat tacgcttctc ttaacaggat 833161 ttgcctcttt tatcattatc ggcccgatta catttgcgat cggtaatgta ctgacttcag 833221 ggcttatctc ggtgtttggt tcttttgccg cactgggcgg tctgttatat ggcggtttct 833281 actcagcgct cgtgattacc ggtatgcatc acacgtttct tgcagtcgac ctgcagctca 833341 tcggttcaaa gctcggcggc acctttttat ggccgatgct ggcgctttct aatatcgcac 833401 aaggttcggc ggctctggcc atgatgttta tcgtgaagga tgagaaacaa aaaggcctct 833461 ccctcacatc agggatttct gcttatcttg gcattacaga gcctgccatc tttggggtga 833521 atctgcgata cagattcccg tttatcattg caatggtcag ctctggcctg gccggaatgt 833581 atatttcttc tcaaggtgtg ctggcaagct ccgtcggtgt cggcggcgtg ccggggattt 833641 tctcaatcat gagccagtac tggggcgcgt ttgcaatcgg gatggctatt gtattgatcg 833701 tgccgtttgc cggaacatac gcgtatgcga gattcaaaca taaataacaa gtggggagcg 833761 ggacgtgttg aacgttccct tttcccgttt tcaatttaaa tatggtggtg gaaacagatg 833821 aaaacagaac aaacgccatg gtggaaaaaa gctgtggttt atcaaattta tccgaaaagc 833881 tttaacgata cgacaggaaa tggtgttggc gatctgaacg gcattattga aaagctggat 833941 tacttaaaaa cgctacaggt ggatgtgctt tggctgacgc cgatttatga ttctccccag 834001 catgataatg ggtacgatat tcgtgattat tactcgattt atcctgaata cggaacgatg 834061 gaggattttg agcggctagt gtccgaagca cataaaagag acctgaaagt cgtcatggat 834121 cttgttgtca atcatacgtc aacagagcac aaatggtttc gcgaggcgat ctcttcaata 834181 gacagcccgt accgtgattt ttatatatgg aaaaaaccgc aggaaaacgg ttctgttccg 834241 acgaactggg aatcgaaatt cggcggctcg gcatgggagc ttgacgaagc atcgggccaa 834301 tactatttgc atctgtttga tgtgacgcag gctgatttga attgggaaaa tgaagaggtc 834361 agaaagcatg tctatgacat gatgcatttt tggtttgaaa agggaataga cggctttagg 834421 cttgatgtca tcaacctgat ttctaaagat cagcgctttc cgaatgcgga ggaaggcgac 834481 ggccgctctt tttacactga cgggccgcgg gtgcacgaat ttctgcatga aatgaacgaa 834541 aaggtgtttt cacattacga cagcatgacg gtcggtgaga tgtcttcaac aaccgtagac 834601 cactgcatcc ggtatacgaa tcctgacaat aaagaacttg atatgacatt cagcttccat 834661 catctcaagg ttgactatcc taacggcgaa aaatgggcct tggcgccgtt tgattttttg 834721 aagctgaagg agatcctatc tgactggcaa acggggatgc acgcaggagg gggatggaac 834781 gctctgttct ggtgcaatca tgatcagccg cgcgtcgtat caagatatgg agatgatggc 834841 gcatataggg tgaaatcggc gaaaatgctt gctacggcca ttcatatgat gcagggcacg 834901 ccttatattt atcagggcga ggagctgggg atgacgaatc cgaagttcac tgacataagc 834961 tcctatcggg atgtcgaatc gctgaacatg tatcacgcct ttaaggaaaa aggaatggct 835021 gatcaagata ttacagccat tttacaggcg aaatcccgtg acaattccag aacccccgtt 835081 cagtgggatg ctacggaaaa tggtggtttt acaacgggca caccatggat accggttgca 835141 ggaaattacc gggaaatcaa tgctgaagcg gcgctgaggg atcagaattc ggtgttttac 835201 cattatcaaa aattgattca gattcgcaaa atgtatgaca ttgtgacaga gggtacgtat 835261 gagataattg caaaggatga cccgaacatt tttgcgtatc tcagacacgg cagcaatgaa 835321 aagctgctcg tgatcaataa tttttacggg acagaggcgg cctttacact gccggactct 835381 ttagcgcctg acgaatggaa ggcagaggtg ctgttgacga acgatgaagc aagggaaggg 835441 cttcagaaca tgacgcttcg cccatatgag tccattgttt atcgtttaac gaaaccgtgt 835501 taaactaagc tgggtggtcc ataatgaagg tgaataaatt catcacaatt tataaagaca 835561 tcgcacagca aattgaaggc ggccgatgga aagcggagga gattcttccg tctgaacatg 835621 agttgaccgc acagtacggt acatcaagag aaacggtccg aaaggcgctt catatgctcg 835681 cgcaaaacgg ttatatccag aaaatcaggg gaaaaggctc cgtcgtgctc aatcgtgaaa 835741 aaatgcagtt tcccgtttcg ggccttgtca gcttcaagga gctcgcgcaa acgcttggca 835801 aagaaacgaa aacaactgta cacaaattcg ggctggagcc tccgtcagag ctgatccaaa 835861 aacagctccg ggccaatctg gatgacgaca tctgggaagt catcaggtct agaaagattg 835921 acggggaaca tgtgattttg gacaaggatt actttttcag aaagcatgtc cctcacctga 835981 cgaaagaaat ttgtgaaaac tccatatatg aatatataga aggagagctc ggtctttcga 836041 tcagttacgc ccaaaaagaa attgtagccg agccgtgtac ggacgaggac agagagctgc 836101 tcgatttacg cggctatgac catatggtcg tggtgagaaa ctacgtcttt ttggaggata 836161 ccagtttgtt tcaatatacg gaaagcagac accgtctcga caaattccga tttgttgatt 836221 ttgcgcggcg ggggaaatga gagaggcgcc tgcctgcggc agcgcgcttt tttgtttggt 836281 atcaaaattg atactatcca acaaaaatgt gcgtactttt actttttatc ataatggcta 836341 caatagagat gagagtaatc taaaggagag gtgttttaca tggcagatct aaagacacaa 836401 attctggatg catacaattt caggcatgcg actaaggaat ttgacccgaa taaaaaagtg 836461 tcagacagcg attttgaatt tattttagaa acaggaagac tgtctccgag ctcactcggc 836521 cttgagcctt ggaaatttgt cgtcgtccaa aatccggaat tccgcgagaa gcttcgtgaa 836581 tacacatggg gcgcgcaaaa gcagctgccg accgcaagcc atttcgtcct gattcttgcg 836641 cgtacagcga aggatatcaa atataatgcg gactacatca aacgtcattt aaaagaagta 836701 aaacaaatgc ctcaagacgt gtacgaaggc tatttaagca aaacagaaga attccagaaa 836761 aacgatttgc atttgcttga aagtgacaga acattgtttg actgggcatc aaaacaaacc 836821 tatatcgcgc ttggcaacat gatgactgcc gctgcgcaaa tcggtgttga ttcctgcccg 836881 atcgaaggct tccagtacga tcacattcac cgtattcttg aagaagaagg ccttctggaa 836941 aacggaagct tcgatatttc tgtgatggtg gcattcggct accgagtgag agaccctcgt 837001 ccgaaaacaa gatctgctgt tgaagatgtt gtgaagtggg tttaaaagaa gaaagctgct 837061 cgcatagcga gcagctcttt tttatgcctg attcgctcta ttctgttttc tcctctgatg 837121 taagtacatt gccgttccga gtgcgctgat cagaaatccg gccaacagga tcgagtacat 837181 ggatgtggct gtgtccggaa gcaggccgcc agccggaccg tctgttcctg atccgcccga 837241 accgtttcca ccagagccgt tagtcggttg agtgccggga ggcgtatcat ttcctccgtt 837301 tccgtcagtt ggctgttttc cgcctggttt gtcggagcct ccgccatgat tgccgtcatc 837361 accgcctgtc ggttgatctg acgggaatgc cggcggtttg ttgtttgaac cggaatttaa 837421 gatcgtgtat tcgctgaagt ggtttgtata tcctgtcacc atatcatcat cgactgatcc 837481 gtgacctgtc tttgtgaaag ctttcttttt tctatcgacg tgataaatgg cagggttatg 837541 ggcttcttca atatcaaaca tgcgaagcga aagctgtacg ggctccttga atgattttat 837601 ttcttttcct ttttgcttca ctgtaaagtc atatacatct gacagtgaca catccaattc 837661 tcccgtagac ttgattccga ttgcagtgtc tgcggtttta aggttcgcca ttggcatctt 837721 catgctgtac cagtagttga acatcgtcaa tgaaggatct gactctcttt ctttcaaaag 837781 tttgacctga tcttttttca ctttaagatt gataggcttc tcttgagatc cttcatgtat 837841 tccataatag acaaatggcg tgttggcatt tttagcataa atcgcaaatt tgtcttcatc 837901 aagtgtccag ctgccgtcct tctgctttgt cggcaggaat acttctttga ttcgtccttc 837961 aactttagga gagaccttgt ttcctagttt tttcagctgt tcggtgaaaa tctcataatc 838021 aacgtagcca aggtcttcac catgggaggc ttctgtaaag acagaatatc cgtctcctcc 838081 ggcaccgaca aaattatttg ttgccacgcg gtaggtatca tccgtattta tagcaacttt 838141 gtctccgtta ggcgattcaa ttttcacttc taacacacgg tgtccaggtt tgttgtttaa 838201 tgtaaaggta tattcgattc cggccacctg agggaaagcg ccgccgccat tttccacatt 838261 gcttaggcct tgttcaaggg cttctttaat ttgttttccg gttaaatcgg ccacgtaaag 838321 cgtattgccg aacggcatca cgttgagcac ctcgccgagt gtgatatcac ctttgtcaat 838381 gcctgctctg atgccgccgc catttgttat cgctattctg gcgccggctg cttctttcgc 838441 ttttgccagc ataccgtccg cgatgaagtt tccgagattc gtttctttcg tgcgcacatg 838501 ctcacgctgg ccgtcaagcg ccacatccgt gtagccgact ttttcatttt tcacgtcctc 838561 taattcattt ttgaactgat cgagctcttg ttttgcttct gggttttctt ctgtatgttc 838621 atcaattggc agcacgctca gatttgattt atctgtttgc acaacgcctt tttcatcaaa 838681 cgcgacatca acgcgcccca agaattggcc gtattctttt gcctgcgcca cgatcgtcgg 838741 ttcttcgttg ttcacgacct ccattttgtc tacgagggtg tgagtgtgtc cgccgatgat 838801 caaatcaatg ccttttactt ttttggctag ctcaagatcc cggttatgtc cgatgtgggt 838861 taaagcaata attttattta ccttttcttc ttcttgaatc gctttgacgg tgttttgtgc 838921 tgtttcaaag gcatcattga atacgatgct tttgcccggg cttgatgtgg tggctgtatc 838981 ttctgttgtc aggccgaata cggcgacttt ctccccgtca acgtctaaca gaatgtaagg 839041 gtgaatgccg gcctctttct tttcacctgc cgtaaaggtt tgcggctttt tgacaaatga 839101 tttcagcttg ggctcatttg acacatctac gtttgcactg acaatcggaa attccggcgc 839161 ttcaaagtga tagcggttcg ccggatcaac ggttgcgctg tttccgctta gaaaatcaga 839221 aagcaccgtc gggcctttgt caaattcatg gtttccgaag gtcatggcgt catagcccat 839281 catgttcatc attttcagat cggccaaacc gttccattta gtaaaataca gatcgccgga 839341 aaacacatct cccgcatcaa ggagaatatt gtgatttgtt tcgctgcgta cttcgttgat 839401 tttcgtcatt cgtctcgctg catcatcgag atgggcgtgc gtatcattgg tgtgcatgac 839461 ggtcagatcc cacagtccgt ctttaggagg atctggattt gaatcatcat cgaattgcag 839521 cttatacaca ccatagcctt cattcgcaga cttgcctaca taagcgacat cgtctgcttt 839581 atcggcaaat ggcttggcca aaagcgagga ttcaaacgtc agattcgtgc cggaaacagg 839641 cgcgattgac cagttgttgt ctgcttttgg attgactgtt ttttgttcaa taatgtaatc 839701 catcagcacc tgcctatttt caactgcaga gccgtggaca attttatcgc tcgtcagatg 839761 agggaacccg ccgcctccgg acgcacgata gttattggtg actacgagaa attcctggct 839821 tgggctgatc ggcttgcctt cataggaaag attgatgata cgggatgaat ccgcattgat 839881 cacttttccg ttctcattgt atttagccgg ttttgtcaca tcgacctgat atgtgacacc 839941 gtcaatcacg tcaaaattat aggagcggaa attctcgttc agcaaggcct ggtcgccgcc 840001 tttagctgga tcaatttgat tgaattggcc tgctgacatc tccagccagt ccttgacctc 840061 gctgcctgtc agcttgacga tttgaacagt attatcgtaa agatacaagt caccgacatt 840121 tttaatcgca agatctccgg ctggaatgtt tgtatagtaa ttggctccgt ttctgccgcc 840181 tgctttaaac ggcgctccag cggataaaat cggcaggttc ttgtactcgg tatccttcat 840241 ttctttttca gcgtaccact tttgcgcgtc agtcacgatc tgaatggaag gatcatcttt 840301 gacctgtgca aagaagctgt taatatctgc ttcggttttg ccgactggct ttcggacata 840361 ctccagtgtg ttttggtgtg tttgctgaat ggtgtttgta acggtttcgt ttcttgatgt 840421 gacgttgcca gcaatagatt caatacttcc tttggaatct gctaccttcc atgagccgtc 840481 cgccttttca agcttgaggt caatcacgcc taaatatttg ccccagctgc ttggcatgac 840541 gacaggaatg ccgttaattg ttcccttttc cacattgaac tgagcaacac ccgcatactc 840601 ggcggaagga aagagtccgt gctgatggcc cgagataatc gcgtcaatgc ctttcgtttt 840661 ggtggcaagg tcaaacacgg cgttttctgc gcctgatgat tgcgcctgct tttcaatgcc 840721 ggtgtgggcg agggcaataa tgacatctgc gccttccgcc ttcattttcg ggatcgtttc 840781 attggcggat tctacgatat cctgcacctg aacttgcccc tcgagattct ttttgtccca 840841 tgtcatgatt tgcggcggga caaagcctat gtagccgact tttactttct gctcattacc 840901 gttttcatca atgagggttt tttcattaat cacatacggc gtataacggt tttcgccgct 840961 agttgttttg acgttggcat ttacaatcgg gaaatcggct cctttgattg tgccgtcgag 841021 aaagtcgagc ccgtagttga attcatgatt gccaagcgtt ccggcgtcgt atttcagcgc 841081 attcatgacg ctgataatcg gatgggtttt cgtgccggag ataatgtcgt ctttttgata 841141 tttcaccgcg tattcaccca gcggattccc ttgaatcaag tcgccgttat ccacaagcag 841201 ggtgttaggg ttttgctcgc ggtgcttttg gatcaattgc gctgttctcg ccagaccgaa 841261 atccgccgtt tctttgtcgc tgtagtaatc gtaatccatc atgttggcat gaatatcagt 841321 cgtagccaaa atactcagat gcacctgagg agccgcgctt tcttctgcat gaatgggtgg 841381 tgttgggagg attaggctaa gtatcataat tgggggcaaa agaatacgga gaatgttttc 841441 gacgtgtgtt cgtcttttct gtattctcac cagttctcca cctttcaacg aaatttgtgt 841501 tacagctcct attgtaagaa tattttgtaa ctatttgtag gtgtttcttt atgattattg 841561 taaaagggag aaaaatgagt attatgtagc agtatcaaac gacaaatact gggcatttat 841621 gcttatcgtt tgtcacaatc gcggaatgtt tattttagtg tggctggggt agagtgtttt 841681 atgtagacat ataaagcggg aggttatgaa tcatggggaa aaaaattgca gttgttttaa 841741 catattattt tgaggacagc gagtacactg agcctgcgaa agcctttaaa gaagcgggac 841801 atgaactgac tgtcatcgaa aaagaaaaag gaaaaacagt aaaaggcaag cagggaacag 841861 cggaagtgac ggttgacgcg tccattgacg acgtaaattc ttcagacttt gatgcgcttt 841921 tgattcctgg aggattttca ccagaccagc ttcgcgctga cgatcgtttc gtccaattta 841981 caaaagcgtt tatgactgac aaaaagccgg tatttgccat ttgccacggc ccgcagcttt 842041 taatcaatgc gaaagcgctc gacggccgaa aagcgacggg ctatacgtcc attcgtgttg 842101 acatggaaaa cgccggtgcc gacgttgtgg acaaggaagt ggttgtttgc caggatcaat 842161 tggtcactag ccgcacaccg gacgatatac cggcatttaa ccgcgagtca ttggcattgc 842221 ttgagaaata agaaaaaacg gacgctcttg ggcgtccgtt tttttgttgc ttaggcttga 842281 gcacctgtca gtttcttgta cctgtaatac aagaaagcag ctgcagccgt tccgatgacc 842341 gcaatgccga agtcgaatat gaaaatatgg gcgatgcccc ccgcttttgc gataagccct 842401 gttgcaatcg gcagcagaat cgatgcaaga cttgaagcag tcgctacaat tccggtaacg 842461 gttccttttc gcttccagaa aagctctgtc attaacgtaa tggtaatttg aaacacaccc 842521 gcagttgaaa agcctaagaa aaaggcagtg atgtccagca caactgggat atgaacggtc 842581 agcatgactg cgagcgtaca taaagtaata ataggatata agagcgttat gaagacaggt 842641 ttgacccatc tattcagcaa aacggctaat aataaaacag atgccagaga tcctatacta 842701 taatagctca gcaattgtac agatgctgat tcagctaaac cggctgcctt ttgcgcgtag 842761 ctcgggagcc agatttgaga aaccgtaaat aaagccgtgg atgtaaaacc gatgataatc 842821 agtgcggtgc cttccttctg aaaaacgggt tcagacaaga aaacgggaga ttcctgttgg 842881 ccgctattag ttggtttctt atgtttttta ggaaacgaaa gcgttgataa ataaataata 842941 ttcaggagat agaccgctgc cggcagataa aaagcaaatc cgtaaaacat gctgtggtct 843001 gctaaaaatg tgatcaaaag cggcaaaagt gcggccccca cagacataaa ggctttaacc 843061 aagacatttg ccgaaccgga agcagacgga aagagctcgg ttagggccgg atatgttccg 843121 gcatccatgg ctgaattagc gactccggct aataaagcga acacaaacgc cagctcatag 843181 ctcggtgata aaggaatacc gactaaaaag acggccataa ttcccgcaga agcgacaaca 843241 agcggctttc tgccgatttt atctgataga acgccggaaa tgccgtatgt cagcagtttg 843301 ccaaacccga tagcggcaat gacataactg atgccggtcg gatcggtatt ccactgtttt 843361 gttaatgaag acatattgga tgcgagaatg atgttgacca tccccagaaa gaagtagttg 843421 atatacattc cggatgctgt tttgatagat gtcgtttgca tgcttgtact ccttcaaatc 843481 ttattcgaac actttgctgt tttggtttgg ggaaatgata aaaaagactc gccgagtttc 843541 cggccagtct ccattattta cgaagcgagg ctaattcttg agcaatcgcc tgcatttcac 843601 ttgggctgaa tgattctttt ttcatcacca ttctgtgaag gtacgtgagg tcttcaatct 843661 tctcatcact gaaatcctcc gctttgatta cgccgacgtt cagcatgttc agcttttggg 843721 aaatctcttc aatcatttga gttaatgttt ctgtatttgg gctggacaaa gggttccatc 843781 ctttctatgc gcaatatagg tatgttttat tctaacagaa ttccatcaga aaaaaaccct 843841 attctaaaag caggctgttc attccaaaaa agtgaagaca tcagttgaaa agaaaatgaa 843901 catcctacta agatattcat gaaggtttct ttttagagaa ataggggcaa agaataggga 843961 ggttgcacat catgataagc gtgttatttg tttgtttagg taacatttgc cggtctccga 844021 tggcggaagc gatttttagg gacctggcag ccaaaaaagg attagagggg aaaatcaagg 844081 cggactcagc cggtattggc ggctggcaca tcggcaaccc cccgcatgag ggaacgcagg 844141 agatattgcg cagagaagga atcagctttg atggcatgct ggcgcgtcaa gtcagcgaac 844201 aggatctgga cgattttgat tacatcattg caatggatgc agaaaatatc ggaagtctca 844261 gaagcatggc gggttttaaa aacacctcgc atatcaaaag gctcttggac tatgttgaag 844321 attcagatct ggctgacgta cccgatcctt actacacagg gaactttgaa gaggtctgcc 844381 aattaatcaa aacgggctgt gagcagttgc ttgcatccat tcaaaaagaa aaacaattgt 844441 gagtgaaagg agaatttgca tgaacaacga acgtttaatg ctgaaaggga tatttctcgg 844501 agctgcggca ggcgcggcgt tatcactgct ccataagccg acaagacagg cgtgcgggat 844561 gagatggctg acatgcaagc ataaactttc actgtacaaa agcaacccag agctgttaaa 844621 aaacactgtc atcacaaaag tggatgaggc caaaaagctc gcccgaacgc tttcaaagga 844681 agtcgacttt gtgaaccagc aggtgaaaga gctgaagaaa acaacgccgc aagtgatgga 844741 actcgtgcaa gaaacgaaag agcatttttc aaaaaaatga tcaaacatgc gaggtgagac 844801 gacatgagtt ttttgaaaga gcttttcagc agatacaccc ttcatgaagg acaaagtaaa 844861 tcagcggagc tggcgtattt ttttctattg tcactgtttc cgtttttgat ttttatgctg 844921 acgctcaccg cgtatcttcc gctttctacc gatgatgttt taggagtcat agaacaatat 844981 gctcccgcca gtgcgatgtc actcgttgaa tccattaccc atcaaacctt aaataatcga 845041 aatggcggtt tgctgtcatt cgggattatc gccgcattat ggtctgcgtc taatggaatg 845101 aatgcgatcg tccggtcgct gaaccacgcg tatgatgtgg aagaaaaccg ctcttttatc 845161 attgttcgtc taacctcgat ttttttgacg attgccatgg tatttacgat tttagtggct 845221 ttgcttctgc cggtatttgg ccgggagatt ggaaggctcg cttctgactt tgtcggcgcg 845281 tcggatctgt ttttatccgt ctgggccgcc attcgctggg gtgtcagccc gcttgtgctt 845341 ttgattgttt tttccgcgct gtatgtgatt gcgccgaaca aaaagctgtc tctccggttt 845401 gtcatgccgg gtgcggtctt tgcgactatc ggctggatca ttgtcagcac attgttttca 845461 ttttacgtca gcacgtttgc gaactatagc gccacttacg ggagcatcgg gggaatcatc 845521 gttctgatga tttggtttta cttgagcggc attttaatta tcctaggcgg agaaatcaac 845581 gctcttttac ataaacgtaa aaagcttcct gatgaaaatc cctaccatta gcgcacccta 845641 taaacgaact tcggttcaaa aagaagtcgg ggggatatcg tgatgaccaa gcatacgaaa 845701 aaaggcggaa gccataacaa acaaaactcg aaaagcaaat cgagccataa aacaagcgga 845761 agcgccaacg gacaaaacgg ctaccattag cataaaagcc tcctgacatg atgtcgggag 845821 gctttttgat taagaagatg aagaataggt ttcagccggt gaccagcttt tcggtttgcc 845881 cagcacaagg gccagccaca cagagctaag cgtgagagta atgaagtaga acaagtttgc 845941 gctttcaaat gtctgcatat accagccgcc ggcaactggg ccgaggatgc taccgagact 846001 gaatgtaatg ccgcaaagca ggtttcccgc cggcaggagg tgaggcggaa gaaggtctgt 846061 catatagctg atgccaagtg taaaggttga tccgactgcc attcctgcaa taaaaaagca 846121 gccgccgatc acgtagggcg aaggaaatac accggcgatg aaaaagcaaa gagccccagt 846181 cagtaaaatc accagcagca cattccgcct gccgtattta tcgctgagga tgccgagcgg 846241 aaactgaaag ataatgcttc caatcgcaaa tgcgggaagg atgatcgcta ctgcgtctac 846301 tgatatcccc aaacggagcg cgtacaccgg aaagcttccg ttcagcgccg tttccagaaa 846361 gccatagcca aatgtaggca taaaggcaac ccacccaaac agcatggcct gataaaatcg 846421 cctgaaacta ttgtctgatt tggtttcatg aggactggtt tccgggtatg cattttgtag 846481 aaagaaaaca aaaagccacg caaacagact gatgcagccg gacacgataa aaggaagcga 846541 cggactcagc ttgacaagcg gcaccatgaa cgggcctgcg gcaaagccaa ggccaaagga 846601 aagcccataa atagacaggt ttcttccgcg attttgtttt gatgacatgg aggtcaccca 846661 cgtttgcgta gaaaagtgaa gcatgtggtc gccgattcca atgaacaggc gaagcaggaa 846721 ccagacccaa actgactgaa gccaaataaa tccgaataag cttaaaatga caatgcttcc 846781 gcccatgacg atcagcggct tgaacccgag ctttctgagc ggtgcttcca taaacggcga 846841 agccaaaagc acaccgatat acagcccggt cgcgtgcagg ccgttgatag cagcggattc 846901 tccatttgtt tcaaaaatga ttgaaatgac aggcagcagc atgccttgtg aaaacccgga 846961 aatggaaacg agcaagacaa ggataaagaa atgaaatcgt gacatcgtgt cagttctcct 847021 tatatggaat ctatgttgat cgtacaacgt tttccaaaag caggcaacct gaaaaaagcc 847081 tatatcacgc tatacatttg ccctcgtgta atcatgaagg tttttgtgaa gaataaaaat 847141 aaaacaagtc ataaaaaagg agctatttca ccatgaatcg tatctttttt attttagtgg 847201 cggccggtgt tccgctttct gtgattggca gtttgatgca ttggccttcc gcggttctat 847261 ttgcagttta ttgcgtgacg attatcgcgc ttgcaagcta tatggggagg gcgacagaat 847321 cactgtccat cattgcagga ccgcgtatcg gcggtttgtt gaatgcaacc ttcgggaatg 847381 cggtggagct gattatttcc ctttttgcat taaaagaagg cctgacagga atcgtgcttg 847441 cctctttaac cggttcagtg ctggggaacc tgttgctggt agcgggccta tcgttttttg 847501 tcggcggttt aaaatataag cggcaggaat ttaatatcca tgatgcccgc cataactccg 847561 ggcttctgat ttttgccatc attgtcgcct ttgtgattcc ggaggtattc tctgttggta 847621 tgggaaacgc cagcaagctc aatttaagca tcggcatcag catcattatg attctgttat 847681 atgtggcggc gctgtacttt aaacttgtca cgcatcgggg cgtttatcag ccgaataatg 847741 ccgctcagac tgaagaagag gaagagccag aatggtcagg gaaggttgcg acgattgtct 847801 tgtttgcggc aacgattgtg gttgcataca tatccgaaaa cctggtccat acctttcact 847861 cggtggctga acagttcggg tggagcgagc tgtttattgg ggtcatcatc gtggcgattg 847921 taggaaatgc ggcggagcat gcgtcagcga ttattatggc cttcaaaaat aaaatggaca 847981 ttgctgttga aattgcagta ggctctacgc tgcagatcgc tatgtttgtc gcaccggttc 848041 tcgtcatctg ttctatcttt tttccgacaa gcatgccgct tgtatttaca ttgcctgagc 848101 tcgtcgcgat ggtatcagcg gttctcttga tgatcgcgat ttcgaatgac ggggattcca 848161 actggtttga aggggcgaca ctgcttgctg catatgtcat tatggcgatc ggctttttcc 848221 ttctttaacc tgaaaaaatg atggataaca acaaagcggg atgaaaagac taagggaaaa 848281 tgccatagaa agagtgatat gatgaaaaag ctatttcatt ccacacttat tgtgttgtta 848341 ttctttagtt ttttcggcgt tcagcccatc cacgcgaaaa agcagtttaa ggttcctaat 848401 tctgtcgcaa gcatttcaaa ggaaaacacg tatccgaatg cttcacagga tcagccaatg 848461 cttcagccga gcaagctggc aaaggaattg ctcgatcatt ctgaggtaaa gattgaaaat 848521 ccgcatctca tcaaaatgct gaatgaatcc aacatatccg gcacaccgct tgcagtaggg 848581 taccgggcga caatatttct cgggaaatgg gcgctcggct atgaatcaaa tgaaacagtc 848641 gcaaactggg aatataaaaa aatcaataca aaccgtgcgg ataaccgcgg cgggaaagaa 848701 acggctgaaa tgcattatgc ccaggaacag cagtacagag tgaagggcgg cttgacagct 848761 aaagttccaa atgctgaaga tgtcaaaagc atgatgatgc aaaaagcaat gaagaaaacg 848821 aacctcccgc ttgcatttga gacggtcatc ggggctggca caaaacggga tcagatttat 848881 aaagtcgctc ctaaaaaaat cggttatcta catgcatatg caccggctgt gaatgaaaaa 848941 ggaaaagtga cttacggaga agtgtactta gtgctgaaag gaaataaacg aaaactcgtc 849001 gtgaaaaatg tcacgtcaca gggaatcggc gcgtggattc cggttcaaga tcatgtcacg 849061 tttggctttc agctttcctc actgccaaga taaataaaaa actgattcca actcggaatc 849121 agtttttttg tttattgggt tctctcgatt cggaccgctt cctcaagcat ttgcacattg 849181 ttttggtaga gctggcgaac gagaacccgt cttactgcaa ggctggcact gaaataatca 849241 tcatctttca ccatgccttt aaccgtaaat tcgacgccgc gattgatttt attcaatgcg 849301 gtgatgccgt ggatttgaaa cggttctgtc ggattgccga attcatcccg cttcaatgaa 849361 tcacgaagct cttcattcag catgtcacat gcctcttcca acacgctgta cacgcggtcc 849421 ggatcttctt taaagctgat aagaaaggat tcggtaatcc gcataaaatc aatattatag 849481 ttctctattt gtctgacctc gccgttgctg atggtgagca gcttcccgct ccattcccgg 849541 atttgcagcg agcggaggcc gatttcctcc actgtcccgt tgaacaagtt gttgacggtg 849601 acataatcgc ctttgtgcag ctggcgttca tatattaaga atacaccagc cagcacatct 849661 ttgatcagcg attgggcgcc aaaaccgatc acgatacctg ctacgcccgc cccggccaat 849721 atcttgccga aatcatgcac aaataaagaa ataacgtaaa agataaaacc aattgttgcc 849781 gtatactggg tgacagaacg gacaaggctt tcaatcgttt tttccttttt ttcttcaata 849841 aagtccgtcc gtttaaaaaa tagctgtacc agccggttga tgataaagac accgatccaa 849901 aggataacgg caacgaggag aatatcgacg attttatttt gaaaaatctc cgtaagtgtt 849961 tctttcatcc gcatctaact cctggcttga cgttttgtga agtctgtatc ctgataataa 850021 ctgtttttga caagaacatt cggtccgagg caccggacat tcgggcagtg gcaactcagt 850081 tctttcgcaa gcttggtctc tctccacttt tcataggcgg aagggaggct gtccgtctga 850141 atgttgccaa gcggcggggt atcaccgaaa tcggtcacga taatgtttcc gtcgaaaatg 850201 ttcacattca ggcgggatcg gccgtcaggg tcatttcgca ctgtgacgtt tttcgccgcg 850261 cgaagccggc gaagcagctt ttggtcgtct tcgtccggac tgcaggcata aaacggcagc 850321 gttccgaaca gcatccacgt attttcatca cgaatatcca gcaagcggtg aatggcctgt 850381 ctcatctctt tcaggctgag ggattcaaga gcgcttgcga aatcgcttgg atacattggg 850441 tggacctcgt gacgctgaca tttcatatct tctgtgattt ggcggtgaat atgctcaata 850501 tgcggaagtg ttcgtttgtt cagcatcgtt tccgcagata ccattactcc ggcatccacg 850561 agcgtgcggc tgttttcgat cattttttca aaatagcgcg cgcgctgttc gaaggtcggt 850621 tttctgtcca tcatggcaaa gccgatttca gcaaaatctt caactgttcc ccagttatgt 850681 gaaatatgta gcacatcgag atacggaatg atccattcgt accgctcgat gtcgagggtc 850741 agatttgaat taatttgtgt ccgcacaccc cgttcatggg catatttcaa taaaggaaca 850801 acatattctt ttactgattt caacgaaagc atcggctctc cgcctgtgat gctgatggat 850861 ctgaggcgcg ggatttcctc cagccgtttt aacagaagat ctattggcag agcattcggg 850921 tctttaggct gcaatgtata gcctacagca caatgctcgc atctcatatt gcacagtgtc 850981 gttgttgtga attcaacgtt tgtcagctgc atgtctccgt attggtcaac atccatatag 851041 gcttcccaag ggtcaaactc gggcgtaatc ggacgcagct tcgtgttttg tgtcatgact 851101 atctaactcc tttataaatg ggcatactaa cgctgccaac agttaatttt agacctgatt 851161 tgccaagatc gcaagtagcg cggcgattga aaaacggcaa aaaatgagct accataataa 851221 aaaatgaatg gaggaacaga atggggaacg ccgtaaacaa taaagatcag cagattgatt 851281 atttaaagaa cagacttgac atgtttatga acgtcatcga ttcattagac cctgaagcaa 851341 ccgacgttga agatatagac aggcttatca gcatgcttga tgacctggaa gccaaatacg 851401 aacgttttaa aaaagattgg gaataaaacc gcgtgcccgc cgcggttttt ttattggcat 851461 aaagcaacag tataaaacaa agtctctatc tgtaaaataa gaaaaaatgc agaaggagcg 851521 ctggccatga agtggatgtg ttcaatatgc tgcgccgccg tattgcttgc cggaggtgca 851581 gcacaggcgg aagcggtgcc gaatgagccg attaattggg gctttaaacg aagtgtcaat 851641 catcagccgc cagatgccgg gaagcagctg aacagtttaa ttgaaaaata tgacgcgttt 851701 tatttaggga atacaaagga aaaaacgatt tacttaacgt ttgataacgg atatgaaaat 851761 ggctatacgc caaaagtgct tgatgtctta aaaaaacatc gcgtaacagg aacgtttttt 851821 gtcaccgggc atttcgtaaa ggaccagcct cagctgatca aacgaatgtc agatgagggc 851881 catattatcg gcaatcattc ctttcaccat ccggatttaa cgacaaaaac agctgatcag 851941 attcaggatg aacttgattc agtcaacgaa gaggtttata aaattacggg aaagcaggac 852001 aacctgtatt tgcgtccgcc gcgcggcgtg ttcagtgagt acgtactgaa agaaacgaaa 852061 cgcctcggct atcaaaccgt tttctggtcg gtcgcttttg ttgattggaa aatcaacaac 852121 caaaagggaa agaaatatgc ctacgatcat atgatcaagc aggcgcaccc gggagccatt 852181 tacctgcttc acaccgtatc gagggacaat gcagaagcgc tggatgacgc gattacagat 852241 ctgaaaaaac agggctacac ttttaaaagc attgatgatc tgatgtttga gaaagaaatg 852301 aggctgccgt ctttgtaaaa gagaaagacc tctccttaaa cggagaggct tttctttatt 852361 ttatacattt aatcagtgcg gcccagtcca gatccccgaa gcctttctca atcccgcttt 852421 caaaatggct cttggccagc tcggcaagag gaagatttgc agaaacccgt tttgcggcgg 852481 cgagtgccag gttggtatcc ttcagcccta aagacatttt gaagccggcc ggctcaaatt 852541 tctgctcggc cataatggtt ccgtaatttt gatagactgg agaaccaaag agcgcgctgg 852601 cgatttctaa aaattgtttt tgttctaagc cgtatttctc catcattaaa aaggattcag 852661 ataacgcctc cagcatggac acaagcaaga aattaatgct gattttggct gcatttgccg 852721 tcttgctttc ttcgccgacg tcaaatatct gctggctcag gctgtcgagc agaggcttgg 852781 cagcttgctt tgcttccgcc ggtccggctg ttatgatacg gagcgcggct ttggctgcgg 852841 catccggtct gccaaggaca ggagcggcga gaaaaaattg tcctttctct gcatgagccg 852901 ctgcgagctt ttctgagaac tcaacactga ttgtgctcat cgagatgtgt atgccgttct 852961 ctgctaatcc ttcaagcagc ccgtcttctc cgaatgtcac ggtgctgaca gaatcatcat 853021 ctgcaagcat tgtgatgaca atatcagcgg actttgccgc cagccgcggc gtatcagctg 853081 cctgtgcgcc ttctgtgaca aggtcttctg tcttttgttt cgtccggtta tagacagtca 853141 attcgtagcc tgcttgaaga acatttcggg caatgggctg tcccatattg ccgagtccga 853201 tgacagcaat tttcaatcta atcactccct gaatattttt tccattataa acaatatgaa 853261 cagaatatgc atagcgatcg gcttacaaca aaaaagaaca gctgctcgct gtcctcattt 853321 aaaaatattg aaccatcctt tatgtacaaa ccaaatcagc attccaatca caagcgcggc 853381 catcaggcca agtacagcga aatatccgta tttccaatgc agctccggca taaagtcgaa 853441 gttcataccg tatacaccgg caataaaggt gagcgggatg aaaatggttg atacgatcgt 853501 cagtgtcatc ataatcgcat tcatccggtt tgagtttagc gtcacgtagc tgtcacgcaa 853561 gtcggacgtc atgtcacggt tggattccac aatttcagac aactttaaca aatgatcata 853621 tatgtcgctg aaataggctt tcgtttcccg ctgctctttc acatggtcaa ggcttaaaat 853681 ccggtagagc aaatcacgca tcgggataat cgtccgtctc aaatgcaata ggtctgttct 853741 gagatcaaac acctcgttca tcagcgttcc atacgttttg tggggacggc tttcttcaat 853801 ttcattcagc cggtcttcaa ttttatacac gagaggaaaa tattcatcaa caagctgatc 853861 catgatcata taagaaatat gcccgggccc ttttttcaat atgtccggtg aagcatacaa 853921 acgctcccgg actttagcga taccgggcgt ttcgtgtaaa tgaaaggtga cgacaaattt 853981 ttcgccttga aagatatcga cttcctccgt ctcaagtgtt tccttattca gcgcatgaat 854041 cacgtaaaaa cgatagccgt cataatggtc aagctttggc cgctgcatat gctggaagca 854101 atcctcaatg gcaagcgggt gaaaatgaaa aaaatctctc aataacgccg tttccgtatc 854161 ctccgggccg taaaaatcaa cccagtacca tgcaatatca ggctgttcca ctcgttcgat 854221 cggtatattt ttcagcagct gatgctctgt tgtgattgcg gtaatgttga tcataaacaa 854281 ccctccacct gccattatat catgcggtct ttatgagaaa agtatacggt actctctgcc 854341 taattccagc ggcatgttat actgaacaaa aacggaaaaa agggtggatc tcatgtggaa 854401 ggaaaaagta tctgtcacgc ctccgtatca ttttgaccgc gtgctggaca ggctgtcttt 854461 agaccccctc aatgctgttg atcgagaggc gagggaagtc cgtgtgccaa tcagaaatca 854521 agcgggggac gtatgtattg taaaggtaca ggcgttaggc catgcgggcg agcctgagtt 854581 cctcgtcagc ggggaaacgg atcagggaga aatgatgaag gaaatcaagc ggatttttca 854641 atgggaaaat catttgcagc acgttctgga tcatttttca aaaacgagcc tgtccgccat 854701 ttttgaagag catgccggga cgccgcttgt tctggactac agcgtgtaca actgcatgat 854761 gaaatgcatt atccaccagc agcttaatct ttccttcgct tacacgctaa cagaacggtt 854821 tgttcatgcg tttggcgagc agaaggatgg cgtgtggtgc tatccaaagc cggaaacgat 854881 tgcggaactc gattatcagg atctgcgtga tctgcaattc agcatgagaa aagcggaata 854941 caccattgat acatcaagga tgatcgcaga aggcacactc agcttgtcag agctgccgca 855001 tatggcggat gaagacatta tgaagaaact gatcaaaatc aggggtatcg gcccgtggac 855061 cgtgcaaaac gtcctcatgt tcggacttgg ccgtcccaat ttattcccgc ttgccgatat 855121 cggcctccag aatgccatca aacgccactt tcagctggac gataagccgg caaaggatgt 855181 catgctggcg atgagcaagg agtgggagcc ttatttaagc tatgcgtctt tgtatttgtg 855241 gaggagtata gaataattcg tctgacaatg aaggaaatcc tgcaaacgtg ttatactaga 855301 aagatgtgaa aaaaccattt cactttctgc catccgcaga aagcttcata tagaaacgga 855361 gagaacaacg tgaaccaaca aaagaaacag gcgcccgtcg aactgaaggt cggacaaact 855421 tttccgctga cgattaagcg tctcggcatt aacggagaag gtgttggcta ttttaagaaa 855481 aaagtcgtct tcgtgcccgg cgcgcttcct ggcgaagaag ttgttgtgca ggccacaaag 855541 gtccagccga agttttcgga gggccgcatt aagaaaatcc gcaaggcatc tgagcaccgg 855601 gtggcaccgc cttgccctgt ttatgaacaa tgcggcggct gtcagcttca gcaccttgca 855661 tacagccagc agcttcggga aaaacgtgat atcgtcattc agtctcttga acgccatacg 855721 aagtttaaag ttgaaaacat ggaaatcaaa gaaacgattg gcatggacaa cccgtggaat 855781 taccgcaata aaagccaatt ccagatcggg cgctcgcaaa gcggcagcat catcgccggc 855841 ttatacggcc ttgattctca tgatatcgtg ccgattaaag actgtatcgt tcagcatccg 855901 gcaacgaaca aaacaacagg catcgtccgc cgcattttag aggacttcaa tgtgtctgtt 855961 tataatgaaa gaaaacgaaa aggcgacgtt cgcacgatcg tgacgagagt cggctttgaa 856021 acaggcgaag tgcaggtcgt gcttgtaacc gcaaaagaaa cgcttccgca caaggaagaa 856081 atcgtcaaag cgattcaaaa gcgattgcca gaggtcaaat ccattattca gaatgtaaac 856141 ggggcgaaaa cctcagtgat ttttggtgag aaaacaaaac agctcgccgg aaaaacagtg 856201 attcaagaag tgctcggcga cgtatctttt gaattgagcg cccgcgcttt cttccagctc 856261 aatccggaac agaccgtcaa gctgtatgat gaagtgaaaa aagcggcgca gctgaccgga 856321 aaagaaaaag tcgttgatgc gtattgcggc gtcggcacta tcggcatgtg ggttgcggac 856381 ggagcgaagg aagtccgcgg catggacgtc atcaaggaat caattgacga tgctaagaaa 856441 aacgccaaaa aacacggcat ggcaaatgcc acatacgtaa caggaacagc cgagcactgg 856501 ctcccgaaat ggacgaaaga aggcttccgc ccggacgtcg tcattgtaga cccgccaaga 856561 acgggctgtg acagcacgtt cttggacacg atcaaaaaag tcaaaccgaa acgctttgtc 856621 tacgtttcct gcaatccatc cacgcttgcg aaagatttgc agacgctgtc gaaggactat 856681 cgcgtggact atattcagcc tgtcgatatg tttccgcaga cggcgcatgt tgaagcagtg 856741 gcgaggcttg tattaaaatc gtctaactaa aaagaacatt tcccagtcat aaaatagttt 856801 tcctaataag acctggattt cggtaaaata aacaattccg atttccgggt ctttttcgtg 856861 cgcagctctt gtcctaacgg tctgttctca attttatctt ccttcttttc gcggagatct 856921 ttattttaac tggcgaaaag aattgaaaaa acgtgttgaa aagcaggtga aaaaaagcgt 856981 tatttaaccg gaaaaatatc ctcccagtat gtttaaaata catgagtaga atgatgtaaa 857041 atcatagatg tattttcata atttgtaaaa ttatatattg acttgcagtt attacgtgtg 857101 aaatattgat gataggaata taaggaaagt atggcgtata tcatttcaag agtcattcga 857161 tgtaaaaagt tgaaacattg taataaatga aagaggtgaa aatgatggcc aaccccattt 857221 taaaatgcat aacgtatgag cactacaaca attaaataat agtgccgaga cgataacaac 857281 tattacagta atacctacaa tggttatatc cttgcgacaa tcatgcttca taatataatg 857341 attttagatt gacacttggc taaaaagtat tgcagagaag gaaatggata attaaatgga 857401 taaagtatat aaaagaagtt ggtttcaaac atttttggca tttttagtat ctcagcttta 857461 ttttaatttt gtagaattaa cgggatgggg tcctaagtat agagaaatga atggattccc 857521 agcaaacata gttgaactag atttctttca aacatatctt tcattctatg ataatccatg 857581 gtttaatatt attactgttt tcttgggagt tttcactatt atacaaataa ttacagggat 857641 aacaaaggat attcgaaatt aaagcaataa cttctgatgc cttatttaat gatgaaagaa 857701 aatgtacact ttcttaatta tcttatgagt gaagactgcg acacttagtc agcagtctat 857761 tttatggttc tggatcagga ttaccgaatt ataaccctat acaaatatat agtaggttgc 857821 cacttgctgc gttggttatt ttctaaatca tgagcaaatc ccaaatgatt cagattgaag 857881 ttcttgaatt cttttaaata agggtttatt ttctcttctc atcctcttta ctccatgtga 857941 ttcacaagtg gtagcagctt aagtaggttt tttcattctc ttgagtactc agttatacca 858001 cccccaactc aatttgcttt atctctatta gtttttccgc aaatatgata tagagatacg 858061 gatatggtgt agtgttaaat atcttatctt caataacagg gcaattattt tgcgttggta 858121 atatggagaa ctcatatgat attctattta ggttggaatc ctttttatcc aaaaagttca 858181 aaagcaaggc cactaagaaa gacgaaggtc agcgccagtt aaccagaata taaaaaatag 858241 ggtagataat catcccacgt gaaatcttca aaatttacta tagattgata agaaatgctt 858301 tcgcatgcga taagtgtaaa agaagcatgg tcagttttta atttgggata aaggttcagc 858361 cgtatcccat aatgaaagga tttgattttt gttatgacag aaaatttctg gcgtgaatta 858421 ccacggccgt tttttgtact ggcaccaatg gaagatgtga cagatgttgt tttccggcat 858481 gtagtaagtg aagcaggcag accggatgtg ttttttacag agttcacaaa ctcagagagc 858541 tattgccacc cggatgggaa ggatagcgtg cgcggccgtt tgacttttac agaggatgaa 858601 cagccaattg tggcccatat atggggagat aagcctgaaa acttccgtaa aatgagtatt 858661 ggcatggcag agttaggatt taaaggacta gatatcaata tgggctgccc tgtgcctaat 858721 gtggcgggga atggaaaggg aagcggcctt atttgccgtc ctgcagttgc ggcagaatta 858781 atacaagctg caaaagcagg gggattgcct gtaagcgtga agacaagact tggatacacg 858841 gatgtggatg aatggcgcga gtggctgaca cacattttga aacaggatat tgcgaatctt 858901 tctattcatc tgcgtacaag ggcagaaatg agcaaagtag atgcgcattg ggagctcatc 858961 ccagagatta agaaacttcg tgacgaggtg gcaccagata cattgctaac aataaacggg 859021 gatattcctg accgtcaaac tggcttgaaa cttgctgaac aatacggcgt cgatggaatt 859081 atgatagggc gcggtatttt tacaaatcct ttcgcttttg aaaaggagcc gaaagagcat 859141 agcagcaagg aattgcttga tctcttaagg ctgcatctgg atctccatga tgaatattca 859201 aaagaagaag cccgtccata caagcctctt cctcgctttt tcaagattta tctccgcgga 859261 ttccgagggg caagtgaatt aagaaatcaa tgcatgaaca caaagtcaac agatgaagtg 859321 cgtgcattgc tcgacgactt tgagagaaag tatcttgatg ggatagagta acagcagtgc 859381 ttgattcaaa aaaggctaac aaaataaagg gatttttaca caattcttga ctaaaataaa 859441 cctggatttt cggtaaatcc gggtcttttt tgtacgcagc ttttactcag cctgtctttt 859501 ctctaattta ttgtaagaaa ataatggtat atttagtgga gatatcatat aaagggggag 859561 aggaaaatga aacggctatg catcatcccc tgcggcaaga aaaaaatctg ggatgtccag 859621 cctgatgccg ggccggtaag agcagaggac gcttatctca gcccgtttca tcaggcgtgc 859681 gagcggtatg caaaaacatt tttcgatgag tgggtgattt tgtcggcgaa gcacgggttc 859741 ctccgccctg atgatctcgt ttcgggaaat tacgatgtca cttttggcac cggtcatccg 859801 gaaatcatga cagcggacga gctgcgccgt caatttcacg aaaaaggctt ttctgatatc 859861 gaagagctag tcatgcttgg cggaaaaaaa tatcgaagcg ttctaaacgc cgtcatcgga 859921 gaacaccagc atatcagctg gccgctatca tcatacaaag gcataggcta tatgctccaa 859981 gcgctgaacc gggctgttga agaaaagcat gaactgtagc acgtacatat gaggaaaaga 860041 gtgggaacat gaaaaaactt gtgtttggct tgcttgccat tgtgttattc ggatgcggac 860101 tatatatcta tcatgtatgg ttcggtgatc cattttcgaa aaatgctgca gaacagaagc 860161 tagtgtctta tgtgaaacaa acctatccta agaaagaaat caagatcacg aatggggtat 860221 ataacgctaa aacgtctgaa tatgtatttg aagcaacctc ccaatctcat cgctacccaa 860281 tgtgtacgaa gggatttctg catcctaaag taacgtgcga tggaattgaa gaagcgtata 860341 ccgaatcagt agcaaaacat gtaaatgaag aagcaacgaa ggcaatcgaa gcagatctga 860401 aaaaagcggt tcctcgattt ataaaagctg atgctgcttt gagtatcgaa aacggacagt 860461 tcacgttaga tacaaaatgg aacaaaaagc tggctgaaaa agcgcctatg agcatgacga 860521 ttcagttaga cgccagcggg ttatcaaaaa cagatgccgc aaagatggcg gaaacggtca 860581 gaaaaacgct taatgaaaag ggatatacat actcaaacgg cacgatagac tgtatgcaga 860641 aggacgggga cggcggtatt ggatatgtca aatattcaat tgattttctt tcaaaagcag 860701 ctattcagtc aaacgatgca gaggaactag gaagttaaaa agatttccaa ggaaataaat 860761 acgtcgatca ttgtcaaagg ccgggtgata tccggtcttt tttttgcatg ctgtaaaacg 860821 agacaaatga atcagtttga gacaaaacga gacacacgtc tcaaactgtc tccaaagtga 860881 agatgagaag actgatttta cgggctcaaa agactggcac acttcttgca tttataatgg 860941 tgaaccctaa atagaaggag gcgcacaaaa tgaaattgtt aaaacgagaa ggcttgtcat 861001 taactgagga aaaagcgctg tggatgtacc aaaagatgct ggagatcagg ggctttgaag 861061 acaaagtgca tgaactgttc gcccagggag tgcttcccgg attcgttcat ttatatgccg 861121 gtgaggaagc cgtggctgta ggggtgtgcg ctcatttaca tgatggcgac agcattacaa 861181 gcacccacag gggacatgga cattgtatcg ccaaaggctg tgacctggac ggcatgatgg 861241 cggaaatttt cgggaaagcg accggattgt gcaaaggcaa gggcggttct atgcacattg 861301 cggatcttga taaaggcatg ttaggcgcaa atggaatcgt cgggggcggc tttacgctcg 861361 catgcggatc agcgctcacg gctaaatata aacagactaa aaatgtaagc gtttgctttt 861421 tcggggacgg ggcaaataac caaggtacct tccacgaagg gctgaattta gcggctgtat 861481 ggaaccttcc tgtcgtattt gttgctgaaa acaacggcta tggcgaagct accccatttg 861541 agtacgcatc agcctgtgat tcaatcgccg atcgggcggc tgcttataac atgccggggg 861601 ttacagttga cggcaaagat attttagcag tttaccaggc agccgaggaa gcgatagaaa 861661 gagcaagaaa cggcggcggc ccgtctttga ttgaatgtat gacctacaga aactacggcc 861721 atttcgaagg agatgcccaa acctataaaa cgaaggatga aagagttgag caccttgaag 861781 aaaaagatgc cattcaaggt tttaaaaact accttttaaa agaaacagat gctaataagc 861841 tgtcagacat tgaacagcgt gtcagcgaat cgattgaaaa agccgtctcg ttcagcgaag 861901 acagcccata tccaaaagat tcggagctgc tgacagatgt gtatgtgtca tatgaaaaag 861961 gaggaatgta agagatggcg agagtcataa gcatgtcaga cgcgatcaat gaagcaatga 862021 agcttgcgat gagaaaagac gaaaatgtgc ttttgatcgg tgaggatgtc gccgggggag 862081 cggcggtcga tcatttgcag gatgatgaag catggggcgg tgtattaggg gtcacaaagg 862141 gactcgtaca ggaattcggg cgtacaagag tgctggacac tccgatttct gaggcaggct 862201 atatgggagc ggctatggct gcggcatcaa ccggtttgag accgattgcc gagctgatgt 862261 ttaacgattt tatcggcacg tgctttgatc aggtgatcaa ccaaggggcg aaattccgtt 862321 atatgttcgg cggaaaagcg caagtgccga ttaccgtccg caccacatac ggagcagggt 862381 tccgggccgc tgcccagcat tcacaatcgc tgtatggcct tttcacgagc atccctggac 862441 tgaagacagt tgttccatcc aatccgtatg atgccaaagg tcttttgctt gcagcaatag 862501 aagataatga tccggtgttt ttctttgaag acaaaacgtc ctacaacatg aagggcgagg 862561 tgccggaaga ttattataca attcccctcg gaaaagcgga tatcaaacgc gaaggcaatg 862621 atgttacgct ctttgcagtc ggcaagcagg tcaatactgc gcttgaagcg gctgcacagc 862681 tttcagagag gggcatcgaa gccgaggtcc ttgatccccg cagtctgtct cctctggatg 862741 aggatgcgat tttcacatcg ttagaaaaaa caaaccggct gatcatcatt gatgaagcca 862801 atccgcgatg cagcattgcc acggatattg ctgcgcttgt cgctgacaag ggctttgatt 862861 tgcttgatgc gccgattaaa cggattacag cgccgcatac accggttccg ttttcaccag 862921 tgcttgaaga tcaatatttg ccgacaccag ataaaattgt cagcgtcacg cttgaattgc 862981 ttggcgagcc ggcattgaat taaagggggg acacaaatgg cggtaaaagt agtgatgcca 863041 aaattgggaa tggccatgaa acaaggggaa gtatcgatat ggaataaaaa agtaggcgac 863101 ccggttgaaa agggagaaag cattgccagc attcaatcgg agaaaattga aatggagatc 863161 gaagcgcctg aaaaaggaac gctgatcgat atcaaagtga aagagggaga agaggttccg 863221 cccggcacag ctatctgcta tatcggggac gccaatgagt cggtgcagga agaggcgggg 863281 gcgcctgttg ctgaagacaa tatgccgcaa gccgtccagc ccgtcaaaca agaaaacaaa 863341 cccgcagcct ccaaaaaaga tcgaatgaaa atatctccag tcgccaggaa aatagcagaa 863401 aaagcaggat tagacctaaa acaactgaaa ggaactggac caggcggacg aatcgtgaag 863461 gatgacgtaa caaaggctct tgctgaacag aaaaaagatc aagcaaagcc tgtttcggag 863521 cagaaagcgc aggaaatccc ggtgacaggc atgagaaagg tcatcgctgc ccgaatgcag 863581 gaaagcctgg caaacagcgc gcagctgacg atcacgatga aagctgatat caccaagctt 863641 gccactcttc aaaaacagct ttcaccaact gcggaagaga gatacggcac aaaactgacg 863701 atcactcatt ttgtctcaag agccgccgtt ctcgctctgc aagctcaccc tgtgctgaac 863761 agcttttatc aaaatgagcg catcatcaca catccccatg tgcaccttgg tatggctgta 863821 gccttggaaa atggcttagt ggtgcctgtc atccgccatg ctgaaaagct atcgctgatt 863881 gaactggctc aatccatctc agaaaatgcc aaaaaagcac gcgagggacg tgcgggaagc 863941 gaagaactgc aaggatctac tttctccatt acaaaccttg gcgcgtttgg agttgagcat 864001 ttcacaccga tactaaatcc gccggaaaca ggcattctcg gcatcggagc aagctatgac 864061 acaccggtgt atcaagggga ggagatcgtc agaagcacga tcctgccact cagcctgaca 864121 tttgatcaca gagcgtgtga cggcgcccct gccgctgcat tcctgaaggc gatgaaaaca 864181 tatttggaag aacccgcagc attaatttta taggaaaagc aggtgaaaac gacatgacat 864241 tagccattat cggcggcgga cctgcaggct atgcggctgc ggtttccgcg gcacagcagg 864301 gcagaaacgt gctgctcatt gacaaaggca agcttggggg gacctgcctg aatgaaggct 864361 gcatcccgac aaagtctttg ttagaaagcg caaacgttct tgataaaatc aagcatgccg 864421 acagctttgg aatcgaactt ccggcaggtg cgatatcagt cgattggagt aaaatgcaaa 864481 gccgaaaaca acaggttgtc agtcagcttg tccaaggcgt tcagtaccta atgaagaaaa 864541 atcaaataca ggttgtaaag ggaacagcct cctttctttc tgaaagaaag ctcttgatcg 864601 aaggagaaaa cggaaaagaa atcagagagg cggaccaagt attgattgcc tccgggtcag 864661 agccaatcga gctgcctttt gccccatttg acggcgaatg gatcctcgac agcaaagacg 864721 cgctttctct ttccgagatt ccgtcttcac tagtcattgt cggcggcggt gtcatcgggt 864781 gtgagtatgc agggctgttc gccagattgg gatcgcaggt gaccatcatt gaaacagcgg 864841 accggctgat cccggctgaa gatgaagata ttgcccgtct ctttcaggag aaacttgagg 864901 aagacggtgt cgaagtgcat acttcatcca gattagggcg ggtggatcaa acggccaaaa 864961 cggcaatatg gaaaagcggt cagcgagagt ttaaaacgaa ggccgattat gtgctggtgg 865021 cgatcggcag aaaaccccgt cttgacggat tgcagctgga acaggccgga gttgattttt 865081 ctccaaaggg cattccggtg aatgggcaca tgcagacgaa cgtgcctcat atttacgcgt 865141 gcggagatgc tatagggggc attcagctcg cgcatgccgc tttccatgag ggcatcatcg 865201 ctgcttctca tgcttccgga agggatgtca aaatcaatga gaaacatgtg ccgcgctgca 865261 tctatacgtc cccggaaatc gcgtgtatcg gaatgacaga acgacaggca agaagcatat 865321 acggggatgt gaagatcggc gaattttcat tttccgcaaa cggcaaggcg ctcattaaac 865381 agcaagcgga aggaaaggtc aaaatcatgg ctgaaccgga attcggcgaa atcgtgggtg 865441 tctcgatgat tggcccggat gtaaccgagc tcatcggcca agcggcagcg atcatgaatg 865501 gtgagatgac ggcagatatg gcggagcatt ttatcgccgc ccatccgact ttatcggaaa 865561 cattgcatga ggcgctgtta agcacgatcg gccttgcggt acatgcataa taaaggaaaa 865621 agcaggcgca tggatataag gcgcctgctt ttttattgtt gaaagcgctt tatttttccc 865681 ctacaataga tgaaaacggc gtgtaaggga ggagcgatca aggaaatgaa ttcggtccca 865741 aacgatttgc aaacctggaa acgttttgtg aaagacggtg tgcttgacga agcccgatta 865801 agaaaacgga ttgcagagtc atggcatcgc tgcaaaaaag ctgaggtcaa tccttattta 865861 gaaaaaggcc cgaaggtttt acagcaaacg gagctggatc agcagtcaaa aaaacattca 865921 ttcttcttga cgaccgcaaa gccttacctc gaaaaactgc tgcctgccat aaaagaaatg 865981 gaaatgatgg cgctgttaat tgattcagac ggtgttgttc tggcattgga cggccatccg 866041 cgcgcgctct atgaagccaa acgcatcaat ttcgtcgaag gggcatgctg gacagaaacg 866101 gctgtcggaa caaatgcgat tggcacggcg ctccacatca gcgagccggt tgcaatacaa 866161 ggatcagagc attactctat cgcttcccat ctttggaact gttcagctgc tccgattcac 866221 catgaggatg gcagccttgc gggtgtaatt gacatatcat gcccggcggc aggcgcgcat 866281 cctcatatgc ttggtattgc cacggcgatt gcctatgccg ctgaacggga actcgcagct 866341 aaaagccgtg agaaagagct ggagctgatc agccgttttg gggagagagc tgcatccagt 866401 gtgccgatgg tgctctgtaa taccaagcag cacatcatca gtgcgagcat gccgattcga 866461 acctcaatgc cggattggca gggccggcac ctgtacgagt tgaaggaacg gggctattca 866521 atcgaaaatg ctgtcaccat aggagatggc ggcacttgtt tttatctttc ggaacaaaag 866581 aaaaagaagg cgtttcgatt caatggagtg atcgggcaaa gcggccgatc gcaagcgatg 866641 ctgatgcacc ttgaacgagc agctgcgacg gatgcatcgg tctgtttgtc gggtgaaacg 866701 ggtacgggga aggaggtcgc ggctcgcgcg cttcatgaga acagtgagag acggcacggt 866761 ccgtttgttg ctgtcaattg cggagcgatt ccgtctgatt tgattgaaag cgaactgttc 866821 ggatatgcag agggcgcttt tacgggagcg aaacgaaatg gctataaagg cgcctttcaa 866881 aaagcgaatc aaggcacatt atttttagat gaaatcggag aaatttccca ctcgatgcag 866941 gttgcacttt tacgggtgct tcaggaacgc aagataacgc caatcggcgg gacgaaagaa 867001 attccggttg atatcagagt tattgccgcc acacattgtg atttacgcga gcttgccgaa 867061 aacggaaaaa tcagagagga cttgttttac cgtcttcatg tctatccaat tgaactccct 867121 ccattacgcg atcgcaccga ggatatcccg gatctctttg agtactacaa acagaagaat 867181 cattggccag gcgatcttcc ttctgatttt tgtaatgtgc tgaagcaatg gaagtggccg 867241 gggaatatcc gcgagctgtt taatgtgttt gaacgtcttt ctatcagatt tccggacggc 867301 cggctgagag atgaatcgct tcccgcttta ctggaagccg ctggattgcc ggccagctct 867361 gcagaaaaaa agccggctgc tgccggcgtg cttacttttc gtgagcaaat ccaaaaggat 867421 atgatgatca aagcgcttga atctgcaaaa ggaaacgtct ctcaagccgc aaaaatcagc 867481 gggatccccc gaagcacttt ctacaaacgc ctgaaaaaat tcaacttgtc cgctgaatca 867541 taaagcatac ttccttcagg aaatggaaac gttatgtatt gaaggagggt gttacgatga 867601 atattcaaag ggcgaaagaa attgtagaat ctcccgacat gaagaaagta acatataacg 867661 gcgttcctat ttacattcag cacgtaaatg aagaaactgg aacagcaaga atttatccgc 867721 ttgacgaacc gcaagaggag catgaagtgc agctgaacag cttaaaagag gattaaacaa 867781 aaatggcccg cttcataagc aggccatttt gttatccgcg cggcgcaaat aaaataacac 867841 agacaccgat gagacaaatg aatgcgccga tccagtcata cagatcaggt gttttccggt 867901 caacaagcca tccccacagg accgcaagca cgatgaatac tccgccataa gcggcgtata 867961 cacggccgaa agatgggaag gactgaaacg tcggaagaat gccgtataca atgaggatca 868021 gcgccccggc gattccgtag ccagctggct ttgcctctct cagccatagc caaaccagat 868081 atccgccgcc aatttcagca agccctgccg cgagaaataa aagaatggta atcagcatca 868141 tgagcactcc tcaatttgca tttatctttc attatagagg aggagagctt ttaaagcttc 868201 ggatgattct caaattcctt caaatacgct tttcgctgaa cctctgtaaa ttggctgatc 868261 caattgtttt gagcctcttc attcaaatgg ggaaggatat agcgttcaac cgcttcgaaa 868321 aacagcggat tcgtgatgat gttccaggtc gggattcgaa cgattttgcc gtctgttttc 868381 tcgatgataa tatcctcaaa aaagatccct ttcaaactgt attgatggcg tcccatataa 868441 agccgcttca cctcggaaaa cagcacgctg cgctttctca agaagatttc gccactaggt 868501 ccggtcttta tggtgaaaat gacatttcca cggcttgtga acgcaggaaa agccataaag 868561 aatgtgatca atccataaat catcgccagt aatccgccgc ccaaataaag cagggcatat 868621 ttagattcaa acgtgagggc ttcagacacc agccagactc ccacaataaa ggcgccccct 868681 gtagcgagga acagccaagc ccttagaaac atcatgcttt ttacttcaat catgtgctgc 868741 ccctaaagct tcggatgatt ctcaaattcc ttcaaatacg cactgcgttg gatgtctgta 868801 aactgtccga tccaattgct tttcgcctct tcattcagat gtggaaggat atagcgttca 868861 accgcttcga aaaacaacgg attcggaatg atgttccaag tgggaatgcg aatggtcttc 868921 tgatccacgg tttggatcaa tatatcttct tggaagattc cttttagact aaatttatgg 868981 cggctcatct caattttctt gatatcagta aacgtaacag acactttgtc agtgaacact 869041 tctccatttt ttcctgtctt gatgcggaaa atggtatttc cccgcggggt gaaagccgga 869101 aagaagatga taaataaata taaacaaaac aaggtgaaca gaaagccagc aggaatggct 869161 aataggtaat atttcgtttg aaacgtaata cccatataaa agagccacaa acatgctaat 869221 cccataccgg cagatccgac aaaagcccat attctcagga acattttgct tttgacttca 869281 atgatttctt ggtttttcaa tgcttttctc cttttgttaa ttcaattctt atcattttga 869341 aatgatttga tttacaacat ccttatgagc agggaggata gaaaattcat tctgggtgat 869401 gcctgtgaca agccaagtat ggtgggcccc cggcaggacg aatgccatgt cagccacttc 869461 aggagtgtta tcttttccat atgccagacg cataagtgta tccattttcc ctttccgcaa 869521 agccagatca tttgcaaatc gggtaacgtc ctcttggtgg tcatgttttt caaggaactc 869581 ttttagatat gaagggttgt ctgaagcgcc ctccaagagt ttttcaaatt catttgatgt 869641 caatgttaca atcgattctc ttttatcctc tgtatctatt atatgtaaaa actcatctgt 869701 cttagcaagt aacccttcac ttgattccat ttttgtaatg cgatggactt gttcatcaaa 869761 aaggagttcg tgagagtagg tgccgaattt tgatacatgg catgacacat tctgttcggc 869821 accttgcccg ttaaatttag aaagcttcac tgtatagtca gcgtcgttta atacatggat 869881 aaacggacag tactcgtcct ttaaccgata ttgatggttc cgatattccg ctgcatcctt 869941 ggctaagagt gagcggcacg cggcttcaaa taaggcgccg agctgttcat cttctatttc 870001 cggaaaatag gcctgcttca aggccattcc ctgttcaaaa aacccttcgc tgtaaaagca 870061 aaacaagagt tcttctatgc taattgtaaa ctgcttcatt gtttattctc ctatccaaat 870121 gaaaatttcc ctttaaggaa atgggttgcg ccgtgtataa gcgaatccgc tgttttcttt 870181 gctttttcca ttcctttttt cgcgctgtct atccctttat gtatcgattt attcgccgca 870241 tctatgccgt cattcactga tttgacgact ttgccggctg attccagccc ttttttggct 870301 gtatcaacaa cagcatggat cggttctttc agctttaagg ctgctttttc agcaaaaccg 870361 gctgtatatt tggcgatttg ttctccgacg actccgccaa tgtatgaacc tgctgcccca 870421 agaaggacag tacccacagg tcctgcaaag cttccgattg caccgccgat gacagcacca 870481 gctgtggcac cgccggcaac aaaaatcgta ttattcacag cattcccgac ggccttggcg 870541 ttttcacgct tgagaacttc cggtttatcc tggtattttg cataattttc agcaattttc 870601 acgcctgctc cgaatgtttc ggtcgctccg gtaatcagtg tggcggtaat ggcatttcct 870661 ttcgcgaatc tcaagcccgt ttttcccaca tccttcaaag tggagcgtac gccggcttca 870721 ttaagaaatc cttttgtgta gcttctgacg ctgtttgaaa aatccaccgt gtcctgagga 870781 aagtattttg taaacttttt atgtaccaaa tctgaaaatg gacggtttgt ctttttcaac 870841 aaatatttag gattcaaaag cactcttgcc gctttttgat aacgtgagct gtcaacggcc 870901 ctggaaatat ccaagagcag ttttgagtgc tgggctgtat gcaagccgct tggttgtttc 870961 acaaatttcg taagccctaa tccgtaatat tttccctgcg tcagcataag agcggttaag 871021 cttgtcatcg taccgtattt gtcgtaggca ttgtagagct ttcgcaaaat atcatcttgt 871081 tccacaaatt tatcgcctgt ttttctgatg aaaatctcat tgtcactcag cttagtgacg 871141 agcgcctttc ctgagctcca cgcatcgccc actccagaaa aacagctgct gtagcgggga 871201 tcgcattgca aaatcatctg ccccagctcc acatgcaggt ccttatattt gttttccata 871261 tcagttaatt cagtgactac atcatttgca agctgttcga gcttatccgg atcaactgca 871321 atgtttcctg acacaccgtt cacctcccga gtttatgtct ttcctctctt gctttacgct 871381 ccagttcttc cattctggca atttcagctt ttcgttcttc tattttgaca gcggcagcct 871441 tcagctcttg gcttgtttca agcagctcct gttcgaattg atcgtaggcg gctttcgttt 871501 cctcgaaatc ctggtcaaac gaatctcttg ctttgccctg ccaagcatct cccaatgcag 871561 ataaccggga ttcaagcagc attttggagc ttctgacctc ttctgcggcc gcactatact 871621 tgtttgccag ctcaatgact ttatatgagt ccaacttttg tcccctgcct tttctaaatt 871681 cacgcacaat tggatgtttt atataaatga ttataaataa ttcggcatgt atccgaatcg 871741 tacaaaagaa ccttttcata agaattggaa gggcgtatat tcacttaaaa ttcacagttg 871801 gtgagacttt aagattacaa aaaaggtaaa aaaaccaaat ctctcagaca taaggcaaat 871861 gagaaatttc ccgctctatg ggaaaaaaca ctaaagttga tcaaatgacc taagtgcgcc 871921 aaacgtgtta cgggacgagc tatctcatgg tataaatgga attgtaaacg ttatcaagga 871981 ggtcgtcata tgaagaaaaa atcattctca atcgtaatag cgggcggagg gagcactttc 872041 actccaggga tcgtactcat gctcttggac catttggagg agtttccgat cagaaagctg 872101 aagctgtatg ataatgataa ggagagacag gatcgaattg caggcgcctg tgacgttttt 872161 atcagagaaa aagcgccgga tattgaattt gcagcgacga ctgacccgga agaagctttt 872221 acagatgtcg attttgttat ggcgcacatc agagtaggga aatacgcgat gcgcgcgctt 872281 gatgagcaaa ttccgttaaa gtacggagtt gtcggccagg agacgtgcgg gccgggcggg 872341 atcgcatacg gtatgcgttc gatcggcggt gtgcttgaaa tattagatta catggaaaaa 872401 tactcgcctg atgcgtggat gctcaattat tccaatccgg cggcaattgt ggctgaagct 872461 acgagacgcc ttagaccgaa ttctaaaatt ctcaatatct gtgatatgcc ggttgggatc 872521 gaagaccgga tggcgcaaat tcttggctta tcctcaagaa aagaaatgaa ggtccgctat 872581 tacggattga atcatttcgg ctggtggaca tcgattcagg atcaagaggg caacgattta 872641 atgccgaagc tgaaggaaca tgtatcccaa tacggttata ttccgaaaac agaggctgaa 872701 gctgtggagg caagctggaa tgacacgttc gccaaagcgc gtgacgtgca ggctgcagat 872761 cctgacacac tgccgaatac gtatttgcaa tattatttgt tcccagatga tatggtgaaa 872821 aaatcaaatc cgaatcatac gcgggcgaat gaagtcatgg aagggcgcga agcttttatt 872881 ttcagccaat gtgacatgat cacacgtgaa cagtcctcgg aaaacagcga aattaaaatc 872941 gatgaccacg catcgtatat cgttgatctt gcccgggcga ttgcctacaa cacaggtgaa 873001 agaatgctgt tgattgttga aaataacggt gcaattgcga actttgaccc gactgcgatg 873061 gttgaggtgc catgcatcgt cggctcaaat ggacctgaac cgattaccgt tggcaccatt 873121 ccgcaattcc agaaagggct catggagcag caggtatccg ttgagaagct gactgttgaa 873181 gcgtgggcag agaaatcgtt ccaaaagctg tggcaggcgc tgatcctgtc aaaaacagtg 873241 ccgaacgcgc gtgtggcaag actcattctt gaggatttag tggaggccaa caaagacttc 873301 tggcctgagc ttgatcaaag cccaacccgc atatcataaa tgaaattccc ccattttcga 873361 atctgtaatt gtatataata gaaagaaaat ggggggatct gatatgcagc tcgaagaact 873421 gatcaatcag cactacagca aattgaatga caacgatttt catattttaa aatatatatt 873481 gaatcataag cacacatgct atcaccttgg aatcgacgcg ctggccaaag cttgcagtgt 873541 atcgcgttcc tcaattttac ggcttgccca aaagctcggt ttcagcggtt acagtgaatt 873601 tcgcgtcttt ttaaagtggg aagatcagcc ggaagaaggc gagagtatga gttttgaaaa 873661 gctgcttgat gatattgaag caaatttgaa gtttttacgg acaaaggaca tgacggacat 873721 gtgccagctg attgatgcag ctgaccgcat tttcgtctac ggttctggaa atgcgcaaaa 873781 gatatgcgcc cgcgacctgc aaagaatgtt tattccgcgc catcgctatc ttattttgat 873841 tgaagacaca aatgaattta atttgatgcg cgatgatttt aaagtgaacg atctgtttat 873901 catcatttct ctttccggag aaacaccgga gctgattcct caggcaagaa tgctttctgc 873961 aaagggtatt ccctttattt ccattacgaa tttaaaaaac aatgtcctcg cccagctgac 874021 tccgcataat ctttatgcga caagcaaacc tgtgacatta agcgatagaa cggaaattgt 874081 cgcttttgca ccgttttttc tcgttggcga agcattgttc cgcgcatatg ttgattacaa 874141 agaggcagaa aaaaatgaca atgagtagca gggggttctg gtatgatgca aaaaattcag 874201 cgctttggaa gcgcgatgtt tgtgcctgtt ttattattcg cgttcgccgg cattatcgtc 874261 ggtatcagca cgctctttaa aaataaaacc ctcatgggac cgctcgccga tcctgacggt 874321 ttttggtatc agtgctggta tatcattgag cagggcggct ggactgtttt taaccaaatg 874381 ccgctcttat tcgccattgg catcccggtt gctttggcga agaaagctca ggcacgcgcc 874441 tgtttggaag cgcttactgt ctacctgaca ttcaactatt ttgtcagcgc gatattgacg 874501 gtatggggag gagcatttgg cgtcgacatg aatcaagagg tcggcggaac gagcgggtta 874561 acgatgattg cgggcataaa aacgctcgat accaacatca tcggagccat ctttatttct 874621 tcgattgtcg tctttttgca taatcgctat tttgataaaa aactgcccga ttttctcggc 874681 atctttcaag gctcaacata tatcgtgatg atttccttct ttattatgat cccaattgcg 874741 ttggctgtgt cttatatttg gccgatggtt caatcgggaa tcggctcgct tcaaagcttc 874801 ctggttgctt ctggggcggt gggcgtttgg atatacacgt ttttggaacg gattttaatt 874861 ccgaccggcc ttcatcactt tatttacacg ccgtttattt atggcccggc tgtagcggaa 874921 ggcgggatcg tcacgtattg ggcacagcat ctcggcgaat attcgcaaag cgccaaaccg 874981 ctgaaggagc tctttccgca aggcggattc gcgcttcacg gcaactcgaa aatcttcggt 875041 attccgggta tcgccctggc tttttatgtg acagccaaaa aggaaaagaa aaaactcgtc 875101 gcagggctgc tgattcctgt cacactgaca gcgattgtcg ccggtattac agagccgatt 875161 gagtttacgt tcttattcat ttcacctttc ttatttgcgg ttcacgccgt gcttgccgcc 875221 acaatgtcga cagttatgta tatggccggc gtcgtcggaa atatgggagg cggactgatt 875281 gaggcggtaa ccttgaactg gattccgctc tttggcagcc acggtatgac atatgtgtat 875341 caaattttga tcgggctctc gtttacagca atttattttt tcgtcttcag atttttaatc 875401 ctcaaattca atatcgctac accaggacgg gaaaaggatg aacagcagga aacaaagcta 875461 tattcgaaaa aggaatacag agaacgaaaa aacaaggatg aaacggcctc cgctgctgaa 875521 acggctgatg acaccgcttt tctgtatatt gaagcgctgg gcggaaaaga caacatcact 875581 gaagtcacaa actgcgccac ccgcctcaga gtcagtgtca aggatgaaac aaaggttgaa 875641 cccgacagcg tattccgcgc gcttggcgca cacggcgttg tcaggaacgg gaaggcgttt 875701 caggtaatta tcggattaag cgtgccgcag atgcgggagc gtgtggaaaa aatattgaat 875761 caataaagac tgccctcctt ttcgggaggg ttttcgtttg ccgtcaaaaa gaccgccata 875821 gtaaagtaaa gaaagagaca atcgagtaaa aaggggtttg gaggctttta catgcaaaag 875881 gctttgtcgt ttttaaaacc atattcattg ctggcgggaa ttgctctgat tcttatgctg 875941 acggagcttg cagttgaact gatgcagcct ttattgattg caaaaatcat cgacgatggg 876001 atattgaagc aagatctgcg gcatgtatgg atatggggca cggtcatgat cgggctgacc 876061 gtgttatcct ttgcggcggg gatgctgaat tccttttatg ccgcccatgt cagccaaagc 876121 ttttcctatg atacgagaaa agggcttttt caaaaaatcc agtccttctc ctattccaca 876181 tttggacagt tttcgtcctc ttcttatatt acaaggctga caaacgacgt cacacaggtt 876241 caaaatatga tttttatgag tttgcggttt atgctgcggg ctcccttaat gattgcaggc 876301 ggcattgtgc tgtcgcttgc cgttaatgtg aaactcgggt tttttctgct tgtgaccatt 876361 ccgatcctga tcttgttttt gctatgggta ttaaggaaag gcggggcact gttccgctca 876421 gtgcagaaaa ggctggatca agtgaacacc atcatgcagg aaaatttaat tgcaatcaag 876481 ctgatcaaag cgctgcttcg cggcagccac gaagtcaaac gatttatcaa agccaacaca 876541 aggctgatgg aaaaaacggt ttcggccttt cagcttgtgg aattcacgat gcctgtactg 876601 atgctgctga tgaatctctg catccttttg attttgtggg cggggtccta cagtattacg 876661 agcggaagca ctcaggttgg cgatgttgtt gcgataatta actacgcaac acgaattaca 876721 ggcgcgcttt cgatgtttcc gtttttgatt atgattttca cccgggcgaa ggcttcaggg 876781 gatagaatcg gtgaggtgct tgaaacagaa ggcgacgagc gggaggaagg caccatatct 876841 gatcgtttgt caggacggat tgagtttcag catgtatcct ttcgctatcc tgaaatggac 876901 agagaagcgc tcaggaatgt ctcattttcc gcaaagccaa gagaaacgat cgcgattctc 876961 ggtgcgacgg gctcgggcaa gtccacgctt tttcagctca ttccgcggct ttatcagccg 877021 gattcaggcc gcatttacat agatgaaaag ccggttcaag atattccggc tgaagggctg 877081 cgcaggcaaa ttggatatgt accgcaggaa gtcctcttgt tttccggcac aatcaaagaa 877141 aacatcgctt ggggcaaaga aaatgcttca ctagatgaaa taatggatgc ggcaaaactt 877201 gcgcaaattc atgaaacgat tttaaagctc ccaaatggat atgacactgt tttggggcaa 877261 agaggcgtca acctgtccgg cggccaaaag cagcggattt ccattgcgcg ggcgctgatt 877321 cgaaaaccgg ctatccttct attagatgac agcacaagcg cgcttgatct gcaaacggag 877381 gcgaagctgc ttgaagcaat cagcacatac cattgcacaa ctttgatcat tacacaaaaa 877441 ataaccacgg cgatgaaagc tgatcagatt ttgctgcttg aggacggcga actgattgaa 877501 aaaggcactc acagtgagct gctttctgaa tctcagttat acaagcgcat ttacgagtca 877561 caattcggaa gggaggggag cgagtcatgc taaaagacat ccgcaagcct ttccaatatc 877621 ccaaactgcc aattgacaaa aaagaaggcg cgaaaaagcg ggcgaaagca aaggatacaa 877681 agggcacact gagacgaatc tggtcttact tggctgaaag aaaaggactg ctcatacttg 877741 tcatgctaat ggttgtcatc agcgccatat tcggactcct tggtcccttt gtgatcggaa 877801 aggccatcga ccattttatc gtcgggaaaa cggtcagcgg cttgattcct gttttgcttc 877861 ttctgctcgc tatctatatc attcagtccc tgtcgctttg gtttcaaaac tattggatga 877921 ttacgatctc gcagggcacg gttttcagaa tgagaagcga attgttcacc catctgcatg 877981 agctgccgat tccatttttt gataaacagc ggcacggcga gctgatgagc cgggtgacga 878041 atgacatcga aaatgtcagt tctaccttaa acacgtcagt cattcaaatt ttgtcaagtg 878101 tgatcacctt tgtcgggacg attgcggtga tgctgtacat gagcccgctc cttactttga 878161 ttacgctgac cattattccg gtgatggcag cgagcctgaa atggatcacc aaccgaacgg 878221 gaaagctgtt taaagaacag cagaaaaacc ttggtgatct gaatgggtat attgaggaat 878281 ctgtttcagg cgcaaaggtc atcaaagcat attcacgtga gaagcagatt actgctgaat 878341 tcctcgaaaa aaacgctgca ctcaagacgt cgggcttttg ggcgcagacg atttccgggt 878401 ttattccgaa ggtcatgaac tctttgaata acttaagctt tacaatgatt gcggcaatcg 878461 gcggtttgtt tgcgctgaaa ggctggatct cgatcggctc catcgttgtc tttgccgagt 878521 attcaagaca atttacacgc cctttaaacg atctggccaa ccagtttaat acgatgctgt 878581 ccgcaatcgc cggcgctgaa cgggtgtttg acgtgcttga tgaaaaagaa gagcgcgagg 878641 atgaaaagaa cgccgtgcat cagcccatcc aaacaggcag cattgaattc cgggatgtgt 878701 ccttcggtta cgataaaggg cagcagacac tgaagcattt acagtttacc gtgcctgcgg 878761 ggcagtccat cgcgtttgta ggaccgacgg gggcggggaa gacaaccgtc actaaccttc 878821 tcgcccgttt ttacgagcct aacgatggaa aaattttaat cgatggtaca gatattaaaa 878881 cccttactag agcaagccta agaaaaaaca tggggtttgt tcttcaggat tctttcttat 878941 ttcagggaac gatcagagaa aacattcgct acggcaggct tgatgcttct gatcaggaag 879001 tcgaagccgc tgcaaaaaca gcgaatgccc atagttttat tgaaaggctg ccaaaagggt 879061 atgacaccgt actgacgcaa aacggttcgg gcatcagtca agggcagaag cagttgattt 879121 ctatagcgag ggcggtgctt gccgatccgg ttcttctcat tttggatgaa gcgacaagca 879181 acattgatac cgttacagaa gtcaacattc aagaagcgct cgcccgttta atggaaggaa 879241 gaacaagcgt catcattgcc cacaggctga acaccattca aagagcggac cagattgtgg 879301 tgctaaaaaa cggtgaaatg attgaaaaag gcagccatga cgagctgatt cggcaaaaag 879361 gattttacag tgacttatat gaaagccaat ttgagaaata gacctttgtc ctgcacagag 879421 gtcttttttt gttacagttt tatagtactt ttatttcatt ttcgtaaaat gtaacaaaat 879481 tacttgacgt aaacaagtta tgtatatata ctagcttaca ttaagtaagt gataacattt 879541 atcaaggagg ataaaatgaa taaatcattt gaaattggca cattactttt aagagttatt 879601 acaggtatta tcttttttgt tcacggttta tcaaagtttc agggaatgga gggcaccatc 879661 caatttttcg gcagcatagg ccttccaagc tttatggcgt atgtcatcgc agcgattgaa 879721 ctgattggcg gagtgcttgt cttcttcgga ttggctacac gtattgtcgg tgtactgttc 879781 gctcttacac tgatcggcgc catcatcact gttaagctga aagcgccatt catgggcaat 879841 gcagaatttg attaccttct gcttttgaca tccattcacc tggcgcttac tggaagtcga 879901 ttcctggcgc tggacccatt tgtgtttaaa ggaaaaaaga acggaaacgt ttcagcataa 879961 gaaaagaggc atgcagcatg accagcattc atgaggatac acacattggc tatgccaaac 880021 tcacaattcg cagtctggag cgttcgcttc agttctactg taacgtcatc ggttttcaag 880081 tcttaaaaaa gacggaccgc caagcggaat taacggctga cgggaaacgc gtactgctta 880141 ttcttgaaga aaatccgagc gctgtcgtct tgcctgaacg gtctgtgaca ggcctttatc 880201 actttgcgat tcttcttccg gacaggaaag aacttgggat cgcgctcgcc cgcctgattg 880261 aacacggcat tgctatcgga catggagacc atgctgtcag cgaagcgctc tacctgtctg 880321 atcctgacgg aaacggcatt gaaatgtacg ctgaccgccc ccgcagcacg tggcagcgtg 880381 atcgggaagg aaactacgtc atgacgacaa ccgctgttga cattgagggc cttctggaag 880441 aggcaggaga tgagcggaaa acatcgcttc cgaacgatac aatcatcgga cacattcatc 880501 tgcatgtcag tgatttgaaa gaagcaaagg cgttttatac agatgtactg ggctttgaca 880561 ttgtcggaaa ctatgcgggc atgtccgccc tcttcgtttc agccgggggg taccaccatc 880621 atatcggctt aaacatttgg gcgggaagaa atgcgccgcc taaaccgaca aatgccagcg 880681 gactagatta ttatactgtt gtcctgcccc accaagagga gctggatttg gtggcaaacc 880741 gagtcaaaca tgccgggtat tcgattgaag agacggaaaa cagctttcgt gtgaaagacc 880801 ctgtttccgg cgcctatatt acatttgtga tttaactgca atccccttgc cgaaataacg 880861 gcagggggat tttttatttt tgtccgcctt gttatgatga gagaaccaac ttgttaggag 880921 gcgtttacat ggaactcaac caccttgtga cgggcaaaat agcattaaat caatatgtgc 880981 atcgcttaga gcaaaaggat gtttcatttt acgtccacta ctggggagcg atgacgaacc 881041 actataacac actgcttcat aagcattcct tttatgaaat ttgttacgtg gtaagaggtg 881101 aaggatatta ccttgaaggc gatcgtacat atccgcttcg tgaacagacg atttttttgt 881161 caaagccgga gcatttgcac caaatcaaaa gtgaaacagg gctgttcctt ttttacgtcg 881221 ctttcgagct gagcgaggat cagtcaagcg ccgaatggat caaagtgatg gaagaagtga 881281 aacaaagccc ctttatcaca atgcaattga aagatggcga accgccgggc ctgctttgga 881341 aaacgttaat gctgcaagca gcgcaacctg tcaatgcttt tgacaaagag atcctatctc 881401 atttgtcgca tgcattgatc ctgtcattaa tccaaacctt tctcccgtac gcccaacgcc 881461 cgaaacaaaa gcagcccatt cacacatctt ctgctttgct gacagaggtg aaactgcaca 881521 taaaagacaa tctgtcacag ccgttaaagc tgacggatgt cgctagccac tttcatatct 881581 cagggaggca tttatcacgt ttatttgcag cagaactggg cgtcagctac tcagaatttg 881641 tccaaaatga aaaaataaac aaagctgccg aactgctgaa atcaacgaat ttgtcgatta 881701 aagaaatagc ggaagaaatc ggtttctcag tacattattt cactcgcgtc ttttccgcta 881761 aaatcggcag ctctccaggg cttttccgct ccctttataa agactcaaaa atgaccgcat 881821 ttcaaatcaa taaacctttt caaaaaatcg aacaggccaa gccgcacgaa taagatgtcc 881881 tgaaatgaca aaacaatgtc ttcatatgat aaagacgcga gaaatctcgt tgtcttataa 881941 tctttttaga aagcggttac aacaaggggt attgctgaag gagggatgca ttggcttatg 882001 cttggtgtcg ggtgctctgc cattcttgaa agaaggggaa gaaagccgtg agtacaaaaa 882061 agaaagaggc tgtaatagga aaagaaagct tagctcataa agggctttta cgaacgatta 882121 cattggtatc tacattcggc ggcctgttgt tcggttatga tacgggtgtc attaatgggg 882181 cacttccttt tatggcaact gcaggtcagc tgaatcttac acctgttaca gaaggactgg 882241 ttgcgagttc cctgcttctc ggggcagcct tcggggcgat gtttggagga cgtctgtccg 882301 atcggcacgg ccgccgaaaa acgatccttt atttagcctt actcttcatc gcagccacac 882361 ttggctgtac cttttcacca aacgcgtccg tgatgattgc ctttcgtttt ctgcttggac 882421 tggcggttgg ctgcgcttct gtaacggttc caaccttttt agcggaaatt tcgccggcag 882481 aacgcagggg acgaatcgtg acacaaaatg aactgatgat cgtaattggc cagcttctgg 882541 catacacctt taacgccatt attggcagca caatggggga gagcgcaaat gtatggcggt 882601 atatgctggt catcgcgaca cttccggctg ttgtgttatg gttcggaatg ctcatcgtgc 882661 ctgaaagccc gcgctggctg gcagctaaag gcagaatggg tgacgccctg cgggtgcttc 882721 ggcaaatccg tgaagacagt caggcacagc aggaaataaa agaaatcaaa catgcgattg 882781 agggcacagc aaaaaaggcc ggctttcatg attttcaaga gccgtggata aggcgcattc 882841 tattcattgg gattggaatc gccatcgtac agcaaattac cggtgtcaat tcgattatgt 882901 actatgggac agaaattctg agagaagccg gttttcaaac agaagctgca ttaatcggca 882961 atattgcaaa cggtgttatt tcagttattg cggtcatttt tgggatatgg cttctcggca 883021 aagtccgtcg ccggcccatg ctgatcatcg gacagattgg cacgatgaca gcccttctgc 883081 tgatcgggat tttatccatt gtccttgaag gaacacccgc cctgccgtat gttgtgctga 883141 gtttgaccat tttgtttctt gcgtttcagc agactgccat ttctacggtg acgtggctga 883201 tgctctcgga aatctttcct atgcatgtgc gggggcttgg catggggatc agcaccttct 883261 gcttgtggac agctaacttt ctcattggat tcacctttcc cattttgctc aatcatattg 883321 ggatgtcggc gacatttttt atctttgtcg ctatgaatat cctagcgatt ctatttgtga 883381 aaaaatatgt gcctgagaca aaagggcggt cacttgaaca gcttgagcat tcctttcgcc 883441 agtatggccg ccgcgctgat caggaaatcc aaaatcaaac aactcactta tcgtaacctg 883501 agataccagg aggaatctat caatgaaact atcttatgta acagacagcc tagggcattt 883561 gccttttgaa gacatgctca attttgccgc aaagcttggg atcgatacac ttgaaatgac 883621 aaccgggggc tggtcgccgg cacctcactt gaatcttgat gaattgctgc aaagcagcga 883681 aaaaagaaaa gaattttcac aagcgctgga aaagcggaac atgacacttt gcgcattaaa 883741 ctgctcgggg aaccctttag atccgggtga attgggcaaa tcgcacagag acataactga 883801 caaaacgatg gagctggctg gattattagg cgtcaaaaaa gtgatcatga tgagcggttt 883861 gccagccggc ggcccggacg acaaagtgcc gaactggatc acatacacag taagctggcc 883921 tcccgtttta aaagatatcc tcaactatca atgggaagac gttgcgatcc catattggaa 883981 gaagcttgtc aaaaaagcgg aggcctgcgg cgtggggaaa atagcgcttg agaacttcag 884041 ctctcaatta gtctataatc ctgagactct ctttcggctc agaaatgcag tcggcccgat 884101 ggtcggtttg aatcttgacc cgagccattt gttatggatg ggcgcagacc cgatcatcgc 884161 agcaagggag ctcggctcag ccattcacca tgtccatggg aaagatgtca gaattgaaag 884221 atatttatcg gcggtcaacg gacttttaga aacaaaagaa gtgacagatc ctgcaaaccg 884281 ggcgtggaat tacgtagctg tcggctgtgg acaggattta cagtggtgga aggaattttt 884341 ttcagttgta aaaatgatgg gatatgaagg tgaggtttct ttagaaatgg aggatctgac 884401 gatgtcacct gaagcgggca tccgtacttc tgtagaagct ttaaaacaaa ccatcagcca 884461 ataggaggtt ttcatgatgc taaatggaga aagaatcatc tctaagccgc ttcgctgggc 884521 aatggtaggc ggcgggcggc tcagccaggt tggatataaa catcgtattg gagcgctgag 884581 agacaatact gcttttcaat taactgctgg cgcttttgat atcgatgccg aaagaggaaa 884641 agatttcggg gtgaaccttg gagtggatgc ggaacgctgt tatcccaact atcaaaccat 884701 gtttgccgag gaagcgaaaa gacaggatgg catagaggta gtatcgattg ccactccgaa 884761 cggcactcat tatgagattt gtaaggcggc gcttgaagca ggagtgcatg tcatctgtga 884821 aaaaccgctg ttcttcactt cagcagaggg gcaggaaatc aaagcgctcg cagagaaaaa 884881 agggaaaatt gtcggcgtga cgtacggttt ttcaggcaat caaatgcttc ttcaaatgcg 884941 tgcgatgatt gaacaaggaa tgatcggcga tattcgcgtg gttgacttgc agtacacaca 885001 cggtttttgt gcaacagatg aaggtgaaaa gataagcgct gcacagaaat ggcgtgtcga 885061 ccctgcgatc gccgggccaa gctttgtgct gggcgattta tctacccaca cgtattatat 885121 gtcacagctt attatgccaa agatgaaaat taaggagctg ctgtgtgacc gacagagctt 885181 cgtcggcagc cgcgcaccgc tagaggataa tgcccatgtg ctgatgcatt atgaaaatgg 885241 agcggtcgga acgatgtgga catcgtcaat caatgccgga tgtatggatg gccatagaat 885301 ccggattgtc ggctcaaagg caagcattga gtggtgggac agcaagccaa atgaactgac 885361 gtatgaagtg cagggagagc cgggccagac actcgttcgc ggcatgccgt atttagatga 885421 tgtttgcaac gccgatgaac gactgggcgc cttacacagc gaagggctgt ccgaagcatg 885481 ggccaatatt tatcttaaat ttgccattgc gatagacgcc aaaaaccgtg aagatgaaga 885541 aatcttgaac aacttggttt atcctgacat tgatgcaggg atcgagggca ttcgctggat 885601 tgagaactgc gtgcgctcgg caaaccaagg gtcagtttgg gttgaattta aataaatgag 885661 ggaatgcgcc gcatatgaca taaagttcat atgcggtttt tattttccag aaactcctgt 885721 caaaaatgcc ctgaggcagg tatgataaga agggaattgg gtatcgggag tgatgagcgt 885781 gaaagctctt ttttttacga gaatgttcac cttgatggtg agctgtttaa tgtatctgtc 885841 cattgtgaaa gaggataact ggtttggata tgtatttata gcagcaggtg ctgccatgta 885901 tgcagccaat catgttttgc tgacaaaaga gacaaatgcc atctggttct gcctgattga 885961 tattgcaatc ggcttttcgt tcggatttat ctttcccggc acaggtttgt tcattattat 886021 gctttgtccg gttgcggtcg ccttttttct gcgggggttt cctaaaagaa cagcatggtc 886081 tgtcttatgt ctttcctcta ttttattttt gaccgtcctc atccgtacat atgcgatgtt 886141 cggcaatgaa tttgtcattg atcatttgac tagcatgaca ttcgttgtct tctgcggtgt 886201 cgtgggcaaa ttaatccgca agctgttgga tgcgcaggat acggcaaaac agcagtttca 886261 ggaactgacg gagtcccatc tggcgctgtc tgctgcacat caggagctcc atttatatgc 886321 gaagcaggtt gaagagctga ctgccattta cgagcggaac agaatggcgc gtgaaatcca 886381 tgatacagtg gggcataaaa tgacggccct tctcgtccag ctgcagcttt tgcgtgaatg 886441 gcaaaaaaga gacagccaaa aagcggatga gacagtaggt gtctgtgaaa cacttgcccg 886501 tgaagcgctt gatgatgtcc gcttatcagt acgcactctg caaactgaaa acgatccttc 886561 gctaatcgaa tcgctgaaac agctgacaga ggacttttgc aaaaatgcag gagtcacaac 886621 agaatttgcg gtcagcggtg atcctgcaat catcccgctg tctctccatc cgaccctgat 886681 cagaacggtg caggaagcac tgaccaatgc caaacggcac ggcggcgccg cagcctgttc 886741 gatacagctt gcctgcacaa cggacagcat cagccttgtc attaaggatg acggcaaagg 886801 caatcctgag gcagcacttg gttttggtct cttgaatatg aaaaagcggg cagcggagca 886861 tggcggaatg atccgctttg aaagcgaacg ggatcaagga tttactgtaa atgcagaatt 886921 ttcacttgcc aataaaaaat ggagcttcgg gcccgtgcag caaaaggaga gtttatcatg 886981 attaagatca tcattaccga cgatcaggat atcgtcagag aagggctggc atccctgctc 887041 cagctccgag aagagctcga tgtgatcgca acggcgcgaa acggacagga agccttcgaa 887101 aaggcgaaag agctggagcc ggatatcgtg ttaatggaca tccgcatgcc ggtttccaac 887161 ggggtggagg gaacaaaatt aatcacaagc tcgctgccaa gcgtaaaggt tttgatgctg 887221 acaaccttta aggattcagc gctgattgct gaagcgcttg aagagggagc aagcgggtat 887281 ctgctgaagg atatgtctgc agatacgatt gtaaaagcag tgatgactgt tcattctggc 887341 ggaatggtgc ttccgccgga attgactgcc caaatgctga atgaatggaa gcgtgaaaaa 887401 cagctgaaag gaataaatga gatagaaaaa cctaacgagc tgctcgacct gaccgagcgc 887461 gaaatcgaag ttctggctga gctgggatac gggctgaata acaaagaaat tgccgaaaag 887521 ctttacatta cagaaggcac agtcaaaaac cacgtttcaa atattatcag caagctggct 887581 gtcagggaca gaacccaagc cgccatttac tcggtcagat atggtgtatc tgtcttttga 887641 catatgacgt tttgcatata cgcttctctg aaaaggcctt ttacaggcct ttttttcatg 887701 ccctatgttc tatctgccgc tacatgccgc acgcctttct ttcttctaca atggcaatgg 887761 atcaaaaaaa ggagtgagac gacgtgctgc aagcagaaaa catcaaaaag gcatacggaa 887821 aaaaaacaat cgtgaaaggc atttcttttt ccctcaaaaa gggggagtcg ttcggtctgc 887881 tcgggcctaa cggtgcgggg aaatccacaa ccatctcgat gatttccggc cttgtgccgc 887941 atgacagcgg gaacatcacg gtgggcggct atgttatcgg aaaagaaacg gccaaagcga 888001 aacaaaaaat cggcattgtt ccgcaggaaa ttgcattata tccgacgctg acggctcatg 888061 agaatcttat gttttggggg aaaatgtacg gacttacgca cggtgaggcc aaaaaaagag 888121 cggctgaggt ccttgaatat gtcggtctga ctgagcgggc taaagataag attgaaacat 888181 tttccggggg gatgaaacga agaatcaaca tcggtgcggc tttaatgcat aagcccgagc 888241 tgctgattat ggatgaaccg actgtcggta ttgaccctca atcgagaaat cacattttag 888301 aaacggtcaa acagctcaac gaaacgggca tgacggtgat ctatacgagt cattacatgg 888361 aagaagttga gtttttatgc gaccggatcg ggataattga tcagggggaa atgattgcga 888421 ttggcacaaa aactgatttg tgcagccgcc ttgggggcga taccatcatt cagctcacgg 888481 tcagcgggat caatgaagcg tttcttgtgg cgatccgatc tctggcccat gtgaatgatg 888541 taacagtaca tgaattagag ctcaaaattg acatttctgc ggctcatcat gagaaagtcg 888601 tcacaagcct gcttgctgaa gccactgctc atcatataaa cctgctgtct cttcaggtgc 888661 aggaaccgaa tctggagcgc ctgtttctga atctgaccgg ccgcacgttg cgggattgag 888721 gagggacggc aatgaaaaaa agcatatgga tcgcatggaa agatgtgaaa atcagaatca 888781 cggacagaaa agggtttatg atgcttatcc taatgccgct catcctaacc tgtattttag 888841 gcgcagcgct cggatcagtt gttgacggag gcagccggat tgatgatatc aaagtcggct 888901 acattcaatc agaccagtca gatacagcaa acatgtttac aaaagatgtt ctcaaaaaaa 888961 tgaagtcgat aaaggtcaca aaagtcggca gcaaagacaa gatgaaaaaa ctgattgatg 889021 aaaagaaaat cgatgtaggc atcgttatcc cgaaccattg ggaagccggc aaaacctcag 889081 ctgttgttaa tgccgctcct gatcaaacat tgaaaagttc catcattgaa acagctgcaa 889141 gctcatttat agagcaatat aaagcggtaa aggaagccgc gtcaggctca atggactaca 889201 tcagtaaaac ggaagctgta aagcaaggaa aacttgaccc tgcacagttt gcagaaaagc 889261 tggcaaagac gctagaaaaa gaaacaggtg acaagcttac tattgcggaa aaatctgtcg 889321 gcagcaaagc cgttaccagt tttcaatact attcggcggc aatgctttgc atgtttatgc 889381 tgtttcatat cacagtcggg gcgaaatcat ttttacagga aaaggatacg gagacgcttg 889441 ccagaatgct gatgacgcct gcgcaaaaat ccgtcattct cttcggaaaa tggcttggga 889501 cgtatctgtt tgccatcata caatttttca tatttctgat cgtcacaatc aacgtatttg 889561 gtgtggactg gggcggtaat ctgctgttag tgagtgtact cgggctttct tacgccgcag 889621 ctgtatctgg tatttcaatg ctgcttgcgt cgtgcatcag cgatatgaaa actgcagatg 889681 cgataggcgg cttcggcatt caattgcttg cggttctcgg cgggtccatg ctgccgctgt 889741 accaatttcc ggacgtcttg cagtctgtat ccaaagcggt gccaaatcgc tgggcgcttg 889801 acggctttct ttctttaatg gaagggggag gctgggctga ccttcaaaag cctgtgcttc 889861 tttttgcggc gatcggcttt tgttcacttg taattggtat cagacggctt catacaagat 889921 aaggaggtac aaaaggtgaa aaaaattcta gccatttgcg gcattgagct ttctctcatt 889981 tttaagaagc cacagaacta tttgatcatg tttgctgccc cgcttttgct tacctttgta 890041 tttgggagta tgctcagcgg caatgatgat aaggtgcggc ttgcaatcgt tgatcaggac 890101 gatacgattc tctcacagca ttatattcgg cagctgaagg cacacgatga tatgtatgta 890161 ttcgaaaaca tgtctgaaag caaagcgtca gaaaagctga aacaaaagaa aattgccggg 890221 atcatcgtca tttcccgctc gttccagaca cagctggaaa aaggcaaaca tcctgagctg 890281 attttccgtc acggccctga gctgtcggaa gcgccgatgg tcaaacaata tgcagaaagc 890341 gcattggcaa cgctcaatat tcaggtgacc gcggcaaaaa cggcatctca gacagcggga 890401 gagaactgga aggcggcgta taaaacggtt ttcgccaaaa aacatgaaga tatagttccg 890461 gctgtaacac gacagacgct cagtgataaa aaagagggtg cggaagcaag tgacacagcc 890521 tccagagcag cagggttttc catcctgttt gtcatgctga ccatgatggg agcggctgga 890581 accattttag aagcaagaaa aaacggcgta tggtccagat tgcttacagc ctctgtcagc 890641 cgagccgaaa tcggtgctgg gtatgtgctg tccttctttg tcattggctg gattcaattt 890701 ggaatattgc ttctttccac ccattggctg tttggcatca actgggggaa tccggctgca 890761 gttattgtat tagtgtcact ttttctattg accgttgtcg gcattggatt gatgattgcg 890821 gccaacgtca gaacgccaga acagcagctt gcgttcggca acttgtttgt catcgcaaca 890881 tgtatggtga gcgggatgta ttggccgatc gacattgaac cgaaatttat gcaatccatc 890941 gctgaatttc ttccgcaaaa gtgggcgatg agcgggttga cagagattat cgctaacggt 891001 gcccgcgtca cagatattct cggaatctgc ggcattttgc ttgcatttgc tgcgatcact 891061 ttcgcagcgg ggctgaaagc gctccgagcc taaaaaacat ctgccgttta ggcagatgtt 891121 tttttgcatg tgggtacatt cgtatgggtg cagcctgaac tgcggttaat ccttatctat 891181 catagctaaa attgattcca gccaagaaac gtaatttttc tcccgctcca gcgctttcgt 891241 tagcacaaga tagtggccga agtccggtga agaaaatgac atcggctctg ctgaagccat 891301 aagcttttca tagcttccct gtaagtcaga aagcttggcc tggcgttttt gcagctggtc 891361 tttgaacaaa tcagaagcct cctggcgcga tagacaagaa atgaaataag ccttcagcat 891421 aaattcatcc ttcaccgtct cgggtatcgg ctggtggcgg atcagccagt catgcagctc 891481 ctgctttccg ctgtctgtca gggtgtacat ctttttctcc agctttgtgc cctgaatcgt 891541 tgtccggaac gtgataaatc cttcatccgt cagctttttg agctcagggt aaatctggct 891601 gtgcttggcg ctccaaaact ggccgagctc ctctttaaaa taactcgtaa tatcgtatcc 891661 actcaattcg ccttttcgca aaagccctaa tatggcgtat tttaatactc tcatgctatc 891721 ctccgtgtct ggctgtttcg caaaacagat gagccggtgc tcaactgtga ttctaactgc 891781 ctattcccct tattatagaa aagggaggaa gggaacacaa ccgggctctt tggaaatgaa 891841 gataaaaggt ttgtcagaag gtatccgatt tatctccgtc aatataaaag agatttaaat 891901 ttaattttca gaaaaaatag taacgatatt gattttttat atataatagg aaattggtgg 891961 tatgaaaatt ttttggggga ataaacgtga aaaaagtact tatggcattc attatttgtt 892021 tatcgctgat tctatctgtt ttagccgctc cgccgtctgg cgcaaaagct gagtcagtac 892081 ataatcctgt cgttcttgtt catggaataa gtggtgcatc atacaacttt ttcgctatta 892141 aaaactactt aatttctcaa ggctggcaaa gcaacaaact gtacgcaatt gatttttatg 892201 ataaaacagg aaacaaccta aataacggcc cgcagcttgc ttcatatgtt gaccgtgttt 892261 taaaagagac tggggcaaaa aaagtagata ttgtggctca tagtatggga ggcgccaata 892321 cgctgtacta tattaaatat ttaggcgggg gcaataagat tcaaaatgtc gtaacgcttg 892381 gaggggctaa tggtttagtg tcatcaaccg cgctgccggg cacagaccct aatcaaaaga 892441 tcctctatac atctatttac agtctcaatg atcaaattgt catcaatagc ttgtctcggt 892501 tacaaggagc gcgaaacatc cagctttatg gcatcggtca tattggcttg ctttctaata 892561 gccaagtgaa cggctatatc aaagaagggc tgaatggcgg aggcctcaat acaaattaat 892621 atcttcaaaa aacaacctgc tgtctccgtt acagtgggtt ttttcgtctg agaaagccat 892681 agggtcttat gaccttagtc tatcatgcat acgtcaattt atgacatcag gcactttttc 892741 aaatagagcg gacatgttaa ggtacaacca tcgatttcta tcaatttgaa ataaaaggag 892801 cgctgttatg caaattaaag aaatttttat gatccgctgc atttcgtgct taagtgtcgt 892861 cttgctccat atcatttcaa tggtcctgat gcttcaggca gaagctcttg cagatatttc 892921 tcacactgtt gattctttcc gcacactcct gatgttcagc acgcccgctt ttattttcat 892981 ctctgaattt ttactggccc gttcttatcc tgatggggtg cctgacggtt ttttaaagaa 893041 gcggggaaaa gtgatttttg ttcctttttt atttatcgca gccatcgatg cgctgctgat 893101 gaccagtgcg atggggggag aggtaacctt tctcgcgttt gtgcaaaaat atctggcgaa 893161 cgtattctta ggaaacttta tcggatactt cattctcgtc atctttcaat tttacatgct 893221 gcatatgatg tttcatgagt atttgaaaaa agcatcgccg aaatgggtgc tgtctatctc 893281 atttgtggtg acagccgctt atttaggcta tttctccgca gccagcccgg ctcctgcttc 893341 tgaagaggga ggggcatttc cgttcttctg ggttccgttc gcaggctggc ttttctactt 893401 ttgtctagcc tactattgcg gaaaagaata caagcgtttt ttagcgctgc tgaaccaata 893461 ccgctgggtg gtgtacggcg ccgcaattgc ttctggggcg ctggttgtca ctgtttctta 893521 tgtcggtgaa atcggcatga tcagctcgaa gcggcctgat atcatgctgt attcaacaag 893581 catgattttc ctgtgttttc atttgttttc caaaatgaag catgtgccga aaatcatgat 893641 gtttatcagc aactattcct tttcgattta tctgcttcat gcctatttta tgattatagg 893701 ctacgtgttg cttttgaata tgcccgaaat tcctgccgta ccggctgttc tcctgttgtt 893761 tgccgtgtgc acagccggcc cgattatgac ctcatgggcg ctgaataagt tcaaatacgg 893821 gtatttattt gtggggaaaa tttatcagcc aaaacagaag aaggtaacag tcgaagtgcg 893881 tgatcacgca gggtgaaaaa caagcggcag gagggctcct gccgcgtttc tttacttctc 893941 atccgcttgc agaactgttt ttaaatatag ttttgcagac tcagcaagtc cagatacatc 894001 agccttttct tcatcgaaat acagggcgtt ttgaatgatg ccgtcattca tattgaggaa 894061 aaacttggcg atagtcgcaa gaggctgaac cggctgaaac tctccctgat cgatcccttt 894121 ttgcaatagc cttgaaaacc tttccacaaa aagatcatac cttttctcca aatactgccg 894181 ccgttcttca ttgcgccaag ctgtcactaa atattcaaat tgcaccggcg ccagcgtatc 894241 tgctacatct cgcaggccct cagtcagttc atccaaatag ctggaaatgg aggcccaaac 894301 actttggtgt tcagctgatt tatcaagctt tcggagtcct tcatccagcc ctgtttcaat 894361 aatgcggcga aacatctcct cagtgcttga aaaataaaga tagacaccgc cccggctgaa 894421 acctgactct tctacaacat ccttcatcgt cgttaattcg aatccttttc gtttaaaaac 894481 cgttttggca gcctctaaaa tctctgcctg ccgtttatcc ttgtgctcct ttgttacttt 894541 tggtgacaag atatcgcctg ctttctgcaa ttttcttacc tataagtgta atcaacccaa 894601 tcatgatcag caagcagcca cagacaagaa aagcaagtga tacaccgatc cattccgcca 894661 gcacgccccc gcccgccatg ccgaggatag aggcgagggt tgtcgcactc tgaatagcgc 894721 cgaacaccct accgctgtaa tcgacaggca ctgttgtttg cacgagaatc tgaaatggaa 894781 tatggacgag gccgaaagcc gcccccatga tgaaaaaagc aaatataaag agagtgatgc 894841 cggcaattcc cataccgctt aggaatggcg cacctccagt tgctagtcca agaagaaggg 894901 ttccagctga gaaataaagc aaataagaag tgattcgccg tctgccggta atggccgctg 894961 taaggagcat cccggctccg cttacggcca tgcaccagcc tgccagctcg ggcggagctc 895021 ctgaaaagga gcggataaga ataatcgctt gggaatcacc aatctgcaaa acaaagagaa 895081 cgacacaagc tgttagtaag cctgttaata gaagcggcat ccgtttcaaa aactgaaggc 895141 cttccttgat agaagtaagt gctgctgttt tttcttgagg tgtattggct ttttgtaaaa 895201 aagcatctct gggaaggaaa aacaaaatga cagcggaaag aaagaaggcg ccggcgttta 895261 tataaaaaac agagtgtatc gagaaagcag cgatcagcgt gccgccaagg gcagggccga 895321 agatttttga gctgttatca atgatgctgc tgacggaaac ggcctgctga atgtgtgctt 895381 ccggagccaa ttccttaagc tttccgtttt tagcaggtaa aaaaagtgaa gaaaaacagc 895441 tctgaacgga tagcaatacg taaagctgcc aaagctcact gacataaacg cagctgataa 895501 cagtgagggc acggccgatt tcagatagaa acatgatcgt ttttctgtca aaacggtcgg 895561 caagcagacc cgatacaggt ccgagtacaa tgacaggcaa agcaaacgac atcattaaaa 895621 gcgacatatc taatggagaa gcatgaagct gaaaagcggc taatgttagc acggccaaaa 895681 tgtgaagcca gtctccaagt gaagaaatgg tttgcgaggc taacagtgtc atcagtcctt 895741 tttgattgcg aaacaacggt ttttccatga ttcatcctcc tgattattaa aatgacacta 895801 gtgtcgtttt taattgtatg ggaaaaagac acaatataca atctttttct tgtaaaataa 895861 aggagaagat tgaatagaag ggagaacatt catgacatca gtcaatctaa gctacccaat 895921 aggagaatac aagccgaggg aatccatatc gaaggagcaa aaagataaat ggattcaagt 895981 acttgaagaa gtgccggcaa aattgaagca agctgtagag gtcatgacgg acagccagct 896041 tgacacaccg taccgggacg gtggatggac cgttcggcaa gttgttcatc atctggctga 896101 cagtcatatg aacagctata ttcgttttaa attgagcttg acggaagaga caccggctat 896161 ccgtccgtat gatgaaaaag catggtcgga gctaaaagac tcgaaaacgg cagatccgag 896221 cggctcactc gcgcttttgc aggagcttca cggaagatgg acggctctgc tccgcaccct 896281 gacggatcag caatttaagc gcggatttta tcaccctgat acaaaggaga tcattaccct 896341 ggagaacgcg ctcggcctgt atgtctggca ctcacatcac catatcgctc atattacgga 896401 gctttccaga cggatggggt ggtcttaacg cttttgccgg cggaaagccg gaatactgat 896461 agcagcaatc accagaagtg agaccacagc agccgctgca tataaatgat catagccgct 896521 ggcgacactc gcatgaatgg cgtcgcttat cgcggttttg acttcaggaa cgggaatgcg 896581 ttcgatttgt tcttgtaaag aagaaacttc agaactgtcg atctccggaa tcatctgcat 896641 cgccttttct gaatatccgc tgtccgataa gcggctgttg atctcatcac ctatttggtc 896701 aaacccggct gtgataaaac ctgcataaag agtaggcgcc aaggtcagtc caatttgcct 896761 tactaatgaa agcgtgccaa gagctgtacc cttatttgtt tttgccgctt ctgatacaag 896821 gacgttcagc ggagcgccta acagaaagcc aaaaccgatc ccagctgcca cacttgcgat 896881 cacaaactcc catttttccg tgacccagag cggaaataaa gcaaaccccg cacatgagat 896941 gattcccgaa agaataacgg tttttacagg accttttttg tcggtaagtg ctccgccaag 897001 ccaagcgccg attccggaag ccaacgcaag cggtgtcatc caatagcctg cttttgcggc 897061 agggacaccc aaatactgtt cgacatatga cgggataaaa atgactgccg ccaagagccc 897121 cccggataac aaaccgatga taagcgtgcg ctgaaacata tggtttcgca gcagagaata 897181 cgccaaaatg ggatcgcctc ctcgcatttc aactctcttt tcatacgaga taagcgctgc 897241 aaaacagagt atgccaaaaa taatacatcc ataaacctcc ggattcccca agctgtgtaa 897301 gagatttgcc ccgtcaagat tggtcatgcc gtacatcaca gctaaaatcg acagggacaa 897361 aaggaagatt ccggccgcat cgaggcgctt agcctcaggt gcttttgttt ccgcgataaa 897421 acatgcgccg aaaacaacca atagcacggc aatcggcaaa ttaatcaaaa atagccaatg 897481 ccaagacccg gtccaatcaa gcagaaagct tccgatattt ggcccgagca cagcggccat 897541 cccgttcatt gcgccaagca gcccaagcgc cttcccctgt ttttcctttg gaagggtcgc 897601 gagaatgtga gagctgccga tgatgaaaat cccgccgcct ccaagcgcct gaatcagccg 897661 cgatatcaga aagagcggga agctttggct caaagcaaca agcaaagaac caagtccgaa 897721 caggcaaacc tcaatgagaa agagtttttt tctgccgtag cggtcggaaa gttttccgac 897781 gattggcaca ctgacgctaa gaccgagcgt ataaagggta atgccccatg atccccagga 897841 aggggaaacg gaaaacgact cgtttatcgt tgttaaagca gccgaaataa ttccgttatc 897901 taaagcagcc ataaacacgc caatcgtaaa caggctgatt gcccactttt ggcttttctg 897961 ctctgttaat gcttcagaca ttttcgtcaa ctccttttag ttcacttgaa atatattatt 898021 cattttaaat gaactaaatg tcaaataaaa aaagcctgct cccgcagttt gcggatgaca 898081 gacttactga tttattcttt tttcgcattc tctaatgctc ttgaaaggat agacagccct 898141 tcgtaaacag cctgcttttc ttcaggggac agcagctcta atgaacgctt caatttcagg 898201 tggccctttt catacaaacc ccggaaaatc tttttcgcat tctctgtcaa ctgaacaact 898261 acagagcggc ggtcctcttc agaatgtgag cgtttgacaa atcctgattt ttcaagccgg 898321 tcaagcagcc cagttgtatt ggacagggaa gcccccattt tttcagcaat gtcgctcact 898381 ttcaatgttc catggttgtt taatagcatc agcaccttca tttgcggcat gctcatatcc 898441 agtttcatcc actcggacac atcaccgagc ccggcggacg ttaagacttt catatagagc 898501 acccatattt cccgttcctc cgatgaaaga atgttttcgt ttaagactgt tgtatcgtgt 898561 aaattatatt ccatttcatc acttcctcat cattcactcc tcttaccata ttactcgatt 898621 ttcactcctg aaagaaagtg agcagaaacc gcatgcggga ctttgtccga aaaataacgg 898681 tagtgtataa tgagttggag attattgggg gagaggatcg aactagaata tgattggaga 898741 gaccattgct gattaaaaag aatgctttat caatattaaa aatcgttttt cctattgctg 898801 ttttgctatt tgttatttat caatcgaaaa aagaactgac aaatctgtca ttcaaacgta 898861 cgctcatggt catcaacgga ctggaacgaa cggatttatt catgcttgtg ttgatcggct 898921 tgctggctgt tgcggctatg tcgctgtatg attacgtcct gaagtactca ctgcgcctat 898981 cgatcacaaa cggaaaagtt ttcagggttt cctggatcgc caattcattt aataatgtgt 899041 tgggattcgg cggtttagcc ggagtcgggt taagaatgat gttctataag gagcatacga 899101 aagaccataa ggcactcgtg aaaggaatcg cctggctcac atcatctatg ctgctcggat 899161 tatctgtttt cagcattttc gttgctgcga gagtgctgcc agttgatgaa gtgattcatg 899221 agaagccttg gctgtgggcg gtcgttatcg gttttgcact gatattgccg ttatctttag 899281 cggtgtccaa aataaaagac cgcaaagctg gggacgaaga gaatgcggat aaagtgaaaa 899341 atccgatttt cgcatatatt ggagcttcag ttgttgaatg gctcatggcc gggaccgtca 899401 tctattttgc tttgttcgct atgggcattc atgcagatat caggtatgtg ttcggggtgt 899461 tcgtcattgc ggcgatcgga ggaatgatca gcctcgtgcc gggcggcttc ggctcgtttg 899521 accttttatt tttgctgggg atggagcagc ttggctatca tcaagaggcc atcgttactt 899581 ctattgtgtt gtacaggctc gcctactcat ttatcccatt tatcttggga ctgttctttg 899641 ccgccggcga cctgacggaa aatacaatga agcggctcga aacgaacccg cgcatcgcac 899701 cggcaattga gacgacaaac gttctgcttg ttgttcagcg tgcggtatta gtgagaattt 899761 tgcaaggctc gctttccctt attgtgttcg tagcaggtct gattgtcttg gcctcagttt 899821 ccttgccgat tgacaggctg acggttatac cgcacattcc gcgcccggcg cttttgctgt 899881 tcaacggcct gtccttaagc tcagcgctca ttctgctcat tttgccgatc gagctttata 899941 aacggacaaa acgttcctac acgatggcca ttacagcgct tgtcggcggc tttgtgttca 900001 gctttttaaa agggcttaac atcagcgcga tattcgtact gccgatgatt atcgtattgc 900061 ttgtgctatt gaaaaaacaa tttgtccgcg aacaggcatc ctatacactg ggacaattga 900121 tattcgctgt ggcgctgttt actgtggcgc tctttaacta caatctgatc gcgggcttta 900181 tttgggaccg gatgaagaag gtgctgcgtc acgaatattt cgtccacagc acctcgcata 900241 ttacacatgc aaccatcatg gcgatcatca ttgtgccgct gttcttcttg atatttacag 900301 tggtctatca taagagaacg aaaccgatcg gagagaaagc tgaccctgag cgtcttgctg 900361 cgtttctcaa tgaaaaaggc ggcaacgcgc tgagccatct tggttttctt ggagataagc 900421 ggttttattt ttctagcgat ggaaatgcac tgcttctgtt tgggaaaatc gccagaaggc 900481 tggtcgtgct cggcgatcca tctggccaaa gagaatcatt cccgctcgtg ctggaagaat 900541 ttctgaacga agcgcatcag aagggattca gtgttttgtt ctatcaaatt gaacgagagg 900601 acatggcgct gtatcacgat tttggctaca acttctttaa attgggtgag gaagcatatg 900661 tagatttaaa tacatttacc ttgactggga agaaaaaagc cggccttcgg gcaatcaata 900721 accgctttga gcgggaggag tatactttcc atgtggatca tcccccattt tctgatgcgt 900781 ttttggagga gctgaagcaa atctcagacg aatggctcgg ctcgaaaaaa gagaagggat 900841 tctcgctcgg attttttgat ccttcctatt tacagaaagc gccgatcgcc tatatgaaaa 900901 atgcagaagg agagatcgtt gcattcgcaa atgtcatgcc gatgtaccag gaaggagaga 900961 tatcggtcga tctgatgcgc tatcgcggcg acgctccaaa tggcattatg gacgcattgt 901021 ttatccgtat gtttttatgg gcaaaggaag agggctgtac gtcatttaat atggggatgg 901081 cacccttggc caatgtcggc actgccttta catccttctg gtccgaaagg tttgccgctg 901141 tcatttttaa taatgtcaga tacatgtaca gtttcagcgg cctaagagcc tttaaagaaa 901201 aatataaacc ggagtggcga gggaaatact tagcgtatcg gaaaaacaga tctctttctg 901261 tcaccatgtt cctcgttaca cgtctgattg gcaaaagcaa aaaagactcc gtctaataag 901321 acggagtctt tttttatttc gtttttaaga agtaggtttc aatatcatca agcaggtagt 901381 ttgcggcttt aattccgcct gcggttgtcc atacgacgtc atcgacttca tgtgcattac 901441 ctgacttcac ggccttcagg tttttccata gtgaactgct tgtccactga ttggcccatt 901501 tttcattttc ttttgcatta tcggctttat aagtgaaata aaacagcaca tcagcatcca 901561 tatcaggaat agattcttta ctgtcggttg agaacgtaaa ttggtccttt tgtttcttaa 901621 acagttccac ttgtttttca gggcgtttga agccaagctg gtctaaaata atcccaggaa 901681 atgaatcggt ataatagatt cttgattcac cggataaaaa gcgtacgact gaaacggttt 901741 tgtttgtctg gtcgcccagc ttgtttttta aatcagaaac acgtttatca aaatcggcaa 901801 tgacttcctt gcctttgtcc gccttattca ccgcgttggc gtatagagtc aggttatcct 901861 tccagttccc ggccaaagat tcagcaaaaa cagtcggcgc aatcgcattt aactgatcat 901921 aaattttttc ctggcgcact ttgtttccaa taatcaaatc aggctttaat tctgcgatgg 901981 cttccacatt cggttccgtt tcaagaccga cgtttttaac acctttcatg tcatctttca 902041 gatagtcata ccacgggtcg cccttccatg actttacggc tccgaccggc ttaatgccaa 902101 gcgctaagag cgcctctgtt ccttcattag ttaaaacaac aatccgtttt ggattggcgg 902161 ggatgttgtc tgatgtcccc attgcatgtt tgaccgttct tgttttgctg cttgacacct 902221 cgctgttgct tgaactttct gaactattac aggcagaaag taccataacg gccattaaaa 902281 atacgaatag catgctgata tgctttttca tctttttcct cccaatattg aaattcatta 902341 tcatttagat cataataagc agtgttaaga gtgtcaatcc ctaattgagg attattctca 902401 aaaacaaaca ttacatagta aataactagg agaattagat catgatctgc aaaaaggcat 902461 cttcaaaatg gattgtgtta gtatgtctga ttttcatttt actgacggct gtctgcgcaa 902521 gcgtcgtgta tggctataca ggtacgtcat ggagacaggt ctatcaggcg tttacttcct 902581 tcaatggaac aaatgagcat gtcatcatca aggatgtcag gcttccgcgc gctttggttg 902641 cgacagtcgt cggcgcctcg cttgcagccg cgggcgctct catgcaggcg ctcacaaaaa 902701 atccgcttgc gtcaccgggg attttcggga ttaacgccgg tgcaggtttt tttattgttg 902761 ccggatcgtt ttttctgcat attcagtcac ctcaggcatt agtatggagc tcgtttctgg 902821 gggcagcatt taccgctgcg atcgtctatg cagcaggctc gcttgggagg gaagggctga 902881 cgccaatcaa actgacgctg gcgggagctg ccatggcagc catgttttct tctctgacac 902941 agggcttgct gtctgtcaac gaactcgagc ttgcccaggt gcttttttgg ctgactggct 903001 ctgtgcaggg ccggagtctg gatctgttga tgacgatgtt tccatatgca gcggcagcgc 903061 tggtaatctg cttctttctc ggccaaaaaa ttaatctcct cgttatggga gaagatgtgg 903121 caaaaggact cggccaaaaa acaggcctgc tgaaatttgt gatggcgctt tgtgttgtca 903181 tgcttgcagg gtccgctgtc gccattgccg ggccgatttc ttttatcggc atcattattc 903241 cgcattttgc ccgctttgtc gttggtaatg attatcgctg ggttctgcca ttttccgctg 903301 ttttgggtgc cattttgctt gtttgcgcgg atatcggtgc gcgatatatc attatgcctc 903361 aggaagttcc tgtcggggtc atgaccgcca tcatcggaat gcctgtgttt gtgtacatcg 903421 caagaagggg ggcgaagcta tgaaacttcg ttttggcgtt actgcggctg aaaagaaagc 903481 atggatcgtc tttttggttt tactggggtt aacagctgct gtactcatca taagcgctgg 903541 tctcggacaa aggtttattc ctccctggga tgtagcaaaa acattctttg gtgcaggttc 903601 caagctggat gaactgatga tcatgtcgtt ccgcatgcca agaattttga cggctttatg 903661 cgccggtgtc tgcttggcag cggcaggcgc gatattgcag gggctcgtca gaaaccctct 903721 cgcatctccg gatattatcg gaataacagg aggagcggcg gtagcggtcg tgcttttaat 903781 gatgttcttc tcagaccgca gcagttcact tacgatcagt ctgtcatggc ttccagcagc 903841 cgcatttatc ggcgcatcgg ctgtcgggct catcgtctat ttactggcat acaaaaatgg 903901 cgcctccaca tttcggctgg tgcttatcgg aatcggattt tcaatgtcgg cgcaggcgat 903961 gactaccctg ttgatgatca aaggcccgat ttaccgagca tcacaagcca atgtgtatat 904021 cactgggtca gtttatgggt caaactggca gcatgtaaaa atagctatta tcttatctgt 904081 cattctctta ttcatttgtt ttgtcgcgct aaaaaatatg aatatacagg tgctgggtga 904141 agatattgcg gcgggtgcag gaagcgctgt gcagcgaaat cgttttttct tgctcctttt 904201 gagtacggct cttactggtt gtgcagtttc agttgccggc acaatcggtt ttgtcgggct 904261 gatggcgccc catattgcaa gacggcttgt cggctcatct tatggcgcgc tgctcccagc 904321 gtcggcactt attggagctc tgctcgtttt aacagctgat atcgtcggca gaaccttatt 904381 tgctccggtg gaagtgccgg ccggcgtctt tacagcggct atcggcgcac cttattttat 904441 ttatttgctc tataaaacaa gaaattctta atcgttacac ccattttctt aaaaaagaaa 904501 atgggttttt ttgataatga ctgaagattc gtaattattt ttgctatact gacagagaca 904561 ttgataaaga aagggcggca gatgaatgaa agaagcagag gtattaaaat atgaagcatt 904621 tacaagcagt cccggcaaag gaaaccccgc aggcgtcgtt ttgcagggag acgattatac 904681 ggaagacgag atgcagatca tagctgaacg tgccgggtat tcagaaacct cctttatccg 904741 aaaaagcgag tcggccgatc ttgaactccg ttactttacc cctggacacg aaatgaattt 904801 gtgcggtcat gcgacagttg cttctcttta cgcattatgt gagaaaggaa tgctggagag 904861 cggtaaaacg tacagcatcc aaacgaaagc gggtatcctg cctgtgaaga tttctgaaaa 904921 agatggccgc attcatatca cgcttgaaca ggcctctccg caattcaaac catttacagg 904981 cgatcggaaa aaacttgcgg acgcactggg tatcaccgat gaagattttc atgaagacct 905041 tccgattgtg tttggcagca ctgggatatg gacagccatc gttccgctta aatcattgga 905101 ggcttccaaa aaaatggtgc cagataacaa acaatttccg gaagtgttag ttgatctgcc 905161 aaaagcttca gtccatccgt ttacctttga aaccgtccat cccgacagcg acctgcacgg 905221 gcgccacttt tcatccccgt attcgggaac gattgaagac cccgtgaccg gcacagcatc 905281 cggcgtgatg ggggcttata tgaaacatta tggcaatgcc gagcagcata aatttatcat 905341 tgaacaaggg caggaaattg gaaaagacgg aaaagtggag atcgaaatga acgaagccgg 905401 cggccatgtg aaagtgaaca tgacaggaac agccgtttac tcagaaaccc gtattcttaa 905461 aatctaatac ggatgatggt ttacaaaaag atgcactttc cgttatcatt atgaaatgat 905521 aatcattttc aattgcatag gaaggtgaga cggtatgcct caaaccgaac aaatacatca 905581 gcattcagta ctgagggaca tcatacgcag cagaagatcg attcgaaagt ttaaacaaga 905641 gccagtacct tcagcagtca ttcttgacat gcttgaaacg gcaaaatatg cgccaaatca 905701 cagagtgaca gagccatgga gatttattta cgtttccagt gagacaggta aagcgaacct 905761 cattaataca tttgcagcgt tctctaagaa atccaagccg gatatgacag aggaaaagct 905821 tcaaaatttc aaaaacacac ttgggcgcgt tccgggattt ctcctcgtcg tgtttcagga 905881 agatgaaaac gaaagagcgc gggacgacga ttttgcggca acaagctcgt tgattcaaaa 905941 tcttcagctt ctcgcttggg aaaaaggaat cggcatggtt tggaaaagcg gaaaaatcct 906001 ttatgacaaa gaagtccatc aggcctttgg tttacaggat aatgagcgtt tcgccgccat 906061 catacaaaca ggttatcctg acgaggcgcc ggaagtgaaa aaacgcacac cgatccgcga 906121 ccgattcact gaaatgtaaa aaaccccttg tctcaaacgg agacaagggg tttttcatta 906181 acgagatttc tttttcgctc tgttgtcggc tgctttcgca cgctcttgcg cttcgcggtc 906241 atctgcatca gcaagctcgg ttgaatattc ttcgtaaacg ccgtcagttt ccctttttaa 906301 ggcatcggga acttgtggaa gcttttgttt gtttttatca cggtttttgt ggatatgatt 906361 tctgcccata tcaaattccc cctaaaaagt gatatcaaac aaatatagta tttggtttta 906421 aggggctatg tattcctact tccgcttagc agctttttcc gcttttttaa attcgcctga 906481 ataaagaact tcctgcattt ttttcaggtt ggcgccttgc tggtgcttct ccctcttttt 906541 ttccataaaa aggacctcct tcaaccatgt tattcttaag gttgacgctt cctgctgttt 906601 ttatacagtc tttcggtccg ctatcagctg tgagagtgca aattcaagat ccgaatatgt 906661 aaaacgaaat ccagaggtta tcgctttttt cggaagagcg cgctgtcctt tcacaatcaa 906721 aagactcatt tcacccaatg cttttgataa aaagaattcc gggacgggga gccagtgcgg 906781 gcggtgcttc acccgtgcaa tcgtttttcc gaattgcttc atgtccacag gattgggcgc 906841 ggtgacattc attgggcctg agatgccggc gttttccacc gcatatcgga tcatctgggc 906901 cgcatcctcg acatgaatcc atgacagcca ctgccttccc gttccgatcg ttccgccggc 906961 cagaaactta taggggagaa tcatgagcgg gagagcgcct ttttctccaa gcatcacgcc 907021 aaatctcgca taaactgtcc ggatgcccat cgcttcaata tgctgtcctt ccttttccca 907081 caggtgtgca gtatggctga gaaaatcctc atctgacgtt gcagaatcct ctgtgaaagt 907141 tttctcaagg cttgtgccgt aaatgcccac ggcactggct tggatcaatg tcttcggctt 907201 ctccttctgt ttctgaataa gccgctgcac ttcacgcgtc gcattgatac ggctggagag 907261 aatgtgctgc ttcgtttttt ctgtccagcg gccaaaaatc gattttcccg caagatttat 907321 ccagacatca atatgaggaa gttcctgctc cggtgcggct ccttccgaca gccattggac 907381 atatgtcata tttttttgtt cagtttccct tgcgtttctt gataaaatat aaacatggtg 907441 tccctggcgg gtaagaacgc ctgtcagatg ctggccgaga aaaccggttc cgcccgtcat 907501 tgcgatattc atgaacatct ctcctcatcg ttctaataaa tatactttac ctcattgtaa 907561 taaaagaaaa cgcgtttcag gcctgagaag ggagattaag atgccgttta ttacaaaaat 907621 atcaacgcaa aaaaagaata cggaacgctt caatattttt ctggatgata aatacgcctt 907681 cagcgtggac gcggatgtgc tcgtgaaatt tgagctcaag aagggaaaag aactcgatga 907741 tcttgacatc attgagattc aatacggcga tgaagtgaag aaaggcttca accgtgcgct 907801 tgacttttta tcctatcgaa tgcggtcgac gaaagaggtc gaggatcact taaagaaaaa 907861 agaaacctcg ccccccgtca ttgcggaagt catccatagg cttaacgatt acaagtactt 907921 aaacgaccag gaatttgccg cagcctatgt cagcactcac aaaaaaacaa acggaaaagg 907981 ccctgatgtt ttgttcagag agctaagagc gaagggaatt gatgacgata caattaagga 908041 ggcgctaagt tccttttcct ttgaagatca gacaagagaa gcggtcaagc atgttgaaaa 908101 gcttctcaaa aaagataaaa agctttcgac gaaagaactc aaacagcgcg cccagctgca 908161 gcttcagcgc aagggcttct catttgatgt tatcagcgcg gcgatggatc agattgaata 908221 tgaaaatgat gaagacacag agaaagaagc gctgcgcctt cacgcggaaa aagcgtttag 908281 aaaataccgc tatgacggct catatgaaag cgccatgaag gtcaaacaat ttttattccg 908341 caaaggattc tcactcgatt taatcgagca attactgcag gaagaggagt actgaaatgg 908401 agaaacgata cagtcaaatg acaccgcatg aactcaatac cgaaatcgca ttactttctg 908461 aaaaagcaag aaaagccgaa cagcatggaa tcataaacga actggcagtg ctcgaacgga 908521 aaattacgat ggcaaaagca tatttgctga acccggaaga ttactcaccg ggagaaacat 908581 atcgtgtgga aaacactgag gacgagttta ccatcagtta tttaaatggc gttttcgcat 908641 ggggatacag gacctcttcc cctcagcaag aggaagcgct gccaatctca gtattgcaag 908701 aaaaagaata aagcgtaaca ggaggctgat gatcagcctc tttttgtttg cagcacattt 908761 acacgaattc ttaaagaaaa aatcattgaa ttcacttgaa aaatctttta agatgaaact 908821 cgttgttttt taaaatcaaa ggaggcgatg acgttgagta tcaaaaaccc atctgtaaaa 908881 tttattatat ttgttcttat gatttgtaca ttttcaatcg gctatacaga atacgcggtg 908941 atgggtattt tgacgtcgat tgccaatgac tttcatatac aggtttcatc cgcagggctt 909001 cttgtcacgg cttatgcggc aagcgtttgt ttgacagggc cgctcgtcac catcatttcc 909061 gtcaagcttc cgagaaagcc tgtgcttctt gggctgatgg cgatatttat cctttccaac 909121 ctgatgagcg cactggcgcc gaattttgcg gtattggcca tttcaagaat tttatctgcg 909181 tccattcacg gcgctttctt cgcgattgcc atggtattcg caagtgaaat ggttccgccg 909241 gaaaagcgtg ctgcagctgc tgcttcaatg aacggcggac tgacagtggc tctaatgctt 909301 ggtgttccat tcggctctta tctcggagat gtcctgaatt ggagagcggt gttttccatc 909361 attacggcac ttggtgtcat cggattttta ggccttatgg ctgccgtgcc gaacagaaaa 909421 ccaaaagtga tcccaatgct tatgaatgag tggggtgttt ttaaacacaa acaagtgctg 909481 ttttccttcg cgattaccat tttaggctat tccggtgtct ttatcgccta cacctttatc 909541 gaacccattt tgaggcattc agccggattc agcacggttg gcattacagg tgctctcttt 909601 gcgtatggat tgggaggcgt tgccgggaat ttctttgctg gaaaggtacc gctgcctttg 909661 ctgactcgga cgatgatcgg cgtaatgatc ggtttaatcg gtgttctggc tgtatttcct 909721 tacatcgcca tttacccggc tgcagccatt gtggcaacgt tcctattcgg ggcatgcgca 909781 ttcggcacgc cgcctcttct gcaaacaaag gtcatttcct catctgaggg cggcacaacc 909841 attgccgcag ctgtcagcgt atcagcattt aaccttgcca atgcccttgg tgcatggatc 909901 ggcggaatga ttttaaacgg aacaggctct tattcctggc tgtttgcagg aggtgcgctt 909961 atgaccgcat gcggacttgt gctttctacc ttcgcacact tatcagaaaa gaagagcgtc 910021 tacgaatatc aagtcaataa agggtaaaaa acagctgcag tgtatgcagc tgttcttctt 910081 taccgtttgc ctgaggctct cattctttct tgaggatgct gattgataga tccgtcagca 910141 cgctttgaag catagtcgtc ctttgctctc ggttcaccct gaaatttgtt ttcgttttcg 910201 taaggaaatc ctttttcttt atttcggacc atgtcatatc cccctaggtt cgagatcaaa 910261 aagttgcgtc ttttcagatg aagacgtaag gttagtatat ggagaacacc acgtaataaa 910321 gcgttatttt tttcctgaag aaaggagact gcacacatga atatgtacat tgagaaactg 910381 actaatctgc ttctggaaaa gaacgagatg atcagctata tacaggcaaa aacgtgggtg 910441 gaattgttat ggagcgattt cgaagcaacc tacgcaaaag ccggacacgc ctatcaaggt 910501 gaaaaaatga ctgaaaaaat cgtcacacaa tggattgaaa actatggcgg ccagctccac 910561 ctttttcaaa gctcccgtaa cgacgtgaat gattacttaa atcaaagcag aggccttttg 910621 cattaaaaac ctgccgttaa cgaccggcag gttttttcat tttcttaaaa ttaccttaac 910681 aggaagaaat cataaacaaa acatgtttca ccagcctgtc aatcagggaa taccacttat 910741 atcttgtcaa aatgcgagga ggagctttat atgaaaaaga aacaagtaat gctcgcttta 910801 acagctgccg caggactggg tttgacagca cttcattccg ctcccgcagc aaaagctgcg 910861 ccccttcacg acatatctgt cagcatgcca tcatccgata cttacatcat aaaagcagga 910921 aagctgaatg tccggactga gccaaatcat gaaggtgata ttctcggcac tgtatcatca 910981 gaacaaaagg taaaagtcga taggttcgta aatgccgatt gggctcaaat tcatttcaaa 911041 ggaaagaaag catatatttc aactcacttt ttaatgaaaa ccgcaagcca agcgaaaaca 911101 acgaaacaga cagccttcta tacaccgacg cccgaaaacg gaaaagctaa gcagctctca 911161 tctggaacag aggtgacaat acttgggtgg ggattcagtg aaaacggcgg atttgacttc 911221 acttgggcgt tcgtggatta tggcggagtt aaaggctata ttcacacaaa ggatttacaa 911281 atgcgataaa aaggcaggcc gaggcttgtc tttttgccta tgcatgaaac atttcttctt 911341 tctgcacgta acaatgagaa aggagatgat gatatgacgg gtttagtcgg cggagggctt 911401 atgatcattg cgggcatact gatcaaactg tttcctccca aatcgatcaa cagtgtgtac 911461 ggatacagaa cgagacgctc aatgtcagat caaagattat ggaatgaagc gaaccgttac 911521 agtgcatcat taatgatcct gtcaggcttg gtgattgcgg gaatgggttt gctgctggga 911581 tcaaacttgt ttattcttca gcttatcctg ctgattgccg cctgtgtcat aacatttatg 911641 ctaacggaga aaaggctgaa aatcatgacg cacagtcaag gaggagatag aagtggacgg 911701 agttaaatgc cagtttgtca atacgaacgg aatcacgctt cacgttgcag ccgcaggacg 911761 ggaagatggc ccgttaattg tcctgctcca tggatttcct gagttttggt acggctggaa 911821 aaatcaaatc aaaccgcttg ttgatgcggg ttaccgggtc attgctcctg atcagcgggg 911881 ctacaatctc agtgacaaac cggaaggaat tgattcgtat cggattgata cattaagaga 911941 tgatatcatc gggcttatta cgcaattcac tgatgaaaaa gcaattgtca tcggtcatga 912001 ctggggagga gctgtcgcat ggcatttggc ttccacacgc ccggaatatc ttgaaaaact 912061 gatcgcgatc aatatcccgc acccgcacgt catgaaaacc gtaacgccgc tttatccgcc 912121 gcaatggctg aaaagctcgt atatcgcata cttccagctg cccgatatac cggaggcatc 912181 actaagggaa aatgattatg atacattaga caaagcgatt ggattatccg accgtcccgc 912241 gctttttaca tccgaggatg tcagcaggta caaagaagcg tggaagcagc cgggcgcgct 912301 gacagctatg ctgaactggt acagagccct cagaaaagga agcttggcag agaaaccctc 912361 ttacgaaaca gtaccttacc gaatgatctg gggaatggaa gaccgctttt tgagcagaaa 912421 gcttgcgaaa gagacggaaa ggcattgccc gaatggacat ctcatctttg ttgatgaagc 912481 ttcccattgg attaaccacg aaaagccagc catcgtcaat cagctgattt tggaatatct 912541 taagaaccaa taagctaaaa tttctctcca tccgtctgtc ataatggcag actttttctg 912601 tgcgtttttt ttcatagtct gttttaaaca tgacaaaata acattaaaaa tcatgaatgt 912661 caccataaaa ttgtaacaaa aaacaggttt aaacgacttt aaaaaaagga atagccttac 912721 tgaagatttg tgtaaaactc ccctaaggca atacttaaaa agaataataa aaagaaggtg 912781 ccttaatgaa gcaaggatta atctcgatta ttatcccgtc ttacaatgaa gggtataatg 912841 ttaaactcat tcatgaatct ttaaaaaagg aatttaaaaa cattcattat gactatgaaa 912901 tattcttcat aaacgacgga agtgttgatg acacgcttca gcagatcaaa gacttggcag 912961 cgacgtgcag ccgggtaaaa tatatatctt tttctcgaaa ctttggaaaa gaagccgcaa 913021 ttttggcggg ctttgagcat gttcagggcg aggcggttat tgtcatggat gccgatctgc 913081 agcatccgac atatttgctg aaggaattta tcaaaggcta cgaagaaggg tatgaccaag 913141 tcattgccca aaggaacaga aaaggggaca gctttgtccg ctcactctta tcatctatgt 913201 attacaagtt cattaataaa gcggtggaag tcgatttgcg tgacggtgtc ggtgacttca 913261 gattgttaag ccgccaagct gtgaatgcac ttttgaagct gagcgaagga aaccgcttct 913321 caaaaggcct tttttgctgg attggctttg atcagaaaat tgtattttat gaaaatgtcg 913381 aacgaaaaaa cggcacctcc aaatggtcgt tcagcagtct gtttaactac ggaatggacg 913441 gcgtcgtttc atttaatcat aagccgctga gattatgttt ttatacaggc attttcatcc 913501 tgctgctttc catcatttat atcattgcca cattcgttaa aattctgact aacggtattt 913561 ctgtgcctgg gtatttcacc attatctcag cagtgttatt tctcggcgga gtacagctgt 913621 taagtcttgg aataataggt gaatatatcg gccgaatcta ttatgaaaca aaaaaacgcc 913681 cgcattattt gatcaaagag gcgaatatcc cgaacaaaga cctgcctgaa acgaacgaat 913741 taaaaagcat gcggcgtctg acaaaaatgc actgaaaata ccaagcgcca ttggcagtgc 913801 tttttttgcg tgtctattat cttaaaagca agactggaga attcatatga aaagaaaaca 913861 tatcatgatc tatgcggcca gtttgctggt gtccgttctg gcacacgctt tttttgtgaa 913921 agaatgggcg gaaggcaggt atatgacagg tccgggtgac gggcttgcgc aaatgatcgt 913981 atttaaaaaa ttattatttg accaatatac acacgggaat tttttctaca attattcatt 914041 cggacttggc ggcggcacat tcagtcagct cggctattat ttttctgcgt cttttctttt 914101 tcttgctgtg tctgccgctg tttggctgct tcaagccgtc cagctgatcg gagaaacgga 914161 tacgcttttt tgggcagagt cagctgtttt tatcagtatt ttcaaattga gcttgatcat 914221 ctttacgtcc gcttctgttt ttcattatct tcttaagcac agggcggcat cgttcacggg 914281 agccgtgtta tacggcgtct caattattta tttccgtcac gaagcgtatt gggaattttt 914341 caccgataca atggtttggc ttccgctgct tgtgcttggc gcagaaaaaa ttattagaga 914401 gcggcgtccg gcgtggttta tcgttgcgtg ttcgctgacg ttaatcaaca atttttactt 914461 tgcatacata aaccttatat tcatcggaat ctatgtgctg ttcagatggc tgatccgttt 914521 ggaaccacat gaagagaaaa gatggattca aatcagatta tttctcgttt caggcttcat 914581 ttcttttggc atcagtgcgg cggcgtttgt gccggtagta tacggttttt taaacaacct 914641 gcgccctcca tacagccaga aaatagagtg gctcaatttc gatgataata tcttattttc 914701 gagccggatc atcattgtgc cggccgcttt tctgctgttt ttgtttatta tttcttttta 914761 caaaaaccgt gtgtttcgtc tctttgccgg gttgagcctg ctgtttattc tgtttcattt 914821 cagtccgtat gcggcaagcg tctttaacgg tttttccgcc ccgcaaaacc ggtttgaata 914881 tgttctggcc tttaccattg cgggagcagc tgcggctggt ttgtcacagc tgtctgaatt 914941 gaaacggaaa gaactgctcc cggccgcagc tgtcgtcctg cttctttact tgtatcatat 915001 ccaaaggtat aagctcgata tatggaagcc tgcgaatgaa agtattctat tgctcttact 915061 catgacaatc gcagccttgt ttgctgcagc ttttgcgaaa aaacgggcaa aaatggctgt 915121 gtacggtata atcattcttt cttcgctgtt tgtcgccaac tcctatcaaa aatacgcgct 915181 ctcagaaggc ggcgatttgg acagtgtgac aaaagaatat cttacaagtg aggaatacag 915241 agggcgggaa tcatctgagc tcatcagacg tttacagaag gaagacgatg acccgctcat 915301 gagaatcgac tggatgaacg gggtccgcaa taatacgcca atcatttacg gatttaatgg 915361 cttcagcgcg tattccagca ttttaaacaa agatctgctg gccttctatt ggaatgattt 915421 aagcatcgat atgggcaggg aaagcgtcag ccgttacgcg tcattgggag acagggcgaa 915481 tttatacagc ctgctttacg gcaaatatta tatgaccgaa aaaacaaacg aagccagcgt 915541 cccgtacggc ttcaaaaagc atttagaaac agagcattat gcagtttatg agaatcagta 915601 catgcttcca ttcgttaaaa cagcggatgc catatacagc gaaagtgagc tggaccgatt 915661 gcccgctctt gcgaaagaac aggcgatgct gaaaggaatt atattaaaag atccatcagg 915721 aaaaacggag cagacaccaa aaccgtccaa tttgatcacc aagtcggaca tcaccgcaaa 915781 acaagcccag tatcaaaacg ggctgctaac cgtaactgga gaaaacggag gagagctgat 915841 catcaccccg aaacagccat catccgctcc gggagactac tatgtcagct tttatttgaa 915901 aagcaaagca aaagacaaag gatttacatt aaaggtaaat gattatgtca caacaaggaa 915961 atcgaacaaa tcgatctata aaaccggagt aaataatata acggtaagag tgcctaaatc 916021 aggccatatc tcaatcaatc ttccgaaagg aacctatgag ctgagaaaca tagcgctcta 916081 tgaagaaaat taccaaacgc tgaaaaacgc tgtaatgcaa aataaaacag agaaagcaga 916141 caaactgaat tggaacaaaa atcgactgac cttttcctat catctgtcaa aagaccagta 916201 catcatgctt ccgatcccat atgaaaaagg ctgggagctg aagatcaacg gaaaaacaca 916261 gaagatcgaa aaagcggatt atgcttttat aggcttcaag gcgcaaaagg gagacaatca 916321 cattgagctg acttactatc cgccatactt caaaatatcg gcgatcatat ctctcgtcag 916381 tctgctgctt gctgtttttt atataagacg taaaaagccc ggctctatat agagccgagc 916441 tttaattttt tctgaagttt ttcttcgctg aatatccatc ccgtatagga tgaacgaatc 916501 gtgagatcat ggccgatatg aacaattgcg acaaacggat aatggccttt gctccgataa 916561 cgcaggtcga taaatctcac ctcataatga tctttaaacg tatccacttc ccaccggtat 916621 accggagaaa aggacagaaa cgccgcgatg ttatcatcct gctttgccgc atgcattaca 916681 tcggtttcag gaacaggcac ccgattaaat gtatccagaa tcacgacatg tccttccatg 916741 cttcttccta catagaaagc atgtgctgtc gtcactgcga ttcgccattg cctgaatttc 916801 atcgttggag aaataataat gctttcgatc tcatcatgaa tcatctcatg aagcttccgt 916861 ttaattctca gctgcatgat caggcgcacc aagtagtagc ctaccaatat gatatataag 916921 ctgagaaacg tgatgccggg actcccgcct gcataccaaa tcgcgatagc tgccagatgg 916981 ctgataaaaa taaacggatc aaacgtatta atcagcccga gcgcaaccca ttttttcgaa 917041 aacggacgaa tggcttgtgt tccataggcg ttgaatatat caacaaagac atgcagaacg 917101 actgccagca gtgtccacag ccacaggtgc agaaaatcgg cctgaggata aaataaatac 917161 agaatcgccg ggatgatgac agaccaaaac aaaacggcgg gaattgaatg ggtaaatcct 917221 ctgtgattcc ttatataaac agcattgttt ttaagcttta acacagtatc aatatccgga 917281 gcctgagagc ccgcaagcgt tgcgatcata acagcgtgag ccattgccgg atctgatccg 917341 acaacaggat caagcgtcgc aataccgccc agtgcgatgc ccataacgac atgtgtgccc 917401 gtatccatag gtgacctcct tgcagggtga tcctgcacat tcactttgta agaaattccc 917461 cattttcata tacccaattt ttaaactgat tcaatcgttc tcatatgttt ccgctttttc 917521 tttattacta tttaatgtaa catattatcg tactgtgccc ttagtgtaca acaaaaaaca 917581 gtctaaagaa aagcggggcg cgaaagactg gggagaaaca catatgaacg tacttgaaga 917641 caaattaaaa caaaaagaca tacagcaatt tcgcgatgat ttaatctcat ggtttgaacg 917701 agagcagcgc gttttgccgt ggagagagga ccaagatcca tataaggtgt gggtatctga 917761 agtgatgctg cagcaaacga gagtagagac agtgattcct tactttctcc ggtttgtaga 917821 acaattcccg acagtggaag cgctcgctga tgctgatgaa gaaaaggtgc tgaaagcatg 917881 ggaagggctc ggctattatt cgcgagtcag aaacctgcaa agcgcggtaa aagaagtgaa 917941 acaggaatac ggcggcattg ttcctccaga cgagaaagat tttggcgggt taaaaggcgt 918001 cggcccttat acaaagggag cggtgctcag cattgcctac aataaaccca ttcccgcggt 918061 tgacggaaat gtgatgcgtg tcatgtccag gattctatct atttgggatg atattgccaa 918121 accaaaaaca agaacgatct ttgaagacgc catacgagct tttatttcca aagaaaaacc 918181 atctgaattt aatcagggct tgatggagct tggagccttg atctgtacgc caaaatcacc 918241 ctcatgcctg ctttgcccgg ttcagcagca ttgctcagca tttgaagaag gcactgaacg 918301 ggagcttccg gtaaaaagca aaaagaaaaa gcccgggatc aaaaccatgg ccgcgatcgt 918361 actgactgat gaagacggac aagtgtatat ccacaaacgg ccgtctaaag gtttgctcgc 918421 caacctgtgg gaattcccga atcttgaaac acaaaaaggg atcaaaactg agcgtgaaca 918481 gctcattgct ttcttagaaa acgaatatgg catacaagct gatatcagtg atctgcaagg 918541 tgtagtcgag catgttttca cccacctggt atggaatatt tcagtgtttt tcggtaaagt 918601 aaaacaagtg tcggatacca gcaagctgaa aaaagtaacg aaagaagagc tcgaacaatt 918661 tgcgttcccg gtgtcacatc aaaaaatctg gaagatggca ggagaagcag ccgccatctc 918721 ggctgctccg taaaccattc ttaatcgtaa gagacgcgcg tgccgtggct gtagtccgct 918781 tcattgcgct tcattccgcc gcgcgcttca atttcttgcg ttaattcccg gtattttgat 918841 tggccttctt cgttcaaata aggcataatt tgctgaaagg catgatgaaa ataagcgagt 918901 tcactgttct tccaatcttt tttggaaacc atgttcaatt cgctcatatc acgtccgaca 918961 tacataacag aagaccccct ttaaagttct tgccattatt gtttgtggaa ataaaagaac 919021 tatacgctac aaggagatga ggaaaaatgg aacaaaataa atgtgcactc gtaacaggaa 919081 gcagccgcgg tgtcggaaaa gcggccgcga tcagacttgc tgagaacggc tataacatcg 919141 tcattaacta tgcacgcagc aaaaaagcag cattagaaac agcggaagaa atcgaaaagc 919201 ttggcgttaa agtgcttgtc gtaaaagcaa acgtaggaca gcctgcaaaa atcaaagaaa 919261 tgtttcagca aattgatgaa acgttcggca gacttgatgt ttttgtcaat aatgccgctt 919321 caggagtact aagacctgtc atggaattag aagaaacaca ctgggactgg acgatgaaca 919381 ttaatgcgaa agcattgctt ttctgcgctc aggaagctgc caagctaatg gagaagaacg 919441 gtggcgggca tattgtcagc attagttcat taggctctat ccgctatctt gaaaactaca 919501 ccacggtcgg tgtatcaaaa gcagcgttag aggctttaac ccgttatctt gccgttgagc 919561 tttcaccaaa acaaattatc gtcaatgctg tttcaggcgg agcgatcgac acagatgcgc 919621 tgaagcactt cccgaataga gaagatctgc ttgaggatgc gcgccaaaat acgccggcgg 919681 gacgcatggt cgaaattaaa gacatggttg atactgtgga gtttctagtg tcttccaagg 919741 ctgacatgat ccgcggacag acaattatcg ttgacggcgg acgctcactg ctcgtttaaa 919801 aatttttaaa aaagaggaat agctatacga tcacctgcac attctaatga ccgtggaggt 919861 gataacaatg gctaactcaa ataacttcag caaaacaaac gctcaacaag ttagaaaaca 919921 aaaccaacaa tcagctgctg gtcaaggtca atttggcact gaatttgcta gcgaaacaaa 919981 cgctcagcaa gtcagaaaac aaaaccagca atcagctgga caacaaggtc aattcggcac 920041 tgaattcgct agtgaaactg acgcacagca ggtaagacag caaaaccaat ctgctgaaca 920101 aaacaaacaa caaaacagct aatcactgaa acagaaaaaa gcacttcatc ttcgggtgga 920161 agtgcttttt tctgtttgaa aaacgacaaa acttgtggaa ggtctacaga atgagtcaaa 920221 gggtttgctt tatggagatc gaaatgatta aaggaggaaa tgtttatact ttcatcaggc 920281 tgaaggagga accgatgacc gaatttgaaa agctggtaag tgaacagatg aaaacgatgg 920341 ataagcttct cgatctccaa tcagagctcg accgctgcaa acaaattgag gcggaactcc 920401 ggcatttgga aagggatgca aggctgcgtg ggattcaggc tgaaattgcg gtaaaacgga 920461 aacaccttgc cgatatacag gatatgtttc aaaagcagac agagcaggtc attcgttcat 920521 atcgcagctc agaaaagccg tcttcctttg tgtagtgcag gaatgtgcca ttccccggcc 920581 ggaatggctc ttttattttc atttttcaat ttgtaacgtt ataataggta aaagacgttg 920641 tcggtaagca aatttggaca tactaactgt agggctttat agaaagtagg ggagaaatat 920701 gggctatccc aaggaaggag aaaccattca aattcacagc tataagcaca acgggctgat 920761 tcatagaatt tggaatgaga caacaatctt aaaaagtaca gaaatgtgtg tcatcggagc 920821 caatgaccgg acgatggtaa ccgaatcaga cggccggaca tggataacca gagagcccgc 920881 aatctgttat tttcacgcaa gacaatggtt taatgtcatc gggatgctga gggaagacgg 920941 ggttcattat tattgcaaca tcagttctcc gtttgcctat gatggcgaag caattaaata 921001 tattgattat gacttagatg ttaaggtttt tcctgacatg acctacaata ttctcgatga 921061 agacgaatat gatgatcatc ggaaagccat gaattatcca aaagaaatcg acagtatttt 921121 aagagactac ttaaatacgc tgctccattg gattcaccag cgtcagggac cgtttgcgcc 921181 cgagtttgtc gatatgtggt atgaacggta tttgcgctat acaaaataat ggttacgtaa 921241 aaacctgttg cggggtacaa caggtttttc acatgggctc acacacatca tgataaagag 921301 agagggggaa tcaaccgtgg gggttatgaa acgctacatg caattcgtca aaccttataa 921361 gaagcaaatt ttcgttacag tgttaatcgg gatcgtaaaa ttctccattc cgcttgctct 921421 cccattgctt ctgaagtacg tagttgacga cattattcaa ggaggcggca cggccagtga 921481 caaaaccacg tcattgttca cgattatggc gatcatgttc gccttatttt taattttgcg 921541 cccgcctgtt gaatattacc ggcaatattt tgcccagtgg actgccagca aggtgcttta 921601 tgatataaga gctaagctgt ttgaccatat acaaaaactg agccttcgtt tttacgcgaa 921661 tacaagaaca ggggaagtca tttcccgagt gattaatgat gtagaacaaa caaaggattt 921721 cgtcatcaca gggctgatga atatatggct cgatatgctg acgattttga ttgtaatctc 921781 tatcatgctc acactggacg ttaaattaac gctgatctct atcgttttat tcccattata 921841 cggaatatca gtgaagtatt tttacggccg tttacgaaag ctgacaaggg agcgctcaca 921901 ggctcttgct caagtgcagg ggcatttgca tgaacgcatt caaggcatgc ctgtcatcag 921961 aagctttgcg atagaagatc atgaacaggc tcaatttaat gagaaaaacg gtcatttctt 922021 agataaagcc atccgccaca cgaattggaa cgcgaaaacc tttgcggtcg ttaataccat 922081 tacagatttg gcgccgctca tcgtcatagc gtgcgccggg tattttgtca ttaatggacc 922141 gctgacagtc ggaacaatgg tcgcgtttgt cggatatatt gacagaatgt acaaccctgt 922201 tagaaggctg atcaattcct ctacaacttt gacacagtca atcgcatcaa tggacagggt 922261 gtttgaattt attgacgagc cctatgaact cactgacaaa ccaaatgcga taaaggccga 922321 tcagattcgc ggaggagtgg agtttcaaaa cgtttcgttt caatatgaga aggacaaaga 922381 aaatattctt catgatgtat ccttaaaagt aaatagagga gaaactgtag ctctcgtcgg 922441 catgagcgga ggaggaaaat caacgctcgt cagcctgatc ccaagatttt atgatgtaac 922501 aagcggcaga ctgctgattg atgggacgga tattcgcgat tatgaagcaa gaagccttcg 922561 caaccaggtt ggtatggtgc ttcaagatac ctttttattt agtgaaacga ttcgggaaaa 922621 tatcgcgatc ggcaagcctg atgccacact tgaagagata atcgaagccg ccaaagctgc 922681 aaatgcccat gaatttatca tgagttttcc agaaggatat gagacccggg tgggggaacg 922741 aggcgttaag ctttcaggcg gacaaaagca gcggatctca attgcgcggg tattcctgaa 922801 aaatccgccg ctcctcattt tagatgaagc tacatcagct ctggatttgg aaagtgagca 922861 ttacattcaa gaagcgatgg acaaactggc gaaggataga acaacttttg ttgtcgccca 922921 ccgtttatcg acaatcaccc atgcggataa gattgttgtc atggaaaacg ggacaatcat 922981 tgaaatcgga acccatgatg aactcatgga ctatgagagc caatacaagc acttatttac 923041 cattcaaaat ttgaactaaa acatcaatct tatatccttt taacgaagga tataagattt 923101 ttttgtatat aaaaaaaccc ggctgtttaa ccgggttact cttctgtttc tatttcgcag 923161 tctttcggat gatacgtttg aaaacttgtg ataagtgttt ctaaatgttc aagctgctcg 923221 cgatattcca cggcgcttgc cataatattg agcatgttgt aatcaataag ctcctcatcc 923281 gtattctgct gattttttaa aaatgacttt gttaaaagct gcttataccg gatgccttct 923341 tcaaccgcgt catcatgcgg cttgattttt ccgacaaacc tcatcaaaat ccgctcgtgc 923401 cagtaaagca ggtaatcaag ttcttcagtc aatgtttcct gaaactcttc cggcatatga 923461 tagatctcgt tttccagacg atgcagcttc ttcaatgtat caagcgcccg atttgcagta 923521 ataatggcct gtctgaacag gacaagcttt cttgatttca cataagtcgt tttcttaaag 923581 taacttcttt cttctttata tagaagatat gtctgatcaa gcttgatcat tttttctttc 923641 agtttttcaa tatcctcttt caaaatcgaa tgctctgtcg actgccgcat ggacaatctg 923701 atccacttca taatttcttc ggtgttttcg acggtattat gaatcagctt tgtttcgtac 923761 ttaggaggca aaaacacaag gttgacgata aaggaagaaa gcacccctaa gatgactgtg 923821 cttgttctga tcagcgcgaa cattaaaaag tcgtcaccgg cagattctaa tatcgcaatg 923881 actgttacaa gagcaattga aattgtatgt tcaattttaa gtttcagcat gattgtaatg 923941 acaataactg ctgttaaccc gatcataatc gggctgggtc cgaaaataag gccgaacact 924001 gtggcaatca cagctccgat gatatttgct tgaacctggt caataataat gagaaaagag 924061 cggtaaatcg acggctggat cgcaaatatc gctgcaattc cagcgaaaat cggcgcggga 924121 agcccgatcc acgaagccaa ataaagggca agtgtaatcg caatcccggt tttgaaaatg 924181 cgggcaccaa gtttcattgg tttgtgcgtg cattcctttc tatagtaaat tgtgtgacat 924241 agcaaatggg ctaatcctta aaattcccgg ttagtttatt tgctaaacaa ttaagtaata 924301 tacagggatc gatacaaata ttcaagctat ttttctagaa aaagaccaaa atcttacacg 924361 ctgtttgatt ccataaaaaa acaggagctc aaagctcctg ttcaaggtat ttgattctag 924421 ttttttagat gtttaaatgc atcctcgacc gctgtaagcg tgtctttaat atcctgctct 924481 gtatgtgctg tggtaataaa ccaagcttca tacttagaag gtgctaaatt aattccgcgt 924541 tccagcatca gcttgaaaaa cgtagagaat gtttctccgt cactccgttc agcctgctcg 924601 taattttcca ctttctcatc agagaagtat accgtgagcg caccttttaa ccggttgacc 924661 gtaatggtga tgccgtgtgt ttctgcgtgc ttcaaaatgc cttcctcaag catagcgcca 924721 aggtgatcaa gcttttcata cacgcctttt tctttgagca cttccagaca agcgatgcct 924781 gataggatgg aagcggggtt ccctgccatt gttcctgcct gataagcagg ccctagcgga 924841 gctacctgct ccatgatttc ttgtttgccg ccataggccc caatcggaag tccgccgccg 924901 ataattttcc cgagtgctgt taaatctggt ttcacctgta agagatcctg cgcgccgcca 924961 tacataaagc ggaaagccgt aatgacttca tcgtaaataa cgagagcccc tgcattatgt 925021 gttaattcat ttacttgttc taagaagccc tctttcggct ccacgatacc gaagttgccg 925081 acaatcggtt caacgagaac cgccgcgatt tcactgcccc atttttcaag agctgcttta 925141 tagctatcga tatcattaaa tggtactgtg atcacttcgt ttgcaatgct tttcggtaca 925201 ccggctgagt ctggtgtgcc gagagtagac gggccggagc ctgcggcgac aagcacaagg 925261 tccgaatgcc cgtgatagca gcccgcaaat ttaatgattt ttgtccggcc tgtatatgcg 925321 cgagccacgc ggatggtcgt cataacggct tctgtacccg aattgacgaa tcttactttg 925381 tccatagcgg gaatggcttc tttgagcatt tttgcaaatg taacctcgtg tttcgttggt 925441 gttccataca atacaccgtt ctctgctgct tttttaatcg cttctgtaat atgcggatgg 925501 gcatgtcctg taataatcgg accgtacgcc gctaaataat cgatgtattt gttgccgtcc 925561 acatcccaaa aataagcgcc gcttgctttc tccattgcaa caggagaacc gccgccgact 925621 gctttatatg atctagacgg gctgtttaca ccgccgacaa tgtgctgtaa tgcctcattg 925681 tgaagttcaa ttgattttgt atgcaagaat aaaaacctcc tatatctcca tgcgtccttt 925741 ctattgtagc atgcttccga acaagaacaa tggcttcggg cttcagattc agctgagatg 925801 gttgtaatct ggacaagaat tggatacgct taataaaaaa acatccggag gtaacgtaat 925861 gactatagaa atcggacaaa aagcgcctga tcttgagtta aaaggtgatc atggggaaac 925921 agtaaaatta tcggattata aaggaaagta catcgtgctt tatttttatc caaaggacat 925981 gacaccggga tgtacaactg aagcatgcga ttttcgggac agtcacgaaa gcttcgccga 926041 actggatgcc gtcattatcg gcgtcagccc ggacagccag gaaaaacacg gaaaatttaa 926101 agagaagcat aaccttccat ttctgcttct tgttgatgac gagcataagc tggcggaagc 926161 atttgatgtg tggaagctga agaaaaactt cggaaaagag tatatgggaa tcgagcgttc 926221 cactttttta attgataaag aaggccggct cattaaagaa tggagaaaag taaaagtaaa 926281 ggaccatgta gccgaagcgc ttcaaaccct caaagatatg tctgaaaagt aaatctctat 926341 gagcctatgc ttacttttac cctgatatca attgacaaat tatcgtagaa agagttacac 926401 taattataaa cattacaatg taagaatttt ttttagaaga gaggtgcatg acggatggct 926461 gcacatgaac taaaagaagc cttagaaacg ttgaaggaaa ccggagttcg cattactcct 926521 caacgtcatg cgattctgga atatctcgtt aactctatgg ctcatccaac agcggacgat 926581 atatataaag ctctggaagg gaaatttcct aacatgagcg tagcgacggt atataacaat 926641 ttgcgtgtgt tccgggaatc aggtttggta aaagagctca catacggtga tgcttccagc 926701 agattcgatt ttgtcacatc cgatcactat cacgcgattt gcgaaaactg cggtaaaatt 926761 gtggacttcc actacccggg ccttgatgaa gtggagcagc tcgctgccca cgtcacgggc 926821 ttcaaggtaa gccaccaccg tttagaaatt tacggcgtct gccaagagtg ttcgaaaaaa 926881 gaaaatcatt aaaaataagc tgaccgcacg aaacggtcag cttattttat ttcgacattt 926941 tctttttatt ataagactca tcaaattctt ttccttctaa tcccttatct aaagtcagcg 927001 gctctcggca atgcatgcac atatcgacta ctcctaaaac ctttgtctct ttatcacagc 927061 ctggacaaat gacgcgaacc gctttagtcg aaagcattcc gatccaaaag taaactaccg 927121 tgctgagacc gatggataaa agcccaagta tcataaacaa actagaaagc aaaactgact 927181 ctttgaaaaa gatcccgatg tacataatga taaacccaac gaaaaccaaa cttaacgcaa 927241 atgttctgat tttattaatt ttgctggagt atttcgccat gtccatcccc ctctgtttta 927301 actatagcac aaacccgatg ggattttctt catgttttcg gttgaactgg aatttacata 927361 tggagagtta ctgtgaaatt gtttataata gttcaatgtg tttagaaaaa aggaatttcg 927421 ttttaaccat agaattgaat caaatagaga ataaaaaaat ttgaacaatt gcattggagg 927481 aatagtgatg gaaaatcttc tccgtccaat ttaccaagaa agagcaagtc accccaatac 927541 attggctgtc attatgattg agagaagaaa caaaacatct tccttaacag ataactttga 927601 tgcagctttg ctggtgattg taaaggatgc tgatgagcca gtttttataa agcattatga 927661 atttgatcat caaacagctt ctttgcatgt ggtaacagat tctcagattc aagaatggat 927721 tttgcttgga acaaatagaa gaatcataga ttggattgta aatggcagag tcttgtttga 927781 ccgtaatgaa tacgtagttg aactgattga caggctgaat acatttccgt ttgccgaacg 927841 taaactgaag atcggactcg aatacggcaa attaatcaga aggtatgttg aagggaaagc 927901 tttttttgaa gccaatcaat ttttagatgc ctacaatgcc gttgttcatg cgctgcatca 927961 tttagcacgt attgaagtaa tcgacagagg attccatccc gaaaccacgg tgtggagcca 928021 agtgcgccag atggagcccc aagtgtacaa attatattcc gagctgattg aaagtcatga 928081 gagcctggaa aaaagacttg aattattatt cttagcaaat gattttctca tccattccaa 928141 agccgagatc ggttcggcgc atcttttcga agtaatgaaa gaaaaagaca tttggcaatt 928201 cggtgagctt cttcaacatc atgacctaaa gcactttacc caagatcttg gcgttatgct 928261 tgattacttg acggaaaagg gacttatcaa cgtctgccag atagaaacga aaggacaggc 928321 tgtctatcac cgaggatatt cttttaaaaa aggtgttgac tctgattctt gaccgtgtta 928381 tattattaaa cgtcgctgat gcgcttctga gaaaacaagc tcacagcggc gggaaaataa 928441 atcaaaaaaa catttgacaa aagaaagtca aaatgttata ttaataaagt cgcttcaaca 928501 agaagtgaaa atgatctttg aaaactaaac aagacaaaac gtacctgtta attcagtttt 928561 taaaaaatcg cacagcgatg tgcgtagtca gtcaaactag ggcctgcacg acgcaggtca 928621 cacaggtgtc gccgcaggat gcggtgaact taacctgtga tccatttatc ggagagtttg 928681 atcctggctc aggacgaacg ctggcggcgt gcctaataca tgcaagtcga gcggacagat 928741 gggagcttgc tccctgatgt tagcggcgga cgggtgagta acacgtgggt aacctgcctg 928801 taagactggg ataactccgg gaaaccgggg ctaataccgg atggttgttt gaaccgcatg 928861 gttcaaacat aaaaggtggc ttcggctacc acttacagat ggacccgcgg cgcattagct 928921 agttggtgag gtaacggctc accaaggcaa cgatgcgtag ccgacctgag agggtgatcg 928981 gccacactgg gactgagaca cggcccagac tcctacggga ggcagcagta gggaatcttc 929041 cgcaatggac gaaagtctga cggagcaacg ccgcgtgagt gatgaaggtt ttcggatcgt 929101 aaagctctgt tgttagggaa gaacaagtac cgttcgaata gggcggtacc ttgacggtac 929161 ctaaccagaa agccacggct aactacgtgc cagcagccgc ggtaatacgt aggtggcaag 929221 cgttgtccgg aattattggg cgtaaagggc tcgcaggcgg tttcttaagt ctgatgtgaa 929281 agcccccggc tcaaccgggg agggtcattg gaaactgggg aacttgagtg cagaagagga 929341 gagtggaatt ccacgtgtag cggtgaaatg cgtagagatg tggaggaaca ccagtggcga 929401 aggcgactct ctggtctgta actgacgctg aggagcgaaa gcgtggggag cgaacaggat 929461 tagataccct ggtagtccac gccgtaaacg atgagtgcta agtgttaggg ggtttccgcc 929521 ccttagtgct gcagctaacg cattaagcac tccgcctggg gagtacggtc gcaagactga 929581 aactcaaagg aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgaagc 929641 aacgcgaaga accttaccag gtcttgacat cctctgacaa tcctagagat aggacgtccc 929701 cttcgggggc agagtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg 929761 ggttaagtcc cgcaacgagc gcaacccttg atcttagttg ccagcattca gttgggcact 929821 ctaaggtgac tgccggtgac aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc 929881 ccttatgacc tgggctacac acgtgctaca atggacagaa caaagggcag cgaaaccgcg 929941 aggttaagcc aatcccacaa atctgttctc agttcggatc gcagtctgca actcgactgc 930001 gtgaagctgg aatcgctagt aatcgcggat cagcatgccg cggtgaatac gttcccgggc 930061 cttgtacaca ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac 930121 cttttaggag ccagccgccg aaggtgggac agatgattgg ggtgaagtcg taacaaggta 930181 gccgtatcgg aaggtgcggc tggatcacct cctttctaag gatattatac ggaatataag 930241 accttgggtc ttataaacag aacgttccct gtcttgttta gttttgaagg atcattcctt 930301 cgaaacgtgt tctttgaaaa ctagataaca gtagacatca cattcaatta gtaatacaag 930361 atatcacata gtgattcttt ttaacggtta agttagaaag ggcgcacggt ggatgccttg 930421 gcactaggag ccgatgaagg acgggacgaa caccgatatg cttcggggag ctgtaagcaa 930481 gctttgatcc ggagatttcc gaatggggaa acccaccact cgtaatggag tggtatccat 930541 atctgaattc ataggatatg agaaggcaga cccggggaac tgaaacatct aagtacccgg 930601 aggaagagaa agcaaatgcg attccctgag tagcggcgag cgaaacggga ttagcccaaa 930661 ccaagaggct tgcctcttgg ggttgtagga cactctgtac ggagttacaa aagaacgagg 930721 tagatgaaga ggtctggaaa ggcccgccat aggaggtaac agccctgtag tcaaaacttc 930781 gttctctcct gagtggatcc tgagtacggc ggaacacgtg aaattccgtc ggaatccggg 930841 aggaccatct cccaaggcta aatactccct agtgaccgat agtgaaccag taccgtgagg 930901 gaaaggtgaa aagcaccccg gaaggggagt gaaagagatc ctgaaaccgt gtgcctacaa 930961 gtagtcagag cccgttaacg ggtgatggcg tgccttttgt agaatgaacc ggcgagttac 931021 gatcccgtgc aaggttaagc agaagatgcg gagccgcagc gaaagcgagt ctgaataggg 931081 cgcatgagta cgtggtcgta gacccgaaac caggtgatct acccatgtcc agggtgaagt 931141 tcaggtaaca ctgaatggag gcccgaaccc acgcacgttg aaaagtgcgg ggatgaggtg 931201 tgggtagggg tgaaatgcca atcgaacctg gagatagctg gttctctccg aaatagcttt 931261 agggctagcc tcaaggtaag agtcttggag gtagagcact gattggacta ggggccccta 931321 ccgggttacc gaattcagtc aaactccgaa tgccaatgac ttatccttgg gagtcagact 931381 gcgagtgata agatccgtag tcgaaaggga aacagcccag accgccagct aaggtcccaa 931441 agtatacgtt aagtggaaaa ggatgtggag ttgcttagac aaccaggatg ttggcttaga 931501 agcagccacc atttaaagag tgcgtaatag ctcactggtc gagtgactct gcgccgaaaa 931561 tgtaccgggg ctaaacgtat caccgaagct gcggactgtt cttcgaacag tggtaggaga 931621 gcgttctaag ggctgtgaag ccagaccgga aggactggtg gagcgcttag aagtgagaat 931681 gccggtatga gtagcgaaag aggggtgaga atcccctcca ccgaatgcct aaggtttcct 931741 gaggaaggct cgtccgctca gggttagtcg ggacctaagc cgaggccgaa aggcgtaggc 931801 gatggacaac aggttgatat tcctgtacca cctcctcacc atttgagcaa tggggggacg 931861 caggaggata gggtaagcgc ggtattggat atccgcgtcc aagcagttag gctgggaaat 931921 aggcaaatcc gtttcccata aggctgagct gtgatggcga gcgaaatata gtagcgaagt 931981 tcctgattcc acactgccaa gaaaagcctc tagcgaggtg agaggtgccc gtaccgcaaa 932041 ccgacacagg taggcgagga gagaatccta aggtgatcga gagaactctc gttaaggaac 932101 tcggcaaaat gaccccgtaa cttcgggaga aggggtgctc tgttagggtg caagcccgag 932161 agagccgcag tgaataggcc caggcgactg tttagcaaaa acacaggtct ctgcgaagcc 932221 gtaaggcgaa gtataggggc tgacgcctgc ccggtgctgg aaggttaaga ggagcgctta 932281 gcgtaagcga aggtgcgaat tgaagcccca gtaaacggcg gccgtaacta taacggtcct 932341 aaggtagcga aattccttgt cgggtaagtt ccgacccgca cgaaaggcgc aacgatctgg 932401 gcactgtctc aacgagagac tcggtgaaat tatagtacct gtgaagatgc aggttacccg 932461 cgacaggacg gaaagacccc gtggagcttt actgcagcct gatattgaat gttggtacag 932521 cttgtacagg ataggtagga gccttggaaa ccggagcgcc agcttcggtg gaggcatcgg 932581 tgggatacta ccctggctgt attgaccttc taacccgccg cccttatcgg gcggggagac 932641 agtgtcaggt gggcagtttg actggggcgg tcgcctccta aaaggtaacg gaggcgccca 932701 aaggttccct cagaatggtt ggaaatcatt cgcagagtgt aaaggcacaa gggagcttga 932761 ctgcgagacc tacaagtcga gcagggacga aagtcgggct tagtgatccg gtggttccgc 932821 atggaagggc catcgctcaa cggataaaag ctaccccggg gataacaggc ttatctcccc 932881 caagagtcca catcgacggg gaggtttggc acctcgatgt cggctcatcg catcctgggg 932941 ctgtagtcgg tcccaagggt tgggctgttc gcccattaaa gcggtacgcg agctgggttc 933001 agaacgtcgt gagacagttc ggtccctatc cgtcgcgggc gcaggaaatt tgagaggagc 933061 tgtccttagt acgagaggac cgggatggac gcaccgctgg tgtaccagtt gttctgccaa 933121 gggcatcgct gggtagctat gtgcggacgg gataagtgct gaaagcatct aagcatgaag 933181 cccccctcaa gatgagattt cccattccgc aaggaagtaa gatccctgaa agatgatcag 933241 gttgataggt ctgaggtgga agtgtggcga cacatggagc tgacagatac taatcgatcg 933301 agggcttaac catatttttg aatgatgtca cacctgttat ctagttttga gagaataagt 933361 ttttcaaaaa aacacttgat tttctcaaga atacatagta taatgttaaa tgtcactgaa 933421 attgtctggt gatgatggcg aagaggtcac acccgttccc atgccgaaca cggaagttaa 933481 gctcttcagc gccgatggta gtcgggggtt tccccctgtg agagtaggac atcgccaggc 933541 agacttcatt ccgcagtagc tcagtggtag agctatcggc tgttaaccga tcggtcgtag 933601 gttcgaatcc tacctgcgga gccattattg gagagctgtc cgagtggtcg aaggagcacg 933661 attggaaatc gtgtaggcgg tcaactccgt ctcaagggtt cgaatccctt gctctccgcc 933721 actgatactt atacataatt acaattgaaa gtctgggccc gttggtcaag cggttaagac 933781 accgcccttt cacggcggta acacgggttc gaatcccgta cgggtcatta tatgatggag 933841 gattagctca gctgggagag catctgcctt acaagcagag ggtcggcggt tcgagcccgt 933901 catcctccac cattatatca tcgcggggtg gagcagttcg gtagctcgtc gggctcataa 933961 cccgaaggtc gcaggttcaa atcctgcccc cgcaaccaaa ttttaaaatg gtccggtagt 934021 tcagttggtt agaatgcctg cctgtcacgc aggaggtcgc gggttcgagt cccgtccgga 934081 ccgccatttg aatacttagg ctcggtagct cagttggtag agcaacggac tgaaaatccg 934141 tgtgtcggcg gttcgattcc gtcccgagcc accacctatg ccggtgtagc tcaattggta 934201 gagcaactga cttgtaatca gtaggttggg ggttcaagtc ctcttgccgg cactgttttt 934261 tcaaaattta atgtggaggg gtagcgaagt ggctaaacgc ggcggactgt aaatccgctc 934321 cctcagggtt cggcagttcg aatctgcccc cctccaccat ttataggggc atagtttaac 934381 ggtagaacag aggtctccaa aacctccggt gtgggttcga ttcctactgc ccctgccaaa 934441 tttatgacat cttgagatta tggcggttgt ggcgaagtgg ttaacgcacc agattgtggc 934501 tctggcactc gtgggttcga ttcccatcaa tcgccccata ttatcattgg gctatagcca 934561 agcggtaagg caacggactt tgactccgtc atgcgttggt tcgaatccag ctagcccagt 934621 ctcacttttt atatcaactg catataatgt attaagtcca ttaaaaatgc ggaagtagtt 934681 cagtggtaga acaccacctt gccaaggtgg gggtcgcggg ttcgaatccc gtcttccgct 934741 ccaattacgg cggcatagcc aagtggtaag gcagaggtct gcaaaacctt tatccccggt 934801 tcgaatccgg gtgtcgcctt cttattgccg gggtggtgga attggcagac acacaggact 934861 taaaatcctg cggtaggtga ctaccgtgcc ggttcaagtc cggccctcgg caccaatttt 934921 acttacatgg taagttgaat tggtgtttgt gttttatcat tataactaat catattaatg 934981 atctacataa gtagatcatt tttttaatgc tttgatttat cataacaagt taagttccga 935041 ggcctattat aaagcggctg tatagctagt ctttcaacac ttttatttta tatttccata 935101 aaaacttttt tgaaatacgt tgacacttta tgagatccat gatatattta tattcgtcgg 935161 ttagatacga cgtaaaactt gccggtgtgg cggaattggc agacgcgcac gactcaaaat 935221 cgtgttcctt ctggagtgtc ggttcgaccc cgaccaccgg tatactgaaa aacccgtttc 935281 ttaacagaaa cgggttttta ttttttatta aagaaaagga gcctcggctc ctttttatac 935341 ttactcagcg tattggtcta ggatctcttc tagcacctct tctagctctt ctgtatcttc 935401 aagctctgat tggctgaaac ggacgcgtac aagctgttct ccgtcattat acatctcttc 935461 caaccaccct cggagtcctc ttgctctgcg gtcgacttcg aaaatgattt ccaaaccgtc 935521 ttcgtctaaa aggaaaatga gctctaattc atcaagcatc tgacgataat atccggaagt 935581 cggaacgaat tcgaattctt gaacgaacgg aagacgacgc tggaagtagg gcgcttgttc 935641 gcagtctgct tcgttaagac ggaagcccag gttttcgatt gcttcaagca cattttcaat 935701 ccaagggtgc gcttcaacga aaatgcggtc atgatcggat ttatcgatac cgccttgaat 935761 gtcaaggtct gtcaccacgg caacctctac tttccctaca gtgatcggcg tatctagagg 935821 cagagtgaat gtgaacggaa attgatgctc ttcaccaggc tgtatggtaa atgaaccagt 935881 gacccggaaa gaatgaattg tagcgtattt ccggtgctct tcatcgtctt ttacaatgac 935941 ataccgtgtg ctaagctgta aatcgatata acggatgtcc tgagcgattt ttccgccttt 936001 gacatgtacc gttccctgta cttcttctcc tggaaaatat gcgtcttttt ctaaaattgt 936061 atctactttt gcagctccaa ttccggcact tgccgcaagc ttcttaaaaa atgacatgtt 936121 agatcttccc ctttttcttt tttctcaaca gatatacgta agaaggagga aaaaagattc 936181 gtttgattca tacttttttc ctattattcg tctcggccta gggacagact aagaataata 936241 ttgaaaataa aggagtcgat ggaagtgaat aaagaaagtt tggttgcaga tgaattacac 936301 agaatgtttt tggctggtga gctgcaaatc acagtagagg aggatataaa caatatttcc 936361 gaaaggctga gaaacggcga tctcagttta gaccgattaa gcggtgaaga cgtgtttata 936421 aaagaaacgg taaatgaggc tttaagaaga gtggagcaat aaaaaagaga cggcatctca 936481 tctttgagat cccgtctctt tttgtggtct ttgctgtaag ataaaagcga atcgatttgg 936541 aattgctcac ccgagccacc ccttttctaa cagaagatct gacagttcat catggagata 936601 aacagctgta tctaattgat catgcaatgc tcttctgatg tggggatttt cggttgctgt 936661 tgttgcgaca gtgtatttgt taatgctggt ttttattgtt gttaacaaat caagaatatc 936721 tttgggacaa agactttgtt caatgggaaa ccacctcctt tgttttttta gcagctcctg 936781 ataagaaagt atttgacttt gtttcttgct tctatacaaa atgctataat aagcaacaaa 936841 ttttgttggg gggtgtgatg atgaagcaga ttattgcgat ggggggcggg ggtttttcga 936901 tggagccgga taatttgtcc ctcgatcaat atatcctcaa tcaatcaaaa cgagagcagc 936961 ctcgtatttg ttttttgccg acggcgagcg gagattccca aaactatatt cagcggtttt 937021 atcatgcatt tcaaacattg gattgcgtgc cgtctcattt atctttgttt aagccaccat 937081 catcagattt agtttctttt gttatggaaa tggacgtgat ttatgttggc gggggaaata 937141 cgcggaattt acttgtgtta tggaaagagt gggggctgga ccatattctc agggaagcat 937201 ggaagaacgg tgtggttgta gctggaataa gtgccggtgc gatctgctgg tttgaagaag 937261 gggtgacaga ttcagccgga ccgctgacaa gtttgaaaag tttaggtttt ttgcaaggga 937321 gcttttgtcc ccattatgac ggggaaaagg atcggagacc ggcataccac cagctgatat 937381 ctaacaagtt cttatgcagt ggctatgcag cggatgatgg ggctgctctc catttcataa 937441 atgatcagct gtttcagact gtgagttcaa ggtcgggtgc aaaggcatat cgggtgatga 937501 tggctgaaca tgaaatagct gaaatcccgt tgccggtcaa atatttaggg tgaaattggc 937561 tgaatattat ctatattcct ctttttttca gattgatttt atgataagat gagtgcgaaa 937621 tcaatagtta ctgggggtgc ccgctttcgg gctgagagag aaggcaagct tcttaaccct 937681 ttggacctga tctggttcgt accagcgtgg ggaagtagag gaattgtttt tgttattgtc 937741 ttgctgggca ataatatgtt tctttctgac tgtaaccggg ttcatttata tgaatccggt 937801 tttttgtgct ggttatgggc ttgattttgt cctttcaaac gtagaaaggg gaaggaaaag 937861 taatgcaaaa caattcagtg cagcaagcca acatttccat tatgtcaagt ttttcaggca 937921 gcaagaaggt atacgtggag ggttcttctt cggacatcca agtgccgatg agggagattg 937981 cattgagtcc gacgacggga tcgttcggcg aagaggaaaa cgcgcctgtg cgtgtctatg 938041 atacaagcgg accgtatacg gaccctgaag taaccattaa tattcaagaa ggattaaagc 938101 cgctccgcca aaaatggatc acagagcgcg gtgacgtgga agagtatgaa ggtcgggcta 938161 taaaaccaga agataacggt tataaaaaag caaaaccaaa cgtaagctat ccaggattaa 938221 agcggaaacc gctgagggcg aaggcaggtc aaaatgtcac acaaatgcac tatgcaaaaa 938281 aggggatcat tacacctgag atggaattta tcgccattcg tgagcatgtg tctcctgaat 938341 tcgtcagaga cgaggtagcc agcggccggg cgattattcc ttcaaacatt aatcaccctg 938401 aaagtgagcc aatgattatc ggccggaatt ttcatgtgaa gattaatgca aatatcggga 938461 attcagcggt tacgtcatcc attgaagaag aagtggaaaa aatgacgtgg gccatccgct 938521 ggggagcgga tacgatgatg gatctctcta ccggaaaaga tattcatacg acgcgtgaat 938581 ggattatccg caattgcccc gtgcctgtgg gaactgttcc gatttatcag gcgcttgaaa 938641 aagtaaacgg cgtagctgag gatttaacgt gggagattta tcgtgatacg ctaatcgagc 938701 aggcagagca gggagtggat tattttacga ttcacgcggg tgttttgctt aggtatgtac 938761 cgctgactgc caaacggaca actggtatcg tgtcacgcgg gggagcgatt atggcgcagt 938821 ggtgtctggc tcatcatcaa gaaagctttt tatacacaca ttttgaagaa atatgtgaga 938881 ttatgaaaat gtatgatatt gctttctctc ttggggatgg tttgcgtccc ggatcaattg 938941 ctgatgccaa tgacgaagcg cagtttgctg aattagagac gcttggagag ctgacgcaaa 939001 ttgcctggaa gcatgatgtt caggtgatga ttgagggtcc tggacatgtt ccgatgcata 939061 aaatcaaaga gaacgtcgat aaacaaatgg acatttgtaa agaagcgcct ttttacacat 939121 tggggccgtt gacaacggat attgctccgg gatatgacca tattacttca gcgatcggag 939181 cggcgatgat cggttggtac gggacagcaa tgctttgtta tgtaacgccg aaggagcatt 939241 tggggctgcc aaaccgtgat gatgttcgtg aaggagtcat tacatataag atcgctgcgc 939301 acgctgcgga ccttgcaaaa gggcatcccg gagcgcaaat ccgggatgat gcgttatcga 939361 aagcccgttt tgaattccgc tggcgggatc agtttaattt atctcttgat ccggagagag 939421 cccttgaata ccatgatgaa accctgcctg ctgaaggagc aaaaaccgct cacttttgtt 939481 ccatgtgcgg tccgaaattt tgcagcatga gaatttcaca ggatattcgg gattatgcga 939541 agaaaaacga tctcagtgaa gcagaagcca taaataaagg attaaaagaa aaagcaaaag 939601 agtttgtcga tacgggaagc aatttatatc aataaaaaaa atgaagatgg agaatgctcc 939661 atcttcattt ttttagaaaa acagagagcg tcgaagcgga ggaatactct gttcaaagcg 939721 gaaaacattt tctggatcat atgtcgtttt gacacggcgg agtcgttcaa cgttttcgcc 939781 gtaatatgtt cttggccagt ttctgatttc gatatctggc caatttacgt agtctcccat 939841 cgtttctttc gaaagggacg ttctcagccc ctcaatccag cggacatttt gtcttttttc 939901 tccaggggat gtccagtttg ttaagtattc ctgggcgatg attgcgtcac gataataaaa 939961 tgccgtttgg tcgggagcga cccgtccggc tgccccgccg agtgcttgct gccagacact 940021 ggcgttttga ttcggagcgt gctctaaaaa gtgttttatt gttgagatcg cacgttctga 940081 taatggcttt tcaatgaaag agccggagcg tttcattttt tgaggctgat tgcctcccgg 940141 gctgttaaaa aaggttaccg cttcaatgaa tggcgttgtt tttaccattc cgcttgtcgg 940201 acttcctgct ttcaataaag gctttaacag tttttttaac tctgtttttg gcccgacaaa 940261 ttggccgagg gcttctatgc ggtttacttc tttaggccaa aactctattg atgatgtaag 940321 ccggtcatct gtatacgggg cccagttctg ccacgtgtta tatacttcct caaaatcatc 940381 ccatccccat gtaatagaaa aaatcgacac ttgagagatg ggcactgctt taaatgtcat 940441 ggaggtgact atgccgaaat tgcctcctcc gcctccctga gacgcccaaa ataagtctgg 940501 atgatttgaa cagctgactg taatcagatc agcgccctct ttttcgtctg ctacgatcat 940561 ctcaagctgc acgaggctgt cgcaagtaag accggcagcc cttgttaaaa gtccaattcc 940621 ccctccgaga gttaaacctg tgagccctac attagcaatg gtgcctgcgg gaagcgtcag 940681 gccgtattgc cagagtgtcc gatagacttc tcccaattca gcccccgctt caatataggc 940741 cagcttttta tcctgattca cagttatttt tttcatctcg cttaaatcaa taacaagacc 940801 gttatttaaa agggaaaagt tctcatagct gtgtctgccg cctctaatac ggaaaggcac 940861 acggttttca cgcgcccatt tcagcgcatt gagtgcatcc tgtttgtttt ggcaaaacac 940921 aatgatgtca ggataccttt ctaagcttag gttaatattg gttcttgctt cgttatagtc 940981 cggatcatcc cgtgtcacga tacgtccggt caattttgtc ttttccacac tcccacatct 941041 ctttctctcg tattctagtt tctctagctt atgcgtcagg ggaaaagagt gtataaggaa 941101 aaagcgggga tgcaatctga tacagtgtca acaccctcaa aaaatagttg acaggtcggt 941161 attgtatgaa ttaacatggt cagtacaaat ttttcaaatt tatcgcgctg atcggaacac 941221 cgaaggctct tatcgtttag ataagggcct tttttgtatg aaaaaggggg gattattgat 941281 gggagtcaaa aaagaaaagg ggagaaaacg attcaggaag cgaaaaacct acgggaatca 941341 gattttgccg cttgagctgc tgattgaaaa aaacaaacga gagattataa acagcgcgga 941401 actcatggaa gaaatttata tgaagattga tgagaagcat acgcaatgtg taactaaata 941461 taaaaaaacc cgctgactac aacgggtttt tgcatttctc cattaagaat cttttttaat 941521 cggcaatcca aggccttctg ccacgcgttt tccgtattca ggatccgctt tgtagaagtg 941581 ctcgatttgg cgcagcttga tttcttcttt ttctaccggc ttcatggcat taacgatatt 941641 ttcaacaagg cgggtacgtt catcttcact cattaaacga tacagatcgc cggcttgagt 941701 gtagtgatcg tagtgatcgt agcttacgct gtcagcgata ccttgtaccg gatatgctgc 941761 ttgcttatcc tcaggtgact cttttggacc gccgaagctg ttaggctcgt aatacacaga 941821 tccgccgccg ttatcatcaa aacgcatttg cccatcacgc tgataattgt ttactttgtt 941881 gcgtgcgcgg ttgattggca gcgcttgatg gtttgcaccg acacggtagc ggtgtgcatc 941941 atgataagca aaaagtcgac cttgaagcat tttatccggt gaaacatcaa taccaggcac 942001 gagggttcca ggtgaaaatg tcgcttgttc tacctctgca aagtagtttt ccggatttct 942061 gtctagaacc atgcgtccga cctcgattaa cgggtagtct ttttgagacc aaacttttgt 942121 gacatcaaac ggatcgaaac ggtacgtatt tgcatcttct aaaggcatga tttgcacata 942181 tagtttccat gcaggataat caccgttttc gattgcgttg aaaaggtctt ctgtatggta 942241 atcagggttt tcaccggcaa tttttgctgc cgtattgaca tcaaggtttt tcacgccttg 942301 ttctgtttta aagtgatatt taatccatac gccttcgcct tcggcatttg tccatttgaa 942361 tgtatggctt ccgaagccgt gcatgtggcg aagtgtcgca ggaattccgc ggtcagacat 942421 caggattgtc acttggtgca gtgactctgg tgaaagtgac cagaaatccc atacagccgt 942481 agggtttttc aggtgtgttt ttggatctct tttttgtgta tggatgaaat cagggaactt 942541 aatcgcatcg cggataaaga atacaggcgt attgttgccg acgatgtcgt agtttccttc 942601 ttcagtataa aatttaacag caaatccgcg cgggtcgcga actgtgtcag cagagccaag 942661 ttcaccggca actgttgaga aacggatgaa caacggtgtg cgtttgccga cttcagaaag 942721 gaaagcggct ttcgtgtatt ttgttacgtc gtttgtcact tcaaaatatc cgtgtgcgcc 942781 tgctcctttg gcgtgaacaa cacgttcagg aacacgttct cggttgaaat gggccaattt 942841 ttcgagtaaa tgtacatctt gaattaaagt tggtccgcga gaaccggcag tcattgagtt 942901 ttgattatct ccaaccggag cgccccagct agttgtcagt ttatttgaac tcatgttatc 942961 acctcttgga atttataaga acataatatc atctctaagt aaaaagtcaa tattatttta 943021 taattattat aaaatagtta tctctattaa tcgatatata gtatcgaaat tgttgaaaaa 943081 ccttgttgta acagcttttt atgacactta ataatttttg gagaaataat ttttccttct 943141 ctatttgcga aacaagcaga gtaagtgata aacaaggata tcaaaaatcg tatttaaaaa 943201 agagttgaca tatcggaata atttgaatta acatgttatt caaacaaaaa aacaattggg 943261 cagctgatcg gaccgccgaa ggctctcatc tctacaagaa cagagatggg ggcctttttg 943321 ttttttttga aggcggggtt ggcagaaaga gagggataaa agtggctgtg accatcagca 943381 tcaaagaaaa ggcatttgtt caagaaggcc gcaaaaacac ggtcttagaa aacatagaat 943441 tatcaatcgc accaggcgaa tttctaacgc ttatcggacc gagcgggtgc ggaaaaagca 943501 ccctgttaaa gattattgca gggcttgatt ctgaatatga cgggagtgtg gaaattaacg 943561 gccgcagcgt aacagctccg ggtattcagc aaggatttat ttttcaggaa caccgcctct 943621 ttccttggct gactgttgag cagaatattg cagccgactt gaatttgaag gacccaaaag 943681 tcaaacaaaa ggtggatgaa ctgatcgaga ttgtcagatt gaaaggatcg gaaaaagcat 943741 atccgcgcga gctgtcaggc ggcatgtcac aaagagtagc catcgcccgg gccctgctgc 943801 gggagcctga ggtgctgctt ttagatgaac cgtttggtgc actcgacgct tttacaagaa 943861 aacacctgca ggacgtgctg ctggatatat ggaggaagaa aaaaacaacg atgattctcg 943921 tgactcatga tatagatgaa tctgtttatt taggaaatga gcttgcgatc cttaaggcca 943981 aaccggggaa aatccataag ctgatgccca ttcacctggc gtatccgcga aaccggacga 944041 ctccggattt ccaagcgatc agacagagag tgctgtcgga attcgagaaa acagaagatt 944101 tggagtacgc agaaggatca gggatataga aagggcggaa gcggaaatga aaaaaggact 944161 cattgtattg gttgccgtta tttttctgct cgcaggctgt ggagcaaatg gagccagcgg 944221 tgaccacaaa caattgaagg aaattcgtat tggtattcag caaagcttaa gccccctttt 944281 gattgcaaaa gaaaaaggct ggttcgaaga tgcatttgaa aaagaaggca tcaaagtgaa 944341 atgggtggag tttcaaagcg gtccgcccca atttgaaggc cttgcggcag acaaacttga 944401 tttttctcaa gtcggtaatt cgcctgtgat cgctggacag gcggcaggca ttgactttaa 944461 agaaatcggt ttgtctcagg acggcttgaa agcaaacggc atccttgtca atcaaaacag 944521 cggcattcaa gacgttaagg gcttaaaggg gaagaaaatt gcagtcgcca aaggcagcag 944581 cgggtttgat tttttgtata aagcgcttga tcaagtgggg ttgtcagcta acgatgtgac 944641 aattattcag cttcagcctg atgaagcagc ttccgcattt gaaaacggat ctgttgatgc 944701 ctggtccatt tgggagccgt acttgtcctt agaaacaatg aaacacggag caaaaatcct 944761 tgtgaacgga gaaagcacag atttatattc accgggtttt actttagtaa gaacaaagtt 944821 ttcagaagag catccagacg aagtggtccg ttttctgaag gtgtttaata aagccgttgt 944881 atggcaaaag gaacatctgg atgaagcagc ggacttatat tctgacatta aagatctcga 944941 taaaaaggtc gtcgaaaatg tgctgaaaaa tactgagcca cttaatgaga tcatcagtga 945001 cgacattgtg aaagcacagc aggaaacagc agattttcaa tttcgaacaa aggcgataga 945061 taagaagatt gatgtgaagg atgttgtcga taacactttt atcaaaaaag cattagagga 945121 gcattcctca ggaggtgatc aatgatgaaa gcagaggctg cgggctcgct gcccaaaacg 945181 aatgcggaag cggtgcgaaa aaagcccgga aggaagagat acggctggat gaaggggctt 945241 ttactgcccg ctgtcatcat tgccatctgg caggtcatcg gcgggctggg ggttgtgtcc 945301 gctacagtgc tgcctacacc tgttacgatt gttctgacct ttaaggagct tattttgtcc 945361 ggcgaactgt tcggccatct gcaaatcagc atttatcggg cggcacttgg ttttttgctt 945421 ggcgcggggc ttggattgat gatcgggatt ttggccggat tttccaaacg gacggagctg 945481 tatcttgatc cgtcgttgca aatgcttaga accgtacctc atctggccgt cacgccgctg 945541 tttattttat ggttcggatt tgacgaagta tctaaaattt tgctgattgc gctcggtgcc 945601 ttctttcctg tctatatcaa tacgtttaac ggcatccgcg gggttgacgc gaagctgttt 945661 gaagtcgccc gggtgcttga atttaaatgg catcagcaga tatccaaagt gatattgccg 945721 gcagccctgc ccaatatatt gctaggcatt cgcttatcgc tcggcattgc atggctcggg 945781 ctcgttgtgg cagagctgat gggctcaagc tcgggagtcg gctatatgat catggatgcg 945841 agacagtttt cacaaacgaa taaagtcttt gcagggatta tcatttttgc agtggttgga 945901 aagctgacgg attccttcgt caggctgctt gaacgaaagc tgttaaagtg gagaaacagc 945961 tacgaaggat aaaagatata aaggggagat gaatatggaa attctttggt ttataccgac 946021 tcatggagac gcgagatatt taggatctga aagtgatgga cggactgcgg atcatcttta 946081 ctttaaacaa gtcgcgcagg cggcagacag gctgggatat acaggagttc ttctgccaac 946141 gggaagatcg tgcgaggacc cgtggcttac agcgtcggca ctggcaggag aaacaaagga 946201 cttaaagttt ttagtcgcgg taagacctgg tttaatgcag ccttctctgg cagccagaat 946261 gacatccacc ctagaccgca tttcagacgg ccggctgctg atcaacgttg tggcaggggg 946321 cgatccgtat gagctggcag gcgatggcct gtttatcagc catgatgagc gctacgaggc 946381 aacagacgaa tttttaaccg tttggcggag acttttgcag ggagaaacgg tttcctatga 946441 aggaaagcat ataaaagtgg aaaacagcaa tctgcttttc ccgccgcagc aagagccgca 946501 tccgcccatc tatttcggtg gttcgtcaca ggctggaatt gaagctgccg caaagcatac 946561 agacgtgtac ttgacatggg gtgagccgcc tgaacaagta aaagaaaaga tagaaagagt 946621 caaaaagcaa gcggcaaaag aagggagatc cgttcgattt ggcattaggc tgcatgtcat 946681 tgcccgtgaa actgaacaag aggcatggga agcggcagag cgcttgatca gccacttgga 946741 tgatgacacc attgccaaag cgcaggcagc tttgagccgt tacgactctt caggccagca 946801 gcggatggcc gtccttcatc aaggcgatcg gacgaagctt gaaatcagcc cgaatctgtg 946861 ggcggggatc ggcctggtca gaggaggggc aggaacagct cttgtcggtg atccgcagac 946921 gattgccgac cggatagcgg agtaccaggc actcggcata gaatcgttta tattctccgg 946981 ctatccgcat ttagaagaag cgtattattt tgcagagctt gtatttccgc ttttgccgtt 947041 tgaaaatgat cggacgagaa agcttcagaa caaaagggga gaagcggtag gaaacactta 947101 ttttgtcaaa gagaaaaatg catgagttta actaaaatac agccccccga acatggtatg 947161 atattcaaaa aaagggggct ttttttctga aaacattgag aagcgcggca gtcatttgcc 947221 tcatagctat gctgtcagca tgcggacatt caaaacagat ggaaatcaaa gcggcggaca 947281 tatcagatct tgaaaaaaac agaatggatg tcgcagcttc acaggcattc actgccgaag 947341 ccgtcaatat cggtgaaggt atttcttcag ctgacatgta catcgaacat tatcaaaagg 947401 gaaagcttgt tgagaggttt ggaccggttc gtgcagatta ttcagaggaa aaaactgata 947461 ccatacaatt tgtttatttt gagaatgaag agggggaagg aaagaataaa cataccacca 947521 ttcattttgg cattgtggat aaacagggaa ctatagcggc tgattcatcg gtgaaacgcg 947581 acgatagcac aacacaggaa atgactcaga atatttcatc gccggaaccg attactttcg 947641 agaagcctgc tttgatcggc agcagtatta gagggactga cgagacaatg cacacctctg 947701 aacataaaaa agagctcatt aagcatcaag atgcgttact gtattatgtg gaattgcatc 947761 attagaatgg gcggcttcag gccgtctgtt ttacaaagcg gtatgcttgc ttttttgaat 947821 ggtgaatgat acattttaaa tcgtaacaat ttcgatttaa agggaggcta tgtgacttgg 947881 ctaaaaaatc aaaagtggca aaagagttaa aacgccaaca gcttgttgag caatacgctg 947941 gtattagacg cgagttgaag gaaaaaggag attacgaggc actcagcaag ctgccaagag 948001 attcagcacc gggaaggctt cacaaccgct gcatggtaac ggggcgcccg agagcatata 948061 tgaggaagtt taaaatgtcc agaatcgctt tcagggagct ggcccataaa ggccagattc 948121 ccggtgtgaa aaaagcaagc tggtaagaaa aaactccggc cgattacagc gcgccggagt 948181 ttttttcgtt tttcttgaaa gagatgacgt aggaaaggtg ctggatgatc atgatgataa 948241 acacaataat aatagggaaa aacggaatgc gcgattgaaa tagcggataa aaaatgagaa 948301 gaaccgctgc ggcaggcagc gagaagtaga cagcgatata tgacgcgcga catgcttttg 948361 ccgtcatcat ctgctctctt tcatcctgct cttcaaactc atcaggcaga agtagctgct 948421 ttctggcagg gcggcttttt ttctgtaagt acaaataaac cgcagacgcc gcaacaaaca 948481 gaataaaggg agtgaggttt aaatcaaata ccatcccgcc gctctttgtg ccgaaaaaag 948541 atgctatgcc ttctgaggct tcaaagtatg aaatcagcgc ccagcatgca aggccaaata 948601 aaacaaggtg aaaagctgct tttgttttca tgctcatctt agttttcctc ctctaaccaa 948661 aagacatcct ccattttcat ggagaaggct ttgcagattt tcagtgctaa cagcagtgag 948721 ggaacataat cgcctttttc aatcgctgcc acagtctgtc ttgtgacgcc gaccgtttct 948781 ccgagttttt cctgagaata gccgaagcgt gccctcagct cttttacttt atttttcatc 948841 atgacgtctg tccccttcac aatctcgatt gattatattg tatagtatac ttaacattat 948901 gtaaatggaa cttaacaact ttacaaaaag ataacttttt ttcgacaaaa tttttatatt 948961 cccttgacga aaaataaata aacatgtaat ataaaaaaag tcagagcggt actgttgctg 949021 acaatcacaa atgcgggtgt agtttagtgg taaaacctca gccttccaag ctgatgtcgt 949081 gagttcgatt ctcatcaccc gctccataca tacgttatta acgcagtgtt tcgtttctca 949141 gataaacgaa gtattgcgtt tttttatgtg aaaaagaaca cggtattcgt gttcttttac 949201 gtaagccaat gtactgtatg ggtgccgccg tgaatttgtt caaacatttt cgttaatgat 949261 gataagaggt taacagcgct gcttttctca atcgatggcg ggaaaaaaat gatttgcagc 949321 atattcttag tctcgtttga aacgggatag tggttgacgc tgtttttgaa atcgccaaaa 949381 atgccgtttt catcagagaa aagcagtatg ttttcttttt ctcccaatga gatccggacc 949441 ggctcatgaa gctttccggc atcataaatc ataataggca gagaatattt taatgcgaaa 949501 aaatcgattg tgtcatgggc cgagtcttta ctttccatga attgttcctt ggatatcggg 949561 accagcatgt cctccattgg ggttgtttct ccctcaaatg aagggttaag ctgtttaaag 949621 agtttctgcc attccttgac gaaggattca tcggatatac cgccgtccgc atagtcgaaa 949681 aacaaggatt cttgaaacag gcggagtctg cctttcagca tttgcggtga ggagccgact 949741 tcgatattct cataaatgac agcagctgca tgtaagccgg ccgcacgttc agtaataaca 949801 gaatcaagtt tgatattcac tagcattcac tccagttacg tgatatcaac ctattataaa 949861 cgctgtgtcg ttttatcaca aagaaaggag gctgtgcaaa acatgaacgt ttatcagctc 949921 aaagaagaat taattgaata cgcgaaaagc attggcgtag acaagattgg ttttacgacc 949981 gctgatactt ttgacagttt aaaagaccgt ttgattcttc aagaatcact cggctatctc 950041 tccggctttg aagagccaga tatcgaaaaa agggtgacgc cgaagcttct tttgccgaaa 950101 gcgaaatcaa tagtggcaat tgctctcgca tatccttcca gaatgaagga tgcgccgaga 950161 agcacgagaa ctgagcgcag gggcattttt tgcagagctt cctggggaaa agactatcat 950221 gatgtgctga gggaaaagct tgatctgctg gaggattttc taaaaagcaa gcatgaggat 950281 atcagaacga agtcaatggt tgatacaggt gaattgtctg atcgcgccgt tgcggaacgt 950341 gccggaatcg gattcagtgc gaaaaactgt atgatcacaa cacccgagta tggctcttat 950401 gtgtatttgg cggaaatgat cacaaatatc ccttttgagc ctgatgtgcc gattgaagat 950461 atgtgcgggt cctgcacgaa atgcttggac gcctgcccaa cgggagcact ggttaatccc 950521 gggcagctta atgcgcagcg ctgcatctct tttctgaccc agacaaaagg atttttgcct 950581 gatgaattcc ggacaaaaat cggaaaccgc ctgtacgggt gcgatacgtg ccaaacggta 950641 tgccctctca ataaagggaa ggattttcat cttcatccgg aaatggagcc tgatcctgag 950701 attgccaaac cgttattgaa gccgcttttg gccatcagca atcgggaatt taaggagaaa 950761 ttcgggcatg tctcaggttc ttggcgcgga aaaaaaccga ttcagcgaaa cgccattctc 950821 gcgcttgccc attttaagga tgcttccgca ctgcctgaat tgacggaact gatgcacaag 950881 gatccgcgtc ctgtcatcag ggggacagcc gcatgggcaa tcggaaaaat cggagacccc 950941 gcctacgcgg aagagcttga aaaagcgctg gaaaaagaga aggatgaaga ggcaaagctg 951001 gaaattgaaa aaggaattga gttgctaaaa gcttcaggca tgactaaaca aggcctgtcc 951061 tgacatacgt atagagcaga aggaaaaaac acttgagatc atccaagtgt tttttctcta 951121 taaaaaagta tggcgggtgg ggtgagcttg aagtacattt tagaacaatt agcggaggag 951181 cggctgggct ttctggttaa cgggcatgct atgagacagg agtctcaagt cggagacctt 951241 aaagtcatgg agcgtaagaa aaagcttctg gaaaaacgta aagttgacat cataaaagcg 951301 aaagcaaagg ccgtgattaa tcatgtgcgg gttgaggatg acggaacgac ctgcctttcg 951361 tataccatcc attacgaata cgtgtgtaag gaacaagatg acagcttgta tatagaagag 951421 cacatagagg agcgaatggc tttcctgtat gatcacattt tgattagtga tcaggaaatt 951481 gcgaaaaagc cggctggatt tcatgaaggg accagtatta ttgactattc tgaagctgaa 951541 gaggaaagag aagcgtttgg cagggctttt caatacgatc gtctcggcgc tgtccaatat 951601 gccgagaaat tttggaacaa gcgcaatcct gcttataaaa atttcagcga taactgtaca 951661 aattttattt ctcagtgtct tcatgcagga ggcgcgccga tgcgcggtca tccgaacagg 951721 ggatcaggct ggtggatgaa acaaagctca tggagctaca gctggacggt ggctcactct 951781 atgaaaatgt atttgtcgaa ttcaaaggcc ggactgcgtg cggtgcgggt gaaatcagcg 951841 gaagaactga tgccgggcga tgtgatttgc tatgacttcg aaggagacgg ccggtttaat 951901 catacaacga ttgtcgtggc aaaggacaaa ggcaatatgc cgcttgtcaa cgcccagact 951961 tatgacagca ggatgaggta ttggtcatat gaggattcta cggcatacac gccgtcaata 952021 cgatatgcct tttttcatat cgttgatgat acgacaaaag agtaattaat gttataatga 952081 tgggcggata agaaaaacag aggtgaacat tgtggcatta catgtcgttt tatatcaacc 952141 agaaattccc gctaacacag ggaatattgc acgtacttgt gcagcaacca atacaacgct 952201 acacctgatt cgtccgctcg gcttttcaac ggatgataaa atgctgaagc gtgccggact 952261 cgattattgg gagtttgtta acgttgtgta tcatgattcg ttagaagaat tgtttgaggc 952321 atataaaaaa ggcaagtttt tctttattac aaaatttggc cagcagcctc atacatcatt 952381 tgattacact gatcttgacg aggattattt cttcgtgttc ggaagagaaa caagcggttt 952441 gccaaaggat ttaattcaaa ataatatgga ccgctgcctg cgtcttccga tgacagagca 952501 tgtcagatcg ttaaatctgt ccaatactgc cgcgattctt gtttatgaag cgctgcgcca 952561 gcaaaattac cgtgatttaa aatagtgaaa aacccgctca tcgatgatgg gcgggttttt 952621 ttgcggatgt tgaaatgctt tgtttcgttt ttgggcttaa caacgtaaca gtgttatgtt 952681 acaatgtacc catcaaagga gctggactta tggaagaaca attaatctct aaaaaagaat 952741 tacttgaaag aacatcgatt tcatacggtc agctgtatcg atggaagcgg aaaaacttaa 952801 tacctgagga atggtttatt cgtaaatcca catttacagg gcaagagacg ttttttccga 952861 gagaggagat tttaaaacgt atatcaatga ttcaaaagat gaaagaaaat ttgtctttgg 952921 atgaaatgag ggaaatgctg tcgccgaaaa tgaaggatgt cagcatgacc gctgatgaat 952981 tgcttcataa aggtttggtt tcaaggcctg ctcttgaagc ctattcagaa gacggaggaa 953041 gtccggtttt ttcatccagc gatttgcttt cgctgtttgt gcttgagggc ctgctgcagt 953101 ctggaaatgt cagccttgca gaagcaaaaa tggctgcaga ggtattaaag aagcatgata 953161 ctgaagagat tgaaaaacag acggagctga ttgtgctccg caagctcggt gtcacaactt 953221 gttttatagc ggctgcggcg gacagcattt tgtttgaatc atccgtaaag gttgtggaac 953281 gggtagattt attaaaagct tcagaggaat taaaaacaac atttatgcag gagggccatc 953341 aatggatgta gtggaaaagc tggtgataaa tggatcagga agttctaagg gaggaacatt 953401 tcaatcagtt gagattaatg gcagcgggac agtggccggg gacgtggagt gtgacacttt 953461 ttcttttaat ggaaacggaa aagcggacgg cagcgtcaaa gcgaaagcgg taactatcag 953521 cggttcagga aagatacatg gagacgttga agcagaatct atccggatga atggcactgg 953581 ttttattcaa ggagaggtat ctgcaaaaca attgaaaatc gctggatcat caacatttgg 953641 cggcactgtc aaggctgatg gaattgacat tagcggaaaa gctgtcatgg aagcagattg 953701 tgaaacagaa acctttcaat cagaagggaa atgcaaaatc agcgggcttt taaatgcaga 953761 ccaggtgatc attaagcttt ctgcagggga aagctatgcg cgggagatcg gctgccgcca 953821 tcttcaagtg acctgcagaa aaggaatgct gacattgctc agattgatgc cgcagcctgt 953881 tctaacagca gagctgatcg aaggtgacgt gattgaattg acaaatacaa aggcgaaaac 953941 cgtgcgcggt aataaagtga tcatcggccc ggattgccag attgaaaccg tcgaatacag 954001 cggggactat acctgtgatc caagcgcgtc ggttgaaaca tccacaaagt tgtaaggagg 954061 atcgtaatgg agacaacaaa actgggaaat ttaaaattat atggcgctgg gcatgccgca 954121 ggaggcgcgt atcacaatgt cagcatcaaa ggagaaggta tagttggaga agggctgtct 954181 gctgtaggct gccgcatata cggaacgggc ctttttctcg gaaaagcaga gactgagcgg 954241 ctgcgtgtgc tcggagaaag tgaatgtaaa ggcgatctga cagccggcaa aatcaatata 954301 tatgggacaa tgaaagtcag cggctcactt caatttgatc gattcaatct gaaaggccag 954361 actgaaattg gcgggaatat gactggagaa tcctgcgatg tgaaagggaa gcttagcgta 954421 ataggtgatt gtgaaacaga aatgttccat gtcacaggct gtgttgatgt atcggggtta 954481 ttaaattcgg gtgagatcaa gctgggattg agccatgata taagccatgt gcaggaaatc 954541 ggcggaacaa caattacagt gaaaagacgc gcgagttttt ttagccggaa gaaagggaag 954601 ctgatcgccg atgtcataga aggagatcgg gtttatttgg agaataccga agcggcagtt 954661 gtcaggggaa aagaagtgat catcgggccg ggatgcagca tcggaacgat tgagtacgaa 954721 tacaaatgtg aatgcgatcc gcattcacag attaaagaaa aaacaaaact gtaaaacatt 954781 gttctgttat acaaaaaggg tgctctttca ggagcaccct tttttattct tttccaggct 954841 tgctttcgta tcctgcggta aaaattgata ctaaaaaagt gacaatgaca cccatcatga 954901 tgattgtttt caccgtctct ccccctcttc aatttttccg tgctgtccga gtctggatga 954961 ttctgtattt ttctttatta tgaacggtcg cagtctgcct tgtcaacgat gtatgagtat 955021 ctttattttt aagaaaccaa agcatgtatc acgagatggc ggcatagatt gtatcaaagt 955081 accttatttg catagtgtat caaacatgat agaggaggtc cttatggata tattaaagaa 955141 aattgaaaag tacagagagg aagagcagcg gctgaaatgg gaaggaactt tcgccgatta 955201 tttggagatt attaaagaaa atccgatggt cgcgcaatct gctcattctc gagtttttaa 955261 tatgataaaa gacagcggga tagaggagat tgacggacgc aagaagtaca gtttttttga 955321 ccgcgagctg ttcgggcttg aagaatctct ggagcgtctt gtggaagagt attttcatcc 955381 ggctgccaaa cgtctagatg tcagaaagcg gattctattg ctgatggggc ctgtgagcgg 955441 cggtaaatcc acgctggtca caatgcttaa aaaaggtctc gaagcgtaca cgctgacaga 955501 taatggcgct gtatatgcga ttaaaggctg cccgatgcac gaggaccctc tacatttaat 955561 cccccatcat ttacgcgatg acttttacag agaatacggc attagaatag aaggaagtct 955621 ttctccttta aatgtcatga ggctggagga agagtacgga ggaagaattg aggatgtgaa 955681 ggtggagcgc atcttctttt cagaagataa gcgtacggga attggaacat tcagtccctc 955741 tgatccgaaa tctcaggata ttgccgattt gacggggagt attgatttct caacaatcgc 955801 cgagtacggt tcagaatcag atccgcgcgc ttatcgattt gacggagagc tgaataaagc 955861 gaaccgcggg atgatggagt ttcaggagat gctgaaatgt gatgagaaat ttctctggca 955921 tttgctttcc ttgacacagg aagggaattt taaagctggg cggtttgcgt taatttctgc 955981 tgatgagctg atcgtggctc acacgaatga aacggagtat cgctcattta tttctaataa 956041 gaagaatgaa gccctgcact caagaatcat cgtgatgccg gttccttata atttaaaagt 956101 gtctgaggaa gagagaattt atgaaaaaat gattgcagaa agcgatgtgg cggatgttca 956161 tattgccccg catacgttga aggtcgccgc gatgttctca atccttaccc ggttaaaaga 956221 gccgaagcgg tcggatattg atctggtcaa gaaaatgaga ctgtatgatg gggaaagtgt 956281 ggaaggatat aactctgtcg acgttgagga tatgaaaaaa gaatataatg atgaaggcat 956341 gagcggaatt gatccgcggt acgtgatcaa ccggatttct tcaacgatta tcagaaaaaa 956401 tatggaatcg attaattctc tcgatgtcct tcgctcctta aaagaaggtc ttgatcagca 956461 cccatcaatt tcaagcgagg acagggagcg gtatttgaat tttatctctg ccgcccgcaa 956521 ggaatatgac gatattgcga aaaaggaagt tcaaaaagcg tttgtttatt catatgaaga 956581 atcagcaaaa acacttatgg acaattacct cgataacgta gaggcctatt gcaataaaaa 956641 caagcttcgt gatcctttga caggagagga aatgaaccct gacgaaaagc tgatgagatc 956701 catcgaagag cagatcggca tttcggaaaa cgccaaaaaa gcgttccgcg aagaaatttt 956761 aatccgcatc tcggcctatg cgagaaaagg caagcggttt gattacaatt cccatgaaag 956821 actgcgtgaa gctattcaga aaaagctgtt tgctgatctg aaggatgtcg ttaaaattac 956881 gacctcaaca aaaacgccgg atgagcagca gctgaaaaag gtaaatgaag tcgtggcccg 956941 tttaattgat gagcacggct acaactcgac gagcgccaat gagctgctga aatatgtcgg 957001 cagcctgctg aaccgataag caacgtgacc cgtccgaata gggcgggtta ttttgtccca 957061 ttttctaaat agtttgtcaa ttaaacgtgc atatgtgcat atgatgaata taaatctttt 957121 caaaagactt gtttcataat ctggcacaag ccggaatacg tatgtatcac gaccacaaat 957181 ggttaaggag gggaattcat gtcccaaaat gacagcggcc attttttgat ttctgaggaa 957241 aactggtccc tccatcgcaa aggcttcgat gaccagcagc gccaccagaa aaaagtgcag 957301 gaagcgatca aaaacaatct tccggacctc gtaactgagg aaagcattat tatgtctaat 957361 ggaaaagatg tagtgaagat cccaatccgt tcacttgatg agtataaaat ccgttataac 957421 tatgataaaa ataaacatgt agggcaagga gacggcgaga gccaggttgg agatgttgtg 957481 gcccgggatg gatcagacaa aaaacaaggg cctggaaaag ggcagggtgc cggtgatcag 957541 gcaggcgagg attattatga agcggaagtt tcattaatgg atttagaaga agcgcttttt 957601 aaagaattag agcttccgaa tctccagcaa aaagagcggg acaatatcat tcatacagat 957661 atcgagttta atgatatccg taaaacaggg ttaaccggta atattgataa gaaaagaacg 957721 atgatgtcag cctttaaacg aaacgcaatg tcaggaaaac cgtcgttcta cccaatttat 957781 ccggaggacc tgaaatataa gacgtggaat gacatcacaa agcccgaatc aaaagccgtc 957841 gttttagcca tgatggatac aagcggcagt atgggggttt gggaaaaata catggccaga 957901 agcttctttt tctggatgac ccgttttttg cggacaaaat acgagactgt ggaaattgaa 957961 tttattgccc atcatacaga agcaagagtg gtctcggagg aggatttttt ctcaaaggga 958021 gaaagcggcg gaacaatttg ttcttccgta tatcggaagt cgcttgagct tattgatgaa 958081 aagtacaatc ccgcccgcta taacatttac ccgtttcatt tttctgacgg tgacaacctg 958141 acatctgata acgcgcgctg tgtgaagctg gtcaatgata ttatgaagaa ggccaatctg 958201 ttttgctacg gcgaggtcaa tcagtacaac aggcattcaa cgttaatgtc tgcatataaa 958261 aatgtaaaag atgagaaatt taagtactat attttaaaac agaaatctga tgtttttcag 958321 gctctaaaga actttttcag aaatgaagag tctggtgtaa gccatcaatt ttcgtaatga 958381 aaagcccatt tcagggcttt tttttattta ataaaagcaa gaaaacgctt gcgaaaaaaa 958441 tacgggagaa aaagaaattt ttcctttgac aaatcttctt tcatttatta atattttatc 958501 ttgtgaacta ttattgagga atgaggtgaa aaggagttga ctgaatcaga acgtgctttg 958561 ctcacttttg aacagctctt cgatacgtct cgggcgatat ataaaaaaca gaagaagata 958621 ttggagattg tgcttgagcc ttttgatatt acagtccttc aatatttgct gatgtttaaa 958681 attcatcaaa gcggaagcac cccgctaagc aagctggcaa tgtcgcttga tcttaagcct 958741 gcttctgtga cgcggatgac agatattctg tataagcgcc aattgatgaa tcgatatgac 958801 agtccggatg accgccgtat cgtcatgatt cagttaaccg aagaggggga agaactgata 958861 gaaaaagccg ctgtgcaata tgcaaaaatg ggtgctggct tgtaccaaaa gcttgatacc 958921 tcccagctgc agtatttgcg caaactagcc ggaagtttaa cgaagcttgc tgaaggctgt 958981 tcagaaaaaa gcggtaatta aaaacttctc acatattttc accagctttc cgcaaaatga 959041 tagaggatga aacgaaagga gaaaacaaaa tgaacagagg acgtttaatt ctgaccaaca 959101 ttatcggttt gattgttgtt cttgcaatta tagctggagg tgcttactac tattatcaaa 959161 gcacaaacta cgtaaaaaca gatgaagcaa aagtagcggg cgatatggct gctattactg 959221 ctccagcagc aggtaaagta tctgactggg atctggacga aggaaaaaca gtgaaaaaag 959281 gcgacacagt tgcaaaaatc aaaggtgaac aaactgttga cgtaaaatcc attatggatg 959341 gcacaattgt gaaaaacgaa gtgaaaaacg gacaaaccgt acaagctggt acaacaattg 959401 cacaaacgat tgacatggac aacctataca tcacagcaaa tattaaagaa acagatattg 959461 cggatattga agtaggaaat agtgtagacg tagtagttga cggagaccct gatactacat 959521 ttgacggtac tgtagaagaa attggttatg cgactaactc aacttttgat atgcttcctt 959581 ctacaaattc aagcggaaac tacacaaaag taacacaaaa agttcctgtg aaaatttcaa 959641 tcaaaaaccc atctgataag gtgcttcctg gaatgaatgc atctgttaaa atttctgagt 959701 aaaacagatc agtcatcaaa ccatgaaagg aggttgtctt agatggctac aggcaaagaa 959761 aaaaatgcaa aaaaccctat gtcattgctg attgtgctaa tggcgggttt atttttggca 959821 attctaaacc aaacactgct taatgttgca atgccgcact taatgactga atttggcgta 959881 agtgcaacga cgattcagtg gctgacaaca ggttacatgc ttgttaacgg tgtattgatt 959941 ccgttatctg ctttcctgat tacacgattt ggccagcgga gtctctttct cgtcgcgatg 960001 ttttgtttta cgctcggtac gttagtctgc ggtatcgcac ctaacttctc tacaatgctg 960061 atcggccgtt tgattcaggc cgtgggcgga ggtatcttgc agccgctcgt tatgacaacc 960121 attctgttaa ttttcccgcc tgaaagcagg gggaaaggaa tggggatttt cgggctagcg 960181 atgatgtttg ctccagcggt cggcccgact ctttccgggt ggattattga gcattataca 960241 tggcgcatta tgttttacgg acttgtgccg atcggcgcaa ttgttatcat tgtggctttc 960301 ttcatcttta aaaatatggt ggagccgcaa aaaatcaaac tcgatactct tggcgcaatc 960361 ctctcgattg tcggattcgc ctccttatta tacggagtca gtgaagccgg atctgacggc 960421 tggaccgacc cgattgtatt gtctacagtt attatcggag ccattgcaat tgttgctttt 960481 gttgttcagc aattgcgtca tgatgatccg atgcttgatt tcagagtgtt taaatatgac 960541 attttctcac tctcgagtgt cattaatatc attattacag tggcacttta cactggtatg 960601 ttccttttac cgatttatct gcaaaacctg gtcggcttta cggcgcttca atccggtctg 960661 cttctgcttc cgggtgcgat cgttatgctg attatgtcac cgatctcagg tattttgttc 960721 gataaattcg gaccgagacc gcttgcgatt atcgggcttc tcgtgacagt ggtaacaacg 960781 tatcaataca cgcaattgac aattgataca ccatatacac acatcatgct gatctattca 960841 attcgtgcat ttggtatgtc tctcttaatg atgccagtca tgacagccgg gatgaaccag 960901 cttcctgccc gtctgaacag ccacggaacg gcgatgagta acacgcttcg ccaaatcagc 960961 ggatcaatcg gaacaagttt aattacgacg atttatacaa accggacgac attccattat 961021 tcacaaattg cagataaaac aagcacggcg gacccgaact tcctccatgc gttccaaaat 961081 gcagtttcga atttaatggt gaatatgaat gtgtcttatg atacggcgaa aacatatgtg 961141 tactcacata tttataaaca cgcatcactc gattccaatg tcatggggat aaatgatgcc 961201 tttatgtggg caaccttatt ctgtgtagca ggtttgattt taagtatctt cctgcgtgac 961261 gtcagaaaag ataaattgcg taagaagaaa aaagaggagc tttcattact tcctgctcca 961321 aaagaagcta aggaatctta atctgtacag ggaggtttcc tgaatgaaaa tttatgtagt 961381 gtatgatagt gaaggcgaac atactaaagt gcttgcagaa gcgattgctg aaggcgcgag 961441 agaaaacgac gcggctgaag tgttcatcga ccatgtagat caggctgata tccgcaagct 961501 taaagatatg gatgcgatta tttggggatg cccagggcat ttcggaacaa tcagctccgg 961561 tcttaaaact tggatcgaca gacttggcta cttgtgggct gaaggcgagc tgatcaacaa 961621 agtcggtgct gtcttctgca caacggcaac aacacacggc ggcttggaaa tgacaatgca 961681 caatttaatc acgccgatgt tccaccaagg catgattgtt gtcggactgc ctggcaacgt 961741 gcctgaaaac gcactttatg gctcttatta cggagcaggt gtcacttgtc cggtagacag 961801 tgatgagtta atgtctgagg aaggtattca gcttggacgc gcgttgggaa gacgtgtcag 961861 ccaagtcaca ggaaacctaa cagcaggaca gtaaggagag gttgaaatgg ccattattat 961921 agcaataatt gctgctgtca ttgtcattgc ggcccttatt acatttaacg tccgcaacgc 961981 ctcacctgga cctgagaagc aagaagcaac cgatagaatc gcacctccag aagaggaaaa 962041 aaacgaagcg cattaccctg ctgaagcaag ggctgccgag catacgccat ccgttgtcaa 962101 aaacgattct ccaaaagaga agcgtgacac aatgggtgat gatatttaca ggcaggcgct 962161 gcaaaagttt aagcattctg atgaagttca tgcagaagaa gaggtcactg aggaaagtga 962221 caaaatgcag gaccgcagct atcgtgatgc gctgctctct atgaaaaata agaaaaagta 962281 atgaaaaagg caaatccgtt tactcatgcg ggtttgcctt ttttgctgtt tccatcaatt 962341 atgtttttat caaataaatc catggaatat gttgtattcc accttgatct agtgtactat 962401 gttactcata caccgaggat tttttccggg aggtaaagac atgaattctt ttttaggttt 962461 attaaagaaa gatatcaagc tttcaagaat gtggctgcta gtatggatat gcggaatcat 962521 tttcttattg ggaacaggcc atattatagc ttctcgcacg aaagaacctc tagtcatttt 962581 tggttttttt gttgcagttg ctttttttct gcttttctta tctcctgttt ttgtttttta 962641 tcaccttcgc aaggaaggga aatcacagct ttggctgtac aatccaaatg gcggcttatg 962701 gctgttttct tctaaattgg cagcatcttt gctctatcaa tttgtgattc agttggcatt 962761 aacagcctat ggcatatgga tgtatcatat gctctctgta aaaaatctgc tggagcatca 962821 agttgatata acgagtacag tggctttgct gaatatgtat gggcttattt cttcgttaga 962881 tatgtcagta acagtcattg tgttttggac tgtttttcac tctctcagaa attggcgcgg 962941 aatgcggtgg gctgcgatgg ttctgttggt cgcaatgtgg ttattcttcg atgaatacat 963001 cataagccct ttggttgaat ctcaaaagca tttctggcct gtaacagtct attgcaattt 963061 tgatttccac ttccacaatg tttggagatt ggaactaaaa cctatccatc tgtctgtgct 963121 agggtttcct attgctatag tcatcacatt cttgctgctc atcatggctt caaaactgct 963181 tgatcgtaaa gtagaggtgt aaatatggac aatcaattcc aatcctcgaa accgatttat 963241 ctgcagatcg ctgatcagat cttttatagg ctggtcagga aggagctgct cccaggagac 963301 aagcttcctt cagtaagaga aatggcgatt caaactaaag taaatcccaa tacaattcaa 963361 agaacttaca gtgagatgga aaggctgggt attgtggaga caagaagagg tcaagggacg 963421 tttattgcgg aaaaagcaga aatcgtagac gagctgaaag acaagctgac acgagaggtg 963481 ctggaaggct ttgtcaagca aatgaaagag ctggggctaa cgaaagaaga aatgttagaa 963541 gggattaaaa cattcacaga gggaggctaa aatggaaatc aagctagaac atgtatcaaa 963601 aaaatacggc cgccatacgg ccgtcaatga tgtgtcaatc accctatcat ccggacggat 963661 ttatggcctg attggaccga acggcagcgg caagtcaacg accctgaaaa tgatggctgg 963721 ccttctgttt ccgacttcag gatttgtaaa agttgatgaa gagcaggtta cgagagaaat 963781 ggtgcgtcaa acggcttatc ttactgagct tgatatgttt tatccgcatt tcactgttaa 963841 agatatggtg aatttttatc agtcgcagtt tcctgatttt catacagaac aggtttataa 963901 gctattgaat gagatgcagc tgaatccgga aaaaaagatc aaaaagctat caaaaggaaa 963961 tcggggcagg ctgaaaatcg ttcttgcttt agcgagacgg gcagacgtca tcttgcttga 964021 tgaacctttt tccgggcttg atccgatggt cagggattcc atcgtaaaca gccttgtgtc 964081 gtacattgat tttgagcagc agattgtcgt gatcgcgaca catgaaattg atgaaattga 964141 gactttgtta gatgaagtaa tcatcctcgc caatggagaa aaagttgcgc agcgtgaagt 964201 agaagatatt cgtgaacagg aaggcatgtc tgttttgcaa tggtttaaat caaaaatgga 964261 agtttgctag aaagaggagg aatatgatga aaacagtgtt ggaattgaaa aacgtgacta 964321 aaaacatcag aggccgaacg atcattgatg atctcagttt tacgattcgt gaaggcgagg 964381 tattcggttt tttaggacca aacggagcgg ggaaaacgac aaccatccgg atgatggtgg 964441 ggttaatgaa gctgtcgaaa ggtgatgtcc tcatttgcgg ccaatcaatt acgaaagaat 964501 atgccaaggc gattaagcat atcggagcga tcgttgagaa tcccgagctg tataaatttt 964561 tgagcggata taaaaatctc cagcaattcg caaggatggt caagggtgtc acgaaggaaa 964621 aaattgatga agttgttgaa ctggtcggtt taacagacag aatccacgac aaggtgaaaa 964681 catattctct ggggatgaga cagcgtcttg gcttggcaca atgccttctg cacgatccga 964741 aagtgctgat tttggatgaa ccgacaaacg gccttgatcc ggcggggatc agagaaatca 964801 gagatcattt aaagaagctg acccgagaaa gaggaatggc tgtcatcgtt tcaagccacc 964861 tgctgtcaga aatggaactg atgtgtgatc gaattgcgat tctgcaaaaa ggaaagctga 964921 tcgatattca aaatgtaaaa gatgaaaaca ttgatgagaa tgatacatat ttcttccagg 964981 ttgagcagcc gagtgaagcc gctactgttt taaatcagta cgatttgctg agtaagacaa 965041 atggtgtaga aatcaaactg gctaaagagg aagtccctgc ggttattgaa ttgctggtga 965101 tgcagcaaat ccgtatttat gaggtcaagg tcataacaaa atcattagag gaccgtttct 965161 tagaaatgac aggtgaaaca aaagaggagg ttcagcatgc ttaatttgat ttataatgag 965221 tggctcaaaa ttttcagccg tgccggaaca tgggtgatga tcggaattct ggggctgaca 965281 atggttggat ttgcattttt ggcgaatcat ttttctgccg gtgaatcaaa ttcccattgg 965341 aaacaagagc ttcaagcaca aaacgccgaa ttaaagaaag aaatcaaaga agatccttca 965401 ctgaaagatg ggtataaaga aacaatcaca ctcaatgact atcgcatcga gcataatatc 965461 cctagtgaca cgggctatac ggtatggtct tatgtaacgg attcagcaaa ctttaccatc 965521 cttaccggtc tgtttactat tatcatcgcg gccggaattg tcgcgaacga atttaattgg 965581 ggaacgatta agctattaat gattcggccg ctcagtcgtt ttcaaatttt gatgtccaaa 965641 tatattacag ttctcctgtt tgggctcctg ttgctgttga ttttatttat cggttctact 965701 ttattagggt tgatcttctt cggaacgggt ggtgaaaccg ccgcgaatat tcatttaatc 965761 tataaggatg gccatgtcat tgagcaaaac atgatggggc atttggctac aacgtatctt 965821 tctgaatccg tctcggcttt aatggtggcg acgatggcgt ttatgctgtc tgcggtattc 965881 agaaacagct ctcttgcggt tggtttttcc atcttcttgt tggttgccgg tacgactgca 965941 actgcattta ttgcagcgaa atttgactgg gcaaagtata tattgtttgc taatgtcgac 966001 ttgactcagt atgtggatgg cacaccgtta ataaaaggga tgactatgac gttttctctc 966061 gtcatgctgg cgatctactt tatcatcttc ctgttgcttg ctttcggaat cttcatgaag 966121 cgggatattg caaactaata aaaaaagctg ttttgcttat gcaaaacagc ttttttgtca 966181 aaataaaaac tgcaggtttg cacctgcagt ttttcatatc aatttatgct tacgcttctt 966241 tagtaacgtt agcagcttgt ggtccgcggt ttccttcaac gatttcaaaa gaaacagctt 966301 ggccttcttc taaagttttg aagccttcgc cttgaatagc agagaaatga acgaatacat 966361 cgtcttgacc ttctacttcg atgaatccga aacctttttc agagttgaac cattttactt 966421 taccttctaa catgaaattt cctcctaaag cgatcataac gcttaaattc actattcttg 966481 ctcttaacaa actttcaaga cgaaaactct tacaaaactt tcttcttaaa gatagttcga 966541 acaaaaataa ttacctttac tctaccagta atcttcagaa aaaacaactg cttattgaaa 966601 tttttttcgg aaaataccat atttattttt caatttgata tttatttacg gaaattcatc 966661 tgttttctcg atatgtgatc atacgtttgc cttagtattc cttcattttg ggaagataag 966721 taataggaat tgacaacctt attggatatg agtaaggtaa aagttaatca atattacaaa 966781 tgacaacgtt tatcaactaa gagagcgtat gatttttatg tctgatattg cttgcatgct 966841 ctaatacata gataggagta tggtcacaat gaaaaagtgg cttatatgca gtttcgtcct 966901 tgttcttctc gtttcattta ctgcatgttc accgtctgca gaacatgaat cgataaaaat 966961 cgggattgct gagtctgacg gggcaatatg gaactatatt gctcaaaagg ctgaagaggc 967021 agggctggat attcagctga tccctttttc tgattatgcg gagtctgata tcgcacttgc 967081 taacaaagaa attgatgcca acgcctttca aaccatttca tattttcagt cgttcactga 967141 aaaatacaaa cttaatttgg caccgctcgg gacgacatac ataacgccca tgggcattta 967201 ttcaaaacga tatgaacgaa tccgagatat atcgcgggga gctgtcgttt ctgttccgga 967261 taaagcgttc gattttggca gggcgcttac ggtgctccag gaagcgggtt tgctaacgct 967321 gaaaaacgga tttaacggaa caggttcagt tgatatgatt aaagataatc cgagacacct 967381 gaaattaaaa gctgtccggc aacaggatgc agtgagcggt gccgacgtgt ttgtcatgaa 967441 accatcagaa gcaaaaaaag cgggcttgaa cccgaaaaag catacgctaa agagcggcgg 967501 actcatgtct gaggaagaga tgaatttgat tgttgtcaga gcggaggatc aagatcggga 967561 agcgctgcaa accattcttg agctttatca agctgatgat acagcggcat ttatagaaaa 967621 agaatatcag ggagatcttg tcccggcttt tctgcctttg aaacgtcttt cagattggaa 967681 gaatgaattc gaacattgaa ttcattcttt tttttctgaa aaacacactc tgttccgtcc 967741 cgtttctttc gctttgtaaa gcatttgatc ggcaagaatg ggcaaggatc ctggctgttc 967801 cgtattattg gggtaatgag cggcccctag tgatatcgta actgaaagct cgtcgccgtt 967861 tgttaataca atcggtgcat cacttacagt gctcctgatc cgttcagcga tccgggctgc 967921 tttatcaaga gaacagttcg gcaggagcac ggcaaattct tcaccgccga tccgagcggc 967981 aggatcagta tttcggatgg tctgcttcag acgtaaccct agctctttga gcacctgatc 968041 tccttcatga tggccatatt ggtcattgat ggtcttaaaa tgatcgatat ccatataaat 968101 cagtgcaaat tgaaaatgcg gggtatcggc cgcctgctga tacagagctt ttgtggtttc 968161 ttcaaatttt cttcggttat acacgcctgt taaaaagtca aagtgcgcct gaaacttata 968221 ttgtttaaaa agaagatgtg catttgtttc atgatcaata atatataaac tgagcatgcc 968281 gcccgctatt gatatgatcc aaaaatacaa atgaagttcg tatgaatgta aatctataag 968341 aaaataaaag gaaaaggaga tcaagctatt tgtgattatt aaaagataga aagcatgttt 968401 tagttgaact ttttttcttc tagaaacaat gagtgacgga atggcagcga tacaaatgat 968461 aataaccgag tatagtgcag atgtgttcat cgtaatcagc aagcggcctg cagtgatcat 968521 ggccagggcc gttgccgttg aaacccagcc tccataaaga gcggcaatca taatagggat 968581 atttcgaaga tcaataattg aatgctgata ggtaaatcca aaaaccatca gaataacccc 968641 gagcaaaccg caggccagtc ctttaacagc ttgaaaggat atgctgtctt ttttatgtac 968701 tagcctttct ttaaacaggt gggtgaagag ataattaaat gtgattaaaa tggtcaaatt 968761 tacaaacagt tctttcagca aatattatca cccttatata aggtactaaa gatggaaggg 968821 aaagaaaaga acaaaaaagg cattatataa ggttttttta cttgaattga taagttaaaa 968881 taattcgcac ttgacccatc ggaattagtg taatatagta aatgagaaaa tttgaaggga 968941 gagtttacct gctttggaga ctttactggt tgtattacat gtatttattt tatttttact 969001 tatcttaggg ctctttgtta tgcagaaaaa acatgtttcc ttctctaaac gtgtatttac 969061 tgcgctgggg ctggggattg tattcggatt tgcgcttcag ctgatttacg gcccgacttc 969121 aaatatagtc attcaaacag ccgactggtt taatattgcc gggggcggat atgtcaaatt 969181 gcttcagatg gttgtcatgc cgctcgtctt tatttcgatt ctcggcgcct ttacaaagct 969241 gaagctgaca aaaaatcttg ggaaaatcag cggtttgatt atcgggattt tagtagcaac 969301 aacagcagtt gctgcagctg tcggtatcgc gtccgcgctt tcatttgatc tgcaggcgat 969361 tcaggttgac caaggaagta cagagctttc acggggacag gagcttcagc agaaatcaga 969421 ggatatgaca gcgaaaacgc tgccgcagca gattgttgaa ctgctgcctg gaaacccgtt 969481 tttagatttt acgggagcta gaccgacttc aacgatcgct gtcgttattt ttgccgcttt 969541 ccttggagtg gcattcctcg gcgtaaaaca caaacagccg gaacaggcag aaacatttaa 969601 aaaactggtt gatgccgttt atgccattgt catgcgtgtt gtcacactca ttttgagact 969661 gacgccttat ggggtgctgg ccatcatgac aaaaacaatt gcaacgagtg atcttgacag 969721 cattctaaaa ctgggcatgt tcgtgattgc atcatatgcc gcgttaatca ctatgtttat 969781 cattcatttg ctgctgctga cgttcagcgg cttgaatccg gtgatttatt tgaaaaaagc 969841 ggtgcctgta cttgtatttg catttacgtc aaggtctagc gcaggtgctt taccgctgaa 969901 tattaaaaca cagagaagca tgggtgtacc ggagggaatc gcaaactttg ccggttcgtt 969961 cggtctttcg atcggccaaa atggatgtgc cggcatttat cctgcgatgc tggcgatgat 970021 gattgctccg actgtcggcc aaaatccatt tgacccggtg tttattatca ctgttatcgc 970081 agtcgttgcc atcagctcct tcggggttgc cggagtcggc ggcggagcga cattcgcggc 970141 gcttcttgtt ttatcatcat taaacatgcc tgtcgcgctc gccggtttgt taatctcaat 970201 tgaaccgtta atcgacatgg ggcgtactgc tttgaatgtc agcggaagca tgacatccgg 970261 tcttattaca agtaaggtca caaaagaaat tgatcaaggg gcatttcatg atcaatccag 970321 agtgattgaa gctgaagaag cgtaacatat gaaaacgtgt aatccaagag gattacacgt 970381 ttttttaacg gccaggctct aagtcctcca gcatttccat catcgtgttg tcgtccatga 970441 cattcattgc gttttgttca aaatgaatgg gttcagcata atgcggctgt ctttttttcg 970501 cggctgtctc agtttgccta gtttgagact gtgtatgctg atgctgtggt tgctgctgtc 970561 cagcgtgctg gtgctgacgg ccattttgcc gctggctttg atgctgcgaa cggtcctggt 970621 tatcaccgct gcttccgctg cttccgctaa atgcttgttt gaccatgttt cctacattag 970681 aagcatcaaa cgtgttattt tctgaatttc gtctgttcat ttgtcctgtg ataaacccgc 970741 tgattctttg gcggatctga ggtgataatg cagtaataag catagttgat cctatgatca 970801 atgctgcggg gctgattcct cttcgctggt tgaacaacat gatccctcct ttgcagtgta 970861 ttcatatttt ccccctcgtt agacaaatta accgttatat ttcccgggaa agcatttcct 970921 ccagatttgc atgcataatt aaagccagtt agaaaaacct ataagtaaag tgataaagga 970981 ggaattcaca tgtttggaaa aaaacaagtc cttgcgtctg tgcttcttat ccctttgctt 971041 atgactggct gcggtgtagc cgaccaaggt gagggcagac gtgataataa tgatgtaaga 971101 aacgtaaatt atcgaaatcc ggccaatgac gatatgcgga atgtaaacaa tcgggataac 971161 gttgacaaca atgttaatga taatgtcaat aacaatcgtg taaatgacga taataacaac 971221 gaccgaaaac ttgaggttgc tgatgaagca gctgataaag taacagacct aaaagaagta 971281 aagcatgccg atatcattgt ggctggaaat caagcctacg ttgcagtcgt tttaaccaat 971341 ggaaataaag gtgcagtaga aaacaatctg aagaaaaaaa tagccaaaaa ggtaagatct 971401 actgacaaaa acattgataa tgtttacgtt tcagctaacc ctgattttgt agagcgtatg 971461 caaggatatg gaaagcgtat tcaaaatggt gacccaatcg ccggattatt tgatgaattt 971521 acacaaactg tacagcgtgt attccctaac gctgaataaa tgaaagaagc cgcacaattt 971581 gtgcggcttt ttctttgcgt taatgacaca ctgcgaactc aggctgcata gagtaaaaat 971641 aaaaaggtac aagacggacc ggctcaggga gggagacgtt tgcgggatgg cataggaaag 971701 cgtgcggcat ccgctctatt cctgtgcgga gtccttgtga tgctggctgt aagctcagcc 971761 atcgtatcaa gcgcgatgta tatcctgtct tttccaggtc aggcatctgg aataacaaaa 971821 gaacaagtga cgaagcacat gaagaaagag tcattcaaac aggccgatat ttattacact 971881 tctaaggaaa agtccttact gccattgacg aaagaaacgc ttgaatatgc ggtcagtatt 971941 aatcagatta tgattggata ttcgaatcaa aagcctattg acattatttt ttttcctaat 972001 gaaaaacaga tggaggctta ctccggttta ttggatgtag ttggttttta ttctgaacgg 972061 gagcagctga tcggattgtt gcctgaagag aaaaagaaac tgttagaagg ggacgaggta 972121 gcggtttatt tgtaccagag attgttgatt catgaatact cgcaccatgc gtttcaccag 972181 aaattgaagg agcttgagac ggatcccgat gagtttccgt tatggtttca tgaagggtta 972241 agcgagtgga ttgcgaacta tgaattgctc atagatccga tcacgttttc tgtcgtgccc 972301 tttgaccgtt tgcagactga tcgagactgg caggaagcta gagccgaata tgacactgat 972361 gtctatttgc aaagctttta tatgatcgat gagctgacgg acaaatacgg gaaagacatt 972421 atttcagaaa tgattaagga aacggcaaaa aaaggggact ttgaaaaagg gtttaaatca 972481 gcaacaaagg aaagtcttga tcaatttgaa aaagatttta agaaaaaatt tgaaaaaaac 972541 agtgcggcat tggatagtat ctatccaatg cctttgttat tagtgaagtc cttgctgacc 972601 cattccgcct tgtgtcggag gcatttgtcc ttgggcaggg gcgaatgaat ttcgcagctg 972661 ttccatatcc tgcgcatcaa gctgaggaac ctggtaatag ccgtgtttgt tttggtatag 972721 gaaaatttca aatgccattt caacatactc ctgaatttgc gcagacagta cgcgtcttac 972781 ggccggattt gtcatttcca gagaagccat cgtcagcata gaagcttgtg ctttaatcgc 972841 gcaaagcatt tgtcggctga tgatgctgtc atcaatatca ttcatggatt gaacaggttt 972901 tttaggctgt gacggctgca tgccgtaaac agtctggttg tcttccttca tcatataagt 972961 tgctgttttt tgtgaaggtt cgcttcctgt tttgaagcat tctgcagtta tattgtattg 973021 agatgtgatg aattgatgtt gacgatcaag gatgtttagt aattcttgat ccttacagaa 973081 ttgtctcagc atcataaact gatcaagcac agtaagtgtt ccggaaagca cctcatgcat 973141 atcaaacatt tcatgtccgc cgtggttttt atgcggtttg ccaggaatac ctttgttcat 973201 ttgggattgc tgctgctgat tgaactgatc caaaccgaat tcctcctttt ttttcagatc 973261 agctgtattt tgtgtcagtc tgccgtgtat tatgcagaag cctgaaagga attatatgct 973321 gtctgtcgaa atgataagca gacaaaatcg ttgtcattat gtgtataagg gaggaaatat 973381 gatgaggcgt attctgcata ttgtgttgat cacggcatta atgttcttaa atgtaatgta 973441 cacgttcgaa gctgtaaagg cagctgaacc gcaacagcct atatcgattg agaaggcaat 973501 acagcaaaaa gaaggacagg cacttgtcga aggatatgca gtcggccagg ctgtttcccc 973561 gcagcattat aaactgacaa gccctttttc aaatgattat aatgttgcgc tggcagaccg 973621 taaaaacaaa acatcgcccg aacacatcct tcctgtgcaa atcccctccg ccttcagaag 973681 ccaatttggg ctgcaaacca atccgcttct tcttgggaaa aagataacgg ttcaaggaaa 973741 gcttgaaaat tactttaaca cgacaggact taaaaacgtt cagtcgatga acgtaaccga 973801 tgacacaaaa actccgccgg ctgaacagca agtgaccata aatgaagcac ggggaaggct 973861 gaatgaagaa gtaacgataa aagggatcat tacagctgat caaaacgcaa tcggaggcgg 973921 gaagctgtcg acctttttgc aagatgaaac cggaggcatt aacatttatt cgccatcccc 973981 tgaacaattt cccgaattaa aagagggtat ggatgtcacg gtgacaggga aaatcacgtc 974041 ttaccagggg ctgaaagaaa tcgttccaaa ctcatcaggc atcaaaatca accagtcaaa 974101 tcaatccctc cccgccccca aacacttaac aatcaatgaa cttattaacg gcagcctagg 974161 tgatcagtat gaaggacgcc ttgtgaaact aaccgctttt gtttcctcaa ttccaagttc 974221 tcctgccggc ggcggttaca atgtaacaat gattgatgac gaccatcatg caatgacgct 974281 ccgggttatg aatgaaacag gggtgataaa cgagcttgat gagggcaaat ggtatgaatt 974341 taccggtgtg ttaagcagat accaaacctt tcagctgctt ccgcgaaaat cggctgacct 974401 gaagctgctt gaagagcagc ccgcacctcc gtctgcagag ggagaatatg aagggattgt 974461 tgaccgggta gttgacggcg ataccattca tcttaaatct ccggtgcttg gaacgacaaa 974521 aatccggttt gtaaatgtag atgcacccga aacatatcac acaccaaaaa atgacgcaga 974581 tgaaaatcaa ttaagatttg gcaaaaaagc atctgactat ctaaaaacgg ttctgtcccc 974641 gggtgataaa attactgtca aggtcgggag tgaagccaag gacagctatg gcagattgct 974701 cggacaagtc ataaccgaat caggttcaaa cgtgaactta gagcttgtaa aaaacggcta 974761 tgctccgacg tattttattt ggccggttga caatgaagag gattatcagc aatttcaggc 974821 cgcagtagcc gctgcaaaaa aagatcaaaa aggaatttgg aatgaaaacg atcccctcat 974881 ggaaatgccg tttgaattca gagccagaga gcaagggaaa ggcctgacaa gatatgtggg 974941 ggactcgtcg aataaaacat atgtgcagcc agctgactgg aagaagatag ctgtggaaaa 975001 cagaattttc ttcgcctcag caagtgaagc ggagagcgcg ggatataaaa aaaggcaaac 975061 ggcacctcaa gaacatgtgc cgcttagaat tctcagcatg aatgatttgc atggcaaaat 975121 cgatcagcaa tatgagcttg atcttgatgg aaatggaact gtagacggca cgtttggacg 975181 catggattat gccgccgcat atttaaaaga aaaaaaggct gaaaagaaaa actcgctgat 975241 tgtgcacgcg ggagatatga tcggcggaag ctctccagtt tcctctcttc ttcaggatga 975301 accgactgta gaactgatgg aggacatcgg atttgatgtc ggaaccgtgg gaaaccacga 975361 atttgatgaa ggcacggatg aacttctgag gatcttaaat ggcggtgatc atccgaaagg 975421 cacaagcgga tatgatggac agaactttcc ccttgtatgt gccaattgta aaatgaaatc 975481 aactggagag ccctttttgc cggcttacga catcattaat gtggagggcg tacccgttgc 975541 ttttatcgga gttgtcacac agtcggcagc tggcatggtt atgcctgaag gaataaaaaa 975601 tatcgagttt acagatgaag caacagcggt gaataaggcg gccgaagagc tcaagaaaaa 975661 aggcgtgaag gccatcgcgg ttctcgcaca tatgtcagct gaacaaaacg gcaacgccat 975721 taccggtgag tctgctgatc ttgcaaacaa aacagattct gaaattgacg tgatttttgc 975781 cgcgcataat catcaggttg ttaacggtga agtgaatgga aaactgattg ttcaagcgtt 975841 tgaatatgga aaagcgatag gtgtcgttga tgtagagatc gataaaacga caaaagacat 975901 tgtcaaaaag tccgcggaaa tcgtatatgt tgatcaaagt aaaatcgaac cggatgtcag 975961 cgcgtcagcc attttaaaga aatacgaaac aattgcggaa ccgattatca gcgaggtagt 976021 cggcgaagcc gctgttgata tggaaggggg gtattcaaat gacggcgata cacctcttgg 976081 aaacctgatt gcggatggta tgagagctgc catgaaaacg gattttgccc ttatgaatgg 976141 cggcggcata cgtgaagcgc tgaagaaggg tccaattacg tggggagatc tttacaatat 976201 tcagccgttt ggaaatgtgt taacgaagct tgagattaaa ggaaaagatt taagagagat 976261 tatcaatgcg caaatctcgc cggtttttgg gcctgactac agcatcagcg ggtttacgta 976321 tacgtgggat aaagaaaccg gaaaagcagt tgatatgaaa atggcagatg gcaccgagat 976381 ccagcccgat gccacatata cattgaccgt caacaacttt atggcgacgg cgacaggagc 976441 caaatatcag ccaatcggac tgctgggaaa aaatccggtg acagggcctg aggatttgga 976501 agcgacagtt gagtacgtga agagttttga tgagccaatt gcgtatacaa aagagggaag 976561 aattaagctt gctgaagcca gtgatattga agaccctgta acagaagacc cgataacgga 976621 agagcctgga gatgatccgg ggacggagga tccgattaaa gaggatccaa ggccaggtga 976681 agatttgcct gatataaaag aaactccggg aacagcaccg gttcatcagc ttccgccttc 976741 agccatttcg agattcaatg aaataccaat caacaacaca aaaaccgctg atactgctaa 976801 tagcatcagc acattgccgt tacaaaccga gactgcggaa agcgggtctg atcatcagct 976861 tccggatacg tcagcgggct actataactt tatggtaatc ggtgcggcgg tgacattgtc 976921 aggaacttat ctatatgtca gaagaaaaag gagcgcctcc agaacgtgaa aaaagttatt 976981 ccactattca tcattgctgc cggcctagtg atcgcaggct atggaggctt taaattgatc 977041 gatacgaata cgaaaacgga acagacatta aaagaagcaa agctggcggc taaaaagccg 977101 caggaagctt cggggacgaa aaatagcaca gatcaagcaa agaacaaagc atcatttaag 977161 cctgagaccg gccaagcgag cggcatttta gaaataccga aaatcaatgc agagcttccg 977221 atcgtggagg gcaccgatgc tgatgattta gaaaaaggtg tcgggcatta caaggacagc 977281 tattatcctg atgaaaacgg acaaattgtg ctgtcagggc atcgggatac cgtgtttcgc 977341 cggacgggag agctggaaaa gggggatcag ctccgtcttc tcctgtcata tggagaattc 977401 acatatgaaa ttgtaaaaac aaaaattgtc gataaggatg acacatctat tatcacgctc 977461 cagcatgaaa aggaagagct gattctgacg acctgctatc cgttttcata cgtcggaaat 977521 gccccgaagc gctatattat atatggaaaa cgagtgactt aaaaagccga ggcagtgcct 977581 gcggcttttc ttcatgaaaa atatgtgcgg caaaggtttt tcatatcagc agggaaaggg 977641 gcttcagcaa ctatgagctc gtctgttatc gggtgaaccg cttgtacttt attggcgtgc 977701 agtgcctgcc tgtttagcag cttgctcccg cctccgtaaa gcgagtctcc tgtcaacgga 977761 tggccgaggc tcgccagatg aacacggatt tggtgtgttc tgcctgtttc cagctctaat 977821 tcaacgagcg acagccgttc tttcgcattg ctggccatta ccttgaaatg agtgacggct 977881 gtttgcccgc ctggtgaaac ccggcgtctt gtcgggtgtg agcggtctct gccgatcggt 977941 gaattaattg tccctttttt cgtccgtagc ttaccttcag cgatagcggt atacgtacgc 978001 ttcagcgtct ttttctctaa ctgctggtct aagatggcgt gtgccaaacg atgcttggca 978061 aaaacgatag cgccagatgt atcctgatca agacgatgga cgtggcgcac cttacatgtt 978121 tcgccattta tctgataatg atacgcgatc aaattagcca gtgtgccggt ttgcccatcc 978181 tcattcggat gcgtcgcgat gccagcgggt ttattgatga tgagcatatg attgtcctca 978241 aataaaatat caagctcgcc atactccgga atgaccgaag atgcttcact ttcctgaaga 978301 tcaatgaaca cgcggtctcc cttttttaca atcatattgt ttaagacgga ttcgtgattg 978361 acctttatct gttgatggga catccagtct tgtatcactg gtttagaagc tttgagcgct 978421 gttttgagta cggaaaacag ccattggccg tcctgttttt cattgatgag gatctcaagc 978481 cctctgcctt tttggttcat gttaaatggc tccttttcga agcggaaggc tgctgtttct 978541 cataggaaac acttacctta gctttcgcgt ttttttctgt gctattcttg agtaagactt 978601 aggatattcg atggcaagaa aggtgattga cgtgagaatt gtgaacgcag caactgcaga 978661 acaggagagc tttatcaagg agctgtctat ggagctgatc catgatgtat ttcctcttta 978721 tttctccgaa ctggacattc agcgctttaa aaagaaaggc gttctgtctt taaataacca 978781 ttattaccaa ggaacattaa aagaagcatt tcaaattatg gcttgtctgc aaatgataca 978841 tattatcctg accaagcctt cgccgcactc tgatttgagt gatcaggcga tttttgaaaa 978901 aaacagcaag atgctgaatg attttgggat ttattttccg tttgcttttt ctgactttca 978961 aaagaagact aacaaagcct ttttcggtca aagaaggctg atataatcat gcggcaaggg 979021 cttttctatt tttagaaaag ctctttttgt atcagagaaa tcatatcata aaacctttcc 979081 tctaactccc tttttaaacg gctcgtgtct gaacatacta atgattgaaa ggggtgctga 979141 caatgagttc agttaaagat acaatgacaa cgcaggtggc aaccgtttct ccgaatcaaa 979201 cgattcagga agcggcttct ctaatgaaac agcataacgt cggggcgatc cccgttgtag 979261 agcaaggtgt tttaaaagga atgctgactg accgtgacat tgcattaaga actacagctc 979321 agggccgtga tggccagaca cccgtttcag aagtgatgtc aacagaactc gtatcaggaa 979381 accctaatat gagtctggaa gacgcgtcgc agctgatggc ccagcaccaa atccgccgcc 979441 ttcctattgt agatcaaaac aatctagtcg ggatcgttgc gcttggagac ctggcagtca 979501 atcagatgtc gaacgagtct gcgggatcag cgctgacaaa catttctcac caaaacattc 979561 attaataaga aagagcttgc agtgtgcagg ctctttcttc acataaaacc ttactttttg 979621 aaagcagact tgtttcgggg tatagtgagt gtatacatat gtctcaattc gtactaaagg 979681 agttgtaccc agtgattaaa gcgttaattt ttgattttga cgggcttatt ctagatacag 979741 aaacacacga atatgaggtt cttcaggaaa tatttgaaga gcacggctca gtgctgccgc 979801 tatctgtctg gggaaaggtc atcggaactg ctgcgggttt ccggcctttt gaatatttag 979861 aagagcagat cgggaaaaag ctgaaccatg aagagctcac acaattgaga agagagcggt 979921 ttgccaaacg catggaatca gaaaaagcga gacctggtgt cgaagcgtat ttgaatgcgg 979981 caaaggattt aggcttaaaa ataggccttg cctccagctc tgattataaa tgggtgtccg 980041 gccatttgaa gcaaatcggc ctgtttgatg attttgaagt tattcaaacg gcggatgatg 980101 tggaagaggt gaagccgaat cctgaactct atttattggc ggcaaagaac ctgggggtat 980161 cgccagcgga atgtctcgcg tttgaggatt ctgtcaatgg ttcgattgct gcgaaacgtg 980221 caggcatgaa gtgtgtcatt gtcccgaata aagtaacggg taccttgatg tttgaagact 980281 atgatcacag gcttgaatca atggcggaga tggagctcgc cctattgctt gatcatctga 980341 actcacaaaa ctagaaagga gcgagtaggt tgtctgagaa attagatttg acccggtttg 980401 aaaagaaaat ggttatccgc aatatcgaag agaaagacat cgacaagatt atcgatcttc 980461 aaaaggactg ctttccagga atggagcctt ggaagcggga gcatttaatc agccatttgg 980521 agcattttcc ggaaggacag ttttgtgcag aattcgaagg tgaaattatc ggttcgtgct 980581 caagtctcct gattaacttt gatgaatatg atgaccgcca tacgtggcag gacattacag 980641 atgacggtta tatcaccaac cataatcctg acggcttgaa tatgtacgga attgaagtca 980701 tggtgcaccc gaaatacaga cgaatgaaga tcggccaccg tttgtacgag gcgagaaagg 980761 acttagccag acgcttaaac ctgaaaagca tcatcatagg cggacggatt ccaaactatc 980821 acaaatatgc agaggaaatg acagcgagag agtatgttga acaggtgaca cgccaccaaa 980881 tttacgatcc ggttctttct tttcagctga tgaacggctt tacccttatg cgaattaacc 980941 cgaactatct cccggatgat acagcttcga tcaagtatgc gacgctgatg gaatggaata 981001 atgtcgatta tctaccgcag cagacaaaac gctattataa atcggcgttc cctgttagaa 981061 tttgtgtgat ccaatacgaa atgaagaaaa tttattcctt tgaggaattt gcgaatcaag 981121 tagaatacta tgtcgatgtt gcttccgacg caagatctga ttttgcggtg ttcccggaaa 981181 ttttcacaac ccagctgatg tccttccttg aggaacggtc accgagcttg gcggtgcaga 981241 gaattaccga gtatacagaa gattacatca gcctgtttac tgacttggct gtgaagtata 981301 acgtcaacat tatcggcgga tctcatttcg tcgaagagga aggcaagatc tataatatcg 981361 cttacctgtt cagacgggac ggaacgatcg agaagcaata caaactccat attacgccga 981421 atgaacgcaa atggtggggg atcagcgcag gagaccaagt tcgcgtgttt gatacggact 981481 gcgggaaaat cgcgatccag atctgttatg acattgaatt tcctgagctt gcccggattg 981541 cggctgataa aggagccaaa atcatcttta cgccattttg tacagaagac cgtcaaggct 981601 atctgcgtgt cagatactgt tcgcaggcta gagcggttga aaatcaaatt tatacggtta 981661 tctctggaac ggtcggaaac cttccgcaaa cggaaaacat ggatatccaa tacgcccagt 981721 caggcatctt tgccccgtct gattttgaat tcgcccgaga cggcattgtc ggcgaaacaa 981781 acccgaatat tgaaatggtc gtcatcggcg atgttgacct ggaaattctc agaagacagc 981841 gccaaaacgg tacagtgcgc cagctaaaag acagacgacg tgatatttat catattcaat 981901 ataaaaaata attcccaaaa aacccgcctg aattggcggg tttttttaaa caaaagcgga 981961 attgtttagg tgctttcttt aaaataaaag taaattgtat agtggatgtg ccttatggag 982021 tttctgtatt ttcgccattt cctatatcat acagaaaacg gctaggcttc acattgctat 982081 tgcaatggct gtccaagttg tttcgagtgc gacctttatc agtacgatgc tgagcattgt 982141 cactttgcct gttttgcttt ggaagctgca tcctctttct tcttgagaaa ggggatgttt 982201 tattatttac gcggtttatt gactctgacc cggtctggct ttatattgaa ggcagggaaa 982261 tcatcaccaa gacatcacat aaagagaagg tctgtttcaa ttgaattggc attataggga 982321 acgctaatga aatggagatg atggggatgg aaaacattca gcaaaatcag ggattaaagc 982381 aaaaagatga gcaatttgtg tggcatgcca tgaagggagc gcatcaagcg gacagcctga 982441 tagcccagaa ggccgaaggg gcctgggtaa ccgacacaga cggacgccgc tatttggatg 982501 cgatgtccgg tttgtggtgc gtcaacattg gttacggcag aaaggagctt gcggaggctg 982561 cctatgagca actaaaggag ctgccttact acccgttaac gcaaagtcac gcacccgcaa 982621 ttcaactggc ggaaaagctg aatgaatggc ttggcggcga ttatgttatt tttttttcca 982681 acagcggatc ggaagcaaac gaaactgctt ttaaaattgc ccgccagtac catctgcaaa 982741 acggcgacca cagccgttat aaattcatct caagatatcg ggcataccac ggcaatacat 982801 tgggagcgct ctcagctacc ggacaggcgc agcggaaata taaatacgag cctttgagcc 982861 aagggttcct gcatgcagct ccgccagata tataccggaa tcctgatgat gcagacacgc 982921 ttgaaagcgc aaatgaaatc gaccgcatca tgacatggga attaagcgaa acgattgccg 982981 gggtcattat ggagcccatc attacaggcg gaggcatcct aatgccgccg gacggatata 983041 tgaagaaggt ggaggacatt tgccggcgcc acggagccct tttgatttgc gatgaagtga 983101 tctgcgggtt tggacggaca ggtgagccgt tcgggtttat gcactacggt gtgaagcctg 983161 atatcattac gatggcaaag ggaatcacaa gcgcgtatct gccattgtca gcgactgctg 983221 tgaaacggga cattttcgaa gcgtatcagg gggaagctcc ttatgaccgt ttccgccacg 983281 tgaacacgtt cggcggaagc ccggctgcct gtgctttggc gttgaaaaac ctgcaaatta 983341 tggaggacga acagctgatt cagcgatccc gtgatcttgg agcaaagctt ttaggtgagc 983401 ttcaagctct gagagaacac ccggcagtcg gggatgttag aggaaaaggg ctgctgatcg 983461 gaatcgaact cgtcaaagac aaattgacta aagagccggc tgatgccgcc aaagtaaacc 983521 aagtggttgc ggcgtgcaaa gaaaaagggc tgatcatcgg caaaaacggc gatacagtcg 983581 ccggctacaa caatgtcatc cagcttgcgc cgccattttg cctgacagaa gaggaccttt 983641 cctttatcgt gaaaacggtg aaagaaagct ttcaaacgat ataatataaa agtgaattat 983701 taaaggagca catgatgagt tttcacaacc agccgatctt accggctatt cgcaatatga 983761 agcaatttga tgagtttttg aacagttcat tctcttacgg tgttattctt gatattcatc 983821 tcggccagct gaagggcgtg atcaaagaag cgcaaaagca cggaaagaac atgatggtgc 983881 acgtcgatct cattcaaggg attaagcatg acgaatacgg tgcggaattt atatgtcagg 983941 atatcaagcc cgctgggatt atttccacaa gatcgaatgt gattgccaaa gcgaagcaga 984001 agaaaattta tgccattcag cgcctgtttt tgcttgatac aagcgcgatg gagaaaagca 984061 tggagtttat cggcaagcat aagcctgact tcatcgaagt gcttcccggc atcgttccgt 984121 cactcattca ggaaataaaa gagaaaacag ggattcccat ctttgccggg ggtttcatcc 984181 gtacggaaga ggatgtagag caggcattga aagcgggggc tgtagctgtc acaacatcta 984241 ataccaaatt gtggaaaaaa tatgaaaact ttttgacgga aagtgattga caccgctttc 984301 atgcactgat acaattgcac taggttaata cattgtgatg gagaactcgg agaccacagc 984361 agctctttac ggcaaatgtt tatgcacccg taaagcggtt tgttgtggtt tttttattct 984421 cttcttctct atcatgcttt ttaatcgtga ctttaggagg aatgtgctat gacagcattt 984481 tggggagaag tcatcggtac gatgctgctt atcatttttg gtgcaggtgt ttgtgcaggt 984541 gtcaatttaa agaaatcgct ttcattccag tctggctgga ttgttgttgt atttggatgg 984601 ggattgggtg ttgccatggc ggcatacgcg gttggcggca tcagcggtgc ccatttgaat 984661 ccggcgctaa cgatagcgct tgcatttgta ggagattttc cttggaaaga ggttccggtt 984721 tatattgcgg cgcaaatgat cggagcgatc atcggtgcgg tgattattta tctgcattac 984781 ctcccgcact ggaagtcaac ggatgatccc gctgccaagc tgggtgtttt ctcaacaggg 984841 cccagcattc cgcatacatt tgcaaacgtt ttaagcgaag tgattgggac atttgtcctt 984901 gtacttggaa tcttggccat aggtgcaaat caatttacag aaggacttaa tcctttaatc 984961 gtcggtttcc tcattgtagc aatcggtatt tctctgggag gcaccaccgg ctatgctatc 985021 aatcctgcac gtgacttagg tccgcggatc gcccacgctt ttcttccgat tccggggaag 985081 ggctcatcaa actggaaata cgcatgggtt ccggtagtcg gcccgatttt aggcggatca 985141 ttcggcggtg tattttacaa cgctgcattt aaagggcaca tcacaagcag cttctggatt 985201 gtaagcgtta tattggttgt ggtattgtta ggactctatg tttatacgaa atcacattct 985261 gctaaaacat tatcaaattc taaatatatt taatcaaagg ggagacatct tatggaaacg 985321 tacattttat ccttagatca ggggacgaca agttcaagag cgattctgtt taataaagaa 985381 ggcaaaattg tccactctgc tcaaaaggaa tttacacaat acttcccgca tcctggctgg 985441 gttgagcata atgccaatga aatttggggc tctgtcctcg cggttatcgc ctcagtcatc 985501 tctgaatcag gaatcagcgc ttctcaaatt gccggcatcg gcatcacgaa ccagcgcgag 985561 acgacggttg tgtgggataa agatacagga agtcctgtct ataatgcaat cgtttggcag 985621 tccagacaga cgtccggcat ttgtgaggaa cttcgtgaaa aaggatataa tgataaattc 985681 agagaaaaaa cagggctttt aatcgatcct tacttctccg gcacgaaggt gaagtggatt 985741 ttagacaatg tggaaggcgc aagagaaaaa gcggaaaaag gcgagctgct gtttggaacg 985801 attgatacgt ggctcatttg gaaaatgtca ggcggaaaag cgcatgtgac cgattactcc 985861 aatgcctcaa gaacactgat gtttaatatt tacgatttaa aatgggacga tgaactgctc 985921 gacattctag gcgtaccgaa atccatgctc cctgaagtga agccgtcctc tcatgtgtat 985981 gcggagactg ttgattatca cttcttcgga aaaaatatcc cgattgctgg agcggcaggc 986041 gaccagcagt ccgcattgtt cggccaggca tgctttgaag aaggcatggg gaaaaacact 986101 tacggcacag gatgtttcat gctgatgaat accggggaaa aagcaattaa gtccgaacat 986161 gggcttttga caacaatcgc ttggggcatt gacggaaaag tgaactatgc gttagaaggg 986221 agcatttttg tcgcaggctc tgccatccag tggcttagag acggtttgag aatgttccag 986281 gattcatcgc taagcgaatc ttatgcagaa aaagtggatt caactgacgg cgtgtatgtt 986341 gttccagcat ttgtcggact gggaacgcct tactgggaca gcgatgtgcg cggttcggtt 986401 ttcggcctga caagagggac aacaaaagag cactttatcc gtgcgacact ggagtcattg 986461 gcttatcaga ccaaagatgt gcttgacgca atggaagcag attcaaacat ttcattaaag 986521 acgctccgtg tagacggagg agctgtaaaa aacaatttcc taatgcagtt ccaaggagac 986581 ctgttgaatg ttcctgtgga gcgcccggaa attaatgaaa cgactgcact tggcgcggct 986641 tatttggcgg gtatcgctgt gggattctgg aaggaccgtt ctgaaatcgc gaaccagtgg 986701 aatctggata aacggtttga gcctgaattg gaagaagaaa aacgaaatga gctgtataaa 986761 ggctggcaaa aagccgtgaa agcagctatg gcttttaaat aaagtaatac tatggtataa 986821 tggttacaag ttaataagaa cggtcctgag atgaggagag accacagcac caaagtgtaa 986881 gcatgcactt tggctgttgt ggtctctttt tctatttacc gtgacaacaa ggaggaaacg 986941 taatgatgaa tcatcaattt tcaagtcttg aaagagatcg catgctgaca gacatgacga 987001 aaaaaacata tgacctattt attatcggag gaggaattac aggagccgga acagctcttg 987061 acgcggcatc aaggggaatg aaggtcgcac taagcgaaat gcaggacttt gcggcgggaa 987121 catcaagccg atcaacgaag ctggtacatg gcggcttgcg ctatttaaaa caatttgaag 987181 tgaaaatggt cgctgaggta ggaaaagagc gggcgattgt gtatgaaaac ggcccgcatg 987241 tcactacacc ggaatggatg ctgcttccgt ttcataaagg cggcacattc ggttcattta 987301 caacatctat tgggttaagg gtttatgact tccttgcagg tgtgaaaaag tcagaacgaa 987361 gaagcatgct ttcagcaaaa gaaacgctgc aaaaagagcc tttggtgaaa aaagacggct 987421 taaaaggcgg cgggtactat gtggaatacc gcactgacga tgcgagactg accatcgaag 987481 tcatgaagga agcggttaaa ttcggggcag agcctgtgaa ttactccaaa gtgaaggagc 987541 ttctttacga aaaaggcaaa gccgtcggcg tattaattga agatgtgctg acaaagaaag 987601 aatataaagt gtatgcgaaa aaaattgtca atgctacagg cccttgggtc gatcagctca 987661 gagaaaaaga ccattcgaaa aacggaaagc atttgcagca tacaaaaggc attcaccttg 987721 tatttgacca gtctgtcttt ccgctgaaac aggctgtata tttcgataca cctgatggcc 987781 ggatggtatt tgcgattcct cgtgaaggca aaacatacgt gggaacaaca gacactgttt 987841 acaaagaggc gctggagcat ccgcggatga caacggagga tcgtgattat gtcatcaaat 987901 caatcaatta catgttcccg gaactgaata tcactgcgaa tgacatcgaa tccagctggg 987961 cggggctgcg tccgctgatt catgaagaag gcaaagatcc ttctgaaatt tcacggaaag 988021 acgagatttg gacatctgac tcaggcctga tcaccattgc cggcggaaaa ctgactggat 988081 acagaaaaat ggcggagcac atcgttgatc ttgtccgtga tcgcttaaaa gaagagggcg 988141 aaaaggattt tggaccatgt aaaacgaaaa acatgccaat ctctggcggg cacgtcggcg 988201 gttcgaaaaa tcttatgtcc ttcgttaccg cgaaaacaaa agaaggaatt gcagccggtt 988261 tatcagaaaa agacgcaaaa cagcttgcga tcagatacgg ctctaacgta gatcgcgtct 988321 ttgaccgggt agaagcgctg aaagatgagg ccgcgaaacg caacattccg gttcatattc 988381 ttgctgaggc agaatacagt atagaagaag agatgactgc aacccctgct gacttctttg 988441 tccgcagaac gggacgttta ttttttgata tcaattgggt aagaacatat aaagatgccg 988501 ttattgattt tatgagcgag cgattccaat gggatgagca ggcgaaaaac aaacatacag 988561 aaaacctcaa caagctttta cacgatgcgg tcgtaccgct tgagcaataa atcataacgg 988621 gctgtctgca gcccgttatt tctttttacg tgccgaaagg gggagatctc aggttatcaa 988681 gtgacagagg cacccgcttc atataaaata atggcataag ctgatacata ggaggacgaa 988741 tatgacttgg agaaagagct atgaacgctg gaaacagaca gaacatttag atctggaatt 988801 aaaagagcgc cttattgaat tagagggaga tgaacaggcc cttgaggact gtttctataa 988861 agaccttgaa ttcggtaccg gcggaatgcg cggggaaatc ggcgccggga caaatcggat 988921 gaatatttac actgtgcgca aagcatcggc cgggtttgcg gcatacatct cgaagcaagg 988981 tgaggaagcg aaaaaacggg gcgttgtcat tgcttatgat tcccgccata agtctccgga 989041 gttcgcgatg gaagcggcaa aaacacttgc gacacaaggc atccaaacat acgtgtttga 989101 tgagcttcgc ccgacgccag agctgtcatt cgctgttaga cagctgaacg cttatggtgg 989161 aattgtggta acggcaagcc ataacccgcc tgaatataac ggctacaaag tatacgggga 989221 tgatggcggc cagctgcctc caaaggaagc ggacatcgtc attgagcagg taaacgcgat 989281 tgaaaatgag ctgacgatca cagtggacga agaaaataag ttaaaagaaa aaggcttaat 989341 caaaatcatc ggtgaagata ttgataaagt ttatacagaa aaactgacgt ccatttctgt 989401 acatcctgaa ttatcggaag aagtagatgt aaaggttgtt ttcacaccgc tgcatggaac 989461 tgcaaataaa ccggtcagac gcggtcttga agcactcggc tacaaaaatg taacggttgt 989521 caaagaacag gaactgccgg attcaaactt ctccactgtt acatcgccga acccggaaga 989581 gcatgcggca ttcgaatatg ccattaagct tggggaggag cagaatgcag atattctcat 989641 cgcgacagat cctgatgctg accgcctcgg catcgcggtg aaaaacgatc aaggcaaata 989701 tacagtgctg acaggaaacc aaaccggagc gttgctgctt cattacctgc tttctgaaaa 989761 gaaaaaacaa ggcatcctgc ctgataacgg tgttgttctc aaaacgatcg tcacaagcga 989821 aatcggccgt gctgtagctt cttcattcgg ccttgatacg attgatacgc tgacaggctt 989881 taagtttatc ggtgaaaaga ttaaggaata cgaagcatca ggccagtata ccttccaatt 989941 cggttatgaa gagagctacg gttatttaat cggggatttt gcccgcgata aggacgccat 990001 tcaggctgcg cttttggcag ttgaagtttg cgcgttctat aaaaaacagg gaatgtcatt 990061 gtatgaggcg ctcatcaatc tctttaacga atatggtttt tatcgtgaag ggctgaaatc 990121 cctgacgctg aaaggcaaac aaggagcaga gcaaattgaa gcgattcttg cttccttcag 990181 acaaaatccg ccgcagaaaa tggcgggcaa acaggttgtc acagcagaag attacgctgt 990241 aagcaaacgg acgcttctga ctgaaagcaa agaagaagcc atcgacttgc caaaatcaaa 990301 tgtattgaaa tacttcctgg aagacgggtc ttggttctgt ctccgtcctt ctggaactga 990361 gccgaaggtt aaattttatt tcgccgtaaa agggtcatct ttggaagaca gtgaaaagcg 990421 acttgccgtc ctttctgaag atgtaatgaa gacggtggat gaaattgttg agtcaacagc 990481 aaaataattc aagtatgagc tgggtcattg taaatgatcc ggctttttct ttttctcatc 990541 caaaagtctg aaagaaaatc atcctacaag tgaagcaatg aaatacaaaa aactggtata 990601 atcttaaata caagatcaat gccggagtga gaaacgtgag caaaacgagg atggaaaaat 990661 taaaaacgct gaaaacgatt gcggaaacct taaatcaagg gcacgatatc aaagcaacac 990721 tggatgaggt tttaaaagag ttgctgagtc tgacaaacct tcaatccgga tggatttttc 990781 tgatcgaaga agatgggtct tatacgttag cggccgacgc ttatctgccc ccggctttaa 990841 gccgcaagga aaaagtgctg atgtgcgaag gggagtgtta ctgcctgacg aaattcaata 990901 acggagggct tagaaaagct gcaaatatca tgaactgcaa acgcatcgaa tcagcagaaa 990961 acctgcattg ttttgacaca gaagggatta cgcatcatgc aactgtgcct ttagaagacg 991021 gggacagaag attcggattg ttaaatgtag cggcggccgg aaaaaccatg tttgatgagg 991081 aagagctgca tttactcgag tctgtcgcct ttcagatcgg aacggcaatc cagcgtatga 991141 ggctttctga atatcaacaa aaaaatgctc ttttaatgga gcgtaaccgc ctcgctcagg 991201 agcttcacga ttcagtcaat caaatgctgt tttccgtcag tttaactgcc aaagctgcga 991261 agacactaac aaaagatgaa aatttacagc agatgattga tttcatccaa aacctatcac 991321 aggacgcgct cgcagaaatg aaagcgttaa tttggcagct tcgccccgga ggattggaaa 991381 aagggctggc tgaagccatt aaaagctatg gtgcgctcat tggattgaag atcattttta 991441 cacaaaaagg ctgtcctgtt ctgactgatg agcaggagca tatgctatgg cgtgtcgtac 991501 aggaagcttt aaataactgc aaaaagcatg ccggaacgga tacggcgtat gttagtctga 991561 ctgcttcttt gtgccatgcg gagctggata tcatcgatca tggggcagga tttcgctatg 991621 aagcgcatgc cggtctgcct tcacttggca taaaaggtat gaaagagcga gcggaaaaag 991681 ccggagctaa gttttggatt gagtcagcgc ttggaactgg aacaaagctg tccatcaggc 991741 ttccgctaaa aagccgaaaa ggaggggcgg tatgaaaatt gtcattgctg atgatcatca 991801 tgttgtcaga aagggtctgc gttttttctt tgccacccag gatgatattg aagtcgtcgg 991861 agaagctgca actggattag aagccctccg tgtcatcgaa gagacaaagc cggatcttgt 991921 gctaatggat ttgtctatgc ccgagatgga cggcattcaa gccattaaaa aagcaataca 991981 gcaatttccg gatacgaata tcattgtgct gacgagctac tctgatcagg agcacgtcat 992041 ccccgcgctt caggcaggcg cgaaggcgta tcaattaaag gatacggagc ccgaggaatt 992101 ggtgaaaaca cgacaagtgc atggtggcga atacaagctt tctacagcta ttatgcccca 992161 tgtgctgaca catatgaaaa atcagcacga cccggaaaaa gaaaaatact atcaattaac 992221 tagaagggaa aaagacgttc tgactgaaat agcgaacggg aaaagcaata aagaaatcgc 992281 agcagccttg tttatttcag aaaaaacagt aaaaacccat gtatcgaatc ttttagcaaa 992341 acttgaagtg gccgatcgca cgcaagcagc gcttttcgca gtgaaatata acctgaatgg 992401 agagatctca aaatgaacat gttagtcata aatggcacgc caagaaaaca tggcagaaca 992461 agaattgcag catcctatat tgcagctctg tatcacacgg atttgattga tctaagcgag 992521 tttgtattgc ccgtttttaa cggtgaagcg gaacaatctg aactgttgaa agtacaggag 992581 cttaagcaac gcgttacgaa agcggatgcg attgtattat tatcgcctga atatcacagc 992641 ggcatgagcg gcgctttaaa aaatgccttg gattttctaa gcagcgaaca attcaaatat 992701 aagcccgttg cattattggc agtagcggga ggcggaaaag gcggcatcaa tgcgctgaac 992761 aatatgagaa ctgtgatgcg gggtgtctac gccaatgtca ttccgaagca gctggtgctt 992821 gatccggtgc atattgatgt tgaaaatgct acagtggctg aaaacattaa ggaaagcata 992881 aaagagcttg tcgaagaact cagcatgttc gcaaaagcag gaaatcccgg cgtctaaacg 992941 ccgggatttg tttatgtgag aagggctatt tgatcttcat aagtcagctc tgtggcatga 993001 tcaatatatc ggagaaggga atacagcatc ttttctaaaa cggcgtaatc ctgttcaaaa 993061 tgatacgcat gcagaaaatg ctcaattcgt tttgataaca aatcgtcctc tgtacgcacc 993121 attaaaatta ataaattatc ccattgagaa cgatgggtgt aataaagcgc tttatcgtaa 993181 tcggcataat ccatgaatcg cttctccttt cttgggtgag aagttcatga ttagtttatg 993241 ccgcatcctc tgttattgac ggggcaaaac ttgccgtctg cgtcagtaaa ggggtagcaa 993301 tatgagggag acataaaatc aaaatgcctg aatgaagata tcgcttttgg taaacctatg 993361 agggaatata ttctgggtac aggagactga aaaaatgaaa tccctgccgt ataccatcgc 993421 acttcttttt tgcggattga ttatcgtgtc aatggctgca aaaggtcatt caacggacac 993481 agacgagtcc gttcaaaagt gggaacagct tgcctggagc aaaattcagg atgaatataa 993541 gggcgcttca ttttctgatt atgcttatat ggggcgtaca gaggtgaatg atcagcagac 993601 taaagatgtc tttcgggtga cagtcagaca gaaagatgac actttttctg ttcgggccga 993661 agtctatttt catccggtga caaatcatat gatcagcatc aacgtcttta ggctctaata 993721 aaaaactgta cagccgttaa ggccgcacag tttctgtttt tagaaatatc gttttgcacc 993781 gagatagcgc tgtttccagt aagagttgtt catattggaa atgacaactc cggaatcgtt 993841 ggcatttatg aattccccgt tgcctaggta aattccgacg tgggaagggc cggctttata 993901 tgttgaaaag aaaacgaaat ctccgacagc aggctggcta actgatttca ttgtgttcca 993961 atatcccgct gccgttaatc tagatacgga tgtgactttg ttcagtacat agtaaatgaa 994021 tccgctgcag tcaaacccgg acggtgtcgt gcctccccag cgatacggaa ccccaagctg 994081 cgctttagcg gccgaaatca ttgtgttaat cttcgcactc gttgagctgg tggtgtttga 994141 agaaccggat gaagacgatg atgaagcttt tccggaaatg accagctttt ggccaacctg 994201 caagacatcc gtttttaaat tgtttttctc acgaatctgc tgagctgtta cattaaattt 994261 ttgagcaatc acccataagg aatcaccgct tttcaccgtg tatgtagtcg tcgtgccgga 994321 gcttgcattt gacgaagaag acgacgatga tgaagagcct gaagatgctt tacctgtcag 994381 cttcaatact tgtccaacgt aaagcacatc tgatttcaga ttgttgatat ttcggatttg 994441 ctgtacagtc aggttatagt tgtttgcgat tttccaaagt gaatcaccgc ttttaacggt 994501 atatttagtt gttgctgaag tttggttcga tttggatgaa ttgtctttag aagacgtatc 994561 agagccgctt gattttgttt tcaacacctg attcacgtaa atggtgtctg attttaagtt 994621 gttcaagacc ttcaattcag cgatggacat attgactttg tttgcaattt tccaaagtga 994681 atctccaagc tgcaccttat atgttcccgt agaagatgaa gaacttgaac tcttattaga 994741 actgcttttt gaactggagc ttgaactctt attagagttg ctttttttac tggaactaga 994801 gcttgaagaa acagtaccgg acacctttaa tttctgccca gcacgaatta aatcgctgct 994861 tagtccgttt aattttttca gttcctgcac cgtcatttta aactcatttg cgatcagcca 994921 aagtgaatct ccgcttttca ctgtgtaaac agaacttccg ctcttcttgg ttgttgagct 994981 tgaagtagat gaagaagtgc tggatttgct gcctggaata gtaagcgtct ggccgatcga 995041 cagaacagta gtcgaaagat gattggcgga tgtgagggcc gccacacttg tgttataggt 995101 ttgggccagt ttccataaag aatctccgct tttgacctta atcgttgctg cttcagctgg 995161 tgtcactact aaagttgtgc cgacaatcgc agatgctgtc agccctgctg ctaatttctt 995221 tttcatctta gctctccttt ttcccccaat gattttgcat ttgctgtttc ttttttatat 995281 cggcacattt gtctcatcgt tttgcctttt tataaaaata gccaaattat cttaacaata 995341 agggggaaaa agggcataaa aaaagaagga atcttaatct attccttcat ttttaaaagc 995401 ttcatgatat cttctttgtt tttgacgagg tcgcgcagtg tgtatttgtc taaaactgcg 995461 aggtaggcta aaagcgcttc attcagcaca tgttttaagc cgcaaaccgg ggaaataaca 995521 cagagattct tgttcgcatc aaaacattca acaatattaa aatcgtcctc cgtttttctg 995581 acaacctcac cgatgttgat gtcttcaggg tccatgccta atcgtatgcc gccgccccgt 995641 ccgcgtatcg tttctacgta gccgagctgg ccgagcctgt atatgacttt catgagatga 995701 ttttttgaaa tagaatacgt ttcggcaatc tgttttatat ttgaaagttc tccgggacgc 995761 tctgcagcca gaaaaatcaa cactcttaat gaataatctg tataattggt taacttcata 995821 ataagacctc agaataagac attttctata tcttatcata atcgattgaa aaatgaaaaa 995881 aaaggaatta aaaaacatgc acccagctgg gtgcatgttt tttgcttaca tgtcattcgg 995941 cggattttgg tttttacggt ttttttcgat ttctgtgttt tgcattttgc gttcaaatgt 996001 agacagataa cgtgatgcaa aatccttacc gccaaggccg aaggataaac caaaagcaag 996061 tgcgaagccg ctaagaacga tgatgaacgc ggaattgacg attgtcgcag cgacacccag 996121 ctgatccagg gccataaaga aagcaagtgc gataatcgta tatttagcaa taggcgctaa 996181 agacttgaat tcctgacctt ttatcatgct tgcgagcact tttctcacca attctcctgc 996241 gtaaaggccg agtccgagaa tgaatactgc gacaaggaca ttcggcagat acgcgatgat 996301 gccggtggca atttctacga ggaagtgcag ccgaacaatt tgaagcgcct cagctgtaaa 996361 gagcagaatg acaatgattt gcgcaatcat accgacaact tgagacaagg acagctttgc 996421 aggcgttccg gcttccatgc ccattttccc taagacagaa tcaaagcctg cgcgatggag 996481 cagtccggac accatggatt tcacccattt tcctgcccag atacccgcta atacaagcac 996541 gatggcaatc atgatgttcg gaagcatgtt taaaatcgta ttcagcatag agacagctgg 996601 ttttgaaatg ccggcgacat ccagctgatc aagcgctgaa atgaccaccg gaatcataat 996661 gagcacataa gcgattgttc cgatgactgc tgaaaggctt gtgtctttta agtaaattga 996721 taaacccata cgtgccgcga atctttcggt gccgatgctt gcaaggaaat tcgtaatgat 996781 atcacggaca aggcgggcaa caagccatcc gattaatacg ataagcgccg ctgcaaataa 996841 tttcggcaga aaagcgagca cgctttccat catatttgta aaaggacctg aaatgccgct 996901 gattttcaaa gaagataaga cccctggcag aaaaacaagc agcacgagat aaaagacaat 996961 ttgtgaagcg gtattgacag cctggtgaat atcttttcct tcagacacca aattccactt 997021 gcgcagtttg tcactcgtgt tcagcttcat cccgattttt ttgacaagga agctcaaaac 997081 agaagctgca gcccatccta acagcagaat gagtccggct ttcagcacgc ttgggatcgc 997141 agctgcaatc gccgaaagca tactgacaaa cggcgatgcc actgttgtca ggtgcaaaat 997201 gttaaagaat aaaataaaga cgatgatcag tgcgataaaa taaacgacct tgcttatgac 997261 tttttccgag gaatagcgtg aaggcttttt cccagcaaag agcttgtcgt cgatttttgt 997321 tttgctgagt cctttgtata ccgctttttc aatgatttta gcaatagccc agccgattaa 997381 taagacgagt aaagcaatga ttacgtttgg cagcttactg agataagaag aaaacacgtc 997441 tgctacattc aattggtatc gctccttttt cgtagtatgg tgtgtgttta cccacttatc 997501 caataagcaa acagatgaat gtgccggggg aattttttct tgcccgagtg agactatcat 997561 cttttgtctg gcgggctcat acattataga taagtccaag taggggggat tcggttgaac 997621 gcggaggaga agaagggatt acagcgggca attgaggaaa ttaccgaaat tgcaaaagga 997681 ttcggccttg atttctaccc gatgagatat gaaatctgcc cggctgaaat tatttataca 997741 tttggcgcgt acgggatgcc gacaagattc agccactgga gcttcggcaa gcagtttcac 997801 aagatgaagc tgcactatga tctagggtta agtaagatct atgagctggt cattaactca 997861 gatccatgct acgctttttt gctggacagc aactcactga tccaaaataa attgattgtc 997921 gcacacgttc ttgctcattg cgatttcttc aaaaacaact gccgtttcca aaacacgaag 997981 cgcgatatgg tggaaagcat ggcggcaaca gctgaacgga taaaacacta tgaacaggtt 998041 cacgggataa aagaagtcga atctttttta gatgcaatcc tttcgattca ggagcatatc 998101 gatccgtcgt tggtccgacc aaagctccaa tggagtgtgg atgatgagga agaggagatt 998161 gaagaggcag ccacgcctta cgatgatcta tggtctttag atgaaaagaa accgaaaaaa 998221 caagtgaaaa aatcgaaaaa accgttcccg ccgcggcctg aaaaagatat cctgcttttt 998281 atcgaggagc attcccggga gctggagcca tggcagcgtg atatattaac gatgatgaga 998341 gaggaaatgc tttatttctg gcctcagctg gaaaccaaga ttatgaatga gggctgggct 998401 tcctattggc accagagaat tatacgtgag cttgatttaa cctctgatga agcgatcgag 998461 ttcgccaagc tgaatgcagg tgtcgttcag ccgtccaaaa caggcattaa tccttattat 998521 ttagggctga aaatatttga agacattgaa aagaggtaca acaacccgac ggaggaaatg 998581 aagaaaatgg gcgtgcagcc tgactccggc cgggagaaaa tgtttgaggt cagggagatt 998641 gaatccgata tctctttcat ccgcaattat ttaaccaaag aattagtcat gcgcgaggat 998701 ctttatttgt ttcaaaaaca gggccgagat tataaaatca tcgataaaca gtggaagtcg 998761 gtgcgcgacc agctcgtaag catgcgggta aatggcggtt ttccatattt gacagtaaac 998821 gacggcgatt atatgaaaaa taacgaactc tatattaagc attggtatga gggcatagag 998881 ttggatttga aatatttgga gaaagtgctt ccttatttat tccagctttg gggaagaagc 998941 gtgcacattg agtctgtgct tgaggataag gaagtcatgt tttcgtacga cggaaaaggt 999001 gttcaccgca gatatttata aaaaagagga tgcagcgttc tgcatccttt ttattttcca 999061 gtttttaaaa tcttaaatat gatgtttgcc tggtccgtat tgttaatcaa tccgcggaat 999121 ttttcttttc cggggccgta cgcgtatacc ggtacttctt cgccggtatg atcggtactc 999181 gtccatccgc tgttggagcg ggtattaaaa atcttgatga tggctttgga ggcccctttg 999241 cttttgtcag cctgtgcagc tgcttcaacg cttttgattt cttcagatgt gactttcaga 999301 ttggcatagc gggcgagcac atctttaacc ggcttgcctt cactgatttt tttggccatg 999361 aattcaggtg ttttcttagc ggagagaatc ggttctgcgt gccaattctt ttccccgttt 999421 gcgccaatgg taaagccgcc ggttgtatgg tcagcagttg caatcacaag tgtatgtttg 999481 tcttttttcg caaattcaat cgcggcttta taggcctgtt caaaatcttt aacctcgctc 999541 atggctccta ctgtatcatt gtcatgggcc gcccagtcaa tctggctccc ttcgaccatc 999601 aagaaaaatc cttttttatt ttggttcagg cgatcaattg ctgaaaccgt catgtctttg 999661 agagacggtg ttttactgtc acggtcgagc gctttagcaa gccctccatc tgcgaaaagc 999721 ccgagcacct gctgatcttt attttttttc aatgcttgtt tagttgtcac atagctgtag 999781 ccggcttgtt tgaattcctt tgtcaagttt ctgtccttgc ggttaaaata agattttccg 999841 ccgccgagca gcacgtctat tttatgtttg ccttttatct tgtcatccat atagctgttg 999901 gcgatttggt ccatgttttt ccgtgattca ttgtgggcgc catatgcggc tggagtggcg 999961 tggttaattt cagacgtggc gacaagccct gttgacttgc cttgctgttt ggcctcttca 1000021 agtacagatt tcactttttt tccgttttta tcgacgccaa ttgcattgtt atatgtctta 1000081 acgcctgtcg ctaatgctgt tccggctgct gctgaatctg taatattata gtcagggtca 1000141 tccggatgcg tcatcatcat gcctgtcagg ttccggtcaa attctgttaa cttcgggtta 1000201 ttcggtgtgt caccgttatt tttcatggaa cggtaggctc ttatgtaagg cgtccccatg 1000261 ccgtcgccta tcatcacaat gacatttctg atctcagctt tgtcttgttt tttggcgctg 1000321 gccttttctg tttgctgaag ctcagctccg gcaaagattc cagctgtaag gacagaaaca 1000381 gcggcgattg gcagaagttt tgatttcata ttttgaaaca aactcatttt tttcatgcct 1000441 cctttaatgt attccgttta tcatgttagg gaaactttgt taaatgcggc tgttgatcat 1000501 gtaaacaata agtaaagcct tgtaaggaaa tgaaaaaacg cttttcgtta tcttgcctta 1000561 tttgatgtaa agcattcatt tttcagaaaa atctttacct ctctgtcttt gcatgatatg 1000621 tttgtttaaa taaaaaaact gcggataacc acagctctcc tcgaatatac tttatcactc 1000681 atttttccga tatatgagcc gaccccgaaa gtttttcatt tatttccttt atgttgaaaa 1000741 acatcccata aaacatgaca aaagcactcg ttttttgtca cctttgcaat gaaaatgaaa 1000801 tatttaatac ccttaaaaac ttttttttag aacgaataat taagaaattt gtcacatgaa 1000861 gtcaagacta tttctgatgg gaatctatcc ttataataga aatcaataag attaatttaa 1000921 aaaaagagat acatatatat agagttaaca tttggggagg aaaatatgaa aaagcaaatc 1000981 attacagcta cgacagcagt tgttttagga tcgacgttat ttgcaggagc ggcatctgca 1001041 caaagcatta aggtgaaaaa aggcgacacg ttatgggatc tttcaagaaa atacgacaca 1001101 acgatcagta aaattaaatc agagaaccac cttcgttcag acattattta tgtgggacaa 1001161 actttatcga ttaacggcaa atctacaagt tcaaaaagca gcagttcttc ttcctcttct 1001221 tctacataca aagtaaagag cggggacagc ctttggaaaa tttcaaaaaa atacggcatg 1001281 acaatcaatg aactgaagaa gctgaatggc ttaaaatcag atttgcttcg tgttggacaa 1001341 gtcctgaaac tgaaaggttc aactagttca agcagctcca gctcatcaaa agtgtcatcg 1001401 tcttcaactt ctacttataa agtgaagagc ggagacagcc tttctaaaat tgcgagcaaa 1001461 tacggcacta cggttagcaa attaaaaagc ttaaacggct taaaatcaga tgtaatctat 1001521 gtcaaccaag tattgaaggt gaaaggaaca agcacaagca gctcaaaacc tgcttcatct 1001581 tcatcgtctt caagcagcaa aacgtcatct acatcactta atgtgagcaa gctggtttct 1001641 gatgcaaaag cgttagtcgg aacgccatat aaatggggcg gaacgacaac ttcaggcttt 1001701 gactgcagcg gattcatttg gtacgtactg aataaacaaa caagtgtggg cagaacaagc 1001761 actgcaggat actggagttc tatgaagagc attgccagcc cgtctgttgg tgatttcgtc 1001821 ttcttcacaa catataaatc cggcccttct cacatgggga tttacattgg aaacaacagt 1001881 ttcattcatg caggatctga cggcgtacaa atcagcagcc tgaacaacag ctactggaag 1001941 cctcgttacc tcggtgcgaa aagattctaa tttttagaga aaacccgttc attggaacgg 1002001 gtttttttca ttagacggag cacaggcgtt ttggttgctc ctaaaaatga aaatgtgata 1002061 aaaaatccaa gaactttttt tctttcttat tttcataaag ggcaatcgcg taagcgccgg 1002121 catagggcag ctgtacagac tgataaggaa ttctgatcat ctgtttctct gctaactcac 1002181 gctttactgt agataaaggc agaaatgaaa ctccgagtcc ttccttgata aaccgtttcg 1002241 ttatatgtgt ttgagtgacc ttcattgttc tcacaaatgg aaatgtcatt ctgacttgac 1002301 ggagcaagtc gtcccagtaa tcaggatgat tgtgggtcaa aagcaggtat tgttcgagca 1002361 cctctttggc atcaatttcg ttgtcttcta tgaaacgctt atcgggcggg gcaacaagga 1002421 cgacagggtc tttgtataag cagtggcagc ttaaagaaga agactgtacc tttaaacagc 1002481 ttagtccgat atctgcttcc ccggctttaa tcagtgacgc gatttccgct gattcgaaaa 1002541 tcgtaaccgc catttctgtt tccgtattca ttgctgtgta ccgcttcatg acagaaggaa 1002601 gcactgtatc tgcaataagc ggagaaaccg cgagctgtaa ggtttgagag tagccttgtc 1002661 tcactctgtg aagctctgcc atgctgtttt cataatcatc aagaagcctg agcgcatacg 1002721 gcaaatacgc cctgccttca tcagtcagct ggatttgcct gcctttacgc tcgaacagct 1002781 tgcagctgat ttctttttct aattgcttga tatgtacggt cacagtaggc tgagataaga 1002841 aaagcgtttc cgccgttttt cggaagttct catattttgc agcggtcaca aaggtgtgaa 1002901 gccatttgaa atccatttct attctccctc tgattaatat ttttaattaa ttccctttaa 1002961 aatattgatt attttttaaa tattatattt actataataa cagaaaagga tagggggaat 1003021 acaaatggta cattacggat taaagggaat tacatgtgta gaaacatcca tcagccatat 1003081 tgatggtgaa aaagggcgtc tgatttacag aggacatcat gcaaaagaca tcgcactgaa 1003141 tcacagcttt gaagaagcgg cttatttgat tttatttgga aaactgcctt caactgaaga 1003201 attgcaggta tttaaagata agctggctgc ggaacggaat cttccggaac atattgagcg 1003261 cttgattcaa tcactgccaa acaacatgga cgatatgtcg gtgctgagaa cggttgtttc 1003321 agcattgggg gaaaatacgt acacattcca tccgaaaaca gaggaagcaa tccggctgat 1003381 tgcaatcacg ccttctatca ttgcatacag aaaaagatgg acgcgcggtg aacaagcaat 1003441 tgcaccttct tcccagtacg gacatgtcga aaactactat tatatgctca caggtgaaca 1003501 gccttcagag gcaaaaaaga aagcgcttga aacctatatg attctggcca cggagcacgg 1003561 catgaacgca tcgacttttt cggcacgagt cacgttatct acagagagtg atttagtgtc 1003621 agccgtcacg gctgctctcg gtacgatgaa aggtccgctg cacggaggtg ctccttctgc 1003681 ggtgacaaaa atgcttgaag acattggaga aaaggaacat gctgaagcat atctgaaaga 1003741 aaaactcgaa aaaggagagc gcttgatggg attcggccac agggtgtaca aaacaaaaga 1003801 cccgcgggca gaagctttga gacagaaagc agaagaggtg gccggcaatg accgtgatct 1003861 tgatcttgcg ctgcatgtag aagcagaagc gattcgtttg ctagaaatct acaaaccggg 1003921 acgaaagctg tacacaaatg ttgaatttta cgcagctgca gtgatgaggg ccatcgattt 1003981 tgacgatgaa ttgtttactc cgaccttttc agcaagccga atggtagggt ggtgcgccca 1004041 tgtactggaa caggcagaaa acaacatgat tttccgcccg tcagcgcaat ataccggtgc 1004101 cattcccgag gaagttcttt cataacatat tttggcgttt attcatttct gtcgtgtggt 1004161 aacgttcagt atcaaccaca tgtctaggag tgatgaatgt gaacccaatg gacagacaaa 1004221 cagaaggaca agaaccgcag catcaggaca gacagccggg cattgagtca aaaatgaatc 1004281 cgctgccgct gtcagaggac gaggattatc gaggaagcgg aaaactgaaa ggaaaagttg 1004341 cgatcattac tggaggcgac agcggaatag ggagagcagc agctattgcc tttgctaaag 1004401 agggggctga tatctccatt ctatacttag acgagcattc ggacgcagag gaaacacgca 1004461 aacggatcga aaaggagaat gtccgctgcc tgcttatccc gggagatgtt ggggacgaga 1004521 accattgtga acaagctgtg cagcaaacag tggaccattt tggtaaactc gatatcttag 1004581 tgaacaacgc cgctgaacag catccccagg acagcattct caatatttca acagaacagc 1004641 tggaaaaaac ctttcgcaca aatatttttt ccatgtttca tatgacgaag aaagctttgc 1004701 ctcacctgca agaggggtgt gccattatta atacgacatc gattaccgct tatgaagggg 1004761 atacggcgtt aattgattat tccagcacaa agggtgcgat tgtttccttt acgcgttcca 1004821 tggcgaagtc gcttgcagat aaaggcatca gagtgaatgc ggtggcgccc ggtccgattt 1004881 ggacaccgct tattccggcg acattccctg aggaaaaagt gaaacagcac ggcttggata 1004941 ccccaatggg aagaccggga cagccggttg agcatgcagg cgcctatgtt ctgctggcgt 1005001 ctgacgaatc ttcctatatg acagggcaga ccattcatgt gaatggcggc cgttttattt 1005061 caacgtaatc aacgaaaaac cagctcaaga gctggttttt tgtgtggtga aaaatttcaa 1005121 aataaaaaat ttgtcgattt ttctaacaat tttgttttca tttttgcaat tttatatata 1005181 atattgagta ggagaaagga atgattcgcg accagtacaa atatagtaga aaaaaaagaa 1005241 taatgaccat tgttactcat gaattcagaa aattcaaata aaatatataa aaatagatga 1005301 tcgggagttg aaggggaatg aaagggagcg tttttaggaa gaaaagcatt caggatttaa 1005361 tcgctgcgac gagcggggaa aagtctttaa aaagagaatt aggggcattt gatttaacgt 1005421 tgcttggaat cggcgccatt attggcacag ggatttttgt tctgacggga acaggcgcag 1005481 tcacggccgg tcccgggctg acgatttcat ttgttgtggc ggcgttggct tgtttattcg 1005541 ccgccctgtc ttacgcggaa tttgcgtcaa gtgtgcctgt ttcaggttcg gtgtatacat 1005601 tcacttatgc gacattggga gagcttatgg cctttattat cgggtgggat ttaattttag 1005661 aatacatgct ggcggtaagt gcagtgtcgg tcggctggtc tggttatttc caatcgtttt 1005721 tatcagggct tggcattcat cttccggttg ctttaacagc ggcaccgggc gcagtgaaag 1005781 gcacctttac cctgtttaat cttcctgcat tcgtcattgt aatggcgatc acatatttgc 1005841 tttatttagg catcaaagaa tcaaaaagag tcaacaatat catggttatc ttgaagatac 1005901 tggttgttct gctgtttatc gcggtggcag ccgtttacgt gaagccgcac aactggcagc 1005961 cgtttatgcc aatgggcttt ggcggcgtgt tcagtgcagc ggcgctcgta ttctttgctt 1006021 ttatcggatt tgacgctgta tcctctgctg cggaagaaac gaaaaatccc gcgaaggatc 1006081 tgcctaaagg cattattttc tctttactgg tctgcacgat tttatatgtc accgtatcag 1006141 ccatcatgac tggggttatc ccgtttgctc aatttgcggg tgtggatcat ccggtttctc 1006201 ttgttcttca aagcgcaggg caaaattggg tggcaggcat cattgatatt ggcgccgtgt 1006261 tgggaatgac aacagttatg ctcgtgatgc tttacgggca gacccgcgtc atgtttgcca 1006321 tgtcgcgtga cggacttgtg ccgggttcac tttctaaagt gcatccaaag cacaaaacac 1006381 cttatgtagc cacttggttt ttcggaacga tgtcggcgct tctcggctca cttgttccgc 1006441 tggatgaact tgcaaagctg gtgaacatcg ggacgttgtc ggcatttgtc ctgatttctg 1006501 tggcagttat cgttttgaga aagaaacagc ctgatcttcc gagagctttt aaatgcccgg 1006561 gagttcccgt gatcccaggc ctggcgattc tgttctgcct gttcttgatt ttaaatctgg 1006621 gatgggtgac gattgtccgc ttcctagtgt ggctgttaat cggcttggta atctatttcc 1006681 tgtattcaag aaagcattca aaattaaatc aataaccttt tgataaagag agcggccata 1006741 caggccgcct cttttctgtt cttggcaaat gaatctatag aaatgaagac aaaaataaga 1006801 gataatatag gctggaaagg aagtgacgtt tattgtctga gcaaaaacca gtccaatggg 1006861 cttcgaaaat tggtttcgtc atggcagcgg ccggctcggc tatcggcttg ggcgcgattt 1006921 ggaagttccc ttacgtagcg gggaccaatg ggggaggagc cttttttctt atcttcgtgt 1006981 tatttaccat cctcttaggc tatccgcttt tggtggggga atttattttt ggaagacgga 1007041 accagacgaa tgccattgat gcatataaaa aagaagcgcc gcgatcagct tggtttctta 1007101 cggggtggat cggcgtagcg gcgtgtttct tagtgctgtc gttttacagt gtaatcgggg 1007161 gatggatttt gctgtatatc gtgaaaacag cgtcaggatc actgtccggg ctttctcaag 1007221 cacagtatgg cgctcttttt gcttctatta tccaaaatcc ggtgcagacg ctcgcggctc 1007281 agcttgtctt tatggcactg actgtactcg ttgtcgcaag aggggttcaa aaagggattg 1007341 aacgggtaag cgcggtgatg atgccgattt tgtttttatt gtttattctg ctcgttcttc 1007401 ggtctcttac gcttaatggt gcaatggaag gcgtaaagtt tctgcttgtg cctcatttcg 1007461 gcgatctgac tccggaatcc atattattcg cgctgggaca ggccttcttt acgttaacac 1007521 tgggggtttc ggtgatggtg acctacagct cctatttgcc gaaaacacaa aatatccctc 1007581 gttcggcagc ctccattgtc ttgatgaata tcattgtgac actcttggca ggtttggcta 1007641 tttttccggc ggttttctca ttcggttttc agccaaatga aggaccgaca ttgctgttta 1007701 cagtgcttcc ggccgttttt gaacagcttc cgttcggcac attgtttttt atcggctttc 1007761 tcgttgcatt tttatttgca gccttaacct cagcattttc gatggttgaa attatcgttg 1007821 ccacaatcgg aaaaggggac gaaaagaaga gaaaaaaact gtcatggacg agcgggcttt 1007881 tgatcttttt ggtcggaatc ccatgctgct tgtcttatgg cgttttgagt gatgtgcacc 1007941 tatttggcaa aacgtttttt gatattgccg attttaccgt cagcaatgtt ttgatgcctt 1008001 caggcgctct gttaatttct ctatttatcc cgctgaaaat ttcgaaaagc gaactcttgg 1008061 ctgaaatgcg aaatggatca aatgcaggta aagcattctt ttacacatgg ttttatttgc 1008121 ttcgttttat cgtgccgctt gccattatta tcgtgttctt aaatttaatc ggaattttat 1008181 cattttaaaa aacaggctcc gtttccgggg cctgtttttt atttaataag atgatatcaa 1008241 cggtgcccat gccgttttca gtttttggat gccgagcctg atgtcctctt ctgacaaacc 1008301 gccataaccg attaagacag aagtaaaagg cgtctgttct atatatgagg gagacacggg 1008361 atagagggtt acaccgtggt cagcggctgc ttgtattgct tcttcctcac ttgctggaaa 1008421 caaaaggcgc agcagaatgt gaagccccga gttcttaccg agaatctcaa cggtgtttcc 1008481 cagttcagag cgaatggctt ctaacaggac agcgtgtttt tttcggtata agcttctcat 1008541 tctatttatg tgtttttgcc actctccggt ttcgatgaag tctgccagtg ccaattgcga 1008601 gtgggcagaa acggtctgct tcattaactg aacattgttt tggatcggtt ccatgagttc 1008661 agggggcaca atcatgaagc tgagccgcaa ggaaggcaga agtgactttg aaaaagtgcc 1008721 cagatatatg actctgccat tcggatcaag accctgtaaa gacggaatgg gatggccgct 1008781 gtagcgaaat tctccatcgt aatcatcttc tataatgaat gaatttgttt ctgccgccca 1008841 tgccagcagc tcctgtctgc gggtaatcgt cataatggtc ccaatcggaa actgatgcga 1008901 aggagtcgta tacatgagat aaggattctg acggtagagc tcatccggca ggacgccttc 1008961 tgcatcagaa caaatcggag tgacatccat gtgatttgct tcaaacatcc ttcttgaacg 1009021 gtgaaagccc ggttcttcaa agccgatttt tgtacctggc tttagcgaaa ggcaaagatt 1009081 ttgcagaagc acggtggttc ctgcgccgat gataatctgg ccgggttcac aatttactcc 1009141 ccgagacagc ctgacgaatc gggcaatcat gtgcctgagt tcgtattctc cttgagggtc 1009201 gccagaggtg tgaaacgatc cggaatagcg atcaagactt tttactatgc tttttctcca 1009261 tgcgttaaag ggaaagaggg tcggatcaac gctgccctga tggaagtcaa tagcaggtgc 1009321 gtttttttga tgtaatcccg gctgtacaga ctgctgaaaa tggtcaggag ctgtcgggaa 1009381 tcctggttct acttccgccg cgaaccagcc gattttcggc ttgcttttga catagccctc 1009441 agcagttaat tgctcataag ctcgttctat agttgccgtg ctgacatcga gcaagctgga 1009501 gagcctgcgt tttgacggaa gtcttgttcc ctttgtgatt cgcgcatgtg aaatttcttg 1009561 tttaaaaaag gtataaagct gttcatacag cggtgttttg ctctttttat caagaaacgg 1009621 cgtaatatcc atctcatgtc tcctttgtag ctggcatggt cattttttct gatattggct 1009681 atttggcaaa tgccatttat tagctatgat cattgtaacg aaaggaaagg ggattgagaa 1009741 gatgatccat atgaaacaat taacctcgaa agaagaatgg gctgagtcgt atccgattat 1009801 gagtgaattg agaacagaac tggatataga gacgtattta caaaggcttg aagcctgtgt 1009861 gcagaaagaa tcgtatatgc tgtttgcctt atatgaaaat acagcaatca gagcgctgtg 1009921 cggggctctg ccgagagttt ccattcataa aggagagcac ttgtggattg cggatcttgt 1009981 tacaacggca ccttgccgat caaagggata cggcaaaatg cttttggatt atgcctcaga 1010041 ctgggcgaga aaagccggac tcggttttgt cagtctttca tctggccttc agcgtaaaga 1010101 cgcacatcga ttttatacag ataaaatggg ttttactata gaaagttatt tgttccgaaa 1010161 accggtataa cgaaaaaaga cgcctgaaaa ggcgtctttt ttaaaagcca aactgtaaat 1010221 tcgtatctac agatacaatg gtatacacac aaataatcac aaagagatta aggatgacgc 1010281 cgagcaggcc tggacctgtg cgccctctct tgatgaagag ttcaacaacg ccgaacggaa 1010341 cggcagccat ggcgaacgga agcatttgat aggaataaaa cgtgacgttg ctgataatgg 1010401 ccaaattcag caacagcagg gacagaaccg ctgtcccgac agagatccag ccgaatacat 1010461 tgtgttcttt aaaaattctt accagttcca taattccacc tcgccgacat tcgctgattt 1010521 tacagattta tttttcagca tgcgctggat ttccttggtt ggccctgtaa cgaccgaacc 1010581 gtatacattg acaccgtttt tctctacata atctaatcgg ttatctacat tcaggtcttt 1010641 ccgttttgaa atgacctgag cccatttttc gtgtttggac atgaatttca gggcgttgat 1010701 aaactgatcg ccattcgact tgccttttgt attaagggcg gccaagaact ttgaatcctt 1010761 tccaggatag ccaagaggtt ctgtggaagc tgtcttattt gtgtttttct ctgtttcgat 1010821 tgcgttccac aaaaagctca catcatagcc tttgaatttg ttatacacgt cttttgtcgg 1010881 atatgcacgg tcatatgaaa ggtagacctc tgataccgtt ccttcaggca atgtgcttaa 1010941 cgttttttct gcttttgcgg tcgtttgttc agacttgttt gaaggatgtg taaagtaatg 1011001 gccggtttta ttcacttcta agtcatagta gtttactgcc ggcgctttta ctttgttata 1011061 aaacatttca acccgttcat tccctacggc agccgtcttc gtgccaatct gcttttgcag 1011121 cgggaattcc gtattcattc caaatagctt cacttggctt ttcagtccgg aagtatcaac 1011181 aagaacattc ggcatggtca gggctacagt gactgcggca gtttccataa actcattgcc 1011241 ggtgctgtgt tttccaccca ttccgtaata gaggtagctt cccagcgtac aaagcggcaa 1011301 aatcatcaat gtcgaaatga cggcaagcac agaaattcgc aaataagact tgcgtttgcc 1011361 gtaggctaaa atcgcttttt gtttttcagg actgatgctg agatcccaat cgttatcgtc 1011421 ctctagttcg ctgtcaatca gttcctgata tacttcaagc ttctcgagtt cttcctcaaa 1011481 tgcagtcatt tcctggtcgc tcatttcccc atttttatat tgatcaaaac gctttttaaa 1011541 ttcttcattc atcattaaca cctctattat aaagtgcttt cagccgctgt ctggcacgaa 1011601 ataaaacact tttaaaattc gcctctgaaa tattcataat atgggatgct tctttgtagt 1011661 ttaactcttt taaataatat agcgttaagg cctcccgata attatcgggg agctcggaca 1011721 tataaccagt cagcacttcc tttatctcta cctgatgggc aggactttga acagcatttt 1011781 gaaagaggct tccgattaag tcatcagaaa tggttacttc tttcttatgc tttctgacgt 1011841 aatcaatgaa ggcgtttcgc gccacttgaa aaagccaggg ctttactttg ctgtgatcat 1011901 aggagtgaat gtgtatgtat gcccgcataa aggtttcctg cagtaagtct tcagcaagat 1011961 gcttgtcttt tgtcatggag agcaggaacc tgtaaacatc attcatgtac atttggtaaa 1012021 tttcatcgat cgtcactgcc ttttctcccc tctatgttat acacgcataa gaaaggttta 1012081 aagttgcaca ttacatgcaa acggcttttt tatacctaat caaacaccat tactatatag 1012141 tacccaaaaa tggccgcaaa agatagtgcg gagaaaggtt taacattttt tccagagggg 1012201 aaaagatagt gaaaaagtga aggagtggca caatggaata taccagtata gcagatacag 1012261 gaatagaagc ctccagaatc ggcctcggca catgggccat tggcggaacg atgtggggag 1012321 gcactgacga aaaaacatcg attgaaacaa tccgcgccgc tcttgatcag gggattacac 1012381 tgattgacac cgcaccggct tacggcttcg ggcagtccga ggaaattgtc ggaaaggcaa 1012441 tcaaagagta cggcaaaaga gaccaggtga ttctcgcaac gaaaacggct ctggactgga 1012501 agaacaacca gctgttccgc catgcgaaca gagcgagaat tgtagaggaa gttgagaatt 1012561 ctttgaagcg gcttcaaaca gactatattg atctttatca ggtgcattgg cccgatccgc 1012621 ttgtgccaat tgaagaaacg gctgaagtca tgaaggaatt atatgatgcg ggaaaaatcc 1012681 gggcgattgg cgtcagcaat ttttcaattg agcaaatgga tacatttcgc gccgtcgcac 1012741 ctctccatac gattcagcct ccatataatc tgtttgaaag agagatggaa gagagtgtcc 1012801 ttccttatgc gaaagataac aagataacaa cattattata cggcagttta tgcagagggc 1012861 tgttaacagg caaaatgact gaagaatata catttgaggg cgatgatctg cgtaatcacg 1012921 atccaaaatt ccagaagccc cgctttaaag agtatctttc tgctgtgaat caattggata 1012981 agctggcgaa gacacgttat ggaaaatcag tgattcactt ggctgtcaga tggatcttag 1013041 atcagccggg agcggatatc gctctttggg gagcaagaaa gcctgggcag cttgaggccc 1013101 tatctgagat tacaggctgg acgctgaaca gtgaagatca gaaagatatc aatactatat 1013161 tggaaaatac gatatcagac cctgtcggac cggagtttat ggccccgccg accagagagg 1013221 aaatataaca aaagctgagg gcgaatcctc agctttttgg cgtttaaacg agagaaatct 1013281 taaaaattag taccaggtaa taaaaaatat tgttataata gatgacagaa agaatcattg 1013341 attacgacaa aggaagtgcg atatgtataa gttttgtgca aatgctttaa aagttattct 1013401 ttctcttcgc ggaggagtga aggtgtataa caaagaaaac cttccggccg attcaggttt 1013461 tgtcatcgcg tgtacacatt ccggctgggt tgatgtgatt acactcggag tcgggattct 1013521 tccttatcaa atacactaca tggcgaaaaa agagcttttt caaaataaat ggatcggttc 1013581 gtttctgaag aaaattcatg cctttccggt agatcgggaa aatcccgggc caagcagtat 1013641 taaaacgccg attaagctgc tgaaagaagg agagatcgtc ggtatcttcc caagcggaac 1013701 aagaacctct gaggatgtgc ctttgaaaag aggtgcggtg acgattgcgc aaatggggaa 1013761 agcgccgctt gtccccgctg catatcaggg cccttcaagc ggaaaagaat tattcaaaaa 1013821 aggaaaaatg aagctgatta tcggtgagcc tcttcaccag gctgattttg cccacctgcc 1013881 ttcaaaggaa agacttgcag caatgacaga ggctttgaat cagcggatta aagaactaga 1013941 gaataaactt gatcagctat aaggcgttct gagagattgt cctgaaactg tgaaaataag 1014001 aaaagcaccc tatacaaggt gcttttctta ttatgcttcc tgctggttag ctgtctccag 1014061 aagttcttct tcttgaagct ttttcacttc aatatatgcg acgtggtggc cgtcaatttc 1014121 attaatgatg aattcgcagc cctcttcgat gatggaatca tctttttcaa catcgtattt 1014181 ttgagtaagg aaccagccgc cgattgtatc gacttcttcg ttctctaaat ggatgcctag 1014241 caggtcgttt acttggtcaa ttaacacttt tccgtcaaga atataatggc cttcgccgat 1014301 tttgcggatt tcgctaattt catcaatatc aaattcgtcg cggatttcac cgacaatttc 1014361 ctcaatgatg tcctcaaccg tcacaagccc ggcagtaccg ccgtattcat cagacaaaat 1014421 ggccatgtgg accctctctt tttgcatttt gacaagcagg tcttggatcg gcgcagattc 1014481 aatgacatga atgatagggt tgacgaattg agaaatggtg gaatcaacag atacctcacc 1014541 gctgatgcag gcggtcagca cttctttaat gttaataacc ccgataatgt tatctttatc 1014601 gccctcttcc acagggtagc gggtatattt ttcaatctga atgatgtcca tcatttcaga 1014661 aatcttgata tcatgcggaa ggctgacaat ttcggtccgc ggaatcataa tttctttcgc 1014721 gagcctgtcg tcaaattcaa agattttatt cacatattta aactctgatt ggttgatttc 1014781 accgctttta tagctttcag acaaaatgat tcgcagctct tcttctgagt gagccagttc 1014841 gttttctgaa acggtctcca ggccaaatgc tttggtcaat aaccgtgcgg aattgttcaa 1014901 aagccaaatg aatgggaacg cgatgcggta aaaccaaatc agcggtttcg caaacagcat 1014961 agacactgct tccgcctttt ggatagcgac tgttttaggt gcaagttctc cgacaacaac 1015021 gtgtaagaac gtgataatgg catacgcaaa aataaacgat atgacatgtg aaagggaacc 1015081 tggaacgttc atttggacga aaagcgggtg aagcagcctt tcgatcgttg attcacctaa 1015141 aacccctaat ccgatggaag tcaatgtaat tccgagctga cacgcagata aatattcatc 1015201 aagatgcgtg gtcacttttt ttacggctat tgctgcttta tttccttccg cgatcagctg 1015261 atcgatccgt gagcctctga ttctgataat ggcaaactca gatgccacga aaaatgccgt 1015321 cagggcgatt aaaacagcaa ctaaaatcaa attcactatg tccaattaga accttcactc 1015381 tagcaatgag aatgaaggta acacctcctg ttagataaaa tggttttaac ttaacagcag 1015441 cataaatgat tggaacacgg cgagcttttc aggcgggagt ttgcttttca gcttgtcacg 1015501 atcctcgggc ttcagccgtt caaaccgatg caagattccg gagatgtttt gattcatatg 1015561 atcaatttct aatgccagat ttccaatttc atcatcaagt ttagctgaag agggaaactg 1015621 gttctccagt cgatctttaa tatcggacag ggccaatcgc tgcttcttgc aatctacaat 1015681 aaatataagt cgtttgagtg cattttcgtc gtagtaacgg taatttgaac aggatctggc 1015741 cggcgtaagc agaccgagat tcgtataata atcaactgtc cgtttcgtta ctccggcgag 1015801 tgccgctagt tcactgatgc gataagtctc agccccatct atatccctcc caaccatcac 1015861 gttatagtta tgagaatagt ttaatatatg aacggtgtct tgcacaagtt tattgttttt 1015921 tttagaccgg aattggaagt tgtggaattc atcatctgat tgaagtaaca taggaagata 1015981 gaattttcaa atttttatat gcggaaggga cagatgaaat tggctgggtt atcccgggaa 1016041 gttgaagaaa acttaaataa aggatcatgg attcgcaagc tgtttgatga aggtgcaagg 1016101 ctgaagaagg agttcgggga agaccaggta tttgattttt cactcggcaa cccgattgtt 1016161 gaaccgcctg aagcttttaa gagagcgtta atagaggaag ctgaaaaagg cagccacgga 1016221 tacatacaaa accaagggct tcttgcagcg agagaaaaag tcgcgcaatt tctgggctcg 1016281 cgttttgaag ctgatttctc agcggagcgc atcgtcatga cggtgggcgc gggaggcgct 1016341 ttgaatgttg cgttaaaaag catcgtaaac cctggggaag aggtcattat tcttgcacct 1016401 tattttgccg aatataagtt gtatattgag aactacgggg gaaaagccgt cagctgcccg 1016461 ttgacaagcc ggtttgagat cgacattgaa gcggtaaggc aatcgatcac tccacagacg 1016521 aaagggctga ttctcaatac accgcataac cccacaggca ctgttctcag ccagaaaaat 1016581 atagacgatt taggcgcttt attaaaagaa atagaagaga agagcggcca gacgatttat 1016641 gtgctgtttg atgaaccgta cagtcaatta atctatgatg aagagctggc aaatccgttt 1016701 caatcgtacc atcgtgtgat attggccagc tcattcagta aagatctcgg catagccgga 1016761 gagcggctcg ggtatatcgg attggacagc cgaatgccgg atgcggacct tttgatcaac 1016821 gcttttgtgt attgtaatcg aacgcttgga tttgtgaatg cccctgtcat gatgcagcgg 1016881 gctgtggcac gaatggatga tttaagagta gacgcgagcg cttataaaga gcgccgggat 1016941 ttaatggtag acattttaaa agaagccggt tttgaatttg aaatgccaaa gggaggtttc 1017001 tttgtttttc cgaaatcgcc gattgaagat gaagttgcat tttgcgtgca tgccgcccaa 1017061 aaatacaaat tattaattgt gccgagcagc ggttttggaa tgagcgggca tttccgatta 1017121 tccttcagtg tgccgatcga gcagattaaa aactcacggg acattttcat ttctttatat 1017181 aaagattttg cttaagaagg caaagaaaag aaaacagttt tcaaggctgt tttcttttta 1017241 tatccgcaaa atccttcctc ttccaatcca gacaggcgca gaattgacaa gcaggcatgc 1017301 agttaaggct ttcttcatga taaaagtcta aaaattaaaa atcatttttg gaatgagttg 1017361 tgttacaata aaatatacaa tttataatca aactttgact tttggaggtg gtatgatggg 1017421 gccctctgct taggcaacaa tacaccgcgt acctcaatgt taaggaaaaa tgattatatc 1017481 aggaggtgac tccttatcct ttgttgagag gatagggtta aatggacgat attgacagtc 1017541 tgattttaat tggcgtgctc attgctttaa ccgcgttttt cgttgcaagc gagtttgcga 1017601 ttgttagagt gaggagatcc agaatagatc agcttatcac agaaggaaac aaacgggcga 1017661 tactcgcaag gcgtgtcatt acagatttgg atgaatattt atccgcatcc cagctaggca 1017721 ttacattgac atcaatcggg cttggcgtac tgggtgagcc ggcctttgaa cggctgctgc 1017781 atccactgtt tgaaccgctc ggcttgccgg actcggtttc acatgcagtc tcttttgcag 1017841 tcgcgtacgg cttgatcacg ttcctgcacg ttgttgtagg tgaactggcc ccgaaaacgg 1017901 tcgcgattca aaaggcagaa cagctgactt tactgatagc gggccctttg cgtttattct 1017961 atttgctcct gtttccgttt atttggatcc tcaatggatc ggcgcggctt ttatgcggga 1018021 tgttcggttt gaagcctgcg tcagaacatg atggttccca ttctgaggaa gaactcagga 1018081 tgctgttatc tgagagttta aaaaacggag agattaatcc gtctgaatat aaatatgtga 1018141 ataagatttt tgaatttgat aatcggatcg ccaaagaaat tatgataccg cggaaggaaa 1018201 tggctgctgt gtcaactgag atgacgatgg ccgagatgct tgaagtcatg ctgaaggaaa 1018261 aatacacgcg ctggccagtc acagatggag acaaagacag tgtgctcggt ttggtcaata 1018321 cgaagcattt gttttctgat ttgctgttta tgacagaaga agaacgaatg aagatgacga 1018381 tccatccgta tgtgaggccg gtcatcgaag tgattgaaac gatcccggtt catgacttgc 1018441 tgattaaaat gcagcgcgag cgcattcata tggctatatt gtcggatgaa tacggaggaa 1018501 cctcgggact tgtgacgaca gaggatattc ttgaggaaat tgtcggagag atccgagatg 1018561 aatttgatga agatgaacag ccgctgatcc aaaagcttgg cgacggccat tatgtgatgg 1018621 atggaaaggt tcggatcgat caggtgaaca gccttcttgg cgcatcgatt caagaagacg 1018681 tcgatacgat cggcgggctg atattaaaag aaaacatcga tattgaggct ggtgaatcca 1018741 ttcgcatcgg ttcatatacg ataaaggtgc tgaagatgga cggccgatta atcaagcaaa 1018801 tcgatataaa agaagaagcc ggcaacacaa ccgggattac ggcgcaccac aagctgccgc 1018861 tgcccgagcc tgtgatgctg aacagtgcaa ccttgagcga gaaataagct caaggttttt 1018921 ttatattgtg attgtccagc cgcaccaaaa tgcaaaaagc gacccgcaaa gtgtcaggac 1018981 gatgtacaag atgctttctt ttacacgttt ggccataagg agttgaatag tttcaacgct 1019041 gaatgtggaa aaggtcgtaa aggcgccaaa aaaccccgtg ccaatgataa gcgagaccga 1019101 agcatttgca acgtgaagtc ctgtaaatat tccgagcccg agagctccga gaatattgac 1019161 tgtcagtatg ccaatgggca ggctgagacc tttggttttg gcggttatga cattgccaag 1019221 ccagaagcga agcattgcgc caagtccgcc ccctatgaaa atacccgcta gtgtcatttt 1019281 tcctgcagcc cctttctttg ctgaatgcct gctatgcgcc gtcccacaaa aacaccaatc 1019341 agtgcaaata tgatccctga tatcaatgag gctgccacat ataaaagagc caatgagggt 1019401 tgtccttgca aaagcatcac tgtttcctta gaaaacgtgg acattgttgt gaagcctccg 1019461 caaaagccgg tgcctaaaaa agccgacagc agaggccgtt ttgccccgat cataaaaaat 1019521 ccggtcaaaa tgcctaatag aaggctgcct gccgcatttt ccagccaggt tgccgccggg 1019581 aactgaccgg tgtgtatcca taagtttaat ccgtatcgga ggcaggcgcc aagcgcgcct 1019641 ccgataaaaa ccgcgctata tattttcatg tttgccatcc tttatgatga aatccgggta 1019701 atctgtaacg atgccgtcca cgcccatggc ttgtaatttt gccgctgtct tttgattgtt 1019761 gacagtccat gcaaatatgt ttaagccatt tttattgatg gagccgatca tcagacggtt 1019821 aagccgtgtg tgttttatat tgacatagtt tgcaaaagag cggaaggcct tcatctgatt 1019881 tctggacagc atgccaaagt tgggccttgt aatgaccgct gtcggaatcg aaggataaag 1019941 ctcgcggaac ctttggacgg agcggaactg aaaggattga acaatattat tgatagaaaa 1020001 agaaaattgc cctaatagct gtcccacctc ttcttcaatt ccgacttgag acggatggcc 1020061 ttttagttca attaaaaggc cgattttttt gtggtagcgc ttgagcaccg cttccagggt 1020121 tggaatacgc tctccttgaa aagcgggacc gtaccagctt cctgcatcga gtttttgcaa 1020181 ttcctccaag gtaaaatcct taacaaagcc cgatccgttt gttgttcggt caaccctgtc 1020241 atcgtgtatc acaacaatct gcctgtcttt tgtaagctgg acatccagtt cgatcatatc 1020301 tgcattcatt ttcaccgcaa ggtcaaatgc ggcaatcgta ttttccggag cgtagccgga 1020361 tgctccgcga tgggcaatga tgtacaagct aagtcagctc ctcgtatggg catttctgtt 1020421 attgtatcaa atccatatat gcaccgcgat acaaactggt gaattttttc tgccatatcg 1020481 gaatggtccg ggctgaggaa tgcgtataac taaaaaaaga cactcagcgt atcagaacac 1020541 atttcgtcag aaaattaggt ctttcgacat gttcacaaca aaatatgatc ctttataata 1020601 gcaaaaaagg aggcgagatc atgggaaaag ggagaatcag agtggaggaa agaattaaag 1020661 ccgaaacgga tgctgaaatg caaaaagcaa ctctccttga tcagacacaa acgaaaaaag 1020721 gtaagtgact gtccctattg aatctggctg atagatgaat tgagaaatga ccccggcgtt 1020781 tcgccggggt tttgtgctgc ataagacatt taaatgaaca tccttacgaa tattttagta 1020841 taataaacaa ttgattggga tagaggggag acagtcatgc cggattatct gcagcagtat 1020901 tttacgcttg ataacatcat acaaatcggc atcagcttgg cgattttgct ggtgtttctt 1020961 atacttagaa aattattcac aagatatttt tttaacctgc tttttaattt gacaaaccgg 1021021 ccgaaaacag aaatttttaa acaggtggtt ctggcgtttg ataagccggc cagatggttt 1021081 tttgttgccc ttgggctgtt tttagcgatc cggtattcac cgtttttaga tgagcaaatg 1021141 ccggtcatca gcaaaatata ccgctcactg attgtggcgc tcttgtgttg gggtctttgt 1021201 aatttgaccg caacatcgtc gtttatcttc cataaggtga accagcgctt cgagcttgac 1021261 atggatgaca ttctggcccc gtttttatcc aaattgctcc gttttgtgat cattgcgctc 1021321 agtgtcagtg tgatcgctca ggaattcaat tatgatgtca acggatttgt agcgggcctt 1021381 ggtcttggcg gactggcttt tgcgcttgcc gcgaaggata ccatcagcaa cttcttcggc 1021441 ggtattatca ttattactga aaagccgttt acaattggtg actgggtgga gacgtcgaca 1021501 gtaacaggat cagtcgagga tattaccttt aggagcacga gattcagaac agcacagggg 1021561 gcgcttgtaa cggtgccgaa ctctacgctg tcgatggaag cgatcacgaa ctggacaaga 1021621 atgaccaaac gccagattac gttttccatc catgtgtcct acgctacgcc gattgagaac 1021681 cttgaacgct ccattcattc tctcagaaca atgctcttag agcatgaggg cgttgataat 1021741 gaaataatca tggtcaactt tgatacgttt gccgacagct actacaattt attttttaac 1021801 ttctatacaa aaacgacggt ttgggctgaa aaccttaata ttagagagga tatcaactat 1021861 aaaattattg agattttagg tgcagaaggc gttcagtttg catatcccgg ccaaatggtt 1021921 gttgtcaagc aaaagcacga aagcgaccaa ttccaggtga atctaaataa agaggaaaag 1021981 gaacgggctt aaaagagaga cttcgtctga cagaggcgga gtctttttca tggtaaaata 1022041 agagaaaaag gcggtgttga gttggaaaca ttcaaaagta ttctacatga agcacagaga 1022101 attgttgtgc tgaccggagc gggaatgagc acagaatcag ggatccccga ctttcgttca 1022161 gcagggggca tttggacgga ggatgcctca agaatggaag cgatgagcct tgattatttt 1022221 ttaagttatc cgcgtctgtt ttggcccaaa ttcaaagaat tgttccagat gaaaatgagc 1022281 ggcagctttg aaccgaatga aggccatttg cttttagctg agctggagaa gcaagggaag 1022341 caggtcgata ttttcacgca aaacattgac ggtcttcata aaaaagcggg gagcaggcat 1022401 gtgtacgaac tgcatggttc tatccagaca gcagcttgtc cggcatgcgg cgcccgatat 1022461 gatcttcccc atttgctgga gcgggaggtg ccggagtgca cggcggccgg aaacaatggg 1022521 gacatttgcg gaacggtatt aaaaaccgat gttgttctct ttggcgatgc cgtcatgcac 1022581 tttgacaccc tttatgaaaa gctggatcaa gcagatcttt tattggttat cggcacgtct 1022641 ctcgaagtgg ctccggctag atttgtgcct gaggatgcaa gcctgattcc cggcatgaag 1022701 aaagtcatca taaaccttga accaacgtat tgcgacagct tgtttgacat ggtcatccat 1022761 caaaaaatcg gcgagtttgc ccgaagtttg ggcatgaaaa agtgagccgc tttatgcgcc 1022821 tcactttttt attcatgaac aggaaccatt gtgtcctcta acactccgaa ggaatagcct 1022881 ttttctttta atttattgat tagtaccggc agcgcattta cagtagcagg aagatcatgc 1022941 atgagaatta catttgggcg gcttgaagag ctgtgttcca tattctcaag ctgctgtaat 1023001 acggcggtca catactgtga attccggtat ttccagtcca tgctgtcgat cgtccaatcc 1023061 cagtacacaa acccatcttt ctccagattg cgaatttgtg aggcggttag tgacggcttg 1023121 cttccgtatg gcgttctgac aagatcggtt ttatatcctg taatgtcctg cagcgtgtca 1023181 cgcgcctcct gcatttcttt tagcggagat gtcggtgttt gatagaacaa tctgttattg 1023241 tgggtaacgc catgtaaacc gagtgcgtgg ccttcctttt ctgctctttt cacagcctgc 1023301 ttgaattcgt tcatccgcgg tgacagcata aaaaacgtcg cttttacatc agcgcttttc 1023361 agtacgtcga gcaagcgggt tgtaacggct gaagggccgt cgtcgaaggt taagtaaacc 1023421 gttttatctc ccatgttctg ctttgtctgc agatgtttta tcaggagatc gggggagtcg 1023481 tttttcagct taaggctttc cttctcatct cgaagctggc cgtttgttgt gacagtgact 1023541 tcctttgctt tcgttgaact gttggaataa cccaaaatca ccataagcaa aagcagcaca 1023601 cataaaactg ctaaacttgc aaatttaaaa gcaagcgaaa ctgcagaagg agaagcctct 1023661 cctctcgttt gtcgcataac aatctctcca ttggcataaa atctctacat aatgctgtac 1023721 agcaggcagc ttatgaagat gccttatgtt tacaacctat gtattaccag tcaagtatac 1023781 aggaataaaa ctggaaagca catagaaaat ttgtcgaaat gtcagatttt aaggaaaaaa 1023841 taaactcctt tccgctatag atctcttgat ctttctgttt ttcagcttgt ccaatatggt 1023901 agaattagtg ataatgacag cttgaatgac atcagggaca tctcgaaaag ggagggcttt 1023961 tatgaaggtt ttagtcaatg gccggctgat tgggcgcagt gaagcatcaa tcgatttgga 1024021 agatcgcggt tatcagtttg gtgacggcat ctatgaagtg atcagggtgt acaaaggagt 1024081 attgttcggc ttacgtgagc atgcagagcg ttttttcaga agtgctgctg aaatcggaat 1024141 ttcactgcca ttcagtatag aagatctcga gtgggacctg caaaagcttg tacaggaaaa 1024201 tgcggtcagt gagggagcgg tatacattca gacaacaaga ggtgtggccc cgcgaaaaca 1024261 ccagtatgaa gccggcctcg agccgcagac tactgcctat acgtttacgg tgaaaaaacc 1024321 ggagcaagag caggcatacg gagtggcggc cattacagat gaggatcttc gctggttaag 1024381 atgtgatatc aaaagtctga atttactgta taatgtcatg acgaagcaaa gggcctatga 1024441 agccggagca tttgaagcca ttttacttag ggacggcgtt gttacggagg gtacatcctc 1024501 taacgtttat gccgttatca acggcacagt gcgaacacat ccggctaatc ggctcattct 1024561 caatggaatt acacggatga atattttagg actgattgag aagaatggga tcaaactgga 1024621 tgagactcct gtcagtgaag aagagttgaa acaggcggaa gagatcttta tttcgtcaac 1024681 gacggcagaa attattccgg tcgtgacgct cgatggacaa tcgatcggaa gcgggaaacc 1024741 cggaccggtg accaaacagc ttcaggctgc ttttcaagaa agcattcaac aggctgctag 1024801 catttcataa atgaacgaag aaaagagccc gctttttaca gcggggctct ttttattttt 1024861 taacaaatcc aatcaaaatg gagatcattg gcgatatata gaggaagaac gtaaatggga 1024921 tgtagtctat gactggaaca ccaagtgcgc tcgccataaa tgcgccgctg acgccccaag 1024981 gaatcaatgg gttaattaat gttccgccgt cctctaatga tcttgtcaga aattttcgct 1025041 ggatgtttcg tttgtcatat aaagatttaa atgattgtcc cggtattaat atcgataaat 1025101 actgttcgcc cgttgccaag ttgacgccga tgcttgagca gacagttgct gcaacaagac 1025161 ggccttttga gcggatgcct ttcatgacgc cttccaatag tgcagaaatc aatccgattt 1025221 tctccatcaa tccgccgagt gcaaaagcaa tcataatgag agagacagag cccatcatgg 1025281 attgcagtcc gcctctgtta ataattttag cggctgcctc attgtcagtt tcgaaagttg 1025341 tgccattttg taaagctgtc ataaacgcct gcaggctgct gtagggtaca aaaatagcag 1025401 tcaaaattcc cgaggaaata attccggcag tcagaacggg gattactgat acccgtttca 1025461 ttgccagcaa aacgactaag agcggagaaa gaagggccca cggtgtcacg tttgcagcat 1025521 cttttattcc ggttatgacc tgctgaatat tatcggttga agcagcgtcc gctgacactg 1025581 atgaaccgag aaagtaaaac agaacgacag tgatgagcaa agctggaatg gttgtgccca 1025641 tcatatggcg aatgtgttca aagattggta tttcgcctat tccggctgca aagttggttg 1025701 tgtccgacat cggcgacatt ttatccccaa aacaagcgcc gcatatgact gcgcctgctg 1025761 tccattcaag cggaacgcca gccgcgctcg ccacgccgat cagcgctact ccgattgtgc 1025821 ttacagttgt cagacttgag ccaacaagtg tgctgatgat catacatgaa aacaaagcag 1025881 tcaacagaag gtggcttggt tcaataaagg atagggcata aactgtcata gtcggtattg 1025941 cgccgctgta catccaggcg ccgattaaga tgccgatcag cgctagaaca ataatcggct 1026001 gtacgccgtt tttgatcccg tctacaatcc ctttttcaat gctcttccag ggaaatccaa 1026061 accataaagc tgctgctgaa agcatgacaa cacttaaaaa cagcgggata tgaggttcta 1026121 catgaagcaa gaataagcaa gaaataataa tgcacaacat gaatataaat aaaccgacgg 1026181 ctaacggaaa cgtcagcttt ttttgagaat ccaaaataac accccatatt tatctttaat 1026241 gcttttgtgc ttttgggcac gaaagcatta taacagaaaa aaacgaaaat ctatgttttt 1026301 tcacaattat gaatataaaa gaagtgagca cagggcgtgc tcactttaca atcaggacgg 1026361 gtatatccga tttcgctgaa agcttttcac ttacacttcc gaatattagc tttttcagcc 1026421 tgttttggtc tctgcttccg gttacgatca tatcggcaga aatgcggttt gcatgctcga 1026481 taattgattc agccggatcg ccttctaata tatcgatatc tccatctgcc tgctgttcat 1026541 tcagcatcat tctggcttcg gcgatgactt cttccgtacg gtcttcatag atcattggct 1026601 caggtgatgt tacatccgat atcagcggat caggaacact tgtcatgcct ccgctgatat 1026661 agcttgcctc agctgcgggt ctgggcgggt cgatgacggt ctgattgtct ttcatatcat 1026721 gtgaatgggc gacggtaata gcggcattta cggttttagc aagatcaatg gctgtcagaa 1026781 gcgctttctt actattttca cttccgtcaa acgcaacaat gatacggtca gcatggaaca 1026841 tccttctcac cctttcaaag cgtcttacaa cactactacc cgaatttgag cacaattaac 1026901 cttttcctat tcaagtaatg attgacaata aaaggttttg tttatatgat gataaaaaga 1026961 tgaaatcaga atggaaggag ggtttgctat gccaaggaat ttgcgtgttt atcaaacagt 1027021 ttcatattgg cgcggcaaac cttttgttct gttttcgtga acggtttttt aggtcggacc 1027081 gcgcgctgaa aagcgctgtg cgtaacatat cggttaaaaa aggcatggag ctgacgcttc 1027141 atgccttttt tatatacaaa atctaaggaa agacaggtgt atgggatgtg aagacaaata 1027201 cagaggcgag ggcagttcgt gccaaactgg atgaaaaaag ctgcaaggaa aaaatagaag 1027261 gcggctgatg aggagatggg gatagatgtt ttcagttttg aaaaagcttg gctggttttt 1027321 taaggcgtac tggctgcgct atacgattgc gattgtcctt ttattagcag tcaatgtcat 1027381 tgaaatgttt ccgcctaagc tcttggggaa cgccatagat gatatgaaag caggggcatt 1027441 tactgcggaa gggctgctgt tttatatcgg tatctttttt gtgctgacgg cggccgtgta 1027501 tatcatgtct tatttttgga tgcatcagct gtttggcgga gcgaatctga tggagaaaat 1027561 tcttcgtacg aagctgatgg ggcatttgct gactatgtcg ccgccgtttt atgaaaaaaa 1027621 ccgaacaggc gatttaatgg cacgagggac aaatgatctt caggccgtca gtttaaccac 1027681 agggtttggc atcttgacgt tagttgattc tacgatgttt atgatgacga tctttttgac 1027741 aatggggttt ttgatcagct ggaagctgac ctttgccgcc attatcccgc ttccagtcat 1027801 ggcgattgca atcagtctat atggaagtaa aattcatgag cggtttactg aggcccaaaa 1027861 cgcgttcggg gcgctgaatg acagagtgct ggaatctgtt tcaggcgtgc gggtgattcg 1027921 cgcgtatgtt caggaaacaa acgatgttcg ccggtttaat gaaatgaccg ctgatgttta 1027981 tcagaaaaat atgaaagtgg cttttattga ttcactgttt gagccgacgg taaaactgct 1028041 tgtcggcgca agctatctga ttgggctcgg ctacggagcg tttcttgtat tccggaacga 1028101 gctgacgctt ggagagttag tgtcctttaa cgtttatctc ggcatgatga tttggccgat 1028161 gtttgcaatc ggtgaactca ttaatgtgat gcagcgcggc aatgcgtcat tagatcgggt 1028221 aaatgaaact ctttcttatg aaacggatgt gacagatcca aaacagcccg ctgatcttaa 1028281 agagcctgga gatatcgttt tcagtcatgt cagctttaca tatccaagct caacaagtga 1028341 caatcttcag gatatttcat ttacggtgcg aaaagggcag actgtcggga ttgcaggtaa 1028401 aaccgggagc ggaaaaacga caattattaa gcagcttttg cgccagtatc ctccaggtga 1028461 agggagcatt acattttcag gtgtaccgat tcagcaaatc cctcttgacc gtctccgcgg 1028521 atggatcgga tatgtgcctc aggatcattt actgttttca cggactgtaa aagaaaatat 1028581 tttatacgga aaacaggatg caactgataa agaggttcag caagccattg ccgaagcaca 1028641 ttttgaaaaa gatttgcaca tgcttccgtc cggtctggag acaatggtcg gtgaaaaagg 1028701 cgtggcactg tcaggcgggc agaaacaaag aatttcgatc gcgagagcac tcatggcgaa 1028761 tccggaaatc ttgattctgg atgattcact ttccgctgta gatgccaaaa cagaggctgc 1028821 aattatcaag aacatcagag aaaaccgcaa aggaaaaacg acatttattt tgacacaccg 1028881 attatccgcg gtagagcacg ctgacctgat ccttgtgatg gacggcggcg tcattgctga 1028941 gagaggcacg catcaagaac tgctggccaa taatgggtgg taccgggaac aatatgaaag 1029001 acagcagctg ttcactgcgg aagaaggggg agcaggggca tgaaaatagg aaaaacgtta 1029061 tggagatacg cacttcttta tcgaaaattg ctgatcacag ccgtcctttt gctaactgtt 1029121 gccgtcggtg cagaactgac tgggcccttt attggcaaaa aaatgataga cgaccatatc 1029181 ctcggcattg agaaaacatg gtatgaagct gcggaaaaag ataaaaatgc cgttcagttt 1029241 cacggcgtct catatgtcag agaggaccga ttgcaggagc ctgtttcaaa agcaaaagaa 1029301 gcgcatattt atcaagtggg aatggcgttc tattttgttg atcaggctgt cagcttcgac 1029361 gggaatagaa cggtttctga cgggaagctg acgatcacaa acggagacaa gagccgggca 1029421 tatgctgccg aaaagctgac taagcaggaa cttttccagt tctatcagcc ggaaataaag 1029481 ggaatggtgt tactgatctg cctgtatggg ggcttgcttg tgttttcggt attctttcaa 1029541 tacggacagc attatctgct gcagatgagc gccaatcgga ttattcaaaa gatgaggcag 1029601 gacgtgtttt cgcacataca gaaaatgccg attcgctatt ttgacaacct tccggccgga 1029661 aaagtcgttg cgcggattac caatgatacg gaggctatta gggatttata tgtcacagtg 1029721 ctttcaacat ttgtgacaag cggaatctat atgttcggga tattcacggc tttgtttctg 1029781 cttgatgtga agcttgcgtt tgtatgtctg gcaattgtgc cgattatctg gctgtggtcg 1029841 gtcatatacc ggagatatgc gtcatattac aaccaaaaaa tccgctcgat caacagtgac 1029901 attaacgcaa aaatgaatga gtcaattcaa ggcatgacca ttattcaggc tttccgccat 1029961 caaaaggaaa caatgagaga atttgaggaa ttaaatgaat cacattttta tttccaaaac 1030021 aggatgctga atttaaactc cttaatgtcc cataatctgg tcaatgtcat ccgcaatctt 1030081 gcgttcgtct gtctgatctg gcattttggc ggtgcgagcc tgaatgcggc ggggattgtt 1030141 tctatcggtg tgctgtacgc gtttgtcgat tatttgaacc ggttatttca gccgatcaca 1030201 ggcatcgtca atcagttttc aaagctggag cttgcaaggg tctccgccgg gcgtgttttt 1030261 gaactgcttg aagaaaagaa tacggaagaa gcgggtgaac cggcgaagga gcgcgcgctg 1030321 gggcgggttg aatttcgtga tgtgtcattt gcgtatcaag aaggtgaaga ggtattaaag 1030381 catatttcct ttactgcgca aaaaggcgaa accgtagcgc tcgtcggcca taccggatca 1030441 ggaaaaagct cgattttgaa tcttctgttt cgtttttatg atgcgcaaaa aggtgatgtc 1030501 ttaattgatg gaaaaagcat ttacaacatg tcaagacagg aactcagatc ccatatgggt 1030561 attgtgcttc aggacccgta cttattctcg ggcacaatcg gatctaacgt aagtctggat 1030621 gacgaaagaa tgactgaaga agaaataaaa aatgcactgc ggcaagtcgg tgctgagcct 1030681 cttcttaaga agcttccgaa gggcattaat gagcccgtga ttgaaaaagg cagcacgcta 1030741 tcctctggag agcggcagtt aatttctttc gctagagctt tggcgtttga tcccgcgatc 1030801 ttgattttag atgaggcaac ggcgcatatt gatacagaga cagaggccgt gatccagaag 1030861 gcgcttgatg tcgtcaaaca aggacgcacc accttcgtca tcgctcaccg gctttcaaca 1030921 atcagaaatg ctgatcagat tttggttctt gataaaggag aaattgttga gagagggaac 1030981 cacgaggaac tgatggcatt agaaggccaa tattatcaaa tgtatgaact gcaaaaggga 1031041 cagaaacatt ccattgcata acgctcaaaa acccaaaaca atcgtgtttt gggtttttgg 1031101 tttatgtagt caataagcca gtccgacacg gtttccgaca tactcacctg taacgagctc 1031161 acgatataaa aagtccgcag tatcgccgac cgaaatgctt gtgccgccct caggcaaaac 1031221 gttacgctcc gtacgataaa cgccggttgc tgttccgtcc gggaggtaag tggggcagat 1031281 gattgtccag tctaatgatg attctttaag catttcgtat acttttgcat gctccttggc 1031341 tgcgcgggtc tgctttcgtt tcgattcatt tgtttcaaac cggtattttc ccggttcata 1031401 tcgggaatct aggatccctg cggtgccgat cgtaataagc cgtttgatat gctgttcctc 1031461 cataacggag agaatgtgtg ccatagcagt tgacaaggta tcatcaccat ctgtgcctag 1031521 acagctgatc acgatttcag cattctccat tatttttttc acatcttcta agcggcgggc 1031581 gttccccatg acagttctgt cttttgaaag gggaagatca gcatgttgag atctgatcag 1031641 agcgaaaata tcaaatcttt catctgctgc agcttgtgtt aaaaaggctt gtccgacgcg 1031701 gccgctggct cctaataaag cgattttcat taaaaaacct cctcgccttt cattataaaa 1031761 ggatgttctc agtttgaaca gcgcgggaaa gaatacctgt acaaataaac agaacgatgg 1031821 gaaacatatt catgaatcat ggatacactt acgaattgaa ccagctccca attcacaatg 1031881 gtgatgaatg acaccccgat tccctccctt tttttctagg atatgtggag caggaaaaaa 1031941 gggtgacaaa ataaagagag cgcggaaacc gcgccctcta tagccatata ttgaattgtt 1032001 attgaactct gccgcccatt tgctgctgag cgaaagatac taaacgtttt gtgatttctc 1032061 ctccgacaga accgttagcg cgagaagttg tgtccgctcc aaggttaacg ccgaattcag 1032121 aagcgatttc aagtttcatt tgatcgatag cctgagctgc gccaggaact agtaagtcat 1032181 ttgaagagtt ttggttagcc atgtgtaaaa tctccttttt atttagtatg gttgggttaa 1032241 ctggagttgc accaatctgt gaacccttct cgggtgtcac tgccgcctcg gcgtaaccca 1032301 atgctttgcc ggcttgttac tacgtattat gttaaaatgg ccggaaaatc atgcggagaa 1032361 ttgtgtggta aatcttgaga aataaaaaaa gcttagccgt ttaggctaag ctagtcataa 1032421 atatgaaaaa gcatcagttc atgtatctcg tttgtaagag caggctcgtc agcgcgggcg 1032481 ggaaacaagt ctccccattc aatctcaccg ctcttatgat agatgccttc ataatgggtc 1032541 cctttataat aaaatgaaat tttccatccg ggcagctttt cttttgggaa caaaggtttc 1032601 cagctgaaat gagaaatcat tacggccacg ctccttacat ttggtatcaa ttgacctaaa 1032661 taaaaacggc ttatgttcat tgtatcattg tttcagaaca tcattgaaga ggcctaaata 1032721 tgcagtttgt cccagctttg gataaagata agcccgcttt attaaaaaag cggacaggtt 1032781 acgaaggcca caatgcttcc ggagatgtga ttgccttctc agataaatat gacgcgtatt 1032841 caaaacttct tcgttttgta agagaatcaa catgatgcaa atttggatga gaaaaaatgc 1032901 ttcggcccgg gcgcgaattc gcttcaaaca tccatacttt accgttctga tcaatgccaa 1032961 aatcgaaacc aatctccccg ataaatccct cgatatgatc atgaaggaca tggcttgcag 1033021 tcagtgccgc tgcagaaagc tttttaatga cctcaactct ttcagcggga tcatcgtata 1033081 cttccgcaag tgtctttaca gtgccgccgt tagaaagatg tgttgtaatg ctgttctttc 1033141 cggaaatttt tacggcgatt gctgtcactg tccattttcc ttttctgttt ttattggtat 1033201 ggacacggaa atccgctggt ttgccttgaa attcgatgag atcaacacct tgctgaatga 1033261 gaaagtcgga cgggttgtga tgtttttgaa attctgcaag gaatgaggcg gcatcggaat 1033321 aatcaattga tgtaaaagtt ttggcgtcat tcgtatgctt taccgtcagg ccgccatctg 1033381 ttcttgtcag ctgataaatg ccggtgccga gtgctccatt tgccggtttg atatagactt 1033441 ttttgtatgc gccacagagc tcatctatca gctccacaga cggtgtcagc tcggatctag 1033501 gcaaaaaggg tgccgttctt ggatcttttt cgagcaattg atgaacgttc catttattga 1033561 aaaacgtttt attaaaccat gggatctgat attcatcgat cagcctcttt tttgtatgtt 1033621 gcaagagaag tgaatcttca atttttcggt tcggcaaacg gtcataaacg acgttcggca 1033681 atggaacgat ttttttctcc cagccgtttt ccctgtaaag gaggccttca atcgtgcctt 1033741 cctcccaatt gatttggtgc gcgccaaaaa cgaagcagta gcccccggct tgctcgtgta 1033801 acgtgacaag tttagaaaaa aagagggaac gatccttaaa tgggcgttca agagatacag 1033861 taaaccctgc cgtaaagatg ccgactaacg gcccgatatg cactgtatga tcatgaatca 1033921 gtatatctgc cctgcttcgg tggggaagca aaagctcatg aaacagattt tcagagagaa 1033981 gcacggtttg ttccagatgc cgtctgtaag caacgtggca tctgacaacc ttcgttccga 1034041 atgcggcatg caaaagtccg tcttgcttca gcgaagaggg cagaaacagg gtgttttcac 1034101 tggttttgtc tatgccgatc aaaaaccgtt taggattcac gcggaagaac tcctttctgg 1034161 ctttgctcag aaaacagata ttggcagcgt tttaggggac aagtgtacag ctgttctttt 1034221 tgctcgggag agacacgcag gattgacttc ctgcctggtt tggaattgat atctaaaatc 1034281 caaattctcc cgtcctttgc aagacatata tcaagaccga gttcaaacaa cggcccatag 1034341 cgctcgtcaa gataatacgg aaccgattgg gtaattgaaa acacatcatc tagtaaaacc 1034401 acttgctgtt ttttcggtat atcttcaaac caggagtcaa atgtcagcgc atcagatccg 1034461 cctgacaaat tggccagcag cccgtgtttg tatccgcgtc ttactgcctt tccgactgta 1034521 ttccattcac ctgcttcgtt tttttccata aacagacgaa tatcacaagg gtattgttcc 1034581 ttatcttgaa tgtttaagta aggctgaagc aaatattgat gctgaagcac ttttttgcac 1034641 catgttttaa aagaagtctg gttggaaaac gtttttgtct gcttatcctt tccgatgtga 1034701 taagtagcag tgatgttttt cttgcccagc ttcaaaagaa tcacgcctct gcctcccgcg 1034761 ccgaatgccg gtttaaggat gcaggctttt tctttggata aaaaggagtg aatttgttcg 1034821 tagcggctca cctttatcgt ttcgggaata tagggattga ttacagagtg ctgctgcaaa 1034881 tcgtgaagga cggtccactt atcgggaaga ccccgcccga taaattccgt tttcggatat 1034941 tttttgagcc actcaacgat tggttttgct ttttgggaat gtgaatcctt gccgtaaaaa 1035001 cagcgatcat aaatataatc tggaatcgcc atttcagttt cgttccatgt gctgctggcc 1035061 gaatgataga ccgatgcttt gacacgcaaa gtgtcaggtg aaatatcaaa tggtgtaaac 1035121 cggatgaaac gtatgccgaa ttcgggtgct cttttggcca gttctgcgga ataatccgct 1035181 tcatgctggc gggataagga cataaaaccg agtgttatca tggtgagact ccccctttta 1035241 ttcaaaagct gccggcgggt gtccgcagct ttacactaaa tacatgtaag acgaacgcag 1035301 ctgacggtat tctactttac agaatacgat tctccacctt gccctattcc aaaagaacaa 1035361 gctgattttc taagaacagg aatttgtctc ctcgtttgct aagtgattgc atgagcctct 1035421 ataatacgta taggtacata atctatatga aaaaagctga agcacagatg gaggaagatg 1035481 aataggaatg ggtattgcag gaacctttat ttttatgatc gtgatcggcg ctgccattgg 1035541 agcggtgacc aatcatttag caattcaaat gctgtttagg ccgtataaag cgtactattt 1035601 gtttgggaaa cgagttcctt ttacgcccgg gctgattcca agacggcgag atgaacttgc 1035661 aaaacaaatg ggactgatgg tagtcaatca tctcttaacc cctgaaggca ttaaaaagcg 1035721 gctcgtctct gatgcagcca aaacgcaggc tcttcgagtg ggggaacagc tgattcaaaa 1035781 gctgtcactt tctgaagtga cagtaaaaga agcgcttgaa aaagccggga tgaagcgccc 1035841 cgaaaaagct gctgatgcat ggatcagcag ctggaccgat gataagctgc atgagctttt 1035901 ccgccaatac ggggaccaat cgttaaaaga gctggtgcct atagaggtgc aggaaaagct 1035961 tgaggaaaaa attccgatga tttcaggata tatattgtca cggagtgtcc gttattttga 1036021 aagtgatgaa ggaaaaatcc gtcttggcaa tatgattgat gactttttaa aagagcgcgg 1036081 catgcttgga agcatggtgc aattgtttct tggcaattca agccttgcgg atcgcgtgct 1036141 gccggagctg ctgaaattct tgcgcaatga ggaaacaaat aaattgcttt ctgatctctt 1036201 aaaaaacgaa tggggcaagc tgagggagta tacgtttaat gaagcagatg aaaaatggaa 1036261 tgcaaaggcg ctcattttca gtttgaaacg aagagtgctg caagcatttt cgactgcccc 1036321 tttcttcaac aatacgattg gcacgcttac cgtccgctat gaatctgagc tgacccagca 1036381 aatgctgccg gcactattag acaaattgct tgaaggtatt tcgtccaacc ttgaaagtgt 1036441 cttaaaacgg ttgcgtcttg aggaaatcgt caaggagcag gtggatcagt tcccggtgga 1036501 gcgtcttgaa gaaatggtgc tgtccatttc aaaaaaagaa tttaaaatga ttacctattt 1036561 ggggggcctt ctcggcggaa ttataggcgc gattcaagca ttgtttgtca tcctttttta 1036621 agaagaaatg gtttttgatt aatgaaagga gctccatagt ctgttatagt ggagtggtat 1036681 gtcaaacggc aatgatgaaa ggagctattt acaatggctg ttaattttta tgatgtagcg 1036741 tatgatctgg aaaatgcatt acgcgggagc gaagaattca cccgtttaaa aaacctttac 1036801 gacgaagtta acgcagatga atcagcgaag cgcatgttcg aaaacttccg tgatgtacag 1036861 cttagactcc agcaaaaaca aatggcagga gaagagatta cacaagaaga agtgacgcag 1036921 gctcaaaaaa cagttgcgct tgtacagcag cacgaaaaaa tttctcagct gatggaagcg 1036981 gagcagcgca tgagcatgct gattggtgaa ttgaacaaaa tcattatgaa gcctttagaa 1037041 gagctttacg gcagtgttga aggctaataa gcaaaatccc ttcttggata agaagggatt 1037101 ttttattcac tcagcaaact tggaaatcca atgaatcttt tacctctcca ttgatgatga 1037161 ctgataatgt atgaattcct ttgtaatgct ttctggtggt taaatcctta aaggattgga 1037221 ttcttgtgta tgacttcgtt tcgttttttc gtatatttgt ttctgttatt ttaaatactt 1037281 tctgatgacg ctggcctctt gcttttacaa aatcaattgc gtactcaatt cttacttttt 1037341 gatccctgtc tgaatgaata tagaaagaaa attcaaggct ttcgccaata actatacgtt 1037401 tgggctggca tgttaaatca tgtagttgta tcgaatcagc attttcataa ccaaaaagcg 1037461 ctaaggcctg tttatcaccc ttttttaata aggtccgata ggcgtgtttg ataatccagt 1037521 ctgtatgggg atgtgttccg taccattgat ctgcgacttt tctcagtaaa tgaggatgcg 1037581 tttttgatat atcattaagg ttgttggcca cgctttttct tacatataaa gactcgtcct 1037641 gcatcagctt ctcaaggatc ggcaatacgg gggaagggtc cgatttcaaa gccggtatcg 1037701 attttcccca tggcaggcgg ggcctgctgc cttcgctcgc aagtcttctc acgtgttcat 1037761 ttttatgctc agaccatgca agcaattgtg caatcatctt ttcttgatct aacagcaaaa 1037821 aaggccttac agcaaattct gaggtcgaat attgcgtaaa ggattccaat gcctttattg 1037881 attcttccca atgcgctaac ccgtactgtt ccacataatc tggaaataaa attccgctga 1037941 gtcctttaaa atgaggggct gtatcccgta aaattgtgag cgcttcaacg tattgttttg 1038001 gcaaagtttc gtataaagaa actgtcacgc ggcgcatccg ctcttttaaa gtgagttcag 1038061 gccagtcctc cagccgtaat gtatccaaga atctgttttt gttaaaatca ggataggatg 1038121 accttacatg atggatcaac tgagatatca gttcttcatt atatatttct tttaaatcag 1038181 ccatataaac accgcttttt cgtttattat ttatattgta tgggaatgta cgttctggat 1038241 caagtgtata gtcctaaaaa ttaacaactg atcctaccac ggatatacaa aagttggtta 1038301 ctttttttag ttaaaaaaac ccttgtcatc ggaaaggaaa actgagataa taacattgaa 1038361 agcgcctaca cttacctatt tcaaatggat acggtcgcat atcatgccgt tatatagagg 1038421 ggataagcaa cagagagtaa gtgttcggag cgcatcattg gtcaaacaag gggttcctga 1038481 tacatgattt ttcgtaaatc gaaataacga tattagggag aatggctgct tcgatcgtat 1038541 cctatcaaca agccatacat aaagtctgct gagccaggct ttttttgctt taagaaaagg 1038601 ttgttctaaa cacagagaca gggtcatatc ctatacacaa gtacagtcat caaggagggg 1038661 gacatctctg tgtcaaaaca attgcttgcc ttaaatatag atggagcgct gcttcggtcg 1038721 aacgggaaga ttcatcaggc aacgaaagac gcgattgaat atgtaaagaa aaaagggatt 1038781 tacgtcacac ttgtgaccaa ccgtcatttt cgctcagcac agaaaatagc gaaatcgcta 1038841 aagcttgatg ccaagctgat cacccatagc ggggcatata tcgctgagaa aattgacgcc 1038901 ccgttttttg aaaaaagaat ttctgatgat cataccttta acattgttca agtgctggag 1038961 agctatcaat gcaatattcg gcttcttcac gaaaagtatt ccatcggaaa caagaaaaag 1039021 gtgaattcga atttattagg gaaagcactc attcatccgt ctgacccgat cttttatcca 1039081 gtccagttcg ttgaatcatt aagcgatctc ctcatggatg agccggtgag tgcacccgtc 1039141 atcgaggtgt acacggagca cgacattcag catgacatta cagaaacgat tacaaaagcc 1039201 ttccctgcgg tggacgtgat tcgcgtaaac gatgagaaac tgaatatcgt cccgaagggt 1039261 gtctcgaagg aagcgggttt ggccctcgtc gcttcagagc tgggcctgag tatggatgat 1039321 gtcgtggcca ttgggcatca gtatgacgat ctgccgatga tcgaacttgc cggtcttggg 1039381 gtagcgatgg ggaatgccgt tccggaaatt aagagaaagg cagattgggt tacaaggtcc 1039441 aatgacgagc aaggtgtcgc ttatatgatg aaggaatatt tccgaatgca gcagcgaaaa 1039501 ggatttcttg ataagttcca catgaaacgt gtgtaaaaaa gccgctcgcg ccctgacagg 1039561 tgcggcggct tttttgccgg attgatttta gcagtttatt tctgtacact aaagaaagtt 1039621 ttgaatctga taaattaggt gatgaagttg caaattaaaa tagaaggcat acatgatgac 1039681 cgcctgcatc ggcctctgca aaatattgca aatttgtttt atgaagagtg cgagcttgcg 1039741 tatggcggag aggagcccgc agattttgtc atttctttag cgttgtcaca aacggatgag 1039801 catgtgacgg tttctggaga agtgaagggt actggcataa aggaacagca tacaaaattc 1039861 ttttctccag acatgactga aaaagaagct tttaagcaag tgaaaaacac aatttcttat 1039921 gtgtatctca atcttcttca ggcgcatacg ggcattacgc agaagtgggg aatcctcaca 1039981 ggaatccggc ccacaaagct gcttcataaa aaactgcaaa gcggaatgtc caaggagcaa 1040041 gcgcatgctg agttgaaaaa agactattta attcatgatg aaaaaatcat gctaatgcag 1040101 gaaattgttg accgtcagct ggcggcagtg ccggatttgt accgagtaaa ggatgaagtc 1040161 agcatttata tcggcattcc gttctgcccg acaaaatgcg cgtattgcac attccctgcg 1040221 tacgctatcc aaggacaggc gggcagagtc ggctcattcc tatggggact gcattacgaa 1040281 atgcagaaaa tcggtgaatg gctgaaggag catgatgtta aggttacaac catttacttt 1040341 ggcggcggga cgccgacaag cattacagcg gaggagatgg atctgctgta tgaagaaatg 1040401 gtccgctcct tcccggatgt gaaaaacatt cgtgagatta cggtggaggc cggtcgtcct 1040461 gacacgatta cagaagaaaa actcgccgtt ttaaacaaat atgacattga tcggatcagc 1040521 atcaatccgc aatcctacga aaacgaaacg ctaaaggcga tcgggcggca ccatacggtt 1040581 gaagagacca ttgagaaata tcatctgtca cgccagcacg gcatgaataa tattaacatg 1040641 gacttgatta ttggtttgcc tggggaaggc gtgaaggagt tcaggcacag tctttcagaa 1040701 acagaaaaac tgatgccgga atcccttacc gttcatactc tttcatttaa acgggcgtca 1040761 gaaatgacga gaaacaagca taagtacaaa gttgccggca gggaagaggt ttctcaaatg 1040821 atggaagacg cggtagcctg gacgaaagag catgggtacg tgccttatta tttataccgc 1040881 cagaaaaaca ttcttggaaa ccttgaaaac gtcggatact ctttgccggg acaagaaagc 1040941 atctacaaca ttatgattat ggaagaggtg cagacgatta ttggcatcgg ctgcggcgct 1041001 gctagtaaat ttattgatcg ggatacaggg aaaattacgc attttgcgaa tccgaaagat 1041061 ccgaaatcgt acaatgagcg cttcgagcac tacacggacg aaaaaatcaa atatttagag 1041121 cagatttttg aaaaaacgac aaagcagcac tgattacagt gctgcttttt ttatccctgt 1041181 ttttttgcgg gctgaacctc aggcttccat ttaaatacct tgttcagcaa gcggtaaatt 1041241 cgttttgatt cctttgtgac aagcggtccc aaaatcgcca gaatgaggac atataatgcg 1041301 gcaaacggct ttaatgtggc cgacagtccg ccggctatcc cgagattcgc aacgataatc 1041361 gaaaattctc cccgcgatac gatcgtcagc ccgatattcg atgaagcctt atgagaaagc 1041421 cctgcgcgtc gtcctgccac cattccggcg ataaaatttc ccagaatggt caaaatcact 1041481 gcacccaacg caagccaaac cgcttcacca agcgaaaacg gatcgatgct gaggccgaag 1041541 ctgaaaaaga acatcgcacc gaagaagtcg cgaaacggaa caacgaggtg ttcaatccta 1041601 tcggaatgct ctgtttctga aaagaccaaa ccgagcagca gcgcgccgat tgcttctgct 1041661 acatgaatcg tctctgaaaa accggcgata aaaaagagtg ctgcgaaaat gacgataata 1041721 aacacttcgt ttgagcgaat gtccaacagt ttgttcaaca gcggcgggag ttttcttgct 1041781 gcgataaaaa acagcagcat ataaccgaag gcgatcaaaa tggacaagag tgcactccct 1041841 acggatgtcg catcacctag tataaggccg gaaacaacgg acagatatac ggcaaggaaa 1041901 atatcttcaa acatgatgat gccgagaatc aattcggttt ccgggttggc ggttcttttt 1041961 aaatcaacga gcacttttgc gacaatcgca cttgacgaga ttgtgatgac gcctgcgagg 1042021 atgaggactt ccagaaagga aaatccggtg ataaacccgt aaagcagtcc gaggctgaag 1042081 ttaatcaaaa tataaatcgt cccgccgacc gcgattgatt ttcctgattt gattaacttc 1042141 ccgacagaga attcgagtcc gagatagaag aggaggaaca gtacgcccat tcgcccgaaa 1042201 aactcgatga tttcactgct ttgaataaat gttagatcaa taatccccat tttcggcgcg 1042261 tgcggtccaa caagcattcc cagcacaatc agaaacggaa taatcgaaaa tttaatttta 1042321 ttggcgatca cactggcgat tgccacaagc acaagtgcag ttccgacttc aaatacaaga 1042381 tggtccatcg gggctcacac gccctctcca gaaagaaaat cgtgaatcag tttcttcaga 1042441 tgctttctct cacctgagag gacaagggtg tcattttctt caataatcga atccgctccg 1042501 ggatttagga gcttttcctg gttgtgtttg ataatcgcaa taacagtgac atcgtaattc 1042561 tggcgaacat caagctcacc gagtgtgcgt ccgatcgatt tggcgccttt ttcgacctta 1042621 aaccattcaa taataagatc gctgaaggcc atttcgatgg actccagagc ttgcggttta 1042681 tagaccatgc ccccgagaat agctgcaatt tgccttgctt cagaatcatc caatgaaata 1042741 tttgaaagaa gctcatccgg gtcccggtca ttaaaccggt aaatttccct tcttccgtca 1042801 tcatgaatga taatcgtcat tttttcgtgg cttcttgttt cgatttcaaa ctttttgccg 1042861 atgcccggca gatcgttttc tttaatattc aatgaaaatc cctccgaatg tagtgttggc 1042921 agtatggggt gagttacaaa taaaacttga gcaaattata ttcggaggta attagactgg 1042981 tatttgacag ggacggccaa agccttttcc agcctgttta tcagcggttc gtcaagtggt 1043041 ttgacagaga gctgcctgac agactgcgcc agcgggctgt actctttgat cagctcagcc 1043101 gggtgcatgc tgcccggcga tggcgttttt gccgattgtg tttcctgcgg atatgaagac 1043161 ataggcacat agctgtcagt gcttgcttca aactgggaag gcagaaccac gtccgaaggg 1043221 ggaaagtaca ccataaataa acttaacaga aaactgatca gcaatttatc catgttcctt 1043281 tcctcccttc tcatcaagat atcccttctt tttcactata taaaacttta tgtttccatt 1043341 caaacaatat gcatttttca gtatctattg accttgaaaa ataaaaaggt ttatttgggg 1043401 atggcgggga atgtatagga gaaagaaaaa agtaagcgca tacatggagg tgcttttaat 1043461 ggagtttgtt caatatgcat gtaatggggc cgttgcagag attatcctga atcggcctga 1043521 tgcccatcac gccctgaatg aacagatgct gtctgaattg aaggaggcag tcgaaatggc 1043581 ggctgcaagc gaggcgctca tcgttctcct gagaggaagc gggaaaggct tttcggccgg 1043641 cggtgatatc aggatgatga cgtcagagca tgaccctgac caatttaaac ggctgatgga 1043701 tacgattgag gctgtcaccc tgaatttata tcagatgaag aaagtgacaa ttgcagccat 1043761 tcatggtgct gctgcgggac tgggcctgag tttggcgctt tgtgcggaca ttgtgctcgc 1043821 tgaaaaaaac gccgttctcg cgatgaattt tatcggcatt gggcttgttc cggacggcgg 1043881 aggacattat ttgctgaaga aaagaatcgg tgaagcaaaa gcgaaaaaac tgatttggag 1043941 cggaaaaaaa ctatctgcct cggaagctgc cgatatgggg cttcttgatg ggacatttgc 1044001 cggagaccct gccgaaggcg caagacccat tatcgaaacc ctgttggcct cccctctttt 1044061 ggcgatgatc gaaacgaaag gtatttttca aagcctccaa attgaagaac tgaaaaaagt 1044121 gctatccctt gagcgcagcg cccaagagag aatgagaagg accaaggatc accaagaagg 1044181 aatccgtgcc tttttagaaa aacgggagcc gaagtttcaa gcgtaacaga tcagccggaa 1044241 agctgatcat ctgtgaaaca aaatcagctt tccggctgca ttgactaaac gatgagtatg 1044301 actatgaagc tctttttctt ttaagagggc ttcaccatgc gtttttgccg cttcttcatg 1044361 ttctgcctcg aattgctcgt ttaccagcgt gttccccgaa ggatcaaata cggtaaggaa 1044421 ataatcagcc atcaggtttc tcctccattt taaggtttat cagtctttct tcatttatat 1044481 tctaaaaagg aaatcaaaat cctttattat gctttatcca aaattagtat ataatgggtc 1044541 agggaaggag gagattcagt gcttacaatt gatcacgtaa cgaagacatt tggagattat 1044601 aaagccgttg acggattgga cttagatatt ccggaacagc aaatgttcgg tctattaggc 1044661 gcaaacggag cgggaaaaac aacaacgttt cgcatgatcc taggattatt aagcattacg 1044721 gagggctcaa tcagctggaa gggccgtcct gtgaattatc atatcagcaa caaaatcggt 1044781 tatttgccgg aagagcgggg cctttatccg aaaatgaagg taagggatca gctcgtctat 1044841 cttgccagat taaaagggat ggagaagcga gaggctgtaa aagagctcgg gacatggctt 1044901 gaacgcttca atattacaga ttacgagaat aagaaggtgg aagagctttc gaaggggaat 1044961 cagcagaaaa tccaattcat ttcggcagtt ttgcataagc cggagctcct gattcttgat 1045021 gaaccattca gcggcttgga ccctgtcaat gttgagctgc taaaagaggc cgtgatctcg 1045081 ctgaaaaaca gcggtgtttc tattttattt tcaagccatc ggatggaaca tgtggaggag 1045141 ctttgtgaga acctttgcat attgcagaaa ggaaaaccgg ttgtacaagg caagctgaag 1045201 gagatcaagc gttctttcgg taaaaagaat gttaccattc actccgatga cgatctgcgc 1045261 tttttgcagt cccatgaagg cattcttcaa tggaaggaaa cggcagacgg cgtcaagctg 1045321 cagattgcca atgaagacat ttctcaagag atttttgcga tgctccaagg aaaagggttt 1045381 atcagaaagt ttgagcttga agagccgtca ctgcatgata tttttataga aaaggtgggg 1045441 gccgtctatg aataaatttt ggatcatgct ttctcataca tacaaaaata agattatggc 1045501 aaaatccttt attatttcga ctgtcatcac ggtgctgctt gttttagttg taacgaatct 1045561 ggagtcgatc atttctttgt ttcaaggtga cgatgcgaaa gaaaaaatcg ccgttgttga 1045621 tgaaacaaac gaattatatc cggttttttc taagcagctg aaagcggtgg atacagacgg 1045681 cgatcttgat gtgaagctgt cgaagcaatc ggaggatgag gtcacaaagc aagtcaaaga 1045741 tgaatcactc gatggcatgc tcatcatcaa acgagatgaa aaagggacca tttcaggaac 1045801 atataaagcg ttaacgattt ctgatgaaag cacgtatcaa acactgcagc aggcgctgac 1045861 gcaaaccaaa acagctgtcg gaacagcgga gctcggcgtg tcgcaggaaa cgattagcag 1045921 cctttatgcg cctgttactg tggggcagaa ggcgctgaaa gaaggggcaa agtctgagga 1045981 agagcttggc cagacggtag ggcttgttta cattatgctg ttcgtcattt atttctcggt 1046041 gattatgtat gccagcatga tagcgatgga ggtcgcaacc gaaaaatctt cgcgagttat 1046101 ggaaatcctg atctcaagta tgccgccgat ccagcaaatg tttgcaaagc tgcttggtat 1046161 cgggcttgtc gggatcacac agcttgctat tattatagga gccggctctc tgtcgcttaa 1046221 gctgaaccaa aagagcgaaa cggcttcatc tgtcggcgga ttccttaatt tgaccgacgt 1046281 atctgcaacc actgtcatct atgctgtcat tttctttttg ctcggatact ttttgtacgc 1046341 gacacttgcc gcgtttctcg gcagtgtcgt cagcagaata gaggacgtgc agcaaacgat 1046401 cacgccgatg acgcttttgg ttgtcgccgg ttttatgatc gcgatgttcg gtttgaatgc 1046461 gcctgacgca ggatttatta cggtaacttc gtttattccg ttctttacgc caatgattat 1046521 gttcctgcgc gtcggcatgc ttgatattcc gttctggcag gcggctgtcg gaatcggaat 1046581 cacactgctc accattgtca tactggccgt tatcggcgcc agaatttata aaggcggtgt 1046641 attaatttac ggcaattcaa gcgcgttcaa agcgatcaaa caagcgctac gtttagcgaa 1046701 aaactgattg gaaaacagcc tggggattct caggctgttt ctttattgac agaacgtgca 1046761 ttcgcaagaa ttcggtgcta aaataagggt acttcatcct ggaaaggagc agaatgttga 1046821 ctgatctaac ctttattcat gcggcagatc ttcatcttga cagcccgttt tacgggatat 1046881 cgcatctgcc ggagccgatt tttgcccgga ttaaagaaag cacgtttgca agcgtgagac 1046941 atatgataga cgccgcagtg agagagcacg ttgatttcat tttgcttgcg ggagatctgt 1047001 ttgatgaagc caatcgaagc ttaaaggctc agctcttttt gaaaaaacag tttgaaagac 1047061 tcagagagtg cggaatttcg gtatacgtca tctttgggaa tcacgatcat cttggcgggg 1047121 agtggacgcc gattgaatgg cctgagaatg tccatatttt ttcgtccgct gttccagaag 1047181 aaaaatcgtt ttttaaagaa ggcaggcgca tagcaagcat ttacggcttc agctatcaag 1047241 ccagagcatt gatggaaaac caagccgccc gctatcggag atcaactgac gcaccgtttc 1047301 atatcggcat gctccacggc acgctgtcag gatctgaagg acacgatccg tattgcccgt 1047361 ttacacatga cgacctcgtg aaaagcggga tggattattg ggcgcttggc catatacata 1047421 aacgccaggt tctatctgcc gagcatccgg cagtcattta cccgggaaac acgcaagcac 1047481 gccatataaa ggagacggga gataaaggct attatctcgt tcatgtgaca aacggagata 1047541 tatcttatga atttcagaga gcgcatgatg tcctgtggga aaaagcggcg gttgatgtga 1047601 cggaggcaaa gaatatgaca gccctcttcc aaatggtgga ggacacgttt tcgaagctgc 1047661 ggaaaaaggg gagccctgtt tgtgtaaggc ttgttttaca agggacggcg ccggaatggc 1047721 tgctggaggc gccaaaaggc accttggatg agtttcttga agctcttcag gaacaagaag 1047781 cggaagagga acgtttcgtt tggcctctta gattggacga tgagacagaa aacgaagcaa 1047841 acctaacaaa ccttgatcct ttttttggcg gtttatttga agacattgat cgcagcgatc 1047901 tgtcagacgt gctggaaggg cttgagcggc atccagtgta tagaaggcac gcggaccggt 1047961 ttagccaaga ggaggtaaag gaaataaaag agcaggcaca gataatattg aaaagacagc 1048021 ttaaggtgct tgatacatga ggcggtgaca gctttgcgaa ttatatcttt acatatctac 1048081 caatacggaa aattttccaa tcggaccttt gacttttccg cctctcctgt ccaagtcatc 1048141 tacggattaa atgaggcagg aaaaacgacg atgatgtcat tcattgaaag catgctgttc 1048201 ggttttccga aaacgaaaaa gtatgaaccg aaaacaggcg gtgtctacgg cggtgttctt 1048261 gaagctgaac atcctgagta tggggtgctg aagatcgaac ggacgaaagg gactgccgaa 1048321 aaactaagcg tgtacacaga aaagggcgaa gtaaagcagg gagatgtttt aaagcagctg 1048381 ttccagggca cagacaggtc gttgtacaaa gccatatatt cgttcgacgt attcgggctg 1048441 caggaaattc acgcctttaa tcgggacaag ataggggaat ttttgctctt ttccagcttg 1048501 tttggtgctg aagccgtatc aaagcttgat tcaaggctga cgaaggaaag cgaaaggctc 1048561 tataaaccaa atgggcgaaa ccctcaattg aatcaggagc tggaaacgct taagcagctg 1048621 gcagttaagc taaaacaggc tgaagcagag gaagcgggct atcatcagct tctcgaggaa 1048681 aaacgaacgc ttgaagcccg ccttgcagcc gcggaaaccg aattgaaaga gacggcggga 1048741 catatccgaa tgattgaggg agcgattgag cgaaagccgc tgctaaatga aaaagcgaca 1048801 ctcgaacagg tgattgcaga atttccggaa cacgcaggac aatttcctgc tgacggactg 1048861 catcagctgg aaaaatatga atcccatctt cacccgaaat cagcacagct tgaggcgctt 1048921 cgggtgaaga tggcggagtt ggacaaacag aggcaaaagc ttatccccga taaagaacta 1048981 ttggcgaaag aaacgctgat acaagagctt tcggcagcgt ttcatatgta ccaatcctgg 1049041 ggagaacagc tggcagccat tcaggcacag ctgcgccaga cgtctgcgca gacagcggca 1049101 gggctggaac agctcaataa aacggatgaa aatgagctcc tgaatatgaa cacctcatat 1049161 gattatgaat ggcagcttca gcaagcggtg cagcaatatg tacaggcaag agacagaaaa 1049221 cggcagcttg acgagacgtt tgaacttgcc cggcaagagc tggaagacgc ggaaaaggcc 1049281 gttcgtgccg cttcgtccgc gattcttgaa aacagccaaa gaaaagataa agaagcagct 1049341 cttagagcat atgatgaaac acaggggcag caccaagagc aagcgaagct cagagaacag 1049401 ctaacgtttt ttgaaagaca gcaggctaaa cagaaaaaga ctgtcattgc agctggtatg 1049461 ttgttcatcg ttctcttttc tctgctgcag caatggattc ccgccataag tttcggcgct 1049521 gcacttattg tgtattggct tgtttcagga aagtcgtctt ctcgaaacag ccgagagaca 1049581 agacagccca tgacggatat ttcaccagca gaagctgaaa tgcttagaga agcgttatgg 1049641 gaggatgacc gcaataagca gcaccttctc acacagcgtg cagcgctcca gcaaaaagag 1049701 gcggcgtatg aaagggtcat ccagcagttt gaacagtggg aagccgaaat ggcgccgtcc 1049761 tttacacagg ttgagcgttt tatgaatgag ctcggattta aggaagatcc atcatttttg 1049821 cttgatgcat acagcttaat gaaggatgtt aaaaaagaag tgaagaaaaa gcatgagctg 1049881 accatagaag caggcaggct gaaaaagcac cggagaacat tcgaagaacg cgtcagtatg 1049941 cttcttcccg tgaatcagag tcaggatatc tccatttcgg acgcccttca cacattgcgg 1050001 aaaaacattg aacgtgaaaa agaaattgag aagcaaaaaa aggaaattga aacagatatt 1050061 cattatacaa aggaacagat gcttgaactt gagcaagaaa tacagtattt ccacgcacag 1050121 attgaacagt tatttgccgc ggctgctgca aaagacagag atgcgttttt tgccatagcc 1050181 gccatcagca ggcaattgaa ggatacggag aacaagcttc atcacgtaaa cgcacagctt 1050241 caaggcgggt acccggagga acttgaactg gcggattcca atacgctttc tgaattgaaa 1050301 gataagcaat ttgttgagaa tgaaagaaaa gagcggctga ctgaggagat cgagcagctc 1050361 cgcagccaaa tcgcactgct ctcagtcaaa caggaacaat tagaggcttc gggaatggtc 1050421 tcagacctca agcttcaaac cgaaatgcaa aaagaacgtg tgaaagaaac ggctaaaaaa 1050481 tgggcctcca tacaaatggt caaacaggtg atcagaaaca aattggagcg gcataaaaaa 1050541 atcgagcttc cgcgccttct ggagacggca ggagaatttt tccgtcctct gactgacgga 1050601 aactaccaaa ccatttattt ttccgaaacg gatgattcga tcatggttat gcatcgcgat 1050661 ggcactgtct atcatgcgga agagctgtca caagggacgt gtgaacagct gtatacagcg 1050721 atccgctttg ctttggccgt tacgcgccag ggtgagtcaa agcttccgtt ccagcttgac 1050781 gacagttttg ttcattttga tcaggaaagg ctgaaacgtg tattacatgt tctgtatgat 1050841 ttatctgaag gcggtaggca gattttgtat tttacatgcc atgagcacgt aaaagatgca 1050901 tttcatagca gccaaatcat ccatttggtg tcataaaaga ggttctatag ctgaaaatcg 1050961 gtatgtgata tactggtatt atgtaagata cggagggagc tttaatagaa tggctaaagg 1051021 gattatgcta catgaggttg gcgaacaggt ggaccagtat ctattgatta aatcctcgac 1051081 gaaagggatt gcaagcaatg gaaaaccgtt tctgacgctg atgctgcaag accagtcagg 1051141 cgatattgaa gcgaagctgt gggatgccaa gcaaagtgat gaagtgacct atgcgccgca 1051201 gacgattgtc aaggtcgtcg gcgatgttca ccattatcgc ggacgcaccc agctgaagct 1051261 aagaaatatc agaccggtaa gcgagcaaga aaacgtcaat attgatgatt ttttagaaac 1051321 cgcgccgatt ccgaaaaatg aaatgatgga taccatcact caatatatat ttgaaatgaa 1051381 aaatccgaat atccagcgaa tcacaaggtt tttggttaaa aaacacgaag ctgagtttat 1051441 ggattatccg gcggctacga aaaaccacca tgagtttgtc tcaggtttgg cgtatcatgt 1051501 tgtctctatg ctgaacctgg cgaaagcaat agcagattta tatccttctc ttgatcgtga 1051561 tctgctttac gccggtgtta tcctgcatga tcttggaaaa gtgaaggagc tgtccggccc 1051621 tgtttccact tcatatacgg ttgaaggcaa tttgctcggc catatttcca tcatggtgac 1051681 agagctttca aaagcggctg aggagcttca aatcgattct gaagaggtgt taattcttca 1051741 gcatttgatt ttgagtcacc acggcaaagc agaatggggc agcccgaaac cgcctatggt 1051801 gaaagaagcg gaaattcttc actatataga caatctggat gcaaaaatga atatgatgga 1051861 cagagcgctt gagcgcgtga agccgggcga gtatactgaa cgtgtatttg cactggaaaa 1051921 ccgttccttt tataaaccga catttcataa ataacttaaa aaggactgat gctgacatat 1051981 tcagctcagt cctttttgat gcgtctttcc cgcacataac tcgtctcatt cccgcatatg 1052041 gttaagaata aagaatctat gcaaaggggg aggagcccgt gttatttttt ccgtggtggg 1052101 tgtatctttg tattgtaggc atcattttca gcgcatataa acttgtggcg gcagccaaag 1052161 aggaagaaaa agtagaccag gcttttattg aaaaagaagg acagatttat atggagagga 1052221 tggaaaagga gcgagaacgc cgcagttctc agcagcatga agaagaaaat caaaaccatt 1052281 ccatcgcata aaaaaagctg tgcggctcaa tgagccgcac agcttttttt attatttaga 1052341 attgcttgaa gatgaagaag tgctgttgct tgttgaagat gtattaaatg tgtctttcag 1052401 atctttatct tttacttcga tgtcagcctt cttcatgact ttttgaacag cttcctgaac 1052461 agctgcgttg tcatttaatt tttgttcaag cacttcagat ttcagttctt ttttcatatc 1052521 atcatatttg ccgcgttctt ctgtcttttt aatgatatgg tagccgtatt gcgttttgac 1052581 aggatcactg acttcacctg tttttaattt gaatgcagct ttgctgaatg tttcgtccat 1052641 ttggccttct tttgcgaacc agccaagatc cccgcctttt gaagcagagc tgtctgttga 1052701 gtattctttc gcaaggtctt caaacttctc gccttttttc agctttttct ctacttcttc 1052761 agctgtcttt ttatcagcaa caaggatgtg gcttgcacgg attttgcctt ttaagccttc 1052821 ccagtactct ttgatatcgg cgtctgttac tttgatgtta tctttagccg ctttttgtgt 1052881 cagcaattca tattttactt gttctttcag gtaatctttg ccatattgct tttcgagggc 1052941 agtatattga tcgccaagct gcgttttgta ttctttcagc ttgttgtcaa tttctttatc 1053001 cgaaacttta tacttcttgt ccaatacttt ttcttgcact agctgtgtca gtacgcttgc 1053061 gccagctgtt ttcttcatgt ttgtgtaaag ctcgcctttt gtgacatcgc ctgcgtctgt 1053121 ttttgcgata acttctttgt cgccgctgct gcaagcactg agagcgagga tgcttgtagc 1053181 agtgatagct gctattgcga ttttcttcat tgttttcaaa cactcctaat cattccaaat 1053241 taaattacct atgcgtatca taacatattg tggctttctg taaaaagatt ttaaataaag 1053301 ggcattcgtc tagtcaaact tttgctgatg acatacttat atattgatca agaaaaggag 1053361 gtatgtaaca tgagcggagg atactctaac ggattcgcgt tgctcgtagt actgttcatt 1053421 ttgcttatca tcgtaggtgc agcttacatc tactaagcag cccgaggatc gcttgcaaca 1053481 taagcgatcc tttattttca ctagcgccta atcgtttcaa acatgaattg cataacatgt 1053541 aattggtaaa taaagcttat tacaggaggt gctatttaag atgggtgaag tatttgcagg 1053601 cggattcgct ttattggttg tgttatttat tttattgatt atcatcggcg cttcttggct 1053661 gtactaatca acataaaaaa gcatagctgc ttaatcagca gctatgcttt ctttcgtatt 1053721 tacactgtaa aggagatctc cacaaacgaa gagatcagta aaattaatat agatacatta 1053781 ataaatcgga ataccttatc ttgccgctct tcaggaatct ctctgacaag gcataatgta 1053841 ttggtgagcc tgtttatgaa atataaaata aacacggcag ccacgataaa atagaataaa 1053901 atgatgggag attccccctc tctctgaact gtcccatatt acattaccaa atatttatta 1053961 aaaaagatag aatgcaaatt gaaaaatcgc caccagcacc agggtttgac tacttttcaa 1054021 caagaatatc caagccgtca gcttcctgat caataaaagc ggttttcggt gcttttatca 1054081 gcttgagagc cagcaggaaa tcaggcagac agtagccggc gtgaatgccc gagatcatgc 1054141 aaaaataatg agcgtgattc ggaaatgcca gtgctgcgta aaacaatacc ggtgtaatca 1054201 gcaagaacgg gctgacgagt gaaatcagca ttgttgtttt tggtatacgt ttccatgtgc 1054261 gcatgcgcaa tatgtaaaac tttttttcta tttttctttt tttgcagatg attggcagga 1054321 catggatgac tttatgtaca aataaaataa cgacgagcaa accgccgaat aaagatacat 1054381 attcatcgct taagcttgtg ccaggccgca gcagctcaaa agctaaaaag gtagatataa 1054441 aaaccaaaat cataaaacat acagcagtta atattatgcg aacggcgcca taatccttca 1054501 tgagatttat ggtcttccag caattcatca aagtcatcct tccatacatc ttgaatagaa 1054561 tctcaaaata atttactcct cccaagagaa aaaatcaatg cttttttaag aaaaaatatc 1054621 atccggcagg tatttttttg aaacaagcaa acaaactgcg aaatatgggg ttagaacttt 1054681 cttctcagtg aattatcagc taaaataaga ttaaagatag aaagaagtgg tgtggatgga 1054741 ttcgatggat catcgcattg agcgattaga atattacata caattattag tgaaaacagt 1054801 agatatggac aggtacccct tctatgcgct tctcattgat aaagggctga gcaaggaaga 1054861 aggggaagcg gttatgagga tatgcgacga attgtcggaa gagctggcaa cacaaaaagc 1054921 gcaaggattt gtaacctttg ataagctcct tgcgcttttt gccggacagc tgaatgaaaa 1054981 attagatgtt catgaaacaa tttttgccct gtatgagcag gggctttatc aagagctgat 1055041 ggaagtcttt atcgacatca tgaagcattt tgattaactg tttacaggtt cgagctcttc 1055101 agccggttca tccgccgcac tgtcctttgc ttttttcttc aattttccgt ttacgctttc 1055161 aaagtcattg tcaatattgg tgagtgacgt ttcgaaaatt tccataaaat catcgccgta 1055221 gatatggcgt atcatacaca tcatttctgc cacttcagga aattttccga ataaatgata 1055281 taaaggctgt gaccctttaa aaacagcgtt gcgtgtcgga tcaaattcct caagcaagct 1055341 ccagaatacc tcggtacctt cctcagtcaa ttggacatat gtgttccgtt tatcattcag 1055401 ccgtttggag aaccttaaat atccccgttc ttccagcttt tttgaaaagt tgaatgcggt 1055461 tgatacgtgc atgaccccga atttcgcgat ttcagaaatg gaagctccat tcaattgata 1055521 cgcaatccat aaaatatgat gctcattaat attcaggtca tacggtttga gccattgctg 1055581 ccaatccttc tcgatcgatt tccaaagagc cttgctaagc tgagccattt tctgggtgaa 1055641 aaccagagct tctttcacat catagggcgg ttccactcga ttcattacgt cacctgcttc 1055701 tctttttctt tttctctatt atgccaataa aataaagatt aataaagatg aaaatgtaag 1055761 aattttttaa taaattcaca aaccattgcg acgaaagggt ttttcggcca aaaaaaatac 1055821 gggtccaatt ttggcccgca tttttttctt ttgaatagga tattagtttt gtaaggtttt 1055881 ctccagctgt ctgattttct cttcgatatc ggcaatttct ttttgcagat cctgctggtg 1055941 aggcttgatc tcttcctgcc attttttaat tgatgtttgg agctcgccgc ccacgtcttt 1056001 aataacatcc gtgctttctt ttgccgcttt gatcagctgg tcttttaatg caagcccgtc 1056061 tgactttaag cgtttgattg tttcttcaaa agaatcataa ttggttttca ttttttcacg 1056121 cagctgcttt cctgaggaag gtgcagtaag aagaaccgct gctcctccga tgatgccgcc 1056181 tacgaatagt cctgttaata gagaacgtcc gctcgccatt acaatcaccc cgtctttttc 1056241 ttcaaaatag gattcattca gcatttttca tttttgttga aagcctgaac ttctatacat 1056301 agcttgcttt attttagcat attttttaag tgaaaaggag ggagaaggtt gtctgtcttt 1056361 ttgattgtat tatcctgcat cacccttgcc ttcgcttcag gcgctgttta ctatatcaaa 1056421 cttctcagcc aggctgcttc ttatccgccc aagagggtta tccggcagaa agcgcttgtt 1056481 tgttcaaccg gaaccgcctt tacactatgt cttatctttt tcacaaaact cctcgcttaa 1056541 aacatgctga catgctgcgg gcgctctgtt caaaaaaacc tctcccggaa gcggaagagg 1056601 ttttgtgtga caattattta gcagcttcca taaagcttga acgccttaaa atggtttgca 1056661 caatcggata aataatgatc attgagattg tattcagcac agcggccggc agaacaacag 1056721 ccgcgaacaa tgcggcgaaa ccgcccggta aaccgacgat caataaagct gacgatagaa 1056781 acacaattcc tgataagatg gtcccgatca ctgtcagcac agcggctgca cctgttttcc 1056841 ggctctttct gaacaagaga aacagggaga agaacagaaa cgctgatacg ggtttatcaa 1056901 tgatgttagg gatctgtccg gctggaaacg cggttgtaag cgcggaaatg attccggtca 1056961 cgatcccgat gacgagtaca ttttgcaccc gcgggaacag cagaatgccc atgaacatca 1057021 tgatcagcat catatctggt ttcatgccgc ctaaaaaggg cggaataatg gaatgaagcg 1057081 ctgcgccgat tgcggcaaac agagccataa tgactaactc ttttgttttc ataactatgc 1057141 tctcctctgc taagcttttt gccctccaat aatatgctca tcatttattg cgaaggcttt 1057201 acagaatgtg ttatgcaaac agtataccaa acggacggtt tgcatagcca gactttttac 1057261 tcattttcct gctggaattt cttcatgaac gcagctaatt tttcacagtc ttcgagagag 1057321 accgcgttat aaatagaagc gcggcagcct cccaccgaac ggtgtccgcc aaggccgatc 1057381 atcttcgcat cttttgcttt ctgaacgaat gttttcgtta attcgtcatc ccgaagcgtg 1057441 aatgtgacat tcatgcgtga gcggctgtct tttctggcat gtcctttata gaagccgttg 1057501 ctttcatcaa tacagctgta gagaacctgc gctttttgtt cattgcgctg ttcaacagct 1057561 tccacaccgc cgttttcctt gagccattcc agaacgaggc tcagcatata aatcgcaaat 1057621 gtcggcggag tgttgtagag tgaatccgct ttgacatgcg tggaatattt caagattttt 1057681 gggacgttcg cattttcatt ttgcagccag ctttttttca tgatgactac agtcacgccg 1057741 gaagggccga ggttcttttg ggcgcctccg tagatcacat caaatttgga cacatcgatt 1057801 tttctgctta aaatatcgct ggacatgtcg gctacgagcg gaattggaga attcggaaac 1057861 tcctgccact gagtgccgaa aattgtattg ttggatgtga tatgtaaata tgcgccgtct 1057921 tttacatccg taaggtcaac ctctggaata taactgtaat tgtctgtttc acttgtagcg 1057981 gtgatagacg tgttcccgaa cagtttcgtt tctgccagtg ctttttcaga ccaagcgccg 1058041 gtcatcacaa aatgtgcggt tttttcaggt gttaaaaagt tcatcggaag cattgagaat 1058101 tgaaggcttg ccccgccttg aagaaacaag atatcgtaat cttccggaat gcccatcagt 1058161 tcgattaaga ggcttttcgc tttttggtgc accgcttcat actctttgct gcggtgggaa 1058221 agctccataa cagacatgcc ggattcgtta aaatcaataa attctttctg tgctttttgc 1058281 agaacttcca gtggcagcgc tgcaggacct gcgttaaaat tcgttgtacg ttccattatg 1058341 atctctccct gttttccacg ttaatgtata aaataataca attatcctat cacaaaaatt 1058401 cagttttttg ataaaaaatt agaattatca aaagaaattg acggatgttt gcgaaatgtt 1058461 cacaaaataa aataacctca tcttatgatg aggccaggcg ttttgcgata gaggaagaga 1058521 tgttctgcag atcctccggt ttataatcat cagcatgcgt tttccaaacc gctccgaatc 1058581 catctccttt tccgtagcga gggataatat gcatatggta gtggaacaca gattgtccag 1058641 ctttttcgcc gttattgttc agcgtattta agccgatcgg ttcaaattca tcccggatag 1058701 cgcgggcgat ttttggaaca gcatggaaat attgttttgc taattcatct gtaaattcat 1058761 atacattctc aatatgtgtt ttcggaatga caagcgtatg gccttttgtc acttggctga 1058821 tatcaagaaa ggcaagtaca tgttcatctt catacacctt cgctgatgga atgtcgccgg 1058881 caataatttt acaaaagata caattctctg cacaatgcat gagggttcct ccttatgaaa 1058941 ttgtttagta tgtatacatt catcgtacca cagaaatgca gaaaatagaa aacaggatga 1059001 acggcgagcg ttcaccctga atgcagagga agagcttata tgaagaaaat gtgttatgcc 1059061 tttggtaagc acctcatttg tcaataaaat gaagacttgt ttaatgccta acgattcctg 1059121 cgataaacac ctcatttgac aatttgcttc atacatgaag aattcatcaa ttcagtgaag 1059181 agaaatggtt tgagcattgg acatgtttat tttctatcca actgtttcta agacgtcttt 1059241 gacaaacacc tcatttttca gttgatatgc ttttcctcta caacttttat gatgtccaga 1059301 accctgtctc tttatgacag caaattcatc atttgttaaa agggaattgt ttcaaatcag 1059361 gccttgtttt tggtactatg aagaaaaaca ctataagggg agaaactatg tctctgctat 1059421 cggtaaaaga cttgaccggc ggatatacaa ggaatccggt tttaaaaaac gtatcattca 1059481 cccttgaacc gaatcaaatt gtcggcttaa tcgggctgaa tggtgctggt aaaagtacaa 1059541 caatcagaca catcatcggg ctgatggacc cgcataaagg ttcaatcgaa ttaaacggta 1059601 aaacgtttgc tgaggatccg gaaggctacc gttcacaatt tacctatata cctgaaacac 1059661 ctgttttata cgaagaattg acgctgatgg agcatcttga actaacagcc atggcatatg 1059721 gactgtcaaa agaaacgatg gagaaaaggc tgcctccgct actaaaggaa ttccgaatgg 1059781 aaaagaggct gaagtggttc ccggcccatt tttctaaagg aatgaagcag aaggttatga 1059841 ttatgtgcgc atttttggca gagcctgcgc tctacattat tgatgagcct tttctagggc 1059901 ttgatccgct tgccattaac gcgctgcttg aacggatgaa tgaagcgaaa aaaggcgggg 1059961 cgagcgtgct gatgtcaaca cacattttgg caacggcaga acgctattgc gattcgttta 1060021 ttattttaca taacggcgag gtgcgggcgc gcggcacgct gtcagagctc agagagcagt 1060081 ttggaatgaa ggacgcggcg ctggacgatt tgtatcttga gcttacaaag gaagacgctg 1060141 gccatgaata atatgcttga tatttggcag tcgcggctgc aggagcatat caaagaaaca 1060201 agaacataca tgaaatatat gctcaacgat cacctcgtca ttgttttgat tttttttcta 1060261 gcgggcgctg caagctggta cagcaaatgg atacgggaca ttcccgctca ctttccgtcc 1060321 ttttgggtga tggccgtgct gttttcgctc gtattgacaa gctcttatgt gcgaacgctt 1060381 ttgaaggagg ctgaccttgt tttcttattg cctcttgaag caaaaatgga gccttacttg 1060441 aagcaggcgt ttgtctacag ctatgtgtct cagctgtttc cgctgattgc gctgagcatc 1060501 gttgcgatgc cgctttattt cgcagtcact ccgggagctt cgctcgtatc gtatgccgcg 1060561 gtctttgtcc aactgttgct gctgaaagcg tggaatcagg taatggaatg gcgaacgact 1060621 ttccaaaacg accgcagcat gaaacggatg gacgtcatca ttcgctttgc ggcgaataca 1060681 ctcgttcttt attttgtttt ccaatctgtt tatatgtatg cgcttctcgt ctatgtcatt 1060741 atggctgttc tttatctgta tatgtcttcc gcagcaaaac ggaaaacatt taaatgggag 1060801 agccatattg agtccgaatt gagacgaaag cagcgtttct atcggattgc caacctgttt 1060861 actgatgtgc cgcatttgcg aaagcaagcc aaacgcagag cttatctcga ctttttgctg 1060921 cggcttgtgc cgtttgaaca gcgcaaaaca tttgcctata tgttcacccg cgcctttttg 1060981 cgttcgagcg attatttggg cattcttgtc agattaacga tcgttttcgc gctgatcatt 1061041 atgtatgtct cagccagccc gctgattgcc gcggttttga ctgtgtttgc cattttcatt 1061101 acgggcattc agcttctgcc gctcttcggt cactttgacc atctggcgct tcaagagctg 1061161 taccctgtgc aaaaagaaac aaagctgaaa agctatttct ctctattaaa aactgcactt 1061221 agtattcaag cgctgctgat gtctgttgca tctgcctatg cagccggctt gaccggtttt 1061281 ctgtacgcgc tgatcggttc tgccgttctg atttttgttg ttttgcctgc ttatatgacg 1061341 accaggctga aaaagcacgg aaagctgtga actgaaaaga ggtaatcaaa tgacagataa 1061401 tcagctgctg atgcaggaag ctttggaatg gaaaatgcat tttttgcgaa aggattccat 1061461 gtttgaacgc ttttcgaagc gtgtccagac gaaggtgaat gaacggattc ctgaaaaaat 1061521 ccatacggtc gtcaccgaga gtgtgaaaaa aatggtagaa gcgacaatgg ccggctctaa 1061581 tatcatcacc tataaaaagg atacaagtgc actgtcgctc agtgaaaaaa acgaattggc 1061641 gaaaaaaacg attgtttctt atcaaaaagt ggcagctgct gagggagtcg gcaccggagc 1061701 gggcggcatt tttttaagca ttgctgattt tccgctgctg ctttcaatta agatgaagtg 1061761 tttatttacc ttgtcttcca tttacggctt tgatgtcaag gatgcacaag aaaggatatt 1061821 tttgctgctc gtgtttcagc ttgcgttttc gagtgatgat ggccgtaagt cgcttttttc 1061881 tgtcatcgaa aattgggaga cggagaaaaa gagcatcgac tggagagtgt tccagcagga 1061941 atatcgcgat tatatcgacg tcgtgaagct ttttcagctt ttgccgggcg taggagcggc 1062001 agtcggcgga attgccaatt ataagctgct tgctcagctt ggagaaacgg caagacatgt 1062061 ttttcatctg aggatattaa aggaaacagc cggagaataa acactccggc tgttttttta 1062121 tagctgatga taggtgatcg cagcgccggc aaggaccttg gccgctgtca gcatggcttt 1062181 ttcgttgata tcaaatttcg gatggtggtg ggaatagact cgctctggct gttcgggagc 1062241 ggcgcctgta aagaaaaaag tgcccttcac gttttgtaag taataagcaa aatcctcgcc 1062301 gcccatttgt ggttcaccgt caatgacctg ctgaacgccc tcggtattct ttgcggtgct 1062361 caccaagtgg ttcgtttctg caggatggtt cacaaccgct ggataaccct gttcataggt 1062421 gtactcatag gacgcgccgt gcatgctgca tattcctttt acaaccgctt caatttcttt 1062481 ctccagaatg tcccggacat tttcatcaaa agaacgcgct gtgccgatga gtactgcttg 1062541 gtctgcgatg acattaaacg gattgtcggc gatgaaggag cctgtcgaaa tgacggcgga 1062601 ttgaatcgga ttgactttgc ggctgacaat gtgctgcaaa gaggaaacga tttgcgaacc 1062661 gattaggacg gcgtctttag tatcatgcgg atgagcgccg tggccgccct ttccgaagac 1062721 tttaatcgta aatcggtctg ccgccgccat tacggcgccg gggcggcaga gaatagttcc 1062781 gagcggctca gttgcccaaa gatgagtgcc gaatatcaca tccgtgtttt cgagacatcc 1062841 gtcatcaatc attggctttg cgcctccagg ataatattct tctgcatgct ggtggatcat 1062901 cacaaatgtt cccttcagtt catgtctgtt ttggtgaagg accttggcca ctgcgagaag 1062961 agctgcggtg tggccgtcgt ggccgcatgc atgcatgaca ccaggcactt tggaggcgta 1063021 agggacatct ttttcatctt gaatggggag agcgtcaaag tcggccctca aagcgactgt 1063081 agggccgggt tcgcttcctt ctatatttgc taaaacccct ctaccgccaa cgtttgtgcg 1063141 gattgggact cctaacgatt cataatagga agcaataaat gcggcggttt tttcttcttg 1063201 aaatgagagc tcaggataca tatgaaaatg gcgcctgatc tcaaccattt cttcaaaaca 1063261 gccgtcgagc tgtttgttta tctctttctg cagtgtggat atggacaaag ccgcttcccc 1063321 cttttctatg cttttccatg attgtataga aaaagtctga atatttcaac tcatgctgtt 1063381 ttaaagcatc atcacagctg cgagggttgt caccaaaagg ccaatcgcga cgggaatgaa 1063441 gttttttctg gcaagctcaa aaggatcaac tttgcaaatg gccgcggcgg gaatcaaagc 1063501 ccatgggacc agtgttcctc cgcccaccca gatggcagag atttgtccga gcgcggtcag 1063561 aatagcggga tcggcatgga gagcggacga aaagagcttt gcgatggagc cggcgagaga 1063621 aatgccagaa aatcctgagc cgtcaaggcc tgttatggct ccagcggcag ttaatgcagt 1063681 ggcggcaagc tcctttgaca taggcatcat atgggataaa gcaatgccaa gatcgttgac 1063741 aatgccgtgg gaacctttag ggagtgaagt gcccagtatg ctttcatagc ctgagtcgcc 1063801 aagataaaag aaagcggcaa tcgggatgac ggggccgaaa accttaaaac cgaacttaaa 1063861 tccgtcaata aaatagccgg tgattttttc aagcccttta tgcttataca cgaaaaaatg 1063921 aacggtaaag aggatacaaa ttgcagaccc gccaattaac gcggttgcat catttccttg 1063981 taggttaaac aagagcatgc aggcgatatc tgcaagaaag gcaagcggaa tcaaaaaagc 1064041 cagtatggac cgcaggcgtt ttggcaagta cagcgagttg tcttgttcgc cggaaagaac 1064101 gggggaaaaa gaagtgggat gctcctgttt tttgcgttcg cgctgaatca tgataaaggc 1064161 agcagttgtt gttgtcacac ccataatcag cacaagcgga atactggccg agacgacatc 1064221 accgactgga atgcctgctg catccgcagt cagctttggc gccgcctgaa tgacaaagtc 1064281 tcctgacagg gcaaaaccgt gtccgaataa gttcatggcc atggccgcgg caagaggcgt 1064341 caaaccggca cgtgcggctg cggggagcag gacggcgccg atcaaagcga cacccggaga 1064401 aggccagaag aatagagaaa tggcgaacat caggcctcca atcagccaat aggcagtcac 1064461 aggccctctc acaaggcttg caaagggaga aatcatcgct tcatttatcc ctgtttttgt 1064521 taacaaatca ctcattgaaa cgataaagca aatgatgaaa atcgtgggca gcagttcgcc 1064581 ggccgcatag ataaagctgt ggaataaact gctgacagaa gctgaaagtg aatggctggc 1064641 ccatagcgat atgataaaaa tgccgaatag agaaataaat gtcgtgtctt ttctcagcag 1064701 cataaatagg ataattgcac cgataaaaaa cacatacaga acatggacag gcaaaatccc 1064761 gacttccatc atcgatcact ccttccgctt acagattatt cataggcggg cggaaggtgc 1064821 cgggacagag gggagggtta tgatggaaga tgaacattga tctgtttcag ctgctcaatc 1064881 agatgatgcc ttaatcctct attcgctttt tgcagatgtt ttgggaagca ttcaggagaa 1064941 aaaatgacgc acccttcagc aagccagttt tttctatagg cgatgatgct ttccgatggc 1065001 tctatatgag ttatcctcgt gctgcatctc gtactcatca aatccgaact gaaaaccgca 1065061 gcacgggcag atttcatgag aatgattgcc ttcatgatca tatggcggtt cagccaatcc 1065121 ttaaacccgc agactgggca agtatgcttc attttgcttt cctcccaata aaataagctg 1065181 ccggacatgc cggcagctat tcgacagcga aatatgtggt gacataggaa ggccgggaga 1065241 agatcgacgt tgtgtcaatt ccggcagatg tatcgcgttt tttgtgggct tctttgtaag 1065301 aaccggactg ctgccagtct tgaaaggcgc tttccgtttc ccacaaggtc agaatgacat 1065361 aggtgtcact gtcaagcgga cggagcactc gaattgcttc aaagccaggc tcgttttcga 1065421 cttttcccgc tctgttttta aatctgtttt caaacagcgg acgcccttcc tgagtaacgg 1065481 caatattgtt caatactgca aaaccgggat gtttgatctc tccgacttgg tcaatgactt 1065541 cataagcgtg tggtgcctgg aaaacggtat ctccgtttgt ttcatgaatt aaaatggcgt 1065601 tttcctgccc ctgcatcaaa aggatatttt ctgagggatg cttctgtacg atcgttttta 1065661 aaaaatcggc tgtcccatat gtaatataaa ccttcatatc agccacctcc tgcttgctag 1065721 tatatcaaaa caatggtata agtttctatt ggcgagtgct tcgaacataa ttccaaacaa 1065781 tttttcccat actaccttta gaaaggcgag gtgagttcat gtttaagata aagaaaaaga 1065841 aactttttat acctatcatt attttagtgt taactgcttt tctcgcttta ataggatata 1065901 tttcaattat ttttctcggc cattatgtca tagatgaaaa aaagcttatt cttcatgctt 1065961 cttcaaaaat tgttgatcaa aacggagatg aggttgcaag cctgtataca gaaaatcgcg 1066021 agccggtctc gatcaatgag attcctaagc aggtcagaga agcgtttatc gctgttgagg 1066081 ataaaaggtt ctatgagcat cacggcattg atgcaaaatc cgtcggaagg gcagtgtacc 1066141 gcgatatatt agcaggcgga aaggtggaag gcggaagcac gatcacccag cagcttgcca 1066201 aaaatatttt tctgacacat gacaaaacat ttctaagaaa aacaaaagaa gtgatcattg 1066261 cgattaatct tgaacgggat tacagcaagg acaagctgct tgaaatgtat ttaaaccagc 1066321 tttacttcgg acacggggtt tacggcatac aagcggcgtc ccactattat tttaataaag 1066381 aagtaaaaga tttgactgta tctgaaggcg ctgttttggc cgctattccg aaggcgcctt 1066441 ctacgtactc tccaattttg caccctgata aaaataagga gcggcgtgat acaattctag 1066501 gtatgatgaa tgaccaaggc tatatcagtg cgaaagaggc tgtcaccgca cagggccgga 1066561 cgcttggact gcatgtgaag aaacagtcgg aaacaccttg gtttgacagc tacattgacc 1066621 ttgtgatcaa agaggcggaa gacaagtatt ccatttccgg agagcagctt cttcaaggcg 1066681 gatacacgat caaggtgccg ctcgattcga agctgcagaa gacggcttac caggtgatga 1066741 aagagggaag ctattatccc ggaacagatc agaatgccga gggaagcgcg gtctttatta 1066801 ataacaagac aggcggtgta gaagcggcca tcggcggaag ggattacaca tccaaaggat 1066861 ataaccgtgt cacagctgtc cgccagccgg gttccacatt taagccgctt gctgtatacg 1066921 gaccggcgat gcaggaaaag aaatttaagc catattctct attgaaggat gagttgcagt 1066981 cctacggaga ttatacgccg aaaaactacg acagccggta tgagggcgaa gtcactatgt 1067041 ctgacgccat tacgtacagc aaaaacgcgc cggctgtctg gacgctgaat gagatcggcg 1067101 tcgaaacagg gaaatcttat ttgaaagcaa acggcattga tatccctgat gaaggccttg 1067161 ctcttgctct aggcggcttg gaaaaaggcg tttcaccgct ccagcttgcc ggcgcgtttc 1067221 atacatttgc cgcgaatgga acgtatactg aacccttctt tatctcgagc ataatagatg 1067281 aagacggaga aacaatagcc gatcataaag aagaaggaaa gcgggtattc agcaagcaga 1067341 cgtcttggaa tatgacgaga atgctgcagc aggtagtcaa aaagggaacg gccacgtccg 1067401 gcacctatca cggcgacctg gcgggaaaaa caggttcaac atcttataca ggcgtctccg 1067461 gcgcgacaaa ggacgcctgg tttgcaggct atacgccgaa aataaccggg gcagtctgga 1067521 tgggctatga caaaacggat caaaaccatt atttgaaagc cgggagctca tacccgacgc 1067581 ggctgtttaa ggatattttg acacaggcag gagaaaccgg tcatgtgttc acaaagccta 1067641 aaaacgttaa agaactggaa agcccgattg agctgaagcc ggtcaaaaca ctcacagccg 1067701 attacacatt taaagcagcg gggctcttta ctattgaatt aaagtgggac gctcaagagg 1067761 atgatcgggc cgtatacaga atttatgtaa acaaggacgg cgaggagacg cttcttgatt 1067821 cggttgaagg gaagggaagc tatgaaattc cttatgccaa cttattttcg ggcgcgtctt 1067881 ataaaattgt gccttataat acacagacaa aaagagaagg ggaaggaacc gattacgttc 1067941 agccaaaatt gttttcctct taatggaatt cggcgatttt ttgaactttg agctacattt 1068001 ctataccatt tgcctaaaac aaggtatagt gtaataagtc aagaaatacg aacgtatggt 1068061 tgccgtatga aaggtggaaa tcagatgagt aaacgagaaa cgtttaacga gacgttttta 1068121 aaagctgcgc ggggagaaaa agcggatcac acgcctgtgt ggtatatgag gcaagcaggg 1068181 cgctcacagc cggaataccg caagctgaag gaaaagtacg gattgtttga gatcacacat 1068241 cagcccgaac tttgtgcgta tgtcacaaga ctgccggttg agcaatacgg agtcgatgct 1068301 gcaatccttt ataaagatat catgacgccg ctgccgtcaa tcggtgtgga tgttgaaatc 1068361 aaaaacggga tcggtcctgt gattgatcag ccaatccggt ctctggcgga cattgaaaaa 1068421 ctcggccaga ttgatccgga acaggacgtg ccgtacgtgc ttgagacgat taaactgctt 1068481 gtcaatgagc agctgaacgt cccgctcatc ggtttctcag gtgcgccttt tacgcttgca 1068541 agctatatga tcgaaggcgg cccgtcgaaa aactacaata aaacaaaagc cttcatgtac 1068601 agcatgccag atgcatggaa tctgctgatg tccaagcttg ccgacatgat catcgtgtac 1068661 gtgaaagcgc agattgaggc aggcgcaaaa gcgattcaaa tctttgattc gtgggtcggc 1068721 gcattgaatc aggcagatta cagaacatac atcaaacccg tgatgaaccg gatcttttca 1068781 gagctcgcaa aggagaatgt gccgctgatc atgtttggcg ttggcgcaag ccatcttgca 1068841 ggtgattggc atgaccttcc tctcgatgtt gtcgggcttg actggagact cggcattgat 1068901 gaagccagat caaaaggaat tactaaaaca gtgcagggca acctggaccc gtccattttg 1068961 cttgcgccat gggaagtcat tgagcagaaa acgaaggaaa tacttgatca gggtatggag 1069021 tcagacggct tcattttcaa tcttggccat ggggtatttc ctgatgtcag tcccgaggtt 1069081 ttgaaaaaac tgacagcatt tgtccatgaa tattcacaaa acaaaaaaat gggtcaatat 1069141 tcctaagcat atcttttggt atcttaatga tatcctgtca aaatgtttgt atcagatcat 1069201 taaagagggt gtaaacagtg agtagaaaga aaatggggct tctcgtgatg gcgtacggca 1069261 cgccttataa ggaagaagat attgaacgtt attatacaca tatcagaaga ggcagaaagc 1069321 ctgaacctga aatgcttcaa gatttgaaag acagatacga agcgattggc ggcatttcac 1069381 cgcttgccca aatcacagaa cagcaggcgc ataatctgga acagcacttg aatgaaattc 1069441 aggatgagat tacgtttaaa gcgtatatcg gactgaagca tatcgagccg tttattgaag 1069501 acgccgtagc agagatgcat aaggatggca ttacagaagc agtcagcatc gtgctggcgc 1069561 cgcatttctc cacgttcagc gttcagtcct acaacaaacg cgccaaagaa gaggctgaaa 1069621 aactcggcgg cttaacgatt acgtcagttg aaagctggta cgatgaaccg aagttcgtga 1069681 catattgggt tgaccgagtg aaggaaacat atgcgtcaat gcctgaggat gaaagagaaa 1069741 acgcaatgct catcgtatcc gcacacagcc tgccggaaaa aatcaaagaa tttggagacc 1069801 cgtacccgga ccagcttcat gaatcggcga aattaattgc tgaaggcgca ggcgtttccg 1069861 aatatgctgt cggctggcaa agtgaaggga acacgcctga tccttggctc ggacccgatg 1069921 ttcaggattt aacacgtgat ttattcgaac aaaaaggcta tcaagcattt gtatatgttc 1069981 ctgttgggtt tgtcgcggat cacttagaag tgctttatga taatgattat gaatgcaaag 1070041 tggttactga cgatatcggc gcaagctatt accggccgga aatgccaaat gccaagcctg 1070101 aatttattga tgctttggca acagtcgtat taaaaaaatt aggacgttaa agaaggcgat 1070161 gaacatgagt gacggcaaaa aacatgtagt catcatcggc ggcggcatta ccggtttagc 1070221 cgccgccttc tatatggaaa aagaaatcaa agaaaagaat ctgccgcttg agctgacact 1070281 tgttgaggca agtccgagag tcggcgggaa aatccagact gtcaagaaag acggctatat 1070341 catcgaaaga gggccagact catttctgga acgaaagaaa agcgccccgc agcttgttaa 1070401 agacttaggt cttgagcatt tgcttgtcaa caatgcgacc gggcaatcct atgtgcttgt 1070461 aaaccgcacc ctgcatccaa tgccgaaggg cgctgtaatg gggataccga caaaaattgc 1070521 gccgtttgtt tctacgggtc tgttttcctt gtccgggaag gcgagagctg ctatggattt 1070581 catcctgcct gcaagcaaaa caaaggatga tcagtcattg ggagaattct tccgcagacg 1070641 tgtcggagat gaagtggtcg agaacttaat cgagccgcta ctatcaggga tctacgcagg 1070701 cgacattgac aagctcagcc tgatgtcgac atttccgcaa ttttatcaga cggaacaaaa 1070761 gcatagaagc ctgattctcg gcatgaaaaa aacaaggcct caaggctcag gccagcagct 1070821 gacggcaaaa aaacaagggc agttccaaac tctgtcaacc ggtttgcaga cccttgtaga 1070881 agagatcgaa aagcagttaa agctgacgaa ggtgtataaa ggcacaaaag tgaccaaact 1070941 tagccatagc ggctcttgct attcgctcga actggataac ggcgtcacac ttgatgctga 1071001 ttcagtaatt gtgactgctc cgcataaagc ggctgcggga atgctttctg agcttcctgc 1071061 catttctcat ttgaaaaata tgcactccac atccgtggca aacgtcgctt taggtttccc 1071121 tgaaggctcc gtccaaatgg agcatgaggg cacgggtttt gtcatttcaa gaaacagtga 1071181 ctttgcgatc acagcctgta cgtggacgaa taaaaaatgg ccgcacgcag cgccggaagg 1071241 caaaacgctg cttcgggcat atgtcggaaa agccggagac gaatccattg tcgatctatc 1071301 agataatgac attatcaaca ttgtgttaga agacttaaag aaagtcatga acataaacgg 1071361 cgagccggaa atgacatgtg taacccgatg gcatgaaagc atgccgcagt accatgtcgg 1071421 ccataagcag cgtatcaagg agctgcgtga agcacttgca tctgcgtatc cgggtgttta 1071481 tatgacaggc gcttctttcg aaggtgtcgg cattcccgac tgcattgatc aaggaaaagc 1071541 tgccgtgtct gacgcgctta cctatttatt cagctaaaac ctccgcttta tcgcggaggt 1071601 ttttttgatg tgcaatggca atattgtgta aaaaatgatt gaattgaaca gcaggttatg 1071661 atacatttgc atatgtactt aatgactaaa atgttcaaac ggtcagtttc gaggtgaata 1071721 caatgtcaat agatcgaaaa aagctcattt tggaggcggc tacaaagtct ttcacgcagt 1071781 tcgggtataa agcgacgaca atggatcttg tcgcaaaact tgcgaacgtg gggaagggaa 1071841 ccatttatac ttttttcaaa aacaaagaag agctgtttga cgagattttc actactttat 1071901 taaaggaaat gaagcaaaaa gcggatgaag cgatggagcc gagccttccg ttccatgaaa 1071961 atgtgcacag agcgctgttt gccattctgg agttcaggaa aacacatcag ctgacgatta 1072021 aaattttcca agagaatgcc gagattggta caatggcagt tcaggaagtg atccagaaaa 1072081 tggagcgatc catcctgtct tatatcaaaa gcaagattga agacgggatc aaaagcggcg 1072141 caatcaagcc gtgcgaccct gagctgacag cctttgtgat gctgaagctt tatatcgcgc 1072201 tcatttttga ctgggaaaaa caacaccccc cgcttgataa agagacaatt gcgggactgc 1072261 ttgaattgta tgttgtcaaa ggattgtcag cgaactagat aatcctttct ctttgcaaga 1072321 aaatgaccat tttttatgat gagtcagttt tagaatggag gcatcaggat gaacacaata 1072381 cgaagtcagt ggaaagacat cgtaacaagt aaaaaattat tgattcccat catcgccatt 1072441 ttgtttgtcc cgcttattta cagcggcgta ttcttaaagg cttattggga cccgtacggc 1072501 acagttgacc agctgcctgt cgttgtcgtc aaccaagaca agggagcaac gtatgaagga 1072561 gaaaaacttc aaatcggtga tgatctggtc aaagaattaa aggataataa caactttgat 1072621 tggcattttt ccaatgatct cgaccaatcg ttaaaggact tattgaatca aaaatattat 1072681 ttagttgtcg agattcctga ggatttttct aagaatgcca gcactgtatt agacaaaaat 1072741 ccgaaaaaat tggatctgaa ataccataca aatgcaggtt ctaactatgt aggggcaacg 1072801 atcggcgaaa aagcgattga taaactgaaa gcctctgttt caaaagaagt gaccgagcaa 1072861 tatacgaaag ttatttttga taactttaaa gatatcgcaa aaggtttgag cgacgcgagc 1072921 agcggcgcga aaaaaattga tgacggcaca aaggatgcga aaaacggaag cgcccagctg 1072981 aaagaaaatc tggcgaagct gaaggaaagc accgctacca tcagtgacaa aacagcgcag 1073041 cttgcagatg gagcggctca ggtgacgagc ggcatccaat cacttgacag ctcgctcggt 1073101 aaattccagg acagcagcaa ccagatttat gataaatcta gtcagcttgc agcaggatca 1073161 ggcgagctga caagcaagat gaatgaactt cttgccggac ttcaaaatgt gcagaagggt 1073221 acgcctaatc ttactaacgg gttggatcag ctcaacagta aagtccaaga aggttctgag 1073281 aaagcggcaa aagcggaaaa gatcattaat gcgctcgatt taacgaagct tgaaactgct 1073341 gtaaacaatc tggaaaagtc agaaactgcg atgaaggaat tcaaaaaaca gctgactgac 1073401 tttgaaaaca gtttgaaaaa ccgtgatcag gcatttaaaa atgtcatcaa ttcgagtgac 1073461 ttcttaacag cggagcaaaa aagccagctg attaattctg ttgagaaaaa gcttccgcaa 1073521 gttgatgcgc ctgattttga tcaaatatta agccagctac ctacagctga tcagctgcct 1073581 gacatcgcaa cgataaaaag ctctcttgaa gacgtgaaag cgcaggtggc gcaggtgaaa 1073641 gccatgccgg aagctacatc taagctttat aacggcgcaa aaacaatcca agatgcgatt 1073701 gacagattaa ctgagggagc tgataagata tacaacggtt ctcagaagct gacagatggc 1073761 caaactaaac tgacagcggg catcggtgaa tataataagc agttcgcaaa agcaaaagcg 1073821 ggctcagagc aattggtgac aggaagcagc caagtatccg gcggattgtt taagctgtta 1073881 gacgggtcta aacaggtcca aagcggatca tcaaaacttg cagacggatc tgcatcactt 1073941 gatacaggtt taggcaagct attggacggc acaggagagc tgtctagtaa gctgaaggat 1074001 gcggctgacc aaacaggaga tatcgatgct gatgatcaaa catacggcat gtttgcggat 1074061 ccggttaaaa ccaaagatga tgccattcat tccgttccta actatggaac agggctgaca 1074121 ccttatatcc tgtcaatggg cttgtatgtc ggcggcatca tgctgacggt tgtcttcccg 1074181 ctgaaggaag cgtcaggacg tccgagaaac ggttttgagt ggttcttcag caaattcaat 1074241 gtcatgatgc ttgtaggaat cattcaatca ttgattgtgg cgacggttct tctattggga 1074301 attggtcttg aggtagagag cacgtggaga ttttacgtgt ttacgatcat tacgagtctc 1074361 gctttcctgg cgataattca atttttggct acaacgatgg gcaacccggg gcgatttatc 1074421 gcagtcatta ttttagtgct gcagctggga gcgagcggag gaaccttccc gctggaattg 1074481 cttccgaatt tctatcaggt catccacggc gcattgccga tgacctacag cattaacgga 1074541 ttcagagcag tcatttcaaa cggtgacttt ggctacatgt ggcagatggc cggcgtctta 1074601 atcggcattg ccctcgtcat gattgcacta agcattactt actttacaat gttaagccgg 1074661 aaggaagaaa catcagaaga acagccggct tcataaagaa aaagaacttg tttccttgga 1074721 aacaagttct ttttttgtta catcccccat ttaataagca atcctgtata ggttaatccg 1074781 ccgccaaacc cgaaaagcaa aacgatttga tcttttttca gcttcccggc tttcactgcg 1074841 agatcgagcg ccaaaacaat tgaaaccgaa gacgtgtttc cgtagtgctc aacactagtg 1074901 agcgtttttt caatcgggaa cggtgttttt tcacaaattg actcgatcat gcgcaagttg 1074961 gcgctgtgag gaacaaacca atcgagatca tcggagctga gtcctgcttt atgtaaaagc 1075021 cgttcaaatt cgccagggac ggttcttgcg gcccatttat atacctcgcg tccgttttgc 1075081 accatttttc cggaaccgac aagctgcaca ccgtttattt catttcgcag tccggcacga 1075141 tacaaaatat cgccgccgtt cccgcttgtt ccttgtacag acgcaagaaa tcccggcgtc 1075201 tcttcatctc gttctactaa cagcgcaccc gcggcatcgc cgaacagtac gcatgtcgtt 1075261 cgatcggtat aatcggttac ctttgataac gtctctccgg cgatgacgag aattttttga 1075321 tgaaggccag atgtgatcaa tccatttgcc aaatggaggc cgtatgtcag cccggcgcat 1075381 gtcgcattaa tatccagcgc gccggtgctt tcccagccga aatattcctg tacgcggcat 1075441 gccgtactcg gaaaggcgta atcggatgtg gttgtggcaa cgaggatcat atcgacatca 1075501 tcaagcgttc ctttataacg gctcttgaga ttcttcaccg cttctatgca taaatcagag 1075561 gtaaattgat gttcatccgc aatccggcgt tctctcattc ctgtgcgctg aacgatccat 1075621 tcatcagagg tatcaacgat cttttctaaa tctgcattgg ttaaacgtct gctcggcgca 1075681 taggtgccga tagctgtaat ttttgctttt gacatatgaa tcactcctta tggtcagatt 1075741 ataacactag atattagtat ctggtactaa aaagaaggtt tttttacaaa aaaagagaag 1075801 tgtagatagg aatctatgaa aaagaaaaag gaggctgaaa aatggtcagt caagaagcag 1075861 tagtcttttt ggcattatcc ggggctattg cgtttctgtt gccaatcggg ctgattgtat 1075921 ggtttaagcg aaagtatggt gcctcgctta aagtgttttt tattggcgct ctcacgtttt 1075981 ttgtcttcgc tcagctgctg gaaggcggcg ttcatgttta tgtactgcaa gtgaatgaaa 1076041 tgacgaaaga agcgatgcag catccattat ggtatggcat ttacggctgc ttgatggccg 1076101 gcatttttga ggagtgcgga aggtatttga tgatgcgatt ttttatgaag cgccatcata 1076161 cttgggcaga tggtctggct ttcggggcag gccatggcgg gcttgaagcc atcctgatta 1076221 caggcttgtc ctctatctca cttattgtat acgcatttgc aatcaatagc gggacgtttg 1076281 aacagctttt ggtcaatggc gacgtcaaac aggcgctttt gccgatacag gagcagctgc 1076341 tgcatactcc ttcgtatgaa tggatgctgg gcggaataga aagaatcagt gccattgccg 1076401 tccagattgg tctgtctctg cttgttttgt acgcggttaa aaaccgccgg ccgctgtttt 1076461 tgctgtattc tattctttta catgcactgt ttaatgtccc ggcggtttta tatcaaagag 1076521 gaatcataga gcatgctgca gctgttgaaa tcattgttgc tcttatagcg gctttatcag 1076581 tttattggat tgtaaaagca aaaagggtgt ttcaataaaa ggtccaagca gcagcaatgc 1076641 ccgcttggaa aaatgtgaat ggaaatattc attaagcatg ggtcatcaga atatttctga 1076701 ttcagtcttt agcaatgaca gcaagaatgt ctgtgttttt tacaagagaa acaatggtgt 1076761 ttctttttct tcttctcgca agggtcatgg cattctttct ttttcttgca atggtcgtgg 1076821 aaatctttat cgaaccactc gtcaaagaac caaaaatcat cgaaccaatc gtgacaacga 1076881 catttctgtt catgtgaatg acgacagcac atagaaatcc ctcctcttcc catgctctct 1076941 acagcatatg agagattgat aggaaaagat tggacgggtc cctcgggaaa agagtatatt 1077001 ttaagtagaa aataaaagga ggaatgccct atgacgtccg tacgtaaaac gatggagctc 1077061 attaaagaac ttgtatcgat cccaagcccg acaggaaata catatgaggt gatcaattat 1077121 attgaaagcc ttttaaaaga atggaaggta gaaacggttc ggaaccacaa gggcggctta 1077181 attgcaacgc ttccaggacg cgacacatcc cggcatcgca tgctgacagc gcacgttgac 1077241 accctcggcg ctatggtgaa ggaaattaaa gcggacggcc ggctgaaaat cgacttaatc 1077301 ggcgggttcc gctacaactc gattgagggg gagtattgcc aaattgaaac cgcctcggga 1077361 aaaatgtaca caggcacaat cttaatgcat caaacgtctg tgcacgtata caaagacgcg 1077421 ggaaaggctg agcggaatca agagaatatg gagatccgcc tagatgaacc tgttcactgc 1077481 cggaaagata cggaggagct tggcattggc gtcggagact ttgtgtcgtt tgatccacgt 1077541 gtcgagatca catcaagcgg atttattaaa tcgcgccatt tggatgacaa agcaagcgtc 1077601 gccttattgc tccgcttaat tcatgaaatt caaacagaag acattgagct gccgtataca 1077661 acccattttc ttatttccaa taatgaagaa atcggttacg gcgggaattc gaatattcct 1077721 cctgaaacag ttgaatattt ggcggttgat atgggcgcta tcggtgacgg gcaggcgacg 1077781 gatgaatatt cagtatcaat ctgtgtgaag gatgcgagcg ggccgtatca ttatcagctc 1077841 agaaagcatt tagttcaatt agccgagaag catcatattg actataagct tgatatatat 1077901 ccgtactacg ggtctgatgc gtcagcagcg atcaaatccg ggcatgatat tgtgcatggc 1077961 ctcatagggc cgggaattga cgcttcccat gcatttgaac gcacccataa atcatctctt 1078021 cgccataccg ctaagcttct gtattactat gtacagtcac caatggtata agggggagga 1078081 ccaatgaaga tttataagct gaaaagcaca ttcggttggg aaggtgatga cgggttggga 1078141 gaacagctga ttcagcagat ccttgccgga gaaaaaagcg ccacgtgcgc gccgaaatca 1078201 ttgtattcaa aagatgaatt gagggacgtt tatcaaacag cgggtcagct tgttaccgtt 1078261 tatgataaac atgacaatcc aagatgcaat ataaaagtaa cagatgtctt tgaaaccacc 1078321 tttggtgcgc ctgatatgag gttagtcaaa ggagagggca atggagaccg aattgaggag 1078381 tttcaagagg atcatcggat ggcatgggcg gaactgatca aaagcggtga actggagctg 1078441 aatgaggata ctgttttgat tacagagttg tttgtgcttg ttaaagatta aaaaagcctg 1078501 cggggcaaga accccgcagg cttttcatta accagaaatg gttgcgtttt gttctgtttt 1078561 cgattgggac ataacagttt ctgctttcgc aggattaaac atgccttccc atttagacat 1078621 cacaacggca gcaagcgcgt taccagtcag gttgacaact gtacgtgcca tatccatgat 1078681 gcggtctacg ccggcaataa aggcaagtcc ttcagccgga acgccgatgg tgccaagcgt 1078741 tgcaagcaag acaacaaaag aagtaccagg tacggcagcc atccctttgg atgtcaccat 1078801 taagacgagc acaagcgtaa tttggtgcca aatcgtcaaa tcaatgccat atacctgtgc 1078861 taaaaagagt gcggcaatag attgatagag aacggaaccg tctaagttaa acgtgtaacc 1078921 gatcggaatg acaaatgaaa caatgccttt tggacatccg attttctcca ttttttccat 1078981 gatacgcgga agaaccgttt cagagctgga cgtactgaac gccagtaaga tttcgtcctt 1079041 catgtaagca aggaacttga agatgctgat gccggcaatt tttgcgacaa tcccgaaaat 1079101 aacaattaag aagaaagcaa gcgcgacata aaccaatccg acgagctttc cgagagagat 1079161 aagagaaccg agtccgaatt tagacacagt cactccgata agagcgaaaa cgccgaatgg 1079221 cgccactttc atcacaaggt ttacaacgtg gaacatggca tgggatacac cttcaaaaaa 1079281 ggctaataca ggcttgcctc tttcaccgat cgcggaaata cccaatgcaa atagtactgt 1079341 aaagcagatg atggctagaa gatccccttc gaccaatgac tggaagaagt ttgtcggcac 1079401 aatatggagg aacgtttccg ccactgattt attactttgt tctttttcag tttcaacata 1079461 ttgactgatg tccgattttt gagcttcgtg tatattaact cctgtacccg gatggaagat 1079521 gtttgcaagg gctagtccga gaataatggc aaaagtcgtg atgatctcga agtacagaat 1079581 cgttctgaag cctaatttac cgacttgctt tccatttcct gcaccggcta caccgatgat 1079641 taagctggag acaacaatag gaatcactat cattttgatt aagcgtaaaa agagatcccc 1079701 gattggctgc aggtaagtag gcaatgctgg gttgccatac caaatgacgc caacaatgac 1079761 acctagaata agtccaacga atatttgtgt ggctaatcca aacttaattc ttttcataga 1079821 ttacctccca aaaaacaaag tatcaacata tatcatgaat agacatatat ttaatctcac 1079881 tattagatca aattataata gataagaaat caattcgtct atagtaaatt atatttcgaa 1079941 aataaagaat attcaatgac attatgataa tcaccagaat tatctaaaaa caggtgagct 1080001 ttgacctaac ctgactatta tttcaaaatt aagagatatg tgaaaaaata agaaaatccc 1080061 acgcgtaagg cgcgggattt tcgctcatta caaatcgttt acttttatac agtcattgca 1080121 gatattacca taacactcat gctgctcttc tatctttttt ccgcattccg cacacttttt 1080181 cgaaggcagg tttctaaaaa attctgtgat tttccccagc ataaccaatc cctctttccc 1080241 ctttgtagtg atttcattgt aatataacag attacaaaaa tcaataactg ttttgataca 1080301 atgtttaaaa catgcttttt tcaagaaaaa tgggtatatt gaaggaggac caattttttt 1080361 gaaaagatag gaggacatta tgaaagttac agttatcgga tgctatggcg gttttccggc 1080421 cgcaaatgaa gcgacgtcag gctatttgtt tcagtcaggt gattactctc tgcttgttga 1080481 ttgcggcagt gccgtattgt ctaagctgtt cggatatgtg ccggcggaaa agctggatgc 1080541 ggtcgttctg tctcattatc accatgacca tatcgctgat atcggaccgc tgcaatttgc 1080601 caagcaagtc ggttcgtttc tcggcaaagg agagcatacg cttccgattt acggacatga 1080661 tgctgatata gaacagtttc aaaagcttac atataaaaca catacaaaag ggatcgccta 1080721 tcagccggat cagccgctga ctgccggtcc gtttacgatc acctttttaa aaacgattca 1080781 cccggtgacg tgctatgcca tgcggattac tgacggcagc cacactgtcg tttatactgc 1080841 tgattccagc tatcaggatt catttatacc gttttcgaaa gatgctgatt tattgatctc 1080901 agaatgcaat ttttatgccg atcaagacgg aacaagtgca ggccatatga acagcctgga 1080961 agctgggcgc attgcaaaag aagccggagc gggagaactg ctgctgacac atttgccgca 1081021 ttttggcgtg catgacaacc ttcgcaaaga agcgaaaacc gtttttaacg gagaagtgaa 1081081 tattgcgaaa tcaggttttg tgtgggaagg ataaaggagg agcaccatgt tatttataga 1081141 caatcaaaat atcaatgatc cgcggatcaa tcttgctatc gaggagtact gtgtaaagca 1081201 tttagaccct gaacagcaat atttgctctt ttatgtgaat caaccgtcta ttatcattgg 1081261 gaaaaaccaa aatacaatag aagaaatcaa tacaaaatat gttgaggaaa acgggattat 1081321 cgtcgtccgc cgtttatcag gcgggggcgc tgtgtaccat gatctgggga acttgaactt 1081381 cagctttatt accaaggatg acggggacag ctttcataac tttaaaaaat tcactgagcc 1081441 agtgattcag gcgttacatc agcttggggt tgaagccgaa ttaagcggcc ggaacgacat 1081501 tgtagtagat ggccggaaaa tatccggaaa cgctcagttt gcaacgaaag gccgtatttt 1081561 cagccacggc accctcatgt ttgattcagc cattgatcat gttgtatcag cattaaaggt 1081621 gaaaaaggat aaaattgaat caaaaggcat caaatcgatc agaagccgag tggcaaacat 1081681 cagtgagttt ctcgatgata aaatgaccac cgaagaattc cgcagccatt tgcttcgcca 1081741 tatttttaac acaaacgacg ttggaaacgt gccggagtat aagctgacgg aaaaagattg 1081801 ggagaccatt catcaaattt cgaaagagcg ctatcagaat tgggattgga actacggccg 1081861 ctcaccaaaa tttaacctta atcattcgaa gcgttatccg gttggatcga tcgatttgca 1081921 cctggaagtc aagaaaggca aaatcgagga ctgcaaaatc ttcggagatt tcttcggtgt 1081981 cggtgatgta tctgaaattg aaaacctgct ggtcggaaaa caatacgaac gcagcgtcat 1082041 cgctgatgtg ctcgaaggtg tgaatctcaa gcattacttt gggaacatta cgaaagagga 1082101 tttccttgat ctgatttact aaggcaaaac acatcgtttg aaagagcggt tgtgtttttg 1082161 aaataatgga ggcaggaggg attcacatga aagtgttttt aatcggagcg aacggacaaa 1082221 tcgggcaaag actcgtctct ttattccaag ataatcctga tcattccatc agagcgatgg 1082281 tcagaaaaga agaacagaaa gcgtctcttg aagctgccgg tgcagaagct gtgcttgcga 1082341 atctggaggg cagcccggaa gaaatcgccg ctgcggcaaa aggttgtgac gcgatcattt 1082401 tcacagccgg ttccggcggc agcacaggct atgataaaac gctgctggtg gatcttgatg 1082461 gagcggcaaa agccattgaa gctgcggcca ttgccggaat caaacggttt attatggtca 1082521 gcgccctgca agcccataac cgtgaaaatt ggaatgaggc actcaagcct tattatgtgg 1082581 ccaagcatta tgctgataaa attctggaag cgagcggttt aacctatacg attatccgtc 1082641 cgggaggcct tcgcaatgag cctggaacgg gaactgtttc agcagcgaag gatctggagc 1082701 ggggatttat ttcccgtgat gacgttgcaa aaacggtcat tgcctcttta gatgagaaga 1082761 atacggaaaa tcgggccttt gatctgacag aaggagatac gccgattgcc gaagcattga 1082821 agaaactatg acagtactga cactcagggc tttttgctct tgagtgtttt tttctgtttc 1082881 tctataatgg agaagaaagc ttggcttcaa taatgaatga ctattcattc acttaagggg 1082941 tgggagaatg aatcttgttt caaaattgga agaaacagca tctgagaagc ccgacagcat 1083001 cgcatgcagg tttaaagatc acatgatgac gtatcaagag ctgaatgaat atattcagcg 1083061 atttgcggac ggccttcagg aagccggtat ggagaaaggg gaccatttag ctttgctgct 1083121 tggcaattcg cctgatttta tcatcgcgtt ttttggcgct ttaaaagctg ggatcgtagt 1083181 tgttcccatc aatccgttgt acacgccgac agaaattggt tatatgctga caaatggcga 1083241 tgtaaaggca atcgtgggcg ttagccagct tttgccgctt tatgagagca tgcatgaatc 1083301 gctgccaaag gttgagctcg tcattttatg ccagacgggg gaggccgagc cggaagctgc 1083361 ggacccagag gtcaggatga aaatgacaac gtttgcaaaa atattgcggc cgacatctgc 1083421 cgctaaacaa aaccaagaac ctgtacctga tgataccgcg gttattttat atacgtcagg 1083481 aacgactgga aaaccgaaag gcgcgatgct gacacatcag aatttgtaca gcaatgccaa 1083541 cgatgtcgca ggctatttgg gaatggatga gagggacaat gtggtctgcg ctcttcccat 1083601 gtttcacgtg ttttgtttaa ccgtctgtat gaatgcaccg ctgatgagcg gcgcaactgt 1083661 attgattgag cctcaattca gtccggcatc tgtttttaag cttgttaagc agcagcaggc 1083721 gaccattttt gccggtgtgc ctacaatgta taactacttg tttcagcatg aaaacggaaa 1083781 gaaagatgat ttttcttcga tccggctgtg catttcggga ggcgcgtcca tgccagtcgc 1083841 gttgctgacg gcgtttgaag aaaaattcgg tgttaccatt ttggaaggct acgggctctc 1083901 ggaagcatca cccgtcacgt gctttaaccc gtttgacagg ggcagaaagc cgggctccat 1083961 cgggacaagt atcttacatg tcgaaaacaa ggtcgtagat ccgctcggac gcgagctgcc 1084021 cgctcaccag gtcggcgaat tgatcgtgaa aggccccaat gtgatgaagg gctattataa 1084081 aatgccgatg gaaacagagc atgcattaaa agacgggtgg ctttatacgg gggacttggc 1084141 aagacgggat gaggacggct atttttacat tgttgaccgg aaaaaagaca tgatcattgt 1084201 aggaggatac aatgtgtatc cgcgggaggt ggaggaggtg ctgtacagcc atccggacgt 1084261 caaggaggcg gttgtcatcg gcgtgccgga cccccaaagc ggggaagcgg taaagggata 1084321 tgtggtgccg aaacgctctg gggtaacaga ggaggacatc atgcagcact gcgaaaagca 1084381 tctggcaaaa tacaagcggc ctgccgccat tacgtttctt gacgatattc cgaaaaatgc 1084441 gacggggaaa atgctcagac gggcactgag agatattttg ccccaataaa atgaaaaagc 1084501 gaagcggtta gcttcgcttt ttcattttca atcctttgct tcttttttaa taatatttag 1084561 cagcgccttt gtatcatttt tgcttaattt gtagtatgtg ccatccttca aaaaaacggc 1084621 ttgctggctg ccgtcaatcc atagtctgaa tgagtcatac cggtctttat gaaacttgat 1084681 tgtcccttcg taatcagggg ctgatgtttt ttctgtcttc acctgttttc cctgattcat 1084741 aatatccagc atatctttga cgtgctgtct tttttcaatc tcgatatctt cctggccgct 1084801 tgaagacagt gtgatcaaat ccgcgtctac cgattgatac acatcgcctg atcggctgta 1084861 aagataaaaa aatgcgataa acacaagacc gattaccacg atggctgcca ctattttttt 1084921 catttgcatc actccaaaca ttgttagttt tcccagcgat cggggtttcc atgcttaaaa 1084981 gggtggaaaa gtgcggaaca cagcttggtt ctaagaattt gaatttatga ttacaataga 1085041 agtaacgggt tgatgtgagg agtgaggcgt tatgcgcaag tggattgcgg cagcaggact 1085101 tgcttacgtg ctgtacgggc tgttttttta ttggtatttt ttcctgtcgg gtgattccgc 1085161 aataccggaa gccgtgaaag ggacgcaggc tgatccggct tctttcatga agccgtctga 1085221 gttggcagtg gccgagcagt attcgaatgt caagaatttt ttatttttta tcggggtacc 1085281 acttgattgg tttctgtttt ttgttctgct tgtcagcggt gtttcaaaga aaatcaagaa 1085341 atggatcgaa gcggccgtgc cttttcggtt tttgcagacc gttggttttg tgtttgtgct 1085401 ttcgctgatt acaacattgg tgacgctgcc tttagattgg ataggctatc aagtatcgct 1085461 tgactataac atttccacac agacaacggc cagctgggct aaggatcagg ttatcagctt 1085521 ttggatcagc tttccaatct ttacgctttg cgttctcgtt ttttattggc tgatcaaaag 1085581 gcatgaaaaa aaatggtggt tatacgcctg gctgttaaca gtgccgtttt cgctgtttct 1085641 gttttttatt cagccggtca ttatcgatcc tttatacaat gatttttatc cgctgaaaaa 1085701 caaagagctt gaaagcaaaa ttttagagct ggcagatgaa gccaatattc cggctgacca 1085761 tgtatatgaa gtgaacatgt cagaaaaaac aaatgcgctg aatgcctatg ttacaggaat 1085821 tggggccaat aaacggattg tattgtggga tacgacgctg aacaaacttg acgattcaga 1085881 aattctgttt attatgggcc acgaaatggg ccattatgtc atgaagcacg tttacatcgg 1085941 tctggctggc tatttgctcg tgtcgctcgc cggattttat gtcattgata agctttacaa 1086001 gcggacggtt cgcctaaccc gcagcatgtt tcatttagaa gggcggcatg atcttgcggc 1086061 acttccgctg ttattgcttt tgttttctgt tttgagcttt gcggttacgc ctttttctaa 1086121 tgctgtctcg cgttatcagg agaataaggc tgaccagtat gggatcgagt tgacagagaa 1086181 cagagaagcc gctgttaaaa cgtttcagga tttggccgtg acggggctga gccaggttga 1086241 tcctccggtg cttgtgaaga ttttcagagg cagccatccg tcgatcatgg aacggattca 1086301 acatgcggag aaagaagaga atgcgccgga acatcaggat gctgacaaat aaaaagaagc 1086361 aggtatggag gaacctgctt ctttttacta ttattgtgca gctgcttgta cgttgattaa 1086421 cccttttcca tagtagaaag agtttccaag atatgttgca gtgctttcta aacgatcacg 1086481 gacttgcgcg tttgtccaag tcgggtgctt agaaagaatt aacgctgctg ctccggcaac 1086541 gtgaggagtc gccatggacg ttccgttata agcgccgtaa gtgcctccag gaagtgtgct 1086601 ttggatggac acgccaggag ccatcacatc aagctcagaa cctgcgctgg agaatgaagc 1086661 tctttggttg ctgctgttta ccgcacctac tgcaatagta gaaggatatt ttgcagggta 1086721 gccgactgtg cttgtgcttc cggatgaacc ttcgtttccg gctgcggcag caacgacgat 1086781 accgctggaa acggctttgt caacgactgt tttcagcgct gtagaaccag taggtccgcc 1086841 aaggctcatg ttgataacat ccatattgtt ggaaatggcc cactcaatgc cgttaataat 1086901 ccagctatat tggccgcttc ctgttgaatc aagcactttt actgcatata atgatgcgct 1086961 tggcgctacg cccagaacac cgattgagtt attaagagcg gcaatcgtac cggctacatg 1087021 cgtaccgtga gaactgccgt cctggtatgg gtttgtttca gaaggtacga agcttgctcc 1087081 gcctctgacg tttaagtcag gatgagaaga gtcaattccg ctgtcgataa cagctacttt 1087141 tacgttagag cctgtgtagc cttgagagtg aagagccggc gctttaattt gagaaatgcc 1087201 ataaggaaca gattgcgcat attcatgtgc aatatgatct tcttccacat atgcaacgct 1087261 cggatctttt ttcaattctt ttacagcttt ttcatccaat gttgctgcgg ccgcgttaac 1087321 atacttaaat tgcttttgaa cctttccgcc tttttcagaa ataacatcct ttttcttggc 1087381 ggaactcatg gcactcattg tctgtttaaa tccgacaatg tatttctttt ctgtactgct 1087441 ttttccggca gcctgcgcag acatgttgct gaacgccatc gtaaagatta acgttaacgc 1087501 aaacaacaag ctgatccaca attttttgct tctcactctt taccctctcc ttttaaaaaa 1087561 attcagagta gacttactta aaagactatt ctgtgaattt attgtaatag atggaataat 1087621 attttagtag acccattttt ttgagatgat tttatctcta tttaggtata tcatctctcg 1087681 ctatttccgt agagactcga aataactatt ttcatacaga aaagaacgaa aatagacatg 1087741 agtaaatgtt cattatgctg aaatgtcatg cttttttagg ttaaatgctc ctgagtcccg 1087801 gcaaattcct gtcgaaaaaa ttcgttcaaa tgacctgcgt gtgcttccgt gagaacaatg 1087861 gatattatcg tgatattttt tcaaagcatg atgataaaag tattctgaaa aataaacttt 1087921 acagaaaagg gatagaatga aaaaattatt gagagggagg aagaaataag atgaacattc 1087981 gccaagcaaa gacatcagat gcggccgcca ttgcgccgct gtttaaccaa tatcgggaat 1088041 tttatagaca ggcatccgat ttgcaagggg cagaggcttt tttgaaagct cgtttggaaa 1088101 atcacgagtc tgttattttg atagcagaag aaaatggaga attcataggc tttacccagc 1088161 tctatccaac gttttcttct gtgtcaatga aaaggatata catattaaat gacttatttg 1088221 tcgttcctca tgcgcgtaca aagggagccg gcggccggct gctttctgcc gcaaaggatt 1088281 atgcagggca aaacggggca aaatgtttaa cacttcagac tgagcaccac aaccggaagg 1088341 caagaagctt gtatgagcaa aacggctatg aagaggatac cggatttgtc cattattgtc 1088401 tcaatgtgcc ggcgaagtga aaatggcggc ttgatgattt ggttttttga acgttcttcg 1088461 gttacgatat aaatgaaaag gagtgtgccg aatgtcaacg ttatttcaag ccttgcaggc 1088521 agaaaaaaat gccgatgatg tttcagtcca tgtgaaaacc atatcaacag aggatttgcc 1088581 gaaggatggt gtcctgatta aagttgctta ttccggcatt aattacaaag atggtctggc 1088641 cggaaaagca ggaggcaata tcgtcagaga gtatccgctt attttaggca ttgatgctgc 1088701 gggtacggtc gtctcttcca atgatccgcg ttttgcggag ggggatgagg tgatcgcgac 1088761 aagctatgag ctcggtgtct cacgtgatgg cggattaagt gaatacgctt cggtgcctgg 1088821 tgactggctg gtgcctttgc cacagaatct ttcgttaaaa gaagcgatgg tgtacggaac 1088881 ggcgggattt actgcggcgt tatcagtgca tcggcttgaa cagaacggtc tgtctccgga 1088941 aaaaggcagc gtgctagtca caggagcaac cggcggtgtc ggcggaattg cggtatcgat 1089001 gctgaacaag cggggttatg atgtggtggc aagtaccgga aaccgggagg cggctgatta 1089061 tttgaaacag cttggtgcaa gcgaagtaat cagcagggaa gatgtctatg acggaacgct 1089121 taaggcgctg tccaagcagc aatggcaggg agcggttgat ccagtcggcg gaaaacagct 1089181 tgcctcgctt ttaagcaaaa ttcaatacgg cggatctgtc gcagtgagcg gcttaaccgg 1089241 cggaggagaa gttccggcaa ccgtgtatcc ttttattctt cgcggagtaa gcctgctcgg 1089301 aatcgattca gtatattgtc cgatggacgt cagagccgct gtttgggagc gcatgtcttc 1089361 tgatctcaag cctgatcagc tgctgaccat cgtggacagg gaagtatcat tggaagaaac 1089421 gccgggtgcg ttaaaagata ttttgcaaaa tcgcattcaa ggaagagtga ttgtgaagct 1089481 ttaacaggat cagcttgcag agaatgttat ttttctgcaa gcttttttgt ggacaggatg 1089541 atcagctgct gaactgctgt gtcgcgaaac aagattttcc tgtaagccga actttctctt 1089601 ctcattttaa aaataattgg tgataatgat tctcattccg tgttatacta ctcttggaca 1089661 tcttaaccat agaaactacc aacaggagag actggaacat atgaaaaaaa cactgattat 1089721 tcttacagtt ttacttcttt ctgtcttaac ggctgcttgc tcgtcttcaa gcggcaatca 1089781 aaacagtaaa gaacataaag tggcggtaac acatgattta gggaagacaa atgtgcctga 1089841 gcatccgaag cgggttgttg ttcttgagct aggttttatt gatacactgc ttgatctcgg 1089901 cattacgcct gtcggggttg ccgatgacaa caaagcgaag cagctgatca acaaggatgt 1089961 gctgaagaaa attgacggct acacatctgt cggcactcgc tcacagccaa gcatggaaaa 1090021 aatcgcttca ttaaaacccg atttaattat tgctgacacg acccggcata agaaggtgta 1090081 cgatcagctg aaaaaaatag cgccgacgat tgcacttaat aatttaaatg ctgattatca 1090141 ggatacaatt gacgcttcgc ttacgattgc aaaagcagtc ggcaaggaga aggaaatgga 1090201 gaaaaagctg acggcgcatg aagaaaagct tagcgagaca aagcagaaaa tcagcgcgaa 1090261 cagccagtcc gtgcttttga tcggaaatac aaatgatacc attatggcca gggatgaaaa 1090321 cttctttaca tcgagacttt taacacaggt cggctaccga tatgcaatca gtacgtcagg 1090381 caatagcgat tcaagcaatg gcggcgactc tgtgaatatg aaaatgacac tggagcagct 1090441 gctgaaaaca gatccggatg tgatcatcct gatgacagga aaaacagatg acctcgacgc 1090501 cgacggtaaa cgcccgatcg aaaagaatgt cctttggaaa aaactgaagg cagtgaaaaa 1090561 cgggcatgta taccacgtgg atcgtgcggt gtggtctctg cgccgcagtg tagacggggc 1090621 gaatgccatt ttggacgagc ttcaaaaaga gatgccggct gctaagaaat aaaagaaaag 1090681 acaggcaaac gcctgtcttt ttcttatttg ataaagccgg ataagtggct gttgatatta 1090741 tagtctttta tccgccattt ttcttctgca aattcaatgt tgctgaggca ggcgttgacg 1090801 agacgggtgc tttgaagctc cgggtcaccg ccggatattt ctgtcagcag ggcgtgaatt 1090861 gccgcaccgt gcgccacgat cagcaccttc ttgtttggat acgcctgatt cacttttgcc 1090921 aaaccgccca tcagcctgtc agtgagttct tctaaggttt ccatattcgg atagatgtta 1090981 tctggatagc gctttgtccg ttcctccagc ggcatgccct ccgcgtcgcc gtaatcgcgt 1091041 tccttaaaat catccatctc gactatcgga agatgcagat attcattaat aatttccgcg 1091101 gttcttttcg ctcttttcag cgggctcgtc acaataatat cccaagaaaa gtcctttaca 1091161 tattctccgg tttctcttgc ttggcgttca cctgttgcgt ttagcgggat atcggttttg 1091221 ccttggcatt tttgctgcag gttccaatcg gtttctccat gtcttactaa acaaacggct 1091281 gtcataaaat ccccttcctg actttattca tatcgctatt atactaaatc gaaagcgtgt 1091341 gtcctatgaa aaagcctatg caagaacttc aaataataaa gccagtccga ttccgccgcc 1091401 gcttccgatg gctgcaacag catattgaca gtctggccgt cttttcgctt cataaaacaa 1091461 tctggttacc agagctgcac ctgatgcacc gtacggatgg ccaagagcta aggcgccgcc 1091521 gcgcacattg atttttgaaa agggaatgcc gagttcttgc gagcagacac aaattttgac 1091581 ggcaaaggct tcattgattt caaataaatc gatatcatca ggtgttacat cgtgtgtatg 1091641 taagagctga cgaatcgcga caaccggtgc cgcgggcgga aagttggggt gaatgccgct 1091701 gacagcgctg ccgataaacc gaagcacagg cttaagtccc agggctgctg ctttttcttc 1091761 ttccattacc aaaagagcgg ctgctccgtc tgctatgcca ctgctgttgg ctgctgtgac 1091821 tgttccggag ctggtgtcga aaaccggctt tgcacgggga ataatcgctt ctattggccg 1091881 cgttttcaaa aatgcttcgt ccgtctccaa ttccccgaga gcaacaactt cttcacggta 1091941 aaatccttca tcatgcgcgt tcctgctgcg ttgatggctg agaagcgcgt actcatcctg 1092001 catgcttctg ctgatggaat agcgtgcagc cgtatattct gccgcaatgc ccatgtctgg 1092061 atcgccgatc gcatctggag aaaagcgagc ccgttctgaa aaaggggatt ggctgctgct 1092121 ttctgagccg cccgcgatat acatcgtgcc ggctcccgct tgaataaggc tgcaggcata 1092181 gcgcacagct tcaaggccgg agccgcactg tctgtcaatt gtcattccgg gaaccgataa 1092241 aggcagtccg gcttgaaggg ctgacagtct ggccaggttg ccgcctctgc cagtagcgtt 1092301 tccgagaatg acctcgtcaa cttgatcctc tagctttcgg ctgagacagc ggatgatggg 1092361 agccgccaaa tcctccggca ggaagggctt cagcagtccg ttttgatttc caaagatcgt 1092421 tcgttttgca tcaacaataa ccgcattcat ttatactgta cactctcttc cagccatttt 1092481 ttcactctgg aacgggcaat ttttccgctg ctcgtttccg gcaagctgtc tgcaaacacc 1092541 cattttttcg gaattttata ggaggctaat ttctgtttac accaggcttt cagtgttctg 1092601 gcattagcgt ttccaagaat gacagctaca gcgatttctc cccaatactc gtcgggaatg 1092661 ccaacgacag ccgcgctttc aacctctggg caggcgagaa gcacacgttc aatttcttct 1092721 gggaaaatat ttaatcctcc gtacacgatc atcccgtttt ctcttcctga tatgtataga 1092781 aagccctctt catcaacgta gcccatatca tctactgtca tccattcatc tggtgtgctg 1092841 ccgttcacat agccggaaaa cctcatcggg cttttgacaa atatttttcc gatttctcct 1092901 ggctggcagc gttctcctcc agcgttgcgg atttcgatcc ggacattatg aaaagggcgg 1092961 cccgctgaat gcggcttccg tttgctgtct tccggtgaag aaaacgtcac aaaactaagc 1093021 tctgatgtgc cgtaaaaatc gtacagcttg agatgaggcc atgcagcggc aagcttcttc 1093081 ttggattctg ccggccagtc tgcgccggat gaaatgattt tgacgggact gtcgggaaaa 1093141 ccctcaatcc ttgcgagggc gtctgtcatc gtcggtacgg tatagagaac actgatggat 1093201 tcacggcaca gccattcctt cgctttggca ggagaaaact ttttcagcaa acaaacggtt 1093261 cctccgagaa acaaagtgct gacagcccca tataggaagt gagaggacat taacgctccg 1093321 ggaatcagaa ccttatcatc tgatgaaatc gaaaaatctg tttctgtaca ggtaaagctc 1093381 tccatccatg agcggtgaga tcgcgtaaag gccttcggtt ttcctgtcga gcccgacgta 1093441 aatcccatat aaaaagggtg ctccggatca atggtaggca agggatcagc ggctgcctca 1093501 gaaatatctg ccatacagtt atccagcaat acaacaggtg tctggctatc tgtcagtttg 1093561 tttttgaaaa aggctaaagt aaccacaaga tccgcattgc ttatggacag ccgctcctta 1093621 cattcagccg ggctccagcg tgtgtcgatg ggaatggccg tacatccagc cgctgcggct 1093681 ccggcaaaca gctgtaaaaa cgcgagacta tttgggagca ggatcgccac acgattcggc 1093741 atgctcggct gtgaccgcag ccaatttgcg gtttgagaga caagccgatc ccaatcatgg 1093801 tacgtgattt gctccgattc agtctggatc gctacacggc cgggcgatgt ttcggcagta 1093861 gatgaatagg tatgagtaat tgtcatgtat tgtcatcctc cttttgtaaa catcgtatca 1093921 gaaagagaca aggcttgagt gatttttatc gccagaaatg cagatacagc cgcttttatc 1093981 aaatcaccag gcacatatgc aaggctcatg aaggcggcct gtgacaaatc aatatgcatg 1094041 ataaaagctt gtaccggtat accaagcaga taaataaaga tgatgccgaa tacgatatga 1094101 gtgaaaaaga gacgcaatac tgtcaccttc cgcagcctgt tagcggctaa actgatcagc 1094161 catgaagcga ggggataagc aatcaaaaag cctgcgctcg gtccgaaaaa cacaccaaaa 1094221 ccgcctcgtc cgccgggcaa cagcggcgct ccgaaggcga cgagcagcaa aaagacaagc 1094281 tggcttaaga aagcagactt tggcctgaga atgctgcctg ccaacatgac accaagcgtt 1094341 tgcaatgtaa tcggaacggg tgtaaaggat aagaagagag ggggcataaa gccgagcact 1094401 gccatcagcg cggtgaaaat cgcaatatgc atcatgtcga ttaatttcag catgtgaaat 1094461 cctccaaaaa gtaatcaaat atggttatac aataaatgca ggtaattatt atgtcaactg 1094521 atttttaatt taagtttaca taatgaacgc aaaaaaaccg gccgtatggc agaccggttt 1094581 ttgatggtta ttcttctgtc aggatgacaa gcgaatcaac ggaagcggcc acatgggaaa 1094641 cggcgcggct gacttcctga agccctccaa gaaaggcttg cagatcgacg tcgattttgc 1094701 ctgattgctc tttgctgatt ttcatgctgt ggacgatttc atcgaataag cggttaattt 1094761 gcgtcatttt ttctttactt tcgctgacta gctcattcac gtctttgata tgcttggata 1094821 caatgttgat ttgtgtattc gtattgttca caagctcaga aacagtagag acggtttttt 1094881 tcgtatcctc agaaagcttc cgcacttcat ttgccacgac agcaaagcct ttgccgtgtt 1094941 ctccggcgcg ggcggattca atagatgcat tgagcgagag aaggtttgtt tgttcagcta 1095001 tgcctgtgac gatgccgaag attttttcaa tttgctgcgc gatttcatcc agcttgacca 1095061 tttctttttc gatttggaca aggcttgtgt caattttgtt catctgtttt tgctggactt 1095121 ctagctcttt ttttccgccg atcgactttt cttcaacagt gctggatgtt acagtgccgg 1095181 ctttggatgc ttgagaaatg ccttcagatt tgtccacaag ctcttgaact gatctgcttg 1095241 tttctgaaaa cagattggca atcgatccag aggtttcttg aattttctga tgaagaaggt 1095301 ttttcttttc ttcttgttca tcacgggtct ggttgtactc gctttgaaac gcttcaagga 1095361 caagctgctg ttctaagttc aagatttttg ttgttgcttt aatggctttt agcagttctt 1095421 gctgatttgt aatggacgct tcataaatgt caatcattga caaaaggagc tcttgaaacg 1095481 cacccatata ccattttggc aaaaggccga ttcttaaatg gatggaggcg attcggttac 1095541 gcttttcaat aaattcatca tcgataacgc ctgcaaacat ttcctgaata tgccgtttta 1095601 acgtttgttt taagcggtca actgagctgt gatcattaat gatatccatc aatgagcttt 1095661 catggtcaag gtttttataa aacgcatcga cgatatttac gatattttct tgaatgagtg 1095721 gctgaagctg ctctaacaca taaagctcag catctcccaa cctgaccatt ttgagctgtt 1095781 ttttgacatc tgcatgtttg tttgtgagct gaatgcggtt tttttgttgt ccgtttgaat 1095841 ctgaaaagta agctgtttct tgttttctgt cttttttaaa taacaataca atgatccccc 1095901 ttgggaaaaa tataattttt actttttggc tttttaagcc tttttctttt ttatcggcca 1095961 agggaaacat gaatgaagct gcagatgaaa aatatttgaa aaaacgttca ttaaaatgaa 1096021 cggtttaatc gagatctatt tgttttaatg gtttaatggc cggaccctct acaacttcgc 1096081 cagatggctt aaagcgtgat ccgtggcacg gacaatccca cgtatgctca ctgtcgttcc 1096141 actcgacctc gcagcctaaa tgggtacaag tcgtatcaac gagatggagg cagcctgtct 1096201 catcacgaaa tgctcccgct cgcctgccgt ttatggtgac ggctttccct tctcctggcg 1096261 aaatgtcttc aaattggaca tcaggctttt caagctttcc ttttatcaaa tgcttggcga 1096321 catctgcatt gtaggaaatc actttctgca acccgggatt cagatggaaa cgggacggcg 1096381 tgaaaatgct ttcgtatggg ttttcttttt tctccacaag gtctgacaat aaagtggctg 1096441 cgactgctga ggacgtcatg ccccattttt tgaacccggt cgctactaga atattgtcct 1096501 cattttccga catcggcccg ataaacggga ttttgtcgat cgtcactaga tcttgggtgg 1096561 accaataata tggaatgctt tcgatgccga tggtgctttc ggccagttgt ctcagtgttt 1096621 cataatgtgt agacatggct tttccctggc ctgttttatg gcttactccg ctgaagagaa 1096681 tcagcttttc accgtttaca accgtatagc ggagcgccac tgacggctga tcgatactca 1096741 aatacatgcc ctcgggatac tcgatcttcg gcttgatggc aaggacataa gatctgtcgg 1096801 agtacattct cgcagcatat aatccgcctc cgtcataaaa agggaagtgg gaacagcata 1096861 tgataaagcg gctcttaatg gcgtgccggc tttttgttac cacttcgggc ctttcgcctt 1096921 ttttgatatc aagcgcaacg gtctcttcat aaattcggcc gcctttttga acaatttgct 1096981 ccagaagcgc ttttaagtat tgaagcggat gaaattgagc ttgattcttc atgacaagcg 1097041 ccagcttaga acctaaggga attggaagat ccttgataag gtctctttca attccgagct 1097101 ttgtgtatgc ctcatgctcg gtgtggattt tttgaacagc gttttcattt gccgtataaa 1097161 gatatgcgtc ttgctcgatc cattcacaat caatttgatg ttcatccaca atgcctttta 1097221 tgtaatcaat tgcgttttgg tttgcttcat aataaagcct cgcatggttt aatccgaaat 1097281 ggcggataaa ttcgtcgtat atcatgtcat gctgtgcggt aactttagca gttgtatgcg 1097341 cagtggttcc gttaagaacc tgatttgctt caatcaaaac gacacggaag cctctcttcg 1097401 taagttcata tgccgttgtg attcccgtaa tcccgcctcc gataatggtg acgtcacatt 1097461 cagtgtcctc ttgaagcgca ggaaaagaag gcaggtcagt tgatgttttc cagtatgttt 1097521 caggtgcttc ctttgcaaaa tgttgattag ccaagccgtt atacctccaa tcagatttat 1097581 tcttaatttt tccatattct atcttttcat acataggaag caggcattgt tcataacata 1097641 ataaggttga aaaggagtga tttcattggc gaatcaaaaa aagaaaacat taccgcctca 1097701 gcaccagaac cagcagcctg gttttgaata tctgatggac ccgcgtccgg tttttgataa 1097761 gccgaagaaa gcgaaaaaat tagagggcaa aaccgctatt attactggag gagacagcgg 1097821 gattggacgc gctgtctcgg tgttattcgc aaaagaaggg gctaatgtgg tcattgtgta 1097881 tttgaatgaa catcaggacg ccgaggaaac aaagcagtat gtagaaaagg aaggggtaaa 1097941 atgcctgctg attgcaggag atgtcgggga tgaagcgttt tgcaatgatg tggtcgggca 1098001 ggcaagccaa gtgtttccat ccattgatat attggttaac aatgcagctg agcagcatgt 1098061 ccagcccagc attgaaaaaa tcaccagcca ccagctgatc agaaccttcc aaacaaacat 1098121 tttttccatg ttttacttaa caaaggcagt gctgcctcat ttaaaaaaag ggagctctat 1098181 tattaatacc gcttcaatta ccgcctataa aggcaataaa acgctgatcg attattcagc 1098241 gacaaaaggc gcgatcgtta cgtttacaag gtccctttcc cagtcgcttg ttcagcaggg 1098301 catacgggtc aatgcagtgg caccgggtcc catttggaca ccgcttatcc cggccagctt 1098361 tgccgcaaaa gacgtggaag tgtttggttc agacgtgccg atggaacgcc cggggcagcc 1098421 ggtcgaagtg gcgccaagct atctatacct tgccagcgac gattccacat acgtcacagg 1098481 gcagacgatt cacgtcaatg gcggaacaat tgtgaacgga taataaaaag ccaatccttg 1098541 aaggattggc ttattcgctc tgcttgagcg ctgcatattc tttagagagc gtaagaaacg 1098601 catctttatc tttttcgtcc aaggctttgt taatttggtc cgtcagcatg gcaagccgac 1098661 ggttatacaa ggattcatcg agcaccattt gaatgtaaat atccgtcatt gtgacatcga 1098721 attcttttgt tttttgcgtg ttgcgggact tcatgagctc agtgtacgat tttttctctt 1098781 tcataaagaa tccccccaat gcctttttta tagtatatgg ataacggtcg aaaaaatcaa 1098841 taaattttta taatttttag acaactaata cttggcaatc tatcgacata tcctgcaaaa 1098901 tgccgtaaac cggcaagtct tatgaaagta aaatcggttt attactagtc atttagtacc 1098961 attaaatatc attaaaagat gattttatct taaatgttaa aaaaacctgt cgttttacaa 1099021 aaacagatga tagattatta gtataaattt tgcagaaaaa ggatggaggc cataatatga 1099081 gtcagaaaac agacgcacct ttagaatcgt atgaagtgaa cggcgcaaca attgccgtgc 1099141 tgccagaaga aatagacggc aaaatctgtt ccaaaattat tgaaaaagat tgcgtgtttt 1099201 atgtaaacat gaagccgctg caaattgtcg acagaagctg ccgatttttt ggatcaagct 1099261 atgcgggaag aaaagcagga acttatgaag tgacaaaaat ttcacacaag ccgccgatca 1099321 tggtggaccc ttcgaaccaa atctttttat tccctacact ttcttcgaca agaccccaat 1099381 gcggctggat ttcccatgtg catgtaaaag aattcaaagc gactgaattc gacgatacgg 1099441 aagtgacgtt ttccaatggg aaaacgatgg agctgccgat ctcttataat tcgttcgaga 1099501 accaggtata ccgaacagcg tggctcagaa ccaaattcca agacagaatc gaccaccgcg 1099561 tgccgaaaag acaggaattt atgctgtacc cgaaagaaga gcggacgaag atgatttatg 1099621 attttatttt gcgtgagctc ggggaacggt attagaaaaa taggaaggag ctgaccgaac 1099681 agggcagctc ctttcataaa gctatgccgt cggaattcct ccggtgatgc catatacctg 1099741 agatgtcaca tagcttgaat tctctgaagc tagaaataca taaacatcgg ccaattccac 1099801 tggctgccca gcgcgattta atggagctgg cggcgtgcct tgtccgaatt tcgggatgtt 1099861 ttccgtcggc tgtccgccgg aaatttgcag cggtgtccaa attggtccgg gcgcaactga 1099921 atttactctg atgcctttgg aagcaagctg ttttcccagt ccgacggtaa agccgataat 1099981 ggcgtttttc gttgctgcgt aatctaacag catcgggctt ggattatagc cttcaactga 1100041 ggtagttgtg ataattgaag ctccctccgg caaatacgga agcgccgctt ttacaaccca 1100101 gtaaagggaa aagacgttca cttcaaatgt tttatagatt tgttcagtag gcagatcttc 1100161 gatgttttcg accgcttgct gtttgcctgc aacgagcgct agcacatcaa gtccgccgag 1100221 ttcgtgatgc gactgtttga ctagatcttg gcaaaaggat tcgtcgctca agtctccggg 1100281 gatcagcact gcttttcggc cttctgcttc aatcagctct tttacctctt cagcatctgg 1100341 ctgttcctcg ggcaagtagt taatagccac atcggcacct tctctggcgt aagcaattgc 1100401 ggcagcgcgg ccgataccgg aatcgccgcc cgtgacaagc gcttttcgac ccgttagttt 1100461 acctgatcct ttgtagcttt tttctccgca atcagggaca ggcttcatgt tcttttgcag 1100521 gcctggcggt tcttgatatt gttcgggaaa ttcatcatga aaaaatgctt ttataggatt 1100581 cgtaagattt gaatcagaca tcagcaacgc tccttttctg tttggtgtac attcgtatgt 1100641 gtacccctga gcataagcag aaaaacatgt tttggcagtt tgaatagtga aggaaaaaga 1100701 aaacaagaaa aaacaaagcc ttcttccata tttatcttgt caaataagac tatatgaatt 1100761 atgataaatt cgagctataa atcaactaaa tattgggtgt tgggagagtg aatcgtcatg 1100821 aaaaaagcgg cggcggtttt gctgtcactc ggtctcgttt tcggtttttc atacggagct 1100881 ggccatgtgg cggaagccaa aacaaaggtg aaggtctata agaactgcaa ggagctaaac 1100941 aaagtataca aaggcggagt ggcccgcaca tcgaaggtga aaaacaaagg cggaaaaacg 1101001 aagtacaagc cttacgtttc taaggcactt tacgatgcca ataaaaacaa agaccgcgat 1101061 aaagatctta tcgcctgtga acggtaaata agaaaaagca atctggtgtc cagattgctt 1101121 tttttatgct taggccgcct gatcggccgc agcgcttttc gccttccttg tcataaggct 1101181 gactgccatc atgaccgtga tattcaaaag cagggcgacg atgccgacat tcaagtcttt 1101241 tgcggcttgc ggcagagccg gaaataaagt gccgatcgtc gtttccgtca ttgtaatata 1101301 agtaactgct ccgacacctg caataatgcc ggcgaaagct ccttgctttg tcaccatatt 1101361 atgcttgagc aggctgaaca aaagggcggg gaatagctgt gtgacaaggc tgtagcccat 1101421 caaaagcagc gtaacgatgg tattcccgcc tttgaaggta aaatacaccg aaatcagcgc 1101481 aatcaccggc actaaaaact tagcaagcgc cgatacttgc tgttctgtcg tgcggggcgc 1101541 gattaccttg tacacatttt ttgcaaacag tgtggaggcg gacattaaga tcatagaccc 1101601 tggcacaagt gctgtcagca gtccggcagc accgataatt ccgacaaacc aagggtcaaa 1101661 tgcttgcaga gacagtctca aaagcgacaa atccccgtct gcgccattca gatctggaac 1101721 ttgcaggata gccgcaaagc cgacgaaaag gacgaagagc aggaccagct ggtacaaagg 1101781 catgatgatg gcgtttttac gaaacacttt tgggttttcg gctgaatacg aagcggaaaa 1101841 cgtgtgaggc cacatgtaaa aaccaagcgc tgtcaagagt acggttgaac tgaaccaggc 1101901 cacactttgt cccgattcgg ggagcgtaag aaagccaggc tttgccgttt caatctgctg 1101961 aaacatgtct tgaaatccgc cgtagtaatg aattggcaaa tacacaccta aaaacagaac 1102021 gacaaccaga atcatgatgt ccttcacaac cgatatccag gcagacccgt gaatgcctga 1102081 aaccataaca taaaccgtga tggaaacagc gccgatccag atggcagcgg tcggggtgat 1102141 tttgccgtac gaggtttccg atacaatcag cccgaggcct ttcagctgca gtacaagata 1102201 gggaatgagt gcggcgatgc cgaccagtga aacgagaatg ccaagcagcg gactgttgta 1102261 tttttttgtg aaaaaatcag actgcgacat cagtttatgc tgtttcgcgt acgtccaaac 1102321 tgctggaaga agccagtaag aaaggatgta ggccagacat ccgtaggcga tgatataaaa 1102381 ggctggaccg ccttttccgt aggcccagcc gctgccgccg agaaacgtaa aagtagtata 1102441 aatttcgcct gccatcaaaa ggaagacgaa aacagttccg aagccgcgcc ctccgaccgt 1102501 ccactgctcc aggttcatgt cttttccttt ttgggcgcgt ataccgagaa aaatactcaa 1102561 gagcaggaca ccgaagatga tgatgagagc tgcattcatt ctgcttcctc ctttttattt 1102621 tccttgtcga ggacatacac aatcgccatc agcgcagagg tcaaaagagc ccacatcaca 1102681 atataggcaa gaataaacgg catgccgaac acataggggg tcaccttatt tgcaaaaggg 1102741 atgccgagta agattccgat aaagggtaaa gcggcaagaa cgtgaatcag tttcatagaa 1102801 tcctccttct atttaggatt gaggtgtaca agcctaagcg tactgaaaat gatgtcgcag 1102861 atatcgcagc acatgtcatt ttttggagtg aaaggctgtg gttcgaatta taaataaatt 1102921 tattttgttt gtatagtgtg aattgtctga aattaatgct ctgaatcgcc cgaagaggga 1102981 acgggcagta tgattcaaaa ggctcagagt ctgtctgggg caaatagata gtatgttaat 1103041 aattcgctga cctgctcacg gattcgcgga ttaaaatagc gatggttttc ttcataaccg 1103101 tcgatgacaa atgtatagag tgtaaaggcc tcatcgcgtt ccgtctcgcg gattgcaatt 1103161 tttcttttcc tcagttcttt tctgacctcc atcaaatcct tttgtgctat ttttaatgat 1103221 tcgctgataa gctgtttata aggatgcttc aattttaatg tgctttcttc aattccggcg 1103281 agatcacggt taaaaatcgt aatggccatg ggcaaaaaga gagcccgttc aattaaatcg 1103341 tatatttcct cctgcagatt tggcatattg actccttctt tctaagggaa cgtttgttct 1103401 atttgtattc tatatcggct ggtgaaatgt ttcaagacag aaaaaatcac caaaactttt 1103461 tagttttctg ctgataatgt gtagaataag gatagacaaa cccggtaagg agtataaatg 1103521 ttggagcatt ttttatccta tttgacacaa gaacatttaa ctgaattatt tcaaagctat 1103581 agggctttcg gtccgctcat tgctgtgctg ctgcctttaa ttgaagcatt tctcccgttt 1103641 ttgccgctga tcgtgtttgt ggtggcgaat acgaactcgt ttggcttgtg ggaaggattc 1103701 atcctatcct gggcgggatc aactgctggt tccattctcg tctttttgat tgtccgtcaa 1103761 tacggacaga gaaaattgct tggatttatc cgcagtcatc cgtctgtcag aaagctgatg 1103821 ttatgggtgg aaagacacgg cttcggtccc atgtttcttc tgctttgttt tccatttaca 1103881 ccgtcagccg cggtgaatgt tgttgccggt ttgtcaagga tcggaacgcg gccgtttatt 1103941 ttggcggcag cctcggggaa gcttgtcatg atttttatga tcagcttcat cggatatgat 1104001 ctgcacgcgc tgattacaca gccgattcga acggtcatcg ccgtattggt gatcactgtc 1104061 ttatggtatg tcggcaaaaa ggtggagcgg tatctgcatg taagagccag tcagcgtgag 1104121 catgatggag ggagacagta acatgaaaaa acggttttgg tttcttgccg gtgtagtgtc 1104181 cgttgttctc gccattcagg ttaaaaatgc tgtctttatt gattacaagg tagaaggcgt 1104241 cagtatgaac ccgaccttcc aggaaggaaa cgaattgttg gtcaataaat tttcgcatcg 1104301 atttaaaacc atccatcgtt ttgacatcgt cctttttaaa ggccctgatc ataaagtgct 1104361 gattaaacgg gtaatcggct tgcccggtga aacgatcaaa tataaagatg atcagctgta 1104421 tgtgaacgga aagcaggttg ctgagccatt tttgaagcat ttgaaatctg tttctgccgg 1104481 cagccatgta acgggtgatt tttctttgaa agatgtgacg ggaacaagca aggtgccgaa 1104541 aggaaaatat tttgtcgttg gagataatcg catatacagc ttcgacagcc ggcattttgg 1104601 tccgataaga gaaaaaaata ttgtcggtgt gatttctgat gccgaataaa aagacgctaa 1104661 ttgaagaggc gtctttttgt atgccgtttg gaaaaatgtg ttgaagaaaa atttgtaagg 1104721 agctataatc aaaattgtta cctgtgtaac aaaatttata tatttttttg actggagggc 1104781 cgtttttatt ggtttttgtt cgtttttcat gaaacaaaag gagtggtgaa tgatgatgaa 1104841 atatgaagca gtgattatag gaggagggcc ggttggattt atgctggctt ctgagcttgc 1104901 aatagccgga gtgggaacat gtgtgattga acggcttgaa aaacctgttc cgcattccaa 1104961 ggcgttgacg ctgcaccccc gaacgctgga gcttcttgag atgagaggga ttttagagcg 1105021 gttcgtatcc aagggaagca agatacctac cggacatttt tcaatgctgg atacccgtct 1105081 ggatttttca ggcttggata cgagctgtcc ttacacgctt ttgctcccgc agtccaaaac 1105141 agaaaagctt cttgaagatc atgcacgaag cctgggaaca gaggtgtttc ggggtgccga 1105201 ggcgctggcg gttacgcaaa acggggaagc ggtccaaaca atttttaagg atcgggacgg 1105261 cagtgtacgg acgatcacaa gcaagtttgc cgttggggca gatggcgccg ggagtaccgt 1105321 ccggaaacag gcgaaaattg agtttccggg aacagacagc actgtcaccg ctgcgcttgg 1105381 ggatgtggtg ctcctttctc cgccgccgtc aggtgtgctg tccctttgca caaaagaggg 1105441 cggtgttatg attgttccgt tatctccaga ccgataccgt gtcgttgtga tcagccctta 1105501 tcgcacacaa acgccgaaag atgtgcctgt gactgaggaa gagctgaaag ctgacctcct 1105561 gcgaatttgc ggaactgact tcggtttaac cgacccttcg tggatgtcgc ggtttgggaa 1105621 cgccgcgcgc caagcgaaac ggtatcggga cggcagaatc tttcttgcgg gtgatgccgc 1105681 gcatattcat tttccggcgg gcgggcaagg actgaatgtc ggccttcagg atgcaatgaa 1105741 cctcgggtgg aaactggcgg cggccatcaa aggctctgcg ccttcttggc ttttggacag 1105801 ctaccatgat gagcggcatc cggcagcgga agggctcctc agaaacacgg aggcacagac 1105861 aaagctgatc gatttcactc aagcaggcct ccatttgcga agcatgatgt cggagctgct 1105921 ggccttccct gatgtgaatc gatatgtagc ggggcaaatt tctgcgctcg atgtcagata 1105981 tgaagctgat cgtaccatgc cgccgaatcg tttgaacggg gcaaggctcc ctgacatgaa 1106041 gctgattctt tccgacggca attcggaacg gctgtacagc tttctccaaa acgggacatt 1106101 cgttttgctg tcattgaggc aggaagctga tgatcatatc gaagtaaaag gcttacgtac 1106161 ggtaaccgcc tcgcttgcag aaccgaatga aaagttgcgg aatgtgcata ccatattgat 1106221 tcgtcccgat ggacatgtag cctgggcggt ggatgcatca gcgcccgatt gttccgaggt 1106281 gattcaaaaa gggatcagcc gctggttttc cgtcaccagc cgagtataat tcaattcgat 1106341 tgtttcatct gtaacaaaac ggtatgatag aagaaacaat cgaatgaaaa aggatggaaa 1106401 acccgatgaa cacagatcat acgaaacgca atctttttga attgtatgcg gagctcattc 1106461 atcagcagga gaaatgggag gggcttatta aagccttttt atctgacgaa ttgaggaagc 1106521 tggatgtaga gcacgggagt aaatctcaat tgacgatgac agaaattcat gttctatcct 1106581 gtgtcgggga caatgaacca attaatgtca cgtcgatagc agaaaaaatg aatacgacaa 1106641 aagcgactgt atcacgcatc agcacaaaat tgctcggcgc aggcttcctt cacagaacac 1106701 agctcagcga taataaaaag gaggtctact tccgattgac gcctgctgga aaaaagctgc 1106761 acagtttgca caaatattat catcagaagg ctgaacagcg ttttctgtca ttttttgacc 1106821 gctataccga ggaagagatt ctttttgcgg aacggctgtt tcgggatctg gtgacaaaat 1106881 ggtatccgtc gtcagaagaa attgaagggg ggcttcctag catttttaaa taaaaaacac 1106941 gcactgcggt gcgtgttttt cgctttgttt ctatcttttt caaggctgta acgtaaatca 1107001 gatttcctct tgaagaatga aattcaagat gttcaggaat ttgcactgct tatacgatat 1107061 gtctattagt atctttattt tatacgtttt ctactgtgtt tttgatgctt tgttttcaag 1107121 tgaaataggg tcttctgttt tagttctcct aatctttaca gaaataccta ctagaatgac 1107181 cgccatagtt gtaaatattc ccatggttaa taagatcgta tcctggttta aactccatcc 1107241 aattaagaaa gagatgatcg ctcctccgaa acttgccgag gcaataaata aacttgtaac 1107301 ttcgtcaacg tacttctgaa taatgattga tgctagtgtt aaagcaatgg gaaatatccc 1107361 cgctatactt aggccaatca aaaatgtacc actcaattga agtattgggt tacttatata 1107421 agagaaggca atcaacaaaa caattaaaca actacagcta aaaagaaggt atttggaaaa 1107481 atcaagcctt ctacttacga aaccaatcaa tattcttcct atgatgatcc ctacccagaa 1107541 aaaggagaca cttataagac taatttgttc attgtcttgg tttatcatga ttgaaggtaa 1107601 aaagttggca aaatttgttt caattccagc atataggaaa gcgaaaaata caaaaaagcc 1107661 taattgcttt gatttttttc tatctcctat aaagtattga aatgctcctc catctggaaa 1107721 ggtcacttgt tggttagcat tcttagcgta ctctcggttc ttagacaaga aaattaacca 1107781 ccctacgaat aggacgaata aaaaggtgaa tatacagtaa tatggtaaaa accagttatt 1107841 gatatctatg aaggaattaa ttaataatgg gaaagataaa gcgcctaatc caaagagaac 1107901 ttccagctta ctcatttttt ctgcattact ttcgaaatta gcaataacaa atgaaccaac 1107961 tgtcgtttct aatgtgcctg ctccatatcc taagagaaaa gccattacaa taatataata 1108021 ccaatccttg gttagaaaaa agatacttaa cgctacaagc attattgtca aagctaaagt 1108081 aagtgtccta aaatgactgt atttcttaat cattaaaggt gcgattaata ctccgcttag 1108141 aaatccggta aactggaaga agattatgac cgaaatatca tctgttgtct tgttaaaagc 1108201 ctctaataaa aatggtgtca aactccctgt tgatatatgg ataataccta ctgtaaaaaa 1108261 gaaagcatat ccaaataaat atgtccctct taacattcat tacaccccta tatgaaaaag 1108321 caggaaagta aattcctgct tttttagtaa cttctctctt tgaaatacta gttgactgct 1108381 gaaacagaca tgggttgaga gttgctgtct ttctcaaaga acatttctaa tacttcctga 1108441 gatctaaaac catcactaaa agaagggatc tcaacccaat cattctgagt tgatgcaatc 1108501 caattgatta actcgcttct aaaagaatca gcccatccat aaaactcgtt tggcggatcg 1108561 tttaataggc tttgcggtac tgggcagtct accacgttca agccatctat gagcttgtaa 1108621 acgtgaggat tacctgtgtg gtatttaaac tcttttttgt gtccaactac ctcaatgcta 1108681 aaaccacagt cttcaggtac agaacacttt gatgtgatga tatttacaaa taccttgttc 1108741 ttcagctggc cataaatttc tgcatagtca tctacaagta cctgtttatc ctcttttgtt 1108801 tttacatttg tgttcatctt tgcccttact gattctgtga tgaaatcact ctcgaacaaa 1108861 taccatacca tgtcaataag gtgaataccc agatccccca atgatccact cgtcttctta 1108921 ctattagcgt catctctcca agtaaacttc ttacgtctaa gtgcactatt tttcttgaag 1108981 tgtactttta tggacagtat gttacctagt tcattattga taattaagct ttttaagata 1109041 tttacgtaag ataaatatct ataattaaat cccatactgg ctcttacgct caacctttca 1109101 gcagtatctt tcattatgct tgcttcttca agagaaatag ccataggctt ttcacataat 1109161 acatgcttat gttttcctaa tgcttgcaaa gcatgttctt tatggcaaaa gtttggtgat 1109221 gctacaatta aaccttctga ggcatcaatt agttcatcta cgttttcaaa tgacttcccg 1109281 ccgaaagttt tcacaaagct ttccgcattt tgttgattta tgtcatatac ccctactaac 1109341 tctgcatttt ttattgtaga taaagcagtt gcatgcgctc ttgcaatacc acctgcacct 1109401 atgatgccta tcttcttcat ttttatttcc tcctcatgat ccaattaatt tttttaaggt 1109461 attagtaatt ccttttgagt actcactatc agttataagg ttgtgcaagt ttttggcttc 1109521 ctgtgttgca ttttttagca gatatccatt ccctactgtc tgtaacatac gaacatcatt 1109581 tccactatcc ccaaatgcga tagctctttc ggtatttagg ttgtatttct ctaacataaa 1109641 cgttacaatt tcattctttc ctgtccctat ggggataaaa tctacatcat agctgtcttc 1109701 tggatcgcct gctaagggat tacaccgatt tatatttact gaaacgccgt attcttcgca 1109761 gattttttca atagctaata ggtttttctt gtcgtttatt tcatcttgtt cctgatagta 1109821 gaagttatgc ttataccgtg actttcctaa ttgggtttga ggattcaaaa gaatgttatg 1109881 attttcatgc agctgtttca caagtttttc aaccttttct ttactaaacc cttcatttat 1109941 gcgactgttc cacttgttat cttgctgacc gaagttatgc tctgaaaagt acgtaatttc 1110001 agttccaaga tcactagcta taaaatgcgg aaaatatcta aattttcctc gtcccatttt 1110061 atcgagaata gattctatac tgctcccagt aacccatccg attattagct ccccatcttt 1110121 acttttttgt tctagatagt cttcgagttc atagatgtct tgttgctttt gttcgtcgat 1110181 tgtatgcgga aaatacgttt catcaaaatc acaaaaaaca atatattgag gatgttcaac 1110241 cgtggataac gttttatact ccgatttctt gcttaataac atgaaacagt ccctccatta 1110301 ctctgtcttg ttcttctaaa gtaaatgacg gatataaagg caaatgcagt acctgactat 1110361 gagccttttc cgtatgaacc aattggagtc ctgcatactt gtcctgtact aaaggagttt 1110421 tttgcatatg agaaagtatt ggataatata catctgtttg aacaccaaaa tcttcattta 1110481 atttagtcat gatatctgcc ctatcttctg ttcttacctt aataggaaac agatgccata 1110541 catgatcttc acttaattct ggtaattcaa tatagccttt attctgcaac tctgctaatt 1110601 gggtaatgta tctatccgcc aagaacaatc ttttgaagtt gtttaatgaa aggtacttca 1110661 ttctctctaa accaattgct gcctgtaaat tgtccatttt tgaattaaat ccaaaattga 1110721 tgactttctt attttttaca tttacttcaa aaccgtgata actaaattga atgcattttt 1110781 tagcgagttc ttcattatca gttgctattg ccccagcctt gccacataca ccaaaattct 1110841 tatagggatt aaaacttaat gtagtgatgt ctgcatactt tcctaagtct gtcagtccaa 1110901 ttccttggca ggcatcttca attactttta atttataacg atttgcgatt tgacggatat 1110961 gctgcatgtc tgaatgtttt ccgtataaat gcacaggtag aataaacttt gtataaggag 1111021 ttattgcttc ttcaattttg tcaggatcga tgcagaatgt ttgtgggtta atatctacat 1111081 agataggaac gcctcccgaa gctaacacag cattttcagt agctgaaaag ctattagccg 1111141 gcatgataac ttcatcccct gggtttaacc ctaaagccaa taaacctatc ataatagcat 1111201 cggttccact gctggttgca attacatacc ttttatgtaa atatgtagat aaaacttttt 1111261 cgaattgctc taaataggga ccactcgtaa attttccagt tggcaaaact tcagttaatg 1111321 tatttaagat atcttccact tcatcattgg ttattaatct gtctacaggc aaaaaaggga 1111381 ctttactgat ttcacgattt ttttgatagt tgaaaaggtc atgttcaata tctatctttt 1111441 cttttaatac ttgtttccac cgctcgttta caatactgtc ttcaataaca agttcttttc 1111501 cttgtacgtc accttttaag tgttttaata gtgacatgtt ttctttgctt ttacctgaaa 1111561 tcttaacctg tttttgcatg aacagtacct ccaatgattt tataatctaa aaatttatta 1111621 caaatttatc ctagtttctg aaatcggtaa catgtcaaca acttttttaa ggaagggaaa 1111681 atatgcctac aattgatgaa atagcaaaat tatgcaatgt gtctaaaacc acagtgtcaa 1111741 gagtattgaa taatcatcct tatgtgtcga aagaaaaaag agatatgatc ttaaaggcta 1111801 ttaacgaact tgactacact cccaattatt tagctcggaa ttttaggaga aataagacac 1111861 aaacgatagc tttatcggtt ccgagtatcg accatccatt ttttgctcaa ttaataaaag 1111921 gggtctctca tgaagtactg tttaagaatt acaaggtaat tgtatttcag accttttatg 1111981 acaaacagac ggagctagaa ttactagagt tattgaagca taaagaagtg gatggcatta 1112041 ttcttgggac tttagaaaat gaatgggatc agatatcccc tttcttaaag tatggtccta 1112101 tcttattatg taatgaatat catcactcag cggacatcac gataattggg tatgatgaat 1112161 ttgaagccgc atacatgggg gtagtacatt taattgaaag agggcataaa aaaattgggt 1112221 tttgttttga tactccatat agcgaagctc aatgtcagag gaaagagggt tatttgaaag 1112281 ctttacaaga ttacaattta catcatagaa gcgaatggat attcggcgaa atgtttaata 1112341 tcgaggatgg ctttcgtgtt tttcataaga taaaggatct aaaggacaga ccctcagcaa 1112401 tatttacagg aaatgatcaa gtcgccgcag ggattattaa acaggcgatg aaaaatggct 1112461 ttaaagttcc agaagactta gctgtaattg gttttgacaa ccaattgatt tgccaagtcg 1112521 ttactccgac cataacaaca attgatatcc ccgtaataga attaggccaa caggctgtgt 1112581 tgaaaatcat cgagtccatt tcgggtaatg cctctttaaa cagaagaatt attaaactgc 1112641 caacaaagct tattataaga gaatcaacgt aacgatagat ttccctttaa cattttatat 1112701 ctttatataa gaaaaagagg ttattcattt taacctcttt ttcaatcgta agtcgtcaat 1112761 tatttctttc atttcaccct ctggcagcac tcacttcaaa tctgatccat taacaacgaa 1112821 atatccgctt atatttcctc atctcgatgg tttgcgaatt aaaagttctt gaaccctttt 1112881 ttcaactagg cactactgcc gctgattgag ctctttttgt cttttttttc accatgaaga 1112941 tggtgaagca ggcgataaaa cggcggcagc agggcaataa ccagaatgac gcgaatgacc 1113001 tgaaccgcaa cgacaaaggt ggaatcagca tgtaaggtaa ctgacgtcgt cgccatctct 1113061 gcaatcccgc cgggcgcaaa tgccagaaca gaagtgatga gcgaaattcc tgtcagctcg 1113121 gaaacgatca cggcgctcaa aaacattgct gcgattaaac cgacggacga gacaaacccg 1113181 acgatgataa tacgggtgac gccggcaaac atgcttttgt acatcttaga gccgatcgtt 1113241 gccccgagaa atacttgtga tacatggtta gcttgtgaca accaccatgc cgtcatgtcg 1113301 tgccctgtca ccgcagctcc gccaacatgt acaattgcta caccgagcat gctgccgagc 1113361 agccatggag ctggaaattt taaaaatttc gcagctttgc aagctcccca ggcagcgaga 1113421 ataagaatga cggtccacaa aacgggagcg agcctaaaat ctgtcgttgc agaagaaatc 1113481 gtctctgctg cggcacttgc ggtacgatct tgttttgtat agatcagaat gactaaaaac 1113541 ggaatggaaa gcaccacgag cagcacacgc atcatttgaa cgaggctgac tatagcggta 1113601 ttggcgccta cttcctgtgc gatgctcggc atggcggaaa gtccgccggg agcggtgccg 1113661 acaaagctag tcatcatatc cgttttgctg aaacgccaaa gcacatatcc tgacagcatg 1113721 gccagcagga tagacaatat cagcataacg ccgactgaaa accaatggtc tttgagaaca 1113781 gagagaacgg ataaattcag cttttggccc aattcgatgc cgaggatcat ctgcccgagg 1113841 gcgagccatc gtcggttaat tcctttttgg tctggtgcca tcatcagcca tgccggccgt 1113901 atcatggcga ggcagcaggc gacaatcagt gttccgatca tccatccaat tgatattccg 1113961 gttaatgaaa gaataaaccc cccggctgca ctgattgcga taaaccatag atctttgagg 1114021 agattttcgt ctttcttcaa tgtaaaaccc ttcttccttt ttcacgtaac actccaattg 1114081 ttcacgtagt gaatgtattt attactatag tatatttttg ttgataaaga aattatgaat 1114141 tattttctat aagcgattca cttttcttat gaccttgtgt tcgagctttt ctattgtgta 1114201 agtcagagat aaacccgctg tcagcagaca cacggcaaga gcgtaaaaaa tcacttctcc 1114261 gccaaatgat gtcaggatca gcccgcctgc cagcggtccg attgagcggg atatatccca 1114321 atgcagacca tagacagcat aaaaccggcc cagcaaatga ggcggcgcca atttcgatat 1114381 gaaggtctgg atgtgggtta gcccgatgct ttcaccaacc gtcatcaccg ctgccgtcac 1114441 taaaagcatt gtcagagagg ttgagcatgc aaagccggct gccgcaaggg agtagcaaat 1114501 ataagtaatg aagaggatcg ttttcattga aagcttttcg gtccctttga caagaggtac 1114561 ttggagaaca cagctgaata aagcttttgc tgctgaatag atggtcagca tggacagata 1114621 atcagaaaac atgtttttgc tgaacagcct gtatgttgtt tctgtttgtg catataacat 1114681 gctgatgggg agagaaagca gcaaaagaag caggacaggc ctgtatattg taaagctcgc 1114741 ggacattttc ggggtaacag ctgggtgtag cggctttgtc tcaggcagtt tcagtgcagc 1114801 gatcagaaag tagataaaca atgctgcagc atctaatgcg aatatccaca cggggttatg 1114861 attgtacagc agcatcccca ctagcggtcc tgccgtcaga cccgtcgaat agatcgcatt 1114921 gatgaccgca aacacttccg aacgtctgct ttccggcgtg ctttcagcga tttgggcgcg 1114981 ggaagcggga atgtacaacg atcttccgat gccattcatg acatagagaa tagcgaaaac 1115041 atacgcatgc tcagcaaata caaaccctgt cattgccgct gattgaagaa gcaatgcggt 1115101 caaaatcgct gtgcgccgcc caagccgatc cgtcacccgt cctgcagcga gcgtcaggaa 1115161 aatatcagca aatggctgaa ggctgatgat cagcattggc atcatgatac tgccgtttaa 1115221 ttgttcatgc agatacagca ccataaaagg tcccatcatt gcacctgtca ggcttgtcag 1115281 caattcgccg aaaaagcgga gccgaacggg agcggtatat ctcgatttta tagagtgaaa 1115341 actggtcaac atgtgatcgc cgcctttcgc tgtttgatat agtagtagtg tatagaaggg 1115401 gcggcggccc aaaaagtgaa gaaaagaaga gataaaagtt ccccttttgt cgggaggtgc 1115461 ggggattgaa gctgatagag cactacgtgg cgcttgtaaa aacaggctgc gccgagtatg 1115521 ggcaaatgaa cgaaatgacg ctcactgaga ttgccgactg tttattttgt acagaaagaa 1115581 atgcaaagct cattttacat aagctggaga acagcaattg gattatccgg gaaagcgggg 1115641 cggggcgcgg ccgcaaatct aaaatcgcgt ttcttcggag gcctgaggaa ctgcttcttc 1115701 aaactgcaaa ggaatatacc atgtcaggaa agcttaaaaa ggcaaaggag ctgcttcagc 1115761 agtatcagtc cgcgtttcca gggcttcaaa acgaatataa catgtggcta tcagaggtat 1115821 tcggatttgt gacggagaca ggcgagaatg gggcgaagga tgtcctgcgg ctgttcatca 1115881 cgcctgaatc tgtcagcagt ttggatccat gccaaatatt tttgcggtct gagggccatt 1115941 tcgtcaaaca gatatttgat acactcttca cgtttgattc ggatatgcag gagccgaagc 1116001 ctcatttggt tcatggatgg gaagaggtcg gaaaaaaaca atggagattt tttcttcgaa 1116061 aaggtgtgtt atttcataat ggacagccgc tgacatcgcg ggacgttgcg tttacatttc 1116121 agcgcttttt ggaactggct gacaacccgt ataaatggct tctgcacgga gtgaaacaag 1116181 tcttagaaaa gggcccttat tgtgtggagc tcatactcga taagccgaat gcgcttttgc 1116241 cgtatgctct ttgtgatgaa cggctgtcca tactgccggc agaacagggc ggcgggaaaa 1116301 atggaacagg gccttttcag atgaatcagc aacatagcgg gatgcttgtg cttgaagcca 1116361 atgagcgcta cttcaaggga cgcccctatt tggatcgcgt tgagtttgtg ttttctgagc 1116421 aagccggaga gatgaacggt tttaccattc aagaaaaaca aacatgtcct gagcagcaaa 1116481 ctgtctttga tgagcggcat gttcagtatt tgtcgcttaa tctgaaaaag aaggggcctc 1116541 ttcagcaccg aagctttaga aaagcgctcc ggctgctgat ttcctctgaa cggctcgttc 1116601 gtgaagcggg agggcaccga agaattccgg ttacgtcctt tttgcatccg agtccttttg 1116661 agtgggaggg cgtttcgcca tctgaattgt tgaaaaaaag cggatacgag ggcgaaacaa 1116721 tcgtgcttta taccttttcg gaaacggatc atcgtgagga cgccgaatgg attcaaaata 1116781 tttgcgccca gcacggtatc aggcttacac ttcaattctg tgatgctgct gatctgcgac 1116841 ggccggaaat cgtgcagatg gcggatatca ttcatgacag tgcgacgttt tatcaagaca 1116901 gcgagtttgg ttttctgcat ttgctgctgt cggagaacag tttcttgtat cagcatctat 1116961 ctgaaaagct gacacagatt tgctcaggaa tgacagagcg gatgttttcc atgcctgacc 1117021 gctgttcgag aatcaacatc ctgcgtgaca ttgaccggca gatgatacag gagctgaacg 1117081 cgatcccgct gtatcaaaat gtgctccagg tgacatcaag taaaaatgta aaaggcctgg 1117141 tgcttgatga agagggatgg attgatttgt actccgtatg gctgtccaaa taaaaagagg 1117201 gttctttttt gaaccctctt ttttacgctg ccatgctgcg gcattgttca gcacaggtga 1117261 agcaggcttt cgcacatgct tggcaatgat catgatcgtg ctttccgcat tcagtgccgc 1117321 atgcttcaca aatatcggcg caaagtgcac aaatttcttt cataaacggg ctgtccgttt 1117381 gcatggcttt gaccgccagc gcgcaaatat ccgcgcattc cctgtcaagc cggatgcatc 1117441 cgctgagatg atgctgcacg ctttcttcca agcatttagt gaaacaatga ttgcaagcct 1117501 tcatgcaatc gatgcaagcc tcaatacaag cctcagaata ttgctccatg gttgattccc 1117561 cctgtatgac agtatatggt tttatgtttc acggctgcat ttgaaaaaaa caggggagtg 1117621 tgtttttagc taaggggata tgtacatata ccctgaatgg gtatatctaa cgttccatca 1117681 gatagtatag gaaccagaca gcgtgatttt gttcatcacg tgctgcgcgc gtaaagacgc 1117741 ctttcgcttt taagtttgac gtttcctcgg ccgcacgcaa gtaaaagtcg acggtttctt 1117801 gttcatcttt aaaagcggcg tccagtcctc ttgtgaaatt gtccgggcat tcttccgttt 1117861 gtttcggcat gatgtgtttg ccggtaattg aaccatacag tgtggaaaat tcacggaggt 1117921 ggcgaatctc gtcacgcctg atttcttcaa tctgttttct gacctcatcg ctgtgggcga 1117981 gttcggcaag cttgcggtag cattgaatag cactgaattc tccgttgatg gccttctgca 1118041 aattccgaat caaaacagga tcttcccggt atggcaccgg atagggatag tagctgtaat 1118101 gcaaggggat tcaactccat tcttaggaat tgggcttctg taaaagtata tgttgggcag 1118161 ggagagatgt gcggagataa tcagcttttt atatgtgaaa aggccgtttt taccaataga 1118221 tcagattggt cattttcgtc aacattcgat aaaatataga gagataaaaa gagaggggtc 1118281 ttctaatttg ggagcagagt ttttagtagg caggtccggg agtggaaaaa cgaagctgat 1118341 catcaacagc attcaggatg aattgcgccg ggctccattc gggaagccga tcatttttct 1118401 agtcccggat caaatgacgt ttttaatgga atacgagctt gctaaaacgc cagatatggg 1118461 cgggatgata cgcgctcaag tgttcagttt ttcacgattg gcctggcgcg tcctccagca 1118521 tacgggagga atgagcaggc cgtttctgac gagcaccggc gtacaaatgc tcctgcggaa 1118581 gctcattgag gagcataaac aggagttcaa agtctatcaa aaagcgagtg acaaaagcgg 1118641 gtttaccgca caggttgagc ggatgctgac agagtttaag cgctattgtc tggaaccgga 1118701 ggatatccgc cggatggcgg aaagcggaac ggcttccgag tatcgcggag aacgtgtttt 1118761 atctgaaaag ctccatgact tatcaattct gtatcagcaa atggaaaaaa gcctcgcaga 1118821 tcaatatctt cactctgagg attatttgac attgctggca gagcatatcc cgcttgcgga 1118881 agatataaaa ggcgcccata tctatgtgga tggcttttat cagtttaccc cgcaggaatt 1118941 cagggtgttg gagcagctta tggttcatgc ggagcatatc acgttttcgc tcacagcgga 1119001 caagccgtca tatgagcggg agccgcatga actggaattg ttcagaatga cggggaaaac 1119061 ctattaccgc ctgcatcaga aggcgaagga actgaatttg gacattacgt ataaagagct 1119121 gagcgggact gagcggcata caaagacgcc ggaattggcg catctagagg cacagtatga 1119181 agcgcgtccg gccattccat acgcagaaaa acaagaagcc cttactgtga tgcaggccgc 1119241 aaacagacga gctgagctgg aaggcattgc tcgggaaatt cacgccctag tcagagagaa 1119301 gggatatcgc tataaggatg tagcaattct tgcgcgccag ccggaagact acaaggatat 1119361 ggtgaaggaa gttttcgcag attacgagat tccttatttc attgacggaa aagcatctat 1119421 gctgaaccat ccgttaattg aatttatccg gtcgagcctt gatgttctga aagggaattg 1119481 gcgttatgaa gcggtgtttc gctgcgtgaa aaccgaactg ctattcccgc tcaatgaacc 1119541 gaaggccaaa gtgagagaac aggtcgatca gctcgaaaat tactgtatcg cctatggtat 1119601 taaaggcgac cgctggacaa agggcgatcg gttccaatac aggcgttttg tgtcattgga 1119661 tgatgatttt gcgcagactg atcaggaaat cgaaatggaa aacatgttga atgacacccg 1119721 cgattggatt gttccgccgc tttttcagct tcaaaaacgc atgaaaaaag cgaagacggt 1119781 tcaagagaag gcggaggcgc tctatcgtta tttagaagag acggatgtgc cgctgaagct 1119841 ggatcaggaa aggcagcgtg ctgaggatga cggcagaatc attgaagcgc agcagcatca 1119901 gcaggcgtgg gacgcagtca ttcagctgct tgaggagttt gttgaaatga tgggagatga 1119961 tgagatttct cttgatttgt ttcagcaaat gatagaagcc ggcgcggagt cgcttacatt 1120021 ttctctaatt ccgcctgcgc ttgaccaggt gtttgtcggc aatatggatt tgtccagaat 1120081 gtatggcacc tcctgcacct ttgtgctcgg ggcaaacgac ggcgttctgc cggcacgccc 1120141 tgatgaaaac ggggtcctgt cggatgatga ccgggaatgg ctgaaaacga ttggggttga 1120201 gctatcctca ggcggacgag agcgtttgct tgatgagcac ttcctcatct acatggcgtt 1120261 ttcaagtccg tctgaccggc tttacgtatc gtatccgatt gctgatgcgg aaggaaaaac 1120321 gcttttgccg tcgatgatcg ttaagcggct ggaagaactg tttccgcatc ataaggagcg 1120381 cctgttaaca aatgaacctg aacaggtcag cgatgaggaa cagctgatgt atgttgtgaa 1120441 taaaagcgtg gcacagtcct ttaccgcgag ccagctcagg ttatggactc gggaatacga 1120501 catcagcgac gtctggtgga gcacgtacaa tgtgctgatg agtgagcagg acaggctgca 1120561 atcgaaaaag ctgttctcaa gcctgttttt ccggaatgaa gtgaagcagc ttgaacgcag 1120621 cgtgtcgaga cagctctatg gtgaacgtat tcagggcagt gtatcgagaa tggaaacctt 1120681 taacgcatgc ccgttttccc attttgcgtc acacgggctg catttgaagg aacggcaatt 1120741 cttcaagctt gaagcaccgg atatcggcca gctgtttcat tccagcttaa agctgatttc 1120801 ggacaggctg cgtgagcaaa agctggattg gcgcgattta acgaaggagc agtgcgagct 1120861 gttttcctat gatgcggtag agcggctggc accgaaactg caaaaggaaa ttctgctcag 1120921 ctcaaaccgg cattattatg tgaaggaaaa actgcaaaaa attgtgacac gtgtgtccgg 1120981 cattttaagc gagcatgcga aagcgagcgg attcgtaccg atcgggcttg aactgggctt 1121041 tggaggaaaa gggccgcttc cgccgctgac ctttcaactg aaaaacggct gtacgatgga 1121101 actcgtcggg cgaattgacc gtgttgataa ggctgaaagc tcaaaaggcc tgctcctcag 1121161 gattgtcgat tataaatcaa gcgacaaagg ccttgactta gcggaagtat attacggatt 1121221 ggcactgcaa atgctgacgt accttgattt atcgattaca cattcagctg actggctcgg 1121281 gatgagggcg acgcctgccg gagtgctgta tttccatatt catgacccga tgattcaatc 1121341 taatctcccg cttgggcttg acgagattga acaggagatc tttaagaaat ttaaaatgaa 1121401 gggcttgctc ctcggtgatc aggaagtggt tcgcctcatg gatacaaccc ttcaagaggg 1121461 acgttcaaat atcataaacg ccggcttgaa aaaagacggc tctctcagat cagactcagc 1121521 agcagtcggt gaaaaggaat ttgatctttt gacaaagcat gtgcgccgca ccttccaaga 1121581 agcgggcgaa caaatcaccg acgggcgcgt atccattgag ccgtacaaaa tgaagaacaa 1121641 gacgccgtgc acatactgtg cgttcaaatc agtatgccaa tttgatgaat cactggaaga 1121701 aaacgagtat cgcccattaa aggctgaaaa ggacaagaca atacttgagt ggataaaaaa 1121761 ggaggcggat ggcaatgaac attcctaaac cggcagacag cacatggaca gatgaccaat 1121821 ggaatgccat tgtttcaacc ggccaggata ttcttgtggc agcggctgcg ggctctggta 1121881 aaaccgctgt gctcgttgaa cgaatgattc ggaaaatcac cgcggaggaa aacccaatag 1121941 atgtagaccg tcttctcgtt gtgacattta caaacgcctc agcggcagag atgaagcacc 1122001 gaatcgcaga agccttggaa aaagagcttg tacagcgccc cggctcgctg catattagac 1122061 gccagctgtc tcttttaaac cgggccagca tttcgacgct ccattccttt tgcctgcaag 1122121 tgctgaagaa atattactac ttgatcgatc ttgatccggg ctttcggata gctgatcaga 1122181 cggaaggcga gctgatcggg gatgaagtgc ttgacgagct gtttgaagac gaatacgcaa 1122241 agggcgaaaa ggcgtttttt gagcttgttg accgctatac gacagaccgg catgatctgg 1122301 atctgcaatt tctcgttaaa caggtgtacg agtattcccg atcccatccc aacccggagg 1122361 cgtggctgga aagctttgtt catttgtatg atgtatcaga aaagagcgcc atcgaggagc 1122421 tgccgtttta tcaatatgtc aaagaagata ttgcaatggt gcttaacggg gcgaaggaaa 1122481 agctcttgcg cgcgcttgag ctgacgaaag cgccgggcgg cccggcgccg cgtgctgaca 1122541 attttcttga tgatcttgct cagattgatg aactgattca gcatcaggac gatttcagtg 1122601 aactatataa gcgggtgccc gccgtctctt ttaagcgtgc caaagcagta aaaggggatg 1122661 agttcgatcc agcgctcctt gatgaggcga cagatttgag gaacggcgca aaaaaactgc 1122721 ttgaaaagct caaaaccgac tacttcacgc gaagtcctga acagcacttg aaaagcctag 1122781 ccgagatgaa gcctgtcatt gaaacgctcg tacagcttgt catcagctat ggaaaacgat 1122841 tcgaagctgc gaaacaggaa aaatcaatca tcgatttttc ggatttggag cattactgtt 1122901 tagcgatttt gacagctgag aatgacaaag gtgaacgtga gccgagcgag gctgcaaggt 1122961 tttatcagga acagtttcat gaggtgctcg ttgacgaata tcaggatacc aacctcgtgc 1123021 aggaatcgat tctgcagctc gtcacaagcg gtccggagga gactggtaac ctgtttatgg 1123081 taggagatgt caaacagtcg atttatcgat tcaggcttgc ggagccgctt cttttcctct 1123141 ctaaatacaa acggtttaca gagagcggag aaggcacggg gcggaaaatc gatttaaata 1123201 aaaatttccg aagccgggct gatattttag acagcacaaa ctttttattt aaacagctga 1123261 tgggcggcaa aatcggtgag gtcgattatg acgagcaggc tgagctgaag cttggtgcag 1123321 cgtatccgga caatgacgag acggaaacag agctgctgct gatcgacaac gcagaagata 1123381 cggatgcaag cgaggaagca gaagagcttg aaacggtgca gtttgaggca aaagccatcg 1123441 ctaaggaaat tcgtaagctg atttcatcgc cgtttaaggt gtatgacgga aaaaagaaaa 1123501 cacatcgcaa tattcaatac cgagatatcg tgattttgct ccgttcgatg ccgtgggctc 1123561 cgcaaatcat ggaggagctg agagcacagg gcataccggt ttacgccaat ttaacgtcag 1123621 gctattttga agcggtcgaa gtcgccgtcg cgctttctgt gctgaaggtg attgataatc 1123681 cgtatcagga tataccgctt gcctctgtgc tgcgctcacc gattgtcgga gcagatgaaa 1123741 acgagctgtc tttgatccgg cttgaaaata aaaaagcgcc gtactatgag gcgatgaaag 1123801 actacctggc tgctggtgac cggagcgatg agctttatca aaagttaaat acgttttacg 1123861 gacatctgca aaaatggcgc gcgttttcga aaaaccactc agtatctgag ctgatttggg 1123921 aagtgtaccg cgacaccaaa tatatggatt atgtcggcgg catgccgggc ggaaaacagc 1123981 gccaggccaa tttgcgtgtt ctttatgaca gggcgcgtca atatgaatca acggcatttc 1124041 gcggcttgtt ccgtttcctg cggtttatcg aacgcatgca ggagcggggc gatgatcttg 1124101 gtacggcgag agcgctcagc gagcaggagg atgttgtccg cttaatgacg atccacagca 1124161 gcaaagggct cgaatttcca gtcgtgtttg tagcaggtct cggccggaat ttcaacatga 1124221 tggatttgaa caaatcgtac ctgctggata aggagctcgg atttggcacg aagtatattc 1124281 atccgcaatt acgcatcagc tatccgacac ttccgctcat tgcgatgaag aaaaaaatgc 1124341 gcagggagct gctgtcagag gaattgcgtg tgctctatgt tgcattaacg agagcgaagg 1124401 aaaagctgtt tctgattggc tcatgtaagg atcatcagaa acagcttgca aaatggcagg 1124461 catccgcgtc ccaaactgat tggcttctgc cggaatttga ccgctatcag gcgagaacgt 1124521 atctagattt cattgggccg gctcttgcca ggcacagaga cttgggggat ttggctggtg 1124581 tgccagcaca cgctgacatc tcaggtcacc cggctcgttt tgccgttcaa atgatccatt 1124641 cctatgattt gcttgatgat gatctggaag aaagaatgga agaaaaaagc gagcgcctag 1124701 aagcgatccg ccgaggtgaa ccagttcccg gctcgtttgc gtttgatgaa aaagcccgcg 1124761 agcagctgag ctggacctac ccgcatcaag aagtgacgca aattcggaca aagcaatcag 1124821 tttctgagat caagagaaaa agagagtacg aggatgaata cagcggcagg gcccctgtaa 1124881 aaccggctga tggaagcatt ctgtacagac gtcccgcttt tatgatgaaa aaaggcctga 1124941 cagcggcaga gaaagggact gccatgcata cggttatgca gcatatcccg ctgtcacatg 1125001 tgccgtcgat agaagaagct gagcagacgg ttcacaggct ttatgaaaaa gagcttctca 1125061 ctgaagaaca aaaagacgct attgatatag aagaaatcgt gcaatttttc catacagaaa 1125121 tcggcggaca gctgatcggt gctaagtgga aggaccggga aataccattc agcttagcgc 1125181 ttccggccaa ggagatctat cctgatgcac acgaggcaga tgagccgctt ttagtgcagg 1125241 gtattattga ctgtctctat gaaactgagg acggattata tctattggat tataagtcgg 1125301 accggattga gggcaaattc cagcatggat ttgaaggagc ggccccgatc ttgaagaaac 1125361 gatatgaaac gcaaattcag ctgtacacga aggcagtgga gcaaattgca aaaacaaagg 1125421 taaagggatg tgcgctttat ttctttgacg gagggcacat tctgacatta tagcgagatc 1125481 cataagctcc ggaatttcag gcggagcggg tctcgttttc tatataaaag agaggtgaaa 1125541 gcatttgcgg attttacata cggctgactg gcatcttgga aaaacgcttg aaggaagaag 1125601 caggctgagt gaacaggccg atgtgctgga tgaactgaat acgattgtaa aggatgagca 1125661 gatcgatgcc attgtaatgg cgggggatgc atttgacacc gtaaacccgc cagctttagc 1125721 cgagcagctg ttttatgaaa gcctgtctgc gcttagcgac agaggaaagc gcccgatcgt 1125781 cgtcattgcc ggaaatcacg ataatcctga ccgtttgtcc gccgcttcac cgctgacaca 1125841 tgaaaacggc attcatttaa tcggttatcc gacaacagag ccgattcata ttgaagtgcc 1125901 ttcagcagga gagcttttgg cggttggagc gctggcgtac ccatctgaag cgcggttaaa 1125961 tgaagtgcta tccgatacgt ttgatgaaaa gctgctccgt gatcactatg atgtgaaaat 1126021 caggcaggcg tttgagcata tgacaagccg gttccggacc gatgcagtga agattgccgc 1126081 cagccatatt tatgtggcag gcggaaacca aaccgattca gagcggccga ttgaagtcgg 1126141 cggtgcatac acggtggctg ctgaaagcct gccggcagat gccgcttacg ttgcgctcgg 1126201 ccatttgcat cgcccgcaaa cgatcaagcg ggcgcggacg cttgcgcgtt attcaggatc 1126261 tccgctcgcc tacagctttt ctgaagcggg ctacgctaaa tcagtgacga ttgtggacgc 1126321 aaagcctggg gaagaggcca cttggcaaga ggtgttatta tcaagcggca agccacttgt 1126381 gaagtggaaa gcggcaaatg gattaagtga ggtgtacagc tggctggatg aaggcagaga 1126441 tcagaatgct tggattgact tggaaatccg tgtcgcggac cagctgtcac ttgaagagat 1126501 tcacaggctg cggaaggcgc acccgggctt tatccatatc aggccggttt ttgaagaaca 1126561 gaacaaagac cgggaacgga tcgaggttaa acatgtctca atcgaggacc gctttaagaa 1126621 attttatgaa aaacaaactg gcggtgcggt gccggatgaa gaaatggtga agctgttttt 1126681 agagcttgca tcaggcgttg aagaggagga tgcgaaatga agccgatcgc cttaagcatt 1126741 aaggggctcc acagctttag agaggagcag acgatagatt ttgaaggcct ttccggtgcc 1126801 ggtgttttcg gcattttcgg cccgacagga agcggtaaat cctctatact cgacgcaatg 1126861 acgcttgctt tatacggaaa ggtggaacgg gcggcgaata atacgcacgg aatcttaaat 1126921 cacgccgaag atacgctgtc tgtgtccttt acctttgcgc ttcagacgaa tcaccaaatc 1126981 tcatacaaag tcgagcgtgt gtttaagaga acggatgaaa tgaaggtaaa aacggcactt 1127041 tgccgcttca tcgaaatcaa ggacgagcat acggtgctgg ctgataaagc cagcgaagtg 1127101 aataaaagag tggaggagct cttagggctg acgatcgacg attttacgag agcggtggtg 1127161 ctgccccaag ggaaatttgc tgaatttctg tctttaaaag gggcagagcg caggcatatg 1127221 cttcagcgtt tatttaattt ggagcaatat ggagacaggc ttgtgaaaaa gctgagacgg 1127281 caggcgcagg aagccaatgc gagaaaaaat gaaatgcttg ctgaacagtc cggtctcggt 1127341 gaggcgagct cagaggcagt ggagcaggct gaaaaggttc tcgaacaagc tgaagcccgg 1127401 ctggaagcga tgaggaagaa ccgtgatcag gcgaaggagc ggtttacaga gcatcaggag 1127461 atatggaatg tccaaaagga aaaatccact tatgaagaag aggaaaaacg tctcgcagaa 1127521 gaacagccgc atatagacag catgcaaaaa cgcctgctgg aagcagaaac agcagcagcc 1127581 cttaagccct atgcggaccg gtacgcagaa gcgatccagc atgaggagca agctgaaaag 1127641 gaacaaacgc tagcccaaaa ggatttagca gaccggacag ctttctttca gcaaaaacat 1127701 gaagagtatg aagcgtggcg ccagcataaa agcgagaaag agcctgagct tttagccaaa 1127761 caggaacagc tttcacgctt gcaggaaatc gaaatcaaac tgagtgaggc caagcaagag 1127821 gaagagcgca aaaaggctga cctccggcag aaagaagagg ctcttcaatc tgtcatgaat 1127881 gaattagaga ccgtaacaga ccgcctgaca cgagggcaaa acagacagac agaattgaag 1127941 cagcagctca aatccctgca ggtgacatcc gatgagcgaa aaagctgcca gcaggccgca 1128001 gagatggcat tgcgcatcag acaaaccgag gaacaaatca aaaaagagaa aaaacgaagt 1128061 gaagaattga acctcgtgct gcagaagatg aatgaagaga agaatacact cgttcaaaag 1128121 acggaagcgg aagaaaacaa catcattcag gcatatgagg cagttcaaac tgtgtaccat 1128181 ttggtgtgcg aaacggaacg ctcattaaca cgtatgacgg aagaggctag aaagagtcaa 1128241 cacacgcttc acttacagcg tgaaaaagca agggtggcac tgctgacaaa agagttagcc 1128301 caaaagctga ctgccggaaa gccttgcccg gtatgcggtt caaccgatca tgatccatct 1128361 gcctcggtac atgaaacgta tgaagccgac agccatcttg aagaggacat caaacggaca 1128421 gatgtgttat tgacggaagc tgcagctctc agccaggaga ttctttcagc caaaattatg 1128481 cttgaagaac agtccgcgcg ctttattgaa cagtgtccgt ttttgcagac aattcaagca 1128541 cagaaccttg aagcggcagc ttccttcgaa catcagccgg tgtatgaagc atttgaaact 1128601 gccaaatttg aatggaaacg aatcaagcag gacattcttt ctgttaagac acgaatggca 1128661 caaatgattg gcgcctatca ggagtcttta aaaaaggccg agcagcttaa tgaaaaaatc 1128721 ggttttgaaa aaagagaagc cgaccgtatt gaaagcatca tcagtgagct tcaatcctca 1128781 atggacagca gtctgaacat gtttaaagaa gcatttcaga atcaatctgt ggacgaagca 1128841 gaaaaatggc agcaagccat tgaagaaaag gaccgggctg cagaagaatg tgaaaaacga 1128901 attgagaaga gtatcgcgtt tcttgctgag catgaagcac aaaaggaaaa actgcgggaa 1128961 tcgggacacc ggcttgagcg ggaaaagctg gagcttcatt atgcggctga acgcatcaag 1129021 agcgtgatag ctgattatga gcacgaactc ggagattatg caaaaggaga ttcgattcaa 1129081 atcaaactcc gctctgtcca gcaggatcta aagctgttaa aggaaaaaga acaatcttta 1129141 tatgaagaac tgcaaagcgc ccaaatgaag ctcaaccaag cgaaaagccg cgcttctgca 1129201 agcgagctca ctcttcaaga ggcgaagggc agattggaaa aagcaaaagc tgcttggctt 1129261 gagcatacaa aaaacacctc cattacccgg actgaggagg ttgaacaaag tctcatccca 1129321 gctgatgaac ttgaaaagat gaaaaccggc atagaccagt ttatggataa actgaagcaa 1129381 aatgctgcaa acttaaaacg agtagcagag atacttgccg gcagagcatt atcagagagc 1129441 gaatggaacg aaaccgttgc agcattacaa gaagctgagg acgcatttgg cgctgctata 1129501 gaggaaaaag gcgcggccgc aaaagcactg gctgtcattc gcgaccatca taaacggttt 1129561 aatgaaattg aagctgaact gaaaaaatgg cagatgcata tcgacaggct ggacaagctg 1129621 caagctgtgt ttaaaggcaa taccttcgtc gaatttttag ctgaggagca gcttgaaagc 1129681 gttgcgaggg acgcctcagc aagactcagt atgctgacaa gacagcgcta tgccatcgaa 1129741 gtagattctg agggcggctt cgtgatgcgg gatgacgcga atggaggcgt acgacgcccg 1129801 gtttccagtt tgtctggagg agagaccttc ctcacctcgc tttcacttgc tcttgcgctg 1129861 tctgcgcaga ttcagcttcg gggggaatac ccgctgcagt tctttttctt agatgaaggc 1129921 ttcggcacac tggatcaaga tctgcttgat acggttgtaa cggccttgga aaaacttcag 1129981 tcagacaacc tggctgtcgg tgtcatcagc catgtgcagg aactgcgtgc acggcttccg 1130041 aaaaagctga tcgtccatcc ggctgaaccg agcggccgcg gtacgcgggt atcacttgag 1130101 ttgatgtaag ggaggagcgg atatggcaaa gcagattgcc ggaatatgtg agctgtgcgg 1130161 ccggagcgat gtccagctga cagagcatca tcttacaccg aaagaggaag gcggaacgtt 1130221 tttgccgaca gcgatgctct gtattccttg tcataaacag attcatgcct tatataccaa 1130281 tcaagagctc gctgtacgtt taaatggaat ggctgaactc agaagcgatc cagagcttgc 1130341 ccggtttgtc aaatggatca gaaaacagcc gcctgagaag ctgatcaaaa ctaagaaatc 1130401 aaatgaacga aaaaagaaaa aatgactaaa aagcagccct ctctttgcag agcggctgct 1130461 tttatccgtt tccaaccata tcctgatcgt tgacatcggg gtctatataa tttgtcgcgt 1130521 tgactgcatt atttaataga aggaaatctc ccgtgtttcc tgctcccgaa ccgagcgcag 1130581 attttgaaga gcttttcgga gaaaggtaaa aggaatcacc aaagtttacg actccgcccg 1130641 atatggaatt gatagctata ggcccgacaa ttgctggcat aaacgacacc ctttatcgaa 1130701 gtctctgttt attatatgtt cttggcgggc gattgtgagc gcggagactg aatctgtctg 1130761 atatgtttga gtctcgcatc accgcgaata agcgaagctg atccggcatg taaaacagaa 1130821 gaggctgaga ccccttgaat tttgatgctg cgaacataaa tagccggcac ctcgtggcaa 1130881 aacgcgcttt gtacacctgt ttcggggagc ggcttcacgg cctgctgctg aaagatctga 1130941 tactcctttt tgttaaatga gccttcatta tggtaaaacg tggacagaga acgctgcaca 1131001 gcaaatactt ttacactcat atcgatttca tttgtgtcgc caacttgaaa cacacttgcg 1131061 atcccgagag aattaaactt aactagtctg atgcgcgata tgcgtttaag cattattctg 1131121 gcgcaagcgg agcaaacggc ccaataataa gagattcagg cggtgtatca aaaatagaag 1131181 acaggtagat ggattcagtg tctccgatgt ggaaaacgga ggaactggac acaccgttca 1131241 tccgaatatc cccgacttcc aagctgcggt tgatgactgt aaagatcatg cttgctcatc 1131301 tcctttcatt tctgatggaa tatgctccag aaagtgttct acagcgcgga tgacatcacg 1131361 cttcacatgc tcagcgatat gttctgcata ttgtgcaggc ggtgtatttt cttctttttt 1131421 gatatgggac atataatagt gaatcctgct gtccatttgt tttctgatgt cttcaataac 1131481 atgatgtctg tttgtatcgt caagtctgct gtcatattga ttttcaagct gttccaaaat 1131541 atctgggatt tcctcggtta agtacatgtc gacattctgg cggatctgct gcatgagctg 1131601 agcgctctct tcctgctgca tcatcccgat ttgcggtgtc gactggctga cgtcaaagtt 1131661 ttggacgctg ttcgggtcag tcggatttaa accgatattc aaagtcccgt cgagcctttc 1131721 gattttcagc tgatcaaatt tatactccac acgctcaatg gtagtggccg gccgctgttt 1131781 catcgtattc atttcagttt gaatctcttt cagctgacgt tcgagctgct gaatgtgaat 1131841 cgcctgctgc tgaacgaagg aattcaagtt ttgcaggtaa gaggaaacag attgatcata 1131901 catgttcttc acctctttca tatgattaac ggccaggagg ctggagcggg accaatgaac 1131961 ctgtgtcggg ctcctgcagc tggagcggtt gccctgagcc agaaacttct ggtgccggct 1132021 ctacatagct tcctgtatta tacaaatttg acagtgactt gattgatccg gcgctcccga 1132081 tttgcagaat ggaggagttg ctgattgatt ccagccggag atagttgatt tgaatggttt 1132141 gattaatata gaagttcatg agcctcactc cttttacgca ttggccacga tcggctgatc 1132201 aaccgcatca ttgtcataca cattcgtcgc gttttgataa ttcatcacct tgaggctgtc 1132261 gccggtatta aagctgccag caccggcaaa cgttctgacc tgagcctgag gagaaatcgt 1132321 aatgcagtcc ccgatgtgaa cgactccgct cgtaccaatc gcattaattt taaacgctcc 1132381 gacaatggcc ggcatacgag cacatccttt gttgaaaaat taaaaaaaga caggtaaagt 1132441 gaaatgacaa ttccgatttc aattgggcta ttcacgatag cttatgacaa acgcacatat 1132501 gtgtgagaga aattttaagg ggacatatcg gctctttgtg aaagcgtttt attttttcgg 1132561 gccgttatgt ttaaacatgg caaaagagga tgttgggtat aaattgagcg gaaatgcggc 1132621 gaaggatgcc gctatccgcc tatggtgatt tttgtttatt tctttggtgt ttttgcgtgt 1132681 agaatgcttt ttggagtatg tcgtgctgcg gtattcgatt tttgggcggg cacattctcg 1132741 ccctgaggta tatctcagaa gtgctgagca aaaatcggag ttaaatgtgg tgtattctaa 1132801 ttgttataga aaatgattta catacgggag ttttcaagat atctcccaaa aatcatttct 1132861 tctttaatcc gggtattcag caggatatcc agctcttggc tgcattgaat cgtttctttt 1132921 gaattcatgc cgtatttttg tgcggtttca attagtgtga tcctcatttc ttcaatttta 1132981 ctgttcatta cgctatctcc aattctagat tttattttga tataaataca ggatatcgtt 1133041 agtataacct attttggctc aaaaggttgc ctttcgtcaa tttgactaaa aaagcgacaa 1133101 tttttgctgc ggcctttttt aatggagaaa ggactaaagt cttgctaagt gtgcttgcaa 1133161 aaagtcctgc cgttcctcaa tttctctaag tatgttggtc tgctcctttt cgatttgaaa 1133221 ggggcttttt ttgataaaag gatcatcagc agcactttga caaatgtcaa ggtgccattc 1133281 gttgatgaga ggagataatc gttcaatagt aaacgaccgc ttcagcacgt ttttcattaa 1133341 ggtgtgatat tgcgacctga aggcgggaat ggatagaagc cttgacgaaa gcgtctttcc 1133401 ttttgtcaga agcgggtctt cttcatacca ttcttgtacg gcaagcgatc ttgtctccat 1133461 cggggaaacg taaagccgac cggattcgtt taaacaaaat gtgtagtaaa agccttgatt 1133521 ggtgcaggtg ttgccgatca gccacaaaaa aaacagcttg acatccagat acaatttaat 1133581 cctttcagcc aattcgtcat ctccggctgt gcggatcagt atgaaaaatt catgtaagaa 1133641 tgccgaggaa tcattgttaa aaagggacaa tggaaccctt ggatcggccg tcttcactcc 1133701 gtaactcctt ttaccggctg gctgatggtt cttgatgttc aaataaatgc cttcaggctg 1133761 gccattgatg gtcagaaagc tgtacgaggc aacgggagca ggtacgccga tctggtcaaa 1133821 aaaacaatag gcgagtctgc gccgcatcag ggacggatca tcctgttctg cattcaaaaa 1133881 aagtgtcctt tcaccaagca gagacttttc ccagctgatt tcataggatg ccttttccgc 1133941 tctgtcacgc tgtgtgagaa gaatgggaga aacagatcga tctgttacga aaagcccctt 1134001 ggctgtacct ttccttttca gctgctcccg atgaaaaaat aaatgcacgc gctccatatt 1134061 ctttcctcct tctcaaaacg acatttgtat gatatgtaga gcaagcccgt cctgaaacga 1134121 aatgaaaacg gaattgagaa aaagggattt cagcattcga cagagaatac atgaaggagc 1134181 attctgattt aaaagatgat ggaggaataa catgaaattt gcgacagggg aactttacaa 1134241 ccgaatgttt gtcggcctga tcattgacga tgagaaaatt atggatttgc agaaggctga 1134301 aaaaaaactg tttgaacttg agacgattcc gggatcgctg attgaatgta tcgcagaagg 1134361 ggataaattc gttgcgcatg caaggcagct ggccgagtgg gcaaagaaac cgaatgatga 1134421 gctgggatca tttatgtatt cattatctga ggtgaagctc catgcaccca ttccgaagcc 1134481 atcaaaaaat atcatctgca tcggcaaaaa ctaccgggat cacgcgattg aaatggggag 1134541 cgaggctgat attccggagc atccgatggt atttacaaaa tcgccggtaa cggttacggg 1134601 gcatggtgat atcgtaaaga gccatgaaga ggttacctct cagcttgatt atgagggaga 1134661 acttgctgtc gtgatcggaa aaagcgggac tcgcatttca aaagaagatg catatgacca 1134721 tgttttcgga tatacgattg tgaatgatat cacggcgcgt gatctgcaaa aaaggcataa 1134781 gcagtttttt atcggaaaaa gcttggatac gacatgtccg atggggcccg tgcttgtaca 1134841 taaatcatct attcaggagc cagagcgcct caaggttgaa acaagagtca acggcgagct 1134901 gcgccaatcc ggttcggcaa gcgatatgat cttttccatt ccggaattaa ttgaaaccct 1134961 ctcaaagggg atgacgcttg aagcgggcga cattattgcc accggtacgc cgtctggtgt 1135021 cggcaagggg tttacgcctc caaaattctt gcggtcaggt gacaaaattg atattacaat 1135081 tgatccgatc ggaacgctgt caaaccaaat tggctgaata aaactggagg gcggacccgg 1135141 acccgcccgt tttttctgat aatcatcttt gtgacagagg acaagttcat ggtactataa 1135201 gtggggtaat ttatctgata gggggaacat atatgacaca cctacatatt acgacatggg 1135261 tggtagcgct gattctgctt ttcgtcagct actcgctgta ttcgtcagga agtgcaaagg 1135321 gcgcaaaaat cactcatatg attctgcggt tattctatat ccttattatt ttgacaggag 1135381 ctgagctgtt tgtccgtttc gccaactgga acggagaata cgccggcaaa atgattctgg 1135441 gcattatcac catcggcctg atggaaatgc tcctcatccg caagaaaaaa gaaaaatcaa 1135501 caggaggcct gtgggtcggc ttcgtcattg tccttttgct gacagtgctg ctcggtctgc 1135561 atttgccaat tggttttcaa ttgttttaat agaaaaacct atgaacccgg ctctttgata 1135621 gagctggttt tttttatatt tatcccctca tattccaaat catttaaaat aaccttaaaa 1135681 ttccctgtaa gcggtatctc gtcctatgaa attatgatac cttcaaggag attcattatt 1135741 ttgcaggagg gataacatga aacgcagaaa attcagctcg gttgtggcgg cagtgcttat 1135801 ttttgcactg attttcagcc ttttttctcc gggaaccaaa gctgcagcgg ccggcgcgat 1135861 cgatcaggcg gctgctctgg aaaacggcaa agagcagaca ggcgccatga aggagccgga 1135921 acaggtgaaa tggtacaaag tgaccccggg agcaacggat attcagaaaa actcacatat 1135981 ggcactgacc gtaaagagtg attcagtact gaatgtatct gtatatccaa gtaaggaaaa 1136041 agcgcttaaa gatgagacgt ttgagatgta ccgttctttc acagcggagg atggaaaaag 1136101 cgaagtcatt tttccatacg cgtggagcgg cccttactat gtaaaagttg aatacctcgg 1136161 agaagaagaa ccagaggacg gcggaacggc agaagcagct gcagaagcca agtatacgat 1136221 tgggtataaa ggcaccaaaa aacagccgtc agatttagaa gaggaagaag cttgtccggt 1136281 tgaaatgagt gtcgatcaga agaaatcagg aaaaggcatc ctggataagt tgagatcgat 1136341 tcgtgatgag cagctgagcc aaacagcaga aggcaaagaa ctgacaagcc tttattacaa 1136401 agcagcaccg tttatcgttg caaagctcgc actcaataaa acagcaagaa atgaaatcta 1136461 tcaggatctt gtgacattaa agccgttatt tgacgatgtg tcagaaaacg gagcatcatc 1136521 ttcgtataag gtcactgaaa aggatcaaaa agcgatcaac cggctatatg ataaagcttt 1136581 acaatcagtc ccgtcattcc ttaaagagga gataaagaaa caagcggacc gactaaatat 1136641 gaagcagctg caaggcaaaa cagcaggagc cattttaaca gaaaacaata ttgcagcaaa 1136701 aagtgaagtt cagacaacaa aggttatttt caaggtgaag gacaataaaa gcctctcatc 1136761 cgtacataat gaaatgaagg gcttttctgc aagcgcgcaa tcgaaaaaag acatatctaa 1136821 tgtgaaaaag gcaaagaaac tgtttgacaa tctgtattca tttgaacttc cgaaagacga 1136881 gaaacagaac ggcgcatata cggcaagcgc caaaagggtc aaaagcgctg ctgcgacact 1136941 atccaagatg tccaatgtag agtttgcgga acccgtacag gaatacaaaa gcttggcaaa 1137001 cgatattcag tacccttatc aatggccgct taaaaacaac ggtgaaaacg gcggtgtcaa 1137061 aaatgcggat gtgaaatatg agcctgccaa cacattgctg tccaaacgca agcttaacga 1137121 tacactcatt gcagtagtag acacaggcgt agacagcacg cttgccgatt taaaaggaaa 1137181 agtaagaaca gatctcggac acaattttgt cggacgaaat aacaatgcaa tggatgatca 1137241 ggggcatggg acgcatgtcg caggcattat tgcagcccaa agcgataacg gctattcaat 1137301 gactggattg aatgccaaag caaaaatcat ccctgtaaaa gtgcttgatt ccgcaggttc 1137361 cggagatact gaacaaattg ctctcggcat caaatatgct gctgacaaag gagcaaaggt 1137421 gattaattta agtttaggcg gaggctacag ccgcgtgctt gaatttgctt tgaagtacgc 1137481 agctgacaaa aatgtcttga ttgccgcagc cagcgggaat gatggagaaa atgccttatc 1137541 ttatcctgca tcttctaaat atgtgatgtc agtcggcgca acgaatcgca tggatatgac 1137601 cgctgatttc tctaactatg gaaaaggtct ggacatctct gctccagggt ctgatatccc 1137661 gagcttagtg ccgaacggaa atgtcacgta catgagcgga acgtctatgg cgacgccata 1137721 tgctgccgcc gctgcgggac tgctgtttgc tcaaaatcct aagctaaaaa gaacagaagt 1137781 tgaggatatg ttgaaaaaga cggcagatga tatttccttt gaaagtgtcg atggcggaga 1137841 agaagagttg tatgacgatt atggcgatcc gattgaaatt ccgaagacac ctggtgtaga 1137901 ctggcattca ggctacgggc ggctgaatgt catgaaggct gtcagcgcag ctgatttaca 1137961 gcttaaggtc aacaagctgg aaagcactca aacagctgtc agaggaagcg cgaaggaagg 1138021 cacccttatc gaggtgatga acggcaaaaa gaaactcggc agcgccaaag ccggaaaaga 1138081 caatgcgttc aaggtgaata tcgcgactca aaaacaggat caagtactgt atctgaaagc 1138141 aacaaaaggc gatgcgaaaa catcgtataa agttgttgtc gtcaaaggaa aaccttccgg 1138201 cacaccgaaa gtaaacgcgg tgaaaacgaa ggatacggca gtaaaaggga aggcaaacag 1138261 caaagcgatg atcagagtga aaaacaaatc aaagaaagtc attgcttctg ccaaagctga 1138321 cgcaaaagga acgttttcgg tgaaaatcaa aaaacaaaaa gccggaacgg tgctgtacgt 1138381 cacggctgtg gatacagata aaaaagaaag caaggaagca aaagttgttg ttgaaaagta 1138441 accaaaaagc ggtgctcgat gcaccgcttt tttatttgcg cccccgttgg actgctgtgt 1138501 acataatgga tcgctttccg tttgaagccg tccattcaaa acggtctcct gtcccttcgc 1138561 tgctgtagtt gtagtgatgc tgcatcgcgc attgtgcggt gtcatttgaa aagtgataaa 1138621 aggacacacc ctgccccgcc gaagtattcg aaaagactcc tttattataa gaaaagacgc 1138681 aatcgaatac cgataagccg aagctgtgca agtgctgcag aaatgcgaga aaggtttcgt 1138741 cgtcaagcga atccaaaagc gccatgagcg gccgcttgac tgatttctca tagcggatgc 1138801 gttctccgcc ggaaagggag atgttttctg caccgcatgc caaaaccaac ttgtcctgaa 1138861 agccggcttg ctcccacttt cctttatgat ggatccagat tgggctgtgt tggagactgt 1138921 ccgccagcag tatatcgcct tcaccgtttt cgattaagca gatgccgtct tcaatgagga 1138981 tggtgccgta ttcccacttt cgttcctctg tatataacaa ttgtttccgt ttcatccatg 1139041 ctgtctcctt tttcttcatt cctctctttt ctttccaatt caagcctgtc ccatacaact 1139101 cttttatgga caaatcaact atctgcctat agatgcataa acttactaag gtgctgaaag 1139161 aaacgaaatt gttacgaaag aaacgggatt ggagctgatg tcacatgtgt ggaattacgg 1139221 gttgggtcga ttttaaaaag cagctcgtcc aggaaaaaca aacgatggac agaatgacag 1139281 acactctttc caaacgaggg cctgatgatt caaacgtttg gggggagcac catgttttat 1139341 tcggacataa aagacttgcg gttgttgata ttgaaggcgg acgccagccg atggcgtgta 1139401 cctataaagg cgatacgtac accattattt acaatggcga gctttataac acggaagatt 1139461 tgcgcaaaga attgcgggcg cggggccatc aattcgagcg tacgtcagat accgaggtgc 1139521 ttctgcacag ctacatcgag tggcaggaag actgtgtcga ccatctcaat ggcatattcg 1139581 ctttcgctgt gtgggatgaa aagcgtaatc tgttgtttgc cgcgagagac cgtctcggtg 1139641 taaagccgtt tttttacacg aaggaaggct cttcatttct cttcgggtcg gaaatcaaag 1139701 caatcctcgc gcaccctgat ataaaagcgc gagtggacag aacgggactt tctgaaattt 1139761 tcggtcttgg accgtccaga accccgggca ctggcatatt taaaggcata aaagaaatcc 1139821 gcccggctca cgcgctgaca ttttccaaag acggacttaa tatttggcgt tattggaatg 1139881 ttgaaagcga aaaacatacg gacagttttg atgacacggt tgccaatgtc agatcgttat 1139941 ttcaggacgc ggtgacgcgg cagcttgtgt cggatgtgcc tgtttgcaca ttcctatcag 1140001 gcggtctgga ctcaagcgcg attacagcga ttgcggcggg ccattttgaa aaggaaggaa 1140061 aagcaccgct tcatacttat tcgattgatt acgaagagaa cgataaatat tttcaagcaa 1140121 gcgcttttca gccgaatgat gacggaccat ggattgaaaa aatgacagag gctttcggca 1140181 caacgcacca caaatgcgtc atcagccaaa aagacctcgt tgatcatttg gaggaagctg 1140241 tactggtcaa agacttgccg ggaatggcag atgtcgactc atccctgctg tggttttgcc 1140301 gggaaatcaa aaaggacttt gtcgtcagcc tatcgggaga atgcgcggat gagattttcg 1140361 gcgggtaccc gtggttccat acggcagatg ttgagtctgg ctttccatgg atgagatcaa 1140421 cggaggagcg gatcaagctg ctttctgact catggcagaa aaaattgaat ctgaaagaat 1140481 acgtaaatgc caaatatgaa gaaaccttgg cagaaacgcc attattagac ggagaaacgg 1140541 gtgtggataa agcaagaaga cagctgttct atttaaatat gctttggttt atgacgaacc 1140601 ttttggatcg gaaggatcgc atgagcatgg gggcgagcct ggaagtgcgg gtgccgttcg 1140661 ccgatcaccg gcttgtggaa tatgtttgga atattccgtg ggaaatgaaa atgcatgata 1140721 atcgggaaaa aggcattttg cgcaaagcgc ttgagggcat tttgcctgat gacattttgt 1140781 atcgcaaaaa aagcccatat ccgaaaacac atcatccgga atatacaaaa ggcgtcagcg 1140841 agtggctgaa aacgatcaga agccaaaagg actccgtgct ccatacctta ctggacagaa 1140901 aacaattaga tcagctttta gaaacggaag gctcctcctt caaggtcccg tggttcgggc 1140961 agctcatgaa ggggcctcag ctgatcgccc atcttgctca aattcataca tggtttgaag 1141021 cgtatcgcat tgatattgac gagaggtagg ttcaatacaa atgtgattaa aagccagaga 1141081 tgtatagatt taaataagaa ggatagatga gcagggaaat atatgctcta tctatccttt 1141141 tttgtacaac agcactatcg aattgccccc gcattccttc aataagaatg aataggtttt 1141201 aatgttctgc cgataaaact agctgatacc gggcttaact ttaattccct agcccataca 1141261 gaaagttgac caatatggtg aatttcgtga gcgatgatat ggtgtaatat ttcatctcgc 1141321 gtatataaaa cacctgtctc ccaaggaacg cttacaagtt catcttttat ttgatctgaa 1141381 tgtgtttgta aaacatcaat tatttcagtt cggaatgtat ttgagagaga tttcacttta 1141441 ttgagtgttt gataatcagc gaactgaaca gcgatatctt cttttccttg gatagcacga 1141501 atccaactat attccacatc aataatatga aaaagggtat ataaaatatt ctctactccg 1141561 ccaagacgat ttttaagtaa ttcttcagtg gttagttgat gacaccaagt aaaccattga 1141621 tctctaacct gccagttata ttcaaaaaat ttcatcacta aactcactcc aatactatca 1141681 tgtatcataa caattagccc ttttttccgt gattcctcta ttaatgaagt gatgattgag 1141741 aaatgtttac attctacctg ttgtatggca ttaaaaataa taatgcatat ctcgtcgatg 1141801 atgctgtgcg tcttgttact tttacaaagt aagaatcggc attttcttca tatacaatta 1141861 ggaaaaaaca tactagactt gaagaagcag tgatacatag gagtgagaaa atgaaagaga 1141921 taaaagaagc ttaccagcaa tgcggacaga ttgttggcga atacgcgcca gcctgtttca 1141981 aagcattatc atatctcccg ctaaagcaaa gacaagcctc ttgggcagta ttgtcgtttt 1142041 gccacacggc ggccagtgca gacgaaaagg tattgcccgc atttgaagct aaagctgatc 1142101 atgtttacca aaggacaaat aacggtaaac aacatctatg gaaggctttt gatcatgcgt 1142161 atcggacctt tacattggaa agcgaacctt ttcgggagtt tattgccgca caaaaagaag 1142221 acgccaagcc gtatgatgac cttgatgaac tgctcatgta cgcatatcgg acgggcggtg 1142281 ctgccggatt gatgctgctg ccgatactga cacgccgaaa acaagatcag ctcaaacaag 1142341 cagccgtctc tctcggcttg gccatacagc tggttcgctt cttaagtgat cttggcacag 1142401 atcagcaaaa aaaccgcatt ccccgtcagg taatgcagca attcggctat acagaggctg 1142461 atctccaaaa aggcaccgta aataaagcgt tcacaatgac gtgggagtat atcgcttttg 1142521 aagcagaagc ctaccttgaa gagtgtcagg atgccttgcc gctatttccg cagtattctc 1142581 aaaaaacggt gaaagccgct cttcatttgc accgggctgt tttagaaaaa atccgggcga 1142641 agcagcacga tgtatttcaa tatcacttcg ctctcacaga gaccgaagtg aagcagattc 1142701 tgtctgatat ctaaaaaaca cccggccttg attgagccgg gtgttacgcc ataccttttt 1142761 gaatccagat acgtgagcgc catcttctgt acattaagat tccccggacc cattcatccg 1142821 cgataaaaga aatccaaatg ccggcaagac cgaaaccgag gtggatgccg aaaagataag 1142881 caagcgggag gccaatgccc cacattgaaa tcattgccat gtaaaccggg aatttcgcat 1142941 cccccgcggc ccgcagagag ttaatgataa tgacattaaa cgagcggcct ggttcaagga 1143001 taatggtcat ggcaatcaat aggcttgcag ttgctataat gtcagggctt tgtgtgaaga 1143061 gtccgatcag gtcttttgaa aagatcgtca tcaaaacaga ggtagccgca gcaattccga 1143121 gtgcccaata taagctcttc atgcagcgct cataagcggc atcaaattgt ttgccgccga 1143181 tataacggcc gattaagatt tgtgtaccct ggctgatcgc agtgccgaac agcaaaataa 1143241 acatcgtaat attttgcgta tacacttttg ttgtcaacgc ctgcgcgccc atgatggcga 1143301 taaaatacgt gactatcatt tgcgacaggt tgtatgaaag ctgctctccc gcagaaggaa 1143361 tgccgatttt cagcagcttg cgcaaatgct ctttatgcat atgaaagact tttttcagcg 1143421 acatcttcag ctggatgcgt ttgttgacaa tcacaatcat cgcgattaat ccgatgacgc 1143481 gggcgataga tgtggacatg gccacaccgg caacaccgag aacaggaaag ccgaacaaac 1143541 cgaaaatcac aacaaagttt ccggcaatgt ttaaaatgtt catgccgata gtgacaaaca 1143601 ttgtatcttt tgtgtagccg tagcttttta agatcgcgct gaatgtcatg attaaagcct 1143661 gaataaagga cagacctccg acaacttgta aaaagacttt cgcatcaggc atcagtgcgt 1143721 ctgataatcc catcatatga agcagaggga cagccgcgaa aaagacgacg gcgctgatgg 1143781 ccaggctgat gaagaagttg gcgccgattg acacataagc gacttccatg gcttctttct 1143841 tttgccgtga gcctagaaat tgtgaaatga taacggtcgt tcctgttgcg ataaagctga 1143901 acatcacgat aattaaattt aaaatctggt tgctgacgcc gactgctgcc acgctgttat 1143961 ccgagtattg gctgagcatc agtgtatcgg cattacccat aaacatatat aatgagacct 1144021 caataaagat cggccaagta agcgaaaata atgagaacgt tttgtcagcg ggttttttca 1144081 aagcagttga tttgaagaca gcttgtttca tcgtgtctaa cccctttcgt aaataaaatc 1144141 aacgttttaa agtgtacctc catttcctta taataaaaag ggatagaaac gatacttctt 1144201 gtaaaaatcc gacttaaaaa ggaggatgat tcaaatgcct cgcatcctgt ttacagtccc 1144261 gccttttccg gtatttatcg cagctgggga aggggttttt aaaaaaggag aaacccatgt 1144321 gaaacgtgta ttctccgtgt ttgatctgat atatgtcaaa cagggaacgt tatatataac 1144381 ggaaaatgaa acatcgtttt ctgttgaagg cggcgagtac atcttgcttt ctcccggtct 1144441 tgaacactac gggacgaagg gcagtgatga agcaacctcc tactattggc ttcacttcga 1144501 tgaacatcga tatgaattta cggcaaaggg aggcagcaac tggtctgagc ttcagcagga 1144561 aaaagggagc ttcgaagagc tggcccgcta cggattggcc ttgccgagaa aaggcaaggt 1144621 gcagcgcccg cagtttatgg cgcagcagtt tgaaaagctg atcgattact ccgcggaaaa 1144681 ctctgatttg ccgctcagaa agcaaatttt atttgaggag ctgatgctgc atcttcaaaa 1144741 agaagcgttc caaataccgt ctgcgaaaga gcgggtagcc tgggaggcgg cccggtattt 1144801 acaggagcac tataaggaaa agacgacaat caaggatctg tcgctcgccc ttcactatca 1144861 tcaggattat gtgagccgct gcatgcagca ggtgctcggc gtaactccgg cacaatacac 1144921 gaaccgggtg agaatgacgg aagcgaagcg tcttttatcc tctacaaatg ataaaatggg 1144981 cgttattgcg gaaacggtcg gaatggaaga tccgacatac ttttcaaaac tctttaagca 1145041 gatagaaggc atttcaccaa ttgaataccg gaaaattgtc agccggaaag ttcaataacc 1145101 agacgaggga tgaacatgaa aacaacaatt tacgatgtgg caaaggcggc gggtgtttcg 1145161 atcacaactg tgtcccgtgt gataaacaat acggggagaa tcagcgataa aacacggcag 1145221 aaggtcatga atgtcatgaa tgaaatggca tacacgccca atgtccacgc cgcggcgtta 1145281 acgggaaaac gaacgaatat gatcgctctc gtggcgcctg atatttcaaa tccgttttac 1145341 ggcgaactgg ccaaaagcat tgaggaaaga gcggatgagc tcggttttca aatgttgatt 1145401 tgcagcaccg attacgatcc gaaaaaagaa acaaagtatt tttctgtgct gaaacagaaa 1145461 aaggtggatg gcattatttt tgcaacaggg attgaaagcc atgacagtat gtctgctttg 1145521 gaggaaatcg ccagtgaaca aattccgatt gccatgattt ctcaggataa gccgcttctt 1145581 ccgatggata ttgttgtgat agacgacgtt cgtggcggat atgaggctgc caagcatctt 1145641 ctgtcactcg gccacacgaa catcgcctgc attatcggag acgggtcaac gacaggcgaa 1145701 aaaaatagaa tcaaaggctt ccgtcaggcg atggaggaag cgggcgtgcc cattgatgaa 1145761 tcacttatca tccagacgcg gttttccttg gaaagcggca aggaagaagc gggaaaattg 1145821 ctcgacagaa atgctccgac tgctattttt gccttcaacg acgtattggc ttgtgccgcc 1145881 atacaagctg cgagaataag aggcataaaa gtgccggatg atctttctat cattggtttt 1145941 gataatacga tactcgcaga aatggcggct ccgcccctga caaccgtagc ccagccgata 1146001 aaagagatgg ggcggagcgt catcgaactg ctggcagaag caatagaggg aaaacgaaag 1146061 gcgaaacaaa aaatagtgct cccgcctgag cttgtagtca gacattctac atcaccgctc 1146121 aacacatgag cccgctaatg agcgggtttt ttcattatga cagttgaagc caaaaaaaca 1146181 tattgcgtgt aaaccaaagg cggtgtaaaa tataaccatc ttttgagaaa gcgcttgcgc 1146241 aaaatggcag agcggataga accgctgttt ttttagctgt taagagaaaa cgctttctca 1146301 aagcgagccc gaaatgagat aaaggagagg atgggacgtg gaacatcaag taagatgtgc 1146361 agtattggga ttaggaaggc tcggttatta tcatgcgaaa aatctcgtca ccagtgtgcc 1146421 gggggcaaag ctggtttgtg tcggtgatcc gttaaaaggg agagcggagc aggttgccag 1146481 agaactcggt atcgaaaaat ggtcagagga cccgtatgaa gtgttagaag atcccggcat 1146541 tgatgctgtc attatcgtaa cgccgacaag cacacatggt gatatgatca tcaaagcagc 1146601 cgagaacggc aaacagatct ttgttgaaaa accgctgaca ttaagccttg aggaatcaaa 1146661 agcagcttct gaaaaagtta aggagacagg tgtcatctgc caagtcggct ttatgagacg 1146721 gttcgatccc gcatacgcag atgccaaacg gcggatcgac gctggagaaa tcggcaaacc 1146781 tatctattat aaaggcttta cgcgcgacca aggcgcgcct cccgcagaat ttatcaaaca 1146841 cagcggtgga atttttatcg actgttccat ccatgactat gatattgccc gttatttgct 1146901 aggggcggaa atcacttctg tttcaggaca cggcaggatt ctgaacaatc cgtttatgga 1146961 gcagtatggc gatgtggatc aggcgctgac gtatattgaa tttgactcgg gcgcagcggg 1147021 ggacgtcgag gcaagcagaa cctctccata cggacatgac atccgggcgg aggtgatcgg 1147081 gacagagggc agtattttca tagggacatt gagacatcaa catgtgacca tcctatcggc 1147141 taaagggagc agttttgata tcattccaga ctttcaaact cgttttcatg aagcctactg 1147201 cttggagctt cagcatttcg ccgagtgtgt ccggaatgga aaaacaccga ttgtgactga 1147261 tattgatgcg acgatcaatt tagaagtggg tatcgccgca accaattcct ttcgaaacgg 1147321 catgccggta cagctagatg tgaagcgcgc ttatacaggt atgtaaaagc taagtatgtt 1147381 gcatttgagg ctttccgcaa aaaaagcaag ggcattttag cccttgcttt ctcttttctc 1147441 atataaatag tacatataat cagtaggtac gcctgaatgg tccagctgtc tcagcatggc 1147501 ggttacgttc cctctgtggt aagtgccgtg attgacgaca tgcaggatgg tgtctgcata 1147561 ggttgattcc agtgtaccta gtttcggatg ctgcattgtg aaggtctgtt ctaagtccgt 1147621 ctggcggctg aagaaatcat gatactgtga ctccagctcg gcagcgtgct gtttaatcgc 1147681 tgccatatta ccttgcgcgg actgtaattt gcctgcgctg tctataatct cttggtaggc 1147741 cactcccgaa agaacattca gccaaatgta gtcagccctg cacatatgaa gcagcacgtc 1147801 gctgacagaa ggaaatacgc tctttacttc ttgataggca gtttcctccg gcaggttttc 1147861 gatatgggta aatattttct tgtttgccca agaatgatag tcataaaact gttttgcatc 1147921 agtcatcagc atgccccctt ttctaagaaa ttcgtttttt tcatctgttt ctccttcaat 1147981 tgcaaaagag tgacacccca aaatatcctg ccgctgccca cattaccgct gcagagcatt 1148041 tgtttacgat cagcataagc ctgccgctcg tatctatcgt ctgaaacaac cggcccgcta 1148101 ttgcaaggct gatgaaccaa atccaagaca cagcgatgca ggcggccata aagagccatt 1148161 tctcaagccc cgaatattga agagagctcg tgccgatgac gccgatcgtg tccagaatgg 1148221 catgcgggtt taaaagagaa acagcggccg caaacgcagc ttgctttttt ggtgtgaacg 1148281 tatgtttctc attttggctt gtgttcggac ggatgttcca agtcacccag cccatataaa 1148341 gcaaaaataa aaatccgccg gccatcatga ctgtctcaaa cacaggcagc tcctgcacaa 1148401 tgacagacac gcccgcaacg gctaatacaa ttaacaaggt atcgcagact gaagcactga 1148461 tgacagctgg gagagcccgc caaatatgct tttgcaacgc gccttgctga aaaataaaca 1148521 cattctgcac tcccagcggc aaaattaagc caaacgcgag cacaattccg tgaatgattg 1148581 cattcatgct gaaaaagctc ctttcacatt ttttttcaat cataagagag attgtcacta 1148641 aagtctccag ccatttggtt gggttaggaa ccagccaaat gtataatgtg taaaaaaggg 1148701 gggcatgacc ttgtcgcaat ggcagccaag ccgaaagtcg gatgttccgc tgcatcggca 1148761 gatcgaacaa tatatgaaag acaagattct tcacggagag tgggctgtag ggacgaaaat 1148821 cccctcacag agaacgctgg ccgacatgtt tcaagtcaac cgcagcacag tcacagcagc 1148881 catagatgaa ctcacgtctc aaggcttgtt agagggaaga aaaggcggcg gtacgaaggt 1148941 tgtaaacagt acttggagcg tgctgacggc tgagcctccg cttgattgga gcgattacgt 1149001 ccgttcgggc attcatcgcg ccaattcttc catcattcaa gctattaatc agaacgaacc 1149061 aagagcggat atcatcagat taggaactgg agaactttca ccggatcttg tgcctgctga 1149121 cacaattgga cggatgtttc agcaaatcaa tccgggcgtc ctgtctttag gatatgagca 1149181 gccgaaagga aaccgtcagc tgcgggaggc agtggccgac catttaaaag gaaagaagat 1149241 ccatgtgtca ccgtctgcaa ttttaattgt gtccggtgca cttcaggcac ttcagctcat 1149301 ctcaattgga cttttaaaac gagattctgt cattttgacg gagaagccgt cctaccttca 1149361 atccttgcat gtatttcaat cagctgggat gcggcttcgc ggcttgccga tggatgatga 1149421 aggggtcaaa gcggggcttg tttcttctaa tcgaaaacaa tatggaggac agctgcttta 1149481 cacgattccg tcgtttcata atccgacagg cacagtcatg tcagagcagc gaaggaaaga 1149541 gatcatcagc ctgtcaaaaa aagagcagat gcccatcatt gaggatgatg cgtacggtga 1149601 tttatggttt gaagaaaaac cgccgcagcc gttgaaagca atggatcatg agggcaatat 1149661 tctgtatctg ggcgcgtttt caaaaacggt tagccccggt ctgcgaatcg gctggcttgc 1149721 cggtccggag ccggttattg aaaggctggc ggacattaaa atgcagacag actacggatc 1149781 aagcggcctg tcccagtggg cggctgccga gtggctgtca cagggatatt atgaagagca 1149841 tctgacttgg gtacgcagga agcttaaaga aaggagagac gccgccgttc attttctcga 1149901 gcggtatgcc ggggacattg ccacgtggcg gattcccgca ggcggctttt atatttgggt 1149961 gacatttcac aaaaacctgc ctgtcagccg tttcttttat gaattgctga aacggcaggt 1150021 gcttgtgaat cccggctata tttatgacgg tgaagaccga aacagcatca ggctgtcata 1150081 ttcctatgca tctcttggag atttggaaac tggcattaaa gcggcagctg aaacagcacg 1150141 ccgcctgatg atgtcctagg ctttggttat acgatgacag ctcccagtgc cctggcgaag 1150201 gcaatcgcgt gctcaggtgc gattttgcag cctttcaatt tgtcgaggga gacatgaagc 1150261 tgttcaaaac ggcacgtgct gatgtccatg ttttgaaggg acgtgccggt aaagctggcg 1150321 ccttccaatt cgcatccgtc aaagtgtgtc tgctggagca ccgtatcgct gcattcactt 1150381 tgcataagag cacagtgatc aaatcgaact tgtttcatat ttgagtacga aaatgagctg 1150441 aaatgtccgt ggcattcctc gaatgaaaca ttccgcagcg ttgcttccgc cacattcatt 1150501 ccaaccattt ttgactgctt aactgaagtt ctgtgaatga cagccccgct gaaatcggcg 1150561 tttgataaat cgcatttttc aaagatcaca tcggtcagtt caatatgccg aaaagacaca 1150621 tcgataaaga cgacatttct gaataccgtt ttttcaacac atagtctttc gatatcttcg 1150681 ccgcagatgg tgcaatcttc aaacaaatgc atgctgatta catcatcctg tgtcacggca 1150741 tcatgaaaat ctgcggtttg caggttttcc ggtatgttcg gtttttgaat tgcgatttta 1150801 ttcatgtgat gacatccttt gctgcccgaa aaacagaggc ttccgggttc aatttaatag 1150861 atcgttaagg aaattgatac atatagtaaa tcgtgaagag ccttttcttg gtacagcagc 1150921 ccgcttgttt tgtaagcata aatggaaagc ttcctatacg tcaaggcgtt tacaggccga 1150981 aaaagccaaa gggaacagga ggaatgcgga atggggcatt acatcaaaac cgaggagcat 1151041 gtgacactgt ttgtagagga tatcggacat ggaaggccga tcatcttttt gcacgggtgg 1151101 ccgttgaatc ataagatgtt tgaatatcaa atgaatgagc ttccgaaaag gggatttcgt 1151161 tttatcggcg ttgatttgcg gggatatggg caatctgacc gcccttggga aggctacgat 1151221 tatgacacga tggccgatga tgtgaaagca gtcatttata cgctgcagct tgagaatgcg 1151281 attcttgccg gtttttcaat gggcggcgca attgcaatcc gttatatggc aaggcatgaa 1151341 ggagccgatg ttgataagct gattttactg tctgcggcgg cccccgcgtt tacaaaacgc 1151401 ccgggttatc cgtacgggat gaggaagcag gatattgacg atatgattga attgttcaaa 1151461 gctgatcggc ccaaaacact ggctgattta gggaaacagt tttttgagaa aaaagtgtct 1151521 ccagagctta ggcagtggtt tctcaatctg atgctggagg cttcctccta cgggacgatc 1151581 cactcgggca tcgcattaag agacgaagat ctcagaaagg aacttgctgc aatcaaggtg 1151641 ccgacgctga tcctgcacgg gagaaaggat agaattgcgc cgtttgattt tgcgaaagaa 1151701 ttgaagcgcg gcatcaaaca gtcggaattg gttccgtttg caaacagcgg gcacggagca 1151761 ttttatgagg aaaaagagaa gatcaacagt ttgattgcgc agttctccaa ctcataagaa 1151821 aaaacccgac attgatcggg ttttttatat aattcctctg ttttgcagtg cgttaatgat 1151881 gagatcagct ccatcggaaa tagaggtctg gtcagactca atgatgaaat cgggtgaaag 1151941 cggcgcttca tacggagaat cgatcccggt gaaatgtttg atctctccgt ttcgcgcttt 1152001 tttataaagc ccttttggat cgcgctgttc acaaacatgc agcgggcact tcacataaat 1152061 ttcgaagaac tcacctttag gaaagagcgc tctaaccatg tcccgatcct ctctgaatgg 1152121 agaaataaaa gccgttaaaa tcatttgccc gctgtcgaca aacagcttcg ccacttctcc 1152181 gatccggcgg atgttttcaa tcctgtcacc agtctgaaat ccaagatctt tgtttaagcc 1152241 gtggcggata ttatcaccgt caagcacgta gctctgaatg cccttgcggt aaagcttttc 1152301 atcgacagca ttggccagca ccgattttcc ggagccggac aaacctgtaa accaaaggac 1152361 gcagcttttg tgtccgttta aggactgtct gtcagacttt gagatggcag cgggatgcca 1152421 aatgatgttc ggattgtgtg tcattgcaat tccccgctgt tttgcttgat ggcaacaggc 1152481 tgttggtgaa gtcccttgat cagcacggct gcgacctcag gccggctgaa ttctttaggc 1152541 ggctttttgc cttggcggag aagctctctc acttttgtgc ctgataagtg gatgtggtct 1152601 ctcgggctgt gcggacatgt tttggaggtg cccatgtttc cgcattttcg gcaataaaag 1152661 ctgtgctcaa aaaacagcgg cttgatgccc agctcttcct ctgtgaatga ttgaaaaata 1152721 ttttgggcgt cgtatgttcc atagtagctg ccgacacccg cgtgatcacg gcctacaata 1152781 aaatgggtac agccgtaatt ttttcggacg agcgcatgga aaatcgcttc ccgcggacct 1152841 gcataacgca tggcggcagg gaaaaccgat aacatgacac gatcctttgg ataatagtga 1152901 ttaagcaaag cctggtagct ctccattctg atatcgctgg ggatatcgtc tgactttgtt 1152961 tctccgacaa gtgggtgaag cagcagaccg tcgaccgttt ctaacgctgt tttttgaatg 1153021 tattcatgcg ctctgtgaac agggttcctg gtttgaaagc cgacaatcgt cttccagccg 1153081 agtttttgaa aggccgctct tgtttcagcg ggcgttgcat aaaactgttc gaaagatttg 1153141 tcaggcaggc tgctgaccgt gataggccct ccgatatagt aatccgggcg cgccagcaat 1153201 ttttttacgc ctgggtgggc aggatcgttt gttttaaaaa cagacagtgc ttcttgtgtt 1153261 ttatcaggct ggtatatatc ggtgactgtg atcatgccgt aggtaacacc gtctttcaca 1153321 agcttgacgt gatctccggc agacagctgt cttgctgttt tttctccgac aggcagcgta 1153381 atcggcaggc tccacggcaa gccgtttgcc agcctcatct ctttcacaac ggaatgataa 1153441 tctttttctc ccaaaaaacc tgttaacggg ctgtagccgc cgatcgcaat aagctccaga 1153501 tcactcagtg caagctgatc cagctctgct tggcacgcgc acccttcaaa atggcatgcg 1153561 ggatcacagc ggttgattaa tacccctccg tggggttcgt ttccattcaa cgtgttcaac 1153621 ctccatttat acgtttcctt gttttctttt ctgcacttaa tgaaagtttg acatcagcgc 1153681 cttaacatca tttcgattct cacatcaaga acctgccatc cgctattctt gatgcaggcc 1153741 gcattctgtt ttctcccgtc cggcccatct tccagccctc tcatcgttcg ggtccgggga 1153801 aggcagtgta cacatttcac agcctatgct cggataatgt tgatcgtgca gtttgttata 1153861 aggcaaattg tgcaggcgga tgtacgtcca aacgtcatcc catgtccagt ggataagcgg 1153921 gcaaattttg atgagctcaa acttctggtc caggtttacg tattgaatat gctttctcgt 1153981 tggtgactga tcccggcgca gtcctgaaat ccaagctgtc atgccggaca ggtgcttttt 1154041 gagcggttcg attttccgca attggcagca gaggttcggg ttatgcttcc acagctctcc 1154101 gccgtacttc gtcccctgtt ctgttaagct cagctcgggt tcgagcatct ggattgcaaa 1154161 tcccggatat cgttctttga cggtctcgat cagctcatat gtttcctgaa aatgaagccc 1154221 ggtatccaaa aagatgatgt gtgcgttttt gttgattttt gatattaagt cgagaagcac 1154281 cattccttct gcgccaaagc tgcaggcgta cacaatcttt tctccgtacg ttcggtaagc 1154341 ccatttcaac acatcgagct catcgatcaa ttgatccgtt atctgtttgg acagcatgtc 1154401 gttccaagtg tcatatgtga tggtttcgtt caatgttttc cccccgtttg catctgcttt 1154461 ttttatctat tgatcgagtt ataggcagac tattcatttt ttgcataaag gttcaggttt 1154521 taggtgccgc gcccgcctaa aatgaggtgc ggaaccatta agagcccggc tgaatatgct 1154581 ttttagcaaa atggttttat gcccaaggag aggtagtatg ccgattgcca tttatcaggg 1154641 gcatcatcat tcgcttgccc cggcggacat taacatcgtc attgatgtca tcagagcctt 1154701 tacggtcgcc cattatgcgt ttatcggcgg ggcgaaagag attttgttgg tccggacagc 1154761 tgatgaagcc tttgcgctga aagacaccta tccggattat gttttgacgg gagaggaaaa 1154821 gggggtcggt atcagcggat ttgatttaga taattctcca aaacgtatgg ctgggcagaa 1154881 tatgacggat aaaagcctga tccagaaaac aacaaacggc gtcacagcag cattgggggc 1154941 gctgaacgca aagcatctgt tcgtaactgg attttccaat gccaaaacaa cggcacagca 1155001 tgtgaaaaag ctcgtcgcaa acgattgtgt cataaacata gtggcttccc atccatccgg 1155061 tgatgacgat atggcatgtg cggagtatat caaaggcatc attgaaggga caaatgtggt 1155121 aacggctgcg gaggcgattg aaagaataaa aggctcttct gttgcggaga agttttttga 1155181 ctgccgccag ccattgtttg attcggaaga catcgtttac tgtacaaaag aactgacggg 1155241 cgatttcgtg atgaaagtga aacaagatgg agaagttcca acgatagaga gggtcataat 1155301 atgaatgatt tttcactaga attgccagtg agaacaaaca agccgagaga aaccgggcag 1155361 tccattttaa ttgataacgg ctatcccttg caatttttca aagatgcgat agccggagcg 1155421 tccgactata ttgattttgt gaaattcggc tggggcacat cattacttac gaaagatctt 1155481 gaagaaaaaa tcagcacact gaaagaacat gacattacat ttttctttgg cggcacactg 1155541 tttgaaaagt acgtaagcca gaaaaaagtg aatgaatttc atcggtactg cacctatttc 1155601 ggctgtgaat atattgagat ttcaaacggt acgctcccga tgacaaataa agagaaagcg 1155661 gcttacattg ccgatttttc tgatgaattt cttgtgctca gtgaggtggg cagcaaggat 1155721 gcggaattag caagccggca aagctctgag gaatggcttg aatatatcgt tgaggatatg 1155781 gaagcgggcg cggaaaaagt gattacagaa gccagagaaa gcggaacggg agggatctgt 1155841 tccagcagcg gcgatgtcag gtttcaaatt gttgacgaca tcatttcctc ggatattgat 1155901 atcaacaggc tgatttttga agcgcctaac aaaacgcttc agcaagggtt tattcaaaaa 1155961 atcgggccga atgtgaatct tgccaatatt ccatttcatg atgccatcgc gttggaaacg 1156021 ctgcgtttag ggctaagatc cgataccttt tttctgtaaa atagcggctg cggggctctc 1156081 gtcgtgaaga gagcctctgc ctattatttt ttatggcggt acataggcgt gagataggga 1156141 agtgaggtca ggcggatgtt gtagatgaag tcgatgactc ttgtcgatat cacctggcat 1156201 atgagggctt gaatgacgat gccccagtca ataatagacg cggtgaccat aaaaatgatg 1156261 caattcatga tgagcaggat cgttccagga ttcccgccgc ggtagataga aatcatcaga 1156321 gcaagggctc cgaatcctcc gttcgaaatt ttatatttgt ataaaagtcc gattccgagt 1156381 cccaataaca ctgcgccgct tgccagatca agccacaggt tagatgtgat atcaggaaaa 1156441 actgcatcaa agatcaatac cgagacagag gtgacggtga tagaagcgag ggtgccggtg 1156501 aatgttctca tctccagcca ttttaaagcg gtaaaaagca ttgatacatt cacagcccac 1156561 actgaaaatc cgtgggggat ttgaaacaga taatgcaata gcaccgcaat acctgctgca 1156621 ccgcctgtcg gaatatcatg cggaaataaa aacaaggaca tgccgagtcc ttgtagtacg 1156681 ccgcctacga caatcataaa cgtaagtttt gctttcatca gcagttcagc cattaagtca 1156741 tttgctcctt tatgaaaaga cttgtccgct gttttcattt tatgaggctg tccattattt 1156801 atgtctcaaa ataaagaaat ggcccagctt aataggctga gccatcccac ttgtagcgat 1156861 tgacgatctc catattgatc tctgtgccaa tgccttttcc tttcgggatg tggaccattc 1156921 cttttgaagg ctgcaggctg acgagatctg taaaaggatt ctccatgacg tcccactcga 1156981 tcggttcaat gtgatcgttc ttcattttag accatggggg cagacaggct tgtgcaaata 1157041 aagcatagag ccgtgagagc gatccgtcat atgcatgggc ggatgctctg acgccgaaat 1157101 aacgcgcgag ctggaggcag tcccgaaact catcaattcc gttgacatgc atgacatcgg 1157161 gctgaatgat atccaaacag cgctgtgaaa ggagaggcac atattgcgcc gggcctttca 1157221 tgttttctcc gccggcaaca ggaacagaca aacggcttcg aagcatagcg taatcctgcg 1157281 gctgatcaaa gggcaaaggc tcctcaagcc agccaatgtt cgtccattcg gagaaatagc 1157341 gctcccattt aaaagccgca gcggcatcgt agctttggtt tgcgtccaga atcatcgtaa 1157401 tggagctgcc tgctgtatgc tgcagcgcat tgatgtgccg gacatcctcc ttgaatgaag 1157461 tcccgccaat tttgactttg atttgctcaa aacctttttt caactgggct tcaacattgg 1157521 agactgagcg gctgatccat tgcggggagt ctgagtacga ttgaaaagac gcgtacacag 1157581 gaatctcctc tctgtatcgc ccgccccata attcgcaaac cgaacaatcc gcagctttgg 1157641 ctgcaatctc tgtcagcgcc atgcttacag cggaggccgc ccgctggtgc catttttgaa 1157701 tcgtgcgcac taatgacagg cggctgccag cctgttttcc taatagaaat gggatgatcc 1157761 gcttcgtaaa accgacatgg agagcaggga gccaatcaac gcattctccc cagccgtcta 1157821 tcccgctttc ggtgataatc ctgatgagat aacaagtccg atatcgttta aacccattgg 1157881 catctccgta tggcttttct aatcgatgaa atagcggaaa ggtttcaatc cgtacaattt 1157941 tcacactggg tgctaccttt cctcagcggg ctggagccga ttgccagcca ttttagggtc 1158001 ttctttttct tttgtttctt cattgttttg cttcacatgg atgagcatca tcacaagaat 1158061 cccgacaacg agagtcaatc ccgcgatgct taaaaacatg ccgggtctgg accattgcat 1158121 caggcggccg aaaatcggag gaccgatcgc tacccctaag aaacgtacag agccgtacag 1158181 cgaggtgaca aatccccgtc tttctttgcc gacagccccg gtaatgaaac tgttcacaca 1158241 aggaaggaca agacctgagc ctatactgct cagtacaaga acactgataa aaaggacaag 1158301 attttcaatg aatgacagtg ccgcgtagga tacggtcatg aacgccaatc caagtacgat 1158361 cagctttttc attaacgatt gcttttgccc gattttgctt cctgttgtat aggacgtcac 1158421 acacataacc aaaagcggga tcgctaaaat taagcctttt ttcacgccgt cggtgtcgta 1158481 tgttttttca agaacatctg agagataaaa caggatgccg aataaagtaa acaaacaggt 1158541 cgcaccggct aaataagcgg taaacagcca tctgccttca tgtttaaaga cacttaacag 1158601 cccttttgca tattgtccga ttggtggcgg ttctttttcc tttttctttt ctttaataaa 1158661 aatccaagtc agtacgatcg aaatgataca aaacacagga aaggcaaaaa acgcgccata 1158721 ccagacaagc agggcgatca gcgagccaat gatcggcgat agcactttcc ccatgccgtt 1158781 tgaagcttca acaaggccga gcaccttgct ctcctgggcg cctttaaaca gatctcccgt 1158841 cagtgccatg gcaattgggc cggttccggc tgccccgatt ccctgtaacg ctcgtcctgc 1158901 catgacccaa ggataggcat tgtcaaaaaa acctgccgca aacccggcta acaaaccgcc 1158961 ggcaccatac aaaattaagc agggaataat gatgactttc cttgagaatc ggtctgcgag 1159021 ataaccgaca atcggaatcg caaatgctgc aatcaaggaa aatactgtga tcacgagact 1159081 gacttgaaat tgtgataaat gaagttcaga tttcattttt ggcaaaatcg gaataagcat 1159141 cgagtttcct agggttaata ttaaagggat tgaaccgatt gccacaatcg tcattccgtt 1159201 attttgtttt gatgattcca tctcagagca cactcctttt cttctgctta gaatgtccct 1159261 gatggcttcg tttattcagc gatcagacag caaaaaaccg aacagaagat acctgttcgg 1159321 gaaaaaagag ggttaaccga gagcctgtga aatcaaagca tataagtgtc cattttgaat 1159381 aggcgctttt ttctgataga acaaaatcgg aggttcatca tctttatgaa atcccatttc 1159441 tatcaggctg tcatgcagag acgtgtgttc actcggtata tcgattcgca tcggcccttg 1159501 tttgccggcc gccagccttg taattatctg tgctgcaaca tctgatgatg gagcgatgat 1159561 agggccgaat ttcaaattgg ccggtgtctg tacagaaagt ccgtagccaa tgagctgtcc 1159621 gtcctgattt ctggcgatga tacattcgca tgaagcagaa ataagctgct gcaaaaggtt 1159681 tgatcgatct ccgccaaagg cagccagatc cgccgcggtt aagtcgtgaa agtcttgttc 1159741 tctaaaggat gtcagttcag catcaagctt ttttgtataa ggttgaaaac tgtgacagct 1159801 gtactttcgc actgaacctg ccgtatgaaa acctgctttt tcataaagcg gcaaaccttc 1159861 ttttgtggcg caaagcctga tggcggtgtt ttcatccgtt tgggtaatac aggcgtttac 1159921 catacgccgg ccaagaccga gccgttgata ttccttgtca acgataacaa ggccgataga 1159981 agtaagacgg ccaaacaaaa acaagccgat gcaggaaata atatcaccgc tgacattttg 1160041 ataaccgaaa aagcgtccct gctgaacaag cagtttcagc tcttgttcgc cataatccgg 1160101 ccacccggct tgcccgcaaa gccgcaataa gccggaaacg tgttcttcat gaagcttaat 1160161 cagttcatct actacgtcca taagatcacc tgcttgttct aagtgttttg tacatgacaa 1160221 tatgattgcc aatgccggga atgtcaaatg gttcgccaag ttccttccag ccaagcttgg 1160281 catagtagcc cttgacatgg tgtcttgcgt tgcaccatac cgcctgaacg ccgctctccg 1160341 ccagtttgtg ctccgcgtgt ttgatcagcg tgcttccagc tttttgatcg cgatatccct 1160401 cgagcgttgc catgcctctc agccgatacg cagaggcttc cgttaataaa ggctgacttt 1160461 gcggggaaaa agaagcgatg ctgatcagcg ttccatcata aaacacgccg agatgaaagg 1160521 agccttctgc gtgatcctct ttatatttgc attgttcgat ggattgatgg ggacgcagaa 1160581 tgcgatgccg gatttcatat gtatcttcca cggaaatggt tttgacttcg agcataatgt 1160641 tcctcctcat gattgttttt ctatatcgta acacgaatct cgttgaaaaa gactgcccga 1160701 ttcgatcagg cagtcttttg gaaattaatg caaaaagata ttttggcgct gctcatcttt 1160761 ttgctgaata tatgatgtga gctcagcggt taagtcagat ctgaggaaag gcgttatcaa 1160821 gtagatgccg ttaaacagct cgcatgccgt atccagcagg gagcgtgcaa ttgcaaggcc 1160881 ttccgccttt tgcttttctt tatcttcacc ggcatgggcc attttttcgc gaatcgtatc 1160941 agacagctta atgccgggaa tttcattatg gatgaattcg gcattccggc tgcttgtcag 1161001 cggcatgatg ccgatataga tcggcgtctt cagatgtttt gtttcgttat ggatatcgac 1161061 aagctgctgc tcggaataga caggctgaga aacaaaataa tctgcgccgc aatctatttt 1161121 tttctcaagc cgttttaccg ctttatccag atggcggacg ttaggattaa atgcggcggc 1161181 aactgagaaa ttcgttttct tgccgagcgg ttttccagac agagacagac cttcattgaa 1161241 ttgtttgatc agcctgatta aatcaaaaga tgttaaatca tatacagacg tcgccccagg 1161301 aaaatccccg attttagaag ggtcacctgt aatagcaagc acgtcattca gccctaacgt 1161361 atcaaggccc attaaatgtg actgtaagcc gataatgtta cggtcacggc acgtaatatg 1161421 gacaagggaa cgcatatcga gctgctgctt gacaagggcg ccgcaggcaa cattgctgat 1161481 ccgcggggtc gccaaagaat tgtcggcgag tgtcagggca tcgattcccg cttcttttaa 1161541 ttcagcagca gcggacagaa atttgtcaaa gcttagtttt ttcggcgggt ccagctctac 1161601 gataatagag cgttttttcg ctgcgatctc atccaggccg ggctcggttc gctcgtgatg 1161661 aacagaaatg aattctttcg cccgggtttt gacttctttt tccgtaatcg gagccagccc 1161721 gccaaccgct tccgccatcg ccctgatgtg attcggcgtt gtgccgcagc agccgccgat 1161781 aatccgcgca ccttgcttac ggaattctga cgcgctgttt tgaaaatacg tgtcgtctgt 1161841 ttcatagacg agccgtccct cttcaagcga aggaagactg ctgttcggat aaacggataa 1161901 gaatacgtca tcaaaaatcg gcacttcgct tagcgcttca atcatgtgat aagggccgag 1161961 gcggcagtta atgccgacaa tatcagctcc gagatccgca atcgagcgca atgcgtcaga 1162021 aagcggcgtt ccgtcctgca atacgccttg ctcgtgcatg gagacattga gcataatcgg 1162081 aagatcagtc tctttgcgcg cgattttcag cacttcacgg gcttcttcca aatcataata 1162141 tgtttctaac agcaagccat ccggctcttc atgcagcagc agatacagct gctcgcggaa 1162201 gctgcgctta atttcgtcaa gactgtatgc gtttttatta aatgtgcgta tgccgcccat 1162261 cgttccaagc acgtatgcat cgcctgctga agcccgcgcg atctttacgg cctcctgatt 1162321 catttttttg atgtcatcct caagcccgtg tctggataat ttaatatagt tggctccgta 1162381 cgtattcgtt tgaataatgt tggctcccgc ttcaacgtac gctttatgta tgcgctgaat 1162441 ttcctccggc tttgaaatat tgagctcctc aaaacacctg tcaatgccat aggagtagag 1162501 gagcgtcccc atggcgccgt caccgattaa cacctgtctt tgcaaatctt ctaaaagtcc 1162561 cattgtctgc ctcctttatt cacatcagca aggaaaaaag agaaataaaa aaagtcctct 1162621 taagaagaag actttgtcag tgattttgtc tcttcttatc ttccaagctg ttcgagcttg 1162681 ctggatttag caccttggtc atggctgatc gccattacac cggttgctga agcttcgtcg 1162741 ggccagtccc tctgcttctc ttgataagaa cggatatgaa attttcgtgt caggaagtgc 1162801 caaaagatat ctggcgtttt tccctttctc caaatttacc gaaaataaag acaataatca 1162861 ataggaatca gaaaatttat ctgaaattta taaattgaac gtcaattggc agatctgctc 1162921 cccgtacagc tgagataatc tgctgcaggt catctttgtt ttttccggtg acacgcactt 1162981 gatcatcctg cacctgagac tttactttca gtccggagtt tttgatgatc gtattgattt 1163041 tttttgcgtt gtccttgtca atgccttgaa caagctttgc acgctggcgc accgttccgc 1163101 ctgacgcgtt ttcaaccttg ccgtaatcaa tgttttttgt cggtacgttt cgtttaatca 1163161 atttgctgac cagcacatct ttcagctggc ttaatttgaa ttcgtcatcg gaaacgagga 1163221 ccagctcctc tttatctaaa gaaatgtcgc ttttgctgcc tttaaagtca tatcgggtac 1163281 tgatttcctt cagtgcgatt tggattgcgt tttgcacttc aggcaattcc accttggata 1163341 caatatcaaa tgaactttct tttgccatat gaaaacctcc ataacattta acttatgtgt 1163401 tgattatagt agaataaaga gaaacttcca acagaacaaa gaatcaattt gtgatgattg 1163461 gaaaaaatgt taacaaaatc cgcagagaat aagcggaaca ggaaggacga tagcatgaga 1163521 ccagggcagc aattaacctt gagtatagat caccaaaccg acttcggtta ctttttaacc 1163581 gatggggaag atacgattct cttacataac agtgaaatga ctgaggatat cgaggacaga 1163641 gacgaagtag aagtctttat atacgtagac cagcaggaaa ggcttgcggc cacgatgaaa 1163701 attccgatca tcagcgcgga tgaatatggc tgggttgaag tggtggataa agtggaagat 1163761 atgggcgttt tcgttgatgt cggtttatcg aaggacgcac tagtcgcaac tgagcatttg 1163821 ccgccgtacg aagatgtctg gccgcaaaaa ggggacaaac tttactgtat gctgaaggtg 1163881 acgaaccggg ggcgcatgtt tgcgaaacca gcgccggaag atatcatcag cgaactgttt 1163941 accgacgctt cagaagatct gatgaataaa gagctgacag gtacggtgta caggctgatc 1164001 gcatcgggtt cattcgtgat cacggatgac ggtatccgct gttttattca cccgtcagaa 1164061 agaaaagagg agccaagact gggttcaaga gtcacaggcc gggtgattca agtgaaagaa 1164121 gacggttcag tcaacttgtc gctgcttccg agaaaacagg atgcaatgtc agttgatgct 1164181 gagtgcattc taacgtatat gagaatgaga aacggtgcca tgccgtacag tgacaaaagc 1164241 cagcctgacg atatcagaga acgttttaat atgagcaaag ccgcctttaa acgcgcgctg 1164301 ggccatttga tgaaaaacgg aaaagtgtat caggaaaatg gatggacata cgagaaaaaa 1164361 tagcatgaaa acggctcgcc tgcagcagac tgcggagcga gccgtttttt tatgtctagt 1164421 ttaattcatc aaccagcgtt ctgattgcca tttcgcgatc cacattgtct gaaatcgcaa 1164481 tcggcgtaat atcaatggcg agaatgatca gaatcagggc acctgctgca gcaacataag 1164541 aaacataata gaaatagtta gcggtatcaa cagtgttgac aagctcggcc tgaactctgg 1164601 atgtatcatc cttagaagcg gcgatttcct ttgcagcttc tactttttct tcaacgattt 1164661 gacctgcttt tttcagcagt tcatccactt tcaatgcatc tttgctgtaa acagctttct 1164721 tcaggttatc aaaaaagtca gcatcctctt ttttaatatc agcgacaacc tgattggcaa 1164781 aagcctttgc ctgttttgtg ttgagtttgt ctgtcatcgc tttattaaag acctctggaa 1164841 gctgtttgcc aacttcccct tgggcaaaca caaagccttt aaaaatttcc tcacctgaat 1164901 actcaagctg ctttgcctgt gccacacttt cttgctgctt caccaaaaac acagtcgtca 1164961 ccaatacaac cgacaaaaat actagaaacg ccttcttcaa actgaaacct ctcccttctt 1165021 gtgtttttta ttccacaaca gtctgcgaat atatgtaaat tgaatcgtgg aatcgatagg 1165081 agtgagatac aatatcaaaa tgccggccat gataatcgaa aaactgatga ggcccagcat 1165141 gactgcaaaa atctcatgca taaaaacagc gatgatcaaa atcaatctcc aatgcttctt 1165201 cggcgcaaac agtgccgcga agatgacaat ttgaaccagc agcgtccccc atgtcggaat 1165261 caccacgaac ggacttgtta caattggctt cgttaacgcc tgaaaaaagc cgttgaagcc 1165321 aatggttttt tcctgggcga aataatagac ggccgttccg tccacccatt cctgctgaga 1165381 tagcttagcg acggtagagt gaaaataaag caccgccact tggattctga tcacaaaata 1165441 agaaataaaa gctgttattt ttccaagtgt tcttttgccc tctataggtc tcgtactcca 1165501 atgccatttt ctcggatcgg tcagcgtgat gggaagcaat aaaaaggtca tgactgctgc 1165561 tgcctgctcg cctccgtcga tgacgatcag cgatgactgc aggctgtaac tgacatacca 1165621 atgcagaacc ccggtgattc tggggcgcca gccaatgaca acaagcacca gaatggcaat 1165681 gcagacccat ctgaaaagat ttaacatcat atagttattt tcgccgagac aaaagagact 1165741 gagattcatt ttacaagctg gatagctgct gatcccgctg gctggcttca taatgaggct 1165801 cgggtgattg atgagcagcg tcagcaggct ggatagcgca atgatgcttc gcgcgaggcc 1165861 atatacattt gtccacgggt ttctttcgtc ccatctggtg atggtctgtt ttatgttttc 1165921 gagcatgaga tcacaacctt gactatgctt tttacctgat aagacgaagg ggtatattta 1165981 gaatagctcc aaggaacaat atcctctttc gtcaaatagt agctgccaca aagcagcggg 1166041 cggggagcgg gtgtttttaa ttgcacggtt ttggctttgc ttttgcatgc gccgaggtcc 1166101 ttttctttac atgctgtcca ctgttccttg ccgacttggc tgtagatcac gcccatttca 1166161 acgccttgtg accgcccata ccgatacagg ccgaataggt tgtcagccct catattgggc 1166221 catctgacct tggcgctggc attttcagcc tcatataagc cgattgcagt atcacgcgga 1166281 tttttgctaa aaaagcccca gccctgaggg aggatgctgg acatgagaaa tttggagtcc 1166341 tttgtcagcg gaatcggggt tgtccctaag ctgccaataa tagaaaacag aaatagcgaa 1166401 ccccaaagga ttgaaaaaat gacaaaaaat gatatcgatt tctgcattcg actgctcctt 1166461 ttaacctgaa gaatcgtttt tacacttttc ataatataaa aacatttatg taataaaaag 1166521 gttaaaaagt atgagaaatt ccatttttgt taaaaggaaa aacaggacat tttacactgc 1166581 tatatgtgat tgatatatag tgtttttttc gatatattta aaccatgaaa acgaatcaag 1166641 ttaatgaccg ctggattgtt caatttcgaa aagggatttt cgagctggcc atcctatccc 1166701 ttctgcgttc taaaccgatg tacggttatg agctgacgtc atccttaaaa accacctcgg 1166761 cgctggctat ttcagaggga gcgatttatc cgattttgaa acgtatgacc gagaagggat 1166821 ggatcgaatt tttttgggaa gattcactgg acggcccgaa aagaaagtat tacaaaatga 1166881 cgcaaaaagg agaagaaatg ttaaaagaac ggctggagaa atacctggaa acccatcaag 1166941 ccttactgtc tttatcgggg gatttgctat gaatggacag cttatcattg accgatacat 1167001 ggaggaacta aatgcagagc tggcgaatat gcctgatgta gagagagaaa acgctatcga 1167061 cgaattaaag gggcatatca ccgctttcgt tcaagacaga atcaaagccg gccttagtga 1167121 agaggaactg caggaagctg ttgaatctga attttctcat ccgaaggagc ttgccgaatt 1167181 gatgatgggt gatgggggag agacgaaaag gaggaggtct ttattgggca aaagctggat 1167241 ttcggtcctt ctcattgtca cgattatcgc cctgccgctg ctgccgtccg acttcagaca 1167301 tctgccgctg gctgtttatt taatggtgct cgccggatat gtatggaagc ggaaaaaatt 1167361 ggtgatgttt gcaggtgtca gaaaaaacaa aatgcgctct caaaaggaga ttgtcaagat 1167421 ttcgcgagtc ggtgcggttt atctgctgtt tttagcagtg gtgctccttt tgagcccgtt 1167481 cctcaatgcg cttgtcgtcc tgctgctgat tgcagtaagc tgcgccgctt tttttctttt 1167541 tcttaacatc aagtaatctt gtaggaggct gtaagatgga aatcagcatc aattatctat 1167601 taattgtcat cgcgctttta ttctttgtgg ttgcctattt tgtcggaatc aaaaaacaaa 1167661 cctggatgtt ggctgggttt aacgaggcgc gtatacggga taaagatcgg ctggccagaa 1167721 tagcaggcta ctttttcttg aattccggtt tgttcatttt gctgaatagt tttatctcat 1167781 ttcaaggtca ggagcagctc atacctccgc ttatactggc atatggagca ggggttatta 1167841 tttatgtcaa taaaaaatta gtagagtaga aaaagaaggg cagagcgaaa tatctctgcc 1167901 cttctttttt gggaaaataa gaacgaagca ccacatacaa gtttttgtat ttttgatagg 1167961 atgaagaaaa atggtagatt ccaaaatagg aaggatgtgg tgttttgcgc aacttgacca 1168021 agacatctct attactggcc ggcttatgca cagcggccca aatggttttt gtaacacatg 1168081 cctcagctga agaaagcatc gaatacgacc atacgtatca aaccccttca tacatcatcg 1168141 aaaagtcacc gcagaagccg gtacaaaaca caacccagaa agaatcgcta ttttcctatc 1168201 ttgacaagca tcaaacgcag tttaagctca aagggaatgc gaacagccat tttcgcgttt 1168261 cgaaaaccat aaaggatcca aagacaaaac aaacgttttt taaattaacg gaggtttaca 1168321 aaggaattcc gatttacggc tttgaacaag cggtcgcgat gaaggaaaac aaacaagtga 1168381 aaagtttctt tggaaaggtg catccgcaaa tcaaggacgt ctccgtcaca ccgtctattt 1168441 ctgagaaaaa agcaatacat acagcaaggc gtgagctcga ggcttccatt ggaaaaatcg 1168501 aatatcttga tggggaacca aaaggcgaat tatatatcta tccacacgac ggtgaatatg 1168561 atctcgccta ccttgtgaga ctctcgacat ctgaacctga gcctggctat tggcattatt 1168621 tcatcgatgc caaaaacgga aaggtcatcg agtcctttaa tgccattcat gaagcggcag 1168681 gtacaggaat cggcgtgtca ggtgatgaaa aaagctttga cgtcacagaa caaaatgggc 1168741 gcttttattt ggctgacgaa acaaggggaa aagggatcaa tacatttgac gcgaagaacc 1168801 tgaacgaaac cttgtttacg cttttgtctc aactgatcgg gtatacgggc aaagaaatag 1168861 tcagcggcac gtccgtattt aatgaacctg cggctgtaga cgcacacgca aatgcgcaag 1168921 ccgtttacga ttattacagc aagacatttg gccgtgattc ttttgatcaa aacggagcaa 1168981 ggattacgtc taccgtgcat gtcggcaaac aatggaacaa tgctgcgtgg aacggtgtcc 1169041 agatggtata cggggatgga gacggttcga aatttaagcc gctgtctgga tcgctcgaca 1169101 ttgtcgcgca tgaaatcaca cacgcagtca cacagtattc cgccggtctt ttatatcaag 1169161 gagaacccgg tgcattaaat gagtccattt ctgacattat gggcgcgatg gctgaccgtg 1169221 atgattggga gatcggcgaa gatgtctata ctcctggtat tgcaggagat tcattgcggt 1169281 cattggagga cccatctaag cagggaaatc cagatcatta ctcgaaccgc tacacaggaa 1169341 cagaggatta tggcggagtc catatcaatt cgtccattca caataaagca gcttatcttc 1169401 ttgcagaagg aggcgtgcac cacggtgtac aggttgaagg gattgggcgt gaagcaagtg 1169461 aacaaattta ctatcgggct ttaacatatt atgtaacggc atctacagat ttcagcatga 1169521 tgaagcaagc ggcgattgaa gctgccaatg atttatacgg tgaaggctcg aagcaatcag 1169581 cttcagtcga aaaggcgtat gaggctgtcg gcattctatg agcaaacaaa aacagtcagg 1169641 acacagagtc tgactgtttt tgtttgctca ttttcttaaa aagaatatcg ccaatgtacc 1169701 tggaccggca tgcgagccga tggctgaact gattggatgc ataatgattt ctttcggctt 1169761 gaacgcttcc tcaatcaggt gtttcatatc cgtggctttt tctttgttcg cggcgtagct 1169821 aatcccgacg gtttgattgc tccaatcatc cccgcgctct ttcataagct cgatgatccg 1169881 tttgaaaagt ttcttctgtc cgcgaatttt ttccagaggc acaagcttgc cgtcctccat 1169941 ctgaagcagc ggtttaatat tcaacaggcc gccgacaaaa gcggacgttt tggatatccg 1170001 gccgcccctc gcgagatatg ttaaatcatc aacggtaaaa atgtgttcaa gctggctgca 1170061 aaagttcttt acagacgttt caatttcttg tattgtattc ccgttgatac agagatcggc 1170121 agcatgccgg acagccagac cgtatcctaa tgaagcgcat ttggaatcaa tgacccgcaa 1170181 atcgaaatcg gggaattcct ccttcacttc attggcgatc attacagctg tctgatacgt 1170241 gccggagaga cctgaggaaa aggcaatgta aagagcggga tcacctgttt cggcatattg 1170301 caaaaacaca tttttaatcg tttgcggtga ggcttgggac gtcttaggcg tttctccatt 1170361 ttgcatcgct tcaaatattt gatccgcatg aattgtgact gcatcttcga attctttatc 1170421 gccgagagaa accctgagcg gaataaagcc aatgcctttt tcttcaaaat aagaacgagg 1170481 caaatcagtg gcgctgtcag cgatgagatg aactgtcata ttgcttccct tctttccgtt 1170541 atcgctcgtt atcatgagag ttaagccaac tatatcatat taatttgcca aaatcgtgtt 1170601 caaatatttg ttttaaggga aaacataata aagaagaaag agcggaggaa catgccatgg 1170661 tactagatca aacaaaaaaa ttactcatcg tcatcatcgg cgctttactc aatgctgccg 1170721 ggctgaactt atttttgata cctgcagatg tatatgccag cggatttaca ggtgttgccc 1170781 agcttttatc aagcgtcgtt gatcaatatg ccccctttta catatcgacg ggaacgctct 1170841 tgttcctctt aaacattccg gtcggtattt taggatggct gaaggtcggc aaatcgttta 1170901 cagtgtacag cattttaagt gtcgcactca ctactctgtt tatggggatc ctgccggaaa 1170961 caagcctgtc acatgacatt ttgctgaacg cggtgttcgg cggcgtcatt tccgcagtcg 1171021 gtatcggctt aacattaaaa tacggagctt cgacaggcgg gcttgatatc gtcgccatgg 1171081 tacttgcaaa gtggaaggat aaacccgtcg gcacgtattt cttcattctg aacgggatta 1171141 tcatcttgac ggcaggatta ttgcaaggtt gggagaaagc attatatacc ctggttacac 1171201 tatatgtgac aacgagggtg atcgacgcca ttcacactcg ccacatgaag cttacggcaa 1171261 tgattgtgac gaaaaaagcg gacgaaatca aggaagccat ttacggaaaa atggtgcgcg 1171321 gcatcacaac tgttccggca aaaggagcat ttacgaacga acagaaagaa atgatgatta 1171381 tcgtcatcac gaggtatgaa ctgtacgatt tagaaaagat cgtcaaagaa gttgatccaa 1171441 aagcatttac gaacatcgtt caaacgacag ggatttttgg tttctttaga aaagactgac 1171501 gaaagcaggt ggaagtcgtg aaacggctgc ttgtgatgct cctccccgtg ctgcttttga 1171561 taggctgcgg gaaagatgag cagacagaac ccgataagga ggtatcaggc ggaatggaga 1171621 atcaagaggt tgttttatct attgacgcaa ttcaggagcc tgaacaaatc aagtttaaca 1171681 tgtcgctgaa gaaccaaagc gaacgtgcta ttgagtttca attcagcaca gggcaaaaat 1171741 ttgaacttgt cgtgtatgat tctgagcaca aagaaagata ccgttattcg aaagaaaaaa 1171801 tgtttacgca ggcttttcaa aacctgacgc ttgaatctgg agaaacatat gatttctctg 1171861 atgtgtggaa ggaagtccct gagcccggaa cctatgaggt aaaggtgaca tttaagggca 1171921 gggcggaaaa tctcaagcag gttcaggctg ttcagcagtt tgaagtcaaa taagaggcta 1171981 tggcgagtcg ccatagcctt tttttattgc agtttgtcca gctgattttg aaattgatgc 1172041 aactgttgac gttccgcatc tgtcgaattg gcatacgcag aagatacagc atttttggct 1172101 ctcagaatcg cttgctcctg atcgccttcc tcaaagccgt ttgtcaccat gaccgcctgt 1172161 tgaacaaatg attttgcctg ctgaaacagt tcatttctca tttaatattc atactgcctt 1172221 tcagccgagt ctcgtgccgc ggcatgctgg tgagcttctt ctaaagtaga ccgatatgga 1172281 aatcttgcgg cgtgtagccc gatggagtct ttaccctgct gaataaacct tctggatttg 1172341 cttcgtttac ccattttgag actgccccct tccatacttt gacgagatga gtcgtcttca 1172401 atagtatggt ggggtaaagt aaggtttatg agtgggaaaa attaatacgg accttcttta 1172461 aagtgagaaa tattctttca aaaaccttgc cacgccgtcc tcttcatttg tggccgtagt 1172521 tcggttggca atctgcttga ccgcgtcaat tccatttccc attgcaacgc cgcagcctgc 1172581 aaattcaagc atttccaaat cgttatcctc atctccaaaa gcaatgatcc gctccctcgg 1172641 cacgccgtaa taatcgctga ttttctgcag gccgaccgct ttattcatgc cgcttttgat 1172701 aatttcaatg acatgccaag gagcggccca tcttctatgg tcgatcacct cggcatgcac 1172761 atccgataaa tatgagcgta ttgccggcac atcctcttcc tttgcatgta tgagtacgga 1172821 cgtcacatct tcaccgagat tttcccgcaa gtctccgacc gttacatttg ttgtgttcat 1172881 gttaaaggca tctatcaggt gctcatcatg gtaatgaaag tatacgtcgt caatcacttc 1172941 agcaagcacg ttatgtacgt tgtagctctc gctgatatcc acgagctgtt tgacaacatc 1173001 aagcggcagt gacgtatgat accgtcccca gctgtcgtct tgcggatgat ggacaaatgc 1173061 tccgttaaaa ttgacaattg gcgttgtcag ctccatctgc tggtagtaca tggaacttga 1173121 acgatacgga cggcctgttg agatgcagac ataatgcccg tcatctttta ggcgctgtat 1173181 cgtatgaagg gtgttttcag atatggtttt atcatccttt aataatgttc catctaaatc 1173241 taatgcgatt aaatagggtt ttgtctccat gaaaagctcc tttaacctta gattttgctt 1173301 gttttgcctt acttacagtg tagcttttta ccatctttat tgtctacatg ttacacttat 1173361 gattatggtt atcctaagga ggggcacatt gtgatacaaa ttgagaatca aaccgtttcc 1173421 ggtattccgt ttttacatat tgtaaaggaa gagaacaggc accgcgctgt tcctctcgtg 1173481 atctttatac atggttttac aagcgcgaag gaacacaacc ttcatattgc ttatctgctt 1173541 gcggagaagg gttttagagc cgttctgccg gaggctttgc accatgggga acggggagaa 1173601 gaaatggctg ttgaagagct ggcggggcat ttttgggata tcgtcctcaa cgagattgaa 1173661 gagatcggcg tacttaaaaa ccattttgaa aaagagggcc tgatagacgg cggccgcatc 1173721 ggtctcgcag gcacgtcaat gggcggcatc acaacgcttg gcgctttgac tgcatatgat 1173781 tggataaaag ccggcgtcag cctgatggga agcccgaatt acgtggagct gtttcagcag 1173841 cagattgacc atattcaatc tcagggcatt gaaatcgatg tgccggaaga gaaggtacag 1173901 cagctgatga aacgtctcga gttgcgggat ctcagccttc agccggagaa actgcaacag 1173961 cgcccgcttt tattttggca cggcgcaaaa gataaagttg tgccttacgc gccgacccgg 1174021 aaattttatg acacgattaa atcccattac agcgagcagc cggaacgcct gcaatttatc 1174081 ggagatgaaa acgctgacca taaagtcccg cgggcagctg tgttaaaaac gattgaatgg 1174141 tttgaaacgt acttataaag cactaagtta ttaacaagag ctgaatttac gttatactgt 1174201 agaaaaaagg agtgagggaa cgtggaagaa gcattaaaag aaaacatcat gggcgccctg 1174261 gaacaggttg tcgatcctga gcttggcgtt gatatcgtga acctcggctt ggtatatgac 1174321 gttgatatgg atgaagatgg cttgacgcac atcaccatga cgctaacatc aatgggatgc 1174381 cctttagcgc cgattatcgt ggatgaggtg aaaaaagcat tagcggacct tcctgaagtg 1174441 aaagacacag aggttcacat tgtatggaat ccgccttgga ctagggataa aatgtccaga 1174501 tacgcaaaaa ttgcgcttgg cattcaataa aacaaaaaag gacagcctga catgtgaggc 1174561 tgtccttttt tacagctgaa aggagtgaaa ggaaatgatg tacctgctgg cagttttatg 1174621 cccgccgctt gctgttttgt tttcgggaaa accgtttcag gccttgctga atctcatatt 1174681 gacctgtatc ttttggctgc cgggcgcgat tcacgcctgc tttatcgtcg ccgaccgccg 1174741 tgccgaaaaa cgggcaagaa gataatttgg aaaaatgagg acgcagtcat ggtataatgg 1174801 tcataaaaac agcagggaga gcactatgaa aaagaaattg cttgcattcg cgctttgtac 1174861 tggcgcgtat gcggccctgt ttgcgtactc tgtgaactca gagcaaaaaa cagccacaag 1174921 cgagatgacg gatgtcagcc gcctgatgcc tgtaaaaata aagcagacag tgaaagggca 1174981 ggaagaggaa atgctcattg acacagtcaa agaggcaaat cgaaaaaaca taaaaatttc 1175041 aatcgccggg gcccagcact ccatgggcgg ccatacatat tatgaggacg gcatcgttct 1175101 cgacatgacg ggctacaaca aaatcctgtc actcgatcaa gagaagaaaa ccatcagggt 1175161 gcaaagcggt gcaacgtgga atgatatcca gaaatacgtg aatccatacg gactcgcggt 1175221 aaaagtcatg cagtcacaaa acatttttac aatcggcgga tctctcagcg caaatgcaca 1175281 cggacgtgat attcgctacg gctcgctaat tgatacagtc aaatcattcc ggcttttaaa 1175341 agctgacggg atgattatca ctgtcactcc aaaagatgat ttgtttacgg cggtcatcgg 1175401 agggtacggc ctttttggcg tgattcttga tgtaacgctt gagctgacag atgatgagct 1175461 gtatgtcatg aagacagaaa aaatgaatta cagcacatac tcagactatt tttcaaagca 1175521 tgtaaaagga aatccagatg tccgaatgca tctggcgcga atttcaacag cgaaaaaagg 1175581 atttctgaaa gacatgtatg tcacgaatta cgtattggct aatcatcagg atcagctgtc 1175641 ctcatacagc gaacttaaag aagacgagta tacgggagcc acaaagtttg cactcggctt 1175701 gtcaagacgg tatgaatggg ggaggaattg gctgtgggac acacagcaat cctatttcct 1175761 gagccagaac ggcacagaga tttcacgcaa taacgtcatg cggtccgaat caaagtttct 1175821 tgagtatgaa aacaatgaca acacagatgt tttgcaagaa tactttgtgc ccgtgaagga 1175881 gtatgggtcc tatattgatg acctgagaca aacgctgtcg gacgaagatc tgaacctgct 1175941 gaacattacg atccgctacg tgcagaaaaa tgaaaaggcc gacctttcct atgcgaagga 1176001 cgatatgttt tcgctcgtac tattaataaa cgagggcttt tcaaaagaag accaggcaga 1176061 taccgcccga atcatcaggc gcatgacaga cgttgccatc aagcacggcg gcagctatta 1176121 tctgccttat atgacctacc agacaaaagc gcaaatgaga caggcatatc cgaaaagtga 1176181 agcgtttttt cagaaaaaac gaacctatga cccggatgag cgctttatga attactttta 1176241 tcagaggtat aaataatggg gaaaaacaaa ttaaaatggc tgacattatc acaaagcagc 1176301 gtgtttttcg caagcagctt aatctttccg ttttatattc tgtttgtgaa aaatatcggc 1176361 tcaagctaca cacagttcgg tttttcctac ggattgttcg ggttgagcgg agcgcttatt 1176421 tacccgctcc tcggacggct gtctgaaagg tttgacagcc gttattttct gcttctgaac 1176481 tcgtggggga tggctgttct gcttttatat gtcccgcata tcggaagcgt cgttcaagtg 1176541 tatatcgtcc aagtgctgtt agggctcttt ggagcgatgc aaaagcatgg agaaaaagtg 1176601 ctgatcgcta attttacaga cagtggagag cgtggaaaga agatcgggaa ttaccatttt 1176661 tggacagctg tcttttcagc agcagccatt atgctcgggg gctttctcgc tgactttttc 1176721 acagtgcaaa tgatttttta tgcaagctct attctatatt ttttgagtgg attgatgatg 1176781 atgaaaacag gctgacgcgg tcagcctgtt tttttatgcg gctgaaatgc ggcaccgcat 1176841 caacgttttt gtgctggagt cgtgctgatt ttttttgagc ggaattccca ttgaacagaa 1176901 aatttataaa tgaataaaaa tattaaatat acgattgaat taatttttat tcatgttata 1176961 atgttaaata atttcacaaa gaccaagagg gtgaacttgt tttgaaaata ggaattgtag 1177021 gtgctacagg atatggaggc accgaacttg tcaggattct ttcgcatcat cctcatgcag 1177081 aggaatgcat actttattca tccagcggag aagggaatgt ctatagcgag ggttatcctc 1177141 atcttaccgg cttagcggat cagcagctga agccgattga tatgaatacg atcaaacacg 1177201 aaatagatat catgtttctc gctgcgccgc ccggagtatc aagtgaattg actccaaagc 1177261 tggcagacgc gggaattacg gttattgatc tgtcaggtga tctgaggata aaagaaccgg 1177321 ctgaatatga aaaatggtat aaacggacag cggcaccgaa ggcggtgatt caagaggcgg 1177381 tatacggtct ggcagaactg aatcaactgc aaattcaaca ggcgaaactc attgccaatc 1177441 caggctgttt tccaacagct gttttgcttg gcctcgcgcc attggctcaa aagaaactgc 1177501 tcgatgaatc tttcgttatc gttgacgcga agaccggtgt ttccggagcg ggaagaaaag 1177561 catccatggg aactcatttt tctgagctga acgacaattt taaaatttat aaagtcaatg 1177621 aacatcagca cacgccggaa attgagcagg cgctgaatga atggcagcca ggtctcgggc 1177681 ccattacatt ttcggctcac ttggttccga tgacaagggg catcatggcg acgatgtata 1177741 ccagattaac ctgtgaccta accgcagatg acctgcatga tttatattcg gaattttacc 1177801 aagattcata ttttgtgaga gtgaggccaa aaggtcagta cccgcaaacg aaagaagtgt 1177861 acggcagcaa tttctgtgat atcgccgtga ccctcgatga gagaacgaac agagtcacga 1177921 tcgtctcggt aatcgataat ttaatgaagg gtgccgccgg tcaggcagtg caaaacttta 1177981 atttgatgaa tggctggaat gaagaaactg gactcaccat cacgccaatt tatccataga 1178041 acgggagaga atcgaaccat gattcagtta agtgaagatc aaattgtaaa agtaacaggt 1178101 gatgtatcct cgccaaaagg gtttcaggca aagggtgtgc attgcggact gcgctactcg 1178161 aaaaaagacc tcggcgtcat tatcagcgag acaccggccg tgagtgcagc agtttatacc 1178221 caaagccact ttcaggctgc tccgatcaaa gtgacacaag acagcttaaa gcacggaccg 1178281 acactgaaag ccgtcatcgt caacagcgcc attgccaacg cctgcacggg agaacagggc 1178341 ttaaaggacg catacacaat gcgggagagc tttgcttcac agcttggcat tgagccggag 1178401 cttgtcgctg tttcatcaac gggtgtcatc ggcgagcatt tagacatgga aaaaatccac 1178461 gcggggatcg aactgctgaa agaaacacct gcgggatcag gcgattttga ggaagcgatt 1178521 ttaacaactg atacggtgat caagcagacg tgctatgaac tggcaatcgg cggcaaaaca 1178581 gtcacgatcg gcggagcggc caaaggctct gggatgatac acccgaacat ggccacgatg 1178641 ctgggatttg tgacaactga cgcggcaatc gaagaaaaag cgctgcaaaa ggcgcttcgg 1178701 gaaatcactg acgtttcatt taaccaaatc acagttgacg gagaaacatc cacgaacgac 1178761 atggtattag ttatggcgaa tggctgcgcc gaaaacgagt gcctgacaga agaccatcca 1178821 gactggccgg tctttaaaaa agcgctcttg ctcacttgtg aggatctagc taaagagatt 1178881 gccagagacg gagaaggcgc gacaaaacta attgaagccc aagtacaggg agcgaaaaac 1178941 aatcttgatg caaacgtcat tgccaaaaag attgtcggct caaatcttgt aaaaacggca 1179001 gtatacggaa cagatgccaa ctgggggcgg atcatcggag ccatcggaca ctccgcagca 1179061 caggtgacgg cagaagaagt agaggtttat cttggcggcc aatgcctgtt taagaataac 1179121 gaacctcagc cattctctga atctatcgcc aaggaatacc ttgaaggaga tgaaatcacc 1179181 attgtcatca agatggctga aggggacgga aacgggagag cgtggggctg tgacctgacc 1179241 tatgactata tcaaaattaa cgcgagctat cgcacgtaat aaaggggagc gaaatgaaga 1179301 aaacaatcgt ttttaaatgc gggggaagcg tcatccgtga gctgtcggag gaattttatc 1179361 aaaatctgaa agagctgagg gcgtcaggct ggaagctggc aatcgtacat ggcgggggac 1179421 cggaaatcac aaatatgctg aaacggttaa atatcaagac agagttttcg ggcggacaga 1179481 ggaaaacaac gaagccggtg ctggaagtgg cggaaatggt tttatccggt tctgtcaata 1179541 aatttttcgt tgctgagctt gccaaacacg gactgcgagc cgcgggcatt tctggtaagg 1179601 atggcggtct tttggaggct gattatctag atccggaaac atacggagaa gtgggagaaa 1179661 tcaaaaaagt cgatgcgtcc atggtgaacg cgctgatgga aaatggcatc atccccgtta 1179721 ttgcgccgct gtctatgaca agcgactgca aaacgctgaa tgtaaatgct gatctggctg 1179781 cttcagcagt cgccggagcg cttgaagccg ataagctgat gttcgtcacg gatgtcgatg 1179841 gaatcatgaa ggaaaagcag cgtctggacg tcctgacccc taaggagatt cagatgctga 1179901 tcaagcagga agtgatcaca ggagggatga tcccgaaggt caattcagcc ttgtcagctt 1179961 tatcagatca ggtgtctgaa gtcatgatcg taaacggtaa aggatcattc ttcgcagaac 1180021 aaacctttca agggacaaaa attgtcaaag caaaggaggc tgtttcatga gcagcttgtt 1180081 tcaaacctac ggccgttggg atattgacat caaaaaagca aagggaacgt acgttgagga 1180141 tcaaaacggc aaaacgtacc ttgatttcat tcaggggatt gcggtatcaa atctaggaca 1180201 ctgccatgaa gcggtgacag aggcagtcaa aaaacagctt gacagcgtat ggcacgtatc 1180261 caacctgttt caaaacagtc tccaagagca agcggcgcag aagctggcag cgcatagtgc 1180321 gggagatctt gtctttttct gcaacagcgg cgcggaggcg aatgaaggtg cgataaagct 1180381 tgccagaaaa gcaactggaa aaacaaaaat catcactttt cttcagtcgt tccatggccg 1180441 cacgtatgca gggatggctg cgaccggaca ggataaaatc aaaacaggct tcggcccgat 1180501 gcttggaggc tttcactacc tgccatacaa tgatccttct gcttttaaag ctcttgggga 1180561 ggaaggcgat attgccgcgg tgatgcttga aacagtgcag ggagaaggag gagtcaatcc 1180621 ggcgagtgct gaatttttat cagccgtaca gtcgttttgc aaggaaaagc aagcccttct 1180681 cattattgat gaaatccaga ccggcatcgg acggacggga aaaggcttcg catatgagca 1180741 cttcggactc tcaccggata tcatcacagt cgccaaagga ttgggaaacg gctttccggt 1180801 cggcgctgtc atcggaaaga aacagcttgg agaagcgttt acccctggtt ctcacggaac 1180861 gactttcgga ggaaacatgc tggcgatggc tgctgtgaat gccacattgc aaattgtatt 1180921 ccagcctgac tttttgcaag aggctgctga caaaggggcg tttttaaaag aacagcttga 1180981 ggcagagcta aagagccctt ttgttaaaca aatccgaggt aaaggattaa tgcttggaat 1181041 tgagtgtgat ggcccggttg ctgacattat tgctgaattg cagacattag gcttgcttgt 1181101 attgccggcc ggcccgaacg tgattcggct gctgccgccg ctcaccgtga ctaaggatga 1181161 aatagcagaa gccgtcagca agctgaaaca ggcaatcgct catcattccg ctgtaaacca 1181221 gtgatttttt ttcgatataa aggcataaaa attcattttt ataattaatt attcatcaag 1181281 aggtgggctg ttagatggaa ggttatttag tgttagaaga tgggacatcg ttcagcggcg 1181341 agctggacgg tcatgaaaac tgcacgggag aagctgtttt tttcacagga atgacaggct 1181401 accaggaagt gctgacagat ccatcatata agggacagat tattgtattt acctacccgc 1181461 tgattggcaa ctacggcata aatgaaaagg attttgaaag caagaaaccg caagtaaaag 1181521 ccgcggttgt ctatgaggcg tgtgatcact tttctcatta tgaagcggta tacagcctca 1181581 aggagtatct acagaaatgg aatattccgc tgttaaccca tgttgatacg agggctgtcg 1181641 tgaagaaaat ccgggcaaac gggacgatgg gtgcgacagt cacagcctct aaagaaggag 1181701 ctgagattgc ccttcaacca gagaatgtgg cagagcaggc ttccgcccag gaaatcagca 1181761 cattcggcga cgggaataaa catatcgctc tcattgattt tggctataaa aagtcaatcg 1181821 catcatcact tgtcaaacga ggctgcaagg ttaccgtggt gccataccag caaatggagg 1181881 ccgtatacaa catcaaaccc gatggaattg tgctatcgaa cggacctgga gatccgaaag 1181941 ccattcagcc atatttagga aagatcaaaa gcatcatcag ccgctttccg actctaggca 1182001 tttgtctcgg acatcagctg atcgcgctcg cgtttggagg gaatactttt aagctgccat 1182061 tcgggcacag gggagctaat catccggtca tcgaccgtaa gacgaaacgg gtctttatga 1182121 caagccaaaa ccacagctat gtggttgatg aacagtcgat taatgaagaa gagctcacca 1182181 tcaggtttca tcatgtcaat gatacgtcag ttgaagggct tgcccataaa aaactgcctg 1182241 tcatgagtgt tcaattccac ccggaagccc atcccggacc tgcggaaagc gaatggattt 1182301 ttgatgatta tctaaagaat gtgataccag caaggagaga aatcgcgcat gcctaaagac 1182361 accagtattt caagcatatt agtaattggc tcaggcccga tcatcatcgg gcaggcggca 1182421 gaatttgatt attcaggcac tcaagggtgc atcgcgctga aggaggaggg ctaccgggta 1182481 attctcgtca acagcaatcc ggcgacaatt atgactgatg aagccttcgc tgatgaaatt 1182541 tattttgagc ctctgacagc agaaagcctg acagccatca ttaagaaaga acggcctgat 1182601 gggcttcttg ccaatttagg cggtcagacc gcgttgaatt tagcggtgga gcttgaagaa 1182661 acgggtgttt taaaagagca cggcgtcaaa ctcctcggca catccgttga aacgatacaa 1182721 aaaggagagg accgggaaaa attccgttcg ttaatgaatg aattaaaaca gcctgtgccg 1182781 gagagtgaaa ttgttgataa cgaggccgat gccctccatt ttgcggaatc catcggtttt 1182841 cctgttatta tcagaccagc ttacacatta ggcggaaagg gcggaggaat cgcccctgat 1182901 aaagaagcct ttacagctat gattaagcag gcgctattag caagcccgat caatcaatgc 1182961 cttgtcgaaa aaagcattgc cggctttaaa gaaattgaat atgaagtcat gcgtgacagc 1183021 aataacacat gcattaccgt ctgcaatatg gaaaatatcg atccggtcgg cgtgcataca 1183081 ggtgactcta tcgttgtggc gccgtcacaa acattgacag acgaagacta tcaaatgctg 1183141 cggacagcaa gtctgacgat catctcagca cttgatgttg taggcggctg caacattcaa 1183201 ttcgcgcttg atccattcag caagcaatat tacgtcattg aagtgaatcc gcgtgtaagc 1183261 cggtcatcgg ctctcgcatc taaagcgacc ggttatccga ttgcgaagat ggccgcgaaa 1183321 ctggcagtcg gatacactct tgacgagctg aaaaatccgc tcacaggctc gacttacgca 1183381 agctttgaac cggcactgga ttatgtgatc gtcaaatttc cgcgctggcc gtttgataaa 1183441 ttcaaaaacg cagaccgcaa gcttggcaca aaaatgaaag ccaccggtga agtgatggcg 1183501 attgaacgga atttagaagc ggcgatacaa aaggcagccg cgtcgcttga attaaaaaat 1183561 atcgggacac accttccaga gctcagcggg ttgtcaattg atacgctatg ggatttggca 1183621 atcactccgg atgaccgcag atttttcgtt gtcatggagc tgttgagccg cagcgtctcg 1183681 attgatgaca tccatgaaaa aacaaaaatt gatccgtttt tccttcatac ctttgacaac 1183741 atcatcaaat tggaaaaccg cctgatggaa gcagggagcg atctctcttt tgaattattg 1183801 aagaaagcaa aggaaaaggg attctcagac gcaacgattg cctcgctgat cagcaaaaca 1183861 gaagaagagg tgcgcgcgct tcgcaaggag atgggcatta cgccttcctt taaaatcgta 1183921 gatacatgcg cggcagagtt tgatgcgaaa acaaactatt tttactccac atatttcgga 1183981 gagaccgatg gagacatcag ccgcaaagag aaaaaacgcg cgctcattat cggatcaggc 1184041 ccgattcgga tcggccaagg cgttgaattt gattacagtg ctgttcacgg tgtgctgaca 1184101 ctgcaagagc ttgggttcga aaccatcatg attaacaata acccggaaac tgtcagcacc 1184161 gattatgaaa ttgcggaccg cctgtatttt gaaccgatga caacggagca tattgtaaac 1184221 gtggcggagc aggaaaatat tgattttgca attgtgcaat ttggcggtca aactgcaatc 1184281 aatgctgctg aagcgctcga aaaagccggc attactcttc ttggcacatc atttcaaacg 1184341 ctcgacgtgt tagaggatcg ggatcaattt tatcagcttc ttgacgagct gggattgaag 1184401 cacgcaaaag gagaaattgc ttatacaaaa gaagaagccg cttcaaaagc gagtgagatc 1184461 ggctatccgg tgttaatccg cccatcttac gttatcggcg gaatgggcat gatcattgtt 1184521 gactcgcaag cccagctttc tcagctgctg aatgatgagg acagcatgcc atacccgatt 1184581 ttaattgatc agtatgtgtc tggaaaggaa gtcgaaattg atttgatttc cgacggcgag 1184641 gaagtcttta tcccgacata taccgagcat attgaacggg caggtgtcca ttcaggggac 1184701 agttttgcca ttcttcccgg accgtccatc acgagcgggc tgcagcaggg catgaaagat 1184761 gcggcacaaa aaattgcccg aaaactttca tttaaaggca tcatgaacat tcaatttgtg 1184821 atcgacaatg gaaacatact cgttcttgaa gtgaatccga gagcgagccg cacggttcct 1184881 gtcgtcagca aagtaatggg cgttccgatg attccgctcg ccacacgtct gctggcggga 1184941 gcgtccttaa aagatctaaa tccggcagtt caaaatcatc atggagttgc cgtgaagttc 1185001 cctgtttttt cttctcatgc gatccaggat gtggatgtca agcttggacc ggaaatgaaa 1185061 tcaacgggag aaggcatgtg tgtcgcatat gattctaaca gcgccttgaa aaaaatctat 1185121 acaagagtct ggagtcaaaa aggaagcatt tatttgcaaa acgttccgga agatgtgaag 1185181 gagttagcag aaaacgcagg ttttacaata catgaaggaa catttgcctc atggatggaa 1185241 caggaaggaa actcgctcca cattaatctg agcggttctg aagaagcacg caaagaacgt 1185301 ttggaagcca tgacgcacgg catccccgtc tttacagaag aagaaactgt gcgggcgttt 1185361 ttacaaagcg gttcaggcca tccgcagcct gtatctctca aagacctcta taaaaaggaa 1185421 gtggcatcat gcacacagtg acgcaaacca gtttatacgg aaaagattta ttaacgttaa 1185481 aggaccttag tgaagaagat ataaacgcct tgctcgcaga agccggtgag ctgaaacaaa 1185541 acaaaattca gcctatattc catggcaaaa ccttggcgat gatttttgaa aaatcatcaa 1185601 cgcggacccg tgtttcattt gaagcgggca tggcgcagct gggcgggagc gccctctttc 1185661 taagccagaa agatctgcag ctggggcgcg gtgagactgt cgctgatacg gcaaaagtgc 1185721 tgtcaggcta tgtggatgcc atcatgatcc ggacctttga acatgaaaag gtggaggaac 1185781 ttgccaaaga agctgacatt ccggtgatca atggacttac cgataaatac cacccatgcc 1185841 aggcgctggc ggatctcttg acgattaagg agataaaagg gaagcttaaa ggcgtaaaag 1185901 tcgcgtacat cggtgacgga aataacgtgg cgcactcctt gatgatcggc tgcgcgaaaa 1185961 tgggctgtga tatctcgatc gcttcaccaa agggatatga agtgttagat gaagcagctg 1186021 aagcggcaaa gacatatgca cttcaatccg gctcttctgt cacgctgaca gatgatccga 1186081 ttgaagctgt aaaagacgcg gacgtgattt attctgatgt gtttacaagc atggggcagg 1186141 aagcggaaga gcaagaacgt cttgctgtct ttgcgcctta tcaggtgaat gcggcgctgg 1186201 tcagccatgc caagcctgac tatacatttt tacattgtct ccctgcgcat cgcgaggaag 1186261 aagtgactgc ggagattatt gacgggccga actctgcagt gttccagcag gcggaaaacc 1186321 gtcttcatgt gcaaaaagca ctgctgaagg ccattttata taaaggggaa tcatcaaaaa 1186381 actgctgagc caaactcagc agtttttttg atggcaacat attcacagcc gcttaggcgc 1186441 atactacagc aaaaaggaaa aggaggaaaa acagtgggac agcagcacca attccggccc 1186501 ggacagaaag cgcctaataa cggtgtctac gtagaaatcg gcgagacagg gagcatggtt 1186561 aaaaaccctc aaaaggtcca tctgtcagca ggggaaatgt tccccgaaac atcaaaccac 1186621 aaccggctgt ggacctacaa aagaaagccg tgaccactaa aaaacccaaa acaataaatg 1186681 ttttgggttt ttggcttttt aatgctggct tgcatttttg ttcataggca tgatttctgc 1186741 taaaaccatg attaagacat acagtacaac agcaatgaca gatgatgttt tgaaattata 1186801 cgtaacgctg ttcatgcttg caaccaagta gcatgccata tgtgataaaa ggaacgtcca 1186861 aataaaggca ataatatatc gcacgtttcc acctcgtcct tctcattcta ttctaaaagt 1186921 tatcatacca tacaaaaagc gaagggggaa tccaatttta gcagaaagtg aggtgacaaa 1186981 agagtctgat tcgtcacact ttaatggtaa aatataaaac gtcaatcagt ataatagcca 1187041 aaaatgtaaa aggctaggac tttaccttat tcgtttcttt tctatttaca taagatagcg 1187101 tgagatgaag tgtgaaagga ggcgggcaag cgatgggaat aacggaaaga tactttcaac 1187161 tgggaacgga gcataatgtc attcatctgc cctatcgccc gaacggcttc ggcatcttta 1187221 tcttggggga cagaacccac tttgtcggac atgattcaag cttttggcag cagcattatg 1187281 gcagaaatca gcttctgagc atgttgatga atgaaggata cactcttttt aacagcaatc 1187341 tgttcggaag gcattggggg gcggaaaaag cagtcaccta tgccaaacag ctgatacatt 1187401 ctgtgctgaa gcaggaaatc ctcaatccga agattcatat tttagcagaa ggcatgggtg 1187461 ctctcgtggc cgatgaactg cttcgttttt ccccggatca tatccgctca gccgcaatgt 1187521 tgaatccttg tctcgatctt caggcacatt atgaatcgga aaaagaaaat aaatttttct 1187581 ataagcaatt tttgaaagaa gtatcgaaaa gctacggaat ttctgaaaaa gaagcggaag 1187641 cgattcgtta taaaacaatt caaagctacc cgagcggcgt accggttcat atatggcagc 1187701 gtatgaccgg agctccatat ccctacagcg tacatgcgga agttttcaag gaaaaacagc 1187761 aaaagcaagg ctcaccggtc gacatgacat ttcatttatt tgagcatcca agcagaattt 1187821 atgcatcaat ttgcaaattc tttcatagtc atgaaaaaga attatagaga atataatgac 1187881 aacagccttc tcttttgcgg aggctgtttt gttttgggaa atgaaaaacc ggaagggcgg 1187941 cagatgcaat ggaatcaacg ctgattgtag gtgcggacga atttttcggc ctttcattat 1188001 gtgagcgaat gatggatgaa ggcatacatg ttgacgttgt tctggcggaa acagaagata 1188061 aaatgagaca aatgtactta gaagaaagac tcatgtggct tgggagaaat gaactctttc 1188121 gccagcttga acacattgga gaccaaaatt atgatacaat ttgtatccag ttcggaagtt 1188181 ttttgccttt agaccaatat gattctcctt atattttagt atatgaagaa gaccgaaaag 1188241 aatgggataa acgtgaaaaa acaggctcgg aaaaaaccgt gatcctgccg aaaatgtacg 1188301 ggccatggaa agaagaaaca gaggaagacg gctattacac aaacgacgtg gctgacgagt 1188361 tgctgagatt cctgttagaa ccaagccgtc atagcaaaga tcagcttttt gaattgcaag 1188421 tcacagagaa aacctcaaaa gaagaagcaa aaacaaaaat tatcgagtgg aaaagacaat 1188481 tttcatcaat tttcgacaaa tattaagaaa aaccttccat gtttcgagtt ttctagatac 1188541 aataaacgta taaaaataat acatgttata gcttgtcaaa aggagttgaa catgacttga 1188601 tcacaaggct tgtcatgatc ttttctgtcc tccttttatt gagtggatgt ggacaaactc 1188661 cgttcaaagg aaaaattgag aaggtcggca tgctctttcc tgatacgatt aatgacctcg 1188721 tatggggcac aaaagggtat aaaggattac tgaatataca atccaaatac aatgtggacg 1188781 tctattataa agaaggcgtt aaaacagaag aagatatcat aaatgcgatt gaggattttc 1188841 ataagagggg cgtcaatctg ctctacggcc atgggagtga atatgctgag gtgtttaact 1188901 tggtcggcga agattatcca gatatggaat tcgtcatttc caatgcgaaa gcgaaagctg 1188961 ataatgtaac aagtgtccat tttagcgggg aagcaatggg cttttttgga ggaatgactg 1189021 ctgcccatat gtcgaaaacg aatcaggtcg gtgtaattgc ttcctttacg tggcagcctg 1189081 aggttgacgg ttttatcaaa ggggccaagt atgaaaatcc ggatatagag gtaaatacga 1189141 aatatacgga tcattgggat gatgatacaa cagcagtaaa gctttatcag aaaatgaaga 1189201 acgaaggcgc ggatgttgtg tatcccgccg gagacgggta taatgttcct gttattcagc 1189261 aaatcaaaaa agacggtctt tatgccatag gctacgtcac agatcaatcg gatctgggcg 1189321 agaataccgt attaaccagc acggtgcaaa atgtggacaa ggcctatgaa atcattgctg 1189381 aacaatttaa taaaggcacc cttgagggcg gcgatcatta ctacgacctg aacacgggag 1189441 tcgttgagat gggaacattc agcccgctcg tcgatcaaga ctttcagcaa agaatcgcca 1189501 agctgatcaa aacatacaac aaaacaggcg agctgccaaa aaacgagtaa tggagtgacg 1189561 tcacatgcag cacgaaaaat cacttgaatt cttgcaaatt gccatgaaat atctccctga 1189621 agcgaaagaa cagcttgaga aatcaggcat tgagctctca atggaggcca tccagccgtt 1189681 tatgaatcta tttacaacgg taatggcgga agcttatgag cttggcaagt ctgacgctaa 1189741 atctgaaaca gaataagaag aagccacttt tttgaaagtg gcttttcaca tgattttctt 1189801 tttaatagcg gagagcatgg gcgcaagctc ctttaaagcg ggcttgattt gatcaagaga 1189861 gttcataatt gaaccgattt ggtccataat atgcatgtaa ttaatcgtct cttcgtcgtt 1189921 tgtctgagaa acctgagaaa cttcctcttg ctgttcctcc tccttctctt ctgttggttt 1189981 tgctgcatcg ccgaacatca ttcttgaaaa cacatccaac tgcatacgcc tcctttccat 1190041 ataccatact ctatgagtaa gatgaactga tagtttagac gaatatattg ccatgtgaaa 1190101 aaaaatagga tagaattagt acctgatact aataattgat cacaacctga ttgatcttct 1190161 aaatttaaga tataaaggag tcttccctaa tgaaagctgg aatacttggt gttggacgtt 1190221 acattcctga gaaggtttta acaaatcatg atcttgaaaa aatggttgaa acttctgacg 1190281 agtggattcg tacaagaaca ggaatagaag aaagaagaat cgcagcagat gatgtgtttt 1190341 catcacatat ggctgttgca gcagcgaaaa atgcgctgga acaagctgaa gtggctgctg 1190401 aggatctgga tatgatcttg gttgcaactg ttacacctga tcagtcattc cctacggtct 1190461 cttgtatgat tcaagaacaa ctcggcgcga agaaagcgtg tgctatggat atcagcgcgg 1190521 cttgtgcggg cttcatgtac ggggttgtaa ccggtaaaca atttattgaa tccggaacct 1190581 acaagcatgt tctagttgtt ggtgtagaga agctctcaag cattaccgac tgggaagacc 1190641 gcaatacagc cgttctgttt ggagacggag caggcgctgc ggtagtcggg ccagtcagtg 1190701 atgacagagg aatcctttca tttgaactag gagccgacgg cacaggcggt cagcacttgt 1190761 atctgaatga aaaacgacat acaatcatga atggacgaga agttttcaaa tttgcagtcc 1190821 gccaaatggg agaatcatgc gtaaatgtca ttgaaaaagc cggactttca aaagaggatg 1190881 tcgacttttt gattccgcat caggcgaaca tccgtatcat ggaagctgct cgcgagcgtt 1190941 tagagcttcc tgtcgaaaag atgtctaaaa ctgttcataa atatggaaat acttctgccg 1191001 catccattcc gatctctctt gtagaagaat tggaagccgg taaaatcaaa gacggcgatg 1191061 tggtcgttat ggtagggttc ggcggaggac taacatgggg cgccattgca atccgctggg 1191121 gccgataaaa aaaggtgagg tgcacacaag atgactaaaa aaagagtagt tgttacagga 1191181 cttggagcat tatctccact tggcaacgac gtcgatacaa gttggaataa cgcaatcaac 1191241 ggtgtgtccg gaatcggtcc gatcactcgt gttgacgctg aagaatatcc ggcaaaagtt 1191301 gccgctgaat taaaagattt taatgttgaa gattatatgg ataaaaaaga agccagaaaa 1191361 atggaccgct ttacacaata tgcggttgtg gctgcgaaaa tggcggttga agatgcagat 1191421 cttaacatta ccgatgagat cgcgccgaga gtcggtgttt gggtaggctc cggtatcgga 1191481 ggacttgaaa cactagagtc tcaatttgaa atcttcttaa caaaaggccc aagacgggta 1191541 agcccgtttt tcgtgccaat gatgattcct gacatggcga caggccagat ttctattgca 1191601 ttaggagcaa aaggggtgaa ctcttgtacg gttacagcat gtgctacagg aacgaactcc 1191661 atcggtgacg cgtttaaggt tattcagcgc ggtgatgcag acgtgatggt cacaggcgga 1191721 acagaagcgc cgctgacaag aatgtcattc gccggcttta gtgccaacaa agcgctgtct 1191781 actaatccag atccgaaaac agcgagccgc ccgtttgata aaaaccgtga tggctttgtc 1191841 atgggggaag gtgcagggat tatcgttctt gaagaacttg agcatgccct ggcccgcggc 1191901 gctaaaattt acggagaaat tgtcggctac ggctcaaccg gagacgctta tcatatcaca 1191961 gcgccggccc aagacggtga aggcggagcg agagcgatgc aagaagccat taaagatgca 1192021 ggcattgcac ctgaagaaat tgattacatc aatgctcacg ggacaagcac gtattacaac 1192081 gacaaatacg aaacaatggc gattaagacc gtttttggcg agcatgcgca taaacttgcg 1192141 gtaagctcta caaaatcgat gacaggccac ctcttaggag cagccggcgg tattgaagcc 1192201 attttctcta tcctggccat taaagaaggc gtgattccgc cgacaatcaa tattcaaaca 1192261 cctgacgaag aatgtgattt ggattatgtg cctgatgaag cccgcagaca ggaacttaat 1192321 tatgttctca gcaactcatt aggattcggc ggacacaacg caacattaat ctttaaaaaa 1192381 tatcaatcat aatcaagcca aaccggctgc ccttaaaggg tagccggttt tttttgtgtg 1192441 cataggatta aaagaggagg cgatcacatg agtgtagaac aaacatatag ctggctcagg 1192501 aaggccggtt caatagatga tttggcgcat tacattatcc cgcttttttc aggtgcggag 1192561 aaaaagaact ggaagggcat tctggggcat cttcagcatc atgggatgtt taaaaacata 1192621 aaagagggta ttcagacggt ttccaagctg aaggaaaaag gtttttacgg acatatccaa 1192681 aaggaagaac agtacctcaa aaacaaatgg caaggtcctg atgtaccaat tgttacgctg 1192741 ccggttgatg aacgaaacag gagaatccgt ttagaattcg gatcaaaatc aggactcgcc 1192801 tttcaagaca aaatgttcct ttttctttcg tcagatttag attttgggtc ggtatctgcc 1192861 cttatgacgc atgagtatca tcacgtttgc cggttaggtc atctgacaaa agaggaaaag 1192921 gatgtcacat tacttgatac aatcatcatg gaagggctgg cggaatatgc tgtttatgag 1192981 aggttcggcc gaagtcaaac ggctgaatgg acgacttggt atacaccgga acagcttcag 1193041 gctttatatg aaaaaaagat tgcgccccat cgggatatca aacgggataa tcgattattt 1193101 ccccagctgt tattcggcaa aggatatcag ccaaaaatgc ttggatacgc agttggattc 1193161 aatattgtaa aaaaatattt aaccgccagc aaggcaagca ccgcagacgg gctgtccatt 1193221 cctgctgaga cctttttgga tgcaatgctt taaaaggata aaataatgga atttcattaa 1193281 taatattaca tttatcctaa aaaattcttg attttgcaaa atgattgtaa taatatacaa 1193341 ctataaaatt tttcgataat tcaatattat ttattatttc tgaataaagg gattgctttc 1193401 tcttgaaaac gtttgacaac aagagggggg aaaggggagc tagcatgagc acacttttag 1193461 aagtgaataa tttaaagact tattttttca ggaaaaagga gccgatccct gcggttgacg 1193521 gagtcgattt tcacatcagc aaaggcgaaa ccgtcgcgct tgtaggtgaa tcgggctccg 1193581 gaaaaagcat tacttcttta tcaattatgg gcctcgtcca aagctcaggc ggaaaaatca 1193641 tggacggctc tattaaactc gaagacaaag acctcacctc attcactgaa aacgattatt 1193701 gcaaaatccg cggtaacgaa gtatccatga tctttcagga accaatgacc tcccttaatc 1193761 cggtgttaac aatcggagaa caaattaccg aagtgctgat ttaccataaa aacatgaaga 1193821 aaaaagaagc ccgtcaacga gctgttgaac tcttgcagat ggtcggtttc tcccgggcgg 1193881 agcaaattat gaaggagtac ccgcatcggc tgtccggcgg tatgagacag agggtgatga 1193941 ttgccatcgc actgagctgt aatcctaaac tgctcattgc tgatgaacca acgacagcgc 1194001 tggacgtgac aatacaagcc caggtgctgg agctcatgaa agatctctgt cagaagttca 1194061 atacatcgat tcttctcatc acacacgact taggtgtcgt gtctgaagct gccgatagag 1194121 tgattgtcat gtactgcgga caagtcgtag aaaacgccac tgttgatgac ttatttttag 1194181 aaccgcttca tccgtataca gaaggcctgc ttacgtcaat tcctgttata gatggagaga 1194241 ttgataaatt aaatgcgatt aaaggcagtg tgcctacacc ggataatctg ccgccggggt 1194301 gccgttttgc cccaaggtgc ccgaaagcta tggataagtg ctggacaaat cagccttcgc 1194361 ttttgacaca caaaagcgga agaacggtga gatgcttttt atatgaggaa gagggtgccg 1194421 aacaatcatg acagcagcta atcaagaaac aatcttagag cttcgtgacg taaaaaaata 1194481 ctttccgatc cggtcaggcc tttttcaaag aaaagtcggt gatgtaaaag cggtggatgg 1194541 tgtttcattt tcgttaaaaa aaggagaaac actcggaatc gttggagagt cgggctgcgg 1194601 aaaatcgact gccggcagaa cgatgatcag actgtacaaa ccgacagagg gccaaattct 1194661 ttttaaaggg caggatattt ccaatctgtc agaggagaag ctgcggaaga gtgtccgcaa 1194721 aaatattcaa atggttttcc aagatccatt tgcttcgtta aacccgagaa agaccctgcg 1194781 ttccatcata aaggagccgt ttaatacgca caacatgtat accatgcgtg aacgaaacga 1194841 aaaagttgaa gagctgcttg caagagtagg gcttcacccg tcgtttgccg gccgttatcc 1194901 ccatgagttt tcaggcggcc agcgtcagcg gatcggcatt gccagagcac tcactttgaa 1194961 tccagagctg atcattgcag atgagccggt ttccgcactt gatgtatcca ttcaggccca 1195021 agtgattaac ttgatggagg aattacagga agaatttaat cttacgtatc tatttatctc 1195081 tcatgatctg agtgtcgtcc gccatatcag cgacagagtc ggagtaatgt atcttggcaa 1195141 aatgatggaa ctgaccggca agcatgagct ttatgacaac ccgcttcacc catataccca 1195201 agcgctttta tcctccgttc cggttacaag aaaaagaggt tctgtcaaac gtgaacgcat 1195261 tgtcctgaag ggagaactgc ctagtccggc caacccgcca aaaggctgcg tattccacac 1195321 aagatgtcct gttgcaaaac cgatatgcaa ggaacaaata ccagaattta aagaagctgc 1195381 tcccagccac tttgtggctt gtcaccttta tagctaatgt tgcccgcaca gctttgagag 1195441 ggggtatgca cactacataa acaacagcct agaagaacga acatttcaag agggggaata 1195501 tctaatgaaa agacggaaaa ccgcactgat gatgctaagt gtattgatgg ttctggccat 1195561 ctttttatca gcctgctcgg gatcaaaatc aagcaacagc agcgcgaaaa aatcagcagg 1195621 caaaccgcag caaggcgggg atttggttgt tggttcaatc ggagaaccca cactttttaa 1195681 ctctctgtat tctaccgatg acgcaagtac ggatattgaa aatatgctgt acagcttttt 1195741 aacgaaaacg gatgaaaaac taaatgtgaa attgtcactc gctgaaagca ttaaagaatt 1195801 agacggcggc cttgcatatg atgtgaaaat taaaaaaggc gttaagtttc atgacggaaa 1195861 agaactgact gcagacgacg tcgtatttac gtacagtgtc cctttaagca aagattacaa 1195921 gggagaacgc ggttcaacat atgaaatgct gaaatccgta gaaaaaaagg cgattacgaa 1195981 gtcttgttta agctgaaata taaagacggt aatttctaca acaatgcgtt agacagcaca 1196041 gctattctgc cgaaacatat tctcggtaat gttccgattg ctgatttaga agaaaatgag 1196101 tttaacagaa agaaaccaat cggttcagga ccatttaagt ttaaggaatg gaagcagggc 1196161 caatatatta agctcgaagc gaatgatgat tactttgaag gaagaccgta tttagatact 1196221 gtgacgtata aagtcattcc tgacgcaaat gctgccgttg ctcagctgca ggcaggcgat 1196281 attaatttct ttaatgtgcc cgccactgac tacaaaacgg ctgaaaaatt caacaaccta 1196341 aaaatcgtta ctgatttggc attaagttat gtgtacatcg ggtggaatga aaaaaatgaa 1196401 ttattcaagg ataaaaaggt tcgtcaagcg ctaacaaccg ctcttgaccg cgagtcaatc 1196461 gtcagccaag tattagatgg agacggcgag gtagcttaca ttccggaaag ccctttatct 1196521 tggaactatc ctaaagatat agatgttccg aaatttgagt acaacgagaa aaaagcgaaa 1196581 cagatgcttg cagaagccgg ctggaaagat acgaacggtg acggcattct ggataaagac 1196641 ggaaagaaat tctcgtttac ccttaaaacg aaccaaggaa acaaagtccg tgaagacatc 1196701 gctgtcgtcg ttcaggaaca gctgaaaaaa atcggcattg aagtgaaaac ccagatcgtt 1196761 gaatggagcg ctctcgttga acaaatgaat cctccgaatt gggattttga tgcaatggtc 1196821 atgggatgga gtttatccac attcccggat caatatgata ttttccattc aagccagatt 1196881 aaaaagggtt tgaactacgt ttggtataaa aatgccgaag cggataaact catgaaagat 1196941 gcaaaatcaa tcagtgacag aaagcagtat tcaaaagaat atgagcaaat ctatcaaaaa 1197001 attgcggaag atcagccgta tacgttcttg tattatccta acaaccatat ggcaatgccg 1197061 gaaaatcttg aaggatacaa atatcatccg aaacgtgatt tgtataatat tgaaaaatgg 1197121 tggcttgcaa aataaatttc ccttaaaggg gagggagagc gttttctccc tcttctgttt 1197181 ttaataagga aagtaaaggg ggacaagtat atggctgcat atattatcag aagaacctta 1197241 atgtctatcc cgattttatt gggaattacg attttatcat ttgttatcat gaaagccgcg 1197301 cccggagatc cgatgacatt aatgatggac ccgaaaatca gccaggctga cagagagcag 1197361 tttattgaaa aatacggtct gaatgatcct cagtacgttc aatatttaaa gtggctaggc 1197421 aacatggtgc agggtgattt cggaacgtct attgtcagaa aaggaacgcc tgtttcagaa 1197481 ttgattatgg caagactacc caatacgctc ctgctgatgc tggtttcaac gattttggct 1197541 cttatgattt ctattccgtt cggtgtcctg tcggcaaagc ggccgtattc aaaaatcgac 1197601 tatggcatta catttacctc gtttataggc ctggctattc caaacttttg gtttggatta 1197661 attttgatta tggtgttatc ggtaaatctc ggctggtttc caactggggg tgtcgagaca 1197721 ctgaataccg aattcaatat atttgaccgg attcatcatt taattctgcc tgcattcgtt 1197781 ctagctacag ctgacatggc cggactgacg agatacacga gatccaatat gcttgatgta 1197841 ttaaatcaag attatattcg cacagcgaga gcaaaaggat ttaaagagaa cagagtgcta 1197901 tttaaacatg gattgaggaa tgcattatta cccgtcatta caattttcgg tttgatgatt 1197961 ccttcattta tcggcggatc tgtcgttgtc gaacaaattt tcacttggcc gggattagga 1198021 aagctgtttg tcgattcagc attccagcgc gattatccgg ttatcatggc aatgactgtg 1198081 atctcggcgg ttcttgtcgt tgtcggaaac ctcattgcag acatccttta cgcgattgtt 1198141 gatccgcgga tcgaatatta aaaggaggga aacagagatg tcagagctgc aaacaactcc 1198201 ctcgccggag atcaggctga aagaaaatat ttcgaaaaag ccagaaacaa tgacaaagat 1198261 tttctgggaa aaattctcga aaaacaaact ggccatttta ggtgccgtta ttctttttat 1198321 cattattatg tctgctgttt tcgccccttt aattgcacct tatccccaag agcagcaaag 1198381 cctgcttgat aaatataagg cgccgggcct tgaacatctg atgggaacgg ataaatttgg 1198441 acgtgatatt ttcagccgga tcctatatgg agcgcgtgtc tctttattgg ttggatttgc 1198501 gtccgtagtc ggttcgattt tgatcggaac ggttttagga gcattagccg gatatttcag 1198561 aggaatagtg gatgctgtca ttatgcgtgt agttgacatt gtgttatcca ttcctgatat 1198621 tttcttgttg atcacgctgg tcaccatctt caagccgggt gtggacaaat tgattttaat 1198681 tttctgtctc acaggatgga ccacaacagc acgattagta aggggagaat tcttgtcgct 1198741 ccgttcaagg gaatatgttc ttgctgctaa aacaattgga acaaaaacgc acaaaattat 1198801 tttttctcat atcctgccca atgcgttagg gccgattatc gtgtcagcta cgctgaaagt 1198861 tgggtctgtt attctagctg aatcggcgct aagctacttg ggctttggaa tccagccgcc 1198921 aatcgctagc tgggggaaca tgcttcaaga cgcacagaat ttcacagtaa tgattcaagc 1198981 atggtggtac ccgttatttc ccgggctatt tattttaatg accgttttat gcttcaactt 1199041 tgtcggtgat ggcctgcggg atgcgcttga cccgaaaaat attaaataaa aatgaatatc 1199101 atatctgtta taaaatatca ccaaatcaga aaaaagcagg tctcctttag tcagaaaata 1199161 tacaaagaga tctgcttttt atgattctta cataaaccca gtgattccag atttcctcaa 1199221 tctctttgga ataatttctc tatcccttgc ctatactgtg gacaacagtt tttataaaag 1199281 tgaggggtta gagatgttat ttcttcatga tgtgtgggtc aattggtttg aaggggaaga 1199341 aaatggctac aatgtatgcc actttcacga atggcgcaag gaagatacgg ttgagctttt 1199401 ggatcaggtg ccgctgttaa gggtgccgtc agtactgttt cattacatag aaaacgattt 1199461 gtcagagctt ccgaaaggtt tgcttgaaga cgtacatcag aaatcgtaca ttcgaaaaaa 1199521 tcatgagcgg acaaagcttg agtattgttt tgtcgtaaca gacggaatcg gcattttagc 1199581 tgttgacacg atcggctaca cgatccctgt cagaaaaagc cgtctaatcc caagacagga 1199641 gcagctcgtt tatgaaatgg taaaagatgt agagcctgaa acatatgaat ttgagccaaa 1199701 gaagctggaa tcctccaagg aatatcacat cttatcatta gcaccagaac atgtcagagg 1199761 actgacaaga aaagaacggc aaattaagca gctgatgttt atggcgcttg accaattaaa 1199821 agggctgaaa aaccgagcgg aaattggcta ctggtacaca gagtggaatc cgcatatgta 1199881 tgaacaaatc aaaaggatga gctttgaaga gatttgggac atgctgtata acgaaacaat 1199941 tgaaggctgg tcggacaaac acctagcttt ttgcgaaaac ctaataaaag gacagccttt 1200001 tttcgaaaag ctttgggaaa tggaaaacga atcaaaggtc aactgaaaaa aaccgctctt 1200061 tgcaaagagc ggttttttga ttagcgtctt tttcttccaa gacccatggc attctccatt 1200121 tttttcagca ttttgtttgc tgtccgattc gctcgttccg cgccttcatc aagaatccgg 1200181 tctaattctt cagattctat cagctcgtaa tagcggtcct ggatcggttt taatgcgttc 1200241 actacgactt ctgccaaatc acctttaaac tcgccgtagc cttttccttc gtactttgct 1200301 tcaagctctt caattgtcgt attgccgagg attgaataaa ttgtaagaag gttggaaacg 1200361 cccggtttgt tttccttatc aaatttgaca atgccttcag aatccgttac tgcgcttttg 1200421 attttctttt caagctgctt cggctcatcc agcaatgtaa tataagcttt ctgattcgga 1200481 tcagatttgc tcattttctt cagcggatca ttcagagaca tgatacgtgc accgactttt 1200541 ggaattttca cttccggaat cgtaaagatg tcgttgtatt ttttgttgaa gcgttctgca 1200601 agattccgcg tcagctcaag gtgctgcttt tgatcctcgc cgacaggtac aagatccgtt 1200661 ccgtacagca gaatatcagc ggccatcagc ggcggatatg ttaacaggcc ggagacgaca 1200721 gcttcattgc ctttggattt gtccttaaat tgagtcatcc gctcaagctc gccgatatag 1200781 gcgacacact gcatcatcca tccggcctgc gcatgtgcgg ggacctctga ctgaataaac 1200841 aatgttgctt tttctggatc aagtccgaca gctaagtaaa gcgccgcgag attgcggata 1200901 ttctttctaa gctcaagccg gtcttgagga acagttatcg catgctgatc gacgatgcaa 1200961 aaatagctgt tataatcatg ctgcagttcg acaaactgct tcattgcacc gatatagttg 1201021 ccgagcgtca ctgagccgct tggctgaatg cctgaaaaaa tcgtttgttt catgaaaaca 1201081 tcaacctcat ttcttaaaac ataataaaaa aggctcattc ttcccctgta aaaaagggac 1201141 gaatgaaccg tggtaccacc ctgattattc cattaaaatg gaatcactct gacgtttgta 1201201 acggagactg ctccggctga gcctactttt ttccagttcg gtcagctgct ccaaagtcca 1201261 ttccacattg cccgttatct gctcccagca ccgcagactc tcttcaaaca ggtgaaacgt 1201321 gtactactct ttttcatagc aagcttttct tttgattgct tcattataaa tcaattataa 1201381 ccaattgtca tcatgaaaaa acattctttt ttccagtaaa attgtaataa tataaataac 1201441 acgagtgctg taaaatcctt aaatgataac tgctatcagc gtaaaaacag gcagatatta 1201501 tatgtaaaaa gcaatatggg cagaaaacac atgaaaaagt ttttaatcaa tttatgcttt 1201561 aaatggtaga aggatattat gttcatggaa gaaaaactaa cgaagtttaa atattttaaa 1201621 ttgataaaat aatattgcaa taaattattt gtttcattat aatgaacttg ttcactctat 1201681 tgttacagct tttttacaaa aataatcaga aaagacggaa cagaataaaa gttgtggaaa 1201741 ctcaggttca tttgtctgat atttctgagg atttagccgt aaggagctga aaattattat 1201801 tagggggttt gcgaatatga aaaaacgttg gtcgattgtc acgttgatgc tcattttcac 1201861 tctcgtgctg agcgcgtgcg gctttggcgg cagcggatca aacggtgaag ggaaaaagga 1201921 cagtaaagga aagacgacac ttaacattaa tattaaaact gagccgttct ccttacatcc 1201981 gggattggca aatgattcag tatcaggcgg tgttatccgt cagacttttg aaggattgac 1202041 acgtatcaat gcagatggtg agcctgaaga aggcatggct tctaaaattg aaacgagcaa 1202101 ggacggaaag acatatacat ttaccattcg tgatggtgtg aaatggtcta atggagaccc 1202161 tgtaactgca caagattttg aatatgcttg gaaatgggcg cttgacccta ataatgaatc 1202221 acaatacgct taccagctct actacataaa aggtgctgaa gcggcgaata ccggaaaagg 1202281 cagcctagac gatgtggcag taaaagctgt gaatgacaaa acgctgaagg ttgaattaaa 1202341 taacccgact ccatatttca ctgaattaac tgcgttctat acgtatatgc cgatcaataa 1202401 gaaaattgca gagaaaaata aaaagtggaa tacaaatgcc ggagatgatt atgtatcaaa 1202461 cgggccgttc aaaatgacgg catggaaaca cagcggctct attactctcg aaaaaaatga 1202521 ccagtattgg gataaagaca aagtcaaact gaagaaaatc gatatggtta tgatcaacaa 1202581 taacaatacg gaactaaaaa aattccaagc tggcgaactt gattgggccg gtatgccgct 1202641 cggacagctt ccgacagaat ccctgccgac cctgaaaaaa gacggttctt tacatgttga 1202701 gccgattgca ggagtgtatt ggtacaaatt caacactgaa gctaagccat tagacaacgt 1202761 caatatccgt aaagctttaa catattcgct tgaccgtcag tcgattgtta aaaacgttac 1202821 gcaaggagag caaatcccgg caatggctgc agtgccgcct acaatgaagg gatttgagga 1202881 taacaaagaa ggatacttca aagacaatga tgtcaaaaca gcaaaagaat accttgaaaa 1202941 aggcctaaaa gaaatgggct taagcaaggc atctgatttg ccaaaaatca aattgtctta 1203001 caacactgat gacgcacacg cgaaaatcgc tcaagcagta caagaaatgt ggaagaaaaa 1203061 tttaggcgtt gatgttgagc ttgataactc agagtggaat gtctatattg ataagctcca 1203121 cagccaagat tatcaaatcg gccgtatggg ctggctcggc gacttcaatg atcctatcaa 1203181 cttccttgaa ttgttccgcg acaaaaacgg aggaaataac gatacaggct gggaaaatcc 1203241 agaattcaaa aagcttctga atcagtcaca aactgaaaca gataaaacaa aacgtgcaga 1203301 gctgctgaaa aaagcagaag gtattttcat tgatgaaatg ccggttgccc caatctattt 1203361 ctatactgat acttgggtac aggatgaaaa cctaaaaggt gttatcatgc caggtactgg 1203421 tgaggtttat ttcagaaacg catattttaa ataaggctac gtctgaaaat aaaagacctc 1203481 aaggtatatg gggagaaaag ccccatatac ctttcttact gatggagtat aaaaatgtaa 1203541 aaaccatgga ggtgttcccc cttgctaaaa tatatcggaa gacgcttagt ctatatgatt 1203601 atcacactat ttgtgattgt aactgtgaca ttcttcttaa tgcaagcagc accgggcggg 1203661 ccattttcag gtgagaaaaa gcttccgcct gaaattgaag caaatttaaa tgcgcattat 1203721 ggcttggaca agccgctgtt tgtacaatat gtcagttatt tgaaatcagt tgcaatgtgg 1203781 gatttcggac cgtcatttaa atataaaggt cagagtgtta acgacctgat cagttcaggt 1203841 ttccccgttt catttactct tggagcagaa gctattctcc tcgctttagc gttaggtgta 1203901 ttgtttgggg tcattgcagc cctttaccat aataagtggc aggattatac cgtcgcgatt 1203961 ttaacgatat ttggtatttc ggttccgagc tttatcatgg cggctgttct gcaatatgtg 1204021 ttctccatga agcttgggct gtttccggtc gcggggtggg attcctgggc atacaccttt 1204081 ttgccttcca tcgcacttgc ttccatgccg atggcgttta ttgccagact ttcccgttca 1204141 agcatgatcg aagtgttaaa cagtgattat atccgcacag cgaaagcgaa agggctttcc 1204201 cgcccagcgg ttacagtgcg gcacgccatt cgaaacgcac ttttgccggt tgttacatat 1204261 atgggcccga tggccgcaca ggtcttaacg gggagcttca ttattgaaac catttttggg 1204321 attccggggc ttggtgcaca cttcgtcaac agtattacaa accgtgatta tacggtcatt 1204381 atgggtgtaa cggtgttctt cagtgtcatc ttgctattgt gtgtattaat cgtagatgtg 1204441 ttatacggca ttattgatcc aagaatcaag ctttccaaag caaagaaagg agcctaggcc 1204501 atgcagaaca ttccaaaaaa catgtttgaa ccagccgcag cgaatgccgg cgatgcagaa 1204561 aaaataagta aaaagagcct ttccctctgg aaagatgcga tgcttcgctt ccgcagcaat 1204621 aagcttgcaa tggtcgggct tatcattatc gtacttatta tccttatggc aatttttgcg 1204681 ccgatgttct caaggtatga ttattcaact actaatctct taaatgcgga taagccgcct 1204741 tcaaaagatc actggttcgg aacagatgat cttggacggg acattttcgt ccgtacatgg 1204801 gtaggggcgc gaatctcaat ctttatcggt gttgcagctg ctgttctcga tttgctgatc 1204861 ggcgtcattt gggggagcat ttcaggcttc cgcggaggaa gaacagatga aatcatgatg 1204921 cgtatcgctg atatcctttg ggcagttcct tcattattaa tggttatctt actgatggtt 1204981 gttcttccga aaggtctatt tacgattatt attgccatga cgattacagg ctggattaat 1205041 atggccagaa tcgtgcgcgg acaagtgctg cagctgaaga atcaggagta tgtgcttgct 1205101 tcacagacac tgggtgcaaa aacatcccgt cttctattta aacatatcgt gccaaacgca 1205161 atgggttcta ttttggtcac gatgacactg acagttccta ctgcgatttt tacagaagcc 1205221 tttttaagct atttgggact tggtgttccg gctccgctgg caagctgggg aacgatggct 1205281 tctgacggat tgcctgcatt gacctattat ccgtggcgtt tattcttccc tgccggattt 1205341 atctgcatta caatgtttgg ttttaacgtt gtcggcgacg gattaagaga cgcattggat 1205401 cctaagttac gtaaataagg gagtgatacg ggtgacacgc ctattagaag taaaagattt 1205461 agcaatttca tttaaaacat atggcggaga ggtccaggcg atccgcggag tgaatttcca 1205521 tctggataaa ggggagacgc tggccattgt tggagaatca ggttccggaa aaagtgtaac 1205581 ctctcaagcg attatgaagc tgattccaat gcctccgggt tatttcaaac gcggtgagat 1205641 cctgtttgaa ggaaaggatc tggtgccgct gtccgaaaaa gaaatgcaaa atgtccgggg 1205701 aaaagagatc ggcatgatat tccaagatcc gatgacctct ttaaatccaa cgatgaaggt 1205761 cggtaaacaa attacggaag tgctttttaa acacgaaaag atctcgaagg aagcggctaa 1205821 aaaacgcgcg gttgaactgc tggaattagt cggtatccca atgccggaaa agcgggtgaa 1205881 ccaatttccg catgaatttt caggcgggat gagacagagg gttgtcattg ccatggcgct 1205941 tgcagcgaat ccgaaacttc tgatcgccga tgagccgaca actgctcttg atgtaacgat 1206001 tcaagcgcaa attttggaat taatgaagga tttgcaaaag aaaattgaca cgtccatcat 1206061 ctttatcaca cacgatcttg gtgttgtggc taacgttgct gaccgggtcg ctgtcatgta 1206121 cgcgggacag attgtagaaa ctggtacggt agacgaaatc ttctacgacc cgagacatcc 1206181 gtacacttgg gggcttcttg catccatgcc gacactggaa agttcaggag aggaagagct 1206241 gactgcaatt ccgggcacgc cgcctgattt gacaaacccg ccaaaaggag atgcttttgc 1206301 cctgcggagc tcttacgcga tgaaaatcga ttttgaacag gagccgccaa tgtttaaggt 1206361 atccgatact cattatgtaa aatcgtggct gcttcatcct gacgcgccaa aggtagagcc 1206421 gcctgaagcg gtaaaagcga aaatgcgtaa actggcaaac acgtttgaaa aacctgtctt 1206481 agtgagagaa gttgaatgaa ttgactgaaa aactattaga aatcaaacat ttaaaacagc 1206541 actttgtcac gccgagggga acggttaagg ctgtagatga tttatcattt gatatctata 1206601 aaggtgaaac attagggctg gttggtgaat ctggctgcgg taaatcgaca acaggccgaa 1206661 gcattatcag gctgtacgaa gcaaccgatg gtgaggtgct gttcaacggc gaaaatgtgc 1206721 acgggagaaa atcgcggaaa aagctgctgg aattcaaccg caaaatgcag atgattttcc 1206781 aagaccccta tgcatccctg aatccgagaa tgacagttgc tgatattatt gctgaaggcc 1206841 ttgatattca taagctggca aaaacgaaaa aagagcggat gcagcgagtt catgaactat 1206901 tggaaacagt gggattgaac aaggaacacg cgaaccgcta tcctcatgaa ttttccggcg 1206961 gccagcgcca aagaatcggg attgccagag cgcttgctgt tgatccggaa ttcattatcg 1207021 cggatgagcc gatttccgct ttggatgtat ccattcaagc gcaggtcgtg aatttaatga 1207081 aagaactgca aaaagaaaaa gggctcacat acctgtttat tgcccacgat ttatcgatgg 1207141 tcaaatacat cagtgaccgc attggcgtca tgtatttcgg gaaactggtt gagcttgcgc 1207201 cggcagatga gctttatgaa aatccgcttc acccatatac aaaatcattg ctttctgcga 1207261 ttccgcttcc tgatccggac tatgagagaa atcgcgttcg ccagaaatat gatccgtctg 1207321 tccatcaatt aaaggatggg gaaacgatgg aattccgtga agtcaaaccg ggacattttg 1207381 tgatgtgcac ggaagccgaa tttaaagctt tttcatgatt catcaatcct tcaagagatt 1207441 tctcttgaag gatttttttg cgtcttcata gaaagtgaga atgataacat ttacaattag 1207501 aggaaaaagc ggaggcgaaa tacgattcaa tttctgcata acaaaaatgt ttttgcgcta 1207561 ttgctgtctc aatcttttca atctttagca ggagtcctcg tcacaatcgt tttaatggtc 1207621 cggatctatc aaatgactga ctccgttttt ttggcgggcc ttattttatc gttcatgtcg 1207681 tttgcgagta tagcagcaag cttttgcgtc tctccggtgc ttcgcattct cggttttaaa 1207741 aaggtgcttg cgggagcgaa tctgctgaga gcggtcttta ttatactgat ggcatacagc 1207801 gtcactcatc acggacaggc attcttttgg attacgctgc tgtttgtgtt ttgtttttcc 1207861 ttcgcgggcg ctttttttca gccggcaaga tttgcgctgc tgccgattat tgttccaaag 1207921 aagcaatatg taaaagcgaa tggtgtgatc tccctctcga atcaattgtt cttaacagca 1207981 ggctggggcc ttggaggcct tctgacgtac gccgtccctt ttgaactcgt tgtcggcgct 1208041 gccatttgcc tgtttgttct atcgggagct tccatcagtg tgctgcatgt aaatgaagaa 1208101 gaggctgcag gaactgctga aacagcatct gtcagaagta tatggaagga tttaatgatc 1208161 atccctattg taagagacat tactgtaatg gacatgttag aagctttggc gggttccgta 1208221 tggtcatctg ctattctcct cgcatttact gcggctgttt tgcatgaaac agaggtgtgg 1208281 tgggggatgt ttaacgcttc ctattttata ggcgcaattg tcggcagtgt gattgctatt 1208341 cgtttttctt ctttttttga gcggaatatg ggctatgcca ttatgttcag ctcgcttgta 1208401 atgtcggcgc tgaccctttt gttttcattt tctccagtcc catttttatg cgctctggct 1208461 tgtgctgcaa tggggccttt ttatcaggtg cgtgatattt gccaggaaac catgctgcag 1208521 gaagttattc ccgagcagaa acgaatcgga atcatggctg caaaaaatgc gattttgact 1208581 ccttggtcag gcgtcaccta ctccattatg gggctagtgg ctgatgctgc tggtgcgaaa 1208641 atagctttta tcgcggctgc tgcattatat atcatgacat ttctgattgc actggcgcag 1208701 ccccgtctgg ttcattacag gcgagaaaat cgagttcaat gagaaacact tcaaaatgaa 1208761 cggagcagct ggctccgttt tgctgaaaaa aaaatgaaac catggcggaa gttcgcacgt 1208821 ctttatagat gtaaggctgt ttaaacaaga agaaatgggg tatatctaaa agtatgaaga 1208881 caacgaactc ataaggagca aatcaatgaa ctggtatgaa aagcttagcg agtactttcc 1208941 aattgaagaa atgaaatcaa aagcgcatat ggaagctctt ctgaaagagc gaagcgatat 1209001 ttatcataaa gatgaaggca aacatcatat tttaatgttt gcggaattcg attcttttat 1209061 cttcgttgat tatctgtatg tgtctaagga tgcaagaggg caggggcttg gcggcaaatt 1209121 gatcgcgaag ctgaaaaaga aaaataagcc catattgctc gaggtggaac ctgtggatga 1209181 agatgatact gatacagaaa aacgcctgag gttttatcaa agagagcatt tcaagcatgc 1209241 tcagtcaatt gggtaccggc gccggtcatt ggctacgaat gaagtaaaca agatggagat 1209301 tctgtactgg tcaccaaaaa cagaatcaga agaagaaatt cttgaagcca tgaaacagac 1209361 atatgaaaac attcatactt ataaagatga gaaatggtac ggagaatcgt acgaaaaaac 1209421 ggatgaggtc ttggaaatca tcgatgaaga aaaacaaaaa aatattttcg atcagttaag 1209481 ctaattgaga ataagaacat atcatgaaca ttaaaaattt gctggattga cacatttttt 1209541 tcttaggata ctgttcacac ttactttttt atagtataat acctgtaaag attccttttt 1209601 tagagtaatt tcaatttaag aataaaatag atgttcatcc tactaattag aggagtgaag 1209661 atgaatggtt acactataca catcaccaag ctgtacttca tgcagaaagg cgagagcgtg 1209721 gctcgaggag cacgagattc catttgtaga aagaaacatt ttctctgaac ctttatcaat 1209781 tgatgaaata aaacaaattc ttcgaatgac tgaggacgga acagatgaaa tcatctcaac 1209841 ccgttcaaaa gtattccaaa aactgaatgt gaacgttgaa tctatgccgc tgcaagattt 1209901 gtaccgcttg atcaacgagc atccaggttt gcttcgccgt ccgatcatca ttgacgaaaa 1209961 acgtttgcag gtcggatata acgaagacga aatcagacgt ttcctgccaa gaaaagttcg 1210021 ctctttccaa ttaagagaag cacagcgttt ggcaaactaa tagatcgtat catcaaaaga 1210081 aggctgagtc atcagccttc ttttattttt caacctgctg gtaataaatg ctcgcaagga 1210141 tgacaaacgc aaccgtcaaa atggggagga gcgtttcgac tgtgccgtgc tgcgccataa 1210201 aaagcgacag ctttttgtct ctgacaatca tttctccgcc agtataagca agcagcccgc 1210261 ttcccgcgta aatcagaagc ggtattttct ctagtgcaat atggatgagt ttgctgcccc 1210321 aaataataac cggaaccgat acacacaatc ctataacaac gagagaaaac tcaccgtgtg 1210381 aagctcccgc aactgcgatg acgttgtcca gcgacataaa gagatctgca agcacaatcg 1210441 ttcgtatcgc tctccacagg gaggtgctgc ttttaatgtg tttcgtgtct tttttttcaa 1210501 tcagcagctg atatcctaaa tacagcagga aaattccgcc ggcgcactgc aagaacggaa 1210561 tgttcaaaag atatactgct gcacttgtta atccgattct catggcaacg gcaataaatg 1210621 ttccgagaat aatggcttgc tgtctttgct tgtccggcaa atgtctgctg gccatggcaa 1210681 taacaaccgc gttatctccg ccgaggatca ggtcaatccc aacaatgacg agcagagaaa 1210741 tcagatagtc atgctccatg aagcggcacc tcgctttcag tccttcgctt gtactactac 1210801 tatatgagac aggtcatatt ttatgatatc agccgcctga tctgccgttt tttaggcaaa 1210861 ggtgcatttt tatttctttt gtgactgttt tatcataaaa tagaaataca aaggaattca 1210921 cactggcctt ggttaaggtt aagatgtgga cggaatgggt aaagtgtagt aaagtacaat 1210981 taatcgggag cttagatgtc ccttcaacat cttatataga agggaaggtt ggcaaatgga 1211041 aattgaaaga attaacgagc atacagtaaa attttatatg tcttacggag atattgaaga 1211101 tcgcggtttt gacagagaag aaatttggta taaccgtgag cgcagtgaag aacttttctg 1211161 ggaagtcatg gatgaagttc atgaagaaga ggaattcgct gtggaaggcc cactttggat 1211221 tcaagttcag gcactggaca aaggattaga aatcatcgtc acaaaagccc agctttccaa 1211281 agacggacaa aagctcgaac tgccgattcc tgaggataaa aagcaagaac cagcatctga 1211341 ggatcttgac gccttgctgg atgatttcca gaaagaagag caagccgtca atcaggaaga 1211401 gaaggagcaa aagcttcaat ttgtcttgcg atttggcgat tttgaggatg ttatttctct 1211461 atctaaattg aacgttaacg gaagcaaaac gactttatat tcgtttgaga accgatatta 1211521 tttatatgta gatttttgca atatgactga tgaagaggtt gaaaatcagc taagcatcct 1211581 gctggagtac gcaactgaat cctcaatcag catacaccgt cttgaagagt acggcaagct 1211641 gattatttca gagcatgctc tagaaacgat aaaaaaacac tttgcatcat agcaaaccga 1211701 tttccttccg gaaatcggtt ttttttatgc acgaaaatgc cattttagag atgtgaaaaa 1211761 tcaaaaacat atagacaagc agaaaataca gcgaacagga gttgatcatc ttttccagaa 1211821 agtatacttc atctggaaag gagagatgac aattgtttag tgctgtgact gaagacggcc 1211881 aaatgtttca ccttctaggc gctcagcaaa accagaaatt aaagcggaga cggttcttct 1211941 gtccggtatg cgggggagag ctagctgtga agctcggact tcaaaaagcg ccgcattttg 1212001 cccataaaca gaacaagtcc tgcgccatag acatcgagcc ggaaagcgcc taccacttag 1212061 aaggaaaaag acagctgtat gtatggctga aaacgcaacg ggcttcacca atattggagc 1212121 cgtatataag gacaatcaac caaagaccgg acgtcatggc aagaatcaag gagcatatgc 1212181 ttgctgttga atatcaatgc gccactatcg ctccagatgt ctttcaaaag cggacagagg 1212241 gcttcaaaca agaaggaatc atcccgcagt ggattatggg atacagccgc ttaaaacgga 1212301 ctgcttcgtc cttttatcag ctttcaactt ttcattggca gtttatcaat gcaagtccat 1212361 acagagaact gatatgttat tgtcctgaaa ggcgttcttt tctccggctc agccacatca 1212421 ttccattcta cacaaaccat tcttattcct cagtccaaac gatccctatc catcgggcag 1212481 gtgcaggcga tctttttttc actgaaccga aaccctcaat tcaatattca ggctggacga 1212541 aagcgattca ccgttttcgc cataaacccc atcggtttaa ctcaaaggaa acaaatcgcc 1212601 ttaggctgct gttttatgag aaacgacaga cgcctttttc ttttctgccg actgaagtgt 1212661 ttgttcctgt tagaaaaggg gcagttttta agagtccggt ttttgtgtgg caggggtttc 1212721 tttatttgtt tatgacggat cttggaggta aacgtgcgcc aattcgtttt tcagccgttt 1212781 tgcagcagtg caaactgcac attcataata agaacattgc actcaggtcc gaatgcagcg 1212841 aagagtgtct ttcagaagcg gttaaacagt atattgattt tttgtgcaag aagggatttt 1212901 taagggagac tcagaaagaa gtatatgtgc tgaatcagcc tgcaggaggc atacactcca 1212961 tgcaggatct catagaaaga gaccgcagct gttttataga atgagtttgt cttatttggc 1213021 tcaccctaag acaaaggtgg tgggcaggct gtgaaaggca caaaaggaaa ggtttttcgt 1213081 gtttttactg cttttttggc attcgttctc ttcattactg catatgattt gacaaaaggc 1213141 agtgaaaaac cggaagatat tcacaacaca agtttattga gaaacagctg ttttttcaat 1213201 tggcttgaat caaagaagac gagggggatc accatggctg aggaaaaaaa agcaaaccaa 1213261 ctgcctgaca gaagtgaggt aaaggcagaa gacacatgga gacttgagga tatttttcct 1213321 agtgatgagg cctggaataa agaatttcaa gctgtaaaag aattaattcc gaatttatct 1213381 aagtataaag gaaagctggc agattcagct gatcatttat acgaggctct tacgtatcaa 1213441 gataaagtga tggagcggct aggtaggctg tacacatatg cgcatatgcg ctctgaccag 1213501 gatactggga actcctttta ccaggggctg aatgacaagg cgggaaacct gtatacacag 1213561 gccgcaagcg cgacagctta tttggttccg gagattttat ccatagaaga agacaaactg 1213621 cagcagttca ttcttgaaaa agaagaattg aagctgtact ctcatgcgat tgaggagatt 1213681 acaaaggaac gtccgcatgt gctgagcgag aaggaagagg cgctgcttgc tgaagcctcc 1213741 gaggtactgg ggtcatcttc aaatacattc agcgtgttaa ataacgcaga tataacgttt 1213801 ccatccatta aagacgaaga tgggaatgaa aaacagatca ctcacggcaa ctttattaat 1213861 ttcttggaaa gtgaaaaccg tgaagtccgc aaaaatgcgt ttgacgcagt gtataaaacg 1213921 tacggacaat ataaaaacac aatggccacg acgctaagcg gcactgtgaa aaaggacaac 1213981 ttctacgcga gagtgaaaaa gtacaagtcc gcgcgtgagg ctgcgctttc taacaacagt 1214041 attcctgagg aagtatacga taaccttgtt aagacgatta ataagcattt gccgctcctg 1214101 caccgctata ttgcgctaag aaagaaagtg cttgagcttg atgaagtgca tatctatgac 1214161 ctgtatacac cgcttgtgaa agatgctggg atgaaggtga catacgagga agccaaagat 1214221 tacatgctga aaggcctcgc acctttaggg gaagaatatg cctctatcct aaaagaagga 1214281 ctggaaaacc gctgggtgga cgtttacgaa aataaaggca aacgcaatgg ggcttattca 1214341 tcaggagctt acggcacgaa tccgtatatt ttgatgaact ggcataataa cgtcaataat 1214401 ctctttacgc tcgtgcacga gtttggacat tccgtacaca gctactatac gagaaagcac 1214461 cagccttatc catacggcaa ttacagcatc tttgtcgcgg aagttgcctc tacgacaaat 1214521 gaagcgctcc ttggcgaata tttgctgaac aatttagagg atgaaaaaca gcgcttatat 1214581 attctcaacc atatgcttga gggcttcagg ggaacggtct tcagacaaac gatgttcgct 1214641 gaatttgaac atctgattca tacaaaggcg caagaaggcg agccgcttac acctgagctt 1214701 ctgacaaatg tctattacga cctgaataaa aagtattttg gagacggcat ggtgattgat 1214761 aaggaaatcg gccttgaatg gtcgcgtatt ccgcacttct attacaatta ctatgtgtat 1214821 cagtatgcga caggttacag cgctgcccaa gcattaagca gccagatttt gaaggaagga 1214881 aagccggcgg ttgaccgtta tattgacttc ctgaaagcgg gaagctcaca atacccgatt 1214941 gatgtcctga aaaaagcggg tgttgatatg acgtctccag agccaatcga agccgcgtgc 1215001 aaaatgtttg aagaaaaact tgatgaaatg gaagagctgc tgatgaaagt caagcagtct 1215061 taaaaaagta agcctgtgcg gaaatgacgc acaggctttt ttaaaaccct ttaaaggttt 1215121 tccggtgatt caagcggtag agggtaaaca aaatagacag aaacagcaga ggagaggtaa 1215181 tataaagcgg cagcatatgc atcatgccta agatattcaa gcagaaaaaa acagcaatgc 1215241 acacaattga gatcaaagta gacatcatgg cggtcctcct cgtccttttt ccttataagg 1215301 atatgagtga atgcacttcg ttatgttttg tgacaaaaat atgaacatta agcatagagg 1215361 ttgtcaaaag tcgacatctt ttgttatcat aaggatgtga aattgatcac aaacaaacat 1215421 tacccctttg tttgaccgtg aaaaatttct cccatcccct ttgttgtcgt taagacatat 1215481 gaaaccgcgc ttatcccggc gcggtttctt tagtgctaaa aatggaacgt acgtttggtt 1215541 atggcataaa aaaacagcct caagcatatg cacgcctgcg gctatttttc acatgattga 1215601 tattcatcag aataagtgct gagagacttc caaaacattc cgtgtttggc ttccactttg 1215661 gcaacctttt tagcaaacgc cagttttttc atttcttttt ctacctcttc aaggctcagg 1215721 tcatatacaa gagcaatttc cttcgaggca acgaagcgga aatattcaat aaaacattct 1215781 aaaggcggtg tttccgacgg cttcggctcg tcgccaagca tctcaaataa aatttcttca 1215841 tatacatcat atgagtagct gccaggaact ttaagccctt catcctcatg ctgcgtatta 1215901 aaaaacgtca gtgtcggatt aacagaaaca tccatctcgg cagcaatttt catgtcacat 1215961 tgaagcgcct tgaccgcgct ttgagaatgc agatcttttt tgaattcttc aagatcgaga 1216021 cttgtatttt cagcaatctc caaaagcacg ttttcatccg taatattttt ctttgaaaca 1216081 aataggctct cctgcatatt tctgagaaat tgcatgccgg cttttcgtcc ttgcagttcg 1216141 gctgctttaa aagcgagagc agccatataa ggcgatgaaa gcggctgatc ctgttcgaac 1216201 cagacattgc cgtcacatga catgccagag cggctcgcga tcttttccca tgcttctgcg 1216261 agaagatgct tttttcgctt tttatttaaa gcggtaaggc ttgcggaagc gataatgcgt 1216321 aaggtgaaaa aacgtccgta tctgattttc agctttttga tgacgggctc taaggaccag 1216381 cattcaggac ataaagggtc tacaaacata taaatttcaa gcggtttttt tggatgaccg 1216441 tggcaatggg cgaagtatag ctcatgctga tagtttgtca agatgatcga tcctccgctt 1216501 ccgtttgatt caccatatgc cttgctgtca actccagccg gccaaacaaa aactcacgaa 1216561 tttcgccctc cagccctaca tggtccattg cgtccttcat acagctgagc cacgcatcag 1216621 ctctctcgtt tgtaattgga aagggaagat gccttgctct gagcatagga tggccgtgtt 1216681 cctcagtata aagaggaggc ccgcctaaat actgagttaa gaattgcttc tgtttcctgg 1216741 cggtttctgt caaatcgctt ggaaaaatcg gcttcagcaa aggatgagac gcgacacgct 1216801 cataaaaagt atcaacaagt tgcgatagaa gttcctctcc aatcgcttca taaggtgcgt 1216861 taaacgattg tcccatgttg actactcctt taaatatggc taataggaat cataaatcct 1216921 attgcaaaaa gtaattttct gtatttcatt gtttcatcta gatttatttt agcaacaagg 1216981 catcatttct acaaacaaac tgccttttat gcgtttgatg actcatttcg gctgacagcc 1217041 ggggtttgta tttcatatca tatcacataa aaatcaggaa tgcgtaagat ttcacttcgc 1217101 aaaaaaacca gagggaaaga gcacctctgg ttacgcgtaa taaactgaag ttattttttt 1217161 tacatagttt tgcgtttctt ggaaaggagg aatgcctccg tatcggtcaa cattccccgg 1217221 tccggcgttg taagccgcta atgccataga cacattgccg tcgtatttat ccagcatttg 1217281 ttttaaatat ttcgttccgc cctccacatt ttgctgcgga tcaagcggat tggaaacgcc 1217341 aagtgagctt gctgttgacg gcatcagctg catgaggccc atcgcacctg ctccgctgac 1217401 cgcttttgca ttaaagcctg attcctgttt gatgacggcg cggatcagtt tttcatcaac 1217461 gccatattta tcagcggctt ttttaatcgc actgtcaata gagaagtctc ccgaacggat 1217521 ctgatttgct tcatgtttgt ttgaagctga atctgcaaca gctgtttcag tgctttctgc 1217581 cgcttttgtg actgaacctg aattgctgct cgtatatgag ttaagcccat acgctgaaag 1217641 cagtgacggc gctgttgtat tcgcgctgtt cagcatgctg agcgggcttg gcgatgaaga 1217701 aggtgctgat tgctgagatg tcagaccgtt tgtatattgg ctgagcaaag aactgaaact 1217761 tgaaagcggg ctttccgtat tctgagtgtc cgagctgctg cgtgcattag atatggactg 1217821 taatgcctga agctgaagta atgctgccca attcgttaca ttcacgatgt cattccacct 1217881 tatatagact ttcgtttttc ttcataaaaa cgcagaattt tatttttggt ttcgcgctga 1217941 ggaatgctga attgctgaag cagcttttcg aaggcttgtc tgccctcatg ccaatccgcc 1218001 gcctcaaatt caatttcata gtcctcttta tttaaatatc ggctgtggtc taaaactatt 1218061 aagccttttt ctgtttcttt ttccgcacgg tttgttgcta aagatccaaa gtattgtatg 1218121 gcatccgtat cgatctgaag cttgtgcagc tggtccttca cagggccctc gggaactgaa 1218181 aatccagcga gatctgatac ctctgaaagc tgctggtgcg tttccagaag ccccacatca 1218241 gccggctcct ttaatgtaag gacatacttt ccgttttttc tgcggatacg aagcgcagca 1218301 tgtttttgtt tcagcgcgaa gctgtctgta tcaaaataat gattcttttg atctgtaaaa 1218361 tctttttctg tcagctggag tgccgatgct atgtttttga attcttgttt ggtcagcatg 1218421 tttttaaatt cgatttcaat ctcttggctc atgatgctct tcctttccgc cctgtaaatc 1218481 ttatttttac tattatctct ttagatgtta ggtttatcaa tatcgagctc gatatgataa 1218541 aatgaatctg tactttgttt aaaaaaggag agcattatgc aaaacagaat cgaaattttg 1218601 aatgcaacat tatcggatga tcagcttcgc cttgcctgtc agacagaagg aaacgaagcg 1218661 gaacgcaagc cgtcaggtca aatgcttgtt gattctgacc actttgcttt tgtatacata 1218721 cttgaattag ctgattcttt tgaatatgtc attataaagg aacatgtatg gccggaactg 1218781 aagcaggccc atgcacaaaa aataccggtt gttttagagg caggagacca aacaattgaa 1218841 ctggcaggcc tgcatgagga gctggaatat cttttagaaa atataaaaga taatgcaaac 1218901 tatggagaag aaatggaaga aaaagtgaaa cgcgtgtttt tatagaaact ggttcggaat 1218961 tgggggatgt atgatggatg acaaacaatg ggagcgtttt ttagtgccgt accgccaggc 1219021 tgtcgaagag ttgaaagtga agctcaaggg gatccgcaca ctatatgaat acgaggacga 1219081 ccattcaccg atcgaatttg tgaccggacg cgtcaagcct gtggcgagca tacttgaaaa 1219141 agcgagacgg aaaagcatac cgctgcatga aattgaaacc atgcaggaca ttgctggcct 1219201 tagaatcatg tgccaatttg tcgatgacat ccaaatcgta aaagagatgc tttttgccag 1219261 aaaagatttc accgttgtgg atcagaggga ttatattgcg gaacataaag agagcggata 1219321 ccgatcatac catcttgttg tgctgtaccc tttgcagacg gtatccggag aaaagcatgt 1219381 tctcgtagaa atacagatcc gtacactggc gatgaatttt tgggcgacca ttgaacattc 1219441 attgaattat aaatacagcg gaaacattcc tgaaaaagta aaactaaggc ttcagcgcgc 1219501 ttctgaagcg gcttcccggc ttgatgaaga gatgtcggag atcaggggtg aagtacagga 1219561 agctcaagct gccttttcaa gaaagaaaaa aggaagcgag caacaatagg taaaggggaa 1219621 gaagagcatg aaatttgccg tatcatcaaa aggagatcaa gtttctgata cgctgaaaag 1219681 caaaatacag gcgtatttat tggattttga tatggaactg gatgaaaatg aaccggaaat 1219741 cgttatttca gtcggaggcg acggaacgct tttgtatgct tttcacagat acagcgaccg 1219801 tttggacaaa acagcatttg tcggcgttca cacaggtcat ctgggttttt atgccgactg 1219861 ggttcctcat gaaattgaaa aacttgttct tgccatcgcg aaaacgccgt atcatacagt 1219921 cgaatatccg cttctcgaag tcattgtgac ctatcacgaa aacgagcggg aagaaagata 1219981 cttagctttg aatgaatgta cgattaaaag catcgaagga agccttgttg ctgatgtgga 1220041 aatcaaaggg cagctctttg aaaccttccg gggcgacggc ctctgcctgt caactccatc 1220101 aggcagcaca gcctacaata aggcgctggg cggagcgatt atccatccgt ctatcagggc 1220161 gatccagctt gcggaaatgg cttcaattaa taaccgcgtg ttccgtacgg tcgggtcacc 1220221 tctgcttctc ccatcccatc atgattgcat gattaagccg agaaacgaag ttgactttca 1220281 agtgacgatt gaccatttaa cccttctcca taaggatgta aagtcgatcc gctgccaagt 1220341 tgcatccgaa aaagtgcggt ttgcgagatt ccgtccgttt ccattttgga aaagagtcca 1220401 ggattcgttt attggaaaag gtgaatagaa agaggacata tcgtggagca tttttttatc 1220461 agaaagaaca ttacttccgc tgaggacggg atgactgtaa aagaatatgc cggtgaactg 1220521 ggaatttcga aacgtctgct gaccgatatt aagtttggcg ggggagacct gcagattaac 1220581 ggtgagcatg tgacggtcaa atacgttttg aaagagggag atcttcttat cgtgaagttt 1220641 cctgaggagc aggtgagcga gacgctgttg gcagagcctg ttccgctcga tatcctttat 1220701 gaggatgaac atgtgcttgt gataaacaag cagccgtatg tgtcatcaat cccttcgaga 1220761 gagcacccct ccggcagcat tgccaatgga attattgatc attatcaaac aaccggagtg 1220821 agggcgacag ttcatcttgt cacccggtta gaccgggata catcaggtat catgcttgtt 1220881 gccaagcatc gatttgccca ctccatttta tcgtctgcgc aaaaaaacgg ccttgtgaaa 1220941 cgccggtatg cggcagtggt tcacgggcgg atggcacaga tggagggaac agtcgatgct 1221001 ccgattggca gacatcctga cagtattatt gaacggacgg taacgccaga cggccagaag 1221061 gctgttactc atttttacgt cacatgtgca aatgatgaca tgacctcggt ggcattgcag 1221121 cttgagactg gacgaaccca tcaaattcgt gttcatatga gctatctcgg gcacccgttg 1221181 tgcggcgata cactgtacgg cggaacgaga caggaaattg gccggcaggc tctgcacagc 1221241 gagcatcttt cgtttatcca tccgctgaca caggagaaca tgaggtttca tgctccactg 1221301 cctcaggaca tgagcaaact gataaaagga gagaatcatt gattctctcc ttttttatat 1221361 ggggcgaaat cttgattcgt cgtaaggcag ggagcttgga acagagacgg tttctatttc 1221421 tggaaagcga aagcctgtca gttgatttcc gaacacgcag cctgtatcaa tgttgatggt 1221481 gcgattgacc ttccgaggct ctttcacagg tgtatgaccg tataccaccc aagcctttcc 1221541 gttataggct gccgcccaat cacgcctgat gggtctgccg tccggatatg tttcacccgt 1221601 cacgtcaccg taaagcacaa agtccttcac tctgcgggta tatttgccga tatcgtcagc 1221661 tcttatgcca gcatgggcga caactaattc tccattatgt aagatgtcgt aaagcggcgc 1221721 tgtttcgtac agcttcataa actgttcgct gactgatttt ttctcatctt tggaaagttc 1221781 ctcaagctct gccgctgttg tttcgagacc atgcatcact tttaccggat ttccttttaa 1221841 gtaacgatat aatttattgc aatggtttcc cgggacataa cgcacagcgc ctttttcgta 1221901 agcgccggct acaaatcgga tgacctctat cgatttgggc cctctgtcag ttaaatctcc 1221961 ggcaaaaaca agcaccctgc cttcttcatg gacaggtact ccatttttga ttgtatagcc 1222021 aagcttttgg attaatgcag tcatttcgtc atagcagcca tgaatatcgc tgatgatatc 1222081 gtaagccatg cggtctcctc cttaccgatt gttttattta ttatgaagca aagtgttgtg 1222141 agtcatcaca agcttttatg tgcaaattat agaagaagaa tcattttcta aacaggatta 1222201 agaccttatc actttatttt tcatcatcac ccttgttaaa atcgcgttat gttttttaaa 1222261 aatgaggttt tgttctctga gtgagaacta gcataaccct gacttaaaaa ggaggttctg 1222321 attatggcgc atacatctgt cgcatcttta gttgttgtac ttatcgttgc atttttgaca 1222381 cccatccttt tgcatcggtt taaactcagc atcccggttg ttgttgctga aatcattatg 1222441 gggctgataa ttgggaaaag cggccttaat ttagttgtgg agggtgacac ctggctccag 1222501 acactctcta tgctcggatt tatcttttta atgtttttaa gcgggcttga aattgatttt 1222561 tcgtcgtttg agaaaggaaa gaaaaagcag ttcctgccga atggcaagga agcgccgaat 1222621 acgtttgctg cggcatctgt tattttcgtc ggtattttta ttttatcatt gctcttgtcc 1222681 tatgggttcg tcttggccgg atttatccaa aatgcatttt tgatgaccct gattatttca 1222741 acgatttcat taggcgttgt cgttccaaca ttaaaagaag aacggatcat gaattcgaat 1222801 atcgggcaga ttattttgct tgttgctgtt attgctgatt tggccacgat gattcttctt 1222861 gctgtttttt cttctttata cggagaggac agcggaaaca tgtggctcct gatgattctg 1222921 tttgcggccg gagtggtgct ttactttttc ggccgggtct tcaaacatcg ctcttttgtt 1222981 caatccatgt caaaagggac gatccagatc gggacgcgtg ccatttttac gttaatcatt 1223041 gtactcgttg ccctgtctga atcacttggg gcggaaaata ttctcggcgc tttcttagcg 1223101 ggggttcttg tttccctgct ttcgccaaac aaagaacttg ttcagcagct ggactcattc 1223161 ggttatgggt tcttaatacc gattttcttc gtgatggtcg gtgtgaagct tgatatttgg 1223221 actcttttcc aggataaaac aattttaatc atgattccgc tcctgctgct tgcgctgtta 1223281 gtcagcaaaa tcattcctgt catgtactta aagaagtggt atgataaccg aaccattttc 1223341 gcgtctggtt tcctgctgac atcaacgctt tcgctcgtga ttgctgctgc aacaatcggc 1223401 cagcagcttc acgtgatcag tacaaatatg tcaggagcgc taattttagt agccgtcatt 1223461 gcaagtattt ttacgccgat ctgttttaaa aaattataca aacgggaaga gcagccggag 1223521 gagaaaaaga cgattacgtt cattggcgcc aatcaaatga ctttgcctgt cacactcgaa 1223581 ttgccagagg aagagtatga cgtgcgtgtt gtacacgtct accaagagaa tgcggaggaa 1223641 aagctgtcag aatcagtgtt tgctgttgaa acaatttctg actatgaaca cgagacgctt 1223701 gaatcactcg gcatttttga aacggatatc ctcgttgtgg cgacaggaaa tgaagatatg 1223761 aatgcagaca ttgcattact tgcaaaagat aaaggcacag aaagagtcat tgcaagcgta 1223821 ggatcaccgg agcatgaagc agctctgaag gagcagggaa tcagcatctt ttctattctg 1223881 ctgtcgacaa aaacgctgct tcgcgcactg attgaagcgc ctggcgtcat gaagctgctc 1223941 acgaaccaag agtcttcgct gtatcaaatt aatatggaga acagtaaata tgatggtgtc 1224001 attttacggg aattcccttt aacaggtgac gtcatctttg tcaggatctt cagaggtgtg 1224061 gacagcatcg ttcctcatgg ggatacgagg ctgaaacttg gagaccgttt aattgtcacc 1224121 ggatctcggg ggtacgtaac ggatcttaag aaaacattgg aaggataaat cttgaccaaa 1224181 taaggattcg tgttaatata gaggtgcaga acaattcaat atgtattcgt ttaaccacta 1224241 ggggtgtcct tcataagggc tgagataaaa gtgtgacttt tagaccctca taacttgaac 1224301 aggttcagac ctgcgtaggg aagtggagcg gtatttgtgt tattttacta tgccaattcc 1224361 aaaccacttt tccttgcggg aaagtggttt ttttattttc agagggggaa tgatttgtga 1224421 agttttcaga agaatgccgc agtgcagccg cagaatggtg ggaggggagc tttgtccatc 1224481 cgttcgttca aggaatcggt gacggaacgc ttccgattga ccgttttaaa tactacgtac 1224541 ttcaggattc ctattattta acgcattttg caaaggtgca gtcatttggt gccgcttatg 1224601 cgaaggatct ttatacaacg gggcggatgg caagccatgc ccaaggtaca tatgaggcgg 1224661 aaatggcgct tcatcgcgag tttgccgagc tgttggaaat cagcgaggaa gagcgtaagg 1224721 cgtttaagcc gtctcctacg gcgtactctt atacatccca tatgtaccgt tcggttttga 1224781 gcgggaattt cgcagaaatc ttagcggccc tgctgccatg ctattggctc tattacgagg 1224841 ttggtgagaa attgctgcat tgtgatccgg ggcatccaat ttatcagaag tggattggca 1224901 catatggcgg tgattggttt agacaacagg tcgaggagca aatcaaccgc tttgatgagc 1224961 tggcggaaaa cagcacggag gaagtgcgtg ccaagatgaa agagaatttt gtcatctcca 1225021 gctactatga atatcaattt tggggaatgg cctatcgaaa agaaggctgg tctgacagcg 1225081 ccataaaaga ggtggaggaa tgtggagctt cacgccataa cggatgacag caagccggta 1225141 gaagagctag cgagaatcat cattacgatt cagaatgaag ttgattttat tcacattcgg 1225201 gaacgctcaa aatcggcggc ggatattttg aaactgctcg atcttatttt tgaaggcggt 1225261 atagataaac gaaaattggt gatgaacggg cgcgtggata ttgcactttt ctctactatt 1225321 caccgcgtgc agctgccaag cggcagcttt tcaccgaagc agatcagagc cagatttcca 1225381 caccttcata tcgggaggtc ggtgcattca ctggaggaag cggttcaagc agaaaaggaa 1225441 gacgcggact acgtgctgtt cggccatgtg tttgaaacgg attgcaaaaa gggtcttgaa 1225501 ggcagaggag tatctttgct gtcagatatc aaacagcgga tttccatccc ggttatagcc 1225561 atcgggggga tgacgccgga caggttaaga gacgtaaaac aagcaggggc agacggcatt 1225621 gctgttatgt caggaatttt ctcttccgct gaacctttgg aagcagccag acgatattcc 1225681 cgcaagctaa aggagatgcg ctatgaaaag gcattatgaa gcagtggtga ttggaggcgg 1225741 aattatcggt tccgcaattg cttattattt ggcaaaggaa aacaaaaaca ccgcattgtt 1225801 tgaaagcgga acaatgggcg gcagaacgac aagtgccgct gccggaatgc tgggcgccca 1225861 tgccgaatgc gaggaacgtg acgcgttttt tgatttcgct atgcacagtc agcgtctgta 1225921 caaaggtctt ggagaagagc tttatgcatt atccggtgtg gatatcaggc agcataacgg 1225981 cggtatgttt aagcttgcat tttctgaaga agatgtgctg cagctgagac agatggacga 1226041 tttggactct gtcagctggt attcaaaaga agaggtgtta gaaaaagagc cgtatgcgtc 1226101 tggtgacatc tttggtgcat cttttattca ggatgatgtg catgtggagc cttattttgt 1226161 ttgcaaggca tatgtgaaag cagcaaaaat gcttggggcg gagatttttg agcatacgcc 1226221 cgtcctgcat gtcgaacgtg acggtgaagc cctgttcatc aagaccccta gcggagacgt 1226281 atgggctaat catgttgtcg ttgccagcgg ggtgtggagc ggaatgtttt ttaaacagct 1226341 tggactgaac aatgcttttc tccctgtaaa aggggagtgc ctgtccgttt ggaatgatga 1226401 tatcccgctg acaaaaacgc tttaccatga tcactgctat atcgtaccga gaaaaagcgg 1226461 aagactggtt gtcggcgcga caatgaagcc gggggactgg agtgaaacac cggatcttgg 1226521 cggattggaa tctgttatga aaaaagcaaa aacgatgctg ccggctatac agaatatgaa 1226581 ggtggatcgt ttttgggcgg gactccgtcc gggaacaaag gatggaaaac cgtacatcgg 1226641 cagacatcct gaggacagcc gtattttatt tgcggctggc catttcagaa acgggatcct 1226701 gcttgctccc gcaacgggcg ctttgatcag tgatctcatc atgaataaag aggtcaacca 1226761 agactggctg cacgcattcc gaattgatcg caaggaggcg gttcagatat gatgctacag 1226821 ctgaacggta aagacgtgaa gtggaaaaaa gacacaggta caattcaaga cctgctggcg 1226881 tcgtatcagc ttgaaaataa aatcgttatc gtggaaagaa ataaagaaat aatcgggaaa 1226941 gaacgctatc acgaggttga gctttgtgat cgtgatgtca ttgaaattgt ccattttgta 1227001 ggaggcggat gagcatgtta acaattggcg gaaaatcatt tcaatcaaga ttgctgctgg 1227061 gcacggggaa atacccatcg tttgacattc aaaaggaagc agtagctgtt tctgagtctg 1227121 atattttaac atttgctgta aggagaatga acatttttga agcatctcag ccgaattttc 1227181 tggaacagct tgatttatcc aaatatacgc ttttgccgaa tacagcgggc gccagtactg 1227241 ctgaagaagc ggttcggatt gcaaggctgg cgaaagcttc aggcctttgt gacatgatta 1227301 aagttgaagt catcggatgc agccgttcct tgctgcctga ccctgttgag acattaaaag 1227361 cgtctgaaca gcttcttgaa gaaggcttta ttgtgctccc gtacacgtcg gatgacgttg 1227421 tgctggcgag aaagctggaa gagctcggcg ttcatgccat catgccgggt gcatctccga 1227481 ttggatcagg acaaggaatc ttaaatcctt tgaatctgtc gtttattatt gaacaggcga 1227541 aagtaccggt catcgtggat gcgggaatcg gctcgcctaa agatgcggca tacgcaatgg 1227601 agcttggagc ggatggcgta ctgctcaata cggctgtatc tggcgctgac gatcccgtga 1227661 aaatggctcg tgccatgaag ctcgcagtgg aagcagggcg cctttcttat gaggcgggcc 1227721 gaatcccgct taagcaatac ggaacggcaa gcagtccggg agaaggtctt cctgtatgac 1227781 aggcaggtat tcaaggcagg agctgtttgc tccgatcggc ccatccggcc agaaaaaatt 1227841 gaaagaagcg cgcgccgtga ttatcggcgc cggcgcgctc ggaacagcca gtgcagaaat 1227901 gctggtgaga gcgggagtcg gctctgtgaa aattgccgac agagattatg ttgaatggag 1227961 caacctccag cgccagcagc tttatacaga agatgatgtc aaaaaagaaa tgccgaaagc 1228021 agccgctgcg gagcgccgtc tccgttcgat taacagcgat gttgatgtga ccggccttgt 1228081 catggatgtg acagcagaaa atatcttcga gctgattagg gatgcatcga ttattgtgga 1228141 tgcggctgat aattttgaaa cccgcctgat cgtaaatgat gctgcggtaa aggaagggat 1228201 tccttttctt tacggtgcct gtgtagggag ctacggtctt acctttaccg tggtgccggg 1228261 ttctactcct tgcctgcatt gcttgctcga tgcacttccg attggcggag caacatgtga 1228321 cacagctggc atcatcagtc cggctgtttt gcaggtagca gtctttcagg taacagatgc 1228381 actgaaactg ctgacgggag aggagtgcga gccggtgctg cgctcctttg atttgtggaa 1228441 aaacgagcgg tcagaagtga gagcggccag tctcaaacat gacgcatgcc caagctgcgg 1228501 cacaaaggat tttccgtttt tgtcttatga aaatcaaaca aaagcggctg tattgtgcgg 1228561 caggaacacg gtgcagatca gatcatctat tacgaaagaa gcggatcttg aagcgcttgc 1228621 cggtcagctg aggcaggccg ggcttgaagt agctgcgaac ccgtatttaa tttcctgccg 1228681 ctcggatgat atgaaaatgg tgctgttccg ggacggcaga gctttgatcc atggaacaaa 1228741 tgatattgcc cgggcaaaat ccatttatca taaatggatt gggtaataaa aggagtgtag 1228801 tgtaatgagt atatataaag cattgacaat cgccggatca gattcaggcg gcggcgcagg 1228861 gatacaggct gatattaaaa cctttcaaga gcttgatgta ttcggaatgt ctgcgattac 1228921 ggcggtaacc gctcaaaata cgcttggcgt tcacggggtg catccgctga ctgtagagac 1228981 gttgagacag caaattgacg ctgttgctga ggatttgaga ccggatgcag ttaagacggg 1229041 aatgctctgg aatgccgaca tgattgaaga agtggcaaga aaaattgacg agtacggatt 1229101 caatcgtgta attgttgatc cggttatgat cgcaaagggc ggggcatcct tgctgcgtga 1229161 tgagtcagtt gccaccttaa aggagttgct cattccaaga agctacgcga ttacgccgaa 1229221 tgtcccggaa gcagaaacgc tgacaggaat gacaatcagc tcgctggatg accggaaaaa 1229281 agcagcggag cagctcgtca agatgggtgc gcagcatgtc attatcaaag gcgggcacca 1229341 gcctgaggac aatcacatta ctgaccttct ttttgatggc agcatgttta tgcaaatcac 1229401 ccatccttat atcaatacga agcatacgca tggcacaggc tgcacctttg ctgcggcttt 1229461 aacggcccaa acggctaaag gagacagcat ccatcaggca tttgaggttg cggccaactt 1229521 tgtccgtgaa gcggtggaaa atacgctcgg catcggatcg ggacacgggc cgacaaacca 1229581 tttcgctttt aaacgaaaca gcttaaatac aagccgatga gatcaccagc tgatggtgat 1229641 ctcttttgcg tttgctacgg tatgcgcttt tcatctggac aaggttatga tatgatagga 1229701 attaagatca ggtactaata ctatgtcttt attaaatata ggaggcttta tacatatgaa 1229761 tttttcactt gaaggccgta acattgttgt gatgggggta gccaacaaac gcagcatcgc 1229821 ctggggcatt gcgcgttctt tacatgaagc gggtgcacgt ttgattttca catacgctgg 1229881 tgaacgcctg gagaaatccg ttcacgagct tgccggaaca ttagaccgca acgattccat 1229941 catcctccct tgcgatgtta caaacgacgc agaaatcgaa acttgcttcg caagcattaa 1230001 ggagcaggtc ggtgtaatcc acggtatcgc gcattgtatc gcgtttgcca acaaagaaga 1230061 gcttgtcggc gagtacttaa acacaaatcg tgacggcttc cttttggctc ataacatcag 1230121 ctcatattct ctgactgctg ttgtcaaagc ggcacgtccg atgatgactg aaggcggaag 1230181 cattgtcact ttgacgtacc ttggcggaga gcttgtgatg ccaaactaca acgtcatggg 1230241 tgtagcaaaa gcttctcttg atgcaagtgt gaaatattta gctgctgact taggaaaaga 1230301 aaatatccgc gtcaacagca tttctgccgg cccgatcaga acattatctg ctaaaggcat 1230361 cagcgatttc aactctatct taaaagacat cgaagagcgt gcaccgcttc gccgcacgac 1230421 aacacctgaa gaagtgggcg atacagctgc gttcttgttc agcgatatgt cccgcgggat 1230481 tacaggtgaa aatcttcacg ttgattctgg tttccatatc actgcccgct aagcaggatc 1230541 tatatcaagc aatcccgaat agggattgct tttttatttc ttctgatttt cagctttctg 1230601 tcatatagat agaatatgac acaatcggag ggatgaagat gtctaataag aaaagaaacg 1230661 cggataaaaa accgctcatg tatattgttc agccggatta tgcagaaact acaaggtcat 1230721 ccatgcagga gattgtcatc aaaagaaagg ccgacaaacc cgctccgcca aaagctgagg 1230781 aaaagccggc ttaccatgag aagcagcagg aggaagccgt ggcacaggat gtcctgcaag 1230841 aagaccaaaa gcctgcagcc gaaccagtga gtcagcaaac acaagaggcg agagagccag 1230901 agaacataaa aagccaagag gaacagaagg cagagccgca ggccgtagaa gaaaccgttg 1230961 aacacgagcc cccgaaagca gaaaaaaagg aagagcctgc acttgaggcc cggaagcctg 1231021 agaaagaacc ggaagctgtc catagtgctg ataaagcgga ggaaaaagca ccgccggcac 1231081 gaaaagtgaa aaaaccgatg agcaagatga cgatccacga aaaaattgat tttttaacaa 1231141 agctgcctca taacatgccg agagcgcttt gtttgattga agccaatgga agaacgtaca 1231201 ggggcgtgat tgtcggaaga agaaatgatt ccgtcctgct tcgaacaacc ggaaacggag 1231261 ccccaaccga actggcaatc gatgatatta cctctttgca cccgctcggt ttttaacgaa 1231321 aaagaaaaaa gctgcccggc tgatgttgcc ggacagcttt ttttacatag agaaaagcct 1231381 gcaggcctgc aagcttttcc agcttatgat taatgatgat gtgtacgatt gattaatcga 1231441 ggatttaagc agttgattgc gcagaagcag tctaagtcaa cttcaataca gtagttcgtt 1231501 ttttcgagtc ggaacacttc acacaccgta tctttatcgg tgaagtccaa aatgtgtttg 1231561 tgttcgtcaa atgcgattaa taatgacagt gttgcacagc ttccatgcac tctttcgacc 1231621 ctgaaaaata ctgtattaaa gcaagggccg ttatcgagtt cgccgacatt tccgaaggcg 1231681 actaatggcg ttgattttga tgtaaatatt gcaaaaggca ctgtgtcgcc taacgaatgg 1231741 cttacagata aaagcttaga gtggcagccg gtcgggcagt cttcttcaac agcgttttgc 1231801 agatcttcaa tattttctac agcttcacgc acgcagcttg atgttttctg gctcatatta 1231861 tccctcctgc cttataaatt tgagactggc gaaatgatgg agagtcagct gcctcacgct 1231921 ggaagcagct gaatgatttg cacctgtaat agagtttgga aggggattcc tctttacaag 1231981 tgtttatcca ttgtgatgat gctttttatc tttgtgaggc gatgttctgt caactagctc 1232041 tggtgacagg cactgaatcg cgcagaagca tccgagatcc acttcaatgc agaaatctgt 1232101 tttttctagc ccgaagaaat ccgggtcgca agggtggcaa acacttaagg tatcgccttt 1232161 gacatcgacc gggcgtaaaa tagacagtgt tgcacagcaa tcgcataatt tttcgacgcg 1232221 gaagaaaatg gattcaaagc attgcatatc atccacaaat ccccctacgt ttccgaatgt 1232281 ggagaacaat ccgccttttt tatcaaaaac gagaaacgga attgtgtctt ttccagcaat 1232341 cgtagggttt aaaaggttgg tatagcagcc agtcggacac tgttcttcaa ctgcctcctg 1232401 ctctgctaaa atcttttcca ctgcatcgca tacacagttc tcatgccggc catgggtttt 1232461 tccgcagctc attgatttca gctccttctt tatagggtat ttgactttag tccttaacaa 1232521 catatgtacc cgtgccccac ttggtgtggg tgaacgtcta tatattcatc atatgcttgg 1232581 aaaataagaa aaagcagagc gtttttagct ctgcttttag gtcctagagg acaagagtga 1232641 taactaggat ggctacgagt gtatttgttg ctgtagaaat aagggttgcg atatcggcat 1232701 ctactgttgt gacgtttacg ccgcgggaac attcgatgag aagtttttgg cggtttactt 1232761 gtttgttagc tgtaagctgt aacaaatctt gtgcgactaa ttcggcaatt acgccgtctg 1232821 caattgatgt cagagttgcc gttacgacag cggcattaag tgctgttaca actgatgtta 1232881 cggcttgaac gtctgtagat gtaacattga tgtcacaaga atctctaata ataatcgttt 1232941 catctgaaac ttgtttgttg agatttgctt gagctagatc ttggtcgatg aaggcgttgt 1233001 cgttgccaaa aaaaccattg ccattacagc aaacgtcgca atgacatttt ctttcgtgtt 1233061 tttctttatc tttctctttg tcatctaacg gatggtcaca gtcaggatca agtgcaaccc 1233121 aagaatatgg tctgctttcc atatctattc ctccttttct tttactgtta ttaaatgagc 1233181 gagcctctta ttttgactga gtcatatatc ctgatgaaga accctatttt ttatgattgg 1233241 ctaattgtta tcgtttttcc gtctttgtct gatctgttca atgagctgct ctctgcggct 1233301 taacggtttt gtgttctttt gctcttgtgc ggctgcttct tcttttttct tcttttggtt 1233361 ttctattagc gcttgtgatt tagcttgtaa gtcttttaca agatttaaga gcatttcttt 1233421 ttcttcgtct gatacttttt tcattttgtc ttttgtgacc ccatgtttag aaaatatatt 1233481 ttggaccagc attttcgtca ttggatcaac ttctggaagc tttgcaagct cttctttgaa 1233541 tttatcgtta tctgacattt gttttcacct cgtcttttaa gtttgtgaaa agaaagggtt 1233601 aaaggacgtc aagttcacta agaatgctgt ttaacacctg aagcaagatt tgtacaaagg 1233661 ttattatctc gtcggcagac aaagtaattt tgatgttgcg gctgttgata attttaatga 1233721 tggttctttt tttgatttgg gagctatcga gaataagaat ttcacttgcc actgcgtcag 1233781 ccaaatcctc gtcggcgatg acgagctgag tcgccacgat aatcatggtt gtcacaaagg 1233841 cttgtataga aagggcagct gttatatgtg acgtgtcaat tgtgatattt tcgcaatcaa 1233901 tcacttcgat ctgctgttcg aattcgcttg ataattgctc aaatattgca gggtgcaggg 1233961 attcgacttt ttcttcaaat gacataacct tcactccttt cttatccata ctctatataa 1234021 tgcaaatggg gtgcagagcg gaataataaa aataaccaat tttctgccgg acaagataca 1234081 attcatgaag aatagggttt tggcatatat gtgaagggat catgattggc aaaggagtga 1234141 acgagtggtt ataaatgggc tgacaattgt tcttctatcg cttgcggtct ttcggctcgc 1234201 ccgcctgctg gtgtttgaca cgattatggc gccgcttcgc agtctgtttc atgaagagaa 1234261 ggaagaaaag gatgcggacg ggaacattga aacctatatc gtgattaagg gaaccggtgt 1234321 cagggcgttt attggtgaat tgctgagctg ctattggtgc acaggcgtgt ggtgtgccgg 1234381 ctttttgatt ttatgccagg cggtgatccc gcaagcggcg cagtggctga ttttactttt 1234441 ggcgatcgcc ggccttgccg gcattataga aacgctcgta tcaaaatggc tgcaagaata 1234501 aggcgttacc accagcaact ttctgtcaga atacgcataa agtagcatat atgacataag 1234561 gaaaggaagg ggacaaaaat gaatcagcat cataaacctt cccaaaaatc tccatataca 1234621 gattcatcgt atcaatcaaa aaagataaaa aagaaaggct gcgggtgcgg aaataaaaag 1234681 aaaaagcctc aatagcctgg caaagaaacc ggagaactcc ggttttttgt ttttttaacg 1234741 aggcggtctc gctcagcata tatcataagc ggggggataa aagtgaatga gtttgaaaaa 1234801 tggatagaag gaagatatga accacatgaa caaaagcaaa aagagcatga agacacgatg 1234861 ggcagtatca gaaaagactt ggatgcattt gataaagccg gtctggaatt tgaagatgag 1234921 attgaagagc tggctgaaaa aacggaggcc ttacttaaaa aacatcaagc tcaatatgat 1234981 caatcgtaaa tccgcaaacg ccctatgcga atatccaagc cgatcccagc agctcacata 1235041 gtgtatagag agtaaaggag gtgcttatct atgggctttg gatacggatt cggcggcggc 1235101 tacggcggcg gctgttatgg cggttatgct ggcggttacg gcggcggcta tggttcaaca 1235161 tttgttttgt tggtcgtatt attcattctc ctcatcatcg taggtgcatc tttcttttaa 1235221 gatgtattga ggaagtacgg gttataaccc gtacttcctt gccttgtgtt tatttttaaa 1235281 aatgttggaa aagcacattg tattatgtgc attcatacaa taccgtatta ctccgccaaa 1235341 aggaggcgca ttatggataa tcaatttttt aagaacatcg aaaagaaaac aggtgtgaag 1235401 atgcaggatg taatgaatct tgccggatca ctccaaaacg ctaattttaa agatgaaaat 1235461 acagtgcgca gtgtgattaa ccgcgtagcg cagatggcaa acagacgcgt gccaaaagaa 1235521 ttagaagata aaattgtgga atctattaca agcggaaaag aaaagcttga ttttggcacg 1235581 atttctaaaa tgatggataa taaataagtg gatggcctgg ctgactcact gcagcgggcc 1235641 tttttttaca gtaaaaaccc ggcagtaatc tgccgggctg ttaatgatgc aagggctgtc 1235701 ttgctttctg tagcagggga tacaaaaatc ttgagcggtt ggctgttttg ccgcgcctgt 1235761 tagcagggca agacaaatat aaatgctgtt tcgcccgggt catggctaca tataaaaggc 1235821 gtctttcctc ctcaagagcg gcctcgtctc cttttcttgc cgtttctaat gagaaatcgt 1235881 gcggaatcga gccatctaca gtgcctaaca cgtagactgt tttgaattca aggccttttg 1235941 accggtgaat ggtcatcagc tgaacgccat gttcatccgt tctgtttttc tcagcggccc 1236001 tcatatggtc tacgtgggca agaaagtcag gaatcgtttt gaacttcttg gcgacaacct 1236061 tgatgtcgcg caggtcatca gagccttttt ccagcttgtt gccctcattg ccccgctttt 1236121 ttaaatactc ggagaagccc atttttcctt ctgcaaaggt gatggcttct acgggtttca 1236181 ttgtgcggag gcttgcaaaa aacggtacga ttttcttgat tttgtccagc tggaatggct 1236241 tcagatcagg caatttggcc agcgctttga tcatggtaca gtcctctgta atcgagagcg 1236301 ccttcagcgt attcaaagcg gactgtttta aaaacaaggc gggaagcaag tgtttaatcg 1236361 cctcggtgtc atcctcattt tggctggcgt acaagtaggc gagaatctgg cggacgatcc 1236421 gtctgctgta aaacgattgg acgccgcggt cagctgtata cggaattgac gattgatgaa 1236481 gcctttcata tatagcacgg cctccgctgt ttgtgcggta aagaaccgca aagtcttctg 1236541 gactggctcc attttgaatt ttttctttga tatcggaaac gaccattgtg gcttcttcct 1236601 cttcatcata aggataaaac agcacaggga cctgaatgtc atcgcgggcc gcttcaagcg 1236661 ttttggcata tctgtttttg ttctttttca caacgatatc agcactagag acgatcgggt 1236721 gcgtagacct gtagttcgca gttaaataga tcgtcttcgc tcccggataa tccttttgaa 1236781 aatcaagaat gaaagacgga ttgcttccgc gaaacgcgta gatggactgg tcatcgtctc 1236841 cgacacagca caggttttgc tccgggctgg cgagcatttg catgattttg tattgaaccg 1236901 gattaatgtc ctgaaactca tcaattaaga tatacgtaaa ccgagattga tattgttcca 1236961 gaaggtcagg ccgctcgata aacaattcat agcaggctga agccatgtca tcaaaatcaa 1237021 attggctgtg ttcttttttc tggcgttcat aatgttcata taaacgataa acttgttttt 1237081 cccactcatc ttttagaggg atgcgttcat ttgggacata agtgtttttc caaaaaccga 1237141 tctgctgcag ggcttggtca actggggatt ctttctcatc gatgccttct tcatagagtg 1237201 cttttttgat atattgttcc cgctgccact ccattttcag cagatgctca ccgttccatt 1237261 tagcagaatt agagtgatac aagatcttat aaaacagact gtggaatgtt cctgtcacaa 1237321 ttcttctgac ttttgccggc tgtaatccgt actggttcgc catacgctct ttcatttcag 1237381 cgacagcttt tgttgtaaag gtgacaagca gcatattttc aggcggtatg cctaagtgtt 1237441 cgatcatgtg ggcggcacgg gctgtcagta cccgtgtttt tccgctcccc gcacctgcaa 1237501 gcacgaggag cgggccctct gtttccgtga cagctttcag ctgatccgtg tttaaaccga 1237561 cagacggaaa aaggctcgta tcgggttcta ttgtttttgg cacaaatggt gttcctggtt 1237621 taatgcttct aggacggtgc cattctgtaa cagctgggga cgggtcagcg gcgatcgctt 1237681 ttcccttggg taaacgaatg acaccagatt cctgatcatc ttcttttttc ccctctttag 1237741 agggcttcgg ttcgcacgcc tcctcacatg ccggaaaatc gcctggctgg cgatggataa 1237801 actctggcgg atcggcgatg ttaagccgta acaaaacggg ctttccgcaa tgagaacaaa 1237861 ataaatgtcc ttttattccc tcttcaaaga ggaattgata atgttctctc gaatatgtat 1237921 gtaaatgtat gattctatca ttcagtcggg cgcatttcaa aaaggggtcc tcccaatcaa 1237981 aaggtgttca ttacagacaa tgactatcat atcaaaagaa atgtgtttca aaaagtaagt 1238041 ttaagggaaa agagacagca gaggggtggg tattgtatga tatatgcagg tcaaattcag 1238101 aaccagcaat acgctcaata tgctaataga acgattggac ataagcagga ttatgccgga 1238161 accgaaaaaa tcagctatgt cccgtttcag cgggtataca aagaactgga aaagcagcag 1238221 gagaatcaaa cggcagctga aagaaaagta aacgagatga aacgtaagcg ctctctttat 1238281 aagagattgc gagaaaaagg aatggggaca tatattaatc gatatgtata aaaaaccgtt 1238341 cataccagag aacggttttt ttatatgcag taaaaatccg gatctcaaaa gatccggatg 1238401 cgttcagtcc ttcatcattt gtaagtgcgg aatgccggca tcgaggaatt ctttttcaga 1238461 aagcacgcga tacccgtgtt tcttgtaaaa cggcacagcc tgtgtttgcg cgtttaaaat 1238521 gaaaccggaa gcgcctccgt ctgccgcggc tttttcgagc gctttcataa tgatgccgcc 1238581 gacaccggct gagcggtggc ttttcagtac gcaaatccgc tctaacttgc cgtagccgtc 1238641 cttcatgcgc catcttccgg caccgacagg cttttcaccg tcatacacga cgatatgctc 1238701 tgactcattt tcaagttcgt caatttcttc ttcagcaggc acgttttgtt ctttgacaaa 1238761 gacttcttct cttacataga atgcatcttt cagttgttct tcattttttg cgataactgc 1238821 tttcaaacat tattctcctc tgcctagcaa gaaggtttca tatactgtcc acgatccgtt 1238881 ttccaactgg tagagcaagt ggaaacggtc aacgatttct tcatgcgaca cttcctgcat 1238941 ttttaattgt cccagcacat ctgaatgctc atcgtcggaa agattttggc cgaccgtcac 1239001 atgcggaacg aaattatatt cctgttctcc tgccaacaca ccggtgtata gcttttcatt 1239061 gagtgttttt aactcttccg tcggttctgc tttgatgtaa atgacattat tgacaggcgc 1239121 aaatgagctg tattttgtca ttttgagaac gagtgggtgg gactcttttg cgatgtttct 1239181 taaatgtgat acgagctgat ccgctttctc ctccgcgcat tcaaaggatg ctctcagcgt 1239241 caaatgaggc gggattagag agtagcttgg gtcatagcgc tttctgtaag agtttgcaag 1239301 gtcttggagc ttttttgatg gaaataaaac gattccgtat ttcatattat gtccctcctg 1239361 gaaataaagt atgatagagt gttaaagcat ttttttcagc gccggggtga tgagcggctg 1239421 ccagtatgtc catttgtggt ctccgtcaaa tggctcgaaa tcataatcgg aaagcttttt 1239481 ctccagcagc tgtttcagct cccggttcgg ttctgtaaag tccagaatgt tcccgtctgt 1239541 cgtgtggacg tcagtttctt ttgttccgat ttggtgataa atagagaggt gtttgatatc 1239601 gtctgactgt tttacggctt ctagtacgtg tttgtcaaca tagggagact gcatgatgat 1239661 gttgccaaac atattcggat aatcaagcgc tgtcataagt gacacggttg ctccgagcga 1239721 atcaccgatc agcgttcggc cgtaaccgat ctgataggtt ggatactcat catctgcaaa 1239781 aggaacgagc tcatgggcga tgaaccgttt ataagccgaa aattttgaac cctccggatg 1239841 ataagtgttt ctgcgctctt ttacatcctt atagggaaca ccgataataa tgctccggtc 1239901 tatttcgcgt ttcgacagca attcctcaac ctgtctgccg attctcccca gcctgaaata 1239961 atcgtggccg tcctgcgcga taatgacatg gtatttataa agcggggagt agttggacgg 1240021 cagataaaca agcaaggtca tttcctcgtt aagctctttt gaaaagaatt tcttttcttg 1240081 cactgtgccg tttttcggtg ccataaaaac attcctccag gacatcacta tactttcttg 1240141 cattttcaat tattgtacca tgaattatta gaaatttctc tctttaaacg gttcggcaca 1240201 cgaagaaaaa agtgttgaaa taaactgtga attgcgctaa tataaaacaa tcagaaaatt 1240261 gaaatcgata tttcttatcg tgagaggtgg agggactggc ccttagaaac ctcagcaacc 1240321 ggcttgtttt gcatttgcaa agcgccaagg tgctaaatcc agcaagcgtt ttttatgctt 1240381 ggaagataag aagaagcgtt aaaccccttc ttcttatgaa gaaggggttt ttattttgaa 1240441 aagggaaggt gtcagctata tgtcacagca cgttgaaacg aaattagctc aaattgggaa 1240501 ccgtagcgat gaagtcacgg gaacagtgag tgctcctatc tatttatcaa cagcataccg 1240561 ccacagaggg atcggagaat ctaccggatt tgattatgtc cgcacaaaaa atccgacacg 1240621 ccagcttgtt gaggacgcga tcgctaactt agaaaacggc gcgagagggc ttgcctttag 1240681 ttcgggaatg gctgctatcc aaacgattat ggcgctgttt aaaagcggag atgaactgat 1240741 cgtttcatcg gacctatatg gcggcacgta ccgtttattt gaaaatgaat ggaaaaaata 1240801 cggattgact tttcattatg atgatttcag cgatgaggac tgtttacgct ctaagattac 1240861 gccgaataca aaagcggtgt ttgtggaaac gccgacaaac cccctcatgc aggaggcgga 1240921 cattgaacat attgcccgga ttacaaagga gcacggtctt ctgctgatcg tagataatac 1240981 attttataca ccggtcttgc agcggccgct tgagctggga gctgacattg tcattcacag 1241041 cgcaaccaag tatttaggcg ggcataacga tctgcttgct ggacttgtcg tggtgaagga 1241101 tgagcggctc ggagaggaaa tgtttcagca tcaaaatgca atcggcgccg tcctgccgcc 1241161 atttgattcg tggcttctga tgagaggaat gaagacgctg agcctcagaa tgcgccagca 1241221 tcaggcaaac gcgcaggagc ttgcggcgtt tttagaagag caggaagaaa tttcggatgt 1241281 gctgtatccc ggaaaaggcg gcatgctgtc cttccgtctg caaaaagaag aatgggtcaa 1241341 tccgttttta aaagcactga agaccatttg ttttgcagaa agcctcggcg gggtggaaag 1241401 ctttattaca taccctgcga cccagacgca catggatatt cctgaagaga tccgcatcgc 1241461 aaacggggtg tgcaatcggt tgctgcgctt ttctgtcggt attgaacatg cggaagattt 1241521 aaaagaggat ctaaaacagg cattatgtca ggtcaaagag ggagctgttt catttgagta 1241581 aacacaattg gacgctggaa acccagctcg tgcacaatcc atttaaaaca gacggcggaa 1241641 ccggggcagt cagtgtaccg attcagcacg cctcgacttt tcaccaatct tcatttgaag 1241701 agttcggggc atatgattac agccgctctg gcacgccgac aagaacagct ctcgaagaaa 1241761 caattgccgc actggaaggc ggaacaagag gatttgcttt cagttcaggc atggctgcca 1241821 tctcaacagc atttttactg ctgtcacagg gtgatcacgt tcttgtgaca gaagatgtat 1241881 acggcggaac cttccgtatg gtgacagagg tgctgacccg gtttggcatt gagcatacgt 1241941 ttgtcgacat gacggatcgt aatgaagtgg cgcggagcat caagccgaac acaaaggtca 1242001 tttatatgga gacgccatca aatccgacac ttgggattac ggatattaaa gcagttgttc 1242061 agcttgcaaa agaaaacggc tgcctgacct ttctggacaa tacattcatg acgccggcac 1242121 tgcagcgtcc gcttgatctc ggcgtggata ttgtacttca cagcgcgaca aaattcttaa 1242181 gcggacacag cgatgtgctc tcaggtttgg ctgctgtcaa agatgaagag cttgggaagc 1242241 agctgtataa gctacaaaac gcgttcggcg ccgtccttgg cgtgcaagat tgctggcttg 1242301 tcctgcgcgg attaaaaaca ttgcaggtcc gtttagagaa agcgagtcaa acagctcagc 1242361 ggcttgcgga atttttccag aagcacccgg cggtcaagcg cgtgtattat ccgggactgg 1242421 ctgatcatcc cggcgctgaa acccataaaa gccagtcaac gggagcgggc gccgtgctat 1242481 cttttgagct tgaaagcaaa gaggccgtta agaagttagt cgagaatgtg tcactcccag 1242541 tcttcgctgt cagccttggc gccgtggaat cgattttgtc ctatccggca acgatgtctc 1242601 atgcggcaat gcctaaggaa gagcgtgaaa aacgcggtat cactgatggc ctgctccgtc 1242661 tgagtgtcgg cgtcgaacat gcagacgatt tagaacacga tttcgaacaa gcgctgaaag 1242721 aaattgctcc agtttcggtt cgttaaaaaa gaagccgggg atagtccggc ttcttttatt 1242781 attgttcgtc atcaggattc agaatcgcga ggacttgatg atcctcccaa acgccattaa 1242841 tttttacatt ttttcgggcg atgccttctt tatgaaatcc cgctttttct aaaacacgca 1242901 tggacccgag attacggggc atcacaccgg cttcaatccg atgcagtttc aattcgtgga 1242961 acgcataatc aacaaccaat ctgactgcct ctgtcataat gccctttcca ttatgggctt 1243021 tgtctaaaaa atacccgatg aacgcagttt gcagcgcgcc acggatgatt tgaaagagcg 1243081 aaaccgtccc gattaatcta tcgtctgacg ctgtaaagat gccaaaatga tattcttcat 1243141 ctttctcaag tctttcctga tactcggtta ttcgttttct ttgcccctca accgtatagt 1243201 aatcgtctgc gcgtatcata gaaaactgtt cgaaaaaatc tcgattttcg ctttgcagcc 1243261 ccagattttc ttcggcatcc gttacttcta aaggtctaac ataaatggtt tttcctttta 1243321 acatatagtg atctctccgt tctcatgtca gcattcctct tacattattc tcagggaaat 1243381 gcaaatatcc tttttataag aaggaagaaa accaatttcc cataaaagtg ccaacatagt 1243441 tgccgattaa gtagccgagc gtaccgacaa gcatgatcgg ggcgacaagc tcccgccatc 1243501 ccttggcaat tgccatcgca gccgcagtcg tcggtccccc gacagtagcg ttgacggcga 1243561 gcagaatttc ttcaagccgc acacggaaca attttccggc agctaaggaa accgctaaat 1243621 tgctaatcgc aatgataaac acgaataata gaataagagg cgcattcgtg acgattaagc 1243681 ggagatctgc aggaatgccg atcaccacaa aaaacaaata aatcaaaaag gttccaagct 1243741 cctgagatcc attgagcctt tcaaaaaaac gcgggaaaag aaaaatgata agaacagtta 1243801 aagacgtaag aaccaggtac tgatcgccaa gcgtaccggt cagcagggga tgagaaaaaa 1243861 tgcttttaaa ataaccggaa accttcatac taaccgcaac aagcgcgaaa gcggcaccgg 1243921 cattaaaagc gatatccttt aaggaaatat ccttccgttt ccaatagctt tcagcactgt 1243981 ttccgctgtt tccatcggct tttaccttct cttcaaacgg catggcataa tgccgctgaa 1244041 accatttgag tgcaggaatg ctgattaaaa taaaaaacaa aagcgccatc ataaaattat 1244101 cagccacaac ggtagccgac acatattcac caggcgtctc aaattttgcc gccatcgccg 1244161 caaagttgac cccgccgccg atataagagg cgctgatcat cccaccgatt ttatctaagt 1244221 aaggaatatg ctgtttgagt agaaaaaaag ccaggatact gccaagcact gttccaacgg 1244281 agctaatcag aaaaataaac agcaaacgcc tgctttcctt aaaaatttgc ctaacattga 1244341 tctgaaacaa taaaagtggt atcgccagcg gtaccacata agaccacaca gtgtcataca 1244401 cgggcgactc aacaggaagc actcctacat ttgtaaacac catagcacct gcaagggcga 1244461 taatagcgcc cgacacagca gacgcccact taaagcgctg ctccagcccg atgctcactg 1244521 ccgcccacac cgcaataaac ccccataata cccatacatc atcagaagaa atcaaagaat 1244581 gcaaaacccc atcacctcta ttgttagaaa attaagacat attataatag ccggggaacg 1244641 gaacagcaag tccaaaaaaa gtttttctaa aaaagcagtt gacgaataga aggtaaggtt 1244701 atataataga acttgtcaga aagataacaa catacccagc aacacataca tatcatgatt 1244761 ccgtagctca gctgggagag cgctaccttg acagggtaga ggtcgctggt tcgagcccag 1244821 tcggaatcat agcttaaacc cttgcgcagc aagggttttt tactttgcgt taataaagcc 1244881 ggttcgtcaa attcgtgagt tgttggcgaa ctgttggcga aattcattga ccgcagtcca 1244941 aaaactacct ccaaacttac ttgattagtt caatagtaac aaacggaaga tcggatttct 1245001 gttaaatctt cattgagaat agccagtcca agaccgtcac ttcagccatg catcttttaa 1245061 atgaaatttt gtactgaaaa catcaattgt atttttaaat tctgctctag aatcagcccc 1245121 tttataataa tcttgataaa ttgcttgggg tgatactgat tcgtgatttg tgctatggtt 1245181 tgcaaggctt gtagcaaaag caggagcaac agtaacgagt aaagcaaggg ataatgcaaa 1245241 accagttaaa gctttttcaa tttcatttta agcacttctt tttttaaaat acaactttat 1245301 tattaaatgg aatacaaaaa catccaaggt gtttttttgt tagtaagttg agttaggggg 1245361 attggatggc acttagaata ttgtttctgc tgatgggatg ttgattctgg atatatttcc 1245421 aacacgatta caggccggac atgaaagcga accttgcttt gatcggggca atcatttcat 1245481 ttacggctgc ggtttacttt aaagatattg atgtattgag agaagaggga aaacaaatga 1245541 acggaatttc tgagcgttgg aacacgttta aattacaaaa atcccctgaa ccactctaga 1245601 tcaggggatt gctttcccaa cagcttatta agtagcggaa ggcatgatca acgatttagt 1245661 atcaatttat taattgcgaa tactagaaac ataccgtttt ccgccttcct tagaagtaac 1245721 atattctcga ggaacattaa gtctattggt agaatgataa cttacataaa gtttcatatt 1245781 tgctcggctc gttacgatag ccgtatgatc catccaacca tcagcatagc gaagacctat 1245841 tttattatgg taatcatagt gatatacatc tccaagcttt acatttgaat atgtatcaga 1245901 aacagtcttc atttttattc cgccagcttt taaaatgtat gatctaaagg ctcctgcatt 1245961 aacccaagca tctgtatagg gtttccattc tttaaagtac ggcattcttc cagctcttaa 1246021 tgcttgggaa acaaagttag tacaatcttt gtctttataa tatttatagt ttttatttgg 1246081 ttttaaggca tatttttctg catatttcat tgcagcgtaa ccactatatc ctttaacaga 1246141 tgttgcagtc acagttagtt gattagagtt agcagcattg aagttcatac ttactggttt 1246201 atcttcactt ttcacttctt ctttatcatc atttttcact tcttgcttat atttttttaa 1246261 aaattcatct aatttaacat ccgaagaata ttcttcatca ttttcatatt gtagagttga 1246321 agaagaatta tttaattgtg ttacatttag ttgcttagaa gaattactca atggtattac 1246381 atttagttga ttagaagaat ttttaacttg agagaaactt agattagaag tatttgttga 1246441 ttgagaactt tgtttattag aagttgtttt gggaatttca agtttaatat tatcgcccag 1246501 agatgttgtt actttttcaa caccaaaaac aaagtttcga gtaatataag cttcaacaat 1246561 tagcttattg tttttttcag aagtcttaac atcgtctata tcgtatgtaa actcgtggaa 1246621 tttttgtttg tccactttac ttaacgcaga atacagtaag actccttcgt cggaatcagt 1246681 caatttagac tctttaggat gcgctaaagg agtgttgtgt tcaaaatcat atttttgttg 1246741 ttctaacata tccttaactt tttcgtaacc aatctcgttg gtaattgaaa cattttcttt 1246801 agtctcttta ttagtagtgg ctgcaaaaac ttcatttgtt gacactaatg gtgacaatga 1246861 tagacataaa actagtgaag caagtaattc ttttttcata cgaaacctcc aataaaatct 1246921 aaatataagt aatatttatc atttacacca attgaaatat ggcataaaat acatgtaata 1246981 atataacata aaaataaata cataaaaagg tatcggagga aaaaatgaaa aagaaaacta 1247041 aaattatact ttctctcttg gcagcactta ttgttatatt gatagtactt ccagttctat 1247101 ctcctgttgt ctttacagct tcttcggaaa aaggagcaat cagacacgaa atttataaaa 1247161 gaggatatcc ctaccaaagc tactttgcag ttctccagaa aagagaagga gacaatgaat 1247221 ctgggaatct ttattatgta aattggctag attggaaaga tgaaacaggg caaactcctc 1247281 acttatgcta ttcgaaaaaa tcatcagatg gtgaatacga agtaagttgt ggcacagggc 1247341 cgtaaaaata aattttaaaa ttgaataagt ccaagacgga aagcctgcgg acactgatcg 1247401 ttttacagag aaatttgtgc ttcgatcggt gtccgttttt tttcgcaact aaccagatgt 1247461 ctatcgcgat tactagctat gaaaggagta attagacatg aaacagtcca aaaagaaacc 1247521 atcacagaag caacatgagc gcttagatcg tttctggcaa caaatgatga acactaacat 1247581 gcaaacactc agacgtggca aaggcggcgc ttataaacgc agaaagtaaa aagggagttt 1247641 gaggatgatg aaaaacggat tcgcttataa aaacggaaag cttgtgaata tcttttgcgg 1247701 caaagaagag ctctataacg agttgaaagc cttcttggtc aaaaccttca gtatcaacgt 1247761 gaaagaggta tcgaggccct caatatatcg cagaacaaaa agcaaacaac tggaatgaca 1247821 cttactctat ttaactatca ggagggaaag cactatgaca gatcaaatga ttgcatggga 1247881 gattgaggaa tggattcgtg attataaatt catgctgcgg gagatcaaaa ggctcaaccg 1247941 tgtattaaac aaagtggatt ttattagcac aaagctcact gcaacatacg gggaggaagc 1248001 gggcatgcca aggggatcag caggcgtcag tcaggcagaa ttgcggcaga tggaccgaag 1248061 agaaaggcgg cttcacaaat atgaatctat tgtgcattac ctggacaatg caatggaaca 1248121 cattgaagaa gaaaagcacc gaatcgttta cgattgcatg atggaaggca tgagctacac 1248181 tgctattgca aaccaccttg attgctcccg ggataccatc agaaagatca aaacagccat 1248241 aatcggcaac atcgtcaata aagtcaaaga agccaacttt ctgcaatatt tgaattcgtt 1248301 taaatcggcg gtgtaaaatg gggggcagga tcggcgcggc ggattattcc tgcgtcacca 1248361 ccaatttcat acaatgagta aaacctccca gtggtaagcg aggatcaact caactgggag 1248421 gtcttacata gtgaatcggt gataaaacag cagcagtatt gcgtacatgt taatatcccc 1248481 gacaaaatat gtttttttca acagattcgt tcgacaaatt ttgcaaattg ttaatcgata 1248541 acttttcatt cccgatatta aaaatgggag tgaattgtaa aatgaaaaaa cagaaaaata 1248601 ataaaaagaa gaatattgaa aagcgaaata ttgaaaagcg aaatattgaa gagaagaata 1248661 atgaggactt agaagaactg gaaaatgcga tttatactta tcacaaaaag gagctacttg 1248721 ctttctttct tgaaaaaact cgaattggtc atgataagga agaatacaaa aggttccaat 1248781 ctcttcttta taagttggat attgaatgtt tagaatttgc tatatcgaga ttttctcata 1248841 tagatattat ccatgatcat tcaaaatatg ttccagcctt tatcccttta tttgcagcat 1248901 atctcaccat gttctttaat ttttatgaaa aacattgggg agctttatct tttgctgctg 1248961 gtacaattgc tgctattgtt tggataattg cagtagaaag aaaacataga aatcaagcaa 1249021 tttctattat gaaaatattt gaacaagtca aagagagaaa agtgaaagac agatctaaag 1249081 actgaaagga gaaaatatga ataaggataa attaaggtat gcaatcttaa aagaaatttt 1249141 tgaaggtaat acccctttgt cagaaaacga tattggagtt actgaagatc aatttgatga 1249201 tgctgtgaac tttttaaaac gcgaagggta tatcattggg gtccattatt cagatgatag 1249261 acctcattta tacaaattag gacctgaact gacagagaaa ggtgaaaact acttgaaaga 1249321 gaatggaaca tggtctaagg cctataagac cattaaagag attaaagatt ggattaaata 1249381 ataagagcat cctgcggggt gctttttttg ttccctgtaa actgcttccg gtaagtctca 1249441 ggatagacaa ttggcggtta acggcttgag cacggtggtg gtttagaggg aatatctttt 1249501 ccaaaacaac acgaatcaga agggggcggc ggtgaatgta gatggccgaa aagcacattc 1249561 aggcgtataa ggattacgtc aaaggcatga aatacaagga ccttgccgag aaatacgggg 1249621 tgtcagtgaa caccattaaa tcgtggaagc agcggcatgg ttgggaaagg aaaaagggtg 1249681 cacccattga aaaaagtgtg cacacaaaaa aaggcgggca accgggcaac aaaaatgcat 1249741 tagggaacaa tggcggcgca ccacagaaga atcaaaatgc tgtgactcac ggctttttct 1249801 ctaaattctt gccagaagag acgcttgaaa tcatggaaga gattcaggag cgttcgccag 1249861 ctgatatgat atgggatcag atacagattc aatatgcggc cattcttcgg gcgcaaaaga 1249921 tcatgttcgt ttctgataag gaagaaatga tcaaagagct gaaaaagaaa aggtccctca 1249981 tatctgaggt cagcgaaatt gaagatgggc ttgtcattag ttttagtacg tggtttcgct 1250041 acagacttta cagtgaaaca aacacctaac acatttcaca ttgcttcaga ttgccttcaa 1250101 acttgataat ataacttcta aaccttccta taaaatgaag gttttttatt tgatttcaat 1250161 ttttaaatcc tttacataca gcgattgatt aactcgagca atcaatgtcg cagttatatt 1250221 tatttttcaa gaaaatgtta taatgaaaag ccataaaatg atgggagggg gaatttcgat 1250281 gcattacata acggcatgtt taaaaatcat cagtgataaa gaccttaatg agataatgaa 1250341 ggaattcaaa aaacttgagg aagaaacgaa caaagaagag ggttgtatta cattccatgc 1250401 ttatccgctt gagccatcag aacgtaaaat aatgctttgg gagatttggg aaaacgaaga 1250461 agctgtgaaa atccatttca caaaaaaaca cacaatagac gttcaaaaac aagaattaac 1250521 ggaagtagaa tggttaatga aaagcaatgt gaatgattga aaggctcttt aaaaagagac 1250581 attcaatgac ttagtatcag ccacttgtga ctaagtagta aattgttgtc caactcttat 1250641 tttttctatt taatattttt tgagacgaaa atgttttttt aagctgattt taaaatgtat 1250701 tcaaagtcag ctctgtttga tttaatggat tatattattt ggatagcttg ttaccatcat 1250761 aatggagata ctccttataa attggaggtt aaaataatga gtcattctca agaaaaaatt 1250821 gcactaatta caggagcaag cagtcaaggg gatattggta cggctatttg tcgtaagtta 1250881 gcctcacagg gtatacatat cttctttact cactggaatt ctgatacggc ctggatagaa 1250941 gaatttcaac aagaaatttt acgtatgggt gtccgctgtg aggcaatgaa aattgattta 1251001 tcagatgcac atgctgcatt cacaatacat gaaaaaattt cagataaatt aggatatcct 1251061 tccatcctta ttaataatgc agctcattcc gcaagtgata attatgtatc gttagatgct 1251121 aaatcacttg atgagcatta tgcggttaat atgagatcga attttcttct ttgtgttgaa 1251181 ttcgcccgtc ggtttaaaaa atctaattta atatcaggaa gaatcatcaa tatgacatca 1251241 gggcaggatt taggtccttt gcctggggag ttagcgtatg cagcaactaa aggagctatt 1251301 tctgcattta ctaggtcgtt atcacaagaa cttgcaccat tgggcatcac tgttaacgcc 1251361 gtaaacccag gtccaacaga ttctacatgg atgacagatg aaataagaaa ttttctttca 1251421 cctaaatttc caatggggcg tattggcaca ccagatgatg cagcacgaat gattgccttt 1251481 cttgcaagtg atgaggctga atggataact ggacaaatta ttcattcaga aggtggattt 1251541 attcggggct aagctaatga aacacggtat acaccaatgt atgatgtatt cccaaaacta 1251601 aatctaaact tgaagcgaaa ataaggtccc ttctcttttt agagggggac cttattttat 1251661 tcatgcatgt tttgcatcca gaaaatctgg cggataaaga ttaataaacc gttacatata 1251721 cttttccgaa tactgcagta cctttaaaca aagtaatcgt ggctttccct tttgatttag 1251781 ccgtcactaa accattttga tcgacttcag caactttttg gttatcagtc caataacgag 1251841 tagctgaatt atttttaaca gaataggttt ctccaacttt tagaggtaaa ttatagtctt 1251901 gaatcttgat aacatgtgta ggtgaaatag aaatgttctt tacttcagta ggtgtggagt 1251961 ttatttcatg agctgaagct accccgctga ccgacagagc taacgcagaa atcgataaag 1252021 cagaaacaac cgtttttttg aaattcattt tgaaacactc ctttaaagtt ttttgtcttg 1252081 cactataaca attcaataaa agtaattatt ttccttgtaa ataaatgtta ataatatgtg 1252141 aacgatcaat tgatttgagc taagaatatt gtgtgccctg cacagagttt gtatttatga 1252201 tggaaaattg ctgagagaga atggccatcc ttaaaatgtt aatagcacac atttgatggg 1252261 tattagtttg ttgagcgtgt ggaaattttg ttacctgcac tttatccccg aagataccaa 1252321 atcacttttc ttcatcatgt tcttactttc gtactcatac attagaaaat cttcgttcta 1252381 aataggtgaa gaattggagt atttttatga atttctgctg aatatacatt acatagcaaa 1252441 ctcaaagagt ataaaaatcg cttttttccg gaagcttcgg taaaaaacga aacttttgtc 1252501 tctatgattt tgttttataa tgtaaacggt ttcttatata gtatacttat actatcaatt 1252561 tgctcaagta gatactgaca ggaaggatag aaaaacagat ggaatacata aatacaagac 1252621 aaaaagagat tttgtatctg ttgttatctg aacctgatga ctatttagtt gtgcaagatt 1252681 tcgcagatag ggtacagtgt tctgaaaaaa caatccggaa tgatttgaaa gtgatcgagg 1252741 attatctcaa tgagcattct catgcacagc ttattcgaaa accagggttg ggcgtttatt 1252801 tacatataga agaacaggaa aggacctggc taagccaaca attacatact gaacattttt 1252861 cttctaggca gcggagcgat aaggaaagaa tgctgcacat tgcttatgac ttattaatga 1252921 atccgaagcc tgtttccgca aaagacattg ccgctcggca ttttgtcaat cgatcttcca 1252981 ttaaaaagga tttatacgca gtagaagagt ggctgaagcg ttttgatctc acactggttt 1253041 ctaggcagcg gcttggatta aaggttgaag ggaacgaaag aaataaaaga aaggcattgg 1253101 caagaatatc tgatttgatt cacaatacag cgtttaccag ccaatttatt aaaagtaagt 1253161 ttttacatta tgaagtagac tttgtgacga aagaaatcaa atcactacaa aaaaagcatt 1253221 ccctctattt cacagacgaa acgtttgaaa gtttgttgct gcatacattg ttaatggtcc 1253281 gccgcatcaa aatgaagcag ccgatttcat tgtccccaaa agaaatggcg gcagtaaaaa 1253341 agaagaaaga atatcaatgg acatttgctt gtttacagcg gcttgaaccg gtttttgcaa 1253401 ttcgcttccc tgaagaagaa gccgtgtact taacattaca tatattgggc ggtaaggttc 1253461 gttatccatt gcagacagaa gagaaccttg aaaatgctgt gcttcctaag gttgtagggc 1253521 atttaatcaa tcgtgtttca gagctgaaaa tgatggattt tcacaaggat caggatttga 1253581 tcaatggttt gaacattcat ctcaatactg tgctacaacg gctgagctac gatctttctg 1253641 tagcaaatcc tatgctcaat gacatcaaaa agatgtaccc ttatttgttc cacctcatca 1253701 ttgatgtttt ggaagacatc aatcaaactt ttgatcttca tattcctgag gaagaggcag 1253761 catatttgac attgcatttt caggcagcga tcgaacggat gcagggcagc agcgagacac 1253821 ataaaaaggc ggttatcgtc tgccacatgg ggattgggat gtcacaattg ctgcggacaa 1253881 aaattgaacg gaaatatcac caaatcgctg taatggcttg tattgcaaag gccgatttaa 1253941 aggattatat caaaaagcat gaggatattg atcttgtcat atccaccatt gcgctggaga 1254001 atataacggt tccccatatt gttgtgtctc cgcttttaga gcctggcgaa gagaagaaat 1254061 taagtgcgtt tatacgtcag ctgggcgaat cacaccgcca aaaacaaaaa acgtttcaga 1254121 tgctgaacaa tacgactcct tttttggttt ttttgcagca ggaggcggag catcgctaca 1254181 agttaatcga acagctggcg acagctttgt ttgagaaagg ctatgttgat aaggactatg 1254241 cggttcatgc ggtgatgagg gaaaaaatgt cggctacaaa tattgggtca ggcattgcca 1254301 ttcctcatgc aaacgctaaa tttattaaac aatcagcaat cgcgattgcc acattaaagg 1254361 agccgcttga atggggaaat gaaaaagttt cgctcgtttt tatgctggct gtcaaacacg 1254421 aggatcaaac tatgacaaag cagctgttta gcgagctttc atatcttagc gagcagccgg 1254481 ccttcgtcca gaagctgacg aaagaaacca atgtcatgac atttttatct catttggatt 1254541 attaaaagca gggattattc cttgcttttt ttgttatagg gaaaaatgcc tttattaccg 1254601 gaacctatgg taaaaaaagc gattttaatg agctgatttc ggtatacagt tgagacaaga 1254661 tcttattatt cacactttaa aggaggtttc ctatgaaact gttagcgatt acatcttgtc 1254721 cgaatggaat cgcccatacg tatatggcag cagaaaatct gcaaaaagct gctgacagac 1254781 tgggcgttag catcaaagtt gagacccagg gagggattgg tgttgaaaat aagctaaccg 1254841 aagaggaaat tcgcgaagcg gacgcaatca ttattgctgc agaccgttcg gtaaacaaag 1254901 accggtttat aggcaaaaaa ctgctgtctg tgggggtaca ggacggtatc cgcaaaccgg 1254961 aagaattgat tcaaaaagct cttaacgggg atataccggt ctatcgttcc gctacaaaat 1255021 cggaatccgg taatcatcag gagaagaaac aaaatccaat ttaccgtcat ttaatgaacg 1255081 gcgtttcatt tatggttcct ttcattgttg tcggcggatt attgatagcg gttgcattaa 1255141 cgcttggagg ggagaaaaca cctaaaggct tagttattcc ggatgattcc ttctggaaaa 1255201 cgattgaaca gatcggcagt gcttcatttt catttatgat tccgatttta gccggctata 1255261 tcgcctatag catcgctgat aaaccggggc ttgtgccagg tatgatcggc ggttatattg 1255321 cggcgactgg aagtttttat gacagcgcaa gcggcgccgg attcctcggg gggattattg 1255381 ccgggttttt ggccggatac gcggcacttt ggatcaaaaa attaaaagtt ccaaaagcca 1255441 tccagccgat tatgccgatt attattattc cggtgtttgc atcactgatt gtaggtttag 1255501 cgtttgtgtt tttgatcggc gcgcctgtag ctcaaatttt cgcctcttta acagtttggc 1255561 tggcggggat gaaagggtcg agctcgatcc ttctggcatt gattttaggg gcgatgatct 1255621 catttgatat gggcggtccc gtaaataagg tggcgtttct gtttggatcg gcaatgattg 1255681 gagaaggaaa ttatgaaatt atgggaccaa ttgctgtcgc catttgtatc cccccgattg 1255741 gccttggcat tgcgacgttt ttaggaaaaa gaaaattcga ggcatctcaa agagaaatgg 1255801 ggaaagcggc atttacgatg gggctcttcg gcattactga aggagcgatt ccatttgcgg 1255861 cgcaggaccc tctgcgcgtt attccaagta ttatggcagg ctcaatgaca ggttctgtga 1255921 tagccatgat tggcaatgtg ggagacagag tggcgcacgg cggacctatc gttgcagtgc 1255981 ttggcgcagt tgatcatgtc ttgatgtttt ttattgctgt gattgcagga tctcttgtca 1256041 ctgctctgtt cgtcaatgta ctaaaaaagg atattacggc gtctcctgtg ctcagtgaaa 1256101 ctgcaccgac ctccgcgcca agtgaagctg cggcagcaaa tgaaataaag cagccaattc 1256161 aaagccaaaa agctgagatg tcggaattta aaaaactgac agacattatc agcccggaat 1256221 taattgaacc aaatttatcg ggggaaacga gtgatgacat catagatgaa ttgattcaga 1256281 aattgtcacg aagaggtgcg ctgctttcag agagcgggtt taaacaagcc attttgaatc 1256341 gtgaacaaca gggaacaacg gcgattggca tgaatatcgc gattccgcac ggaaagtctg 1256401 aggcggtcag ggagccgagt gttgcctttg ggatcaaacg atcaggcgtt gattggaata 1256461 gcctggatgg atcagaagct aaattaatct ttatgattgc tgtaccgaaa gagagcgggg 1256521 gaaaccagca tctcaaaata ctgcagatgc tatctcgaaa gctaatggat gacaattata 1256581 gggagcggct gctctccgtg caaacaacag aagaagcata caagctgcta gaagaaatcg 1256641 aataaagcgg gggattttca tgacgactga accgttattt ttcaagcctg ttttcaaaga 1256701 aagaatttgg ggcgggaccg ctttagctga ttttggctat accattccgt cacaacgaac 1256761 aggggagtgc tgggcttttg ccgcgcatca aaatggtcaa agcgttgttc aaaacggaat 1256821 gtataagggg ttcacgctca gcgaattatg ggaacatcac agacatttat tcggacagct 1256881 tgaaggggac cgtttccctc tgcttacaaa aatattagat gctgaccagg acttatctgt 1256941 tcaggtgcat ccgaatgatg aatatgccaa catacatgaa aacggtgagc ttggaaaaac 1257001 agaatgctgg tacattattg attgccaaaa agatgccgag attatttatg gccacaatgc 1257061 aacaacaaag gaagaactaa ctaccatgat agagcgtgga gaatgggatg agctcttgcg 1257121 ccgtgtaaag gtaaagccgg gggatttttt ctatgtgcca agcggtactg ttcatgcgat 1257181 tggaaaagga attcttgctt tggagacgca gcagaactca gacacaacct acagattata 1257241 tgattatgac cgaaaagatg cagaaggcaa gctgcgcgag cttcatctga aaaagagcat 1257301 tgaagtgata gaggtcccgt ctattccaga acggcataca gttcaccatg aacaaattga 1257361 ggatttgctt acaacgacat tgattgaatg cgcttacttt tcggtgggga aatggaactt 1257421 atcaggatca gcaagcttaa agcagcaaaa accattcctt cttatcagtg tgattgaagg 1257481 ggagggccgt atgatctctg gtgagtatgt ctatcctttc aaaaaaggag atcatatgtt 1257541 gctgccttac ggtcttggag aatttaaact cgaaggatat gcagaatgta tcgtctccca 1257601 tctgtaacat ggcagggctt gagaaataaa tttgcgagtg aagacgccta ttctccagca 1257661 atgatctaaa taaaataaga gtttaatagt tggagaagaa atgttacact cttttctgta 1257721 tatggtaaag aatgaaaaaa cacgattcgg ttggtagtcc ggatgcatga ttgagaatgt 1257781 cagtaacctt cccctcctcg ggatgtccat cattctttaa tatcttttat gaggagggaa 1257841 tcgttatgaa attaacgatt tactacgatg gtcagttttg ggtaggcgtt gttgaagttg 1257901 tggacaatgg aaagctaaga gcctttcgtc atctttttgg caaagagccg agggattctg 1257961 aagtattaga gtttgttcat aaccaacttt tgaatatgat ggcccaagct gagcaggaag 1258021 gagtgcgttt acaaggcagg cgtcaaaaaa agatcaatcc aaaaagattg cagcgccagg 1258081 tttcaaaaga gttgaaaaac gccggagtaa cttctaaagc tcaagaggcg ataaagctag 1258141 agcttgaagc aagaaagcaa aagaaaaaac aaataatgaa agaacaacga gaacatgtaa 1258201 aagagcaaag gtatatgctc aaaaagcaaa aagcgaaaaa gaagcacaga ggtaaataat 1258261 ccaaacaaaa gcaggcgcag tgcctgcttt tgtaattaag gactctactt tgtaacatat 1258321 atccaatgtt tatactccgc tgatttatga ttcaatataa accctaactt ctccaaggtt 1258381 ttttgtgagc ctagattatc atgttcgcat cttgcggtga tccgggatac tgtttctcgg 1258441 cttaatgccc agtttattag tttttgggcg gcttccacac aataaccttt gcggcgatga 1258501 cttttatttg ttgcaaaacc gatttcaatc atgccatttt cgtctgggtc acctaaaaat 1258561 ccagttcccc caacaatttc ataattgtcc ttctttacaa taatccatga atcaaatcct 1258621 tttgttccat tgtttttgac taaaatctcg cggaaataag gtatcgcttc aaaaaaatca 1258681 gaatttggcc attcaccatt tgtttcatag cctaattctt tgatagcctg atgatcttgt 1258741 ttagacgcgg cgtcaagaag gggaatatca atcgtttgta atcgtaatcg attcgtttca 1258801 aggagaacca tatatttaat cctcttttct ttttactggg aataatgata acatataaca 1258861 attttctctg gtaccttggc agtagagaaa gatgaaaaaa ttgaggggga ttgaaagagt 1258921 gacaggtgag agtttgccca gaccaaaaac gggtaggaaa atgctgatgt taatgtgtcc 1258981 ctacccgttt ttctgttcct gaatgcaggg tttctgataa catgttgtgc taccttttcg 1259041 caatcaaata aagcgatatg gctctttggg tttgcacagg attatgaatg ataatgaccc 1259101 attggtttct tcgtcttgga aagcttgcta ccgcatacaa tggagcagta tcgcgcggag 1259161 tgaacccacc atttatcacg ttgatatctc ttccttcaag atgacaaact aagtattcac 1259221 ctggattgat gacctgttgg ttcgtccatg cgtaagaata aaagccgtct ccaagatctt 1259281 cggtggaaga tggggggaca aagccatcta cagtcaatgt gatttctctt cttcgctgtc 1259341 tttctgaaaa gtctggactt ctttgagggt tatgagtatg tgaaaagtaa ggaattaacg 1259401 cagggccata aaagtaatga tacaaagcaa ccactccttt attttccatt catacaaatt 1259461 gtatgtggga gttatttgtt cattcctgtt ttgttccatg tagactaata atgggctata 1259521 ggcgtccaag gaaatcaatt tgtccttccg ttgattcaat gctagtaacc ttgaaaatgc 1259581 aggttaggat gatagaattt acatattact gcaagaagtt agacatacat cattttgata 1259641 gtgggtgaaa acaatggcga aaaaaatggc aaaaacaaat gcggttcgtc tgatagaaca 1259701 gcagaacatc tcttatgagg tattagggta taaaacagac ggccagccgg tagatggcat 1259761 ctctgttgcg gaaaaaatcg gttattcttt gaaatatgta tataaaacgt tggttgcagc 1259821 agcaggaaca aatcattatt atgtctttgt tgtacccgtt gcagaagagt tagatgtaaa 1259881 aaaggcagca aaggtgacag gggaaaagaa aatagaaatg attgcaatga aggagctgtt 1259941 agcggtaact ggctatcttc gcggcggctg ctcgccaatt ggcatgaaaa aattgttccc 1260001 gacctatatt gatgcatctg cagaaacgct tgattttatt attgtcagtg cagggaaaat 1260061 cggtatgcag ctaaagttgg cgccacaaga tttagccaga tcatgtgatg ccgcatttgc 1260121 agaaattgta tagatgcaga tataggggaa cgaaaaagct tagtcatatc gattaagctt 1260181 tttccgcatc cctttcaaat atgatttcaa aataagcagc tgccccatac ccatctatac 1260241 tgggagcgaa aatctgaacg aatctccagc ctcttttcgc ataatcatgg atgatttgct 1260301 ggtagtcttc tttaggcctt cttctcatcg tactcagctc aactcttacg aattcatatt 1260361 ctttcatcgt ttgatccctc ctattaaggt atacgtaaaa tggagcgaga agttccgaaa 1260421 acctaggtta aggtcggaaa gtatatttca ctcactaaac aaatccattt atgcctgatg 1260481 cctgcatgca tctgggaaga gttaaggggc tataaaaacg aattttaccg ggtcagcagt 1260541 ccaaatgaat ctcttgctta ttgcatttga ctgagtatat aagtaaaaaa agagcggcca 1260601 gaacatataa gaaggagatg atcattaacg cactcataac agggtagtgt ttagcggagt 1260661 agatgaaaaa atcaagctgt gaaatttgtt tggggctgct gacggcatca attccattaa 1260721 gcagttttga gagtttagca gtatagttcc aatcaaatcg atctgaaaca agctcgcttc 1260781 cttgatacca attaacagca gctaaaaaca gaaataccat aatagaaaat ccaagctgaa 1260841 caactaaaaa tattcccttc acttttgtat gacctccaaa tctatgaata tgggaaaatc 1260901 aaacaatata ttaccaccgt atgggttatt cttgcaattt cacttccata caactcaaac 1260961 gcaagtctat ttttttgttt gtttttggct tataatacct gatgatggaa aaagagtgcg 1261021 ggtttataga ttagagaaac aaatgtattt cttagcattt tttatttgtg gagagagtat 1261081 agaagcattc gattagatct gctttttcac agaaacggtt ttcatctgtt tgcctgagct 1261141 ttacaattgg ctggcaaaaa aacaatgatt tctttcaatc aaaacatgca acgatgcgac 1261201 acattttata tcttgatgac ttatttcatt gcctttaagt catcctatcg agaaagcgat 1261261 ggtattttat gaacaaagaa accctaaaaa acatactcat gattttttca atatgcgcaa 1261321 cactccgaga aaccgatggt atgcgcatag ctgatagctg gattttgagt gagattatac 1261381 gatttttgat ttgcatggtt gtgttttttg ccatgacatt tctattagat gctgtttttc 1261441 caaacaaaaa agagtcacat taatgtgtgg ctctttttgc atcatctgat cagaaacatc 1261501 ataaatgaat cgatcatcat gatgaagaac agcaagcaaa aataaataag cgagtagaca 1261561 aacatatcct ttgcccactt cacgtcatcg tctgttttga atcctttgat gctttttttg 1261621 atccatatgc ctccgagaac caaggcggct aagaaataaa atgggcttat atggccggtg 1261681 ccgagagaga aaggaaataa tagcgtgacc ggcaccagga cggcaatata ttgcatcatt 1261741 tttatttttg ttacatgatt gcctttgact actggcaaga gcggaacgcc agcagcgcga 1261801 tattcctctt tgcgtcttat cccaatcgcc caaaaatgcg gcggctgcca cagaaacata 1261861 atcgtgtaca acagcactgc tgtcatactg aagtcaccgg ttacggcaca ataccccatc 1261921 aatggcggcg cagctcctgg gaagctcccg acaaatgtgc tccacacaga cgttcgtttc 1261981 acccataccg tatagatgat cgcataaaaa ataaaggcgg ccagtccgag aaaggccgtt 1262041 aatggattga gggaataaag catggcaaga cctgcgattc ctaaaacaga gccatatgtt 1262101 aagatcatgg ctggcggcat tttccctgtg accgaggccc tgctgcgagt tcgtgccatt 1262161 tttgcgtcca tatgccgatc aaaatagttg ttatagacag tgccggaagc catcacaaac 1262221 gcggttccca acattgctgt taccattgtc atcaaaaaag ccaagccggt taacgttttt 1262281 tctgcgcttg caaacgcgat ccaaaacccg ccgaaggctg ctatcgagtt tgatatgata 1262341 atgcccggct ttgcaagttt gataaaatcg taaatggtta cccggttcga agcttttatg 1262401 tattttgttt cagatatggc tgcagaatct cttgtattct ccaaaaatag acgcctcccc 1262461 caaaactgca tgcttttgtt atcgtaacaa gagggggaca gaatcacaat tatttcccat 1262521 atttgtcatg atattgtcat ttttaaaaca aaaaaatggg gagctggact gcccccattt 1262581 tgatatgtgg cgactagtaa ccgtaacctc ccccatatcc tccgccataa cctccgccgt 1262641 aaccgtacca agggtagtaa ggcggtcgcg ggcgcgggta gtaataaggc gggcgcggat 1262701 aaaacgggta gaacggataa tacggtcttg gataataata aggcggataa aatggcggtc 1262761 tcggacgcgg ataataataa ggctgtcttt catcataagg ggtaatttgt tcaaatgact 1262821 gttcattcaa agggtaatcc aagaggaaaa cctccctagc tttttttatt ccttttacca 1262881 tattcctgat gcttaagttg ggtgtatgta cattcatgaa attcggtttt ttttatgatg 1262941 aaattcctta aaaaggattg acatgaactt ctaaatctca tagtattaca aatgtgaaat 1263001 aaatgttact acaatgttac aaaaacattt ctaaatagat acagttccaa ctgatgaaga 1263061 gtaaatcgaa atggctacga aagaaggagt ttttgttgtt ggcaaaaaga atcaaatggt 1263121 ttcatgtatt aatagcagtt gtatgtgtgg tgggccttat cggctttttc cataatcatt 1263181 cattgaaaaa agaaacggtc atgaataaag taagaactga ttctcaatat gggaatgttg 1263241 agatcgcaac gcttgtgaat gacgggaaaa cttttaatta cgcggtaaac tatcctgttt 1263301 tcaaaaatga aaaaatggat tcggcattaa aaagattcgc agaaaaagag gttcgtcaat 1263361 ttcaaaagga aacaaaggac gttgaccaag agcatacgac aaaacgcaac gaattaaatg 1263421 ttgattataa aattgtccat tatgccaaac agacagtggc gattgtattt aatgaatata 1263481 aatacatcgg cggggcacac gggcaaaccg tgaaaaaaac gtttaactat gattttagta 1263541 aacaagcgtt tctttccatt gatgatattt tcaaagagga cgctgactac ttacataagc 1263601 tttcgttaat cgcttatcac gagctgaaaa agaataagga cattgccgcg gacgatgcac 1263661 tgttaaagga agggacggct ccgaaaaaag aaaatttcag ccgctttgcc atcaaggagg 1263721 attatatcga actttacttt gacacatatc aggttgcagc aggctatctt ggagagcaat 1263781 cgattgccat taagaaaagt cttttgaaag acattctgaa agaacaatat attgataaag 1263841 caaaaaataa aaataaaatc aaagaacaaa agccgaagca tgaagtgatt tctttaccca 1263901 aagaggaaac agttgatcca aatcaaaaag tcattgcgct tactttcgac gacggcccga 1263961 atcctgcgac aacaaatcag attctagact ccttgaagaa atataagggt catgccacgt 1264021 tttttgtttt ggggagcaga gttcaatatt atccggaaac gctaataaga atgctgaaag 1264081 aaggaaatga ggttgggaac cattcatgga gccatccgct tctcacaagg ctttcagtga 1264141 aagaagcgtt aaagcagatc aatgatacgc aagacatcat tgaaaaaata agcggatatc 1264201 gtccgacgct tgtaagaccc ccatacggcg gcattaatga tgaactgcgg agtcaaatga 1264261 aaatggatgt tgcgttatgg gatgttgacc cggaagattg gaaagaccgt aacaaaaaaa 1264321 caattgttga ccgtgtcatg aatcaggcgg gagatggaag aaccattttg attcacgata 1264381 tttaccgcac ctctgctgat gcggccgatg aaattataaa aaagctcacc gatcaaggct 1264441 atcaattggt gacagtttct cagcttgaag aggttaaaaa acaaagagaa gcgaaataaa 1264501 ttagaaaagg ctgtccgtac ggacagcctt ttttctattt aataagagcc tgtggtggcc 1264561 caaacattta agtttggtcc tgaatacttg ccgaaagcgt aagaagtcct tggatctaaa 1264621 tcatatacca tcggtgtata gcaagacttt tggccggcca ccgcttttcc attgccgcct 1264681 gcagaatcac aattatatct ttttccgtct gtgttccggg taatctccgc atttgcttca 1264741 tagccagacg tcaatgtatt attcatcgtg atttttgccc aagccgtttt acatgtactg 1264801 ctgaatttaa gctcgactac tccgatgact tgattgctgg cattcactaa gtttgaggat 1264861 ttttttgtag agccgctgga cgcacaatca ttgtaataag ggctttttcc atcgtaggca 1264921 tgggtttccg ccttggcggg tgcacctttg acggcaaaaa caaatactac tgcgaataac 1264981 accaatgaag ccttcataaa cagtcttttc aatttatgac ctccttaata tggcaaacaa 1265041 taaatcatat ggaggaacaa tcaaaacatg catgcttttt tgtgaacaat aaaggcggcc 1265101 gggaggatgg agttcttggc cgcctctggt atgaggttat gcttttacat caatggtttg 1265161 tccgagagtt ggatgttgaa tcatctttaa ggtttgatcg gcattttgct gggcggtgtc 1265221 cagccttttt ttcgttaaag caatatttac attctgggca agggatgctt gatgcatcgc 1265281 aaccgataaa gcaggaatat ccatggttcc acctcctatg ccttacctat cggcgggttt 1265341 gtatgatttt acagtgaaaa atggcttaat ttctcttgtt gacccttacg ctgcggcata 1265401 tcgtatgttt ttgacaagga gggaatcagg atgaatctag taatggaaaa gacctttgag 1265461 caatacgaaa agctgttttc aatggaagaa cagaaaagag aagatgtatt tcggtatacg 1265521 atgatgaggc cgtttgaaaa gatgtggacc gccatccaag ttccgctgaa agcgaaggag 1265581 ccaaacggct atgatgtgat catggctgcg aaaatgctgg gctatttgga tgtccgtgat 1265641 gctgaaagcg gccagaaagc actacaaata ctgaaagaat cacatgtttc agagacagct 1265701 gaatctgcac ttcggcaatg catatttttt gctgagcgcg aacagctgcg ggtgaatgca 1265761 aaggagatca aattcggcct ttatatcgct gatccaaata agcttcagct gcaaaaaggc 1265821 tactgcgggt ttggcgggat accgggcttt attcatgtat ggattaatcc gaacagttat 1265881 aacctgccaa ggattccttc cattattgct catgagtttc atcataatgt gcggttttcg 1265941 tatatagatt ttcatcatgg ctctgtaagt gtcggggatt atcttgtgat tgaaggattg 1266001 gcggaatcat tcgccagaga gctgtttggt acggaacgat tgggcccttg ggtaactcgt 1266061 tttgatcatg aagacttgca atattccatt gatgtgatta atgaggtgct ggatgtgaaa 1266121 ggattttcgg aagtcagccg ttatatgttt ggtgatccaa ttgctaacga ccaaggcttt 1266181 aagcctgcag gtttatcggc ttttgcgggt tatgcagttg gctatcatgc cgttcagtca 1266241 tttatgaatc aacatcatat cacgataagc gaggccacac gtttggatgc gaagaccatt 1266301 atttctcaat gcggtctgtt ttctacatga aaaaagcgtc acatacagcg gcgctttttg 1266361 attcccaaaa ccagcagttc tatggcggca caggcggcaa ttccgattgt atatgcttcg 1266421 atatcgctcc ataaaaaacc gtaccctagt acaagcccgc caagagaagt atctctaatc 1266481 tggtcgatcc attcggcatg atagagctgg ctgaattcaa tgacaaaaca gaaagaaaga 1266541 ctgataatgc ccgttatcat tgtcttcagc ttccgaaata gaaatccgca tcccgtgaag 1266601 atcatggcgg cccacaacga gtctcccaga taagtattga gggtatcagg aagaacactg 1266661 gagaatgctc tggatccaag ccccagccca atgatcagta tggtgaaaac tgcatatatc 1266721 caacgatttc gcttcattgc gaattgatac cccgtctctg cttcatctcc ctgtattgta 1266781 aggaatatag cttttatttg tccactaaaa aagcggctga atagccgcgt agggtgttta 1266841 ttttgctttt aggtttacat ggtcggctgt ctgatccgtg cctattacaa aatggagttc 1266901 atagcggcct gtatcatata cataatcgat ttcatcggta aacgggacgg ttaacacccg 1266961 atttactggt cctaattgct tctgcagcac ttccggcgta actccgccta aattcagctg 1267021 ccgttccaca ccggttccaa agtagcggat ttctgaaatt gtcatgtctt tatgatagga 1267081 aaatccgtag cccggctgtc ccatattcca gtgatataaa tcaaatcgat tgtctccccc 1267141 gactggtctt tccggttccc caaacgcagc gtggacatcc ccttttgtgc ttttgttaat 1267201 ggtaaggcct tgcgcctgct gaggcatttc ccctttatag gcggtgttat agaggttttt 1267261 gacaagctca gcggctgatt gattcgtgtt ttctgagagt gtgtttgttt gagctgcggc 1267321 ctttgccggt gctgaaaagg acgcagcccc aaagccggta aaacagcttg ttactgctgc 1267381 tgccgcggtt atagcagaca ttgtcttttt catgttaatc cctcctaatt gatctaccat 1267441 tccgtttccc cgtgtttttg caacgaaaca tgtgagtgcg ctttgtatgt tttattgagt 1267501 tgttgtaagg gaactgaaat aggtaattcg gtatataaag caagaaaggg gaatggagat 1267561 ggctggcaag aaaacaatca caataaacgg cgttgaaatg gaagcgtccg aggaacagac 1267621 ggtgctgcag cttttgaata acagctcgat tgaagtgccg caagtttgct atcatccaag 1267681 cttagggccg attgagacat gtgatacgtg catcgtcagc atcaatggtg agctgaagag 1267741 gtcgtgctcc gctgaattaa aggatgggga tgtcattgat acgctctcac ctgacgtgaa 1267801 aaaagcgcag gtcatcggga tggacaagat tttatataat catgagcttt attgtacagt 1267861 ttgcgattac aacaatgggg gatgcgaaat acataatacg gtgaaggaaa tgaaaatcaa 1267921 tcaccaaagc attccgtttg atcacaagcc ataccataag gatgaatccc atccgtttta 1267981 tcggtatgat ccagatcaat gtatattgtg cggacgctgt gttgaggcat gccaagacgt 1268041 tcaggtaact gaaacgctga ccattgactg ggagcggaaa cgcccgcgcg tcatttggga 1268101 taacgacgtg ccgatcaatg agtcgtcatg tgtgtcatgc ggccattgtt caacggtctg 1268161 tccgtgcaac gcgatgatgg aaaaaggaat ggaaggggaa gccggatatt taacaggcat 1268221 caataacgaa acgctgcgac cgatgatcga gatcacgaaa ggcgtagaga caggctacgg 1268281 ctcgattctc gcgatttctg atatggaatc ggccatgcgt gatgaacgaa tcaaaaaaac 1268341 gaaaaccgtc tgcacgtatt gcggcgtcgg ctgcagcttt gatgtctgga caaagggcag 1268401 agacattctg aaagtagagc cgcaggagga agcgcctgcc aacggcattt ctacttgtgt 1268461 gaaaggcaag ttcggctggg atttcgttaa cagcgaagaa cgcctgacaa agccgctgat 1268521 ccgtgaaggc gatcatttcc gtgaagcaga gtgggaggag gcgttattgc tgatcgccag 1268581 caagttcact gaattaaaag aggcgtttgg cccggattct ctcgctttta ttacatcttc 1268641 taaatgtaca aatgaagaat cctatcttat gcaaaagctg gccagagggg tcattggcac 1268701 aaataatgtg gacaactgct ctcgctattg ccaatctcct gcgactgccg gcctgttccg 1268761 gacagtcggc tatggcggtg attcaggatc aattacagat atcgcgcaag cggaccttgt 1268821 tttgattatc ggttcgaaca cgtctgagtc gcatccagtc ttatccactc ggattaaacg 1268881 ggctcataag ctgagagggc agaaagtgat cgtcgcggat atcagaaagc acgaaatggc 1268941 agagcgctca gatttatttg tccagccgcg tgccggatcg gatatcgtct ggctgaatgc 1269001 gatcgccaaa tatttaatag aaaacggcaa ggccgatgaa cgatttttga gagaaagagt 1269061 gaacggacgg gatgaatatg taaaaagcct cgcgccgtac acacttgaat atgctgagga 1269121 gaaaaccggg attgatcaag aaacccttat ccaaatggca gagatgatcg ggcaagctga 1269181 cagtgtgtgc gcattgtggg cgatgggcgt gacacagcat attggaggaa gcgacacgag 1269241 cacggcgatc tctaatctgc tgcttgtgac aggaaactac ggaaaaccgg gagcaggttc 1269301 ttacccattg cgcggccata acaacgtgca gggagcaagt gactttggga gtatgcctga 1269361 cagactaccg ggctatgaaa aagtgacgga cgaacaagtc cgccaaaaat acgagcgtgt 1269421 gtggggtgtg ccgctgccga aggagccggg tatgaccaac cacgaaatga ttgaaaaaat 1269481 ccattccgga cagttgaaag cgatgtatgt aaaaggtgaa gaaatgggcc ttgtcgactc 1269541 caatatcaat catgtacacg ctgcatatga aaagcttgat ttctttgtgg tgcaggacat 1269601 tttcctttca cgtacagcgg agtttgctga tgtggttctt cctgcgagcc cgagccttga 1269661 aaaagaagga acgtttacaa acacagaacg ccggattcag cgtttgtatc aggtatttga 1269721 accgctgggt gaatcaaagc cggattggca gattattatg gaggttgcca ataagcttgg 1269781 cgccggctgg ctctatgagc atcctgcaga cattatggag gaagcagcca agctgtcgcc 1269841 gatttatgcc ggtgtcacct atgaacgtct tgagggctat aattccctgc aatggcctgt 1269901 aaacgctgat ggaaaggatt cgcctttact ctttacagag cgcttccctt tcccagacgg 1269961 caaggccatt ctctaccctg tccagtggac agagcctaag gaattcggtg aggaatatga 1270021 tatccatgtc aacaatgggc ggctcttgga gcacttccac gaagggaacc tgacttacaa 1270081 atcaaaaggg atttcggaga aaacaccgga agtgttctta gaaatttctc ctgagcttgc 1270141 ggcagaacga gggattcagg acggaaccct cgtcagactc acatcgcctt tcggaaatgt 1270201 caaagtgaag tgcctgatta ctgatcgagt caaagggaag gaagtatatc tgccaatgaa 1270261 cgattcaggg gaagcggcga tcaacctgtt aacaggcagc catgccgata aggataccga 1270321 tacgcctgct tacaaagaaa catcggccaa gatggaaatt ttgaagcacg acggaatcag 1270381 cccgctgcct aagatcaacc accgcaacgg caatccgcag ccgcaaatcg gtgtgcaggt 1270441 tcataagaaa tgggcgcgga aggattatat tttccctggt gacgctgtga aaagggggat 1270501 gggccataat ggctaaagcg attaaacgaa tccaaaaaat cgaggtaaca gaagaggatc 1270561 agcgaaagcg tgatttgcgg gaaattgaag atgctctaat tgaccacaaa gaagcgattc 1270621 tcgaaacatt gcatatgctg ggccatatga acgagcgcgg ggtcctgccg ttgctccgcg 1270681 gcctttttgg tcaaggggat aaagttcttg atatcctggt gaaaaaggca gatacagagg 1270741 aaacagccaa tacgctgaaa aatctgcttc ttctgtttgg aacactcggc atgctggacg 1270801 tgaagcagct ggagcctctc attttgaaag tgaatgcggg tgtggcaagc gctgtagagc 1270861 agaaaaacag tgaagaaaag acaggttatt ttgatattat ccgctcgcta aaagacccgg 1270921 aaatcaacaa atcaattaca ctgctctttt cctttttaaa aggaatggga caagatacaa 1270981 aggagctgga acgcacgacg cagcctccgg aacaccaaaa acatcatcag gaaccccgag 1271041 agaaaagagg aatgaataag cgagattgac ctcccacccg agcggcttca gccagctcgg 1271101 gttttttgat gaaaaggtct aatggactag taaaaaatat tcaaatacta ggaagaagta 1271161 agattgtgat gaatgagata gaaataatcg ttactttctt acctgttaag aaaagggaaa 1271221 atctgattat aatagaaatc gattacttta gatgggggaa caatcatgaa aaaagtctta 1271281 ttactattat ttgtcttgac gatcgggtta gcgctttctg cgtgcagcca atcgagcgat 1271341 gcgtcagaga aggaaaaacc gaaagagaaa aaatcgcaag aagagcttga aaaggaactt 1271401 gataaggaat tgaaaaaagg cggtgagccg aagaccaaaa aagatgatca aatacataaa 1271461 ataggagaaa catttaaagc aggacatacg aattttacag tgaataaagt tgatagagtg 1271521 caaaaaggtg aatatatgaa tgttggcgga gctgtaaatg aggagacaaa aacaataaaa 1271581 gatgatgagg aacggcttat tatagaagtt acgatggaaa atatagggga agattcaata 1271641 agctacaatt ttatcgggtt tgatttaaga gataagaatg atcaatcagt gcggcctgtt 1271701 ttttctatag aagagaaggg cagaatcctt atgggaggaa cactagtatc ggggaaaaag 1271761 gttacaggtg tactcagtta tgtcatccct aaaggagaac agaaacatta cacactggta 1271821 tataatccgt ttttagctga tacaaatagc agtaatacag aagagagagt aaaggacgat 1271881 attgattact tggtgaagtt agattagatg ctaatttaca gttgcacgtt tttcatctgt 1271941 ggaaaacgtg cattttttat agcgaaactt gacttgaaag gatgagtgat aaaagtgcaa 1272001 accaaatggc tggaacgggc acagcggatt cgggcgatcg cccaagcggg gcttgctttt 1272061 tccaaggatg tgtacgacag ggagaggtac gaagagctaa tgaagcttag cgcggaaatg 1272121 atggcggatt actcggagaa ggacattgaa gttatcactg atttatggca aggcgagaag 1272181 ggctatccaa caccgaaagc ggatgttcgc ggcgctgtat tcagagagaa tcagattttg 1272241 cttgtccggg agaagcatga tgagctgtgg tcgctgccgg gcggattttg cgagattggt 1272301 ttatcgccgg ctgaaaacgt tgtcaaggaa atcaaagaag agtcggggta cgatacagag 1272361 ccgtctcgat tgctggccgt gctagacagc cataaacact ctcatccccc tcagccttat 1272421 cactattata aaatcttcat cgcatgcagc atgacggacg ggcaggggga aacagggatc 1272481 gagacgaatc atgccgcttt ttttccggaa gacagactcc cgccgctttc tcctaaacga 1272541 aacacaccct cacagcttag catgctgttt gactttttgc gccatccgga caagaaaacg 1272601 atatttgact aaaaaagaaa gagcctgtgg gctctttctt ttttataatg taatgtgttt 1272661 ttcgttggcg agtttcagaa gggtcaaaat agaatcggct tgtttatggc cgagtttttg 1272721 ctttaatttg ttttcttcaa ctaatcggct gccataaatt ttgacggagg ctttgtcgac 1272781 gacagtatgc cagttttcct gtttttttcc ctcaacaagc ggtttttcat gtctctcaga 1272841 aaaagagaac acaaagagta cgaatgcaag tgaaagtagg attccgacaa cttgtttttt 1272901 gtaatcagtc tgtgctgcca cgttgttctc tccttcacct tttaccttct atttaatcat 1272961 agaaccaaat tattttacat aatgggaaag tcatttttgg agttagtgca tttggttgaa 1273021 aacagagacg ttttttgagc ggagcggtgc aattgaatcc atattggatt tgcgtgctta 1273081 tgcctaaggt cacgttgtga gccaaaacag cagtgcagaa tagaaaaaaa ttgaaagatt 1273141 atggtaagat gaacgaaatt cgagggggaa tatatgatgc ctgcatcgaa catcgtgatc 1273201 gcctgcctgc tgttatcaat ttaattattt gtggtagtcc ctctcttttt cgaaagcggg 1273261 aggtgaagtg gaacattaat tgctgaattc tttcaagggg agtgaccgta catgaatgtg 1273321 ttaaaccgcc ggcaagcctt gcagcgagcg ctgctcaatg ggaaaaacaa acaggatgcg 1273381 tatcatccgt ttccatggta tgaatcgatg agaaaggatg cgcctgtttc ctttgatgaa 1273441 gaaaaccaag tgtggagcgt ttttctttat gatgatgtca aaaaagttgt tggggataaa 1273501 gagttgtttt ccagttgcat gccgcagcag acaagctcta ttggaaattc catcattaac 1273561 atggacccgc cgaagcatac aaaaatccgt tcagtcgtga acaaagcctt tactccgcgc 1273621 gtgatgaagc aatgggaacc gagaattcaa gaaatcacag atgaactgat tcaaaaattt 1273681 caggggcgca gtgagtttga ccttgttcac gatttttcat acccgcttcc ggttattgtg 1273741 atatctgagc tgctgggagt gccttcagcg catatggaac agtttaaagc atggtctgat 1273801 cttctggtca gtacaccgaa ggataaaagt gaagaagctg aaaaagcctt tttggaagaa 1273861 cgagataagt gtgaggaaga actggccgcg ttttttgccg gcatcataga agaaaagcga 1273921 aacaaaccgg aacaggatat tatttctatt ttagtggaag cggaagaaac aggcgagaag 1273981 ctgtccggtg aagagctgat tccgttttgc acgctgctgc tggtggccgg aaatgaaacc 1274041 actacaaacc tgatttcaaa tgcgatgtac agcatattag aaacgccagg cgtttacgag 1274101 gaactgcgca gccatcctga actgatgcct caggcagtgg aggaagcctt gcgtttcaga 1274161 gcgccggccc cggttttgag gcgcattgcc aagcgggata cggagatcgg ggggcacctg 1274221 attaaagaag gtgatatggt tttggcgttt gtggcatcgg caaatcgtga tgaagcaaag 1274281 tttgacagac cgcacatgtt tgatatccgc cgccatccca atccgcatat tgcgtttggc 1274341 cacggcatcc atttttgcct tggggccccg cttgcccgtc ttgaagcaaa tatcgcgtta 1274401 acgtctttga tttctgcttt tcctcatatg gagtgcgtca gtatcactcc gattgaaaac 1274461 agtgtgatat acggattaaa gagcttccgt gtgaaaatgt aatagataag gagactggag 1274521 attcatgaaa aagtaccata tttcgatgat caatatcccg gcgtacggac atgtcaatcc 1274581 tacgcttgct ttagtagaga agctttgtga gaaagggcac cgtgtcacgt acgcgacgac 1274641 tgaggagttt gcgcccgctg ttcagcaagc cggtggagaa gcattgatct atcatacatc 1274701 cttgaatatt gatcctaagc aaatcaggga gatgatggaa aagaatgacg cgcccctcag 1274761 ccttttgaaa gaatcactca gcattctgcc gcagcttgag gagttatata aggatgatca 1274821 gcctgatctg atcatctatg actttgttgc gctggctggt aaattgtttg ctgaaaagct 1274881 taatgttccg gtcattaagc tctgttcgtc atatgcccaa aatgaatcct ttcagttagg 1274941 aaatgaagac atgctgaaaa aaataagaga agcagaggct gaatttaaag cctacttgga 1275001 gcaagagaag ttgccggctg tttcatttga acagttagct gtgccggaag cattaaatat 1275061 tgtctttatg ccgaagtctt ttcagattca gcatgagacg ttcgatgacc gtttctgttt 1275121 tgtcggcccc tctctcggag aacggaagga aaaagaaagc ctgttgattg acaaggatga 1275181 tcgcccgctt atgctgattt ctttgggtac ggcgtttaac gcatggccgg aattttacaa 1275241 gatgtgcatc aaggcatttc gggattcttc atggcaagtg atcatgtcgg ttgggaaaac 1275301 gattgatcca gaaagcttgg aggatattcc tgctaacttt accattcgcc aaagtgtgcc 1275361 gcagcttgag gtgttagaga aagctgattt gttcatctct catggcggga tgaacagtac 1275421 gatggaagcg atgaacgcag gtgtgccgct tgtcgtcatt ccgcaaatgt atgagcagga 1275481 gctcactgca aatcgggttg atgaattagg ccttggcgtt tatttgccga aagaggaagt 1275541 gactgtttcc agcctgcagg aagcggttca ggctgtatcc agtgatcaag agctgctcag 1275601 ccgcgtcaag aatatgcaaa aggatgtaaa agaagctggc ggagcggagc gtgcggcagc 1275661 tgagattgaa gcgtttatga aaaaatccgc tgtcccgcag taaaaacata aaaaccgaaa 1275721 tcaatttgat ttcggttttc tgtttaaata ttttttttca tcccgcatct ccggcattct 1275781 ctaagaaatt ttccgccttt tacagagctt ttgaacagtg tgtaatcaca gttgtcgcag 1275841 cgcccgctgc gggcatccgg atattcattg aattcgtaaa caatcgatgt atcgtagcct 1275901 tttgtttcat attcttcttt tttggtttcc atgtcgatcc tccgttacaa gacgtgtctg 1275961 ctgtttatct tacagcaagc ttccggcgta ttcaatggat tttaggaggt tgggtttatc 1276021 ttgatttctc ccttggtttg cgccaaaata gctttattaa gcttatatac ataaaaagcc 1276081 tatgcaaaga ggagaggaaa cgggtatggg aaaagggtta cttggaaaac gcgtggcaat 1276141 cggtggctca cgaaaaacgg aagaaattag tacaatcatt gaaaaacagg gcggaatacc 1276201 tgtcatccgg cctctccaag gtacagttta cttagcagag aagcaggtgg agccggattt 1276261 gcggacgttt gcggaagaaa aagctgactg ggtcattttc acgacaggca tcgggttgga 1276321 gactcttgtc gatatggcag agaaaattgg actgaaagat gagtttctgc aggccattcg 1276381 ccaagcgaaa gcggcatgcc ggggatacaa aacgctgtct gcgctgaaaa agcttggaat 1276441 cacaccggaa gcttcggatg aagacgggac aacaagaggc ttaatccgtt ccttggagcc 1276501 tcacgacttt tcaggaaaaa cagtcatggt gcagcttcat ggcgaaaaag cgccggctct 1276561 catggcattt cttgaagaaa aaggcgcgtc tgtcctgccg attctgcctt atcagcacat 1276621 cccgccggag gaggaaacgg tggagcggtt atgccgagag ctgatgaacg atgaggtcga 1276681 tgccgtttgt tttacaacgg ccattcaggt tcgttccctg tttgattttg ccaaggggcg 1276741 aggttatatc aatgaagtga agaaggtatt cgaagaacgc gccatcgcag ctgctgtcgg 1276801 aaaagtgact gctgaagcac tgcgggaaga gggcattacg agactgcttg cgccagagat 1276861 tgagcggatg ggtgcgatga ttgttgagct ggccaagtat tatgaagaaa aggaataaca 1276921 agtacaaaaa gccgcttttc cctcggaaag cggcttttgt ctgtcattca ttttgcttca 1276981 gctgctgatg aacggtgaat aatgatgggt atgtcagcac gcttaagatt acacaagtca 1277041 gcgcggctga ggccatcgtt gtaaacacga ttaagagttg aaagcgtact gcctgaatcg 1277101 ggtccgcgcc ggctagaatc tggccagtca tcatgccggg aagctggaca agacccagtg 1277161 ttttctggct ttcgagcgtc gggatcatac tcattttcat cgctgaggta agaatgcgct 1277221 gtatggattg cttcggtgtg ccgccaagtg acaatattaa ttgaatttct tctttgcgaa 1277281 cgccgacttc tgagttaagc cggtttagaa acaaacttga gagcaccatc gaatttccga 1277341 tgaccatccc gctgatcgga atgacatatc gtgccgtaag cggaatgata tgaagagaca 1277401 gcagaattcc ctgcgtcaca atttctacga ttgctaacgc ggcaaacacc ctccaaaacg 1277461 aaccgatagt atttttcttt cgcttgatga cattttgcgc cgccaccgcg agcattaaca 1277521 gcaccatcag caggataaaa acagggtggt ctccgcgaaa aatcagcgac aaaacataac 1277581 cgatgataag cagctgcacc gcggcccgga tggtggcgat gatcatgtct ttttctacac 1277641 cggctttaaa ggattttgat aaaaacaagg cgatcaaaac aaagatcatc gttaaagaga 1277701 gagaaaggta atccattacc gagtgcctcc cttcaaaaat tctttcgctg cttcatgctg 1277761 cggagcggag aaaaatgtgt cggtttcagc gatttcaagc agccggccat ctgccataaa 1277821 ccaaatggta tcggctattc gttttgcctg ctccatatta tgagtgaccc acatgactgt 1277881 ccattttttc tcttgatgct gacgtttgat cagttcttca atctcaagag cagagaccgg 1277941 gtccaaggcc gatgtgattt cgtccaacaa tagaatggag gaaggatttg agagcgttct 1278001 ggccagtgac agtctttgcc gctgcccgcc cgataagtct ctggcgcttc tgtctaacaa 1278061 ctctggcggc agccctgcaa gcgaagccag cttttcagga gagtacagct gggattgatg 1278121 cagcctttgt acaagactta aattgtcacg cactgtcccg tcgagcacgg gagccgattg 1278181 aaacgcgagg gctgccgttc gcctcagctc attgacattc cattctctga cttcctttcc 1278241 gtatatgttg acttcgccgc tgtcaggcgt tctcattaaa ttacacatag aaaggagggt 1278301 gcttttgcct gagccggaag ggcctaaaac ggctacgatt gcaccctgtt gaatgtctcc 1278361 ggtgacatcc tgcagcacat cataggtttg tccatcttgt ttatagcttt ttctgactga 1278421 tctgaaggag atggctggta tgttttgtgt ttgatcgttt gcttccatta caataatcac 1278481 ctttcaatat aagtaggctg acattatatt taactataac gtgaaacaga ttccttttgg 1278541 tagcacaaat aaaggagaac aggctttcac ccattctcct gcagatgcta cgcagtcaga 1278601 tttgactgtg ctttcttttt cggttttctc ggctgtgaag cgaaggtatg taacatcatc 1278661 cccgctatta taatgaacaa accggcaaat gataatagag atgggaaaac gcctgacagc 1278721 agaacaattt caccaagcag cgcgaaaatc acttcaccgg attgagtggc ttcaacagct 1278781 gcgagttttt gcggattgtc tcttaccata tcagtggccc agaaaaataa aaccgtcgca 1278841 atgatgcctg agctgacggc aacgataaag gattgaacgg tttgacttgc tgttggaagg 1278901 ccatctgacc accagccgta agctgctaat ataagccaga atggaaggct tgccaatgtc 1278961 attccaagca cgcgctgaaa tgtatcaagc cggcctccgt attcttcgag cattcttcgg 1279021 tttcctaacg gataggcaaa agccgcaatg acaaccggca gcacactgaa aagcagcatc 1279081 ctcccagaaa gcgattctgc atgctgaagc tgaatcagag ccgctccaat caggatgatc 1279141 acagaagtgc caagtgaaac caggggaatc ttttggcgaa tgagctgcgg accgcccggc 1279201 atatcttgtt tgacataaaa caaaggagat aagagcaccc cggctacaat tgtaatttgc 1279261 caggttccag ctatgagcca ccccggaccg tatgcagccg caaatgtaat cggtgcgtaa 1279321 aaaagcacga aaccgacgaa gctccatttg atccaataaa acggcttttt cctcatttct 1279381 agtaagagag gcgtgaatgt ccctctcatg atgacaatca aacataaaaa tggcaccata 1279441 aaaataaagc gcagcgaaga gctccaaagc cagctgcctc ctgataactc catcgctctg 1279501 tttaatataa aggtaacggc gaaaaagagt gaagccaata ttccgataac gatagctttc 1279561 atgatatccc tcattctggc attatttttt tatactatac tattcggtat catgcagatc 1279621 aatggaatca tgagaaaaac atcatgtttg gcgaaccgct atatgtggaa gacaaaaaag 1279681 ggaggtgaaa ttgatggaaa gagagacaca gacatacttc tttccggatg acggcaggat 1279741 tccgaatcac cctgattttc cgctcgtggt gtatcaaaac gcgcttaagg acaccggact 1279801 ggcagagcgg atcgtcaccc ggcatggctg gtcaaacagc tggtcaggga gtgtttttcc 1279861 ataccatcat tatcacagca atacgcatga agtcctgatt gcccttagga gagaggctgt 1279921 gattcagttt gggggagaaa aaggggctgc catccctttc aaatcaggcg acgcagtcgt 1279981 gattccagcc ggagtcggac ataaaaagct cagctcaagc cccgatttta ctgtccttgg 1280041 cgcctatccc ggtggcgttc agtacgatat gaagacgggg aagccgaatg agcgggagga 1280101 agcggtcaaa cagattaagc aggcggcgtt gccggcgaat gatccgatca caggaaaaag 1280161 agagcctcta ttggaaatat gggtaaagtg aaggggagaa attgctggat tgtcaataac 1280221 tagtgccgca gaaacgatat gacatgagct ccatataaat taatttcata atcgaagcaa 1280281 ttcacgttca aattttgttc aaaaagtgtt atcatataga aggtaatcga attggagttt 1280341 tttgtgtttg ctattttcag agagagtaaa ggattttgac ttattcaatt gtttattttt 1280401 agataaaaat aatactgaat atggcaagat gaaaaactgg gtagtaaaca tttatttttg 1280461 taaatgattg tgcatgaatt cacaatcctt attcttatgc cttaaaagcg tgagacaggg 1280521 agaggcacta ccctttccaa aaaaatcagc aaactgctta tagtaaagga gaattggata 1280581 tgccagaaac aatcgatcaa acaaatgcgt ctgtcagcca aagccagcaa gatcttattg 1280641 atcagctatt aaagccagaa gttcaagaat cattgactgt tttagttgac cagcttccga 1280701 agctgactga gttagtgaat attttaacga agtcttatga tttcgctcag tctgtagcga 1280761 ctgacgaagt gttaaagagc gacacagtcg gtgcgatcac tgaaattctc gagcctgtaa 1280821 aagaaacagc gaaagaagta gctgcgactg cgatcgaagc aaaagaccgc gcggaagcaa 1280881 gcaacgaaac aattggactt ttcggccttc ttcgcatgct gaaagatcct caagctcaaa 1280941 agctgttccg ttttgctaac agctaccttg aagtcatgaa cgaacgcgaa aaccaaaaat 1281001 aatctcagat tcaaattgat ataaaggacg gaggatatac gatgtcaaaa catattgtca 1281061 ttctaggcgc tggttatggc ggagttcttt ctgctctaac agttcgcaaa cattacacaa 1281121 aagaacaagc acgcgtgaca gtggtaaaca aatacccaac tcaccaaatc attacggaat 1281181 tacaccgcct tgctgcaggc aacgtgtctg aaaaagcggt tgcaatgcca ttagaaaaac 1281241 ttttcaaagg caaagacatt gatcttaaaa ttgcggaagt aagctctttc tctgttgata 1281301 aaaaagaagt tgcgcttgct gacggttcta cattaactta cgatgcgctt gttgtaggtc 1281361 ttggttctgt aacggcttac ttcggcatcc caggtcttga agaaaacagc atggtattga 1281421 aatctgctgc cgatgcgaac aaagtcttcc aacatgttga agatcgtgtg cgcgagtact 1281481 ctaaaacgaa aaacgaagca gatgcaacaa tccttatcgg cggaggcggc ttaacaggtg 1281541 ttgagcttgt tggtgagctt gctgacatca tgccgaacct tgcgaaaaaa tacggcgtag 1281601 accataaaga aatcaaattg aaacttgttg aagcaggtcc gaagatcctt cctgttcttc 1281661 cggatgatct tatcgagcgt gcgactgcaa gccttgaaaa acgcggcgtt gagttcttaa 1281721 caggtcttcc tgttacaaat gtagaaggaa acgtaatcga tctgaaagac ggatctaaag 1281781 ttgttgccaa cacatttgtt tggactggcg gcgtacaagg taacccatta gtcggtgaat 1281841 caggcctaga agtgaaccgc ggacgcgcga ctgtaaatga cttcctgcaa tctacatctc 1281901 atgaagatgt attcgttgct ggagacagcg cagtttactt cggtccagac ggccgtccat 1281961 acccgccaac tgcacaaatc gcatggcaaa tgggtgagct gatcggttac aacctattcg 1282021 cttacctaga aggcaaaacg cttgaaacat tcaagccagt aaactctggt acacttgcaa 1282081 gccttggacg caaagacgcg gttgccatca ttggtgctaa ttctacaccg cttaaaggtc 1282141 ttcctgcttc cttgatgaaa gaagcaagta atgtacgata tttgacacat attaaaggac 1282201 ttttcagcct ggcttactaa tccttttaat gaatctggca ttgccaaaag cattcctttc 1282261 cgagtgcttt ctggcaatgt ctttttttat gtttatgaca gcgttaacat ttcattttca 1282321 aaaaagagat tgatcccaaa ggaatataaa ggtaaaataa aaacaaatca aaatgttaac 1282381 gttaacattt tgaaatagaa tgaaagacgg tgaggacatg gaacccttca tgggcaaaaa 1282441 ctttttattg aaaaatgaaa ccgctgtcag cctctatcac aattatgcga aagacatgcc 1282501 aattattgat taccactgcc acttaagtcc gaaagaaatc tatgaaaata agacatttca 1282561 aaacatcacg gaagcctggc tgtatggtga ccattataaa tggcgcatca tgagagccaa 1282621 tggaattgag gagacataca ttaccggaga tgcgcctgat gaggagaaat ttatggcttg 1282681 ggcgaaaacc gtgccgatgg cgattggcaa cccgctctac aactggactc acttagaatt 1282741 gcagcgtttt tttggcattt acgagatttt aaacgagaag tccgggtcgg ctatatggaa 1282801 acagacaaat aaactgctca aaggggaagg cttcggggca agggatttaa tcgtgaaatc 1282861 aaatgtaaag gtcgtgtgca ccacagatga ccctgttgat tctcttgaat accatttatt 1282921 gttaaaagaa gacaaagact ttcctgtcag tgtgctgcct ggatttcggc cggataaagg 1282981 acttgagatc aatcgtgaag gctttcctga gtgggtgcag gcgcttgaag atgccgctgc 1283041 catatcgatt acaacctatg atgagttttt aaaggcgttg gaaaaacgag tgcgattctt 1283101 ccactcagcc ggcggcagag tttctgatca cgcgatagat acaatggtat ttgccgaaac 1283161 aacaaaagaa gaagctggac ggattttttc tgacagatta caaggaacag aggtttcttg 1283221 tgaagatgag aagaaattta agacatatac gcttcagttt ctttgcggtt tgtatgcgga 1283281 gctcgattgg gcgatgcagt ttcatatcaa cgctttaaga aacacgaata caaaaatgat 1283341 gaaaaggctc ggacctgata cagggtatga ttcaatgaac gatgaagaaa ttgctaagcc 1283401 tttatacaag ctgctgaact cagttgagat gaagaaccag ctgccgaaaa cgattttata 1283461 ttcactgaat ccaaatgata actatgtcat cgccagcatg atcaacagtt ttcaggacgg 1283521 tattaccccg ggaaaaatac aattcggcac agcctggtgg tttaacgata ctaaagacgg 1283581 aatgctcgac caaatgaaag cgttatcaaa tgttggcctt ttcagccgtt ttatcggcat 1283641 gctcaccgat tccagaagct ttctttcgta tacgcgccac gaatatttca ggcggatcgt 1283701 ctgcaatttg attggagaat gggtggaaaa cggcgaagtg ccgcgcgata tggagcttct 1283761 gggaagcatc gttcagggga tttgctatga caatgcgaaa cactactttc aatttcaaga 1283821 agagaaagca aacgtgtaac aaagtgtccg ctcagtatcg ctgagcggat cactatccga 1283881 aaattcttaa gacacagagg tggaacatgc gaactgaact ggcaaataag gttgtgtcgg 1283941 tcgaaacgga aaaaaggctt tcattgaaag agaaaatgtc ctatggcttt ggtgattttg 1284001 gcaacggttt tatgtttgat ctcggccaga tttatttatt gaagtatttc actgatgtag 1284061 cgggaatccc cgctgcgatg gccggcggca tttttttagt cagtaagctg tttgcagcga 1284121 taacagatcc aattgtcggc tcatcaatcg attatcgcaa aaacatcggc aaacggggga 1284181 aattcaggcc ttatctatta atcggcagca tcgtgcttgc ggtgcttact gttcttattt 1284241 ttctgtctcc caatgtatca acgaccggaa aactgatata tgcatatgca tcctatatga 1284301 tttggggcat cggctattcg tttgtgaata ttccgtacgg ctcattaggg gcagcgatga 1284361 ctcaaaattc tgaggaccgg acctccattt cgacgttccg ccaaatcgga tcacttggcg 1284421 ccttgtttat cacaagtgtg gccgtgatgc cgctgctcgt caagtttgat aatccgaagg 1284481 tcggctaccc ggtggtcatg ggcttgttcg ccgcgctcgg tgtgttttgg ttttatattt 1284541 gctaccgcaa ctgcaaagag cgcattatca tatcggaagc acccaaagaa aaattaacac 1284601 tctcatctgt cgtcaaaaca tttattacaa ataaaccgct gttaaccctt gtcctgatga 1284661 cgattttttc aatttccgca tacaacatta aatccgccat gctcgtctat ttcgcacaat 1284721 ataacttggg caatgttgaa ttaatggctt atatgaactt catcattatt ggttcttcct 1284781 ttttgggcgt cgtattcctt ccaaagctcg tcaagatgtt tggaaagaaa cgaacggcaa 1284841 tgatcggctt tggcatcagt gtggccgcgg atctgatcaa ctttatgctt ccatctaacg 1284901 tttatgtgtt tacaattctc gccagtatcg cctttatcgg aatcagtatc ccaaatggca 1284961 tcacgtgggc tcttgtctcc gatattatcg actatggcga atggaaatcc ggtgaacgga 1285021 aggaagcaac gacatattca cttttcaatt tctcaagaaa gcttgctcaa tctttgtctg 1285081 gctttctctc ggggatcggt ttggggatta tcggctatgt gccgaatgca gtccagacag 1285141 cacaggcgct gattggcatc aaagcgctgc ttcttctgta tccggccatt gctttggcat 1285201 tagcgatgtt cattatcggc tttctttata aactcacaga ccagcagcat gctcagatcg 1285261 ttcaggatct tcatcaaaag agctgacaat ataatataaa gaatatttaa aataatttgt 1285321 aaataaaatg tgtttgtagg ggtttcgctt ggagagtgcc caaaaaactg aaaaggaagg 1285381 aggcacttgc ttgaaaacga taacaattgc agctgaagaa gcaaaggaac tcgtttggca 1285441 aaagctggac ggtgccggtt tgaatgaacg agatgctgaa aaagtggcag atgttctcgt 1285501 gcacgctgat ttgcgcaatg tacattcgca tggcgtgctg cacacagaac actatgtgaa 1285561 caggctttta gcgggaggga tcaatcctgg ggcacagcct gtttttaaag agacggggcc 1285621 tgtgaccggg gtgcttgacg gagacgatgg tttcggtcat gtgaattgcg acatggcgat 1285681 ggaccatgca attgacatgg cgaagaaaaa aggagtcggc atggtcacgg ccgtaaacag 1285741 cagccattgc ggagcgctaa gctattttgt gcaaaaagcg gctgacgaaa agctgatcgg 1285801 aatggcaatg acgcatacag acagtatcgt tgtcccattt ggggggagga ctcctatttt 1285861 agggacaaat ccgattgctt acggagttcc ggctaagcat aaaaaaccgt ttatcctaga 1285921 tatggcgaca tccaaagtgg cttttgggaa gattctgcag gcccgtgaag agggcaaaga 1285981 aattcctgaa ggatggggag tcgatgaaaa cggagaagca gtaactgatc ctgacaaggt 1286041 cgtctcactt tcaacattcg ggggcccgaa aggctatgga ctatcgattg tagtggatgt 1286101 gttttccgga ttgctggcgg gcgcggcttt tggccctcat attgccaaaa tgtacaacgg 1286161 ccttgatcaa aaaagaaagc tggggcatta cgtttgcgcg atcaatccat ccttttttac 1286221 tgactgggat acgtttttag agcagatgga tgccatgatt gatgaactgc agcaatcacc 1286281 gccggctgtt ggattcgaaa gagtgtatgt gcccggcgag atcgagcagc tgcatgaaga 1286341 aagaaataag aaaaacggaa tttctatcgc ccggagcgtg tatgaattct taaaaagcag 1286401 gtgagtaaaa tgaaagcggt tcaagtgcga aaagcgtatg atctggtgac agcggaggtg 1286461 aagaagccag ttctttcaaa ggatgatgaa gtgctcgtga aagtcaagcg agtcggcatt 1286521 tgcggttcag acatgcacat ttatcatgga acgaatccgc tcgctaccct cccgagagtc 1286581 atcggacacg aggtaacggg acaagtggag gcagttggtg cgaatgtaca gagcctaaaa 1286641 cccggtgatc atgtggtgat tgagccgatt tcttattgcg gatcgtgcta tgcctgccgc 1286701 aaagggcggc cgaatgtttg cgccaagctt tctgtatttg gcgtacatga ggacggaggc 1286761 atgcgggaat atattgtgct tccggaaaga cagcttcacg cggtctcaaa ggacttgcct 1286821 tgggaggaag cagtcatggc cgagccttat acgataggcg cccaggcagt gtggagaggc 1286881 caggtggaaa aaggtgatac cgtcctgatc cagggagcgg ggcccatcgg gatctgtgtg 1286941 ttaaaaatgg caaaactggc gggcgctgct gtcatgatga ctgacttgaa caacgagcgg 1287001 ctggcatttg cgaaagaaaa cggcgccgat gctgttgtaa atgtccaagc agaacatgtt 1287061 gccgagcggg tccttgaatg gactgggaat gaaggagcaa acgtggtcat tgatgctgtt 1287121 tgcctgccgg agacttttgc actttcaatt gaggctgtgt caccggcggg acatgtggtt 1287181 gtgcttggat ttgatgaaag agcggctcag atttctcagc tgccaattac aaaaaaagaa 1287241 gtcacgataa ccggatcccg attgcagacc aatcagtttc caaaagtggt agagcttttg 1287301 aatggaggcc ggttaatgca taacgggctg gtgacccata cattttcagt tgatgacgtt 1287361 catcatgcat ttcagtttat taaggagcat ccagatcagg tgcggaaagc cgtcatcacg 1287421 tttgattaaa tgactgaatc cggaggtgcg agcatgaata tgacattccg atggtatgga 1287481 cgaggcaacg atacagtcac acttgaatac gtgaagcaaa ttcccggtgt caaaggcatc 1287541 gtttgggctc tccatcaaaa gcccgtcggc gacgtgtggg aaaaagaaga aatcagagcc 1287601 gaaactgaat atattcaatc ctatggtttt catgctgaag ttgtagaaag cgtgaatgtt 1287661 cacgaagcga ttaaacttgg gaacgaagaa cgcggccggt atattgaaaa ctacaagcaa 1287721 acgatccgca accttgccgg atttggcgtg aaagtgatct gctataattt tatgccggtt 1287781 tttgattgga cacgcacgga catgttccgg ccgctagaag atggatcgac cgctctgttt 1287841 tttgaaaagg ccaaggtgga aagccttgat cctcaagagc tgattcggac ggtggaggaa 1287901 gcatccgaca tgacactgcc ggggtgggag cccgaaaaat tggctcggat caaagagctt 1287961 tttgctgcct acagaacggt cgatgaagaa aagctatggg acaatttatc attctttttg 1288021 caggaaattc ttcctgttgc tgaggcctat ggtgttcaaa tggccattca tccggatgac 1288081 ccgccgtggc cgattttcgg actgccgcgc attatcacag gagaggcaag ctataagaaa 1288141 ctgcgggcga tatcagattc accgtctaat tgtatcaccc tttgtacagg ttcaatggga 1288201 gccaatcccg ctaacgacat ggtggagatc gctaaaacgt atgccggcat cgctccattt 1288261 tcacatattc gcaatgtgaa aatttatgag aatggcgatt ttattgaaac atctcattta 1288321 acaaaggatg gttcgatcaa cattcaaggc gtgatggaag aactgcataa gcaggattac 1288381 gaaggatatg tcagaccgga tcatgggcgc catctttggg gcgagcaatg ccgcccggga 1288441 tatggcttat acgatcgggc acttggcatc atgtatttga acgggctgtg ggacgcttat 1288501 gaagcaatgg caaaaaaaga ggtgggcata tgatcccgct gcatgagaac ctggctggta 1288561 aaacggctgt catcactggc ggcagcggcg tgctttgctc tgcgatggcc cgggagctag 1288621 cccgtcatgg catgaaggtg gcgattttga atcggacggc tgaaaaaggc caagcggtcg 1288681 tgaaggagat aacggcggct ggcggcacag cgtgcgctgt tgctgcggat gtgctggaca 1288741 ggatgtcact ggagcgggca aaggaagaca tccttggcca atttggcgct gttgatctgt 1288801 taattaacgg ggctggcggc aatcatcctg acgcgataac cgatgtggag acatatgaag 1288861 aagcgggaga aggccaatcc ttttttgata tggatgagag gggctttcta actgtattct 1288921 ccaccaactt caccggtgcg tttctggcct cgcaagtgtt tggtaaagaa ctgctgaagg 1288981 cggattcacc cgcgatcatc aacctttctt ccatgagtgc ttattcacct atgacgaagg 1289041 ttccggcata cagtgctgcg aaagcatcca tcaataattt tacgatgtgg atggctgttc 1289101 attttgccga aaccgggctg cgggtcaatg cgattgcccc aggcttcttt ctgacaaaac 1289161 aaaatcatga tctgctgatc aaccaagacg gaacgttcac cagccgatct cacaaaatta 1289221 ttgcgggaac accgatgaag cgcttcggaa aaccggagga tttgctcggt acgctccttt 1289281 ggctggcgga tgaatcctat tccggttttg tcactgggat caccgttcct gtcgatggag 1289341 gatttatggc ttattcaggt gtgtaacgaa agcggtgcaa cagaaactga accaacatag 1289401 gggtgaggtt gagatgtttt caaaagataa gcttcccgtt atcctttttt tgttcctggc 1289461 aggggtgatt aattacctgg atcgctcggc gctttccatt gcagctcctt ttattcagga 1289521 tgatctcaca ttgtctgcca cacaaatggg cttgattttc agcagttttt cgataggtta 1289581 tgccattttt aattttcttg ggggcgtggc atccgaccgc tatggggcaa agctgacctt 1289641 gtttgtcgcg atggttgttt ggtcgctgtt tagcggagca gtcgccctcg cttttggctt 1289701 tgtcagcctg ctgattatac gcattctctt cggaatggga gaaggcccgc tttcggcgac 1289761 catcaacaag atggtgaaca actggttccc gccgacccag cgggcgtccg ttatcggtgt 1289821 aaccaacagc ggcacgcccc tcgggggagc catttccggc ccgatagtcg gcatgatcgc 1289881 agtggcgttc agctggaagg tatccttcgt tctcattatg attattggat tgatatgggc 1289941 agtgctctgg ttcaagtttg tcaaagaaaa gccgcaagag acgatcaagg aagcaccggc 1290001 aataaaagca gaaacgtctc ccggagaaaa aattccgctc accttttacc tgaagcaaaa 1290061 aacagtcctg ttcacggcgt tcgctttttt cgcttacaac tacatcctct tcttcttttt 1290121 gacatggttt ccgagctatc ttgtcgacga gcggggatta agtgttgaat cgatgagtgt 1290181 catcacggtc ataccgtgga ttttaggatt tatcgggctg gctgcggggg gatttgtttc 1290241 tgactatgtg tacaaaaaaa cggcccgaaa aggtgtgctg ttctcgcgca aggttgtgct 1290301 tgtcacgtgt ttgttttcat cagctgtcct gattggtttt gccgggcttg tggcaacgac 1290361 tgcgggggct gtcactcttg tcgctctgtc agtgttcttt ctttatttga ccggtgctat 1290421 ctattgggct gtcattcaag atgtggttga tcaaaacaat gtcggttctg ttggcggctt 1290481 catgcatttc ctcgccaaca cggcaggaat tatcggcccg gctttaaccg gatttattgt 1290541 tgaccaaaca ggcacgtttt ctggagcatt tttgcttgcc ggtgggctgg ctgtcttcgc 1290601 ttcacttgct gtgattcgtt ttgtccgtcc aatcattggt aagccagcgg gaacagaagc 1290661 tgagaatcct gtgtcttatt aatctggaaa tatagtggga gaggcggtat gtttgatgat 1290721 acaatataca gtaaataatc gcagccggta tgataaggaa gggaattaga tggtaaccat 1290781 aaaagatatc gcaaaactcg caaacgtatc ccacactact gtttccagag cactcaacaa 1290841 cagcccttac atcaaagaac atacgaagaa aaaaatatta gagctagcag agcagctcaa 1290901 ctatacacca aatgtaaatg cgaaaagtct ggcgatgcaa aagtcgcata cgatcgggct 1290961 attctttaca agcattacaa acggaacctc acacagcttc tttgcagaca ctatcaaagg 1291021 cgtcaatcaa gccataagtg aggattacaa tctgtatgtg cgcggcattg atgatctgaa 1291081 aaactatgac tccgttacac cgatgagata tgacggcatc attttaatga gccaaagtga 1291141 cattgataat tcttttattt accatattcg cgaaaaaaac attccgcttg tcgtgctgaa 1291201 tcgtgatatt gatgatcgta ccatcacgaa tattttgtcc aatgacaagg aaggctctca 1291261 agaagctgta gaatacttca ttcagtccgg acatcaagac atcgccatca tcgaggggat 1291321 cgaaggcttt aaatcctccc agcagcgaaa ggaagggtac ttatccgcac tgattcaaca 1291381 tcatattccg atcaagcatg aatacagtgt caaaggacag tacgatatgg aaagcggctt 1291441 tcaagcgatg gagcggctgc tggcactgcc gaatcctcca accgctgttt tttgttcgaa 1291501 tgatgacatg gcaatcggag cgatgaatgc gatattcgca aagggcctgc gcgttcctga 1291561 tgatatttcg gtgatcgggt ttgatgatat tgggttttca cagtacatca cgccaaggct 1291621 ttcaacagta aagcgcccag tggagaaaat aagcgtgctc ggtgcgcaaa aactcttgtc 1291681 gctgatcagc gagcccgaaa caaaagcaga aaaaatcttg gaaaacacag aatttatggt 1291741 gcgtgattca gtcagacgat tgacgacgtg atgtcccgtt tttcagcggg cattctttat 1291801 acagaaaaat gttaacgtgt gcataaagtg agagggaggc aataagggtg cagaagctga 1291861 ataaaaatgt gtacgatcac tatactcagt atccagaaaa aattctccaa ttcggagaag 1291921 gaaactttct tcggggattt atcgattggc agattgatca attgaatcaa cacactgatt 1291981 ttaatgggag cgtggcagtt gtccagccaa gaggctcaga aaaaatcaaa cgattaaatg 1292041 agcaagatgg attatataca ctttttttac aaggaatgaa agacggagaa gcggtaaacg 1292101 agcatatgat tatcaactca atcagccggg gaattgacct gttttctgat tatgaagcat 1292161 acaaagaatt ggcatcaagc gaaaggcttc ggtttattat ctccaacacc actgaggctg 1292221 ggattgtatg tgatgaaaaa gatcgtttag aggataggcc gcaaaaaaca ttccctggga 1292281 aattaactgc atttctttac tttcgctatc aggcttttaa aggagatcag acaaaagggt 1292341 gtgtcctgat cccatgtgaa ctgatcgaga ataacggtga aaagctgagg gaaacggttc 1292401 ttcattatgc acatctgtgg aagctggagg aaggatttac acagtggatt catgaggcca 1292461 atacattttg taatagttta gtagaccgga ttgttccggg ttttcccgtc gacagcattg 1292521 atgagatcac ggcagatctt ggctatcagg atgatttgat agttgtggga gagcaatatt 1292581 atttgtgggt tatcgagggg cctgattgga ttggaaaaga acttcccttt gcggctgcag 1292641 ggctgcatac aaagatcgtc agcgacctca ccccataccg gactaaaaaa gtaagaattt 1292701 taaatggcgc tcatacagca atgacgccag tggctttatt atacggcttg aagactgtta 1292761 gggatgcagt cgagcatccg gaagtggggc gatttataag agagctgatt gatgacgaaa 1292821 ttcttcctgt tttaaaaatg gaaggtcttt ctcagtatgc tgacgatgtg ctgaaccgtt 1292881 ttaaaaaccc gtatattaag cattacctgg aaagcattgc attgaacgcc atttccaaat 1292941 tcaaaacgag aaacctgccg actcttaagg aatatgctga acaaaaggga cagcttcctg 1293001 aacgcttggt gttttctttc agcgctcttc tgtattttta tcatgataac gagacattgc 1293061 aggatgatcc ggcagttctt caatttttca aagaggtttg gtgtcaggag gatggcgaca 1293121 tgcttcggat tgcatcaaga gtgttaggcg aacagcggct gtggggggca gatctcaatg 1293181 agataccgaa gctgactgat agagtcgctg tttacttgaa tcatattcat gagctgggca 1293241 tgcagagggc tcttgaacaa tactgcatac aagggggaga ggtacgttga agtcgtttat 1293301 aaagattcat aagcaagata atgtccttct tgctctgcgg gatattcaaa agggagagag 1293361 gctgcatgct tacggcgtgt cgattgaagt aaaggatgat ataaaaagag gccataagat 1293421 tgcattgcag tctatcaaag aaaacgacag catcgtcaag tacgggtttc caatcggtca 1293481 tgcatcacaa gatatctcga tcggagagca tattcatgtc cataatacga aaacaaacct 1293541 gtctgatatc caattataca gctatacacc gagatttgat gaaaatccgt attctaatga 1293601 gaaccggacg tttaaaggtt ttagaagaga aaacggagat gcgggtgtac ggaatgaatt 1293661 gtggattgtc ccaactgtcg gctgtgtcaa tggaatagca gaaaaaatgc tgcagcgttt 1293721 tgtcagagaa acaggggata tcgctccatt tgataacgta ctggtgttaa agcatcaata 1293781 cggatgctcg cagcttggcg acgatcatga aaatacgaag cagatcctgc tgaatgccat 1293841 tcgccatcca aatgccggcg gcgtcttggt gttagggctt ggctgtgaaa acaatgagct 1293901 ggcaagaatg aaggaagcac tgcaagatgt gaacttgaag cgggtgaagt ttctggaatc 1293961 ccagtcggtg accgacgaaa tggaggcagg cgttgctttg ctgaaggaaa ttcatgaagc 1294021 ggccaaagga gataagagag aagacattcc gctgtctgaa ctgaagatcg ggctgaaatg 1294081 cggaggttcg gacggttttt ccggcataac cgcaaacccg ctgcttggac gtttttcaga 1294141 ttatctcatt gcacagggag ggagtactgt gctgacggaa gtaccggaaa tgttcggcgc 1294201 agaaaccatc ctgatgcagc gggctgccaa tgaagaagtg tttcataaga tagtcgattt 1294261 aatcaatgat ttcaaacaat actttattaa acatgatcag ccggtgtacg aaaatccttc 1294321 accgggcaac aaagcgggcg gcatttctac acttgaggat aaatcgctgg gctgtacgca 1294381 aaaagcgggg atttctcctg tcacggatgt cttgaaatac ggtgaagtac tcaagacaaa 1294441 agggctgact cttttgagcg caccgggcaa tgatttgatc gcctcctccg cattggcggc 1294501 tgccggctgc caaattgtcc tctttacaac gggaagaggc acgccgtttg gcacctttgt 1294561 cccgacggtg aaagtagcga caaacaccga gctgtatgag gcgaagccgc attggattga 1294621 ttttaacgca ggccttttag cagaggatga tgttcatgag gaatatgtgc tgcgtgagtt 1294681 tatccactat atgattgagg tggcaagcgg ccagcttgtg aaccatgaaa aaaatgattt 1294741 caaagaactc gccattttta aatcgggtgt gacgttataa taagaaaagg ctatccttca 1294801 agcggatagc cttcttcatt aaatcaattt taaaccgctg actaaaataa tggaagccat 1294861 aataaattgc agtggacgcg gggagaatcg aggcgaaaga tggctcccga tcagtacgcc 1294921 gggaattgaa ccgaggagca gattagctgc cagcatgtaa tccacgcttc cgaagcttgc 1294981 gttcaaaatg cctgctgccg taacaagaag aaaagcatgc gcgatatcgg ttccgacaat 1295041 ctgtgacgct ttcatgttaa ataagtaaat catggcgatt gcaaataatg agccggaccc 1295101 gattgatgtt aatccgacga taaacccaaa cacaacacca ataagaattg tcagcgccct 1295161 cttattttca agcggcatca gctgccagcg gttggggcga agttttctat ccaaaaacaa 1295221 acgaacgatg attgaaatgg caaccagcgt taacacatat cctagagcgt gcttaataat 1295281 ttcttcctga tgctggtgaa aggcggggaa caaatgcaat atgccaatgg ctagcgaagc 1295341 actcggaata ctgccgatgg ctaagtattt taccaattta aagttaatcg ttttctgccg 1295401 ccaatgggag gcaacgccaa acagctttgt gatcgagtta tatacaagat ccgtaccgac 1295461 cgcgatggaa ggattaattc caagcacaat taaaagggga gttaataagg ccgctccacc 1295521 cactcccgtc aatccgacta aggctccgac aaacaaaccc atcaatatga tgcttacact 1295581 catgataaag gcctcctgaa aacccgacta gaattcaccc gaatcttatt cgcgttggtc 1295641 aagtattaat tgtaagtgct ccatcggctg ctgaaaaacc cgagctctat ccgctccctg 1295701 atggtatcat tcaattgaca acaccttata catcaggaga acacgtcttt caggtgcaac 1295761 gagcacttgc ggctctgtat ttttaccctg ataaaggcgc tgttaacaac ggaattgacg 1295821 gcgtttacgg accgaaaaca gctgacgcag ttgcccgttt tcagtctgtt aacggtctaa 1295881 ctgctgacgg tatctacggg cctgcgacga aagagaagat cgcagcgcaa ttaagctgat 1295941 caaagaccat aaaaatcccg gagccgctcc gggatttatt ttttcttctt caactttttt 1296001 ataattccag cactgcgctc cctcacccga agcgagtacc cggaaagccc aaaccttccg 1296061 taatcaacaa acttcacacg cctcaccaat tttttcactg tatcacctga cattatcctc 1296121 tgtttgtatt tattatatgt caccctttaa gaaaaggaat aaggacaaga gctgttttcc 1296181 cttgtccttt tagtgtgatc atgctttttt tcgtttatac tcgtcaatca gccgttcgtt 1296241 ttctttgaag attcttgctg tatgcggact gacttgatag cttgcgacac tggtggttga 1296301 acgttttttc aggattttaa acggcttcgc cgctctgggc tcgcatctgt tttgaaacgc 1296361 acgttccatt atccttcacc ttcctcctca attggcagca ccaaatcata tatgctcgtt 1296421 aatgacgtaa atagcaaata atcaaattcc gtgacaatgc tgtcagacgt cagcttgatg 1296481 acatagttct gtgtctcgat ggtaaaaggg atgagaacca cttttccgta ttggtcgtaa 1296541 taaacatcct ttcgatcgag ccgtgtttgt acatctgccg gatcatccat atgctcggtt 1296601 aaccggtctt tatcagcctg tgtcgaatag tggcaaagag aagccgttaa gttcatttta 1296661 tcagcatagg ttttcagcag cttatcaata ccttcagcat aagcatctat acttccataa 1296721 taaacatgga tcggttcgtt tttcaatagg tattggtatg ttttcagccg attgagatac 1296781 atgtggagca tttcgttgtt ttcttcaaga atttctcttg tgtctgtttc aagctcgctg 1296841 ccggccagtt ttttgacata tgcacttaag aagataaaag catcaatcaa agcaaaactg 1296901 actgcgacaa tgagataccg ttcccagtgg gtaaataggg aagtgggctc atatgtccag 1296961 tataccatag cgcccagaac aaacagcaaa taccaagttt tccgaatggc ggacattttt 1297021 tctttgacct tcgcttcgaa acgccacgtg gcatacacgt ataaccccag tccggccacg 1297081 atgcaccaga ccatgatctg aaagaataaa accatattcg aatccctcac atctgaaata 1297141 ggttctgctt attgtattcg agagatccgg atggttttcc tgttccatca aaaaaaccgc 1297201 tcctttgaca gaagcggtgt gacattaaaa tatcatattt aaaataaagt aggcgatggc 1297261 accaagtgtc gctgaaatcg gaagcgtgat gacccatgta atgagcattc gcttggccgt 1297321 accccagttt acgcctttta cgcggtggga cgcaccgacg ccaagaattg atgaagaaat 1297381 gacgtgggtt gtactgaccg gcaaatgaat aaacgtggcg ccgaaaataa tggctgctcc 1297441 ggttaagtca gcggaaacac cgtttaccgg acggattttc atgatctttc cgccaacggt 1297501 tttgatgatt ttccagccgc cgattgatgt tccgagaccc atggctgtcg cgcaggcgaa 1297561 ttgcacccag gtaggaatat cattagcaga agtatgtaaa ttcgctgtga tgagagccat 1297621 tgtgataatt cccattgctt tttgcgcatc gtttgttccg tgtgtatacg attgcagggc 1297681 agctgttaca atctgcactc tgcggaattg cttattcgtt ttcgccaagt tgctgtcttt 1297741 gaaaatcagc ttaacgatgc tataaagaat aaaaccaagg acaaaggcaa taattggtga 1297801 tagaatcagt gcttcaatga ttttaatgaa gcccttatag tttaacgctg caaatccggc 1297861 tgccgcaatg gctgcaccgg caatagcgcc gatgatggca tgggatgagc tgcttgggat 1297921 accgtagtac catgtgataa ggttccaggc aattgcagcg agtagcgcag ccaaaatgac 1297981 aacagagcca ttttccagcg tataaggatc tacgatgtct ttcgtaatgg ttttggcaac 1298041 acctgtaaac gtcattgctc cgacaaagtt catcacagca gccaatataa tggcatggcg 1298101 cggttttaac gcttttgttg ataccgaagt cgcaattgcg tttgccgtat catgaaaccc 1298161 gttgatgaaa tcaaacgcca gagcacaaat gactattagt atcgttaata ttaatagaat 1298221 atccattttt acccctcgtt acgcgttttt cataatgatg gtttcaagat tattggcaac 1298281 actttgacaa gagtcggcga tttcttcaag cgtttcgtat atttcacgat attgaatgac 1298341 tttgattgga tctgtttcat ttccgaaaag attctttaat gattttctgt gcaagttgtc 1298401 acaactgtgc tcatactctt taattttgat tgcgtgaggc tgaatatcct ttaagcgatt 1298461 ttctgccagc agctcgatcg taatcaaaat ctctttcgca cattctctga tatatccgct 1298521 gaatttatca atatgctcgt ctgatgaagt aattgagaaa atctccatca tggcagagaa 1298581 atgttcgatt ccgtcaagca catcatccaa gctgtttgtc agctgaagga tatcttcgcg 1298641 ctcaatagga gtgatgaacg ctttgttaag ctctttaatc atgacatgaa catgattgtc 1298701 accttttgtt tcatattcct ttaacgtatc tgcaaattct ttaagagtcg tttggttagt 1298761 gaccttaaaa ttcacaaaat attctgcagt ttcgtctatg ttctttgcaa tttctgttaa 1298821 aaggagtgag aacttatctt tttttcttct tatcattaaa aaccctccat agtttgaatg 1298881 aacaatgcac acatcaaatt attatatagc cttttgtcga aaaaaaacag gtaaagtcga 1298941 aaaaaacgta tcttgacttt tttgataaat cgtgtctcct tattttgacc tacttcgctt 1299001 taaaaaaacg acccaagttt gcaaaaactt tctgcttaac gtaaaaagta tatcaaaagt 1299061 tgtgtttttc ctgtcaactt ttatcttctg tttcaccaaa aaacggttcc ctaaacaagg 1299121 gaaccgtttt atcagcttgc ttttcgtttt ttcatcccgt aataaacagg cagtccggca 1299181 aggccgatga ggatggataa tccgcagctc attgtatctg taatgagtgt gctgcctaac 1299241 acaaagaagg agcccgcgat tgccagaatt ggcataaatg gataaagcgg aacactgtag 1299301 gcgcgctttt ctccctttgc tcgcttgcgg agaataaaca ctgcaaaaaa ggccatcaca 1299361 taaaaaatgt agatcatgaa aatggagatt tctgagagct tatcagggtt gctgatcagc 1299421 atcataatca aagccaaagc aatttgaaaa gaaatcgcaa tccatggtgt gcggaacgac 1299481 gggtgtacat gtgacagttt ttcagcaaat ggaagctgtt tgcgttccgc cattgcaaat 1299541 gaaacacgcg ggaaagaaag cacctttcca tttaagcacc caaagatgct gacgataatc 1299601 cctacactga tcagctttcc gccaattgaa ccgaacagca tggttgcagc ggtgcttgtc 1299661 gcattttcac caagcgtgac aatttcgttc gctgacagga tgtgaagcaa tgcaaaatta 1299721 atgaaaatat agatcgccgt tacaattaat aatccgcccg tcatagcgcg tggcagcagc 1299781 ttttcgggat ttttcatttc tccgccgaga gcggcaagga gaatccatcc gtcataagca 1299841 aacaacgtag ctaaaatagc cgccccgaag ttcatatcag aaatgctttc gtttactgct 1299901 gtgaagatgt gctgatcgcc tttccaaagg ccaaagacga tgatgcaggc aatcggaatc 1299961 agttttccga tcgttgtcag cgtttggaca aaaccgccgt attttgtacc gataatatta 1300021 atgacgcata aaaagagaac tgctataatt ccaatgactt ttgatagtcc agatccccag 1300081 ccgaaaagat tcgccattaa agatccaaaa tataaaccca gcgcgccaat aatcgccggg 1300141 ccgtaaatga taatctgcac ccagccgcac aaaaatcccc aaaactcgcc gtacacttct 1300201 tcaaggtacg tataaagccc gccggttttt ggaatctgcg ttccgatttc cgcgattgtc 1300261 aaaccgcccg ccagtgttaa aataccgcct aacagccagg cgaaaagcgc catttttgaa 1300321 tcacctgaat aagcaagcac agcgccgggc ttcataaaaa caccagaacc gataatggtt 1300381 ccgatgacaa gagtaagggc aaacaagagg cctatctctt ttttcaaacc gttgtcttca 1300441 gtatgcatgt ccttaacctc ctatgatgtt gaagcttcat gttgaagaat ctattttttc 1300501 atattgtaaa ccctatttta gaaaagtgaa ataaaataaa ttttctgatt ttcgaaattt 1300561 gctttgtgta cagcagataa aactgtagaa atacctgttt taatggtcta taaacgaata 1300621 aaattcataa tttttattta caaagttcgt gttttatgta ttaggatttt agccggtaca 1300681 gaggggagat gagaattcag aaaatgaacg aaccttcggt gaagctgata tgttgacttt 1300741 ctcatgcgaa taaaatactt tgttattaga acaataaata tacaattatg atatgatatc 1300801 tcgaaatcga gataaaataa cctggaggga cagcatatga aagttaacgg cattcaccac 1300861 gtatcggcat taacggccga cgcacaaaaa aacttggatt tctataagaa agtattagga 1300921 ttaaagctcg tcaaaaaatc cgtcaatcag gatgaaccga caatgtacca tctgttctac 1300981 ggagatgaag tggcaaaccc gggaactgag ctgacgtttt tcgagattcc ccgcattgca 1301041 ccgtttcatg cgggaacaaa cagtatttct tctattggat tgcgcgttcc aggcacagaa 1301101 gccctgcatt actggaaaga acgttttgaa gagcagcaag taacgcacag cggcatctcc 1301161 aaaagagccg gacgtgacat attggcattt caagatcatg aggggcagcg acttgtgctg 1301221 actgctgatg aggaaggaaa aggatatggc ctgcctgtta aacagagcgg cattccggaa 1301281 gaattttcgt ttcgcgggtt agggccggtt gaactgactg tgccatatgc tgaaccaact 1301341 ttacacgtat tgacgaatat tcttggattt acagaaatca gccgtgaacc agtcgaaggg 1301401 caaggaaccg ccgttattct ggaatcagga gaaggcggtg ctgcaacgga aatccattta 1301461 atagaaagaa acgatcttcc gcgagagcgt caaggcaaag ggagtgttca ccacgtcgca 1301521 tttcgggtaa gagatgaaga agaacttgcc gggtggcacc ggatcatcag ccgcgaaggc 1301581 tttagcaatt caggcatagt tgagcgctac tatttcaagg cgctgtattt cagagaaccg 1301641 aacggcattt tgttcgagtt atcaacagac ggaccgggct ttatggtaga tgaaaatctt 1301701 gatgagcttg gccaaacgat tgctcttccg ccatatctag agcatcgaag agcagaaatt 1301761 gaagcaaaat tgaaaccgat ccaataaatt gtgattcttt tgccttccgg cgccgccgga 1301821 gggctttttt tattaccata attaattttg acctaaacag catgccttat tagggaggaa 1301881 atatcagatg ctgattggga gaaatggctt aaaacccttt gcaaatatgg gtgattggta 1301941 tggaatggcc tcggcaaaaa tattgtcttt gtttattaat agtttattca tatttgcttg 1302001 ttacactatt tcaaagttag acaaaaagga gtgaaaaata agtggaaaag aaaaaacgcg 1302061 agctggatat cgtcctcctc ctcattttgc tcgcatctgc attcttaaat atctataaca 1302121 tttggaagga cgacacggtg aatccttatt acaccgcggc agttacaagt atgatgcaaa 1302181 gctttcataa tttcttttat gcttcgttcg atgctgccgg ctttataaca gtagataaac 1302241 cgcctgttac ataccaaatc caaacgatca gcgcactgat attcggtatg cacggctgga 1302301 gcgtcatcct gcctcaggca cttgctggtg taggttctgt ccttcttatg tacttgctga 1302361 taaagccgac atttggaaaa acggcggcgc gtattgcctc atttgttatg gcatgtacgc 1302421 cgatagctgt agctgtagca cgtacaaaca atgttgatgc attactggta tttttcttat 1302481 tgcttgctac atggcttctc tttaaagcga tcagaaaagg aaagctgatc tggctgttag 1302541 cagcattttt cgttgttgga gtaggtttta atacaaaaat gctgcaggct tacatgattt 1302601 taccggcttt cttattgttc tatctgattg cggcaaacgc cacaatcaag aaaaaaatcg 1302661 tttcattggt aagtgcgtta gccgtattag cagccgtttc gttatcgtgg ccgctcattg 1302721 ttgacaatat ccctgcaagc aagcggcctt atatcggaag cagccaaacc aactctgttt 1302781 tggaattggc tttcggctat aacggaatcc agcggctgac aggccaaaat tcaggcggcg 1302841 gccagggtgc gccaaacaaa gacgcttcaa aagaaatgtc ttcttctgat aacactcaag 1302901 caccgcctaa tcagtcatca agcaacagct catcaagcga tggtaaatcc tcaaatggca 1302961 atatggcggc gcctccatcc aatggccaaa tgccaagcgg cggtcaagga ggccctccaa 1303021 gcggcggaga tggcggccaa ggcggacccg gcggagacgg agggaaaggc ggtacaggaa 1303081 ccggttcgaa aatgcaatca ggttcaggga tgtttggaac gggaacacct ggtccactgc 1303141 ggcttttcca acaagagtta tctgatcaaa tcagctggct tctgccattt gcgatatttg 1303201 gaatcgcagg cttactgatc gctggcgcaa gagaaagaag aagattatct gtagagcaga 1303261 aggaaacggt gttctgggtt gcgtggcttg taccgattgc cggattcttc agtgtcgcag 1303321 aatttttcca tcattattat ctcatcatgc tggcaccgcc gattgcggct cttgtcggtg 1303381 cggggtgggt cgctcttgtt catctgtacc gcaatcagac aggctggaaa gcatggcttt 1303441 tgccgggagc aattattgcg acaactggat ttgaattgtt tattctcaga aactacaacg 1303501 atcaaatcgg tgttggatgg agtatcgggg taggtgttat cggcgtgttg tcagcgattg 1303561 ctttgctgct gtttaaacag cgccaaaaac cgttcagtta ttatgtttca cttgcagctc 1303621 tcctcgcatt gctggtgatg ccgatgtatt gggcaagtac accgcttctg tacggaggca 1303681 acagctcact gcctgaaaca ggccctcaac tcgcatcaat gagcggaaaa ggcatgggaa 1303741 tgtctgatgc gactgtaaat gaaaaactga tcaaatatct agaggagaat aactccggag 1303801 ctgaatacct attcgccaca accgattcga acacagcggc accatatatc attaaaacga 1303861 aaaaagctgt catggctatt ggtggataca gcggttctga cccggcaatc acactgactc 1303921 aattcaaaaa acttgtaaaa gaaggaaaag tgaaatactt cttggcttct ggaatgggaa 1303981 gaggcggaaa caatgacatt gttgaatggg ttgagaaaaa tggaaaagaa gtagcatcag 1304041 aaaaatggca atcaagttct gatcaaaaaa cagaaaatac tgattcagct gatacatcaa 1304101 gcagcaaggc ttcaggtgaa aacggcaaaa tgggcggacc tggcggaatg aatcagtcag 1304161 caacattata cgaactacat gctgatgaat aggaggcaaa aacatgagca gacatattca 1304221 atattcaatt gttgtacctg tgtataatga agagcttgtc attcatgaaa cctatcagcg 1304281 cttaaaagag gtcatggatc aaacgaagga aaactacgag ctgctttttg tcaacgatgg 1304341 cagcaaagac cgcagtattg agattttaag agagcacagc ctgatcgatc cgagagtgaa 1304401 aattattgat ttttcaagga attttggaca tcagatcgcc attacggcag gtatggatta 1304461 tgcacagggg aatgcaatcg tcgtcattga cgccgatttg caggaccctc ctgaactgat 1304521 tttagaaatg attgaaaagt ggaaggaagg ctatgaagtc gtgtacgccg tacggactaa 1304581 acgaaaaggg gaaacctttt tcaaaaaaca aaccgcggct atgttttacc ggcttctcag 1304641 cggtatgaca gatattgata tcccgattga tacgggggat tttcgcctca tggacagaaa 1304701 agtctgtgat gaaatgaaga gattaaaaga aaaaaatcca tttgtaagag ggctagtcag 1304761 ctgggtgggt ttcaaacaga cagcggtcga gtatgtacgt gatgaaaggc tcgccggaga 1304821 aacaaagtac ccgctcaaga aaatgctgaa gctgtcaatg gacggcatca cgacattttc 1304881 acataaaccg ctgaagctgg caagctatgc ggggatttta atgtcaggta ctggatttct 1304941 gtatatgttt atcgtgctgt atctgaagct attcacagac agcacgatta ccggctggtc 1305001 atcacttatt gtgatccagc tcctgttcag cggcattgtc cttctgattt tgggcgtgat 1305061 tggcgaatat atcggcagaa tctacgatga agccaaagac aggccgcttt acatcgtcca 1305121 aaaatcgtat ggaattgaaa ataaaagact ctatagagac cagcatatgt cataacctca 1305181 aaccccctgt ccgtaatgga cagggggttt ttatgctctg agcacgatct aaagcaaaag 1305241 atgctgatag atatatggaa attgggtaaa gaagagattg tgagcttgta ctgcggttca 1305301 gtcatgctga aataaaaaca gcaaaactta aagatttcgt cctcggcttt gctgcatgtc 1305361 agctgttata ttggggggct tttaagaaac gcatgattag agccgtacca gttatgttta 1305421 atagaatact cgtacccaat acaattcccc acgtcaacgt cgattcagag agaagaaagc 1305481 tcagcaaaag aaaagccaat cctgcgcaga tcatacccag tcccacggtt ttcatgttca 1305541 tgcctcctag caaacgatgt ttctagcatc tgatgtgaat gatgtcaatc tgtatgatat 1305601 acggatatct cgtcagaaag tttcatagaa caattaggtc ttttatctaa taaaaagcct 1305661 cagaccgctt ttacggcctg aggcattatg tcttacgaag ttttctcttc tttttgatcc 1305721 agtttaattt ttttcgtcat ttctttgccg tttcggagaa ttttcacttc aacggtatca 1305781 ccgatctttg cgtctttata taagatattg cgcaattcac tgcctgtatc aatttcttta 1305841 ccttttaggc cgatgataat atcctccgct tttaatccgg ccttttcagc aggagagcct 1305901 gaagcgacct cacggatgta aacgccttta ttcagctggc tgccgaacag gccgagtgtg 1305961 ccttcttggt aattttgcgg cacttgctct agatcaagca tgctgacacc gatatatgga 1306021 cgttcaattt gtcctttaga cagcaattct tcagcaatcg gttttacgtc attgcttgga 1306081 atggcgaatc cgataccctc aacatcatcc tcactgattt tcatactgtt aatgccgaca 1306141 attttgccgt ctgtatttaa caaaggaccg ccgctgttac ctggattaat tgctgcgtct 1306201 gtctgaatga cgttaatgct cgtttcgccg gctgatgtag acattgaaac cgttctgtcc 1306261 acgccgctta caattccttg tgttactgtg cgggacaggt cttttccaag cggatcccca 1306321 atcgcaataa cggtctcgcc tgttctaaga tcagatgaat caccgaagtt tgccactttt 1306381 gtgacgtggt catcactgat ttggaggacg gctaaatcag ttaacgagtc actgcctacc 1306441 agctttgcag taacctcagt gccgtcatat aaagatacct tcagtgatga tgccccttct 1306501 acgacgtggt tatttgtaat gatataagcc ttgccattct cttttttgaa aatgacacct 1306561 gaccctgaac cgctttctgt atcttcgctg gaatcagaag aactagagcc gaacaaagag 1306621 ctgtttgatt gtgcctgaag atttgtaata ccgacaatcg ctggtgaaag gtcttctacc 1306681 atatctgaga ttttagaaga gtcctcgctc ttgaatgcag atgagctgct tgagcttttt 1306741 ttagattcag aggaggtgct tgttgctgta acagattgcg tttgctgctg gctggatgat 1306801 tgttttgcag tgtcctgaga atcatggtca ccaagcggtg taaacgtgta aatgccaaga 1306861 gcaagactgc cgccgatcac tccgccaagc aacggtctga accatccgaa tcctcgtttt 1306921 ttcttctcct gatcatgaat gacattgcgg gccgagtagg aggcgctctg atcgttctct 1306981 ttcgttaaaa agacctcatt ctcattacct ttcgttctgt tttcatcacg atagttatcc 1307041 atcatgttca ctccgtttct ctattttcac atgtctattt atattgatag gtttatgact 1307101 tgagtttatc ataaacaaaa actgtgggat aaaaatgaaa agattatggg aaattgtgaa 1307161 aaagtgcgga aaacggtaca cttcatattg tatatgaaag gactgagtcg atggaacaga 1307221 ttggattgat tggatatggc agcatggcgg atatgatcgc tagacagctg ttgaaacatg 1307281 aacaaataaa agagaatgag ctatttattg agacgagaac gaagggggag cggctgcggg 1307341 cactcatgtc agattatcca aacgtatcgg ctgatccgtt ggagaattgg gcaaatacgt 1307401 gccaattgat tttgatatgc gtcccgccac tccatgtcat cgaaacaatg cgccgtctgt 1307461 acccgtatgt gaacagaaat actcacatcg tatccatagc tgccggtgtg ccgctgcgtc 1307521 ttttggaggc agaaacagaa gccggtatct cacgtgttat tcctgccatt acgtccgaag 1307581 cagaagccgg catctcactt gtcgttcaca gtgaagcact ggctgcagag aaaaaagaac 1307641 gtctgaatga attgttatcg gttttcagcc gtgtacggga aatcaaagaa tcgaatttag 1307701 atgtggccag caatttaacg agctcggcac cgggattcat agctgcaatc tttgaagaac 1307761 tggcactgtc tgccgtcaga aacagcagcc tgtccaaaga agaagccttt gattttctga 1307821 ttcattcgct atacggaact ggcaagatgc tgatcgaaaa aaatatgtct ttcgaggaga 1307881 cgctggaacg tgttgcaacc aaaggcggaa taacgggaga gggagctgag gtgatacacg 1307941 cctctgtgcc ggacgttttt gatgaggtat ttgaaagaac cctgagaaaa tatgaactgc 1308001 ttacagaaca ggttggtaaa caaacatgaa tccttgaaag aggattcttt ttttatcact 1308061 gaatgattga gatttttccc agttatattg catttttcct ctttttttaa tataatttgt 1308121 tagaatattc ataatttagt aaaaaaggag gagcgttatg aaattgtaca tgtcagtaga 1308181 tatggaaggt atttcgggtc ttccggacga tacctttgtg gattccggca agcggaatta 1308241 tgaacgcgga cggcttatca tgactgaaga agcaaactac tgtattgctg aagcgtttaa 1308301 cagcgggtgt accgaggtgc tggtcaatga cagtcattcg aagatgaata atctgatggt 1308361 tgaaaagctt caccctgaag cagacttgat ttctggtgac gtcaaaccat tttcaatggt 1308421 ggagggactg gatgatacgt ttagaggcgc tttgtttctc ggttatcatg cgagagcctc 1308481 gactcctggt gtcatgtcac acagcatgat tttcggcgtc cgtcattttt acataaacga 1308541 tcggcctgtc ggtgagcttg gattaaatgc atacgttgcc ggttattatg atgtcccggt 1308601 attaatggta gccggggatg accgggcggc gaaggaagca gaagagctta tcccgaacgt 1308661 gacgacagcc gcagtcaaac aaaccatttc aagatccgca gtgaagtgct tgtcgcctgc 1308721 gaaagccgga cggctgttga cagaaaaaac cgcatttgcc ctgcaaaaca aggacaaagt 1308781 caagccgctc acaccgcctg acaggccagt tctgagcatt gaattcgcca attatggcca 1308841 agcagaatgg gcgaatctga tgccgggaac ggaaatcaag acgggaacta caaccgttca 1308901 atttcaggcg aaggacatgc ttgaagccta tcaggcgatg cttgtcatga ctgagcttgc 1308961 gatgcggaca tcattctgct aaaggggtgt tttaggcttt ggcgcgatac atgataaagc 1309021 gtttttgggc aatggcagct acgattttgg tgattaccac cctgactttt gttctcatga 1309081 aggtcattcc cggatctcct tttaacgagg agagaggcac aaatgaagcc gttcaaaaaa 1309141 atctcgaagc ctactatcac ttagacgatc ctctcatttt ccaatacatt ttctacttaa 1309201 aatccatcat tacattcgat ttcggacctt caattaaaaa accgtcggac agcgtaaatg 1309261 atatgctgga acgcggattt cccgtttcct ttgagcttgg gatgacagcg attgtcattg 1309321 ctgtgatttc tgggctggtg ctgggcgtaa tcgctgcact ccgccgcaat ggctttttgg 1309381 actacgccgc gatgagtctt gcagtactcg gcatctccat cccgaatttt attctggcaa 1309441 cattgctcat tcagcaattt gctgtcaatc tcaaactatt tcccgctgcg acatggacga 1309501 gcccgattca tatggtgctt ccgaccgcag cgcttgctgt agggccaatg gcgatcattg 1309561 ccaggctgac acggtcgagc atggtcgaag ttctgacaca ggattatatc cgcacagcaa 1309621 aagcaaaagg gctttctccg ttcaaaatta tcgtaaaaca cgcactcaga aatgcactca 1309681 tgcccgtcat taccgtcctg ggcacactcg tcgccagcat cttaacagga agctttgtca 1309741 ttgaaaaaat ctttgccatt ccgggaatgg gaaaatattt tgttgaaagc attaatcagc 1309801 gggactaccc cgtgattatg ggaacgaccg ttttttacag cgtcattctg attatcatgc 1309861 tgtttttggt cgatttggcc tacggtctct tagacccgcg cattaaactg cataagaaag 1309921 ggtgaagcgt gtgaatctcc ctgtacaaac ggatgaacgc cagccagaac agcacaatca 1309981 ggtgcctgat gagtggtttg tcttgaatca ggaaaaaaat cgggaagccg attcggtcaa 1310041 gcggccgagt ttgtcataca cgcaggatgc ctggaggagg ctgaaaaaaa ataaattagc 1310101 gatggccgga ctctttattc ttttatttct ttttgtcatg gcagttatcg ggcccttttt 1310161 atcgccccat agtgtcgtac gccaatcgct gacagaacaa aatcttccgc cctcagccga 1310221 tcattggttc ggcaccgatg aactcggccg ggatgtgttt acccgaacat ggtatggcgc 1310281 gagaatctcg ttgtttgtcg gcgtgatggc agcactgatt gattttttga tcggtgtcat 1310341 ttacggaggc gttgccggct ataaaggcgg caggattgac agcattatga tgcggattat 1310401 cgaagtgctg tacggactgc cgtatctgct tgttgtcatt ttgctgatgg tgctcatggg 1310461 accgggactg ggcacgatta ttgtggcgct gactgtgacc gggtgggtcg gcatggcgag 1310521 aattgtaaga ggccaggtgc ttcagattaa aaattatgaa tatgtactcg cctcgaaaac 1310581 ctttggcgcg aaaacctttc gcatcatccg gaagaatttg ctgccgaata ctatgggagc 1310641 gatcatcgta caaatgacat taaccgtacc tgccgccata ttcgcagaat catttttaag 1310701 ctttctcggc ctgggcatac aggctccgtt tgcaagttgg ggcgtgatgg cgaatgacgg 1310761 cctgcctacg attttatctg ggcattggtg gcgcctgttt tttccggcct ttttcatatc 1310821 tctgacgatg tacgcgttta atgtgctggg ggacggattg caggatgcgc ttgaccctaa 1310881 gctgaggagg tagctgtatg gaaaaagttc tgtcagtcca aaatctgcac gtgtctttta 1310941 cgacttacgg cgggacggtt caggcggtca gaggggtgag ctttgatttg tataaaggag 1311001 aaacctttgc gatcgtcggc gaatccggct gcggcaaaag cgttacctcc caaagcatca 1311061 tgggcctgct tccgccttat tcggcgaagg tgacagacgg caggattcta tttaaaaaca 1311121 aagacctttg ccgtctctct gacaaagaaa tgagaggtat aaggggagcc gacatttcta 1311181 tgatttttca agacccgatg acggcgttaa accctacgct gactgtcggc gaccagctgg 1311241 gggaagcgct attgcgccac aaaaaaatga gcaaaaaagc ggcacggaaa gaggtgcttt 1311301 ccatgctgtc attggttggt attccagatc ccggagagcg cctaaagcaa tatccccacc 1311361 aattcagcgg cggtatgaga cagcggattg tcattgcgat ggcgctgatt tgcgagcctg 1311421 atatcttaat tgcggatgaa ccgaccaccg ccctggatgt aaccattcag gcacagattt 1311481 tagagctgtt taaagagatt cagagaaaaa cggatgtgtc tgtcattctg attacgcacg 1311541 atttaggggt tgttgcccag gtagctgaca gagtcgcagt catgtatgcc gggaaaatgg 1311601 cggaaatcgg cacaagaaaa gatatttttt atcagccgca gcacccatat acaaaaggcc 1311661 tgctgggctc tgtcccgcgg ctggatttaa atggcgctga gctgaccccg attgacggaa 1311721 cgccgccgga tttattttcg cctccgccgg gctgcccgtt tgccgcccgc tgtccgaaca 1311781 ggatggttgt gtgtgacagg gtgtacccgg gccagacgat cagatctgac tcgcacaccg 1311841 tcaactgctg gctgcaggat caacgagcag agcatgcggt gctgtcagga gatgcgaagg 1311901 attgaacatg aaaaggggga agaggatgaa acgagtgaaa aagctatggg gcatgggtct 1311961 tgcattagga ctttcgtttg cgctgatggg gtgcacagca aatgaacagg ccggaaaaga 1312021 aggcagtcat gataaggcaa aaaccagcgg agaaaaggtg ctgtatgtaa ataatgaaaa 1312081 tgaaccgact tcattcgatc cgccgatcgg ctttaataat gtgtcatggc agccgttaaa 1312141 taacatcatg gaggggctga cgcgtcttgg caaagatcat gagcccgagc cggcaatggc 1312201 ggagaaatgg tctgtttcga aagataataa aacttacaca tttacgattc gggaaaatgc 1312261 gaaatggaca aacggagatc ctgtaacagc cggagacttc gaatacgcgt ggaagcggat 1312321 gcttgatccg aaaaaaggcg cttcatcggc attcctaggt tattttattg aaggcggcga 1312381 agcatataac agcgggaaag ggaaaaaaga cgatgtgaag gtgacggcaa aggatgatcg 1312441 aacccttgaa gttacactgg aagcaccgca aaaatatttc ctgagcgttg tgtccaatcc 1312501 cgcgtatttc ccggtaaatg aaaaggtcga taaagacaat ccaaagtggt ttgctgagtc 1312561 ggatacattt gtcggaaacg gcccgtttaa gctgacggaa tggaagcatg atgacagcat 1312621 cacaatggag aaaagcgaca cgtattggga taaggataca gtgaagcttg ataaggtgaa 1312681 atgggcgatg gtcagtgaca gaaatacaga ttaccagatg tttcaatcag gggaacttga 1312741 taccgcttat gtccctgctg agctgagtga tcagctgctt gatcaggata acgtcaatat 1312801 tgttgaccag gcgggtctct atttctatcg atttaatgtc aacatggagc cgttccaaaa 1312861 tgaaaacatc agaaaagcct ttgcgatggc tgtggatcaa gaggaaattg taaagtacgt 1312921 cacgaaaaat aatgaaaaac cggcgcacgc ctttgtatcg cctgggttta cgcagcctga 1312981 cggcaaagat ttccgtgaag caggcggaga cctgatcaag cctaacgaaa gcaaagcgaa 1313041 gcagctgctc gaaaagggca tgaaggaaga aaactataat aagcttcctg cgatcacgct 1313101 tacttacagc acaaagccgg agcataaaaa gattgccgaa gctattcagc aaaaattgaa 1313161 aaatagcctt ggagtcgatg tgaagctggc caatatggaa tggaacgtat ttttagagga 1313221 tcaaaaagcg ctgaaattcc aattctctca aagctcattt ttgcctgatt atgcagaccc 1313281 tatcagtttt ctggaagcct ttcaaacggg aaattcgatg aaccgcacag gctgggccaa 1313341 taaagaatac gatcagctga tcaaacaggc gaaaaacgaa gccgatgaaa aaacacggtt 1313401 ctctcttatg catcaagctg aagagctgct catcaatgaa gcgccgatca ttccggttta 1313461 tttttataat caggttcacc tgcaaaatga acaagtaaaa ggaattgtcc gtcaccctgt 1313521 cggctatatc gatttaaaat gggcagataa aaactgatgg aggcgattga ggaaatactg 1313581 cttctttatg cgaaggagcg gtattttttc tctttcttgc acgtatacgt agggtgcaga 1313641 gcaaatgaaa ggagtgtttt cgttgaatta caagccgaaa gcgttgaaca agggtgatac 1313701 agtcggagtg atcgcgcccg caagtccgcc ggatccaaaa aagcttgaca ccgcgctttt 1313761 atttttagaa gagctcggtc ttcaggtgaa gttgggcaag gcgctgaaaa accagcacgg 1313821 ctatttagcg ggacaggatg atgagcggct ggcggatctc catgagatgt tcagagacga 1313881 tgaggtaaaa gcagtgttgt gcgcatgcgg gggttttggg acaggacgta tcgccgcggg 1313941 cattgatttc agcttgatcc gcaaacaccc taaaatcttt tggggataca gcgatattac 1314001 gtttttacat actgccattc atcaaaacac aggtcttgtc actttccatg gcccgatgct 1314061 cagcacggat attggccttg acgacgttca cccgctgaca aaagcgtcat ataagcagct 1314121 cttccaggag acggaattca cctatacaga agagctttct ccgctgaccg agcttgttcc 1314181 tggaaaagcg gaaggcgagc ttgtcggggg aaatctgtct ttgctgacgt ctacactggg 1314241 cacgccattt gaaattgata cgagaggaaa gcttctgttt attgaagata ttgacgagga 1314301 gccttatcaa atcgaccgga tgctgaatca gctgaaaatg ggggggaagc tgacggacgc 1314361 ggcgggaatt ctagtttgtg attttcacaa ttgtgtcccg gtgaagcgag agaagtctct 1314421 ctcgcttgag caggtgctgg aagactatat tatttctgcg ggcaggcctg ctctgagagg 1314481 atttaaaatc ggccactgct cgccaagtat tgccgttccg atcggtgcga aagctgctat 1314541 gaatacagca gaaaaaacag ccgtaataga ggcgggcgtt tcagaagggg cgctgaagac 1314601 atgaaaatca ttcgaatcga aacaagccga atcgctgtcc cgctgacaaa gccgtttaaa 1314661 accgcacttc gcactgtgta tacggctgaa tcagtcatag taaggattac ttatgacagc 1314721 ggtgcagtcg gatggggaga agcacccccg acgttagtga ttacaggaga cagcatggat 1314781 agcattgaaa gtgccatcca ccatgtgttg aagccggcat tgcttggaaa aagcctggcg 1314841 ggctatgagg ccattctgca cgacatccag catcttctta caggaaatat gagcgcgaag 1314901 gctgctgtag aaatggctct atacgacggc tgggcgcaga tgtgcgggct gccgctttat 1314961 caaatgcttg gcggatatcg agatacgctg gaaacagatt atactgtcag tgtcaactca 1315021 cctgaagaga tggcagctga tgccgagaat tatctcaaac aaggctttca aacgctgaaa 1315081 ataaaggtcg gaaaagatga tattgcaaca gatatcgccc gtatccagga aatcagaaaa 1315141 cgtgtcggat cagctgtgaa actgcgttta gacgctaatc aggggtggag gccgaaggaa 1315201 gcggtaactg ccattcggaa aatggaggat gcgggcctag gcattgagct tgtcgagcag 1315261 cctgtccata aagatgatct cgctgggctt aaaaaggtga cagatgcaac agatacgccg 1315321 attatggctg atgaaagtgt ttttacaccg cgccaggcgt tcgaagttct gcaaacccgg 1315381 agcgcagact tgatcaatat taaattgatg aaagcgggcg gcatcagcgg agcagagaaa 1315441 attaatgcca tggcggaggc ctgcggggtg gagtgtatgg tcggcagcat gatcgaaacg 1315501 aagctgggca ttacggccgc ggcgcatttt gcggcaagca agagaaacat cacacgcttt 1315561 gattttgacg cgccgctgat gctgaaaaca gatgtattca atggcggcat aacatatagc 1315621 ggcagcacga tttcgatgcc tggcaaaccg ggcctcggaa tcatcggggc tgcgcttttg 1315681 aaaggggaaa aagagcaatg atgcacactg tcatatcagc agtggccaac atctggacag 1315741 cgcctgattc acctcgtccg tctgatcaat tcatgcttca accgactgta atgatcagag 1315801 actggctgga gcgcatgacg tatgatgaac ggcttggatt atgtacagac aatgtaatcc 1315861 aaactcaggt tctctttggc gaaaaggtac ttgtgacggc ggaacagggg gaatgggttt 1315921 ctgtgatcgt gcctagccag ccatcccgaa aggatccgcg cggatacccg ggctggatga 1315981 aaaagtacca gctggaaaaa acaaagccca tccatacaca acacgatgtg atgatcagca 1316041 aacctgctgc ctttttgtac agaagcaatg gggaaaagga gatcgaatta agctttttga 1316101 cagttctgcc ccttattgca aaagaaaacg gatattttaa ggtttcgacc gtttttgggg 1316161 aaaggtttgt gaggcaaagt gatgcagtgc ctgtcagcca acagaaaggg actgctgaag 1316221 acatcattca aacgggtgcg ttttttcttg gccttcccta cctgtgggga gggatcagcg 1316281 ggtttgggtt tgattgctcc ggatttatgt acagtatatt taaggcgaat ggatacagca 1316341 tcccccgtga tgcgggagat caggctaagg cagggaaggg tgtcccgctt gatgatatga 1316401 aagccggtga tctgctgttt tttgcttatg aggaaggaaa aggagcgatt catcacgtcg 1316461 gtctgtatgt aggcggcggg aaaatgcttc attctccaaa gacagggaag tcaatcgaaa 1316521 tcctcacatt aacagagaca atctatgaaa aagaattatg tgcggtgcgc cgctgttttt 1316581 cagaataagg agggagacaa atgaggcgac tgcctttgtt agaggtcagc cagctgaaaa 1316641 tgcattttga cgcagggaaa aagcggacag tcaaagctgt cgacggggtc acctttcaga 1316701 ttcgtgaagg agaaacgttc gggctagtcg gggaatcagg gtgcgggaaa tcaaccttgg 1316761 ggagagtgct gatgcgcctt tatcagccga cagaaggaag cgtgacatac cgcggcacaa 1316821 atcttcatgc actaagtgaa aaagagcagt ttgccttcaa ccgcaaactg cagatgattt 1316881 ttcaggaccc ttatgcttca cttaacccgc gcatgaccgt tcgagaaatt attttggagc 1316941 cgatggagat tcataatctc tacaataccc ataaagcacg gcttctcgtc gtggacgagc 1317001 tgcttgaggc agttgggctt caccccgatt ttggcagccg ttatccgcat gaattcagcg 1317061 gcgggcaaag gcagagaatc gggattgcga gagcactgtc gctgaatcct gaatttatcg 1317121 tggcggacga accgatttct gcacttgatg tctctgttca agcgcaggtg gtcaacctgc 1317181 tgaagcggct tcaaaaagag aaagggctta cgtttttatt cattgcccat gatctttcga 1317241 tggtgaagca tatcagtgac aggatcggtg ttatgtactt aggacacatg atggaaatta 1317301 cagagagcgg caccttgtat cgtgaaccgc tccatcccta tacaaaggcg cttttgtcct 1317361 cgattccgat tccagatcct gaattggagg acaagcgtga gcgtattctc ttgaaagggg 1317421 agctgccgag cccggtcaat ccgccaagcg gctgcgtgtt tcgtacccgc tgtccggagg 1317481 cgatgcctga atgtggagaa tctcgtcccc agcttcaaga aatcgaaccc ggccgttttg 1317541 tcgcttgcca tttgtatcga aatgctgaaa cgaaggaaaa agtaagataa ataaaaagag 1317601 tggctccttt ttactagagc cactccattt gtttatactt gatgtaaaaa ctttacacaa 1317661 accgggtaag ggacagaaac cgttgatggg aggagtgtca atcggccggt ttctttgtct 1317721 ctttcaaaca agacaaggtt gcctgtttct tcatttgaag caacgaggaa cccttccgtt 1317781 gggtcaaata caaagtcacg aggccagttt ccttctgtcg acactctttc tacgaaagcc 1317841 agctctcctg aatattgatt cacttcaaat acggcgatac tgtcatggcc gcggtttgcg 1317901 acataaacaa aacgtccgtc ctgcgtgaca tgtattgcgc ttccctggct gttatctgta 1317961 aaatcatcag ggatggcaga aacgacttgg atttctctaa attcgccggc tgtcgggttg 1318021 tattcaagcg caatcacttc attgcttaat tctgtcatga cataagcgta tttttctttc 1318081 ggatgaaaag cgatatggcg aggtcctgca ccgggagcga aggaatggct tccggattca 1318141 gtcaacacac cgtctttaag cttataggtg tagagcttat ctatacctaa atcaaccgct 1318201 accacataat tgtgttcagg tgtgaacccc gcgtagtgtg tatgcggttt ttcttgtctt 1318261 tcgtgcggcc cttttcctgt gtgagcggcc tctgaaacag gtgattgcaa gctgccgtct 1318321 tcctgaaccg gaaaaacgtg taccttcccg ctgtgataat tggcagtcag tacgaattga 1318381 ttttgatcat caacgcttac gtggcatggc gaagggccat caattaactg atgattcaga 1318441 aatgtcaatt cgccgctgtt tttatcgatt tgataggcag caactccgcc ttggccgtct 1318501 gctttttcga tggaataaag gatggtgttg tttttattcg tcgccacata tgtcgggttg 1318561 cccagcttag cggccagctt tggctcgctg agtgcttttt tctcagtatc aagctcaaat 1318621 gaataaattc cttcgcttcc gccttttgta tatgttccca catatcctat gtattttgtc 1318681 atgcgatttc ccccttaaaa atgatgtcac ctctatatta acgtatcttg ataaaataag 1318741 ctgttcaaaa catgaaaaag gggaagattc ttcattcgcc tcgaatcagc ggcattgtgc 1318801 agcacctgaa ggagccgcct gatttaataa tttctgacag gtcaatttcg ataatgtgat 1318861 agcctctttt cgatagctgt tgattgacat ggcggttgcc agggagactg atgatcgttt 1318921 tttttccgat tgaaaggacg ttggtgccaa gcgtaaattg ttcgtcctcg ggcacctcaa 1318981 taagatcata acgttttgcc agcatatcgg ctgcatctgg ctcaatggcc tgtgaataaa 1319041 ttaacgcttc gctttcagat ataatgttaa atacgcagtc caaatgcaaa aatttttcat 1319101 gaagcttcac tggaacgatc gtatattcag gaagtgcctc ttctagctgg ccgatagctg 1319161 aaatgtcggt gcgctggctg attccgacat agacaatgtc atcatcgata atgacgtctc 1319221 cgccttcaat actcgtatca agcatgcggg tgtaagagat accttggctg tgaaaaaaat 1319281 cttttataac ggcttcttct ccttggcgaa tcggttcagt catgcttgac agaaaggctt 1319341 tttctccgat gacaaatcct atgtccctag taaaaacctg ttctgggagt ccgtcgcgaa 1319401 cgggcaaaag gacgacctca acgttgtgtg acctaagtgc ctccactaag cggctgtgct 1319461 ggtcgttagc ggtttttaca tgaatattgt catcttcaaa atgtttttgt gtttcgttta 1319521 taacatcttt tatggtcatg tgctcaggtt tgcataagat cactttttga agtgtgccgt 1319581 attccgttcg gcataccgtt ttgtgctgag atttcgggat ggatacgtcc atttgttttt 1319641 cctcctaaag tgtgaagaat acatttatta ttccctcatc atgaaaatca ttaaaccatt 1319701 ttaaatttta gacaaatgga agagaatatt gtttaatagg agaatataag tgcatttagc 1319761 taaaagatca gacatcaaag gggagaaagg tatggaaaca ccggaaacaa gattttgtaa 1319821 agagtcaaag gttgtgaaaa ccagcagggt gttcccgctt gacacgaaca accataatac 1319881 gctgtttggc ggaaaattaa tgagctacat agacgacatt gcctctattt cagcggcgcg 1319941 ccattgcaga cgtgaaacgg taacagcttc aatggattct gtagattttt taaagccgat 1320001 cgggcaaaag gattctgtct gcctagagtc atatgtgaca tgggtcggca catcttccat 1320061 ggaagtattt gtgaaagtta ttaaggagca tttgatgact ggcgaacggg aactcgctgc 1320121 cacatccttt ttgacatttg tcgcattaga ttcaaatggc aagccggtgc ctgtaccgag 1320181 ggttgtaccg gaaacagaag aagaaatcat gctgcataat acagctgtac agcgtgctaa 1320241 tgaacgtaag aaccgcaaga gacacagcca ggcgcttgca aatgcgctcg gaactgataa 1320301 gccttggtga acgttaaacc caaaacataa gttgttttgg gtttttttgt acttttcaat 1320361 ggtgattatt acaatggtta gtccgttttt gctaggggat tctataaaaa agcaacaaat 1320421 gtcatgttaa attgataatt ttgtgacaac tttattaaag attcatttta gatatatctt 1320481 ttattcgtaa gatcatgtat tttaaagata tattttaaat acatcttttc gaaaggattg 1320541 tttataaaat gttagataac aaaacaatcg aaattattaa aagcactgta cccgtattgc 1320601 aacagcatgg agaaacaatc actggccgtt tttacgatcg gatgtttcaa gaccatccag 1320661 agcttttgaa catttttaat caaacaaacc aaaagaaaaa aacacagcga actgcactgg 1320721 caaatgccgt tattgcagct gcggcaaaca ttgaccaatt aggaaacatc attccggttg 1320781 tcaaacaaat cggccacaag caccgcagta tcggaattaa gcctgagcac tacccaatcg 1320841 tcggtaaata tttgctgatt gcgattaaag atgtattggg agacgctgca actcctgaca 1320901 ttatgcaggc atgggaaaaa gcgtacggag tcattgctga cgcgttcatc ggaattgaaa 1320961 aagacatgta tgaacaggct gaagagcaag ccggcggctg gaaggagtat aagccattcg 1321021 ttatcgcaaa aaaagagcgg gaaagcaaag aaattacatc cttctatttg aaaccggaag 1321081 acagcaagcc gttacctgaa ttccaagcag ggcaatatat cagcatcaaa gtgcggattc 1321141 ctgattctga atatacgcat atccgccagt acagcctgtc tgatatgccg ggaaaagact 1321201 attatcgaat ttcagtgaag aaagatggtg tcgtgtcttc ctacttacac gatgggctgc 1321261 aggagggaga ttcaatagag atcagcgcac cggcagggga ctttgtttta gatcatgcat 1321321 cacaaaaaga tctcgttttg atcagtgccg gagttggcat tacaccaatg atcagcatgc 1321381 tgaaaacatc tgtttccaaa cagcctgaac ggcaaattct gttcattcat gcggcgaaaa 1321441 acagtgaata tcatgcattg cgccatgaag tagaagaagc agcaaaacat tctgctgtta 1321501 aaacagcatt tgtgtatcgc gagccgacag aggaagaccg tgcaggtgat ctgcattttc 1321561 atgaaggaca gattgatcag caattcctca aagaactgat tgccaacaca gatgcggatt 1321621 actatatttg cggttcaccg tcgtttatta cggcaatgca taagcttgta tcagagctcg 1321681 gatcagcgcc ggagtctatc cattacgagc tattcggccc gcaattaagt ttggcgcagt 1321741 ccgtttgaac acatacatga aactcttctc ctttcagaga agagtttttt attgagatat 1321801 aagaaggcag acaagcgccg gtttctacat ccggacaatc acagacccgc tgccatttgt 1321861 gcatacacgg ttttgctgtt cttgcattgt tctcagcaat tcattgttta cctcaatcgc 1321921 tctaattagt tgcttcattc ttagctccaa accggccagc ctgtcgattg tttgctgctg 1321981 gtagccctcg ggttggggag ccaatggcag atcaaagggc caaagggtat tcgacttctg 1322041 atttttcata ttgcgtattg cgcctccaat cggtgtcact ttctattatg ttatgttcag 1322101 gcgatatgca cgttcgccta gacactgatg catagagggc ctgccacggg gcacaatagg 1322161 ctcaatatga ccagcggatg gaggtaaaga tcggtgttat ggatggtatg ggtattttta 1322221 ctgaagccag ttatcgtatt ttcgattgca tatattttgt ttcggcttgc cggtaaaaaa 1322281 gctgtgtcac aaatgaacaa ttttgacctg cttttgacct tcgcaatcgg aaccattatc 1322341 agtgagccga tccttacatc caagctgccg atgtcaattt attatgcggg tgcttttttg 1322401 gtgctttatc ttatcatgag caagctctct ttatctaata aatggcgatg gctcctagtc 1322461 gtgagcccga ctgtcctaat ccgaaacggg gatattgatg aacgcggcct tcgtaaagaa 1322521 aggctgactg ttaatgagct gctcggaaag ctgagggaaa agggctatgc cgacccggct 1322581 gacattgatc ttgctatcat tgaagaaacg ggagaagtaa gcgtcatccc gaaagaggaa 1322641 gcgagagcgg tgcaggtgcg ggatttgaat atggaagctg aacggaattt tatcccgatt 1322701 ccgctcatac tggatggcga aatccttgat cataatttga aatatctcca aaaaaaccga 1322761 tcctggctgt ttgagaagct tgaggaaaaa gggtacagcc ccaaactgct gtcttcgatt 1322821 atccttggca cgatgaatgc acgcggtgat atatcccttg atttaaatac cgctaatgaa 1322881 ccgcagcatg atccttactt atataaaccg ggaaataaca attaagatgg ctctctcttg 1322941 taatgagagc ttttttcttt tttaaaggga atttttgttt ggtgtcaaat gtacctagtt 1323001 aggaggggaa ctgaacatga aggacttatc cataagaaac gacatggcgc caacggtcag 1323061 tttgctgtat tccgcagtgg aagaaaacag tctccgtctg gcttccatcg taagccatat 1323121 gacacacagt gaactttact ataaggggcg ctgccaaaca aaaaacagca cggctcagct 1323181 tttgcaccat atcacaaatg ttgatatcag atgggtctgg cgtatcaagg aaaatcggat 1323241 cccggaccat attgaacagg catacggccc gatgacagat gaaagcggac ggctgcctga 1323301 accggtgaat cagccagact tagatgaact cctgaaaaga catcagcatg tagtagagaa 1323361 gctgaaatcg gtatgcttca ctttaactga aaatgctttg aaccagccgc tttccttcga 1323421 aggtgacacc gcgacgatac gatggggaat ttggcatatg gcagatcata accgctatca 1323481 tcaggcacat attgaagctc tcaaaaaaga atggaagcag gatgtggcga agtatgaacg 1323541 ctaaaacgaa gcttgtgact gatcgaattc gtttgcgctg tatggaagat cgggatcaag 1323601 ccactttgtt tgggctgctt tttaatgatc ctgacgtcat gacatattat tccggtttaa 1323661 aagataagag gcaaacccgc gagtgggtca attggaacca acgaaatgaa aaagggtacg 1323721 gcgttagtct gtggatcgcc gaagataagc ggacagggga gtttttgggg caatgcggca 1323781 tcgttcccca gcagatcgaa aatcaaaccg taatggaaat tggctatatg tttgcccgcc 1323841 gccactgggg gaacggctat gcgcaagaag cggctcgggc ctgtctggac tatggcttta 1323901 acgagcggca gttcggcaaa atggcggctt tgattgatcc gggtaacaaa gcgtccatac 1323961 gggtagcgga gaaaatcggc atgcattaca gcaaaacgat cagaaaatgg aataaaccga 1324021 tcgcggtata tgaaagaaaa tcttacaatt gaaagataga gctgagttta gtatcatgat 1324081 atcatgtaaa gttttctagg gttccgcatg tcaattgaca tggactggtc cgagagaaaa 1324141 cacatacgcg taaatagaag cgcgtatgca cacggaggga aaaaagcccg ggagagtcaa 1324201 tctcatgtga gacgactgtc cggggttttt ttgttttcgg agaatcttaa tagatagaaa 1324261 ggaatgactc aaaatgaaat ggggattggt cgtgcttgcc gctgttttcg aggttgtttg 1324321 ggtgataggc ttaaagcacg ctgactcagc cttaacatgg agcggcactg ccatcggcat 1324381 catattcagc ttttaccttc taatgaaggc gactcacagt ctgcctgttg gtaccgtgta 1324441 tgccgtcttt accgggctcg gcacagcggg aacagtactt agtgaaatcg ttctttttca 1324501 tgaaccggtt ggatggccga agctattgtt aattggcgtg ctcttaatcg gtgtaatcgg 1324561 gttgaagctt gtgacacagg atgagacaga ggaaaaagga ggcgaggcat aatgctgcac 1324621 tggatcagtt tattgtgcgc gggctgttta gaaatggccg gcgtggccct tatgaatcaa 1324681 tatgcgaaag aaaaaagcgt gaaatgggtg ctgttgatca ttgttggttt tgccgcttca 1324741 ttttccttgc tgtcgtacgc aatggaaacc actccgatgg gaacggctta cgcggtctgg 1324801 acaggaattg gcaccgccgg cggggcgctt atcggcatcc tcttttacaa ggagcagaaa 1324861 gacgccaaac ggatcttctt tatcgcgttg attttatgct cagcagttgg tttaaaaatt 1324921 ctgtcataaa ttgattttta tcaaatcttc agtataatgg ataaatagtt tagacttaca 1324981 aagataagag ggattattca tgaaatcata tatgactcag cggttggacg aataccgtga 1325041 cggaaatgag gataaaggtc ggctcttggt cagctgcccc gatcagccgg gtatcgtctc 1325101 tgcagtttcc gcgtttttat ttgaacacgg tgccaatatt atagaatcaa atcaatatac 1325161 gacagaccct gaaggcggcc ggttcttcct gagaatcgaa ttcgactgcg caggcattcg 1325221 tgaaaaaaaa tcatcacttc aggcagcgtt tgcctctgtt gcggaaaaat tcgacatgac 1325281 atggagctta actttggcga gcgaactgaa gcgtgtcgcc attttcgttt caaaggagct 1325341 ccactgcctg catgagctga tttgggaatg gcaaaccggc aacctgatgg cggagatcgc 1325401 tgttgtcatc agtaaccatg aggaagcgag agagctggtt gagcgcctga acattccatt 1325461 ccactatatg aaagcgaaca aagacatcag agcggaagtc gaaaagaagc agcttgaact 1325521 gctggagcag tacgatgttg atgtgatcgt gctcgcacgc tatatgcaga ttctaactcc 1325581 tgattttgtt tcggctcatc cgaatcgcat catcaatatc caccattcat tcctgccagc 1325641 ttttatcggt gcgaatccgt acaaacgggc ctacgagcgc ggcgtgaaac tgatcggtgc 1325701 gacatctcat tatgtgacaa acgatcttga tgaagggccg atcattgaac aggatattga 1325761 gcgtgtggac caccgcgata atgcggaagc gctgaaaaac atcggaagaa caattgagcg 1325821 cagcgtgctt gcccgtgctg tgaaatggca tttggaagac cgtgtcatcg ttcatgaaaa 1325881 taaaacaatc gtctttaact agactgcaag aggcccgcgc aatgcgggct atttttgatg 1325941 acaaaaaacc ttgacaagtg tcttttttct ttgcataata taaaaaaatc attgagcgtt 1326001 gaagaggatt agtaagcaga cctttctgtg acagagagca aaatgaatcg ctgaaacatt 1326061 ttgccgcatg aaacctgccg aacctgcctt ggagtcctag ggggaaaacc taggcgcata 1326121 acctggcgtt acaggagagc ggagcgtgca caagcgcgtt caatcaaggt ggtaccacgg 1326181 aaacccattt cgtccttatg aatcaggatg aaatgggttt ttttattgta gaagagccgc 1326241 ggaggagaat aaatgaaaaa acaaagaata gtagtgaaaa taggaagcag ttcgctcacg 1326301 aatagcaaag gaagcattga tgaggcaaaa atcagagagc atgttcaggc gatttccgtg 1326361 ttaaaaaaag cggggcatga aatgattctg attacctcgg gtgccgtagc ggcggggttt 1326421 tccagcctcg gttatccatc ccgtcccgtt accatcaaag gaaaacaggc ggcggccgcg 1326481 gtcggacaaa cactgttaat gcagcaatat atgaatcaat ttaaacaata ctcactgact 1326541 ccgggacaaa tccttttaac gagaaatgat ttttcgaaaa gagaacggta tcgaaacgcg 1326601 tatgctacga taatggaatt attagagcgg ggcgtcattc cgattatcaa cgagaacgat 1326661 tctacatctg ttgaagaatt gacattcgga gataatgata tgctttctgc gttagtcagc 1326721 ggattgattc acgcggacca gctcatgatt ctcactgaca ttaacggact gtatgatgcc 1326781 aatccaaatg aaaatcctga ggcgaaacga tttgattatt tgccagagat cacgcctgaa 1326841 ttgcttggat atgcaggttc agctggatca aaggtcggca ccggcggaat gaaatcaaag 1326901 ctgttagcca cacaaaccgc gctgtctctg ggagtgaaag tattcattgg aactggcagc 1326961 ggagagcaaa aacttgcgga cattttggac ggcaggggag acggcactta tatcggagac 1327021 aaagaactat cttcggttaa caacacaagg cagtggattc agttccactc gccgatatcg 1327081 ggagaaatta tcattgatgc gggtgccgaa gaggcgatga tccataatgg aagcagcctt 1327141 ttgcccgctg gagttgtggg cgtgaacgga agctttccga aaggggcggt tgtggaagtc 1327201 aggggaccgg gcggcgtgat cggcaaaggc caaactcatt actcctccga ggagattatg 1327261 gaggctaaag gcaaacgcag tgacgaactt gattttgaga aaacgtttga ggttattcat 1327321 aggaatgact gggtcaatgt aaaagactag gaggcggaaa aatgagtgaa gtttctgtaa 1327381 aagcgaagct ggcgaaagaa gcagcagccg aaatgatcat gaaaacaaca gccgagaagg 1327441 atgaggcgct cagcctcatt gcaaacggac tccgcaaaga actggatttt ctcttggcgg 1327501 agaatgcaaa agacattgtg aacggaaaag agaatggttt aacaccggac atcattgacc 1327561 gtctctcatt ggatgagaaa cggatacgcg atatcgcgga cgcggtggag ctcttaatcg 1327621 acttagcgga cccaatcggc gactctcttg aaacgattga aaaagaaaac ggcctgttta 1327681 ttgaaaaaat ccgtgtgccg ctcggtgtcg taggaatgat ttatgaggcg aggccaaacg 1327741 tcacagttga tgcggctacc ctttgcctga agacagggaa cgcggttgtg ctgcggggaa 1327801 gctcctcagc catccacagc aacaaagcgc tcgtcagtgt catttacaga gcacttgagc 1327861 aatcagcgct tccgattcac gctgtgcagc tgattgagga tacgagcaga gagacagcaa 1327921 aagagctctt tacgttaaat gatggcttag acgtattgat tccgcgcgga ggcaagaaac 1327981 tgattgatct cgttgtgaga gaatcaacag ttcctgtatt agaaacggga gcaggaaact 1328041 gccacatatt cattgacgaa acagccaaac cgcaaatggc agaaaaggtt gttgtaaatg 1328101 ccaaaacgca gcgcccttct gtatgcaacg cgattgaatc attgctgatt cacaaggctt 1328161 gggcaagaca gcacggaaaa gaattgctgg accagctgga aaacgcggga gttgaaattc 1328221 gcggtgatga attggtatgt gaacttcatc cttcaagcaa acaagcatca aaagaagatt 1328281 gggaaaccga atttttagcg cctgtcctca gcgtaaagac ggttgaaaac gtccaagaag 1328341 ctgtaaagca tatccaacaa tacggcacca atcattctga agcgatttta actgaaaatg 1328401 acaaaaatgc ggtatatttt caaacggctg tcgatgctgc cgctgtctat cataacgcgt 1328461 caacccgctt taccgacggc tttgaattcg gctacggagc cgaaatcggc atcagcacgc 1328521 aaaagcttca tgcaagagga ccgatggggc ttcctgcact gacttctaca aaatacatca 1328581 ttaaaggaac tgggcaaatc cgtgaatagc ggggtaatgt tcaatgaaaa agcttatctc 1328641 attacgagat aagctttttt atacgcgaaa aattgacatt tcaaatttaa ttgtgtacaa 1328701 tttaattgta taaaatatat tgggggaatg aaaaatgagt cagccattat ttaccgcaac 1328761 tgtttcagcg gtaggaggaa gagaaggaaa ggtcatttca tcagaccgcg ttcttgagct 1328821 tgatgtcgca atgccgggga caccgagagc caagaaatta gaaaaagcga caaatccaga 1328881 gcagctgttt gcagcaggtt atgcagcttg ctttgacagc gccctgcagc ttgtcgcaag 1328941 aacagaacgg gtaaaagtag agacagaggt tacagcaaat gttagcctgt taaaggatga 1329001 agcggaccag ggctataagc tgggtgtgac gctgcaagta aaaggagaag gagtcagtgc 1329061 atcagaattg gaggcgcttg tgaaaaaagc gcacggcgtc tgcccgtact caaaagcaac 1329121 ctccggaaat attgatgtga cacttgaagt tgctgaataa ataaaaagag gatgcctgta 1329181 caaggcatcc tcaatttttt tgatgaagtg tttccagtaa tgtatataga gcggacttta 1329241 actgtttgag atcctcccca gactgctttg agagccccag aattgtccct ggaatgtcaa 1329301 ccgctttttc ttttaataac gctccgtcct ctgtcaggct gatcaacacg gaccgctcat 1329361 cctcttcaga tctttttctc gtaatcaaac cctgttgttc cattcgttta agcatcggag 1329421 tgagcgttcc tgaatctaaa tacagctgtt cgcccatttt tttgacagta agcgtttcat 1329481 gttcccataa caaaagcaaa gccaaatatt gagggtatgt tatattcagc ttatcaagca 1329541 gcggcttgta ttgctttgtc atctcccgcg aactcgcata tagcaaaaaa caaagctgat 1329601 tctccaattt catatgatca aatttatttt ccattttgtt caccaactct tttttgtcat 1329661 tcgattctat tgtatctgaa aaacctcact tttcctattc tcggcaaaca tagcatgttt 1329721 aaaaagatca gaaagggaaa tataacaact agatacaaat aaggaggttg ggaaatatgg 1329781 cactatttac agcaaaagta accgcgcgag gcggacgagc aggacatatt acatcagatg 1329841 acggtgttct tgattttgat attgtcatgc caaatgccaa aaaagaagga caaaccggca 1329901 caaatccgga acagctcttt gcggcagggt atgctgcatg cttcggcggc gcgctcgaac 1329961 acgtagccaa agagcagaat atcgaaattg attcggagat tgaagggcag gtcagcctca 1330021 tgaaggatga gagcgacggc gggtttaaaa tcggtgtcac acttgttgtg aacacgaaag 1330081 atttagatcg ggaaaaggca caagagcttg tcaacgccgc tcatgaattc tgtccttact 1330141 caaaggcaac cagaggaaat gttgatgtaa aactagaatt aaaataatga ccggcatcct 1330201 gaggattctc aggatgtttt ttggtgtcgg acatgcgggg cgggcacaga tttatgataa 1330261 aacttcagag aagcgtttga agcatgcctt taaaccaaaa gttacagatg aagcgggtgg 1330321 ctggcacggt gtctgccgtg ctgaattgcg cgtatatgct gttttgtatt tgcacagggc 1330381 atagcggcta cttggagaaa taacaaggac caggccgcgc atgcctgatc cttttaatat 1330441 tctttcttat tggcgaagtt ccgccatgct tgaaacgggg ataaatgctc tgttagtgtc 1330501 acttgataaa aggggatcgt tctttcttca gcaggtttat caatttcttt ataaatgaat 1330561 gaatcatcaa acccggcttc ggcagcgtct gtgtgctcag ctgcatagaa aacggcttta 1330621 ggccgggccc agtagatggc gcccaagcac attgggcatg gttcacagct cgtatacaaa 1330681 atgcagtcat caagctggta ggctcctagc accttacagg ctttccgaat agctgtgact 1330741 tccgcgtggg cagtcggatc attgcttgtt gtgacgttgt tctgtccctc tgcaataatg 1330801 gctccgtctt tcacgataac ggctccaaaa ggcccgccga ttcctgcatt cactccttca 1330861 catgcgagag tgacagcccg ttttaagaac gtttcatgat tcatcccaat ccctcctgtc 1330921 aatagagtgt tattagtata gccgaaaaga atgcaaagaa cattcttaaa aaagtgcaaa 1330981 ataaacaaag tatttggggg atttgctaaa taagaaaccg attgtggctg tattatagaa 1331041 aaaaaccatc tgccaaatgc agatggtttt ttcaaattat actagctgtg tctgctgtgc 1331101 tcttgcctgt tttgcggctt caaccatatt tttcaatgct gcaaccgttt cttcctgctg 1331161 tcttgttttc aatccgcagt ctggatttac ccagaagcgg tcagtcggac agacggcaag 1331221 cgcatcaacg ataatattgt acatttcttc agttgacggc acacgagggc tgtgaatgtc 1331281 atatacacca aggccaagcc ctttcaaata cgggtggttt tttaagtaat ctaaaaatcc 1331341 tccgtggctt ctgctatgtt cgattgtaat cacatcggca tcaagatcat tgattgtatc 1331401 aacgatatct tcgaagttgc tgtagcacat atgtgtatga atttgtgtct cgtttttcac 1331461 ggaagaagtg gttaatctga aagcttctgc cgcccaagtc aaatactcat cccaatcgcg 1331521 ggttttcaat ggaaggcctt cacgcagcgc tggttcatcg acttgaatga tttgaatgcc 1331581 tgcgtcttca agcgctttaa cttctttgcg aagggcaagc ccgatttgga aggcgatttc 1331641 tttcctcgag atgtcgtttc gagggaaaga ccagtttaag attgtaaccg ggcccgtcag 1331701 cattcctttc acatgcttgg aagtcaatga ctgtgcgtag actgtgtctt tcactgtcat 1331761 cggttcaata aattcaacat ctccgtaaat gactggcggg cggacacagc gtgagccgta 1331821 tgattgaacc caggcatatt tagtgaaggc gaaaccggcc agcttttcac cgaagtattc 1331881 gaccatgtct gtccgttcaa attcgccgtg aacaaggaca tcaagctcca attcttcctg 1331941 aatatcaatc catctttttg tttccgcatt gataaagttt tgatactgtt catcggacca 1332001 ctcagctttc cgccattttt ggcgtgcgct ccgcacttca gcagactgcg ggaagctgcc 1332061 gatcgttgtc gtcggcaaaa gcggaaggcc gagagattca ttttgtaggg ctaaacgttc 1332121 ttcaaacgga atcgggcgct tgaagtcttt atcagttaat tgctcaagct ctttcttttg 1332181 ttcagaattg gcgcctgttg caaactgttt aagcgcctgg atatcagcct tagcctgctg 1332241 aatctcttcg ctgatcgccg cttttcctga tactaagcct tctttcaaag ctgtcagctc 1332301 ggccagcttt tcttttgcgt aggataatcc gttcaatagg tctttttcca aatgctcatc 1332361 agggtgtttc gctactggaa catgcagcag gctgctggaa ggctgaatcc acagttcatc 1332421 aacttttgca atgctgagaa tatcaagaac ggcatcgaga cgctcttcaa ggtccgcttt 1332481 ccaaatgttg cgtccgtcga taacgccggc tgccagcact ttatctgtcg ggaagccatg 1332541 tgttttaagc tgttccaggt ttctgccttt gtcgtgaacg aaatcaaggc caattccctg 1332601 aaccgggtaa gagatcagct cttcataagc atcaacagaa tcaaaatacg tctgcaaaag 1332661 cacattcaag gatgaaagct cacttgtaat gctttcaaat aattcttttg cgccgcgtac 1332721 atcttcacta gaggcggtaa cgagcgccgg ctcatcgatt tgaacccatt ttacgccttc 1332781 ttcttcaagc tctttcaaaa gctgtacata taatggcaca aggcgttttt ggatcgcttt 1332841 tgcttcagac ggttcatagc ctttagcaag cgtaacgaac gtataagggc cgacaatcac 1332901 aggctttgtt tccacaccgt attcctgttt gatccggcga taatcttcga gttgtttgtt 1332961 tcttgtcaga cggaactcaa tgctctcgtc atattccgga acgatgtaat ggtaatttgt 1333021 attaaaccat tttgtcattt cactagatac agcgtctttg attccgcggg cgatagcgaa 1333081 gtatgtatcg gtagcgtcag tcaaatgtct gaaccgtttc gggatccagt tgaagctgac 1333141 tgctgtgtcg agtacatggt catactgtgt gaaatcagaa acaggcacaa catcaatctg 1333201 ctggtcaatt tgtgttttta ctgcggataa aaatagttcg tcgatttgct tcaaaaacgt 1333261 atctttatca gtactgcctt tccaatacgc ttcaagtgct tttttccatt cccggttcag 1333321 tccgattctc ggaaatccta aattcgatgt tttgatggtt gtcattgttt ctcctccttt 1333381 atatgtaaaa cactctcttt cacccgcgga tacaggctgc taagaggttt tctcacaaca 1333441 aaaagcctct ttcccatgag agaaagaggc ttttctacgt aaaacactgc ctctctcatc 1333501 tctcagacac aatctgatgg aattagcacc gtgccttatg agacatcagt ctcggcgcga 1333561 aaagcagtgc gccccatttc acaatggtat tacggtcggt tgctgttggg gtcaaaaggc 1333621 caatccctcg cccaactctc gataagagaa aatgttatta attttttgaa aagttgaatc 1333681 atttgttggt aatcttaaca gtaattcaaa ttcattgtca acatagaatt tgaaattttt 1333741 atttacatga tgtggtgtat attatataag aaaaataatc ttatagggtc aacaaatgtg 1333801 attgctctgc tttttctgcg agctcatcag gagctgttaa atacaggaat ccattgcctg 1333861 ccagcgtttt tgcaatatca agaggaagtg tcctgcggat tagctgtgcg aaaacctcag 1333921 attcagaaag ctttctttga aatgattctt cttcatagct tttgattaaa gcaagcgcac 1333981 cgctgacatg aggggcagcc attgaagtgc cggtcagctt accgtacttc ttgttgggaa 1334041 gggtggataa gatgttttct cctggtgcca caaggtcaat ctctttattc gcgttagaaa 1334101 attctgataa ttctcgcgct acagaaacag atccaactgc aatcacttca ttataagctg 1334161 cggggtagga aagctcttct gtgcgttcgt cgccgtcacc ttcatttccc gctgcacaaa 1334221 cgacaagcac tccgtttttc actgcgtttt tcactgcttc ttttagctct ggcacatcgc 1334281 ttggccctcc aagggacatt gagatgatgt cgactttctg ttccaccgcg tagttgatgc 1334341 cgttaattat ccattcgtat tgtccgctgc cgttctcgcc gccaagaacc ttcacaatca 1334401 ataggcttgc ctcaggcgcg actccggcaa tgcctccgtt tgaatcatta gctgcaattg 1334461 ttccggcgac gtgtgtgccg tgtccgttgt agtcggaaat cgcatcttcc ttgccgccgt 1334521 cgtcatccgt gaagttcttt ccgccgatga tttgattttt taaatcaggg tggcttgtgt 1334581 cgcagcctgt gtctaataca gcaactttaa tatttttgcc ttttacccct tttgcccaca 1334641 tttctggcgc cttaatcact ttaatgccct caggaagctc gtttacatcc atgatctgct 1334701 cattcgtcac atacgggatc aagcggattt caccattcat aaaaaagccc tcctttttta 1334761 tgcttgcaag tggattcaag ggtgttgcct catattatat gaaaaaagca agcgctcgga 1334821 cagagccatt tgaagcattt tgaaaaaata ggatacacac caaagaatta gtaatcttca 1334881 aaatattgga tggcttcaac atgtatgact gggattcaac tgtaagtcaa gttataatag 1334941 tgttggggaa aggagcagtg tcatgaaact gaatgaaaaa ttatatgcat ttttttcaga 1335001 gcatgtggaa caaatggccg aggaatggat tgaaacgatg gaggaaagtg atccgaattc 1335061 gctttacgcc ctacataatg caacagtaac ggaagaattg aaagagcagg acagagaatt 1335121 ttaccggcat ctgaattaca tgtatgtttt accggaaaaa caatttctcg aagagtttca 1335181 agagtgggtc attgagctga ccaacgatca aaaacatctc gacacaccgg ttcagtatgt 1335241 cattcgggag tttatgagaa acaggagatt atatacgaag tattttgaga agttcgcaga 1335301 agaaaatgaa tcagcgtttg aaccgggaga gaagcaaaaa tgggcagatt tgattgtaaa 1335361 agtatttgat ttcaccattt atacattcgt tgatcacgct gaaatgaatg ccaagcagca 1335421 attaaacgcc caaagagaaa tgatattgga attaagctca cctgtcatta ccctgagcaa 1335481 atcaacagct ctgctgccgc ttgtcggtga cattgatacc gaacgggcga agtttattct 1335541 ggaaaacacg cttcaagctt gtgcgaaaag acgtgtggag catctgttaa tcgatctgtc 1335601 aggtgttgtt gtggtggata cgatggtggc gcaccagatc tttaaattga ttgaggcgct 1335661 taatctgatc ggtgtccggt caaccctgtc aggaatcagg cctgaaattg cgcaaactgc 1335721 tgtacagctg gggattgact tttcgaatat tactattaaa accaaccttg cccaagcatt 1335781 aaactatcat caataaaaaa atccgctatc tgtgatagcg gattttttat gatgcgaaac 1335841 ataaagatac gagaaaggat cccgcgaata ataagaggac gaggcaaaag aacacccagt 1335901 cgcgccggtt cacgctcaat gtcctgtagt atgtccggtt tctgcttcct gtaaatcctt 1335961 tcgattccat cgcaagcgct gtccgttccg cttttctgat ggcgcttgcc aatagcggta 1336021 tggtatatcg ttttaacgca ctgattttat taatgatgcc gctctccgcc gctcctcctc 1336081 tgattttatg agcctgctga atcagctgga cctcatcctt taacagcgga agaaagcgaa 1336141 agcctgcaat gacaccgtac gcgagctttg gtgagagcct gcactgctgg acaaggctca 1336201 gcataaatag aatcggatcg gttgtaaaaa caaacatcat cgataaggcg gaaaagcata 1336261 aaatacgaaa cccgagagag atgccgacag acacattatc gctgttaatg gagatagggc 1336321 ctgcttgaaa caaaaaatta tccggtgttg tcggcacttt tccaaaaact gcggctgtcc 1336381 acacgcatcc gaatgctaaa atcaaaaacg gaatcgtaaa caacaaccat tttttcaatg 1336441 ggattccggc cgccagtaaa acgcccgcaa cgatgatgat ataaaaacat gccggagtgt 1336501 aagggttgta aataaacgac agcatgacga cacaacaaaa aaccgccgcc gctttcacag 1336561 tcggattaat gagatgtaac ggttgcttca tcacgcacct cctcttgaaa tgccatccat 1336621 tcatatagaa ggggaagggt gagctttgct ttttgaacaa gccctgtttc ttgagaaaac 1336681 aactgcgctg gagatccgtc aaaggccagg cctgtatcgt gaagcacaag cacgctgtca 1336741 gcatacgaag agactagctc catatcgtgt gtaatcataa ggacagcagt tccctctgcc 1336801 ttgatacgtt gaatcatttc catgcattca gccgccgtgc gggcatcctg gccaaaggtt 1336861 ggttcgtcta ataataaaac ctttacgtca tgcatgagca tagtagctac gctcagtcgc 1336921 cgtttttgcc cttggctgat cgcaaacgga tgatgatcag ccaaatgcgc aagaccaaaa 1336981 cgctgcagca ggtgttgcgc ttttttctca gtttcagcat ttgctttctg gccgaacaga 1337041 agctcgtcat acaccgtatc ggtgacgaat tgatgctcag ggttttgaaa aacaaatccc 1337101 atccgtttac gcaattcttt ttctttatat ttctgcagcg gctgatcata gagaaggatt 1337161 ttgccgcttt gcggtttcat gagactggcc agaactgata ggagcgtcga ttttccagtt 1337221 ccgttcggac cgacaagcgc cgttaaagag ccttcgcgca acgaaaagct gatgtctttg 1337281 aaaatcgcct gctgtcctct cgcgaacgaa aggctgctga cttcaagcac actctcccca 1337341 gaaggggctt tcttcttttt gacatgcccg gcaggaatag gctctttgaa cagcatctct 1337401 tttgataaag taaacggcat actcagcttt tcctgcagat gacagacctt tggaatggcg 1337461 atgcccaatt tctttagtgt ctccgcttca tgctgaaata gatttttcgt caggccatcc 1337521 agtgcctttt tgcctgattt gtcgagtacg atcgttctct caatccaagg cgcccattca 1337581 tcaagctggt gctcaatgac gaggaggctg aaaccttttt cccgctgaag atccttcatc 1337641 agatgaacga actcccgagc tgagaaaggg tctaaaagag aggtcggctc atctaaaata 1337701 ataagctcag gctccatcgc caaaatacag gcgagagcca ctttctgctt ttgtcctcct 1337761 gaaagggttg agatcatttt ttcttttaaa tgggtaatgc gtaatttttc taatacggcg 1337821 ttgattttct ctgtcatttc ttcttttgga atttgcagat tttccagccc gaacgctatt 1337881 tcgtcctcca ccgtcagcat gcagaactgc tgatcaggat cctgaaaaac gaccccggca 1337941 tgctgagtaa tcgtttcgga ggtttcagca tctgtgaccg gcttttgaaa tagaaataca 1338001 tgtccggact gaatgccgtc gcaagcctcc ggatatagac cgtttaaaca aagggcgagc 1338061 gagcttttac cgcatccgct cggtcctaat aataaaacac attctccttt ttgaagctca 1338121 aacgaaatgt cttgaaaaac cggtttctcg tcttcttcat aagagaagct gagctgctca 1338181 accgtcagaa gctcatcaaa ggcttgcatg ttctgacgcc cgcttccgtt tctttttcag 1338241 ttcctttccg agtgccattc cgtttaacac acctgtataa gcgagagagt cgctgacagc 1338301 ttttccgaga agccccgcca aaagcgcgcc ggaaatgagg cggatcacaa gcataatgag 1338361 cagataacct ggtgaatagg ctgcatagcc agaaacaaag agatcataga taaagctggc 1338421 tactgaagac cccataccgg ccagcataag gacagggaga gagtatgctt tccagcgtgt 1338481 tgcaagaaat acagcctcag ccccgagccc ttgaacaatg ccaatgacga tgaccatcgg 1338541 gccagacgga tttcccagca ggcactcaac gagagcggca atgatttcag aaacgagcgc 1338601 cgcacccggt tttcgaatca tgtacgcggc gatcacagaa acgataaacc aaatgccgta 1338661 aattggttca taggcgattg gcccaaacat acctgcaagt acgtttccga aatgtgtaaa 1338721 taataaataa acaacggcaa atacgatact gataacggac atgatgacaa tttcttttac 1338781 tttccagctt ttcatgttat ccctgctttc tgttttttct tgatggactg ttagccgaaa 1338841 gattcacagt catggtgatg tggtttgttt gctgctcagc catgcggaaa acggcctcca 1338901 atgtgctgaa tacgtcatgc gcatccccgt caagctcgct cgcgtaatgg acaccctgta 1338961 cgaaagtgcc ttgggctttt gcaatgtcga cagcctccat aatcaatccc atataatccg 1339021 gctcattcat tggataaagg gcaaattggc acggcgcttc cgccttcaag cctcggacag 1339081 catcttcatt gacacgctta tcacctttgg aaagatatgt atccccctgt gtgtcacccg 1339141 ggcatccaat ggaaaacgtg ccgttcatga cgatgtgttg ttcgctgttt gctgcatgaa 1339201 ggtaaatggc ttttgcagca tcgaatacat gatcaatcga tccgcgtaac accgtgctga 1339261 tatggtcggt tttcgtccaa accttggatg tatctgtttt tttcagcgca gacttgatca 1339321 cactgataaa atcatccgtc atcggatata aagagaagcg aaaaccggcg attctgcttg 1339381 taccgcaaat atgctccatt tctccgacct cctgtttttt tggtaaaata aaaaactgca 1339441 tatcctaagg gaatatgcag tcatagatcg attaagcgca caaaaaaata caccattcgg 1339501 tcaacctgca cttccccacg ctggtattat ccagatcggg tcataaggga tcaaagcgcg 1339561 tttcttccgc gctttatctc agccaaaaca gcacccctag tgctttccgt atacaatttt 1339621 ttattttgac atcataatag atgataagaa tcattttgta aacaacgaaa tcattttttt 1339681 catataggga cgggagagga tggtcaaatt tggaaaaagg acacatatta attgtggaag 1339741 atgaagaaaa aatcgccagg gttcttcagc ttgaattgga atatgaagga tacagcgtca 1339801 cgatcaaaca caatggcaca gaaggtcttg atgcggcagc ggaaggcggg tattccttgg 1339861 tgcttcttga tgtcatgctt ccggggctta gcggactgga agtgctgcgc cgcttgagaa 1339921 aaacggattc gcagacaccg gtcatattat taacggcgcg agacagtatt cctgataagg 1339981 taacaggtct ggacatcggt gcaaatgact atgtcaccaa gccgtttgaa atcgaggaat 1340041 tgcttgcgag aatcagggcg gcgctgcggc aaaatggaac aaaaactgaa gatatcggca 1340101 cctttcttac atatgacgat ttgcgggtga acgaaaaaac ccgtgaagtg agacgcggag 1340161 acaaagaggt ggaattaacg ccgcgggaat ttgatctgct cgtctatatg ctaaagcatc 1340221 cgcagcaagt gctgacacgg gagcaaattc taagctcagt atggggattt gattatatcg 1340281 gtgatacaaa tgtcgtggac gtctacataa gatacatcag aaaaaaactg gactatcctt 1340341 acgaaaaaca gctgatccat acgattcgcg gggtcggcta tgccattaag gggtaaacga 1340401 tgaagctgaa gaccaagatt catctataca cttcgatatc actgttgatt ttattaattt 1340461 tggttcatac cgcagtatat ctcatttttt cgtctgcgct gacatcaaag gatgcggccc 1340521 ggcttgctga tgagacggat aacattgccg aagcgctgcg tgccgctgaa acagaaggag 1340581 tggctttgca ggatatgctg caggcctatc ttccggcaaa tggcatggtg cgtgtagtga 1340641 atggtgatca aaaagccgtt atgacgatca caaaagaaaa agcctataaa gattttcctc 1340701 tctcttttca tagcggcgaa acggcagatg tgaggaaacc tgacggcaag ctgtttgccg 1340761 aggctgctgt tccggtgatt tggaccgatg gacaagtcgt gtctcttcag ctggttgaaa 1340821 gactggagaa cacagaagag agtctgtttc tgctgaaaat catcttaatc gctgcaagtg 1340881 ctgctgtctg cattgcttct ttttttgcag gcagcttgct agcccgccga atcatcaatc 1340941 cgatcagacg attaatgatc acaatgaaag acatacagcg agacaaagaa tttaaaacga 1341001 tttctttaga aggacagtcc aacgatgaat tgtatcaaat ggggctgaca tttaatgaaa 1341061 tggcaatgat gctgaaggag cactatgata aacagcagca atttgttcaa gatgcttcac 1341121 acgaattgaa aaccccgctc actattatag aaagctacag cagcctgatg aagcggtggg 1341181 gtgcaaaaaa gccggaggtg cttgaggagt cgatagaagc cattcactca gaagcggtgc 1341241 atatgaaaaa actgaccaat cagcttttgg cgctggccaa aagccatcaa ggactcgagg 1341301 ttgatctgaa aacaatcgat ctgattaaag cggcgcgcgc ggttatgcaa acgctccagt 1341361 ccgtttatca gcgtgacata ttgcttgaaa cagataaaga gagcctgctt gtaaaggcag 1341421 atgaagaacg catcaagcag ctgttgacca ttttgcttga taatgcaata aagtatagtg 1341481 aaaagcctat tgagatgtca gccggaacga ggaatggacg gccatttcta tcagtgaggg 1341541 atgaaggcat cggaatacct gaggagcata tcccgcattt gttcgaacgg ttctaccggg 1341601 cagatgaggc acgaaacaga aaaacaggcg gaacaggttt aggcctttcc attgccaagc 1341661 aaatcgctga tgagcatggc attgagctgt ctgtcaaaag caagccggga caaggaacag 1341721 ctgtcaccat gcaattcagc gaacagaatg ggggaggccg atgactaaaa caataaaaac 1341781 agtatctttt gctgcagcag ccattttagt tgtcatcatc tgtacgtttc tcatcattcg 1341841 gcaaacccat gagaacgtat tgtcaaagga gactgtcgta aaaaaagtcg aagcctctta 1341901 tgaaggcaag gtcacgaaag caacacaatc aaaggataaa aaaacatatg atataaccct 1341961 tgaaaatcca aagggaactt actttgtaaa agcagacgca atatcggctg acattctttc 1342021 aatgaataga gtaaaagcag tgaatccatc tgccatgaca gaaaaagaag ccgagcatct 1342081 cgcgcttgag cgggtgccgg gaacggtcaa aaaacaaaca cggcaaagtc aagttgccac 1342141 ttataccata caaaaagaag acgggaaaac atacgaagtg aaggtagaca tgcaggcaaa 1342201 aacagtcttg tctgccgatc aaatcagcag caaagatcaa caaaaaacgc cgattacgaa 1342261 aaaagaagcc aaaacaattg cagagcgaaa aacgggcgga acagcggatg acgcagatct 1342321 cgaagaaagt gagggcactc tcatctttga agtagacgtt gatcttcctg ataataagga 1342381 agcgacagtg aaaatcaatg cctacacagg aaaggtagct aacattgtgt atgaagactg 1342441 acggtttctc atcaaattct catcttgctc tcgttttcct ttcatgttga gtatgtaaac 1342501 tgtactcata caaaacaaag gagggctcac aaatgctcaa gaaaaaatgg atggtcggtc 1342561 ttttagcagg gtgcctagcg gccggaggat tcagctacaa cgcgtttgcc acagaaaaca 1342621 atgaaaacag acaggcttct tctaagacgg atgcactcac tgaacaagaa gcagaagcaa 1342681 ttgctaaaac agttgttgac ggcacagtag aagacattga cagagacctt tacaacggca 1342741 aagaagtcta tgaagtggag attgaaaaag aaggtgaaga ctacgacgtt tatgtagata 1342801 ttcatacaaa acaagcgctt aatgacccgt taaaggagaa agcagaacaa gtcgccataa 1342861 ccaaagaaga agctgaagaa attgctttaa agcaaacagg tggaaccgta acagaaagta 1342921 agcttgacga agatgacggt gcttacatct atgaaatgga aatccaaacg aagcaaggaa 1342981 ctgagacaga atttgaaatt tccgcaaaag atggacgcat tatcaaacag gagatagatg 1343041 actaatcaaa acccccgctg cagcgggggt ttttcatgat aagaaacctt cttttggaca 1343101 atctaagtag aaaaggaggc gaaacgcatg gaaaagaaag aggagcaata catcaatcag 1343161 gctgaatatg tccctcatcc gacgaaggaa ggagagtatg ccttatttct tcatgaaacg 1343221 tatcatttgc tttctgaaga tgacgagaca caaacaacag aataagggct taggcccttg 1343281 ttttgttccg taattgtgat gtaagcgcat ttattacttt tttgagttga catagcttgt 1343341 ttttttctgt aatctcagtg tgtcaattca attaggaact tcgttaggtg aggctcctgt 1343401 atggagatac gctgctgccc aaaaatgtcc aaagacgcca atgggtcaac agaaatcatc 1343461 gacataaggt gatttttaat gcagctggat gcttgtccta tgccatacag tgctaaagct 1343521 ctacgattga aggcgcccgc acgctttttt tgccgtgctt ctttcacctt caatcccgaa 1343581 ggcttttttt atgcctttaa aacgaaacca atcaaaggag gtgcggagta tggattctcc 1343641 ccattcgagt caatctgaag aagtacccat atactatgac agcaagacaa ttgattacac 1343701 gatgaggaga cgaactgccg caccttctgg cgaggccggc acgtctccgt agaggaggta 1343761 cgagtcccga tggttcaaaa catgacctat gacgaactca ttttacgcat cattatttta 1343821 ctgcgagacg ggaaaatcag ggattttaga agtgttattg atgagcttca gccctatgac 1343881 atggcattta tttttaaaga aatgccggaa aaacatcgcg cccgctattt atcttattta 1343941 actgtagacg atatcactga tatgatcggg gagctggaac gcgaatttca gcttgtcgtc 1344001 ttaaataaag tcggaaaaac aaaagcaaca ctggcgatga acaaaatgga caacgatgac 1344061 ctcgctcaat tgcttgaaga aatggacgaa gaactgaagg aacagctttt atccagcatg 1344121 gaagcgtcag aatcaaaagc tgtacagctc ttgatgaatt acccggctga ttcagcggga 1344181 cgcatgatga caaaccggta tgtgtggatc cctcagcatt acacggtaaa agacgcggtc 1344241 gtcaaactga aaagcttcgc tgaaatagct gaatcgatca actacttata tgttattaat 1344301 gaaagcaaac agctggttgg ggttctttcc taccgcgatt tgattctggg tgaacctgaa 1344361 gaaaaggtgc aggatttaat gtttacccgc gtcatatcag cagatgctct tcaggaccag 1344421 gaagaagttg cccgcctgat agaacgttac gattttttgg caataccggt tgtagaagaa 1344481 aacaacgtgc ttgtcggcat tgtgacggtt gatgatatta tcgacgttgt tattcgggaa 1344541 gctgatgagg attacgaaaa atttgccgct tccggtaaag acatcacctt tgacacaaaa 1344601 gcttacgtgg cggcataccg gcgtctgcca tggctgattt tactcttatt tatcggactg 1344661 atttcaggaa gcattatcag ctattttgaa gacgcgctga agcaggttgt cgcgcttgcg 1344721 tttttcatgc cgatggtgtc agggatgaca ggaaatacgg gaacacaatc tcttgcggtt 1344781 gtcatcagag gtttgtctaa agaagaaatg aacaaaaaaa cgattgtgcg cctgatcttc 1344841 cgggagttca gaacaagcat ttttatcgga gcggtttgtt ctgtgctgat tgcgattgtt 1344901 tctatcatat ggcaggggaa tgcgcttttg ggatttgttg tcgcctcttc actgttctta 1344961 accttaatca tcggcacgat gtcaggaacg attatcccta ttattttgca caaactgaaa 1345021 gtagacccgg cgattgcttc tggaccgctg attacaacgt taaacgatat tttatcttta 1345081 ttaatctact ttggcattgc cactgcattc attcactcat tataaacgta aaaagtccgt 1345141 ctcaactgcg agccggactt ttattattta acggtttttg taccgaaagt gagcattaag 1345201 ctgcccctcc agcatttttt tccgcacttg cggatcgttt tttaacatct gttctttttt 1345261 gcgcatatcc tttaaaatct ctgccgtctg tacgccgtct tcacgcttat tggcgatatc 1345321 catcagccgc tccacatcgg caaaggagta ttttcttgtc ccccttgaag aacgctgcgg 1345381 gtaaatgagc tttcgttcct cataatacct gatctgtctt acggacaatc ctgtcaattc 1345441 actcacaatt ccgattgaaa tcactttttt gtctttataa gaatgatctt ctgtggtcat 1345501 ttttccaccc ctggatgtct tttgataata gtatataaaa aacaaagaga aaaaacctga 1345561 cgcttgtcat attttctaac atcaaataga agatttttga aaaaatacgg aagaaaaatt 1345621 aacaagaata atgcgtaaca cccaagcgcg ttttatcctt tatgtaacga atcaaacgag 1345681 gaggaaggat aatcatggag gaagaaaaag cagtctcact ggcaaaagaa attatagagt 1345741 tggatatcaa gcgtgatgaa atgctggaga cgtttatgca gcttgccgga gaacaggctt 1345801 ttcaattatt aagatcggtt caaaacggac aataccgaaa atcttcgtaa acataaattc 1345861 tttacattag attcatacca cgttcattta aaaagagtat cttttgtata ggatacctca 1345921 aaatgaagga ggacgctatg agtaatttat tgaaatccgc tttagaaaaa gaacgacgcc 1345981 attattctga aaaactctat cagatagggg tttataataa agaggtcatg aacaaaatga 1346041 cgatttctga gcttcggaaa gaatacgctt atttctttcg aagcattaca aatcataaaa 1346101 attatcctta tacaagataa tgtataagga tttttttgct tttagaagga atttctcgaa 1346161 ttatagcgaa tacgtatagt aagggactga actcttatta tatgtaaggg ttttcattat 1346221 ttttttataa aaatcctata tacgaggtag atatgatgag attatcgttt aacgaagaag 1346281 aagttgagcg tgcgatgaat ttgtacagag tttttgcaag ggctttcaaa agtgtgtccg 1346341 aacatagtat ccgtgatagc aaagagcacg gttttaatcc cactgaattt gctgtactgg 1346401 aactcctgta cacaagaggc ccgcaaaaat tacagcaaat tgggtcgaga cttctgcttg 1346461 taagcggaaa cgtcacatat gttattgaca aactagaaag aaacgggttt ttagtaaggg 1346521 agcaggaccc gaaagataaa cgctctgttt acgcacattt aactgacaag ggaaatgagt 1346581 atttggataa aatttatccg attcatgcac tgcgtattgc gagagcgttt tcaggtcttt 1346641 cgcctgatga acaggaccag ctgatcgtcc tgctcaagaa agcaggcata cacagccagc 1346701 atttgctgtt tcgttaacta ttctacactc tctatttcag gagagtgttt ttttgtttcc 1346761 atatgattct ttttaaaaca tctttaatct tcctatcaga catttcgcca aggtatccat 1346821 tgacgtgttt tttatactcc ttcatctgtt cgttcgattg aaaaaatgcc gcgatatact 1346881 cttctgcttt ctgcatgtcc cagtttctca tatctgtgac gagtttcctt tcatgtagaa 1346941 ggtttaaatt catttcctcc tgtcccggca gtgcatgata aataaatacc ggaagccgtt 1347001 tctgtaagca ttcactgatg gtcacgcctc cgggtttagt catgatgcct gtcgcctgtt 1347061 cgtacaaacg gttcatctct gctttgctgt gaaggtaagg aatcgcctca atcaaggggt 1347121 ggtgtaaact tttgacatag gagtagagct tttcgtttct gccgcataat attttgtata 1347181 agatctttcc gcctggcgac agttcctgca cccattttaa aatcccaccg acccccatac 1347241 tgccccctgt gatgatgatg gtatatggcg ggtggtgctg caaggtatct gctgattcca 1347301 tttcaaaatt ttggtgaact ggaatgccgg tcaagtatat gttgttctga tcgataccct 1347361 ctgatattag ctgcttcttt acttccgtgc tcggaacaaa atggtaatca atgttcttcc 1347421 gtccccataa ttgattcacg aaaaaatcag tgtatacatt cacaaccgtc agattcggat 1347481 attcaggctt tagtcggttc agcagataag aaggcagcgc atgtgtgcag aaggcgatat 1347541 caggctgttt ttcttggagg atgtgcctca tttgctgtgt gaacagccat tcgtacatga 1347601 aatagcgttt gtcatgctga aattctccgc aggcgaggag cctgtaaatg ccgctgtacg 1347661 ttttcgggaa atattgaatc cattttaaat aagccacgga ggacaatttt tctaaccgcc 1347721 tatacgaatg tgaaaagata tcaatctttt cagctgccag cccttgagac tctaattcag 1347781 cctgcaatgc atcagccaca tgatgatggc cggtggaaat gcttaaaaaa ggaaaaatga 1347841 gaatgttttt catgacagtc ctcctaaaaa aatatggcaa ctatattttg aggagaacgt 1347901 tcacaaaata taagggtgtt tttgatcata aggaaggtga aaagatgaaa acttgtttcc 1347961 tttccatatg gagagtggtt gatccgattt atttcttttt ttcaaggcta agcttgattg 1348021 acaacgatca aaaaagcgtt tttcgagtca ggctgacgaa gtacaaagga catcatgtcg 1348081 tgcttagcga cggaacgcat ataagaaaaa atgatgtgct cgttaaaatc cacctgcata 1348141 acataaagct gatcagggag ctgcaaagca ttgagagcgc agtcagaaag ggaatcatta 1348201 tttatcagaa agtatatcaa tcgatgccgc ttcttcttga ctatatcaac aatcataaaa 1348261 aaagcgagaa aatcaaagga atcattggga ttacaatgct tgacaaaggt gtggaaaggc 1348321 tcggctttga tgtgatcacc ccggtgaacc ctttttacag atgctttaaa aaagtgtctc 1348381 atgtgccgat tttatatttg acttcaaagc ctgtgagctt gcggcattta ccgaattcat 1348441 cctatttgtt tatctcaaaa gaaaagctgc agaaaaccta tcaaaaaaaa gactgatgcc 1348501 tcggtcagca cagtcttttt tgattaaatc tgatgaaatg tcacttcagg gcggcttccg 1348561 acacggatat ttacgccggt ttgtcccaag ccctcgctga tataaaatgg tttatcgtga 1348621 tgataatgaa ggcctttaat catgttcatt cgcacgagct ttcccatttt caccaaatga 1348681 tacggttttg gccagtgaat ttgcccgccg tgaaaatgcc ctgacagcag gtaatcataa 1348741 tgaacatctt tcatatccag aataatattt gggtcatgtg ttaagacaag atgatagcca 1348801 ttttccagac tttgataaga gccggtgata ttactccgat tcgtactgta atcatcaatg 1348861 ccgataatat tgactggtcc tgcagccgtc tcgattcgaa catgttcatt ttgcagcgtg 1348921 atacagccgt tttcctctaa aactcgcttc aatctctgaa agtcctcttc tttcaataca 1348981 taatcgtggt taccgaacac cgcgtacatt ccatatgcag gctttagctt ttgcaaggcg 1349041 ttcaagtaac ctgccagttt cggaatatta cgtttccgat caagaaaatc cccggtaaga 1349101 gcaatgatgt ccacaggctg atcttttgtt aaatgataca gctcctcagg tgagactgaa 1349161 atgttttcca agtgaagatc agataaatga aggatattta atttttttct ggctggaagg 1349221 ccgtcttttt ggtcgattga aatggtgttg actttcacat cttttgtatt gcggttcgct 1349281 ttatatagaa atggcacaaa tacgagtatg gccaatgaaa gtaagattgt aaacaaaata 1349341 tatcccctcc cttctatcag tatagtaagt gatcaagccc tatggatagc gggaattaat 1349401 gggtagagac aggttgaaaa acggattgtc atatgatgaa tgatttggaa gggaaaaggg 1349461 ataataaatt ttgacacatg aggcagaaca tgccgacgga gtcagaataa caaatggatg 1349521 tgtaagcaat gttacgattg atgagacaac aaaaaaaaga aacatattat ctctggatcg 1349581 cattatttct tcttttattg tatgtatccc cgctttttat tttaaaggaa gatgcccata 1349641 tccgggtcca cgataattta gattccaaca tcgcttggta caaggttctg gccgatagcg 1349701 gagaaatcgt cggcaaggtt gacgctgcca ttccgcaaat cattaacggg ctgccccggg 1349761 atgcctttgg caccgagtgg agcggaattg tttggctcca tgctttcttt tcttccatga 1349821 ccgcctatgc aataagccag acggttacaa gagttgtcgc tttttttgga atgtatgtgc 1349881 tgctgaagaa acatataatc ccggaaccaa aagcggcttt catccgaatt ggcgtatcgc 1349941 ttgcatttgc cttaacaccg ttctggcctt cgggaatgct gagtacgctt gggtaccctt 1350001 tggcactgtg ggctttttta aatatccgaa aaggggatat ctcatggaga gagtggctga 1350061 cgctgggctt gctccctcta tactcaagct ttgttctagg cttcttcttt ttcctggcag 1350121 ggatggcgtg tttttggctg tatgatgcca ttacaaaaag aagatggaat ttgatgttct 1350181 taggcagtat tgcatttatg acgagtatct atcttttcgt tgaatatcgg cttgtctatt 1350241 cgatgctgtt tgagcacgca ccgatgcatc gtatcgaatt tatctcatct aggcatgacg 1350301 tttggcattc tcttcgacta tccataaaaa actttgtcta tggccataat catgtgatga 1350361 ccgttcatac cgttgtcatc cttccgatcc tgatggtcgt atttgctgct ctgctgttca 1350421 aacgaaatcg gacaaagcca gaaaatgttt atctgttttt atgtgtgctt aattacgggt 1350481 tgtcattatg gtatgcgttt tggttcaaca aaatttgggc tgttccaaag cagaaatttg 1350541 cttttttagc agaatttaat tttgcccgtt ttcattttct tcggccgctt gttatatacg 1350601 tgagctttgc gcttgcttta tatctcattt ggcggatggg gaaaggatgg aaatggcttg 1350661 tgtacgccgc agtcgctgca cagctgatgg tgttggcgcc ttttaatgaa gaatatacgt 1350721 atggtgttca ttacaacgcg ccgacattca gggagtttta tgcatcagag caattcaaag 1350781 agattaagga atatatcgga cgtccgcaag attcgtatag ggtggcgagc atcggactgc 1350841 atccgtctat cgcccaatat aacgggtttt atacgttaga tacgtataac aatctgtatc 1350901 cgctctcata taaatatgaa tttagaaaaa tcatcgaaaa agagctggaa aaaaattctc 1350961 ggctgaaaca atactttgat gaatggggca gccgctgcta cctttttgtc gatgaactcg 1351021 gtaaacgata tgatttcaaa aagaactcga agaaaacgat caacaacctt caattaaata 1351081 cagatgtatt taaaaaaatg ggtggacggt acattttttc ttcagttccg atcatgaatg 1351141 ctgaacaaaa ccatctcgcg ctcgtaaaga cgtttgacca taaagattcc gcctggcgca 1351201 tttatttata tgaaacaaga taaggaggat atcgattgaa acagtcacag ccagtattaa 1351261 ccatcgtcgt cccgtgtttc aatgaagagg aagtgtttca agaaacaagc catcagctga 1351321 cagaggttgt agatgattta attgaagaaa aattaattgc tgaagacagt aaaattctgt 1351381 ttgtcgatga tggcagcaaa gaccgcactt gggctttgat tgctatggag agcataagaa 1351441 acaagaaggt taccggctta aaattagcct gcaatgtcgg ccaccaaaaa gcgcttttag 1351501 ccggattgca taaagcgaag aataggtcag actgcgtcat ttcgatcgat gctgatcttc 1351561 aggacgacat ctctgtgatc cgggatttta tgctgaaata tcatgagggc tgcgagatcg 1351621 tttacggtgt acgccggagc agaaaaaccg ataccttttt caagcgcacg accgcgttag 1351681 ggttttatcg tctcatgaat aaacttggga ttaaattaat ttataatcat gctgattttc 1351741 gtttaatgaa taaaaggtcc cttgaagagc ttgagcgtta tccggaagcg aatctgtttt 1351801 taagaggtat tgtccccatg atcggcttta aatcggccga agttttgtat gaccgcaagg 1351861 aacgctttgc cggcaaaacg aaatatccgc tgaaaaagat gctatccttc gcttttaacg 1351921 ggattacttc attcagtgtc gcaccaattc gattctttac gcttttaggg tttgttttgt 1351981 ttttcctcag cgctgtggca gggattggcg cgtttattca aaagctgctc ggccatacga 1352041 atgcaggctg ggcgtctctt atcatatcca tttggttttt gggcgggctg caattgatgg 1352101 gaattggaat catcggagag tatattggaa cgattttttc tgaagtgaaa agacggccga 1352161 aatacgcgat tgatattgat ttgtataatg aacagctgag cccgcttcag cgccaggaaa 1352221 aagagcggtt agaaaaaaag tacagttaaa cacggaaaga gctgacttca ttagtcagct 1352281 ctttttcttc aactgatgca atatagcgct aagcggttcg tcttgcgggt tgcggtaaaa 1352341 atcaaaaaat gggcagccct gcttcttaat tcgatcgatg accgtatcaa ttgtaaacag 1352401 agcgggtgtt aaagatgatt gcacctcatg ccagtagagc ggggctgcaa cagtcccaag 1352461 ctcatttcct ctcgttgaat agggacagat aatcgttttt ccttctgcat gctgcaaata 1352521 atcaagatac aatttgcagt gtctgttttt aatcaagcgt tcagtggtaa agagctcggg 1352581 aaatgcattg gtgcagtact ctgcgatcag ctgcgtaaat tggcgtgttt cttcatacgt 1352641 aaatgcctcg ggagacaagg gaatataaag ctggatgcct ttgttgccgg acagcttcgg 1352701 gtacgatgtg atgccaaagg aatccaacag ccgcttcagt tcatttgcgg cctgcacggc 1352761 cataagaaag tcatctcgcg aaggcgggtc taaatcaatg acaatctcag ccggacgcct 1352821 gcttttaatg gtttgaaaag gaacgtgaaa ctccaaagca agctggttgc aaagccatag 1352881 caatgtagac atatcctcac agacaatatg ttcatggctt ccatcataga aagactgaac 1352941 aaaatccggc gcatagtccg gcttgttttt ttggaaaaat gattcgctcc tagatccatg 1353001 cggatagcgg atgacggtga cagcccggtt tttcagaaat gggagcaggt agtcactgac 1353061 ttcaatcata tactgaataa aatcttcttt tgttttttta ttcttttcaa atatgatttt 1353121 atccaggctt gtgaactgga gctttgggtg aaccggtttg gagtgtcgta tgacttgcgc 1353181 atacgtgcat tcggtccagt ccatttggaa ttcgaaaccg ataaacgata cctctcttaa 1353241 tgtgccttgg agaattgtta agtattgaac agctgcacaa atcgaaggtt caagcgtaaa 1353301 ttcgcctgag ggtgtttgat gtccgtgctg ttccataatc tcgcgtatag cgcttttttc 1353361 ctcatcacgc attccgtgcg agacagaggc aatcggtgtc attattccgt tttttaacac 1353421 cgataccgtc agaaacccgt tgttagggtt gaaccctgtt atgcaaacat aagcttgttt 1353481 aaagttttta tatttgagcc aatcggacga ccgcttcttt tcaagccatt tgctgtttgt 1353541 tttcttcgct acaattcctt ctccgtcata ttttattacc atctcccaga gttgatcaaa 1353601 atgatcataa cagggaatgg attgaatggt ttcttttgcg taaggatctg gagatgcagg 1353661 aagctttgct gcggatatga gttcacgcag cgattttttg cggtccaaat acgaaagaag 1353721 cgttacatct tctccgcttc gctctaacaa atcaaaggcg agaaagcagc acggccgcgc 1353781 gtttgccgat tcctgaatct tgtctggcct tttcaaacgc ccccgcactt gaaggtgttc 1353841 aaaatctgca cgacagggat tcaccaaaca tacgatttca ccgtcaagtg tcagcggaag 1353901 ctctttttct aggtgctgaa aggcagtttt ggcgaattgt gtgatttcag ggaaggtgct 1353961 gctgagctcc acaccatttc tgctggttaa ggtcacacct gaagaatgga tgcggagaat 1354021 acagcggtac ccatcatatt ttacttcgta acgccattct gctccgattg gcggtgacga 1354081 agttaagacc ggctgcatgg taaacgccat gcgctatgat gtgccggagg ctttttttct 1354141 agttgttttt tgttttttat ctccggctcc tttcggttca gcggcttgtg caggtgcggc 1354201 agccggtgtc tcccggttcg gccttctggt tctgtcgatg ctggcttgca gagcgcttac 1354261 caggtcaatg acatcttcac gaggtggcgc tttatcagga gtgacagccg tttctttatt 1354321 ttctagcttg tcgttgactc tttgcagcag cgcctgtcgg tacgtgtctt catatttctc 1354381 aggctcaaac ttagcagtca gttcatctat taatgtgata gcagtttgca gttccttatc 1354441 gtttacattc gattgatcag gtacacctgg gacttgagcg gcgcttctga cctcatcggg 1354501 ataatggata gactccatga cgatacaatt ttcataaacg cggagaatcg ccagctgctg 1354561 ctttgacctg attgtcatat tggcgatacc gatctttccg gttgagcgca gcgcctcacg 1354621 cagcagggta taggccttcg tcccattatc cccggggccg acaaagtagg agcggttaaa 1354681 ataaatcgga tcaatttcct gaagctgaac aaagtcaaca atctcaactg ctttctcctc 1354741 atgctcctgt tttaagcttt ttaaatcttc gtctgtcagc actacatatt ttccttttac 1354801 atattcatat cccttcacaa tttcatcagg actaagagtt ttttcgcaat ttgtgcaaac 1354861 tttctcgtat ttgattggtg cgtgatcctc tttatggagg ctgcgcagtt taatatcttt 1354921 atcttctgtg gccgcatata gcttgatggg gatgtttact aatccgaagc tgatcgatcc 1354981 cttccacatt gtatgcatat cgataaaccc ctttttttct ttagtgtgaa gagaaggagt 1355041 acgattcatg tgtagtaact tatgggtgaa aaaaagccgg cgctgttatt gcgacggctg 1355101 ttcaataatg aattgttcga attgttccgg aggtattggc ctgctgaaaa agaagccctg 1355161 caaatggtcg cagccttttt caaaaagaag ctgcttttga gctgcatttt ccacaccttc 1355221 ggcaatcacc tgcaaagaca gctgatgccc catggcaata atagctccgg taatttgctc 1355281 tgatttagga tgggtctgaa tatcgtcaat aaatgatttg tcaatcttca gcctgtgaat 1355341 cgggaagtcc ttcaaatagc taagagagct gtgaccagta ccgaaatcgt caatactgat 1355401 tctgattcct aattctgtta gggatgacaa aacctttttg gagtgattga gattgtccat 1355461 tgtcatgctt tccgtcacct ccacttcaag aagctgcgga ggaagctggt acttattaag 1355521 cgtatccttg atgaggggaa tcagatcttt agattgaaac tgtctggcgg aaatattaat 1355581 ggcgacagaa agatcatagc ctttgtcatg ccaaatcctt gcctgcttgc atgcttcatc 1355641 tataatccac tttccgatat caataataag tcccgtttct tctgcaacac cgatgaattc 1355701 tccgggcgga cgcagttgcc cgtctggtgt cacaaggcgt atcagtgctt ctgctcctgt 1355761 cattttttgt tttttcacac tgaattgcgg ctgataatgc aagacaaatc tatcgttttc 1355821 gattgcttct ctgagtacca tctcttggtt aagcttaacg gtttctttgt tgccgattga 1355881 aaaagaatag tatctgtatt tgcttttgtt tcgttcttta gccgcataca tcgccatatc 1355941 agcctttttc atcaattcaa ggccatccgt cccgtctttt ggagatatcg caatcccgat 1356001 actgacagat gtgacaaggg tgtgatcttg aattttgaaa ggttttttga atttttggat 1356061 aatttttctt gctaaaacat ctgcttcgcc tgttcctgta ttggcgtctg ttaatataat 1356121 aataaattca tcaccgccaa gacgggcgat aaatccgtta tcagggacta cagatgacag 1356181 gcgtttagct gcaaactgaa gcaattgatc accgacatta tgccctaatg catcgttaat 1356241 cactttaaac cggtttaagt caagaaagaa tacaacagtg ttataatgca aggaatgctc 1356301 gcgattcagc acctttgtta gatgagagat ggcatgcctt ctgttaggta agtctgtaag 1356361 cgaatcataa tgagccattc tatggatttc tttttctgct ttgtactgct tcgtcatgtc 1356421 tttacaaatg acataaatgc tgtctagttc ctgattgacc tcaacaggta taagcgtaat 1356481 atttaagtga aactggcctt tttcagtgat aagatcgcta tcgctgttca tcgcttgttt 1356541 atctttttta acttgctcaa aaaggcgctt aaccttcagt gatgtgtaat tcctccagtc 1356601 atgcatgctg aagccaaatt tgctgatcat ttcctcacca gcgtgattgg aagatattat 1356661 gtctccttct aatgataaaa taaaaattgc atcaatattg tggacgatta aagactgaaa 1356721 tcgctgttcg ttatccttta tgcgttcgct ctgtttaata aactttcgat ctgcatggga 1356781 actgaataac aataacgttt ggatacaaaa aataattaaa gtaacaaaaa ttgaccaatg 1356841 aaacgtttgc acctccatat ggcttccggg cggagccatg tccttatgga aagttgccgc 1356901 aagcatccct gtgtagtgca tgcccgaaat cccaatgccc attacaattg aactgacgcc 1356961 tttatagaat ataagatgct cagaatgttt ttttacggcc aagtcaaaga atatttttaa 1357021 cgagacgaaa gaggctgcaa tcgcaatgat aattgaaact gtaaataaaa taggttcgta 1357081 aataatcatt acccgggaaa tggcagacat tccgatatag tgcatagaag caatagatgc 1357141 gccaagcaca actgatccgg taagcagtct gtaatatgta agaatgtgcc ggctgacaaa 1357201 atataatgac acaaatgatc ccgaaacaga tgcgccaatg gctgccatta aaggcatgaa 1357261 ttcatattcc atcggcattt ccatatggac ggccatcatc cctacaaaat gcattgacca 1357321 aataccgaat cccataataa gtgagccgcc gatcagccaa attttacttt ttaagcctgt 1357381 attgatggtg actttccttg aaagttcaag ggaaatatac gaggcggtac aggcaattag 1357441 aatagataaa catatgagag tcgtattata tgtaacgtgt atttccaaat ggagattccc 1357501 cccgtatcgt gtgttccagt cttgttgact ctctttatta tcggctgctt aaccgcagag 1357561 tttcagcctt caaaacgata gaaatacgag ggagatctat ttttagttca actgaccgtg 1357621 aaaaatgtgt taaaatcatc ttgatgtttt ccgaaaagag aaaaatgtat gatacataaa 1357681 catgaaacaa gggagttggt ggctatcgaa gagctggtta tgtcatggat tgaagcattt 1357741 aaaagcttat cttattttgg aatatttcta gcgctcagca ttgagtttat tccggccgaa 1357801 gtcgtcttgc cgcttgcggg ctattgggta tctaaaggcg atatgacact tgctggcgtt 1357861 gttttggcag gatcgcttgg aggagtggcc ggtccgctta cgctgtattg gataggccgg 1357921 tacggaggaa ggccgtttct tgaacgtttt gggaagtatc tctttattaa acctgaagcg 1357981 cttgataagt cagataattt tttcaaaaaa catgggggct ttgtcgcctt cagcggccgt 1358041 ttcttgcctg gtatcaggac attgatttcc ataccgtgcg gaattgcaaa aatgaatgtt 1358101 tgggtgtttt cgctttatac attcattgct atgcttccga ttacatttgt atatgtttat 1358161 ctcggtgtga agctcggtga aaattggaag gcagtcggct ctattcttga tcaatatatg 1358221 cttccgatcg ggatagcgat tttggcgctg ttcctgctct acttactgat gaaaaagagg 1358281 aagaaacgca cgcactccga acaattatct gtatttttga aaaataaacg ttgacaaatc 1358341 actgcgctgc gcatattatt gacgtataaa atcatatttc ttgaaatccc aaaggggagt 1358401 agcgtccgga atgtattccg gaaacaaagt cgtcatttca tggattgtat ccatcggctt 1358461 tgttggcatg cctgaattca tgtctagcaa gacctttgcc ttatgtcggc aaaggtcttt 1358521 tttgcatggt ccggccggca taagatcgga tgaagagaaa gaaaacaact tttttgggag 1358581 ggtatcattt atggatgcag cattattatt agagtatggt tgggttcttc tcgtcttgat 1358641 cgggctggaa gggattttag ccgccgataa cgcgctggtt atggcggtaa tggtaaaaca 1358701 tttgccggag gaaaaaagaa aaaaagcgtt attttatgga ttggcagggg cttttgttct 1358761 gcgatttggc tctttatttg caatttcttt cttggtcaac gtatggcagg ttcaagcgat 1358821 tggcgcgatc tatttgctgt atatctcagc aagccactta ttgaaaagat atgtatttaa 1358881 gaaagaagac acacataaag agacgaagca aagcggtttt tggccgactg ttttaaaagt 1358941 tgaactggca gatatcgcgt ttgctgttga ttccatctta gcagcagtag cgctggcggt 1359001 tacacttcct gggacatcac tcccgaagat cggcggactt gacggaggac aatttctcgt 1359061 cattttggcc ggcggtatca tcggactggt gatcatgcgg tttgcggctt ccatgtttgt 1359121 gaagttatta aaggaacgtc caagcctaga aacagcagcc tttgtgattg tcggctgggt 1359181 cggagtgaag cttgctttat atacgcttgc ccatcgcgac atagcggttg tttctgagca 1359241 ctttatccat tctggaacat ggaagctgat attctggggt gtcttagcag caatcgcggt 1359301 ttgcggctgg tttatgtcag gtgggaaaaa acagccggag ggtgcacaaa acgaacaaaa 1359361 aaacagcacc cgtgaacggg cgtaatctga aagactctgc ttaaaagcag agtctttttg 1359421 tgtttgaagc gttttcataa gcgaaataaa ataacatttt tataacatct ttgttacaaa 1359481 aaacacgcat aaaaccccct taattcttta gaaaggcacg aaatcatgta tagaacgtca 1359541 gaatggtttg tcataattga gacattggaa atcaatattt ctttttctcc tttgcgaatc 1359601 cctatcaaat tagctatcat taatgagtag ttatagggag gaactgaggt gaaaccagtg 1359661 cttagccttt tgtttaaatt gggaaaaaag aagcaaacac ttgaaaaagc tgttgagagt 1359721 atacaaaaag gcaataaaga tctgcaaaat gaattaatac agcaatataa gccatttatc 1359781 gcaaagacgg tttcatccgt ttgtaaacga tatatagatg aaaaagacga tgagttcagt 1359841 attggactga tcgcgtttaa tgaagctata gaaaaatatt cacctgaaaa aggaaattct 1359901 ctgctcgcat ttgctgagct tattataaaa agaaaagtca ttgattacat tagaaaagaa 1359961 gccagaagcg cacaaaatat aaatatcgat ttacaggaag gagacgatca ggagtcatca 1360021 caaagcctga ttgaagccga gctttccatt gatgaatacc gccgtcagat tgaacaggag 1360081 cagaggcggg aggaaatcct ctattttcaa aagcagctca aggattatgg tttatcgttt 1360141 aaagaactgc ttgaaaattc tccaaaacac acggatgcaa ggcaaaacgc cataaaggtg 1360201 gcaatgacgc ttgttgaaca tgaagaattg gccgctatcc tgtatacaaa gaagcagctt 1360261 ccggtcaaac agcttgaaca gcttgtctct gtaagccgaa aaacgattga gagaaacaga 1360321 aaatatatta ttgcgatgtg tattatcatt acgggtgatt atatttattt aaaagattat 1360381 cttaaagggg tgctgcactc atgagaagag ggattatagt agagaaaaat aaaaaattcg 1360441 tcacgttgct gacccctgac ggacaatttt taaaagccaa aaatgatcga cacagctatg 1360501 aaatcggaga agaaatcatg cttccgagtg aaacacgcat gggcagaagg gccagctttt 1360561 ttgatttttt taaactgcgc cctttcaaaa tggggatttt tacgatgact gctattatgc 1360621 tctttatttt tatagttctc cccgtttttt ctaataataa ggcctatgcg tatatgacaa 1360681 tcgatatcaa tccaagcgtc gaaatggcgt taaacagcga ttatgaagtg attgaactga 1360741 cgcctctaaa cgatgaggga cagaaagtcg tgaatgatat agatgattgg gagaagactg 1360801 attttaaaaa ggtgattgac gatattataa ccgactgcag tgaacacggg tatgtaaaaa 1360861 aatcgaaaga aatattgatt tccactgttt atgaaaacac agaagacaat acatataaaa 1360921 aggctgtgaa aaaacagctg aatgatgtga ctgaaaaata taaaacgaca taccgcatgg 1360981 aatctctcga gtcagatatg caaacgaggg aaaaagcgaa gaaagaaggc gtctcaacag 1361041 gcagctacat caaatcaaat gaaaagaatg acaataaaga tataaaagat gactccagca 1361101 aaccatccgg ggaagaggat caaaagagtg atgaaaatga ggatgaaaac accgatcaaa 1361161 ctgacaccca ggacagcaag caaggagata atgaacagct gaatgatgcg gattccggag 1361221 accagaaaga agagaaagcg gatgaccaga ttgatgatag tgacaaagat aaaaaaataa 1361281 aggaatcaga tgaaaacaca aataccgaaa aagatgggga ccatgagcaa accccaatac 1361341 aagatcctca agataaagga aatgaaaata acggcgctga caagggccaa agccaatatc 1361401 acagggactg gaacaatggt gaacaaggca agaaccgttc ttcgtccaga agggataacg 1361461 cttcagaccg acgtaatcca aacggctaca gcagtgataa tcattcagct aaaaatgaag 1361521 attcgccgag tgcccccggc gaataaagac ctgaatttat ttagttgtgc catttaattg 1361581 tgattgtgct tgctgtacca gccgctttgt catttctccg cctacagagc cgttagcgcg 1361641 tgcgactgta tcagaaccaa ggttcacacc gaattcttga gccacttcga gtttaaattg 1361701 gtctagtgcc tgctccaccc ctggaacaac gagtttattt ctgctcgcca tctttttcat 1361761 ctcctttttc gataaagaaa ttcttaacgc gtatttagtt tgaaatatac ggggtttatt 1361821 tatgctggca attgttgtgg agaaaaataa aaccccggcc tctgagccgg ggtggcgcag 1361881 actatagaat gtctgctgtc attttatgtg cggttgcctg aatatggaat gtcaaaatgg 1361941 agaggactgt aatggcgata atctgtctga ttttaagcca ttggctgtca ttcagttctt 1362001 caaaacggtg acggagacgc tctgtctcct gttcggcgat ctcctgcaga tttgattctt 1362061 tcatagaagg agtatcttgg tgatggatgg catcaagcac atatgcgcag ctttcataat 1362121 aagcaatcgg gctgatgaca tcatcagatc tgtctgagat tgtgttaaag gccactttta 1362181 aaatagcccg tatgtgttca aagtcataaa tggattttaa atcacgtaca attaaaagaa 1362241 taactgcctg ttcaattgag tattttttgc ccagctcagg gtgtccgatc agatctttga 1362301 tatcacgctt tacccagttt tgaatcgcgg ttgactttaa cgaagtcagc tcgcataagt 1362361 tgccaagctc tacgatttca tttgtagaca gaccgtattc ttttttctgt ttttttcgtt 1362421 cgtatcttgt aagaaattca ggaatttcta gatgattggc tgctttttct gctgacatgt 1362481 tcgctgattg gacgagaatg tcgagcgggc tatgttctcc ttgtcctttt agggaataga 1362541 gcagccgcac catatcggtt cgagagagtt taaaaatgtt cattgttcac ctctttaaac 1362601 aatttgacgc ggatataggt ctatgtataa gttcaaaatt caagcgtcag caaattacat 1362661 taacatcata cgtcgaattc cttgcatttt caaatggatg ttttataatt taaatatacg 1362721 ggttcttttg aacttaaaat aacggaggtt gttatggcga aaagaatttt tctgtttatt 1362781 ctaacgaata ttttggtgct tacaacaatc gggatcgttt tgtctgtttt aagctctgtt 1362841 acaggagtcg ggacgtactt tacagctgat ggcggtatcg atccaatggc gcttcttgtg 1362901 ttcagtttag tcgttggatt tgtcggttcc tttacgtctc ttgcgatatc cagatggatg 1362961 gcaaagacga tgatgggcgt cagagtgctg aatccgaaaa aacactcgct cagctatgag 1363021 gaacagcaat tggttgatcg tgttcacaga ttaagccgct ctgccggttt aacgaaaatg 1363081 ccggaagtcg ggatttaccg ttcacctgaa gtaaacgcgt ttgcgactgg accgtcaaaa 1363141 cgccgttcac ttgtcgcagt atcgtcaggg ctgctggagc agatggatga cgcagcagtt 1363201 gaaggtgtgc ttgcccacga ggtcgcgcat atcacaaatg gtgatatggt aacaatgacg 1363261 cttttacaag gtatcgttaa tacctttgtc gtctttttat cgcgtatcgc cgcttggata 1363321 gcaagccgtt ttgtcaaaga agatctagcg ccgatcgttc attttattgc aatgattatt 1363381 tttcagattg tcttttcgat acttggcagc ctggttgtgt ttgcgtattc acgccatcgt 1363441 gaattccatg ctgacagggg aggagcggat cttgccggca aggacaagat gattcatgcg 1363501 ctgcggacgc ttaaaagcta ttcttcccgg attttggaag acgatcagac agctgtccaa 1363561 acgttaaaga ttaatggcaa gaagcgctct tcacttttct ctactcatcc tgatttagat 1363621 gagcgaatca gacggctgga agctaaataa tacaaacaca ttgttcctct gagagaattc 1363681 tcagaggttt tttattttat ccattgacta aaatcataaa aaaataagca agttaagaaa 1363741 atgtttcgta aaagccttta aaaatggacc taatatcttt agaataatta ccgtacttaa 1363801 aaagagaggc agaaggattt tacatgagat taaagtttgg aaaattgata caggccttgt 1363861 caccggccca gctgatcgca ttatattatt ttcttgcagt tactgtggcc gttatattgc 1363921 tgagtttgcc ggcggcccat aaaccggggg cggattggac gtttattgat gcgcttttta 1363981 cagctgtcag ttcagtcagt gtaacggggc tgacagttgt tgatacagct gatacattca 1364041 gcacaatagg gatttttata ttagcatttg ttctgcaatt tggcggaatc ggaattatga 1364101 cgctcggaac gttcatttgg ctgatcatgg gaaaacgaat cgggctgaaa gaacggaagc 1364161 tgattatggt tgatcaaaac caatcccagt tttcaggaat tgtcaatctg atgaagcagg 1364221 tactgtttct gatcttgtgg attgaatttt ttggcgggct gatactcggc acatatttct 1364281 taacctacta tgactcctat caggaagcct atttacacgg attttttgcc agtatcagtg 1364341 caacgacaaa cggcggattt gatattaccg gtaattcgat gattccattt cgccacgatt 1364401 actttgtgca gtttattaca atgcttttaa ttatatttgg agcgattgga tttcccgtgc 1364461 ttgttgaagt aaaggatttc ctgttttcaa agcatcggcg ttatccattt acgcttttta 1364521 caaagatcac gacgattacg ttcggctcac ttgtcttgtt tggagccatt ggcatctttg 1364581 ccctggaagc aaaccatgcg ttcgcaggaa aatcatggca tgatattttg tttttgtccc 1364641 tgtttcaatc aacggcaacc cgaagcgggg ggctggcaac aatcgatatc agccaattat 1364701 cagattccac actctttttt atttgtgcgc tgatgtttat tggagcgtcg ccaagctcag 1364761 tcgggggagg cataaggaca acgacttttg ctttgaacct tcttgcgctg tttcattttg 1364821 cccgcggcaa taaggccgta aaggtattca aacgggagct tcaccctgct gacttgatga 1364881 agtcgcttgt tgtcacgatg atggcgatcc tgctcgtttt tggcgcgaca ctcattctga 1364941 ccattacaga aaaacattcc ctgctggagc ttttgtttga agtgtgctcg gcattcggta 1365001 caaccggcct atcgcttgga attacggcag atttgagcag tgttggaaaa tgcgtcatta 1365061 tgattgtcat gtttatcggg cgaatcggca tcttgacctt cctgtatctg atcggaagaa 1365121 aggaaattga agcgaattat cactatccga aggaaagagt gattatcgga taggcaaaac 1365181 accgcatatt ttgcggtgtt ttttgattac caaaaaaaag atgtgtgcct cctgttcagt 1365241 tggagaacct aactccgaca ggtgcaattt acgctcctgc atcttaaaat gtctgaaaat 1365301 tggcgaggag gattcgtatg aagcgtaaag ctgaagtgaa tgaagccatt aaaaataaca 1365361 atacacctac cgagagcatg gaccccaatt catataagac acaatatcat gacgacccca 1365421 attttagagg ggcaaaccgc aattccaaac agggccagca gggaggcatg taattgtgaa 1365481 gaaaaaccgt catagcagag acatgcaaaa tcataaaaag cctatgaata aaaaggtgct 1365541 ggaggaagaa ttctcaagtg aactcgggga ttacaatgcc ggaaagatca tcgaaacgct 1365601 ggaagtcacc aagcctgaaa agaaaaaaga aaaaaacaaa aaacaacaat aaaaaagacc 1365661 tcttaggcgg cgtcccgctt aagaggtgct ttttctattt taaataagca tttttgcccg 1365721 ttcctctgac aaattgcaat aagcttgtca tcctcagctc aatgaatggc tgagcgactg 1365781 tcttaacaaa gttgctggag aggactgatg tcagggctgc tgttaaaagc aagaggatca 1365841 ctaagctttg atagtcagta agccaatcct caagcccgac ctgccgtaat gtcttaataa 1365901 taaacccgtg aagcagatac acgtaaaatg tccgggttcc ccatttggta aagaaatacc 1365961 gtttttgcgg aacgagcgct aaaaagctga aggttgcccc aaaggcgagt acataccagc 1366021 cgattcggga tagtccgctt accagggtaa cgtctccaaa tgaagaatac ggttttgaac 1366081 caaacagaaa agaatagtca aaatcgatgc cccagcagat gacgaatact gcggcaagca 1366141 ctccgagcgc aatttgtttg ccgcgttttg atctcaataa atcaaaatga tgtttattta 1366201 aataaaaacc gacaaggaac atcggtaaga atacgaatgt ccgtgacaag ctcagcgtgc 1366261 tgctgacaaa gtccagataa ccgatcagca cggcgattcc gcagctgaca aacagcgccc 1366321 actgctttga aagctttgaa aaaggatata ggagcaggtt ccaaaagaat aagcttacaa 1366381 gaaaccataa cgaccattgc ggatcaatcg ggttcacatt tgccatgctt tcatcttgca 1366441 taatgtaata aaagacggaa taaataattt ggaaaatcaa atacggaata atcagcttga 1366501 ccgccagctt ttttacatat cccgcccgtt taaagccttt cgcgaaataa ccggatacaa 1366561 gaataaatgc aggcatatgg aatgtgtaaa tgaacttgta gaggtagagc ataaaatgat 1366621 tatcattaat aaaggaacga aggatatgac cgaatacaac aaggaatatc aataaaaatt 1366681 ttgcgttatc gaaataactg tcccgcgatt tactcatagc atcaccttct ctttcatcag 1366741 tcactaagag attattccct gctggtacat attttaaaat aaaagatgaa aaaggaatct 1366801 aaaaaaatgc tgattgttag gtcgatgtaa agtgacggta aggatcgtag aaaatgtctt 1366861 cgtaatgtaa tgacgctgaa attttctgaa atttataggg caaatgaagg aagttcccgc 1366921 attttgtaga aatattgagg gataggtttt gaagaaggag tgtacatgca tggaaactct 1366981 tggtgtccag acaaactcgg agctgcgaga ggaactgaat cgcctcaaag aagaaaacgc 1367041 gcgactgaaa aaggaattga atcagcatca agtgattgtc aacaatacgc tcgatgctat 1367101 ttttatttgt gataacgaaa tgcggattgt tcaggcaaat gaagcaacag aaaggatgct 1367161 tcaagttgac tcggaagatt tgaaaaagcg ttctgttttg gattttttgt tttcaatccc 1367221 aaaggatgaa ctgaatcttt ccgtaaagaa gttttttaaa aaaggctttc tgtggaagga 1367281 ggttccgatc aggcttgatt gcggggcaac aaaatacata gagtttctgg ccaaaagagg 1367341 tattggtgag gatttctttt ttgttgtcat gagggacata tcttctaaga agattctgga 1367401 gcgggaattc tctatgaatg aacagctttt taaggacttg tttgacagag cagttgacgg 1367461 aatcgtcctg tttgataaag atggcggttt tattgatgca aatttgtcct tttgtaaaag 1367521 ctttgaaatc aatcataatg agctgtctca tttatctttg tatgagttca tagacagcgg 1367581 ctcacgaaaa gatttcgaca atatctggaa ggcgctcaac cgcaagggaa aagcgaaggg 1367641 ggagctgcct gtcaagcttc gttcaggagt tcaaaaacta tttgaattca cgattacatc 1367701 aaacatcatc agcggttttt atatgtccat tatgagggat atcacagaga agcggtctat 1367761 ggagctgcag ctctttaaaa gtgaggagcg cttcagagaa atctttgaaa atgcaatgga 1367821 cgccatcatc atctggtcga atgacggaag aatcgtaaaa gcgaatcaat cagcctgtaa 1367881 aatttttgag ctgccgatga atttgctgtt gaaaagaaag ctgtgtgatt ttctcgttga 1367941 ctcgcagcag aaatacagca taacgaagag gaaatacgca aaatacggag agatcagaga 1368001 agagctgctg tttcaaatgg ggaacggcca attcaaagag cttgaattta cttcaaaacg 1368061 gacaatcctt gaaaatcagc atttgacgat cttaagaaat gtaagcgaca gaaagcggat 1368121 ggaaaaggag cttcgggaaa gcgagctgaa attcagaaaa gtgttcaacg gatcaatgga 1368181 cggcaatgta ttgttcgaca atcaatacag gatcatcgac gccaacccgt tagcaagcca 1368241 tattttgggc ctgtcacatg aagagatcaa acagcacagc ctgttagata ttatttctgc 1368301 ttatgaaata gaaaatttgg catcaccggc aaggcagatt aattttgatg aaatggacaa 1368361 cgaaattcca tttttgctga gcagcggtga taacagaaaa ctcgaattct catttaaacg 1368421 gaatattatt caaaatatga acttggctat ctttaaagac gtaacagagc gaaaagaatt 1368481 ggaggagcgc ctgcgcaaat cagataccct tcatgttgtc ggcgaactcg cagccggtat 1368541 tgctcatgaa atcagaaatc cgatgactgc tcttaaaggc ttcattcagc ttctgaaagg 1368601 gagtgtcgag ggagactacg ccctttactt caacgtgatc acctcagaac taaagcgcat 1368661 cgaatccatc atcaccgaat tcttgatttt agccaagccc caggccatta tgtatgagga 1368721 aaaacatgtt acccaaatta tgagggacac gatagacctt ctaaatgcgc aagccaatct 1368781 cagcaatgta caaatgcaac ttgatttaat tgacgacatt cccccgattt actgtgaacc 1368841 gaatcagctg aaacaggttt ttatcaatat attaaaaaac gccatcgaag tgatgcctga 1368901 cggcggaaat atttttgtaa cgataaaggc attggatcaa gatcatgttc taatctcctt 1368961 aaaagacgag ggaatcggaa tgacagaaga taaattaaag cgacttggtg aaccgtttta 1369021 tacgacaaag gaacggggaa ctggacttgg gcttatggta agctataaaa ttattgaaga 1369081 acatcaaggc gagattatgg tagaaagtga agaagggaag ggcaccgttt tccatattac 1369141 gcttcctgtc agacagaatg ctgaagaaag aaggaatgat gaatgaacta ctatacgaca 1369201 gccgaaacgc cgctcggtga acttatcatt gccgaagagg aggaccggat cactcgtcta 1369261 tttctcagtc aggaagattg ggtggattgg aaagaaacgg ttcagaatac tgagcataag 1369321 gaaacaccta atcttgcaga agcgaaacaa cagcttcaag aatatttcgc aggcgaaagg 1369381 aagacattct ccctgccgct cagccaaaag ggcactcctt ttcagcaaaa agtgtggcaa 1369441 gcgctggaga ggattccata tggcgaatcc cgaagctatg cggatattgc cgctgctgtc 1369501 ggcagtccga aagcggtgcg cgctgtcggg caggctaata aacgtaacga cctgccgatt 1369561 tttgtcccgt gccacagagt gatcggcaaa aacagtgcgt taacaggata cgccggaagc 1369621 aaaacggaga tcaaagcatt tttgctaaac atcgagcgaa tctcctataa agaaaaataa 1369681 aacatatggc acgttccctt ttttcacggc cgacatatca ttttattaag ttaaaaaagt 1369741 tggtctgatg aaaaaggagg acaaagcaat tgaagccgag ccgctctgag aaacttgccg 1369801 tttttgccga actgtttgtg aaactgcata tcttatcaag cgctcaaaaa gatgaaatca 1369861 tcaatgttaa caaaaagaaa caaaaaaacc gctgactcgg ctccaaatga gcaaagtcca 1369921 gcggtttttt aatgcacctt ttctccttta aacagctgtt caatctcttc ttcatagttt 1369981 ccggtcataa tccctttttc tgtgatgatt cctgaaatga gatcatgagg tgtaatgtcg 1370041 aaagcgggat taaagacagg cacattggat ggagcggtcc gaactccgga aatctgcctg 1370101 acttcctcgg gatctcgttc ctctatcggg atatcagcgc cgcatttgac ctttgtatca 1370161 aatgtagata aaggtgcggc gacaaaaaac ggaatatcaa aggcgtttgc taaaatagca 1370221 agaccgtatg tgccgatttt atttgccgta tcaccgttct ttgcaattcg gtcggctccg 1370281 acgataacag cggaaatttg tttttccttc atcgtatggg cggccatgct gtctgtgatc 1370341 agagtgacat caatgccccc ctgcatcagc tcccaagcag taaggcgtga accttgcagg 1370401 acaggccttg tttcacaggc ataaatgtgt aatcccaaat ctttttgttt ggccaagtaa 1370461 aacggagcta gcgccgttcc atagcggctt gtcgcgattg agccggcatt gcagatcgtc 1370521 atgatcctgt cgcctttttt gaaaagctgc agggcgtttt ggccgatcaa ccggcacgtt 1370581 tcctcatcct cgacctgaat ctgaatggct tcatggacaa ggtttgtttt tgcttcattt 1370641 acggaaatcg cgttttcgac cgaatgactc agtctctcaa gcgcccatga caaattaatg 1370701 gcggtaggcc gtgagctgtt taaatattgt ttgatgtctt ccagtctgcg gcggaattcc 1370761 gtgacattgt ctgtttcaat gtctttggca gcaagcgcca gtccgaaggc agctgtaatg 1370821 ccgatcgccg gagcgcccct tactttgagc gtgacaatcg catcaaatac atcctctttc 1370881 gtcgtcagct ccaaatattc cgtctcatca ggaagctttt gctgatttaa aatggtaata 1370941 gctgtttctt tccattcaac agaacgtgga acagcaaatg aatgggtcat gaatagatca 1371001 ttcctttaca agtaacttaa ataattcaat aacatctgtt atcgttttga attccgaacg 1371061 tttttcgata aaggctgtgc cggtttcgag cgccaagcgt tttctgccga ttcgtttatc 1371121 aaacggcacg atcgtatcca ggtcagctac atgggcaagg ccgatcgtgc gtcgtatcag 1371181 ctcacagccc gcaaatccga ttgcttcttc aaaaatatgg ctgagcgtat cagtgaggta 1371241 accgtcgatg ttggcgtaaa catccagact gtccttctgc caggcttcac taaacgtctc 1371301 ttcaaacgtt tcccagacct ggttgacatg ttcatataac ggctctctgt cagccccgtc 1371361 acggctgagt gcgttcaaaa ataagttggc gataaattgc cctacatcaa agccgatcgg 1371421 tccgtaaaaa gcaaactcag gatcaatcac ctttgtttcg tgctcacttg cgaaaatgct 1371481 tcctgtatgc aaatcaccat gaatcaacgt ttctgcagac gttaaaaatg actttttcag 1371541 cttagcggct tcgattttaa cgctgtcatt attccaaagc ttttcgacaa aaggacgaag 1371601 ctcttcttca aaatcatttg tgtcatggtc gaagaaagga tctgtaaaaa caagtctttc 1371661 cgtaatgtcg catagctctg gatttgtaaa ctgtttaaca agctgttttt tcaccttagg 1371721 ttcaagcgcg taatctgatg agtagaaaag tgtttttcct aaaaattcac cgatgtgctg 1371781 cgacagatga ggatagtttt caccctcaat gagtcctttt cttgcgatct tgaggtgaga 1371841 gagatcctcc atgacggtaa ccgccatttc cgtatcagaa taaaacactc ttggaaccag 1371901 gtgaggcaca tgctcgccct gacggatgag agcgctgctt tcgattcttg cacggtcgat 1371961 tgtcagcggc cagctttctc ccaccacttt tgcatacgga accgcctgtt taatgatcaa 1372021 tgctctgtca tgttcttgat cataaatatg aaaaacgtaa tttaagttgc cgtctccgat 1372081 ctcctggcat gtcagcgtgc ttttgcttgg aaataggcca agcttcaccg ccaacgccac 1372141 agcggagctt tcatttaacg tttcgtataa aggtgttttt gtgactccca tcatcataac 1372201 ctccaattat gtaattaatt aatatgtggc cgtaaaaaag cctccttctc agagagaagg 1372261 aggcttaaca tctatgtccg cctctcttat ctctcagatc agatctgaat ggaattagca 1372321 ccgtgcctta agagaccagc gtctcggcgc gaaaaaaatg cgccccattt cacaatggaa 1372381 ttacggtcgg ttgcttttgg ggtcaaaagg ccaaatccct cgcccaactc tcgataagag 1372441 aatatattca cttgtttgac aattctaatt tatcagttga tgaacatggt aacaggtaat 1372501 ttagttagtt gtcaatatat tttttaatat aaatcttttc tgatatcatc gaaaacagga 1372561 atgctctccc gaacttctgc gctttcttga aggtcgattt ccgctcggac tatgccttct 1372621 tcccggccgc cttcagcaag tacacgtccc catggatcaa taatcaggct atgtcctgca 1372681 aattcattat ccggatttga accggtacaa ttgcaggctg cgacaaagca ttggttttca 1372741 atggcccgcg caataagcag gcttttccaa tgatcaaggc ggggaagagg ccattccgca 1372801 gaaataaaca gcacgttggc gccttttgtc gtatgttttc tgatccattc cggaaaacgg 1372861 atatcgtaac agatcaatcc agagcttttg acgccgtcaa gctcaaagta tccgtcttcg 1372921 gaaccggctg ataaatacag atgctcatcc atcagctgaa aaagatgggc ttttctgtac 1372981 tctttaatga tttgcccttc cttatccgcg atgtacattg tattataaac atcagaattc 1373041 ttcctgacag cgaccgatcc ggcgacaata tgaacaccat gtttttttgc cgttttcttc 1373101 agccagctct gagcggagcg gccgtcttcg tcagcgagtt catcaagatt ggccagatca 1373161 tatccggtcg tccataattc aggcagaaca agaacatcag catgtttgct ttctttttcg 1373221 atgaaaaatt cagccttttt tatattttcc gaaggttttc cgtatgaaat atcaaattga 1373281 agacaagata tcgtccattt catcttttta acaccccaaa tttttcttta cttttttcat 1373341 ttaaccatat atgatgatgg actatcattt caagattttt ttagaaggtg agaatagatg 1373401 aaatttgaac agtctcatgt attgaaggaa ttgcctaaac aattcttcgc ttctctggtg 1373461 cagaaagtga accgaaagct tgcagaagga catgacgtta tcaatctggg acagggaaat 1373521 ccagatcagc cgactcctga gcatattgtt gaggagatga aacgagctgt cgctgatcct 1373581 gagaatcata aatattcgtc ttttcgcggc tcataccgtc tgaagtcagc ggctgctgca 1373641 ttttacaaaa gagaatacgg cattgatctg gatccggaaa ccgaagtcgc tgtattattc 1373701 ggcggaaaag ccggtctagt cgagctcccg caatgcttgt tgaatcccgg tgatacgatt 1373761 ttagttcccg atccgggtta tcctgattac tggtcgggtg tcacacttgc aaaagcaaag 1373821 atggaaatga tgccgctcgt aaaggacaga gcgtttctcc ctgattacag cagcataacc 1373881 gctgaaataa gggaacaggc gaaattgatg tatttgaatt atccgaataa tccgactgga 1373941 gctgttgcta cttccgagtt ctttgaagat accgtgcgtt ttgcggctga aaacggaatc 1374001 tgcgtcgttc acgattttgc ttacggcgct gtaggatttg acggctgcaa gcctttaagc 1374061 tttttgcaga ctgaaggtgc gaaggatatc ggaattgaaa tttacacgct gtcaaaaacg 1374121 tataatatgg caggatggcg ggttggcttt gccgtcggaa acgcttcggt cattgaagcg 1374181 atcaatcttt atcaagacca tatgtttgtc agtcttttca gagcgactca ggaggctgca 1374241 gcagaggcac tgttagccga tcagacgtgt gtggcagagc aaaatgccag gtatgagagc 1374301 aggagaaacg cttggatcac ggcatgccgg gaaatcggct gggatgtaac agctcccgca 1374361 ggttcttttt ttgcatggct gcctgtgcct gaaggctata cttctgagca gttctcagat 1374421 cttttgctgg aaaaagcgaa tgtggcagtt gcggctggaa acggcttcgg tgaatatggc 1374481 gagggctacg tcagagtcgg acttttaaca agtgaagaaa gacttaagga agccgcttat 1374541 cgaattggca aactgaacct gtttacccaa aaaagcattg acaagacctt ataacgatgg 1374601 gataattcaa aataatttat aaaatctata ttttcttatc aagagcaggc agagggacga 1374661 gcccgatgaa gcccggcaac cgacttataa agcacggtgc taattcttgc agctagcggc 1374721 tgagagataa gattcggacg agaaacgaaa cctctttaga cgcgattgca gtttgaagag 1374781 gttttttgat atggatgaaa atgaaaggag ctctggcatg agtgagttat tagcgacata 1374841 tctcctgacc gaaccgggag ccgatacaga gaagaaagca gaacaaatcg caacaggatt 1374901 gacagtaggc tcctggactg atctgcccct tgtaaaacag gagcaaatgc aaaagcacaa 1374961 ggggcgggtg ataaaagttg aggagagaga gggaactgct gcatcagaaa aacaagcggt 1375021 catcacaatt gcctatcctg aaatcaattt ctctcaggat attccggctt tgctgacaac 1375081 agtgtttggc aagctgtccc tggacggaaa aatcaaatta atcgatcttc acttctctga 1375141 agcatttaag cgtgcactgc cgggaccgaa gtttggcgta tacggcatcc ggaagctgct 1375201 gggagagttt gagagaccgc tgttaatgag catatttaaa ggcgtaatcg gaagggacct 1375261 gagtgatatt aaagaacagc tccggcagca ggcgcttggc ggagttgact tgattaaaga 1375321 cgatgaaatt ttctttgaga ctggtctagc gccttttgaa acaagaattg cagaaggaaa 1375381 gcaaatattg aaagaaacgt atgaacaaac cggacataaa acgctgtatg cggtgaattt 1375441 gaccggacgt acggctgatc tgaaagacaa agcgagacgc gccgccgaat tgggagcgga 1375501 tgcgcttttg tttaatgtct tcgcttacgg cttggacgtt atgcaaggcc ttgcagaaga 1375561 tcctgaaatc ccagttccga ttatggcgca tccagcagtg agcggagcgt ttacgtcttc 1375621 tccgttttac ggtttttctc acgctctttt actcggaaaa ttaaaccgat attgcggtgc 1375681 tgacttcagc ctctttccgt ctccatatgg ttcggttgcg cttccaagag cagatgcact 1375741 ggcgattcat gaagaatgtg tgagagagga tgcttttaac caaacatttg ctgttccgtc 1375801 agcaggcatt catcccggca tggttccgct attaatgcgt gatttcggca tagaccacat 1375861 tattaacgcc ggaggaggcg tacatggaca tccgaacggt gcccaaggcg gggggcgagc 1375921 gttcagagct attattgatg cggtcctaga ggcccagccg attgatgaaa aagccgaaca 1375981 atgcaaggat cttaagcttg cgctagataa atggggaaag gctgaagccg tatgacgact 1376041 cgaaaacctt ttattatttg tgattttgac ggaacaatca cgatgaacga caacattata 1376101 aatatcatga aaacatttgc tcccccagag tggatggcat taaaagacgg cgtactttcc 1376161 aaaacgctgt caatcaagga aggtgtcggg cggatgttcg gccttctgcc cagcagttta 1376221 aaagaagaga ttacaagttt tgtattggaa gatgcaaaaa tcagggaagg ctttcgggaa 1376281 tttgtagcat ttatcaatga gcacgagatt ccgttttatg tcataagcgg tggaatggac 1376341 ttttttgtat atcctttgct tgaaggcatt gtggagaaag accgcattta ttgcaaccat 1376401 gcttcatttg acaatgacta tatccatatt gactggcctc attcctgcaa gggcacatgc 1376461 agcaatcaat gcgggtgctg taagccgtcg gtcatccatg aactttctga accgaaccaa 1376521 tatatcatca tgatcggtga ttcggttaca gatgtggagg cagcaaagct gtctgaccta 1376581 tgctttgcaa gggattattt attaaacgaa tgccgggagc aaaacctcaa tcatcttccg 1376641 tatcaagatt tttatgagat cagaaaggaa attgagaatg taaaggaggt acaggaatgg 1376701 ctgcaaaaca agaacgctgg cgagagctcg ctgaagtaaa acgggaattg gcagagagag 1376761 attggtttcc ggcgactagc ggcaatctgt caattaaggt tacagatgag cctttaacat 1376821 ttctcgtcac tgcaagcgga aaagataaac gcaaagagac ggttgaagat tttctgctgg 1376881 tcgatcaaaa cggagagcct gctgaaagcg ggcattctct gaaaccgtca gcagaaacgc 1376941 ttttgcatac acatttgtac aataaaacca atgccggatg ctgcctgcat gtccatacgg 1377001 taaacaataa tgtgatttca gagttatacg gagaccaaaa gaaaatcaca ttcaaaggcc 1377061 aggaaattat aaaagcactc ggcttgtggg aagagaacgc agaagtgacc gttccgatta 1377121 tagaaaatcc ggcacatatc ccgacgctag cggcactgtt tgcggaagag atttcagaag 1377181 attcaggagc tgttctgatc cgaaatcatg gtattacggc ttgggggaaa acagcatttg 1377241 aggcaaaaag agtgcttgaa gcgtatgaat ttttgttcag ctaccatttg aaattgaaaa 1377301 cactcgagca tcagctggtt aaataaaagg aggaattgaa atggctacaa ttcgaattca 1377361 tgatgaggca aatacaacga ttgaaaatca agaggaagtg gcaagctttc tggacagtca 1377421 agaggttatt tatgagcaat gggatatcac gaggcttccg gaacatctct cagagaaata 1377481 tgacctgaca gaagaagaaa aacagcaaat tcttgatacc ttcgaaactg aaattaaaga 1377541 tatctcaacc cgccgcggct ataaagcaca ggatgttatt tcattgtcag acagcaatcc 1377601 gaaacttgat gaactgcttg aaaactttaa aagagagcat caccatacag acgatgaggt 1377661 tcgttttatt gtaagcggac acggtatttt tgtcattcaa ggccaggacg gcacgttttt 1377721 tgatgtccgt ttaaaccctg gagatttaat ctccgtgcct gagaatatcc gccattactt 1377781 cacgcttcag gaggaccgca aagttgtcgc ggtgagaatt tttgtcacaa ctgaaggctg 1377841 ggttcctatt tatgaaaaag acagcgtgaa tcaataagcg tgagatagcc ccgttcatcg 1377901 aacggggctt tttatattta ttgcaaacgc cacttttcat attgtgacag ttctttttta 1377961 atcagtgtcc aaatcaaacc taaaacagct gcatcgtcaa tgaatccaag accgaggatt 1378021 acgtctggaa tgatatcgag cggcatgacg atatacagga ttgcggcagt taacagcaaa 1378081 agtgttttaa cctgtgaacg agggtagtcg ccatttcgcc aatcgcgaag catctgaaaa 1378141 aaagtagtga tgtgctggat acattttttt cggtttttcc tctttaaaat cgcttttccg 1378201 cctgccgctc cgagcattat tgctttcttt ttcttcattg ggcatacctc ctgcctggcg 1378261 gcgtgtttaa gatattcttc acctgggtat tgttcttcta atcctatcaa tatatctatt 1378321 atacctgaaa aattaactta tttaatgaaa atatgtttac aaataaagta taatctgtaa 1378381 taatgcacaa taacccaatc aaacttgttt cctatttctt agcggcgagg ggtgaagtga 1378441 atgggcggtt cttctgaaca agaaagattg ttggtgtcta ttgatgaaaa aagaaagtta 1378501 atgatagatg ccgctagaaa gcagggattt acagggcatg acacgatcag gcacagtcag 1378561 gagctggatt gtttaataaa tgaatatcat cagcttatgc aagaaaacga acattcccaa 1378621 gggattcaag gccttgtaaa gaaattaggc ttgtggcccc gcagagatgt tatgccagca 1378681 tatgatgcaa ataaatagcg gcctatcaga tgcatatata aagagagagc ttttcggaag 1378741 cgctcttttt ttctggaaaa aattcatatg aaagagggaa ctaatgaagg aactggcgat 1378801 tctcattacc gaaatggtca atcaatttca tgatgctttt atttccttat gcggaatatt 1378861 tggcattcat ttaactgaca aagaaatgca tttttgggtg atcggcattt ttggcatatt 1378921 ctttttcggc gtcactcacg ctgtgtttac atggctttct aaatggagta tgacagcctt 1378981 gtcctttatc tataccgtta cagtcatcat tgtcatcgta tttgcgattg agattcagca 1379041 aaaggtgacg gggagaggga atatggagtt tttagatgcc acggaaggta taaagggttt 1379101 tttagtattt tttatgtttt ttttgctttt gaaaatgctg ttgcgtttca tcaaaatcct 1379161 tttttctgga agaccagcaa gcaaatcgaa tggcaatgcc cgatcacgaa gataaaaaac 1379221 cctcctgaca tggtcagggg ggctatgatg cggatacggg gagggtgatc gtcacctctg 1379281 tgcctcttcg cacttcactt tcaatatgaa tagagcctcc gtacatcagc acgatccgtt 1379341 tacaaacaac aaggccgaga ccggttcctt tttctttaga agtaacaaag ggaaggaaga 1379401 tgtgatccag catttcctga gaaatccctt caccgttatc cacaactttg attatggctt 1379461 ttttatctaa agctcctagg gagatcgtca gtttgcctcc ttcaggcatt gactcgaggc 1379521 cattttttgc tacatttaaa atcacttgtt taatatgatc ttttgtacat tttacgagta 1379581 agggctgctc ggttagatac tgtaattcga cttcaacatt gtatagattg ccctcagaat 1379641 aaatgatcgg cataatttct ccgataatgt cctgaagtga gttcagctcc catttttcag 1379701 ctgtcggctt gccgagaacg agaaactcac tcactatttg attgatgcgc tttatctcct 1379761 gttcgataat ggagaagtaa agctgatctt cctcaccttt atatttcttt tgcaacagct 1379821 gaataaagcc gcttatcccg gtgagggggt tacggatttc atgggctgtg ctggcagcaa 1379881 gcgtcccgat cagctctaat ttttgcgcct cgttttctga gcgctccagc tgggtctgcc 1379941 gcttcagcaa ataatacagc acgagaataa aaaggatatt cagcagaaca ataatacatg 1380001 aaagcggaag cacaaggctt ttcgacagtt cttctattgt gaccgggttc ggatagactt 1380061 tcatattcca gctgatatca tccagatatc cgctgacagg tttctgatcc tctgcatgag 1380121 aggcttgtcc gctcgcaaaa atcattttcc cgtcttggtt cacaacttca atataaacat 1380181 cagggcttag taagttaatg agatttttca aataatcaat ttgaatagct gcgacaagat 1380241 aatctgtcac attacgtttt gagtccaaaa caggcacaca aattgtgaaa attggctgac 1380301 cagtaattct gctcgaataa ctatctgaaa tgactgtctt tttagtttcc tttgctttta 1380361 taaaaaaaga tctgtcggcc aggtttactt tcgtttttaa ttcggttgtg cttgcggtga 1380421 cgtctccttt ggcattgaga aaatagagac cggaaaatct cggctctgaa tcaaaggtct 1380481 tttccaaaat tgattgcatt ttctttatat caaccggtct gtcgatggcg atggacaagg 1380541 aggtcattct cgccattgtt tctccgatta aataattgat tttgttgcgg tgaaggttta 1380601 gcaggacact tgcttcttgt ttatgttctg cagctattgt atctttttct ttttcatata 1380661 cgaaaaagct gatgacgatt gccggaatca cgaccagtat gatataaagt ttgactctcc 1380721 cgcaggcgcc ttttagtatt ttcaatttgc atcgctccaa catacacctg attagaggta 1380781 ttatatcatt gtttcttctt ctttaataag aaaaaataac caaaaaaatt agaaaaagat 1380841 gttggcaagc ttacatttta aaaaagaaga gaaatattgg aaagattttt attgacattt 1380901 tggtctttgt ttattaatgt ttctctgtaa cggtttctaa aaggatgatt gagacatgac 1380961 agaaaaatca ctgaagttat ttatcgtgct gtcgcgcgcg tatcggtcta ttaacgatca 1381021 tatgaataag catattcata agcatgggct gaatccgact gaatttgctg tgctagagct 1381081 tttgtaccat aaaggcgatc agccgctgca gcagatagga gataaaattc tcttggctag 1381141 cgggagcatc acatacgttg tagataagct ggagcaaaaa gaacttctca ttcggaaagc 1381201 gtctcctaca gacagacgag tgacatttgc gcaaattact gaaaaaggca tcggtctttt 1381261 gaacgatatt ttccctgatc acgctgctga aattgatgaa atgatcagcg tattaagcga 1381321 agaagaggta gagatgtgca ccgaaatgtt aaaaagagta ggattaaacg caaaacagtt 1381381 tcataataag taaaaaaagg aagcctgata tgtcacaagg cttccttttt tgctattttt 1381441 catttgtttc cgctgcgcct ctcggcaaaa tgagaacttc aacccgccgg tttttgcttc 1381501 ggccttccgc agttttattg gaagccaccg gtttatactc gccataaccc ttggcgctga 1381561 acacttttgc atcgagcttg gggttttcaa tcaggagccc cataaagttt accgctctca 1381621 tgacgcttaa atgccagttt gattggaatt cagaattttt aattggcata ttatcagtat 1381681 gtccgctgat aatgatattt cttggcgggt taatcacaag aagatttgaa atctcttttg 1381741 caagcggcac atcttcctta cggatggtcg cttttccaga atcgaagaag atgctgtctt 1381801 taatcgtaat cagaaggcct tcactagtca tcttcgtctc cagctgatgt tccagctttt 1381861 tatctttgat gaacttttcc acctggctct tcacattttc aagttcttct tgatcagctg 1381921 ctttttcttt ttctttcttg tttttctctt tctcttcttt ttcctttttc acttcatcga 1381981 tgccgtctga ctcgttttca ggaggagtga cactggagta gtccagtaca ccggttccgc 1382041 ctgtaaaaac ttcattaaat gattttgaga gcatttgaaa cttagctgcg tcaatcgagc 1382101 tgctcgcgta cagcacaata aacaatgcca ggagaagagt aaggatgtcg gcgtaaggaa 1382161 cgagccatga ttcatcaacg tgctcgtcct catgcttctt cttctttttt ctcgccattt 1382221 tgcgcctctc cttgttctgc aaatttcaag cggtccttcg caggaagata cattaaaagc 1382281 ttttgttcga tgactttcgg tgcttgtcct tctaaaacgg ataaaacacc ttcaatcatg 1382341 acctcacgca gttttacttc ctgttttgat tttcgtttta atttatttgc gaaaggatgc 1382401 cataacacat accctgtaaa gataccgaga agtgtggcaa caaaggcagc actgatggcg 1382461 tgtccaagct catctgtgtt atccatatga gagagagcgg caatcagccc gattacagcg 1382521 ccgagtactc caagtgtcgg agcgtacgtt cctgcttgtg taaaaatagc ggctcctgct 1382581 tggtgcctgt cctccattgc ttcgacttcc tctgtcataa tatctcttat aaattccgcg 1382641 ctttgcccgt caacagccat gctgagcccg tttttcaaga aagcatcatc tacatcctca 1382701 atgcttgctt ctaaagcaag cagaccttcg cggcgtgcaa gctgagccca ttcagagaac 1382761 ataggaatga gttcctctat tgtgagctgt ttattttcct taaataacac tcgaaacagc 1382821 gtaggcactt ttttaatttc ttttgttggg aacgcaataa cgactgctga gattgtcccg 1382881 gcgataataa ttaaaatggc agcggggttt gcaagggcgc tgaaactgac gcctttcaga 1382941 accatcccga cgctcaatgc cacaaaagca agaataatac cgattaacga agttttatcc 1383001 atagttttca ccaaatcctt ttttactagc ttgtctatgg ttaatatcgg ttttggtgcc 1383061 cggaacttta gggacattgt gaatttgttc atgaaatatt caaggaagag gcatagaagg 1383121 gagaaataaa caaaaacggg ctctccaaaa ttgaaaagcc cgggggtcta ctgaaattag 1383181 cagcttgctt gcaagctgtc cttcagatgg tattcatata atagtagaaa tacatattca 1383241 ctgtatataa acatgttcca tccctcctta aaaaagtgta aaggatgaag ggaagtagcg 1383301 cttcaggaga agggacggta atttctaagt caagagtatg aaagtataaa aaaaagcggc 1383361 ttcctaaaag gaaaccgctg attgttattt tgctcgcact ttgattttat catcttctaa 1383421 aatcacgtga aaacttgtga tctcgccatt atcaagcagc agatcggtca tttcatcctc 1383481 aacccattct tggatggttc ttctaagcgg acgtgcaccg aatgaagggt ggtagcccag 1383541 ctcagcgatt ttttctttcg cttcatctgt cacattcaag ctaatgcccc gttccgccaa 1383601 tgtttcttca agttctccaa gaagaaggct gacgattttg acaagatgtt ctttttccaa 1383661 tgagcggaac tcaataatgc tgtcaaaacg gttgaggaac tcaggtttaa agaacatgct 1383721 cagtgaatca attaatgttt gttcttcgat gacactgtca tctgattgga aaccgacttt 1383781 cgtttgtttc tcaccagcac ccgcattact tgtcatgatg atcacagtgt ctttgaagct 1383841 tacagttctg ccttggctgt ctgtcagacg gccatcttcc ataatttgca ggaacatatg 1383901 ctgaacgtct gggtgtgctt tttcaatctc atccagcaac acaatgctgt aaggattgcg 1383961 gcgcaccttc tcagttaatt gtccagcttc ctcatggccg acatatccag gcggtgaacc 1384021 gataatttta gatacggcgt gtttctccat gtattcgctc atatcgagtc ggataatagc 1384081 gtcttttgtg ccgaataatt catctgccag tgttttagaa agctctgttt tccctacgcc 1384141 ggtaggaccg acgaagagga aggagccgac tggtctgttt ttggatttta atccggcgcg 1384201 gcttcgtctt accgcttttg ccactttttg aacagcggct tcttgtccga tcacgcgttc 1384261 atgaagtttt gcttcgagtt ctttcatttt cgtttgttcg tctgcctgca gtttgccgac 1384321 agggatgcct gttttttgtt caacaatttc ctgaatgtgc tcagcttcca cagtgacagc 1384381 ggtatgagcg gaggagctgt tcagtttttt ctccaatgcg agttcttcat cacggagttt 1384441 tgccgccagt tcgtaatttt cttcttccag ggcttttgtt ttttcggctt caattgcagt 1384501 taagcgttca gcggcatcct catcattcag ttcatcaatt aacaggttgg cttttgaacc 1384561 tgcttcatct aataaatcaa ttgctttatc cggcaggtgt ctgtcctgaa tgtagcggga 1384621 tgataaagtg acacatgctt tgattgcttc atcactgaat gttacgccat ggtacgcctc 1384681 gtatttgtct ttaatccctt gcagaatgag gatagcctgt tcaattgaag gctcctgcac 1384741 catgacaggc tgaaaacgtc tttccagcgc ggcatctttt tcgatttgac gatattcttt 1384801 cagtgttgtc gcgccaatga cttgcagttc gcctctggct agggccggtt tgagaatgtt 1384861 gccggcgtcc attgatcctt ctgcagagcc tgcgccgacg agaaggtgaa tttcatcaat 1384921 gaacagaatg acattttttc gttccttcag ctcagtgatc agctgtttca ttctctcctc 1384981 aaattggcct ctgatccctg tgtttgcaac aagagatgca acatcaagca agtatagctc 1385041 tttgtttttt agtttgtttg gaacatcacc ttcagcaatt tttaaagcga gcccttcagc 1385101 gatggcagtt ttccctacac ccggctcacc aataagaacc ggattgtttt tgtttcggcg 1385161 gtttagaatt tcgatcactc gcgccacttc atcatcacgg ccgatgacgg gatcaatgag 1385221 accggctttt gcaccgtttg taatattttg agccagctca tcaagcaacc cttttttttc 1385281 gctttgtttt gctgcgctct gttctttcgg ctggaatgcc tgttcaaacg gaaatccgaa 1385341 agattgagga cccatactca ttgaaggttt acgggtcagt tcgttatagc aagtttcaca 1385401 aagaaccatc tgtttatgaa cggaatttat ttgcatgtta aggcgaatcg tcgcctcgtt 1385461 ttgatgacaa tgttgacaac gcatttgcca aaacctcctt aataatttga tcatctttga 1385521 ccaatgaaag tgaataaaaa ggtctattgg gtttgacctt ctttgactat tagtatacgg 1385581 caaacttaac ggcattcaaa ccaatatgct caaagcagac tgaatatttg actatctttg 1385641 accaattgat ttttaaaaaa ggccggtttg tttgaccaac tttgattaat agtatactct 1385701 gactatcttt gactttcaag tcttatgcac aaaaattttt gatttgttac aaagtaaaac 1385761 atgttttctt cgtcttttca aggaacttgt ctcataggtt ataaaaaggc atatatggac 1385821 aaaactgcgg ttcgttcgga gggaagaaat ggaacaatca aaagggtctg caagtcagct 1385881 tgcttttgtg tatgtcggca cagtagtcgg agctggattt gcgactggga gggaaattgt 1385941 tgagtttttt ctgaagttcg gctggttcgg ttttttcggc attctcgtca gcggcggaat 1386001 gtttacgtta ctgggggcca agctgatgat catttcaaag cgaatcaatg ccaagtcata 1386061 tcaagaaatg aacatatttt tgttcggggc gacggctggg cggattatca atgtatttat 1386121 gctgtttgtt ctccttggag ttacatctgt tatgctttca ggggcagggg cgctttttga 1386181 ggaacagctg gggatgtccg ctcagattgg gatgctcatt acaatcggtc tgagtttaat 1386241 tgtgatgact agaggagtaa aaggcatttt cggtgtcaat gtgtttgttg ttcctctttt 1386301 aatcatcttt tcaatgattg tggtggccga ctcttttata ttcagcgaat cacgaaacgc 1386361 agctcagtgg gtctggccgc atcgctggga ttggctgtta tcagcagttt cttacggggc 1386421 tttaaattta tcgcttgccc aagctgtttt ggttccgctg gcgaatgaaa tgtcatcgga 1386481 gaaagtgata aaaaaaggcg ctttaatcgg aggcacgatg ctgacgattg tgctgtccgc 1386541 gagttttctg tctttgtcga ctcttccgga tgtatttttg tatgatatac cgatggcgca 1386601 agtggtttat ctctttgcac gatctgtcca tttgatttat ttactcatta ttttcggaga 1386661 agtgttcaca tcagttatcg gtaatctata tggattagaa aaacaagtgc aaagctttct 1386721 tccagtgaaa agcaaatata tctttgcagc cattatgatc acggcttata ttacgagcca 1386781 aatagggtac ggcaggctta tttcaacgat ttatcccttg tttggctatg tgagcctggc 1386841 cttcataggc gctttgcttt gcaaaaaagc tcctcggcgg cgcagtttat aaatatatat 1386901 aatgaaacga accgtcacta tagagcgata attgatctag gaaccgggga ctgacttttt 1386961 tattgtcaag aaaaacatca ttatggtaag atagcagaag tgaaaaaatt gaagaaaatc 1387021 cgtgcgatat gcgggagagg ttctagctac accctctata aaaaactaag gacgagctgt 1387081 atccttggat acggcctttt ttatgttttt ctagagcacc ttccgaaaaa aggtgttttt 1387141 ttgcgtgaat tagctgtagc gatgtctctc gccggcgttt ttattgcgga gaaggagagg 1387201 aatcatgaaa aaagaaaaag caattgtcgt atttagcggc ggtcaagaca gcacaacatg 1387261 cttactgtgg gccttaaaag aattcgaaga agtcgaaacg gtgacttttc attataatca 1387321 gcgacattcg caggaagttg aagtggcaaa atccattgcg gaaaagcttg gtgtgaaaaa 1387381 tcatttgctt gatatgtcac ttttaaatca gcttgcaccg aatgccctga ctagaaatga 1387441 tattgagata gaagtaaaag acggcgaact gccatccaca ttcgttccag gccgcaattt 1387501 ggtattctta tcctttgcgt ctatcctggc ttaccaaatt ggcgcgcgcc acattattac 1387561 aggagtttgc gagacagact tcagtggtta tcctgactgc cgtgacgaat tcgtgaaatc 1387621 ttgcaatgtc acggtaaatc tggcaatgga gaagccgttt gtgatccaca cgcctctcat 1387681 gtggctcaat aaggcggaaa cgtggaagct tgcagatgag cttggcgcgc tggattttgt 1387741 gaaaaacaac acgctgacat gctataacgg catcatcgca gacggctgcg gcgaatgtcc 1387801 ggcatgtcac cttcgttcaa aaggttatga agaatatatg gtgatgaaag gagagcgtgc 1387861 ataaattgtt atctcaaatt tatccgcagg cccagcatcc ttattcgttt gaactgaata 1387921 aggacatgca tatctcagcc gctcatttta tccctcggga aagtgcggga gcgtgcagca 1387981 gggttcacgg gcatacgtat accgtaaata taaccgttgc cggcgacgaa cttgacgatt 1388041 caggctttct tgtcaatttc agcgtactca aaaaactggt gcacggaaac tatgatcaca 1388101 cgctattaaa tgatcatgaa gatttttctc aggacgaccg gtattcgctg ccgacaactg 1388161 aagtcgtggc gaaaacgatt tatgacaacg tacaggctta tttagacact ttggagaata 1388221 agccgacctg tgtacaggtg tttgtccgtg aaacaccgac aagctactgt gtctaccgtc 1388281 cgaaaaaggg tggtttgaat ggctaaagga attcctgtat tagaaatttt cggcccgacg 1388341 attcaaggag aaggcatggt gatcggacag aaaacgatgt tcgtccggac agccggctgc 1388401 gattattcct gcagctggtg tgactccgct ttcacttggg acgggtctgc taaaaaagat 1388461 attcgctgga tgacggcgga ggagattttt gcggagctta aggacattgg gggagatgcg 1388521 ttttctcatg tgacgatctc aggcggcaac ccggctctgt taaaacagct ggatgctttt 1388581 attgaactgc tgaaggaaaa taacatccgt gcagcgcttg aaactcaagg gaccgtttat 1388641 caggattggt ttacgctgat tgatgacctg acaatttctc caaaaccgcc aagctcaaaa 1388701 atggtaacga actttcaaaa gcttgaccac attttaactt cacttcaaga gaatgataga 1388761 cagcatgctg tcagcttgaa ggttgtcatc tttaatgatg aagatctgga atttgccaaa 1388821 actgtgcaca agcggtatcc gggaatcccg ttttatttac aagtcggaaa tgatgacgtg 1388881 catacgacag atgatcagtc actgattgca catttgcttg gaaaatatga agcgcttgtt 1388941 gataaggtag ctgtcgatgc ggagctgaat ctcgtcagag tgctcccgca gctgcacacc 1389001 ctgttatggg gcaacaaacg cggagtataa tagaaaggaa gatgaacatg acgacaagaa 1389061 aagaatcaga attagaaggt gtaacattgc taggcaatca aggtacaaat tatttgttcg 1389121 aatatgcacc ggacgtgctg gaatccttcc ctaataaaca tgtaaaccgt gattactttg 1389181 taaaattcaa ttgcccggaa ttcacatctt tatgtcctaa aacaggccag cctgactttg 1389241 cgacaatcta catcagctac attcctgatg aaaaaatggt tgaaagcaaa tcattaaagc 1389301 tgtatctatt cagcttcaga aaccatggtg acttccacga ggactgcatg aatatcatca 1389361 tgaacgactt gattgaatta atggacccgc gctacattga agtatggggc aaattcacgc 1389421 caagaggcgg aatttccatt gatccgtaca caaactacgg aaagcctggc acgaagtatg 1389481 agaaaatggc cgaataccgt atgatgaacc atgatttgta tccggagaca attgataatc 1389541 gttaattatt ccgttgtgtg atacggagtg taaaaggaag tggagtcaca gtaaaatccg 1389601 aacattcagc gttaattttc agcggaaatg tgacctggtc acagcgaagt gtgacccgca 1389661 ctaagctcaa taaaagtggg aaaagtcaca cctgaaaatg gctctactca tgggaattgt 1389721 attaaaaagt gtgacctgag gtgcaacctg aactgtgact tttatgcagt gaaaaattga 1389781 tagtacagaa gcagattaag gcgtacaatt tgtacgtctt ttctttttta tccgaaagaa 1389841 aaaatgccta tctagagatc ataggcatta aatattatta tcaatatctt catttatttt 1389901 ttggctaagt ttctgaacct tctctttaac atttgaaaca gctctttttt gaatttcatc 1389961 aattctcctg aatatagtcg atgacacttc ttattagaac ttcactttca aaattgaata 1390021 tctcatttat ttctgactgt tcttcatctg ttaggtgatg gtattgaagt tgtttagcat 1390081 ttacttcagc agctacatca atcctaactt agttgttctg gttgtacaat ttcatattca 1390141 ccttctgcat actcttgctc cgcataatag cctccccatt gacagagctc ctgcaagata 1390201 ggtttaagag attctccaag ttcagtggat gaatattcaa ccttcggcgg tacttgatta 1390261 tacatctttc tgctcacaag tccactggct tcaagctctc taagtgtttg aatcagcatt 1390321 ttctgagtta tatttgggat aatgcgcttt aattcactcg ttctctttgg tccattcatt 1390381 aaaaagtata atacaaggcc tttccatttt ccgccaataa cttcctttgt cacttcaaac 1390441 ccacagctaa attttttcat gtctaaagct ctccattcca catttattac tttttagtta 1390501 ctatatcaca aaaaagtggg tacttccgat aatgtgctta ctgaaggata ctatatcttg 1390561 taagttgttc ttcaagtact taaaggtact agacataaaa taaaattaat tctaaaggag 1390621 tgttaagtat gggtaaattt gaaggtaaaa tagcgcttgt aacgggtgga acaagtggga 1390681 ttggtcttgc tacagcacaa aaatttgtaa acgaaggtgc atatgtttat attacgggac 1390741 gtagacaaaa cgaacttgat aaagctgtta accaaattgg caagaacgta accggtgttc 1390801 aaggtgatat ttctaagctt gaagacttag acaaactata tgacattata aagcaggaaa 1390861 aaggtaagtt ggacattctt tttgctaatg caggcatcgg caacttcctt ccattaggtg 1390921 aaattactga agagcaggtt gatagaacgt tcgacattaa cgttaaagga accatcttta 1390981 ctgttcaaaa agcgttatca ctattcccgg acaaagtagg ttctattatt gtaacgggct 1391041 ctactgctgg atcaattggc aacccagcgt ttagtgtata tggagcatct aaagcagcat 1391101 taagagcact agttcgcaac tggattcttg acctaaaagg tactgaaatc cgtgtaaatg 1391161 tggttagtcc aggaggtatt cttacacctg cctacgatga gctttttggt gatgcacttg 1391221 aagaggtact ggaaaatagc agaaatactg ttccagctgg aaaagttggg acacctgaag 1391281 aagtagcaaa cgctgtatct ttccttgctt cagacgaaag cagttacttg acgggtgttg 1391341 aattgttcgt agatggcggg ctagcacagg tataatttca ctgcgcagag attacaaata 1391401 gtccccaaaa aaggttaatg gggatttact tgaagaagtc gtataaaaaa gtcgttttcc 1391461 ttaaaggaca gggaattcga cttttttata tttgaatttg attaacgttg taaattcgca 1391521 ttttcctggg gctactacta aatgacctgt aaaaaagatt acactgtgaa taaatgtact 1391581 taaagtaacg ggggctcttg acttttaata aaaaataata tccctgtcct tgtattctaa 1391641 tacttttaaa aatatttaaa ggaatcctta tgtcctgaat aaccacatag gaaaatatgt 1391701 tgtaggttgc tttctttttt tgtggggcat cccacacaag ctatctcgtg atctcacacc 1391761 tgaacgtttt ttatagacta gtaccgcgac aagttatatt acatatacat accaataaag 1391821 tagacattaa aaagtgaaag agaggatgga aatgtgtgaa aattcttttc cttgagagtc 1391881 atcccatgtg gctctatggt ttaccgaatg ggtttaggga agcaggacat accgtaatga 1391941 tttccggtcc tgtaagtcgg gaaaatataa ctgaaatgat agacgaattt aaaccagatt 1392001 taatagtatc tatgggatgg acaccagagc attcaaggga aaagcaggcc tggattcgca 1392061 acgctactaa aaaggtgaat atccctctcg tttattgggc aactgaagac ccgctgcaca 1392121 ctcaaaactt tactatcccg ttaattaaaa agatgaaacc ggattttgtt ttcacggtca 1392181 cgccttctct gtgtaaaact tatgaaagca tggggattaa agcagctcac ttagactttg 1392241 catttcacga aagtatacat caccagatta aaccattagc gaaatacagt tgtgatatag 1392301 cagtggtggc taatgcttac cctaattttc ttgaagaaca tccggaagtg ttccgttcgt 1392361 cctctttaaa aacgcttatt cgtcctctta tacggaaggg tattcgcatt gatttttggg 1392421 ggagaaactg ggaaaaaatg agtaaatata taggaagaga aattccccgc aattggatcc 1392481 atggatacct tgattatact gaagcatata aagtttacag ttcagcaaaa atcattatcg 1392541 gtttgcaaaa ctgtgaaagc caacttacac aacgcaccta tgagattctt ggttccgggg 1392601 ggtttttatt gacatcggat acaccagcag ttcgaggtaa attcaaacct ggccgcgatc 1392661 tcatcgtttc ttcctcccca aaagaaacat tggaaaaggt taaatactat ttaaatcatg 1392721 atagcgagag aaaaaagatt cagataaacg gtaaaaaggc tgtaaagaat gattcctatc 1392781 ggcatagagc cgagagaatg cttgaggtgc taaaaagcag aggaatcata agaaacttag 1392841 gggaaaccat tcattatgta gatgttctca aagaaaaata cgtgatccat catgttactc 1392901 ccggtgaaac attatcaata attgccagta agtataatgt ttccctgcag caactcatgg 1392961 agcttaatca tttcaaatca gatcaaatat atgctggaca aatcattaag attagagaga 1393021 aactgtttag aaatattaat aacaaattat tctaaaggag agtaatatga atgaagggga 1393081 aaatacctaa aataagaaat caagcgaata aagtaaaaag aacgcctcgt tatatggaat 1393141 ttcccgtgac atacgaagta tatcatgtgg aatccggcga tacattatgg acgattgcca 1393201 aatcctttga aattccggta caacaactta tgaatcttaa taagctttct tcagatagaa 1393261 tttatcctgg acaaattata aagataagag aaagataatc tttgaggttt cggaagcgaa 1393321 tcaaattgaa atgacaatcc tcattttttt atttgtgggg aacttgatat ttttggggat 1393381 gaaggggtta tgagatgttt caaatgagct attactattc tggattagga tgggacttta 1393441 ttcaacacgt tgatcaaacg aacggagtat taaatgttgt gtctcctgat tttttctata 1393501 tcagaaaaga tggatcatta cttctccgtt cagctaatcc cgatgtgatt aaagctcttc 1393561 atagaagaaa attaaaagta gttccttttc taagcaatca ttgggatcag gatttgggac 1393621 gatttgcatt aatgaaccga gttcttttag ctaaacaaat ttctcatgca atagaagaac 1393681 tggatttgga tggagttaat atcgatatag aaaaccttac agaaaaagat cggaatctat 1393741 ttacagattt tattagatta gtaaggaaaa gtattcctag acataaagaa gtatcagttg 1393801 cagtggcggc aaatcctttt ggctggacga agggctggca cggatcatat gattacgagt 1393861 atttagctaa atatgcagat tatcttatgg ttatggccta tgatgaaagc cgccttgctg 1393921 ggcctactgc aagtgtagga tgggtggaaa agtccattca atatgttctg acccaaaaaa 1393981 tctctcctca aaaactagtt ttaggattgc cattctatgg ccgctgctgg atggaaggcc 1394041 aatctgcctc tcaagccatt cccctttacc ttgttgttag taaaaaggca tagcgggaca 1394101 attatttttg acaccaagag tcaatctcca aaagctattt ttactgtcaa tcacgataaa 1394161 aaggggccgt tgccttcggg aacatataca ttatggtttg aaaatgaaca gtcactcaga 1394221 gcaaaaataa aactcgctca aaaatataat ctgaaaggtc ttggcagctg gagtcttgga 1394281 caagaagatg cgtcagtctg gaatacagtg tttaaaaata tataatgatt tatagttcag 1394341 aacaaaattc gaagataatt gcaatgaatc tctaaatgga catactgaaa ggagtttatt 1394401 acgagtgcgg gtaaaacagt gagggcattc cataggccct tctcccaaaa tgttctacac 1394461 gaggcattac attgggcttg aaatacacat tcaaacttat gttatagtac gcattttacg 1394521 gatgtgttga atttattctg cttccatgat ttaatcatac acatgctact tgatagcagg 1394581 gttatcgcat ttcattcaga attgttcagg atcgatatgg aagcgcacga ctaactagaa 1394641 ctttaaaagc atacactcat atacttcctg aatggatgct ggtttatcta aaaaacatga 1394701 tgagaattga ttgtacgcat ggtgaagcat gacttgttga taatcgacca tatggtttct 1394761 ccttagaaat gagggggttt ttacataaaa aagacgagcg aatccggggg gaattccact 1394821 cgccgctttc taatgaaaag acgggatgct ggatggcagc tcgtctgttt tattataatt 1394881 taacgaacgt atgtttgtaa aggtgtcttt tcgaatgaat tggttcatat aaccgttaag 1394941 aacagattca ttgtaaacat tcgctaaggt atgctaagat gcatggacta taaaggagtg 1395001 atatgaagtg aagacattgc ggttaaacaa tgtaacgtta gaaatggctg catatcaaga 1395061 ggagagcgag ccgaagcgaa aaattgcatt taccttaaac gttacgagtg agacttacca 1395121 tgatatcgct gtcctgttgt atgaaaaaac gtttaatgtc gaggttccgg aacgcgatct 1395181 tgccttccgg ggggaaatga caaattattc aacatcattg accaacctgt acgaaccagg 1395241 ggccgtcagc gagttctata tagaaataac ggaaatagac aaaaacgccg attcatgatc 1395301 ggtgtttttt atgtaaaaaa gctgccggcc ggcagctttt gagaaagcga atttcatatg 1395361 taaggtgtta aattgtccgt cttgcagttt tttgaataaa tgtggaaata aggaggtttt 1395421 aataggagtc tctgatgatc ttataatttt tatgattaac aactgtcaat gaatctaact 1395481 caagatcccg atagttatcc atgatcgtca catcaacgat aacagaattc tcatttactt 1395541 tttcaacaac accggttaat ccgtttttaa attcaatgac attcccaacc ttagcgattt 1395601 tcacaagctt cctctccttt aaacataata atgccttttg aaagtatttt gcagtatttt 1395661 cattgagaag taaagcgata aggagtttta tctcccttat gaattgttct gtcgctataa 1395721 agatgatata ttgattttcg tcaatagaaa gaaaaggggg gaatttttgt tgcgtcccga 1395781 agaaataaca gaaatgattg aacagctgcg caccggcgcc ataaacgaac tgagagtcca 1395841 gaaagagcat tttcttgatt tcagggccgt gttatctaaa caagatgatt ttaaacattt 1395901 ccgaggaatt gcccagcaag gcggagatgt tatctttcaa tacttagaac agccaagaag 1395961 ctgaaggttt ctcatacgtg agaagccttt ttatcatata tgacagaaca caagcctttt 1396021 attacagctg tctgtaacag gtgtaaataa aatgtaaagt accaaagatg gataaacatg 1396081 ttttaattta acaatattta tagaatttca gactgttttt ttgccattaa gcagtgagtc 1396141 atcctcttta ttccatcctg atacctcctt gggagagttg gaaaatcttt ttccgtgaaa 1396201 atgaatggat ctcttgttaa ggttatgaag tgttttttgg agcactttaa ggaggaaact 1396261 gtatgacaac gaaattcact gctctggctg tttttcttct ttgtttcatg cctgcagcca 1396321 aaattgagca tacacaagct tcactactga gcgcaaagaa gacaaaacat gaagaagcga 1396381 aatggcttac acatatagat cgaaatacga atgaatcttt cccttcactg tctgctgata 1396441 aagacaagaa aataaaaccg attaagctat cagcacacac tgaaaagaaa gagaaagata 1396501 aaccggacaa aacaaatgat gagaaagaaa catatacaca gtctgaaaaa gagttgctgt 1396561 cccgtctcgt tcacgcagag gccaaaggag aatcatataa aggcaaggtc gctgtagcaa 1396621 gcgttgtact gaacaggacg gagaaaaaag gttttcctga tacgataaga ggagttattt 1396681 atcagaaaaa cgcctttgaa ccggtcgcaa acgggagcat taaccaaaag cctgataaag 1396741 aatcgattga agctgccgaa gaagcgctgt cctcaaaaaa tagagaaaca gatgccatat 1396801 tcttttataa tccgaaaaca gcgtcagata attggattcg ttcaagaaaa atcgtagaaa 1396861 aaatcggcag acacgttttt gccgtctaag catagaagag acaatttgtc tcagctgtgc 1396921 tttttttcat ataaagagta aaaataaaat aatttttgaa cttgtctcat atgatgttgg 1396981 tagtacaaga gacaaggaga gacatcatga atcgatttgt gaaagggatc attcttttat 1397041 ccattgccgc ctttttcgct gaatgccttg aatttgtcgt caatatgatt ttggcgcggg 1397101 agcttggcga gcatgggatg gggctttaca tgagtatttt gcccacgatc tttttaatta 1397161 ttgtcatcgc gagcctggaa ctgccgatat ccatttctaa attcattgcc gagtcaaatc 1397221 ctaagcttca tgaaagcatg ctgaggcacg ctttcagaat gacagccatt tttactgctt 1397281 tttctactgc cgccgctagt attgcgcttc cgtttattcc ggtatttgat acataccacc 1397341 cgtttattaa agggattgtc atcggcttaa ttcctgttgt cgcctttact tcaatcgcca 1397401 ggggctactt tatgggtgtg cagaaaatgg ggaagatcgc aattgccaat gtgctgaaaa 1397461 aaatcatcca gctcttgtgc ttattcctct tttttcaatg gtactcattt gaattggaca 1397521 tggctgtgct gatttccttg tttgttctag tcgtgagtga tgtggtcgtg cttgtttatt 1397581 tatattcaca atttatcatg gcaaggcggg cgttatccgg ccagcagcac attcatttgc 1397641 gcggaaagga tgtaaggaaa agactgcttg ctgtttcaat tcctacaaca ggactgcgta 1397701 tttttcatgc ggttgtcaat gcaattgaac cctttttagt aaaaggagct cttttggctg 1397761 cgggcgttgc cgggacagcg gcgatcgatc aatacggaat gctggcagga gtggctgtga 1397821 cgatagggtc gttccctgct tttattgccc attcgttaat ggtcgtcatg ataccgagta 1397881 tttcggaagc ttatgcactt tctcagtatg acatcgtgtt aaaaaggctg aagcagtcga 1397941 ttttcattac attaggttac ggtatacctg ccgtctgggt catgttccag tttgcgggac 1398001 ctctcacgca tttgtttttt cactctcctg aagcgcagta ttacttgcag ctgttgtggc 1398061 cttactttct ctttcatctg tttgtcatgc cgctgcaggc gtgcttaatc gggatgggtt 1398121 ttgtgaaaga ggctttttat cacaatgtat ggagccatat cgttgcgcta agtatgatgt 1398181 atgtactggg atcaatggag aatctgcaaa tgctcgggat tatccttgga atgaacactg 1398241 gcatgattct tttgacgagc ctgcactatg ccacgatctg caaagcattg aaggtatctg 1398301 tatttcttac gggagggacc agaacgccgc gaattgaagg atgataaagg aacagcaggg 1398361 gcaagctaat tgaaaagcat gaaaggaaga ttccatgttg acgaagcgct tgcttactat 1398421 atacattatg ttattagggt tgattgcatg gtttccaggt gcggcacaag ctgaggaaaa 1398481 acagcctgct gttcccgctg tttttcttat gaaaacgata gaaggggagg acatctcgat 1398541 tccgaataaa gggcaaaaaa caattctcca tttttggacg tcatggtgcc cgccctgcaa 1398601 aaaggagctt ccacagtttc aatcgtttta tgatgcccat ccatccgaca gtgtaaagct 1398661 ggtaacggtg aatttagtga attcggaaca aaatcagcaa gtcgttgaag actttattaa 1398721 agcaaacaag ctgacgtttc cgattgtcct tgactcaaaa ggggaattga tgaaggagta 1398781 tcatatcatc acgatcccaa catcattttt gctgaatgaa aagggagaaa ttgaaaaaac 1398841 aaaaattggc ccgatgacag cggaacaact gaaggaatgg acggaagaat agctgagagc 1398901 atagactctc agcttttttc atatagagaa gaagtgaata aacattaatg ataattatta 1398961 tcaaaaagaa attaaaataa ttataattga aattctcttc gtgcgtgcta taataaagga 1399021 agacatcaag aaataactga cgataaagct gccttttggg cagcgatttt gtttttataa 1399081 gagaaatgaa gatgatttac gttctcaatt agagaggaga attcgatatg aatgaacaag 1399141 ttatcgttca acgcgacccg catgagccat tgaaaacaga caagagggaa aaaaactggg 1399201 cacagcacgc ggagcttatt gcagcacttg tatcaggcgc tcttattttg gcaggctggc 1399261 tcttatccgg atatcaggta ttatccataa tacttttctt gctggctttt gtgatcggcg 1399321 gatttgctaa agcgaaggaa ggaatcgaag aaacactcga atccaaaacg ctgaatgtag 1399381 aacttttaat gattttcgct gccattggtt ccgccttgat cggatactgg gcagagggtg 1399441 ctattttaat atttattttt tccttaagcg gagctttaga aacatacacg atgaataaaa 1399501 gcagcagaga tttaacgtct ttaatgcagc ttgagcctga agaagcgaca ttgatggtca 1399561 atggtgaaac caaaagagtt ccggtttcag acttgcaggc cggtgatatg attgtgatca 1399621 aacctggaga acgcgtagcg gcagacggta tcattgaatc gggctcgaca agtcttgacg 1399681 agtcggcttt aacaggtgaa tcaatgcctg tagaaaaaaa cacaggcgac actgtattca 1399741 caggaacggt gaatcgcaat ggctccttga cagtccgtgt cacgaaagca aatgaagatt 1399801 cgttattcag aaaaattatc aaactggttg aatcagcgca aaatagtgtt tcacccgcgc 1399861 aggctttcat cgaacgattt gaaaatgctt atgtgaaagg tgtgctaatt gcggtggcgc 1399921 tccttttatt cgtcccgcac tttgcgctgg gctggagctg gagtgaaacc ttctaccgcg 1399981 caatggtgtt tatggttgtc gcgtcacctt gtgcgcttgt cgcctctatt atgccggcgg 1400041 cgctgtccct gatttcaaat ggcgcccgca acggtatgct tgtgaaagga agcgtctttc 1400101 ttgaacagct gggctcagtg caaatgatcg cctttgataa aaccggaact gtaacaaaag 1400161 gccagcctgc cgtagagacg atcagaatag cagaaggatt cagtgaagcg gaagttcttg 1400221 aggctgtcta tgccatcgaa acgcaatcaa gccatccgct cgcccaagcc ataacggcgt 1400281 acgctgaaag ccgcggcgtg aatcagtccg gctacatatc tatagaagaa acctcagggt 1400341 ttggcgttat ggcagaagtg tcgggtgcga aatggaaggt cggtaaagca ggttttatcg 1400401 gcgaggaaat ggcagcacaa tttatgaaac aaacagcatc agatgtcatt caaagcggtc 1400461 atacaattgt atttgtgaaa aaggatgatc aaatagcagg ctgtatcgca ctgaaggacc 1400521 aaatcaggcc tgaagcaaaa gaggtcatgg aagaactgaa ccgacttggg attaaaacgg 1400581 ccatgctgac aggagatcac gaagacacgg ctcaagcgat tgccaaggaa gccggcatga 1400641 caactgtcgt ggcagaatgc ctgcctgacc aaaaagtgaa tgaaatcaaa cggttaaaag 1400701 aagaattcgg aacgattgca atggtgggtg acggaatcaa tgatgcgccg gcactcaaag 1400761 cagcggatgt cggcattgcg atgggcggcg gaacagatgt agcacttgag accgctgata 1400821 tggtcctcat gaaaaacgat ttgaaaaagc tcgtaaacat gtgccgcttg tctcggaaaa 1400881 tgaacaggat catcaaacaa aatatcgtgt tttctctagc tgtaatctgc ctgctgattt 1400941 gtgcaaactt tttgcaggcg atggaattgc catttggcgt gattggtcat gagggcagca 1401001 cgattttagt catactaaac ggtttaagac tcctaaaata aaaccagcag cctaatcagg 1401061 ctgctggctt tttatgtatc aagctttccc ttcatttttg tctttatcag atcttttcat 1401121 aactaggatg agagcgaggg tgcagcaaag gaaacccgct gcacagccta tgatagagct 1401181 gtaataataa aagcccacca tcttcatccc gataaaagga gcggaaattc ccaaaaccgt 1401241 taagagcata actgcttttc gtctgaaaaa attcatcagc aaacggaaca acccccctgc 1401301 gattgaacgt tactgtcagt atacaggaag aggagcagga aataaaatgc attagaaaat 1401361 gaaggcgtcg tgaaaggcaa acaccggtaa aacctgttac aatggaagac agaacaatgc 1401421 attgcaaatg gcagggagga acaagaagtg aatagaatac aacgcgtctc ttcatggctg 1401481 aaggaagcgg ggcatactgc cgcatttatt catacgaaag aaaatgtttt ttacttaacc 1401541 ggtttttaca cagagccgca tgaaagatta atggggttat ttatttttca agaagaggag 1401601 cctttctttg tttgtccagg aatggaagca ggacaggccc gcaacgcagg ctggaatcat 1401661 gaaatcattg gctatgcgga tcacgaaaat ccgtgggagc tgatagagaa ggctttgaaa 1401721 aagcgaaata tcagcataca tatgcttgcg gtagaaaagg attcaatctc gctgtcacgt 1401781 gcagaacagc tgaagcatgc gacgggcggg gctcaatttg tttcagcaga agaaacactc 1401841 aatcaatttc gcctgattaa agatgacaat gagattcgtt tgctgaaaga ggcggcaaag 1401901 cttgcagatt acggtgttga agtcggcaca gccgctttgc gtgaaggcat cagtgaagtg 1401961 gaagtgctcg ctcaaattga gtatgagctg aagaaaaaag gaattcaggg catgtctttc 1402021 tctacaatgg ttttattcgg agaaaaatct ggccagcctc atggaaatcc tggtacagcc 1402081 acgttgaaga aaggtgattt tgttttattt gatctcggtg ttattcttga tggctattgc 1402141 tctgatatta caagaacgtt tgcatacaaa accatcaatc cgaagcagga ggccatttac 1402201 gagactgtgc ttcaagcgga aaaagccgcg attgaggcaa gcaaacccgg tgtgagaatc 1402261 ggagatctgg atttaactgc ccgcggaatc attgaaaaag cgggatatgg tgattatttt 1402321 cctcaccggc ttgggcatgg actcggaatt tcagtccatg agtatccatc aatgagccag 1402381 gccaacgata cactgctgca ggaaggcatg gtctacacga tcgaaccggg gatttatgtg 1402441 ccagagatcg gcggcgtacg cattgaggat gacgttcacg taacaaagga cggagcagtt 1402501 gctctgaccc aatatccaaa ggatttgatc atactgtaat agaaataaaa aaggactttg 1402561 ttctcgacat cgtccttttt tatctgcatt aaataaaaaa atcatcaaat gttcgaaagg 1402621 gtttaatttc atgtttttgg ttgagaggtt ttacagcaag acagctgcca ccgagaacag 1402681 tgagacataa cccaattaaa atgaagaaac ccatgtgatc ttctcctttc agctaaaaac 1402741 acaaaaagat atctggtacg tccatatcat attgtatgaa acgcattcca gatcaagggg 1402801 atttagaaag aagggaatct atggctaata ttaaagacat tgcagagaaa gccggtgtct 1402861 ctgttacaac ggtttcccga gtcataaaca atcatccata cgtcagtgaa gacaaacgaa 1402921 aaagagtgtt tgaggcaatg gaatcattgg agtacacgag aaatattcac gctgtacatt 1402981 tgtcgaaagg attttcaaac atgattggtg ttgtcttgcc gacggttaat ctgccatatt 1403041 ttgcagagct gattgcagga atagccgacg cagccgcgga atccggggtt cacctctctt 1403101 tattccaaac aaactatgaa gtacaaaaag aaatctttgc gctgtcccaa ttaaagcagc 1403161 gccaggttga cggcctgatt ttttgctcaa aggcgcttgc tgatgagaaa ctcatggaat 1403221 gggagggccc gattttgctt tgccagaatt cagataatgc ccgcttccca accatcagca 1403281 ttcctcacca agaagcattt cggaacggct tggactattt aattgccaaa gggcacaaaa 1403341 aaatagccat ctgtttggca agaaaaaaag gcatgaacag ccattttcga atcaaagcct 1403401 acaaagaggc attggaagag atcggcgagg catttcgtga agactgggta attgagaaag 1403461 cgattacaat caatgatggg aaggcgcttt ttcataaatg gaatacgtgg aaggaaaagc 1403521 cgacggctat ttttgttgcc aatgaccaag tctcagcagg gctttttctt gaagcaaaga 1403581 accagcgggt gtcagtaccg gatgagcttg caatcttaag cgttgataac cacgaaatca 1403641 gccaagcgct tggaatcaca acgatcgata ttcagacaag ggaaatggga aagcaggcat 1403701 ttgccatatt ggaaaaaaga attcaaggac agccgattga aaggaaagtt ctggattacc 1403761 gtctcatcga aagatcgact gtttagtgaa tgcattgaaa aaaggtttga cgtgcattct 1403821 gttcgttatg tacgatatga ggtattgaat gacaaaggag ctgaggatcg tgaatgggtc 1403881 cttcacagtg aaaaaggtac tgaataataa cgtattaatt gcttctcatc ataaatacag 1403941 cgaagtcgtt ttaatcggaa aaggtattgg tttcggaaaa aaacaagatg atgtcattga 1404001 agataaaggc tacgataaaa tgttcatttt aaaagacgag aaggaacaaa agcagtttaa 1404061 aaagctcctt gactatgttg atgaaaagct cgttgatatt tcaaacgatg tcatctatca 1404121 cataagcaat aggacgaatc actcattaaa tgaacatatt cacattgcgt tgacagacca 1404181 tatcgcattt gcgatcaaaa ggcagcagca gggatttgat atgaaaaatc catttctaat 1404241 ggagactcag tcactatatc ctgaggagta ccaaattgcc aaagaagtca tagatatgat 1404301 caatgaaaaa gcgggactct gccttccgga aggggagatt ggttttatcg ctctgcatat 1404361 ccattcagcg ttgacaaacc gtccgctgtc cgaggtcaat cagcactctc agctcatggc 1404421 gcagcttgtc gaggtgattg aagactcatt tcaaatgaaa gtaaataagg aaagtgtcaa 1404481 ctatttgcgg ctgatcaggc atatcagatt tacaatagaa agaattaaaa aagaagaacc 1404541 gactaaagaa ccagaaaaat taatgttgtt attgaaaaat gaatatccgc tatgctacaa 1404601 tacagcttgg aaattgatta aaatcttgca gcaaacattg aagaaaccag ttcatgaggc 1404661 ggaagcggtt tatctgacgc ttcatctgta ccgattaacc aataaaattt cataaattca 1404721 gtttatcctt ataacgtgtt actgattcga tcaggcatga gtgattgagg gaaaaaaacg 1404781 ggaagttcat tctcgttctt ttgcgcaccc aattttgctc atgccttttt gttgtgtaaa 1404841 agggcaaatg taaacggtta aactggaaga cttacgcctg tgaattcgtt gtcatgattt 1404901 ttagctgtaa ggtcagacta gtaaaaagag gaggtcaatt cttatgttta aagcattatt 1404961 cggcgttctt caaaaaattg ggcgtgcgct tatgcttcca gttgcgatcc ttccggctgc 1405021 gggtattttg cttgcgatcg ggaatgcgat gcaaaataag gacatgattc aggtcctgca 1405081 tttcttgagc aatgacaatg ttcagcttgt agcaggtgtg atggaaagtg ctgggcagat 1405141 tgttttcgat aaccttccgc ttcttttcgc agtaggtgta gccatcgggc ttgccaatgg 1405201 tgatggagtt gcagggattg cagcaattat cggttatctt gtaatgaatg tatccatgag 1405261 tgcggttctt cttgcaaacg gaaccattcc ttcggattca gttgaaagag ccaagttctt 1405321 tacggaaaac catcctgcat atgtaaacat gcttggtata cctaccttgg cgacaggggt 1405381 gttcggcggt attatcgtcg gtgtgttagc tgcattattg tttaacagat tttacacaat 1405441 tgaactgccg caataccttg gtttctttgc gggtaaacgt ttcgttccaa ttgttacgtc 1405501 aatttctgca ctgattctgg gtcttattat gttagtgatc tggcctccaa tccagcatgg 1405561 attgaatgcc ttttcaacag gattagtgga agcgaatcca acccttgctg catttatctt 1405621 cggggtgatt gaacgttcgc ttatcccatt cggattgcac catattttct attcaccgtt 1405681 ctggtatgaa ttcttcagct ataagagtgc agcaggagaa atcatccgcg gggatcagcg 1405741 tatctttatg gcgcagatta aagacggcgt acagttaacg gcaggtacgt tcatgacagg 1405801 taaatatcca tttatgatgt tcggtctgcc tgctgcggcg cttgccattt atcatgaagc 1405861 aaaaccgcaa aacaaaaaac tcgttgcagg tattatgggt tcagcggcct tgacatcttt 1405921 cttaacgggg atcacagagc cattggaatt ttctttctta ttcgttgctc cagtcctgtt 1405981 tgcgattcac tgtttgtttg cgggactttc attcatggtc atgcagctgt tgaatgttaa 1406041 gattggtatg acattctccg gcggtttaat tgactacttc ctattcggta ttttaccaaa 1406101 ccggacggca tggtggcttg tcatccctgt cggcttaggg ttagcggtca tttactactt 1406161 tggattccga tttgccatcc gcaaatttaa tctgaaaaca cctggacgcg aggatgctgc 1406221 ggaagaaaca gcagcacctg ggaaaacagg tgaagcagga gatcttcctt atgagattct 1406281 gcaggcaatg ggtgaccagg aaaacatcaa acaccttgat gcttgtatca ctcgtctgcg 1406341 tgtgactgta aacgatcaga aaaaggttga taaagaccgt ctgaaacagc ttggcgcttc 1406401 cggagtgctg gaagtcggca acaacattca ggctattttc ggaccgcgtt ctgacgggtt 1406461 aaaaacacaa atgcaagaca ttattgcggg acgcaagcct agacctgagc cgaaaacatc 1406521 tgctcaagag gaagtaggcc agcaggttga ggaagtgatt gcagaaccgc tgcaaaatga 1406581 aatcggcgag gaagttttcg tttctccgat taccggggaa attcacccaa ttacggatgt 1406641 tcctgaccaa gtcttctcag ggaaaatgat gggtgacggt tttgcgattc tcccttctga 1406701 aggaattgtc gtatcaccgg ttcgcggaaa aattctcaat gtgttcccga caaaacatgc 1406761 gatcggcctg caatccgacg gcggaagaga aattttaatc cactttggta ttgataccgt 1406821 cagcctgaag ggcgaaggat ttacgtcttt cgtatcagaa ggagaccgcg ttgagcctgg 1406881 acaaaaactt cttgaagttg atctggatgc agtcaaaccg aatgtaccat ctctcatgac 1406941 accgattgta tttacaaacc ttgctgaagg agaaacagtc agcattaaag caagcggttc 1407001 agtcaacaga gaacaagaag atattgtgaa gattgaaaaa taagggtgtt agtacgccgt 1407061 gcttgtcaga tgacaagtac ggttgtatga tataatattg tgaagtaata aagctttaag 1407121 ttaaaaggag aatgataaaa atggcacaaa aaacatttaa agtaactgca gattctggaa 1407181 tccatgctcg tcctgcgaca gttcttgtac aaactgctag caaatacgac gctgacgtta 1407241 atttagaata taacggcaaa acagttaacc ttaaatctat tatgggtgtt atgtctttag 1407301 gtatcgctaa aggcgctgag atcacaatct ctgcttccgg agctgacgaa aacgatgctc 1407361 ttaacgcttt agaagaaaca atgaaaagcg aaggactcgg cgagtaatgc aagaattaaa 1407421 agggattggt gcttcagccg gcatcgcgat tgcaaaagcg taccggcttg aagagccaga 1407481 tttaacggtt gaaaagaaaa acatctctga ttctgaagcg gaagtaagcc gttttgatga 1407541 agcgattgca cgttcaaaag aagagctcga aaaaatcaaa gagcacgctt tgaaagaact 1407601 gggtcaggat aaagctgata ttttttctgc tcacctttta gttctcagtg accctgagct 1407661 tctgaaccct gtgaaagaaa aaatcagcac tgattcagtg aacgctgaat tcgctttaaa 1407721 agaaacgtct tctatgttcg ttactatgtt tgaatctatg gacaacgaat atatgaaaga 1407781 gcgtgcggca gatatccgcg atgtaacaaa acgcgtaacc ggccacctgc ttggcgtcga 1407841 aattccaaac ccaagcatga tctcagaaga ggttattatt gtagctgaag acttaacacc 1407901 gtctgacaca gctcaattaa accgtgagtt cgtaaaagga ttcactactg atatcggcgg 1407961 acgcacatct cactctgcca tcatggcacg ttctcttgag attccagcag ttgttggaac 1408021 gaaagctgct acaggcacga tccaaaacgg cgtgactgtt atcgttgacg gtatcaatgg 1408081 cgatgtcatt attgacccat ctgcggaaac tgtaaaagag tatgaagaaa aacataatgc 1408141 ttatttggct caaaaagctg agtgggcgaa gcttgtcaat gaaccgactg tctcaaaaga 1408201 cggacatcat gtagagcttg cagcgaacat cggtactcct gatgatgtaa aaggtgttct 1408261 tgaaaacggc ggagaagcag ttggccttta ccgtacagaa ttcctttaca tgggaagaga 1408321 tcagctgcct acagaagatg agcagtttga tgcttacaaa acggttcttg agcgtatgga 1408381 aggaaaatca gtcgtcgtgc ggacacttga tatcggcgga gacaaagagc ttccttacct 1408441 gcagcttcct aaagaaatga acccgttcct gggatataga gcgattcgtc tttgccttga 1408501 agagcaagaa atcttcagaa cacagcttcg cgcgctgctt cgtgcaagta catacggaaa 1408561 cttgaaaatc atgttcccta tgattgcgac agttaacgaa ttcaaagaag caaaagcgat 1408621 ccttcttgaa gagaaagaaa agctcgtaaa agcgggacag gctgtatctg acgatattga 1408681 agtcggaatg atggttgaga ttccgtcaac tgcagtcatc gctgatcagt ttgctaaaga 1408741 ggttgatttc ttcagtatcg gaacaaacga tttgattcaa tacacaatgg cagctgaccg 1408801 tatgaatgaa cgtgtatctt acctgtatca gccatacaac ccggcaatcc ttcgcttaat 1408861 tacactggta attgaagcag cacacaaaga aggaaaatgg gttggcatgt gcggagaaat 1408921 ggcaggagac gagattgcga ttccgatcct tctcggctta ggcttagatg agttctcaat 1408981 gagcgcaacg tctatccttc cggcaagaac acaaatcagc aaattgtcta aacaagaagc 1409041 tgagtcattc aaagagaaaa tcttatctat gagcacgaca gaagaagttg tcgcgttcgt 1409101 aaaagaaaca ttcaagtaat gtacaaaaac cagacggcct ccggcctgtc tggttttttt 1409161 cataagtaag ggtatagaag gacacaataa catggctagg agggatagta tgtcaaacca 1409221 atttaacgca ggagatactg tttatgtgat ctacagaaat ccgcacgccg ccaatgtagc 1409281 ccacataaag gaagccgaaa ttgtgcacca tccataccat gaaggcgagc tttccctgtt 1409341 tatttatgaa acctatcatc cattcgcaga ggacgatgct gtgtttgcaa gctatgaaga 1409401 agctaaatcg ctttacaaag aactgtttga tattgatccg tatgagtaac aaggaaatca 1409461 ttacaactca tatcctttcc gcctagtgag aaaagtaacg ttagtaaagg aaaaggatgt 1409521 ggcatcatgc agaacccatt tgttccgcag cttgtgtata tagaaccgag ggcgctggaa 1409581 tatccgctgg gccaagaatt acaagataaa tttgagaata tgggtattga aatcagagaa 1409641 acgacatccc acaatcaggt gcgtaatatc cctgggaaaa atcatcttca gcaatatcgc 1409701 aatgcgaaat caactttagt tatcggtgtc cggaaaacat taaagtttga ttcatccaaa 1409761 ccctcggccg aatatgccat tccgtttgca acaggctgca tggggcattg tcattactgc 1409821 tacctgcaaa caaccatggg atcaaagccg tatatcagaa cttatgtaaa cgtcgaagag 1409881 attttagatc aggcagataa gtatatgaag gagcgcgcac cagagttcac aaggttcgaa 1409941 gcatcatgta cgtcagacat tgtaggaatt gatcatctga cacacacgct gaagcgcgcc 1410001 attgaacatt ttggccaaag tgatctcgga aagctccgat ttgtaacgaa atttcatcat 1410061 gtcgatcacc tattagacgc aaagcataac gggaaaacga gattcagatt cagtattaat 1410121 gccgactatg tgattaaaaa ctttgagccg ggaacttcac ctcttgataa gcggatagaa 1410181 gcggcagtaa aagttgcaaa agcaggctac ccgctaggct ttattgttgc tccgatttat 1410241 attcatgaag gctgggaaga aggatacaga catctgtttg aaaagctaga tgctgctttg 1410301 ccgcaggacg ttagacatga cattacgttt gaattaattc aacaccgttt tacaaaaccg 1410361 gccaaacgag tgatagagaa aaattatccg aagacgaagc tcgaattaga tgaagaaaag 1410421 cgccgttata aatggggccg ttacgggatc ggaaaatata tttatcagaa agatgaagag 1410481 catgcacttc gagaggcact tgaatcctat attgatacct ttttccctaa cgcaaaaatt 1410541 gaatatttca cttaaacggg ctgttgtgat caacagctcg cttttttata aaaaacattt 1410601 ttccattcca tcaaaacgcc gtaattcaat gattctttat cctccaaata attgctgact 1410661 acacgaatag gtgaacgccc gcaacggagg agaaaggaca gcacagggtc gtttttcctg 1410721 ccttccatca catcttcaac gtactgaaca gcgctgatct cgtgtgcgta tttataatac 1410781 aaaggaatgc ggccgccgcc gagaaggcgt tccagtcttt tatcaacagt cagctcatac 1410841 atcgtattca tcagccattt tccgattcca agctttcgat aatgaggaga aacagaaata 1410901 tccactacat ataaagtatt tccatgaggt tcatgatttt taatcgatcc gttgtcagtt 1410961 gcttgtgccc atgtatgatc aggagaatca ggctcaaatt gtacaataag agcagtcatg 1411021 gaaccgataa ttctgccatt gatgagcgcg cataaagcgc cttccggaaa ggttttgata 1411081 tggctggcaa gctggtcctc tgaccacagc aattcctggg gaaacggagg agggaaacat 1411141 tcttcttgaa gagaaatcag cctctcgatg tcagtctcag tgtagtttct aatggtcaga 1411201 gcctcaaatt ttctgccgtc atgcacatac atttgtttta gtatgatcat cactctcctt 1411261 atgttgtttc attataacga agattgaatt ttcagtaaat atattccgat tttcttataa 1411321 tttatttttt gattattcat ttttcaaacg aaagggccga tatagaaatt aggaggggat 1411381 tggtttgttt aaaaaacttc acatgaagat tgctgttttt gtttcgatta tgttaatcat 1411441 cacagttgtt ctcttaatgc tgtcttctta tttgacgcta aaaccgatga ttacagagga 1411501 tgggaaaaat acaactcaaa acgtgacgca gtcacttgaa caaaatattg aattgcaatt 1411561 aaagagttat gccatttcgt tatcaagatt ggctaatggg gaattaacgc atacatttgt 1411621 aacgaaacca agtaaagaag cttctcggct gtttcacgat gacattaagc aaatcaaaga 1411681 caacgatgat tatgttgcga tggcttacat aggcaccgca aaaaaagaaa tgtttacata 1411741 tccaaaagcg gatttcgctg aggattacga tccaacatca agaccatggt ataagcttgc 1411801 agctgaaacc ccggatcaag ttgtttggac ggaaccttat aaagatgtcg tgacaggaga 1411861 catgattgtt actgcatcga aagcgatctt agacaggcaa aaagtgatag gggttgccag 1411921 ctatgacttg aaactctctg ctatccagag tatggtcaat aaacaaaagg tgccttacaa 1411981 aggatttgcc tttttagctg atgcgagcgg caatctttta gcccatccgt caaatcaagg 1412041 aaaaaatata tcaaaggatc aaacactgca aaccatcgca tccgagaaaa aagggataca 1412101 agatgtgaat gggaaaatgg ttgtgtacca aacgattggc gagacaggct ggaaggtcgg 1412161 aacgcaattt gataccgatc aattaatgtg gatttcagat aaaatgaatc gggccaatct 1412221 ttggatatca ttgattgcgc ttatcataac aattattctc agctacttcc tggccaaaac 1412281 gataaccggt ccgatacagc agctgatcgt aaaaacgaaa gctgtttccg caggcgattt 1412341 aacagtgcgc gcggaatcaa aatctaagga tgaagtcggt attttaacaa gagatttcaa 1412401 tctgatggtt gaaaatatga aggaaatggt tgagcaagtg agactctctt cagggaaagt 1412461 atctgacacc tctgaacaac taacggctgt ggctgccgaa actaatgaaa caagcggaca 1412521 aattgcaaaa gcgattgaag aagtagccgc aggggcatcg gaacaggctt ctgaagttga 1412581 aaccattaat gaaaaatcgg aaagcctgtc aacgaaaatc aggcaaatcg ctgaggaggc 1412641 aggcggaatt aaagaacgct caaaatcgtc cgaggatgca agctataaag gacttgacgc 1412701 gctcggccag ctgctgatga aatcaaacga agccaatatg gaaacgaaaa aggttgaaac 1412761 gatgctgctg gatttggaaa atcaaactaa gaatattgaa gaagtcgtta cagcgatttc 1412821 aaacatatct gatcaaacca acttgcttgc cttaaatgcc agtattgagg cagccagagc 1412881 cggagaaagc gggcgcggtt ttgccgtcgt agccgatgaa gtgcggaagt tagctgagca 1412941 atcagccctt tctacaaagc atatcagcga gactgtgaag cttatccagc ttgagacaaa 1413001 agaggcctct cacgcgatgg ttgaggcaag cagaatgaat gatgaacaaa acagtgcaat 1413061 tcacgaaact ggagaggtat taaatacgat aactgcagaa atgcagtcac tggtacaagg 1413121 tattgatcac atttacgcgg aaattcaaag aatgagtgaa gaacagcttg cgatttctga 1413181 agccattcaa agcatttcag ccatatcaca ggaatcagct gccgcagcag aggaagtgaa 1413241 cgcatcaacc gatgaacagc ttgtcaccct tgataaagtc aaacactcaa cggaaacact 1413301 aaaacatgca agccaagagc ttatgaacac aattgcaaaa ttcacattgt aatccaatta 1413361 catccccaaa catcatttgt tttggggatt ttttatttta taagatgaat agatatggta 1413421 gtctagaaaa tgaaggaaaa atgataaatt ttaactaaaa tctaaacgaa acatctggga 1413481 ggaatgacct tgaaaaaaac aattggtttt atcggtcttg gagtaatggg aaaaagcatg 1413541 gcatcacata ttctcaatga cggccatcct gtattggtgt acacccggac aaaagaaaaa 1413601 gcagaaagca tacttcaaaa aggcgcgatc tggaaagata cggtcaaaga tctttcgaaa 1413661 gaagcggatg ttatcatcac aatggtcggc tatcccagtg atgttgaaga agtgtatttc 1413721 ggaagcaatg gaattattga aaacgcaaaa gaaggtgcat atcttattga tatgacgaca 1413781 tctaagcctt cgcttgcgaa gaagattgct gaagcggcca aagaaaaagc attgttcgct 1413841 ttagacgctc ctgtttccgg tggagacatc ggtgcacaaa acggaacact cgcgattatg 1413901 gtcggtggag aaaaagaagc ttttgaagcc tgcatgccga ttttctcttt aatgggagag 1413961 aatattcagt atcaaggacc ggctggaagc ggacagcata ccaagatgtg caatcagatt 1414021 gcaattgcag ccggtatgat cggtgttgct gaagcgatgg cttatgccca aaaatcaggc 1414081 ctagagccgg aaaatgttct gaaaagcatc acaacgggcg cagccggaag ctggtcattg 1414141 tcaaatcttg ctccccgtat gctgcaaggc aactttgaac cgggatttta tgtgaagcat 1414201 tttattaagg atatgggaat tgcactagag gaagcagaat taatggggga agaaatgcca 1414261 ggcttgtcgc tcgcaaaatc tttatatgac aagctagctg ctcaaggtga agaaaacagc 1414321 ggaacacaga gtatatataa gctttgggtg aaataaaaaa agattgcctg tacgaaacag 1414381 gcaatctttt tttattattt tccgatgaat tgttgtgtcc agatgcttcc agactcaacg 1414441 taaccaacac cgatgtgagt aaagttaggg tttagaatgt tttttctgtg tccttcactg 1414501 ttcatccaag cttttactac ttcttctggt gtcttttggc ccttcgcaat gttttcacct 1414561 gctgttttgt agctgattcc gaaagatttc atcatatcaa acggtgagcc gtatgttggg 1414621 ctttggtgat caaagtagtt tttgtctttc atatcctgag attttgcgcg tgcagatttg 1414681 cttaacgttt catcaatttg aagcggtttt aagccttgtt tttgtctttc tgcatttgta 1414741 agttcaacaa cttttttctc atatgcactt acagatgaag gtgcagacgt tgttgtgttt 1414801 gttttttcag cagttgcggg tgctttagaa gcagtgtttt gatcagcagc tgctttttca 1414861 gtagtctttt gtgcaggttt tgccgtttct gtcttttgaa catcctgaac tttcacgtta 1414921 gattgcttcg catgtttttg aagaagctgc ttcatctctt tttcgtttgc agcgtttaac 1414981 gttttgatat ttgtgttaat atgcagtttt ttcactgcat cgttaagtga catgttttgt 1415041 actgtgttcc ccgtttttac tgtaaccaca ggctggcagg agagttcttt cgctgatgct 1415101 tgctgtacgc ccccgaatgt gaataatcca accgcagcgg cagcagataa aataaatgct 1415161 ttcttcatta gttcgtaacc tcctagagtt gtttgtttct acagaaaaat cataacatag 1415221 cttttttgtc ataaagattc cagcactttc ctttgacaaa tagagattgt cattttcgta 1415281 aagtaaatcc gttgaatcac taagaataag ggaatcagcg gtatatatga ttttatcgta 1415341 ccgttacata gcttcctttt ttttgaaccg ttagttatat tttaatgtgt ttttatattg 1415401 acagcttttt ttactccttt tcgctgtaac aactattaca aaggtgttac aattaatctc 1415461 agtatatgta aatatattga atgatttgag aggggtaacc agaagtgact gaaataggac 1415521 gtgaaccaaa gaaaaagagc aaaggaaaca gagcaatcag aatgaacctt tttttcctag 1415581 ctgtctttgt tctattcact gcattaattt ttaagctcgg ggttgttcaa attgttgaag 1415641 gcgaacagca tgaagaagac gctgagaaat caaatgcaaa aacagcttac tatcctgcgc 1415701 ctcgcgggaa gatgtacgac agaaaccaga aagttgctgt cgacaaccag agcgttccag 1415761 aaattgtgta tgtatcaaca tctagcacaa aaacagaaga taaaatcaaa acagcgaagc 1415821 ggcttgcttc tttcattcat attgataccg aatttttgaa ggaaagggat cttcgtgatt 1415881 actggatcgc agctcatccg aaaaaagccg ccgctctgct taaggaatca gaaagcaatc 1415941 tgaaaggaga ccaggcttac aagcttcaaa tagagcgtgt tccggatcaa gaattaaagg 1416001 ctattcagca agatgacgaa gaaatggaaa ctgctgcgat atatacaagg ttttcaagcg 1416061 gaaatgctta cgaacctcaa atcgtaaagg caatgaatcc aaataagagc aatagcaatg 1416121 gaaaaaacgg agcgctgctt gatgagaaga aaaactcctc gcaaagacca aaaaatgact 1416181 taacatatga tgaaatttcc attgtttctg agcatttaga agaacttccg ggaatcgata 1416241 tcgtaaacga ttggacacga aaatatcctt atgacaaaac cctttattct gttttcgggg 1416301 gcgtcacgac acctgatcag ggcctgctga gcgaccggaa agatttctac ttaacaagag 1416361 gctatgcgaa taatgacagg gtgggaaaaa gttatttaga gtatcaatat gaagaatatt 1416421 taaattcgca taaagaaaaa gtggaatacg tagaagataa taaaggaaat gtcgtcagcc 1416481 aaaaaaccat tgataagggc agcaggggat acgatcttca gctttctttt gacatggagc 1416541 ttcaggcaaa ggtagaaaag atcattgaag aagaagtaag aaacagccgt gcacgcggaa 1416601 attacatgct tgacagagcc tttgccgtaa tgatggaccc gaataacggc gatattttat 1416661 caatggcagg gaaaaagata gatttaaaaa ccaacaaaat tgaagattat gcgatagggg 1416721 catttaccac ccaatatgaa atgggatcag cagtaaaggg ggccaccgtg ctagccggct 1416781 atcaggacgg gatcccgcat tataaatatt atatcgatgc tccaatgctt ttaggaacga 1416841 atcttataaa aaaatcttat actaatatgg gaaccatcaa tgaattaacc gcattgcaaa 1416901 aaagttcaaa cgtatatatg ttcaatgttg ccatgcatat tgcaggcgta acatacaagc 1416961 cgcatggatc tctcccggct gatcagaacg atctactgaa aatgagaaac tattacagcc 1417021 agtttggtct gggagtaaag acaggtattg atctcccgca ggaatcagcc ggaatgcaaa 1417081 ccacacctaa aactgtagga ggattaattt tagacttagc aattggccaa tacgatacat 1417141 acacaccgct tcaaatggct caatacatct cagtaatcgc caatggtggc tatcgtgttc 1417201 agcctagaat cgtcacaagt attcataagc caggaaaaaa agaccagctg ggtaaggcga 1417261 ttgaacatag gaaacctaaa gtactcaata agattaataa ttcagagagc gatttgaaac 1417321 aagtacaaac aggcatgaaa ttagtcactt cttcagggac agcaaaaaat acgtttacag 1417381 aagatgtatc agggaaaacg ggaacagcgg aaacatttta ctacggcacg aatcgcaact 1417441 ggtgggggaa aaaaacatac aatctgactt ttgtcggcta ttacccgtcg aaaaaaccaa 1417501 aagtggcctt tagtgttgtt gttccatcag tagatgatga tgataagatc aataaaatta 1417561 ttgccaaaag agctatccac gcctacgcag agctcgaaaa aaaacacagt aaaaaataaa 1417621 aaacagggtg cacaactaaa agattgtgtg ccctttcttt tattcaaaaa ttgacgttca 1417681 ccataagaat agaaggagaa tactcatttt ctagcgaatc atactaggta aaagtcaatc 1417741 tgtatatgtc gaaacacgat gatcatgcaa aggagggatt ctgtggaaca ggatacgcag 1417801 catgttaaac cacttcaaac aaaaaccgat attcatgcag tcttggcctc taatggacgc 1417861 atcatttata tatctgccaa ctccaaactg catttgggct atctccaagg agagatgatc 1417921 ggatcattcc tcaaaacgtt tctgcatgag gaagaccaat ttttggttga aagctatttt 1417981 tataatgaac atcatctgat gccgtgcacc tttcgtttta ttaaaaaaga tcatacgatt 1418041 gtgtgggtgg aggctgcggt agaaattgtt acgacaagag ctgagcggac agaacgggaa 1418101 atcattttga aaatgaaggt tcttgaagaa gaaacaggcc atcaatccct aaactgcgaa 1418161 aaacatgaaa tcgaacctgc aagcccggaa tcgactacat atataacgga tgattatgaa 1418221 cggttggttg aaaatctccc gagtccgcta tgcatcagtg tcaaaggcaa gatcgtctat 1418281 gtaaacagcg cgatgctttc aatgctggga gccaaaagca aggatgctat tattggtaaa 1418341 tcgtcctatg aatttattga agaagaatat catgatatcg tgaaaaacag gattatacga 1418401 atgcaaaaag gaatggaagt cggaatgatt gaacagacgt ggaaaaggct tgatggcaca 1418461 cctgttcatt tagaagtgaa agcatccccg accgtctaca aaaaccagca ggctgagctg 1418521 ctgctgctga tcgatatctc ttcaaggaaa aaattccaaa ccatcctgca aaaaagccgt 1418581 gaacgatatc agctgctgat tcaaaattcc attgatacca ttgcggtgat tcacaatgga 1418641 aaatgggtat ttatgaatga atcgggaatt tccctgtttg aagcggctac atatgaggat 1418701 ttaattggca aaaacatata cgatcagctg catccttgcg atcacgagga tgtaaaagag 1418761 agaatccaaa acattgccga gcaaaaaaca gaatctgaaa ttgtcaagca atcctggttc 1418821 acctttcaga acagggtcat ctatacggag atggtctgca ttccgacgac cttttttggt 1418881 gaagcggccg tccaggtcat tcttcgggac atctcagaga gaaaacaaac agaagaattg 1418941 atgctgaaat cggaaaaatt atcaatcgca gggcagctcg cggcgggaat cgcccatgag 1419001 atccgcaacc ctcttacagc gatcaaagga tttttacagc tgatgaaacc gacaatggaa 1419061 ggcaacgaac attactttga tattgtgttt tctgaactca gccgtatcga attaatactc 1419121 agtgaactgc tcatgctggc gaaacctcag caaaatgctg tcaaagaata tttgaacttg 1419181 aaaaaattaa ttggtgaggt ttcagccctg ttagaaacgc aggcgaattt aaatggcatt 1419241 tttatcagaa caagttatga aaaagacagc atttatataa acggggatca aaaccaatta 1419301 aagcaggtat tcattaattt aatcaaaaat gcagttgaat caatgcctga tgggggaaca 1419361 gtagacatta tcataaccga agatgagcat tctgttcatg ttactgtcaa agacgaaggg 1419421 gaaggtatac ctgaaaaggt actaaaccgg attggagagc catttttaac aacaaaagaa 1419481 aaaggtacgg ggcttggatt aatggtgaca tttaatatca ttgaaaacca tcagggagtt 1419541 atacatgtgg acagccatcc tgaaaaaggc acagcgttta aaatttcatt tccaaaaaaa 1419601 taaaaacaac ggcttaaacg ccgttgttta tcgtctgcat tgcttcacgt ttttttaata 1419661 caaataattc taaacggtct aggccttctc tcagcgtgtc cattgagcat gcaaaagaca 1419721 gccttacata tccttcacca tatgttgaga acgagctgcc cggcacgagt gccacgccag 1419781 cgtcttccaa aagagccata ctaaaatcaa atgaagtcat tccaaatgat ttaatagaag 1419841 ggaagatata aaacgcaccg gacggtttaa ctacgtcaag tcccatggaa acaagacggt 1419901 cataaacata gtccagacgt tttttgtatt gttctctcat aatcaatgca tcgtcaaagc 1419961 cgtttgtgac agcttcaagc gcggcttttt gagaaatgga tgaggcgcac gacacattgt 1420021 attgatgaac ctttaaaatg tgctttgcaa tgtctttcgg tgcaaataaa aatccaattc 1420081 tccaaccggt catgctgtgt gattttgaca acccgttaat gacaatcgtt tgatcccgca 1420141 aataggttgc gatggagtaa tgcggtctgt catatgttaa ttcactgtat atttcatcag 1420201 acaatacgaa gacatttctg ccttttaaga gagctgcgat gcttttcagt tcttcttcag 1420261 ataaagtcac gccggtaggg tttgacggat aaggaagcac gacacacttg gtgttgggtg 1420321 tcagagcatc ttcaatcagc cgggcggtaa gcttaaagcc gtgtgacgta gtatcaacaa 1420381 tgacaggctt ggccccgcac aaattgataa taggttcata gcccggataa ataggccctg 1420441 gcataatgac ttcatcaccg ggagataaaa tcgtccggaa tgcagcatca atggcttggc 1420501 ttgcgcctgt tgtgatgata atttcagatt cagcatcata gttgaaatcc gcttttttct 1420561 tcatataaag ctgcacagct tgtctcagct ccaggtagcc ggcattcgga gtatatgacg 1420621 tcacgttttc atcaatggct ttttttgcgg cagctttcac atgatgcggt gtgaaaaaat 1420681 caggctggcc gattgtaagt gaaatgacgt cttcgtgttg ggctacaaga ttcgagaatt 1420741 tgcgtattcc tgaaatttcg atctctcttg ctttcggatt cagcaaatgt tccataattc 1420801 atcaccttaa caaatataat gagtttatcc tattttacca ctagctgatc atttgtcacc 1420861 tttttaactg atatatttcg attgtatgcg ccttttttct aaacatacct ttcttttcag 1420921 aaaaaaagaa gacaaccagc gatttgattg tctttattgt atcatgttct attattgttt 1420981 atatgtgcca atttcattaa tagccataat caaaatgaag gtcttcgtgc caaatcagat 1421041 acggaggatg ctcttcttga aggtcagctg attctttctt catattcagg taagtttctt 1421101 cactgatatc ctctaaaaca gtcatttcgt tttctttaaa tattactaag gtacccatta 1421161 tttacaccct tctttggaaa aatccttgac tattttatca ctgttagttg gaaagtcaat 1421221 ggttattagg aaaaaagttt cttttttgag gaacgcggct tgttgccttc ggaattcgat 1421281 tttgaagagc tgccattcac tttttacaaa ttacgccgat atatacagta caatactgaa 1421341 tgcgaatagc gagggattga attgtcgtta caacaatacg aaattttatt ggattctggt 1421401 acaaatgaat tagaaattgt gaagtttggc gtgggtgaaa atgctttcgg aattaacgtc 1421461 atgaaggtaa gagaaattat tcagcctgtc gaggtgacat cagtgcctca ctcccatcag 1421521 catgtagaag gaatgattaa actcagagga gaaatcctcc ctgtgatcag tctcttctca 1421581 ttttttggag tagagcctga aggatcaaaa gatgagaaat atatcgtgac tgaatttaat 1421641 aaacggaaaa ttgtttttca tgtcggctct gtttctcaaa ttcacagagt atcctgggaa 1421701 gcgattgaaa agccgacatc gttaaatcaa ggaatggagc ggcaccttac cggtattatt 1421761 aagctcgaag acctgatgat ctttttgcct gactatgaaa aaattattta tgacattgaa 1421821 tcagattcag gtgttgacac gtataatatg cataccgagg gcttcgatga aagaagaact 1421881 gataaaaagc ttatcattgt agaggactca ccgcttttga tgcgcctctt gcaggatgaa 1421941 ttaaaagaag cagggtacaa caatatcgct tcgtttgaaa atggaaaaga ggcatatgaa 1422001 tacattatga accttgctga aaacgaaact gatttatcaa aacagattga tatgatcatc 1422061 actgatattg aaatgccaaa aatggacgga cacaggctca caaagctgct gaaggaaaat 1422121 ccgaaaagct cagatgtgcc ggttatgatt ttctcatcgt taattacgga tgatctgcgt 1422181 caccgcggcg aagttgtagg cgcagatgag caaatcagca agcctgagat cagtgatttg 1422241 attaaaaaag tggatacgta tgttattgaa taaataaaaa cagccgttgc cagaaagagg 1422301 cacggctgtt tttattttaa aagtaactct cgccaagttt tttaaagacc ggtttatggt 1422361 aagctggctg ctggcgattt ggcactagcg gcttttcttt catgccgaca tattcttgca 1422421 ataggtgttt cgcttttgtt aaagacattt gagctttagg atttcgatac gattgattaa 1422481 gtgtacctaa atgcggaaga tgttcgaagt cttctttagt tggaggcatg tgaaaatagt 1422541 agtctccgat tgagataagc acgtccgatt gctgttggct gaaccttgga ttttttgaaa 1422601 aatgaagccc tattttcttt cctttacctt ctttgacaag cttttgcaaa gcccgttttt 1422661 tcagcagata taggtattta gggttggggg cggtttttgc atggcggttc acagtgtaaa 1422721 ctgcttttga aagattttct acggttggct gcagatcttt cgtatatgca tggtcgtcca 1422781 ttatttctct cctttgctct tatcaatttc tatatgttta gattatactt ttttaaagtt 1422841 gaaatgcaaa tattgaatgt aaaaatgcgc ttttttctaa gaaaaaaagc gcatttttaa 1422901 cctgcattat acagatcttg ccttcttttt cggctgttct tgaaatgctt cctgaacatt 1422961 cacttccaca gcctgagcac tgtattttgg cagtgcaata aaataaaaaa taaaaacgag 1423021 caggataata acacccatgc cgtaataaag ataatcaatg tttgaaacaa acttagggaa 1423081 taacagcgcg actaagccga gtgtcaaaga ttgtgcaaac atcataaaag ggtcctgcat 1423141 gccgcttaca cgtcccatca gttttggatg aacaattttt ggcatccacc ctccgattgc 1423201 aatgttgatc ggtccgatac acattcccag tgcaaaagct gccgcgtaat acacccataa 1423261 aatattggtg tagccgagga cgaagatcag caaacctgca atgaaaatcg gtatcgacat 1423321 taaaaagtgc ggcttcactt ttttagagat gagcgtgccg attacgcttc ctgccagaag 1423381 cccaaacccg agtgcgatcg taaatacaga cgtatgccac tcataacggt caggcgccaa 1423441 tccatatttc attgtaaaca tcggcaatac ggcgaatcct ccattgacaa atccaaaaat 1423501 gaagaagcca aaaataagag atgccagcaa tttgtttttt aaaatataga ggatgccttc 1423561 tctaaagtca tttattgaat ccttaacaga agtctttctc cagctgaatg caccgtttgg 1423621 ctgtcgggct tcttttggaa tccggcagct gcggatcagc agcccggaaa tgataaagct 1423681 gacaaaatca agaataatgg cgccttcaat accgattgtg ttgtacataa acgcgcctat 1423741 gccgactcca aacaccataa aaatgctaaa aagcatctga ttaagccctg ccgctttcgc 1423801 ataatgctcc ttcggcagaa tggcttgtac caaactgttt tctgccggaa agaaaaactt 1423861 tgttacagcg cttctgataa ataagataca aaaaacaaga ggaatattgc cggtaaataa 1423921 agtgaaaaaa agcacgacag tcaggcctgc tctgatccaa tcacaatttt ctgccacctt 1423981 ttttctatca aaccggtccg cgacgactcc cacgatcaga aatacaaata tggtcggaag 1424041 agaatacatc agctccgcca aggtcgtata tgaaggctgg ctgctgaatc ggtccagcaa 1424101 aaaaaaagca aaggccatgt tgcctactgt cgtgcccatt tgagaagcga gtgctgcgaa 1424161 aaatagacga acaaaattac gatttttaaa tatatccata aaaacgctcc ttaccctaaa 1424221 ggtcccactt tatcatatta taaaccgcct gtttttgaaa caaataagaa aacattaccg 1424281 gttaatcgtg actctcgttc cgtttggcac aattgaagca agttcgatca cgtctttgtt 1424341 atgcatgcga atgcagcctt tagaaacagc cttaccaatc gaagcgggat tattcgtccc 1424401 atgtattccg tagtgctgct ttgaaaggct cagccaataa gcgccaaatg ggccgccggg 1424461 attgcgctgg cggttaataa tgtaaaactc gccagtaggc gtttgcgtta gtattttacc 1424521 aacggcgatg ggataggttt tcattacccg attatttagg gacagcgtaa gggtcttcgc 1424581 tccgattgag actgcgatat gatacggaat tgtataaggg tccggcagtc cggggatgac 1424641 tatggactgt cccgcggtga gccctgcctg cagtgacgga ttagcctgga gtaatgcagc 1424701 cgtgctgatt ctgaaatcag ccgcgatgct gttcagtgta tcaccttgct tcacctggta 1424761 cgtaagcagt ttcctcatcc tcctttttta cttataagta ttgatgagga gcccatcctg 1424821 ctacattaat ttgtgctttt taaggtgaag acagtgattt caggcttggc aagaaaccgc 1424881 aaaggcagcc tggtcatccc gaggcctcgg tttacgtaaa tatgagtgct gcccgtttga 1424941 tacattccct ctgtgtagac ttttccatat ggaggcgtaa taatcggtcc gtaaaaaggc 1425001 agctgaatct ggccgccgtg tgtatggccg gaaagctgaa ggttcacggg ataatctgtt 1425061 gttttcaagg ctgcatcagg ttcatggacg agaagaatgg aaaaaagtct gtcgctcagc 1425121 cttgaaaggg tgccttcata atctgggttt cccagcatta agtcatcaag cgaagcaatc 1425181 tcgattttgc tgccatctgc gagtgacaat gtttgatagc cattgcgata taccgtgaaa 1425241 cctccggccg tcatcaggct tttgtaaacg gcagttccat agcctccgtg atcatgattg 1425301 ccgtaaatac aaagcttgcc gaagggagca ttaagctttc tcaataatgg aatgactgcc 1425361 tggtggtgct ggtacgtatc aggattatca ataatatcac ctgtaaaaac aatgagatca 1425421 ggtttagatt cattaattgt aagaatgaca gtttttaaat cttcgagagt aaagtaatca 1425481 ctcaagtgtg catcgctgaa ctgcacgatt ttaaaaccgt caaatccgtg cgggatgaga 1425541 gagcttttta ttgtgtgttc ggttgtctcg atcatatgcg gctcgagata cctggcatag 1425601 ccatatcccc cgccggccgt taaagccccg gcagcaagag cgccgaacat tccttttaga 1425661 aattgtcttc tggacatctt tttcatttca aaccaacctt taatagagtt tttctattat 1425721 atcatctgta tctgataaaa atctcatatg agcatgtgct gacagaggca gggatataat 1425781 gatagaatat tattgaatga ataatcattc acaattggag ggataaacat ggaaaaaaag 1425841 gcggtaatta ttaccggcgg gtcaagcggc atgggaaaag cgatggcaaa aaaacaggct 1425901 gaattagggt ggcacgttat ggtgacaggg aggaaccatg aggcacttga ggaaacaaaa 1425961 aaagaaattc agacctttga gggacaggtc gcttgttttc aaatggatgt ccgttccgat 1426021 tccgccgctt cagacatgat taaagaagcg gtaaaagcct ttggccggct tgacgcgctg 1426081 attaacaacg cggccggaaa ctttatttgt ccggcagaaa agctgacgcc caatggatgg 1426141 aaagccgtta ttgagattgt tttaaacggc acattttttt gcagccaagc agcggcaagg 1426201 cattggattg accagaagca gcagggtgtc attttaaata tggcagccac gtacgcttgg 1426261 ggagcgggag cgggggtcgt tcattccgct gcagccaaag cgggggtatt gtcattgaca 1426321 agaacgctgg ccgttgaatg ggggagcaaa tacggcattc gtacaaacgc gatagccccc 1426381 ggaccgattg aacgaacagg cggtgcggag aagctatttg aatcggaaaa agcgatggcc 1426441 cgcacgatga acagtgtgcc gctcggccga ttgggcacac cggaggaaat cgccgctttg 1426501 gcagcgtttt tgctttctga tgaagcatcc tatataaacg gggattgtat cacaatggac 1426561 ggggggcaat ggctgaatcc ttatccgttt taatctgaat atttataagt gaatatttaa 1426621 gttattaaga acttttatgt tcgaatgtaa tacctccaca attaaccttc ttcctatcca 1426681 atttgataac acatagagct ttatttgttt atgaggtgtt gtgtcatacg taagccacct 1426741 aatatatgaa aggtatattt taaaagggga gacgaaatat gaagaactta gatttcaaat 1426801 aaaacattca tataattact tcgttaacta aaaagagaaa ttataagaat gaaaggtttc 1426861 aaggttacat cagattggga ggaaggtaat ataatggacg agatggtatt attaactcag 1426921 gaatggctca atgaaacgta caaaggaaaa agtggctaca attccattga ggaaaatggg 1426981 aaaactggct ggaaaacaat gtatgcatta actagagcat tacaactaga attgggaatt 1427041 acacagactt ccgacagttt tggtcctaca actttaagaa agcttaaaga attaggcccg 1427101 atttctacgt caactaattc aaaaaaaaat attgtgaaaa ttattcaagg tgctctttat 1427161 tgtaaaggtt atggtccagg tggattaacg ggtacatttg gtcagggaac gaaagaggcg 1427221 atagcagaaa tgcaattgca tatggggctt tctaaaacag acggtgtagt aacgcctaag 1427281 gtgtttaaag ctttattaaa catggactct tatatccttt taaatggggc gtcagagaaa 1427341 gttcgttcaa tacagcaatg gctaaataat aaatattaca atagagagaa tttctacttt 1427401 atgccctgtg atggcctgta ttcaagggat actcaaaagt ctcttgttta tgcaatacag 1427461 tacgaggaag ggttaagtga tagtatagct aatgggaatt ttggaccaac tactcaaaga 1427521 ttgattcctg tattaagaat tggagaaaca gatgaaaaaa acagttttat tcatttattt 1427581 caagctgctc taatctttaa tggctacaat gttccttttg atggagtata ctctgaatct 1427641 gtaagatcaa aagtaaaggc ttttcagtct tttgcaaaat tacaacagag tggtactgcc 1427701 gactttcaaa catgggcttc acttctagta agtactggag accccaatcg aaaaggagtt 1427761 gcttgtgact caattactca aattacatcg gacagggcgg agtcccttaa gagggcaggt 1427821 tataagattg tagggcggta tctaacaaat gcgccgggga gtacactaaa taaaaaaata 1427881 caaccaggtg aattagaaac tatcttaaaa tcaggtttaa atgtttttcc gatttatcaa 1427941 acctatgggg gagcaacaaa ttattttaat aaagaacaag gaaagaaaga tgcgtttgct 1428001 gcttataaag cagcaaaaga atacgggttt aaaaataaca ctgtaatata ctttgcagta 1428061 gattatgatg catatggtaa cgatttaaac aacaatatta ttccacactt cgaaggtata 1428121 aatgaaataa tgaacggttt tttaggttca acttacaaaa ttggtattta tgcccctagg 1428181 aatgtatgta ctatagtttc taaaaaaggt ttagcatttg caagttttgt aagtggtatg 1428241 tctactggct ttagcggaaa cttaggatat cctttgcctt acaattgggc gtttgaccaa 1428301 atttcaacaa ttactgttgg aaatggttct ggaatgattg aaattgataa tgatatttgt 1428361 tcaggtttgg ataatggagt taataccata aatatagtgc cttcagagaa taagaagttt 1428421 tttgatcaaa ttgatgtttt atatgaaact gctgaaaaat atgctcaaat gcaaagcgac 1428481 ttaaataatg gggtaaaaaa aacacaatta gctaatgagt tggttgccca gtatttaaga 1428541 aaggatgact acaaagggtg gaagtgggtc cctaccgcag gccagattga tcctatttat 1428601 cgtgaatggg cagtaaagcg ctaggggaag acctagtaaa tggaattgtt gatcctatat 1428661 caaaaactgt cataggaacg cagcatctta tggcaactta taatgccatt atttatagtg 1428721 gtggttactc tcaaacacta cgagattttg ctggttggac tggagatcta ttaacaacaa 1428781 tacaggacat gaaattacac gctcaagaat ttaattcgcc ttatgatgcg gctatgaaaa 1428841 taataggtaa tatgtatcaa tttagcctag atgatttatt tagtgatgta gatgcaatta 1428901 atctagcgaa taaaacatca gttggtgcta atgcacaacc tctaaatatc gcaattagag 1428961 attattatag taataatgac tgtatgaata ggttcactca atttgtaaat aatagatttg 1429021 atggttcgtt agacaaaatt ttctctgaag cagagtatta tttaaataca aaccttgacc 1429081 cagttgttgt tccaattagg ttagccttta aacgtgcttt tgatgttgag gattatagtg 1429141 aagagattgg aaaaataaca gcacaagcat ttagagatgt tatcgagaaa aaaatgatat 1429201 ctgaataaac tgcaaaacaa gcgaacgtta aaactggtcg ttcgcttgtt ttattttcta 1429261 tttaaattta tgatataatt tttaaagatt aaggagtgat tcattgaaga aattgttaaa 1429321 aaagttagtt gtattatttt taagcagttt agttatcatc tttaatgttt ggtactttat 1429381 tatttgtgct ttttccccag agtattatca aaatacaaat cttacttcta atgaaataat 1429441 aagatttgaa aaactatacc acatagattt tcctgatgaa acaaaattta ttaaagctag 1429501 agagtatttg gctgggcccg gaggagatac gtcagctgta ttatatgtgt ctctgccaac 1429561 caagcgggta gaaaaagttt tatctgatta cacgtatatg aaaataaact atactgacaa 1429621 tgtcggttca atgtatggag ttgacgtttc aaagagtgtc gccggtttaa caactcttac 1429681 atttggcact tacgataaaa aaggaacttt ctataatatg aaacatgatg atgattggat 1429741 gtataaaggc actgactgga atctttactt ttggacagct gctagttata atgctgttat 1429801 ttttgtattt gttttggtta ttgtgaaaca aatgaataaa attcttaatt aaccagtatg 1429861 tagattgata atctcaaaaa aattttcctc ttcttttaac atactccata cgacctactt 1429921 ttccatacta tgattttttt gaaatttgtg gtgtagttat aattgtgcgt ataatcagac 1429981 aaagatagag aagcaggtga taacatgttg gatccacttg atattttaac gaacattgat 1430041 gatgtccttc catattacca ggcgattttt agtgccgagg agcagaaggt tgtcggatat 1430101 gaggtgcttg gacgaatttt ggcagattca gaaatccaaa gtctcgggcc cttcttttta 1430161 gatgcgggga tacccgaaga atataaatta gaggttgata acagaattat ccgccaggct 1430221 cttgaccgct ttttagaggc ggattctgat ctgctgattt ttatgaatca ggatgccaat 1430281 ctgctgatgc tggatcatgg tgaaagcttt ctggagcttc tgaaagaata tgaagcgaag 1430341 ggaatcgaac tccaccgttt tgtgcttgaa attacagagc acaattttga aggggatatt 1430401 gagcagctct accatatgct tgcatactat cgtacatacg gaattaaaat cgcagttgac 1430461 aacatcggaa aagaaagcag caacttggac agaatcgcgc tgctctcacc agatctgtta 1430521 aaaatcgatt tgcaggcgct gaaagtgtca cagccgtcac cgtcatatga gcatgtgctg 1430581 tacagcatat ctttattagc aagaaaaatc ggtgcggcgc tgctgtatga agacattgag 1430641 gcgaacttcc agcttcagta cgcctggaga aacggaggcc gctattttca gggctattac 1430701 ttagtgtctc catctgaaac gtttctagag agagatgtat tgaaacaaag acttaaaact 1430761 gaatttcacc aatttatcac acatgagaaa aagaaactgg agaccgtcta tgagcactct 1430821 gaacagtttt acaaacgagt gcatcaggct gtgacctctt tgagaaaaaa caatctgtct 1430881 tctgatgatg actttattaa aaagctggcg gaagagctga cagattgcag cttcaggatt 1430941 tacatgtgtg atgaagaagg cgatcagctg acgggaaatg tgtttaagca agatggagaa 1431001 tggatttatc agccggaata tgcggaaaag aactggagct ggcgccctta ttttctggag 1431061 aacattatga gaatgagaaa tctcagaaaa ggttttttca gtgatctgta cagtgatttg 1431121 gaaacaggtg aaatgatcag aacgttttca tatccgatgg atgatcagat gtatttattt 1431181 atagacttgc cttattctta tttatatgag caggacggac tgatttaacg gctgaaaggc 1431241 cgtttttttt atgaaatgaa aaaaatatca aaaaacgatt gacattgata ctgagaatca 1431301 ttatcattta attatagaga gaagctactc tctgttcccc aacccctcta tcagatcaag 1431361 atccgaaaaa acttggcgct acccccgcca agttttttat ttgtcaaagc ataggacaat 1431421 ccaatgaaac aataaaccta actagtggta aacgtttaac acggggagaa acattgagtg 1431481 ccgaacaccc ctgacactgc tgcacgggtg aggaggaaaa ttcgttctga aatgattatt 1431541 tcagttccgt tgtttacctc tatccagcat gactcccatt gattatggcc acgcgggact 1431601 tcaccataaa attcaaaaga aggttttgac aaagttgcaa aaaggcattc ttaatgctgc 1431661 caaagattcg aaaaaaatta taattatgtg catgacattc aaaaaaagcc tcaaactaaa 1431721 gaaaaatagt ttttttcact ttttttcttt gcttaaattc agcagtgaaa atgccatcct 1431781 gtccgacttt atggtatgat gctcaataga acttgtatta taataaatac ttgttgattt 1431841 gaagttgctt tttgaaagga gtcttttttt agaatgtcac aattaatggg tatcatcaca 1431901 cggctgcaaa gtctgcaaga aacagcggaa gcggctaacg agccaatgca gcgttatttc 1431961 gaagtgaatg gtgagaaaat atgcagtgtt aaatatttcg aaaaaaatca aacgtttgaa 1432021 ctgacggttt tccaaaaggg tgaaaaacct aacacatatc cgtttgataa tatcgacatg 1432081 gtttccatcg aaatctttga acttcttcag taagattcct gaaatagggg gaacaagctt 1432141 ccgcctttgc aaaagtaatc gaaataaacg gtaaggaaca tacttgtttc atggttgtaa 1432201 atccttgaaa aggagtgtcg tgatggctga ttcttttctg ttttataatc tttcagaagc 1432261 acagatgacc tttcaagatg tgatggaacg gcttaaagcc tttgttcaaa aggacccccg 1432321 ttcttcttat gtgttatcga tcggaaccga ttcacaggtt taccgcgatt acacaaagtt 1432381 tattaccgca ttgcatttgc atcgtacagg caagggagct tggggctgct tgaaaaatca 1432441 tacagtcgac agacccatac atagccttcg ggagaagatt tcgttagaaa cggcgtacag 1432501 ccaagaaacg gccgctcata ttcttgatgg acacttaatg gatattaccg atctgctcct 1432561 gccctttacc ggtgaggggg cggatcttac ctttgaagtt cacttggata ttgggaaaaa 1432621 agggcttaca aaagatctga tccaagaaat gactggacgt attacctcca tggggattga 1432681 ggccaaaata aagccggatt catacactgc cttcagctat gcaaatcgtt tcacaaaata 1432741 atttggctga aaaagccaag gtaaatgtcg aattatgcgg ttgacgtttg ttatctgatt 1432801 acttattcta gcggtagagc tgaaagtaag ttgtcttgct ttcagaggta ttcagtataa 1432861 aacagggggc ctgattgcga atgagtctta tcggtgaacg atttacagaa gaagaacaaa 1432921 aacttctgct gaatatcctg atcaaccatg agtatgccat cgagctatta agcagtgaga 1432981 tcaacgatat agagacaggg accaaaaacg ttgacggaac cacctacaaa aaacttgtaa 1433041 cgctatacga ccgatttcga tttgaaaatt aatgggacac cctataattg atactccaca 1433101 aagagtatct tttttattga aaggaaactt ttcgacaaat actgataaag tttatattat 1433161 tgcaatatag ggaatgtatt gatgatgaaa atgaaaaggg gtcgaaaaca tgataagctt 1433221 acaatcagat caacttcttg aggcaacagt cggacaattt atgattgagg cggacaaagt 1433281 agcgcacgtg caagtcggaa ataaccttga gcatgcatta ttagtattga caaaaaccgg 1433341 atacacagcc atcccggttc tggatccttc ctaccgttta catggcttaa tcgggacaaa 1433401 tatgatcatg aacagtattt ttggacttga gcgaattgag tttgaaaagc ttgaccaaat 1433461 cactgttgag gaagtcatgc tgaccgacat tccgcgcctt catatcaatg atccgattat 1433521 gaagggattc ggcatggtca ttaataacgg atttgtctgt gttgaaaatg acgagcaggt 1433581 atttgaaggg atttttacga gaagagtcgt tttaaaggaa ttgaataagc atatacgctc 1433641 attgaataag taggctgtac ggtcctattt ttattatata ggcagagtga aaaaagaaag 1433701 cgcatacata atttaaacga gaatagggct tgaataagaa actaagattt tattagaatg 1433761 ggagataaga aaaacttatt gataacaaaa aggaggacga catgcagctt caagagcttc 1433821 atatgctcgt agttttagct gaggaattaa atatgagaaa ggcggcagaa cggctttttg 1433881 tatctcagcc ggctttatct cagcgcttac aaaccattga aaaggcgtgg ggaacaaaaa 1433941 tctttttaag atctcaaaaa ggattaacgg taacgcccgc cggtgagaaa atcattcagt 1434001 ttgcgaatga tgtgacatta gagcaggaaa gaataagaga aaatattgac gagcttgaag 1434061 gtgaaattca cggcacattg aagcttgccg tcgcctccat aatcggtcag cattggctcc 1434121 ctaaagtcct gaagacgtat gtggaaaagt atccgaatgc aaagatctcg ctcataaccg 1434181 ggtggagcag cgaaatgctg aaaagcttgt atgaggatca ggttcatatc ggcattataa 1434241 gaggcaaccc tgagtggaag gggcgcaaag attacttaat gacagatcat ctgtatttag 1434301 tggatactga aatttcctgc atcgaagata ttgcccatac agaacgtccg tttatccagt 1434361 ttaaaagtga cagcacttat tttcaggaaa ttcagcactg gtggcatcaa aaatttaaaa 1434421 cgtcgccgaa acagacgata ttggttgatc agattgaaac gtgcaaacag atggcgctgc 1434481 acggaatcgg ttatgccatt ttgccgtctg ttacccttca aaatgaagat aaagtgaata 1434541 aaatgcctct tttagacatg aaagggcatc cgatcggtcg ggatacatgg ttattaggtt 1434601 atgagcctgc ctttgaactg aaacaagttc aagcttttgt acaagtgata aaggatatgc 1434661 tggatcagga aaatccattt taaagacagc gaggtgctgt ctttttttta tttatctgtt 1434721 gacaatgaaa atcattatca tttaaagtga tacatatgat attgaaaatc attatcaact 1434781 aatggggtga taacatggct aaagccttga ttacatatgc cagcatgtca ggaaatacag 1434841 aagacattgc cttcataata aaagatacgc ttcaggaata tgagttggat atcgattgtg 1434901 tcgagataaa tgatatggat gcgtcttgtt taacctccta tgattatgta ctgattggca 1434961 cctatacatg gggggacggc gatttgccct acgaagcgga ggattttttc gaagaggtca 1435021 aacagattca gcttaatggt ttaaaaacag cctgcttcgg gtctggcgat tattcttatc 1435081 caaagttttg cgaagcggtg aatttgttca atgtcatgct gcaagaggcg ggagctgctg 1435141 tttaccagga aacactaaaa attgaattag cgcctgaaac agatgaagat gtggaaagct 1435201 gccgagcgtt tgcgagaggt tttcttgcat gggcagatta tatgaacaag gaaaaaatcc 1435261 atgtttcata aaggggcaac cgctgttacg gcatcggcgt tttctggata ttttgtggcg 1435321 gtacaaagag aaggcatttt tcattactct ttggagcagg gctggagaaa gctttttcgt 1435381 ttgaaaagta agatacactg tatcagctac atagggcctt acttatttgg cgttggtgaa 1435441 aagggaacag tcattcgttc ggctgatgaa gggaaaacct ggacgatgtc gagctttccg 1435501 acaaatgcaa cagtgtgggc gattaccggc agaaacaacg ggtttgtctg cgcccacggt 1435561 aagcattgta tttatgtatc ggatgatttt ggtgtctcat ggcgcgtagc caaacctttt 1435621 gccgaatttc ataatccccc tgttatccgg tcgttatgcc ttcacggggg caatctcttt 1435681 atcggcacgc aaatacacga atattttggc ggcatttggg cttacgacat taagcgtgac 1435741 actgtccaag ttgtcaaaaa agaaaaaaac cggatgacgg catccatgct cgtgttcaat 1435801 gaaaattggc tggtggcggc gatgggttct gtgaaaggaa agcacggtgc tgtcactgta 1435861 aggaatcttt tgaatggtga agaattcacc atacaatcca gtatgatcag aaatgaagaa 1435921 tcatttcttg atctttcaga ggatgatggc attatatatg tcactacaac acaagatgaa 1435981 aatggttttt cgagaattta ccaggttgat ctcgaagccc ggtcgttaaa atggttcgat 1436041 accattaagg gacatggatg gagagtggcc aatcagaaag agaatttctt ttgcgcaggc 1436101 ttgtatgaat gtaaatttgt ccagccgtac gaagtttcag caatgattca ttagaggagg 1436161 aacaaggaat tggcgaagat tttgctcgtt tatgcaacaa tgtcaggcaa cactgaagct 1436221 atggcagatt tgattgaaaa ggggcttcag gaggcgttag cagaagtaga ccgtttcgaa 1436281 gcaatggata ttgatgatgc ccagctgttt accgattatg accatgtcat aatgggaacc 1436341 tacacgtggg gagacggaga tctgcctgat gaatttttag atcttgttga agacatggag 1436401 gagattgatt tttccggcaa aacatgcgct gtattcggtt ccggtgatac agcatatgaa 1436461 tttttctgcg gagcggttga tacgctagag gcaaaaataa aagaacgcgg tggagacatt 1436521 gtgctgcctt cggtaaaaat cgaaaataat ccagaaggtg aagaagagga agaattaata 1436581 aacttcggga gacaattcgc aaagaaaagc gggtgcgctg tctgatcact cactgggaac 1436641 tgctaaaacg gctgttcctt tttttcttgt ctttgtatct ttcctttgat acagtaatga 1436701 ggtagaaaat caggaggagg actatacata tgaaaatgat ggacgcaaat gaaattattt 1436761 catttattca aaatagtaca aaatctacac ctgtaaaggt ttacgtgaaa ggtgagctgg 1436821 aaggaatcaa tttcggtgaa tctgcgaaag cttttatcaa tggaaacact ggtgtcgttt 1436881 tcggtgaatg gagcgaaatc caaacagcaa tcgaagaaaa ccaaagcaaa atcgaagact 1436941 atgtggttga aaatgaccgc cgcaattctg cgatcccaat gcttgatctt aaaaacatca 1437001 aagcgcgtat cgagccgggt gcgatcatcc gcgaccaagt tgaaatcggt gataacgcag 1437061 tcatcatgat gggtgcttct attaatatcg gttcagtcat cggcgaaggc acaatgattg 1437121 atatgaacgt tgtgcttggc ggacgagcta ctgttggaaa aaactgccat atcggcgcgg 1437181 gttctgtact tgcgggcgtt attgagccgc catccgctaa accggttgtg attgaagacg 1437241 acgtcgtaat cggcgcaaat gctgttgtgc ttgaaggtgt aacagtaggt aaaggagctg 1437301 ttgttgctgc gggagcgatc gtggtaaacg acgttgagcc atacactgtc gttgcaggca 1437361 caccagctaa aaaaatcaaa gacattgatg aaaaaacaaa aggcaaaact gaaatcaagc 1437421 aggaattacg ccagctgtaa ggaaaagttt gataaaaaag gcgtggataa tatatccacg 1437481 ccttattcgt ataggcagga ggaatagaaa tgaagataga ggagctcatc gcaattcgca 1437541 gagatctgca tcgtataccg gagcttggat ttcaggagtt caaaacccag cagtatttat 1437601 taaatgtctt ggaacaatat ccgcaagaca gaattgaaat tgagaaatgg cgaacagggc 1437661 tttttgtaaa agtgaacggg acggcgccgg aaaaaatgct ggcatacaga gcggatatcg 1437721 atgcgctttc tatagaagag caaactggtc ttccattcgc atcagagcat cacggcaaca 1437781 tgcacgcctg cggtcacgat ttgcatatga caattgcact cggcattatt gatcattttg 1437841 ttcaccaccc agtcaaacat gatttgcttt ttctgtttca gccggcagag gaagggcctg 1437901 gcggtgcgga accaatgctt gagagcgatg tattaaaaaa atggcagcct gatttcatca 1437961 ctgcccttca tattgctcca gagcttccgg taggcaccat tgcgacaaaa agcggccttc 1438021 tatttgcgaa tacatcagag ctagtcatcg atctggaagg caaaggggga catgcggcat 1438081 atccgcattt ggctgaggat atggttgtag cagcaagtac acttgtcacc cagctgcaaa 1438141 cgattatctc tagaaacaca gatccgctag acagtgctgt tattacagtt ggtaccatta 1438201 ccggaggctc ggcacaaaat atcattgcag aaacggccca cctggaaggc acgatccgca 1438261 cgctttctga agaatcgatg aaacaagtaa aggaacggat tgaagatgta gtgaaaggaa 1438321 tcgaaatcgg attccgctgc aaaggaaaag tgacatatcc gtctgtatat caccaagttt 1438381 acaatacgag cggattaaca gaagaattta tgtcttttgt tgctgaacat caactggcga 1438441 cagtaattga agcaaaagaa gcaatgactg gagaggattt tggctatatg ctgaaaaaat 1438501 atcccggatt catgttctgg ctcggcgctg attctgaaca tgggcttcat catgctaagc 1438561 tgaatcccga tgaaaatgcg atagaaacag cggttcatgt catgacaggt tatttttctg 1438621 tttatgccaa ttaagtacaa atgaaagaat aaaattccat aaaatgagca ctctagtaaa 1438681 cggaggtgtt caaaaatggc taaaaaaatt ggaattgaac aatcgttatc agatgtagaa 1438741 gctgctttaa aagaaaaagg atatgacgtt gtaatgatga aaagccctgc tgatgctcaa 1438801 ggctgtgact gctgtgtcgt aacaggtctt gataataatg tgcaagggat agccgatacg 1438861 gtaacacaag cacctgtcat tacagcttcc gggatgacgg ctgaagaaat ttgtagcgaa 1438921 gttgagagca gaattcagta ataaaaaaac cgaagcaaaa agcttcggtt cttttattta 1438981 ttctgtttct ttagggaaag cgcggtcgaa cgcgttcttt atttcttttc tcaacactcg 1439041 ttcgactcgc cactgttcca tattttctgt tttggcaatg accctgatta caatttcaga 1439101 agtccccagt tcttgaatcc cgatgacatt tgggccttct tttatttgtg gaagagccgc 1439161 tgccgtttca tcacaaacct gctgtaaaat atgaatcatt tcatcaatat ttctttcagc 1439221 cggcacttta atgtcaacaa gagcctgcat ggtaccacga gaatgattgc tcacgtttgt 1439281 gatgtttctg ttggggatgt aatgcagtgt tccgtcaaag ctgcggattt gagttgtcct 1439341 taagccaacc tgctcgacaa ttccgtcaaa ggtggaaacg gtaatataat ctccgacatc 1439401 caattgtttc tcaagcaaaa taaaaaaacc tgtcacgata tcactgacaa gcccttgggc 1439461 gccaaatccg acagccaggc cgacgattcc tgcccccgct aaaagagcgc ttggatcata 1439521 atgaaacaaa tctagaacca tgacgaaaaa tatgaaaatc aatgtataag caaatatgtt 1439581 aagagtcagg cttcggagcg tatgtgcacg tccgatagac aagctattct gctcctcgaa 1439641 ttttgcaaac agatgtttaa tgattttcat gcctaatgat cgaacgataa aatagagcaa 1439701 tatcataatg gcgagtttaa tgagcagaac accggcattt gtaatcagtc ccgcccaatc 1439761 atattgttta ataaagtcca tgttgagctc cttttctaat tgattgctgc acattgagac 1439821 tagttaccct gtacatgacc atgttaaacg ttttattcaa aaatgtcgaa gccaaagaca 1439881 tacatgattt gttaaaaatt gactcaggaa atctgctttt atataatggc attgcaatat 1439941 aactaaaaat ggttaatcac cctttatttt catgcgattt tgacctttaa gccaaacaat 1440001 aaattggagg gatacatatg gcagaacgta tggtaggtaa acaagctcct cgttttgaaa 1440061 tggaagcagt ccttgcaagc aaagaattcg gcaaagtaag tcttgaggaa aacatgaaaa 1440121 acgacaaatg gacagtgctg ttcttctatc caatggactt cacttttgtt tgtccgacag 1440181 aaattacagc aatgtctgac cgctatgacg agttcgaaga tcttgatgca gaagtcatcg 1440241 gggtttcaac tgataccatc catactcatt tagcttggat caatacagac cgcaaagaaa 1440301 acggtcttgg ccagctgaaa tacccgcttg ctgctgatac aaaccatgag gtatcccggg 1440361 aatatggcgt tttaatcgaa gaagaaggtg tggctttgcg cggattgttt attattaatc 1440421 ctgaagggga gcttcaatat caaactgttt tccataacaa cattgggcgt gatgttgatg 1440481 aaacgcttcg tgttctccag gcgctgcaaa ctggcggact ctgtccggct aactggaaac 1440541 caggccaaaa aacactttaa ttctttccaa gaacgaaaag cggtctagca tattcgttag 1440601 gcctctcttt taaaatagga gggaaaaagc aatgaaatta cgtcagccca tgccggaatt 1440661 gacgggagaa aaagcttggt taaatggtga agtgacgaga gagcaattga ttggggaaaa 1440721 gccgacgctt attcatttct ggtccatcag ctgccacttg tgcaaagaag cgatgccgca 1440781 agtgaatgaa tttcgtgata aatatcaaga tcagctgaat gttgtagctg tacacatgcc 1440841 ccgttccgaa gatgatcttg accctggtaa aattaaagaa acagctgctg aacacgatat 1440901 cactcagccg atttttgttg acagtgacca tgctttaacc gatgcatttg aaaatgaata 1440961 tgtacctgca tattatgtgt ttgataaaac aggacagctc cgtcacttcc aagccggcgg 1441021 gagcggtatg aaaatgcttg aaaaacgtgt gaaccgcgtt ctggctgaaa cggaataggt 1441081 atctgactaa atagtatttc ctaaaaacct gacctcatca ggttttttat ttgtgcaaaa 1441141 agcaatggaa gaagagtaag aagcttattt ttccaaattt gggtatagga attgatgatt 1441201 tgtttgattg atacgctaaa aaacacagct aatttttgat gtttttcctc aattttagat 1441261 aaatctcata tctcataact cgaaaattgt agatattaca ctaaatttct ttaaagaagt 1441321 aagtaaaata tatattttca acattatacc aaataaacta gaaagcccct taatcccttg 1441381 agaataaagg actcttttga aaaataaaac attttcagaa aataaggaat ttttcataga 1441441 gtaaatataa tagtaaaatg ctaaaataat agttgataaa attacttttg taatctaata 1441501 tcttaattaa agatgttaat tttgataggg ggtacattga ggaatgttta atgaaagaga 1441561 agctttgcgc ttgcggttag aacaattaaa tgaagctgaa gtgaaagtca ttcgtgaata 1441621 tcaaattgaa cgtgataaaa tatacgcaaa attaagagag ctggacagaa atggaagccc 1441681 ttccgaaatc aaaaaggatt tccgttctga aaaaaaacct gactctctgc cggttctcgc 1441741 tgagcttgcg gctcaggaaa tcagaagcta tcagccgcaa tcacagcagc agtctgttca 1441801 gcctcagctt caatctattt cctctcttcc tgccggtata ccagacggaa caacacgaag 1441861 aagaagagga acggcaagac cgggatcaaa agcagctaag ctgcgtgaag ctgctattaa 1441921 aacattaaaa cgccacaacg cggcgattaa gagctcggag cttcaaaaag agattgaaaa 1441981 agaaagcggt cttgaaatcc ctaatatgac aacgtttatg caaagcttaa ttaaaatgta 1442041 cccggaagtg aaaaagccat atcgcgggca gtacatttta gagggtgaaa tcgaatctgc 1442101 agaatcagca aacgaataaa tataaagaaa aactgcttgg catcgctcaa gcagtttttt 1442161 tattgaggtt ttttctgtga aggtttgttt tctttttcaa gattaagctt atacacccac 1442221 ttttgataag gcttttcttc agcggctctg tttttcagct cttcgattgt atggctcttg 1442281 gcctggtctg atgattgggc gtgggcaagc tgtttttgaa gcacatgtat ctgtttggtg 1442341 acatcttcaa ggatagtctc tacatgattt ggctgcgcgt aggccgctgg agcttcttct 1442401 tccgtttttt ctttttgttt cgtgccgcca tcaatatcgg caaaatgaga agcaatccag 1442461 gcatcgcttt catcaagttg ccgtttatac gatataatag tttcgtgaaa taatttttct 1442521 ttcgtttttt ctatgtctag cagtctttct ttcgtttcta tgattcgatc tttcatatga 1442581 tcaacttcta ttttaatatg ttttagctga tattcttttt ctaccatttg ctcttttaga 1442641 cgcccgtttt cggcttttat caattcggct tgctgttttg cctgaagcag tgcattttgt 1442701 tcctgctcaa ttgaggcttg aagttcgctg atccgtttat gaagattttt attttcttct 1442761 tcgattttga ctttcgcaat atgaagttta tgtttttctt cgatttcggc tctgcgttta 1442821 taggtttcag cagatagaag ctcctgcaaa acaacgattt tatcaagcag ttcagctctt 1442881 atttggtgca gggtttggct ggtgtgggag gcatgttttt cttttgttga catatgtgtt 1442941 aattcggcag acagctgctg gagtttttct ttcatatcgg tattttcttt gagcagtttg 1443001 ttatttttct gatgaaagta gcttgcttca agttcagaaa tcagcttatg gcaccttgaa 1443061 agctcggatt ttaaataaag gttctcctga gacacgtcgt ggaaaaaagg acctgatctt 1443121 ttcattcgaa ccatctccct catgatgtta acactacaat atgcaaatac tgaacagcta 1443181 ttcctcttta ataaacagac aagcagtagc gttgagcctt tgcttttgct atgcttttaa 1443241 cgaaactaga ggtgagatga tatgaagcat gtaaacgtac tgctggcagg gggagcctca 1443301 cgtcgctttg gagaaccgaa ggcgtttgtc aaatggaagg gcaggatgct ttacgaatgc 1443361 gctaaagagg cacttggaga acaaacggtt atcatcagcc gtcccgaatt tattgataga 1443421 tttcaagaaa acggtgaaaa tgaagtgtat caagatgctg agccatttca aggcatgggg 1443481 ccattggctg gtatatatac cgcttttaaa aagacagacg gtgatcttta tactgttctt 1443541 tcctgtgaca caccgctgat acaaagaagg acgatgctgg agctcaaacg tctgatgatt 1443601 gccggtgcgg acgcggtagt cccaatttca gacggacaag tgcagccatt gattgcgatt 1443661 taccacaaac gtatcatgcc agttctatac gatcagcttt ctgagaagag gttgagaata 1443721 tcagatttat taggcagaat ttcggtttgt tacgtacagg ctgaaaatat cggagcaaac 1443781 ccggcagagt ttatcaacat taatacacgt gatgatttta gctgtttgga agaaaaatcg 1443841 aactccctca agcgggactg acggggcaat aacatgataa gatgacataa aagataagga 1443901 gaacaggttt gatggaggaa cgttattcac ggcaaatcag atttaagcaa attggggaag 1443961 agggccagaa aagactggca gacagccatg tgctgattgt cggagcggga gcgctcggca 1444021 ctgcaggagc tgaagggctt tcgagagcgg gagtcggtac gattaccatt attgaccgtg 1444081 actatgtgga gtggagcaat cttcaaaggc agcagcttta tacagaaagc gatgccaaac 1444141 tccgcatgcc gaaagccatg gctgccaaag agcatctatc agcgattaac agcgagatac 1444201 atattgaggc gtatgttacc gaaggaacag ccgaaacgct tgagccgctg attgaaaaag 1444261 cagatgtcgt gatcgacgcg acagataatt ttgaaacccg catgctgata aacgatcttg 1444321 cccagaaaac aaagacacct tgggtctatg gcgcctgtgt aagcagccag ggaatgttca 1444381 tgactgtcat tcccggagaa accccttgtc tgtcttgttt gtttgagcaa attcctgtcg 1444441 gcggggcgac gtgtgatact gccggcatta ttccgcctgc tgtgcatatc gtttcagcat 1444501 atcagcaggc tgaggcatta aagctgttaa ccggccaaaa agaagcaata cagcgggggt 1444561 ttgtgacatt tgatgtctgg aacaattcgc atatgaagat taacgttaat catgtacgcc 1444621 gtgaggaatg cccatcttgc ggagctaatg cggtatatcc ttatcttcag gattggaaca 1444681 caccaaaagc tgctgtacta tgcggccgtg atacagtgca ggtaaggtca gaatcattaa 1444741 aaagaatccc gaaacaggag ctcattaagc ggctgaaaac aatcggcaag gtcgaggcta 1444801 atgcgttttt gctgcatatt ttttacgagg atttcagaat tgtcattttc aatgacggac 1444861 gggcactggt gcatggaaca aatgatgtga aagaagccaa ctccgtgttg gcaagagtga 1444921 ttggactgta acaacaggag gggtcagaat gctggagaaa agaacaccga taccggtaga 1444981 cgaggcagtt cggcgtgtct gccattttca aaaacaaggt gaaacagaat gggtggcgct 1445041 tgaagacagc cttcatcggt ttttagccga agatataact gcggatcacc acgtacctgc 1445101 gtttgaccgt tcgccatacg atggttttgc tgtcagagcg tgcgatacgg cagaagcttc 1445161 acgtgaaaac ccagttcggt ttgaagttat tgaccatatt ggagcgggag cagtatctga 1445221 aaaagaactt ggcccgtttc aggccgtgcg gattatgact ggcgcgcaaa tccctgaagg 1445281 ggcagatgca gtcgtcatga ttgaactgac tcaagccttt gaggagaatg ggaagtcatt 1445341 tatgtcttta aaacgccgct ttcagacggg ggataatatt tcaaaaacag gtgaggacgc 1445401 tcaaaaaggg agtgttttac tgacaaaggg cacccgggtg acaccaggag tgacggctct 1445461 tttggcaaca ttcggatacg catctgtgcc tgtcgtgaga aagcctgtag tcgggattat 1445521 cgcaaccggt accgaattgc tgaatgtcag tgatccgctg gaaccgggaa aaatccgcaa 1445581 cagcaatgcg agtatggtat atgcgcaagc gatagaagca ggcgcaacac cgctttattt 1445641 agggaaaatc tctgatgaac tggataaaag ctttgctgca gttaaagaag cgatgaaaaa 1445701 ggtggacttc ctgatcacaa ctggcggtgt gtcagtcggt gactttgact ttttgcctgc 1445761 gatctatgaa aaactcggag cggacgtgct gtttaataaa gttgccatgc gcccgggcag 1445821 cgtgacaacg gtggcgcatg caaacgatat gctgctgttt ggcctttcag gtaatccgtc 1445881 ggcatgctat gtcggttttg aactgtttgt caaaccgata atccagacat ggctgctcaa 1445941 tgaaacaccg cattcaattt gtgcggaagc tgttttgacc aaggattttc cgaagccgaa 1446001 cccatttacc cgatttgttc gtgcgctcgt gcaccatcag gaagggaagc tgttggcgac 1446061 acccgttggc ttagataagt cgagctctgt cacatcactt gcagatgcca atgcatttat 1446121 tatcctgccg ggcggtacgc gaggctacga atctggcaga acggttcaag tgctgctcat 1446181 cagagaagag aatggaagtg aatggccttg gtccgtcctt tcccgatcgt ccaagttgta 1446241 ggatttcaaa acagcgggaa aacaacgttt attgagcgca ttcttgaaaa agcctctgaa 1446301 cagggagtcc atttgggctg cctgaagcac catggtcacg gcggtgaacc gcaaacgctc 1446361 acggaaggaa aagacacgga ccgttacaag gcggcaggtg ctgatgtaac agcggtagaa 1446421 ggtgctggtg tgttacagct gactgcccgc cgcaattggg atttggcacg gctgattgag 1446481 ttataccaat ttctcgaaac agactgtctt ctgattgaag gctttaaaaa agccccttat 1446541 cctaaagtgg ttatcctaag tgaaaaggaa gatctggaag cgctgcaagc agtaaatata 1446601 atcgccatca tctatagaaa aaaagagcat atgacagagc atcagggatt acccgttttt 1446661 catgcggatg atccggttgc cgtggatttt gtgctttcac agctgaaggg ggaatctgca 1446721 taatggaacg gtttgagatt acgaaaacac ccattaatac tgaaaacatc atcaaaaaag 1446781 tggagaaacg ggaagcggga gccattacaa catttattgg tacggttcgg gaatggacaa 1446841 acggaaaaag aacggttcgg cttgaatatg aggcatatga accgatggcc gtgcaaatgc 1446901 ttgctcaaat cggcgctgaa atcgaagaaa aatgggaagg tgcctcagct gcgatcacgc 1446961 accgtatagg tgtgctcgat atcggtgaag cagcggtagt gattgctgta tcttctcccc 1447021 atcgaaaagc cgcatatgaa gccaatgagt atgcgattga acgcattaaa cagattgtgc 1447081 cgatttggaa aaaagaaatt tgggaagacg gtgagcaatg gatcggcgac cagctagaaa 1447141 cgacagctta tccgaacgga aaaccagacc taagcgaggg agagcagcat gattaaaatt 1447201 cttttatttg cagggcttgc tgaacaggcc ggtacacaag caatagaaat agatatggaa 1447261 caagcaacca cagatgaaat aaaagcgagt ctaaaagaac aatacggtct tgaatctatt 1447321 gatacggcta tgattgccgt taacgaaagc tatgtaaaag aaaatacctc tgtatcttcg 1447381 ggtgacacgg tagccatcat accgccggtc agcgggggat gaaaaccgga cggcatttca 1447441 gccgtccggt ttttctgtat ttcattggca tatccccaag tatcctcagc atacaatgat 1447501 tttctgtaag cgtttattct acatatgtta ctccctataa agtaagagac tcactccata 1447561 attagactga aattttgaaa aataatagaa atttatttcg ggtatcgata tagtgaagat 1447621 gataaatgtt ggaaaggtgc tggatatgga gacatttaaa agattaaaaa tgtattattg 1447681 gccgtacaga aaagtgttta tgtggtcgct tctagccatg cttttgatga ctgcaattac 1447741 tgtcgtttat ccgattatcc tgcaaattac gattgatgag atcgtactgg gacggcagta 1447801 tcagcttgcg gcgtgggtca gcttaggatt tattgcggtg atggttttga aaggaatggc 1447861 tacctttttt catcagtatt taggtgatat gttcgggatc aaatccgttt atcggctgag 1447921 aaatggtctg tatgaaaaac tgcagcggct ttctttttct tactatgata acgcgaaaac 1447981 aggagatttg atgtccaggc tgactgctga tgttgaaggg cttcgttttt tcttatcata 1448041 cggtctcgct gagctcattc gcttcggcct gctggtagcc atcagcctgt cggttatgtt 1448101 ttactattct gttcctctca cgcttgtgac aatagctgtt ctgccatttc tcgcggttgc 1448161 ggtataccgg tttgacaaaa gagtccatcc cgccttcaga ggcatccgca aatcgtttgc 1448221 gaaactcaat acaaaagttc aggaaaatat cagcggcatt aatacggtta aatctctttc 1448281 cagggaagat tttcagatca gcactttcaa taaagccaat gcagaataca gggcgcagta 1448341 tttacaaaca tcatccattt ggtctgcgta tttcccttta atggagttca ttggtaacac 1448401 ttgtattgta gctcttctct catacggcgg ttacttggtt atgcaaaatc agctcaatcc 1448461 cggcgagctt gttgctttct tcagccttgt caattatatg atgtggccca ttatgaactt 1448521 aggttttgtc atcaatatgt tctctcaagc aaaagcgtca ggggaacgcc tgctcgacat 1448581 tctggaaaaa gaagaagaca ttacagatca tcctcatgct ttgcataaac aaaaattaac 1448641 cggagatgtc catttcaaaa atgtttctct tgcatacgga aaagaacaaa caaacgcgct 1448701 gtgcaatgta agctttgagg caaacagcgg gaaggtaatc ggactgttgg gcccgacagg 1448761 ttcaggcaaa agctcagtga cacagcttct caccagattt tacagtcctg ttggcggaat 1448821 gattaccatt gatcacaaac ccatcacaga ttattcgtta aaaacccttc gctccaatat 1448881 cggggtcgta cttcaagaat ccttcctgtt ttcatctacg attagatcaa atatttcgta 1448941 tgggcggccg gatgcctcaa tggaagacgt catcgaagcg gcaaaaaggg cgcaggctca 1449001 taactttatt atggagcttc ctgatgggta tgacaccatg ctgggagaga ggggaatggg 1449061 gctttccggc gggcagaaac agcgtattgc cattgcgaga gccatctgct tgaacccgag 1449121 cattttaata ttggatgatg ccacaagcgc agtagatatg caaacggagc acagcataca 1449181 gcttgcctta aaagaagtca tgaaaaaccg cacaaccttt atcgtcgctc accgcatttc 1449241 ttcactgaaa cacgctgatg aaattctcgt ttttaataaa ggacgcattc gtgaaagggg 1449301 aacacatcat gagcttcttg aaaaaggcgg ctactataaa aagatttacg atttgcaata 1449361 ccgtgatgtc aaaatgatta atgagccgca tgaggtcgga tagggagggg ccaaatgaaa 1449421 caagcgaaaa aacagggggt tttagagcgt ttctattact cttcagatga aatcattgaa 1449481 aagccgttta actgggctca aatgtggcgg ctgctgagct atgtcaaacc atatcgaaaa 1449541 acaattttgc cgctttcttt tctcactgta ttgattggca ctgctgtgaa gcttgtgatc 1449601 cccattttga tcggcgttta tgttcttgat caagcgatta cagggagaaa ctcggagctg 1449661 ctgattcagc tcatttttat tattagcggt ttatatgtcc tcaattacgc cgccaatgtg 1449721 ttaagaatca ggtggatgaa tcagcttggc cagcatgtca tttacgattt gcgacagcat 1449781 ttatttaccc atgtgcagcg cttatcccat cgattttttg atcagcggtc ggcgggatcg 1449841 atcttagtca ggatcatgaa tgatattaac tctcttcagg agctctttac aagcggagtc 1449901 atcaatttgt tgaccgactt gctgcttctg gccggcgtga ttattatttt gtttacgctg 1449961 agccctgagc tgactatagc catcatggtg acattgccga ttatgttttt tatttcaaca 1450021 agtctcagaa aaaaaatacg ccgatcctgg caaacggtac ggctgaagca atcgaagctc 1450081 aactctcatc taaacgaaag cattcagggc atccgggtca cgcaggcatt tacgcaggaa 1450141 gaagaaaaca tggcgtattt tgacggtgtc aatcaggaga actacgaatc atggcgggaa 1450201 gcaactagaa aaaatgccat gttccgtccg cttgtagaaa tgacgaatgc gattgggacg 1450261 gctgtcttga tttggtatgg agccacactc atcatgaatg aaaccattac gattggcgtc 1450321 ttcgtttctt ttgctttcta tctgggaatg ttttgggaac ctatttcgag actgggtcag 1450381 gtctataatc agctgttaat ggggatggca tcatcagaac ggatttttga gtttctggac 1450441 gaacagccaa atgtcaagga gaagccgaat gccattcata atgaaaagat aaatggggag 1450501 atcagttttg aagaggttga attttcgtat gatgaaaaac gaaaagccct tcacgccgtt 1450561 tctttctcta ttcctgcggg atcgacgctt gcgcttgtcg ggcatacagg gagcgggaag 1450621 acgacgattg ccaatttaat cagccgtttt tatgatgcgg ccggaggcac cattaaaata 1450681 gacggtatac cgattaagga tctttccctt gccagtctgc gctctcaaat cagcattgtc 1450741 ctgcaagata catttatttt ctccgggacc atcatggaaa atattcgttt tggaaggcca 1450801 aatgcttcgg atgaagaggt gatgaaagcg tcccaagcgg tcggagcgga tgagtttatt 1450861 tccgatttag cggaaggata cgcaacagag gtagaggaaa ggggcagcgt actgtctgcc 1450921 ggtcagcgcc agctcatttc atttgcaaga gcattgctcg ccgatccggc tattatcatc 1450981 cttgacgaag caacggcaag cattgataca gagacagaag taaaaattca gcaagcgtta 1451041 aaaacgcttc tgaaagggcg tacagcagtg atgatcgctc acagattgtc tacgatccgc 1451101 gacgccgacc gcatcattgt tcttgatcac ggcaggaaaa tagaagaagg gaaccatgat 1451161 cagctgctcg ctaaaggagg catttatgcc gggcttgtga aagcgcaata cagcacagcg 1451221 atagaataat atgaaaagcc ttcaatattg aaggtttttg gaaatttatt agaaaaacat 1451281 gaaacttttt gatatccttc ccgtactatt tgttagatat tctcaaggag gttttgaaat 1451341 ggaaacgaat gtagaaaaaa acagcggaac ggcgactgaa aagccttcac ttttcggagt 1451401 aatcacaagt ccgtccgttc aatttgaaag aataagagaa aggccggctg tatggggacc 1451461 gcttttgatt gttgcagcaa ttatcatcgt cggtgccgtg ctgcaatcac tcggtacgga 1451521 ttatagtgag cttttgaaaa gccaggatac gcaagggcta tctgctgaac aaatggaaac 1451581 tgtcgcaaca ataaccaaat ttggcggaat ggcaggcgct attatcggcg gtatcgcagc 1451641 attatttatt gcccctctta tttattggct ctgtgtaaaa gtatcaggcg gtgttacgac 1451701 atataaaaaa atgctttctc tcagtctgtt tgtctctttg attagcagtc tcggattatt 1451761 ggttaatgga atcgttgctt ttacgactga cgtgaatcct ctttacagca cgacgtcact 1451821 cgcagggatt atcccatctg acggggctct cgccagtgtg ttaaatacct ttgaaatttt 1451881 cagcatctgg agctttgtat tattagcaat cggacttcac aaaacgggag gcatctcaaa 1451941 aaaagccggg tggatttcag caatcattct attcggaatt ttagttgtat tttcgctttt 1452001 ttcaggttta atcaattctg tggcgggtgc ataagctcat gaaaaaagtc tggatcggaa 1452061 ttggaatcgc agttatagtc gctctttttg ttggaatcaa tatataccgg tctgccgctc 1452121 cgacaagcgg cagcgccggc aaggaggtac agacggggag cgttgaagaa aatgaaatct 1452181 catcaacggt tatggttcct ggcacgctaa aattttcaaa tgaacagtat gtcttttatg 1452241 aagcggataa agggacatta gaagacatta aagtaaagga aggcgataaa gttaaaaagg 1452301 gcacggcttt agtcacctat acaaatgagc agctgagcct ggaaaaagaa cagaaccagt 1452361 taacgtctga atccaaccgg cttcaaattg accaaattca agaaaagtta aaagccttgg 1452421 acagcaaaga aagagaactg gaaaaacagg taggaaagaa agaagcagaa aaacaaatcg 1452481 aatctgaacg gacagagctt caaatgcaga aaaaaacagc ggagatcgaa ttaaaacaaa 1452541 ccgagcttca gcggcagtca cttgccaacc gggtgtcaga tttagaagtg aaaagcgaaa 1452601 ttgaaggcac cgttatttct gtcaaccaag aagcggcatc caaaaagtca gatattcaag 1452661 agcctgtcat acatatcggc aacccaaaag accttgtcgt ctcagggaaa ttgtctgaat 1452721 acgatacatt gaaagtcaaa aaaggccaga aggtcacact cacttcagat gtaatacagg 1452781 gtaaaacatg gaaaggcacg gtttccgcag tcgggcttgt tccggatcag caggagagcg 1452841 ctgcggcaca aggaacagaa caggcggtcc aatacccgct tcaagtgaaa ataaaaggaa 1452901 atcttccaga aggaaagcca ggctttaaat ttatcatgaa tattgaaaca gataaacgga 1452961 aagcaaatac gcttccttca aaggcagtca aaaaagaaga tgaccaatat tatgtgtata 1453021 cagtaaaaga cggaaaagca aagcgagttg atgtcaaaat cggcgaagtg acagatgacc 1453081 tgacagaaat taaagagggg cttacccaag atgatcaagt cattttgaat ccatctgatc 1453141 aggtgactga cggaatggaa gtgaaatcct aaatgattca gctttctaat gtgcgaaaaa 1453201 gctaccagat cggaaaggaa acgtttgatg ttctccattc tattgatttg gacattcatc 1453261 aaggtgaata tgtctcgatt atggggccgt caggatcagg aaaatcgacg atcatgaata 1453321 ttatcggctg tcttgatcgg ccgacttccg gtacatatca attggacggc gaagacattt 1453381 cttcatataa agataaagaa ctggcggcag tccgtaaccg gtccatcggt tttgtatttc 1453441 agcaatttca gcttcttccg cggctgaacg caaaaaaaaa tgtcgagctg ccgatgattt 1453501 attccgggat aggcaaaaag gaacgtcaag agcgggctga gagagcattg gaaaaggtcg 1453561 ggttagccga tcgaatgctc cacatgccca acgagctgtc gggcgggcag aagcagcggg 1453621 tggcgattgc gagggcgatc gtgaatgagc cgaaattgat tttagctgat gaaccgaccg 1453681 gcgcgctgga tacgaaaaca agcgaggcga ttatggatca gtttacagca ttaaatgccg 1453741 agggaacgac aatcgttctg gttactcacg agcctgaagt agcagattgc acgaatcgga 1453801 tcgtcatggt gcgtgacgga aacattgttc ctgccagctc cggacaaagg agtgtgggag 1453861 aatgagcctg ttggaaaaca tcagaatggc tctaagctct gtccttgccc ataaaatgcg 1453921 ttcgatctta acgatgctcg gcattatcat tggtgtaggc tctgtcattg ttgtcgttgc 1453981 ggtaggacag ggcggcgagc aaatgctgaa gcagtcgatc agcggcccgg gaaatactgt 1454041 ggagctgtac tatatgccta gcgacgagga gcttgcaagc aacccgaatg ccgcagctga 1454101 atctacgttt acagaaaacg atattaaagg tttaaaagga atagaaggca ttaaacaagt 1454161 cgttgcttcg acttctgaaa gtatgaaagc gcgttatcac gaagaagaaa ccgatgctac 1454221 ggttaacgga ataaatgatg gatacatgaa tgtcaattct ttgaaaatcg aaagcggcag 1454281 aacctttacc gacaatgact ttctcgcggg gaatagagtc ggaatcatct ctcaaaaaat 1454341 ggctaaagag ctgtttgata aaacctcccc tctaggtgaa gttgtctgga ttaacggaca 1454401 gcccgttgaa attatcggcg tgctgaaaaa agtaacaggc ttgctttctt tcgatttaag 1454461 tgaaatgtat gtgccattta atatgatgaa atcctctttt ggcacaagtg atttcagtaa 1454521 cgtatcattg caggtcgaat cagcagacga cataaaatcg gctggaaaag aagcggcaca 1454581 gctggtaaat gacaatcatg gcacagagga ttcgtatcaa gtgatgaaca tggaagagat 1454641 tgcggccgga attggcaaag taactgcaat tatgacgacg attatcggct caattgcagg 1454701 tatttccctt ttggtcggcg gaatcggtgt catgaatatt atgctcgtat cagtcacaga 1454761 acggacgcgg gaaatcggaa tcagaaaatc acttggtgcg acgaggggac agattctgac 1454821 tcagttttta attgaatcag tcgtattgac gctgattggc ggtctggtcg ggattggtat 1454881 tggatacgga ggggccgcgc ttgtttcagc cattgcgggc tggccgtcac tcatatcctg 1454941 gcaggttgta tgcgggggcg tgctgttcag tatgctcatt ggtgttattt tcggcatgct 1455001 tcctgcaaat aaagccgcaa agcttgatcc cattgaagcg ctgcgttatg agtagcctca 1455061 tgcaacatgc atgaggtttt tttatgttta gtgatttcta ctatgaatat aaaagacttt 1455121 tttcattaaa ataagaagaa aatgtcgtac aattgtcctt atttttgtcg aatttacagt 1455181 ttacaaaccc tatagacata cgttaatatg gagaaacgtg aaagattttg atagttattg 1455241 aatgaatttg aatgatttta gttgcctaaa ccgaaaatag cgtttacaat gaaattgtat 1455301 tcaaaatgaa tacgttttca ttaggaggtg aagcatgcta actcctgaac ggcatcaatt 1455361 gattattgat caaatagaaa agcatgatgt ggtaaagatt caagagctta taaatctgac 1455421 taatgcttct gaatcaacaa tcagaagaga tttatcgacc cttgaagaac gcggtttttt 1455481 aaagcgcgtt catggtggag cggccaagct ttccgatatc agacttgaac ccgatatgct 1455541 tgaaaaatca tccaaaaacc ttcacgataa actgaagatt gctgaaaaag ctgcttctct 1455601 tttagaagaa ggggattgca tttaccttga tgcaggcacg acgacattgc acatgattga 1455661 ttttatggat aaaaccaaag atattgtcgt tgtcacaaac ggggtaatgc atatcgatgc 1455721 attaataagg aaagaaattt ctttttatct gcttggagga tacgtaaagc acagaacggg 1455781 cgcgattatt ggaggcgctt cattggttgc catggaccag tacagatttg acaagagttt 1455841 tctggggaca aacggtgtcc atacagaggc tggatttaca acgccggacc ctgatgaggc 1455901 ccttttaaaa cagaaagcga tcaaacaggc aaaacacgct tacgtcttag cagacccttc 1455961 gaagttcgga gaaatttcat tttcggcatt cgccggaata ggcgacgcaa caatcattac 1456021 gactgacgct gaagagctta cattcgataa ttaccaagaa aaaactgtcg taaaggtagt 1456081 gaaaccatga tttacactgt aacacttaat ccatctgtcg attatatagt tcacgttgaa 1456141 gattttactg taggaggcct gaaccgttct tcgtatgata ccaagtatcc agggggcaaa 1456201 ggcatcaacg tatcgagact gctgaaaaga caccatgtgg cgtctaaagc gctcggattc 1456261 gtcggcggat ttaccggaga atatatcaaa acatttttac gggaagaaaa cctggaaaca 1456321 gctttttctg aagtaaaagg ggatacccgt atcaatgtaa agctgaaaac gggtgatgaa 1456381 actgaaatta acgggcaggg accgacaatt tcggatgaag atttcaaagc ctttttagaa 1456441 cagttccaat ctttgcaaga gggagatatc gttgttcttg caggaagcat tccatcttca 1456501 ctccctcacg atacttatga aaaaatcgca gaggcctgca aacagcagaa cgcacgagtt 1456561 gttctggata tctcaggcga ggctcttttg aaagcaacag aaatgaaacc atttttgatg 1456621 aagccaaatc atcatgagct tggagaaatg ttcggcacgg ccattacatc tgttgaggaa 1456681 gccgttcctt atgggaaaaa gcttgtagaa caaggcgctg aacatgtaat cgtatcaatg 1456741 gccggagacg gagcgcttct gtttacgaac gaagctgttt attttgctaa cgtgccaaag 1456801 gggaaattgg taaactcagt cggagcaggg gattccgttg ttgcaggttt ccttgccgga 1456861 atttccaaac agctgccgct tgaagaagca ttccgcttag gagttacttc aggcagtgct 1456921 accgcgttct ctgaagaact tggaacagaa gaatttgtcc agcagcttct tcctgaagtt 1456981 aaggtcacac gtctatagag gaggaaacac aagtgaaaat aactgagctt ttaacgaagc 1457041 atacgataaa gcttaatatt gagagcaaag aaaaagaaaa tgttattgac gaaatggtca 1457101 ctgttcttga taaggctgga aagttaaatg accgacaagc ctataaagaa gccattttaa 1457161 atcgcgaaag ccaaagctcc acgggtatcg gtgaaggaat cgctatcccc catgcgaaaa 1457221 cggcaagcgt tatcaacccg gcgatcgcgt tcggacgttc aaaagacggc gtcgattatg 1457281 aatcattaga cggccagccg gctcacttag tgttcatgat cgcggcgact gaaggcgcaa 1457341 acaacactca ccttgaagca ttgtcaagac tttcaacgct gttaatgcgt gaagaaatcc 1457401 gtaagcagct ccttgaagct gagtctgaag atgccatcat cgacattatt aatcagcacg 1457461 ataaagatga tgacgaagag gaagaggaag aagaagcggc accagcacct gccggaaaag 1457521 ggaaaatttt agcggttact gcatgcccga caggtattgc ccatacattc atggctgcgg 1457581 atgcccttaa agaaaaagcg aaagagcttg gtgtggaaat taaggtcgaa acaaatgggt 1457641 caagcggcat taagcacaag ctcactgccc aagaaatcga agatgcacct gcaatcattg 1457701 tcgcagcgga caagcaggtt gaaatggaac gttttaaagg caagcgcgta cttcaagttc 1457761 ctgtaacggc gggtatcaga cgtccgcaag agcttatcga aaaagcgatg aatcaagatg 1457821 cgccgattta tcaaggcagc ggcggcggtt cagcagcttc aaatgatgat gaagaagcga 1457881 aaggcaagtc tggaagcggt atcggaaaca cgttttataa gcacctgatg agcggtgtca 1457941 gcaacatgct tccgttcgta gtcggcggcg gtattctcgt tgcgatttca ttcttctggg 1458001 gaattcactc tgctgatccg aatgatccta gctacaacac gtttgcagca gcattaaact 1458061 ttatcggcgg cgacaatgca ttaaaactca ttgttgcagt tctggccggt ttcattgcga 1458121 tgagtattgc agatcgtcct ggttttgcgc ctggtatggt cggcggattt atggcaactc 1458181 aagcgaatgc tggattctta ggcggcttaa ttgccggatt ccttgccggt tatgtcgtga 1458241 ttttactgaa aaaagtattt acgtttatcc ctcagtcact tgatggatta aaacctgttt 1458301 tgatttaccc gctgttcggt atttttatca ctggcgtatt aatgcaattt gtcgtcaata 1458361 cacctgtagc ggcatttatg aatttcttaa caaactggct tgaaagcctt ggtactggaa 1458421 accttgtgtt aatgggtatt atcttgggcg gcatgatggc gatcgatatg ggcggtccgc 1458481 ttaataaagc agcctttacg ttcggtatcg ccatgatcga tgcaggcaac tatgcgcctc 1458541 atgcagcaat catggccggc ggtatggttc ctccgcttgg tatcgcactt gcaacaacca 1458601 ttttcagaaa caaattcact cagcgtgacc gtgaagctgg tattacatgc tatttcatgg 1458661 gagctgcttt cgtaacagag ggagcgatcc catttgctgc ggctgatccg cttcgcgtca 1458721 taccagctgc tgtagtcggt gcagctgttg ccggcggatt aactgaattc ttccgagtaa 1458781 cgcttccggc gcctcatgga ggagtattcg tagctttcat tacaaaccat ccgatgcttt 1458841 accttttaag tatcgtgatc ggtgctgtcg tgatggcaat tatcctcggt atcgtcaaaa 1458901 aacctgttac agaaaaataa gaaaaaaagc gtccttggtt cgaaaggacg ctttttctta 1458961 tccggccggc agggagcgcg gttaagttat gtattttatt cttttttatg ataaagtaaa 1459021 agaagagaaa caactgacat agcaattgtc taggaggaaa cactttgacc gaggaaaaaa 1459081 atacgaatac tgagaaaacg gcgaagaaaa aaaccaatac gtacctggaa tggggtaaag 1459141 cgattgtcat cgctgttctg ctggctctcc tgatccgtca ctttttgttt gaaccgtatt 1459201 tagttgaagg ttcatctatg tatcccacat tacatgacgg agaaaggctg tttgtgaata 1459261 aaacagtcaa ctatatcggc gagctgaagc gcggagatat cgttattatc aacggtgaaa 1459321 cttctaaaat ccattatgta aaaagattga tcggaaagcc tggagaaacc gttcaaatga 1459381 aggatgacac gctttatata aacggtaaaa aagtagccga gccttacttg tctaaaaaca 1459441 agaaggaagc agaaaaactt ggtgtcagtc tgacaggaga ctttggaccg gttaaggttc 1459501 cgaaaggcaa atactttgtc atgggagata accggctgaa ttctatggac agccgaaacg 1459561 ggctgggact gatcgcggaa gatcgaattg tcggcacatc gaagtttgtc tttttcccgt 1459621 ttaacgaaat gcgtcaaaca aaataaaaac gccttgctgg cctaggacag caggcgtttt 1459681 tattttgaaa aagaagcgac caatgcaatg cataaaaccg tgatgaacac tgaaccgata 1459741 atagccagca cactgaagaa aaggtgaacc tgtttgttct cttttccgcg cttttctaat 1459801 agccgtttag aaaaaatgtg cgaaaatatg taaataaggg ctatgcctat atataagccg 1459861 atatctttgg cggtaaagcc tgttacggca aggtaaaagc ccgtaaaaaa gatcagtaag 1459921 caatattcag taagtgttaa aagcctcaac gtgttcctcc atgagagtgt gtaattttcc 1459981 aggcggatgc attctctctc tttaattgta acacagctgg ctggtttggg tgtataagtg 1460041 ttttctctct gttttatcag ggaatcattt ctcttgccct gcattcatgg tatactttta 1460101 ttgatgatag acatgatgga ggataataaa tgattgctgt aaataatgta agcttgcggt 1460161 ttgcggatcg caagttattt gaagatgtta atattaaatt taccccaggc aactgctatg 1460221 ggttaattgg tgcaaacggt gccggtaaat caacgtttct aaaggtgctg tcaggcgaaa 1460281 tcgagcctca gacaggcgac gtgcatatga gtcctggcga gcgtcttgcc gtcttgaagc 1460341 agaaccattt tgagtacgaa gagtatgaag tgctgaaagt ggtcattatg ggccacaaac 1460401 gcctgtatga agtcatgcag gagaaagacg ctatttacat gaagcctgat ttctcagatg 1460461 aggatgggat tcgtgctgct gagctagaag gtgaattcgc ggaactgaac ggttgggaag 1460521 cggaaagtga agctgcgatc ctgttaaaag gccttggtat ctcagaagat ctgcacacaa 1460581 aaaagatggc agacctcggc ggttcggaga aggtaaaagt tctcttggca caggcattat 1460641 tcggcaagcc ggatgttctg ctgctcgatg agccgacgaa ccacctggac cttcaggcaa 1460701 ttcagtggct tgaagagttt ctgattaact ttgaaaacac agttattgtc gtatcccatg 1460761 accgtcactt tttaaataaa gtatgtacgc acattgccga ccttgatttt aacaaaattc 1460821 aaatctatgt cggaaactat gatttctggt acgagtcaag ccagctggcg ttaaagcttt 1460881 ctcaagaagc gaacaagaaa aaagaagagc agattaaaca gcttcaagag tttgtcgcta 1460941 gattcagcgc caatgcgtct aaatctaagc aggctacatc aagaaagaaa cttctcgaaa 1461001 aaatcacgct ggatgatatt aaaccgtctt cccgccgcta tccttatgtt aacttcacgc 1461061 cggaacggga aatcggaaat gatgttcttc gcgtggaagg cttaacaaaa acaatcgatg 1461121 gcgtaaaggt gcttgacaat gtcagcttta ttatgaatcg agaagataaa attgctttca 1461181 ctggccgaaa tgaacttgct gttactacgc tgtttaaaat catttccggg gaaatggaag 1461241 ctgacagcgg aacgtttaaa tggggtgtta ccacatctca agcgtatttt ccaaaagaca 1461301 acagcgaata tttcgaaggc agtgatctga accttgtaga ctggcttcgc caatattctc 1461361 cgcacgacca aagtgagagc tttttacgcg gtttcttagg acgcatgctg ttctctggag 1461421 aagaagtcca caaaaaagca aatgtacttt ccgggggaga aaaggtccgc tgtatgctgt 1461481 cgaaagcgat gctttctggc gccaatattt taattttgga tgagccgacc aaccatttag 1461541 acctagagtc cattacagcg ctcaataacg gcttaatcag ctttaaaggc gctatgctgt 1461601 ttacttccca tgaccatcag tttgtgcaga ccattgccaa cagaattata gaaattacac 1461661 ctaacggcat cgtcgataag caaatgagct atgacgagtt ccttgaaaat gctgatgtgc 1461721 agaaaaaatt gactgaacta tacgccgaat aaaaaagcag agatttctct gctttttttg 1461781 atacctaaat gtgaaaggag atcacaacat gaaatttttg gttgtcggag caggtggagt 1461841 aggcgggtat attggcggac ggctttcgga gaaaggaaat gatgtgacat ttctcgtgcg 1461901 ccaaaaacga gctgagcagc ttaaaaaaac cgggcttgtc atccatagtg aaaaagggaa 1461961 tgtatcattt cagcccgaac taatcagtgc cggagaaaca gggcaatttg atgtcgttat 1462021 cattgcttct aaagcatact cgcttggtca agtgatagag gatgtcaaac catttatcca 1462081 tcaagaatct gtcattatcc cttttttaaa tgggtaccgc cactatgagc agctatttgc 1462141 ggcattttca aaagaacagg tgctgggcgg cctgtgtttt atagaaagtg ctttagacaa 1462201 caaaggagaa attcatcata cgagcgcatc gcatcgtttt gtatttggag aatggaacgg 1462261 cgagcgtacg gagcggataa gagcgcttga agaggcattt tcaggtgtga aggctgaagt 1462321 catcattagc gggcatatcg agaaggacat ttggaaaaag tatctcttta ttgcagcgca 1462381 agcggggatc acaacgttat ttcaacgacc gcttggccca atcctcgcca cagaagccgg 1462441 acgtcacacg gcccaaactc ttattgggga aatttgcact gttttacgaa aagaaggtgt 1462501 tccggctgat ccggctcttg aggaagagag ctttcgtacg atgaccagca tgtcttacca 1462561 tatgaagtcc tccatgcttc gggatatgga aaacggccaa acgacagaag gcgaccacct 1462621 gcatggattt ttgattgaaa aagcaaaacg tttatctctc gctgcaccag tattagaaac 1462681 cgtttatgcg aatctgcaaa tgtatgaagc agaaaaataa aaaaaggagg cggaaaagcc 1462741 tccttttatt tacttaaaaa gcccaatttc cgtttctgaa gataggctct cttttcccgt 1462801 ctgccgtaat tccgtcaata ttcatatcct tagaaccgat cataaagtcc acgtgtgtaa 1462861 tgctttcatt taggccttct ttgacaagct cttcacgaga catctgcttt ccgccttcaa 1462921 tattaaaggc ataggcgctt ccgatcgcca aatgatttga cgcgttttca tcaaacagcg 1462981 tgttatagaa aagaatgttt gattgtgata taggcgaatc gtaaggaaca agtgccactt 1463041 cacctaaata gtgagaacct tcatctgttt ccaccagttc ttttaaaata tcctcacctt 1463101 tttcagcttt aatgtcgact atacggccat tttcaaacgt cagggtgaaa ttttcaataa 1463161 tatttccgcc gtagcttaat ggttttgtgc ttgataccac tccgtcaacc ccgtcttttt 1463221 gcggcagcgt gaacacttct tctgtcggca tattggccat aaactcatgg ccactttcat 1463281 tcacgcttcc cgcacctgcc caaacatgct tcctaggcag cttaattgtt agatcagttc 1463341 cttctgcttg ataatgtaag gcagcgtaat gtctctcgtt caaatggtca actttttcat 1463401 gaagattttg gtcatgattg atccacgcct gaaccgggtt gtcttcattt acgcgcgtcg 1463461 ctttaaaaat ttcttcccac agaaggtgga tcgcttcctc ctctgatttg ccaggaaaca 1463521 ccttgtgagc ccagcctgct gatgccgcac ctacgacagt ccagctgact ttgtctgatt 1463581 gaatatattg tctgtatgta tgtaatgctt tgcctgctgc tttttggaat gccgcaatcc 1463641 gtttggaatc tatacctttt agcaagtctg ggttcgacga cacaacagaa atgaaagcag 1463701 ctccattttt ggcaagctct tctctgcctt ttgcttccca ttcaggatat tcttcaaatg 1463761 cttcaaacgg cgcaagttcg tattttaatt tggcgacttc gtcatcctgc caattcacgg 1463821 tgacgttttt tgcgcccttt tcatatgcgt gttttacaat taaacggaca aaatcccgaa 1463881 cgtctgttga agcatttacg actacatact ggcctttttg gacattaacg ccgacttcta 1463941 ccgccagctg tgcatatgta tttaatttct gtgaaaatga atccatgaat cattcctcca 1464001 agcttttttc tcatcatatc aaatatgatc ctataaagga aagaaggagc ccaaagtgaa 1464061 aaacccaaaa cgacacgtct tgggtttttt caatattatg gatgattcag ttttacagtg 1464121 ccgcctgcag gcgaatgggg catatttgcc aaagaaatgc tcatgcctcc aagaataatt 1464181 ccgcttaaaa tggctgcgat cgctactctt cttcctaaat ctcttagcat ctgtttcctc 1464241 cttaacgttt ctccatttcc cacaatatga aggaagtgag gaaaaaagaa gcaagaaatt 1464301 tgccgcgtgt gagaattttg cgggtaaaga ctatttaatt gccttttgca gcttatcaat 1464361 cacttctaaa gaacggcctg tgccgattgc tacagattca agcgggtttt gcgccacgtg 1464421 tacaggcacg acaatctctt ctgtgagcca ttctttaatt ccattaagga gcgcgccgcc 1464481 gcctgttaaa ataacgccgc gatcaacaat atctccgctc aattcaggcg gacagtcctc 1464541 aagtgtcgct ctgatggctt caagaatatg caggagggat tcacgcattg catcttgaat 1464601 ttcgttggat tgaagcataa tggtttttgg aagacctgtc acgaggtcac gtccccgaat 1464661 ttccattgcc tctggtatat gttcaatcag agcatggcca atttccattt ttacctgctc 1464721 agctgtgcgt tcgccgatca gcaaattgta ttttttacgg acgaaagaaa cgatatcctc 1464781 atcaagctgg tctccgccga tcctgataga atggcaggaa acaacgccac cgaaggaaat 1464841 aatagcgacc tctgtcgtcc ctccgccgat atctactacc acattggcaa ccggctcatc 1464901 aaccggtaaa tccgctccga tggcggctgc aactggctct tcgattaaat gaacgttttt 1464961 cgcgccgcaa tttttcaccg catcactgat ggcgcggcgt tctactgctg ttgagcctga 1465021 tggtgtgcaa acgactacgt tcggttttct gaacgacatg ccgatgcttt ttgcggcttt 1465081 tttcataatg tgctttagca ggtcagttgt catatcatag tctgcgatca cgccatcttt 1465141 catcggtctg acagcgacaa tttttcccgg tgttttaccg atcatgtttt tcgcgtcagc 1465201 tccgattgca agcactgctt ttgtcgtcgt atccactgcg acaacagatg gttcatttag 1465261 gataatccct ttatttttgc tgtaaacaag tatattagct gttcctaagt caatcccgat 1465321 ttcagttgat tgaaacatgt tttcacccaa tctctatcct aatttaatat gattctacat 1465381 ttaaagtttc tcagaaatac tgcgattttt gggggtgtgc gtcggtaaag aaatgttttt 1465441 gtaaaaaatc aaggaactgt gtaacagaag taatacattt ttcggtttta tggaaaaaat 1465501 atcttgtaat tcttatagaa agcgggaaac tttttcaaag tttcattcgt ctacgatata 1465561 ttgaggtaca tccttaaaac attacatgag aaaagaaaca tttaaaggaa gaagggtttt 1465621 tatgaaatca ataggtgttg tgagaaaagt agatgaatta ggccgcattg tcatgccgat 1465681 tgagttgaga cgggcattgg atattgccat aaaagacagc attgagtttt ttgttgacgg 1465741 agataaaatt atcttgaaaa agtacaaacc tcatggcgtt tgtttaatga ctggagaaat 1465801 cacttcagaa aataaagaat acggcaacgg taaaattacg ctaagccctg agggtgcaca 1465861 gctgcttctc gaagaaattc aagccgcttt aaaagaataa aattatgcta aaaaaggcgg 1465921 agtgatatca tctccgcctt ttttgcgtgc caatttttga ttaccgccgc ctaagataag 1465981 acatcaagat atttggtaat gaatgatttg ggatacttta catattttac tcaattattt 1466041 gtcgaagaat ggtacaataa gtagagaaac acaagcggca ggtggtcata tgagaaaata 1466101 tcaagctcgt atcatttcca tcattttggc aatgattttt ataatgtttt gggattattt 1466161 attttatttt ataggcaaaa acccgattaa ttggcctgtt gatattgtgt atactgcagt 1466221 cacgctggta agtgtctgga tgttggctta ttatattgat gagaaacagc agctggttaa 1466281 gaaaatgaag gataacgaat ggaagtataa acagctttct gaagaaaaaa accgcatcat 1466341 ggataatttg caggaaatcg tatttcaaac gaatgcaaaa ggtgaaatta catatttaaa 1466401 ccaagcgtgg gcatctataa ccgggttttc aatcagtgaa tgtatgggaa caatgtataa 1466461 cgattacttc ataaaagaaa agcacgtagc cgaccacatt aacacccaaa tccaaaacaa 1466521 agcgtcttct ggcatgttta cggcaaaata cgtgacaaaa aacggcacga ttttttgggg 1466581 agaagttcat tataaacttt actatgaccg ggatgaccaa tttacaggca gcctgggtac 1466641 aatgtcagat atcactgagc ggaaagaggc tgaagatgag ctcattgaga ttaatgaacg 1466701 gctggcgagg gaatcccaga aactatcaat cacaagtgaa cttgccgcag gtattgctca 1466761 tgaggtcaga aaccctttaa catctgtcag cggtttcctc cagattatga aaacacaata 1466821 tccggacaga aaagactatt ttgacatcat cttttcagag attaaaagaa tcgatttagt 1466881 gctcagcgag ctgctgctgc ttgcaaaacc gcaggcaatc acatttaaaa cacaccagct 1466941 taatgagatc ttgaaacaag tcacgacatt gcttgatacc aatgcaattc tgtccaatat 1467001 cgtcatagag aaaaatttca aagagacaga tggctgtatg attaatggag acgaaaatca 1467061 gctgaagcag gtctttatca acatcattaa aaacggaatt gaggcaatgc caaagggcgg 1467121 tgtcgtaacc atttcaactg ctaaaaccgc ctctcatgca gtgataagcg taaaggatga 1467181 aggaaacggc atgccgcagg aaaagctgaa gcagattggc aaaccttttt attcaacaaa 1467241 agaaaagggc actggactgg gacttcccat ttgtttgaga atcctgaagg aacatgacgg 1467301 ggaattgaaa atcgaaagtg aagctggaaa aggcagcgtc tttcaagtgg ttttgccttt 1467361 aaaatcagac agctgagagg agaaaaataa agtgaactcg cttctgtttg tatacgggac 1467421 attaagaaag catgaaaaaa accatcattt gctggcacaa tcggcatgta tcaatgagca 1467481 ggcgagaaca aagggaagtt tgtttgctgc aaaagagggg cccacagttg ttttcaatga 1467541 tgaagatgaa ggctatatat atggcgaagt atatgaagca gatgaattgt gtatacataa 1467601 gctcgatcaa ttttttcaag gatatcataa acaaacggtg tttgtagaaa cggatgtcgg 1467661 gattaaaatt gcgcttattt attttatgaa caaagacggg tgtgccggtt ttacgaaaat 1467721 aagcagcggc gactggaaag aacatcagat gatcagcaaa tcgaaaaatc ccatttatta 1467781 ttttgcctat ggatcatgca tggataatgc ccgctttcaa aaagcgggag tcgatcacta 1467841 ttttcaagat ccagtaggaa gagctgtttt aaaaggatac acaacccgct tcacgctaaa 1467901 aagggaagac ggttcaagag cggacatgtt ggaagacgga ggaacaacag aaggcgtttt 1467961 ataccgtatc ccttattctg ctctctccta tctatataaa agggagggcg tcgaatctct 1468021 tacgtatcgg ccggcatttg tagacgttga agctggcgga aggcactaca aagactgttt 1468081 aacctttctc gtcctccaaa aagaagcgga aattgccccg cctcagcact atcagattga 1468141 aatcgaacgc ggagcggagc tgtatttgtc gcctgagttt actgaaaagc tcaagcggca 1468201 tatgaattcg ctgccaaaag gataacactg taacaaaaga atatgataaa atttgatcaa 1468261 tatcatgtca tataaaggag caccacgatg aaaaaagaat ttgcggtaat tgggctgggc 1468321 cgttttggtg gcagtatttg caaagcatta agcgaagaag gcgtcgaggt tatggcaatg 1468381 gatatcgatg aagataaagt caacgagtat gccaagattg catctcacgc agttatcggt 1468441 gattcgacag acgaatctgt cctgaaaaat ttaggcctgc gaaattttga ccacgttatt 1468501 gtagcaatcg gggaaaatat tcaagcgagt attttaacga cactcattct gaaagaactt 1468561 ggcgtccata cgattacagt taaagcgcag aacgattatc acgaaaaagt gctgtctaaa 1468621 attggtgcgg atcacatcgt ccacccggaa cgcgatatgg caaaacgaat tgcgcataat 1468681 atcgtgtcca acaatgtact tgactatttg gagctgtctg aagagcatag tcttgttgaa 1468741 atcgtagcta acagccgcct ggctggaaat acgcttctcg atttagatat tcgcgcaaaa 1468801 tacggtatta acatcgtagc cataaaaagg ggcaaggaag tcatcgtatc accgcttgca 1468861 accgaagtca tccaccaaga agatatactc attgttattg gatcagttac agacatctcc 1468921 cgtttcgaaa aaagagttct tcatacaaaa tagcagccaa ataagccgtc ctcaaagggc 1468981 ggtttttcat attatcagaa tataacaact ttaatgaact gagcgtcaat ttcttaaaat 1469041 ttcattgact aagcacaggc gttccgatag catattgtac catataataa aaaaaggagg 1469101 ggcctatttg aataaagaag cgctagtcaa taggctgaat gcttcagcca aaagacaaaa 1469161 agctgatatc gtcattaaaa acggaaaaat catggacgta tataatcaag aatggatata 1469221 tgaagatatt gcgattacag atggagttat tgtaggcctc ggtgagtatg aaggcgaaaa 1469281 tatcattgat gcagagggac aaatgattgt tccgggtttt attgatggac atgtacatat 1469341 tgagtcgtca atggttacac cgattgagtt cgctaaagca gtgttgcctc atggcgtgac 1469401 gacggttgtt acagatccgc atgagatcgc gaatgtgtct ggtgaaaaag ggattgagtt 1469461 tatgcttgaa caagctcggc atacaccgct gaatatccat tttatgcttc cttccagtgt 1469521 gcctgccgca agttttgagc gatcaggcgc aattctcaaa gctgccgatc tcaagccttt 1469581 ttatgaagaa gaagaagtat tagggctggc tgaagttatg gattatgtgt cggttcagca 1469641 ggctgaaaaa gacatggttc agaaactgct tgatgcccgt gtggcaggaa aaaggataga 1469701 cggtcattta gctggtttat caacagacct cattaacatt tacagaaccg catttgtctt 1469761 aaacgaccat gaagtaacat cgaaggaaga agcccttgat cgtatcagaa ggggcatgta 1469821 tgtcatgatg cgtgaaggat cagtcgccaa aaacacgctc aatgtgctgc cggcggtgaa 1469881 tgaaaagaac gcacgccggt tctttttctg tacggatgat aagcatgtgg atgatttatt 1469941 gtcagaggga agtgtaaacc atcaggtgaa aatggcgatt caagccggac ttaatccgtt 1470001 tttagcctat cagctaggaa gcctcaatgc agccgaatgc tacggattag atacaaaggg 1470061 agcgattgcc ccgggttttg acgctgattt gctttttgta tctgatctgg aaaatgtcac 1470121 tgtcacaatg acgatggtaa aagggcagac tgttgctgaa gacagcaaag cggtctatca 1470181 ggatcatgct tcaactgcag caccagatca ggcactgctt gattctgtta agcttgctgc 1470241 tcctcttaac aaacaggatt ttcatatgcc aatcgattca gagcagcaga tcaatgtcat 1470301 tcaaatcata ccaaatcagc ttgaaacacg attagtacaa gttccggctc ctgttgcccg 1470361 cgaatttgag cctgacactg agcttgattt gttaaagatt gcagttgtcg agcggcataa 1470421 aggattaaaa gaaaccggac ttggtgttgt gaaaggtttt ggattcaaga gcggagcgat 1470481 tgccacaacc atttcacacg actcccataa tattattgcc gtcggaacga atgatgagga 1470541 tatcgcggcg gcagttaata agctgcagga aattggcgga ggattaacaa ttataaaaaa 1470601 tggggaagag ctccattcag taccgctgcc gattgcaggg ttattatccg accaatctgc 1470661 agagcaagtg aatcaaagct tgctgacgct tcatgataaa ttgtcgttaa tcggtttcac 1470721 aggcggattt aatccatttt tgacattgtc gtttttagcg ttgcctgtca ttcctgatat 1470781 taaaatgacg actacgggat tattcgatgt aaaatcattt caacacatat cactgcaata 1470841 aaaagaggca ctcccttagg gagtgcctct ttttttaaac ctccataatg atcggcagga 1470901 tcattggacg gcgctttgtt ttttcgtaca agaaaggtgc aagcgtgtct gtaatttcgt 1470961 ttttgatttc agaccattga gtcgtttttc gttccattac tttttgtaag tgatttgaaa 1471021 tgagctcttg agcgtcgttg atcaagtcac cagattctct catgtacaca aatcctctgg 1471081 aaatcaaatc aggacccgct gaaatcttga agtcgtccat gtcaatgctg acaacaacga 1471141 tgacaagtcc ttcttcagag agaattctgc gatcacgaag tacgatattg ccaatatcac 1471201 cgataccgct tccgtcaatg tacactgaac cggacgggat ttttcctgca actgaagcct 1471261 catcgccttt aagtgctaat acttcaccat tatccatgat aaagcagttt tcctctggga 1471321 tgccacaatc tgttgcaagt ttgacatgca tcttttgcat tctgtactca ccgtgaatcg 1471381 gcatgaagaa tttaggcttg attaaacgaa gcatcagctt ctgttcttcc tgtccgccgt 1471441 gaccggatgt atggatatcg ttaagagggc cgtgaataac ctcagcaccc gcacgataca 1471501 gctggttgat tgttcgactc acgctgattg tgttgcctgg gataggggat gaagaaaata 1471561 cgactgtatc cccaggattg attgaaattt ggcggtgtgt gccgtttgca attcttgata 1471621 acgccgccat tggttcccct tggcttcctg tacataaaat tgttacttta ttagcaggca 1471681 tacgattgat ttcgttatgc tcaataaacg tatttttagg acagttaata taaccgagtg 1471741 tctgtccaat ttcgatagcc gattccatac tgcgtccaaa tacggcaact tttcttccat 1471801 tttgtacagc agcttcaatt acctgctgca agcggtgaat attcgacgca aatgtggcga 1471861 agataattcg gccgtccacc ttgcggaaaa tgtcatgaat gctttctcct acacggcgct 1471921 cagacatggt aaactccgga ttttcactgt ttgtgctgtc tgaaagaagg cacaaaacgc 1471981 cttctttacc gatttcggcc attttcgtta agtttgccgg ctcgccgact ggagtaaagt 1472041 cgaatttgaa atccccagta tgtacgatgt ttccgggcgg cgtttttaca acaatgccgt 1472101 aggaatccgg aatactgtgt gttgttctga agaatgacac agccgttttg cggaacttta 1472161 caatatcatc ctcgccgata atgttcagtt tcgtctgtct caataatcca tgctcttcaa 1472221 gtttattccg aagtaagccg atcgcgagtt ttccgccgta tacaggaata ttcacttgtc 1472281 tgagcaggta tggaataccg ccgatgtggt cttcgtgccc gtgggtgata aaaagccctt 1472341 taattttatc ttcgtttttg actaaatacg tataatcagg gatgacgtag tcaattccga 1472401 gcagttcgtc ctcgggaaac ttgatccccg catcaatcag tacaatttca tcctggaatt 1472461 gcaccgcgta cgtattttta ccgatttcgc ccaaacctcc gagggcgaaa acagcagtct 1472521 gatcattttt tacaaatttc ataccgctca taactccaat actttaaaat tttcgctctg 1472581 ttgttcatat tctaagaatg caccatcaac aggtgtaata aactcaatat taaatttctt 1472641 ttctttcagc tttgttctga cgtcacgctc agatacgcct tcaatataaa gtgaatctgt 1472701 cttttcccga acaggtactt cgtcagcctt ctcttgataa aataccttat aaatcattcc 1472761 aaatctctcc ttaaatgccg tatgttagac tcgctcattc tattatattc gaaaacggaa 1472821 tataaggaaa gccttgagca aaataaggat ctctcaaaaa gtgaaagatc ccttgtcagg 1472881 caattgcttt cttacggagc attccgttcc attgtcttct gagtttcttt cttaatttac 1472941 gcagcattag ccagtccctc ctttaatgaa aaatttgtcc cagagttctt ttatacaaat 1473001 agtatacgga gattgaggaa gacttttcgt ggttattaat ggaatttaat atgatttttg 1473061 aacgaaattg tttgctgaat gacaatcttt ttgtatgatg agggtgggaa ttgcagacca 1473121 agacgataaa ggggaagttg cgatggattc taaattaatc ttttttgata ttgacggcac 1473181 aatatatgat catgataaga atataccgga aagtacgaga aaaaccgtgg cggagcttca 1473241 gcgccaaggg catcatgtgt ttattgccag cggccggtct ccatttttgg ttaagccgat 1473301 tttggaggag ctgggcatcc actcatttat ttcctacaat ggacagtttg ttgtctttga 1473361 aaatcaagtg atttataaaa atccgctgcc tgaaaatgca atcaggcgat tattaaagca 1473421 ggcggatgaa ggcaagcatc ctgttgtgtt tatggctgag gacacgatga aagcgactgt 1473481 tgcggatcac ccccatgttc tcgagggaat cggcagcctt aaaacagatt atccagagac 1473541 cgatgacctt ttttatgaag gaaaagaaat ttttcagctt cttttatttt gtcaggatga 1473601 agaagaaaaa gcttatgccg cttttcctga gtttgatcta gttcgctggc atgagctatc 1473661 gactgatgtt ctgccgcacg gaggttcgaa ggcagaagga atcaaaaaag tgattgagcg 1473721 tcttccgttt gatatcggcg atacatatgc tttcggcgac ggattaaatg atttgcaaat 1473781 gattgaatac gttgggacag gcgttgctat gggaaatgct gttcccgaac tgaaagaaat 1473841 cgcggacttt gtaacaaaac cggtggacga ggatggaatt gcatacgctg tcaaagaatt 1473901 gggcctttta aaataaagaa acggctggca ttgtgccagc cgttttctct tttagcgctc 1473961 aattgcgatt gcattttcag gttctttgaa aggattttcc ttatcaatat gatcatagaa 1474021 cataacgccg ttcaaatgat cgatctcatg ctgaaacaca atagccggaa atccttttaa 1474081 acgaatatca atattttcgc cttctagtgt tgttcctttt actctgatgc gagcatagcg 1474141 gggaacataa ccgggaatcg cttcatccac agagaggcag ccctcgccgc ttgttaagta 1474201 gcttttttca actgaatggc tgacgatctt aggattaaac agagcatagc tgtataattt 1474261 accggaagca tcttccgcat gaacggcgat cattcgtttt ttgatattaa tttgaggagc 1474321 tgcgagtcct acgccagggc gcagcttgta tttttcggct aattctggat tttggctgtt 1474381 tttaacaaat tcgatcatgt cggccagctg ctgtttttct gcatcagttg gaggcagctc 1474441 aacaggttcg gcagtctctc tgagggctgg atggccgtca cgtacgatgt tttccatagt 1474501 aatcaagaaa cttcactcct aaagcttaat atgtaaatta tatcggattt cttcacaaag 1474561 gtgcaacgaa acgaatgacc agccgtatat ggctggtcaa tttcatgctg tgtggttagc 1474621 aacagcctcc acctaaataa gcagctccga caatgattaa cagaatgaat aaaacaacga 1474681 ttagcgcaaa ggtgcggccg tagccatatc cgcagccacc atatccgtaa ccaccataac 1474741 tgcagcagcc tccgccgtaa ccatatccat acatattaca taacctcctc ttttaattac 1474801 gccagagcct ttataagtag gcatagcgtc taatataacc tatgtaaaaa caaaaaagtt 1474861 gtatggtcat ctgtcctgat ttttcacttt tttgatttaa tttcagtatt gcatttatac 1474921 agcacggcta ttgccaaatg tccccatgga ttctatagta gaaattgtca agattggggg 1474981 atttaacgtg aaagacgcta taaaacggcg gcctggaatc aagatcggag ctttttgtgc 1475041 catggcactg atattaacag gatgcatggg acaggacccg gttgattcac ttcatcattc 1475101 attagaaaaa gccgcggaat cggaaaagcc gtttcaagaa gaacaaaaca cactcaaaga 1475161 attagaggcc aaagaaaatc agctttacga tagtgttatg aagctcaata tggatgatta 1475221 taaaaaaatt gttgctttat ctaataaggc gcttgaaaat gtcagcaagc gcgaagaaca 1475281 cctaaagctt gaaaatgaca gcatgaaaaa atcggaaaca gaatttgagg aagcaaaaac 1475341 gtcagcggaa catattaagg aaaaagacat aaaagaaaag gccgatgccg cagcaaacca 1475401 tatggagaaa agatatacat catatggcac tatgtataaa gagtataaaa aagcgcttga 1475461 gcttaataaa aaactgtata tgcagctgaa agacaaagat ttgacaagag atgatctgga 1475521 tcagcagatc gataaagtca atgcttctta tgaaaagatc cttaaatata gcggagaatt 1475581 taatgaacaa accgaaaaat ataataaagc ccgggaagat ttatatgatg ctgcaggcta 1475641 tcgtgtgaaa aagagctgac tcgatcagct ctttttttga atgaaatgcg attcggattt 1475701 cgttcaaaat tttcatttct attgtagtac agcatagtaa ggtatactag tacagttttg 1475761 ggtgcggttg gcatctgttt ttttgatgaa aatgtaaagc gaatacattt attgaaaatc 1475821 agcgatgaaa acgattgacg gttcttcttt atttggtgta aactaatcca tgttaagcgg 1475881 tgttgtatta gttttttaca acttcgaaat aatacagttc aaagcagagt gtaactatcc 1475941 tacataaaag gttttggcaa actggggatc ggctaaaata taatacgact tactgctgat 1476001 actttagggt accctaagtt tgtatgtata aaaggaatgc acgtctaatg actgtttaaa 1476061 agaaaggaag aggtgactta gtatggctgc aaaaacgaaa aaagctatcg ttgacagtaa 1476121 gaagcaattt gatgccatta aaaagcagtt cgaaacgttc caaattttaa atgaaaaggg 1476181 agaagtcgtg aatgaagcgg cgatgcctga tttaactgat gatcaattaa aagagctaat 1476241 gcgccgcatg gtatttacgc gtgtgcttga ccaacgctct atctcattaa accgtcaagg 1476301 acgtctcgga ttttacgctc ctactgcggg tcaagaagct tctcagattg caacgcattt 1476361 cgcgcttgaa aaagaagact ttgttcttcc tggataccgt gatgtgcctc agttaatttg 1476421 gcacggcctt ccattatatc aagcgtttct tttctctcgc ggacatttca gaggaaacca 1476481 aatgcctgat gatgtgaatg ccctttctcc acaaatcatt atcggtgctc aatacattca 1476541 aactgccggt gttgcgctag gtcttaaaaa acgcggtaag aaagctgtcg caatcactta 1476601 cactggtgac ggcggagctt ctcaagggga cttctacgaa ggaattaact ttgccggagc 1476661 ttataaagca cctgcaatct tcgtggtgca aaacaaccgt tacgcgattt caactcctgt 1476721 tgaaaaacaa tctgcagctg aaacaattgc acaaaaagct gtagctgccg gtattgtcgg 1476781 cgtacaagta gacggaatgg atccgcttgc tgtatacgca gcaactgctg aagcacgcga 1476841 gcgcgcaatc aacggcgaag gtccaacact aattgaaaca cttacattcc gttatggccc 1476901 gcacacaatg gctggtgacg atcctactaa atatcgtaca aaagaaatcg aaaatgagtg 1476961 ggaacaaaaa gatccgcttg tacgtttccg tgcgttcctt gaaaacaaag gcttatggtc 1477021 tgaagaagaa gaagcaaaag tgattgagga tgcgaaagaa gaaattaagc aagcgatcaa 1477081 aaaagctgat gctgaaccga agcaaaaagt aactgattta atgaaaatca tgtacgaaaa 1477141 aatgcctcac aaccttgagg agcaatttga aatttataca cagaaggagt cgaagtaagc 1477201 catggcgcaa atgacaatga ttcaagcaat cacggatgcg ttacgcacag aactgaaaaa 1477261 tgacgaaaat gtcttagttt tcggagaaga cgttggtgta aacggcggcg tattccgtgc 1477321 gacagaagga ttgcaaaaag aattcggtga agaccgtgtg tttgacacgc cacttgctga 1477381 atctggtatc ggcggtcttg cccttggttt aggcttaaac ggcttccgtc cggtaatgga 1477441 aatccaattc ttcggatttg tttatgaagt aatggattca gtttctggcc aaatggctcg 1477501 tatgcgctac cgttctggcg gacgctggac ttcacctgta acaattcgtt ctccattcgg 1477561 cggcggtgtt catactcctg aacttcacgc tgacagcttg gaaggtcttg ttgcacaaca 1477621 gcctggtatc aaagttgtta ttccatcaac tccttacgat gccaaaggac ttttaatttc 1477681 tgcgatcaga gacaatgatc ctgttgtctt cttagagcat atgaagcttt accgttcttt 1477741 ccgtcaggaa gttcctgaag aagaatacac aattgagctt ggaaaagctg acgtgaaacg 1477801 tgaaggtact gatctttcaa tcatcactta cggcgcaatg gttcatgaat cattaaaagc 1477861 tgctgatgag cttgaaaaag acggcatttc tgctgaagtt gtcgaccttc gtacagtaag 1477921 cccacttgat atcgatacaa ttatcgcctc tgtagaaaaa acaggacgcg cgattgtcgt 1477981 tcaagaggca caaaaacaag ccggtattgc tgcaaacgta gtagcagaaa ttaatgaccg 1478041 tgcgatcctg agcttggaag cacctgtact tcgcgttgca gcgccagata cagtatttcc 1478101 tttctctcaa gcggagagcg tatggcttcc aaaccataaa gacgttcttg aaacagcaag 1478161 aaaagtgctt gaattttaat caaactgcat aatcgagagg gaagatgaac gttttccctc 1478221 tattatatat ctgttttcaa tgcttacgat gtaaacttta aaattgctta atcaaactag 1478281 gaggtcgaga actgtggcat ttgaatttaa acttccagat atcggggaag gtatccacga 1478341 aggcgaaatc gtaaaatggt ttgtcaagcc taacgacgag gtagacgaag atgatgtact 1478401 ggctgaagtc caaaatgata aagcagtagt agaaattcct tcacctgtta aaggaaaagt 1478461 attagaatta aaagttgaag agggaacggt tgcaactgtt ggacaaacga ttattacgtt 1478521 tgatgcacct ggttacgaag atcttcaatt taaaggcagc gacgagtctg acgatgcgaa 1478581 aactgaagca caagttcagt caactgcaga agctggacaa gacgttgcga aagaagagca 1478641 agctcaagag cctgcaaaag ctactggcgc aggacagcag gatcaagctg aagttgaccc 1478701 gaacaaacgc gtgatcgcta tgccttccgt acgtaaatat gcacgtgaaa aaggtgtaga 1478761 catccgtaag gttactggtt caggcaacaa cggacgtgtt gtaaaagaag atatcgacag 1478821 ctttgtaaac ggaggagcgc aagaagctgc accgcaagaa acagctgcac cacaagaaac 1478881 agctgctaaa ccggctgctg caccagctcc agagggcgaa ttcccagaaa cacgcgaaaa 1478941 aatgagcggt atccgtaaag caattgcaaa agcgatggtt aactctaaac acactgctcc 1479001 tcacgtaacg ttaatggacg aagtggacgt aacaaacctt gttgcacatc gtaaacagtt 1479061 caaacaggtt gctgctgatc aaggaatcaa gctgacttac ttgccttacg ttgtaaaagc 1479121 tcttacatct gcactgaaaa aattccctgt tttaaacacg tcaattgacg ataaaacaga 1479181 tgaagtcatc caaaaacatt acttcaacat cggtatcgct gctgacactg aaaaaggctt 1479241 gcttgtaccg gttgtgaaaa atgcagatcg taaatctgtc tttgaaattt ctgatgaaat 1479301 caatggcctt gcaacaaaag ctcgtgaagg caagcttgct ccagctgaaa tgaaaggcgc 1479361 atcttgcaca attacaaaca tcggttctgc cggcggacaa tggttcactc cggttatcaa 1479421 ccatccagaa gttgcgattc ttggtatcgg acgcattgca gaaaaagcga ttgttcgtga 1479481 tggcgaaatc gtagcagctc cagtcttagc tctttctctc agcttcgacc accgtatgat 1479541 cgacggagca actgcgcaaa atgcattaaa tcacatcaag cgtttactga acgatccaca 1479601 attaatttta atggaggcgt aatgttatgg tagtaggaga tttccctatt gaaacagata 1479661 ctcttgtaat tggtgcggga cctggcggct atgtagctgc catccgcgct gcacagcttg 1479721 gacaaaaagt aacagtcgtt gaaaaagcaa ctcttggagg cgtttgtctg aacgttggat 1479781 gtatcccttc aaaagcgctg atcaatgcag gtcaccgtta tgagaatgca aaacattctg 1479841 atgacatggg aatcactgct gagaatgtaa cagttgattt cacaaaagtt caagaatgga 1479901 aagcttctgt tgtcaacaag cttactggcg gtgtagcagg tcttcttaaa ggcaacaaag 1479961 tagatgttgt aaaaggtgaa gcttactttg tagacagcaa ttcagttcgt gttatggatg 1480021 agaactctgc tcaaacatac acgtttaaaa acgcaatcat tgctactggt tctcgtccta 1480081 tcgaattgcc aaacttcaaa tatagtgagc gtgtcctgaa ttcaactggc gctttggctc 1480141 ttaaagaaat tcctaaaaag ctcgttgtta tcggcggcgg atacatcgga actgaacttg 1480201 gaactgcgta tgctaacttc ggtactgaac ttgttattct tgaaggcgga gatgaaattc 1480261 ttcctggctt cgaaaaacaa atgagttctc tcgttacacg cagactgaag aaaaaaggca 1480321 acgttgaaat ccatacaaac gcgatggcta aaggcgttga agaaagacca gacggcgtaa 1480381 cagttacttt cgaagtaaaa ggcgaagaaa aaactgttga tgctgattac gtattgatta 1480441 cagtaggacg ccgtccaaac actgatgagc ttggtcttga gcaagtcggt atcgaaatga 1480501 cggaccgcgg tatcgtgaaa actgacaaac agtgccgcac aaacgtacct aacatttatg 1480561 caatcggtga tatcatcgaa ggaccgccgc ttgctcataa agcatcttac gaaggtaaaa 1480621 tcgctgcaga agctatcgct ggagagcctg cagaaatcga ttaccttggt attcctgcgg 1480681 ttgttttctc tgagcctgaa cttgcatcag ttggttacac tgaagcacag gcgaaagaag 1480741 aaggtcttga cattgttgct gctaaattcc catttgcagc aaacggccgc gcgctttctc 1480801 ttaacgaaac agacggcttc atgaagctga tcactcgtaa agaggacggt cttgtgatcg 1480861 gtgcgcaaat cgccggagca agtgcttctg atatgatttc tgaattaagc ttagcgattg 1480921 aaggcggcat gactgctgaa gatatcgcaa tgacaattca cgctcaccca acattgggcg 1480981 aaatcacaat ggaagctgct gaagtggcaa tcggaagtcc gattcacatc gtaaaataat 1481041 tttcatatca aaaacagccc cgctttgagc gagggctgtt tttttatttt gacagcacat 1481101 gctgtaatgg tttaatgatg tcttctttct ttttcacaca tccctcgatt ttcaccacga 1481161 catggcgctg atcaacaacc ataagggtag ggacagtttc aatctcatct tcccagcctt 1481221 cttttttatc atagaccttc attttatcta tttgctcggg ataatctttt tctaaatcaa 1481281 gcagtgcatc gtaataaggc gcttcctggt ctatttggtt ctcatcagaa aaaaacagga 1481341 tttgtgtatg atgaatgttg tcaatccggc tttttttcat cggattgatg gtggaaagcg 1481401 tacagcccga taaagcaaat actattatca gcatggggaa taccgcgcga tatcgcatct 1481461 atcttctcct ctgtataaac agtagttaac tagctttagt ttatcacgag agacggctta 1481521 atctgcttct tgttacctaa ttgttatata attgaaaccg tttttaaagt gagattacat 1481581 attatatcaa tcgtttaaaa tagcaacctg gggtatattg aattttttgc tgcattcttg 1481641 gatgaaagtt caagaaaacg tgcaattaca ttatgtgctg tggcatatat atcgagtaaa 1481701 gcttctgtat gaagaagata ttgtatgatg gaaaatggaa aaacaaggtg aatatgatga 1481761 tatgaaataa aatgtgttat acagtttgtt gttgacattt taaatgtgac atattaatat 1481821 aataacaaca aaagaaatta agcgttttca aatttcaaag aaatggggaa taagagatgg 1481881 gtacgattgt ttgccaagat tgcaacgaag ccattcatta ctttgaagat gagaaagtga 1481941 caacattata tggaacttgc tgcggacaat gtcaatgtcc tgttgatgaa gagtaaaaaa 1482001 aagcatgcgg cttaaagccg catgcttttt attttttatt gaattgcttt ttgttctttg 1482061 atgacccgga tcatatgtaa agtcgagtcc tcaggtcctt gaacagggag gcctgcgtca 1482121 aggtttttaa aaatgtagct gatgttttct tctgtaataa tttctcctgg gatgaagatt 1482181 ggaataccag gcggatatac catgacaaat tcagcaataa tccgtccgga tgcttctttt 1482241 aatgggatga cttccgtatt tgcatagaaa gcatcacgcg gagtcattgc caataaaggt 1482301 atttctggaa gcagaacctc agtttgctga tgtgttacat cttgttctga catttgctgt 1482361 gcgatctcag ttaaagcctc tacaagccgg tctgcatcat tttggctgtc accaggagtg 1482421 aaaatacaca aaatattgta cagatcagaa agctccacct caatattaaa ggattcacga 1482481 agccattttt ccacgtcatg tcctgtcagg ccaagacttt tcacagagat aatcaatttt 1482541 gtcggatcat agctgtaagc tgctttcgac ccaagaatct cagaaccgac acaataaatg 1482601 ccttcaatct gattgaggcg atctctcgtc tgattggcaa gcttgagtgt ttcctcagca 1482661 agctggcggc cttctgttgc aaggcgtttt ctggcaacat ccaaagaagc gagaagcaag 1482721 taagaagttg acgtagttgt cagcatgctc aggatggatt gcactctgtc tttagataca 1482781 aggccttctc tcatgtttaa aatagagctt tgtgtcagtg atccgcccag cttgtgtaca 1482841 cttgtcgctg ctatgtccgc tcctgcctgc atagccgata gcggcaattc gtcgtgaaaa 1482901 tgaatgtgaa cgccgtgtgc ttcatccaca agcactggca catcaaacga atgagcgagt 1482961 tctacgatgc tttttaagtc ggctgcaaca ccgaaatatg tcgggttgat gacgagaagc 1483021 ccttttgcat ccggatgctc ggtaagcgcc cgtttagcag attcaagtgt aattccgtgg 1483081 gagatgccca attcattgtc aatttcagga tgaataaaaa ttggaaccgc tccggaaaat 1483141 acaatagctg tcataattga tttatgaaca tttcttggaa taataatttt atcaccaggt 1483201 ccgcaaacag ccattaccat tgtcataatg gcgccgcttg ttccttgaac agaaaaaaat 1483261 gtatgatccg ctccaaatgc ttcagcagcc agatcttgtg cttgtttaat aatgcctttt 1483321 ggcgcgtgca gatcgtctaa tggttcaata ttaatcaaat ctatgcttaa cgcgttttca 1483381 ccgataaatt gtctgaattc tgggtccatt cctgcccctt ttttatggcc gggaatgtgg 1483441 aattgaacag gctgtctgct tgcatgcttt ttcagtcctg tgtataaggg tgtttcatgt 1483501 tgcgacaatt gttttcccac ctttgtaatc atacctatgc ataatagtgt gtattaaaat 1483561 cagtttctca accgtttttt agacgtaaaa caaatgaatt atattatgaa cttgaaagaa 1483621 tgtaaagaac aatttatgat caaatgaaga tgctttctct taagggaagt aaatctacaa 1483681 ggagtgaaga aaatggagta tcaatatccg atgaatgaag attggacaac cgaagaagca 1483741 gtggatgtga ttgcattttt ccagcaggtt gagcttgcat atgaaaaagg ggcggatcgt 1483801 gaagaactgc ttaaagctta ccgccgtttc aaggaaattg taccggggaa ggccgaagaa 1483861 aaaaagctat gcggcgagtt tgaggaacaa agtacatatt ctccttatcg cacggtcaaa 1483921 caggcgagag aatctgatca cgcgaagatt aagatgtaag aaaaagagcc gggggatatc 1483981 ccggctcttt tttatgcttg tgttactttt tgggtgagac ggtacagaaa agcaagctgt 1484041 ttaaaggcat cgtcgatacg ctgaaggaat tcctggttat tcatattcag cacttcttct 1484101 ttttggagct ggatgccgca taacagctcg gctttcttta cagtctgcaa acgctcaaac 1484161 agtgtcttca gctgttcctt gtccatttca gactgtttat gtactcccgg ttttgtgtga 1484221 tctgcagacc aaacgaagct gtcagggata tttttcgtaa tggtttcttg gttcacttca 1484281 agcaatttgc cgtattcttc tttgataggg gattcataaa taatcgcgaa ccatacaaag 1484341 acgtggcttt cccataaacc aatttggaaa tgcggcagtt ttttatagcc tcttttgctg 1484401 tttgcgaacg ccacccagct gtcagccggg ggattgacgg atcttcttgc gtgctttgcc 1484461 acatgcggaa acatttcatc tccggttaaa gctgataaag ttggggcaaa atgttcgcct 1484521 agagctgtaa gcttcggacg gaccgtctct tttaatactt ccatgcgcgc gtctaagcct 1484581 tctattgtaa atgtgttaaa gtcttcttca gtgaaacgca tttgtgtcat gattttcctc 1484641 cttcatgcta agtatacata ttttatcaca gttcatacga gcttcaaaaa gattgagcgc 1484701 gtttgaagta aggagaaatg tggtaataaa cgagtaggta aacacacaat tttcagaatc 1484761 atgttgcgcg taaatagaac aatcatacga tataagaagt aatcattgtt gaatggcaaa 1484821 atgggatgct tttttacaaa caaatgatct ctggaagggg cgaaagacaa tgaggcaagt 1484881 tgtaaaagag ggatttaagg aagagaaaaa caatcgtgtt gctgtctgga gactagaggt 1484941 tgattatgaa ttggcaaccc tatatgaagc aatgcagaaa gaaaatgaag agcagattga 1485001 acaaagcaaa aacaaacttg agcgacttag aaaagaatgg attcgtctta acgggtaaaa 1485061 aagcgatagt gaaaacgaac cgcatgaatg gttcgttttt acgtgagaag ggatattttt 1485121 cattttcctt gctttttcat tgccgttatc agtatcctat aaaataaaag gtctacatag 1485181 aagagaggta cgaacgaatg acaaattgga cggaaatcga tgagattgca aagaaatgga 1485241 taagagaagc aggcgcgaga attacacaat ccatgcatga aagcctgaca attgaaacga 1485301 aatcaaatcc gaatgattta gtcaccaata ttgacaaaga aaccgaaaag tttttcattg 1485361 atcgaattca agaaacattt ccgggacatc ggatactcgg tgaagagggg caaggagaca 1485421 aaatccactc acttgaggga gtcgtatgga ttattgatcc gattgatggg acgatgaatt 1485481 ttgtgcacca gcaaagaaat tttgcgattt ccattgggat ttttgaaaac ggtgaaggta 1485541 aaatcggttt aatttatgat gtggtgcacg atgagttgta tcacgcattt agcggcagag 1485601 gagcttatat gaatgaaacg aagctggctc cattaaaaga aaccgtcatt gaagaagcga 1485661 ttcttgccat taatgcaaca tgggtaacgg aaaacagaag aattgatcaa agtgtgttag 1485721 cgccacttgt gaaaagagtc agaggcacac gctcctacgg ttctgccgct ttagagctgg 1485781 caaatgtcgc ggcaggaaga atagatgctt acatcacgat gcggcttgcg ccatgggact 1485841 acgcagccgg ctgtgtgctg ttaaatgaag taggaggcac ctatacgacc attgaaggag 1485901 agccgtttac ctttttagaa aaccacagtg tgctagccgg aaacccatct atacataaaa 1485961 cgatatttga agagtatctt catgctcgga agtaggccat ttgagcagga tgatctcagc 1486021 ttgttagaaa agctcgcgga ggctcatcct gtatggaaag aggaggagtt tggagataaa 1486081 gatgcagaag actatatcat ttcctactcc atgtacaacg gttcatggct tgtatgggaa 1486141 aaagacggta tgcctgttgc cgtcagctac catctcgagt ggtctccttc aaacggtaag 1486201 ccgtggctcg gaacggtcct gattgacccg gctgaagaaa aaaagggaca tgcgaagatg 1486261 atcattgaac agatcagcaa attgcttaga gcgaaacata aagcgatgtt tgcgggagtt 1486321 cccattgagc gcagggaatg gatactgttt ttaagccaat gcggctttga acagctgaaa 1486381 acggaaaaag atgagaaagg caaatcattt atgatcttgg tgaagccttt agcagaagct 1486441 gccgtatgat aatggcagct tatttgctgc atgcgggttc aataaaaagc ctctcaaaca 1486501 ttgagaggct tctgatgatt tgaaaattat ttttttaccg catgaatata atgaatcgtt 1486561 tcaaacgctg acaaattgtc ttttcgatta ctaaagaaaa ggtcattgat gtcgtctggt 1486621 gatagatgtt catagatcag taaaccagat gactctaaca gatgttcaat ctcttgataa 1486681 gtgaaacatg atttcatcgg ttccccgctt gcggcagcca tcttcaccat atgttcaact 1486741 cgattcgacg tcccttttgc tgtaaaaagt gtttcgtccg cataatcaaa aacaatagag 1486801 cttccaggcg ggacatgaga aaataaattg ctgatcaagc ttgcattttc ttcccgtgtt 1486861 acataataag acactccgag aaggctgaag aatgtttttg tgtttttaaa tccttcatct 1486921 aagagaggat catacgaaaa cgttttggtg aaatccatag gaacaaaatg aagatgaccc 1486981 ggaattgtca gatttgcatc cttcagctta ttttttttca attgctgtgt ggccggatga 1487041 tcaacctcga aaacctgtaa gctgttttct aattctggat gccgaaagca gaaagtatcc 1487101 agtcccgctc caagaatgac atactgtttt gcccccagga ttaattcgtt gtgcaagact 1487161 ttttcacaat aagaagcacg tgctaggggc gttggagaca gctggatttg tgcaacccat 1487221 tttaatattt tttcaggatc attttgaaga cgttcggcga tctctttgtt gaaaaacgat 1487281 atttcttgaa tcatattttt actgatgtcg ataaactctt tttcgttaat gagatctttt 1487341 gcgataaaat catcaaaaat aagaggtgtg tcatatcggc tgtgatatgc acgggcaaaa 1487401 gctgaaatta gagacgttaa gctggactca tttttcctca tgaaatgatc ctccacaaaa 1487461 aataagattc ccctggccag gagaatctta ttatacatac aaatatatta atagtaaatt 1487521 ttagcataaa taaatttttt tgtcaatgtt tttgctctta actggacgcg cgatccttca 1487581 catagccacg tgacctgtag cagaattcgt ctatcaatta tgtggactga atcattagct 1487641 tttataaaat gcgcacttgc ggctgcatcc ctctttatgc aaatcaggag cggttttctg 1487701 tctcatggca gcatcttttc gtcgtttcag ctgagagaga aatcaagata tgtaacaata 1487761 aaagcctgag ggatctcagg cttttcctaa tattacaatc caacagcatt ccaggctgct 1487821 tcaactttag cggcatcagt tgagccgtag aggtcacggg cagactgaat gagagctgcc 1487881 ttggcatctt tgaacgtgga agaaggcgtg aggtacgttg ttaacgcacg gtaatagatt 1487941 tgctgtgatt tagatacacc aagttttgtg atggtgttgt aagcggcttt gtttggaatt 1488001 ccgctgtttg tgtgtacacc gccataatcg ccttcatctg tgtttggaag gtttcggtaa 1488061 ttggcgtaat tgtcaggctg gttgtatttt gtagggttgg acaggctgcg aagagcaggc 1488121 tggctgaccg taatgtcttc accgatgtcc cagtcttctg tatcgttaaa atacccgaat 1488181 acgtcagaga aagactcgtt taatgcacct ggctgatttt cataaatcaa gttggctgtt 1488241 tcttgggtga cgccatgtgt catttcatgc gctgtcacat ctaatgagcc ggaaagcgga 1488301 gagaagaatg aaccgtcgcc atcaccgtaa atcatctggt ctcctgtcca tgcagcgtta 1488361 ttgtattgag tgccgtagtg aacggaagaa acgattttac tgcctttgtt atcatagctg 1488421 tttcgtttaa agtttgaata aaaataatcg tacactttac cgaggttata gtgtgcgtca 1488481 acggctgccc gctgtgatga agatgtaaat gttttcgttg tgcttgagac aagcgtgccc 1488541 ggaaggcggc tttgtctgtt ttgcaaatca tatgtgatga tttgggtgcc tgttggtttt 1488601 gaaagatctc ttagaacata ttttccgcct tcataagaga tgttcaaagg aacagttgcg 1488661 ccctttagcg ttgttccgct tccagtggcg gcggcatgtt ctactttatt ttgctgtttt 1488721 aaaatgctgc ctgtttcggc gtcaactaag acttcccagt ttgcaggttc aggctcgaca 1488781 tagcgaatcg tcacgtcgta agcaagacga tagctgccgt cttttgtttc tatcgctttt 1488841 aattcggctt tattgctgtt tttggccgct ccgttagaaa cagcgtctgg tgatttgccg 1488901 atagctttga aagcgagtgc cagcgctttt tcagaagaga ctttttggct gttatctgtt 1488961 tttgcagcag attgattgtg taattcacca ttgaccgcat agacattatc ggatttatcg 1489021 acgtgaacga tcacttgcga atctttaatt ggcactccgt taacgacagg cgcatatcga 1489081 aagtgcttgt atccaagggc atcagtcgtg ctttcaacaa gcttcagcct tttggaaggg 1489141 tcacctttaa aaatgttgct gttctttttc aaaaactgct tgacagcctt gtcatttggt 1489201 gcagagagtt ctgattgcgc aatcgcgttt ttggagagga aatttgtttg attctcttta 1489261 agctgatgac cttcagcagc ctgaacacct ggcaggctga ttgataaact cataaacgaa 1489321 gcagcgacag caacagacaa tttcttacct aaacccacaa taaatccccc tttttgaaaa 1489381 tactgaaaac tttatattgt tatattaaac tagcattctg gaatactcaa caaaaactaa 1489441 cataactaga caaaattgat agtattgtcc tgtgtttgtt tttgttgaat aatatcaaga 1489501 tgagtcaagt gtcatgtggt ggttcattca agagttatgt tttttacata tcaaggggaa 1489561 gatgagatat ttttgtttca tcttgaaact ttttgaaaag tccgctgtct aaccgaatga 1489621 ggccttaata agaagtaaag gattgttgtt cgtgttggag ttattcagtc attatgtatt 1489681 gcatttcgaa cgttatttta tattaagcag acaaagcacc ctgctgattc aatggtcaat 1489741 tgttgttctg gcgggcttat atcttttggt gcatcatccc aaaataaacc ggcagcgcac 1489801 aatgttcttg gcgggtgtta tattgcggat tgtgctgctg gcgggagtgt ctgttgaact 1489861 tattcaccag gtgcaatcaa caaacttcac cagcgcttac ttaagagagg acggaaaaga 1489921 actgctgccg ctgctgcatt ttttgttata cggatatgtg ctgctgacgg cttttcacta 1489981 tatgctgatg ccgcgtgatc atggcggaaa gggtaagttt tatacgttcg accttgctgt 1490041 tgtcagtttg ccgatcgtac aaatgatttt tagtttcttt tcgtattgga aggaataccc 1490101 ggatgggatg gagccgattg cattcgtgtt tctgtttttc atcatcactc ttcccattgc 1490161 gttgaatgta gtgtttttca agctgtattg gagaacggat aagatcttac taggcttatt 1490221 ttatacgctg attatcggac tgcttgtctt gctgcttgcg ccatatccca atcaaatctc 1490281 aaaagattat ggtgcagtaa tgccatatac gatttatttg gcaatggcgg gatttttgat 1490341 gagctatcat ctgttccaaa agtcaggaaa ggtttatgtg cgtgtgaata agtgggtgac 1490401 gatggctgtc atggtgtttt ttgtcctgct gttaaatccg atatataaca taggaacggc 1490461 tgctttcgct gtatcaaagc cagcaaatgt ccatgattca ttcaattttg tcggggagca 1490521 catttcatca gaaaaagcgg aacagatact aaagtcattt tttcctacgg atgaaacact 1490581 ttatttgcac gatacaaaca tggatgtgca ttatttctac tcatttgaaa gcaaaggtta 1490641 caaagctgag gtagatgaag tatcgcagct aattcgtaat tatgaatact tacaaaaagc 1490701 acatgggaaa aagctaacga atcaggagta caagcgaaag tccatcgctt tccttgagcg 1490761 acacggacgt gtgttacata aggatcatat cgaaacaaag gtatctcaag aagacggcca 1490821 gacagtcgta cgtatttacc tgaaaaatca acttcataaa aaagatcatg ctgatgatgg 1490881 cgcggtattt tattgggaaa aggaaacctt aatggggttt agtgaagatc cttcgattta 1490941 tcagcttgac tctcttctgc atgttcatat aacggaacaa gacattcacg acaaagtgga 1491001 acaaatgttt acagcgctga acatatcaaa acagccttat cagatcactg atattgaaag 1491061 cgacagcctg cttggaagca tggtgagagt tgaaacaaaa gttggaattg ttttggaatt 1491121 tgagggcgaa tcaggttgtt tacatagtct ttcgcttccg atgaaaaaga atatctcaat 1491181 ggctaacagc cggctgcagc atcagatatt atcgatcttc gatgctcgtg gatcagaaaa 1491241 gaagaaaaaa agcagtcagg gtgacatggt gatgtatact gattcttcta aaacatatga 1491301 gtttgttgaa gctcaaggtc agctaaacgt ttatgtatac agcgatacac ctgatcagtc 1491361 attcccctat acgtatcgta atggaacatt ggcttacgaa aaagtagctt ctctatatca 1491421 ggatgtcatt tacaaaaagc gtatgcgtcc gattatcgtt caaagagggg atgaacggca 1491481 ttatgcatgg ctgatcatta ttcagccgtt tggttcaaat cgccatgatg cctatgtagt 1491541 ggatggagaa acacaagagg tgaaaagtct ttatgaatca taaagaaaaa gagtctgttt 1491601 ttgtagactt atacgacctg tataaagaag gagagctaga ggatgaatca atggaatgga 1491661 tgaaacagca tgaatcccta tttcaaaaga atgcggaaga cttaaagagt aaaacttgtt 1491721 taaagagaag tcccggtgct gaagaagaaa gccaaatcag atatatgaaa gtatacctgt 1491781 cttccatgta tatctgtttc attttattgg ccatttggat gacggtgtgg ttttattttt 1491841 aatgaagcat agggattcca ttgaggactt gtatcggcag tattatcaag aaattttaaa 1491901 ttatttattc agaaggactc atcatcttga aacagccaag gacttagcgc aggacacgtt 1491961 tgtaaaagct cttaacggtc tggcttcgtt tagggggcat tcttccatca gaacatggct 1492021 ctacaccatt gcgcatcata cctttatcaa ttggtaccga agggatgtca aataccaatt 1492081 tactgaaatc agcaaaaatg aagggttaac gcaaacaact tatgaccagc ctgaacagta 1492141 tctgtcacgg acggtgaaaa gcgaaacact gcggcaggag ctcctgaagt taaaagatca 1492201 gcatcaatcc gttttgattt taagagaatt ccaagagctt tcttatgaag aaatcgctga 1492261 gatattagga tggagtcttt ctaaggtgaa taccacattg caccgggcta gattagagct 1492321 aaagaaaaac atgacgaaaa gtagagagga ggagcggata tgacctgctt tctagtaaga 1492381 gacctgcttc ctctgtatct tgaaggtgat tgtaaaagag aaacggaaca cgttatagaa 1492441 gagcatttaa aaatgtgcag cagctgcaga gacatgtatg acacgatggc tgagccattt 1492501 gaattggaaa gcgaacaggc cgttgaggag gcttatctgc cggaagaaga actgcgtttt 1492561 aaacagaggt actatggatt actgatcatg aaagctgcct gctggtttgg agcggcggtt 1492621 gccatgatgc tgatcatcaa actgctgata taaaaaaagc gcttgtccga ttccggcaag 1492681 cgctttttta cattaagcct ggggatgaat catatcgtaa atagcggcaa gctgttcttg 1492741 tgacagggca ctgaagagtt tttcataaac gtcagcttgc agtggcgttg cacctgcttg 1492801 tagcgctgcg tctttatcat agctgtacac atcatcttgt agcacaatgg ctgcttgaag 1492861 aatgtgaatc ttgagagaaa cagcggagaa aaattgttca agtgcaagtg cttctttttc 1492921 tgtgaagcca agttcaactg ctttttctgt atcaaatttg taatttccat cctcgagata 1492981 cacacattgt gaaacaatgc tgaaaaattc tgatgtcgat tcccagagtg tagcaattac 1493041 ctgagcctct tcttttgtca ttcctaactc gacagctttt tcgctgtcaa aataatatac 1493101 accgtcttgt tcgtatatac attgatttaa tatatcaatg aatgtattga gatcttcgtt 1493161 agtgctcgcc tgatgctgga gttgaacagc agtgttatca accggtgttt ttgcgctggc 1493221 tgcatcagga ccgaacgtta atagagcagc tgaggtcatt gcggcagtcg ttaacatagc 1493281 tttttttaca aatgttttct tcatgtttct tctctccctt ttatgaattg tgctacaaat 1493341 tccattatag ggagtagttt ccggtggagg aataggcgct atggtatttt atgtgtatcg 1493401 ttgccgaact actttttgaa ggctgcacgt gtgatcgtta gaacgattgt ctatgtatga 1493461 aggctgtttt gcatcttcct gactaagaaa caggggagat aaggcttaaa gaaatgaaaa 1493521 acaccgcttt ctttgcggtg ttttttgatt acaatgtcgc cggcggggca atgcttttaa 1493581 tcaagcaagc cttgttcgcg cattttcttt tttaatgtaa atccgccgcc catgacagcg 1493641 caaacaagta caatgctggc gataatgcct gcagggcttt tttcagcgat aaagacgccg 1493701 atcagcataa tgctgaaaac cgctgcaaat gcaaataata gtaaaagcca attcattttt 1493761 ttcataaatt ccatcccctt ttacgtctta tattaagttt acagaaaaac gtgacgcttt 1493821 taaagaggat gtgtgatata atatgaaagt tatctaattt ttttaggaga tgaaaaagtg 1493881 aaacttcgaa atgatcttcg caacatcgcg attattgccc acgttgacca tgggaaaacg 1493941 actctagtcg atcagctttt acatcaggct ggtacgttcc gtgccaacga acaggttgct 1494001 gaacgcgcaa tggactctaa tgatcttgaa cgcgaacgcg gcattacaat attggcgaaa 1494061 aatactgcga ttaactataa agatacacgt atcaatattt tggacacccc tggacatgca 1494121 gactttgggg gagaagtaga acggattatg aaaatggttg acggcgtagt gcttgtcgtt 1494181 gacgcatatg aaggctgtat gcctcaaact cgttttgttc tgaaaaaagc tcttgagcaa 1494241 aacctgaacc ctgttgttgt tgtaaacaaa attgaccgtg actttgctcg tccagaggaa 1494301 gttatcgatg aagttctgga tctgttcatt gagcttgatg ccaatgaaga gcagctcgag 1494361 ttcccagtgg tatatgcttc cgcgattaat ggaacagcga gtcttgatcc gaaacaacag 1494421 gatgaaaaca tggaagcttt atatgaaacc attattaagc atgttccggc acctgttgat 1494481 aatgcagagg agccgcttca attccaagtt gcccttcttg actacaacga ctatgtaggc 1494541 cgtatcggaa tcggacgcgt attccgcggc acaatgaaag tcggacagca ggtttctctt 1494601 atgaagcttg acggaacggc aaagtcattc cgtgttacaa agatttttgg tttccaaggc 1494661 ttaaagcgtg tggaaattga agaagcaaaa gcgggagacc tcgttgcggt ttccgggatg 1494721 gaagatatca acgttggtga aacggtatgt cctgtagacc atcaagatcc gcttccggtc 1494781 cttcgcattg atgagccgac acttcaaatg acatttgtcg tgaataacag tccgtttgca 1494841 ggccgtgaag gcaaatatgt aacggcccgc aaaatcgaag agcgtcttca atcacagctt 1494901 cagacggatg tgagcttgcg tgttgagcca acagcttctc ctgatgcttg ggttgtttca 1494961 ggacgcggtg agctgcactt gtcaatttta attgaaaata tgcgtcgtga gggctatgag 1495021 cttcaagtgt caaaacctga agttattatc aaagaaatcg acggcgtacg ctgtgagcct 1495081 gttgaacgtg tgcaaattga tgttcctgaa gagcatactg gctctgtaat ggaatcaatg 1495141 ggtgcccgca aaggcgaaat ggttgatatg atcaacaacg gaaacggcca agtccgtctc 1495201 atctttacag ttccttcccg cggattgatc ggttactcta cagaattcct atcattaaca 1495261 cgcggattcg gtattttgaa ccatacgttt gacagctacc agccgatgca ggcaggccaa 1495321 gtcggcggac gccgtcaagg tgtacttgtg tcaatggaaa acggaaaagc aacatcatac 1495381 ggtattcaag gaattgaaga ccgcggtgtc atcttcgttg agccgggtac tgaagtatac 1495441 gaaggaatga tcgttggaga gcataaccgt gacaacgacc ttgttgttaa cgtcagcaaa 1495501 atgaaacagc aaacaaacgt ccgttctgcg acaaaggatc agacaactac aattaaaaaa 1495561 gcgcgcatca tgtctcttga ggagtctcta gagtacttaa acgaagatga atattgtgaa 1495621 gtaacacctg aatccatccg tttaagaaag aagatcctca ataagaacga acgtgaaaaa 1495681 gcagctaaaa agaaaaaaac agcaggattg tcttaatctc gtgcagaatt tgaaaagata 1495741 gaacccgtac gtttacaggg gagggaatct ttttgaatga cgtaagcgaa cgcctgtcgt 1495801 tcttcgccgc tctatatcaa gtagaccggc agcctgcggc aggcatgtgg ctgctgtacg 1495861 gcacgatttt tgtgttggcc gttattgtat ttaagcttgg atttgctaaa cggcttcctg 1495921 tattaaaatc tgcagtggtg tatgtatttt tggctttggg ctgcactgtt ttgacttttt 1495981 taggggtgtt tttgcccgtg gcagaaggat tggtcgtcgc tgcgctgatt ttaatcattt 1496041 acaaaatccg gctgtatcag tcgaaaaaag gacagtctgc aaaatcataa aagactcagc 1496101 tgaaagctga gtcttttttg tgttctgtat ggttaagcgg ccgctttatt ttttgacttt 1496161 ttcttttttc tgctgtcccg ggtgaaaagt aaattttccc gttttcagcc gttcctctgt 1496221 ttttttggca atccgatcgt ggcattcctg gcacatatat gtatggatcg ggcggtttcg 1496281 aagccgtttc gcgatcaggg tatcatcatc aattgtttca attttatcgc aaatagaaca 1496341 tttgaccctc atcatatcac ctctttcact aacatgtatt ataccacgga tcagaagctg 1496401 tccaaaataa gaaaaagcta aagcgcaagg ctatagctta gtcattgttg ttctttttca 1496461 tatgatgatc agattgatcg ttttgttcct tctccatttc ctgttgctgt tttctattta 1496521 attggtcatt ttgctgcttt gtttgcggtt catcttcatt gtcaatcaca tcgttaggca 1496581 cttcgggaag cactcggccg acaattgcag ctaattcatc cagtatacct gttaccggat 1496641 ggccctcgct gatttctctg ctcatttcgc gaaggcggct gaccgtatcg ggatcagcaa 1496701 tgactactgc gttggcgcca tatcgatcat tctttagcgc ctgagctaca gaatatttaa 1496761 tggtttccac tttgcttctg tccaaagtat catcgacatc aatcccaaca acagcatagc 1496821 ctcccagcac aacggctgtt gcatccttga cgtcggggtt tttttcagca acgctgacaa 1496881 gatgcttggc aatatccgtt cttgttccat tgtcttttgt ttcttgagtt gtgtccttta 1496941 cgtgaatcgg tttagtctcc tgctgtcttg ttgattcttt ttcaacattc tggccctgtt 1497001 ttccttgttg ataggcacaa gcggacagga taagtgtcag ctgtatgata atgaaaagaa 1497061 ttcgcacttg cgggttccct ccttaaaatg ctttcattaa ttttattgtt gaattaacct 1497121 tctatcttta tgcacaaaaa catatatttt agcaggcatt cacctttttc atcaaaagag 1497181 aagcaggaag aactttgacc cttatatcag gaggctgaga cttgagtaaa atttatgtgt 1497241 tagatacgaa tgtgttatta caggatccta acgcgatatt ttcttttgaa gaaaatgagg 1497301 ttgtcatccc tgctgtcgtt ttagaagagg ttgattcaaa aaaacggtat atggacgaag 1497361 ttgggaggaa tgcaaggcac gtatctaagc taatcgatgc gctaagacaa aagggcaggc 1497421 tgcatgagca tgtaccgctt gacaccggcg gcacactgag aattgaactg aatcatcgtt 1497481 cgtttcacca gctgcaagag atctttattg aaaagacgaa cgataatcgc atattagccg 1497541 ttgcgaaaaa cttaagcctc gaggaagaaa ccaaggaaaa tggcaggccg gttatccttg 1497601 tcagtaagga tgtactggtc agggttaaag ccgacgcaat cggactgctt gctgaagatt 1497661 tcttgaatga ccgggttgtg gacaatgatg aaatgtacag cggctataaa gatttatata 1497721 tcagccagca gctgttcagc tctttttacg ggaaaaatca aatttcagta aacgatgtga 1497781 aacagcatgc gttttatccg aatcagtttg ctttaatgaa ggatgagcta ggagggtcct 1497841 cctcggcagt cggaattgca gacaaaaccg gaacggtatt aaaaagactc gtatttgatg 1497901 atgaacatat atggggaatc aggccgaaaa atgtacagca gacaatggca ttagagcttt 1497961 tgctgcggga agatattccg cttgtcaccc tgatcggcaa agcgggaacc ggcaaaacgc 1498021 tcttagcttt ggcggcaggg ctattacaga cagaagactt gggaatatat aaaaagctgg 1498081 tcgtcgcaag gccgattgtt cctgttggca aggacatcgg gtatttgcca ggcgaaaaag 1498141 aggaaaagct aaagccttgg atgcagccga tttttgacaa cttagagttt ctgtttaatg 1498201 cgaaaaaacc aggggagctt gatgctattt tggcgggaat tggctcaatt caggtagagg 1498261 cgctgactta tatcagaggg agaagcattc cagatcaatt tattatcatt gatgaagcgc 1498321 aaaatttgac caggcatgag gtgaaaacgt tgctgacgag agtcggtgag ggcagtaaaa 1498381 ttgtcttaat gggcgaccct gaacaaattg atcacccata tttagacagt ctgaacaatg 1498441 gtttggccta tgtggttgag cggtttaaag gacaacccat ctcaggcagc gtgaagctgt 1498501 taaaaggtga gagatcaggt ctcgcccagc ttgcagctga tttgctgtaa cacttaaatg 1498561 atttcgatct cttttacatc ggtaatcggc tgtttgtgat gaaccgggtc ttcaaagtaa 1498621 atatgcacgg ggccgccttc ttgaatcggc ttgcctgcct cactgaaatg gacaatactg 1498681 ttcagagcgg tttccagaga aacggcggcc tttcccgaac ttgtgacaaa tacacattgt 1498741 gtcgcagagc tgttcggctc agcatttttc aggacagtcc caagtctcat tgcgaaactg 1498801 ccgttcatca gtttttgctt ctcatattgc ttttccgtct ttaatgtagg cggcgcgatt 1498861 cgcccctctc tgatgacgcg ttccggatca aggtcggatt catccccggc tgattgtaaa 1498921 tatgtgtctt gactgtcccc tttgcggtca aacgaaaatt tgcgatcatc aaaaatccat 1498981 acgcttggat caatggtaat tggatatgta acattgcctt ttacttggat aacgctcatg 1499041 atatgacccc cttctctcaa aattataaaa gttttcgcat gaattgtcac tttgtgtaca 1499101 aattatgtgt attgaaatgc tgagggaacg agggtgtttg catggtatgc cagcataatg 1499161 atgagcttga agccttagtg aaaaaggcga aaaaagtaac ggacaagggg gaggtagcca 1499221 gctatattcc cgccttggca aaagctgata aacacgacct gtcagtggcg atttattatt 1499281 ccaataatgt ttgtctgtca gcaggtgacg tagaaaaaac atttacgctt caaagtatat 1499341 cgaaagtcct ttcccttgct ttggtgttaa tggaatacgg caaagataag gtcttcagtt 1499401 atgttggaca ggagccgacc ggtgatccgt ttaattcaat tatcaagctc gaaacagtga 1499461 atccgagcaa gccgttaaac cctatgatta atgccggggc attggtagtg acaagtctga 1499521 taaggggaag aacggtaaaa gagagacttg attatttgct ttcttttatc agaaggctga 1499581 caaacaacca agagattaca tactgccggg aagtggctga atctgaatac agcacttcaa 1499641 tgattaatcg ggcgatgtgt tattatatga agcagtacgg catttttgaa gatgatgtag 1499701 aggcagtaat ggatttatat acgaagcaat gcgcgattga gatgaacagc ttggatttag 1499761 cgaaaatcgg atctgtattc gcattgaacg gcagacatcc agagactggg gagcaggtca 1499821 tctcaaaaga tgtcgctaga atttgcaaaa cgtttatggt gacgtgcgga atgtacaatg 1499881 caagcgggga attcgcaatt aaggtcggaa ttcctgcgaa aagcggcgta tccggcggga 1499941 taatgggcat ttcgccttac gatttcggga tcggcatatt cggccccgca ttagacgaaa 1500001 aagggaacag cattgcaggt gtaaagcttt tggaaataat gtctgagatg tacaggctga 1500061 gtatttttta atttatgtca tatgcttaaa tcctcttgca ttttctgttg atacccttta 1500121 tgataaatag aagaattagg tactcgcctg gggaacggag ggatactttt ggcttcagag 1500181 atgatagttg accatcggca aaaagctttt gaactcttaa aagtggacgc tgagaagatt 1500241 ttgaagctga tccgagtaca aatggataac ttaacgatgc ctcaatgtcc tctatatgaa 1500301 gaggttttag atactcaaat gttcgggctt tcgagggaaa tcgattttgc tgtccgcctg 1500361 ggattggttg atgaaaaaga cggtaaagac cttttataca cattggagcg cgaattgtct 1500421 gctttgcatg acgcgtttac agctaaataa atgataaaac tcaaacttat taacagtttg 1500481 ggttttttta taaccgctat ttttctctca tctcataaaa gacggtcttt ttttacacat 1500541 tccttccgaa tcgtatagag attcttcgtc tcgtttgata aattgtagta aaataaaaaa 1500601 gataaataca taaaaaccat agataatgga agttagaagc agggaagagg atgttatgtt 1500661 aaaaaaaatg ctaaaatctt atgattactc actgatattc gcaatcgttt tattatgcgg 1500721 attcggttta gtgatggtat acagctcaag catgattacg gctgtctccc ggtatggagt 1500781 aagcagtaat tttttcttca tgcggcagct gtttgcttta attgcgggtg gcgctctatt 1500841 tattctcatg gcgttgtttc cttataaagc actggcccat caaaagtttc agaaggggat 1500901 actgcttgta tctgttcttg cgcttatctc actgtttgtt ttcgggcatg ttgccggaaa 1500961 cgcgcagagc tggtttaaaa tcggcggaat gagtattcag ccgggggagt ttgtgaaact 1501021 ggtcgtgatt ttataccttg cagccgtata tgcaaaaaaa caaagttata tcgaccatct 1501081 gttaacggga gtagcccctc cggtagtcat gacgcttata atttgtgggt taattgccat 1501141 gcagccagat ttcggtacag ccatgattat agggttaatt gcgacgtgca tgatcttgtg 1501201 ctccggcttc agcggaaaga cgctggtgag gcttgtgata ctgggcggaa ttgttttcat 1501261 tttagtcagc cctattatct atttgaatca ggacaaaatt ttaactgaag gccgtttagc 1501321 gcgttttgag agtcttgaag acccatttaa gtatgcaaat tcatcaggtt tgcaagtgat 1501381 caattcttat tatgcgatca gctcaggcgg cattttcggc ctggggctcg gtgaaagtat 1501441 ccaaaaatac ggatatctgc ctgaatcaca cactgacttt attatggctg tcattgctga 1501501 agagctcggc atttttgggg tattgtttgt gattttctta ttgggttttg tcgtcataaa 1501561 aggtttttat attgccagaa aatgcgagga cccgtttgga agtcttctgg cgatcggcat 1501621 ttcaagcatg attgccatcc agtcgtttat taaccttggc ggtgtcagcg gattaattcc 1501681 gattacaggg gttacgctgc catttatcag ttacgggggc tcttctttgg tgctgctgct 1501741 ggggagtatg gggatattag cgaatatcag catgtttgtg aaatattcag agaataagaa 1501801 aaagaaagag cccttggcgc cgaagggaat gaaaaagaaa cagctcaaaa aaactgttta 1501861 tctgtaaaaa acaagtgtgt acaggggaag gatattccgc tatgatagat tatattccat 1501921 tcgggtaagg gggagaaaag tttgtctcag caatcgatac aaaaagtatt agtagcaaac 1501981 aggggagaaa ttgcaatccg aatattccgg gcgtgtaccg agttgaatat tcgtacagtt 1502041 gcggtctatt caaaagaaga ttccggttcc taccatcggt acaaagcgga tgaagcatac 1502101 ttggtcggtg aagggaaaaa accgattgat gcttacctgg atattgaagg tatcattgat 1502161 attgcgaaaa gaaacaaagt cgatgcaatt catccgggat acggtttctt atctgaaaat 1502221 attcattttg cgagacgatg tgaagaagaa ggcatcgtat tcatagggcc aaaatccgag 1502281 catctcgata tgtttggtga caaggtaaaa gcgcgtgagc aggcagaaaa agcgggaatc 1502341 cccgtgattc cgggaagcga cggtcctgcc gaaacgcttg aagccgtcga acaatttgga 1502401 caagctaacg gttatccgat catcattaaa gcctcgcttg gcggcggcgg ccgcggtatg 1502461 cggattgtca gatctgaaag tgaagttaaa gaagcatatg agcgtgctaa atcagaggcg 1502521 aaagcagcct ttggcaatga tgaagtttat gtagaaaaat taattgagaa tccgaaacat 1502581 attgaggttc aggtcattgg agacaagcag ggcaatgtcg tccatctttt tgagagggat 1502641 tgctccgttc aaagacgcca tcaaaaagtc attgaagtgg cgccgagtgt ctcgctgtca 1502701 cctgaattaa gggaccaaat ttgtgaggct gcagttgcgc ttgccaaaaa tgtaaactat 1502761 ataaatgcgg ggacggtcga attccttgtt gcaaacaacg agttctactt tattgaagta 1502821 aatcctcgcg tacaagttga acacacgata acagaaatga ttactggtgt cgatattgtt 1502881 caaactcaga tccttgttgc ccaagggcac agccttcaca gcaaaaaagt aaatattcct 1502941 gagcaaaagg acatttttac aatcggctat gccattcagt cacgggttac gactgaggat 1503001 ccgcaaaatg atttcatgcc tgatacagga aaaatcatgg cttaccgctc aggcggcggt 1503061 tttggtgtcc gtcttgatac cggaaacagc ttccagggcg ccgtgatcac accatactat 1503121 gattcacttc tcgttaagct ttcaacttgg gctttaacgt ttgaacaggc agctgccaaa 1503181 atggtgcgaa accttcagga gtttagaatc agaggcataa aaacgaacat tccgttcctt 1503241 gagaacgttg caaagcatga gaagttcctg acagggcaat atgatacatc tttcattgat 1503301 acaacgcctg aattatttaa tttccctaaa caaaaagacc gcggaacgaa aatgctcact 1503361 tacatcggca atgtgacagt gaacggcttc cctggaatcg ggaaaaaaga aaaaccggcg 1503421 tttgacaaac cgttaggcgt aaaggtagac gttgatcagc agcctgccag aggaacaaag 1503481 caaattctcg atgaaaaagg tgcagaaggg cttgcaaatt gggttaagga gcagaaatct 1503541 gtccttttaa ctgatacgac attcagggat gcccaccaat cgttattggc aactagaatc 1503601 agatcgcatg atttgaaaaa aatcgcaaat ccgacggctg cgttatggcc tgaactattc 1503661 agtatggaaa tgtggggagg cgcgaccttc gatgtagcct accgattcct gaaagaagat 1503721 ccgtggaaac gtttggaaga tcttcgcaaa gaagtgccga ataccttatt ccagatgttg 1503781 cttcgctcat caaatgcggt cggctatacg aattatccgg acaatgtgat taaagaattt 1503841 gtgaagcaat cagctcaatc cggtattgat gtgtttcgta ttttcgacag cttaaactgg 1503901 gtaaaaggga tgacgttagc cattgatgct gttagggata ccggcaaagt ggcagaagct 1503961 gcgatttgtt atacgggaga tatccttgac aagaaccgga cgaagtacga ccttgcatat 1504021 tatacatcga tggcgaagga gcttgaggcg gccggagccc atattctcgg gattaaagat 1504081 atggcagggc tgttaaaacc gcaggctgca tatgagctcg tttctgcgtt gaaagaaacg 1504141 atcgacattc cggttcacct tcatacgcat gatacgagcg gaaacggtat ttatatgtat 1504201 gcgaaagctg ttgaagccgg cgttgatatc atagacgtgg cggtcagctc aatggcggga 1504261 ttaacgtcac agcctagcgc gagcggattt tatcatgcga tggaaggcaa cgaccgccgt 1504321 ccggaaatga atgtccaagg cgttgaattg ctgtcccaat attgggagtc ggtgcgtaaa 1504381 tattatagtg aatttgaaag cggaatgaag tctccgcata ctgaaattta tgaacacgaa 1504441 atgccagggg gccaatacag caacctgcag cagcaagcca agggagtagg ccttggcgac 1504501 cgctggaacg aagtcaagga aatgtacaga cgcgtgaacg atatgttcgg tgacatcgtc 1504561 aaggtaacgc cttcctcaaa agtagtcgga gatatggcac tctacatggt gcaaaacaat 1504621 ctgactgaaa aagacgttta cgaaaaaggt gaatctttag atttccctga ttctgtcgtg 1504681 gagcttttta aaggaaatat cggccagcct catggcggat tcccagaaaa actgcaaaag 1504741 ctgatcttaa aagggcagga gccgattaca gtcagaccgg gcgaactgct tgagccggtg 1504801 tcatttgaag cgatcaaaca ggaatttaaa gagcagcata acttggaaat ttcagatcag 1504861 gatgctgtgg catatgccct ttatcctaaa gtcttcactg attatgtgaa aacgacagaa 1504921 agctatggag acatctcggt attagataca ccgacattct tctacggtat gacattaggt 1504981 gaagagatag aagttgaaat tgagcgcggc aaaacgctga tcgttaagct gatttcaatc 1505041 ggtgagcctc agcctgatgc cacccgcgtc gtttatttcg aactcaacgg gcagccgcgt 1505101 gaagtagtca ttaaagatga aagcattaag tcttccgttc aggaaaggct gaaagcagac 1505161 cggacaaatc caagccacat cgcagcttcc atgcctggaa cagttattaa ggtattggct 1505221 gaagcaggca caaaagtcaa taaaggtgat catttgatga ttaatgaagc gatgaaaatg 1505281 gaaacaacgg ttcaggcgcc tttctcagga acaatcaagc aggttcatgt gaaaaatggt 1505341 gagccgatcc aaacgggaga tctgctcctt gaaattgaaa aagcataaaa aacaaagagt 1505401 gtatatcaat gatatacact cttgtttttt atatagaaaa tgtggagtga aacagatggt 1505461 tagaagagat ataaggggac ttcagagatt atagagtact gtcacaagcc caaaataaaa 1505521 agaggcttat acagccaata ttttagatgc tttgtagtat gccgtgcata tttctttaag 1505581 cactatctga tttaaaaggc tttaatactt atgttcgcga gctatagatc catatgaaat 1505641 ttctataatc acgatgagaa aggggacaga ccgaagtgag ccgctcactg atcatcaagt 1505701 tcggcgaagg ctggcgattg aaacgcataa agcgccaaaa aacaagacat aaaaaagacc 1505761 aaagccgcct aaggctttgg tcttgagtcc ttatgattgc ctggattcat aacggaaacg 1505821 agcaatcaat aataagaagt agcatagaac gccaaacaga caggcaataa agaacgagtg 1505881 ggcaagtgca aagcccagag ccagttcaga gtatacgatc ataataccgg acagtgcctg 1505941 taatgtaatg aaaataagac atgagatcca tccccaaaag atctgttttt gatctttata 1506001 ggaagtaata gcatgaacag cggcaacaat aatccataca aataaaagta aggctgctgc 1506061 tctgtggccc atttgcaccc attcatggaa ttgggtcgga agtccattgt tcagcgggct 1506121 gcacagcggc acattaggac atgccagact tgattcagtg tgtcttacat atgcgcctgt 1506181 atacacaacg atataggaat atattaaaat tcctatcatg tgaaattgca tctttttgcc 1506241 gatttgaagc ggcttaacca gtgttctgac tgatttatca gcttcaaata tgagcaatgt 1506301 taaaataagc actgaagcaa aagaaattaa tgagatgccg aagtgaagcg ccataatcag 1506361 cgcgttcgaa ccgaatacga cagccaatgc gccaagcaat gcctgaagaa ataaaaagat 1506421 aattgacatg atcgcgagaa acgttgtttc acgaaaaatc ggcgtgattt ttctccatga 1506481 ccaaaacgca aggcttagca caaggataat agagattccg cttgcgaatc ggtggctcca 1506541 ttcaataatt gaagccggat tcagttcagg gaaaaaacgg ccgtgacaca gcggccactg 1506601 tctgccgcat ccttggccgg aacctgtttt tgtaacgagg gcacccccga ttaaaacaat 1506661 tagcatgaca aatgtcgtca gaacaccgag agcttttaat gctttattca tacaatattc 1506721 accttcttaa catactgctg caattttata tacgttccaa gtgtaagcga atatgtgttt 1506781 tgtggcaatt cccagagcct tttgttcaca aaaatataat agaatgacgg cttctggaaa 1506841 atgtacactt gattattcat gccgggtctg atagaaataa ggtaaacgca atgccgattt 1506901 ggagattgcc ttcatctttg gtaaaattca taaaaagttc acaaataaat tcctgtttgt 1506961 cgtttaatat ttaataggat gtttttttac aagatgttat cttgtatgat agagttgcag 1507021 gttattttat tctcctgcgt taggtttgta agggaggttt acgttatggc taactccaga 1507081 atcttaaatg atacagctat agacggacaa attgaagaaa caacggcatg gaaagatttt 1507141 ctgtccctta ttaaaatagg gatcgtcaat tctaacctca tcacgacttt cactggaatg 1507201 tggcttgcac tgcatatatc cggtttaagt tttttaggca atataaacac cgttcttctt 1507261 acgttaatcg ggtcttcact gattattgcg ggctcctgcg cgatcaataa ctggtatgac 1507321 cgggacattg accatcttat ggagcgtacg aaagtaagac cgacggttac gggtaaaatt 1507381 cagccgagtc aggcgttatg gtctggaatt ttgctggttg ctttaggatt gatcatgctg 1507441 ctgatgacaa ctgtcatggc tgctgttatc ggttttatcg gagtctttac gtatgttgta 1507501 ttgtacacaa tgtggacgaa acgccgctat acgattaaca cagtagtagg aagcgtttcc 1507561 ggtgcagtgc cgccgcttat tggatggacg gcagtggaag ggaatatcgg tgtcgtagca 1507621 tgggtgttat tcatgatttt atttatttgg cagattcctc acttcttagc attggctatt 1507681 aagaaaactg aggattacag agctgcaaat attccgatgc ttcctgtcgt atacggattt 1507741 gaagtgacaa aaagacaaat tattgtgtgg gttgcgtgcc tgatgccgct tccgtttttc 1507801 cttggtagcc tgggtcttcc gattgtcatt ctcggcttgc tgttaaatat cggctggctg 1507861 attcttggct taatgggatt ccgctccaag aatatcatga agtgggcaac gcagatgttc 1507921 gtttactcgc ttaactacat gacaatctat ttcgttgcca tggttgtctt gacgcttttc 1507981 taaaaaatag atatgatgct tgttttatcg cttcaaaata aacgatgaca actagtaaat 1508041 gccgccttga cctcttgttt aatcaggcgg ctttactttt atacatagat ggcattttga 1508101 gtaaaaaaac tcataattta agagaagagg aaatgtaagt gctttattgg tgataggttg 1508161 gatggcgata gatttcgatc cgctttccgc ctttgtattg accagaaaag gggttgggtg 1508221 aaatggtaaa gcattggcgt cttattttat tattagcctt agtgccgctt ctattaagcg 1508281 gatgtggaaa acctttttta tccacgctca agcctgctgg cgaggtggct gataaacagt 1508341 atgacctgac agtgctcagc acattgatta tggtggttgt tgttgcagta gtatctgtta 1508401 tcttctttta tgtgattgtg agattcagaa gatcacgggt cggtgagaac acgataccga 1508461 aacaggtaga ggggaataaa tttttagaaa tcacatggac cgtgatcccg attttgctgc 1508521 tcattattct tgtgattcct gttgtattat atacgctgga gctagcggac acatcaccaa 1508581 tggataaaaa aggccgcaaa gctgaggatg ctcttgtagt caatgttagg gcaaatttat 1508641 actggtggga gtttgagtac cctgattacg gcattatcac aagccaggag ctgattgtac 1508701 cgacagatca gcgtgtatat tttaatttaa aagcctctga tgtaaaacat tccttctgga 1508761 ttccttcagt tggaggaaaa cttgatacga atacggataa tgaaaataag ttcttcctga 1508821 catttgattc aaaacgaagc aaagaggcag gagatatgtt ttttgggaag tgtgcagagc 1508881 tttgcggccc ttcacatgcg ctgatggatt ttaaggtgaa gacgatgtct gcaaaagaat 1508941 ttcagggctg gacaaaagaa atgaagaact ataagtctac agcagagagc gatttggcta 1509001 agcagggtga agaactgttt aaagagaaaa actgcctgag ctgccatgcg gtagagccga 1509061 atgataagcg tgcagaagcc gctagaacgg cacctaactt ggcgaccttc ggtgaaagga 1509121 caaaagtggc aggggtgaaa gaggccaaca aagaaaatgt gaaggcttgg ctgaaggacc 1509181 ctgacagcat aaagccgggg aacaaaatga caggcacata tccaaagctc tcagacagcg 1509241 aaacaaatgc gctttatgaa tacttaaaag gcttaaaagc ggaaagcaag tagggaagaa 1509301 agggagatat tgggggaggt cacatatgtt gaatgcgctt acagaaaagc ggacgcgcgg 1509361 atctatgctt tgggattatt tgacgacggt ggaccataaa aaaatcgcaa ttctttattt 1509421 agtggcaggg ggattcttct ttcttgtcgg gggaattgaa gcgatgttta tcagaattca 1509481 gcttgcaaag ccggaaaatg cgtttctcag tgctcaagcg tacaatgaag taatgactat 1509541 gcacggaacg acgatgatct ttctggctgc gatgccgctc ttatttgcct tgatgaatgc 1509601 ggttgtgcct ttgcagatcg gggctcggga cgtttcgttt ccatttttaa acgcgcttgg 1509661 tttttggctc ttctttttcg ggggcatttt cttaaatcta agctggtttt tgggcggagc 1509721 gccagatgcg ggctggacat catatgcctc actttcgctt cattctaaag ggcacggcat 1509781 agactttttc gtcctcggac tccaaatatc ggggctcggg acgctgatag ccgggattaa 1509841 ctttttggcc acgattatca acatgagggc tccgggcatg acgtatatga ggctgccttt 1509901 gtttacatgg acgacatttg tggcctcggc attgattttg ttcgcgtttc cgccgcttac 1509961 ggttggattg gctctcatga tgctggatcg gctgttcgga accaatttct ttaatccgga 1510021 gcttggcgga aatacggtca tttgggaaca tttattttgg atcttcggcc acccggaggt 1510081 ttatatccta attttgcctg cattcggtat tttttctgag gtcatccctg tgttcgccag 1510141 aaagcgtttg tttggctatt cttcaatggt ttttgcaatc gtgctcattg gctttctggg 1510201 ctttatggtt tgggtgcacc acatgttcac gactggtctc ggcccgattg caaatgcgat 1510261 ttttgcggtt gcaacaatgg ctatcgcgat tccgaccggg attaagattt ttaactggct 1510321 gttgacgatt tggggaggaa atgtgaagta tacaaccgct atgctgtatg ctgtctcatt 1510381 tattccatcc tttgtgctcg gcggtgtgac gggagtcatg ctggcagctg ctgcggctga 1510441 ttatcagttt catgatacgt attttgtggt tgcgcacttc cactacgtca ttattggcgg 1510501 cgttgtattc ggccttttag ccggtgttca tttctggtgg ccgaaaatgt tcggtaaaat 1510561 tctgcatgaa acgatgggga aaatttcatt tgtattgttt tttatcggct ttcacctcac 1510621 gtttttcatt cagcattttg tcggcttaat ggggatgccg cgccgggttt atacgttttt 1510681 gccaggacag ggtctggaaa ccggcaactt gatcagtaca atcggggcgt tttttatggc 1510741 ggcagctgtt attcttctgc tggtcaatgt catatggaca tcggtaaaag gtgaatatgt 1510801 aggtgctgat ccatggcatg acggacgtac gctggaatgg accgtttctt caccgccgcc 1510861 ggagtataac tttaaacagc ttccttttgt cagaggactt gatccgcttt ggatcgagaa 1510921 gcaggcaggg cacaaatcaa tgacgccggc ggaaccggtt gatgatattc atatgccaaa 1510981 cggctcaatc ctgccgctca tcatttcctt cggccttttt gtcgcagcgt tcgggctgct 1511041 gtacagaagt gattacgctt ggggcctgcc ggtgatcttt atcgggctcg gcatcacatt 1511101 tattacgatg ctgcttcgtt cagtaattga tgatcacggc tatcatattc ataaagagga 1511161 actgccgaac gatgataaag gggtgaaggc ataatgcaag ttcaagaaaa attcaccgca 1511221 gaaacctttc cagcttctcc tgaaaaagta accctggaag ggaaaaataa atttttaggc 1511281 ttttggcttt ttcttggcgg agagactgtt ctgtttgcgt ctctcttcgc cacgtttctt 1511341 gcgcttcgga attcaaatgc cggtgatccg cctacgacgg aaatgttcga tgtgacactt 1511401 gtattcattg ccacaatgct tctattaacg agcagtttaa cgagtgtgta cgcgatgtac 1511461 cacatgaaga acttttcctt cggcaagatg cagctttggc tgggaattac gattttattg 1511521 ggggcgggct ttttaggact ggaaatctat gagttcaagc attacaccca tgaatttggc 1511581 tttaccatca caagctctgc ccttggttct gcgttttaca cgcttgtcgg tacacacggc 1511641 gcccacgtgg catttgggct tatgtggatc agcacgctta tgatccgcaa tgccaagaga 1511701 gggctgaatc tgtatacggc gcctaagttt tacgttgcca gcctttattg gcactttatt 1511761 gatgtcgtgt gggtcttcat ctttaccgtt gtatatttaa tggggatggt gggataaaca 1511821 tggtcgataa aaaaagcaga gggcatatca atagcgacct tgaatttaag aaaaaaaagc 1511881 atgcccggga gatgaaatat caagtcctgt cttttggttt aatgatcggt cttacgattg 1511941 ttgcatttct gactgtggcc acggacggtg tcggcagctg gtttacgatt cctttcatta 1512001 ttttgctagc tgcaattcaa gtcatttttc agctgtatta tttcatgcat atgaatcaga 1512061 aagggcatga ggcgccggca ctgtttttgt attcaggggt gtttgtcgcg tttatcactg 1512121 tgcttgcgtt tgtgacaatt atatggtggt aatttgaaca gccgccggag gtgaagaaat 1512181 gaatcagttg gagatatttg ggtttcgcgc gatgtggagc ccttatcttt tttgtatcct 1512241 gttaggcatt acggcgcttt atctctattt ttacaggcga atgtcttcaa agccgaatcg 1512301 aataactggt aaagagatgg tgtgctttct gtcggcgatg ctgtttttat atgcagccga 1512361 gggaagcccg gttgatctgc tcggacatat tatgttcagt gcgcatatgg tgcagatggc 1512421 cgtcctgtat ttggttgtcc cgccgctgtt aatcgcgggg attcctgcat ggctctggga 1512481 aaaaatcatt ttcaggcctt caatcaaacc ggttttttcc ttttttacga cgcctttaat 1512541 tgctttgctt ttgtttaacg gcattttttc tttatatcat gtaccgctta tatttgatac 1512601 tgtcaaaaca gatccgtttt accatacatt aatcacttgg cttatctttg tgcttgcgtt 1512661 cttcatgtgg tggccgcttg ttcataaggt tgagcgtcta cggcagctca gcggcttgat 1512721 gaagctgggt tatattatgg cggacggtat gctgctcaca cctgcttgcg ccttgatcat 1512781 gttcagcggt gcaccgttat acgccaccta tacagatccg gctttatggg ctgaggcaat 1512841 gaggctttgc gtgccagcgg atatgatggg gcaggtccca ttaacagggc cagagatgtt 1512901 gaatacactg cctttgttag aggatcagca gctcggagca gtcatgatga aaatcattca 1512961 ggaaattgtg tacggtactt ttttggccgt tatttttttc caatgggtga agaaagaaag 1513021 ggaaaaggac gggcaggagg agccgccgta tattcagcag acgatatcat aaaaggtaca 1513081 gcgaaatatg ctgtaccttt tcgttacatt tgaactgttt ttaacatgtt ggctatgtcc 1513141 tgaatcagtg ccttgctttt tgtcacaacc tgtacgggaa actcttccgt ttctccatat 1513201 tctactccat gagggtagta atgctttcct aggagagggg acattaattg aatcacggcg 1513261 cgcccgcttc cgacatcgcc ttctgccgca ataccttgta tccgcaggta aaacgtaccc 1513321 tcaatcgtcg aaaacttctt gtcataggtg actctctcgt aatcccattg acccgctctg 1513381 ataagacctt tgctttccat taagtcgtct agccagctga gctcagcctt aaccccttca 1513441 agtccgcttt cagtaaactt caacactgac ccctccttat aaaaattacc tttcctgaca 1513501 atcatagtat gaaagcgtta aactttcaat gaatcttctt cttttgaaag tatgcaaaaa 1513561 ttaaattttg acgacaatag cactagacta aaggaggtta aacggatgac aaaaataaaa 1513621 gatctgatga cagccgactt gcaatattgc acggtattag ataatgtata tgaagctgca 1513681 gtaaagatga aggacgcaaa tgtaggagcg ataccggtag ttgatgagga cggggaaaca 1513741 ttggtcggca tcgtaaccga ccgcgatctc gtattaagag gaatcgccat caaaaaaccg 1513801 aactcgcaaa aaatcactga cgcgatgact gaaaaacctg tcagtgtgga ggaagatgct 1513861 tcagtcgatg aggttcttca tttgatggca tcgcatcagc tcagaaggat accagttaca 1513921 aaaaataaaa aactgactgg aattgtcacg cttggtgatc tttctttatc tgagcaaacg 1513981 aatgaacgtg ccggcagcgc cttatcggat atttccgaag gggataatag agaagaaggc 1514041 ttttttcatt aacacataaa tctttgacat gttaaatagg ctgtattgta atgggatgta 1514101 aacaagagat tgtgaatcgc cacgggggtg atagattgaa aaatatattg agagcaatgg 1514161 ttatcctttt gattatctgc ggaacctatg ttctgtttat tcaatatgga tctgttcctg 1514221 aaaagaaatc aaatgacagc gagcctcagg tgtcgaatga ggaagcgcaa agcggcaaac 1514281 gaatacatat gccgacttca gggttattgt ccttcatggg caagcacgcc gatgaagtaa 1514341 cgaaaaagct tggggaacct gaacgtattg acccttcggc ttatgattac gattggtggg 1514401 tatacaatca aggtaaggat caatatatcc aaatcggggt attaaacaat aaagtggtca 1514461 cattattcgc gtcgggtaat gatattaacg ccaagccttt caaaattgga gaatcaactg 1514521 gcgaagtatt caagaccacc caggtggcac catttgtgaa tgtagagtat aaaggaaatt 1514581 cctatcggtt tgaattttct gaagaagata tcaatacaag accgactgta aaggtaggaa 1514641 agatgtatgt ccagctgtat atggacaaat ttgaggggaa gctatccagc atcagggcgt 1514701 ttgatgcgca gacctttgta aagcaaagac cttatgaggt agtgtaccgc ggggaattaa 1514761 ttaaaccgaa agccgtttca gatgagaaat ggaaaaagat ccaaacaacg agcgaaaagc 1514821 aaatccttga tttgacgaat gtcatacgcg ttaaacatgg acttgcgaag cttgagtggg 1514881 atcagccaac ggcggaagtg gcatttgggc atagtgagga tatgaaggaa aataattatt 1514941 tctcccatgt ctctaaaaaa tacggctcgc tgaaagaccg cttagaagaa gggcatgttg 1515001 attttcagca agcgggagaa aatatcgcat acaattatgt ggacggtccg gctgctgtag 1515061 aaggctggct gaatagcgaa ggccatcgaa aagcgcttct gaattcagat tatacgcatc 1515121 ttggtgtcgg agtagaccgg aaatattaca cccaaaactt tattaagcga tggtaatgaa 1515181 agccgcggac gaatggttcc cggctttttc tatttccata caagctggtc tgaatgaatg 1515241 tgctgatagc ttacagataa ggccgtttcc catcccttca gtcaggcttt ttcaccagtg 1515301 tatagggata tcgctaaaaa ttcatttggg aatgaatata ggcgaacaca atgcccgaca 1515361 aaacgataca ttgtagtagg taacgatttt cggagggggt gaggattgtg gcgaatcaac 1515421 atgccaatca ttcaatcaat gactttaaac aattcgtcaa aaagcatccc aagctgataa 1515481 aagaagtgcg caaagaacaa agaagctggc aggacgtata tgaaaattgg gtcctcttcg 1515541 gggagagcga cccgatttgg gatccatatc gggaaccgga agaagcttct gaagctgtgc 1515601 ctgaaacacc gcaaaaaaat gattttgtct cgaaaatggt gacagcggtg aaaaagatgg 1515661 atgtcaatca aatgaacgaa caaatcaata aaatgagcca gtcgatctca tcgttgcaaa 1515721 gccttcttaa tacattttcc ggaagcggac agaagcattc tcagccaggc tctggacagc 1515781 atcctttttc ttttcgaaag gattaaaaaa ggggagctca tatgcgcaaa gaggttcagg 1515841 aatatatttt agcaaacgaa gaacggaaac gattcatcag agaacagccg atatggtacc 1515901 gcaggctttc aagaaaaccg gatgatctgt cctcctttca gcttgaaatg atgaattttt 1515961 atgaaaaaac cattccgcat cgggtgaatc agtttacgaa cgggattcaa atggcgcaaa 1516021 tgatgatgca aatgtttcaa gcgatgcgga caaaagatta aaaggccccg aagaagggtc 1516081 ttttttcatg cggtcataag gttttgttgg cggctgcggt taagcatttt ccaattggct 1516141 ggtttcatgg taaactaaca actggaggtg catgttatgt atgcgacgat ggaatccgtg 1516201 cggcttcaaa gtgaagctca gcagcttgcc gagatgattc tgcagtcgga gacggctgag 1516261 aactaccgca attgttacaa gcgtctccag gaagatgaag aggcaggtcg gattattcgt 1516321 tcttttatca aaataaaaga gcagtatgag gatgtacagc gttttggcaa atatcatcct 1516381 gactatagag aaatatcccg gaaaatgagg gagatcaaac gtgagctgga cctgaacgat 1516441 aaggtggctg acttcaagag agctgaaaat gagctccagt ccattcttga tgaggtcagc 1516501 gttgagattg ggacagctgt ttcggagcat gtgaaagttc cgactgggaa cccttatttt 1516561 gacggtttgt cttcatgcgg aggcggctgc ggttcaggcg gaagctgcgg atgtaaagtg 1516621 tcctgacgag actggccgtc tcgtctttta catataagag aaaacaggca ggtgattgta 1516681 ttggagaata ggcgccaggg catggttgtg tatctgcact ccctaaagca gagcaaaatg 1516741 ctgaggaagt tcgggaatgt gcactatgta tcaaaacgat taaaatatgt cgtactgtac 1516801 tgtgatatgg accaaattga aaaaacaatg gacaagattg cgtcttactc atttgtgaaa 1516861 aaagtggagc cttcttataa accgttttta aaattggaat tcgagtcaaa gcttgataag 1516921 gcaaaagaat acgattataa aatcggcata tagctataaa aaaatccccg caggcatctg 1516981 cggggtcctt ctattcctta atatgttaag gagaaggcaa agggagagga gaaaccggag 1517041 gaagaactta tggggaaacg taagtcttct ccgcggttgg caacaacatc ctctagatgc 1517101 tgttgcttat agtatggaca aggatcatgc tgcctataca cctgtttatc aagattagcg 1517161 ttcattgttt ggaagaatgc tttatgttaa gataggattg atttttttct atgtacatag 1517221 cggcgtccgg ccgaataaag aaacaaaata gcttttagaa aaagtggtgt ggaacatgag 1517281 agtaatttct ggatcaaaaa aaggccgttc actaaaggct gtagccggaa catcaacaag 1517341 accgacaacc gacaaagtga aggaatccat tttcaatatg atcggccctt attttgacgg 1517401 gggcagggga cttgacttat tcgcagggag cggaggtctt ggaatcgaag cgctttcacg 1517461 cgggtttgag cattgtatat tcgttgaccg tgattttaaa gcgattcaaa cggtaaaatc 1517521 taatttgaaa acgctggagc ttacaaaaca tgcacaggta taccgcaatg atgcggaacg 1517581 tgctttgcac gctgctgcta aaagagaaac cggctttcgc ggaatttttc tcgatccgcc 1517641 gtataaggaa caaaagctga aagcactttt aactttgatt gacgaatatc aaatgctgga 1517701 agaagacggc tttatcgtcg ctgagcatga cagagaggtc gagcttcccg aaaccgtagg 1517761 agatcttgtg atgacaagaa aagaaaccta tgggttaaca ggtgtagcga tttataaaaa 1517821 gagggggtag tgaggtggcg agtatagctg tctgtcccgg cagttttgat cctgtgacct 1517881 acgggcatct ggacatcatc aaacgcgggg cgcatatttt tgaacaagtg tatgtatgtg 1517941 tgctgaataa ttcttcaaaa aagcctttgt tcagtgtgga agaacggtgt gagcttctga 1518001 gagaagtcac aaaagacatt ccgaacataa cagttgaaac atcgcaaggc ctgttaattg 1518061 attatgcaaa aagaaaaaat gcgaaagcga ttttaagagg cttgagagct gtatctgatt 1518121 ttgaatacga gatgcagggg acatcagtaa accgggtgct tgatgaatct attgagacgt 1518181 tttttatgat gacaaacaat caatattcgt ttctaagttc aagcatcgta aaagaagtgg 1518241 caagatacaa cggctcggta tcagagtttg taccgccgga agtagagttg gcgcttcagc 1518301 aaaaattcag acaaggatga gggttttgac tcatcctttt tttgttccgt ttgtcagtct 1518361 gtaagaaaaa atgataatgt acgtaaacag cgcgcatagt gtgacagcag gtccgatctg 1518421 cacaagcaga ttccagccgt ttataaaggc agttgacatg tcactgctgt taagagattt 1518481 aaatacatac tgatacggat catgccatgc tgtgtaaaga ggtttccata aaagcatgac 1518541 gaagacagcg gcataaacgc cctgcagcaa acgtgcgata aagaatggtt taaatctaat 1518601 gtcggtttcc gataaaatac ctgccacctg agcttgtacg gaaaagccgc taaacccaag 1518661 aataaagctg acgataatgg ctttttgcag aagagaaaca tctgtctcgc tgacaagctt 1518721 gctgcctaat gtaatttcaa acatccctga taaaagcgga atgtccaatt gagtcggaag 1518781 ctgaaacaaa gtcagtgctc cttttgtgaa aacagacaaa acatcagtca gctggaccac 1518841 tgacaacagc cgattgaaga cagaaaataa aataataaag ccgcctacca taagaagcgt 1518901 ttgaacagaa gacgtcacgg cgtcgcctaa aattttacct aagggccgtt tttctgcaag 1518961 tctggcggta tgaagagcgt gtaaagcatc tttgactgaa gggaaaggta tcgttttctt 1519021 tcttctgaga tgctgctctt ccttgcggcc ataggagcgc attgttaaac cgacggcaag 1519081 attccccaaa tagtgtgcag aagctaataa aatgcctagt gatgcgtttt gaaagaaacc 1519141 gacggcaaca gcgccgaaaa taaagagcgg gtttgaagaa ttggtaaacg acgcgagccg 1519201 ttctgcctct actcttgaaa tctgattttc ctgccgcaga cgggcagtga gttttgcgcc 1519261 cgctgggttt cctgatgcca ttcccatagc aagaacgaag ccgccgacac ccggcacgcg 1519321 aaagatcggc cgcataaaag gctcaagcaa aacaccgaca aaccgcacaa tgccaaagcc 1519381 gattaagagt tcggacagaa taaaaaatgg cagcaatgac ggaaacacaa cctcccacca 1519441 catagacagc ccggttttag aggcttcgaa tgaggcctgt ggatgtgaga tgacagtcgc 1519501 tgttaaaaaa agaaaaaacg aggcaatcaa aagtgtatta atcttcgaca agttcattct 1519561 tacctccccg atgctaaaaa tgcccaatga catgtatatc atgataaaat aatgtatgat 1519621 gtaaaacggc caagcagtac ctgtcctctt gattctttgt actaatatac gagcataggg 1519681 gttcagttta gaccatagaa ttcggtatac agggaattca ggcaggaggt taacgctttg 1519741 gccaaaccta aaatcgggtt agcgttagga tcgggagggg ccagagggct tgctcatctc 1519801 ggtgtgcttt ccagtttaca taagcaccaa attgaagtgg atatgattgc aggaagcagc 1519861 atgggcgctt tggtgggcag tttttacgcc gccggacatg acgtggcaac gatgaaaaaa 1519921 gtagccaaag cctttaaacg aaggctttat gctgattata cggtgccgaa actcggtttt 1519981 ttaaaaggtg accgcgtcag acagcttgtg catgcttata cattcggaaa accgattgaa 1520041 gagctccaaa tcccgctggg cattgttgcg tgtgatctac agacgggaga aaagattgtg 1520101 ttccgaaaag gatcagtgtc agatgcagtg agggccagca tcagcatccc gggtatcttt 1520161 attccgcagc ggctggacgg acgccttctt gtagacggcg cggtcgtcga tcgaattccg 1520221 gtttctgttg tgaaagacat gggagctgat attatcatcg cttcggatgt ttccagggtt 1520281 cgaaaaactg aaacagcagt gcatattttt gatgtgatta tgcaaagtat ggatatactg 1520341 caaaatgaat tagtgcggca tcaaacaatt gccgcagata tcatgattcg cccttccctt 1520401 gaaacataca gctcaagctc gtttgccaat attgaagaaa tgatatcggc aggcgaagag 1520461 gcgacaaacc gaatgatcag caagataaga aaagaaatag agaattggga gggctcataa 1520521 tttgctacgt aaaaaacatt ttagctggat gctcgtcatc ctcatactga tcgccgtttt 1520581 atcatttata aaacttccat actatattac aaaaccggga gaagcgacag agcttgcttc 1520641 attgataaaa gtggagggag gctacccgga aaaaggaagt ctgtccttaa tgactgttaa 1520701 agtgggaccg gctaatccat ttacatatgt gtgggcaaag atgcaccctt attatgaaat 1520761 tgttcctgat gagagcatta aggaggaagg cgaatcagat aaggagtata tgaaaagaca 1520821 gctccaaatg atgaaaagct cgcaagaaaa tgcggttata gccgcctatc aaaaggcagg 1520881 aaaaaaagtc agctattcct ttaacggcat atacgcaagc tcagttgtag aaaacatgcc 1520941 ggcaaaaggg aaaatagaag tcggtgataa aatcatcagc gcagacggca aaaactatca 1521001 gtctgctgaa aagctgattg attatatcag cagcaaaaaa gcgggagata aagtcacgtt 1521061 aaagatcgaa agagaagaaa aagaaaagcg tgtcaccctt acgttaaaac aatttcctga 1521121 tgagccggat cgggcaggaa tcggagtttc gctttataca gacagaaacg tgaaggtaga 1521181 gcctgatatt gattttgaaa tcgaaaatat tggcggcccg tcagcagggt taatgatgtc 1521241 ccttgaaatc tataatcagc tgacaaaacc agacgaaaca aaaggctacg atattgcggg 1521301 aacaggtacg attgatgttg acggaaaagt aggcccgatc ggcggcattg atcaaaaagt 1521361 cgtcgccgca gacaaagccg gaaaagacat tttcttcgcg ccaaatcaaa acggcgccag 1521421 caattccgat tataagaacg cagtaaaaac agcaaaagat attgattcaa atatgaagat 1521481 tgtgcctgtt gataccatgc aggatgcgat tgattatttg aataagctga aagcgaaaag 1521541 cacctgattc tcaggtgctt tttctataca tttaaaaagt gttgttcatc ttcgtcatat 1521601 cgaatcggtg catgtccgta ttcctgtagg tcaaactcag ttctcagcgg ctcttctatc 1521661 ggcaggctgt aaatcctgct tgcttttacg tccagatcga gagctggatg ggagaaagag 1521721 gacagtttgc tgacaagcgg aacagacagt gcttttttct tttcggataa ataagcctgt 1521781 ccttttttcg tcatgccgag aagcctgata tacggcgcct tatcgttgtc aagcagcttt 1521841 tgcatatcct gtttttttgt tctggttaaa atgtgtgtat tcatccgctg gagccttgtc 1521901 cacgtatagc gttttgtttt cagcagttcc ataaattcct gataggagct ggattttctg 1521961 atcgaacgaa taattctgtg ctctaaacct tcctccacct cgtatacttg ctgtaattcc 1522021 cgtgccgtta cagttgaaag gctgtatttt aagtaagaaa agtagctttc aggtgtatgc 1522081 cacaatccga aagatttgcg gtaagctgct aattcacgtg cagatgcagc agggagaaaa 1522141 cgaaggcagg cttcgagatt ctggccaatc atcgcttttc taatgcttgt ggcacttgct 1522201 atatggtttt cgccttcagg gagatcggca tcatgatagt ccgaagagat tcgtgccgta 1522261 gtataaggtt tcataggata tcccccggtt agaatcgagg tcacatactg gtatcccaaa 1522321 atgttatttg gttttgacaa gtcaagtgca ctttcagtat gcaaaatgga gctgaaggcg 1522381 atagccgccg ctgctgggta actggccccc tttttaagtt cttctttaat tcggtcattc 1522441 aatatatgtt tatgctcatc aataagctgt gctgtttcta aaaaaggctt gatatcccca 1522501 ttttcactcc cgaaaaacag cgcctcacat tcaagttcgt tcaggatgga aacactgccg 1522561 cgtgcaaaaa tgtctgcttt ttgcacggca taaagataag gcagctcaat gacaagatca 1522621 actccgcttt gcagcgccat ttttgttcgg gcccattttg atacaacagc gggttccccg 1522681 cgctgtaaaa aatgtccgct catgaccgcg acagccgtgt cacatccggt ttgcagcttt 1522741 gctgtttggg catgataaag gtgaccgtta tgaaagggat tatattcaac caccaatccg 1522801 acagctttca tattttttcc gcctttcttg ctatgtttaa aaacgtatgg tacatttgca 1522861 aatgaaaact cttacgcctt atttttgttt taagtgtatg catagcatat tccgctgtca 1522921 acgatacttc aatggcagca ttatgctgta aagaaaaaat attgacaaaa acaatcttaa 1522981 aagctataat catgtttgtt gctttcctga ggtgatacaa atgaaatgga cgatttatca 1523041 gctgcatcaa atgccaaaac aaagttttga gtttgatgaa acagttgagt taaatgagct 1523101 gacaaagctg aattctgaca ttcgccgcat ttctcccgtt cgggtgaagg gcagagcgga 1523161 tatcaaatcc aaacaggttt cgtttgattt tacaatttca ggcgaaatgc ttttgccatg 1523221 ctcaagaaca ctcgttgatg ttccgtatcc atttgaaatt tcaacaaaag aactgtttat 1523281 atttcatcac acggatgata tagaagatga tgacgttcac attgttgagg acgatactat 1523341 cgacataact ccgatcgtga aagaagaaat tcttttagaa atccctatgc aaatcttttg 1523401 tgaatctgaa caagaaaaag gagctgctcc tcaagaagga aaggattggc aagtcatttc 1523461 ggaagaagac aagaagaatc aagttgatcc gagacttgca gcccttgaaa agctcttaaa 1523521 acaagatgat gaatcttaac tctttaagga ggtgggaata atggctgtac cttttagaag 1523581 aacttctaaa atgaagaaaa gattgcgccg tacacatttc aaacttaatg tacctggtat 1523641 gacagaatgt ccgtcatgcg gagagatgaa gttgtctcac cgtgtatgca aagcatgcgg 1523701 atcatacaac ggcaaagaca taaatgtaaa aagtaactaa tgagaaaagc gcagggtgaa 1523761 agccctgcgc tttttctttt tctcttcctg tcagcttgcg gaaaatttgt gagtgcaaat 1523821 agtctatcta atctattacc ggcatatgta tgagataaat aagctgacat ggagggagat 1523881 tgaatttgac cattacaaga caagatgctt ggactcagga tgaggatttg ctgctggcag 1523941 aagtggtgct tcgtcatatt cgagagggag gaacacagct ttcagccttt gaggaggttg 1524001 gaagggcgct gaccagaacc gcggcagcct gtggtttcag gtggaactcg tatgtgagaa 1524061 aacaatacca gtcaggtata gagcttgcaa aaaagcaaag gaaagaactg agaaagcaaa 1524121 tcggcgttca ttcggtcaat atgccgaatt ccatgaagca gactgcctcg gcatcgtcag 1524181 aaggaaaacg agatttgtcc attcaggatg tcattcaatt tctcgaacaa ttcaaagaaa 1524241 caccgtctgc acaagaattt cagcttgaaa gggaaaaatt gaaggagcaa atccaatcgc 1524301 tgcaaaaaga gcttgaggat ttgcggagtg aaaatcagac attgcggaat cagctagaga 1524361 tgacagaaga ggattacaag gcactgatcg atatcatgga tcgggccaga aaaatggttg 1524421 tttcgaagga agacggaaga atgaaaaaag cggctcaaga aacgtaaaga aacgcctgaa 1524481 atgaaccggc cctatagtaa gaataggccg gttgttttga tttctatgca gactctcccg 1524541 gtgtcatttc gcgatccata tcaggatgcc agatgagcgg gttttcccct ttgtcccgcg 1524601 ccatatcata cttaacagtt ttaaagttca ttttgttcca aaattccgct gatttcattc 1524661 tcggatttgt ccggatcggc attttgaatg attttgcaaa ttcaaccaag gctctcccgt 1524721 atcccctgtt ctggtagccc ggaagaacct caagcttcca cagctccaaa taatcctggc 1524781 ggttgtcaaa atagggattc gatttgccgt taacttgata cagactcatt cgtgctacaa 1524841 gtttatcgcc aaaataaatc ccgtaaaaag gcgaggtgct gtcattttca ataatattat 1524901 cctgaagttc ttcaagcatt gaaagctcct gaatgccgta ttctttgaat ttcttgaatt 1524961 cttccagcgt tttatagttg ataagcagac gttctacctt tgtcaaacaa atctccccct 1525021 ttgttgtttc tacatatatt gtaaacgctt tatttaaaaa atccaaatat ttaaacttta 1525081 attttaagca catgggatct ttgagaagta atttcttctt acttctgcta tgataatacg 1525141 taaatgctaa attgggtgtg acatcatgaa aattggaatt atcggcggag gctccgttgg 1525201 tcttttatgc gcctattatt tgtcacttta tcacgacgtg actgttgtga cgaggcggca 1525261 agaacaggct gcggccattc agtctgaagg aatccggctt tataaaggcg gggaggaatt 1525321 cagggctgat tgcagtgcgg acacgagtat caattcggac tttgacctgc ttgtcgtgac 1525381 agtgaagcag catcagcttc aatctgtttt ttcgtcgctt gaacgaatcg ggaagacgaa 1525441 tatattattt ttgcaaaacg gcatggggca tatccacgac ctaaaagact ggcacgttgg 1525501 ccattccatt tatgttggaa tcgttgagca cggagctgta agaaaatcgg atacagctgt 1525561 tgatcataca ggcctaggtg cgataaaatg gagcgcgttc gacgatgctg aaccagaccg 1525621 gctgaacatc ttgtttcagc ataaccattc ggattttccg atttattatg agacggattg 1525681 gtaccgtctg ctgacgggca agctgattgt aaatgcgtgt attaatcctt taactgcgtt 1525741 attgcaagtg aaaaatggag aactgctgac aacgccagct tatctggctt ttatgaagct 1525801 ggtatttcag gaggcatgcc gcattttaaa acttgaaaat gaagaaaagg cttgggagcg 1525861 ggttcaggcc gtttgtgggc aaacgaaaga gaatcgttca tcaatgctgg ttgacgtcat 1525921 tggaggccgg cagacggaag ctgacgccat tatcggatac ttattgaagg aagcaagtct 1525981 tcaaggtctt gatgccgtcc acctagagtt tttatatggc agcatcaaag cattggagcg 1526041 aaatacaaac aaagtctttt gagctttttc ggtaacatgc tatactcatt tcggatcact 1526101 aactatttat tggagaaagg aagttctaga agatgcagct aactgaactt tccatcaaaa 1526161 atcagaatgt gtttgtacag cactatatag atggcaaaga agaaatgtct tctttttttg 1526221 attacagtat tcatcataag gacatgtggc gcgaaagact ggaagactta tcttcccggt 1526281 ttttcgcaag agaggaattg gcggcgtact taacctctta ccataataaa ttcggttcaa 1526341 gtgcgatgca gtctgctatt gagaagctga aggacccgtc aagtgccgct gtagtcggcg 1526401 gacagcaggc aggactttta acaggaccgc tttacaccat acataaaatc atttcaatca 1526461 ttgttttagc aaagcaacaa gaaaaggaac tgcaagtgcc tgtcatacca atcttctggg 1526521 tggctggaga agaccacgat ttggatgaga ttaattttgt tcacacatct gaagagaatg 1526581 ggcctgtgaa aaaaaagctg cctcagtctt attggaagaa atcatcagca gcgagtacat 1526641 cgcttgatca ggaaaagtgt gccgcgtgga tagatgatgt ttttgccgct tttgaagaaa 1526701 cagaccatac gaatacactt ctcgacaatg tgaaacgatg tttaagggaa tctgttacgt 1526761 ttactgactt ctttgaactg ctgatcgcgg atttgttcca agaagagggc ttagttttat 1526821 taaattctgg ggatccgggg attaaaaagc tggaaacggc catgttccaa aagattcttc 1526881 gagaaaatga tgaactcgcc cgggctgtat cagatcagca ggccttcatg cgtcaagcag 1526941 gctacaaacc gattatcgag tccggaaaag agcaggcgaa tctgttttat gaatacgaag 1527001 atgagcgttt tttaattgaa aaagataacg gccgatttgt catcaaagag cttgatctag 1527061 gatggacgag ggatgaactt catacacata tggaagaaca tccagagcgt ttcagcaaca 1527121 atgttgtaac gagaccgtta atgcaggaat ttctcattcc gactttagca tttattgcag 1527181 ggcctgggga aatcaattat tggggcgagc tcaaacaggc atttgcggtg atgggcttca 1527241 aaatgcctcc tgtcatgcca aggctgaaca ttacgatact tgagcggcat attgagaaaa 1527301 aactggctga acggaatatc tcattacaag acgcgattga gcgcggaacg gagaatcaaa 1527361 gagagacata cttcgagcgc cagattccgg aagagtttac ggcggtgatg gatcaggcga 1527421 aaagccaaat tgaagcgatt cacaaaacgg tccggcagga ggcgttaaag gttgatcaaa 1527481 gcttggaacc tttacttctg aaaaatgccg cttttattca ggatcagctt caattcttag 1527541 agcgcacggt gatgaagcga attgaagaaa aagaaggcta cgtcttgaag gattatgaaa 1527601 gaattcaaaa tagcattaag ccgcttcttg cgccgcaaga acggatttgg aatatcatgt 1527661 attatttgaa caggtacggt ccaaaattct tcacgacatt caagaatctg ccattttctt 1527721 ttcaaaatca acatcaagtt gtcaaacttt gaaataaagt tttaaagaac cctgactagt 1527781 tcagggtttt tttttatggg taaacagtgt aaaatgaagt tgtggagcga agtggtgaat 1527841 agtggtgagt taaggagaga aagtggggca agagatcatg tttatgggtg aatatcagca 1527901 taccatcgat gcgaaaggcc gcatgatcgt acccgctaaa ttcagagaag gcctaggtga 1527961 gcaatttgtg ctgactagag gacttgacca atgtctcttc ggctacccta tgcacgaatg 1528021 gaaacaaatt gaagaaaaac taaaagctct tcctctcaca aagaaagatg cccgcgcgtt 1528081 tacccgtttc ttcttttcag gggcgactga atgcgaactg gataagcaag gcagggtaaa 1528141 tatcgcatca tctctattga attacgccaa actggaaaaa gaatgtgttg ttatcggggt 1528201 ttctaatcga attgaattgt ggagtaaagt aatttgggaa caatacacag aagagcaaga 1528261 agattcattt gctgaaattg ctgaaaacat gattgggttt gatatataat gattcttcgt 1528321 gtataacact ctaaaaacaa tttcaattca tcctgataaa aggtgggacc aacacaatat 1528381 gtttcaacac aagacagtac ttcttcgtga aaccgtagac ggacttaata ttaaaccaga 1528441 cggtacatat gtagactgca cactcggcgg agctgggcat agtacatact tattgcagca 1528501 gttatccgag aaggggcgtt taatcgcttt tgaccaagat gatacggcat tacagcatgc 1528561 taaagaagtg ttgtccgatt ataaaggaca gctcattctg attaaaagca atttcaggta 1528621 tttaaaagaa tatttgaatg aacaaggcgt tacagaagta gacggcattt tatttgattt 1528681 aggggtgtcc tctccgcagc tggatacacc ggagcgcgga ttcagttacc atcatgacgc 1528741 accgttggac atgaggatgg accagtcggc tacgctttcg gcgaaagaag tcgttaatga 1528801 gtggcgctat gaggatctcg tccgtatttt ctttaaatac ggagaagaga agttcagtaa 1528861 acagatcgcc agaaaaattg aggaggcaag aatgaagtct cctattcaaa ctacgggcca 1528921 actggtcgat ctaataaaag acgcgattcc cgctccagcg agaaggagcg ggggacatcc 1528981 cgctaaacgc gtgtttcagg caatcagaat tgccgtaaac gatgaactta gggtgtttga 1529041 agaagctttg gagcaggcaa ttgaggttct gaagccaggg ggcagggtat cggtcattac 1529101 cttccactcg ctagaagaca gaatttgcaa aaccactttt aaagaaaagt cgtcgcttcc 1529161 ggaacttcct ccgggacttc ctgttatacc ggaagagttt gaaccggagc tgaagctcat 1529221 cacacgaaaa ccgattacgg catctcaaga agagcttgaa gagaacaacc gggctcgttc 1529281 tgccaagctt cggattgctg aaaaaagaaa ataacgaaac gcgaacgcaa aattaaaagg 1529341 aggtcatcag cctatgagca atttagctta ccaaccagag aaacagcagc ggcatgcgat 1529401 cagtcctgag aaaaaagtga ttgtcaagaa aagggcttcc attactctcg gagaaaaagt 1529461 gcttcttgtc ctctttgctg cggcggtgct cagcgtatcg cttttgatcg tatcgaaggc 1529521 gtatgcggca tatcaaacca atattgaggt gcaaaagctt gaggagcaaa tttcatccga 1529581 aaataagcaa attggtgacc tcgaaaaaag cgttgctgat ttaagcaaac cgcagcgcat 1529641 tatggacatt gcgaaaaaga acggcttgaa tttaaaagat aaaaaagtga aaaacataca 1529701 ggaatgattc aaatgccaaa aaagaataaa tttatgaata gaggagcagc gattctaagt 1529761 atttgtttcg ctctcttttt ctttgtcatc ctggggagaa tggcatatat tcaaataacc 1529821 ggaaaagcga acggcgaagt gcttgcgaca aaagcgacag agcagcatga aaagaaacgg 1529881 accatcgaag cgagccgcgg ctcgatttta gaccgaaaag gaaaagtcat tgcagaggac 1529941 acagcgacgt ataaactgat tgcgattctc gataaaaaaa tgaccactga tgtcaagcat 1530001 cctcagcatg ttgtaaacaa agaaaaaacg gcggaagcat tgtctaaagt gataaacttg 1530061 gacaaggccg acatccttga tatcttaaat aaagatgcaa aacaagtcga gtttggctca 1530121 gctggccggg atattacgta ttcacaaaag caaaaaatcg aaaaaatgaa actcccgggc 1530181 atttcatttt tacgggatac aaaacgctac tatccaaacg gagtatttgc atctaatcta 1530241 atcggctatg ccgaggttga tgaagaaaca aatgaaattt ccggcgcgat gggattagaa 1530301 aaagtgctgg ataagtattt gaaggagcgg gacggatatg tgacatatga aagcgacaaa 1530361 tccggctggg agctcccgaa cagcaaaaat aaaattacag cgccaaaaaa tggtgacaat 1530421 gtatatttaa ccattgacca gaaaattcaa acctttttgg aagacagcat gacaaaagtg 1530481 gcgcaaaagt ataatccgaa aaaaatcatg gccgcagtcg ttgatccgaa aacgggcaaa 1530541 gtccttgcca tgggacagcg cccaagcttt gatccgaaca agcgcgatgt gacaaactac 1530601 tataatgatt tgatttcata tgcgtatgaa cccgggtcca cgatgaagat ctttacactc 1530661 gctgctgcga tgcaggaaaa cgtgtttaat gcgaacgaaa aatataaatc agggacattt 1530721 gaagttggcg gagcacctgt taaggatcac aataacggtg taggctgggg tccgacaaca 1530781 tatcatgacg gcgtcctaag gtcgtcgaat gtcgcttttg cgaaactggc gaaagaaaag 1530841 ctgggatatg accgcctcaa tcaatatttg cacaaattca atttttacca gaaaacaggt 1530901 attgatttgc caggagaagt ctccagcaaa atcaacttta aatatgaatt tgataaggcg 1530961 tcaactgcat atggccaagc gtctgcggtc acaccaattc agcagattca ggccgcaacg 1531021 gcaattgcaa atgacggtaa aatgatgaaa ccttatgtca ttgaccatat cgttgaccct 1531081 gataaagata aaactattta tcaaaataag ccggaatcag ccggaactcc aatttctgca 1531141 agtactgcga aaaaggtgcg ggatatatta ggagaagtcg ttacatcgaa gatcggaaca 1531201 gggcaagctt ataaaatcga aggttttgat gttgccggga aaacaggtac tgcgcaaata 1531261 gccggtaaag gcggatattt agacggcaca gataactata tcttttcgtt tatgggtatg 1531321 gcgccaaaag atgatcctga gcttttaatt tatgttgctg tacagcagcc gcaactaaaa 1531381 gcaggacaaa gcagttcaga tccagtatca gaaatcttca atccaacaat gaaaaatagc 1531441 ctgcactacc taaacatcga accaactgaa aaatctgact cagataagga agaaacaaaa 1531501 gcgcagacaa tgcctgattt aacagatcaa acggtagctg ctgctcaaaa gaaagcaaaa 1531561 gaggagaatc tcacaccaat tgtcatcggc agtgatgtcg ctgtaaaaga acagtatccg 1531621 aaagcggatg aggaagttct caccaatcaa aaggtcttcc tgaaaacggg cggcaaaatc 1531681 aaaatgcctg atatgacagg ctggtcgaga agagaggttc tgcagtacgg cgagctcgcg 1531741 ggaattcata ttgaagtaag cggacaaggc tacgctgtca gccaaagtgt taagaaagac 1531801 aaagaaatca aagacaaaac cgtaatcaag gttaagttta aaaatcctga ttaaaaagaa 1531861 agccgtcgtt atgcaggctt tcttttttta tgccttcaga ggagcatcgt tctacctgtc 1531921 caaattcagg cataaaatga aacaagccta aataaggagt gaacggtctc ttgcgcgtct 1531981 cgaatgtaac ggttagaaaa cgtttattat ttgttttgct ttttggcgtg atcgtgtttc 1532041 tgatcattga tacaaggctg gggtatgttc agtttgtgat gggcgaaaaa ctgacttcgc 1532101 tagcgaaaga ttcctggagc cggaacttgc cgtttgagcc ggagagaggc gagattctgg 1532161 atcggaatgg tgtgaagctc gcaacaaata aaagtgcgcc gaccgtattc gtcgtgccgc 1532221 gccaagttca gaatccgatg aaaacgagca agcagcttgc ggcggtgctc aatatgtcag 1532281 aagaaaaagt atataaacat gtgacaaaaa aagcgtcaat cgaaaagatc actcctgaag 1532341 ggagaaaaat ttcaaatgag aaggcgaaag aaatcaaagc gcttgattta aaaggtgtgt 1532401 atgttgcgga ggacagtatc cgtcattacc cgttcggcag ctttttatct catgtgcttg 1532461 gatttgcagg aattgacaac caagggctcc ttggacttga agcctattac gacgatgatt 1532521 taaaagggga aaaaggttct gttaagtttt atacagatgc caaggggaag aagatgcctg 1532581 atgaagcgga tgactatacg ccgcctaagg atgggcttga tatgaagctg acagttgatt 1532641 caaaggttca gacgataatg gaaagagagc ttgataacgc tgaggccaaa tatcatccgg 1532701 acggcatgat tgccgtagcc atgaatccga aaaacggaga aattttgggg atgtctagca 1532761 ggcctgactt cgaccctgct gattaccaat ctgttgatcc gtccgtctac aatcgaaatc 1532821 tgccagtatg gagcacgtat gaaccgggat ctacctttaa aattattaca cttgcagcag 1532881 cccttgaaga gcaaaaagta aatttgaaac gggatcaatt ttatgataaa gggcatgctg 1532941 aagtggacgg agcgagactg cggtgctgga aaagaggcgg gcacgggctg cagacgtatc 1533001 tggaagttgt gcagaactcc tgcaacccgg ggtttgttga attaggcgag cgcttaggaa 1533061 aggaaaagct tttcaaatat atcaaagact ttggttttgg acaaaaaacg gggattgatc 1533121 tccaaggcga gggaacaggc atcttattcc cgcttgagag agtgggcccg gtggagcaag 1533181 caactacggc tttcggacag ggagtatccg tcacgccgat tcagcaggtt gcagcagtat 1533241 ccgccgctgt aaacggagga acgctctata caccttatat tgcaaaggaa tggatcgatc 1533301 ctgttacgaa gaaaacggtc aaaaaacaat caccaatcgc aaagaaacaa gtcatttctg 1533361 aggaaacatc caaacaaatc cgctatgctc tagaaagcgt cgtcgcagaa ggaaccggcc 1533421 gcaatgcatt tgtagaagga tatcgtgtcg gaggaaaaac gggaactgca caaaaggtta 1533481 aagatggaaa atatcttgaa aacaaccata ttgtatcatt tatcggtttc gcgccagcag 1533541 atgatccgag tctagtcgtc tacgttgcgg tggataaccc gaaaggcacg attcagtttg 1533601 gcggaacggt ggcagcgcct attgtcggaa atattatgag agacagtctg ccggaacttg 1533661 gtgtgaagcc ccggaaaaat caaatcgaga aaaaatacca atggaacgac acaaaaacaa 1533721 tagaagttcc gaatgttgta gggatgtctg tctcagatct tgagtcacta ttggtgaatc 1533781 tcaatgtgga tgcttccggg aaagggagca aaatcgttaa acaatcgcca gctgccggaa 1533841 cgaaagtaaa agaaggctca aagatacgcg tgtatttgac tgaagaagat gaaaaggagg 1533901 cagccgattg attcgggctg cctattcttt tattgcagaa aaaatgctga tatctttcaa 1533961 gattagctgg atgtatcctt ttatttacgc taaaatatga actgtatgct taaaatcatt 1534021 accacatcat ttgatgtgac ttcaatgata aaaagaacga attagaatgt tgagaggttt 1534081 gatacgatga aacttacaaa gctgcttaca tacttaacaa ccgaaccttc tgtaaacgac 1534141 tcacaagacc ctgaaataac ttcaattgag atggactcca gggaagtaaa gaaagggagt 1534201 ctttttgtat gtgtaaaagg gtatacggtg gatggccacg attttgcgca aaaagcagta 1534261 gaaaacggtg cagcggctat tgtggcagaa agagaggtcg atgtgaatgt tcctgttatt 1534321 attgtccggc agtcacttcg cgcgctcagc gttttgtctg atgcgtttta cggacagccg 1534381 acgaagaagc ttcagctgat tgggataaca gggacaaacg gcaaaacatc aacgacccac 1534441 atggtcgatg agattctgaa aaaagcggga aaacgcacag gcttgatcgg tacaatgtac 1534501 atgaaaatcg gagacgaaac acttcctgtt aaaaacacga ctccggaaag cgtcacgctg 1534561 cagaaaacgt ttaagaaaat gaatgacaag cacgttgaca ctgcaatcat ggaggtttct 1534621 tcccacgctt tgtctttagg acgcgtccat ggctgtgatt atgatattgc cgtgtttacg 1534681 aatttaacac aggaccatct ggactatcat aaaacgatgg atgagtaccg gcatgcaaaa 1534741 agcttgctct tttcccaact tggcggggct ttcaaccatg aacatccaaa gcgtgccgtc 1534801 ctgaatgctg acgatgaggc gagcgcttat tttgaaaagg taacagctgc gcatatctct 1534861 acatacggaa ttaaaaacga tgctgatgtg atggcgaaga acatcagtat cactgcacag 1534921 ggcacaagct ttgatctcgt gacaaacaaa ggcacgaagc acatcacgat gtctctcgtc 1534981 ggacaattta atgtgtataa cgtgctggcc gctgttgcga catgtattgc agcaggcata 1535041 ccgtttgaaa tcatcactga ggctgttgaa gaattgcatg gtgtaagagg ccgttttgaa 1535101 ttggtcaatc agcagcagga gtttcctgtc attgtagact acgcgcacac accggacagc 1535161 cttgaaaatg tgctggagac atgcagagac atgacggaag gaaagctatt tgtcgttgtc 1535221 ggctgcggag gagacagaga taagacgaag cgcccgaaaa tggctaaaat tgctgtggag 1535281 ctggctgacg agccgatttt cacgtcagat aacccgagaa gcgaagatcc tcgcgcgatt 1535341 ttaagagata tggaagccgg agtagagaac gcatactatc acagtattgc aaaccgcgag 1535401 caggcgatct ttttcgcaat tgccaatgcc aaaaaaggcg acgttgtcct cattgccgga 1535461 aaaggacatg aaacctatca gcagatcgga aatgaaactt tcgattttga tgatgctgaa 1535521 gtagcggcga gagccattgt tgaactcaat aagaataaga cgaattcata ggaaagagat 1535581 gttactgaat aatggagctt gaaaagattt ttcatatgga aaaaaatcat gaatatgata 1535641 actacgtatg tcgtttgaaa gaaacaggag gagaaaagga caatgcttga gcaagtcatt 1535701 ctgtttacaa ttttaatggg gtttttaatt agtgttctgc tctctccgat tcttattccg 1535761 tttttaagaa gattaaaatt cggccagagt attagagaag aaggaccgaa atcacatcag 1535821 aaaaaatcag ggacaccgac aatgggcggg gtcatgatca tactttctat catagtgaca 1535881 acaattgtta tgacacagaa gttttcagaa ataagccccg aaatggtgct gcttctgttt 1535941 gttacgctag gctacggttt gcttggcttt ttagatgatt acatcaaggt tgtcatgaag 1536001 cgcaatcttg gattgacatc aaagcaaaag ctgatcggac aaattattat tgcggttgta 1536061 ttttacgccg tgtatcatta ctacaatttt gcgacggata ttcgcattcc tggaactgac 1536121 ttatcatttg atcttggctg ggcttacttt atccttgtgc tctttatgct agtcggcgga 1536181 tcaaacgcag ttaacctgac tgacggcctt gacgggttat tatccggtac tgcggcgatt 1536241 gcctttggcg cctttgccat tctggcatgg aatcagtctc aatatgacgt agcgattttc 1536301 tcagttgccg ttgtcggtgc agttctgggc ttccttgtat ttaatgctca tccggccaaa 1536361 gtttttatgg gagatacggg atcgcttgca ttgggaggag ccatcgttac cattgccatt 1536421 ttaacgaaat tagagatcct gctggttatc atcggcggtg tattcgttat cgagacatta 1536481 tccgttattt tgcaggtcat cagctttaaa acgacaggta aacgaatctt taaaatgagt 1536541 ccgcttcatc accattatga gcttgtcggc tggtctgaat ggagagtagt cgtgacgttt 1536601 tgggctgcgg gacttttgct tgccgtttta ggaatttaca tcgaggtgtg gttataagtg 1536661 gaaaatgatc aatttttaca gaaacagcat tttttaatcc ttgggcttgc gaaaagcgga 1536721 tatgcggcgg cctccattct tcatgaaaaa ggcatttatg ttgcagtcaa tgatcaaaag 1536781 ccttttgaag aaaatgaacc ggcacaaaag ctttctgaaa aaggaatcga agttgtttgc 1536841 ggagagcatc cagtttctct gttcgatcag catcaaatca cgattctgat caaaaacccg 1536901 ggaattcctt atgaaaatat catggttcag gaagcagaga aacgaggtat tccggtttgg 1536961 acggaaattg agctcgctta ctacctgacc agcgccaagt ttatcgggat taccggatcg 1537021 aacggtaaaa cgaccacgac aacgctaatt tacgaaatgc tcaaggctga ctcgcaaaaa 1537081 gcactgattg ccggaaacat cggcacagtc gcaagtgagg ttgcctatca tgctgatgga 1537141 gatgaatgga tcgttaccga actgtcttcg tttcagctga tgggaacaca cgctttcaga 1537201 ccggaaatca gcctgatttt aaatgtattt gacgcccatc tggattatca ccatacgcgc 1537261 gaaaactatg aaaaagcgaa acagaaagtg taccttcatc agactgcttc agataaagct 1537321 attgtcaacc aggatgatga aaccgtcgtg cgtcttgctg aagccggaaa agccgaaatc 1537381 gtcccatttt cagtcagcaa aacgcttgaa cagggcgcat atgtaaaaga cagtatgatt 1537441 atgtttaacg gcgaagccat tcttcctctg gaagaggttg tactgcccgg tgctcataac 1537501 ctggagaaca ttttagcagc tattgcagtt gtgaaaacgg caggagcatc caatgaggcg 1537561 gttaaaaagg tgctgacaag ctttactggt gtgaagcacc gcctccaata tgtcacaact 1537621 gtgaatggcc gcaaatttta taacgacagt aaagcaacaa acattctggc gacaagcaag 1537681 gcgctttcag cttttgataa gccggtcatt ctgcttgcgg gcggactgga tcgcggaaat 1537741 ggttttgatg acttgaaacc ttatatgaag catgtcaaag cagtgcttac atttggccag 1537801 acggcgccaa aactcgagaa actcggcaat gaactgggaa tacaacatgt caaacgtgtc 1537861 gataatgttg aacaagcagt atctgcggcg tttgcgctct caaatgaagg agatgtcatc 1537921 ctgctgtcac ccgcgtgtgc gagctgggat caattcaaaa catttgaaga acgcggtgac 1537981 atgtttatag atgccgtgca tatgcttaag taagggcttg tcttgaagta aatcggcagc 1538041 cctaatgact ttaagcttgg ggtgtcgatt gctttgacta ctaaaaaaac atcgcctgat 1538101 ttgttattgg tcatcattac gttattatta ttaacaatcg gattaattat ggtgtacagt 1538161 gcgagtgcgg tatgggcgga ttataaattt gacgactcat tctttttcgc gaaacggcag 1538221 cttttgtttg cgggaatcgg cgtcattgct atgtttttta tcatgaatgt tgattattgg 1538281 acttggagga catggtccaa attgctgatg gttatctgct ttttccttct ggtgcttgtt 1538341 ttgataccgg gcgtcggaat ggtgcggaac ggttcaagaa gctggatcgg agtcggagca 1538401 ttcagcatac agccttcaga gtttatgaag cttgcgatga ttgcattcct tgctaaattt 1538461 ctctctgaaa aacaaaaaaa catcacatcg ttcagacggg ggttcgtccc tgcacttggc 1538521 atcgtgtttt cagcattttt gattatcatg tgccagcctg acctcggaac ggggacagtt 1538581 atggtcggaa cttgtattgt catgattttt gtagccggcg cacggatcgc ccatttcgtc 1538641 tttctcgggc tgatcggcct cagcggattt gtcgggctcg tactatcggc tccatatcgg 1538701 ataaagcgga ttacctcata cttaaatcca tgggaagacc cgctcggaag cggatttcag 1538761 atcattcaat cgctttatgc agtggggccc ggcgggttgt tcggaatggg gctcggacaa 1538821 agcagacaga agttctttta tctgcctgag ccgcaaacag actttatttt cgccatcttg 1538881 tcagaggagc tgggctttat cgggggaaca cttattttgc tcctcttcag cgtcctgctg 1538941 tggagaggaa tcagaattgc gcttggtgcg cctgatctgt acggaagctt tgtcgcagtc 1539001 ggcattattt caatgattgc cattcaagtc atgataaata tcggcgtagt cacgggcctg 1539061 attcctgtaa caggcatcac gctcccgttt ctgagctacg gaggctcttc attgactcta 1539121 atgctgatgg cagttggtgt gctgctgaat gtaagccgct actcgaggta ttaacgaatg 1539181 tatttccaag cctcctgtct aacatgaagc ttggaaacaa ttgatgcgat aaccctgtcc 1539241 aacaaaacag ggttatcgtt atgttataga gaaacttaga ctgggggaaa aaagaaatgc 1539301 gaattgcaat aagcggaggc ggtacagggg gacatattta tcctgctctt gcttttatta 1539361 aagaagtgca aagacgtcat cctaatgtgg aatttttata tatcggaaca gaaaacgggc 1539421 tggagaaaaa aattgttgag cgggagaata taccgtttcg ttcaattgaa attacaggat 1539481 ttaaaagaaa attgtcattt gaaaatgtca agactgtgat gcgttttctg aagggcgtca 1539541 aaaagagtaa atcgtattta gcggaattta agcccgatgc cgtaattgga acgggcggtt 1539601 atgtatgtgg gccggttgtc tatgccgctg cgaaaatggg aattccgact attgtccacg 1539661 aacaaaacag cctgccgggc atcacgaata agtttctttc aaaatatgtt aataaagtag 1539721 cgatttgttt tgaagaagcg aaatcacatt ttcctagcga gaaagttgta tttacgggaa 1539781 acccgagagc ctctgaagtc gtctcaataa agacgggacg atcattggct gaatttgggc 1539841 tttctgaaga caaaaaaacg gtcttaattt tcggcggaag ccgaggcgct gcaccgatta 1539901 accgcgctgt cattgacatg caggatgtgc tgaaaacaag agactatcaa gtgctgtata 1539961 tcaccggtga agttcactat gaaaaagtaa tgaatgagct gaaaagcaag ggtgccgctg 1540021 ataatatggt cacaaagccg tttcttcatc aaatgcctga gtatttaaag gccattgatg 1540081 tcattgtggc cagagccggt gcgacaacga ttgccgaaat tactgctctc ggaatcccaa 1540141 gtgttctgat cccaagtcca tatgtgacag cgaatcacca ggaggtcaat gcgaggtctc 1540201 ttggccagca tgatgcggcg attgtactga aagaaacaga gctcagcggg gagaagctga 1540261 ttgaagcgct agaccggatt gtactgaatg agcaaacgtt aaaggaaatg agcgaacgaa 1540321 caaagtcact cggtgttcct gacgcggctg cccgtttata cagcgtactc gaggaattaa 1540381 aaaaatagta gaaaagcaaa tggaatgcgg aggtttacga tggagaaagt gatacaggaa 1540441 ttaaaagaac gagaagtcgg caaggttctt gcaaatgaac cgctcgcgaa tcatacaacg 1540501 atgaaaatcg gcggacctgc ggatgtattg gtcattccaa gcagtgtgga tgctgttaaa 1540561 gacatcatgg acgtgattaa aaaatatgat gtgaagtgga cagtcatcgg ccgcggatca 1540621 aatcttcttg ttttagatga aggaattaga ggcgtagtga tcaagctggg ggcgggtctt 1540681 gaccatttgg agcttgaagg ggaacaagta acagtcggag gcggttattc ggtggtccgc 1540741 cttgctacat cattgagcaa aaaaggcctg tccggtttgg aatttgctgc cggcattcca 1540801 ggatcagtcg gcggagcggt ttatatgaat gccggcgctc acggttctga tatgagcgag 1540861 atcctcgtca aagcgcatat tttatttgaa gacggaacga ttgagtggct gacaaatgag 1540921 cagatggatt tcagctacag gacatctgta ctgcaaaaga aacgcccggg cgtttgcctt 1540981 gaagctgttt tgcagcttga gcagaaggat aaggaatcaa tcgttcagca aatgcaaagc 1541041 aataaagact atagaaaaaa tacacagccg tattcaagcc cttgtgcggg aagcatattc 1541101 agaaatccgc ttccgaatca tgccgggaac cttgtagaaa aagcaggctt gaaaggatat 1541161 caaatcggcg gtgcaaagat atcggagatg cacggaaact tcatcgtcaa tgcgggggga 1541221 gcatcagcaa aagatgtgct tgatctcatt gaccatgtga aaaagacaat ccgtgaaaaa 1541281 tacgagattg atatgcacac agaggttgaa atcatcggcg gaaatcgctg attcaagttc 1541341 tgactgaagc tgttcatatg atatactgta agcaaacgac aaacggcatc atagtatgcc 1541401 gtttgttttg gaatagacag acttttaaca gctgtttcat ttgaatgagg tgaacaggca 1541461 atgaacccgg gtcaagaccg agaaaaaatc gttaacattg aagagcggat ccctaaaatt 1541521 aaagagcaga ggaaacaaaa ggcaaaccgc cgtctcattt catttattat gctctttttt 1541581 attatggtgc tgatcattgt gtacctgcaa acaccaatca gtaaagtatc aacaatctct 1541641 gttacaggga atgaaaatgt atcaaaaaag gaaattatcg acctttccga tattaacagc 1541701 ggagatactg agttttggag tttggacaag caaaaaacag aaaagaagat tcagcaaaat 1541761 aaattagtga aaaaagcgga gatcagcaaa tcgcttccta ataaaatcaa cattgcaatc 1541821 gaagaatata aagcgattgc ttatttagaa aaagacgatg tgtactatga agtgcttgaa 1541881 aacggctcag ttctgccaaa cgaagtaacg ccggatgatg ccggaccgat tttagtgaat 1541941 tggacaaacg cgaagaagcg gtctcaaatg gccaagcagc tcgatgcgtt gtcaaattcg 1542001 ttaaaacagt cgatttcaga aatttattat acgcctgtaa aaatggatga aaaccgtatt 1542061 aagttgtaca tgaacgacgg ttatgttgtt acggcatcta ttaaaacgtt tgcagaccga 1542121 atgaagacgt atccttctat catctcacag ctaagcagca ataaaaaagg aatcattcat 1542181 ttagaagttg ccacctattt tgaagagttt gggaaaaacg ataaagctgc taaaaaggaa 1542241 gatgaaaatt gaggggcaaa tcagcagtcc ttctttcctt gattatgctt atcgcaggtt 1542301 ttttgatttc attttctttt caaatgacaa aagaaaacaa caaaagcgcg gctgagacgg 1542361 aagagtggaa aaaagaatat gcgctgagag atgaactgct gaaacaagag aaagaaaata 1542421 agaagtttga aaaagaatta tatcaaaagc aaaacaaagt ccgccaggcg gaaaataagc 1542481 tgaagaaaga gaagtcggaa tactataatg tcctcgaaga tacagaaaaa tacaggatgt 1542541 atattgggga agtcggtgtg cagggagaag gcgttgaggt gacattggaa gatgcgtcat 1542601 acataccgga aggggagaat gtgaatagtt acatcgttca cgaaagccat atcttccaag 1542661 tagtaaacga actgtatatc tcaggagcgg cagctgtcgc cgttaatgga cagcgtttga 1542721 cgcatgattc gtatatcaaa tgcaatggtc ctgtggtaac ggtagacggg gtgcagcatc 1542781 ccgctccgtt tacggtatcc gctattggag atccagatgt cctgctgccc tcgttaaata 1542841 tcgctggagg cctaattgat cagctgtcaa tggatcatat ttctgtgtcg gcagaaaaag 1542901 agaaaaacgt acaaatgaaa ccgattctga aaacgaagga atgactgaaa aagcgggtga 1542961 aatagattga aaataaagcg ttccttcata agcatcagtg ttcttatggt catcttcggc 1543021 ctgatgatat ctgttcagtt taattcgtta aagcacccca aagtccggga tacaagagat 1543081 atgtgggata ttagggaaga gctgacatca gagcagaaga agcaggaaaa gctgctggct 1543141 gaaataaaca aatatgacaa attgctgaat agctattcgc aaacgaaaga aatgacaaaa 1543201 gaaaccgcgc taaataatac cttgcaatcc ttaaaaaaaa cagccggcat gaccgatata 1543261 acaggtagcg gaattgtcat tacgatttcc ccgctttttt ctgaaagctt aacaggagag 1543321 ccgatcgaaa atccgcctcc ggatttgctg aaaaagctga taaatgaact caactcctac 1543381 ggtgcagagc atatctcgat taatgagcga agagttgtga atcatacagt catcagagat 1543441 ataaacggca ctacaaaaat agacggatac gcccttgacg attatccttt aacagtaaaa 1543501 gtgcttgcca aagatccgga catgttacac agcagagtga aggggtcagg ccttgaggat 1543561 ctttttgcat ctgaaaattt agcattaaaa gccggtaaat ctgaaagcaa actaacatta 1543621 aaagcatatg acagaccact ggacgtacaa cagctgaaac tgcttaaaga ctgaaaagga 1543681 ggagaattgt catgtggctg cccgtgttgg gactggtgct cggaatagcg attggactaa 1543741 tgacaaactt aacgataccg agtgaatact caaactattt atcgcttgcg gtgcttgccg 1543801 cacttgatac attaatcggc ggaatcaggg cgcatttaca aggtacatat gatgaaatgg 1543861 tatttgtttc cggtttcttt tttaatatta tattggcaat aagtttagct tttctgggag 1543921 tccatcttgg tgtagacttg tatttagcag gtatattcgc atttggagtc agattatttc 1543981 agaatatagc cgttatcaga agaaatctac taacaaagtg gactctttct aaaaaaaata 1544041 aaaaaaatgt gatataaaag aggatataca taggatataa cgaatatttt caataaacat 1544101 aaaatgtgaa aagcacataa aaatattctg ttgttatttt ttgttacaca cttgtaaagc 1544161 cacattcatt gtattgttgt tccgcaaata atagaataga aatgatcgaa atgtgaggag 1544221 gtgccataga atgaacaaca atgaacttta cgtcagtctt gacatcggta cgtccaatac 1544281 aaaagtgatc gtcggagaaa tgacagatga ttcccttaat attatcggtg tgggaaatgt 1544341 accgtctgaa gggttgaaaa aaggctcaat cgttgatata gatgagaccg ttcattctat 1544401 aagaaaagcg tttgaccaag ctgaaagaat ggtaggtttt ccgcttagaa aagctattgt 1544461 cggcgttaat ggaaattata tcaatattca agatacaaac ggtgttgtag cagtttccag 1544521 tgaaaataaa gaaattcagg ttgaagatgt acgccgtgtc atggaggcgg cacaggttgt 1544581 ttccgtaccg catgaacagc tgattgttga cgtcattcct aaacagttta tcgtagatgg 1544641 aagagatgaa atcaccgacc cgaaaaaaat gctgggtgtg cgtttagaag tagagggcac 1544701 cttgatcacc ggttcaaaaa caatcttaca taacttactc cgctgcgttg aaagagctgg 1544761 tattgaaata actgatattt gccttcagcc gctggcagcc ggttctgctg cattatcaaa 1544821 ggacgagaaa aaccttggtg tggctctcat tgatataggg ggagggtcaa caaccattgc 1544881 cgtattccag aacggacatc tcacttctac ccgtgtcatt cctctcggag gcgaaaatat 1544941 caccaaagat atctccatcg gattgagaac gtcaacagaa gaagcagaac gcgtgaaaaa 1545001 gcaacttgga catgcctact atgacgaagc ctcggaagat gaaatatttg aggtaaccgt 1545061 tataggcacc aatcaaaaac aaacatttac acagcaagaa gcagcgaata tcattgaagc 1545121 gagagtagag gaaattcttg aaattgtttc agaagagctt cgcagtatgg gaattaccga 1545181 tctgccggga ggcttcgtgc tgacaggagg acaagcagct atgccgggtg tcatgtcttt 1545241 ggcacaggat gtgctgcaaa acaatgtcag agtggcaagc ccgaattata tcggtgtaag 1545301 agatcctcaa tatatgacgg gagtgggcct gatccaattc gcctgccgga atgcaagaat 1545361 ccaaggcaga aaaataggct ttaagatgcc tgaagaagcg atacaggaaa tcgcagtctc 1545421 atcatctgag gaacaagagc agcatcatca ccaaaatgag gtgcagcagc ggccaaaagg 1545481 aaaacaaaaa acacaagccg aacataataa acagagcaaa atgaaaaaac tattaagcat 1545541 gttttgggaa tagatagata gtcattcggc agattaggag gatttagcat gttggagttc 1545601 gaaacaaaca tagacggctt agcatcaatt aaagtaatcg gagtaggagg cggcggtaac 1545661 aacgccgtta accgaatgat tgaaaatgaa gtgcaaggag tagagtatat cgcggtaaac 1545721 acggacgctc aagctcttaa cctgtcaaaa gcagaagtga aaatgcaaat cggcgcaaag 1545781 ctgactagag gattgggagc aggtgcgaat ccggaagtcg ggaaaaaagc cgctgaagaa 1545841 agcaaagagc agattgaaga agcacttaaa ggtgctgaca tggtattcgt gacagctggt 1545901 atgggcggcg gaacaggaac aggtgccgca ccggttatcg cacaaatcgc gaaagactta 1545961 ggcgcattaa cagtcggcgt tgtgacaaga ccgtttacct tcgaaggacg caaaagacag 1546021 cttcaggctg caggcggaat ctcggcaatg aaagaagcgg tggatacact gatcgtgatc 1546081 ccgaacgacc gtatccttga aattgttgat aaaaacacac cgatgcttga agcattccgc 1546141 gaagcggata acgtacttcg ccaaggggtt caaggtattt ctgacttgat tgctacacct 1546201 ggtcttatca accttgactt tgctgatgtg aaaacaatca tgtcaaacaa aggatctgct 1546261 ttgatgggta tcggtattgc tactggggaa aatcgcgcgg cagaggcagc aaaaaaagca 1546321 atttccagcc cgcttcttga agcggccatt gacggtgcgc aaggcgtcct catgaacatc 1546381 actggaggaa caaacctcag cctatatgag gttcaggaag cagcagacat tgtcgcttcg 1546441 gcgtctgatc aagacgtaaa catgattttc ggttctgtta ttaatgaaaa tctaaaagat 1546501 gagattgtgg tgacagtgat tgcaaccggc tttatcgaac aagagaagga cgtgacgaag 1546561 cctcagcgtc caagcttaaa tcaaagcatc aaaacacaca atcaaagtgt tccgaagcgt 1546621 gagccaaaac gtgaggaacc tcagcagcag aacacagtaa gccgtcatac ttcacagccg 1546681 gctgatgata cgcttgacat cccgacattc ttaagaaacc gtaataaacg cggctaatgt 1546741 aaaggacaaa atcgttttcg attttgtcct tttttgtttt tctcttcaca ctttccttct 1546801 tataaagtct ttttccctat tgcttccttc gcttagtaac aaaacagata attagaccca 1546861 tttatttttg tgacattttt atcattttca tatatatgga aattgaatga catgaaacga 1546921 caatatctgt aattcagatt gtctacagtt aatatacagc gatgttctga caaaccattc 1546981 attattaaaa ggagggacga cacttttttt aaaaagcatg ttgaaaaagg gggatgaaaa 1547041 tgaggaaaaa aacgaaaaac agactcatca gctctgtttt aagtacagtt gtcatcagtt 1547101 cactgctgtt tccgggagca gccggggcaa gcagtaaagt cacctcacct tctgttaaaa 1547161 aggagcttca atctgcggaa tccattcaaa acaagatttc gagttcatta aagaaaagct 1547221 ttaaaaagaa agaaaaaacg acttttctga ttaaatttaa agatctggct aacccagaaa 1547281 aagcggcaaa agcggctgtt aaaaaagcga aatcgaagaa gctgtctgcc gctaagacgg 1547341 aatatcaaaa gcgttctgct gttgtgtcat ctttaaaagt cacagccgat gaatcccagc 1547401 aagatgtcct aaaatacttg aacacccaga aagataaagg aaatgcagac caaattcatt 1547461 cttattatgt ggtgaacggg attgctgttc atgcctcaaa agaggttatg gaaaaagtgg 1547521 tgcagtttcc cgaagtggaa aaggtgcttc ctaatgagaa acggcagctt tttaagtcat 1547581 cctccccatt taatatgaaa aaagcacaga aagctattaa agcaactgac ggtgtggaat 1547641 ggaatgtaga ccaaatcgat gccccaaaag cttgggcact tggatatgat ggaactggca 1547701 cggttgttgc gtccattgat accggggtgg aatggaatca tccggcatta aaagagaaat 1547761 atcgcggata taatccggaa aatcctaatg agcctgaaaa tgaaatgaac tggtatgatg 1547821 ccgtagcagg cgaggcaagc ccttatgatg atttggctca tggaacccac gtgacaggca 1547881 cgatggtggg ctctgaacct gatggaacaa atcaaatcgg tgtagcacct ggcgcaaaat 1547941 ggattgctgt taaagcgttc tctgaagatg gcggcactga tgctgacatt ttggaagctg 1548001 gtgaatgggt tttagcacca aaggacgcgg aaggaaatcc ccacccggaa atggctcctg 1548061 atgttgtcaa taactcatgg ggagggggct ctggacttga tgaatggtac agagacatgg 1548121 tcaatgcctg gcgtgcggcc gatattttcc ctgagttttc agcggggaat acggatctct 1548181 ttattcccgg cgggcctggt tctatcgcaa atccggcaaa ctatccagaa tcgtttgcaa 1548241 ctggagcgac tgatatcaat aaaaagctcg ctgacttttc tcttcaaggg ccatctccat 1548301 atgatgaaat aaagccggaa atatctgcac cgggcgttaa tattcgttca tccgttcccg 1548361 gtcagacata tgaggatggt tgggacggca catcaatggc agggccgcat gtatccgctg 1548421 ttgctgcact gctgaaacag gcgaatgcct cactttctgt tgatgagatg gaggatatat 1548481 taaccagcac ggctgaaccg ctcacggatt caacatttcc tgattcaccg aataacggat 1548541 atggccatgg tctggtgaat gcttttgatg ctgtatccgc tgttacagat ggattaggga 1548601 aagcggaagg acaagtttct gtagaggggg atgaccaaga gcctcctgtc tatcagcatg 1548661 agaaagtaac tgaagcttat gaaggtggca gcctaccact gactttgaca gctgaagaca 1548721 atgtgagtgt gacatctgta aagctgtcct acaagcttga tcaaggtgaa tggacagaaa 1548781 taacggctaa acgaatcagc ggtgatcatc taaaaggaac gtatcaggca gagatcccag 1548841 atataaaagg aactaaacta agctataagt ggatgattca cgattttggc ggtcatgtcg 1548901 tttcgtctga cgtatacgat gtaacagtga aaccaagcat cacggcggga tataagcagg 1548961 actttgaaac tgcacccggc ggctgggttg cgagcggaac aaataataac tgggaatggg 1549021 gagttccgtc aactggccca aatacagcag catccggaga aaaagtatat ggaacgaatt 1549081 tgacaggaaa ttatgccaac tcagcaaaca tgaaccttgt tatgcctcct attaaagcac 1549141 ctgattcagg aagtctgttc cttcaattta aaagctggca caatttagag gatgattttg 1549201 attacggcta cgtttttgtt cttccggaag gtgaaaagaa ttgggagcag gctggtgtct 1549261 ataacggaaa gacatcaagc tggacggacg aagaaattga tttatcggct tataaaggcc 1549321 aaaacattca agtgatgttt aaccttcaat ctgatgaaag cattgcaaaa gagggctggt 1549381 atattgatga tgtagtgctt tctgacaaat cagccggaaa aacagtcaaa aagaataagc 1549441 tgggcgtcga aaagccgtct ggaaagcaaa agaaaaagcc agtaaatccg aaaaaggcta 1549501 agccatctgc aaacacagcg gtaaaacatc agaacaaggc tatacagcct caagttttgc 1549561 cgctcaaggc acaagtcagt gtagtggaaa caggaaaatc aacatattca gatcaatcca 1549621 cagggcagta cacgctgaag cacaaagcgg gagactatac gcttatggca gaagcatatg 1549681 gttatcagtc gaaaacacaa aaagtatctt taaagacgga tcagacgaca caagctaatt 1549741 ttacgttaga agagatgaag aagggcacat taaaaggcac ggtcatcaat aaaacgacag 1549801 gagagccggt aacaggcgct tccgtttatg ttgtagagga tgctgcggtg gaaccggcta 1549861 tgacaaacga caaaggtgaa tatatgctgg aggcctatga aggcgcttat acgattaaag 1549921 tcgctgcacc gggttattac agtgatgaat tttccgttga gttaaaaggt gatgttacaa 1549981 aagaaactgc attgaagcct ttcgtcggtt atccgggtga aattgcatat gatgacggaa 1550041 cagcggagaa tgccaattcc tattttgctg ccggtaacgg atgggcggta aaaatgacgc 1550101 tcgctgacgg caaggacaaa ggcatgctta caggagggct gttcagattc tgggatacag 1550161 agttccctga tccgggcggc acagagttta aggttgaggt atacgatgcc acaggaaaag 1550221 acggagcacc gggcaagaaa attgcagggc catttaacgc ggaagctctt cgcaatggcg 1550281 agtggactaa ggtagatctc agttcaaaag ggattatggt cgataaagat ttttatctcg 1550341 tatatatcca gtcgaaacct gatccgtatt cacctggatt ggcaatggat gaaaccggcc 1550401 agaattccgg ccgcaactgg cagtatatag atggaaagtg gcagccaggt gacaaagcgg 1550461 atggcaacta tatgattcgc gcattagttg attatgaagc tgctgtacct gagattactt 1550521 caccgacaga caaatcatac acaaataagg atagcgtcac tgtaaaagga aacgcttctc 1550581 ctggcacaac ggtacacatt tataatggag agaaagaagc aggagaaacg aaagctgctg 1550641 cggatggcac gttccatgca ggcatcatac tcaacaaggg tgaaaatgag ctgacggcaa 1550701 ctgcatcaac tgacaacgga acaacagatg cctccagccc aatcacggtc acgcttgatc 1550761 aagaaaagcc tgaattaaca ctggacaatc caaaggatgg cgggaaaaca aataaagaaa 1550821 cgctgactgt caaaggggct gtatccgatg acaatctgaa agacgtcaag gtgaatggca 1550881 aaaaagcaac agtagctgat ggttcatact cagcccgtat tcttttggaa aatggaagaa 1550941 atgaaatcaa ggtaattgct acagacttgg caggcaacaa aacgacgaaa aagacagtca 1551001 ttgatgtgaa ctttgacaag cctgtcattt ccggcttaat tccgggagag gataaaaact 1551061 taaaagccgg tgaatctgtg aaaatcgctt tctcaagcgc tgaggattta gatgcaacgt 1551121 ttaccattcg tatgccgctg accaatgcaa gagcgagtgt gcaaaatgcc accgaactcc 1551181 cgttaagaga aatctctccg gggagatatg aaggctattg gactgccact tcttctatta 1551241 aagcaaaagg agcaaaagta gaagtgatcg tccgagatga ttatggaaat gaaacaagaa 1551301 aaactgcgaa tggaaaactt aatatgaaca cagaaaatta agtggaaaaa aagctgccgt 1551361 cattggcagc tttttttata tcctctcatt atacttcctc gacaaattaa gcagatttcc 1551421 ctgaaaaatt gtattttcct ctcaacatta attgacagac tttcccacag agcttgcttt 1551481 atacttatga agcaagaagg ggaacagcgt gaggcaagaa agaaaggagt cagatgtgaa 1551541 aatctattta gatgtcattt ggctgttaaa cttttgtttt gatgcacttt tgcttttgct 1551601 cacggcattt attttaaaac ggcatgtaaa aaaaagaaga ctggtaggcg gagcgttcat 1551661 cggttccagt attgtccttt tgatgtttac tcctttttcg ccgattgttg aacatccggc 1551721 tgggaagcta gctttttcag ttgtgattgt ggtggtgaca tttggcttta aaagatttcg 1551781 gtttttcttt caaaatttgt tttcctttta ttttgccact tttttaatgg ggggaggaat 1551841 tatcggagcc cattctttgc tgcagtcaaa ttctattgtt caaaacggtg tcatgattac 1551901 caatcaaaca gggtttggag acccgatcag ctggttgttt attgttggtg gctttccagc 1551961 attatggttt ttttctaaaa gaagaattga agatattgaa acaaaaaaca ttcaatatga 1552021 ggaacgagtc agcgtgcagg cagatttggg cagccaaaca cttcatgtca gaggcctgat 1552081 tgattccggt aaccagctgt acgatcctct tacaaaaaca ccggtaatga tcatttacat 1552141 tgataaactg gagccgattt tcggaacagc cgaaacgatg atcattcgaa acacagaccc 1552201 attggaagcc atcgaacagc tcgatgattc ctttcgcttt ttagataaaa tgaggttgat 1552261 tccatacagg ggagttggtc agcaaaatca atttttatta tgcgttaaac cggatcacgt 1552321 aacgattatg acaaaagaag aaatgatttc tgcagataaa tgtttaatcg gtatcagcac 1552381 aacaaagctg tcggcagatg gagagtttga cgcgattatt catccgaaaa tgctttcggg 1552441 caaggctgtc aaacacgttt cataatgttc gcaaatgtcc gttacttatc atactcaaac 1552501 ggcgtgacat ttagaaggga gaggaagatg aaaaaactga aattacggtt gacgcacctc 1552561 tggtataagc tgctgatgaa acttgggctg aaaagtgatg aagtctatta cataggcggg 1552621 agtgaagccc tgccgcctcc attatctaaa gatgaggagc aggttttgtt aatgaagctc 1552681 ccaaacggcg atcaggcggc gcgcgccatt ctaattgaac gcaatttgcg tctggtcgta 1552741 tatatcgccc gtaaatttga aaatacggga attaatatag aggatttaat cagcatcggt 1552801 accatcggtc taatcaaagc tgttaataca tttaatccag aaaagaaaat caagcttgct 1552861 acctatgcct cccggtgtat agaaaatgaa atcctgatgt atttaagaag aaataacaaa 1552921 atccgttcag aggtttcctt tgatgaaccg cttaatattg attgggacgg caatgagctt 1552981 ttgctttctg atgtgctcgg cactgacgat gacatcatca ctaaagacat agaagctaac 1553041 gtcgataaaa agcttttgaa aaaagcgctt gaacagctta atgagagaga aaagcaaatc 1553101 atggagctgc ggtttgggct tgtcggtgaa gaagaaaaaa cccaaaagga tgtagcggat 1553161 atgatgggga tttctcagtc ttatatttcg cggcttgaga aaagaattat aaaaaggttg 1553221 agaaaagagt tcaacaaaat ggtgtaaaaa attttatggt tagaacccct tgattttaca 1553281 gggatttcct gatttcgaca gtttttcggt ctgagtgcag tgcatatttt tcccacccaa 1553341 ggagatactt aacgttgtac agcagctcct gtagggaggg aaaaaagtgt cgagaaataa 1553401 agtcgaaatc tgcggggtgg atacctccaa attaccagta ctcaagaatg aagagatgag 1553461 aaagctgttt aggcagctgc aggatgaagg cgatgattca gcaagagaaa agcttgtaaa 1553521 cgggaacttg cgtcttgtct taagtgtcat tcaacgattt aataacagag gggagtatgt 1553581 tgatgactta tttcaagtcg gctgcatcgg actaatgaaa tccattgata attttgacct 1553641 aagccacaat gttaagtttt caacatacgc tgtacctatg attatcggag agatccgcag 1553701 gtatttacgt gataataacc cgatccgtgt ctcaagatca ctccgggaca tcgcttacaa 1553761 ggcgcttcag gtaagagagc ggttaatcag tgagacaagc aaggagccga ctgcagaaga 1553821 catcgcaaaa gttcttgaag taccgcatga ggaaattgta tttgcgcttg atgccattca 1553881 ggatccggtt tctctatttg aaccgatcta taacgacggc ggagacccga tctatgtgat 1553941 ggaccaaatc agtgatgagc gtaatacaga ttcacaatgg attgaagagc tggctttaaa 1554001 agagggcatg agaaggctga acgataggga aaaaatgatt ttgagaaagc gattcttcca 1554061 agggaaaacc caaatggaag tcgccgagga aatcggaatt tctcaagcgc aggtgtccag 1554121 acttgaaaaa gcggctatca aacaaatgaa taaaaatatt catcaataat gaaaagcctt 1554181 taaaacgatg ttgttttaaa ggcttttcta ttgattatgg atggtttacg ttttggaaaa 1554241 agtaaggtat cctagttcgt acaaagtttt atgaaaatta aaacaattat aaaaggcaat 1554301 aaagaggagg accacgatga ttttgcagct tgacaatgtc tcactaaaac ggaatgggaa 1554361 atggatactg aaagatattc attggaaggt ggaagaaaag gaaaattggg tgctttacgg 1554421 cctaaatggc gccgggaaga cagcgctgtt aaatatgctt tgctcatatt attttccaac 1554481 atcaggcgag atgcaggtgc tcggccatga atttggcaaa acagagcttg gggaaaagct 1554541 cagacgtaaa attggcctcg tctcagcagc tcttcagcaa aaattgtatc cggcagattc 1554601 agcttttgaa attgctttga gcggagctta cgcttcgatt gggttatatg aaacgccaag 1554661 taaggaaacc agggaaaaag cgataggttt gttagaggac ttgggagcaa ttgaatatgc 1554721 cgatcgccgc tatgaaaccc tttctcaagg ggaaaaacaa agagcattga ttgctagagc 1554781 actaatggcc gatccggagc tgctgatact ggatgaacca gtcacaggac tggattttat 1554841 tgcccgggaa aagctgttag atacgattac atacattgca aacaaagaaa atgcaccatc 1554901 tatcctttat gtgactcatc atgctgaaga aattttgcct gtctttgata aagccctttt 1554961 attaaaacag ggagaggttt ttggatccgg agaaataaag gaaatgctta ctgatcaaat 1555021 actttccgct ttttttgata cgccaatcca tgtattatgg aatcaggatc ggccgttttt 1555081 aacaagagct gagccgataa cgaatgcctg acaaatatat atagattcat cctaggggtg 1555141 ctttgcgaag ctgagagaga ctttgtctca acccttttga cctgatctgg atcatgccag 1555201 cggagggaag cggtgaaaag cggagtacat cggactccgt ttgtttttat taagccgttt 1555261 catcacattt gaaacggctt ttttgatttt aaagaatagg agcggattta cattggatca 1555321 acaaatatac tctttgcaaa aaaaagtgga agaacataag gaggagctta ttcagcttgc 1555381 gaaaacgctg atttcttatc aaacacctgc tccgcctgca agaaatacag agggcattca 1555441 gtcttggatt gcgggatatt taaatgaatt gggattctcg atcgacaaat gggatgtgta 1555501 ccctggagat cccaatgttg tagggaagct aaaaggaaca gattcagcag attattatag 1555561 cctgattatc aatggccatg tagatgtggc agaggtaaaa gaggatgaag aatggaagca 1555621 cgatccgttt catcccattg aaaaaaacgg tctcttaatc gggcgaggcg cttccgatat 1555681 gaagggcgga atggcttgtg tgctgtttgc tgtcaaatta attcgtgaag caagcattga 1555741 acttccaggt gatctgattc tgcaatcggt tattggggag gaagttggag aggccggcac 1555801 acttgaatgc tgcaagaggg gctaccacgc tgattttgca attgtcgcgg atacgagcga 1555861 tatgcatatt caaggccaag gcggtgtcat tacaggctgg atcgaaatca aaagcagtca 1555921 aacatttcat gatggaacga gacggaatat gattcatgca ggcggaggaa cattcggagc 1555981 aagcgcaatt gaaaaaatgg caaaaatcat tgcggggctc ggtgaacttg agcgccactg 1556041 gtctattatg aaaagttatc ccggttttaa accaggcaca aatacgatta acccggcagt 1556101 tatagaaggc ggcagacatg cggcttttat agcggacgaa tgccggctgt ggatcacagt 1556161 ccatttttat ccgaatgaaa cccatgacca agtggcagcg gaaatagaag attacgtcaa 1556221 tcggctgagt gacagtgata tttggcttag ggaaaaccgc cctgtattca agtggggagg 1556281 ctcatctatg atagaagaca ggggagaaat ttttccggca ttggaagttg accctggcca 1556341 cccaggcgtc ttagcgctaa ctgcctctca tcagaaagtg aaacgggagt gtccaattat 1556401 tgacgtttct caatcagtta cagatggcgg atggctgtat gatgccggta ttccatgcgt 1556461 aatatacggt cctggagatc tgcacaatgc acactctgtg aacgagaagg tatcgattga 1556521 gcagctagta gagtatacaa aaattatact cgattttatc atcagctggt gcagccggaa 1556581 aaaagaacaa tgacatgaaa atttcttctt gctgacaagg ttcagcctgc ccgttcatat 1556641 acttgaacaa aaggacggaa aaaggacgtg atggaatgat cagcatttca gaatttcagg 1556701 taaaggatgt cgtcaatgtc tcaaacggaa aaaagctggg gagtattggt gatattgata 1556761 tcaatgtgac cactggaaaa attcaggcga tcatactcgg aggaaatggg aaagttctcg 1556821 gattttttgg aaaagaagag gaattggtca ttccatggcg aaatatagta aaaatcgggg 1556881 aagatgtaat cttagtccga ttaagtgaac cacatgcata aacctgcttg tctgccgcag 1556941 attggcaaat gccggaagtc tcgattcttc cggcacattt catttagaaa tatgcaaatc 1557001 ggcgctcaac gaatgcagta agatgtggta aaataagtgg gaaattccgc ttttttaaat 1557061 gtttgtcgaa aggttggatc atcatgaata catatcaccc attcagtctt accacaccct 1557121 cgacactcat gatacaagac tgggctcaaa cgaatcaaaa caacaaagag gtcattgccg 1557181 gatttacgac aaaaaacggc ggtgtcagcc aaaagccttt tgaatcgtta aatacaggat 1557241 tgcacgttca tgacaaagat gcagatgtag ttaaaaatcg tgaatatatt gccgatatgt 1557301 ttaatactga tttgcagtct tgggtattcg ctgatcagac acatgataat cgcgttcaga 1557361 aagtgacgca gagggatagg ggaaaaggcg cccgtgagta tcacacggct ctaaaagcaa 1557421 cggacgggat ctatacaaat gaaaaaaatg tatttttagc attatgcttt gctgattgtg 1557481 tgcctctttt cttttatgat ccggttaagt cgcttgtcgg agtcgcccat gccgggtgga 1557541 aaggcaccgt caaacagatt ggcagagaaa tggtgaagca atggactgag aaggaaggtt 1557601 caaatccctc agatatttac gctgttattg gcccgtctat cagcggagca tgctatacgg 1557661 tagacgaccg cgtcatggat gctgtccgcg cattgccggt ttcagcagac cttgccgcca 1557721 atcagacggc aaaggcacaa tatcagcttg atctgaaaga gctgaaccgt cttatactga 1557781 tggacagcgg tttggcaagt gaacaaattt ctgtcagcgg tttatgcacg gaaagcgagc 1557841 cgtctctttt ctattctcat cgccgcgatc aggggaaaac tggacggatg atgtccttta 1557901 tcggaatgaa ggaggcataa aagatcttgc gtgttgttga taatttacga catataaacg 1557961 aacgaataaa cgaagcatgt aacagatcgg gccgcagctc cgatgaagtt acggttattg 1558021 cagtcacaaa atatgtatca cctgaaagag cacaggaggc agtagatgct ggcatcacct 1558081 gcctcggaga gaatcgggat gcggaactgc tccgcaaaca ggaattgatg aaagggaatc 1558141 cggaatggca ttttatcggc agtctgcaat caagaaaagc aaaatctgtc gtcaattcgg 1558201 tttcctatat ccattcccta gaccggctct cattagcgaa agaaattgaa aaacgggctg 1558261 aaggtactgt acgatgcttt gtgcaggtca atacctctct tgagccttct aaacatggca 1558321 tgaaaaaaga agaagtcatt ccattcatac aggagctttc cggtttcgaa catatccttg 1558381 ttgccgggct gatgacaatg gctccgctga ctgatgatca agatcagatc agaagctgtt 1558441 tcaggtcgct gagagaactc cgtgaccagg ttcagaagct gaaccagccg aacgctccgt 1558501 gtactgaact gtcgatgggc atgtcaaatg attttgaaat tgcaattgaa gaaggagcta 1558561 cttatattag aatcggctca tcgttagtcg gaaatgaaac agggggtgta cagcaatgag 1558621 tatgaaaaat aaactgaaaa actttttctc aatggaagat gaagaatacg aatatgaata 1558681 tattgagaca gagcgggaat ctcatgagga gcatgagcaa aaagaaaagc cggcttacaa 1558741 cgggaataaa cctgcgggca aacagaatgt agtgagcttg caaagtgttc agaaatcctc 1558801 taaagtggtg ttgagtgagc cgcgcgttta tgcggaggcg caggaaatag ccgaccattt 1558861 gaagaaccgg cgggcagttg tcgtcaatct tcagcggata cagcatgacc aggcgaagcg 1558921 gattgttgac tttttaagcg gaaccgttta tgccattggc ggcgatattc aaagaatcgg 1558981 ctcagatatt ttcctctgca cgcctgacaa cgtagatgta tcaggcacaa tttctgagct 1559041 catatctgaa gacgaacatc agaggtggta aagcgagatg atcctttatc aagttttttc 1559101 ggttttaagc ttattaatca caatatactc atttgccctg atcatatata tttttatgtc 1559161 atgggtgccg agtacgaggg aaacagcagt cgggcgtttt ttggcttcga tttgtgaacc 1559221 atatctcgaa ccattcagaa aaatcatccc tccgattgca atgctggata tttcaccaat 1559281 cgtagcaata cttgtgcttc ggtttgcgac aaccggcttg tggggacttt atcgcatgat 1559341 tgcgttttaa tgtgacagtt tgataggggc ttggcagcag ccaagcctct ttacatagaa 1559401 gggaaagacg atgagcgata tatatcagca cttcagaaaa gacgagcggg cctttattga 1559461 tcaagcgctc gaatggaaaa gaattgtcca ggagcagtac cggatgaagc tgaccgactt 1559521 tttagatccc cgagagcagg tcatcctctc tgctgttacg ggacaggcag atgtcgggct 1559581 tgccttttcc ggcggctatg acagagcgga gcggaaacgg gcgattctgt ttccagagta 1559641 cattactccg gaagaatcag attttgaact gcaggcgttt aacgtccgtt atgctgacaa 1559701 gtttgtctca gtagatcatc gttctctgct tggtgcatta atgggcatag gattaaagcg 1559761 gcaaaaattc ggtgacatcg tgttttctga gacagcagtg caattgattg tctcagccga 1559821 taccgctgat tttgtggctg cacagctgac ccaagcaggc aaagcggcgg tcagcctaga 1559881 gaaaatcgac ttgtcagacc ttaacattcc agcagttgat gtcgaaataa gagatgacac 1559941 ggtttcttct ttaaggcttg acgccgtctg cgcctctatg agcaggcaat cccgccagaa 1560001 atcacagacg cttgtgaaaa acggccttgt gaaagtgaac tggaaggtgg ttgaagatcc 1560061 ttcatacata gtcgcggaag gggacatgct gtctatcaga ggttttggcc ggtgcagctt 1560121 aacaaaaatc gaaggaaaaa ccaaaaaaga caaatggaga gttacgtttg aacgacaaaa 1560181 atagtcggtt tttcagtttt tttctccatc tgtgcgaaat ttgttttata atgtgaacta 1560241 gataaccgta ctgaaatgta aaaatggagg tggcatcatg ccattaacgc caaatgatat 1560301 tcacaacaag acgtttacaa aaagttttcg cggatatgat gaagatgaag taaatgaatt 1560361 cctagcccaa gtcagaaaag attacgaaat tgttctccgc aagaaaactg agcttgaagc 1560421 gaaagtcaat gagcttgatg aaagaatcgg acactttgcc aatattgagg agacattgaa 1560481 taaatcaatt ttagttgctc aagaagcggc tgaagacgta aaacgcaatt ctcaaaaaga 1560541 agcaaagctg atcgttcggg aagcggagaa aaacgctgat cgcattatca acgaatcgtt 1560601 atcaaaatca agaaaaattg caatggaaat tgaagagctg aaaaaacagt ctaaagtgtt 1560661 cagaacacgt ttccaaatgc tgattgaagc tcagcttgat cttctgaaaa atgacgattg 1560721 ggatcatctc cttgagtatg aagtcgacgc tgtatttgag gaaaaggaat aaattctctg 1560781 attatcttga cattttctta gcttgtcgaa tataatacgt tcataaattc agatgaaaaa 1560841 acggttgaaa gggacagtca tgtttccttc aggccttcat agcgacccgg agatggtgag 1560901 agtccgggat ggccggaatc atgtagatca gccctttagt ttccttgctg aactcacagt 1560961 aggttaggac gttcatcacg ttacgatgct caagaggaaa aagtgtatgc ttgctttttc 1561021 taaaagggtg gtaccgcgag ataagctttc tcgtccctta tgggatgaga gggctttttt 1561081 tattttctga aaaaatgcag tggaggaatg aaaatggatt ttaaagacac gctcttaatg 1561141 ccgaaaacag atttcccgat gcgtggaaat ttgccaaacc gtgagcctga cattcaaaaa 1561201 aaatgggagg aagaagatat ctaccgtctt gttcaggaac ggacgaaaga ccgcccgaaa 1561261 tttgttttac atgacggacc tccgtatgca aacggcgaca tccatatggg ccatgcactt 1561321 aacaagattt tgaaagactt cattgtccgc tataaatcaa tgagcggcta caacgcaccg 1561381 tatgtgccgg gctgggatac acacggattg ccaattgaaa cagctctgac aaaaaacaaa 1561441 aaggtcaacc gcaaagaaat gtcagtagcg gaattccgca aactatgcga agagtacgct 1561501 tggaagcaaa tcgagggaca gcgtgagcaa ttcaaacgtc ttggtgtccg cggtgactgg 1561561 gaaaacccat atgtgacatt aaaaccggaa tacgaagcgc agcaaatccg cgtatttggt 1561621 gaaatggcaa aacgaggcta catttacaaa ggccttaaac cggttaactg gtcaccttca 1561681 agtgagtctg ctctggctga agccgagatc gaatatcaag ataaacgttc agcatctatt 1561741 tacgtcgctt ttggtgtaaa agacggaaaa ggcgttcttg aaaacggcga gcgcatcatc 1561801 atttggacaa caacgccgtg gacaattccg gcgaacctcg gaatctcagt gcaccctgat 1561861 cttgagtaca gcgtgattgc agtaggtgaa gaccgctttg ttgtagcaag tgccttagtc 1561921 gaaaatgttg catcggcatg cggatttgat cagtatgaag tgacaagaac ggtcaaaggg 1561981 aaagaccttg agaacattat cgctgaacac ccgctatatg gcagagactc tctcgttatg 1562041 cttggtgaac acgtaacaac tgatgccgga acaggctgtg ttcatacagc gcctggacat 1562101 ggggaagatg actttatcat cggccaaaaa tacggtttag atgtgctttg cccggtcgat 1562161 gaaaaaggtg taatgacaag cgaagctcct ggctttgaag gcatgttcta tgatgatgca 1562221 aacaaagcga tcacacagca gcttgatgaa aaaggcgcac ttgtgaagct tgaattcatt 1562281 actcattctt atccgcatga ttggagaaca aaaaaaccaa ccattttcag agcaacagcg 1562341 caatggtttg cgtctattaa agatttcaga tcagacctgc tggatgccat taaagaaacc 1562401 aaatgggttc ctgaatgggg cgagcagcgt ttgcacaaca tggttcggga ccgcggagac 1562461 tggtgtattt ccagacagcg tgcgtggggt gtgccgattc cggtatttta cgctgaaaac 1562521 ggagaaccgg ttattacaga tgaaaccatt gaacatgttt ctgaattgtt cagacagcat 1562581 ggatcaaaca tttggtttga aaaagaagca aaggatcttc ttccggaagg ctttacgcat 1562641 cctggcagcc cgaacggcac atttacaaaa gaacaggata tcatggatgt ttggtttgat 1562701 tcaggctctt cacatcaagc agtgcttgaa gaacgtgatg acctcgttcg cccggctgat 1562761 ctatacctag agggatctga ccaatatcgc ggctggttta actcttctct ttctacagca 1562821 gtagccgtaa cagggaaagc gccgtataaa ggtgtgctca gccatgggtt cgcactggat 1562881 ggagaaggac gtaagatgag taaatcaatc ggtaacgttg ttgttccggc taaagtcatg 1562941 aaacagcttg gtgccgacat cttaagatta tgggtatctt cagtggatta tcaggcggac 1563001 gttcgcgtgt ctgacgccat tctgaagcag gttgcggaag tatatcgtaa aatccgcaac 1563061 acgttccgtt tccttcacgg caaccttttc gattttgatc caaaaacaaa tgcggtggct 1563121 gtcgaagatc ttcgcgaagt ggatcagtat atgctgatta agctgaacaa gctgattgat 1563181 aaagtgaaaa aagcgtatga tgagtacgaa tttgcggttg tgtatcacag cattcataat 1563241 ttctgcacaa tcgaattgag ctcattctac cttgattttg caaaagatat tgtctacatc 1563301 gagcatgcgg atcatccgga tagacgcagc atgcagacag tattctacga aacgcttctt 1563361 gcattagtga agctttcagc gcctatcctt ccacatacgg cagacgaatt gtggtctcat 1563421 ttaacatttg ttgaagagca gagcgttcag ttgaccgata tgccggaaac aatcacggtt 1563481 ccaaacagtg aagcgactga agaaaaattt gaccgcttta tggctcttcg tgatgacgtg 1563541 ttaaaagcat tagaaactgc gcgaaatgaa aaaattatcg gtaaatcttt ggaagcaaac 1563601 ctgaaattgt atccaaacaa agaaaacaag gagctcttgg cttccataaa agaaaacctt 1563661 tctcagctgt ttattgtgtc tgaactgaca atcagcgaag aaaatgaagc gccgaacgat 1563721 gcgcaaagct ttgcgacggg taaaatcgct gtcgagaaag cggaaggcga aatgtgtgag 1563781 agatctcgtg tgatttcaaa agatgtaggg gcaaatccga aatatcctac actttcatta 1563841 cgcaacgctg aaatcgttga aaaatactat caaaaataat gcaaaagagc ccggcgtaaa 1563901 agccgggctt tttttgtgcc aagagtgaca tcctttagaa cgaaaggaaa aatcttatgg 1563961 gctttagatc atcattcaca ggcaacaata aagatactac gttaagagca ggagttgtga 1564021 agaatgaatg atcaactgac cgcaatttat acggaacttc ttctgatgaa agaagaatta 1564081 cagtcgagat tatttgagta ttcttgcttt caggtttcta caagcccgca agcagcaatc 1564141 aatcaaaaac aaaaagcaac tctgatctat catattaaag aagaacttca agacgttctc 1564201 cttgcattgt ccaaaatcga aaacggcaca ttcggatact gtgaagaaac tggggccccc 1564261 attcctcttg caaagctggc agtgctgccg acggcccgaa cagcaaacga ttttctttat 1564321 tctgtccaat ttgagaaaaa aacgcttccg atatggaaat caacggatat cgaatatggt 1564381 caggcactgt atgaataaca gtgtctgtcc ggttaatatg cctgatattt ctttactcca 1564441 gtgcttttta ttgataaaat gcataatgga ttaaagtaac cgtaaactgg aggaacgttt 1564501 gtgctgtatt atatgattgc actacttatt attgcagccg atcaattgac aaaatggcta 1564561 gttgttaaga acatggaact tggccaaagc attccgatca ttgatcaggt attctatatc 1564621 acctcccatc gcaatacggg tgctgcatgg gggatattag cgggtcaaat gtggtttttc 1564681 tacctcataa caaccgctgt tattattggt attgtttatt acatacagcg ttatacaaag 1564741 ggacaaaggc ttcttggcgt tgccctcgga cttatgcttg gcggtgccat cggcaacttt 1564801 atcgatcggg ctgtcagaca ggaagttgtg gattttatcc atgttattat tgtcaattac 1564861 aattacccga tatttaacat cgcggactct tcactatgtg tcggcgtaat gcttttattt 1564921 atacaaatgc tgttggacag cgggaaaaag aaaaaggagc aatagcatga atcaaattga 1564981 tataaccgct tcagaagaac aaaaaagtga gcggattgat aaatttttgg catcgactga 1565041 gaatgattgg tcaagaaccc aggttcagca atgggtaaaa gacggacagg ttgtcgtgaa 1565101 cggaagcgcg gtgaaagcga attataaaat tcagccgggt gatcaggtga ccgtcactgt 1565161 acctgaaccg gaagcgctcg acgtcctggc agagcctatg gatctggata tttattatga 1565221 ggaccaggat gtgctggtcg tcaacaaacc tcgcggaatg gttgttcacc cagcacccgg 1565281 gcatcttacg ggcacacttg taaacggtct tatggctcat tgcacagacc tttccggaat 1565341 aaatggtgtg atgcgcccgg gtattgttca cagaatcgat aaggacacgt ccggtttatt 1565401 aatggtggcg aaaaatgata tggcgcacga gtcactcgta aaccaattgg tcaacaaaac 1565461 ggtcacgcgg aaatatacgg cggttgtcca cgggcttatt tctcatgatg acggcacaat 1565521 tgacgcgccg atcggacggg ataaaaaaga ccgtcaaagc atgactgtga cacgtgatgg 1565581 caaaaacgct gtcactcatt ttcatgtgct tgagcgtttt caggatttta cgttagtgga 1565641 gtgccagctt gaaacaggga gaacccatca aattcgtgtt catatgaaat atatcggatt 1565701 cccattagca ggcgatccga aatacggccc aagaaaaaca atcgacttta atggccaagc 1565761 gcttcacgcg ggagttttag gttttgacca tccacgaaca ggagaatatg tcgaatttga 1565821 agcgccgctt cccgaggata tggcagaatt aatcgaaaac ctcagaaaaa acggttgaca 1565881 gagggtttct tttctgaaat aataaacgaa gctgaataga ttctttaaaa cagtccagag 1565941 aggctgagaa ggataacgga tagacgggat gcgtgtatag gcgcgcacct tgtcctaaaa 1566001 cccctctatg ctctggcagg aggggttttt tcttctatat gaactgtgag gtgtcacaca 1566061 ttgaatcaaa aagctgtcat tctcgacgaa caggcaatta gacgggcgct gaccaggatt 1566121 gctcacgaaa tgatcgaacg caataaagga atgaataact gcattcttgt cggcattaag 1566181 acaagaggga tttacctggc aaaacgcctt gcggaacgca ttgaacagat tgagggaaat 1566241 cctgttacag tcggtgaaat tgatattact ctttacagag atgatctttc taaaaaaaca 1566301 agcaacgatg aaccgcttgt aaaaggtgca gatattccgg tagatattac agatcaaaaa 1566361 gtcattctcg ttgatgatgt tctgtatacc ggaagaacag tcagagcagg aatggatgcg 1566421 cttgttgatg taggcagacc ttcctccatt cagcttgcag tgcttgtgga cagaggacac 1566481 cgggagctgc cgatccgagc ggattatatc gggaaaaaca tcccgacatc aaagtctgaa 1566541 aaggttatgg tacagcttga tgaggtagac caaaacgatc tcgtcgccat ttatgaaaac 1566601 gaataataga tcaccttttt aagggcaatc cagagaggtt gcaaagaggt gcacaacaaa 1566661 ggcccaaaaa gtattcggca ggtctttgta tgcctctttg cgtaaaaaag caaagaggtt 1566721 tttttataca gtcattgagt catcctaaaa tgaaagtcaa caatcagggg gaaatcatca 1566781 tgagtaagaa aaaagtaaat ttaggggtca gggatgtccc gacacctttc tcttgggttt 1566841 cattcagcct tcagcatttg tttgccatgt ttggctcaac cattttggtt ccgaagctcg 1566901 tcggaatgag tcctgctgtg gcgttggtga caagcggcat cggaacactg gcgtaccttc 1566961 ttattaccaa aggacaaatt ccggcgtatc tcggttcatc cttcgccttt atttctccga 1567021 tcattctggt aaaagcgacc ggcgggccgg gagcggcaat ggttggagcg tttcttgcag 1567081 ggctggtgta cgggctgatt gccttattga ttaggcagct tggaacagga tggctgatga 1567141 agattctccc gcctgtagtc gtagggcctg ttattatcgt catcgggctg ggactggcaa 1567201 gcactgcagt aaacatggcg atgtatgctg atccgaacgc gagtgagttg gtctacagct 1567261 taaagcactt tagtgtcgca ggagttacgc tggcaattac gattatttgt gcgattttct 1567321 tacgagggtt tttaagcctg attccggttc tgatcggaat catcggcgga tacctgtttg 1567381 cccttactca agggattgtc aacttccagc cggtgcttga cgcgaaatgg tttgcagtgc 1567441 ctgaatttat cattccgttc aaagattatt caccgtcagt tacgctcggc atcgcagccg 1567501 caatggttcc tgtcgcattt gtcacaatgt cagagcatat cggccaccaa atggtgctga 1567561 gcaaggttgt cggacaagac ttcattaaaa agccaggtct tcatcgctct attatgggtg 1567621 acagtgtggc gacaatcctc gcttccctga tcggcggccc tccgacaacg acttacggag 1567681 aaaacattgg cgtgctggcc atcacaagag tattcagcgt ctttgtcatc gggggcgcgg 1567741 cagtgattgc cctttgcttc ggctttatcg gcaaaatttc agcgctgatc agttcagtgc 1567801 cgtcagcggt catgggaggc gtctccttcc tgctgttcgg aatcattgct tcaagcggcc 1567861 tgagaatgct gattgacaac aaaattgatt atgaaaacaa cagaaacctc attattacat 1567921 cagttatcct tgtcatcggt gtaggaggcg cttttatcca agtgtctcag ggcggattcc 1567981 aagtgtcagg aatggcgctt gccgcaattg tcggtgtcat cttaaacctg attcttccgc 1568041 aggcgaagga agagcaggca gacacatctg aacaacatca tatttaaaac cttttaatga 1568101 aagtccagag aggcttggaa gggttatgaa gagaaggaag cttcaatgct gccctctatt 1568161 taaccatacc ccgagtctat cttagaccgg ggtttttttt cagccttaag ttgaaaagag 1568221 aggggaaaga acatgaagca tttaacgacg atgagtgaac ttagcactga ggaaatcaaa 1568281 gatttgcttc aaacagcaca agagctcaaa agcggaaaaa cagacaatca gcttacagga 1568341 aagtttgcag caaacctgtt tttcgaaccg agcacgagaa cgcggttcag ctttgaggtc 1568401 gcagaaaaaa agctgggcat gaatgtgctt aaccttgatg gaacaagcac aagcgtgcaa 1568461 aaaggcgaaa ccttatatga cacgatccgg acgcttgaat caatcggtgt ggacgtctgc 1568521 gtcatcaggc acagtgagga tgagtattat gaagagcttg tcagccaggt gaacattccg 1568581 attctgaatg cgggagacgg gtgcggccag catccaacac aatcactgct tgatttaatg 1568641 acgatttatg aagagttcaa tacgtttaaa gggcttaccg tctccattca cggcgacatc 1568701 aagcatagca gagtggcaag gtcaaatgcg gaagtgttga caagattggg tgcccgggtc 1568761 ctattttccg gcccttcgga atggcaggat gaagaaaata cattcggcac gtatgtctca 1568821 atggatgaag cagttgagtc ttccgatgtt gtcatgctgc tgcgcattca aaatgaacga 1568881 catcagtccg ctgtcagtca ggaaggctat ttaaacaaat acggcttgac cgtagaacgg 1568941 gctgagcgta tgaagcggca tgcgatcatc atgcatcctg ctccggtaaa cagaggagtg 1569001 gagattgatg acagcttagt agaaagcgaa aaatcaagaa tcttcaagca aatgaaaaat 1569061 ggcgtattta tcagaatggc agtgatacag cgtgccttac aaaccaatgt gaaaagagga 1569121 gaagcagcgt atgtcatatc tcattaaaaa cggctggata ctaaacgaaa atggtgaaaa 1569181 aacacaagcg gatatccgag tgactggaga aaccatcacc gcaatcggca agcttgatgc 1569241 aacggataat gaaacggtaa ttgatgcaaa aggtttgctc gtttcacctg ggtttgttga 1569301 tctccacgtg catttcagag agccgggcgg agagaaaaaa gaaactattg aaaccggggc 1569361 aaaagcagcg gcgcgcggcg gctatactac agtagcagca atgccgaata cgcggccggt 1569421 tcctgataca aaggagcaga tggaatgggt gcaaaacaga attaaagaaa catcatgcgt 1569481 aagagttctt ccatatgcat ccattacgat cagacaaatc ggcgatgaaa tgacaaactt 1569541 tgaagcgtta aaagaagccg gggcatttgc ttttacagat gacggcgttg gtatacagac 1569601 agcaggaatg atgtatgaag cgatgaaacg ggcagccgca attgacaaag cgattgttgc 1569661 acattgcgag gacaactcct taatttacgg agggagcgta catgagggga cattctccaa 1569721 agcgaacggg ctaaacggca ttccttctgt gtgtgaatcg gttcatattg ctcgcgatgt 1569781 gctgctggct gaggcggcaa actgccatta tcatgtatgc catatcagca caaaagaatc 1569841 tgtcagagtt gtacgcgatg cgaaaaaagc gggaatcaga gtgacagcag aagtatcgcc 1569901 gcatcatttg ctgctttgtg atgaggacat cccggggctg gacacaaact ataaaatgaa 1569961 tcctccgctc cgcagcccag aagacagagc tgctttaatt gaaggtcttt tagacggaac 1570021 aattgatttt atcgcaacag accatgcacc gcatacggaa gaagagaaga acacagaaat 1570081 gaagctggcg ccattcggaa ttgtcggctt agaaacagca ttcccgcttc tttacacaca 1570141 ctttgtcaaa aatggcagct ggtcactgaa gcagctgatt gactacatga caatcaagcc 1570201 atgcgaagcg ttcggtctcc catatggaac attacaaacg gggcaagctg cggacattac 1570261 gttaatcgat ttagaaaaag aagcagttat agacaaagag acatttttat caaaaggaaa 1570321 aaatacacca ttcaacggca tcagttgcac cggctggccg gtcgctacaa ttgcggcagg 1570381 gaagcttgct tatgaagagg ggagacttgt caaatgaaga gacgattagt actggaaaac 1570441 ggagcggtat tcgagggaga agctttcgga agcttagaac acaacatggg agaagtcgtt 1570501 tttaatactg ggatgacagg ctatcaggaa attttatctg atccttctta ctgcggacag 1570561 atcgtaacat taacataccc gcttatcgga aattacggca ttaaccgtga tgattttgaa 1570621 tccattaccc cttttgtcaa agggctgatc atcaaagaat tatgtgagct gccttccaac 1570681 tggcgttcag catacacctt agacgagtat ttaaaaatga aaaacattcc cggactccag 1570741 ggaattgata caaggaagct gacaagaatg atccgcacgg caggcgcgct aaaaggaaca 1570801 ttcgcttcat ctgatgaaga tatcgaagca gtgctgaaaa gactgaacga aacggaattg 1570861 ccaagaaatc aagtatccca agtatcagca aaaacagcat atccgagccc gggaagaggc 1570921 aaacgcattg tcttggttga cttcggcatg aaacacggga ttctaagaga gctgaacaaa 1570981 cggaaatgtg acgtcatcgt tgtgccttac aacattacag cggaagaggt gcttcagctg 1571041 aaaccggacg gtatcatgct ttctaacgga cctggagacc cgaaggatgt gcctgaagcg 1571101 attgaaatga ttaaaggtgt tcttggaaaa gtgccattat tcggaatatg tctcggccac 1571161 caattattcg cgctggcgtg cggggcgaat actgaaaaaa tgaaattcgg ccacaggggc 1571221 tcaaaccacc cggtaaaaga gctggctaca ggaaaagttg ccttaacatc tcaaaaccat 1571281 ggatatacag tttcgtctat cagtaaaaca gaactggaag tgacgcatat cgcaattaac 1571341 gacgatacga ttgaagggct gaagcataaa acattgccgg catttacggt tcaatatcat 1571401 cccgaagcct cacctggtcc tgaggatgcc aaccatctat ttgacagatt catcgaaatg 1571461 atcgaaacaa cagagaaaga aggggaagcg gtatgccaaa acgcgtagac attaacaaaa 1571521 ttttagtaat cggatctgga ccgatcatca tcggccaagc agcagaattt gactatgcgg 1571581 gaacacaagc ctgtcttgct ttgaaagaag aaggctatga agtcatcctt gtcaactcaa 1571641 accctgcaac gatcatgaca gatacagaaa tggctgaccg ggtttacatc gaaccgctca 1571701 cacctgaatt cctgacacga atcatcagaa aagagcgccc ggatgccatt cttcctacac 1571761 tcggaggcca aaccggtttg aatcttgcgg ttgagctttc tgaaagaggc gttttggcag 1571821 aatgcggcgt cgaagtgctt ggcacgaaac tgtctgcgat tcagcaagct gaagaccgtg 1571881 acttgttcag aacattaatg aatgaactga atgaaccggt gcctgaaagt gagattatcc 1571941 actcccttga agaagcagaa aaattcgtca gtcaaattgg attccctgtc attgtccgcc 1572001 cggcatatac attaggcgga acaggcggag gcatctgctc gaatgaaaca gagctaaaag 1572061 aaatcgttga gaacggcttg aaattaagcc cggtacacca atgtctgctt gaaaaaagca 1572121 tcgccggcta taaagaaatc gagtatgaag tcatgagaga cagccaggat cacgccattg 1572181 tcgtttgtaa catggaaaac attgatccag ttggaatcca tactggagac agtattgttg 1572241 tcgcgccgag ccaaacgctc agcgatcgcg aatatcagct cttgcggaat gtatcgttaa 1572301 aactgattcg cgcgcttggg atcgaaggcg gatgtaatgt ccagctcgcc ttagatccag 1572361 acagcttcca atattacatt attgaagtaa atccgcgtgt cagccgttca tctgcccttg 1572421 catcaaaagc aacggggtac ccgattgcaa agctcgctgc taaaattgca gtcggacttt 1572481 cattagatga aatgatgaac ccggtgacag gaaaaacata tgcagcattt gaacctgctc 1572541 ttgactatgt cgtatccaaa attccgcgct ggccgtttga taagtttgaa tcagcaaaca 1572601 gaaagcttgg cacgcaaatg aaagcgacag gtgaggtcat ggcaatcggc cgcacgcttg 1572661 aagagtcatt gctgaaggca gtgcgatcac tggaagcgga tgtgtatcat cttgaattga 1572721 aggacgccgc tgacatttca gatgagcttc ttgaaaagcg aattaaaaag gccggtgatg 1572781 aacgcttatt ctacttagct gaagcgtaca gaagaggcta cacggtagaa gacctccatg 1572841 aattttccgc tatcgatgtc ttcttcttgc ataagctgtt cggaatcgta cagtttgaaa 1572901 aagaattgaa ggccaatgcg ggcgatacag atgtgctgag acgggcaaaa gaactcggct 1572961 tctctgatca gtacatcagc cgtgaatgga aaatgaaaga atctgagctt tacagcttga 1573021 gaaaacaagc ggggattgcg ccggtattca aaatggtaga tacatgcgcg gcggaatttg 1573081 agtcagaaac gccatacttc tatagcacat atgaagaaga aaatgaatct gtcgttacag 1573141 ataagaaaag tgtgatggtg cttggttcgg gtccgattcg aatcggtcag ggtgtcgagt 1573201 tcgactatgc gacggttcac tctgtatggg caattaaaca agcaggctat gaagccatta 1573261 ttgtcaacaa caacccggaa accgtttcaa cagacttcag catctcagac aagctgtatt 1573321 ttgaaccgct tacgattgaa gatgtcatgc acatcattga cctcgaacag ccaatgggcg 1573381 ttgtcgtaca atttggcgga caaactgcga ttaaccttgc tgacgagctt tctgcacgcg 1573441 gagtgaaaat ccttggaact tcattagaag atttagaccg tgccgaagac cgggataaat 1573501 ttgaacaagc gcttggagaa cttggtgttc ctcagccgct tggcaaaaca gcgacatcag 1573561 ttaatcaggc ggtaagcatc gcaagtgata tcggttatcc ggtactggta cgcccttcct 1573621 atgtacttgg cggccgggcg atggagattg tttaccatga agaggaactg cttcattaca 1573681 tgaaaaatgc agtcaaaatc aatccacagc accctgtatt aattgataga tacttgaccg 1573741 gaaaagaaat tgaagtcgat gcagtatccg acggtgaaac agtcgtcatt ccgggaatta 1573801 tggagcacat tgaacgtgcg ggcgttcact ccggagactc aatcgctgtt tatccgcctc 1573861 agtctctcac agaggacatt aagaaaaaaa ttgaacaata cacgatcgca ttggctaaag 1573921 ggctgaatat tgtcggtttg ctcaatattc aattcgtctt gtcgcaaggc gaggtgtacg 1573981 tgctagaagt gaatccgaga tcaagcagaa ccgtaccgtt tttaagcaaa attacgggta 1574041 tcccaatggc gaatctcgca acaaaaatca ttcttggtca aaagctggct gcgtttggct 1574101 atacagaggg ccttcagcct gaacagcaag gtgtatttgt aaaagcgccg gtcttctcct 1574161 ttgccaagct gagaagagtg gatattacgt tagggcctga aatgaaatca acaggtgaag 1574221 tcatggggaa agattcgaca cttgaaaagg cgctctacaa agccttgatc gcttcaggta 1574281 ttcaaatccc gaactacggt tccgtgcttt taacagtagc tgataaggac aaagaagaag 1574341 ggcttgccat tgctaagcgg ttccacgcga tcggctacaa cattttagcg acggaaggaa 1574401 cggcaggcta cctgaaagaa gcttccattc cagcgaaggt cgtcggaaaa atcggtcagg 1574461 atggcccgaa cttgcttgat gtcatcagaa acggagaagc gcagtttgtc atcaatacgc 1574521 tgacaaaagg aaagcagccg gcaagagacg gttttagaat cagacgtgaa tcagtagaaa 1574581 atggtgttgc ctgcctaaca tctttagata cggcagaggc gatattgcga gtgctggaaa 1574641 gcatgacatt ccgtgctgat caaatgccgg cagtcaacac aaatcaggag gcggcagtca 1574701 ctatatgaaa aaagcgtatt tgacagtatg ttctaaccag caaattgcag accgggtgtt 1574761 tcaaatggtt ctgaaagggg agcttgtcca agggtttaca acccctggac agttccttca 1574821 tcttaaagtg agcgaagcgg ttacgcctct tttgagaagg ccgatcagca tcgcagacgt 1574881 caactttgaa aaaaatgaag tcaccatcat ttatcgggta gatggggaag ggacaagact 1574941 cttgtcactg aagcagcagg gagaacttgt ggatgtcctc gggcctttgg gaaatggctt 1575001 tcctgttaat gaagttcaac ccggaaagac ggctttgctg gtaggaggcg gagtaggtgt 1575061 gccgcctctc caagagctgt cgaaacgctt gattgaaaaa ggggtaaatg tcatccacgt 1575121 tttaggattc caatcggcaa aggatgtttt ttacgaggaa gaatgccggc agtacggaga 1575181 cacgtatgtg gcaacagctg acggaagcta cggggaaacc ggatttgtca cagatgtgat 1575241 taaacggaaa aagctagagt ttgatatcct cctcagctgc gggccgacac cgatgctcaa 1575301 ggcgttaaaa caggaatatg cccataaaga agtatatctg tccatggagg aacgaatggg 1575361 ctgcggaatc ggcgcatgct tcgcgtgtgt gtgccataca aacgaaagtg agacatccta 1575421 tgtaaaagta tgtctcgacg ggcctgtatt taaagctcag gaggtggcgc tgtaatgcta 1575481 gaggtgaaat tgccgggact tgatttgaaa aacccaatca ttcctgcatc aggctgcttc 1575541 ggttttggaa aagaattttc acgtttttat gatttgtctt gtcttggagc tatcatgatt 1575601 aaggctacga caaaggagcc gcgctttggg aatccgacgc cgcgggtagc tgagactggt 1575661 gctggaatgc tcaatgcgat cggtctccaa aatccggggc tggatagtgt gttgcatcat 1575721 gagctgccgt ggcttgagca gtttgataca ccgatcattg ccaatgtcgc aggttctcaa 1575781 gtcgatgatt atgttgaagt cgcagaacat atcagcaaag cgcctaatgt tcatgctctt 1575841 gaattgaata tttcctgccc gaatgtgaaa acaggcggaa tcgcttttgg cacgaatcct 1575901 gaaatggctg ccgatttgac aaaagcggtg aaagaggttt cggatgtacc cgtttatgtg 1575961 aagctatccc cgaacgtggc taatatcaca gaaattgcat tagcgatcga ggaagcggga 1576021 gcggacggtc ttacgatgat caacacacta atcggcatga gactcgattt aaaaaccggc 1576081 aaaccgatat tagcgaataa aacaggggga ctttcgggcc ctgctgtgaa gccggttgcc 1576141 attcgcatgg tgtatgaagt cagccagatg gtcaacatcc cgattatcgg aatgggaggc 1576201 gtgcaaacgg ctgaagatgc cctggaattt cttctcgcgg gagcaagcgc agtcgctgtc 1576261 ggaacagcaa actttgtgaa tccttttgca tgtccagaga ttattgaaca gctcccatct 1576321 gttttgctcc aatacggcta tcaatcaatt gaagaatgca tcggaaggag ctggaatcat 1576381 gaaaaacaac ctgcccatca tcgcgcttga ttttgcgtca gctgaagaaa cacttgcgtt 1576441 cttagcgcct tttcagcaag aaccgttatt tgtaaaggtt gggatggagc ttttttatca 1576501 agaagggcca tctatcgtga aacaactaaa agaaagaaac tgcgagctat ttttagatct 1576561 aaagcttcat gacatcccga ctactgtaaa caaagcgatg aagcgccttg ccagtcttgg 1576621 agtagacctc gtcaatgttc atgctgccgg gggcaaaaaa atgatgcagg cagctctcga 1576681 aggcttagaa gaaggtacgc cggctggaaa aaaacgtccg tcacttatcg cggtaaccca 1576741 gctgacaagc acatctgaac aaatcatgaa agatgaactg ctgatcgaaa agtctctgat 1576801 tgatacggtt gtgcactaca gcaaacaggc ggaagaaagc ggactggatg gagtggtctg 1576861 ctctgttcat gaagcaaaag ccatttacca agcggtgtcg ccttcatttc tgactgtcac 1576921 tccggggatc agaatgtcag aggacgctgc gaatgaccaa gttcgcgtag cgacgcctgc 1576981 cattgcaaga gagaaaggtt catcagcgat tgtagtagga cgctcgatta caaaagcgga 1577041 agacccggta aaagcctata aggctgtcag acttgaatgg gagggaatca aatcttgaaa 1577101 caaatcatcg caaaacatct attagacatc caagctgtat ttttacgccc gaacgagccg 1577161 ttcacatggg caagcggcat tttatcaccg atctactgtg acaaccgcct tacgctatct 1577221 ttcccagagg tcagaaacga tgttgcttca ggtatcagca agcttgttaa agagcatttt 1577281 cctgaagctg aaatgattgc gggaacagca actgccggta ttcctcatgc tgctcttgcg 1577341 gcggaccatt tgaatcttcc gatgtgttat gtgaggagca agccgaaggc gcacggaaaa 1577401 ggcaatcaga ttgagggagc tgtgcaagaa gggcaaaaaa cagtcgtcat tgaagactta 1577461 atttccacag gaggcagcgt gcttgaagct tgtgcagctt tacaagcggc cggctgtgaa 1577521 gtgcttggtg tcgtctcaat ctttacgtac ggacttccta aagcggagga agccttcgca 1577581 aaggcagaac tgccatacta ctcattaacc gattatgata cgctcacaga ggtcgcgctt 1577641 gaaaacggaa atattcattc agatgatcta aaaaagctgc aaacatggaa acgaaatccc 1577701 gagtcaaaag attggtttaa aaaataaaaa ataaattcaa atgatgtaaa gaggcttcaa 1577761 agccttgctg tacttgaaaa caggctgtga ggcctgtttt tttattaatc ctataaaaaa 1577821 agtcgggttg acttatgtta gaattgtgct aaaatttact acaaatctaa aaacttatca 1577881 agagcggctg agggactgga cctatgaagc ccggcaacct gcatagtttg taaggtgcta 1577941 cttccagcaa aatgaattcc attttgaaag ataagggctg catgctgttc ctgtctttct 1578001 ttccgccgga ttgaaagttt tttattttaa gaggtaaaaa ggctatctgt atatcagcag 1578061 ccgcgaatca cattacatgg gaaaagacaa ccggcagaaa gctactgttt gtttgtctcc 1578121 gaaaggagga aagaagaaat gttaacgtat gataattggg aagaaccaac gattacattt 1578181 ccggaagacg atccttataa aggagcgctg tcagttttaa aatgggcata cggccattac 1578241 ggcgatcagc ttgtttatgc ctgcagtttc ggaattgagg gaatcgttct gattgactta 1578301 atttataaag tgaaaaaaga cgcagagatt gtgtttcttg atacaggact tcattttaaa 1578361 gaaacctatg aaacaattga acgagtgaaa gagcgttatc cgggtcttaa tatcatcctg 1578421 aaaaaaccag atctcaccct tgaggaacaa gccgaagaac atggtgacaa actatgggaa 1578481 agagagccga atcagtgctg ctatcttaga aaggtcgttc ctttaagaga ggcgctttca 1578541 ggacatccag cctggctttc cggcctgcgc cgtgatcaag ggccaagccg tgccaatacg 1578601 aatttcttaa acaaagatga aaaattcaag tcagtaaaag tttgcccgct tatccattgg 1578661 acttggaaag acatttggag atatacatcc cggaatgaac tggactacaa tccgcttcat 1578721 gaccaaggct atccaagtat tggctgtgcg ccttgcactt ctcccgcttt tacagcagaa 1578781 gatttgcgct caggcagatg gaatggtatg gcgaaaacag aatgcggact gcatgaataa 1578841 ggagctgcaa aatggaatta gccgctattt tatttagctt gtttttcgcg atgaatattg 1578901 gtgcaagcgg cgctgcagct tcgatggggg ttgcttacgg ctccggagcc atcaaaaaga 1578961 aaacttacgc tttgatccta tgcgcagtcg gtgtctttgc cggggcggtc attggcggag 1579021 gcgaggttgt aaaaacaatc agctccggca ttattcctga gcagacgatt acactgacga 1579081 ttgtttgcat cattattgga gctgctgccc tgtcgctctt tactgctaat ctgctcggca 1579141 ttcctttgtc gacaagtgaa gtaacagtcg gcgcggttgt cggcgtggga gtggcttata 1579201 aagtattgtt tgtgaacaat cttctgatca ttgtgtcatt ttgggttttt gtcccgctgt 1579261 tcgctttcgg cttcacctat ttcgtatcta agctgtttcg ttattttaag attgaagtaa 1579321 aatcttctaa aaagcaaaaa atcctcggca ttgttttgtt agttgccgga tttttcgaag 1579381 cattctctgc cggcatgaat aacgtggcga atgctgttgg cccgttagta gctgccggtg 1579441 tgcttgatgt cggaaaagga accttgtatg gaggagcttt tgttgctctt ggcgcactgt 1579501 tattaggccg gcgagtgcta gaaacaaacg ggaagaaaat tacgaggttc tccaaagggg 1579561 aaggcattct cttatccggt acaggagcgg gactggtgat catcagttct gtatttggga 1579621 tgccggtgcc cttggcgcaa gtcacgtcat cgtctattat cggaataggc atggcgaaaa 1579681 acggtccgaa cgtgttccat aaacaagttg ttcaaacgat gctgaaggta tggatcgtat 1579741 cgccgttttt atctttatcg atttcttatc tgcttgtatc cttgttttta aaagcagatt 1579801 attattcgat ctttatcatg gtaagtgtgc ttttagcggc gggcggtgcc atcagcctga 1579861 caaaggccat tcgtaaagag agacgctcag tccacgaaca aggcggggga atctgatcat 1579921 taatctgagt aattttataa gttaactagg aggagatgga tattatgagc ttagcaccac 1579981 acggaggaac attagtaaac agagtagatg aatcatatga tgtgagcggc attcaaaaag 1580041 aaattgaact tgatttaatt tctttcgcgg atttggaatt gatcggtatc ggtgcataca 1580101 gcccgattga aggtttcttt aatgaaaaag attacgtatc agtggtcgaa aacatgcgtc 1580161 tttcttccgg cgttgtctgg tctcttccaa tcacgcttcc ggtcgatgcg caaaaagcag 1580221 cggaactgtc acttggtgaa acggtaaagt taacgtatga aggagaaact tacggcgtta 1580281 tccaaatcga agacctgtac gtgcctgaca aacaaaaaga agctgtcaat gtgtacaaaa 1580341 cagatgaaca ggagcatcct ggtgttaaaa agctgttcag ccgcggcaat acatatgtcg 1580401 gcggaccgat tacgttgatt aaaaaagctt caaaacagtt ccctgaattt acatttgaac 1580461 cgtcagaaac gagacgccag tttgcggaaa aaggctggga aaccattgtc ggtttccaaa 1580521 caagaaaccc tgttcacaga gcgcatgaat acattcaaaa aacggctctt gaaacagtag 1580581 acggcttgtt cttgaatccg ttagtaggtg aaacaaaatc tgatgacatt ccagctgatg 1580641 tacggatgga aagctaccaa gtgcttcttg atcattatta cccgaaagat cgtgttttcc 1580701 ttggtgtctt tttagcggcg atgcgttatg caggcccgag agaagcaatt ttccacgcgc 1580761 ttgtcagaaa gaactacggc tgcacacatt tcatcgtcgg ccgtgatcat gcaggtgtag 1580821 gcgactatta cggaacatac gaagcacagg aactgtttga cacatttaaa cctgaagaac 1580881 tcggaattac accgctgaaa tttgagcaca gcttcttctg taaaaaatgc ggaaatatgg 1580941 gaacagcaaa aacttgccct catggcagag agcatcacgt cattttatca ggcactaagg 1581001 taagaggtat gctgagagac ggtgtgctgc cgcctgctga attcagtcga aaagaagtag 1581061 tagaagtgtt aatcaaaggg atgaagaaaa aagaagaagt aggcgtatct taaggaggac 1581121 tggcagtgac aaatcgcgat attgtatggc atgaagcctc tatcacaaaa gaagagtatc 1581181 agcaaaaaaa caagcataaa agctccattc tctggctgac agggttaagc ggctcaggca 1581241 aatcaaccat tgccaacgcc gctgcgagag aattgtttga gcaaggctac caagtcattg 1581301 tgctggacgg ggataatatc cgtcacggcc taaataggga tcttggtttt tctgatgaag 1581361 accgaaaaga aaacatccgc cggatcggag aggtggcgaa gctttttgtt cagcagggaa 1581421 ccattgtgat tactgctttt atctctcctt tccgcgagga cagacaacag gttcgcgagc 1581481 ttgtggaagc gggcgaattt aatgaagtct acattaaatg cgaccttgat atttgtgaac 1581541 aaagagatcc gaaagggctt tacaaaaaag caagaaacgg cgagattccg ttctttacag 1581601 gaattgattc tccttatgaa gaaccggaag ctccagagct cgttcttgat tcaggacagc 1581661 atgaccgtga agcgtgtaaa aatcagctga tcgagtttgt taaacaaaaa ttgagctgaa 1581721 tatgatctgc tgcgttcttc tcagatgccg gaatgcaagc gagaacatca tcacagcgaa 1581781 tcttctggaa gaactcgaat agatcggggg aaatacgatg gggaaagtat atattgtagg 1581841 agcgggtccc ggtgaccctg atctgctgac aattaaagcg ctgaaagcca ttgaaaaagc 1581901 tgatgtcatc ttatatgaca gattagtaaa taaagagatt ttacaatatg ccaaagagca 1581961 agcagacctg atctactgcg ggaagcttcc ggattttcat acgatgaagc aggaaaccat 1582021 caatcgattt cttgtgaagt atgcgcaaaa agggaaaatg gttgtcagac tgaaaggcgg 1582081 agaccctttt gtgttcggga gaggagggga agaagcggaa tgcctctctg aaaatggaat 1582141 tccgtttgaa atcattcccg gcattacgtc tggaatcgcg gcagccgctt atgccgggat 1582201 tcctgttacc catcgggatg cgggctctaa cgtcgctttt gtaacgggtc actataaaaa 1582261 agaagaagat tttgaggaaa agtggaaagc gctggctaca ggaattgata cacttgtcat 1582321 ctatatgggt atcaaaaacg tgcagcagat tgaaagaaaa ctccttgaaa atggccggga 1582381 cggttctacg ccagcagcct ttattcattg ggggacaacg gacaagcaaa aatctgtttt 1582441 ttgtacagtt gacacccttt cagaaacggt gataaaagaa aacattacaa atccgagttt 1582501 aattgtcatt ggaaatgttg taaattatca ctataagctg gaatggtttg aatctgaact 1582561 aaaaaaacaa gatttaagcg aggcgttgta aaaatgaaac aagcaatttt atatgtcggc 1582621 cacggcagcc gggtcaaaaa agcgcagcaa gaagccgcag cctttttgga aggatgcaag 1582681 gcccacatct ctgtgccagt acaagaaatc agctttttag agcttcagga gccgacaatt 1582741 gagacaggat ttgaagcatg tgtgaagcaa ggtgccactc atatcgcagt ggtgcctctg 1582801 cttcttttaa cagctgcgca tgcaaaacat gatattccgg aagaaattgt ccgtgttgca 1582861 tctcgatatc catcagtccg tatttcatac ggaaagccga tcgggattga cgaagaagta 1582921 gtcaaggctg tatatcaccg aatgaaagac ataggtgttc cgtatgaaaa tgccagagtg 1582981 gtgctcatcg gaaggggaag ttcagatcca gacgtcaaaa gagacgtaac cggaattgct 1583041 aatcttcttc aggaaatggt tccagtgaag gaagtcattc cgtgcttttt gacagcatgc 1583101 ggccctaatt acaaagaggt tttttcagaa cttgaaaaag atgacggcat aacaaccttt 1583161 atcgttccat atttgctttt tacgggtatg ctgatgaatg aaatcgaacg agaggttcag 1583221 aaattaaaag cccataatcc gaacgtctac ctctcttcct atatcggttt tcatcctcat 1583281 gtgaaaaacg catttttgaa ccgtgtgaga gaaactgcgg caaattctga gggacaattt 1583341 gattttgatg gaggttcata tgcttccgct gcacattagc ctggaaaaga agaaggttgt 1583401 gattgcgggg ggcggaagca tcgctctcag aaggctgaaa acggtgattt ctgagggagc 1583461 tgatataacg cttgtcagtc cggatgtgga accggaaatc aagcaaatgg cagaagagcg 1583521 gcgtatcaaa tgggaaaaac ggacaattga aaaagaagat tatctcaatg ctttcttcat 1583581 tattgctgcg acggataatg cggcagtgaa caaagaaatt gcccaatccg cttcgccttt 1583641 tcagcttgtc aattgtgtca gtgacgctga gcttggcaat gtatatatgc cgaaaatcgt 1583701 aaaaagaggg catgtcactg tgtctgtttc tacaagcgga gccagtccaa agcacacgaa 1583761 agagcttgct gaaaacgtgg ataagctgat tgacggcgat tttgttgctg aagtgaacag 1583821 gctttatcag atgagaagaa agaaataagc cagagcatac aaatgctctg gcttttcttt 1583881 atgcggctca gctttttttg agcttgatga cagtatcagc atcaggcgtg acaaagacgg 1583941 tatgctggct gtcataagtg acgaaaccgg gtttcgcgcc gtttggtttt ttgacatgcc 1584001 tgatttttgt ataatctaca ggcactgaac ttgaatcttt agcttttgaa aaataagctg 1584061 caattgtcgc ggcttccatg attgtttgct catcaggttc gctgcttctg atcacaacgt 1584121 gggagccggg aatgtccttc gtgtgaagcc agatatcgtc tctggccgcc actcttgtcg 1584181 ttaaatattc attttgacga ttgttcttac ccactaaaat tgtcagccct gaggtggatt 1584241 catatgtttc taacaccgga ttgtgcggtt tttgcttttt ctggcctttt tgctgcttag 1584301 ggcgtaaata tttgccctca acaagctctt ccctgatttc gctgatatcc cggggagaag 1584361 cggacgaaag ctgctgaatc agctgatcaa aatattcgat ctcttcctgt gccagcctga 1584421 tttgctcctc gacaactgcg accgaatttt tcgctttctg atacttcgtg aaataggcct 1584481 gtgcgttttc agaaggcgtt ttgttcgggt ttaaaggaat cgtgattgtc gggctttctt 1584541 catcataata attgatgacc tcagcctgtt tatcaccttt tttcagcata tataaattag 1584601 cggttaaaag ctctccgtaa agctgaaatt ccttcgcgtt ttccgaatac tccagggttt 1584661 tctctaattt tttgattttg ttggcattct tcttccgttc gttcacaaca aaacgctcaa 1584721 gatcctgagc ctgttgctta acccggtctc gttcagcttt tccgaaataa aaacggtcga 1584781 gcagttcgct taatgaatca aaacggcgcg cttcgccctt tagatgagtc agctccagca 1584841 gataaaaata ttcctttccg tttacagtcg taatgttggg aatgaaacgg tgctctttca 1584901 cttcggcaaa cagtgccagc aacgcttttg gcagtgtgac tttgttggca aggcctgctc 1584961 tgtgaaccgc ttctttggcg aaaagcggag acacgcctga aaagtggtcg acaatttgtt 1585021 tatcaagcct tccttcttga aagctgaggt gacgcaaaat atcatcttct gacgcctcaa 1585081 gaggcgatat tttgtcctga gcaggcggaa gcttataatc ttggccgggc agtactgtac 1585141 ggtagctgtt cattgacggt gataaatgct taagtccgtc gataatcaca ttttctgctg 1585201 cgtcagtcaa aatgatattg ctgtggcggc ccataatttc tacataaagc tttcgtacgg 1585261 tttcatcgcc aatttcgttt cggcttttga tatgaaaaat cataatgcgg tctaagcccg 1585321 cttgttcaat tttctcaatg aatccgcctt cgatatgctt tctcagcaac atgcaaaaca 1585381 ttggcggttc gcttggattt tcataagctt gtgccgtgat atgcacccgt gaatagctcg 1585441 gatgtgccga taataatagt ttttggtttt ttcccttggc acggatgtgg aaaatcacat 1585501 cgtgcttata tggctgatgg atttttgtaa ttcgtccgcc cattattttc tcgttaagtt 1585561 cgtgtgtcat tccgtatgta aacatgccat caaacgacat atgcaataca ccctctcatt 1585621 cttcctgcat tcgataatta tagcatgaaa tgggacgagt cagaataagc atgcttatag 1585681 agtgatatct ctataagaga gcaggggagt ggacgagcgg aatgaagttt catgaaatgg 1585741 gacaaacaga tttactagag gcaaccaata cgtccatgaa acaaggatta acagaaaaag 1585801 aggtaaaaaa acgccttgac aagcatggac caaacgagct gcaagaaggg aaaaaaactt 1585861 cagcgcttct cttgtttttc gcgcagttca aagattttat ggtgcttgtg cttctggcgg 1585921 caacgttaat ctcaggattt cttggtgaat atgtagatgc ggttgcgatt attgcgattg 1585981 tgtttgtgaa tggcatactc ggtttctttc aagaaaggcg tgctgagcaa tctcttcagg 1586041 ctttaaaaga gctttcaaca ccgcacgtca tggcactcag ggaaggaagc tggacaaaga 1586101 ttccttctaa ggaactggtg ccgggtgata ttgtgaaatt tacgagcggg gacagaattg 1586161 gcgcagacgt tcgaattgtt gaagcgagaa gccttgaaat agaagaatca gcgctaaccg 1586221 gggaatcaat cccggttgtg aagcatgctg ataaattgaa aaaaccggat gtttcactcg 1586281 gcgatattac caatatggca tttatgggta cgattgtgac ccgcggcagc ggtgtcgggg 1586341 ttgtcgtcgg gacaggaatg aatacggcta tggggaaaat tgccgacatg cttgaatcgg 1586401 cagggacatt gtcaaccccg ctgcaaagaa gactggagca gctcgggaag attttgattg 1586461 ttgttgcatt gcttctgacc gtacttgtcg ttgctgtcgg tgttattcag ggtcatgatc 1586521 tgtacagtat gtttttagca ggtgtctcgt tagcggtagc cgctattccg gaggggctgc 1586581 cggcgattgt gacagtggcg ctttcgcttg gtgtacagag gatgattaaa caaaaatcca 1586641 ttgttagaaa gcttcctgct gttgaaacgc ttgggtgtgc gtctatcatt tgctcagata 1586701 aaacagggac aatgacccaa aacaaaatga cagtgacgca tgtctggtcc ggagggaaaa 1586761 catggagagt ggcaggggcc ggctatgaac cgaaaggaag cttcacacta aacgaaaaag 1586821 agatcagtgt caatgaacat aagccgcttc agcagatgct tctgttcgga gcgctttgta 1586881 acaactccaa tattgagaaa agagacggcg aatatgtgct tgacggagat ccgacagagg 1586941 gagcgctgct caccgcggca agaaaaggcg gtttttcaaa ggagtttgtt gaatctaatt 1587001 acagagtgat tgaagaattt ccgtttgatt ccgcacggaa aatgatgact gtcatcgtag 1587061 agaatcaaga cagaaagcgc tatatcatta caaaaggtgc gccggatgta ctcatgcagc 1587121 gatcttcccg tatttattat gatggctcag cggctctttt ttcaaatgaa agaaaagcag 1587181 aaacagaggc ggtattaaga catttggcat cacaggcgct cagaacgata gcggtcgcct 1587241 acaggccgat aaaagcaggc gaaacaccgt caatggagca ggcggaaaaa gatctgacca 1587301 tgcttggcct ttcaggtatc attgatcccc cgcggccgga agtcagacag gcgattaaag 1587361 aatgccgtga agcgggaatt aagaccgtca tgattacagg tgatcatgta gaaaccgcta 1587421 aagcgatagc gaaagacttg cgcctccttc cgaaaagcgg caaaatcatg gacggcaaga 1587481 tgctgaatga actttctcaa gaagagcttt ctcatgtggt ggaggatgtg tatgtatttg 1587541 cccgcgtttc ccctgaacat aaactaaaaa tcgtaaaagc ctatcaggag aacgggcata 1587601 ttgtggcgat gacgggagac ggcgtcaatg atgctcctgc cattaaacag gctgatatcg 1587661 gcgtctctat gggcattacc gggacagatg tggccaaaga agcatcatct cttgttctcg 1587721 tggatgataa ttttgcgacg attaaatcag cgataaaaga aggcaggaac atctacgaaa 1587781 atatcaggaa gtttatcaga tacctgttgg cgtctaacgt cggagaaatc cttgtcatgc 1587841 tgtttgcgat gctgcttgcc cttcctttac cgctggttcc gattcagatt ttgtgggtca 1587901 acttggtgac ggacggattg ccggcaatgg cgctcggcat ggatcagccg gaaggagacg 1587961 tcatgaagcg caagccccgt catccgaaag aaggggtatt tgcccgcaag ctaggatgga 1588021 aggtcgtttc cagaggattt ttaatcggag ttgccactat tttagcgttt atcattgtgt 1588081 accaccgcaa tccggaaaac ttggcttatg cccagacgat cgcgtttgcc acattggtgc 1588141 tcgctcagct tattcacgtg tttgactgcc gcagcgaaac ttctgttttc tctagaaatc 1588201 cgtttcaaaa cctgtattta atcggcgcgg tattgtcatc cattttgctg atgcttgtag 1588261 taatctacta tccgccgctt cagccgattt tccatactgt agccatcacg ccgggggact 1588321 ggatgctcgt catcggtatg tccgccatcc ctactttttt gctggcgggg tcacttttaa 1588381 caagaaaaaa ataaattcat atgatataat cttaggggta atagcgtgtc tattgccctt 1588441 ttattatgag aacagggaag aattgggtgt tttaaaatga tacgaagtat gacaggcttc 1588501 ggcagtgcaa gcaaaacaca agacgatctc tctgtaagcg ttgaacttaa atctgtgaac 1588561 tacagattta aagaagtgaa cgctcgtttg ccaaggcctt tgctatattt tgaagataag 1588621 ctgaaacaga ccattctgca gcatattcag cgcggaagaa ttgagctttt cgtatccgtt 1588681 gacagcgata tgcttgttga gaaaaggctt gaaattgatt ggccgctgct cgatgagttt 1588741 gtcgcagccg cgagagatat gaagaagcgg tatcaattgt ctgcagagcc cgatgtaatg 1588801 gatttcttta agcttgatca tgtcgtccag gttcatgaag aacagacgca aaatgacaag 1588861 ctggaggcgt tgatcatcga tgctgcagaa gaagcggtaa aaggtctctg tgaaatgcgt 1588921 gaaaaagagg ggctgctctt agcgaaagac tgcctgatgc atattgatca gcttgaagag 1588981 ctggtgagag aaactgaatt gctggctgca gatgtcgtat ctcgttaccg ggaacggctg 1589041 tatgccagaa tcaaagaatg gactgaagac gtattagacg agagccggct tgtaacagaa 1589101 tgcgctattt ttgcagaccg ctctgatatc actgaagaga ttacaaggct gaagagccac 1589161 ttcgcccagt ttcgtgatat attagctagt ggcggagctg tcgggcgcaa actcgacttt 1589221 cttgttcagg agctcaatcg ggaagcaaat acgatcggct caaaagcaaa tgatcatcag 1589281 atcacaaagc ttgtcgttga aatgaaaagt tctattgaaa aaataaaaga acaagtgcaa 1589341 aatatagaat agtgactgtg cgtattgttt acagacggtc ttactaggct aaactagaga 1589401 cgtctatttt acagggggaa cgtagaagat gacgattaaa ctgattaata tcggatttgg 1589461 caatatcatc tccgccaatc ggatgatttc gattgtcagc ccggagtctg cgccaatcaa 1589521 acggatgatt caggatgcaa gagaccgcgg aatgctaatt gacgctacat acggacgaag 1589581 aacccgtgca gttgtcgtca tggatagtga tcacattatc ttatctgccg tccagcctga 1589641 gacagttgca cacagacttt ctgttaaaga agaaattatg gatgaagggc aggggtaatt 1589701 gccgcatgaa agaaagaggg ttattaatcg ttctctcagg tccctcagga gttggtaaag 1589761 gaacggttcg acaagcgatc ttttcgcagg aagacacaaa atttgaatat tcgatttcag 1589821 taaccacaag aagtccaaga gagggcgaag tgaacggagt cgattatttt ttcaaaacaa 1589881 gagacgaatt cgagcaaatg attgcggaca acaagctgct tgaatgggca gagtatgtcg 1589941 gcaattatta cggcacgcca gtcgattatg ttgaacagac gcttcaagat ggaaaagacg 1590001 tctttttaga aattgaagtt caaggggctc ttcaagtgag aaatgctttc ccggaaggcc 1590061 tgtttatttt ccttgcgcct ccaagccttt ctgaactgaa aaacagaatc gtgacacgag 1590121 gaacagaaac agacgctctg attgaaaatc gaatgaaagc cgcaaaagct gagatcgaaa 1590181 tgatggatgc ttatgactat gtcgttgaaa acgataatgt cgaaacggct tgcgataaaa 1590241 tcaaagcaat cgttcttgct gaacatttga agcgtgaacg cgttgcacca agatataaga 1590301 aaatgctgga ggttgaataa tcaatgttag atccgtcaat tgattcttta atgaataaat 1590361 tagattcaaa atatacgctg gtgactgttt ctgcgagacg tgcccgtgaa atgcaaatca 1590421 aaaaagacca aatgattgaa catacgattt cacacaaata tgtaggcaaa gctttagaag 1590481 aaattgatgc aggcctgctt tcgtttgaaa aggaagaccg cgaatagtag cacaagtagc 1590541 aacctatatc atgtaggttg ttattttttt ccgtgcggtt ttgtaaagtg cagaggggga 1590601 gaattcattg cttaacaatc gaaatgtgtt actttgcgtg agtggaggca tcgctgttta 1590661 taaagcctgt gcgttaacga gcaagctggt tcaggcagga gcaaatgtca aagtgattat 1590721 gactgaatcc gcttgccgat tcgtttcacc gctgacattt caggcattga gccgccacga 1590781 agtctataca gatacattta aagaacaaaa tccaagcgtc atttctcata ttgatgccgc 1590841 agactgggcc gacttgatta tcgtagcgcc ggctacggct aatgtgattg gaaaactggc 1590901 aaacggcatc gctgatgata tgctgacgac aacattgttg gcagcaacgg ctcccgtttg 1590961 gatcgcgccg gcaatgaacg ttcatatgta tgaccacccg gcagtcaaac gaaacatttc 1591021 tgttctttat caggacggtt attgttttat tgagccaagt gagggctatt tagcatgcgg 1591081 ttacgtagga aaaggcagat tggaagagcc ggaaaacatc gtaaagctgg ccgaaaaaca 1591141 ttttgctgaa gaaacatccg ctcctttaga aggcaagcat gtggtcatta cagccggccc 1591201 aacgcgggaa gcgattgatc ctgtccggtt ttttaccaat aaatcgacgg gcaaaatggg 1591261 ctacgcactg gcggaggctg ctgttcagct cggcgcacgg gtaatcttaa tttctgggcc 1591321 tgtttcactt gatcagccta aaggccttgc tgagtttatc cctgttcaat cggctgcgga 1591381 tatgcgcgaa gctgtgctct ctgtgtatga cgcaagcgat atagtcatta aaacagctgc 1591441 ggtagccgat tttacgccga aaacagtatt tgaccataaa atgaaaaaac aagacggcgg 1591501 catgacctta gaactgaaaa gaacagtcga tattttgaaa gaattgggcg agaaaaagaa 1591561 agagcagatt ttggtcggat ttgccgccga aacacaagac attgaacact atgcacgtaa 1591621 aaagctcgcc gctaaaaacc ttgatttgat tgtggcaaat gatgtgaaag caaatggggc 1591681 cggttttggt gctgatacga atatcgtgac aatctttttc aaagacgggc ataaacgcga 1591741 actcccgatt atgtctaagc tcgatgtttc ttttgaaatc cttcaggaga tcgcagccct 1591801 ctcaaaacaa accggagagc gctcatgaat tttgcagaag tcatcgttga tgtcagcacc 1591861 aaaaatatag acaggccttt tgattataaa atcccagacc atctgaaggg catgatcaaa 1591921 acggggatgc gggtcattgt tccgtttggc ccccgtaaga ttcaagggtt tgtgacagca 1591981 gtcaaagaag catctgacct atcgggaaaa tctgtcaagg aagtagagga tttattagat 1592041 cttacacctg ttctgacaga ggagcttatg attctgtcat catggctgtc agacaaaacg 1592101 ctgtctttta aaataacggc gcttcaagca atgctgcctg ccgccttaaa ggcgaaatat 1592161 gaaaaagaat taaaaattgc acacggagcc gatcttccgc cgcaagtgga acggctgttt 1592221 tctgaaacaa agacgctgct gtattcagat atacccgatc atgagacgct gaaactgatt 1592281 caaaggcatg ttcaaaaagg ggacattgac gtgacgtata aagtcgcgca aaaaaccaat 1592341 aaaaaaatgg tcaggcatat tcaggcaaat gcgagtaaag aagagcttgc taagcaggct 1592401 gagggattgt cccgccaagc agcaaaacag caggcgattc ttcactttct catctctgag 1592461 ccggaaggtg tgaaaattcc tgcggcggaa ttgtgcaaaa aaacggacac gagctctgca 1592521 accatcaaaa cccttatcca aaaagggctt ttgaaggaaa gctatgaaga ggtttacaga 1592581 gatccctatc aggacaaaat gttcaaaaaa acagagcccc tgccgctgac agacgaacag 1592641 agggctgcct tcgagcccat acgcgagaca ttggacagcg atgagcataa agtgttcctc 1592701 cttcacggcg tgacaggaag cggaaaaacc gaaatttatc tgcaatcaat tgaaaaagta 1592761 ctggcgaaag gaaaagaagc catcgtcctc gtaccggaaa tatcgctgac gccgcaaatg 1592821 gtcaaccgct tcaagggccg cttcggctcc caggtggcag tcatgcacag cggtttatcc 1592881 acaggagaaa aatatgacga gtggcgtaaa atccaccgga aggaagtacg gcttgtcgtc 1592941 ggtgccagat ccgccatttt tgctccgttt gaaaatctcg gaatgataat catcgatgaa 1593001 gagcacgagt cttcctataa acaggaagaa atgccgcgct atcatgcgaa agaggtggca 1593061 atcaagcggg ctgagcatca cagctgcccg gttgtattag ggagtgctac gccgacatta 1593121 gaatcatatg ctagagcgca aaagggcgta tacgagcttc tttcactgaa gcaccgtgtt 1593181 aaccatcggg tgatgcccga ggtttcgctt gtcgatatga gagaggagct tagaaacggc 1593241 aatcgctcga tgttttcagt tgaattgatg gaaaagcttg aagaaacgat tgccaagggt 1593301 gagcaggcgg tgctgttttt aaataagagg ggctactctt cctttgtgat gtgcagggat 1593361 tgcggctatg tcccgcaatg cccgcactgc gacatttcca tgacgtatca tcgttacggc 1593421 caaaggctga aatgccatta ttgcggacat gaagagcctg ttccgcacac ttgtcctgaa 1593481 tgcgcaagcg agcatatccg ctttttcgga acgggaacac agcgagtgga ggaagagctg 1593541 acaaaagtgc tgccaagtgc gagagtgatt cggatggatg ttgacacgac atcacggaaa 1593601 ggcgcccatg aaaaattact gtcagctttc ggagaaggaa aagcggatat tcttctcgga 1593661 acgcaaatga tcgcgaaagg gcttgatttt ccgaatgtca cgcttgtcgg agtgttaagt 1593721 gctgatacaa cacttcatat tcctgatttc agatcggctg aaaaaacatt tcagctgtta 1593781 acgcaagtca gcggccgggc aggcaggcat gaaaagcccg gccatgtcat cattcaaacg 1593841 tatacaccgt ctcattacag tatccagctg acgaaaacac acgattatga aacgttctat 1593901 cagcatgaaa tggcgcacag gagagagcaa tcctatccgc catactacta tttggctctt 1593961 gtgactgttt ctcatgagga agtggcgaaa gcagcggtta cagctgaaaa aatcgctcat 1594021 tttttgaaag caaactgcgg agctgacacg aaaattctcg gaccaagcgc gtcgccgata 1594081 gccaggatca aagatagata tcgctatcaa tgcgtgataa aatacaaaca ggaaacccag 1594141 ttatccgctt tattgaagaa gatactggaa cattataaac gcgaaattga acaaaaacat 1594201 gtaatgattt caattgatat gaatccttat atgatgatgt aagatctcac gtcttggagg 1594261 gtaacaaatt ggcagtaaaa aaggtcgtca cacatcctgc ggaggttttg gaaacacctg 1594321 cggaaaccgt gactgttttt gataaaaagc taaaaaaact gcttgatgat atgtacgaca 1594381 ccatgcttga aatggatggt gtcggactgg cagcgccgca aatcggcatt ttaaaaagag 1594441 cggccgtcgt agaaatcggg gatgacagag ggagaattga tctcgttaat cctgaaattt 1594501 tagaaaaaag cggcgagcaa accggaattg aaggatgctt gagctttcct aacgtctatg 1594561 gtgatgtcac acgtgccgat tatgtcaaag tgcgtgcgtt taaccgtcag ggaaaaccgt 1594621 tcattctgga agcgcgaggc tttttagcaa gagccgtgca gcatgaaatg gaccacttag 1594681 acggtgtgct gtttacatct aaaataagta aatactatac agaagatgaa ctagcggata 1594741 tggaaggatg atttgatgac gagaatcgta tttatgggaa cgccggattt ttcagttcct 1594801 gttttaagaa ccctgataga ggacggatat gaagtagtgg gggtcgtcac acagccggac 1594861 cgtccgaagg gcagaaaaaa agtactgaca cctcctccgg taaaggaaga ggcattgcgc 1594921 cacggcatcc cggttcttca gccggaaaaa gtcagattga cagaagaaat tgaaaaagtg 1594981 ctggcattaa agcctgacct gattgtaacg gcggcattcg gacaaatttt gcctaaagag 1595041 cttctcgaca gtccaaaata cggctgcatt aacgttcacg catccctttt gccggaactg 1595101 cgcggcggtg ctccgatcca ttattccatt ctgcagggaa agaagaaaac cgggattacc 1595161 attatgtata tggtagaaaa attggatgcg ggcgatatga tctcaaaagt ggaagtggac 1595221 attgaagaaa ccgacaatgt cggaacactg cacgataaat taagcgttgc tggcgcgaag 1595281 ctattgtctg aaacggttcc aaacgttatt gccggcagca tatcacctga aaagcaggat 1595341 gaagagaaag cgacgtacgc gcctaacatt aaaagagagc aagagctgct cgactggtcc 1595401 agaacgggcg aagagcttta caaccagatc cgcggcttaa atccatggcc tgttgcttat 1595461 acgactctaa acggacaaaa cttgaaaata tgggcgtcga aaaaaatagc ggcaccaaca 1595521 acagctgagc ccggcacagt cgttgcagtt gaaaaggaag gaattatcgt tgccacaggt 1595581 aacgagacgg ctctgttatt aaccgaactc cagccggcag gcaaaaaacg aatgaaaggc 1595641 gaagactttg tgcgaggcgc tcatgttgaa gccggtgatg tgttaggagt aaacaatgaa 1595701 aaaaactagt gttcgtgaca tcgcccttga ggcgctgatc aaattagaac aaaaccaggc 1595761 atacagcaac ctgctgctga aatcggtcat taaatcaaat gaactgagtg atcagaacag 1595821 agggcttttg actgaacttg tctatggtac attacaaaat aagatcgcgc ttgattatat 1595881 gcttaaaccg tttatcaata agcctcaaaa ggtaaagccg tgggtgattc agcttcttcg 1595941 cctatcctta tatcaaatgg agtatttgga gaagattcca gacagggcag ccattcatga 1596001 agcggttgag attgctaaaa tccgcggaca caaaggcatt gcttcatttg tcaacggcgt 1596061 gctccgttct attcagcgcg aaggtgttcc atcctttgac gcgatcgaag atcctgtccg 1596121 ccggctggcg acagaaacaa gccatccgga atggcttgtg aaagagtggg cggatgcgta 1596181 tggatttgaa gctgcggaaa agatttgccg catccatctc attccgccga aacagacgct 1596241 gcgtgtcaat caaatgaaag cagacagagc tgagctgctt gaccaaatgg ctgctgaggg 1596301 aatcgaagtt gaaaaaggcg acctcgctga agatgctgtg aagctcttaa agggaacaat 1596361 tgccggaact catttcttcc aaaacggcga agtttctatc caggatgaga gctccatgct 1596421 cgtcgcccgc gcccttgatc ctaagtcaga tgaaacagtg cttgacgcgt gtgcggcgcc 1596481 tggcggaaag tcggctcata tcgcagaatt aatgaagaac aaggggagcg ttacgtcgct 1596541 tgatcttcac aaacataaag tgaagctgat caaagaagcg gcagatcggc ttggcctgac 1596601 aatcattcat gcggaaacaa tggatgctag aaaagcgggg gaaacgtttg aaaacgaaca 1596661 gtttgaccga atattggtcg atgccccgtg ctcaggtttc ggtgttatca gaagaaagcc 1596721 ggacatgaaa tacacgaaaa aacctgacga cagcgcccgt ctagctgaaa tccagctgtc 1596781 gatcttgagg gaaatcgcac cattagtaaa aaaaggtggc actcttgtct acagtacgtg 1596841 tacaatggac cggacagaaa atgatgaagt aatacatgcg tttatacaag aacatcctga 1596901 ttttgaaccc gatttgtctc ttgaaaagcg gctgcctgaa aaggtgagac cctttgttcg 1596961 ggatggaagg cttcaaatcc ttcctcatta tttcggaaca gatggtttct ttatttgcag 1597021 catgagaaag aagggataag caatggcaga acttaataaa acaaaagtaa gaaaagaatt 1597081 gcggacagag cgtccgtcta tttattcttt tgaattagat gaaatcaaac aatggctgac 1597141 agacaatgga gagaaaccgt tccgtgcagc ccagatcttt gaatggctat atgaaaaacg 1597201 cgtatcttct tttgaagata tgacaaacct ctcaaaggat ctgcgtgaga aattaaacac 1597261 tcgctttgtg ttaacaacgc tgaaaacggc tgttaaacaa acctctcaag acggtacgat 1597321 gaagtttttg tttgagcttc atgacggtta taccatcgaa accgttttaa tgagacacga 1597381 gtatggcaat tctgtatgtg taacgacaca agtcggctgc cgtattggct gcacattctg 1597441 cgcgtcaacg cttggaggct taaaacgaaa ccttgaagca ggggaaattg tcgctcaagt 1597501 agtcaaagtg caaaaagctc ttgatgaaac ggatgaacgc gtcagctctg tcgtgatcat 1597561 gggaatcggc gaaccttttg ataactttaa cgaaatgctc gctttcttga aaatcattaa 1597621 ccatgacaag ggcctgaata tcggtgctcg ccatattacg gtctctacga gtggaatcat 1597681 cccgaaaatt tacgaatttg ctgatcagca aatgcagatt aactttgcaa tttctctgca 1597741 cgcgccgaac acagaaatca gaagccgttt gatgccgatt aacagagcat ataaactgcc 1597801 tgatctaatg gaagccgtta aatattatat taataaaaca ggacgccgta tcagctttga 1597861 atacgggctg ttcggaggcg taaacgacca ggtggaacac gccgaagagc ttgccgactt 1597921 gctggaagga gtcaaatgcc acgtgaactt gattccggta aactacgtgc ctgaacggga 1597981 ctatgtgcgc acaccgcgtg atcagatttt tgcttttgaa aaaacgctga aatcccgcgg 1598041 agtaaatgtc acaatccgaa gagagcaagg acatgacatt gacgcagcct gcggtcagct 1598101 tcgcgcgaag gagcgtcaag acgagacgag gtgatgaggg ttgttaacag ccttaaaaac 1598161 agatacagga aaaatccgcc agcataatga agatgatgcg gggatattca aggggaaaga 1598221 tgaatttata ttagcggttg tcgctgatgg catgggcggc catcttgctg gagatgttgc 1598281 gagcaagatg gctgtgaaag ccatggggga gaaatggaat gaagcagaga cgattccaac 1598341 tgcgccctcg gaatgtgaaa aatggctcat tgaacagatt ctatcggtaa acagcaaaat 1598401 atacgatcac gctcaagccc acgaagaatg ccaaggcatg gggacgacga ttgtatgtgc 1598461 actttttacg gggaaaacgg tttctgttgc ccatatcgga gacagcagat gctatttgct 1598521 tcaggacgat gatttcgttc aagtgacaga agaccattcg cttgtaaatg aactggttcg 1598581 cactggagag atttccagag aagacgctga acatcatccg cgaaaaaatg tgttgacgaa 1598641 ggcgcttgga acagaccagt tagtcagtat tgacacccgt tcctttgata tagaacccgg 1598701 agacaaactg cttctatgtt ctgacggact gacaaataaa gtggaaggca ctgagttaaa 1598761 agacatcctg caaagcgatt cagctcctca ggaaaaagta aacctgcttg tggacaaagc 1598821 caatcagaat ggcggagaag acaacattac agcagttttg cttgagcttg ctttacaagt 1598881 tgaagagggt gaagatcagt gctaatcggc aagcggatca gcgggcgtta ccaaattctc 1598941 cgcgtcatag gcggcggggg aatggccaac gtgtatttag ctgaggatat cattctagac 1599001 cgtgaagtcg caattaaaat cctgcggttt gactatgcaa atgacaatga atttatcaga 1599061 cgtttccgca gagaagccca atccgcatca agcctcgatc acccgaatat tgtcagcatt 1599121 tatgatttgg gcgaggaaga tgatatttat tatattgtca tggaatacgt tgaaggcatg 1599181 acgcttaaag aatacataac agcaaatggg ccgcttcacc ctaaagaagc gctgaacatc 1599241 atggagcaaa ttgtctcagc catcgctcat gcccatcaaa accagattgt tcacagagac 1599301 atcaagccgc ataacatttt gattgatcat atgggaaata tcaaagtaac ggattttgga 1599361 attgcgacgg cactaagttc gaccacaatc acccatacca attcagttct gggctcggtc 1599421 cattacttat cacctgaaca ggcccggggc ggcttagcca caaaaaaatc ggatatttat 1599481 gcgcttggaa tcgttctatt tgagctttta accggccgta ttccgtttga tggagagtca 1599541 gcagtcagca tcgccttgaa gcatcttcaa gcggaaactc cttcggcaaa aaggtggaat 1599601 ccatcggtcc cccaaagcgt tgaaaacatc atactcaagg caactgccaa agatcctttt 1599661 catcgctacg aaacggctga agacatggaa gcagacataa aaacagcttt tgatgccgac 1599721 agactcaatg aaaagagatt tacgattcaa gaagatgaag aaatgacaaa agcgatacct 1599781 atcattaaag atgaagaact tgctaaagct gctggcgaaa aagaagctga agtgacaacc 1599841 gcacaagaaa acaaaacaaa gaagaacggc aaaagaaaaa agtggccgtg ggttttgctc 1599901 acgatatgcc tcgtttttat cacagctgga attcttgctg tcactgtttt tccgtcgctt 1599961 ttcatgccta aggatgtcaa aatacctgat gtctccggaa tggaatacga aaaagccgca 1600021 gggctcttgg aaaaagaagg tttacaggtt gattccgagg tgttggaaat ctcagatgaa 1600081 aaaattgaag agggcctgat ggtaaaaacg gatcctaaag cggataccac agtcaaagaa 1600141 ggcgccacgg tcacccttta taagagcacc ggaaaagcaa aaacggagat cggtgatgtg 1600201 acaggccaaa cggtcgacca agcaaaaaaa gcgttgaagg accaagggtt taatcatgta 1600261 acagtaaatg aagtgaatga cgagaaaaat gcgggcactg tcattgacca aaatccttca 1600321 gcagggactg agctggtccc gagtgaagat caagtcaaac ttacagtcag tatcggaccc 1600381 gaagacatta cgcttagaga cttgaaaacc tacagtaaag aagcagcgtc tggatatctg 1600441 gaagacaacg gattgaagct tgtagaaaaa gaagcatact cagatgatgt tccagaagga 1600501 caggttgtca aacaaaaacc agcagcaggt acggcagtaa agccgggaaa cgaagttgaa 1600561 gtgacattct ctctcggacc agagaaaaaa cctgcgaaaa cagtgaaaga aaaggtcaag 1600621 atcccctacg aaccagaaaa tgaaggggac gagcttcaag tgcaaatcgc ggttgacgat 1600681 gcggatcaca gcatctctga cacttacgaa gaatttaaga taaaagagcc gactgaacga 1600741 acgatcgaac taaagattga accaggccaa aaagggtact atcaagtaat ggtaaacaat 1600801 aaagttgtca gctacaaaac cattgagtat ccgaaagatg aataacaagg agggaaaata 1600861 tgcctgaggg caaaattatt aaggcgctaa gcggctttta ctatgtactg gatgaatcag 1600921 aggattcaga taaagtaata caatgcagag gaagaggcat tttcagaaaa aacaaaatta 1600981 cccctcttgt cggtgattac gttgtgtatc aagctgaaaa tgacaaagaa ggatatctaa 1601041 tggaaattaa agaaagaacc aacgagctta tcaggccgcc aatttgcaac gttgatcaag 1601101 cggtccttgt tttctcagcg gttcagcctt ctttcagcac ggcattgctc gaccgcttcc 1601161 tggttctcgt tgaggccaat gatattcagc cgattatatg cattactaaa atggatctga 1601221 ttgaagatca agatacagaa gatacgatac aagcctatgc agaagactat cggaatattg 1601281 gttatgacgt ataccttacc tcctctaagg accaagatag tttagcggac atcatcccgc 1601341 attttcagga taaaacaacg gtatttgccg gtcagtccgg tgttgggaaa tcctcgcttc 1601401 tcaacgcgat cagtccggag ctcggattaa gaacaaacga gatttccgag catttgggcc 1601461 gcgggaaaca cacaacccgc cacgtggagc tgattcacac gtccggaggt ttggttgcag 1601521 atacaccggg attcagctcg cttgaattta cagacattga ggaagaagag ctgggctata 1601581 ccttccctga tatcagagaa aaaagctctt catgcaaatt tagaggctgt ttacatctga 1601641 aagagccgaa atgtgcggtg aaacaagctg ttgaagacgg ggaattaaag cagtatcgct 1601701 atgaccatta tgttgaattt atgacggaga ttaaagacag aaagccgagg tattagcata 1601761 atgataaagg ttgcaccatc tattctttcc gctgattttg ccgctttagg caatgagatt 1601821 aaagatgtag aaaaaggcgg agccgattgt attcatattg atgttatgga cggccatttt 1601881 gtcccgaata tcacaatcgg tccgctgatt gtagaagcgg tccggccggt aacggatctg 1601941 ccgcttgatg tccatttaat gatagaagag ccggatcgtt atatcccggc ttttgcgaaa 1602001 gcaggcgcag atatcctgtc tgtgcatgct gaggcatgtc cgcacctgca ccgtaccatc 1602061 cagctcatta aagagcaagg agtgaaggcc ggagtagttc taaacccgca tacccctgta 1602121 caagtcatcg aacatgtttt cgacgatctt gatcttgttc ttttaatgac ggtgaacccg 1602181 ggcttcggcg ggcagaaatt tattcattca gtccttccta aaataaaaga ggttaagcga 1602241 atggcggatg aaaaaggaaa aaaagatctg ttaattgaag tagacggcgg cgtcaacaaa 1602301 gaaaccgctc cgctcgtcat tgaagcgggc gcaaatttac tcgttgccgg ttcagctgtt 1602361 tatggccagt ctgaccgcaa aaaagcaatt tctgaaatca gaggaagtaa ataagcagct 1602421 ttagaaaaga gctgggcata caatagccta agctcttttt cctgtatgca gagaaaggaa 1602481 tcagagatga aaacaattaa tatcgttgcg ggaggcccga aaaatctcat tcccgatcta 1602541 accggctata cggatgaaca cacgctttgg atcggtgttg acaaaggcac cgtcactctc 1602601 ttagatgccg ggatcattcc tgttgaagcc ttcggagatt ttgacagcat aacggagcaa 1602661 gaacgccggc gaatagaaaa agccgctccc gcccttcatg tgtatcaagc agaaaaagat 1602721 caaacagatt tagacctcgc ccttgattgg gcgctggaaa agcagccgga tattattcag 1602781 attttcggca ttacaggcgg cagagctgat cattttttag gaaacattca gcttctgtat 1602841 aaaggtgtaa aaacgaacat aaaaattagg ctgatagaca aacaaaatca tattcaaatg 1602901 ttccctcctg gtgaatatga tattgagaag gatgaaaata agcgatatat ctccttcata 1602961 ccgttttccg aagacataca tgagctgacc ctgaccggtt ttaaatatcc tctaaataat 1603021 tgtcatatta cgctcggttc aacactatgt attagtaacg aactcattca ttcacgaggt 1603081 actttttcgt ttgcaaaagg catattaata atgataagaa gcacggatta agcatgtgct 1603141 ttcattcaat tgctgaaaac aatgaacaag gcggttacgg gacgttatag gaggggacaa 1603201 aaatgaaatt ttacaccatt aaattgccga agtttttagg aggaattgtc cgggcgatgc 1603261 tgggctcatt tagaaaagat taatgcccag gggttcaaag ccctctttca ccacataaaa 1603321 acgcctgcca catatcgggg caggcgttca ttttgttata cacgctcaac tttaccggat 1603381 ttcaaagctc gagcagatac atatactttt ttaggttttc cgttcacaag gatacgaacc 1603441 ttttgaagat tcgcgcccca agtgcgctta gaagcgttca ttgcgtgaga acggttattc 1603501 ccagctgttg tttttttacc tgtgataacg catttacgtg ccatttgttt ccctcctcac 1603561 ttgcacaaaa catctacttt ttaacattca tataatctta gatgctttcg atatggatac 1603621 tttaaataat ttaccacagc taaaaaacgt ttgcaactat tgtttcatca tctttcaaga 1603681 aaattcactt gacatcttgc ggaaacagca gcgctatagt atatgtagag gtacggccag 1603741 cgattattgc ctggtctttt cataatggaa accatatagt agaatagctg taactctatg 1603801 cattcgaagg aggaactagt gtgtccattg aattaagaac gaagtacgga cagattgata 1603861 tatctaatga agtcatcgcg atggttgcag gaggcgcggc ggttgactgt tacggcattg 1603921 tcggcatggc ctctaaaaac cagattaaag acggactgac tgaaatcctt cggaaagaga 1603981 atttcagcag gggtgtccaa gttcgccaag aaggagaaca gatacatatc gacatgtata 1604041 tcattgtcag ctacggcacg aaaatttctg aagtggcaca taatgtccaa acaaaagtaa 1604101 agtacacagt aaatcaaacc atcggactgg cagtggattc tgtcaatatt tatgtccaag 1604161 gcgtacgagt gacgaacccg tagttaggag gagtaggatt gtctatcaga acattagacg 1604221 gcagaacctt tgccgagatg attcttgcgg gagcgcagaa tctgtctcaa aacgccagtg 1604281 cagttgatgc actgaacgtg ttcccggtgc cggacggtga tacgggaaca aatatgaacc 1604341 tgtcgatgac ttccggagca agagaagttg aacaaatgga tacggatgat atcgggaagg 1604401 tgggctccgc gttatctaaa gggctgctca tgggagcacg cggaaattca ggagttatcc 1604461 tatcccaatt gttccgcgga tttagcaaaa acattgaaac gaaaaaagaa attaatgcac 1604521 ttgagtttgc cgctgcgctg caagcaggtg tagacatggc gtataaagct gtcatgaaac 1604581 ctgtagaggg caccatttta acagttgcaa aagacgctgc aaaaaaagca atgatcttag 1604641 cagaaaaaga aaccgatatc actgcgctga tgactgcagt gacagaagaa gcagaggcgt 1604701 ctttaaaccg cacccctgaa ttgctacctg tcctaaagga agtaggagtt gtcgatagcg 1604761 ggggcaaagg cctgctctgt gtgtatgaag gtttccttgc ttcattaaaa ggtgaaactg 1604821 tacctcagaa agcagttctt ccgtcacttg acgacatggt cagcgcagag catcacaaga 1604881 gcgcgcaaag catgatgaat accgaagata ttgaatttgg attctgtacc gaagtgatgg 1604941 ttaggcttga tcagacaaaa agagagttcg acgaaggcac gttcaggcaa gacctcagcc 1605001 agttcggaga ttctctgctt gtgattgcgg atgaatcgct ggcgaaggtt catattcatg 1605061 ctgaagagcc gggaaacgtg ttaaactacg cccagcatta cggtgaattg atcaaaataa 1605121 aaatagaaaa tatgagagaa cagcatacct ctatcatcag tcaagaaagc aaacctgcag 1605181 acaacgaaac accgccggca aaacagccgt atggcattgt gactgtagcg atgggagaag 1605241 gaattgcaga cctatttaaa agcattggcg cttctgttgt gattgaaggc ggccagacca 1605301 tgaacccaag cactgaggat attgttgatg ccgtgaagtc tgtaaatgca gatacggtat 1605361 ttatcctgcc taacaactcc aacattatca tggctgctaa ccaagcggcc agcgtagtgg 1605421 atgaacaggt ttttgtcatt cctgctaaaa cggttccgca agggatgtca gctctgctgg 1605481 cttttaaccc ggatcaagaa gctgaagcga acgaggccaa tatgctaagc gccattcagc 1605541 aagtaaaaag cggacaggtg acgttctcag tcagagatac tcatattgac ggtaaagaca 1605601 ttaaaaaagg cgactttatg ggcattctga atggaacgat tatcggcact tctgaaaatc 1605661 agctgtcagc cgcgaaaatg ctgctgtcag aaatgatcgg agaagatgat gaaatcgtga 1605721 ccattctata tggtgaggat gcgtctcagg aagaagctga gcagcttgaa gcgtttctca 1605781 gtgaaaagta cgaggagatt gaggttgaga tccacaatgg gaaacagcct ctgtattcgt 1605841 atatagtttc agcagaatag aagggcaatt tgcccttcta ttcttatgtc tgcttttaag 1605901 tgcggcagcg ctgtaacgcg cccgcttgcc attttatatc tgatcaatta gtctagaagc 1605961 aaagcgctaa taagctctgg ttcataagga ggaatagcat gaaatacaga agcgtttttg 1606021 atattatcgg cccggttatg atcggtccgt ccagctctca tacagcggga gctgctagaa 1606081 tcgggagagt ggccagaagt ttatttggca gagagcctga gcgcatcatt gtatcttttt 1606141 acggctcgtt tgcggaaacg tataagggcc acggcacaga tgtcgcgatt atcggcggat 1606201 tgcttgattt tgatacattc gatgaacgga ttaaaaccgc tatacaaatt gcagaagcta 1606261 aaggaattga tatagagttt cgggtagaag acgcagtccc ggtccacccg aacacagcaa 1606321 aaatcaccat ttctgatgaa aagggtgagc tggaactgac gggtatttcg attggcggag 1606381 gaaagattga aatcacagaa ttgaatggtt ttgagctccg gctgtcagga aatcatccgg 1606441 ccatattagt tgttcataat gacaagtttg gcacaattgc cggtgttgcc aatgttctgg 1606501 cgaaattttc aatcaacgta ggacatatgg aagtagcccg gaaagatatc ggccagcttg 1606561 cgctgatgac aatagaggtc gatcaaaata ttgacgacca cattctcgac gagctgtcga 1606621 agctgccgaa tattattcaa gtgacaaaga ttgctgacta gcgaaaaggg tcaggaggag 1606681 ccagttatgt ttcgtaatgt aaaagaatta attgagatta ctaaagaaaa acaaatattg 1606741 atctctgatg tgatgatagc tcaagagatg gaagtaacag aaaaaacaaa agaggacatt 1606801 tttcagcaga tggatcataa cctgtctgtt atggaagcgg cggttcagaa aggactcgag 1606861 ggagttacga gccaaacggg cttaacaggc ggagatgccg ttaaattgca ggcctatatt 1606921 cgatcaggaa aaagcctgtc tggcccgctg attttagatg ctgtatcgaa agccgttgca 1606981 acaaatgaag taaatgcagc catgggaacc atctgtgcga caccgactgc aggttctgcc 1607041 ggtgtggtgc ccggtacgtt atttgctgta aaagaaaagc tgaatccaac aagagaacaa 1607101 atgatccgct ttttgtttac agccggggct ttcggatttg tcgtggccaa taacgcaagc 1607161 atttccggcg ccgccggagg atgtcaggca gaggttggat cagcttcagg catggcggct 1607221 gcggctattg ttgaaatggc aggaggaaca cccgaacaaa gcgcggaagc catggccatt 1607281 acattaaaaa atatgctagg cctcgtgtgc gaccctgttg cagggcttgt tgaggtgcct 1607341 tgcgtgaaac ggaatgcgat gggcgcgtca aatgcgatga ttgctgctga tatggcattg 1607401 gcgggcatta caagccgtat tccatgtgat gaggttatcg atgccatgta taaaataggc 1607461 caaacgatgc caactgcact tagagaaaca ggccagggcg gtttagcggc aacaccgaca 1607521 ggaagagaat tagagaaaaa aattttcgga ggagcgctag gttcacgtga aacaacatca 1607581 gcaaactagt atagctaaca ttaagggtat tgggccggaa acagaaaaaa cattgaatga 1607641 actcggtatt tatgacattt ctgatcttct gaattatttc ccttatcgct atgatgacta 1607701 cgagctgagg gatttagaag aagtaaagca tgatgaaaga gtcacagtcg aagggaaggt 1607761 tcattcagag ccttctctta cctattacgg aaaaaaacga aacaggctga cattcaggct 1607821 tctggtcggc cactatttaa tcacagccgt atgttttaac cggccttatt tgaagaagaa 1607881 gctttcgctc ggctctgtgg tgacggtttc aggtaaatgg gacaagcacc gccaaaccat 1607941 ctctgttcag gagttgaaaa acgggccgca tcaagaagac aaaagcattg aaccagtgta 1608001 ttctgtgaaa gaaaatgtta ccgtcaaaat gatgaggcgc tttattcagc aggcgctgac 1608061 ccaatatgca gactcacttc ctgatcctct tccggaaaag ctaagaaaaa gctataaact 1608121 gcctgactat tatcaagcgt taaaagcaat gcaccagcct gaaacaaggg aagcattaaa 1608181 gcttgccaga cggcggtttg tttatgaaga atttttgttg tttcagttga aaatgcaggc 1608241 gttccgaaag gcggaaagag agcagacaca agggatacgg cagcgttttt caaacgaaga 1608301 actcatgaga tttatcaaaa gcctcccgtt tcccctcaca aacgcccagt cacgcgttct 1608361 tcgcgaaata acagcagaca tgtcttctcc atacagaatg aaccgtcttc ttcaagggga 1608421 cgttggatca ggaaaaacgg cagtcgccgc cattgcactg tatgccgcga tcctatccgg 1608481 ataccaagga gcgctcatgg tgccgacaga aattctggcc gagcagcatg ctgattcgct 1608541 cgtttcgcta tttgaaaaat gggacgtcag cgttgctctt ttgacaagct ctgttaaagg 1608601 aaagcggcga aaagaactgc ttgagcgtct tgcggcgggt gagattgata ttcttgtagg 1608661 aacccatgct ttaatccaag acgaggtgga gtttaaggcg ttgagtctcg ttattactga 1608721 tgaacagcac agatttggag ttgagcagcg caaaaagctt cggaacaaag ggcaggatcc 1608781 cgatgttctc tttatgacag ccactccaat cccaagaaca ttagcgatca cagtattcgg 1608841 tgaaatggat gtatctgtca ttgatgagat gccggctgga cgaaagcgaa ttgaaaccta 1608901 ttgggtaaaa catgacatgc ttgatcgtat tttggcattt gtcgaaaaag aattaaagca 1608961 aggcaggcag gcttatatca tctgtccgct gattgaagaa tcagataagc ttgatgtgca 1609021 aaacgccatt gacgtgtaca atatgctttc tgatattttt cggggaaaat ggaatgtcgg 1609081 ccttatgcat ggaaagctgc attccgatga aaaagatcag gtcatgagag aattcagcgc 1609141 aaatcactgt caaattctcg tatcaaccac tgttgtggag gttggcgtaa atgttccgaa 1609201 tgcaacaatt atggtgattt atgacgccga ccgtttcgga ctatcacagc ttcaccagct 1609261 gcgcggccgt gttggacggg gtgagcatca atctttctgt attctgatgg ctgatccaaa 1609321 atcagaaaca gggaaagaac ggatgaggat catgtcggag accaatgacg gtttcgagct 1609381 gtctgaaaag gatctggaac tgagaggtcc cggtgatttc ttcgggaaaa aacaaagcgg 1609441 aatgccggaa tttaaagtgg cggacatggt tcatgattac agagcgcttg aaacggcaag 1609501 gcaggatgct gcgaatcttg tggcttctga cgcgttctgg aaggagccgg aatacgctgt 1609561 gttaagagat gaattgctga agagcggagt aatggacggg gaaaaattaa gctgagtatc 1609621 agaagttttt ggtgttcagc cagaaacaat cgttgcattc caatctatga aattatatac 1609681 tactattagt acctagtctt aattgtccgg atggtgttta gatatgagaa gaaataagag 1609741 agaacgccag gaattacttc agcagacgat tcaagcaacc ccctttatta cagatgaaga 1609801 actagcgggt aaattcgggg tgagcatcca gacgatacgt ttggaccgct tagagctttc 1609861 catacctgaa ctgagagaaa gaattaagaa cgtggcagag aaaacacttg aggacgaagt 1609921 gaagtccctg tcacttgatg aagttatcgg agaaattatt gaccttgagc tggatgatca 1609981 ggcgatatcc attttagaaa taaaacagga gcacgtgttc agccggaatc agattgcgag 1610041 aggacaccat ttatttgcac aggcgaattc tttggccgtt gcagtcattg atgacgagct 1610101 ggcgctgact gcaagtgcag acatccgctt tacaagacag gtaaagcagg gtgaacgtgt 1610161 cgtagcaaaa gcgaaagtga cggctgtcga aaaagaaaaa ggaagaacgg ttgtcgaagt 1610221 gaacagctac gttggcgaag aaattgtttt ttctggacgc tttgacatgt atcgttcaaa 1610281 acattcataa aggtggagca tgcatgagaa tagctgtaga tgcaatggga ggagaccacg 1610341 ctcccaaagc tgttattgac ggagttataa aaggtataga ggcatttgat gatctccata 1610401 tcacacttgt cggtgacaaa acaacgatag aatcacattt aacaactaca tcagatcgca 1610461 tcacggtgct gcacgcagat gaagtgattg agcctacgga tgaaccggtc cgtgccgtgc 1610521 gaagaaaaaa gaactcatct atggttctta tggcgcagga ggttgcggaa aacagagctg 1610581 acgcctgcat ttcagcggga aataccggtg cattaatgac agccggtctc tttattgtcg 1610641 ggagaattaa aggaattgac cgtccggcgc ttgctccgac acttccgact gtttcgggag 1610701 acggatttct tctccttgat gtcggcgcca atgtcgatgc caaaccggag cacctcgttc 1610761 aatatgccat catgggttct gtttattctc agcaagtgcg cggtgtcact tcaccgagag 1610821 tcggactttt aaatgtcgga acagaagata aaaaaggaaa cgaactgacg aagcagacgt 1610881 ttcaaatttt aaaagaaaca gcaaacatca attttatcgg aaacgtggaa gcgcgagacc 1610941 ttttagatga tgtggcggat gttgtagtaa cagacggctt taccgggaat gttacactca 1611001 aaacgctgga aggctctgcg ttgtcaattt ttaaaatgat gagagacgta atgacgtcta 1611061 ctttgacatc caagcttgca gcagctgtgc tgaaaccaaa attgaaagaa atgaaaatga 1611121 aaatggagta ttcgaattat ggcggagcaa gtctttttgg cttaaaagcg cctgtgatca 1611181 aggcgcacgg ctcttcagat tcaaatgctg tattccatgc gattcggcaa gcaagagaga 1611241 tggtcagcca aaatgtggct gcgctcattc aggaagaagt gaaagaagaa aaaacagatg 1611301 agtagtctgg aggtttttac atcatgagta agattgcatt tttattcccg ggtcagggat 1611361 cacaatttat cggcatggga aaagagcttt atgagcaggt gcctgctgca aagcgtctgt 1611421 ttgatgaagc cgatgaaacg ttggaaacaa aactcagctc gcttattttt gagggggatg 1611481 ctgaagaatt aacacttaca tacaatgcgc agcctgcttt gcttacgaca agcatcgctg 1611541 ttcttgagaa atttaaagaa tctggcatta cacctgattt cacagcagga cacagccttg 1611601 gtgaatattc tgcactggtt gcggctggcg ctctgtcttt caaagatgct gtttatactg 1611661 tcagaaagcg cggagagttt atgaatgaag cggtgccggc tggcgaagga gcaatggctg 1611721 cgattctcgg catggatgct gaagcattaa agcaagtaac cgataaagtc acagaggaag 1611781 gcaaccttgt acagcttgcg aatctcaact gtcctggcca aatcgtcatt tccggaacag 1611841 ctaaaggggt tgagcttgca tctgaactgg caaaagagaa cggcgcaaaa cgcgcaattc 1611901 cgcttgaagt aagcggtccg ttccattctg aactgatgaa accggctgct gaaaagctga 1611961 aagaggtatt ggacgcctgt gacataaaag acgctgacgt tccggtcatc tcaaatgttt 1612021 ctgctgacgt gatgactgaa aaagcagata tcaaagaaaa acttattgag cagctttact 1612081 ctccggttcg ttttgaggaa agcattaaca agctgatcgc agagggtgtt acgactttta 1612141 ttgaaatcgg tcccggaaaa gtgctttcag gccttgtgaa aaaagtgaat agacggttaa 1612201 aaacaattgc tgtatcagat ccggaaacga tcgagctggc aattcaaacg cttaaggagg 1612261 agaatgataa tgcttaatga taaaacggct attgtcactg gcgcatcccg cggaatcggc 1612321 cgctcaatcg cccttgatct ggcaaaaagc ggagcaaatg ttgtcgtgaa ctactccggc 1612381 aatgaagcga aagcaaatga agtggtagat gaaatcaaat caatgggcag aaaagcaatt 1612441 gctgtaaaag cggatgtatc aaatcccgaa gatgtacaaa acatgataaa agaaacattg 1612501 tctgtttttt ctacgattga cattctggtt aataatgcgg gaattacaag agacaatctc 1612561 atcatgagaa tgaaagaaga cgaatgggat gacgtcatta acattaacct gaagggtgtt 1612621 ttcaactgca caaaagctgt tacaagacaa atgatgaaac agcgttcagg ccgcattatt 1612681 aacgtatcgt ctatcgtcgg cgtcagcgga aaccctggac aagccaacta cgtggctgca 1612741 aaagccggcg tcatcggttt aaccaaatct tctgctaaag agctcgccag ccgaaatatt 1612801 acggtaaacg caatagcgcc aggatttatc tcaactgata tgacagataa acttgcaaaa 1612861 gacgttcaag acgaaatgct gaaacaaatt ccgctcgcgc gctttggtga acctagcgat 1612921 gtcagcagtg ttgtcacgtt cctagcttca gagggagctc gttatatgac aggccaaacg 1612981 cttcatattg acggcggaat ggtgatgtaa gttttttctc gaaaatttca tcgtagtttc 1613041 tctagttttt taaaaacgaa tccactataa tacttgaggg gaggtgaatt gctatggcag 1613101 acacattaga gcgtgtaacg aaaatcatcg tagatcgcct tggcgttgat gaagcagacg 1613161 tcaaacttga agcttctttc aaggaagact taggtgctga ttccctagat gtagttgagc 1613221 ttgttatgga acttgaagac gagtttgata tggagatttc tgacgaagat gctgaaaaga 1613281 ttgcaacagt cggcgacgct gtgaactaca tacaaaacca gcaataagct gatgctaaaa 1613341 gtcccgccga aacgcggggc tttagccctt tattcgtgca gttattacag catgccgctt 1613401 ttacgcgcgc tgtatccggt ttagtcagag aagcgcggtg aacctgatgt gcctatggag 1613461 gttactatgt caaaacactc acattataaa gataaaaaaa agttctataa aaaagtagaa 1613521 caatttaaag agtttcaaga acggatttcg gttcactttc aaaatgaaaa gcttttgtat 1613581 caagcattta cacattcatc ttatgtgaat gagcatcgga aaaagccgta tgaagataat 1613641 gaaaggcttg aatttttagg tgacgctgtt ttggaactga cgatctccag attcttattt 1613701 gccaaatacc cggctatgag tgaaggagat ttgacgaaat tgagagccgc aattgtttgc 1613761 gaaccgtctc tcgtttcatt ggctcacgag ctgtcattcg gcgatcttgt cctgttgggt 1613821 aaaggcgagg aaatgacagg cggaagaaag cgtcctgctc tattggcgga tgtttttgag 1613881 gcatttatcg gagccttgta ccttgaccaa ggattagagc cggtcgaaag tttcttaaaa 1613941 gtttatgtgt tccctaaaat taacgatggt gctttttctc atgtgatgga tttcaaaagc 1614001 cagctgcagg aatacgtgca gcgggacggc aaaggctctc tggagtataa aatctccaac 1614061 gaaaaaggac ctgcgcacaa ccgtgaattt gaagccatcg tatctctaaa aggtgaacca 1614121 ctcggagtcg gaaacggccg ttcaaagaaa gaagccgaac agcacgctgc tcaggaagct 1614181 ttagctaaat tgcaaaaaca ccatacgaaa caataaaatc ccccttatga ctcaggggga 1614241 tttcagtatg tatgccgtct tatttgacca atgtttatga tagaattgaa atacttatta 1614301 cataaggagg atcgctatgt tcctcaaacg tttagacgtt ataggattta aatcatttgc 1614361 agaacggatt tccgtagact tcgttaaagg cgtgacagca gttgtcgggc cgaacggaag 1614421 cggaaaaagc aacatcacgg atgccattcg ctgggttctc ggcgaacaat cggcacgctc 1614481 tcttcgcggc ggaaaaatgg aagacatcat ttttgctggg agtgattcaa gaaagcgatt 1614541 aaatctagct gaagttacgc ttactcttga taatgatgat catttcttgc caattgactt 1614601 ccacgaggtg agtgtcacaa gacgtgtgta cagatcaggt gagagtgagt ttctgattaa 1614661 caatcagcca tgccgcttga aagatattat tgatttattt atggactctg ggcttggtaa 1614721 agaagcattt tctattatca gccaagggaa agtggaagag atcctgagca gcaaagcgga 1614781 ggatcgccgc agtatctttg aagaagcggc cggggtgctt aaatataaaa cgagaaagaa 1614841 aaaagcagaa aataaactgt ttgagacaca ggacaatcta aatcgggtag aagatatatt 1614901 acatgagctt gaaggacagg ttgaacctct taaaattcaa gcttcaatag cgaaagacta 1614961 ccttgagaaa aagaaagagc tggagcatgt tgaaattgcg ctgactgcct atgatatcga 1615021 agagctgcat ggtaaatggt cgactcttaa agagaaagtg cagatggcaa aagaagaaga 1615081 gcttgctgaa tcgtctgcta tttctgcgaa agaagcaaag attgaggata caagggacaa 1615141 aatacaagcg cttgatgagt cagtagatga gctccagcaa gttttactgg taactagtga 1615201 agagctggaa aagcttgaag gccgtaaaga agtcctgaaa gaacgaaaga aaaacgctgt 1615261 gcaaaaccaa gaacagcttg aagaagccat cgttcagttc cagcaaaaag aaacggttct 1615321 gaaagaagag ctttcgaagc aggaagctgt cttcgaaacg cttcaggctg aggtgaagca 1615381 gttaagggcg caagtaaaag aaaaacagca ggctctcagt cttcacaatg aaaatgtcga 1615441 agagaaaatc gagcagctga aaagtgatta ttttgagctg ttaaacagcc aggcttcgat 1615501 acgcaacgaa ctccagcttc ttgatgacca gatgtcccaa tccgctgtca cattgcagag 1615561 acttgcggac aacaatgaaa agcacctgca ggaacggcat gatatttctg cgcgtaaagc 1615621 cgcatgtgaa acggaatttg cccgaattga gcaggagatt cacagtcaag tcggtgcata 1615681 tcgtgatatg cagacaaaat atgagcagaa aaagcgccaa tacgaaaaaa atgaatccgc 1615741 tctgtatcag gcataccaat acgttcagca agcgagatca aaaaaggaca tgcttgagac 1615801 gatgcaggga gatttctccg gcttttatca aggtgttaaa gaagtgctga aagcgaaaga 1615861 gcgccttggc ggaattcgcg gagcggttct tgagctgatt tctacagaac agaagtatga 1615921 aacggccatt gaaatagcgc tcggcgcttc tgctcaacac gtcgtgaccg acgatgaaca 1615981 atctgcccgc aaagcgattc aatatttaaa gcagaattcc ttcggccggg cgacgtttct 1616041 gcctctttct gttattagag accgccagct tcaaagccgt gacgcggaaa cagccgcccg 1616101 gcattcatca tttctcgggg ttgccagtga acttgtcaca tttgatcctg cgtatcgaag 1616161 cgtcatccag aatcttcttg gaaccgttct gatcacagag gacttaaagg gtgcaaacga 1616221 gcttgcgaag cttctcgggc accggtaccg catcgtaacc cttgagggag atgttgtgaa 1616281 ccccggtggt tcaatgacgg gcggcgcggt taaaaagaaa aataactccc tccttggaag 1616341 aagccgggag ctagaagatg tgacgaaacg gctcgctgaa atggaagaga aaacggcact 1616401 gcttgaacaa gaggtcaaaa cccttaagca ctccattcag gatatggaga aaaaactggc 1616461 tgacttaaga gaaaccgggg aaggcttaag gttaaagcag caggatgtga aaggccagct 1616521 gtacgaactt caagttgccg agaaaaatat caatacccat ttagagctct atgatcaaga 1616581 aaaatctgct ctgtcagaaa gcgatgaaga gagaaaagtg cgcaaacgca agcttgaaga 1616641 agagctctct gccgtatctg aaaagatgaa acagcttgaa gaggacatag acagactgac 1616701 aaaacaaaaa caaacgcaat cctcaacgaa agagtctctc tccaacgagc tgactgagct 1616761 gaagatcgca gcggccaaaa aagagcaggc ttgcaagggg gaagaggaca accttgccag 1616821 attaaagaaa gagctcactg aaacagagct tgcgttaaaa gaagcaaaag aagacttaag 1616881 cttcttaacg tcagagatgt catctagcac cagcggcgaa gaaaagctgg aagaagcagc 1616941 aaaacataaa ttgaatgaca aaacgaaaac gatcgaactg attgcattaa ggcgcgatca 1617001 gcgcatcaag cttcagcatg ggcttgatac gtatgagcgt gagctgaaag aaatgaaacg 1617061 cctgtataaa caaaaaacaa cgctcttaaa agacgaagaa gtcaaacttg gacgaatgga 1617121 agtcgagctt gataatttac tccaatactt acgggaggaa tacagcttgt cctttgaggg 1617181 ggcaaaagag aaatatcagc ttgaaactga tccagaggaa gccagaaagc gcgtgaagct 1617241 gattaaactc gcaattgaag agctgggtac cgtgaacctc ggaagcatag atgagtttga 1617301 gagggtcaac gaacggtaca agtttctgtc ggaacaaaaa gaagatttaa cagaagcgaa 1617361 aaataccttg ttccaagtga ttgaagaaat ggatgaagaa atgacgaagc gctttaacga 1617421 cacattcgtc caaatccgct cacactttga tcaagttttc cgctccttat tcggaggagg 1617481 gcgagctgaa ctgaggctca ccgatcctaa cgatctgctt cattcaggag tcgagattat 1617541 cgctcagccg ccggggaaaa agctgcaaaa cttaaacctc ctgtcaggcg gagagcgtgc 1617601 gcttactgct atagcgctct tattctcaat cctaaaggtt cgtccagtgc cgttttgcgt 1617661 ccttgacgaa gtagaggctg cgctcgacga agcgaatgtg ttccgatttg cgcagtattt 1617721 aaaaaaatac agcagcgata ctcagtttat tgtgattacc cacagaaaag gaacgatgga 1617781 ggaagcggat gtgctttatg gcgtaaccat gcaggaatcc ggtgtttcca aggtaatttc 1617841 agttaagctg gaagaaacaa aagaattcgt tcagtaacga ggaaagaggt taaaagatga 1617901 gcttttttaa aaaattaaaa gagaaaatca caaaacagac agattccgta tctgaaaagt 1617961 ttaaggatgg ccttgaaaaa acaagaaact cctttcaaaa caaagtgaat gatcttgtat 1618021 cccgttaccg taaagtggat gaggatttct tcgaagagct tgaagaggtt cttatcagcg 1618081 cggatgtcgg ttttacaacc gttatggaat taatagatga gctgaaaaaa gaagtcaaac 1618141 gcagaaatat tcaagatcca aaggaagtcc agtcagtgat ttctgagaaa ctggtcgaga 1618201 tttataacag cggagatgag caaatttcag aactgaacat ccaggatggg cgtttaaacg 1618261 taatccttct ggtaggtgta aacggcgtcg ggaaaacaac aacgatcgga aagcttgctc 1618321 ataaaatgaa acaagaagga aaatctgttg tacttgccgc cggagacact tttagagcgg 1618381 gagccattga acagctggaa gtatggggag agcgtacagg agtgcctgtc attaagcaga 1618441 cggcaggaag cgatccggcg gctgtcatct acgatgctgt tcatgctgcg aaagcaagaa 1618501 atgccgatgt attaatttgt gatacggcag ggcgtctcca aaacaaagta aatctcatga 1618561 aagagcttga aaaagtaaaa cgtgttatcg aaagagaagt tcctgaagct ccgcatgagg 1618621 tgctgcttgc ccttgatgcc acgaccggcc aaaatgcaat ggctcaggca aaagaattct 1618681 ctaaagcaac aaatgttacc ggcattgctt taacgaagct tgacggtacg gcaaaaggcg 1618741 gtatcgtcct tgcgattcgc aacgagcttc acatcccggt taaactagtc ggtttaggag 1618801 aaaaagttga tgaccttcag gaatttgatc cagaatccta tgtgtacgga ctcttttcag 1618861 atttagtgga aaaagccgac gattaagaaa aaggccccaa catcttgggg cctttttctt 1618921 ttttatcttc ttacttgata ggcgaaatga taaaggctgt tatcagtgga taccagtctt 1618981 gactcaccag aaaaaactct gaatgggatg atgtcatagt aatgaacgga aacagatgtg 1619041 taatacgtat agtaaccagc agctggcccc aaatacattg gaacctcaaa tgttccgttt 1619101 gcatcagtcg ttcctgaagc agtttgtgtt gtgtttccga ccttcgtgtc cgcttcaaat 1619161 cttacgggcg cgtttggcac tggctgtccg ttttggtcga gtaatttgcc gcttactgta 1619221 atattgtact tgactcgcca atattgacct tgtccgtaat tgattttacc gtatacccct 1619281 ccatctgtgc tgatatttgt gattgaggcc ttataaggtg cctcagcagc gtctgcttgc 1619341 tgtgccggga aacctattgt aaacagggct gccagacata acataaacaa taaaccgatt 1619401 tttttcataa aaatcctcct taaaataggg ttcatataca atatcggaat aaattggatg 1619461 atatttagcg tattttggaa aagttaatcg ccgctttgac aagataaaaa cttgacagtg 1619521 tcattaaaac cgtgtaaact aagttatcgt aaagggattt gacttaacaa aggggagagc 1619581 tcaaatgtca ctcgaaaaga caacgagaat gaattatctg tttgattttt atcagtcgtt 1619641 gttgacgtca aaacagaaga gctatatgtc gctttattat ttggacgatt tctccctagg 1619701 cgaaatagcc gaagaatatg aggtttcaag acaagctgtt tatgataaca tcaaacgaac 1619761 agaagcaatg cttgaacaat atgaagaaaa gctgctcctt ttgaaaaagt ttcaggagcg 1619821 taaagagatg tttaataagc tgaaggagct tgcttccggt tcaaaagaag aggaagaaat 1619881 tacagctctg attgaagcgc ttgagaaatt agattaggag gcggcaaact atggcatttg 1619941 aaggattagc cgaccgactg cagcagacga tttctaaaat ccgcggaaaa gggaaagtca 1620001 gcgaacaaga tgtaaaagag atgatgcgtg aggtccgtct tgcgctgctt gaggctgacg 1620061 ttaactttaa agtagtcaag gattttgtca aaaaagtaag tgaacgcgct gtaggccaag 1620121 acgtcatgaa aagtctgacg cccggccagc aggtcattaa agttgttcaa gaggaactga 1620181 ctgagctgat gggcggcgaa gagagcaaaa tcgccgtcgc aaaaaggccg ccgactgtta 1620241 ttatgatggt cggtctccaa ggtgccggta aaacgacaac aagcggtaag cttgcgaatc 1620301 tgctgcgcaa aaagcataat cgcaaaccga tgctggttgc tgccgatatt taccgcccag 1620361 ccgcaattaa gcagctggaa acactcggca aacagcttga tatgcctgtt ttctctcttg 1620421 gcgatcaggt cagtcctgta gaaatagcta aacaggctat tgagaaagcc aaggaagaac 1620481 attatgacta cgtcattttg gatacggcag ggcgcttgca tatcgaccat gaactgatgg 1620541 atgaactgac caacgtcaaa gaaatcgcga atccggaaga aattttcctg gttgtcgatt 1620601 caatgaccgg tcaggacgct gtgaatgttg ccaaaagctt taatgaacag ctcggtttaa 1620661 ccggtgttgt gttgactaag ctggatggag acacacgcgg cggggctgcg ctttctattc 1620721 gcgctgtcac aaacacgcca attaagtttg caggtttggg cgaaaagctt gatgcgttag 1620781 agccgttcca tcctgaacgc atggcatcaa ggattctcgg catgggcgac gtgctgacat 1620841 tgattgaaaa agcacaggcc agcgttgatg aagacaaagc caaagagctg gaacaaaaaa 1620901 tgagaacgat gagcttcaca ttggacgatt ttctggagca gctcgggcaa gtcagaaaca 1620961 tggggccgct tgatgagctt ctgcaaatga tgccgggtgc aggtaaaatg aagggcctga 1621021 aaaacatcca agttgatgaa aaacagctga atcatgtgga agcaatcatc aaatcaatga 1621081 ctgttcttga aaaagaacag ccggatatta tcaatgccag ccggcggaag cggattgcaa 1621141 aaggaagcgg gacatccgta caggaagtca accgtctgct taagcagttt gatgaaatga 1621201 aaaaaatgat gaagcagatg acaaacatgt caaaaggcaa gaaaaaaggg tttaagctac 1621261 cttttatgta atcggttata catgataaaa ccgttgttaa gaaaaaacac tttacaaaca 1621321 cttttatcat tgttaatata ctatcttgtt gaaatatttt cggaggtgct agtaaaatgg 1621381 cagtaaaaat tcgtttaaaa cgtatgggag caaaaaaatc tcctttctat cgtattgttg 1621441 tagcagattc tcgttcacca cgtgacggcc gtttcatcga aacagtcgga acttacaacc 1621501 cggttgcaaa accagcggaa gtaaaaattg acgaagagct tgctcttaaa tggcttcaaa 1621561 ctggagcgaa accatctgat acagttcgca acttgttctc tagccaagga atcatggaaa 1621621 aattccacaa cgctaaacaa ggcaagtaat gactgatcaa cacttggaag atttgattgt 1621681 ccacattgtg acgccgcttg ttgatcatcc agatgacatt cgcgtcataa gagaagaaac 1621741 cgatcaaaag attgcgctgc gcttatctgt ccataagtca gataccggta aagttatcgg 1621801 aaagcaaggc cggactgcaa aagcgattcg aacagctgta tttgcagctg gcgtacagtc 1621861 ttctaagaaa gttcaatttg aaatatttga ctaaaaggga gagggccggc acctcccctt 1621921 tttttacacg caaaaaaagg gtaaactgat agaagcttag gcaaaataga aaagcctgga 1621981 cgagtaaaag ttttaaaagc ggggagcttg gtgcgatgca aattattcac cgtgtagccg 1622041 ttatgcaagt cttaaccgag cgcagtaaag aaaagctttt agcttctttt gctgagaaga 1622101 aacaaatgct tgaacgagaa tgcagccagc tctattttca gcttagaaaa catgagaaag 1622161 aacagcaaaa ccctaatatg attgaacaat ttaaaaaggc aatagaaaag cgaaaagatg 1622221 atataaaaat cattgatttt caaattgctc aagtacatac attgccgctt ggcagtgagt 1622281 tgaaagaaaa ggaagtcgat gcgctgctga cgattgaagc cggggatgac tggcatgaga 1622341 aaacagcagc gaacaccatc gtcataaaag acggaaaagt aattgaaatt cgccagaggt 1622401 gatcatatga caaagcgatg gtttaatgta ggcaaaatcg taaataccca cggaatcaaa 1622461 ggcgaagtgc gggtgatttc aaaaacagat tttgccgaag aacgatacaa gccgggaaac 1622521 acgctgtatt tgtttatgga cggccgtaac gaaccagtgg aggtaacggt aaacacacat 1622581 agactgcata agcaatttca tctcctgcag tttaaagaaa gacaaaacct aaatgaagta 1622641 gaagagctga aaaacgcaat cattaaagtt cctgaagaag aattaggaga gctgaatgag 1622701 ggtgaatttt atttccacga aattattggg tgtgaagtat ttactgaaga aggcgaactc 1622761 atcggaaagg tcaaagaaat tttgacgcct ggagccaatg acgtttgggt catcggacga 1622821 aaaggaaaaa aagacgcact cattccttac attgaatcag tggttaaaca tatcgatgtc 1622881 agggaaaaga aaattgagat tgaactcatg gaagggttaa tagacgaatg aaaatcgatt 1622941 ttttgacgct gtttcccgaa atgtttgaag gcgtgctcgg ctcatcgatt cttcaaaaag 1623001 cccaggaaaa agatgcggtg cagtttcaag tcgtaaattt ccgagagtac tctgataaca 1623061 agcacaatac tgttgatgat tatccttatg gcggcggggc aggcatggtt ctcaagcccc 1623121 agcctgtttt tgacgcggtc gaggacctga catcaaaggc agccgctgct ccgcgtatta 1623181 tcctcgtatg cccgcaaggt gagcgtttta cccaaaaaaa agccgaacaa ttagctaagg 1623241 aagagcattt gctgttcatt tgcggccact atgaaggcta tgatgaacgc attcgcgagc 1623301 acttggtaac ggatgaaata tcaattggcg actttgttct gacgggcggt gagctccctg 1623361 caatgatgat cgcagacagt gtggtcagac tgcttccggg tgtactgggt aaagaggctt 1623421 cccatattga ggattccttc agcaccggac ttttagagca cccgcattat acaagaccgg 1623481 cagattacaa aggtttaaaa gtgcctgaaa cactcttgtc aggaaaccat gcaaaaattg 1623541 aagaatggcg gaataaagaa tcgatcagaa ggacctacct aagacgtccg gatctgttga 1623601 aagaccaccc gcttacagag cagcaaagaa agtggatttc tgaatgggaa aaagaataga 1623661 ttttattgca taggctatga aattgtgata agatactact tgtggcttaa gcgggcttat 1623721 ccgctgcaag cttgaaaacg atgttccgct gtgccggttt ttgtggccaa gagcatctgt 1623781 tggaaggagt tgaaaacgat gcaaaaacta attgaagata tcacaaaaga acagcttcgt 1623841 actgatcttc ctgcgttccg tcctggtgac actttacgtg tacacgttaa agttgttgag 1623901 ggtaaccgtg agcgtatcca gatctttgaa ggtgttgtga ttaagcgtcg tggtggtgga 1623961 atcagcgaaa cgttcacagt tcgtaagatt tcttacggtg ttggcgttga acgtactttc 1624021 ccagtacaca caccaaaaat cgcgaaaatc gaagttgtac gttacggtaa agtacgccgt 1624081 gctaaacttt actacctgcg tgaacttcgc ggaaaagcgg ctcgtattaa agagatcaga 1624141 cgataatgat aacgaacgaa aagagcttgt tacctgtaac aagctctttt tttatacaga 1624201 atttgaaaat gccggacagg catcgtaaaa tacataaagg acaacaatga atcatgcata 1624261 ctgaagataa aggcggtgtt cgtgtcacat gacaattcaa tggttcccgg gccatatggc 1624321 aaaagcaaga agggaagtaa ccgaaaaatt aaaattaatc gatatcgtat atgaattggt 1624381 agatgccaga attccaatgt catcaagaaa cccaatgatt gaagatattc taaaaaacaa 1624441 gccgcgaatt atgctgttaa acaaggctga caaagcagat gcggcagtta cacagcagtg 1624501 gaaagagcac tttgagaacc aggggatccg ctctctgtct attaattctg taaatggaca 1624561 agggttaaat caaattgtgc ctgcatcaaa agagatcctc caagaaaaat ttgaccggat 1624621 gcgtgcgaaa ggtgtgaagc cgagagcgat tcgcgctttg attatcggca ttccaaacgt 1624681 cggaaaatca acgctcatca accggcttgc aaagaaaaac atagcaaaaa cgggagacag 1624741 acctggtatt acgacttctc aacagtgggt caaagttggg aaagaattag agctattaga 1624801 tacaccggga attttgtggc ctaaatttga ggatgagctt gtcggtttga gactggcagt 1624861 caccggggct attaaagact cgattatcaa tttgcaggac gtggccgtgt ttggtcttcg 1624921 ttttctcgaa gaacattacc cagaacggct taaagagcgt tatggccttg atgagatccc 1624981 agaggacatt gccgagctgt ttgatgcaat aggtgaaaag cggggctgtc tcatgagcgg 1625041 tgggctcatc aactacgata agacgactga agtcatcatt cgcgatattc gcactgaaaa 1625101 gttcggcagg ctgtcatttg aacagccgac gatgtaaagg cgcgcagaaa tgcgggtctt 1625161 tattttttct tggctgaacc gatacataca gtaagggaga agagaaagtg aatacattaa 1625221 ccgtaaagga cattaaagac cgtttgcagg aagtgaagga tgcacaagac ccatttattg 1625281 cccaatgcga aaacgacccg agaaaaagcg ttcaaacgct tgtagagcaa tggcttaaaa 1625341 agcaagcgaa agaaaaagcg ctgaaagaac aatgggtgaa tatgacttcc tatgaaaggc 1625401 tggcaagaaa caaaggattt cgcttgattg caggtgttga cgaggtcggc cgggggccat 1625461 tggcaggacc agttgtcgcc agcgcagtca tccttccaga ggaatgtgaa atacttgggc 1625521 tgacagactc caaaaagctt tcagagaaaa aacgcgagga atattacgag cttattatga 1625581 aggaagcact ggcggtcggg ataggaattg tagaagctac tgtgattgat gagatcaata 1625641 tatatgaagc ttcaaaaatg gcaatggtga aagcgataca ggatttgtcg gatacacctg 1625701 attatttgct tgttgacgca atgacacttc cgctcgacac ggctcaggcg tcaattataa 1625761 aaggcgatgc caaaagcgtg tctattgcgg caggtgcgtg tatcgcaaaa gtgacgaggg 1625821 accgaatgat gagcgcttat gccgaaacgt atcccatgta cggctttgaa aaaaataaag 1625881 gctatgggac aaaagaacat ttggaagctc tcgctgcata cggcccaact gaattgcacc 1625941 gcaaaacttt cgctcctgtt caatctttca gataaatcac catggacaag gaggcacctt 1626001 tttaaaatga acatacgaaa tgatgtgcaa aaggcgctgc agcacctttt cgggcgtaca 1626061 gccgtcccgc aggaaacatc aaaagtaaac gaagcgctaa acggggagaa gcgtctcctc 1626121 ttaggaaaag tgcttcgttt actaggagat cagcatgccc tgatccaagt cggcaatcaa 1626181 actgttcagg gaaaacttga aactcagctt cgtcctcagg catactattg gttttcctac 1626241 gaaaaaaaaa cggcagagca aacaggccgt cttcaggtcg ttcaaagctt tgatcaaaat 1626301 cctaaaacca ttcaggatgc agctggcaaa cttttaaatg ctatttcagt gaagacgtca 1626361 aacgcagctc tcatgatgac aggagcgatg ctgaaaagca aaacacccgt aacagaaaat 1626421 gatatcaaaa cagctgtccg ctggatggac acgctgcctt cgcaagacac aaaaaaagca 1626481 gttgaaacgg ttctcttcgc tttaaagcgt gatcttccca ttcactccga gattttgaat 1626541 ggtgttcacg ctgtgaaatc gcctgttccg ttgcatcagc acgtatccca gctgctacag 1626601 gcaatcgacc aaaaccctca gcagagccaa atgatgtcaa agctaaagga agcagtcacg 1626661 gtgcttttaa atagtgaaat cgatgtccat gcagaacggc tgattgataa gcttatttct 1626721 ttaaccgaca atacgaaagc accttctccg acgaatacag ctggaagcag ggagcttagc 1626781 acaccagctg gctcccccgg aaaagccagc ctgccgattg caaatcacac agcagaacag 1626841 ggaagcatac aagaagagcc tgttaaaaca gcagcagaca ttccaattaa agaagcccgc 1626901 cagctgctgg tgaagctgac ggaatctgct gaaaaaaaca gtctccaaat tgtgaaagaa 1626961 gcagcaaatt ggattaaagc ggctgcttca tcgggtgata gtaagtcact tgcagcttca 1627021 gctgttttac aggcggcaca agtcacagat caggaagccg aagtcttttt aaaggctgtt 1627081 cagcagacag caccccattt ggcggataag gcagatgttc tttctttctt atccaaagtg 1627141 aaaacggcaa tcggcgcaag ggacgaggtt gcgttcatta aagcgtttga acaaggaagc 1627201 gcagtcacat ctggcgaaat gcaatccatc aagctggctc tttctgcctt aagagcatcg 1627261 catgaggtag ccgaaccagt caaacaagaa gccgatcagc tttttcataa attaaatggc 1627321 cagcttttca tgcagcagga ccatccatca tacagccaaa ttgtaatgtc atttccgatg 1627381 ttttcgaagt caggggttca ggacatgact gttctgttta aaggaaagaa agaagcggat 1627441 ggaaagcttg atccttccca ttgccgcctt ttgtttttgc tgcagcttga tacactaaaa 1627501 gaaaccgtcg ttgattgctt ggtacagcaa aaagtcatga ccattacaat agagactgat 1627561 ttcgagctgc aggctgcgat cgatccgatg gtgcccgcgc ttaaacaggg gctaaaggaa 1627621 atggggtaca gcctttcagg ggtaaacgct aaaaaaaggg ttcacaccga agaaaaggct 1627681 tcaatcgatc aatatataac aagtatcagt gatcaggaag tggatgtgaa aatatgaaag 1627741 agcagacacc gatcagaaaa gctgttgctc tccattatga cgaacaaaaa gacaaggcgc 1627801 cgagagtgat tgccacaggg aagggccatg tagctgacaa cattataaaa gaagcgaaaa 1627861 aagcaggggt cccgattcaa gaagatcgga cccttgtcga attaatgcgc catttgacgg 1627921 tagatgatca aattcctgaa gctctttatg aaacggtagc cgagattttt tcattcattt 1627981 acaaattgga cgaaagcgta aaaaacaaaa aatagctaaa atattcccca tccttctttg 1628041 aaatttatgt ttttaataaa gtaaaagttt gaatgtttag aaggattaaa agattttgca 1628101 tcgaactgta gacaattctt ccagtattat tatagaatga aagcgcagtc tattttagtt 1628161 ttgttacata agttaggagg atgggaaatg aatatccatg agtaccaggg aaaagaagtc 1628221 ctcagaaaat atggggtatc tgttcctgaa ggtaaagtgg cttttacagc agaagaagca 1628281 gttgagagtg caaagagctt atccagctcg gtttatgtcg taaaggctca aattcatgct 1628341 ggcggtcgag gcaaagctgg tggggtaaaa atagcaaaat cattagacga agtaaaagcg 1628401 tatgccgaag aactattagg gaagacccta gttacacatc agacgggtcc ggacggccaa 1628461 gtaataaaac gcttacttat tgaagaaggc tgcgatatta aaaaagaata ttacatcggt 1628521 ctagtgcttg accgcgccac ttcaagaatc gttttaatgg cttctgaaga aggcggaacg 1628581 gaaattgaag aggttgcgga gaaaacacca gaaaaaatca aaaaagctgt cattgatcca 1628641 gctgttggcc ttcaaggcta tcaagccaga gaaattgcat tcgctattaa tattccaaaa 1628701 gagctcgtgg gaaaagctgc taaatttatg cttggactat ataaagcgtt tgttgagaaa 1628761 gactgctcaa tcgccgaaat caatccgctt gttgtgactg gcgacggaaa tgtgatggcg 1628821 cttgatgcaa aattgaattt tgacagcaat gcgttgtacc gacaaaagga cattatggaa 1628881 tacagagatt tggatgaaga agatccgaaa gaaattgaag cgtccaaata tgatctaagc 1628941 tacatttccc ttgatggaaa tatcggctgt atggtaaacg gcgcgggact tgcaatgtct 1629001 acgatggata ttatcaagca ttatggagga gaaccggcca acttccttga tgtgggcggc 1629061 ggtgcaaccg cggaaaaagt cacggaagca tttaaaatca ttctttctga tcaaaacgtt 1629121 aaagggattt ttgtcaacat tttcggcggc attatgaaat gtgatgtcat cgcagaaggg 1629181 gttgttgaag cgactagaca agttggtttg acattgccgc ttgtcgtccg tcttgaaggc 1629241 acaaacgtgg atctagggaa gaaaatcctt agtgaatcag gattaaacat tacatctgcg 1629301 gaatcaatgg ctgacggcgc gcagaaaatc gtatccttag tttaagaaag aatgaaaggc 1629361 aggggaccaa ataatgagtg ttttcattaa taaagataca agagttattg tgcaagggat 1629421 tacaggttct accgctttat ttcatacgaa gcagatgctt gaatacggca caaatatcgt 1629481 tggcggtgta acacctggaa aaggcggaac agaagcggaa ggtgttcctg tatttaatac 1629541 agtggctgaa gcagttcaaa caaccggcgc taacgcgtct gttatatatg tgcccgcacc 1629601 gtttgcagct gatgcgatta tggaagcggt agatgcggag cttgatctcg tgatttgtat 1629661 cacagaacat atcccggttt tggatatggt gaaggtcaaa cgcttcatgg aaggcaagaa 1629721 aacgagactg atagggccga actgtcctgg tgtcattacg cctgaagaat gtaaaatcgg 1629781 cattatgccc ggatacatcc ataaaaaggg tcatgtaggc gttgtatcac gttcaggaac 1629841 attaacatac gaagcggtgc accagctctc agaagcgggt gtagggcaat ctacagctgt 1629901 tggaatcggc ggcgaccctg taaatggaac aaactttatt gacgttttaa aagcgtttaa 1629961 cgaagatcct gacacacacg cagtcatcat gattggcgaa atcggcggta cggccgaaga 1630021 ggaagcggca gagtgggtaa aagccaacat gacaaaaccg gtagtcggtt ttattggcgg 1630081 taaaacagca cctcctggga agcgcatggg gcatgcaggc gccattattt ccggcgggaa 1630141 agggacagct gatgaaaaaa tcaaaaccct taatgcatgc ggaatcgaag ttgcagagac 1630201 accttctgtc atgggtgaaa ccttaatcaa ggtgctgaaa gagaagaact tgttcgaaac 1630261 ttgtaaaacg cattaataaa aaagggacag ccgtcaaggc tgttcctgct ttttctaaca 1630321 aaaggaggtc aatctattgg atcaggccgc tgtctgccta acgatttgca gaatcaatca 1630381 attattatcc ccatcccttc tattaaaatg gtggaaagcc gatccgtcta tgtcgctgac 1630441 atcacccgtg ttacaaacgg ttactcgtga tcaaataaaa gcagctgcat taaaaaacga 1630501 aatagaacaa ttttatccaa agctcccgcg tgtacttgct gcttatcgtg agcaaggcat 1630561 taacaccatc cctatttctt caaagcaata tcctttctgg cttaaaagca tttatgatcc 1630621 ccctgccgta ctgtttgcaa aaggtgatat gactcttctt tcgaaaggga gaaaaattgg 1630681 aattgtaggc acaagaaatc caacagctta tgggaaacaa gttgtcaatc atcttacaaa 1630741 agagatctgt cgtaaaggtt gggtgattgt cagcggactg gcgtctggga tagacggaat 1630801 gtcccatgct gcaagtatta aggcgaaggg gcggacaatt ggcgtcattg caggcggatt 1630861 tcaacacatt tatccccgag aaaaccttca gttagcagat cacatggcta aacaccatat 1630921 cctgctgtca gagcacccac ctgaaactaa accccaaaaa tggcatttcc ctatgagaaa 1630981 ccgtattatc agcggactaa gtgaaggcgt tattgtcgtt cagggcaaag aaaaaagcgg 1631041 ttcgctgatt actgcctatc aagcattgga acaagggaga gaggtatttg ccgtacccgg 1631101 ttcattgttt gacccttacg ccggaggtcc tataaaactg atccagcagg gggctaaagc 1631161 catatggtca gcagaggata ttttcgagga acttcctgag agaaacgttc aatatacgga 1631221 acccttttga attatcgttt gacaaacggt attgtaatat ttaataatag tgaggattta 1631281 aagttgcata ttgttttcta tttaattaat gacgttcatg ataaagaatg aaatgttgaa 1631341 agccaaataa agacagctgc aaaaataaaa ttgaaatatc ttgaaaagag agagaacacc 1631401 tcttgagggg gatgaaaatg tctgattatc tagtcatcgt ggaatcgccc gctaaggcga 1631461 aaacgattga acgttactta ggtaaaaaat ataaagtaaa agcatcaatg ggacatgtcc 1631521 gggatcttcc aaaaagtcaa atgggagttg acatagaaca gaattttgaa ccgaaatata 1631581 ttaccattcg aggtaaaggc ccggtattaa aagagctgaa aacggctgcg aaaaaagcca 1631641 aaaaagtgta tctcgcagct gaccccgaca gagaagggga agcgattgca tggcatttgg 1631701 cacacagtct tgatttagat ctcaactcag actgccgtgt ggtgtttaac gaaattacaa 1631761 aagacgctat taaggaatcg tttaagcatc cccgcatgat caatatggat ttagtggatg 1631821 cacagcaagc gagacgtatt ttagacaggc ttgtcggata taaaatcagt ccaatcttat 1631881 ggaaaaaagt caaaaaaggg cttagcgcag gacgcgtgca atccgttgcc ctccgtttga 1631941 ttattgaccg tgaaaaagag attaacgact ttaagcctga ggaatattgg acaattgacg 1632001 gtacgttctt aaaaggtcaa gaaacctttg aagcgagctt tttcgggaaa aacggcaaaa 1632061 aacttccttt aaatagtgaa gctgatgtaa aagagattct ttctcagctc aaagggaatc 1632121 aatatacagt tgaaaaagta accaaaaagg aacgcaaacg taatcctgct ttgcctttta 1632181 ccacttctac cctgcagcag gaagcggctc gcaagctcaa tttcagagcg aagaaaacga 1632241 tgatgattgc acagcaatta tatgaaggaa ttgatttagg aagagaagga acggttggtc 1632301 tgatcacgta tatgagaacg gattcaaccc gtatttcaaa tacggctgtt gatgaagcag 1632361 ctgcatttat tgatcagaca tatggaaaag agttcctagg cggaaaacgg aagcctgcga 1632421 aaaagaatga aaatgcccag gatgcccacg aagcaattcg gccgacatca gttcttagaa 1632481 aaccaagtga attaaaagca gtcctcggca gagaccaaat gagactgtat aaattaattt 1632541 gggagcgttt tgttgccagc caaatggcac cggctgttct cgatacaatg agtgtcgacc 1632601 tgacaaacaa cggtttgaca tttcgtgcaa atggaagtaa agtcaagttt tccgggttta 1632661 tgaaggtgta tgttgaagga aaagacgatc aaatggaaga aaaagaccgg atgctgcctg 1632721 acttacaaga aggcgacacg gtattatcaa aagatataga acctgagcag cattttaccc 1632781 agccgcctcc gcgatatact gaggcccggc ttgttaaaac ccttgaagaa cgcggtatcg 1632841 gccgtccatc cacatatgct ccgacacttg atactattca gcggcgcggc tacgtggcat 1632901 tggataataa acgtttcgtt ccgactgaat taggtcagat cgttcttgac ttgatcatgg 1632961 agtttttccc tgagatcatt aacgttgagt ttacagctaa aatggagaga gatcttgatc 1633021 atgttgaaga aggaaatacc gaatgggtca agattatcga taatttctac accgattttg 1633081 aaaaacgcgt caaaaaagcc gaatcggaaa tgaaggaagt tgagattgaa ccagagtatg 1633141 ctggagagga ttgtgaattg tgcagttctc caatggtata taaaatggga cggtacggta 1633201 aattcttagc ttgctccaac ttccctgact gccggaacac gaaaccgatt gtgaaacaaa 1633261 tcggtgtgaa gtgcccgagc tgcggagaag gaaacattgt tgagcgaaaa tcgaaaaaga 1633321 aacgggtgtt ttacggctgt gaccgttatc cggactgtga attcgtatca tgggacaaac 1633381 caattgaacg aaaatgcccg aaatgcggaa aaatgctcgt cgagaaaaaa ctcaaaaaag 1633441 gtatacaagt ccaatgcgtg gaatgcgatt ataaggaaga accacagaag tagcggtgag 1633501 cagggtcttg ctcaccttct ttgtgtgtta aaagaaggcc ttgaataata aactaggaga 1633561 tgtgaaagat gaaccaacaa acagtgaatg taatcggagc cggactcgca ggaagtgaag 1633621 cagcatggca gcttgccaaa cgtgggattc aagtcaaatt gtatgaaatg cggccagtta 1633681 aacaaacgcc tgcgcatcat acagataaat ttgctgagct tgtctgcagc aactctcttc 1633741 gctctaatac acttgctaac gctgtcggtg tattaaagga agaaatgcgt gcgcttgatt 1633801 cagccattat cgctgcggct gacgaatgtt cggtgcctgc cgggggcgct cttgcagtag 1633861 accgtcatga atttgccgca agtgtgacaa atcgggtgaa aaatcatcca aacgtaaccg 1633921 ttattaatga agaagtgact gaaattcctg aaggccctac tatcatcgca acgggtccgt 1633981 taacatctga atcgctgtct gcccagctga aggagctgac tggagaggac tatttatatt 1634041 tttatgacgc agcggcgcca attgtagaaa aagacagcct tgatatggat aaagtgtacc 1634101 tgaaatcccg ttatgataaa ggtgaagcag catatttgaa ctgcccgatg acagaagaag 1634161 agtttgaccg ttttcatgaa gcattaacat cagcagaaac agtgccgtta aaagaatttg 1634221 aaaaagagat tttctttgaa ggctgcatgc cgattgaagt catggcaaaa cggggtaaga 1634281 aaacaatgct tttcggtccg atgaaaccag ttggtctaga gcatcctgtt acaggaaaac 1634341 gcccttatgc cgtcgttcag ctcagacagg atgatgctgc gggaacactt tataatattg 1634401 taggattcca gacacattta aaatggggag accaaaagga agttctcaag ttgattccag 1634461 gacttgaaaa tgtagaaatc gtcagatatg gcgtgatgca tagaaacaca tttattaact 1634521 ctccaagcct gttaaagccg acttatcaat ttaaaaaccg cagtgatctg ttctttgcag 1634581 gccaaatgac gggagtagaa ggatatgtgg aatcagctgc ctcaggactt gtagcaggca 1634641 ttaatgcggc gaagcttgta ttgggagaag agcttgtgat cttccctcag gaaacagcaa 1634701 ttggcagtat ggcacattat attacaacaa caaaccagaa gaacttccag ccgatgaatg 1634761 caaactttgg gcttttgaaa gaattgccag ttaaaattaa aaataaaaaa gaacgaaatg 1634821 aacaatacgc gaaccgtgcg attgaaacaa ttcaaacaat ttcgaaaaca atataggtat 1634881 tgattgcaac ctgagcgcga tttgtgatac catttaaaag cccttcctgg ggaggtatta 1634941 ggcatggaga atgttaagaa tttcgtaaag ttattcgttg aatatttaca aattgaaaaa 1635001 aattattcac aatatactat tgtgaattat gtggattcaa ttgaagaatt cgagactttc 1635061 ctgcgcgttc aaggtataaa tggatttgaa gaagctgcat atcaagatac taggattttt 1635121 ttgacagaag cctatgaaaa aggtttatcg agaagaacaa taagcaaaaa gatatctgca 1635181 ttaagaagct tttataagtt tctgatgcgg gaaaagctta ttgaagaaaa tccgtttcag 1635241 cttgttcatc tgccaaaaca ggagaaacgg ataccgaagt ttctatatca aaaagagctt 1635301 gaggagctgt ttgaagtttc agatataagc cagccggccg gaatgaggga tcaagcgctg 1635361 ttagagctgc tctatgccac tggaatgagg gtcagtgaat gctgttccat aactattaac 1635421 gacgttgatt tatttatgga cactgtgctt gttcacggta aaggcaagaa gcagcgctat 1635481 atcccctttg ggtcttatgc ccgcgaagcg ttgaaggtat acatgaatag cggaagacag 1635541 tgcttgctga tgaaggcaaa agaacctcat gatctattat tcgtaaatca aagaggcgga 1635601 ccgcttacag cccgtggcat cagacatatt ttaagcgggc ttgttcaaaa agcgtcaagc 1635661 actttacata tccatccgca tatgcttcga catacgttcg ccacgcatct gttaaatgaa 1635721 ggagcggatt tgagaagcgt tcaagaactg ctcgggcatt ccaatctgtc ttctacacag 1635781 atatacacgc acgtttcgaa ggaaatgttg agaaacacat atatgtctca ccatccaaga 1635841 gcatttaaga aaaattaaag gaggcccttt atgtcatctt ttcatgcgac cacaatattt 1635901 gccgtacagc ataaaggacg aagcgctatg tccggagacg gccaagtaac atttggtcag 1635961 gctgttgtca tgaaacacac ggcacggaaa gtgagaaaac tgtttaacgg caaagttctt 1636021 gctggttttg cgggatctgt tgcagacgct ttcactttat tcgaaaagtt tgaagctaag 1636081 cttgaagaat ataacggcaa cttaaaacgg gcggctgttg agcttgcaaa ggaatggcgc 1636141 agtgataaag tgctaagaaa gctcgaagcc atgctgattg ttatgaatca ggatactttg 1636201 cttctcgtat cgggaacagg cgaggtgatc gaaccagatg acggcattct cgcgattgga 1636261 tcaggaggca attacgcttt ggcagcggga agagcactga aaaagcatgc cggggaaagc 1636321 atgtctgcaa gtgagattgc cagagccgcg ttagaaacag caggcgaaat ttgtgtttac 1636381 acgaacgatc aaatcatact ggaagagctt gaatagaaag gacttgaggc gcatggaaaa 1636441 aaaaccgtta actcctagac agattgtaga tcggttagac caatatattg tcggtcagca 1636501 aaatgcgaaa aaagctgtcg ccgtggcatt aagaaaccgc tatagaagaa gtcttctgga 1636561 tgaaaagctg aaggacgagg tcgttccgaa aaacatttta atgatgggtc ctaccggcgt 1636621 cgggaaaact gaaattgcca gacgaatcgc taagctttca ggtgcgccat ttatcaaaat 1636681 tgaagctact aaatttaccg aagtcggcta tgtaggcaga gatgttgaat caatggtcag 1636741 agatcttgtg gagacttctg ttcggcttat aaaagaagag aaaatgaatg aagtaaagga 1636801 acaggcagaa gaaaatgcaa acaaacgcat tgttcgtctg ttagttcctg ggaagaaaaa 1636861 acaatctggt gttaaaaatc cgtttgaaat gttttttgga ggcagccagc cgaatggtga 1636921 agatgaggcg gagagccagg aagaagcaaa catcgaagaa aaaagaaaac gaatggcgca 1636981 tcagctggct ttaggagagc tcgaagacta ctatgtaaca gtagaagtcg aagaacagca 1637041 gccttctatg tttgacatgc tgcagggctc gggtatggag cagatgggta tgaacatgca 1637101 ggatgcgctg agcggattaa tgccaaagaa aaagaagcgg cgcaaaatga cagtcagaga 1637161 agccagaaaa gtcctgacga atgaagaagc aagcaaactc atcgatatgg atgaagtcgg 1637221 ccaggaagct gttcagagag cagaagagag cgggattatc tttatcgatg agattgataa 1637281 aatcgcaaag aacggcggtg catcttcttc tgccgatgtt tcaagagaag gtgttcagcg 1637341 ggatatcctt ccgattgttg aaggttctac cgttgtcaca aaatatggtt ctgtaaaaac 1637401 agaccatgta ttatttattg cagcaggagc gtttcatatg gccaaaccgt ctgatttgat 1637461 tcctgagctg caggggcgtt tcccgattcg tgtagaactg aacaaactca cggtagacga 1637521 cttcgtgaga attttggttg agccggataa tgcgctgctg aaacaatatc aggcattatt 1637581 gcagacagaa ggtatatctc ttgaattttc tgacgaagct attcataaga ttgctgaagt 1637641 tgcttatcat gtgaaccagg acacagataa tatcggtgcg agacgccttc atacaatact 1637701 tgaacgccta ttagaagatt tgtcgtttga agctccagat gtaacgatgg agaaaataac 1637761 gattacacca cagtatgtcg aagaaaagct cggaacgata gccaaaaaca aagatttaag 1637821 tcaatttata ttgtgaaaaa tttaatatga ggaatgttta ggaggattat ttatcatggc 1637881 tttattacaa aaaacaagaa ttattaactc catgctgcaa gctgcggcag ggaaaccggt 1637941 aaacttcaag gaaatggcgg agacgctgcg ggatgtaatt gattccaata ttttcgttgt 1638001 aagccgcaga gggaaactcc ttgggtattc aattaaccag caaattgaaa atgatcgtat 1638061 gaaaaaaatg cttgaggatc gtcaattccc tgaagaatat acgaaaaatc tgtttaatgt 1638121 ccctgaaaca tcttctaact tggatattaa tagtgaatat actgctttcc ctgttgagaa 1638181 cagagacctg tttcaagctg gtttaacaac aattgtgccg atcatcggag gcggggaaag 1638241 attaggaaca cttattcttt cgcgtttaca agatcaattc aatgacgatg acttaattct 1638301 agctgaatac ggcgcaacag ttgtcggaat ggaaatccta agagaaaaag cagaagaaat 1638361 tgaagaggaa gcaagaagca aagctgtcgt acaaatggct atcagctcgc tttcttacag 1638421 tgagcttgaa gcaattgagc acatttttga ggagcttgac ggaaatgaag gtcttcttgt 1638481 tgcaagtaaa attgctgacc gtgtcggcat tacccgttct gttattgtga acgcactcag 1638541 aaagctggag agcgccggtg ttatcgagtc tagatcatta ggaatgaaag gtacttatat 1638601 caaggtacta aacaacaaat tcctaattga attagaaaat ctaaaatctc attaatcaca 1638661 aaaagaaccc tttttgaggg ttcttttttt atttcaaata aaggaaatca ataagcttta 1638721 tttcctgggt tgaaagtctt tctatgtaat aattttaata aattttgcat ttttcttcaa 1638781 aaagtttcaa aaatgccgaa aagaaaggag aaaaaacaga aattctgcta ttttcaggct 1638841 tatatcaagg cgagaaatgt agttctaaca atctaggact ttatacctag ttgcaaaata 1638901 gataattgtg aggacatttt tttacacgaa cttcatagac tttatgcctg ttatttctta 1638961 caataagcat atagttttac aattctcgac aaggatattg agggtgaaaa aaactgaaat 1639021 ggaggtaagt ggatttgagc ttattttctg gaacgataca aaatcttgaa aatgccttga 1639081 gcagagcgga tattaagcaa aaagtcataa ctaataatat cgccaatata gatacaccga 1639141 actataaggc aaaaaaagtc tctttccaaa atttattaga tcaagaatcc tcgcgtcttg 1639201 aagcgataaa aacagactat cgtcatgttg atttttctga tactgattcg aattattcaa 1639261 ttgttgcgag cggagataca tcgtatcagc aaaacggaaa caatgttgat gttgacaaag 1639321 agatgacaga attggcgcaa aatcaaatca actatcaagc tttggttgaa agaatgaacg 1639381 gtaaatttaa ttcgctgaag accgtattaa caggaggaaa atgatgacag cttttcatag 1639441 cttaaatgtt tcagcatcgg ctttaacagc tcagcgagtc agaatggacg ttgtatcatc 1639501 taacttagca aatatggata cgacaagagc taagcaggtg aatggagagt gggtgcctta 1639561 cagaagaaaa atggtttccc ttcagtcaaa aggtgaatcg ttctcttcca ttctcaattc 1639621 tcaaatgagc ggaagcggga atgctggaaa cggtgtgaag gtttcaaaaa ttacggagga 1639681 tgattcggat tttaatcttg tctatgatcc gacagaccct gatgcaaacg ctgaaggata 1639741 tgtacaaaag cctaatgttg atccattaaa ggaaatggtt gatcttgtca gcagcactag 1639801 atcatacgag gcgaatgtca cggcgatgaa tgccacaaag ggaatgctga tgaaggcgtt 1639861 agaaatcgga aagtaggtga atgaatgtga ttaatgcaat ttctcctttt caggttcaaa 1639921 atactcaaaa cactcaaaat gcaacaaatc aagtaaacaa tagccaaaaa acagattctt 1639981 caaatcaaac aagcttttcg gagcttttaa aaaactctat tagttcgtta aatgagtccc 1640041 aagtagcttc tgacaacatg actaatgcct tggctgcagg aaaagatgta aatcttgatg 1640101 aggtcatgat cgctgctcaa aaagctagca tctctctaac tgcagcaaca gagttccgca 1640161 ataaagctgt ggaagcttat caggagatta tgagaatgca aatgtagggg gtctgacgat 1640221 ttagagaaag agtggaatga ccgggggtta acatgaatcg tactctaatg caaatgaaaa 1640281 acaaaacgag tgagttttgg aaaaatagat ctaaattaca aaagatttta atggttagtg 1640341 ctttagcggc aattattatt attggaatta ttattagtgt ttttgcttca aattctaaaa 1640401 tggcgccgct gtacaaagat ttgtctgccg aagaagcagg acaaatcaaa gaagaattgg 1640461 atgcaaaaaa agtgccaaac gaactttcga atggcggtac agtgattagt gttccggagg 1640521 atcaggttga ttctttgaaa gtgcagatgg ctgcagaagg acttcctaaa acgggatcaa 1640581 ttgattattc gttttttgga cagaatgccg gctttggttt gacagacaat gagtttgata 1640641 tggtgaaagt gaaagctaca cagacagaac tgtcaaactt gatcaatgaa atggacggta 1640701 ttaaaaattc aaaagtaatg attaatctcc cgaaagacgc tgtgtttgtc ggtgaagagc 1640761 aatctgcagc atctgcatca atcgttttgc agattcaacc gggttataca cttgatcaaa 1640821 gccaaatcaa cggattatat catctggtat ctaaaagcgt gccaaaccta aaagaagata 1640881 acatcgtcat catggaccaa aattctacat actacgacaa atcagacagc gatgcagggt 1640941 cctacgcgga tagttattct tctcagcaag gaattaagtc tcaagttgaa aaagacattc 1641001 aaaaacatgt acagtcactg ctgggtacga tgatgggcca agataaagtc gttgtctccg 1641061 ttacagcaga cattgatttc acaaaagaaa atcggacaga agacattgtc gaacctgtgg 1641121 ataaagaaaa catggaaggc attgcagtca gcgctgaaaa ggtatctgaa acatatcagg 1641181 gcgacggtgc agccaacggc ggaactgccg gaaccggcga ggaagatgtt acaaattata 1641241 aggctgacgg tgaaaatacc gaaagcggga actacgaaaa aaacagcaac aaaatcaatt 1641301 acgaggttaa ccgaattcat aaagaaatcg ctgaaagtcc ttataaggtc agagatttag 1641361 ggattcaagt aatggtagag ccgcctgatg ccaaaaacac tgcgtcgcta tcaactgaaa 1641421 gacaggatga tatacaaaaa atcctttcaa ctgtagtcag aacatctttg gataaagatg 1641481 aaacgcaaaa tcagaattta tctgatgctg atatcaataa taagattgtt gtttccgttc 1641541 agccattcga cggaaaagtc aatttggata caaatacgga agaatcctca ggtatcccgc 1641601 tgtgggcata tattgtaggc ggtgttttaa tcgcagcgat cattgttctg atcattatgc 1641661 ttatcagaaa gaaacgggcg caagaggatg aatttgagga atatgagtat gaggttcctc 1641721 aagaaccaat caatttgcct gatatcaacg aagaggaaaa tgaaacagcg gaatcagtca 1641781 gacgaaaaca gcttgaaaag atggcgaaag acaagccgga agattttgca aaactgctga 1641841 gaagctggct ggccgaggat taggaggaat tagaaatggc gagacgtgat caagataagc 1641901 ttacaggaaa acaaaaagca gccattctca tgatttcctt ggggttagat gtgtcagctt 1641961 ctgtctataa gcacttaacc gatgaagaaa ttgaaaggct tactctggaa atatcaggtg 1642021 ttcgaagcgt cgatcatcaa aaaaaggatg aaatcataga agaatttcat aatatagcca 1642081 ttgcgcaaga ttatatttct caaggcggtt taagctatgc aagacaagtt ctggaaaagg 1642141 cgcttggaga ggataaggcg gagaacattc taaacaggct gacttcttct ttgcaggtta 1642201 aaccatttga ttttgccaga aaagcggagc cagaacaaat tttgaatttt atccagcaag 1642261 agcatccgca gacgatggcg ttaatcttgt cttatttaga tccagtgcag gccgggcaaa 1642321 ttttatccga gctgaaccct gaagtgcagg ctgaggttgc gagaagaatc gcggtcatgg 1642381 atagaacgtc tccagaaata attaacgagg tagaacggat tctggaacaa aaattatctt 1642441 ctgcatttac tcaggattat acacaaacag gcggaattga agctgttgtg gaagtgttaa 1642501 acggggtaga cagagggaca gagaagacga tcttggattc attggaaatt caggatcccg 1642561 atcttgctga agagattaaa aagcggatgt ttgtcttcga agatattgtc acacttgata 1642621 accgtgcaat tcagagagtc attcgcgatg ttgagaacga cgatttgctc ctttcattaa 1642681 aggttgcaag cgaggaagtc aaagaaattg tgttcaacaa tatgtcacag cgtatggttg 1642741 aaaccttcaa agaagaaatg gagtttatgg gccctgtacg tttgaaagat gtagaagaag 1642801 ctcaatcaag aattgtaagc atcgtcagaa agcttgaaga agccggtgaa attgtaatag 1642861 caagaggcgg aggggatgat attattgtct aatatcatta aacaagaatc atctatttct 1642921 ccacaaaagg aaaaaagaaa actttctata caagaggtgc gtattgatca ttctcacctt 1642981 ttgcaggctg aagagaaccc ggaggcgctt atggcccgag tgaaagagga agctgaccgg 1643041 atttctgagc aggcaaacag tcatatagaa aatattcgcc gtcaaattga acaggagaaa 1643101 aacgattggg cggctgaaaa acagaagctt attgaagaag caaaagccga gggctttgaa 1643161 caaggagtag cgctgggcaa agctgaggca atgaaacagt atgcagaact gatcggccaa 1643221 gcaaacagta taactgaaat gtccagaaaa gctgttgagg acaagcttga agacgctaat 1643281 gaagaaatcg ttgagcttgc cgttgcccta gcaaaaaaag tttggcagca aaagtctgat 1643341 gataaagagg ctttcctcct gcttgtacaa caggttataa acgaagtgaa ggaatatgac 1643401 gatatatcaa tttatgttga tccatattac tatgagacaa tctttcagca aaaagatgaa 1643461 atccagcagc ttctttataa agaatgtcgg cttggcatat atgctgatga aaaagctcaa 1643521 aaaggaacct gttatattga aactcctttt ggcagggtag atgcgagtgt tgacacacaa 1643581 ttgatgcaat tgaaagataa acttctgaca gcgctggaag caggtgcagc tgaatgaaga 1643641 cacagagtct gatagattgt atagaaatga cagactcgta taaacggtac ggaaaagtca 1643701 agcgggtaat cggcttgatg attgaatcaa aagggccagc aagctcaatt ggtgacctgt 1643761 gcctgattta tgcaaaagga cagtctggga aagtcattaa agctgaggta gtcggcttcc 1643821 aggaagaaaa tattttgctt atgccttatt tagaggctgc gagcattgca cctggcagca 1643881 ttgtagaagc tactggggaa tcacttcggg ttaaagttgg gaccggactg atcggacaag 1643941 tcatcgatgc ttttggagaa ccgcttgacg gaaagcttct gccgaaaggg ctttcgcctg 1644001 tatcaacgga gcaatcaccg cctaacccga tgaaacggcc gcctatccgt gaaaagatgg 1644061 gtgttggagt cagatcaatt gacagcttgc tgacagtcgg taaaggccag cggattggaa 1644121 tttttgcagg aagcggtgtc ggaaaaagca ccttaatggg gatgatcgcc aagcagacag 1644181 aggctgactt aaacgtcatt gcacttgtcg gagaacgcgg acgagaggtt cgggagttta 1644241 ttgaaaaaga tctggggaaa gaggggctga aacgatcgat tgtagtcgtt gccacctcag 1644301 accagccagc attaatgaga ttgaaagcgg catatacagc gactgcaatt gccgagtatt 1644361 tccgagataa aggccaaaat gtcatgttta tgatggattc tgttacaagg gtggcaatgg 1644421 cgcagcgaga gattggactg gctgcaggag agcctccgac gacaaaaggc tatacacctt 1644481 cagtgttcgc tattttacct cgtttactag aacgaacagg tgcaaacgag catggaacca 1644541 ttacggcatt ttatacagtg ttggtagatg gggatgacat gaatgagccg attgccgata 1644601 ccgtacgcgg aattttagac gggcatattg tgttggacag ggcgcttgcc aataaaggcc 1644661 agtttcctgc agttaacgta ctaaaaagca tcagcagggt gatgtcaaac atttcaacaa 1644721 aacagcatct ggatgcggca aataaattcc gtgaactttt atcgacatat caaaattcgg 1644781 aagatctcat taatatcgga gcttacaaaa gaggatcatc cagagaaatt gatgaagcga 1644841 tacaatttta tccgcagctt attcaatttt taaagcaggg aacagacgaa ccggctttat 1644901 tggaagaaag cattgctgca ttaactagtt tgacaggaaa tgaggaataa acgtggctta 1644961 tcaatttaga ttccaaaagc tgctggaact aaaagaaaat gaaaaagacc aatccttatc 1645021 cgaatatcag caatcagttt ctgaatttga aaacgttgct gaaaaattat atgagaatat 1645081 gagcaaaaag gaattgctgg aacaaaataa ggaaaagaaa ttaaaaagcg gcatgagtgt 1645141 acaagaaatg aggcactacc aacaatttgt ctcaaatctt gataatacga tctatcacta 1645201 tcaaaagctt gtcattatga aaagaaatca aatgaatcaa aaacaagaaa ttttgacaga 1645261 gaaaaacatt gaagtgaaaa agtttgaaaa aatgcgtgaa aaacagttta aaatgtttgc 1645321 tcttgaagat aaagctgcag aaatgaaaga aatggacgat atttcgatta agcagtttat 1645381 gattcaaggc cattaggagc gaatgtaatg tccggcaaaa agaaagaatc aggtaagttc 1645441 cgttcggttt tgcttatcat tatcctcccg ctgatgtttc tattaatcgc aggggggatt 1645501 gttctttggg ctgctggtat caatgtctta aagccgatac aggatgctgc ggcaaaaacg 1645561 ccggttctta aagaattggt ccctgaaacc gaaaataaaa aaggcgcagc atcaagtaag 1645621 gatagcagta atacggcagc tctggaaaag accattaagg atcaaaaaag tgaaatcagt 1645681 atattgaata aagatttaga aacaagtaaa tcagaaatcg acaggctcaa tcaaaagatc 1645741 cgttcacttg aaaagacggc tgaggatcaa aaaaagtcat cagaagatca tactgaagga 1645801 tcagcagact cgaaagcttc ttctgaaaat gacaaagtga tcagtgtgta caaaagcatg 1645861 gacagcggaa aggctgctaa aattattgcc caattaaagg agcaagaagc actgaaaata 1645921 ttgaatggcc taagcaaaaa gcagcttgct gacatattgg cgaaaatgac tcctgagcaa 1645981 gcagcaacct atacagaaaa aattgctgcc agccaagaat agggggaatg aaaggtgaag 1646041 ctgcttgaat tagccggacc tttgctgcaa accacaacgg gttctgccgc taaaaacatg 1646101 aaaagtagcc agggagtttt tcaaaactgg cttatgtctg aggctggatt gaaggaactt 1646161 tcagaacaag gaaagggaac tcctaattct gaagatcagc ttttagcaga tgcgcttaaa 1646221 aagatcggtg aatggctaaa tgcaagtcct gaagatcaag acaaacaaaa tgcggatctt 1646281 ttgcaaacat taagcaaact gacagggaag caattggatg cgaatgctct gcaaatgttg 1646341 caaaatcttt tgcaagcagt tgaatcaaaa atgtcaggcg ggacggatca attgctcaca 1646401 gaaacggaga aaatcttttc agaagctaaa acggctctga gtgccaatga ttctgcttct 1646461 gacattaatg gagcactgaa gtctgataaa gagcaatcaa atcaggaaaa tgaagtatcc 1646521 gagcctgcaa aagagcttat ctatatccag atgttcatta gccagctcgt agaagggaat 1646581 aagctgactg atctcgggaa tggcaatgaa gctcatgcca tttaccaaaa tggagatcaa 1646641 ttcctttctg cattagaaaa gaagggtgta tctcaacaac taattcagga tcttaaacag 1646701 caaatattca ctaaagctga gtcaagttca aaactttact cgatgacagc gtcagagctg 1646761 aaaagttttc aaagcttaat ggatcaaatg tctatgcttc ctcaaaaagg gaccaaagaa 1646821 tggagtttag ctgaaagcca gctgaaagcc ttcttgttat cgaaatcatc cgaatcatca 1646881 caagactttg ggaagagtgt tctcacaccg ctctcgcaga gttcatccag caaaaatgca 1646941 tcggatgttt ctggaagtat tcagcctgta gatagtaaat caggactcca aatgctgttt 1647001 tcggggtatc ggggcatagg aggagttcaa acacttgatc tgcagcagat gtcatctgat 1647061 ataccaaatg ccgaaacaaa aacggtggct gatcaagtga ttaatgcgtg gaagcagatg 1647121 aaatatacgc ctttcggcag atcgacggga agtttcacta ttcggctgaa ccctgaacat 1647181 ttaggatttg tcacaatcaa gctgacaaat gaaaatggaa tgtttcagag taaaatcata 1647241 gcatctagcc aatcagcaaa agaattgctt gaacagcatc ttcctcagct gaagcaatca 1647301 ttgccgaata tggccgtcca aattgaccgt tttactcttc cggtccaaag cggggatcag 1647361 ccgatatacg gccagcttgc tgatgaacag aaacagcagc aagaggggca gagacagcaa 1647421 agacagaaaa agcaatcaaa tgattttggc gatctgctcg atgaagtgtc gatggttgaa 1647481 atggaggaag aagaatgact tctataagtt cagaatataa actgcctgaa aaaacgaaca 1647541 ctgtgtcgac gaacaacagc agcttgggga aagacgagtt tttaaaaata ttaatgactc 1647601 aagttcaaaa ccaagatccg cttaacccga ttgacgataa agaatttatc agccagatgg 1647661 cgactttttc aagcttggag caaatgatga atctgaatac gacaatgact caattcgttg 1647721 aaaaccaaga tccgtttaca acgtatgttg attggatggg aaaagaagta tcttggactg 1647781 atggtaaaag tgcaacagat aaaacaggca cagtaagctc tgttaaacat tttaaaggaa 1647841 attattatct cgttcttgat gatgggaccg agatcagtcc tgcgaatgtc atgtctgtgg 1647901 gacaatcatc taaataaaaa catctggggg aatatattat gttacgttca ctttattctg 1647961 gaatcagcgg tatgaaaaac tttcaaacaa agcttgacgt aatcggtaac aacattgcca 1648021 acgtaaatac agtaggattc aaaaagagcc gtgtgacctt taaagatatg gtaagccaaa 1648081 cgattgccgg cggttctgct gctggtgcaa caatcggcgg aacaaactct aagcaaatcg 1648141 gtttaggttc atcatctggc acaattgata caattcattc aacaagcgcg acacaaagca 1648201 caggaagaac acttgattta gcaattgacg gcgacggtta cttccgaatt gatacaggtg 1648261 acgggacagc ttatacaaga gcagggaact tctatttaga taatactgga acactggtta 1648321 caggtgatgg ctaccatgta ctaaatatga atggcggaac aattaaaatt cctactgatg 1648381 ctcaaagctt tagcattggt tctgatggaa aggtgtcaat tgttgatgct gaggggaaaa 1648441 cacaagacgg gggacaaatc gggattgtta cttttgccaa cagtgatgga ttggataaaa 1648501 tcggaagcaa cctataccgt gaatctttaa actctggaac ggccagtgca gcgaaccagc 1648561 ctggtgacgg cggaactggt gctcttaaat caggatttct cgaaatgtct aacgtcgatt 1648621 taactgacga atttactgaa atgatcgtag cccagcgcgg attccaatca aactcaaaaa 1648681 ttattacaac atctgatgaa atccttcaag aactggttaa ccttaaacgt taaggaggga 1648741 ggggaggcga gtaatcgctt ctccgctgtt ttatgattaa agtaacccgt ttgaacgggc 1648801 agccctttac actgaatgcg ctatttattg aacagattga atgttttccg gatactacaa 1648861 ttactctgtc aaatggtaag aagtttgtag taaaagaaga tgaagaagct gttctggaaa 1648921 agatcgcagc tttctaccga aaaatacaaa tatttgcaat ggatcaagga atagaggaac 1648981 cggaatgaag aaaaagttaa tgatcatatt actaattatt cttatcgtaa ttggtgctct 1649041 cggggcggcg gcttattttg ttttaggcgg aaagtccgaa aaaagtgaag cgaaaaaaag 1649101 tattgatgaa atcgttgcgt cttctgttga tgtagaagag atcacaacaa atttaaagtc 1649161 tgataacatt atccgtcttg ctattaaact tgaaactgat tctgataaat caaaagaaga 1649221 acttgagaaa cgtgatttcc aagtgaaaga cgctgttata tcactgctgg ctgatacgaa 1649281 tgctgatcag attgagggag acaagggaaa agaaaccttt aagaaggaac taaaagataa 1649341 aataaatagc tacctccaag aaggaaaagt agaaaaagtg tatattacct cctttaatct 1649401 gcaataaagc ataatttgac agaatacgga ggtgaggaaa atgtcaggag aagttctctc 1649461 ccaaaatgaa atagatgcac tgctctctgc aatatcaact ggtgaaatgg acgctgaaga 1649521 gctgaaaaaa gaagaaaaag agaagaaagt caaggtttat gatttcaaac gtgcgctgcg 1649581 gttttctaag gatcagatcc gcagtttaac gagaattcat gacaattttg caagacttct 1649641 taccactcat ttttctgctc agctcagaac ctatattcac atatctgtca gttctgttga 1649701 tcaggttccg tatgaggaat ttatcagatc gattccaaac atgacgattc tgaatctatt 1649761 tgatgttcat ccgatggaag gaagaattat gatggaggtc aaccccacga tagcttatac 1649821 gatgatggat cgagtcatgg gcgggattgg aatcagtcat aacaaggttg acagtttgac 1649881 agaaattgaa acaaaaatca tttctaattt atttgaaaat gcactgggta attataaaga 1649941 agcttggcag tcaattgctg atattgaacc ggaaatgact gagtttgaag tgaatccgca 1650001 atttgttcag atggtatctc ctaatgaaac agtcgtggtg atctcgctca atactcaaat 1650061 tggtgaaatc agcggtgtca ttaatctctg tatcccgcat attgtactcg agccgctcat 1650121 accgaagctt tcagtccact attggatgca atcagaccga aatgagccaa agcctgagga 1650181 aacaaagtcg cttgaaaaac gtatcatgac agcacaaata cctgtcgtgg ccgagctcgg 1650241 cacatctgaa ctgacgatag aagagttttt aagtttagaa gtcggagact gcataacttt 1650301 ggacaaatca gtcacggatc ctcttactgt attggtcgga gataagccga aatttttagg 1650361 acaagccggc cgggtgaatc gaaaacaggc agtgcaaatt ttagatcacg acataagagg 1650421 tgaacaagat ggagaataat agattatctc aagatgagat tgacgcgctt cttaacggta 1650481 ctggcagcac gcttgatgag ccagagattc cggaagtaga tgacttatcg gaaatggagc 1650541 gtgatgcgat cggtgaaatc ggtaatattt cattcggcag ttctgcgaca gcactgtcaa 1650601 cgcttttaaa tcaaaaggtc gatattacga ctccaagcgt aacggtcatt ccaagaagta 1650661 aaatcagcga tgcgtttcct gaaccgtatg tagcgattga agtgaattat acggagggct 1650721 tcagcggaag caacctgtta gtcgtggaac aaagtgacgc ggcgatcatt gcggacttaa 1650781 tgatcggggg agacggaaaa ggtgcggacc cttcactggg tgaaatccat ttaagtgcgg 1650841 ttcaagaagc aatgaaccaa atgatgggat cggctgccac atcaatgtct actgtattca 1650901 gtaaaaaaat tgatatttca cctcctcggg ttgaattgct ggatgttact gaagaaaagg 1650961 gtacagaccg tattcctgat gatgaaatgc tggtgaaagt ttctttcaac ttaaaggtgg 1651021 gagaattaat agactccagc attatgcaac tttacccatt gacatttgcg aaagatttaa 1651081 tttcaagcct tatgaactca gaaagtgcag aggaagaaga aacggtgcag cctgaagtta 1651141 catacgaaca gccgaaagag cctgtgacgc cagagccgcg tattgaaccg aagcaacagc 1651201 agcagccgcc aaaaaggcag ggaacagcaa aaaaagcagc gccagttcag gtttcaccgg 1651261 tggaattttc cgcgtttgat ccaaacgaag ctgtacaagc ccctattcat aatctggata 1651321 tgcttttgga tatcccgctt tcgattactg ttgagcttgg cagaacgaag agaagcgtaa 1651381 aagagatttt agagctttct gccggaagta ttatcgagct tgataaatta gccggtgagc 1651441 ctgtagatat tttagttaat cagcgtatcg ttgccaaagg cgaggtcgtt gtcattgaag 1651501 aaaacttcgg agtgagagtc actgacattt taagccaggc agagcgcatt aataatttaa 1651561 aataacgaaa cacaaggaga gagatagatt atggcacata gaattttaat tgtagatgac 1651621 gcagcattta tgcgaatgat gattaaagat attttggtta aaaatggttt tgaagttgtg 1651681 gcggaagctg aaaatggagc acaagcggta gagaaatata aagagcattc acctgacctt 1651741 gttactatgg atatcacgat gccagaaatg gatggtatta cagcattaaa agaaattaaa 1651801 caaattgatg cgcaggcaag aatcatcatg tgttctgcta tgggacagca atcaatggtt 1651861 attgatgcca ttcaggccgg cgctaaggat ttcattgtga aacctttcca ggctgaccgt 1651921 gtgcttgaag caatcaacaa aacattaaat taaagggtgt acgactgttg aaaaagagtc 1651981 aatattttat tgtttttatt tgttttttcg ttttattcag tgtacatccg attgctgctg 1652041 ccgcggcaga ctctgataat tcaactgtaa acgaatggtt tcaaaagaaa gatgaaaaaa 1652101 ctgcagatca atcagagcaa aagaaagaaa aaacaacaaa aactgctgat gagacggagg 1652161 gagcggctgc tccttctgtc tcagcttttg attttgtaaa gatgattttc gctttactgt 1652221 ttgttatcgt gctgatttac gggctggtta agctcatgaa caaaagaaat cggctcctaa 1652281 agccttttca atatgttgaa aatattggcg gcacatcggt cggtcagaac agatccatac 1652341 aattgatcaa ggtcgggaaa agtgtgctcg tcgtcggtgt aggagagacg atccagctgc 1652401 tgaaagaaat tgaggatgaa aaagagattg aagtcattct cagtcagcat gaagaggcaa 1652461 tgtcaagcaa aatagagtgg caaaagtttg tgaagccgct taagagttct gaacatcagc 1652521 cgcagcaaaa actgccttca ttttcaaaag cattaaaaga gcaacttgaa gagttaaaac 1652581 aaaaccgttc tgaaggaaag aagaaaggcc cacgtcatca tgaatgagtt tataaatatt 1652641 ttcagttcaa gcgatccgga aaacgtaagt tcgactgtta aattactatt attgttaact 1652701 gtattttcag tggcgcctgg aatattgatt cttatgactt gttttactcg catcgtcatt 1652761 gttctgtcat ttgtcagaac ttcacttgcg acgcaatcta tgcccccaaa ccaggttcta 1652821 atcgggcttg cgctgttttt aacatttttt attatggctc ctactttttc agaaattaat 1652881 aaagaagcgc tgaccccatt aatggacaac aaaatcagct tggatgaagc gtatacgaaa 1652941 gctgaggaac cgattaaaga atttatgagt aaacacacaa ggcagaagga tctggcgctg 1653001 tttatgaatt acgcgaaaat ggataaacct gaatcattaa aggatattcc gttaacaaca 1653061 atggttccgg cttttgccat atcggagctt aaaacagcat ttcaaatagg ttttatgatt 1653121 tttatccctt ttttaattat agatatggta gtggcgagcg tcttgatgtc aatgggaatg 1653181 atgatgctgc ctccagttat gatttctctg ccctttaaaa tattactttt tgttttggta 1653241 gacggctggt atttaattgt gaaatctttg cttcagagct tttagggtag gtgctaaacg 1653301 tgagttcaga atttgtaatt tctatggcgg aaaaagccgt atacgtaacg ctgatgatca 1653361 gcgggccatt attggctatt gctttactgg tcggtttaat tgtcagcata tttcaggcga 1653421 caactcaaat ccaggaacag actttggcgt ttattccgaa aatcgtggcg gttctcctgg 1653481 ctctcatttt ttttggtccg tggatgctgt cgacgattct ttcatttaca acagagctgt 1653541 tttctaattt aaatcgtttt gcagggtaat gtagagatga attcaattat tgacttattt 1653601 cctgcttttt tattggtttt tattagaatc tctgcttttt ttgtaacgat tccgctattt 1653661 ggacatcgaa atgtgccagc tgttcatcgc ataggttttg ctttttttct tgcggtcatt 1653721 tgtttcagca ccattgataa accgccctct ttggagatag atgagcacta tatgcttttg 1653781 gcgtttaaag aagctttggt cggcctatgt ctgggtttaa ttgcttatat gatgattgcc 1653841 gcagtgcaga ttgccggctc gtttattgat tttcaaatgg gattttcaat agcaaacgtt 1653901 attgatccgc aaaccggtgc acaaagtccg ttgattggcc agtttatcta tacgatggca 1653961 cttttgttta tgctgagtgt caatgcccac catttgttgc tggatggtat ttactacagc 1654021 tttcagtata tttcagttga tcaggcattt ccgaatttcg gcgatgaaaa gtttgcctat 1654081 tttattgcga aaagctttaa tgcaatgttt attatcgctt ttcaaatgtc agcgccggtt 1654141 gtggccagtt tgtttctagt tgatttagca ttaggtatcg tggctcgaac tgttccgcag 1654201 ttaaatgtat ttgtggtcgg tctgccttta aagatcgctg tcagtttcat tatgctcatt 1654261 gtatgtatgt ccgttatctt cgtcgttgtc cggaatgttt tcagtttaac gattgaaacg 1654321 atgcggaatc ttttagcatt ggtcggtgtt tcttaatgaa gcttagagtt gacctgcagt 1654381 tttttgcggg agagaagaca gaaaaagcca ctccgaaaaa acggaaggat acgcgaaaaa 1654441 aagggcaggt agccaaaagc tcggatgtca ataccgccgt ttctttactg gtaatattcc 1654501 tttcgcttat tgcaattggt ccgtatatga gagacaggct gctgtcattc atagaaacat 1654561 tttataccga atcgctcaca atgaagctct cagaatcaaa tgtgcataca ttgtttgtca 1654621 gcttattaaa ggatatgggc atgatactcg caccgatctt gcttgttgct cttgttgcag 1654681 gagtcgtaag caactatatg caggttgggt tcttgttttc tgctgaagtg atacagccta 1654741 agcttgaaaa actggatccg atcaaaggct ttaaacgaat atacagtatg agggcgattg 1654801 tagagctgat taaatcaatt ttgaaaatcg tagtcgtcgg ttttgcggct tttgctgtgc 1654861 tttggctgca ttatggagaa attctccggc ttcctctcct gacacccgaa gaggcacttt 1654921 ctttcgtttc aaaactcact ttgtggatgg gactaagcgg tgcaggtgca ttgttgattc 1654981 ttgctggtct cgactattta tatcagagat ttgactatga gaaaaatatc aaaatgtcaa 1655041 aacaagatat aaaagatgag tacaaaaaat ctgaaggaga cccgattatc aagtctaaaa 1655101 ttaaacaaag acagcgggaa atggcgatga ggcggatgat gcaggaagtt ccaaaagcag 1655161 atgtcattat cacaaacccg actcactatg cgattgcttt gaaatatgat gaagaaaaaa 1655221 tggacgcacc ttatattgtt gcaaaaggcg tcgaccacct tgcgttaaaa atcaggaaaa 1655281 ttgctaaaga gcatgatgtc atgatggtag aaaacagacc gcttgcccgt gcgttatatg 1655341 atcaagtgga aattgaccag gcagtgccgg aagaattttt taaagtttta gcagaaattc 1655401 tggcttacgt atataaaaca aaacaaaaag tatattgaat ttttcgattt aaaaggagag 1655461 aaaaaacagc atgtcaacaa gagatttatc cgttttaata agtgttgtcc tcattgtggc 1655521 gatgctggtg attccatttc ctccatggct gttaagtatt ttgatcatta ttaatatttc 1655581 tcttgcgttg atcgtgcttc tcaccacaat gaatatgcag gaagcgcttc agttttcgat 1655641 ttttccgtca ctgttgctgc ttttgaccct atttcgtttg ggcttgaacg tctcaactac 1655701 ccgttcaatt ctttcacacg gtgagggagg taaagtcgtc gagactttcg gaaatttcgt 1655761 tgtcggcgga aatgtattag ttggactcgt tgtatttatc atccttatta ttattcagtt 1655821 tatcgtcatt acaaaaggtg ctgaacgtgt ttccgaggtt gcagcaaggt ttacgctgga 1655881 cgcaatgccg gggaagcaga tgagtattga tgctgattta aacgcaggga tgattaccga 1655941 acaggaagcg aagcatcgcc gcgaaaaagt ggcaagagaa gcagactttt atggagcaat 1656001 ggacggtgcc agtaaatttg taaaaggtga cgccattgcc ggaatcatca ttgtgatgat 1656061 caatattatt ttcggaatcg tgatcggaat gcttcagcag ggcatgtcca ttcaagaagc 1656121 tgcttcacac tttacgatgc tgactgtagg ggatggaatt gtttcgcaaa tcccggcact 1656181 gttaatttct acggctacgg gtattgtggt cacaagagct gcatctgaag gaaacttagg 1656241 gcatgacatt acaggccagc tgtttgcgta tccaaagctt ttatacgtcg cagcagctac 1656301 gatcatgctt ttaggtattt tcactccgat cggcatcctt ctgacggggc cgcttgcggg 1656361 attgcttgct tttggcgcat atacactatc taaatcaggt aaggaaaaag aagaagtgga 1656421 tgagattctt gaggaagagg ctgaggtgga cgagcttaaa agccctgaaa gtgttgttca 1656481 gcttctgcat atagatccga tagaatttga gtttggatat ggcctgatac cgcttgctga 1656541 tgccaatcaa ggcggtgatt tattagaccg aattgttatg atacgccgtc agttggcttt 1656601 ggaactcggg cttgtcattc ctgtcgtgcg aatcagagat aatatagcgt tgcagcctaa 1656661 tgaataccga ttgaaaatta aaggaaacga agtagcaaaa ggcgagctgt tgcttgatca 1656721 ttatttagcg atgtcgccta ctcctgagga cgatctcatt gaagggattg aaacagtgga 1656781 gccttcattc ggactgccgg ctaaatggat tagcgaagcg gtaaaggatg aagccgacat 1656841 gcttggttat acagtagttg atcctgcatc agtcgtttca acgcatatta cggagaaaat 1656901 taagcagcat gcccacgaat tgatcggaag gcaggagaca aaacagctga tcgatcactt 1656961 gaaagaatcg tatccagtcc tggttgaaga ggttacgccg aatccattgt ctgtcggtga 1657021 tattcagaaa gtgcttgcta agcttttaaa agaaaaagtt tcaattcgaa acttagtaac 1657081 gatttttgaa acacttgctg actatgggaa attaacaaca gattctgatc tcttgacaga 1657141 gtatacaaga caagcgcttg ctaaacaaat tacagcccag tttgccaaag aaaatgaagt 1657201 gttgaaggtt gttacttgtt ccggccgtgt agaaaaagca atagcagacg gtgtgcagca 1657261 gacggaacac gggaactatt tatcacttga accagatatt tcagaaagta tagtgcgctc 1657321 tgtcgccaaa gaagctgaac agctctcatt acgtcaggaa accgcgattc ttctttgctc 1657381 gccgcctgtc agaatgtatg tgaagcagct actggaacgg tacttccctg atcttccggt 1657441 actctcttat aacgaacttg aggcgaatgt tgaggtacaa agcattggag tggtggatat 1657501 ttaatgaaaa taaaaaaatt tactgctgct tcaatgcaag aagcggcact tctcatcaga 1657561 aaagagttag gtaatgaagc ggtcatatta aattcgaaaa aaattaaaaa gcgaaaatgg 1657621 tttggcctcg tcaacaagcc tgctgttgaa gtaatcgccg tattggatca ggactttctt 1657681 gagaaaaaaa cgcctcagaa ggcagctgaa ccgaaacaaa cattaaaaac tccggtcagc 1657741 agtccaaaaa tagaggagag aacatatccc cctcaaattc cggcgcaaca ggagctaggt 1657801 gatttttcag catatcaatc tgtacttcct gagccgctgc gaaaagcaga aaagcttttg 1657861 caagaaacag ggatcaaaga gtctacgaaa acgaacactc tgaaaaaatt gcttcgcttc 1657921 tctgttgaag caggcggctt gactgaagaa aatgttgtcg gcaaacttca ggaaatacta 1657981 tgcgatatgc tgccctcagc agacaagtgg caggagccaa ttcattcaaa atatatcgtt 1658041 ctctttggtt caacaggggc tggtaaaaca actacactgg ctaaactcgc agccatatct 1658101 atgcttgaaa aacataaaaa aatcgctttt attacaacag atacgtatcg tattgcagct 1658161 gttgaacagt tgaaaacata cgctgaactg ctgcaggctc ctctggaagt ttgctataca 1658221 aaagaagaat ttcagcaggc gaaggagcta ttttctgagt atgatcatgt gtttgttgat 1658281 acagctggaa gaaacttcaa agacccgcaa tacattgatg aactgaaaga aacgattcct 1658341 tttgagagca gcattcagtc atttcttgtt ttatccgcga ctgcaaaata tgaagatatg 1658401 aagcatattg tcaaacggtt ttcatccgtc cctgtcaatc agtatatttt tacgaaaata 1658461 gatgaaacga cttccttagg ttctgtattt aatatactgg cagaatcaaa aataggtgtc 1658521 gggtttatga ctaacggcca gaatgtgcct gaggatatac agactgtatc tccacttggt 1658581 tttgtgagga tgctgtgcag atgaacagat atgaccaagc agcaacttta cgggcgaaaa 1658641 tggaaaaacg tgagcgcgtt ctgccaatgg tttattcaca aaaagcgaag acacttgctg 1658701 tcatcagcgg caagggcggt gtcggaaaat ccaatattac cttaaatatg gcacttgcgc 1658761 tgcaggataa aggtaagaag gtgctgctca tcgaccttga tatcgggatg gggaacattg 1658821 atatattaat aggaaattca tcgtctgcca cgataatcga tgttttaacc gatcgtaagc 1658881 ctttgctgca gtcattatcc gttggcccaa agggtttgcg gtatatatca gggggaaccg 1658941 gtcttgatgt gatgtttcag ctcgatcaga gaaaatggac gttttttgcc aatgaacttt 1659001 ctcatgcatt aagccagttc gattatgtgc tgtttgacat gggagcaggc ttatcaaaag 1659061 atcaactgcc ttttatttta tcagcagaag atattttgat tattacaact cccgagccga 1659121 cggccattat ggacgcatac agcgctgtca agcacttggt tttgacagaa aataagcttt 1659181 caatgaaggt ggctgtcaat cggtgccgtg accaaaagga agggcttgac gcttttgccc 1659241 gcctctcccg tacaattcat atgtttttgg atgttcaggt tcagtttgcc ggttccgttt 1659301 ctgacgatgt gatcgtgagc aaagcggttg tcgaacaggt tccttttttc ataaaaagcc 1659361 ctcaggcaaa agccagccgg tcagtccgta ttttagcgga cgccttgttt gaaagagaag 1659421 aaacgagaca caaagaagac aaacagacat ttattgagaa attatcttct tttttaatga 1659481 ggagggctta atttgattcg tgtgcttgta gttgatgatt cagcttttat gagaaaaatg 1659541 ataagtgatt ttctgaccga agaaaagcag atagaagtaa tcggaactgc gagaaacgga 1659601 gaagaagcgc ttaagaagat tgaattatta aaaccggatg ttattactct tgatgttgaa 1659661 atgccggtca tgaatgggac agatacgctc cgcaaaatta ttgagattta taacttgccg 1659721 gtcattatgg tgtctagcca gaccgagaaa ggtaaagaat gcacaattaa ttgtttggag 1659781 atcggtgcct ttgactttat cacaaagcca tcaggctcaa tatctctgga tctatacaaa 1659841 attaaagaac aactagttga gcgtgtcgtc gcggcaggac tttccggcaa gcggaaacgt 1659901 cctgtttccc agacagttcg gcccgaacct attgtgcgtg ctgtcgttaa gcctgaatta 1659961 agcaaaccga aacctggcac gggcagacaa attgtgtgta tcggcacatc aacaggcggt 1660021 ccacgggcgt tacaaaaggt gataccgaag ctccctaagg atttgaacgc accagtggtt 1660081 gtcgttcagc acatgcctga agggtttact gcttctttgg ctgatcggct gaatcattta 1660141 tctgacattc aggtaaaaga agcaaaagat ggtgaagcag ctcttaacgg ctgtgtttac 1660201 atagcaccgg gcggaaaaaa catatccgtt attaaaaaca gcgaaggact ccaggttgtg 1660261 cttgataacc atgacacacc aagccgtcat aaaccatctg ctgattattt attccgttct 1660321 gtcgggaaac tgacagatta tgaaaaagta gcggttatca tgaccggaat gggcagtgac 1660381 ggcactgctg gactaaagga catgctaaca gccggcaatg tgaaagccat tgcggagtct 1660441 gaagaatctt gtgtcgtata cgggatgcca aaagctgctg ttaaagcggg tctcattcat 1660501 gagattaaac atgtggaaga tatcgcagca tccatcacaa gctgtgtgaa aaaagagagg 1660561 gtgtgattca aatggatatg aatcagtatt tagatgtctt tattgatgag agtaaagaac 1660621 atttacaaac atgtaatgaa aagcttcttc ttttagagaa agacccgact gatcttcagc 1660681 tcgtacatga tatattcagg gctgcccata cattaaaagg aatgagcgca acgatgggct 1660741 acacggattt agcacatctt acccatctgc ttgaaaacgt gctggatgca atccgaaacg 1660801 gagacatgga agtcacctca gactggctgg atattttgtt tgaagctctg gatcacctgg 1660861 aaacaatggt tcagtctatt attgatggcg gggatggtaa aagagatatc tcagaagtga 1660921 gtgccaagct tgatgtgaat ggtgcgcacg ctgaatccgc tgcctccgct gaacctgcag 1660981 aagcacagag ttcagcatct gattgggaat atgatgaatt tgaacgcaca gttatacaag 1661041 aagcggagga gcaaggcttc aaacgatatg aaatcaagat ttctctgaac gaaaactgta 1661101 tgttaaaagc agttcgtgtc tatatggtgt ttgaaaaact aaatgaagtc ggagaagtag 1661161 ccaaaacaat tccaagtgct gaagtgcttg aaacagaaga ttttggaact gactttcaag 1661221 tttgtttctt aacacatcaa tcagcggaag acattgaaca attaatcaat ggcgtgtcgg 1661281 aaattgagca tgttgaagtc attcaagggg ctcctttaac atcagctgaa aagcctgaag 1661341 aatctaagca agaagattca ccagcagcag ctgtacctgc gaagcaggag aaacaaaaac 1661401 agcctgctaa aaacgatgaa caggcgaagc attcagccgg cggatctaaa acaattcgtg 1661461 tcaacattga caggcttgat tctttaatga acttatttga agagcttgtc attgaccgcg 1661521 ggcgtctcga gcagattgcg aaagagcttg agcataatga actgactgaa acggttgaac 1661581 gaatgacgag aatttccgga gatttgcaat cgattattct gaatatgaga atggtcccgg 1661641 ttgaaactgt ttttaacaga ttcccgagaa tgattcgcca gcttcagaaa gagctgaata 1661701 aaaaaattga actctcgatc atcggtgcgg aaactgaact ggatcgtaca gtaattgatg 1661761 aaatcggaga tccactcgtt cacttgatca gaaacagtat tgaccatggt atcgaggcgc 1661821 cggaaacacg tttgcaaaag ggaaaaccgg aatcaggaaa agttgtgctt aaagcttatc 1661881 acagcggcaa ccatgtcttt atcgaagtag aggatgacgg cgcaggcctt aatcgaaaaa 1661941 aaattctgga aaaagcgctt gagcgcgggg tcataacgga aaaagaagct gaaaccttag 1662001 aagacaacca aatttacgaa ttgatttttg ctccggggtt ctcaactgct gaccaaattt 1662061 ctgatatttc cggccgcggt gtaggacttg acgttgtaaa aaacaaactg gagtctcttg 1662121 gcggttcagt cagtgtgaaa tcagccgagg gtcaaggctc tctattcagc atccagctgc 1662181 cgcttacctt gtctattatt tcagttctgc tgattaagtt ggaagaagag acatttgcca 1662241 ttccgatttc ttcaatcatt gagacagcag ttattgacag aaaagacatt ttgcaaacgc 1662301 atgaccgtga agtgattgac tttagagggc atattgtccc tgtcgtttat ttaaaagaag 1662361 agtttaaaat agaagataca agaaaagatg cggaacagct ccatatcatt gtcgtgaaaa 1662421 aaggcgacaa acctactgca tttgtggtgg actcctttat tggccagcag gaagttgtgc 1662481 tgaaatcact cggagattat ttaacaaacg tctttgcaat ttccggagct actattttag 1662541 gagacggaga agtagcgctc attattgatt gtaatgcact gattatttaa ccattcgagg 1662601 aggtgtctca catgactgca gaaattaaaa caggcgaaaa aatgatagtc tttatggtaa 1662661 atggcaaaga atatgccatt tccgtcactc aggtgaaatc aattgaaaaa tggcaaaagc 1662721 caacgagggt acctggcgtc gaaccatata tttgcggggt aatcaattta cgcggggtgg 1662781 tgactccggt tattgattta agaaaacgcc tgaatttgcc agagtatgaa attacagatg 1662841 aaacacgaat tatcattatt gcttatcgtg atattgaagt cggctggatt gtggatgaag 1662901 cgaatgatgt gattaccgta cacgaaagtg aaatagaatc tgctccagaa ggcgttcaga 1662961 aagatacgga tgtgtcgatc gaacagattg tgaaacaaga gaacagactc ttaaatatta 1663021 ttgatgcgaa cgcggttttg gataaagaat catctcagtc cgctgtgccc gatcaagctt 1663081 aatcttaaag gggttatgac atgagtattt ttaatggaat caaagaagag cagatggaca 1663141 ttttgcggga agtcggcaat ataggcgccg gccactccgc ctctgcaatg gcccagctgt 1663201 taaatagaaa gatagatatg gaagtcccat ttgcaaagct gctgtctttt gatgagcttg 1663261 ttgatttttt cggcggcgcc gatgtcccgg ttgccagcat ctttttaaga atggaaggcg 1663321 atttaacggg ttcaatgttc tttataatgc ctttttttca ggcggagcag tttatcagag 1663381 agctgattgg aaaccccgat tttgacatag aggacttagg tgaagaccac atgagctcat 1663441 ccgctttgca tgaactgggc aatattttag cggggtcata tttaacagct ttggcggatt 1663501 tgacgaaact ccagctctat ccaagtgttc ctgaagtctc attggacatg ttcggagctg 1663561 tgatcagcga agggctgatg gagctcagtc aggttggaga acacgccatt gttgtcgaca 1663621 cgtcaatttt tgaccaaagc catcagcagg agctgaaagc gcatatgttt atgctgccgg 1663681 actatgattc atttgaaaag ctctttgtcg ccttaggtgc atcattatga gtacaactga 1663741 ggctgttgtt ataaaggttg ggattgctga cgtgaagatc gcccgcttcc cggataccat 1663801 ccggacctct ggtttgggct catgtgtggg gctggtgctt tatgataaag aaaagcaaac 1663861 ggcgggtctt gttcatgtca tgcttccgga ttcgacgtta tcgaaaactg ccgagctcaa 1663921 ccgggctaag tacgctgaca ccgccgtaca gaccacgatt gatatgctga tagaagcggg 1663981 atgccggaaa tttgcattaa aagcaaagct ggccggcgga tcagagatgt ttaaatttaa 1664041 atcgacaaat gatttgatga agatcggacc gagaaatgta ttagcgataa aagaacagct 1664101 gtctttattt aatattccta ttattagtga agatacgggc ggctcaagcg gccggacgat 1664161 agaatttgaa ccgaagtcct gcatgctgca tattcgaact gttaaacaag gtgaaaaaac 1664221 gatttaatta aggtattagg gggataacaa tgcaatcctt gaattatgaa gatcaggtgc 1664281 tttggacgcg ctggaaagag tggaaagatc ctaaagccgg tgacgactta atgcgccgtt 1664341 acatgccgct tgtcacatat catgtaggca gaatttctgt cggactgccg aaatcagtgc 1664401 ataaagacga tcttatgagc cttggtatgc ttggtttata tgatgccctt gaaaaatttg 1664461 accccagccg ggacttaaaa tttgatacct acgcctcgtt tagaattcgc ggcgcaatca 1664521 tagacgggct tcgtaaagaa gattggctgc ccagaacctc gcgcgaaaaa acaaaaaagg 1664581 ttgaagcagc aattgaaaag cttgaacagc ggtatcttcg gaatgtatcg cccgcggaaa 1664641 ttgcagagga actcggaatg acggtacagg atgtcgtgtc aacaatgaat gaaggttttt 1664701 ttgcaaatct gctgtcaatt gatgaaaagc tccatgatca agatgacggg gaaaacattc 1664761 aagtcatgat cagagatgac aaaaatgttc cgcctgaaga aaagattatg aaggatgaac 1664821 tgattgcaca gcttgcggaa aaaattcacg aactctctga aaaagaacag ctggttgtca 1664881 gtttgttcta caaagaggag ttgacactga cagaaatcgg acaagtatta aatctttcta 1664941 cgtcccgcat atctcagatc cattcaaagg cattatttaa attaaagaat ctgctggaaa 1665001 aagtgataca ataatgaatt tcatggttag cgagtgaaaa acatgtcaac actattatgg 1665061 cttttaagct ttatgctcca cggcgttctt ctgtacgctg tcattatcct gtatacgagg 1665121 ctcgctgcag tgaaagaaac agaaaaacag caaaaacaga tacttgaaga gacggaaaac 1665181 accttggcgg catttctgct tgaattaaaa gaagaaaatg agaaactgat agaaaataaa 1665241 gcttcatctg caagtcaatc agatgaagaa tcccaaaagt caggccttca gacctctgaa 1665301 acatatcaag agcgggatcc agtccaagag gcagagaatc ttcctgaaca tattgaaggt 1665361 ctgattacag aggttgaccg tcgggaagag ctcgtaaaca gtgaggtcca atcatttgaa 1665421 gaccaggtca tagaattata tgaacaggga tattcggcaa gtcaaattgc ccagaaaatg 1665481 aagagcggaa agacagaaat cgagctattt ttaaaatttc gctccaaagg tgtaaaggat 1665541 tcttgattgt cggataaagc tgtgttatat tatgtcttgg tgttaaatac acacgcttaa 1665601 cgatttatgc agagggtgct gcaggcggca gttctgtaca aaaatgacct aagcggagga 1665661 aaaaaaccat tatattagga ggaaataaca tgtcagtcat ttctatgaag caattgcttg 1665721 aagctggtgt tcacttcggt caccaaacac gccgttggaa cccaaaaatg aagcgttaca 1665781 ttttcacgga gcgtaacgga atctacatca ttgaccttca aaaaacagtc aaaaaagtag 1665841 aggaagctta caacttcact aaaaatcttg ctgctgaagg cggaaaaatc cttttcgtcg 1665901 gaacaaaaaa acaagctcaa gattctgtta aagaagaagc tcaacgctct ggcatgtact 1665961 atgtcaacca acgctggttg ggcggtacat taacaaactt cgaaacaatc caaaaacgta 1666021 ttaaacgtct taaagacatt gaaaaaatgc aagaaaacgg tacgtttgat gtacttccta 1666081 aaaaagaagt cgttcaattg aaaaaagaat tagagcgtct tgaaaaattc ctaggcggaa 1666141 ttaaagatat gaaggatctt cctgatgcat tattcatcat cgatcctcgc aaagagcgca 1666201 tcgctgttgc ggaagctcgc aaattaaaca tccctatcat cggtatcgta gatactaact 1666261 gtgatccaga tgaaatcgat gttgttatcc cagcgaacga tgacgctatc cgcgctgtta 1666321 aacttctaac ttctaaaatg gcagatgcaa tcttagaagc gaagcaaggc gaagaagaag 1666381 cggaagttgc tgaagaaact gcaccagaaa cagaaacaac aactgcgtaa cctattcaaa 1666441 aggtgataag agggactgcc ttttatcacc ttttttcaag aaaaatgtgt aatatacata 1666501 ctcttgttta aacatataag gaggaataca aatggcaatt actgcacagc aagtaaaaga 1666561 actgcgtgaa aaaactggcg cgggcatgat ggattgtaaa aaagcgttaa ctgaaactga 1666621 cggagatatg gacaaagcaa ttgacctttt aagagaaaaa ggaattgcaa aagcagcgaa 1666681 aaaagctgac cgtatcgcag cagaaggttc tactcttatt aaaactgacg gcaacaaagg 1666741 cgttatccta gaagtaaact ctgaaactga tttcgttgcg aaaaacgaag gttttaaaga 1666801 gcttcttaac actttagctg accaccttct tgcaaacacg ccagctgatg ttgaagaagc 1666861 aatgggccaa aaaatggaaa atggctcaac tgttgaagag tacatcacaa gcgcagttgc 1666921 taaaatcggt gagaaaatca ctcttcgccg ctttacagtt cttacaaaag acgacagctc 1666981 tgcattcggt gcgtaccttc acatgggcgg ccgcatcggt gtattaactg ttctcaacgg 1667041 tacaactgat gaagaaactg cgaaagatat cgcaatgcac gttgctgcag ttaaccctcg 1667101 ttacatttct cgtgatcaag tatctgaaga agaaacaaat catgagcgtc aaatcttaac 1667161 tcagcaagcc ctccaagaag gcaaacctga aaacatcgta gcgaaaatgg ttgaaggccg 1667221 tctgaacaaa ttcttcgaag aaatttgtct attagaccaa gcgttcgtta aaaacccaga 1667281 tgaaaaagtg aaacaagtta ttgcagcgaa aaacgctact gttcaaactt ttgtccgcta 1667341 tgaagttgga gaaggcatcg aaaaacgtca agaaaacttt gctgaagaag taatgaacca 1667401 agtgaaaaaa taatggtgaa aagatttcgc ggctaagtcg cgtcttttca ggcagtatag 1667461 gggacacatt ttgtgttccc tatttttaaa actatattta caaacctttt tttctcttgc 1667521 ataatagaaa acggcaatgt ttacacttgg aggttatcat ggaaaaacca aaatacaaac 1667581 gtatcgtatt aaagcttagc ggggaagcat tggcaggaga acagggaaat ggaattaacc 1667641 cgactgtcat tcaatccatt gcaaagcaag tgaaggaaat cgctgagctt gaagtcgaag 1667701 tggctgttgt tgtaggcggc ggcaacttat ggcgcggaaa aacaggaagt gacctgggca 1667761 tggaccgcgc gactgctgac tatatgggaa tgctggcgac agtaatgaat tcgcttgctc 1667821 ttcaagacag cttggaaaca ctcggaatcc agtccagagt gcaaacatcc attgaaatga 1667881 gacaagttgc tgaaccgtac ataagaagaa aagcgatacg ccacttagag aaaaaacgtg 1667941 tcgttatttt cgctgcgggc acaggaaacc catatttctc aactgatacg acagctgcac 1668001 tgcgggctgc tgaaattgag gcagacgtta ttttaatggc taaaaataac gttgacggtg 1668061 tgtataatgc tgatcctaga aaagatgaat cagctgttaa gtatgaatca ctttcttatc 1668121 ttgacgttct taaagacggc ctggaagtca tggattcaac agcttcctct ttatgcatgg 1668181 acaatgacat tccgcttatc gtcttttcta ttatggaaga aggaaatatc aaacgtgccg 1668241 ttatcggtga atcaatcgga acgatcgtga gggggaaata acgtgtcaaa agaagtatta 1668301 actcaaacaa aagaaaaaat ggaaaaagca attgctgctt atcagcgcga attggctact 1668361 gtacgcgcag gccgtgcaaa tccatcatta ttagataaag taacggttga atattacgga 1668421 gcgcagacac ctttaaatca gttgtcttct attaacgtgc ctgaagctcg tatgctcgtt 1668481 atcacgccat acgataaaac agcaatcggt gatatcgaaa aagcgatttt aaaagctgat 1668541 ttaggtctta caccaacaag tgacggcaat atgattcgaa ttgcaattcc ggcactaaca 1668601 gaagagagac ggaaagaatt agtgaaagtt gtaaaaaaat atgctgaaga agcaaaagta 1668661 gctgttcgta acgttcgccg tgatgctaac gatgatctca aaaaacttga gaaaaacgga 1668721 gacattactg aggatgaact gcgtgcttcc actgaagacg ttcaaaaact gacagatgaa 1668781 tatgtgtcaa aaattgacag tgtcacaaaa gacaaagaaa aagaaatcat ggaagtttaa 1668841 tgaaaaacta tgtacaatag ataatagtga aaagaccctc tcatgtttac agggggtttt 1668901 tttgttaata ctgttgatta cattgattat cagcagggaa tgtaaccttt ttgggtgacg 1668961 gaggaatctc atgctcaaca tactcaaaaa ttggaagaat cagcaaactg cggcttccaa 1669021 cttagaacgt tatacaaaag aagacatact taagggagaa attcccgaac acatcgccat 1669081 tatcatggat ggaaatggcc gttgggctaa aaaacgctct cttcccagaa ttgcaggcca 1669141 ccatgaaggg atgaaggtgg taaaaaggac cacgaagctc gcaaacgaat taggtgtcaa 1669201 agtactgaca ttgtatgcat tttcaacaga aaactggaaa agaccgaaaa tggaggtcga 1669261 ttttttaatg aagcttccgg aagaattttt gaatacgtat cttccagagc ttgttgagga 1669321 aaatgtacag gttcggatca ttggggatga aacggctttg ccggcgcaca cattacgtgc 1669381 gattgaaaaa gctgtacagg acacggcgca aaacgacgga atgatcctta attttgctct 1669441 taactatgga ggccgtactg aaattgtcag tgctgcaaaa tcactcgcgg aaaaagtgaa 1669501 ggaaggctct ttgaatattg aagacattga tgaatcgctt ttttctactt atttgatgac 1669561 tgaatctttg caggatcctg aacttttaat tcgaacgagc ggcgagataa ggctgagtaa 1669621 ttttatgcta tggcaggttg cctacagtga atttgtcttt actgacgtct tgtggcctga 1669681 ctttaaagaa gatcacttct tgcaggcgtt aggagagttt cagcagagag gccggaggtt 1669741 tggcggaatt tagaggatgg tggacatgaa acaaagaatt ttgacaggtg ttctggcagc 1669801 aattgtattt ttatttttgg ttattgtcgg gaaattgccg ttcaccatat taatttatgc 1669861 tatgggcagt gtggcgcttt ttgaactttt acggatgaaa aagctgaagc tggtttcact 1669921 gccgggtttg atcggtcttt tattattgtg gatgttctta ttaccaagcc agtattcgtt 1669981 ttttgaagcg gacgggattt ccaaaatgga aatcgcttta tttgcggtac tgctattgct 1670041 gacttacaca gtgttggtca agaacacctt tacttttgat gaagtcgggt ttattacgct 1670101 tgcagcaatt tacatcggaa tgtgttttca ttattttatc gaaatcagaa atcttgacca 1670161 atacggatta acatacattt tttatgcgtg tgttgtcatt tggtccaccg attccggtgc 1670221 ctattttgtc ggtaaatcgc ttgggaagcg gaaactgtgg cctgaaatca gtccgaataa 1670281 aacagtggaa gggtttgcag gcggaattgt catcgcactt gtattggcga cgatttttca 1670341 gcttgttgca caacttccga tcccgtatat ctatctgctg ttgatcacgc tgtttttgtc 1670401 tgtttttgga caactgggag atttagtgga atccgccttg aaaagacatt acgatgtaaa 1670461 ggattctggg aatattcttc ccgggcatgg cggtatatta gaccgttttg acagtttctt 1670521 gtttgtcatg cctttcttgt actttctgct tgcccttttt tcataaaaaa gtctaatatg 1670581 aatatgagac tgatcatgca gcaataagaa taggagtagt ggcaactttg aaaaatattt 1670641 gtcttttagg agcaacagga tcaatcggcg aacagactct tgatgtactg cgtgcacatc 1670701 aagaccaatt tcagctggta tctatgtcgt ttggcagaaa tattgataag gccgttccaa 1670761 tgattgaggt ctttcagccg aagtttgtct ctgtcggtga tctggataca tatcataaat 1670821 taaaacaaat gtctttttct tttgaatgcc aaatcgggct gggagaagaa ggactgatag 1670881 aagcagcagt gatggaggag gttgacattg ttgtcaacgc tttgcttgga agcgtcggtc 1670941 ttatcccgac attaaaggca attgaacaga aaaaaacaat tgcgcttgca aataaggaaa 1671001 ctcttgtcac tgcagggcat atagtaaaag aacatgctaa gaaatatgat gttccgctgc 1671061 tgcctgttga cagtgagcat tcagccattt ttcaagctct tcaaggcgaa caggctaaaa 1671121 acattgaacg cctcatcatt acggcatccg gcggaagttt tcgggacaag acgcgggagg 1671181 agctcgaatc agtaacggtt gaagatgcat taaaacatcc aaactggtca atgggtgcaa 1671241 aaattacaat tgattcggct acaatgatga ataagggatt agaggtgatc gaggcacact 1671301 ggcttttcga tataccttat gaacaaattg atgtggtttt acataaggag agcatcatcc 1671361 attcaatggt tgagttccat gataaaagtg tgatcgcaca gctcggaact ccggatatga 1671421 gagtccccat tcaatatgcg ctcacttatc ctgaccgatt gccattacca gatgcgaaaa 1671481 ggcttgaatt atgggaaatc ggcagccttc attttgagaa agctgatttt gacaggttcc 1671541 gatgcttaca atttgctttt gaatcaggta aaataggagg aacaatgccg acagtgctaa 1671601 atgcggcaaa cgaagtagct gtcgctgcct ttttagctgg caagataccg tttttggcta 1671661 ttgaagactg tatcgaaaag gcactaaccc gccatcaatt actgaaaaaa ccgagcctgg 1671721 cggacattca agaagtggac aaagataccc ggggatacgt caattcaata ctcacataag 1671781 gtggtatgtt cgtgaataca gttatagcgt ttatcattat tttcggaacg ctcgttttct 1671841 tccatgaact gggccattta ttgctagccc aaagagcggg aattctctgc cgtgaatttg 1671901 cgatcggctt cggtccaaag attttttctt tcaaaaaaaa tgaaacagtt tatacgatca 1671961 ggctgcttcc ggtcggcgga tttgttcgta tggccggcga agatccggaa atgattgagg 1672021 tgaaacccgg atacacggtc gggcttctgt ttaataagga agatcaagtt gagaaagtca 1672081 tcatcaatca aaaggaaaaa tatccggatg ctttagtcat tgaagtggaa acagcggatc 1672141 tagagcatga catgaagatc accggttatg aacaggggaa agaggacgaa ctttccagct 1672201 ttactgtcag cgaaacatcc ttttttattg tagacggaga agaagtgcag attgcgccgt 1672261 ataatcgcca atttggttcc aaacctgtat ggcagcggat taaagcaatt gctgcagggc 1672321 cgattatgaa ctttatttta gcttacgtca ttttagtgat gcttgggctg attcaaggcg 1672381 taccgtcaaa tgaacctatg ctcgggcagc tgacagacaa tggacgggcg gctgaagcag 1672441 ggctaaaaga aggggattat atccaaagca ttaacggaga gaaaatgagg tcttggactg 1672501 acattgtctc cgctgtaaaa gaaaacccgg agaaagaaat ggacgttgca gtaaaaagag 1672561 ataacaaaac gcttcatatt tcggtgactc cggaagctgt taaagatgag aacaaaaaaa 1672621 caatcggacg tttcggttcc tatgcgccga ctgaaaaagg cgtactctca gcggttgctt 1672681 acggcgcgac atcaacagtt gatgtcacca aagccatttt aaccaatctg agcaaattag 1672741 taacaggcca atttaaactc gatatgctgt caggtcctgt cggcatatat gacatgacag 1672801 accaagtggc gaaaacaggg atcgtgaact tatttcagtt tgcggcgttt ttaagcatta 1672861 accttgggat tgtcaacctg cttccgattc cggcacttga cggaggaaga ctgttgtttc 1672921 tatttattga agcgattcgg ggcaaaccga ttaacaggga aaaagaagca tttgttgtgt 1672981 ttatcggagt agctttctta atgcttctta tgctggttgt cacatggaac gatatccagc 1673041 ggctgttttt gtaaacgaaa agtaaatcaa tcagaggtgc gaagaaatga gacaaagctt 1673101 gacgcttatt cctacgctcc gtgaagttcc agctgatgcc gaagcaaaaa gtcatcagct 1673161 tcttctgaga gcaggattta tcagacagaa tacgagcggg gtatacagct atatgcctct 1673221 tgcgtataag gtgattcaaa acattcagca gattgttcga gaggaaatgg agaaaattga 1673281 tgccgtagaa atgctcatgc ccgcattgca gcaggcagag acatggcagg aatcaggcag 1673341 atggtatacg tatggtcccg aactgatgag actaaaagac cgtcatggcc gtgaatttgc 1673401 tttaggggca acgcatgaag aggttatcac ttcgcttgtt cgcgatgagg ttaaatctta 1673461 taagcgtctc cctctgactc tttatcaaat tcagtctaag ttcagagatg aaaaacgtcc 1673521 tcgcttcggt ttgttaagag gccgcgaatt tattatgaag gatgcgtact ctttccatgc 1673581 atctgcagag agcctggatg aaacgtatca aaaaatgtac gaggcctatt ctaatatttt 1673641 tgcccgctgc ggcattaatg taagacctgt tatcgctgat tcaggcgcaa tgggaggaaa 1673701 ggatacgcac gaatttatgg cactttctgc gatcggagag gatacgattg cgtattctga 1673761 tgaatcacag tacgcggcta atatcgagat ggctgaagtt cttcaccagg aagttccttc 1673821 agatgaagag cctaaagctc tagagaaggt tcatacgcct aacgtgaaaa caatcgaaga 1673881 actgactgcg ttcttacagg tttcggctga agcgtgcatt aagtcagtat tgtttaaagc 1673941 tgatgaccgt tttgtcttag tgcttgtaag aggggatcat gaagttaacg atattaaagt 1674001 gaaaaacttg cttcatgcag aagttgtaga gcttgctaca catgaagagg tcattcagca 1674061 gctcggaaca gagccaggct ttgtaggccc tgtcggtatt catcaggatg tggaagtata 1674121 tgccgatcaa gctgtgaaag caatggttaa tgctgttgcc ggggcaaatg aaggagatca 1674181 tcattataaa aatgtcaatg tgaatcgtga cgcgcaaatt aaagaatttg ctgatcttcg 1674241 ttttattaaa gaaggtgatc cttcaccaga cggcaaggga acgatccgtt ttgctgaggg 1674301 aatcgaagtc ggacaagtct ttaagctcgg aacacgctat tcagaagcga tgaatgcgac 1674361 atatttagat gaaaacggac gcgcgcagcc aatgctgatg ggctgttacg gaatcggtgt 1674421 gtcaagaacg ctttctgcta ttgctgaaca gcatcacgac gaaaaaggct taatatggcc 1674481 aaaaagcgtt gcgccgtacg atcttcatat tcttgctttg aacatgaaaa acgatgggca 1674541 aagagagctt gctgaaaagc tgtatgccga tttaaaagcg gaaggctatg aagtgctcta 1674601 tgatgaccgt gctgagcgtg ccggcgtaaa attcgctgat tcagatttaa tcggccttcc 1674661 aatccgcatc actgtcggaa aacgagctga cgaaggaatc gtcgaagtga aaattcgtca 1674721 aactggtgag tcaactgaga tttcagtaga cgaattatct gcgtttatca gcaagcagta 1674781 atcaccataa cgatttatca aaaaacatgt taaaatagaa ataatagaag gtacctcatt 1674841 gcctgaggta ccttcactta tgatgttttt agggagggat actgtcttaa tggaacagtt 1674901 atcagtaaac agaaggcagt ttcaaattct tctgcagcag attaatatga cagatgatac 1674961 cttcatgaca tactttgaac atggcgagat taaaaagctg acaattcaca aagcttctaa 1675021 gtcttggcat tttcattttc aatttaaatc tttgctgcct tttcaaatat atgacacatt 1675081 aacaacgagg ctgacgcaat cgtttgccca catagcaaaa gtgacatctt caattgaagt 1675141 tcaggatgcc gaggtcagtg aaagtatcgt tcaagactac tggtcacgct gcattgaaga 1675201 actgcagggc atttcgccgc cgattatcag tcttttaaac cagcaaaaac cgaagctgaa 1675261 gggcaataaa ctgattgtca aaaccaaaac agatacagaa gcggctgcgc taaagaacaa 1675321 atacagttcc atgattcaag cagaataccg tcaatttggc tttccggatc ttcagcttga 1675381 tgctgaaata tttgtatccg agcaagaagt tcaaaagttt cgggagcaaa agcttgcgga 1675441 agaccaagag cgggctatgc aggccttgat tgaaatggag aagaaagata aagaaagtga 1675501 tgaagaccaa gcaccatctg gtcctcttgt tatcggttat caaattaaag ataacgagga 1675561 aatccgaaca cttgacagca tcatggacga agaacggaga attacggtcc aaggttatgt 1675621 gtttgatgtg gagacgcgcg agctgaagag cgggcgcacg ctgtgtatct tcaaaattac 1675681 agactataca aatagtattt tgatcaaaat gtttgcacgt gaaaaagaag atgcggcgct 1675741 gatgaagtct ctgaaaaaag gaatgtgggt aaaagcacgc ggaagcattc aaaatgatac 1675801 atttgtcaga gaccttgtca tgatcgcaaa tgacgtaaac gaaataaaag caaaaacccg 1675861 tgaagattca gcacctgaag gagaaaaaag agtggaattg catcttcatt ccccaatgag 1675921 ccaaatggat gctgttacgg gtatcggaaa gcttgtcgaa caggcgaaaa aatgggggca 1675981 tgaggccatc gctttgaccg accatgctgt cgttcaatcc ttccctgatg cgtattctgc 1676041 ggccaaaaag catggaatta aaatgattta cgggatggaa gcgaatctcg tggatgatgg 1676101 cgtgccaatt gcttataatg ccgcacatcg tctgctcgaa gaagaaacat atgttgtttt 1676161 tgacgttgag acgacaggat tgtctgctgt atacgatacc attattgagc tggctgcagt 1676221 aaaagtaaaa ggcggagaaa ttattgataa atttgaggcg tttgcgaacc cgcatcgtcc 1676281 gctttccgcc acaatcatag agctgacagg gatcacagat gatatgctac aagacgctcc 1676341 ggatgtcgta gatgtaataa gagatttcag agaatggatt ggcgatgata ttcttgtcgc 1676401 tcataatgca agctttgata tgggattctt aaatgtagcc tataaaaaac ttcttgaagt 1676461 cgaaaaagct aaaaacccag tcattgatac gcttgaactt ggacgttttc tctatccgga 1676521 atttaagaac caccggttga acacactttg taaaaagttt gatatcgagc tcacacagca 1676581 tcaccgtgcg atctatgata ctgaggcaac cgcttatttg cttctgaaaa tgctgaaaga 1676641 cgcagctgaa aaaggtattc agtaccatga tgagttgaat gaaaatatgg gtcagtccaa 1676701 tgcttatcaa agatcaagac cgtatcatgc aacattactt gccgtgaaca gcacgggact 1676761 taaaaattta tttaagcttg tgtcactttc tcatattcat tatttttaca gagtgccgcg 1676821 tattccgaga tctcagcttg agaaatacag ggaagggctt ctgatcggtt ctgcttgtga 1676881 caggggagag gtttttgagg gaatgatgca aaaatcgcct gaagaggtgg aagatatcgc 1676941 gtcattctat gattaccttg aggttcagcc gcctgaagtg tatcgtcact tgctggagct 1677001 tgaactggtc cgtgatgaaa aagcgctgaa agaaattatt gcgaatatca cgaagctggg 1677061 ggaaaagctt aataaaccgg ttgttgctac gggaaatgtt cattacttga atgatgagga 1677121 taaaatctac agaaagattt taatatcctc acaaggcggg gcaaatccgc tgaataggca 1677181 tgaactgccg aaagtgcatt tcagaacgac agacgaaatg cttgaagctt tttctttctt 1677241 aggtgaagaa aaagcgaagg agatcgtagt caccaatacc caaaaggttg cttctttagt 1677301 tgatgacatc aagccgatta aagatgattt atatacgccg aaaatcgaag gcgctgatga 1677361 agagatcaga gaaatgagct atcagcgtgc aagaagcatt tacggggaag agctgcctga 1677421 aattgtcgaa gcgcggattg aaaaagagtt aaagagtatt attggccacg gatttgctgt 1677481 tatttacttg atctctcaca aacttgtaaa acgttcacta gatgacgggt atctcgttgg 1677541 ttcccgtggt tccgtaggat cttcattagt tgcgacactt actgagatta ctgaggtaaa 1677601 cccgctgccg ccgcactatg tttgtcctga gtgccagcat tctgagttct ttaatgacgg 1677661 ttctgtcggt tctggttttg acctgcctga caagacatgc cctcattgcg gaacgccttt 1677721 gaaaaaagac ggccatgata ttccatttga aacgttctta ggatttaaag gggacaaagt 1677781 acctgatatc gatttgaact tctcagggga atatcagccg caagcacaca attacacaaa 1677841 agtattgttc ggagaagaca atgtatatcg tgcgggaaca ataggcacgg tggcagaaaa 1677901 aacagcctac ggttatgtaa aaggctatgc cggagacaac aatcttcata tgcgcggtgc 1677961 cgaaatagat cggctcgtac agggatgcac aggtgtaaaa cgtacaactg gacagcaccc 1678021 tggcggtatt atcgtagttc cggattatat ggatatttat gatttttcac cgatccagtt 1678081 cccggcagat gccacaggtt cagagtggaa aacgactcat tttgatttcc actccatcca 1678141 tgacaacctg ttaaaacttg atattctcgg acacgatgac ccgactgtta ttcggatgct 1678201 tcaagactta agcggaatag atccgaaaac aattccgacg gatgatcctg aagtgatgaa 1678261 gatcttccag ggaaccgaat cactcggtgt gactgaagaa cagattggct gtaaaacggg 1678321 cactcttgga attcctgaat tcggaacccg atttgtccgg cagatgcttg aagatacaaa 1678381 gccgaccact ttttctgagc tcgttcagat ttcaggcttg tctcacggaa ctgatgtatg 1678441 gcttggcaat gcacaggagc tcatccacaa taatatttgt gagctgagtg aggttatcgg 1678501 ctgccgtgat gacattatgg tttatttaat ctatcaaggc cttgagccgt cccttgcctt 1678561 taaaatcatg gaattcgtgc gtaaaggaaa aggattaacg cctgaatggg aagaagaaat 1678621 gaaaaataac aatgtcccag actggtatat tgattcctgt aaaaagatta aatacatgtt 1678681 cccgaaagcc cacgccgcgg catatgtctt aatggcagtc cgcattgctt actttaaagt 1678741 gcatcatgct cttttgtatt atgcggctta ttttaccgtt cgtgcagatg actttgatat 1678801 tgatacaatg atcaagggct ctacagcaat cagagcggta atggaggata taaacgctaa 1678861 aggacttgat gcttcaccga aggaaaagaa ccttctgact gttttagaat tagcgcttga 1678921 gatgtgtgag agaggctatt cattccaaaa agtcgattta tatcgctcca gcgccacaga 1678981 gtttattatt gacggcaaca gtcttattcc gccgtttaac tctattccag ggttagggac 1679041 gaacgctgct ttgaacattg taaaagctcg cgaagaaggc gaattcctct caaaagaaga 1679101 tttgcaaaag agagggaaag tatcaaaaac gattttagag tacttagatc gccatggctg 1679161 tctggagtca ctgcctgatc aaaaccaatt gtcactgttc taatatggaa agcagaattt 1679221 ctcagaaatt ctgcttctat gcatacataa gcgcaaaaag tgccatcgta atattagagt 1679281 ttctgtcact tgcttaggta tgaaggtaag cgtatatcca tttgcaataa aaatatggtt 1679341 atggtatagt tttattggaa atgctaacga ttaccgaggc aaagagtggg gaaacccgct 1679401 cttttgtatt gaacaggaga attttgtctc gacatgttca tcgtttactt tttagcccct 1679461 gctcttttga agcagggttt ttatgcagag tgacgagacg aatatgagat cgacagcaca 1679521 aggaggaaga acatgagcaa aaaagtgact gacaccgttc aagaaatggc tcagccaatc 1679581 gtagacagcc ttcagctgga actcgttgac attgaatttg tcaaagaggg ccaaagctgg 1679641 ttccttcgcg tgtttattga ttccgatgac ggtgtggata ttgaggaatg tgccaaagta 1679701 agcgaagctt taagcgaaaa gcttgatgag gcagacccaa tcagccaaaa ttactttctt 1679761 gaagtctcat ctccaggagc tgagcgtccg ctaaagaaaa aagccgattt cgaaaaatca 1679821 ctaggaaaaa acgtatacat taagacgtat gagcctattg acggcgtaaa agtgtttgaa 1679881 ggtgaactgg ctgaatttga tggacaaaca gtgacagttg agatcacgat caaaacaaga 1679941 aagaaacgga tcaatattcc gtatgaaaag atagctaatg caagattagc tgttacattc 1680001 taatgaatac aaatgtttta aggggggaga ccgttaaatg agcagtgaat tattagatgc 1680061 tctcacgatt cttgaaaaag aaaaaggcat cagtaaagaa attatcatcg aagcaatcga 1680121 agctgcgtta atttctgctt ataagcggaa ttttaatcaa gcgcaaaatg tacgggtgga 1680181 tctaaaccgt gaaactggct ccatccgtgt atttgcaaga aaagatgtcg ttgacgaagt 1680241 atacgaccag agattagaaa tctcaattga agaggcacag ggcatccatc cggaatatat 1680301 ggtcggcgat gtcgtcgaaa tcgaagttac acctaaggat ttcgggcgca tagctgctca 1680361 aacagcgaag caggtcgtca cacagcgtgt gcgcgaagct gagcgcggtg tgatttattc 1680421 tgaatttatc gaccgtgaag aagacatcat gacagggatc gtccagcgtc tggacaataa 1680481 atttatctac gtgtctttag gcaaaataga agccttgctg ccggttaatg agcaaatgcc 1680541 gaatgaaagc tacaagcccc atgaccgcat taaggtatat atcacaaaag tagaaaaaac 1680601 aacgaagggt ccgcagattt atgtgtcaag aacacatcca ggcctgttaa agcgtttgtt 1680661 tgaaattgaa gtgcctgaaa tttatgatgg aactgtcgag ctaaaatctg ttgccagaga 1680721 agccggcgac cgttcgaaaa tttctgttcg cacagatgat cctgacgttg atcctgtcgg 1680781 ttcatgcgta gggcctaaag gccagcgtgt gcaagcaatc gtcaatgaat taaaaggtga 1680841 aaaaattgac attgtcaact ggtccagtga tcctgtagaa tttgtcgcga atgcgctcag 1680901 cccttccaaa gtgcttgatg tcattgttaa tgaagaagaa aaagcgacaa ctgttattgt 1680961 tcctgattac cagctgtctc tggcaattgg aaaaagagga caaaacgcac gcttagctgc 1681021 taaactgaca ggctggaaga ttgatattaa gagcgaaacg gacgcaagag aacttggaat 1681081 ctatccgaga gaacttgaag aagatgatga gccgctcttt acggagcctg aaactgctga 1681141 atcggatgaa taagaggtga ctttaggtga ataaacacaa aaagatccca ttacgcaaat 1681201 gtgtagtgac tggtgaaatg aagcctaaaa aggaactgat ccgagttgta cggtcgaaag 1681261 aaggcgaaat ctcagtagac ccgaccggaa aaaagaatgg gcggggtgct tatttaacgc 1681321 tggataaaga gtgcatctta gcagcaaaaa agaaaaacac tttgcaaaat caatttcaat 1681381 cacaaatcga tgaccagatt ttcgatgaat tgctggaact ggcggaaaag gtgaaaaaat 1681441 aaaatgtctg gaatggaatg gtttcccttg ctgggtctgg ccaatcgagc tcgtaaggtc 1681501 gtgtcaggcg aagacttggt aataaaagaa atcaggaatg cgcgtgcaaa gcttgtcctg 1681561 cttacagagg atgcatcatc taacacagca aaaaaagtaa ctgacaagtg caattattat 1681621 aaagtccctt ataaaaaagt cgagagtcgc gcggttcttg gacgctctat cggtaaagaa 1681681 gcccgtgtcg ttgtcgccgt cactgaccaa ggttttgcga ataagctgat cagcttgctc 1681741 gattaatatt tttgggggtg aacgaatggc taaaatgaga gtatacgaat atgcaaaagc 1681801 gttaaatgtt tcaagtaagg aaattttgac cgcactgaag aacatggatt tagaagtgaa 1681861 taatcacatg gccatgcttg aagaaaaggc cattaaaaag ctagatgcca aatataaaaa 1681921 aggcggcgca gctgctaaat ctcaaaagcc agcagaaacg aacaaaaaca aacagccaca 1681981 aggggttaat cagcaatcag ctggaaatca accaaataaa attcgagacg gaaagaagaa 1682041 tgacgtgcag aataatcaat ttaacaaaaa caagaagaat aacaacaaca aaaaaaataa 1682101 acgcaacaac aacaataata aaaaccaaca tcagcaaaag cctgtaaagc cgaaaaaaga 1682161 gcttcctgag aaaattacat tctctggcac tttaacagtt ggcgcacttg ctgaagagct 1682221 tggcaaagag ccttcagaac tcattaaaaa gctgatgctt cttggcgtaa tggcaaccat 1682281 taaccaagag cttgataaag acacaatcga actcattgca tcagaatatg gtgttgaaac 1682341 agaagaggtc attgtgcttg aagaaacaga gctggaaaaa tacgaagagc ctgataatga 1682401 agaggatctt gaaattcgtc ctcctgtcgt gacaatcatg ggccacgttg accatgggaa 1682461 aacaacgctt cttgacagca tccgtaaaac aaaggttgtt gaaggggaag caggcggaat 1682521 cactcagcat atcggcgctt atcaaattga agagaacggc aagaaaatca cgttcttgga 1682581 tacaccgggc cacgccgcat ttacaacaat gcgcgcacgc ggtgcagaag taactgatat 1682641 tacgattctt gtcgtagctg ccgatgacgg tgtcatgccg caaacagttg aagcgattaa 1682701 ccatgcaaaa gcagcagagg ttccaatcat cgttgctgtg aataaaatag ataaagaatc 1682761 cgcaaaccct gaccgtgtaa tgcaagaact gacggaatac ggacttgtcc ctgaagcttg 1682821 gggcggagaa accatttttg tgccgctttc cgctttaact ggaaaaggca ttgatgagct 1682881 cgttgaaatg attttgcttg tcagtgaggt agaggaactg aaagcgaatc cgaatcgtca 1682941 ggcaaaagga acggttattg aagctgaact cgataaaggc agagggtcag tcgcgacgtt 1683001 gctcgtacag actggaacac tgcatgtcgg tgatccgatc gtagtcggca atacatttgg 1683061 ccgtgtccgt gcaatggtca acgacattgg ccgccgtgtg aaaactgccg gcccgtcaac 1683121 tccggttgaa attaccggtt tgaatgatgt ccctcaagcg ggagaccaat tccttgtctt 1683181 taaggatgaa aaaacagctc gttctgtcgg tgaagcccgt gcttcgaaac agcttgaaga 1683241 gcagcgcagc gataaagcga agctcagtct tgatgattta tttgagcaaa ttaagcaagg 1683301 tgatgtaaaa gacatcaacc tcatcgtaaa agctgacgtt caaggatctg ctgaagcttt 1683361 aacggctgca cttcaaaaaa ttgaagtaga aggcgttaaa gtgaaaatca tccatacagg 1683421 cgttggtgcg attactgaat cagacattat cttggcatct gcttccaatg caattgttat 1683481 cgggtttaat gtgagaccgg acggaaatgc taagagtacg gctgaagctg aaaatgtaga 1683541 tattcgactt caccgtatca tttacaaagt aatcgacgag attgaagctg ccatgaaagg 1683601 tatgcttgat cctgaatatg aagaaaaagt aattggtcaa gtagaagtac gccaaacatt 1683661 caaagtatct aaaatcggta caattgccgg cggatatgtt actgaaggaa ccattacgcg 1683721 cgacagcggc ctccgtttaa ttcgtgacgg cgtcgtcatc tttgaaggcg aagtagatgt 1683781 tctgaaacgc tttaaagacg atgtgaaaga agtttcacaa ggctatgaat gtggtattac 1683841 aattaagaaa tacaatgaca ttcgtgaagg tgacatcctt gaagcgtttg tcatgcaaga 1683901 aattgaaaga acgtgatcgg atttgcggag tgtgaatgca tcatttatga tgcaggatcg 1683961 ctaaaagaaa agcgtgccgt tctgaagcgg attttaacca gggttcaaaa caagttcaat 1684021 gtttcgattt cggagattgg ctatcaggac acctggcaaa gaaccagctt cggaatcgcc 1684081 gctgtttctt cctctcgcgt tcaaacagaa aaagaactgc agcgcgtcct agcgtttatc 1684141 gattcttttc ctgaaattga acggacgatc actaggacag agtggtttta acttagaggt 1684201 gattgaattg agtatgagag caaaccgtgt cggcgagcaa atgaaaaaag aactcggtga 1684261 tattatcagc cgcaagctga aagacccgag aattggtttt ctgacagtaa cggatgtacg 1684321 tgtatcaggt gatttgcaaa ttgcaaaggt gtatatctcg gttctcggtg acgagaaaaa 1684381 acgggaagaa gcgctgaaag ggctggcaaa agcgaaagga tttatccgat ccgaaatcgg 1684441 cagccgcatc agacttcgaa aaacgcctga aattgaattt gagttcgatg aatcaatcga 1684501 ttacgggaat cggatcgaaa cactgattca cgaattacat tcagagaaac catctgaata 1684561 aaaaaagaga ggataggcgt atatcgtctg tcctctttct tcgtttataa gaaaaaaact 1684621 caaaagaagg agtgaaaggc aaatggttaa cggagttctc cttttacata aacctgttgg 1684681 catgacatcg cacgactgtg tcatgaagat ccgaaagctg ttaaaaacaa aaaaagtagg 1684741 acatacagga acgctcgatc cggaagtatc aggcgtgctt ccgatttgtg taggaagagc 1684801 gacaaaaata gtcgaatact taactgaaaa atctaaaacg tatgatgcag aaataacatt 1684861 gggcttttca accacaacag aggatcaaac cggagaaacg gtggaaacaa agcctgtcaa 1684921 tcacgacatt gataaagcgg atgtagaaaa ggttttaaac agtttaaagg ggaaacaaga 1684981 acaaattccg cccatgtatt ccgctgtaaa agtaaacggc aaaaaattat acgaatacgc 1685041 aagagcaggg attgaagtag aacgtccgaa acgtatgata accattgaag acattgccct 1685101 gacaacagag attaaacatc atggagaaac cgcaagcttc cggtttacag tgacttgctc 1685161 caaagggacc tatgtaagga cgctggcggt catgatcgga gaaaagctcg gatatccggc 1685221 ccatatgtct catttaatcc gtacggcatc cggagatttt tctctcgacg aatgctttac 1685281 ttttgatgaa ctcgaagcac aggcccaatc cggaaccgtg gaagagcata cagttcctat 1685341 tgaacgtgcg ctcaatcatt tgccgaaatg gatcataagt gatacattag ctaagaaagt 1685401 agaaaatggg gctttgcttg agacgcccga gcagttttct gaaatgacaa gtggagaccg 1685461 tattgccgtc tttactgaat ccggaacctg cttggcgatc tatttccctc atcctgcaaa 1685521 aaaagggctg ttaaagccgg caaaagtatt gatgcaaaaa agcgaacaat agaaaaaagg 1685581 tgaccgttct gtgaagacga tacatattac acatcctcat catttaataa aagaggagca 1685641 ggcaaaatca gtgatggcgt taggttattt tgacggcgtt catctcgggc atcaaaaggt 1685701 aatcggcaca gcgaagcaaa tagccgaaga aaaaggtctg acattagctg tgatgacctt 1685761 tcatccccat ccttctcacg tgttgggcag agataaggaa ccaaaggatc tgattacgcc 1685821 tcttgaagac aaaataaacc aaattgaaca attaggcaca gaagttctgt atgtcgttaa 1685881 atttaatgaa gtgtttgctt ctctttctcc taagcagttt atagaccagt atattatcgg 1685941 ccttaatgtg cagcacgcag tggcaggctt tgactttacg tacggcaaat acggcaaggg 1686001 aacaatgaag accatgccgg atgatttaga cggaaaagct gggtgcacaa tggtagaaaa 1686061 attaacggag caggataaaa aaatcagttc ttcgtatatc cgtaccgcgc ttcaaaacgg 1686121 agatgttgaa ttggcgaatg tcttgcttgg acaaccttat tttattaaag gaattgtcat 1686181 tcatggtgat aaaagagggc ggaccatcgg gtttccgaca gcgaatgtcg gtttaaataa 1686241 cagctatatc gttccgccca caggtgtata tgccgtaaaa gcggaagtga acggcgaagt 1686301 ttacaatggc gtttgcaata ttggctataa gccaacgttt tatgaaaagc gccctgaaca 1686361 gccttccatc gaggtcaatc tgtttgattt caatcaagag gtatatggag ccgctataaa 1686421 aatcgaatgg tacaaacgga ttcggagcga gcggaaattc aatggcatca aagaattaac 1686481 tgagcaaatt gagaaagata agcaggaagc catccgttat ttcagcaatt tgcggaaata 1686541 acttgcaacg cacgcaaatt ttattctaaa atatttgcat ataggcacga tttttagtat 1686601 gatagttttc gtagtcttaa aaccattgct tggcaatccg aagtcaccga cggttgctag 1686661 gtaactgggg ctaaatatga tttggaggtg aaacaggatg gcaattactc aagagcgtaa 1686721 aaaccaactc atcaatgagt tcaaaacaca cgaatctgat actggatctc cagaagttca 1686781 gatcgctatc ctaactgact caattaacaa cttgaacgag catttacgta ctcacaagaa 1686841 agaccaccac tcacgtcgcg gtcttcttaa aatggtaggt aagcgtcgta atcttcttac 1686901 gtatctgcgt aataaagacg taactcgtta ccgtgagtta attaacaaac taggcttacg 1686961 tcgataatcg taaaaagcgg gaggattccc gcttttttat cgtattaaag cgaaatttct 1687021 tataacaaat cattgaaatc cttttacata ctactttgac attgatatgt tcaattcatt 1687081 tcgttcataa taggagtaat tgattatttc acacaacgaa gagaggagtt cgtaattgta 1687141 tgggacaaga aaaacatgtc tttaccatag attgggccgg aagaacgctt accgttgaaa 1687201 ccggccagct tgccaaacag gcaaatggtg ctgtgatgat ccgctacggt gatacagcag 1687261 tacttagtac agcaaccgct tcaaaagaac ctaaaccgct tgatttcttc cctcttactg 1687321 taaactatga agaaagatta tatgcggtag ggaaaattcc gggcggattt attaaaagag 1687381 aaggacgtcc aagtgaaaaa gcggttcttg ccagccgttt aattgaccgt ccgatccgtc 1687441 ctttgtttgc cgatggattc cgtaatgaag ttcaagtcat cagcattgtc atgagtgttg 1687501 accaaaactg ctcttcagaa atggctgcca tgttcggttc atctcttgca ctttctgtat 1687561 cggatattcc gtttgaagga ccgattgcag gggttactgt cggacgcatt gatgatcaat 1687621 ttatcattaa cccgacagtc gatcagcttg aaaaaagcga tatcaatctt gtcgttgccg 1687681 gcacgaaaga tgcgattaac atggtagaag cgggagcgga cgaagttcct gaggaaatca 1687741 tgcttgaggc cattatgttc ggccatgaag agattaaacg cctgattgca ttccaagaag 1687801 aaattgttgc agcagtcggc aaagagaaat ctgaaattaa gctctttgaa attgatgaag 1687861 agcttaatga aaaagtaaaa gctttggcag aagaggatct gctgaaagcc atccaagttc 1687921 atgaaaagca tgcccgtgaa gatgccatta acgaagtgaa gaacgcagtt gtggcaaaat 1687981 tcgaggatga agaacatgat gaagacacaa tcaagcaagt gaagcagatt ttatccaagc 1688041 ttgtgaaaaa tgaagttcgc cgcctgatta ctgaagagaa agtaagaccg gacggccgcg 1688101 gtgtcgatca aatccgtccg ctctcttcag aggttggcct cttgccaaga acgcacggtt 1688161 caggtctatt tacaagggga caaactcagg ccctcagcgt atgtacgcta ggtgctctgg 1688221 gagatgtgca aatccttgac ggcttaggtg tcgaagagtc gaaacggttt atgcatcatt 1688281 acaacttccc gcaattcagc gttggggaaa caggaccgat gcgcggaccg ggacgtcgtg 1688341 aaatcggaca cggagcactg ggtgagcgtg cgcttgagcc agttattccg tctgaaaaag 1688401 acttccctta tactgtccgt cttgtttcag aagtgcttga atcaaacggt tctacatctc 1688461 aagcaagcat ttgcgcaagc acacttgcaa tgatggatgc cggtgtaccg attaaagcgc 1688521 cagttgctgg tattgcgatg ggtcttgtca aatcaggcga acattacact gtcttgactg 1688581 acatccaagg catggaagac gcgctcggag atatggactt taaagtagcg ggaactgaaa 1688641 aaggcgtaac ggccctgcaa atggacatta aaattgaagg cctttccaga gagattcttg 1688701 aagaagcgct tcagcaggcg aaaaagggca gaatggaaat cctcaacagc atgcttgcaa 1688761 cattaagcga atcaagaaaa gagctttctc gatatgcgcc taagatctta acaatgacca 1688821 ttaatcctga taaaatccgc gatgtcatcg gaccaagcgg gaaacaaatc aataagatca 1688881 tcgaagaaac cggtgttaaa attgatattg agcaggacgg cacaatcttt atttcctcta 1688941 cagatgaaag cggcaaccaa aaagcgaaaa aaatcatcga agaccttgtg agagaggttg 1689001 aagtcggcca actttaccta ggtaaagtga aacggattga aaaattcggg gctttcgttg 1689061 aaattttcag cggaaaagac ggtttggtgc acatttcaga gcttgcgctt gaacgcgtag 1689121 ggaaagttga agatgttgtg aaaatcggag acgagattct tgtcaaagtc actgaaattg 1689181 ataaacaagg acgagtgaat ttatcccgca aagcggtgct ccgtgaagag aaagaaaaag 1689241 aagaacaaca atcttaaatg aaaacataaa aggagcctgg gagacccggc ttctttattt 1689301 tgaagctttt caaaagcagg cgggttctac cttgtccttc tccttcataa tgtgaggtga 1689361 gggggggaca gaacatgtac aaaaaatttg taccgtttgc cgttttttta tttctttttt 1689421 ttgtctcatt tgagatgatg gaaaatccgc atgcacttga ttatataggg gcaatgaaaa 1689481 aagatacggt gactgtcacg gcgtcaaaag acccgttata tgaagaattg cttcaaaaag 1689541 cgccggagta cgaagttaag ccccagaatg caagaattga taaagtgtgg aaaagcattc 1689601 caggctacaa tggattaaag gtcaatattg aacaatcata taaaaaaatg aaacagcatg 1689661 gtaagtttcg ggaaaaagat ttggtgtaca gtcaagtaaa accaagtgtt catcttgagt 1689721 cacttcagcc tgagcctatt tataaaggaa atcctgacaa accgatggtg gcttttttaa 1689781 tcaatgtggc atggggaaat gagtatttgg aaaaaatgct tcctattctg caaaagcacc 1689841 aggttaaagc tacgttcttt ttagaaggca attgggtgag aaacaatgta cagctcgcta 1689901 agaagattgc aaaagacgga catgaaatcg gaaatcattc atacaatcat ccggatatga 1689961 gcaaactgac tacaggaaga atttccgagc agctcgacaa gactaatgaa caaatagaac 1690021 aaacgatcgg cgttaagcca aagtggttcg ctccgccaag cggaagtttc agaaaagcgg 1690081 ttatcgacat tgcagcagag aaacagatgg gaacagtcat gtggacagtt gatacaatcg 1690141 attggcaaaa gccggctccg tctgtacttc agacgagagt gttaagcaag atacataatg 1690201 gtgccatgat tttaatgcat ccgactgacc ctacggcgga aagtcttgaa gcgctgatta 1690261 cacagataaa agacaaagga tatgcgcttg gaacagtcac tgaactaatg gatgaaacaa 1690321 gactattgaa gtaacagatg aaggcagctt gtctttgaat aggaggaaca aatttgatta 1690381 aacgatatac gtgtcaaaat ggtgtaagaa ttgtgctgga aaataacccg acagtccgtt 1690441 ctgttgcgat cggcgtatgg atcggcacag gttcgagaca tgaaacgccg gagataaacg 1690501 gaatttctca ctttttagag cacatgttct ttaaagggac gagcacaaaa tctgcacgcg 1690561 agatagcaga atcttttgat cgtattggcg gccaggtcaa tgcgtttact tcaaaggaat 1690621 atacctgcta ctatgcaaag gtgcttgacg agcatgcgaa ttacgcgctg gacgtattag 1690681 cagatatgtt ctttcattca acgtttgatg aaaacgagct gaaaaaagag aaaaatgtag 1690741 tatatgaaga aattaaaatg tatgaagatg cgccggacga cattgtacat gatttattga 1690801 gcaaagccac ttacggcaat cattctttag gctacccaat tttaggaacg gaagaaacgc 1690861 ttgcttcctt taacggtgac tctctcagac aatacatgca tgattattat acgccggacc 1690921 gagtggtgat ttcggtagcg ggcaatatat ctgacagttt tatcaaagat gtagaaaaat 1690981 ggttcgggtc atacgaggcg aaaggcaaag cgacaggcct tgagaagcct gagttccaca 1691041 cggaaaaact gacgagaaaa aaagaaacag agcaggctca tttgtgcctt ggatttaaag 1691101 gcttagaggt tggccatgaa cgtatttatg atttaatcgt cctcaacaat gtgctcggag 1691161 gcagcatgag cagccggctg ttccaagatg tgcgtgaaga taaaggactt gcttattctg 1691221 tttacagcta tcacagctca tatgaggaca gcggaatgct aacgatttac ggcggaacgg 1691281 gtgcaaatca gcttcagcag ctgtcggaaa caattcaaga aaccctggcc acattaaaac 1691341 gtgacggcat tacctcgaaa gaactggaaa acagcaaaga gcaaatgaag ggaagcttaa 1691401 tgctgagctt agaaagcaca aacagcaaaa tgagccgaaa cggaaaaaat gaactgctgc 1691461 tcggcaaaca taaaacatta gatgaaatta tcaatgaatt aaacgccgtg aacttagagc 1691521 gtgttaatgg ccttgccaga caattgttta ccgaagacta tgcattagca cttatcagcc 1691581 cttccggcaa tatgccgtct taaaaaggaa agcctgcccc ataatggagc aggcattttt 1691641 taatcccttt catcatacat agtacaaggg ggtgacagac atgcggctca gtgaattatc 1691701 gggaaaggaa attgtagaca tcaaaagagc tgaacggctc ggagtgctcg gccagaccga 1691761 tttggaaatc aatgaacagg atggacagat tacagcactc ctcattccca cagttaagtg 1691821 gtttggtttg agaaagcaag gtcatgacat tcgtgtccca tggcaccata ttcaaaagat 1691881 cggttcagat atgattatat tagatgtacc tgaggaaatg cctcctcgac aagagtaaat 1691941 agcccaattg actgtgaagc gggctctaaa gaaaacatct gaaacatcgg ctgccggagc 1692001 cgatgttttt ttatatggaa aaagcgcatc ttttatattc accggtattt ccttttgatc 1692061 ataagatgaa ggggagctta acaactagag atccagtata tacaaagaag gtgaacgttt 1692121 agaatgttaa ccggattgaa aattgcagtt atcggcggtg acgcaagaca gctcgaaatt 1692181 ataagaaagc tcactgaaca gcaggctgac atctatcttg tcggttttga ccaattggat 1692241 cacggtttta ccggggcagt aaaatgcaat attgatgaaa ttccttttca gcaaatagac 1692301 agcatcattc ttccagtatc cgcgacaaca ggagaaggtg tcgtatcgac tgtattttcg 1692361 aatgaagaag ttgtgttaaa acaggaccat cttgacagaa cgcctgcaca ttgtgtcatt 1692421 ttctcaggaa tttctaacgc ctatttagaa aacattgcag ctcaggcaaa aagaaaactt 1692481 gttaagctgt ttgagcggga tgacattgcg atatacaact ctattccgac agtagaagga 1692541 acgatcatgc tggctattca gcacacggat tatacgatac acggatcaca ggtggccgtt 1692601 ctcggtctgg ggcgcaccgg gatgacgatt gcccgtacat ttgccgcgct cggggcgaat 1692661 gtaaaagtgg gggcaagaag ttcagcgcat ctggcacgta tcactgaaat ggggctcgtt 1692721 ccttttcata ccgatgagct gaaagagcat gtaaaagata tagatatttg cattaatacc 1692781 ataccgagta tgattttaaa tcaaacggta ctttctagca tgacaccaaa aaccttaata 1692841 ttggatctgg cctcacgtcc cgggggaacg gattttaaat atgccgagaa acaagggatt 1692901 aaagcacttc ttgctcccgg gcttccaggg attgtcgctc ctaaaacagc tgggcaaatc 1692961 cttgcaaacg tcttgagcaa gcttttggct gaaatacaag ctgaggaggg gaaataagga 1693021 tgtcgtcatt aaaaggaaaa agaatcgggt ttgggctgac cgggtcgcat tgcacatatg 1693081 aagcggtttt cccgcaaatt gaggagttgg tcaacgaagg agctgaagtc cgtccggttg 1693141 tcacatttaa tgtaaaatct acaaataccc gatttggaga gggcgcagaa tgggttaaaa 1693201 aaattgaaga cctgactgga tatgaggcca ttgattcgat tgtaaaggca gaacctcttg 1693261 ggccgaagct gccccttgac tgcatggtca ttgcgccttt aacaggcaat tcaatgagca 1693321 agctggcaaa tgccatgacg gacagcccgg tgctgatggc ggcaaaagcg acaatccgga 1693381 acaatcggcc tgtcgttctg ggtatctcga caaatgatgc tcttggttta aacggaacaa 1693441 atttaatgag gctcatgtca acaaaaaata tcttttttat tccattcggg caagatgatc 1693501 catttaaaaa accgaattca atggtagcca aaatggatct gcttccgcaa acgattgaaa 1693561 aggcactcat gcaccagcag cttcagccga ttctagttga gaattatcag ggaaatgact 1693621 aaatttacag aaaatctttc ccaaactaaa aaattcggtc atcacccgca tattctatgg 1693681 taaaataaaa cgtaaaatca tagtcaaatc aattcaatga agctgattgg cggaaggagt 1693741 tttacagatg ggaagaggtt tacacgtagc tgttgtcgga gcgacagggg ctgtgggaca 1693801 acaaatgctt aaaacacttg aagacagaaa ctttgaaatg gacacactta cattgctatc 1693861 ttcaaaacgc tctgcgggga caaaagtcac gtttaaaggc caagagctga ctgttcagga 1693921 agcttctcct gagagctttg aaggggtaaa tattgctttg ttcagcgccg gcggaagcgt 1693981 atcacaagca ttggcaccag aagctgtaaa acgcggcgct attgttatag ataatacgag 1694041 tgcgttccgc atggatgaaa atacaccgct tgttgtgcca gaagtgaatg aggcagactt 1694101 gcatgaacac aacggcatta ttgccaatcc aaactgctct acaatccaaa tggttgcggc 1694161 acttgaaccg atccgcaaag catatggctt aaacaaggtc atcgtatcaa cttaccaggc 1694221 agtatcagga gcgggtaatg aagctgtaaa agagctttac agccaaacac aggcgatttt 1694281 aaataaagaa gaaatagagc ctgagatcat gcctgtaaaa ggtgacaaaa aacactatca 1694341 aatcgccttc aacgcgattc cgcaaatcga taaattccaa gataacggct atacgtttga 1694401 ggaaatgaaa atgataaatg aaacgaaaaa aatcatgcac atgcctgacc ttcaagtagc 1694461 ggctacatgt gtgagactgc caatccaaac tgggcactca gagtccgtct acatcgaaat 1694521 agaccgtgat gacgctacag ttgaagatat taaaaatcta ttgaaagaag ctccgggcgt 1694581 gacacttcag gatgatccaa gccagcagct ttatccgatg cctgctgatg ctgtcggcaa 1694641 aaacgatgtg tttgtaggcc gcatccgcaa agacttggac agagcaaacg gttttcattt 1694701 atgggttgtt tctgataacc tattaaaagg cgcggcatgg aactctgttc aaattgcaga 1694761 aagcctgaaa aaactaaacc tcgtataaaa gagagaattt tctaaagacg aatagaagag 1694821 agtaaggcgc tatcagcctg ctctcttctg ttacgtccga ataatttgga gtgaaaacag 1694881 tgaagataat tgttcaaaag ttcggcggaa catcagtaaa agatgataaa ggccgcaaac 1694941 tggctttagg gcatattaaa gaagcaatca gtgaaggata taaggttgtc gttgtcgttt 1695001 cagcgatggg ccgaaaaggg gacccgtatg caacagattc tttgctcggg ctgctttacg 1695061 gcgatcagtc agcgatttct cctagggagc aggatttgct tttatcttgc ggagagacta 1695121 tttcctctgt cgtctttaca agcatgctgc ttgataacgg tgtgaaagca gctgcgctga 1695181 caggggctca ggctggcttt ttaacgaatg atcagcatac taatgcgaaa atcattgaaa 1695241 tgaaaccgga gcgtttattc agtgtgctcg ccaatcatga tgcggtagtc gtcgcaggct 1695301 tccagggcgc aactgaaaag ggtgatacaa caacaatcgg cagagggggc agcgatacgt 1695361 ctgcagccgc actcggagca gctgttgatg cggaatacat cgatattttc accgatgtag 1695421 aaggcgtgat gactgctgac ccaagagtgg tagaaaatgc aaaaccgctt cctgttgtga 1695481 cgtatacgga aatctgcaac ctggcgtatc agggggccaa ggtcatttct ccgcgtgctg 1695541 tggaaatcgc aatgcaggcc aaggttccga tccgcgtccg ttcgacttat tcgaatgata 1695601 aaggcacatt ggtgacatca catcactctt ccaaggtcgg cagtgatgtt tttgaaaggc 1695661 tgattacggg aatcgcccat gtcaaagatg tcacgcagtt caaagtgcct gcgaaaatcg 1695721 gccagtataa cgttcagact gaagtgttca aggctatggc aaacgctgga atcagtgtcg 1695781 atttctttaa cattacacct agtgaaatcg tctatacggt agccggaaat aaaacagaaa 1695841 cagctcagcg tattttaatg gatatgggct atgatccaat ggtgacgaga aactgcgcga 1695901 aggtatcggc ggtcggcgcg ggcattatgg gtgttcccgg tgttacgtcc aaaattgtat 1695961 cggctctttc agaaaaagaa attccgatcc ttcagtcggc tgacagccat acgacgatat 1696021 gggtgctcgt ccatgaagcg gatatggttc ctgctgtaaa cgctttgcat gaagtgtttg 1696081 aactttcgaa gtaaatgtga ttgaatcatg atgaggtgaa taaaatgaat ttcggaaatg 1696141 tgtctacagc gatgattaca ccctttgaca ataaagggaa cgtagacttt caaaaactgt 1696201 ctacactgat tgattacttg ttgaaaaacg gaacggattc tttagtagta gcgggaacaa 1696261 ctggagaatc tccgaccctt tcaactgaag aaaaaattgc gctttttgaa tatacggtaa 1696321 aagaagtaaa cggacgggtg cccgttatcg ctggtactgg gagcaacaac acgaaagatt 1696381 ccattaagct gacaaaaaaa gctgaggaag cgggcgtgga cgctgttatg cttgttaccc 1696441 cgtattacaa taaaccttct caagaaggaa tgtaccagca ttttaaagca attgcggcag 1696501 agacatctct tccggttatg ctctataatg ttcctggccg tacggttgct tctcttgctc 1696561 ctgaaacgac gatccgtttg gcggcagaca ttccgaatgt ggttgcgatt aaagaagcga 1696621 gcggagacct cgaagcgatt acaaaaatta ttgctgaaac acctgaagac ttctatgtct 1696681 attcagggga tgatgctcta acgcttccaa ttctttcagt tggaggtaga ggagttgtgt 1696741 cagtggcgag ccatattgca ggcactgata tgcagcaaat gatcaaaaat tatacgaatg 1696801 ggcaaacagc taatgcggca ctgattcatc agaaactgct gccgattatg aaggaactgt 1696861 ttaaagcgcc taatcctgct ccagtcaaaa cagcgcttca gctgagaggt cttgatgtcg 1696921 gttctgtgcg tctgcctcta gtcccattaa ctgaggatga acgtctgagc ttaagcagca 1696981 cgatcagcga actgtaagaa aatttcatac agtgaaacaa acgcggtcat tctcacattc 1697041 agctgagttt gaccgtttct tttacatatt ggttttccct aaaccttctg ctttatcttg 1697101 ttttctaaat ttactttcag ttataatagg aacaagtgat gatggacggg tatgagacta 1697161 ggaggatata gattttgaaa aagaaaaata cagaaaacgt tagaattatc gcccttggcg 1697221 gtgtcggaga gattgggaag aacctttatg tcattgaaat tgactcagac atatttgtcg 1697281 ttgatgccgg ccttatgcat ccagaaaacg aaatgctcgg tattgatgta gtgattcctg 1697341 acatatcata tttgattgaa cgggctgacc gcgtcaaggc aatcttttta acgcacgggc 1697401 acgatgaaaa tatcggcggc gttttttact tattaaacaa gctgtccgtt ccagtgtacg 1697461 gaacaaaact gacgcttgca ctgttaagag agaaattaaa acaatacgga cataaccgaa 1697521 aaactgattt aagagaaatt cactccaaat ctgtcattac atttgaatca acaaaggtat 1697581 cgttctttag aacgattcac agcattcctg attctgtagg tgtgagcttt aaaacatcac 1697641 ttggatctat tgtatgcacg ggagacttca aatttgacca aacacctgca cttaatcaga 1697701 cgtgcgacat tggcgagatc gccaagatcg gcaatagcgg cgtgctcgct ctgctttctg 1697761 acagtgcaaa tgcggaacgg ccgggttaca ccccttcgga agcggctgtc agcggagaaa 1697821 tttcggatgc gctgtataat tcacagaacc gggtgattat tgctgttttc gcatccaata 1697881 ttaaccggat tcagcaagtc attcatgcag cggctcaaaa tggcagaaag attgccgtag 1697941 ccggaaaaaa tcttcaatct gtcctgcagc tggcgagaaa gttaggatat attgaagcag 1698001 atgatgaatt gtttatttct gtacaggatg tcaaaaaata tccgaagcgc gaagtggcca 1698061 ttattacagc cggaagccaa ggtgaaccat tagctgcttt gacaagaatg gcaaacaaag 1698121 ctcacaaaca gctgaacatt gaagaagggg atacggtggt cattgcgtca actccgattc 1698181 ccgggcagga actcatttac tctaaaacag tagatcttct tgcgagagcc ggtgcacaag 1698241 tcatctttgc ccaaaagcgt gttcatgtat caggccacgg ctcacaagaa gagttaaagc 1698301 tgatgatcaa cctgcttaaa ccaaaatatt tgattcctgt aaacggcgaa tacagaatgc 1698361 aaaaagctca ttcaaaaatc gctgaagaaa ccggcatgaa gcgcagtgac atcttcttaa 1698421 ttgaaaaagg cgacgtcgtt gaattccgcg gccaaaacgt aaaaattggg gataaagttc 1698481 cttacggcaa tattttaatt gatggtttag gtgtcggtga tatcggcaat atcgtattga 1698541 gagaccgccg cttgctttca caggacggaa ttttaatcgt tgtcattaca cttgataaac 1698601 aaaagaaaca tcttgtatca ggaccagaaa ttatcactcg cggctttgtt tatgtaagag 1698661 agtctgaagg tcttatcgta caggctactg agcttgtacg gtccatcgtg acagaagcga 1698721 ctgaaacatc aaatgtcgaa tggtcaacgc tgaagcaggc aatgcgggat gctttgaacc 1698781 aattccttta tgaaaaaacg aaacgtaaac cgatgatcat cccaattatt atggaagtat 1698841 aatgactgac taaagaccgg agctgctccg gtctttattt tttgtccttc aagccgggat 1698901 tgaatgaagt atctttgttc ataatacaaa gagaaactcg gaaaggatga aagcgagatg 1698961 gatcatcgta tggaaaacac agaagaagag cgtcctgaaa aaaatgatgc gaaggacagc 1699021 attatgaata aaatacagca gcttggtgaa acgacgcttc cgcagctgcc ccaagataca 1699081 aatattcatt gtctgaccat tatcggacaa attgaaggcc atgttcagct tcctccgcaa 1699141 aacaaaacaa caaaatatga acatgtcatc ccgcagattg tggcaattga acaaaatccc 1699201 aaaattgaag gcttgctgat catattaaat actgtcggag gagatgttga agctggtctt 1699261 gccatagcgg aaatgcttgc atctttatcg aaaccgaccg tttctatcgt gcttggcggg 1699321 gggcattcaa tcggcgttcc gattgctgta tcctgtgatt acagctatat cgccgaaaca 1699381 gcaacgatga cgattcatcc agttaggctc accgggctgg tcatcggggt gccgcaaacg 1699441 tttgaatacc tggataagat gcaagaaaga gttgttaaat ttgtgacaag ccattccaat 1699501 ataaccgaag agaagtttaa agagctaatg ttttcaaaag gaaacttaac acgcgatatc 1699561 ggaacaaatg tagtcggtaa ggatgcagtt aaatacggat tgatcgatca cgcaggcggt 1699621 gtcggacagg caatcaataa actgaatgag ctcatcgatg aagcaaggaa agaagaagga 1699681 cggatgattc aatgattctt tataccgtga tgcctcagga aattgtgttt gcagaacaga 1699741 accaagagac aagcgcacat gagcaaattg aatataaagg tgtaccgctt ctagtcgaaa 1699801 tgaaagggaa tgaagcggaa gtcattcaaa tcatgagcac caatccaatg cattttctgc 1699861 atccggacat ttcaccggga caaaagctga aattaaacgt ataagaatcc aacccttttt 1699921 taagggcaaa atatgctata ataggggaat cctacagaaa aaacgcagcc tgtaaacggc 1699981 tgctttcttc attatgtatg aacttacatt ttttaacgca gtaaggtgat gagtgtggca 1700041 aagaaaaaac gaaaatcaag aaaaaaacag gcgaaacagc tcaatataaa atacgagctc 1700101 aacggattgc tgtgtatagc catttcaatt atcgcaatct tgcagctggg ggtagtcggg 1700161 caaacgttta tctatttgtt ccgctttttt gctggagagt ggtttatttt atgcttgtta 1700221 ggtttattgg tgttaggagt ctcactgttt tggaagaaaa aaaccccaag ccttttaacg 1700281 agacgaaagg ccgggttgta ctgtattatc gcaagcatat tgctgctttc tcacgtgcag 1700341 ctatttaaaa atttgacgca caaagggtct attgagtctg caagcgtggt gcgcaatacg 1700401 tgggaattgt ttttaatgga catgaatggc agctctgctt cacctgattt aggcggaggg 1700461 atgatcggtg cgctgctgtt tgcggcttca cactttttgt ttgcgtcgac tggttctcag 1700521 atcatggcaa ttgtcatgat tttgatcgga atgattttag taacaggacg ctcgctgcaa 1700581 gaaacgctaa aaaagtggat gagcccgatt ggacgtttta taaaagaaca atggttagca 1700641 tttattgatg acatgaaatc cttcaaatca aatatgcagt catcgaaaaa aacgaaagcg 1700701 ccgagcaaaa aacaaaaacc ggcccgcaaa aaacagcaaa tggaaccgga gcctcctgat 1700761 gaagaggggg attatgaaac agtatcgcct cttattcatt cagagccgat tatctcaagc 1700821 ttttctgatc gtaatgaaga ggaagagtct ccagttatag aaaagcgcgc cgaacctgtg 1700881 tcgaagccgc ttcaggacat ccaaccggag acaggtgatc aggaaactgt ttctgctcct 1700941 cctatgacct ttacagagct cgaaaataag gattacgaga tgccgtcact ggatttgctg 1701001 gcagatccga agcataccgg ccagcaggct gataaaaaga atatttatga aaatgcgaga 1701061 aagcttgaac gcacattcca aagctttggc gtaaaggcga aagtcacaca ggttcatctc 1701121 ggaccggccg taacaaaata tgaagtatat cctgatgtcg gagtgaaggt tagcaaaatt 1701181 gtcaatttaa gcgatgattt agcgcttgcg cttgctgcga aggatatcag gatcgaagcg 1701241 cctataccag gcaaatcagc aatcggaatt gaagttccaa acgcagaagt ggcaatggtt 1701301 tcgctgaaag aagtgctgga gtctaaattg aatgacagac cggatgcgaa gctgttaatt 1701361 ggactcggcc gcaatatttc aggtgaagct gtattggctg agttaaacaa gatgccccac 1701421 cttttggtcg caggcgcaac cggtagcggg aaaagtgtct gtgtcaacgg cattattaca 1701481 agtattttaa tgcgggcgaa accgcatgaa gtgaaaatga tgatgatcga tcctaaaatg 1701541 gtagagctaa atgtctacaa cgggattccg catttgcttg ctcctgttgt aaccgatccg 1701601 aaaaaagcgt cgcaggcttt gaaaaaggtt gtcaatgaaa tggagcggcg gtacgaatta 1701661 ttttctcata cgggtacaag aaatattgaa ggatacaatg attatataaa acgcgccaac 1701721 aatgaagaag gagcgaaaca gccagagctg ccttatattg ttgtcattgt ggacgagcta 1701781 gccgatctca tgatggtcgc ttcatctgat gtggaagatt cgattacgag attgtcccaa 1701841 atggcgcggg ctgccggcat ccatcttatt attgcgacac agcggccatc ggtggatgtt 1701901 atcacagggg tgatcaaagc gaacattccg tcacgaatcg cgttcagcgt atcttcacag 1701961 acggattcaa ggaccattct tgacatgggt ggcgctgaga agcttcttgg ccgcggcgat 1702021 atgctgtttt tacctgtagg ggctaacaaa cctgtccgtg tgcagggagc atttttgtcg 1702081 gatgacgaag tggagaaggt cgtcgaccat gtgattactc agcagaaagc gcaatatcaa 1702141 gaagaaatga ttcctgagga gacgacggaa actcattccg aggttactga tgaactttat 1702201 gatgaagctg ttgaattaat cgtcggcatg cagacggcat ctgtttcaat gctgcaaaga 1702261 agattcagaa ttggctatac gagagcggcg cgcctgattg acgcaatgga ggaacgcggt 1702321 gttgtcggac cgtatgaagg cagcaaacct agggaagtat tattatcaaa agagaaatat 1702381 gatgagctct cttcttaatg aagggagttc cgctttctat agttgtcaat aatgatatta 1702441 tgtaaactga tcacctttct atttattttt tcgacaaaac atgatatagt tgtcccaatt 1702501 gttcaataat ttttatcgaa agtggtttac ggaggggaaa catgtctaca aaagctgata 1702561 atcggcactt gtatttgaaa gtaattgaac gaattaaaga ggatataaaa aatgggatct 1702621 acactgagaa ggaaaagctg ccttctgaat ttgagctttc caaaaagctt ggtgtcagca 1702681 gagcgacgct aagagaagcc ttgcggatac tggaagaaga gcatgtgatt atcagaaggc 1702741 atggtgtagg cacttttgtc cattctaagc cgttatttct ttcgggtatt gaacagctga 1702801 acagtgtaac caagatgata gaacaggcga atatgacccc tggcacgatt tttctatcat 1702861 cacaagtgct tatgccgtct gaagatgata cgaagagatt tcacttggca gaagggcaag 1702921 aactttttta ccttgaacga gtcaggacag ctgacggaca gccgattgtg tattgtatag 1702981 acaaaattcc gatgaatatt ttgccgaatt ctttttctca tcagcaagaa tctatgtttg 1703041 acctgctaga gaaaaattca ggctccgtaa tcagctatgc agtaactgat atagaaccga 1703101 tcggctatca cgataccatt tctccagtgc ttgaatgcga tccggaaaca gctcttttgc 1703161 tgttaaaaca aacccattac gatcagcacg ataaaccggt gctttattct ttaaattatt 1703221 ttagagcgga taaattcaga tttcatgttt tgcgtaaacg attctaaaaa cggacgcctg 1703281 tatgtgtctg tttttttatt tgcactgatt catgtttctt tgtacatact ttcattccgg 1703341 ttaacgcaat atataaggga tgacaagaaa gtgaatgggt gaaaatgttg agagagaaaa 1703401 atggaatgaa aaatattatt gcattgtctt ctgtcccgct tgtgatgaca ctcgggaact 1703461 ccatgctgat tcctgttctt ccgatgatgg agaaaaagct gtctgtgact tcatttcaag 1703521 tatctttaat cattactgta tattcagtag tagcaattat ttgcattccg attgccggat 1703581 atttgtcgga tcgtttcggg agaaaaaaaa tattgcttcc atgcctcctc attgcaggat 1703641 tggggggagc cgtagctgct tttgcctcga cctatatgaa aaatccttat gctatgatct 1703701 tggcggggcg ggttcttcaa ggcattggtt ctgcaggtgc cgctccgatt gtcatgccgt 1703761 ttatcggcga cctgtttaaa ggagacgatg aaaaggtcag cgcgggtctt ggcgatattg 1703821 aaaccgccaa cacgtcaggg aaggtactga gtcccatact tggagcctta ctggcttctt 1703881 ggtattggtt tgtaccgttt tggtttattc cgtttttctg tttgatcagc tttttgctcg 1703941 tattgttttt ggtggccaag cctgaagaag atgaagatgc gcctgctgtt tctgagttta 1704001 ttaagagtgt gaagaaaatt tttaaacagg atggtcgctg gctttatacg gtcttcatta 1704061 tcgggtgtgt cattatgttt ttgttatttg gcgtattatt ttatttatca gatacgctgg 1704121 agaacaagta tgctattgac ggagtagcta aaggcggatt actggcaatc ccacttttgt 1704181 ttttgtcaac cagttctttt atagctggca aaaagatcgg taaagataaa ggccgaatga 1704241 aattttgcgt tgttacagga atgattctgt taaccctttc gtttattgcc ttgtggtgga 1704301 accacagttt ttatttttta tttgtctttt taagctttgg cgggattggg attggaatgg 1704361 ctcttcctgc tttagatgca ttgataaccg aagggattga aagtgaacaa tgcggaacca 1704421 tttcctcctt ttacaatagc atgcgcttta taggagtagc tctcggtcca cctgtttttg 1704481 ctgcattaat gtctaatgca aactggatta ttttcatact ctcggcgttt tgcagcatcg 1704541 tttctttatt tttagtgctc tttactgtag atgctaaaaa aagtgaagaa gaaaaaaact 1704601 tagggacggt ctagccagcc gtcttttttt gcgctttctt gcacagttta caactgtacc 1704661 tatacagcat gcggaggtta ttgtttcctt ataaatccta cagttgctat aattacatga 1704721 aagagtgttt ctgcggatgc tgaaaattgg tcataataca tactaattaa gaaatgaacg 1704781 aaggaggttc catatgtcat atgttaatga actcaaatca aagcacggcg gtttaaccgc 1704841 acacattgta aaaacagaaa aattcaaaac cgtctcgctt atttttaaga tgcttgcgcc 1704901 gctgacaaag gatcaagtca ccaaaagagc gcttctcccg catgtgcttc ttcgcggaac 1704961 gaaaagccat ccgaaaaccg caggattgcg ttcatacttg gatgagctgt acggcacgtc 1705021 agtatcggct gatcttacga aaaaaggaga gcggcatgtc attacgttca ggcttgaaat 1705081 cccgaatgaa aaatatttaa aagaccaaac gccgcttctc gagaaagggc tccagcttct 1705141 cgcagaactc gtcttttcac ctgctttgga gggagacgct tttcagtcac aatatgtggc 1705201 tcaagaaaaa cggacgctta agcaaagaat ccaagccgtc tatgatgata aaatgcgtta 1705261 ttcgaattta aggctgatac aggaaatgtg caaaaatgat ccttacgcgc ttcatgtcaa 1705321 tggtgaaatc gacgatgtcg atgacattac ggcagagcaa ttatacgaaa cataccaaag 1705381 cgctatccaa aaagaccagc ttgatctata tgttgttggc gacgtggaca gtaaccaggt 1705441 acaatcggca attgataagt atttcaaaac agaagagcgc actcttggca tgattgaaaa 1705501 caatcacgct gatgaaaaag ttcagccaaa agaagtaatt gatgaagagg atgtcaagca 1705561 aggaaaactg aatatcggct accgcaccag catcacttat acagatcagg attatcctgc 1705621 tttacaagtg tttaacggat tgttcggcgg attctctcat tctaaacttt tcattaatgt 1705681 tcgggaaaaa gccagtcttg cttactacgc ggcttcgcgt atagaaagtt ttaaaggctt 1705741 gttaatggtg atgtcaggca ttgaagtgaa aaattttgaa caggcggttt cgattattgc 1705801 tgagcaattc caggcaatga aaaatggcga tttcagtgag caggatatag cacagacaaa 1705861 ggccgttatt cgaaatcaag tgctggaaac gattgataca gcatacggtt tatctgagtt 1705921 tttatatcag caggccgctg ctcaagtcga gattcctatc gaagactttc ttgccaatat 1705981 tgagaatgtc acaaaagagg atatcattaa agccggcgaa aagattcagc ttgatacgac 1706041 ttatttctta aaagggacgg agggtgcatc ttgatcaaac caatcgaata tgaacagctt 1706101 caggagacgc tgtatcatga aaaaatgtcc aacggccttg atgtttacgt tttgccgaaa 1706161 aaaggcttca acaagacata tgcggtcttt acaacaaagt acggctcgat agataaccgg 1706221 tttgtccctt taggtaaaaa cgagatggtt cacgtgccgg acgggattgc tcactttctt 1706281 gagcacaagc tgtttgagaa agcggacgga gacgtttttc aagatttcag caaacagggg 1706341 gcttctgcca atgcgtttac gtcatttaca agaacggctt accttttctc aagcacatca 1706401 aatgttgaac gcaatttaga gacgcttatc gatttcgtac aggacccata ttttactgaa 1706461 aaaacggttg aaaaggaaaa agggattatc gggcaggaga ttaatatgta cgacgataac 1706521 cctgattgga ggctttactt cggggtcatt gaaaacatgt acaaagagca tcctgtcaga 1706581 attgacatag cgggaacagt ggaaagcatt tcacatatta caaaagacct tctttatgaa 1706641 tgctatgaaa cgttttatca cccgagtaac atgctccttt tcattgtcgg ccctgtagat 1706701 cctgaagcga ttatttctca ggtaagagaa aaccagggga aaaagccgta tactgatcag 1706761 ccggagatca aacgagaaga agtgaaagag caagaagcgg ttttccgaaa agaaaaagag 1706821 atcaaaatga acgtgcaggg accgaaatgc cttgttgggc tgaaatccaa aaatccgttt 1706881 aaattaggca aagagctctt aaagcatgaa ctttcaatga acttattgct tgaagctctt 1706941 tttggcaaaa gctctgccca gtatgaatca ctttatgaaa aaggatatat tgacgaaacg 1707001 ttcagctttg attttactgc tgaatatggg ttcggttttg cggcgatcgg cggagatacg 1707061 cctgagcctg atcaattggc tgaagacatt tcaagcatgc ttttgcgcgc cggtgaactg 1707121 attactgctg aaaagattga acttgccaga aagaaaaaga tcggcacatt cttaaaagcg 1707181 ctgaattccc ctgaatacat cgccaatcaa tttacccgtt atgcgttctt ggatatgagc 1707241 ctgtttgatg ttgtaacggt actcgagcag attaccctcg aggatgtcca gaacgtaata 1707301 caagaggaaa tcgctgcaga cagactgact gtctgcaagg ttgttcctaa atcataaaca 1707361 aaacatccct ccagtgtgag gggtgttttt ctgcggaaag aaggaaagag gatgaacaaa 1707421 acagcactaa tcaccggagc aagcggcggc attggcaaaa gcatcagcga aacccttgca 1707481 gctagaggat acaatctgct gctgcattac aatacaaatc aaaacgcggc agcggagctt 1707541 gctgaaaaac taagtcagat gtttggcgta aatgcggaga tattacaagc tgacctgtcc 1707601 gcgcaagatg gagcagataa gctgacaagt tcaattgttc agccgattga tgcgattgtt 1707661 ttaaacagcg gacgaagcca ttttgggctg attacggatg tagataacgc aacggtccag 1707721 gaaatggttc agcttcatgt ggcgagtccg tatatgctga cgagaaacct tctgccaggc 1707781 atgattcgga ataaatcggg agcgattgtg gctgtcagct cgatttgggg agagactgga 1707841 gcatcctgtg aagtgttgta cagcatggca aaaggagctc agcattcatt tgtaaaagga 1707901 ttggctaagg agctggcgcc aagcggaatc agagtaaacg ccgtagcgcc gggtgcagtt 1707961 gatacaaata tgatgaatca atttaccccg gctgaaaaag aagagatcgc tgatgagatt 1708021 ccgatcggcc ggctggcccg gccgcaagaa attgcggatg caacagcttt tctcctgtct 1708081 gaaaaagcgt catatatcac cggccaaatt ctgtcggtga atggcggctg gcactgctga 1708141 tccgaaaata ttcggtgtat agtttctttt gcgaaggaca caataatctt gtaacttcac 1708201 atgaaatgga ggaaacaagc atgtcagtat tagaaaactg ggatagctgg aaaaacttcc 1708261 ttggcgaccg tctgaactat gcgcaagata aaggtatgag ccaggatacg attacagatc 1708321 ttgcgacaga aatcggcagc tacttggcta atgaagtgga atctaagaac gagcaggaaa 1708381 aagtgctggc agatctttgg agtgtagcat caaaagatga acagcacgcc attgccaata 1708441 tgatggttaa gcttgttgaa aataacagca ctcactagga agagagggga tttttcctct 1708501 cttttttatg ttttcctcat cacagcaaca ttcttctttc taattagaga aaaatgcttt 1708561 atgataaagg aaggtaaaat tttgccacaa tgaagggggt atatcatttg gcaaagctcg 1708621 aatggtattt tgaatatgaa attcaagtga accgccccgg actgctcggg gatatttcat 1708681 ctcttcttgg gatgctttct atcaacatcg taacgataaa cggcgtcgat ctttccagaa 1708741 ggggaatgct cctcaggtgc cgccatatag atcaaattaa acgattagaa tcaatcttaa 1708801 aaacgatgga aacaattaaa gtaacgaagc ttagagaacc gaggcttcgc gaccgtcttg 1708861 ccgtacgcca cggccgttat attcaacggg atgccgatga caagaaaacg ttccgctttg 1708921 aacgggacga gcttggctta ttagtcgatt ttatggccga attgttcaaa aaagaaggcc 1708981 ataaattaat cggaatcaga ggtatgccgc gtgtcgggaa aacggaatcg attgtagcct 1709041 ctagtgtgtg cgagcaaaag gtggctgttt gtgtcatcaa ccttgctgaa gcagacgata 1709101 agaagccagc tgattgccga tgaatacagc actgaaaatg tctttatcgt tgacggaatt 1709161 gtgtcaacac gaagagggtc agaacgccat ctccagctgg tccgagaaat catgcggctg 1709221 cctgcaacaa aagtggtgga gcatccggac atattcgttc aaaatacaga gtatacacta 1709281 gatgactttg attatattat tgaactgaga aatgaccctg atgaggttat tacatatgaa 1709341 catgccgagg aaccccaaat gtttgatcaa tccgggtttt caagctttga tttttaaaat 1709401 tggaaggtgt ttgttgtgac tgaactagga atccggctca aagaagccag agaggaaaaa 1709461 gcaatgtcat tggatgatct ccaagcggca acaaagattc aaaaaaggta tttaaccgcc 1709521 ttggaggaag gaaactatga cattattccg gggaagtttt atgttcgggc attcatcaag 1709581 caatatgcag aagccgttgg gcttgatgcg gatcagctgt ttgaggagca taaaaaagat 1709641 atccctaata cgtatcatga tgatgtgtct gaaaagatct ccggcatgaa tcttcaaaag 1709701 gaaatgccaa agccagcatc taaggcgctg gagctgctgc caacaatact tgttattctc 1709761 ggcgtgattg tcgtgattgc cattgtgtac gcgatcattc aatttgccaa tcacaaaaac 1709821 agtgatgatc acaatgcggc atcagaaaaa gcaattacgc aaagtgagag caagtacgaa 1709881 atccctaaag attcaacgct gaaagagaat caaaataaca gctctgaaaa agagacagac 1709941 actaaaaaag aaacgaaaga aaacgaagat aagaaaaaag aaaatgacag tgagaagctg 1710001 gagattaaag ctgctggcac tgaaggatcg ttaacgactt atgaagtgtc cggcgctgat 1710061 aaaatcgagc tggaactgaa ggcatcagac agctcctgga ttagagtgcg cgatgaaaac 1710121 agcagctctt taaaagaagg aacgctgaaa aaagacgaaa cctataaaaa agacataact 1710181 gatcagaaac aagttgatat ccgcaccgga tatgcaccta atctgaaaat aaaaatcaac 1710241 ggtaaggttc tttcatatga acttgatccg aaaaaagtga tggcacaaac cataaagatt 1710301 gtaaataaaa aggaagaaaa gtcatcttaa ttaccagatg acttttcttc acgtccgagt 1710361 atgaaattgg aggggcttta tgtttaactt accaaataaa atcacactag ctagaatcgc 1710421 attaatccca atcttcatga ttatcatgct ggcgccgttt gactggggca ggctcgaagt 1710481 tggagacgaa tccatcccgg tcgcacattt ggcgggggcc attctattta ttattgcatc 1710541 tacaacagac tgggtggacg ggtattatgc ccgaaaatta aatctcgtaa caaacttcgg 1710601 gaaatttctt gatccgcttg cggacaaact gctcgtatcc gcagcgttaa ttatccttgt 1710661 tcaatttgat ctcgctccag cttggatggt cattgtgatt atcagcaggg agtttgccgt 1710721 gacaggttta aggcttgtct tagccggaac aggagaagtc gtagctgcta acatgcttgg 1710781 taaaatcaaa acctgggcac agattattgc ggtatctgca ttgcttcttc ataatcttcc 1710841 atttgaactt gtgtcattcc cgtttgcaga cttggcgctg tgggtagccg tcttctttac 1710901 tgtcgtctca ggctgggaat atttctctaa aaattgggaa gcgttaaaaa catctaacta 1710961 agaaagaagg acttcgtcat ggaatttcca aaaaaagcag aaataattgc agtcggttca 1711021 gagttgctgc ttggtcaaat cgccaataca aatgctcaat ttatcagcaa acagctcgct 1711081 gaaatcgggg tcaacgtatt ttatcataca gcggtcggag ataacccgga gcggctgaag 1711141 caggtcatcc gcattgctga agaacgctct gacttcatta ttttttcagg agggcttgga 1711201 cccacaaaag atgatctgac gaaagaaacg attgcaaata cgctgggacg tccgcttgtg 1711261 ttaaatgatg aggcattcca atccattgag gactatttca aacgaacaaa acgcacgatg 1711321 tcacctaata accgaaaaca ggcgcttgtg atcgaaggct ctgacgtgct ggcgaatcac 1711381 tttggaatgg ccccgggaat gctcacagag catgaatcgc gctattatat gcttcttcct 1711441 ggaccgccga gcgaattgcg tccaatgttt gaaaacgagg caaagcctct tctgctgaaa 1711501 aagatgggtt caaatgaaaa aattgtgtca actgttcttc gctttttcgg tatcggtgaa 1711561 tctcagcttg aagccgattt ggaagatatt attgatgcac aaaccaatcc gacaattgcg 1711621 cctttggcgg ctgatggaga ggtgacgctg cgtctgacag ccaaacacgc cgatgaaaag 1711681 gaaacagagc gtctgttaaa agaaacagag gccgttatct tagagcgtgt cggtgaattt 1711741 ttctatggtt acgatgatac ttctcttgta aaagagctat ctatagcatg taaggaaaaa 1711801 ggcataacaa tttctgcggc agaaagcttt accggagggc tgttttctga atggctgacg 1711861 gatcatagcg gtgcctcaaa attatttgcc gggggcgttg tttgctatac aaacgacgtg 1711921 aagcagaatg tgcttggtgt caagaaggaa acattagatc gttttggggc ggtcagcaag 1711981 gagtgcgcat ccgaactggc taagggtgtt caaaaactca ctggcagcga tatcggcatt 1712041 agctttactg gtgtagcagg acctgatgct caagaagggc atgagcctgg gcatgtgttt 1712101 atcggcattt ccgcaaatgg taaagaagag gttcacgagt ttcactttgc gggctccaga 1712161 acggggatca gaaaacgcgg cgctaaatac ggctgccatt taatcttaaa gcttttagag 1712221 caaaaataat attttcagca cattatcctc ctaagaaaac atgatttctc tgatacatta 1712281 tgatattttg ataggaatca cgccaagaaa aaatccgaat atgcgttcgc ttttttcttg 1712341 gcaaatccct tcaaacaggg tatagtatat gtagtggtaa cataaaggag gaaaaaatag 1712401 aatgagtgat cgtcaggcag ccttagatat ggctcttaaa caaatagaaa aacagttcgg 1712461 caaaggttcc attatgaaac tgggagaaaa gacagataca agaatttcta ctgtaccaag 1712521 cggctccctc gctcttgata cagcactggg aattggcgga tatcctcgcg gacggattat 1712581 tgaagtatac ggtcctgaaa gctcaggtaa aacaactgtg gcgcttcatg cgattgctga 1712641 agttcagcag cagggcggac aagccgcgtt tatcgatgcg gagcatgcgt tagatccggt 1712701 atacgcgcaa aagctcggtg ttaacatcga agagctttta ctgtctcagc ctgacacagg 1712761 cgagcaggcg cttgaaattg cggaagcatt ggttcgaagc ggggcagttg acattgtcgt 1712821 tgtcgactct gtagccgctc tcgttccgaa agcggaaatt gaaggcgaca tgggagattc 1712881 gcatgtcggt ttacaagcac gcttaatgtc tcaagcgctt cgtaagcttt caggggccat 1712941 taacaaatcg aagacaatcg cgattttcat taaccaaatt cgtgaaaaag tcggtgttat 1713001 gttcgggaac ccggaaacaa cacctggcgg ccgtgcgttg aaattctatt cttccgtgcg 1713061 tcttgaagtg cgccgtgctg aacagctgaa acaaggcaac gacgtaatgg ggaacaaaac 1713121 gaaaatcaaa gtcgtgaaaa acaaggtggc tccgccgttc cgtacagccg aggttgacat 1713181 tatgtacgga gaaggcattt caaaagaagg cgaaatcatt gatctaggaa ctgaacttga 1713241 tatcgtgcaa aaaagcggtt catggtactc ttatgaagaa gagcgtcttg gccaaggccg 1713301 tgaaaatgca aaacaattcc tgaaagaaaa taaagatatc atgctgatga tccaggagca 1713361 aattcgcgaa cattacggct tggataataa cggagtagtg cagcagcaag ctgaagagac 1713421 acaagaagaa ctcgaatttg aagaataaaa ataaaataag tttcaaatga tacaaaaggc 1713481 tgagtgaaaa actcagcttt tttgtatttt gcaaaaaaat gataaaaata ttgctttttt 1713541 tgacaacttt tttagggctt tattcgtcta acaaaacgtg tgcaaaatgg aatttatttt 1713601 gggaggaaaa aatgaatgac aagcccaacc cgcagaagaa ctgcgaaacg cagacggaga 1713661 aaactaaata aaagaggaaa actgttgttt ggtcttttag cagtgatggt ttgcattacg 1713721 atttggaatg ctcttcatcg aaatagtgaa gaaaacgaac catctcaaga aactgcagcg 1713781 gtttcaaata ccgatcagaa aaaagaggtc aaaaagaaaa ctgccaaaaa atcagaggaa 1713841 caaatcaaaa cagtggatcg aaaccaaaaa atcagcaatt atttaaaaga gatcggtttc 1713901 agcggaacag ccatgattgt cagaaatgga gaaatcgtaa caaataaagg ttttggctat 1713961 gctgaccgta aacactacat tcaaaataat ccattgacat ctttttatgt cggttcatca 1714021 caaaaagcgc tgattgcaac tgctattttg cagcttgagg aaaaggggaa acttcagaca 1714081 agtgatccgg taagcacgta tttacctcat tttcccaacg gacaaacgat tactttgaag 1714141 aatctgctta cacatacatc ggggataaac ggacatattg aaggaaacgg cgccattact 1714201 ccggacgatt taataaaaga tatagaactt cagggaatca aacgtcagcc gggcgtatgg 1714261 gactacaagg attccaacta ttctgttctt gcttatatta ttgctgaagt aagcggtgag 1714321 ccctatgaac agtacataaa gaatcatatt tttaaacctg cgggaatgac gcatgcaggc 1714381 ttttacaaaa catatgaaaa agaaccttat cctgccgtcg ggtataagat ggagggcagc 1714441 aaaacagtta caccgtatat acctgattta tcccagctgt atggagcggg tgatatttat 1714501 atgagcgcta tagatatgta caaatttgac caagcgctga tagacggaaa actgtattcg 1714561 caaaaaagct atgaaaagat gtttacgcca gggagcagct ccacatacgg catgggattt 1714621 tatgttgctc ccggaagcta ttcaaaccat ggtgttatgc cgggcttcaa tatcttgaac 1714681 agctttagca aatctgggca aaccattgtt attttgttct caaacattca aaataatgct 1714741 aaattgggcc aagtgaacaa taaaatatac cagcttctaa atcaagaatg attggcgatc 1714801 ttcttttgga tgaattgcat tcggcacgtg aaaagaagac tggcctgcaa acgttaagat 1714861 ggcaagcttg acaagtattt ccgacacatt tacaatgaag ttgtaacatt tgttttttta 1714921 acatgattgt taaaccattt aaacttgaca agggcgatga acacactcat tccctgtgaa 1714981 ggttctgtat gttgagaaaa ctagacaatg tacatgccga cactttttaa gcaacaacca 1715041 agttcatagc aagaggaggt gaaagtatga ccccaattat gatggttctc atctccattt 1715101 tgctgattct actcggttta gttgttggct actttgttcg taaaaccatt gccgaagcga 1715161 aaattgcggg cgcacgcggt gcagccgagc aaattcttga agatgcgaag cgtgatgctg 1715221 aagcactgaa aaaagaagct ctgcttgaag caaaggatga aatccacaaa cttcgaatag 1715281 atgctgaaca ggaagttcgt gaaagacgaa atgagcttca aaaacaagaa aaccgtttac 1715341 tccaaaagga ggaaaacctt gatcgcaaac atgagggaat tgataaacgg gaagcgatgt 1715401 tggagaagaa agatcattct ctgaatgaac gacaacaaca tattgaagag atggaaagca 1715461 aagtggatga gatgattcgt atgcagcagt ctgagttgga acgaatttcg agtctgactc 1715521 gtgacgaagc gaaacaaatc attcttgagc gggttgaaaa cgagctttca catgacatcg 1715581 ccatcatgac aaaagaaact gaaaaccgtg cgaaagaaga ggcggataag aaagcgaaaa 1715641 acattctttc actcgcctta cagcgctgcg cagcggacca cgttgccgaa acaacggtat 1715701 cagttgtcaa tcttccaaat gatgagatga aaggacgtat catcggacgg gaagggcgta 1715761 acattcgtac gcttgaaacg ctgacaggaa ttgacctgat tattgatgat acgcctgaag 1715821 ctgtcattct ttccggattt gatccgatca gacgtgagac agccagaatt gctcttgata 1715881 aactcgttca ggatggccgt attcatccgg cacggattga agaaatggtt gaaaaatctc 1715941 gccgcgaggt cgatgactat attcgtgaga tgggtgagca aacgacattt gaggttggcg 1716001 ttcatggcct ccacccagat ctcatcaaga tcctcggccg cttaaagttc cgtacaagct 1716061 acggtcaaaa tgtgcttaag cattccatgg aagtcgcatt cttggccggt ctaatggcat 1716121 cggagcttgg tgaagacgca aagcttgcta aacgtgcggg tcttcttcac gacatcggga 1716181 aagcaattga ccatgaagta gaaggaagcc acgttgagat cggggtagag cttgcgacca 1716241 aatataaaga gcacccagtc gtgattaaca gtattgcatc acaccacggg gacgaggagc 1716301 cgacttccat tattgctgta ctggtagctg cagcagatgc gctttccgct gcaagacctg 1716361 gcgcaagaag tgagacgctc gagaattata ttcgaagact tgaaaaactt gaagaaattt 1716421 ctgagtccta cgaaggtgtt gaaaaatcat ttgccattca ggctggacgc gaagtgcgaa 1716481 ttatggtgaa gccggattca attaatgatc ttgaggctca tcgactggcg cgagatatcc 1716541 gcaagcgaat tgaggacgag ctcgattatc caggtcatat taaggtgaca gtaatcagag 1716601 agactcgagc cgtagagtat gcaaaataaa gtgatgcgct aagcatcact ttattttttt 1716661 gacggcaagg aattttcaag aagaaaggat ttacaaaatg agaattttat ttatcggaga 1716721 tgttgtcggt tcaccgggcc gtgacatggt caaagaatat gtaccaaagc taaaaacaaa 1716781 atataagcct cactttacca ttattaatgg tgaaaacgcc gcacatggaa aaggcctgac 1716841 ggaaaaaatt tatcacagct taatccagtc cggcgcagat gcaatcacaa tggggaacca 1716901 cacatgggac aaaaaagaaa tatttgattt tatagatgac gttccgaact tggttcgccc 1716961 ggcaaacttt cctgaaggaa caccggggaa agggatcaca tatgtgaaag caaacggcaa 1717021 agaactagca gtcattaatt tgcagggacg tacgtttttg ccgccgcttg atgacccgtt 1717081 tttaaaagcg gatgaattga tcgcagaagc tgcgaaaaga acaccgtaca tttttattga 1717141 ctttcatgcc gaagcgacaa gtgaaaagct cgcacttggc tggtacacgg atggacgggc 1717201 atcggctgta gtaggaactc atacacacgt gcaaacagcg gataaccgca ttttgccgaa 1717261 gggaacggca tatattactg atgtgggaat gactggcccg tatgacggta tactggggat 1717321 ggacagagag acgattatta agcgattcaa aacgaacctt ccagtccggt ttactgtcgc 1717381 tgaaggaaaa acaacgctca gcggagttgt cattgacatt gacgatcaaa cgaaaaaagc 1717441 cgtgaaaatt gagcgtattt taatcaacga tgatcacatg ttctttgaat agttgaacat 1717501 atggttattt tataaaaata ttaaaaagaa aagcaggaat atagcaactc cttagtgaat 1717561 atagtaaaaa tggaaggtag cccgctattt ttgaaaagca ttgtggggat ggctttttgg 1717621 atagcaacat ctaataatga ttgttctaat gaacactcac ttatccattg taaaactaag 1717681 ggggagcaga aatggaaatc ttaaaagttt cagcaaaatc gagtccaaat tcagtggcag 1717741 gtgcgcttgc aggcgtgttg agagagcgag gagccgccga gattcaagcg atcggagcgg 1717801 gtgcattaaa ccaggctgta aaagctgtgg cgattgccag gggatttgtg gcgccaagcg 1717861 gcgttgattt gatttgtatt ccggctttta cagatattca aatcgatggg gaagaaagaa 1717921 cagcgattaa attaatcgtg gagcctcgct aaaaacaaat aaagcattct caacctgttt 1717981 gcgtaatgca aacaggttgt ttttcattta ttgtgatatt ttctcccgat agtattttta 1718041 gcacataaat gagcgaatat acaaaatcag aaatgagcta aaacgtttca aaaaaaattt 1718101 ccgcccattt ttcaagacag atacttttgt ccttctggaa aagacagttc tgtttacgct 1718161 tattccatat catggtacaa tccgaatata acaagaattt ttcaaggagg attgtacatg 1718221 cagagtggaa agatgaaagc tctaatgaaa aaggacgggg cgttcggtgc tgtgctgact 1718281 gaagttccca ttcctgagat tgataaacat gaagtcctca taaaagtgaa agccgcttcc 1718341 atatgcggca cggatgtcca catttataat tgggatcaat gggcacgtca gagaatcaaa 1718401 acaccctatg ttttcggcca tgagttcagc ggcatcgtag agggcgtggg agagaatgtc 1718461 agcagtgtaa aagtgggaga gtatgtgtct gcggaaacac acattgtctg tggtgaatgt 1718521 gtcccttgcc taacaggaaa atctcatgtg tgtaccaata ctgctataat cggagtggac 1718581 acggcaggct gttttgcgga gtatgtaaaa gttccagctg ataacatttg gagaaatccc 1718641 gctgatatgg acccgtcgat tgcttccatt caagagcctt taggaaatgc agttcatacc 1718701 gtactcgaga gccagcctgc aggaggaacg actgcagtca ttggatgcgg accgattggt 1718761 cttatggctg ttgcggttgc aaaagcagca ggagcttctc aggtgatagc gattgataag 1718821 aatgaataca ggctgaggct tgcaaaacaa atgggagcga cttgtactgt ttctattgaa 1718881 aaagaagacc cgctcaaaat tgtaagcgct ttaacgagtg gagaaggagc agatcttgtt 1718941 tgtgagatgt cgggccatcc ctcagcgatt gcccaaggtc ttgcgatggc tgcgaatggc 1719001 ggaagatttc atattctcag cttgccggaa catccggtga caattgattt gacgaataaa 1719061 gtggtattta aagggcttac catccaagga atcacaggaa gaaaaatgtt ttcaacatgg 1719121 cgccaggtgt ctcagttgat cagttcaaac atgatcgatc ttgcacctgt tattacccat 1719181 cagtttccat tagaggagtt tgaaaaaggt ttcgaactga tgagaagcgg gcagtgcgga 1719241 aaagtaattt taattccata aagggggata aacatgacga aggaatttga gtttttaaaa 1719301 gcagagctta atagtatgaa agaaaaccat acatggcaag acataaaaca gcttgaatct 1719361 atgcagggcc catctgtcac agtgaatcac caaaaagtca ttcagctatc ttctaataat 1719421 tacctcggat tcacttcaca tcctagactc atcaacgccg cacaggaggc cgttcagcag 1719481 tatggagccg gcaccggatc agtgagaacg attgcgggta catttacaat gcatcaagag 1719541 cttgagaaaa agctggcagc ctttaaaaaa acggaggcgg cacttgtatt ccaatcaggc 1719601 ttcacaacaa accaaggcgt actttcaagt attctatcaa aagaggacat tgtcatctca 1719661 gatgaattga accatgcctc tattattgac ggaattcgac tgacaaaggc ggataaaaag 1719721 gtgtatcagc acgtcaatat gagtgattta gagcgggtgc tgagaaagtc aatgaattat 1719781 cggatgcgtc tgattgtgac agacggcgta ttttccatgg atggcaacat agctcctctg 1719841 cctgatattg tagagctcgc tgagaaatat gacgcatttg tgatggtgga tgacgcccat 1719901 gcatccggag tacttggcga aaacggcagg ggaacggtga atcacttcgg tcttgacggc 1719961 agagtgcata ttcaggtcgg aacattaagc aaggcaatcg gagtgctcgg cggctacgct 1720021 gcaggttcaa aggtgctgat cgattatttg cgccataaag gccgtccatt tttattcagc 1720081 acatctcatc cgccggcagt cactgcagct tgtatggaag cgattgatgt cttgcttgaa 1720141 gagccggagc atatggagcg cttgtgggag aatactgcct attttaaagc aatgcttgtg 1720201 aaaatgggtc tgactctcac gaagagtgaa acgccgattc ttcctatttt aataggtgat 1720261 gaaggtgtgg caaagcaatt ttcagatcag ctcctttctc gcggtgtttt tgcccaaagt 1720321 atcgttttcc cgactgtagc aaagggaaaa gccagaattc gcacgattat aacagcagag 1720381 cacaccaaag atgaactgga tcaggcgctt gatgtcatcg aaaagacggc aaaggagctc 1720441 cagctattgt aacaagagga agagtttact cttcctcttt tgattcctta ttgattatta 1720501 ttctcaatga gtgtacaatg ataggttgcc agttgtgcag agcttcaata acctttatac 1720561 tgaagggtgg aagtttggtt tgaaaggaga aaatatgaca tgaatgaaaa acaaaaatta 1720621 gagagcggac aagttcatcc atcggacaaa aaatccgaga aggattacag caagtacttt 1720681 gaagctgttt acattccgcc ttctttaaaa gacgcgaaaa aacgaggcaa ggaagccgtt 1720741 acttatcata atgactttaa aatttctgaa caatttaaag gattgggaga cggaagaaag 1720801 ttctatatcc gtacgtacgg ctgccaaatg aatgaacacg atacagaggt tatggcaggg 1720861 atctttatgg cgctcggtta cgaagcgaca aactctgttg acgatgccaa tgtcattttg 1720921 ttaaatacat gtgcaatccg tgaaaatgct gaaaacaagg tgtttggtga gctcgggcac 1720981 ttaaaagcac tgaaaaaaaa caatcccgat ctgattttag gcgtgtgcgg ctgtatgtcc 1721041 caagaggaat cagtcgtgaa ccgtattttg aaaaaacatc cgtttgtcga tatgattttc 1721101 ggaacgcata acattcatcg cctgccggag cttttgtcag aagcatacct ttcaaaagaa 1721161 atggttgtag aagtttggtc taaggaaggg gacgttattg aaaaccttcc aaaagtccga 1721221 aatggaaaaa ttaagggctg ggtcaatatc atgtacggct gtgacaaatt ctgtacgtat 1721281 tgcattgtgc cttacacacg cggaaaagaa agaagccgcc gccctgagga tatcattcag 1721341 gaagtgagaa ggctcgcaag tgaaggctat aaggaaatta ctctgttagg ccaaaacgta 1721401 aacgcgtatg gaaaagactt tgaagatatg acgtacggac ttggtgattt gatggatgaa 1721461 ctgagaaaaa tcgatatccc gagaatccgt tttacaacga gtcatccgcg cgactttgac 1721521 gaccgcctca ttgaagtgct ggcaaaaggc ggaaatctgc ttgatcacat tcatcttccg 1721581 gttcaatcag gaagctcaga agttctcaag ctgatggccc gcaaatatga cagagagcgt 1721641 tacatggagc tggtgcgaaa aattaaagaa gcaatgccaa acgcttcttt gacaacggac 1721701 attatcgtcg gatttccaaa tgaaacggac gaacagtttg aagaaacgct ttctctatac 1721761 cgtgaagtgg agtttgacag cgcctatacg ttcatttact ctccgcgtga aggcactccg 1721821 gctgctaaga tgaaagataa tgtaccgatg cgtgtgaaaa aagaacgcct gcagcgtcta 1721881 aacgcactgg tgaatgaaat ttctgctaaa aaaatgaagg aatacgaagg caaggttgtc 1721941 gaagtattag ttgagggtga aagcaaaaat aaccctgata ttcttgctgg ctatactgaa 1722001 aaaagcaagc ttgtcaattt caaagggccg aaggaagcca tcggcaaaat cgtccgcgtg 1722061 aaaatccagc aagcgaaaac atggtcgctt gacggagaaa tggtaggaga agcaatcgag 1722121 gtgaaatgag atgacgctct actcaaaaaa agacattgtg cagcaggctc gaaaccttgc 1722181 aaaaatgatt tctgaaacag aagaggttga ttttttcaaa cgggctgaag cgcaaatcaa 1722241 tgagaatgac aaagtgtcca caatcgttaa tcagattaaa gccctgcaaa agcaggctgt 1722301 caatctgaag cattatgaaa agcatgaagc gctcaaacaa gtagaagcaa aaattgacgc 1722361 gctgcaagaa gagcttgaag agattcctgt tatccaggaa ttcagagact cgcaaatgga 1722421 agtaaatgac ctactgcagc tcgttgcaca caccatttcc aaccaagtca caaatgaaat 1722481 catcacatca accggaggcg acctgctgaa aggggaaacc ggttcaaagg tgaagcattc 1722541 aaataacagc tgttctctct aaacacggtg cctttacagg cccgtgtttt tttatcattt 1722601 gtgcggttaa aaatgaacta aataatctat gtaccaaatg ttcaattggt ttttctgtgc 1722661 tcagccgcgt ataaacttta tcgcacttat aagtaaagtt tctaggcacc cctgcataca 1722721 atggaacaga aactttgtat ttttatattt tatttataaa aatgcacact agacaaatgc 1722781 ccagcataag ataacacgaa gaagaacaag gaggcatgcc ggaatgtctg aatacaggga 1722841 aattattacg aaggcagtag tagcgaaagg ccgaaaattc acccaatgca ccaacaccat 1722901 ctcgcctgag aaaaaaccga gcagcatttt gggtggttgg attattaacc acaagtatga 1722961 cgctgaaaaa attggaaaaa cggtagaaat tgaagggtat tatgatataa acgtatggta 1723021 ctcttacgcg gacaacacaa agacagaggt tgtcacagaa cgggtaaaat atgtagatgt 1723081 cattaaactc agatacagag acaataatta cttagatgat gagcatgaag tgattgccaa 1723141 agtgcttcag cagccaaact gccttgaagt gaccatttcg ccgaatggaa ataaaatcgt 1723201 tgtgcaggca gaaagagaat ttttggcgga agtggtaggg gaaacaaagg tagttgttga 1723261 ggtcaatcct gactgggaag aggatgacga ggaagattgg gaagatgagc ttgatgaaga 1723321 gcttgaagac atcaacccgg agtttttagt gggagatcct gaagaataaa aaagggacta 1723381 ggggagacag tacccccaag tctctttttt atattgatat atcattcttt tatcactttt 1723441 tgtttatgtt ataatgaagg ttggaaaata gaaacgttga tacatagtga gggattaaac 1723501 aatggccggt tatacgccta tgatacagca atatttaaaa ataaaggcag agcaccagga 1723561 tgccttttta ttttttcgcc tgggtgattt ttatgaaatg ttttttgagg acgccaaaaa 1723621 agcgtcacaa gagctggaaa ttacgttaac gagcagagac ggcggtgcgg ctgaaaaaat 1723681 accgatgtgc ggtgtgccgt atcattctgc ttccgcgtat atcgaacagc ttattaaaaa 1723741 aggatacaaa gtggcgatct gtgaacagac ggaagatccg aaagccgcaa agggcgttgt 1723801 gaaaagagaa gtagttcagc tgattacgcc cggaactgta atggacggca aaggcatcca 1723861 tgagtcggaa aataatttta tcgcatctgt ttcagcctgc tcgaacggat acggacttgc 1723921 tctgtctgat ttaacaacgg gagaaaattt ggctgttttg attgaacggc ttgaagacgt 1723981 catatcagaa atttattcag tcggcgcacg ggaaatcgtg gtttcaggaa gcttggatgc 1724041 cgatacagtg gcacagctga gagagcggtg cggtgcaacg atttcaattg aagacggaga 1724101 aacagacgaa cacgtaacga tcattgagca cttaaataat gaagatataa caaaaacatt 1724161 tctgcgctta tatacgtatt tgaaaagaac ccaaaagcgc agccttgatc atcttcagcc 1724221 cgtgcaggtg tatgagcttg aggaagcgat gaaaattgac ttgtactcaa agcgtaatct 1724281 ggagctgacc gaaacgattc gttcgaaaaa taaaaaaggc tcccttttgt ggctgctgga 1724341 tgaaacaaaa acggcaatgg gaggccggct acttaaacag tggattgacc ggccgcttat 1724401 cagagtcaat caaatcgaag agcgccaaga aatggtggaa acattaatgt cccatttctt 1724461 tgaacgggaa gatctgcgtg aacgtttaaa agaagtatat gacttagaac gccttgccgg 1724521 ccgcgttgca ttcggaaatg tcaatgcccg ggatttgatt cagctgaagg aatcgttaaa 1724581 gcaagtgcct ggcatcaaac agctggttgc ttcactggct catgacaagg ccaaggaacg 1724641 tgcaaagcgc attgaccctt gcggggatgt acttgaactg ctggaagaag cgctgtacga 1724701 aaaccctcct ttatcggtaa aagaagggaa cctgattaaa gatggttata atcaaaagct 1724761 tgatgaatat cgtgatgcaa gcagaaacgg aaaagactgg attgcccgcc tggaacagca 1724821 ggagcgggaa tacacaggca ttcgctcttt aaaggtcggc tttaataaag ttttcggtta 1724881 ttacattgaa gtgacaaaag caaacttgca tttgcttgag gaagggcgtt atgagcggaa 1724941 gcagacgtta accaatgcag agcgctacat tacacctgaa ttaaaagaaa aagaagcgct 1725001 cattttagag gcggaaaata acatctgtga gctggagtac gagctgttta ccgagctgcg 1725061 cgagaaagtg aagcagtata ttccgcggct gcagcagctt gcaaaacaga tgagcgagct 1725121 ggacgcactg caatgctttg cgacaatcag tgaaaatcgc cactacacga aaccagagtt 1725181 ctctaaagat gaagtcgaag tgattgaagg cagacacccg gttgttgaaa aagtcatgga 1725241 cagccaggaa tatgtcccga acaactgtat gatgggcgat aacagacaaa tgcttctcat 1725301 tacaggtcca aacatgtcag ggaaaagcac gtatatgaga caaatcgcgc tcatttccat 1725361 tatggcgcaa atcggctgct ttgtacccgc gaaaaaagcg gtgctcccga ttttcgatca 1725421 aatttttacg cgaatcggcg ctgcagatga tttgatttcc ggacaaagta catttatggt 1725481 agaaatgctt gaagcgaaaa atgcgattgt caatgcgacg aaaaacagcc tcattctgtt 1725541 tgatgaaatc gggcggggaa cgtccactta tgacggcatg gcgctggcac aggcgattat 1725601 tgaatatgtt cacgatcata tcggcgccaa gacgctgttc agcacacact atcacgagct 1725661 gaccgttctt gaggacaagc tgccccagct gaaaaacgtt catgttcgcg ctgaagaata 1725721 taacggaacg gttgtctttc ttcatcaaat taaagaaggt gcggctgata aaagctatgg 1725781 tatccatgta gctcagcttg ccgaactgcc gggagatctg attgcgcgcg ctcaagatat 1725841 tttaaaagag cttgagcatt caggaaacaa accggaagtg ccggtgcaga aacctcaggt 1725901 gaaagaagag ccggcacagc tgtccttttt tgacgaagcg gaaaagccgg ctgaaacacc 1725961 aaagctttca aaaaaagaaa agcaagtgat cgatgctttc aaatcactta atatactgga 1726021 tatgacaccg cttgaagcga tgaatgaaat gtacaagctg caaaagaaat tacattaaaa 1726081 cggggtgatg aatgtggcaa aagtcatcca actgtcagat gagctttcaa ataaaatagc 1726141 ggcgggcgag gttgtggaac ggcccgcctc agtcgtcaaa gaattggtgg aaaatgcgat 1726201 cgacgctgac agcacagtca ttgaaatcga tattgaggaa gcaggccttg catccattcg 1726261 ggtcttggat aacggcgaag gaatggagaa tgaagattgc aagcgagctt tccggcgcca 1726321 cgcaacgagt aaaataaaag atgaaaatga tttattcagg gtgagaacgc tcggtttcag 1726381 gggagaagcc ctgccgagta tcgcgtcagt ctctcatctg gagattacaa caagcactgg 1726441 tgaaggagct gggacgaagc tcgtcctcca aggaggaaac atcatttccg aatcgcgttc 1726501 ctcaagcagg aagggaactg aaattgtcgt ttccaacctg ttttttaaca caccggcccg 1726561 tttgaaatat atgaaaaccg ttcatacaga gcttggaaac attacagatg tggttaaccg 1726621 tattgctctg gcgcatccag aggtatcgat ccgcctgcgc catcatggga aaaacctgct 1726681 tcaaacgaac ggaaacggag atgtgcgcca tgtactggca gcgatttacg gcacggctgt 1726741 cgccaaaaaa atgcttccgc tgcatgtgag ctccttggat tttgaagtaa agggatatat 1726801 cgccctccca gagattacac gggcgtcgag aaactatatg tcgtctgtgg tcaatggccg 1726861 ttacattaaa aatttcccgc tcgtcaaagc ggttcatgaa ggctatcata cgcttctgcc 1726921 gatcggacgc catccgatta cttttataga aattacgatg gacccgattt tagtcgatgt 1726981 caacgtgcat ccatcgaagc ttgaggtccg gctcagcaag gaaacagagc ttcatgactt 1727041 aatacgtgac ggaattaaag atgtgtttaa acagcagcag ctgattccta gtgcccaggt 1727101 cccgaaaaaa tcagcacctg ccatcaaaaa tgagcagcag tttataacct ttgatgaaaa 1727161 gcctccggaa aaaaaagttc cggaaaaatc gactgcgcca tcttattcac cgatgaagct 1727221 cagctcagtc gtaaaagagc cggttgatgc ggaggaaaaa ttgccccctc tccaatttga 1727281 tgctcctcct atcgttgatc aggaacaaac ccttgaggtg tccgatgttt cagcagaaca 1727341 gcctgaaaca tttgagcagg aatgccatga ggaacagccg cagccagcgt ctgatcgggt 1727401 tccaattatg tacccgattg gccagatgca cgggacttat atattggcac aaaacgaaaa 1727461 cggcctatat attatcgacc agcacgccgc ccaagaacgt attaaatatg agtacttccg 1727521 tgaaaaggtg ggggaggttg agcctgaggt gcaggagatg attgtaccgc tgacgttcca 1727581 ctactccaca aatgaggctt tgattattga acagcacaaa caagagctcg aaagcgtcgg 1727641 tgtcttttta gagtcattcg gctctaacag ttacatcgtc cgctgccacc cagcctggtt 1727701 tccaaaggga gaagaagcag agcttataga agaaatcatt cagcaggtgc tcgactccaa 1727761 aaatatagat attaaaaaac ttcgcgagga agcggcgatt atgatgagct gcaaaggctc 1727821 catcaaagca aatcgccacc tcagaaacga cgaaatcaaa gcgcttctgg acgacctccg 1727881 aagcacatca gacccattta catgcccgca cggccgcccg atcatcattc accactcgac 1727941 atatgagatg gaaaagatgt tcaaacgcgt gatgtagcgg gggtggtagg cattgatcca 1728001 ttctctgaat ggatcaatgc tttttttgta ctccttcgag tgtcagatta taagaaacgg 1728061 ttgtaaacgt gtgagcagtg ttaacgcatt atacttcatg gttcctccgt ataacaaaat 1728121 ttccatttac aggcaattgg gattaatgta tattttgggt gagggggtgg aaacatatgg 1728181 catgtggtcc gaagatcatt atctttttgg atgaacttga tgatccaaat gtgagaatca 1728241 ttttagaatg cagaatttaa attacaacat tgtgttttgc tccctgttcg tgtgaacagg 1728301 gagatttttt cgtttatata actggtgatg tccaaatata gggtgttatg aattttccat 1728361 atctgccatc ggctttaagc tgcttctcta ttaggctggt tatcaaaagc aagttcaatg 1728421 atagccatga aagctgatat cacaacaagc aagacatctg gaatataaat agactgcata 1728481 aagtaatctg caaaacagat cgttataaga ttgctgataa aatacagtat aaaagcaaaa 1728541 agtgcagtct ttttcaatga aagtgatttt gccaaaatga tagagataat ctttgtgagt 1728601 gggtctatga ttaaacctac agcaaagcag gctaaaataa ataaagctaa tgtttgattg 1728661 gaagcgtatg tgatgccaag tatggagaat aagcctttca tcccgaagaa aaagccgccg 1728721 aagatgactg caagcgcgat ggccgcgata aaagtaatag atacaattcc gattaatttt 1728781 gatctcaggt taaaatcttt agagtgctcg ttctgttctt tttggttcat gtatgacact 1728841 cccttcacct gcttactcat acaaacagca cccttgaatc agcccaaaat atctataagt 1728901 ctgttttctg acgaaaatag tatagcatat tttaacaaaa ccaaaaaagg ccctttccac 1728961 tggggaaggg cctttttcat catgttaact cctgagattc gccgaagctt tctctttttt 1729021 tggccaaata aaatagctgg ctgtaatgag aaagtcaatg cctataatga cagtccacag 1729081 tttaagaatg ccgctcaacg cctcggttcg ggaagagtca ttgataaaat agatcatccc 1729141 tgccaatagt cccgcaccaa ttaagtaggc cagcacatgt cttagccagc ctttcgcacc 1729201 gtgcttggca tggtccattc caaaacgttt cagcggtttt gttccttttt ttgtcacata 1729261 atattgaaac ttttcatctg cccattgaat catttgtttc ccataagcga tcgatatacc 1729321 gatgtaaaca gctgcaatcc catgggctgc ggtcgctgag gctccgcggt aaaggtccac 1729381 accagttgcc gctaacaaga tcaaatcgat aactggagtt aaggcaagga atagcagtcc 1729441 taatgtatgt cgtttgaata cgtagcgtac agcaagcccc aaaacaatga caacccaaaa 1729501 cgcaatttca cagaaaacaa tcatccatgc gataccgttc aatccattcc cctcttttca 1729561 atacagttgt attatttaaa taatatgtta ccatctttgt ttttgtaaca caactgtatt 1729621 ataaaaattg ccctctcatt tttttcttgt tacaataaag ctatgccaaa acaaattgac 1729681 catgagaaaa gaagaaaaca aattgcagaa gcaacgtggc gcgtcatttt agaacgaggg 1729741 atggagggag catcagccag aaatattgca aaggaagctg gattgtcatt agaagcttga 1729801 tcggcaatag ttacccttat tatcaagata agaaagaaaa ggatttttcg ctacgctcaa 1729861 atcctttaaa aaaacacaaa agaccacatt ttttaatgtg gtcttttatt cttcaactaa 1729921 agcacccatt agttcaacaa acgaaaattg gataaagtgg gatattttta aaatatatat 1729981 ttatgttaca gtaatattga cttttaaaaa aggattgatt ctaatgaaga aagcagacaa 1730041 gtaagcctcc taaattcact ttagataaaa atttaggagg catatcaaat gaactttaat 1730101 aaaattgatt tagacaattg gaagagaaaa gagatattta atcattattt gaaccaacaa 1730161 acgactttta gtataaccac agaaattgat attagtgttt tataccgaaa cataaaacaa 1730221 gaaggatata aattttaccc tgcatttatt ttcttagtga caagggtgat aaactcaaat 1730281 acagctttta gaactggtta caatagcgac ggagagttag gttattggga taagttagag 1730341 ccactttata caatttttga tggtgtatct aaaacattct ctggtatttg gactcctgta 1730401 aagaatgact tcaaagagtt ttatgattta tacctttctg atgtagagaa atataatggt 1730461 tcggggaaat tgtttcccaa aacacctata cctgaaaatg ctttttctct ttctattatt 1730521 ccatggactt catttactgg gtttaactta aatatcaata ataatagtaa ttaccttcta 1730581 cccattatta cagcaggaaa attcattaat aaaggtaatt caatatattt accgctatct 1730641 ttacaggtac atcattctgt ttgtgatggt tatcatgcag gattgtttat gaactctatt 1730701 caggaattgt cagataggcc taatgactgg cttttataat atgagataat gccgactgta 1730761 ctttttacag tcggttttct aatgtcacta acctgccccg ttagttgaag aaggttttta 1730821 tattacagct ccagatcatc gaattcctgt ctgagttgat tgacttggca aaagaacgag 1730881 ggctaaacaa accagataaa caaatacgtg cgcaggctca gcaaatgatg aaaacacagc 1730941 gcgcctatga tttggagtcg tacactgtta agcctctccc tgatcctgag acggtaaaat 1731001 gttattattt ccgcaacaaa agcaggtctt tctttggtga tttagacact tatttcactt 1731061 tatcaaatga aaaagaaccg tttgatcaag ctgcctattg ggaggaatgg gagcggcaaa 1731121 ttcctcattt ccacctggtg gatgtcgatt caagcaacca cttcatgata ttaaccgaac 1731181 cgaaagcgtc aacagccctg ttagaatttt gcgaaaagct ctattcaaac aggggagtag 1731241 tgaatgcgaa tttccttaag gctttccgga agaaacatga agcgagggaa gaaaaagaaa 1731301 cagatgaatt ggtgaagcgc tgagaaaaca caaacgcccc ctcttttaaa agggggcgtt 1731361 ttgaatgtta ttttgaaagt gaaacaggga gactttctaa tcctcttaaa aagacatttt 1731421 ttctccattg aatgtcatca ggtgcaaccg caagttcaat atcaggaaat ctcttcaaaa 1731481 gtgctttaaa tgcaatgtgg ccttccagcc tggcaagagg cgctcctaag cagaaatgaa 1731541 tgccaaaacc aaaagaaata tgtctattag gcgaccgatt tatatttaat atttcggggt 1731601 tctcaaaaaa attcgggtcg cgattggcag atccgatgcc tataaaaatc atgtctcctc 1731661 ttttgatcga atgcccctta tatgtaaagt cttcgatggc ccaccgattt gccatcataa 1731721 cgacaggtga ggtgtatcgc agcaattctt caaccgctgt agcgatcatt tcaggctgct 1731781 gcttgagctt ctcacattcc ttcttgtgct gcagcaatgc gagggtgcct gagccgagta 1731841 agttaacagt tgtttcaagg ccggctacaa cgagcaagaa cagcatcgaa tagagctctt 1731901 tttcgcttaa cttgctgccg ttttcctcag catgcacaag tttgctgatt aaatcgtctt 1731961 ttggctttat tcttctgtca tggatcagct tagcgatata atctttaaat tcacgaaggg 1732021 cctgatttgt cagctctcta ttaccttcag aggtatcaac catcgcattg gtccagattt 1732081 gaaactgtga ccgatcttct tttgggattc ccatcaattc agatataaca ataaaaggca 1732141 aaggggaagc gaaggatttc atgatatccg ctttattttc tttttccatt tcatctaaaa 1732201 gctgttcagc aatttgttca atgctgccgc gcagattttc aatggttcgg ggagtaaatg 1732261 cttgatgaac aagtgatctc aggcgggtat ggtcaggtgt gtcttttgcc agcatatgat 1732321 cggatacaaa atcgatatct tcactaacgt tgagcatttt gatttgttct tggttcatca 1732381 cattttttac gtctcttgta attcgattgt cttttaaaaa ggccatacaa tcatcgtatc 1732441 gggtaattaa ccaggccgga tatgtggctc cgaaccgttt taattcaaat cggtgaatgg 1732501 gctcttcctc tctaaatcgt cctaaaactg aaaaaggatt gtgatgaaac tctttaccat 1732561 gcggatgaaa catcaatttt tccatttgca ttctcctcgc ctaatagggt aaatagatga 1732621 atcaaattgc tgaattagtt tacaaaaaac agaatgattt gaaatgtaat cctgtctcta 1732681 aaactatata tctatcttag gcgtcattca atagggagaa gaacgaaaaa agtgaaaaaa 1732741 cggctcgata taaagcagcg cctttgaacg aaagctcaaa ggcgctacgc tgtattattt 1732801 tgatgaaagt ggctgtcagc tgtgctggat atcaattgta tatactgcac gatctgttac 1732861 gaccttcaat ccttcgtttt cttggtgaat atgaagctca cctaataaag gaatctcata 1732921 ggcattttgc ggaagcggta cgtttccgtc ctcagtgaat gttgttcctt cgccttctaa 1732981 aacaagctct tctttcgcaa cataatcatc aggatgattc gtactgcgta tagccacttt 1733041 ttgaaggtgg agaacaatct gatccaagtc tgatatctct tcatcatggg tcaattcacc 1733101 ttttctaata tcaagcgtct ggccgacttt tgattccagc cattgagaaa gctgtgtatt 1733161 cgtgtgtgcc atcaatattc ctccttttga tctacacgat actattccca attgctgcat 1733221 cttttacacg ggaaagagcc gccccactct ttatgtatga aacagttcgc tgttgagtgc 1733281 cttgatatag cgtacggcag aacgctggac cgattcgtcg gcattttctt tgacaacttt 1733341 agagaaagca ttgtaaagcc ggttgaattg aagcggtttt actttggctg ctatttcttc 1733401 aactttggag gcgggaaggg gaatgagatt tgggtagctg tacataaagc tgacccagtt 1733461 tcgatccgcc gcaaccgtaa tgatatctcc ggtcaataga cagcctttcc cttcattgcc 1733521 cttgctccaa tgcaaaacag caccgccttt aaaatgtccg cccagtcggt aaaggtccag 1733581 tcccggcttc atattgagcg tttcccctga ccagaagtga atgtgattgc ttggccttgt 1733641 cacccattct ttatcatcct catggatata gatcggcgcc tgaaacgctt cagcccactc 1733701 aacctgagta gagtaataat gtggatgaga caaggcgatg gcttgaatac cgcctaattc 1733761 gttgatttgg tcaattgtct tttggtcaag atatgtcatg caatcccaca gcacattgaa 1733821 gcccttatgc tgaataagat gggctgtttg tccaatcgca aactctggtt cagttttgat 1733881 gctgtaaaga tgctcttctt cctttttaag gatgttttga aggtttcctt tctcacgcat 1733941 gtcttcaagg gttgtccaag tttgtccatc gggatgaata tactgtcttt catcctcgca 1734001 aatcagacac gagttgggcg gatctacagt ctgtgcatgt tgcacaccgc atgtattgca 1734061 gatataatat ggcactttct tcacttcctt catctatttt ccattatttt accttatgat 1734121 tatgaatatt caaacgaaaa aaccggcagt tctgctgaga gagaattgcc ggcttttgat 1734181 gatgtttatt ggccgggaac ggaattttct gcgttgacag cgcccgctcc gtagatattc 1734241 ggatcttcat ctttccattt gtccgtgccg tttttcaaaa gctcttttac ttcatcaggg 1734301 gtaagatccg ggttttgctg aagaattaaa gctgcgattc ctgcgcaaat cggtgttgcc 1734361 atcgaggttc ctgacattgt aaagtactga gaccctacac ggcttgactt ttggagctta 1734421 tcaatataag aattcggaga gcgaagggaa ataatattaa cacccggcgc taaaatatcg 1734481 ggcttttctt tcccgtatac tgtcgggccg cggcttgaga aggaagcgac agtatcatca 1734541 tcgctgcttg cagtattgtt atcgtcaagc gcacctactg taatcacctt ttcgctcacg 1734601 cccgggcttg caatggtctg cgaatcaggg cctgagtttc cggcagcgac acagacgaca 1734661 atccctgcgc tccacgcttc ctcaaccgct ctgactaacg gatcttcctg ttcatgatca 1734721 tatctaaggg catcgccccc gagcgacatg ctcataatat caatcggttc atcggggttg 1734781 tcctcattgt attgaataca ccactcaaca ccctctataa tatctgctaa cgttcctgaa 1734841 ccctgcttgt ttaatacctt tacgccgatg agattggctt ccggtgcagg tccgcggtat 1734901 tgaccggaag aggatgcacc gctgcttgcg acatcacctg cacagtgtgt gccatgacca 1734961 ttatcatcgt acggctctgt tttttgattg accatgtccg cgaatccgat aattcttcct 1735021 tctagatcag gatgcgggta gattcctgta tcgacaacag cgacagtaac accttttcct 1735081 gtcagggttt gcccgtttct gacgacttcc ttcgcatggc ttgcttcggt tgccgtgtct 1735141 aaaagcgctt tgacttcgcg gtttaaatac actttacgga tattgctgca ttcagagaga 1735201 agggaatgta atgctgaagg agtaacctcg gcgctgcagc agttgatttt gttgaagcgg 1735261 ctttttagct tgctgcgttt ttctttttgc agcacctctc cagccatttg aaagccggtc 1735321 tcgtgacagc cttcctcaaa ttcgataatg actgacattt tttttctgtt ttgcaatttg 1735381 gtttcgaaaa atttatgcaa gaagcaagga gtccatttga agggcttgta aagttgcaat 1735441 acggtttccc gtaacggcca atctagcttg tgagcatttg ctctcaccat ttgtaccata 1735501 gagtacccaa acatgtattt tcctcctatt ataaggttct ctgtatactc tatgaacaga 1735561 tgataggttt ggtaagtttg tttgtcctct gtaagagaca gacaagagtt tgtttttctg 1735621 aatctttcgc attagatacg atagattcag aagctgagga aatcattggg gattgaaaaa 1735681 gaacgtttgt tcgtattata atgtgatcat atcaaactgg gaaggggaga gcaaccgtat 1735741 gaatttctac ttgcaccgat ctttggaaag ccaaatgcca atcagcatta tatatgaaga 1735801 aagacggaac gattagtaaa agaacgatta ttgtgagaca gaaaagcaaa acgaaaatca 1735861 aagcattttg tttttcgaaa caacagatca gaacattttt attggactct atcctctcct 1735921 gtgattttgt gagaacaaat aagcaaaatc tctattctgc aggccggtaa cagctgtccg 1735981 tctcagcaac cgggcagcct gttactaaaa ccctccttaa acctatatac atttatttgc 1736041 caagtgaggt tgttcctacc ttttttgtct ttcctctcaa ccttttttca ctcttatttg 1736101 aaatgaaccg ctaataaccg tgacaatcaa ttgatttttt gaaaccggga actttttcac 1736161 tgatgatatt gtgtatacaa tggtaagata aaacctattg gctaaacctc atataatgaa 1736221 ccgcgccatt cttatgaaag gagttaaaca tgagaagatt tttactaaat gtcatattag 1736281 tcttagccat tgtcttgttc ttgagatatg ttcattactc attggaacca gaaccatcaa 1736341 atcagccaga tacatattca aatttcagca gcttggcaga gaatgagagc ccagccgatt 1736401 acgatatttc atataatgag aaaaaaggaa gcaaagtctt aattatgtct ccgcatggcg 1736461 gaagaattga aggcggagta agtgagcttg tgcgttattt caataatgaa tactctacat 1736521 acctatttga agggttgaag tcccatgata accaaacact gcacattaca agcaccaact 1736581 ttgatgagcc attggcaaaa aagaaaatca aggagcatca atatgtggtg gcttttcacg 1736641 gatataaagg agagaacaag aatacccttg tagggggaac agaccgaaag cgggcgaaaa 1736701 tgattgtgag agcccttgag cggagagggt tttccgctga gttagcgtcg tctaaaagcg 1736761 gtcttgctgg attgaatgcc gaaaacatta ataaccaagg ggaaacgggg ctaagtatcc 1736821 agctggaaat cagccgtgag cagagagaag cattttttga tgatttttat tataaaaata 1736881 gaaaatacac aaagaacagt gaattttatg cttatgtcag tgcgatcaaa ggtgtcctgg 1736941 aaaaagagta ttcgtaacaa gcagatcaga agacaaaata agagaagatc agtagactga 1737001 aataggataa aaaaggaggc aaaacaatgg cagatcatca tttttattta aaagcgaact 1737061 ggccgggtaa ccgtaatgat gtcggtacga tcgaaagcgg aaacctgatc acatcgattt 1737121 ccattcctaa agaaatggat ggcccgggag aagggaccaa cccagatgaa atgcttctcg 1737181 gggcggcagc gacctgttac attattacac ttgcagcgat gatggagaga agcgggctgg 1737241 aaaaagaaga cttacagatg gagtcagaag gcattgtcaa cgttacaaaa ggagtcttta 1737301 catacaaaaa gatcattcac cgtccctctg tcgtgcttaa acatgatgct tcacaagacg 1737361 acgtcgcatt ggcgcacaaa ctttgtaaaa aagcggagtc gtcatgcatg atttcgcgtg 1737421 caattcaagg aaatgtcgag ctgcagcttg aagcctctgt gaaactgggt ggagaataaa 1737481 gaaaacagac ggtcactcac aggccgtctg ttttttatct tcagcgtggg ctttcgattg 1737541 atttagcacg accacgcctg caatgacaag cgtgagaccg aatacacctt ttaaactgat 1737601 ggtttcgcca aaaagcaaaa acccgacaat tgctgtaagc gcggtaccaa cgcccgacca 1737661 tgttgcatac gcgcttgata agtcaattgt ttttaaagaa aagcttagaa acgtaaaagc 1737721 agaaagaaat ccgactatga ctccggcaat gggccaggct tgtgtaaatc cttctgaaag 1737781 cttcaacatc gtgctcccaa acacttcaga tacaatggcg agagccaaat aaagcaatcc 1737841 tctcatcttc atcactcctt tacggccaat taagtaacac gacccctgat agtaataaaa 1737901 gaatcccgat aagccctttg gcattcagat cttccttgaa ccattttact ccgatcactg 1737961 tcgtcagcac cgtgcctgcc ccgctccaag tcgcatagga gaggctcagg ggaatatggt 1738021 ttaaagtcag ggacagcata taaaaggcga gggaatagcc aataacgacc aaagcacttg 1738081 gcttccactt tttgaagcca tcagatactt tcagcatggc tgctcctatc gattccgaac 1738141 atatggcaat cgtgaggaat atatatccta tcaacatcat gaattctcct cactatattt 1738201 ttagattaga aaaaaaactt cagctagaaa aatattagtg tatgcctatg tatgagtcaa 1738261 gagattcatt ttcacacact taaaaagacc cctttttaag gggtcttttg cgtttaataa 1738321 taaaaaggga acggggcata cggataatag gggtatccgc catacaaata aggattaaat 1738381 aaagcgcttc ctataagccc gcctgcaagg ccgccgataa acggtcctcc aaaaaatccg 1738441 aatggccggc caaacccata accaaatccg ggtcttccaa acccgtaacc gaacccgaac 1738501 ggtcttccaa acccaaatgg tctcccgaat ccgaacggcc ttccaaatat tcttgtatct 1738561 tcagggctga aatgctctaa ctcgttcatg ttttctttcc tcctgtaata aagtgtagat 1738621 gatgcagtgt attcaccctg cccggatttg attgggcgaa tcgaggaaaa ggaggatgtg 1738681 aacacattgg gcctgtatca gtctgactgg tcaaaagcac cgccccacgc acatgcttat 1738741 catgtcaaaa caacgagaga acagggccat tatcatctca tcgaagggtt tactcagccg 1738801 gcaaacggat caaataccga tcagcataca cattactata cagggatcac ttcatttgaa 1738861 aacggccatt ttcatcggta ttacggaatc tcaggaccgg cgattccctt agcagatggc 1738921 acacattatc atgaaatcga agaaacgacg tatctggcct ataacgagcc gattgagatc 1738981 cagtacggag gggttgtgta cgatcccgga gatgacagaa gaaaaacgca tcgtcatacc 1739041 ctgaaaggaa agacaaggga aattgtcggc aatgagccgc tcggctggta gaaggatgtt 1739101 taccgatgca aaaaaagggc aaaatggata ggtggttgtc catgttgaat gctataatgg 1739161 ggggagattt ataaaagaga gtgatacata ttgaataata cgaagcagcc cgttgtcatt 1739221 ttagtcggac cgacggcagt ggggaaaacc aatttaagta ttcagctagc caaatcctta 1739281 aacgcggaaa ttatcagcgg agattcgatg cagatttata aagggatgga tattggaaca 1739341 gctaaaatta ccgaacagga gatggaggga gtgccccatc atctgattga cattttagat 1739401 ccccaagact ctttctctac tgccgattat caaagcttag taagaaataa aatcagcgag 1739461 attgcaaata gaggaaagct tccgatgatt gtcggcggta cagggcttta tatacaatct 1739521 gtgctttacg attatacatt tacggaagag gcaaatgatc ccgtgtttcg agagagcatg 1739581 caaatggctg ctgagcggga aggcgctgac tttcttcatg ccaaacttgc tgcagcagat 1739641 cccgaggcag cagctgcgat tcatccgaat aatacaagaa gagtcattcg cgcactggaa 1739701 attttacata cgtccggaaa aacgatgtcc cagcatttga aggaacaaaa acgagaactt 1739761 ctgtacaatg cagtgttaat tggcctgaca atggatagag acacgcttta cgaaagaatt 1739821 aatcagcggg tcgatttgat gatgcagtca ggccttcttc cggaagtgaa acgcttatac 1739881 gacaagaacg tgagagactg tcaatcaata caggcgatag gctataaaga gctgtatgca 1739941 tattttgacg gttttgtgac actttccgat gctgtcgaac agctaaagca gaactcgagg 1740001 cggtatgcga aacgccagct gacgtggttt cgcaacaaaa tgcaggtcac atggttcgat 1740061 atgacaccgc ctgttgatat ggagctgaaa aaaaaggaaa ttttcacaca tatagcagga 1740121 aaactcgaac tttaatcgaa actgtatgat atagagaatc aaggaggacg aaacatgaaa 1740181 ccgattaata ttcaggatca gtttttgaat caaatccgga aagaaaatac gtatgtcact 1740241 gtttttttgc tgaacggctt tcagttgcgg ggccaggtga aaggctttga taactttacc 1740301 gtattgttgg aatcggaagg taagcagcag cttatatata aacatgcgat ctcaacgttt 1740361 gcgccgcaaa aaaacgtcca gcttgaactc gaatagatca aaaaatgcca tgtcaagaca 1740421 tgaggaaagg ctgtcggggg ttcccggcgg ccatttttaa catgaatcca cttttgctcc 1740481 aagctttttg tgtaagctga ccatgccaag gcacggtctt tttttatgag aacaacatac 1740541 ggaagtaaaa atggtatatt atgtataaaa tgaatttggg agtgatcgat cttgtttgaa 1740601 agtgaagcag aactgagacg aatcaggatt gcacttgtat ggatagctgt ctttttactg 1740661 ttcggggcgt gcgggaatca agataccatt attgaaacag acaacggcaa ttcagactat 1740721 gaaacgcctc agcccacctc gtttccactt gaacataacc attttggcgt tatggaggac 1740781 ggctatatca aaatttatga gtataatgag tcccgcaatg aggtaaagct gaagaaagaa 1740841 tacgcggatg atgagcttga ataaaattca caagcattcg aatttacaaa gcggatgcca 1740901 gccgctaaac taaatacaga cacagatcaa acagagggtg aaaacatgaa gcataaagtg 1740961 atcgtgaatc attgggaaga aatttgcgaa gatgattctt gctatgaata cggaacaagt 1741021 atcattgtga acggaaaaga attaatcaga gaagcgtcaa ttatcactgc tttgaaggcg 1741081 gttttagaag agatcggcgc ggatgttgaa atagaagaaa cagtagagag cgaaaaatgc 1741141 tgtgatagct taagaaaaaa aaatctagac tactaagcag ttttttttca tgttatgata 1741201 tacatcggct aaaaacgaca ccccgagtag gacgagagat gattctcgtt ctgctctctt 1741261 ttttgggccc taatgagtct gcccgtttgc ctgatttgat caaaatatga atttttcata 1741321 aaaacgaatc tatatattgt gtttttgcta gagggtagta tactatatat agtgttagtg 1741381 atgagagatt catatttttt gataggtcgt gataaaacgt ggtacaaatc atatttgatt 1741441 cgaaaacagg gaatgttcag cggtttgtga ataaaacagg ctttcagcag atacgcaagg 1741501 tggacgaaat ggaccacgtg gacactccgt ttgttttggt cacctacacg acaaacttcg 1741561 gccaggtacc ggcatcaaca caatcatttc tcgaaaaata cgcccatctc ttattgggag 1741621 tcgctgcgag cggcaacaaa gtatggggcg ataactttgc aaaaagcgcc gataccattt 1741681 caagacaata tcaggtgccg atcttgcaca aatttgaact cagcggcaca tctaaagacg 1741741 ttgaattgtt tactcaggag gtagaaagag ttgtcacaaa atcaagtgcc aaaatggatc 1741801 cagttaaata acgaaatcat gatccaaaaa gatgggaaat tccagtttga taaggataaa 1741861 gaagctgtac atagctattt tgtagattat atcaatcaaa acacagtctt ctttcacaat 1741921 ttaaaagaga agctggatta tttggttgaa aaccaatact acgaagagga attcttaagc 1741981 ctttattctt ttgaagacat taaagaagtg tttaagacag cttacgctaa gaagtttcgt 1742041 tttccttcct tcatgagtgc gtttaaattc tataatgact atgctttgaa aacgaatgac 1742101 aagaaaaaaa tcctcgagcg ttatgaggac cggatctcaa ttgttgcgct gttcttcgct 1742161 aacggcgaca ctgagaaagc aaaagaatat gtaaacctga tgatcaatca agaatatcag 1742221 ccgagcacac cgacattttt gaatgccggc agaaaacgcc gcggtgaact tgtgagctgc 1742281 ttcttgctcg aagttaatga ttctttaaat gacatttcaa gagcaatcga tatctccatg 1742341 cagctttcta agcttggtgg cggggtttct cttaacctgt ccaagcttcg cgcgaaaggt 1742401 gaagccatta aagatgttga gaatgcgaca aaaggcgttg taggcgtcat gaagcttctt 1742461 gataacgcgt tccgttacgc tgaccaaatg ggacaaagac aaggctccgg cgcggcgtat 1742521 ttaaacattt tccaccgcga tatcaatgat tttcttgata cgaaaaagat ttctgcggat 1742581 gaagatgtgc gtgtcaaaac gctttcgatc ggtgttgtca ttccggataa gttcgttgag 1742641 cttgcacgcg aggacaaagc ggcttatgta ttctacccgc acacgattta taaagagtac 1742701 ggccagcaca tggatgagat ggacatgaac gaaatgtacg acaagtttgt cgacaaccct 1742761 cgggtgaaaa aggaaaaaat caacccgcgg aaactgcttg aaaaattggc gatgcttcgt 1742821 tctgaatcag gctatccata catcatgttc caagataacg tcaataaagt gcatgcgaat 1742881 aaccatattt ccaaggtcaa attttctaac ctttgctctg aagtgctgca ggcatctcaa 1742941 gtttcttcat acacagacta tgatgaagaa gatgaaatcg gtctggatat ttcctgcaac 1743001 ctgggttcgc ttaacattct caatgtcatg gagcataaat caatcgaaaa gacagtcaag 1743061 cttgcgacag actctttaac acacgtgtct gaaacaacag acatccgtaa tgcgcctgct 1743121 gtaagacggg caaacaaagc gatgaaatca atcggcctcg gtgctatgaa ccttcacggc 1743181 taccttgcgc aaaacggcat tgcgtatgaa agtccggaag cgcgtgactt tgcaaacacg 1743241 ttctttatga tggtgaattt ctactccatc cagcgttctg cggaaatcgc aaaagagaag 1743301 ggcgaaacgt ttgatcaata tgaaggatca acctatgcga caggtgaata cttcgacaaa 1743361 tacgtttcaa ctgatttctc accgaaatac gaaaaaatcg ctaatctgtt tgaaggtatg 1743421 catatcccga cgacagagga ctggaaaaag ctaaaagcat ttgtcgctga acacggtatg 1743481 tatcacagct acagattatg cattgcgccg acaggctcta tctcatacgt tcaatcaagc 1743541 acggcgtctg ttatgccgat tatggaacgg attgaagaac gaacatacgg caactcaaaa 1743601 acgtactacc caatgcctgg gcttgcatct aataactggt tcttctataa agaagcctac 1743661 gatatggaca tgttcaaggt tgtggatatg atcgccacta tccagcagca cattgatcag 1743721 ggaatcagct ttacattgtt cttaaaagac acaatgacga cccgagattt aaaccgaatc 1743781 gatctgtatg cacatcatag aggaattaaa accatttact atgcaagaac gaaagatact 1743841 gggcaagaca gctgcctttc ttgtgttgtt tgattaaagg agagtttata gtgacaaaaa 1743901 tttatgacgc agcaaactgg tcaaagcatg aagacgattt tacccaaatg ttctataacc 1743961 aaaacgtgaa acagttctgg cttccggaag agattgcttt aaacggcgat ctcctcacat 1744021 ggaagtacct cggaaaaaat gagcaggaca cttatatgaa ggtactggcc ggacttacgc 1744081 ttcttgacac agagcagggg aatacgggga tgccgatcgt ggctgaacac gtagatggcc 1744141 accagcggaa agcggtgctg aactttatgg cgatgatgga gaacgctgtc catgcgaagt 1744201 cgtactctaa tattttcatg acccttgcac cgactgaaac gatcaatgaa gtatttgaat 1744261 gggttaaaca aaataaatat ttgcagaaaa aagcgcaaat gattgtcggg ctttacaaag 1744321 ccattcaaaa agatgatgaa atttcactgt tcaaagccat ggttgcttcc gtctatctgg 1744381 aaagcttcct tttctacagc ggtttctatt atccgttata tttctacgga caaggaaaac 1744441 tgatgcaaag cggtgagatc attaacctga tccttcgtga cgaagcgatt cacggcgtgt 1744501 atgtcggtct ccttgctcag gaaatttata ataaacagac agaagagaaa aaagcagagc 1744561 ttcgtgaatt tgcgatcgac ctcctgaatc agttatatga aaatgagctt gagtatacag 1744621 aggacttgta cgatcaagtc gggctctcac atgatgtaaa gaaattcatc cgctataatg 1744681 cgaataaagc gctgatgaac cttggatttg atccatactt cgaagaggaa gacattaatc 1744741 cgatcgtttt aaacggatta aacacaaaaa caaaatcgca tgacttcttc tctatgaagg 1744801 ggaatggcta taaaaaagcg acagttgagc cgctcaaaga tgatgacttt tattttgaag 1744861 atgaaaaaga gcagatataa tatctgctct tttcggcttg aaggttcaaa tgaggaggac 1744921 gcagtaccca tgggaaaaat ggacgaaatg attttagttg ccccgcgcga tgatgtgttt 1744981 aaaaaagaaa gcttaacctt ccagggcgtg tacagtgaag atagcagagt agcagaaatc 1745041 atggctcaga ttgaagcggc ctatcgtgaa atgagaagag gggacgcaga agaagatccg 1745101 cgtttcaagc agccgatacc ttatgtcgtc attaagcgtg aagatgaagt ttttctttac 1745161 gagcggctgg ctggcggcgg tgaatcacgt ctgcacaaca agctttctct cggttttggc 1745221 ggccatatga acgccatcga aggggcagct tcatttgctg aagtcttaaa gctgaacaca 1745281 gaccgtgagc ttgaggaaga actgcaaata aatgaagaag ataaacaggc gattgtcaca 1745341 ctgggattga tcaatgatga tgaaaacagt gttggcaaag tgcatatcgg tattctttct 1745401 gcgcttcaat taaagcctgg cgcacaagtg gaagtgaagg agaaagaaca aattgcgggt 1745461 aaatggatga aagtttctga attaaaacag gatgatatct acaaccgtct ggaaacatgg 1745521 tcacagtttg ttgttgatat tcttgaataa aaaaacccgg tttctcgcga tgaggagccg 1745581 ggttttttta tgagacgctc gtccccgtct cggctatgat tctaggatca caatagcgtc 1745641 aaagccggca tttttcgctc tggcagcgag ggtgtctgca ttgtctttgg atgaaaatgc 1745701 gccaatctgc actttgtata atccgtcctt taaaaggaca atcgagtcaa aacctttggc 1745761 ttcggcatta cttgcgagcg agtcggcatt cgctttgact ttaaatgcgc cgatttgaac 1745821 cttatataac cctgagctgg aagtcttttt aaggttaaag gcttgctcca gcccgtttgc 1745881 atgtcctctc gctaagcttt gaataaaact gctcgttttc agcttatttg catcggaaac 1745941 ggtatcaatg aagccgttct cggtcaagag ggcaggcatt gccgactccc ttaggacgtg 1746001 gaagttcgct gtttttttgc cgcgatcggc aaagtcgaca gcttgtatca cttcagagtg 1746061 aattgtcgat tgataagtcg tcgtcggggc tcctacatct ggataaatat agctttcaaa 1746121 acctgtgcct cccccggaat taacgtgaat ggacaaaaag aaatctgctc cccagttatt 1746181 tgcggcattt gtccggtcgt ttaagctgac atattggtcg cttgtccggc tcagcagcag 1746241 agaaacgcct tcatattcat tagttaatat cgtacgtaag gctaaagcga tttgcagggt 1746301 taacgttttc tcctgaaggc cattacctgt tgcgcctgga tcagacccgc catggccagg 1746361 atcaataaaa attttaacca tttttcatca cctcattaca ggatatgaaa aaacacggct 1746421 tctgcttgta cgattatcat tcaactgaaa aatgaggaaa taaccctttc acatccagaa 1746481 attatttctc gggaaagcgc acaattcaac atgaagcgac aacagatacg gtccgacatg 1746541 aaatctgtgc atacgccata tgtttgtatg tactatgggt tcggttaacc tgcactgatt 1746601 cctgctggtt ttaagctttg cgttcatatt aaatcaagca tttaaaacgt aaattgatga 1746661 ggaaagctcc tttcattaaa gacaccgctt tataaatcga aaaaaagaaa aacacttcag 1746721 gtatcttagg gcgggtaata cgtttcgtac aaaaatcagc ccgttgtatg aaaaagaaat 1746781 aatgagaaag aagctcacta taatactctg acaaaatgat taaaaacaaa atctcatggt 1746841 ttgtccaccc catgtccgtg aatacaataa gaaataaagt atttctcggg aaagcgcagg 1746901 attccttatt gttcccgaaa aaagcaattg tttcgacaca tgataggcgt ttgtcacaat 1746961 cggcatccgc ttgaatatca tatagagaga acagagaggt gaagatgttg gagcgcgctg 1747021 tgacttataa aaacaacgga cagatcaaca ttattctgaa cgggcaaaag caggtgctga 1747081 cgaatgctga ggcagaggcg gaatatcagg ctgcattgca aaaaaacgaa gcaaagcacg 1747141 gcattttgaa ggaaatcgaa aaagagatga gcgcattagt tgggatggag gaaatgaaac 1747201 gcaacatcaa ggaaatatac gcctggattt ttgtgaacca aaaacgcgcg gagcaaggct 1747261 tgaaggttgg aaagcaagcg ctgcacatga tgtttaaagg aaatccggga acgggaaaaa 1747321 cgacggttgc acggctcatc ggcaagctgt tctttgaaat gaatgtcctg tcaaaaggcc 1747381 acttaataga agcggagcgg gctgacctgg tcggggagta tatcggacac accgcccaaa 1747441 agacgagaga tttaatcaaa aagtcattag gtggcatttt gtttatagac gaagcctact 1747501 cgctggcaag aggcggcgaa aaggactttg ggaaagaagc gatcgacaca cttgtaaagc 1747561 atatggaaga caaacagcat gagtttattt tgatactcgc cggatattca cgggaaatgg 1747621 atcattttct ctcgttaaat cccggactcc aatcaagatt tcccatctcc attgattttc 1747681 cggattactc tgtgacccag ctcatggaga ttgcgaaacg aatgatcgat gaaagggaat 1747741 accagctcag tcaagaagcg gaatggaaat tgaaagatta cttaatgaca gtgaaaagca 1747801 cgacaagtcc cattaaattc agcaatggac gttttgtcag aaatgtgatc gaaaaatcga 1747861 tcagagcaca agccatgagg cttttaatgg gagaccaata cttaaaaagc gacttgatga 1747921 ccatcaaaag ccaagatctt tccattaaag aagaagcatc tggatctgca tagacctctc 1747981 agtttttgag aggtctgttt tttgctcgta tttccgcttt tcaaagcaat cgatttgtgg 1748041 tatacacatg cagggtttgg tatgataata ctactgccca atatgcaaaa gaaaggaaca 1748101 tccatttgaa cgaacaagaa acgattcagg agaaagccat tttagtcgga tgtcagctgc 1748161 cgcatatcac ggatgagcat tttgaaaatt ctatggaaga gctagcatct ctgacgaaaa 1748221 cagcagacgg aaaagtactg accagcgtca cacaaaaacg gaacagggct gacgccgcta 1748281 catatatagg aaaagggaag gtagaagagc tgaaggcact cgtggaagag cttgaagctg 1748341 atctcctcat ctttaatgat gaactgtcgc caagtcagct gaagtcattg gcaacagcaa 1748401 ttgaagtgaa gatgattgac cgcacgcaat tgatattaga tatttttgca aagcgggcga 1748461 gaacgagaga aggcaaactt caaattgagc tggctcagct gcaatatgca ctgccgcgtc 1748521 tgacgggaca agggatcaac ctttcccggc aaggcggagg aattggggca agaggtcccg 1748581 gggaaacgaa actggaaacc gaccgccgcc atatcagaaa tcgcattcat gaaatcaaca 1748641 cacagctttc cactgtcatt cgccatagaa gccgataccg tgaaagaaga aagaaaaacg 1748701 gtgtgcttca aattgcgctt gtcggctata caaacgcagg gaaatcaaca tggttcaacc 1748761 gcctgacgag tgctgacagc tatgaagaag acctcctgtt tgccacgctg gacccgatga 1748821 ccagaaaaat ggtcctgcca agcggctaca gtgttcttct ttcagataca gtaggattta 1748881 ttcaggatct tccgacgaca ttgattgctg cattccgctc aacgcttgag gaagtaaaag 1748941 aagcggattt aattctgcat ttaattgatt cttcaaatga ggattatgcg ggacatgaaa 1749001 aaacagtgct tcggctgctt gaggagcttg aagcagatga tatcccgatg ctgacggctt 1749061 acaataaacg tgatcaaaaa ctgcctgatt ttataccgac cgccggaagg gatcacatta 1749121 tggtcagtgc gaaatttgag gacgacgctg cagcctttaa agaagcgatt cagcgctatt 1749181 tgcgccaaga actgttaacg tcttttgaag cacatgtgcc ggcaagtgaa gggaagctcc 1749241 tttccagaat caaatcggaa acgatggtag accgcttcta ttttaatgaa gaaaatgaac 1749301 agtatgacat atccggctat gtccaagaag agcaaagtat catcggtgaa ttaaagaagt 1749361 atatgtagga aggaaatata aagacatgtt tgacacatta acacacggag aattattgaa 1749421 gaaaacggca atggaagtgg aagcggacat tgccggcatt cataaacaaa tagaagaaat 1749481 cagcgagcga aatgagtgga gagtgcttca aagctataga aaacacaaag taagcgacac 1749541 tcatttcacg ccgtctactg gatacggcta tgatgatatc ggaagagaca cgcttgaaag 1749601 catatatgcg gatgtgtttg gcggagaagc ggggcttgta aggccgcaaa tcatttcagg 1749661 cacacatgcc atctcaattg ctttgttcgg tgtcctcaga ccgggggacg agctccttta 1749721 tatcacgggc aagccgtatg atacgctaga ggaaattgtg ggcgtcaggg gtggagaaaa 1749781 cgctggttcg ttaaaggatt ttcaaatcgg ctataatgcg gttgatctga cgaaagacgg 1749841 aaagatagac tatgatgcag tcgccgctgc gatcaatccg aagacaaaag taatcggcat 1749901 tcagcgctca aaaggatatg cgaatcgccc ttctttctta attagtgaaa taaaagaaat 1749961 gatccgtttt gtaaaagaaa tcaatgaaaa tctgatcgtc tttgtggaca actgttacgg 1750021 agaatttgtg gaagagcttg agccttgcca tgtcggagcc gacctgatgg cgggatctct 1750081 cattaaaaat cccggcggcg gccttgcgaa aacaggcggc tacctcgtcg gaaaagcgaa 1750141 atggattgaa gcttgctcat accgtatgac gtcacccggc atcggcagag aagcgggggc 1750201 atctctttac tcgctccaag aaatgtacca aggcttcttt ttggcgcctc acgttgtgtc 1750261 tcaaagttta aagggagcgg tgtttacagc gagattcctt gaaaaactcg gcttcacttc 1750321 aaacccgaaa tgggatgcga aaagaacgga tttaatacaa tccgttgagt tttctgacag 1750381 agaaaagatg attgcttttt gccaggctat tcaatttgca tcgccaatca atgctcatgt 1750441 gacgccttat ccagcctaca tgcctggata cgaggatgat gtcattatgg cagcagggac 1750501 gtttattcaa ggagcaagca tcgaattatc agctgatggc cctatccgcc cgccgtatgt 1750561 agcgtatgtt cagggaggat taacctattc gcatgtgaag aatgccatat gcagtgcagt 1750621 ggattcattg atgcaaaagc aattaattta aattttttaa aaatttctct ggatttgatg 1750681 ttaagaatcc ttacatcgta ttgacacata atataacatc acctataatg aaactaagtt 1750741 aagaaaagga ggaaattgag atgagtgata atattcgccg ctcaatgcct ttatttccaa 1750801 taggaattgt catgcagtta actgagttat cagcaagaca aattcgatat tatgaggaaa 1750861 atggactgat atttccagcc agaagtgaag gaaatagacg attattttca tttcatgatg 1750921 tagataaact gttagaaatc aagcacctga tagaacaagg tgtaaacatg gcaggaatta 1750981 aacagattct ggcgaaagcc gaagccgagc cagaacaaaa acaaaacgag aagacgaaaa 1751041 aaccaatgaa acatgatctg tccgatgacg aactgagaca gctcctgaaa aacgagctca 1751101 tgcaagccgg ccgttttcaa agagggaata cattccgtca aggcgacatg tcccgcttct 1751161 ttcattaatc cgttagcaac tgttttgcta tatacattta ccttttaaga ggaggaattt 1751221 taccaaatgg caaagtacac tagagaagat atcgaaaaat tagtaaaaga agaaaacgtg 1751281 aagtatatcc gccttcaatt tactgacatt cttggaacaa tcaagaatgt tgagattcct 1751341 gtaagccagc ttggaaaagc gcttgataat aaagtcatgt ttgacggttc ttctattgag 1751401 ggattcgttc gtatcgaaga gtcagacatg tacctgtatc cagatctaaa tacatttgtt 1751461 atcttcccat ggacagctga aaaaggtaaa gtagcacgtt tcatctgtga tatttacaat 1751521 ccggatggca caccttttga aggtgacccg cgaaacaact taaaacggat tctgaaagaa 1751581 atggaagacc tcggcttcag tgattttaac cttgggcctg agcctgaatt cttcttattc 1751641 aaattggacg aaaaaggcga gccgacgctt gaactaaacg acaaaggcgg atatttcgac 1751701 ttagctccaa ctgatttagg agaaaactgc cgccgcgata tcgtacttga gcttgaagag 1751761 atgggctttg aaatcgaagc gtctcaccac gaagtagcac ctggtcagca cgaaatcgac 1751821 tttaaatatg ctggagcagt ccgctcttgt gatgacatcc aaacatttaa actagttgtc 1751881 aaaacaattg cccgtaaaca cggcctgcat gcgacattta tgccaaaacc attgttcggt 1751941 gtaaacggtt caggtatgca ctgcaatcta tcactcttca aaaatggtgt taacgcattc 1752001 tttgacgaaa acgcagatct tcagttaagt gaaacagcga agcacttcat tgcaggtatc 1752061 gtgaagcacg caacaagctt tacagcagta acaaacccga cagtaaactc ttacaaacgt 1752121 cttgttcctg gctatgaagc accttgttat gtagcatgga gcgcgcaaaa cagaagcccg 1752181 cttatccgta tcccggcttc tcgcggcatc agcacacgtg ttgaagtacg cagtgtagac 1752241 ccagctgcaa acccatacct tgcacttagc gtattgcttg ctgcaggatt agacggaatc 1752301 aaaaacaaac tggaagcgcc ggctccaatc gaccgcaaca tctatgtgat gagcaaagaa 1752361 gagcgcatgg aaaacggaat cgttgacctt ccagcaacac ttgcggaagc actagaagaa 1752421 ttcaaatcaa acgaagtcat ggtcaaagcg ctgggcgagc acctattcga acacttcatc 1752481 gaagcaaaag aaatcgaatg ggatatgttc cgcacgcaag tacatccttg ggaacgcgaa 1752541 cagtatatgt ctcagtatta atatctcaat cccttggcac taaaagtgtc aggggatttt 1752601 ttatgttaat aggtaataaa ttatggagcg gcactgctaa aaagcagggt cacttttagt 1752661 ctatgtcact aataattcta tgtactaaat ttttaattag ggaaataatt ccacgcttaa 1752721 ggaagcaata cgcataaata attcgacaaa ttctgtgata attccattgt tcaatacttc 1752781 taccagcaat aataagatga gtaaggtaga tgtttatcat tgacatcata accaaatgaa 1752841 tccataatta cgttgaaatc taaatcaatt ttcaaaaagg agatttctat gaaaaaattg 1752901 actatcttct ccgggggatt aggagcggtt ttttctgtac tggctcaact gtttgcggtt 1752961 atagatgact cttacacttt ggggaattta tggtttttag gtgctttggc gggaattata 1753021 accatgcttg cttcaatcca gacaaataat aaaccagtct tcagcatatt attaattgct 1753081 agttcagtaa taggtctact tggaactggt cttgtataca tcataccaac actgttcaat 1753141 ataataataa tttataaatt ttcaaaagta agccaataag ccaatgggaa aattaaggtt 1753201 ctttttttat ttaacatccc tttgacaagg tcggtgataa atcgcagaat gtttatgctt 1753261 gcaactaatc caccagcggg ggcatcggtg ggcatgatta tctaacgcca tgtttctagg 1753321 ataccggaat tgaaacattt gctgaggcat ttcgtgaagc tgatcaccaa atgaccattt 1753381 ccatagaggc acgtctaaag aagctatcat aggaggacaa tactgtgtgg aaagctttaa 1753441 gtcaattact caagaaacag aaaaatcaaa gtccaagcga tgaagattat atacagattc 1753501 cagaattaga agtaaaagtt ttggggatgc ttcacagtat caatatagac ctggttaatg 1753561 taatagccca agcagaaaag tctaaggagt ttataggaca aatcgaaggc atctggcatt 1753621 ctatagcaaa tcaattttat tcactcgccc aagggtttga gaatgaggat atcaataagc 1753681 tttctgcgga tcttgatcat gctgccgcca cttgggaagc tgttgctaat aaagcaaaag 1753741 agtttgtaac aaattcatac caagggtaaa agaaaaataa gggcctgaaa gggctctttt 1753801 gcttatagtc atatttcccg taagtattac tttttggatt taataaattt taaagcgtgt 1753861 ttgtttcact gaattcatag tcaaaagggg aatgttttta tgcttggaat caacgttgaa 1753921 aaatcaaatg aaaacttaat tatcaattgg cagctatcca aaattgaaat tccaatcaaa 1753981 gaaatcaatg atgtatttct tgatccaaac tatgggggag aggagaaaag cgcagtaagg 1754041 attgggtttc cttatggctc aacagatagg gtagtaatta aaacagcacg taacacttac 1754101 attttgttca ccactaatcc tgctttaatt atgagtaaaa ttgtttctta ataaacagtt 1754161 tatgtccctt ttaaatttat ctattaatgt tctgtgtggt aaaatttagt gagatgattt 1754221 aaggaggagg agcatttatg gaagaaataa aagttagttc acatgacact agatggtatt 1754281 aagaaagcag tttctaaata tggtacattc cctatgtttc atcatggagg atatgtcatg 1754341 gaagatgcta cttttcattt caaagatcct gctagtcctc aagaaattag cgatatagaa 1754401 cagaagctag gtgttacttt ccctaatgac tataaagagt ttttgttaca gcacaatggg 1754461 atggaaatgt ttgatgggat tgaaatactt agcttagagg gaatcattga atataatgag 1754521 gttcaagatt tcccagaggg atacgtttta attggatatc attttgatgg aagatatgtc 1754581 atagacacaa acaaatcaaa aaatggatta ggctatatgc tatatctaga ctcaattgat 1754641 gatattgaag atgcgattaa cttagattct aatttcgaga tatggtttga tatgctagtg 1754701 tctttaaatg gaacgaaata ttgggaagta aatccgaatc tccaagagta ttataaactg 1754761 gtttcagaat aacacttcgg caaaagaaaa aattatgact aatttcaaca accaaagaaa 1754821 ctgcaatttg agggaagtat aatgacaatt tacgagcaaa ttaaggatgc tttgaaaaat 1754881 aagatcaatg agttggtttc acctcaagaa gtaaagaaaa cccttcaaga aaaatacgga 1754941 actaatccgg atagcattat tttatcagat tattgttata accggtataa taaggggatt 1755001 tcttttaata agcacctctt tgaatatatg aatagaagtt cttacaaata cttaggtgaa 1755061 aactctcttt atacaggact tattttcaga aaatcaaaag gggaagataa ggaagttatc 1755121 gtaggcgaat gggtaaacgg tgttaaatca ctccgagaag cttctgttac taataaccaa 1755181 ataaatgatc aagccgaaat cattagtaaa gaacaacttg taaaccttta taatgaatat 1755241 aaccaaatcc tgagatatga aatgaatgta ttgaactgta agcctacaga attgaggcat 1755301 ttaattggca gaatcggtga attcatttgt gcaatccaaa ccaacggcac tctggcacgt 1755361 caaactaatc agcatggatt tgatgttgtg agtgatggca gacggattag tgtaaaaaca 1755421 acagctcaat caagtggttt tatttcgata aataaaaata cattttatga ttttgatgat 1755481 ttttttgtag ttcaatacgt aaatgatgat tttaaagtta ttttcttcgg ctcaaaggaa 1755541 gaagtgcaaa aaataagcag aatttatgga agccaatacg aagttgaaat ttcacttctt 1755601 aaaaagctta ataaggaata ccaattaaat taaacaatct tgttggtaac aaacatcctc 1755661 ttacttattg taagaggatg tttgtttaat tcttacatat tttatctttg caatctggct 1755721 tacgagttgc atccacagta aatgatctta cttcgtcttt agttttgtca taaattcccc 1755781 atattacccc tcagagaagg atagggggat tattttggag aatcatattc cattgcttgt 1755841 tcacagtcag taatccttga gttgttctag caagaggcaa tattgttgaa taagaatagt 1755901 tttaaagagg ttattgttgt cttcatattg aaataaagat taagtatatt agaggggagt 1755961 tgctttaatg cacataacaa caaaaaggtt attgatacgt gaatttgaat tcaaagattg 1756021 gcaagcagta tatgagtata catctgatag taatgtaatg aagtatatac ctgaaggggt 1756081 ttttactgaa gaagatgcaa aggcatttgt aaataaaaac aaaggtgata acgctgaaaa 1756141 attccctgtc atactaagag atgaagactg tcttataggc catattgttt tttataagta 1756201 ttttggtgaa catacatatg aaattgggtg ggtgtttaat cccaattatc aaaataaagg 1756261 gtatgcttct gaggcagccc aagctatctt ggaatatgga tttaaagaaa tgaacttaca 1756321 taggattata gctacgtgtc aacctgagaa tattccctca taccgagtta tgaagaagat 1756381 tggaatgaga agagaaggct tttttaaaaa atgtattcca aaaggcaatg aatggtggga 1756441 tgaatattat tacgctattt tagaggaaga gtggaattga actttattga gtgcggcaat 1756501 acaaacaaat tatcaccctc tacttagaac atattagtta aatgaaggtg atatataaag 1756561 tgatatgaca gtgattaaat gggattcaat gagctccggt gaattgtttt taggtgagtt 1756621 cactaaggat gatacctgat acgcagccat accattcgag cgttaatcat tttataactg 1756681 atcttttcac ttttgcccac gggggaataa gaccctattt aagtttgcca gacgattgtt 1756741 tgatccgttg ttgatgattg tcaggatttt ttgtgaagga atatctttat atagtggttg 1756801 attattccct tctggtaaaa attgatctat gttgaattgc ttaacatgtc attgaactca 1756861 gagaataaag tgaacctgcc acagatgttc attatctttt agggggttcc aaaaagaccg 1756921 tattcctatc gatcgctcag agtgaaaatg gtatactaaa gttacaatca caggaaggaa 1756981 ttacaatttt tttagatcta cataaaatca tctgattaac cgaaagtgag aatgtgtgaa 1757041 tgaatttaat agggtatatt gaggaaaggt ttcaaaacct cgaattaatt cctagcatct 1757101 ataatcaatg gggcacagga atccattttt gtcttgggga aaatatctat caactcaaag 1757161 caaatgaaga attgaattta aagatgtttc ggattgtata tgaacaaacc tcaatcattt 1757221 ttaatgaatt atttgaacaa aatgatgaca tattccttgt gacgaatatg tataagcaca 1757281 aaaagaaaga gaaatgtata agaaaattaa aggtgtatca accgtttcta aaatgtaaaa 1757341 atcatttgaa tcaaattatg gtgaagacat atccctatcc tttcgaaatc aataaagctg 1757401 aagaatacga gatgcaacaa ttttccctgt tatgcaaacc tcgagactta cgtgtaactg 1757461 aattacttaa agcagccagt aatgaggatt ttccacaaaa accgaaattc ggaggttact 1757521 ctattgatta ccctgatgtt ttctttgtga acattacaaa agacattatt ttctttatct 1757581 atgatgaccg cggatgcgaa gtcatagctc atgatttcaa acgaatacgt ccactttatg 1757641 aaaaatatca cgactgggta gaagagtata agtgcatgta atactttttt taaaaacgat 1757701 ttatcaggaa aggcagaatt agattatgag ggccttacat acaagatgta aacggttatt 1757761 gaaactaaga tggtattatg tgatgatgag agatctgcat ttttattagt acttgatgaa 1757821 agattagtgg attttgattc tcaaggtgga aaccatatta gtgtttattt agttactcac 1757881 tttgagttat ctgatcaatc gtataaagat gtattaagct ttaatgatga tcttttgggt 1757941 atggagcata actgttcgta tgcaatggat attctaagcg ttaaagagga acttgatttc 1758001 gatttcccat ttaatatgct tgcaataaaa agctatgtac aagaattaat aaaaatgtta 1758061 gggattgata tcactctgcc tgaaatgaaa gaaagagatt ttgacaaact ttctcaaaac 1758121 taaataaaac tactattttt aaagagaacg gagacttgct ttcaatatga atgttaaaaa 1758181 agctgcagct gttttttcaa tcactattcc aattatctca gccatcttaa ttattaattt 1758241 ttttacagga tttatgtcaa ttccatggca aggaatgccg gtgttttttc cattattact 1758301 ttctcctata ggaatcattt tagcgttcgt ttcaataaag acaaataaac ggtgtgctgt 1758361 atatgggatt gtcttaaatg caattatgtt tccatttcct tttttctggt ttatcggagg 1758421 ggctttgtta tttggagttt aaaatccatt aggcattacg cttatacatt ggtattttcg 1758481 agcttgtcaa aagaaggaat aaaaaaactt cagaattgct tggctttact ttatgttgaa 1758541 aggggtcgag taaggtggat aggaaaaagg atgaaataca aagaaaatat agggaacaaa 1758601 tgagggagaa gaaagaacga gaaaaagaag atggcagttc acatactttt gaaattgttg 1758661 ttgtgctagc cattatcatt ttgatgtttt tctttaattc agttttcaag gctttttaga 1758721 tattgtacag atgactttca ggatgtttga aaaaataacc ctttgagata tataccgcat 1758781 gaaagtattg aaggacttat gaaaattcaa gagccagttg aatcttaata attaatcacc 1758841 aaataatggg gatgtaaaat gaagttgtat aatgaattta tcaatatagc taaaacgttt 1758901 aataaagagt tagacataat tccattatta tatggatctt taggtcttga aaaggtaact 1758961 gggttagact tttccccaga agatattgat ctccttattc ctttaatttt tttagaggaa 1759021 aagtgggaaa aactaaaaaa agtgatggaa ctgcatggat acaaaatggt tgatttacat 1759081 gagcatgaat ttaagaaaac taatacaaaa ataggcattt cttacattga ggatttaaaa 1759141 ccatttgcag atgtagacta taataaccta gagatttttg aagatggcgg agcgaaatat 1759201 catttgctaa cgattgatga ttacctcaag atttataaaa agtctttatt agatggttat 1759261 agaagaagga agaagaatca taaagaccaa agtaaaatta acatattgaa taaattaata 1759321 cggaattaat ttctgtattc ccttttgttt ccagtctcaa ttaaaatttt taagattaaa 1759381 ataagtttga aggaaaaatc atagtgttta acacagccat taatcctcag acagtcaaat 1759441 agccatttct actccggttg aaagcttctc tatttttgct tcttatttat ctttcctgta 1759501 ttgatatatg tatgtagggt tggacttata acataaacta ttctggccat tccgttcttt 1759561 caattcatga ccgggcttgc catcagcata aatctaggct aacagtctcc atacatcctg 1759621 tgatcacctt tatcaaactc ttaaatgcaa cttaccacta accaattctt tatttcgcat 1759681 agatcatctt tgtcatgtgt ttacacaaga atctgttttg gactgagaca ctgaatataa 1759741 caaaacagtc aaaaatcaat atttaattca ttctgtttaa actttctgaa aaagatgttg 1759801 aaaaagtcga aaggatttta taatattaag tcaagttagt ttgtttgatc aacaaactaa 1759861 tgaaatgaac tttcattatc cacaagataa gatcttacta atatggatgg aagggggata 1759921 agagggtcga tttaatggag ctaaacaata taagaaacga aagaatgagg cttttatcct 1759981 tttccaggta tataaggtat gacgaaaaaa gatgaatttt ttgcttgctg atcaccatat 1760041 ttttttgcac tgttttgaaa gcgcttttat aaaagtttac tgaccgtaaa ttcgagaaat 1760101 tgttataccg tttcacactg ttccatatta aaggatcgaa aaggggagaa atcatgctca 1760161 gtgaaaatgt aaagaagatt agcatggttg aaaaagttgg atatgcgtct ggagattttg 1760221 cttgtaattt aatttatgca acagtgtcta cgtatctttt gttcttctat acagatgttt 1760281 ttggtttatc ggcagcagca gccggtacta tgtttttagt ggttagaata atcgacgctc 1760341 tcgctgatcc ttttatcgga acaatagttg acagaacgaa cagcagattt ggacgcttta 1760401 gaccgtatct tttattcgga gcttttccat ttgtcatact ggcaatactc tgttttacaa 1760461 caccagactt ttcggatatg gggaaattaa tatatgccta tataacctat gttggcttgt 1760521 cgcttacata cacaacgata aacgttccat atggcgcgtt aacttctgca atgactagaa 1760581 ataatcaaga agttgttagt ataacttctg ttcgcatgtt atttgcgaat cttgggggac 1760641 ttgtcgttgc attttttgtt cccttactgg ctgcttattt aagcgatact tccggcaacg 1760701 agtctcttgg ctggcaacta accatgggta ttttgggaat gataggcggg tgccttttaa 1760761 tcttttgttt taaaagcaca aaagagcggg tcactcttca aaaatccgaa gagaaaatta 1760821 aatttacgga tatatttgag cagtttcgtg ttaatcgtcc acttgttgta ttaagtattt 1760881 tctttattat tatttttgga gtgaattcca tcagtaattc ggttggcatt tactacgtaa 1760941 cgtataactt agaaagagag gatttggtga agtggtacgg tttgatagga agtttacccg 1761001 ctttggtcat tttaccgttt attccaaggc ttcatcaatt tttggggaaa aagaaattac 1761061 taaactatgc attattactg aatattatag gcctcttagc tttactgttt gttccgccaa 1761121 gtaatgttta cctcatactt gtctgtcgat taatcgctgc tgctggaagt ctcactgccg 1761181 ggggatatat gtgggcgctt attcctgaaa caattgaata tggagagtac aggactggga 1761241 aaagaatggg tgggctcatt tacgctataa tcggattttt ctttaagttt ggtatggcct 1761301 taggaggagt tgttccgggt ctggttcttg ataagtttgg atatgtagca aatcaggcac 1761361 aaaccccggc ggccttaatg gggattttaa ttacaacaac cattattccc gtgttcttgc 1761421 ttgttctagc tttaattgat attaatttct ataacttaga tgagaaaaaa tataaaaaca 1761481 tggttcgaga attagagaat agagacaaag tttatttgga tcatattgat gatttcaagg 1761541 cttaaaaaag aaaataaact gaggaggagt cccaaatgaa gattaccaat cccgtactta 1761601 aaggattcaa tcccgatcca agtatttgta gagcaggaga ggattattat atcgctgtat 1761661 ctacatttga gtggtttccg ggagtccaga tacaccactc aaaagattta gtaaattggc 1761721 acttagttgc acatccatta cagagagttt cacaattaga catgaaagga aacccaaatt 1761781 caggtggagt ttgggcacca tgtttaagct atagtgatgg gaagttttgg ctgatctata 1761841 cggatgttaa ggtagtagat ggcgcatgga aagattgtca caattattta gttacttgtg 1761901 aaacgattaa tggtgattgg agtgagccga ttaaattaaa tagctcgggg tttgatgctt 1761961 ctttgttcca tgatacggat ggaaaaaagt atttattaaa tatgttatgg gatcaccgta 1762021 ttgatcggca ctcatttgga ggaattgtta tacaggaata ttctgataaa gagcaaaaat 1762081 taatcggtaa accaaaagtt atatttgaag gaactgatag aaaactgaca gaagctccgc 1762141 atctttatca tatcgggaac tattattatt tattaactgc agaaggagga acacggtacg 1762201 aacatgctgc tacaattgct cgttctgcaa atattgaggg gccatatgaa gttcatcccg 1762261 ataatccaat tttaacgtca tggcatgacc caggaaatcc attgcaaaaa tgtggtcatg 1762321 catccattgt tcaaacacat acagatgagt ggtatttagc tcatttaacg ggacgtccta 1762381 ttcatcctga cgatgattca atttttcagc agagaggata ctgtcctttg ggcagagaaa 1762441 cagctattca aaaactttac tggaaagatg aatggcccta tgtagtaggt ggaaaagaag 1762501 gaagcttgga ggtagatgca ccttctatac ccgaaacaat atttgaagca acgtacccgg 1762561 aagttgatga atttgaggat tcaacattaa atataaattt tcaaacttta aggattccat 1762621 tcacgaatga attaggttca ttgactcaag cgccaaatca tttacgatta ttcggtcatg 1762681 aatcattgac ctcgacattt actcaggcat ttgtagccag acgctggcaa agtctccatt 1762741 ttgaagccga aactgctgtt gagttttatc cggaaaattt tcaacaagcc gctgggttgg 1762801 tgaattacta caatacagag aactggacgg ctcttcaagt cacgcatgat gaagaacttg 1762861 ggcgcattct tgaattaaca atatgtgaca acttttcttt ttcacagcca ttaaataata 1762921 aaattgttat tcctcgtgaa gtaaagtatg tatatttaag agtaaatatt gaaaaggaca 1762981 aatattatta tttctattct tttaacaaag aagattggca caaaattgac attgcactgg 1763041 aatcgaaaaa attatcagat gattatatcc gtgggggagg attcttcaca ggggcctttg 1763101 tagggatgca atgccaagat accagtggta atcatattcc ggccgacttt agatattttc 1763161 gttataaaga aaaataattt gcacatgaaa aaggagattt ctattttaga actccttttt 1763221 catatgagaa ggtgccatgt cactattgct tcagaaatac tcctagaata aaaaaactca 1763281 tctttaaaga tgagctgtcc attccataaa aaattacatt gtaatcatgt ccagaaaatg 1763341 atcaatcaca atggaggaca ttcctaatgc cggtgcattc tgtcctaagg aagatggcaa 1763401 taattcatag ctattgccta attgggaata aacccttgat gatacttcac ttctcattga 1763461 atttaaaacc ataggatgcg attcaattat gctatttctt aaaattacgg cttgtgggtt 1763521 gaaagtattt agaatattgg taaggcctat tcctaaatag aatccaaaat tttgtaatgc 1763581 atttaaggtt ccgatatcat tcagatgggc gaggtttatg atatcttgat aggacagttt 1763641 tttctctttg gtctgaagag attttaataa agccttctct gaagcataca attcccagca 1763701 tcctcggttt ccgcaactgc atttaggacc attaaagtct attgtcatat gtcccatttc 1763761 tccagagaag ccgcttactc ctctatataa atgattgttg ataataacac cgatccctat 1763821 tcctgtgctg atacttacgt aaataatgtt atcgtgattt tttgcagctc caaatacttt 1763881 ttctccatat gcgccagcat ttgcctcatt ttcaataaaa acaggcacat tgtacttctc 1763941 ttgtatcgaa gattttaagt caatatctct ccagttggag ttcggagtga aaacaatttt 1764001 ttgatcttta tcaatgagtc caggcacgca aatacctata ccaataagcc cgtacggaga 1764061 ttggggcatt tgcgtaataa agtgatgaat catatcaatc aaaatgtctt tcgttatttc 1764121 tggagaattg gattccaaat ggcggtattg atcaagaacg attgttcctt caaggtctgt 1764181 taaaatgcca ttaatataat ccacaccaac atctattcca acggagtatc ctgccttttt 1764241 attaaaaaca agcatgacag gtcttcttcc gccacttgat tgtccttgac ctatttcaaa 1764301 taccatactt tctttcatta acgtgtttac ctgtgatgag acagttgatt tatttaatcc 1764361 agtcatttca gataattttg ctcttgaaat aggtgaattt ttaaggattt cttttaataa 1764421 taacttttga tttacttttt tgacaaaggt ttgatcagcg atatccactt catccactcc 1764481 atttgtttaa tctttaaatt aagtatcaac atagtacata gcgaatcttc cctttattat 1764541 atctaatgtg ttcataaaaa actaaaaaaa atattgaaaa tactgacgag gttatataag 1764601 atgaaaataa gttagtttgt ttaaacaaca aactaatagg tgatgtactt actatatgaa 1764661 ataaaatgca tctgtatttg aatgaattta tttttaaggg ggaaatcaca tggctcaatc 1764721 tcattccagt tcaatcaact attttggaag cgcaaacaaa gtggtttacg aagggaaaga 1764781 ttcgactaat cctttagcat ttaaatatta taatcctcaa gaagtaatcg gcggaaaaac 1764841 gctgaaagag catttgcgat tttctattgc ctattggcat acatttactg ctgatggtac 1764901 agacgttttt ggagcagcta cgatgcaaag accatgggat cactataaag gcatggatct 1764961 agcgaagatg agagtagaag cagcatttga gatgtttgaa aaactagatg caccattctt 1765021 tgcttttcat gaccgggata ttgcaccaga aggcagtacg ctaaaagaga caaaccaaaa 1765081 tttagatatg atcatgggca tgattaaaga ttacatgaga aatagcggcg ttaagctatt 1765141 atggaataca gcaaacatgt ttacgaatcc ccgtttcgtc catggtgccg cgacttcttg 1765201 caatgcagat gtgtttgcgt atgctgcagc acaagtgaaa aaagggttag aaacagcaaa 1765261 agagcttggc gctgagaact atgtattttg gggcggccgt gaaggatatg aaacattgtt 1765321 aaataccgat ttaaaatttg agcttgataa tttggctaga tttatgcata tggcagtgga 1765381 ttatgcgaag gaaatcgggt acacagggca gtttttgatt gagccaaaac caaaagagcc 1765441 gaccacccat caatacgata cagatgcagc aacaaccatt gcctttttga agcaatatgg 1765501 cttagacaat cattttaaat taaatcttga agccaatcat gccacattag ccgggcatac 1765561 attcgaacat gaattacgca tggcaagagt acatggtctg cttggctctg ttgacgcaaa 1765621 ccagggtcat cctcttttag gctgggacac ggatgaattt ccgacggatt tatattctac 1765681 gacattagca atgtacgaaa tcctgcaaaa tggcggcctt ggaagcggcg gattaaactt 1765741 tgacgcgaag gtcagaagat cttctttcga gcctgatgat ctaatatatg cccatattgc 1765801 agggatggat gcatttgcaa gaggattgaa agttgcccac aaattaatcg aagatcgtgt 1765861 gtttgaagat gtgattcaac atcgttaccg cagctttact gaagggattg gtcttgaaat 1765921 tatagaagga agagctaatt tccacacact tgagcaatat gcgctaaatc ataaatcaat 1765981 taaaaacgaa tctggaagac aggagaaatt aaaagcgata ttgaaccaat acattttaga 1766041 agtataacag gataagctcc agatcctgct atcaatacca agtcactgaa ttacccgtca 1766101 tgattccttt cctattgctt gttgttatga cgggtaactt ctataattag gatttattta 1766161 gagtgaatgg ttttttaaaa gggcaaggag tgaaaaaatg aagtatgtca ttggaataga 1766221 tcttggaacg agtgctgtta aaaccatttt agttaaccaa aacggcaagg tttgtgcaga 1766281 aacgtccaaa aggtatccgc tcatccaaga gaaggcggga tatagtgagc aaaatcctga 1766341 agactgggtt cagcaaacaa ttgaagcatt ggctgaattg gtttctatat ccaatgttca 1766401 agccaaggat attgacggga taagctattc gggacaaatg catggattag tactgcttga 1766461 ccaagatcgt caggtgttac gtaatgcaat tctttggaat gataccagaa caacgcctca 1766521 atgtataagg atgaccgaga aatttggcga tcatcttctt gacatcacaa aaaaccgtgt 1766581 tttagaaggg tttacattac ctaaaatgtt atgggtaaag gaacatgaac ctgaactttt 1766641 taaaaaaact gctgtgtttt tgcttccgaa agactacgtg cgattccgta tgaccggtgt 1766701 cattcacacc gaatactccg atgcagcagg aactttactt ttacatatta ctcgcaagga 1766761 gtggagcaat gatatttgca atcaaattgg tatttctgca gatatttgtc ctccgcttgt 1766821 tgaatctcat gattgtgtag gatcgctgct tccgcacgtt gccgcgaaga ccgggctatt 1766881 agaaaaaaca aaagtgtacg ctgggggagc agataatgct tgcggcgcta ttggagcagg 1766941 tatcctttct tccggaaaaa cattatgcag tattgggacg tcaggggtca tactttccta 1767001 cgaagaagaa aaagaaagag actttaaagg gaaagtccac ttttttaatc atggaaaaaa 1767061 ggattctttt tatacgatgg gcgtcacgct cgctgcagga tacagcttgg actggtttaa 1767121 aagaacgttt gcaccaaacg aatcgtttga gcaattattg cagggggtgg aagctattcc 1767181 gataggagcc aatggactgc tatacactcc ttatttggtt ggtgaaagaa cgccgcatgc 1767241 tgattcttct attcggggaa gcttgatcgg aatggatgga gcccataata gaaagcattt 1767301 tttgagggca ataatggaag gtatcacatt ctctttacat gaatcaattg agctattccg 1767361 cgaagcggga aaatcagttc atactgttgt ttctattggt gggggagcta aaaatgatac 1767421 gtggctgcaa atgcaagctg atattttcaa tacgagggta attaagttag aaaatgaaca 1767481 agggccagct atgggggctg caatgctggc tgcctttgga agcggttggt ttgaatcact 1767541 tgaagaatgt gcagagcagt tcattcgtga ggctgctgca ttttatccaa aggcgcaaaa 1767601 tgttcaaaaa tataaaacac tatttgattt gtataagaac atttacactc acacaaagga 1767661 tctcaataca gctttgaaga gctttcgaaa aaactaatga tgttattgtc tggagatcaa 1767721 ccgaagaaca attaatgatc aatcatcatc aaaggccttt gataacatgg ctgccttctt 1767781 ttgaaaagat ggtgagaata aggtatcgca acctttaaac agtattggag tatccagcag 1767841 acaaaacgaa cgagtggaac cgtattttgt cagcgaacac ttcaagaagt ggggaagctt 1767901 aggaatgcca atgggtaaga tgtatgaaac cgcgctaacg acggtagagg gatctcttga 1767961 tttatgaaga aataggaagg atgttaacac acaaataacc cctcacattg acgtgaaggg 1768021 gtgtttttta ttgttactat acagcggaaa ttttacaggc tagttgcatg attttagctt 1768081 gttaagcaga atggaactag actctccatc atctctttct cattctttgg aaactgcatt 1768141 ctgctaggtt tgctgctttt tttaacaaac agtgtttttc tatttcacac agccattaaa 1768201 tcctctgttc gtcacataac cgctcttact ccaaattgac agtttatctg attttgcttc 1768261 ttgctcatct agtctgaatt ggtctatgta ttttgtgtta ggctcatata catatgctac 1768321 tctggccaat ccctctttca ataatgtctc ttgaacagat ttgccgtcaa cataaacgta 1768381 tgctaacagt cttccatact tatctctgcg atcgccttta tcaaattcca gctgtagctt 1768441 accgctgttg accaattctt tatttcgttt cgacgcatcc tcaccgtatg gttgaacaca 1768501 agaatttggt ttcttcgtct caggtgtatc aacgagcaag tagcgaactg tgtctttctt 1768561 tccgttgtaa ataaccttaa tcgtatctcc atctattgct ctatctaatg taacattgac 1768621 caatttcttc tgattttttg aatgaggcgt gccagccttt tgttctgtct gattatattc 1768681 attagagtga gtatcttgag agacttgctc cgtcccatta gaatctgaat ggtttttggc 1768741 tgcgtgattt gatccgcaag ctgccaaagt aatacttaaa acgattgcga tcatactgat 1768801 caaaatcttc ttcatattga ttccctcttt atcattttct cttttcgcga ttaaacatca 1768861 tcattataac gatatggaca ttttttgtga atggaaaact tcaagggaac ttataacact 1768921 ccaaattgcc aatagttaac ttcacaacga gatgatcaaa acatcaccat cacatagcgg 1768981 aaataaataa tcctgaaaat aatattgact gaaaatgctt ttagaattat gataatatga 1769041 gaaatgacaa taatgtgaca aagacattac tacaacataa caactaatag cttaggttta 1769101 ttctattggt taaaaatgta aacggttaca aatccagagg cgaaaatcta agatagagat 1769161 gactttagtt ttgactcaat atccacactg aaagagctta ttaagtattc ttaaaggcag 1769221 gggaaatgga tatgaatgaa catcgaaatc gaaggttgaa attaataatg atttcagcaa 1769281 cttttggagg gcttctcttt ggatatgaca ccggagttat aaatggagct ttacctttta 1769341 tggcaaggcc agatcagctt gatttaacac ctgttacaga agggcttgtt acgagtattc 1769401 ttttattagg tgccgcgttt ggagcgttgt tatgcggaag attggctgat cgatatggcc 1769461 gccgtaaaat gatccttaat ctttcctttt tatttttcct ggcatcactg ggaacagcgt 1769521 tagcacctaa tgttttcatc atggcggtct ttcgtttttt actggggctg gctgttggag 1769581 gagcctcggc gatggtgccg gcctttttag cagaaatggc accgcatgaa aagagagggc 1769641 gtatggtaac ccaaaatgaa ctaatgattg ttggcgggca atttttagca tatgttttta 1769701 atgcgatcct cggtgtaaca atggcaaata cgggacatgt ttggagatac atgctagtca 1769761 tttgtgctgt accggctatc atgttatttg ccagtatgct taaggtacca gaaagccccc 1769821 gatggctaat ctccaaaggc aaaaacagtg aggcgctgcg agttcttaaa caaattcgag 1769881 aagataaacg tgcagaagct gaatgtagag aaattcaaga agcggtagaa aaagatacag 1769941 cactagaaaa ggcatcactc aaggactttt ctacaccatg gctgcgccgt cttttatgga 1770001 ttggaatcgg tgttgccatc gtgaatcaaa ttacaggtgt gaactcgatt atgtattatg 1770061 gcacacaaat ccttaaagaa tctggttttg gtacaaaagc ggctttaatc gctaatattg 1770121 gaaatgggct gatatcagtt attgcagtta tatttgggat ttggctggtc ggaaaagtga 1770181 gacggcgtcc aatattattg attggtttgg cagggacgac tacagcgctc ctattgattg 1770241 cgattttctc aattgtgctt gatggatcta tggcacttcc ttatgtagtg ctttctttga 1770301 ccgttttatt tcttgccttt atgcaagggt gtgtaggacc tgtgacttgg cttgtcatag 1770361 cggaaatatt ccctcaaagg ttaagaggac ttggttctgg gataagtgtt tttttccttt 1770421 ggatattaaa ctttgtgatc ggttttgctt tcccgatctt gcttagctct gtaggtttgt 1770481 cttttacatt ctttatattt gtggctttag gtgtattggc aatcggtttt gtgtacaaat 1770541 tcatgccgga aacaaaaggg cgtacacttg aagaattaga agagcatttt cgttctcgac 1770601 acgatcataa tactcctgaa caatcagtta ttgaggtata aatatgttga aaatctctct 1770661 tcttatagga gggatttttt tagtttcaga aaaaacaaaa tccctctggt agagggattt 1770721 tgattcagca ttttaagatg ttctacacgt ataatactgg agttgatact ttaaaaatct 1770781 cgccatctct tatataaaaa cgagggatgc ggcggcttaa tgtagacacg acttcatagt 1770841 taatcgtatt gagcatttca gccacttcat caacggaaat ctcggctcct ttttgcttac 1770901 cgtaaatcac gacttcatct ccttgtttac cttcaccgtt ttctcctaaa ctgaccatga 1770961 tcatatccat tgttactctt cccgccactg gcactcgttt tccgcgatga agaacaaacc 1771021 cgcgattgga aagggcacga gaatagccgt cagcatagcc aatcgggagt gtagcaatta 1771081 cttcattagg ttctgcgatg tatgtagcac catagctaac ggttcggggt tctgtccgca 1771141 tggttttcac ataagcgatg cgtgccttta aacttaacgc aggttcaagc ttaacgagat 1771201 ttagttgttt aatataggct gaaggatata aaccatataa gccgatacct aaacggatca 1771261 tatcagcgct aaattccgga aatgcgatag ctgcagccgt gttgcacata tgcacggtgg 1771321 gcagctcaat cccctgtttt tttaaaaagc tgagaaaact gatgaatttt tcatgctgca 1771381 gctttgtgag tgttgtgtcc ggttcatcag ctgtcgaaaa atgtgtgaaa atccctgtcc 1771441 atctgaggaa tttacttgcc tttaaggctt tcactacctc taaaagttct tcctttgtgc 1771501 gtacacctaa tcgtcccatg ccggtatcca cgttaatatg aatggccagc cggttagcac 1771561 tcgcttcttt ttccaatatc tcgtttgctt ctttcatcca atcaacctga aatgctgata 1771621 atgttatatt ccaagctgct gacttcttta cacaactaag ggatgtaaaa ccaagcacaa 1771681 ggataggtgc tgtaatccca gctttacgta aaacgattcc ttcctccaca ctggcaacag 1771741 cgagctcact cgccccgtgt tccagtgcat ggcgtgccac ttctatagac ccgtggccat 1771801 aaccgttcgc ttttacaaca gccataattt tgctcttatg tggaatatga cggcggatcg 1771861 ctcgcaaatt ctttttaacg gcatcaagat tgacttcgat ccaaacttct cggcaaagct 1771921 ttatcatcaa cgcttccttc cttcttatgg attataaata ccacctattg ccgcaagaat 1771981 aaatgttaat tgttggatga ttcgatctta ttttattcaa ctttatttga aatcattcaa 1772041 cagcaaatcc atgtgatacg agaaggtgcc tatcaatgtt cgaataatag caagtacggg 1772101 atacatgagg cttgtaagtg gggtgttaat ggatgcggcg accgaggatt acaaaaatga 1772161 ttatttgttt tgggacattt ttttctaagg gtagatgata acgagaaatc taatcaggaa 1772221 atacttaccg ttgttatgaa cattgaagaa ccttttaaat gagaagggct gaggaaattc 1772281 tgtaaaagat aatcggttga aaaggcagtc gattccttgt tccataaacc taacatcaga 1772341 gtatataatt atactcgtat tcacaaaaat cgtttaagta aggggtatac atgaataggg 1772401 gagttagttt tcaaataccg aatgaatatg gaaattttct atggagaata ctgcagccgg 1772461 tagaaatagc taattatagg tggcaaacga gtggggaatc ttattttgtt gtagaaggag 1772521 agctcgatga tgaggagctt tttcatgact acgaaattgt tgagggggca gtttttgagc 1772581 aacaattaaa aacgaatcag tactatacca ttttcgttga actgaaagca tttccatatg 1772641 gaaaaatggt taatcaagtc aatacatatg aagagtttgc tgacagtgat tgcgaacttg 1772701 tccttttgat agcagataat agctacgttt cgatttactg taaaaacaaa aatatcattg 1772761 aaaaacttta cttcaatgct ttacagcatg attttgaaga cgttcaattt ataactgatg 1772821 aaaatgacac aagaacaagc cttactgtat gatactcaat aaaaattaaa ggagctagta 1772881 catgacaatg caaattaaaa tcaagtatct agatgaaaca caaacaagaa tcagcaaaat 1772941 tgagcaggga gactggattg atcttcgggc agctgaagat gtaacaatca aaaaagatga 1773001 atttaagctt gtcccattag gtgttgcaat ggagctgcct gaaggttacg aagcacatgt 1773061 cgtccctcgt tcaagtacat ataagaactt tggcgttatt caaacaaatt caatgggtgt 1773121 tatcgatgag tcatataagg gagacaacga tttctggttc tttcctgctt atgcattgcg 1773181 tgatactgaa attaagaagg gtgatcgtat ctgccagttt agaatcatga agaaaatgcc 1773241 ggcggttgaa ttggttgaag tcgagcattt gggaaacgag gatagaggag gactcggttc 1773301 aacaggtacg aagtaaacaa aataaatcct tggctgtctt catgctgtgt gattgatcaa 1773361 tggaggtttc agccaaggta catataaata ttatgtataa aatgaatatt ttaatacgaa 1773421 ggatttaatt aaaaacaaag tttaaaaagg gaagttttga aaaagtgaaa tagtaataac 1773481 taaagtcgat aaagaaccta aagatgtcaa agaaacaatt tttctggtgc tttgcttttt 1773541 tgaaggttta cttagctcgt ggataactgc cccccataaa agcatggatg ctaaaattat 1773601 aatacttata tacataaaga tgctcctttt attatattta cagtttttac atttttatcg 1773661 attttaccac atttaggatt gagttgtcga tgaaacaagc atctctataa agaaatactt 1773721 ttatctaaat ttttataaat aggggaaggc aactaaaaac tagtaatgcc actaataata 1773781 agccaagtta aatgacttgt gttcattaat aattgaattt tacagcagcc atgagcacaa 1773841 aaaaatctga gttcgtcgat aaatatcata aaaaagcccc cggtatgtcg ccagggaata 1773901 aatagacgtt taagagattt agtgatgttt tttatatgat tcgacaaaat cataataatg 1773961 atcatcgtca tcataatact ttttttcgta atgataatcg tgatcatcgt aatacttttt 1774021 atcatggtca tcatactttt tgtcgtaatc ataatgtttt ttatcatgat cataatactt 1774081 gtcgcaatca taatgcttct tatcattgtc gtaatacttt ttgtaatatg tttttttcca 1774141 agtataatac tcttctttat attttttata ataacccaat taaattcctc ctttatgtta 1774201 ttcgaattta atttatgaag tttaaatgat atggtatggt caaatgaaat aagaatagta 1774261 aaaagaggct gtttaaaaca ctttctgaaa aacaaaacgg atagctgttt atgaaaataa 1774321 gagcgagaga gagcactcaa tcactgtaaa ataatagtaa agtgtataga gagattagta 1774381 tacgtaaaaa gggactttct cattgaagaa tatttgaacg ttatggttaa gattcaagag 1774441 ctctatgatg tgatttttca cactgctttt gaaggattta gagttagaca tcaaaaacaa 1774501 acagcaaaac cggctagaaa cagatcatat aaggaatgaa ccgctgccaa atatcataaa 1774561 aaagttgtta atgatcaaat gaatgaaatt agagagaatt tattttaaag aaagcccaat 1774621 tgcacatgga caaatgacaa ttgatattga ggtaaaatac aatgcattaa atcagaaaaa 1774681 gctattggag gatttaatgt gtttagacaa tttccaattt ggtatacaca aacacctgac 1774741 tatttgaatt tttatgtacc gcaatatcaa accatttcgt ataatcctca acaatgttat 1774801 caacggtgta tgtaccaaac tggcggtaac tatgagctat gtgacagact atgttatgga 1774861 gaaatacagg tgtaaaagag ggggattaac tcctctttaa acacacagtg agtggaataa 1774921 gatcctcact ttatctgcaa gtgcttagta tttgcgataa tattgcattc gtaataaatt 1774981 atgcttagca actgaaaatg aaagaaggat atgaatagtc atgacgcaat tcgataaaca 1775041 atacaattca attataaagg atattatcaa taatggaatc tcagacgaag agtttgatgt 1775101 aagaaccaag tgggactcag atggaacacc ggcacatact ctaagtgtaa tcagtaagca 1775161 aatgagattc gacaactcag aggttccgat tttaacgaca aaaaaggttg cctggaaaac 1775221 agccattaaa gagttgctct ggatttggca gctgaaatct aatgatgtta atgatttaaa 1775281 catgatgggc gtccatattt gggatcagtg gaaacaagaa gacggaacca tcggacatgc 1775341 atatggattt cagctgggga agaaaaacag aagtctaaat ggagaaaaag tggatcaggt 1775401 agactatctt cttcatcaat tgaagaacaa tccatcttca cgcagacaca ttacaatgct 1775461 gtggaatcct gatgaattag acgcaatggc cttaacgcca tgtgtatacg agacacaatg 1775521 gtacgttaaa catgggaaac tccaccttga ggtaagagca cggagcaatg atatggcatt 1775581 gggaaatcca ttcaatgtat tccagtataa tgtgttgcag cgcatgattg ctcaagtgac 1775641 tggttatgag cttggtgaat atatctttaa cattggggat tgccatgtgt acacacgtca 1775701 tatagacaat ttgaaaattc aaatggaaag agaacagttt gaagcacctg aactatggat 1775761 caatcctgaa gtgaaagatt tttatgactt taccattgat gatttcaagt taatcaacta 1775821 taaacatggg gacaagcttt tatttgaggt agcggtttaa tgctgccttt ttattgtgca 1775881 gtgaatagat agcaggtatc ctaatttcat taagcaatct ggaagatgaa taaaaattga 1775941 aggacaaaca cgtataatac ataaaaaaga ttaactctac agttaatctt ttttattcag 1776001 aagaaaatat cctaactttg aaactaaata caaagtaaaa gcaatcatta cagttctaga 1776061 tattacaatt ccatgaatag ctagatcata tccagcaggt atcaacgcat ttgtattaca 1776121 cataaaatat atagatatta gaagtgctac aataactaaa atcattccaa aaagacttgt 1776181 tttttcatat ttcataccaa tttccaccct tattaaagtt aggtttaaac aaaagagctg 1776241 aagaaacgaa ctatgaccag tatgctccaa ggaaaaccgc cagacaatgc tggcggcttt 1776301 ttgctgcttc gtttatttat taacagagat cgtaacgtta tttcctgcaa ctgaaacctt 1776361 tgcgaaatcc tgtgtatcta ccacaggagt gacggcttta ttgtcgatag tgatgttgtt 1776421 aaaagaggtc gaaaaggttg ctttgatcgc atcacgctgg ctttcatacg aaacagccgc 1776481 ggtagcaagt gttttccatt ttgaaatcgt gccgatgttg gttccttgaa tttctgtgat 1776541 aatccgtccg gtgtagccgt cattgttcgt tccccaaagg gtcatgcgcg tattgccgct 1776601 taaattttta tagattgtca tttggactgt gcttccaggg cggaagcctt tattgtatgt 1776661 gaatttgtct tttccttcga tgtacgtttc ttcatttttg gacccaacct tcatgagggg 1776721 cttccagacg ttgtattgtt tgctgtactg aagcccgata tcggcttcag ttccgcttgt 1776781 tgccctaaag ccagaataaa tatagggagt agagaccgag tcgttgtttt tgacagtttc 1776841 aggaagcacg attttagctg taaaaacggc gcccgtactg ttcaggtaga cacggccgcc 1776901 gattccgtta ggcagctcgg atgctgcttt tgcgacttga gcgtctgccg cgggtaaacc 1776961 tggtatacct gatgaaaggg ttccgaaaag aactgctgtt cctactgcac ctgcaatcaa 1777021 tacttttttc accaaaattc ccccttttga tagtggtttc gccatttatt ataccttatt 1777081 ttggaactgg atttacgtat ataaatcgac aaaatatttc attttgaatg atgtaaggtc 1777141 gaaacgcttc gccaatctga aagctatata cctttatcag aggaaagaat gagatcacat 1777201 tcgttttaac cgatttgaaa ttttcctcaa aataaaagta caaatgctta aagaaacgat 1777261 tattaaaaga atgcccgcta tcgtttccaa gcctgtaaaa aagaggtgac gtttcatcaa 1777321 tgtctgtcct tgtaaaatga taaaagcaca gataccgact aagaaaagaa aacaaatact 1777381 taggattgct aacgctttac gtgagtatgt tttcatttca tctttaaaat acagcaatac 1777441 gaaaataaag cagataacat tggctattgt tctaatcacc tcaaagcttt tcatgacaac 1777501 tgatataaat agacaaagta aaatgagata aaatacgatg tttctataca aaaaacctct 1777561 ccttttatgt aggatcctca aagagtttat aaaagtttct ttgtaactgc aataaattga 1777621 atgcgctcac ttatgaacta actaaactat gtactaaata ttcactattc tttttcagat 1777681 tcagtcacca aggttttcat agaaagggaa gcttcagaaa tatacatata gtgcacaaac 1777741 aaaaaagacc cggcaatagc cgggggaaag taaaaacgag gagatgttaa tggcgtttag 1777801 tagtgttttt tatgcttttt atactctaca acataatcat agtctttttt atcgtgatca 1777861 taatattttt tatcatagtc atcatatttt ttgtcgtaat cacagtcata atctttttta 1777921 tcatattcgt aatacttctt ataatacgtt tttttgaccg tataatactc ttctttgtat 1777981 tttttgtaat aacccatata tactcctcct ttatttttac tacgctttat tatacggcga 1778041 gtagattttg cggcttggac agttaaaatc atagaaggaa aaaagggctg tccaaatgat 1778101 agaaaaagac agatgacaca aaaacaaatc aaaataaaga gccgattttt catcggccca 1778161 aacgatttat cctacatttg tttgtcttct ttgttttctg agtcattttt tctgatatcc 1778221 tgagtcagtc cgcttgttgc ttgtttaaat tctgataagg cttttcctgc tgcacggcca 1778281 agcgccggca gtttatcagg cccaaatact aaaaaaccca caaacaaaat aacgagtatt 1778341 tttgtgaagc ttaattccat atccttttcc ccctgattga agtacaacct tttaaacaaa 1778401 ttataagaga tagcagtaca aatgggaatg catttatttt gaacatttta aaaccagcac 1778461 aaagacggat tcataaaacg gctgctgctg aatataatgt ccaatgccac ctgcctaaga 1778521 agcaggaggc aggctggatc aattatgtag ctctgccgga aatgatacaa acgtagcggc 1778581 tatcattgac atagaggagt ggtgtagctg atgagattca ctaaggtagt tggatttttg 1778641 tctgttttag ggttggctgc ggtttttcca ttaacggcac aagcagaaaa agccggaact 1778701 gcgggggctg gagagtggga taagttgggg acttacacat atacttactc aagtccgacg 1778761 gtatactcga ccggaggaga ttttagagtg tgcctttcag gaagcactcc tttttctgtt 1778821 tcactgcact tatatgagga tgatcccggt gacaatcctg atgattatgt aggggcaaac 1778881 tatttttcac ccggagaatg ccacaccttt ggcagtattg gaaaatttgt agatgggagc 1778941 aataacaagg ccgagttctt tgttaccgat tactctggta aatctaaaac tgttacgttt 1779001 tatgattgat ggactcaaat tgtgaagtat aacccttgga aaaaaacaaa aaagagagat 1779061 acctctctct tttttattct tcgacagcct tacgaagccg ttcatttaca atgccagtcc 1779121 agccgccatc catcttaccg cgaacgacgg agcttttctc gtttgctttg ccgatcactt 1779181 cattcggctc tttccagccg ctgtgaataa gggtaaaccc tgtcttttcc cccaagtctt 1779241 ctaattgaaa ggtaacgacc catccttctg tatcccattc aaaagaaagt tcagttggag 1779301 cttgaacagc caaaacttta caaggggacg gcccaaacgg cgattgtaag tgaaattctt 1779361 gtccttcttt gagctgaaag tcattgggca taaaccactt ggcaatgcct tctgaagtag 1779421 agactgtctc ccagactttc tgaatgggag cctccagagt aatgcttttt gtaatatccg 1779481 gtaatgcatt ttcgttgttt tgagccattt cgtttacctc ttgacatatg atgttttttc 1779541 aattcaatca tataataact aataagatca tgtccatagc gtgcattatt tatgctagag 1779601 ctgctgttga acagcgtgtc agtcgccagt ctgatctgtg aatgggagaa ttctgcatgc 1779661 gcgaaaaaga gagagaggtg tatgttgtca tttcgttcat tcttgtttgc agccgcaact 1779721 gttatgtttg aactgggatt cctgttcagc caatttattt tgcgattttt gttttaatag 1779781 taaatgagcc attttctaaa acaggaggtt ttttatgctt ggaaaaatca aagcagccat 1779841 tgataatagt ccagggaagc cggccagaat tttagttagt gaaaaagcgt ttcagcaatt 1779901 agaggaagaa atgcgctttg tttacgtttc caaaccgaaa acgataatgg ggattcctgt 1779961 ggaagtttca gatcaggcag aaagcttcaa gctggaattt tagttttccc agactgctaa 1780021 aaggctcatt ttgtgttaat tatgcaaaat ggtcaggttg atttctttaa aagcatgatg 1780081 aaatgttcat catgcttttt tattgagaaa aaagacgaac ataaaaaata ggtatacggg 1780141 aaaaataatc ctattagaga gaggggaact gacagatgga taacatgata tcaacactta 1780201 ctgactggaa tgtgtggttt caagcgttag tagtatttct cgttccatat gtaatctata 1780261 aagtgtttac ttggattcat gtataagaag gtgcaatgat gaggtggcgg aacaatcagt 1780321 acaaaacaca gaagcagcat aaatcagatt attcgacagc tgaaaagcag gatcaggatg 1780381 tgttaaccgg taacatcgga tacgacttag aacatgtaaa aagaaaaata ggacataacg 1780441 gggacgttca tttccgtgag cttgaaatca ctcaattaca tgtgaaagcg gcattgatct 1780501 ttgttgaagg actgtctgat caggacttga ttaataaagg actatcagtg ttagtcatga 1780561 atcaacctaa tcaggtaagc gatgaaattt ctcaatccgg caaaggtatt ttaacttcga 1780621 aacagataaa aaatcaaatc gtatcaatcg gtgatgtcat agattcagag aaaatcagtg 1780681 atatcgtgtt gaatgttttc atgggttcga cagcgcttct catcgatgga ataccgcagg 1780741 cctttcttct gggaactgta aaaaaacaaa atcgaagtat cgaggagccg ctttcagaag 1780801 cgcttgtcag agggccgcgc acaggcttta cagaagagtt gagtacgaat acagctcttt 1780861 tgagacagca aggaaaaaat gatcaattaa cattgcagag atttgaagta ggaacacgat 1780921 taaaaaagga tttaattatc gcttatatga atgacattgc agatccaaaa gtagtcgagg 1780981 aagtaagaaa aagagtgaga gggattgaga tcgatcattt gccggagtca ggctacgttg 1781041 aacagttaat tgaggataat tatttgagcc cgttcccgca agtacagagt acagaacgtc 1781101 ctgatcgcgt cataagcgga ttaatggaag gaagagtagc tattctgctt gacggcactc 1781161 cgtttgcttt gattgttcca gtcactttca gcatgatgct tcaatcgcct gaagattatt 1781221 atgaacggtg gttcccgagc tcgctcatca gattgctgag gttcatcgca gcaatgataa 1781281 cgttattcgc acccgcttta tatatatcat ttatttcttt tcatcctggg ttaattccga 1781341 ccaagctggc gatttcaatt tccgggacgc gccaaggtgt tccgttccca tctctgattg 1781401 aagccttatt tatggaagtc gcgattgaaa ttttaagaga ggcggggctt cgtttgccaa 1781461 aaccaattgg acccgcaata ggcatagttg gcggattaat catcggggaa gcagctgtgc 1781521 aggcggggat tgtcagtcca atcatggtca ttgttgttgc gctcacagca atttcttcat 1781581 ttgccatccc gcattatagc acaggtatag cacttcggat gcttcggttt ggcgcgatgt 1781641 tttgtgcggc ggtgtttgga ttgtttggag tcattatgta ttatctgctg ctaagcagcc 1781701 atgtcgtaaa gctaaagagc tttggtgtgc catacgcaag tccggcagtg ccctatcact 1781761 taaaagattg gaaagacttt gttatcagaa tgcctctttt agtcatgaag cgccggccta 1781821 aaatgatgaa tacagataat acaaaacggg tgaagtgatg aactcgacag gatggtgata 1781881 aagtctcatg ttcagcccaa ccagtaaaat cacaaccgct caggcaacga ttatcatcat 1781941 taattatatg cttgctgccg gagttcttac gctccctcgg acagtaacag aacaaacaca 1782001 atctcctgat ggatggattt cagttttatt aggcggggtc ctagcggtaa tagccgggat 1782061 gattatagct aaattaagcc agcagtatcc taaggagacc ttttatgaat actcccgaca 1782121 tattgtagga aaatggctcg ggcatctgat cagtattgtt tttattactt attttctggc 1782181 actcggtgca tttgaagtca gagtcatgtc cgaaatcgtg gatttttttc tcctcgaagg 1782241 gacaccttct tgggccatca ttatgacagt tctttggatt gggctttatt caattacaca 1782301 aggcctagat ccgattgcac ggctttttga aatgattttt ccgattacgg tcatcatctt 1782361 tttaacgata gccctcatga gtttaggcat atttgagatc aacaatttgc gccctgtatt 1782421 aggtgatgga atcatgccgg ttcttagagg tgtaaagaca acgaaccttt catttacatg 1782481 ttcagaaatt atgttcattt tagtagcatt tatgaaaaag ccgaaaaatg cggtgaaagc 1782541 agttgtgatc gggacaggcg ttgtgaccag tttttatatg attacgatga ttatggtcat 1782601 cggtgcacta tcagttgagg gagttgtgac gagaacatgg ccggggcttg acctgatgag 1782661 aagttttgaa atacctggtt taatatttga acggtttgaa tcatttctgc ttgtgatttg 1782721 gattatgcag ctttttgcca cgtttattat cactttttat gcagcttccc tgggagtctc 1782781 acaagttttt aaaaagaaac ccctttcatg tatgtttggg ctgcttcctg ttatatatat 1782841 cctctcttgc atgccgaaaa atgaaaatga cgtctttata ttgggcgata cggtcagtca 1782901 tatcgctttg tatatatttg gcgctttgcc gattttgctg ttagtcattt cgaaatggag 1782961 gaaaagaggt gaaaagtaaa ctaaaacgtc aattgcctgc tatggtcata gtatgtctgc 1783021 tgatgatttg cgtaacagga tgctggagca gtcgggaaat agaagatctg ggtctcacat 1783081 tcgctatcgc aattgataaa ggaaaagaaa cgaacactga aaaagagtta aaagaagagg 1783141 gcgggagcta tccgaaaaaa gacaacatta cgctgaccta tcaatttgtt aatgaaaaag 1783201 cggcaggcgc gggcacaagc gggggaggcg gtagcggaca aggagcgcaa aaagcgtaca 1783261 ttaatataag tgaaacaggg gattcattac agcagatcgg aagtgaggtt gcattaagac 1783321 gggaccgaga agtgtttagc ccgcatttaa aagttgttgt catgagtgaa gatgtgctgc 1783381 acacatttcc tatcgacgaa atgctggatc aattttttcg tgataatgaa atcaggctga 1783441 gctgtcttgt tttatctgct aaaggggaag caagagacgc tctccagctg aaagagaacg 1783501 gagaaattcc ggcatttcgg ctgattggat taggtgaaaa tgaacataaa gtttccagaa 1783561 ttcttccccc tatgacactc gcgaaactaa ttggaaaact gcattctggc agcagctttt 1783621 tactgcaaaa tgtggttgcg gcgaatggag cggtcaagta ttccggagca gctgtaatca 1783681 acggaaaatc gaaaaaaatg ataggcacct taaatgaata tgaaactgag gggattacat 1783741 ggattagagg agaagggaaa ggcggagttg tcaaaagtca tgataaaaag agccaacaga 1783801 cgttagcgta cgatatcaat aaaatcaaaa gcagaattca gccaatcgta aaagggaaag 1783861 atatttcatt ccatgtcgat attgaatcag aaggcgattt ggttgaaaac tggaacacaa 1783921 aagaggcgtt ggacacccag tttatagatc gtctcgaaac gactattgaa aacgaggtaa 1783981 agaaaatagt tggtcaggta ttaaaaaaaa ttcagcatga ttataaagca gatgttgcgg 1784041 gttttgatga atcttttaga cttacatatc ctcacttatg gaaaagggtg aaaaataact 1784101 gggatgacac cttcagtaaa gccgacatca catacagtgt gaacgtcaca attactcatt 1784161 tcggcacggt taaaactcag taatgaatcc caaggaagag aaggaaacct ctcttctctt 1784221 ttttatgcat ttattaggat aaagatactt tttttggaga gatatacact tttcaaatcg 1784281 accaatatgc taatatagga attgcttgaa atagaaggga gaaggggctg tgaggcagaa 1784341 accgatttat gtagaaatcg aaatgaaatc tgatctggat acactctggg aatatacaca 1784401 aaacccatca ctgcataagg aatgggatct ccggttttca aatattacgt atttgaatag 1784461 tcagccatgc gaaaaacaga agtttcttta cgaaacaagg gtaggctttg gattaaaggt 1784521 gtcaggtaca ggagaaaccg tcggtgtttt caacaaatgt tcatctgaaa ggtcttcttc 1784581 actggctttt ggctctgatc atccattatc tctgattcgg catggaagcg gctactggaa 1784641 gtatatacag agagaaaatg ggaaaatgac gtttttaaca cagtaccaat acaaaacagc 1784701 ctacggactg ctgggaagat ggattgatcg tttattattt cggccgctgc ttggctgggc 1784761 gactgcctgg agctttgatg cattaaggct ttgggtagag caaaataaac atccgaagcg 1784821 cttcattcga tctgctatca tctatgtgtt catgtgtctg tttttcagcc tgttttggtt 1784881 ctatcaaggc tttgcaggtg ttaagacaag catattgaca ggaacagcgg agataggctt 1784941 agctattttg tggctgcttc ctttaaaaag aaaatggatc attcatggtg tccaggcttg 1785001 tatttttgct gggtttgctt gtctaggttc cgaaatattc atgtgggttc tattgagtgt 1785061 gttttccgct gcaagcggcg ctcttagcct gcagctcccc agtgccaggc gcacaaaacg 1785121 aaagagaaag aagtgacatt gtgagttcga tttatgaaaa atcaattatt aactatcatt 1785181 tgctgcatcc caagctgcag aaacggtacc aattagacgg gtctcataca ttcagcggga 1785241 cgggaacgat gtcagaaata agcggaggct cttttctggt tagaatgctg ttaaagctgg 1785301 gtgttttttt cagatgcttc ttttcagaaa gaggcaaaga cattccattt acaatacaaa 1785361 atagaacttg tcttttgaaa tcgcaacata caggaataga atggaatcgt acatttttct 1785421 ttaaaggcaa aaaacgtttc tttgatgcgt taatgatata tgacgagaaa gaaaatagaa 1785481 tacttgattt cttcggcaaa cctcatctgc tgctgtctgt tttgacgttc gaggcatctc 1785541 ttgacggctc tcttacgatc acatcgggaa agcaatggct attgatatgc ggaaaaagaa 1785601 tcccgctgcc gaaatggctg accggtacat ccgaagtttg cgaaacgttt gatgaaaaaa 1785661 agaattgttt caccattgaa gtgcatgtgc aaaatacaat tcttggcact cttttctttt 1785721 ataagggaac gtttcaggag gaagagagag aatcatgaaa cgaaatggca tagtcagtgc 1785781 gctttgtttt attggatttc ttgcagcaga agcaccggat atttcagtgg cagaggcact 1785841 cgttttgtta tccattctat ttttcgtgcc gggaattttt ccttttgttt ttcgtcaatc 1785901 tccggttcgt gctgctcagt ttatggaaaa cgggctaatc cagtgctatc ctgtagccgc 1785961 attctttgcg gtgctggctc tagtgacgga ggttgggggt ttcgcactta tctggtggat 1786021 gtacacagtt tttaatgcat tgtatgcgat cctccgcctt tgggaaacaa agatacatag 1786081 aatcgaagag acatcagttt tgttcggtct tatttatttg gcgggaggag gattttggtt 1786141 ttttgcttat gctgcccatt tgcagatcat gcaatttggc cctctcatca ttttgctgac 1786201 tgctgtccac tttcactatt ctgcttttct gatcccgatc ttcaacggtt tactcggcag 1786261 aaccattaga aaacatcgga tgttgtacag ttggataaca tgggtgattt tgctttcgcc 1786321 ccttcttatc gcactgggca tcacatattc aaaaacactt gatgtcattg cggttagcat 1786381 ttatatggcg gcgatttatc ttcatgcatt tttggtgttc acggcagctt ttcgcaccaa 1786441 gacggggaca tttcttattc ggctttcttc cgctgtttta atgataacga ttgctttctc 1786501 gatgatttat tcatttggtg tctttcggca agaagttaca ttgaccatca atcagatgat 1786561 ttggattcac ggttttgtca acgcgtttgg tgttatcttg cccgctctca tagggtggag 1786621 aatagaggat gcgaaacctt ttgatgcaga cagtgtaaag acattcagcc gtatctacgg 1786681 aaaaagaaag attggagaag aatttttagc taacattcaa gctgaaaata acgctcggta 1786741 cagcggactt gtggatgata tgggcagcct gcgttcaaaa gatttttcac cagaaaaact 1786801 ggcgccgctc attctttcgt tttatgaaca aaccatcgaa tacaatatta aagcaaaagt 1786861 aacatggagc acgtggtttc ggccgcttgc aattatttac gaatggttca gcagaagaat 1786921 cggccaaata catctttcga cgaaccctga ctggtatagg atgtacagca agataaaagg 1786981 tgttcattcg aaaaaagacg gaagggaaag agtacgtgcc tggattagaa caaatgaaaa 1787041 aaacgaaacc atttttaccg ctctttattc agtgtatcgt tcaaatggag aggggtatat 1787101 gaatatttct ttaccgcttc cattcagcag catgacaggt attttaaaac catatcatca 1787161 tcaggagaag ctggttttaa caagcaggcg gagaaaaagc agagcggggg atgaggggat 1787221 ttatctgcaa acaagagcgg gaacttgtcc gcttccttta tctgaaacct ttctgataga 1787281 agctgtacat gacaacaaat taaccgctgt tcatcatatg tggctgtttg gaataaaatt 1787341 tctaactgtt cattacagca ttacacatat taaccagcct attgaaagaa cctaacacaa 1787401 agaagaagct tcgtctgcca gttgtaatga gatgaactgt tttaaaattc tgcaccgcat 1787461 caagacagga aaggaagggt ttatggtgtt ttatatcagt ttatttctga ttctttggct 1787521 ggctgctggg tttgcagtgg gaatgaaaca agtgtatgtc gatcagctgt ttgataaagc 1787581 tgtgatcgaa agactggaaa aagaagcgaa tgatcatgga catgctgacc ggatgatcaa 1787641 acagcgcgtc ctttatattg cagcagtgac agtaagcggg tttatttctg tttattatga 1787701 aatgaaaaca atcccgcaaa ggcgaaacat aagaaaaatt gaaaaaaaca tcatgaaatt 1787761 aaatcaagca aaaaaacgaa gaatgaagag aaaataaaaa gtgcacaggc caaagggcag 1787821 gtgcattttt gttttgtatg gaaaatgggg gaggtggtgc cagcttactt ttcataaatt 1787881 caaaaatgag aagaacagcg cccgggctaa tggtatataa tattgtgaat ttaacaaaaa 1787941 tttaacaagg aggacgagag aattcgtgct aaagcctcaa agagacctac attctgttga 1788001 tttggactta gaggcggagt agatgaaacc ggccaaagta tccctgctcc gccgtttgct 1788061 ccattccttg aagcatgttg attgtaacat agccaaacgt tttccatcaa ctattaaaat 1788121 tgtaaaatta ttgatgattt ttatggtgtt tactccgatt tcttcaattt atgctgaaga 1788181 tgtatatcag aattttgagg aattaaaaaa caatgaagat ccttctgatt atggcgttgt 1788241 tacgaaagaa accggaagcc ctgttcttgt tttagctatt cacggaggag gtattgaagg 1788301 cgggacaagt gaagtagcga gagagctcag caaagagtac tcgatgtatt tatttgaagg 1788361 cttaaaatcg gcaggaaact cagtcctgca cattacgagc acacactttg atgaacctcg 1788421 ggcccttaaa atgacgggaa atcatgaata tgtcatttca ttacacgggt acgcagaaga 1788481 agatcagcag atcgaagtcg gcggtacaga tcgcgtaaga gcggcagatt tagttgagaa 1788541 attgcagcat gccggttttc ctgctgtatt gctcaatatg gaccatccgc atgcgggcgt 1788601 tagtccgaat aacattgcaa ataaatcaaa aacaggttta agtattcaga tagaaatgag 1788661 cacagggttt cgaaagtctt tgttcggcat cttttcttta aaaagcagag ctgttactca 1788721 aaatgagagg ttttatgagt ttacagaagt gatgttccgt tttctcaaaa atagctactg 1788781 aaaaatagga ggcgataaga cagcctccta ttccttatgc ttctctttcg tttcgggaaa 1788841 cagctcgtcc gcggcttccg tttgatactg caacgtgtta tctctcgctg acagttcatt 1788901 tcggaaattt tcatcaagca catttttcag taaataccga tgaaaaaagt attcaaaaac 1788961 agtaagacag gcagcggaaa ggagagccgc tccaaatggt gagaaatcgt ttcttgtttg 1789021 ggttaaaaca aatacccaaa gaataacgaa tgaaaggcca aagtcagcca atgaagctgt 1789081 aatattgttt gttctgggta agacgagcat gtcaccagaa agataggaaa caaaacctaa 1789141 gaaaagtgca ataaacatca cacttaaaaa ggatgcgtga tagactctgt ccaaaatcac 1789201 atataaaagg gcgagagtga aagcaatctt tgaagcaagc gcaatgatat gtttcatttg 1789261 accacctaaa ttgttatttt ttgaagaaaa ttcttgggcg taaacaaatg ataaataatg 1789321 caattcaaaa ccattcataa tggtcatgtt actattttaa acagtccgtt tttgtttaca 1789381 ctggtatttt tttcagctgt atgaaacttt cttatgaaaa aagtcgtata tgtggatgat 1789441 cagctttcaa ggggggaatg atttgtggag ataaaaggaa tcaatcactt gctattttca 1789501 gtttcgcatt tggatacatc gattgatttt tatcaaaaag tgtttggtgc aaagcttttg 1789561 gtaaagggaa gaacaactgc atattttgat atgaacggca tctggctagc gcttaatgaa 1789621 gaaccagaca tcccgagaaa tgacattaag ctttcttata cccatattgc ttttacaatt 1789681 gaagatcatg aatttgagga gatgtcagct aaattaaaaa gacttcatgt caatattctg 1789741 cctggcagag aacgagatga acgcgatcga aaatcaattt attttaccga ccctgacggc 1789801 cacaaatttg aatttcatac cggaaccctt caagacaggc ttcgatatta caaacaagaa 1789861 aaaacgcata tgcactttta tgatgaaacg gccttttgat agcacaacca tatttcatat 1789921 aaggttaaat ttaaagaagg gtgttggtgg agactttatg tttggggaag gtttctaccc 1789981 gacttgttca acgatgccat atcttttgaa ctgcacaagt gattgggtga aggtgaaatt 1790041 gaaatacaca ttacattaca ttttatatga agaaagcgag ctgttttatc aaatgttgaa 1790101 ctaattaaac tatgtactaa attttcagta tatttcaatt gctttgcccc ttaataaata 1790161 taaaaccgca tccttccacg acctaaaaaa tgaaacgttt ttaagaagat ggcgtctaat 1790221 attctaaatg ttcatatttt gataaaagtt tcctaaagga aagaaaattt cttgacttca 1790281 acaatctttt ggtggataat tatggtgtaa acatgatgtt ctttttcctc ctattcgggc 1790341 tcgcacccaa aagtcagggc gagcctgctt tttttgaaca acaaaccccc tctccgtaaa 1790401 ggaagagggg gttattttat gcatctgata gatcaataga ttaatggacg gttctgaaca 1790461 cgccaatcac tttccctaga atgctgacat tctgcaaaat gataggttcc atcgttgggt 1790521 tctcaggctg caagcgaatg tgggtatcct ctttatagaa tcgttttaca gttgcttcat 1790581 catcttctgt catcgcaact acaatttccc cattgttcgc tgtgttttgc tgtttaacga 1790641 tgacatagtc cttatcgaga ataccagcat ctatcatact gtctcccata atctccagca 1790701 taaatacatg ctcgtctgga ggaaccatgc ggtcagggag cggaaaatat tcttcaatat 1790761 tttctactgc tgtaatagga gatcccgccg tgactttccc gatgaccggt acattaacga 1790821 cctggctttg cggaatgtct acttcttcat caagaatttc tattgctctt ggttttgtcg 1790881 gatctcgtct gatcagccct tttgtttcca aacgggccaa atggccgtgg acagtagaac 1790941 tggacgcaag cccgacagcc tctccgatct ctctcacgga aggcggatat ccttttgatt 1791001 taacctctgc tttaataaaa cggaggatat caagttgcct ttttgatagc ttcgtcattt 1791061 ttcgcacctc aaaacgtcga ttttaagaag attatagcat gattttcctt acagtacaaa 1791121 cataggttcg aaaaaacaat tgacagaaac gtttgttcgt atatactgaa attataaaaa 1791181 tgcgaacaaa cattcctgtt ggaggttatg atcatgagta aagaatctat tatttttgtc 1791241 ggtctgttta cagtgatttt gagcgcggtt atccttatgc tgtcatatac aagcagcggc 1791301 caagagctta atcagtatgt taaaatagaa gtccagcaag gcgacacact ctggtcaatt 1791361 gctgatcagg tagccgatac aaaaaagata aacaaaaatg attttattga atgggtagct 1791421 gataaaaatc aacttcaaac ctctgatatc cagccgggtg atgagttagt gatcccattg 1791481 aaaaagaagc atcaggatgc atatgaatta gcaactgtaa gatagagagg aaagagagat 1791541 aaaatgaaag cactcattta tgcccgtgta agcacaaata aagaacagca ggaaacgtca 1791601 ttaaagcggc aggaggagga gcttacggcc attgcagcgg agaacggcat ggaagtggtc 1791661 aaagtgattt cagaaaaagc cagcggatat gaaatggatc gggatggtgt atttgagctg 1791721 ctcgatgaga ttaagaacgc tgatattgat gtcattttgg ttcaggatga gacaaggctc 1791781 ggacggggaa acgcaaaaat cgcactgctt cattgtattt atagagaagg tgtgaaagtc 1791841 tatacaacgg ctcatagagg tgaactggag ttatcggagg ctgactcaat ggtcttggaa 1791901 atcgtcagca ttgtggaaga gtatcagcga aagattcaca acatgaaaat cagacgggga 1791961 atgaaacgtg cagtaaaaaa cggttttaaa ccgcaaaaaa acttaaaaaa ccaacatggg 1792021 aacagtggaa aagaaaaaat agaggtgcca atctcagaga tcgtccgcct gagagcgaat 1792081 aaactgacgt ttgctgaaat cgcggctacc ctaagagggt ttggctatga tgtctctaaa 1792141 gcaaccgttc accggcgttt tcaggaatac atagagaatg aagagactgc agagtgaatc 1792201 agttgtaaaa ctttttttga tctagtacta tatagacaaa atgcaataaa ggagtttaac 1792261 atgatttcaa acgcgaaaat tgccagaatt aatgaacttg ctgccaaagc taaagctggc 1792321 gttattacag aagaagaaaa agccgaacag caaaagctcc gtcaagagta cttgaaaggt 1792381 tttcgttctt ctatgaagaa cacgttaaaa agtgtgaaaa tcattgaccc agaaggcaat 1792441 gatgttacac cagaaaagct aaaaagagaa caaagaaata acaaacttca ctaatataag 1792501 aggaatacgg caatatcgta ttcctctttt gcatatacta taatcaaaac tcttatgtga 1792561 caaaattcaa caagtttctc tcaaatttaa gctgaaacag ttgagaaaaa gtcgtcagac 1792621 atttatgatg taagggtaca acacataagg aaggggattt ttatggatac aattgaaaag 1792681 aaatcagttg ctaccattcg cacactgtca atagacgcta ttgaaaaagc aaattctggt 1792741 cacccaggga tgccgatggg agccgctcca atggcataca cgctgtggac aaaatttatg 1792801 aacgtaagtc cggcaaaccc tggctggttt aaccgtgacc gttttgtttt atctgctgga 1792861 cacgggtcag cactattata cagcatgctt catttaagcg ggtttgatct tagtattgaa 1792921 gatcttaagg gattccgcca gtggggcagc aaaacaccag gacatccgga attcggacat 1792981 actgccggtg ttgatgctac aacaggtccg cttggccaag gaattgccat ggcagtcggt 1793041 atggcaattg ctgaacgcca tttagcggaa acatacaacc gcgattcatt taacgtagtc 1793101 gatcattata catacagtat ttgcggtgat ggtgatttaa tggaaggtat ttcttctgaa 1793161 gccgcttcac tcgcaggcca tcttcagctt ggccgtctga tcgtactata cgattctaat 1793221 gacatctctc ttgatggaga cctcgaccgt tcattctctg aaaacgtgaa acagcgtttt 1793281 gaagcaatga attgggaagt tctttatgtt gaggatggaa acaatattga agaattaaca 1793341 gcggctatcg aaaaagcacg ccaaaatgaa aagaaaccta cattaattga agtgaaaacg 1793401 acaatcggat tcggttcacc taaccgtgcc ggtacatccg gtgttcacgg tgcgccgctt 1793461 ggtaaagaag aaagcaaatt aacaaaagaa gcttacgcgt ggacatatga agaagacttc 1793521 tacgttccgt cagaagttta tgagcatttc gctgtagctg ttaaagaatc aggtgagaaa 1793581 aaagaacaag aatggaatgc tcaattcgct aaatataaag aagtttatcc tgaacttgct 1793641 gaacagcttg aactggcaat caaaggagag cttccgaagg actgggatca agaggttcct 1793701 gtgtatgaaa aaggaagcag tttggcatcc cgtgcatctt ccggtgaagt tctcaacgga 1793761 cttgcgaaaa aaattccttt ctttgtcgga ggttctgctg acctagcggg atcgaacaaa 1793821 acgactatta aaaatgccgg tgattttaca gcggttgatt actcaggcaa aaacttctgg 1793881 tttggtgtac gtgaatttgc gatgggtgcg gccttaaacg gtatggcgct tcatggcggt 1793941 cttcgtgtat tcggcggaac tttctttgtc ttctctgatt acctgcgtcc tgcgattcgc 1794001 cttgcagcgt taatgggcct tcctgtgaca tatgtcttca cacatgacag tattgcggtt 1794061 ggtgaagacg gtccgacgca cgagcctgtt gaacagcttg cttcactccg tgcgatgcct 1794121 aacctttctt tgatccgtcc agcagacggc aatgagacag cagcagcatg gaagcttgca 1794181 gtgcaaagca ctgaccaccc aacagcgcta gtgcttacac gtcaaaacct tcctaccatc 1794241 gatcaaacat ctgaagaagc attggcagga gtagaaaaag gtgcatatgt cgtttctaaa 1794301 tctaaaaacg aaacacctga cgctcttctc atcgcttccg gatcagaggt aggtcttgca 1794361 attgaagcgc aggctgaatt ggcaaaagaa aatatcgatg tttctgttgt cagcatgcct 1794421 tcaatggacc gttttgagaa acaatctgat gaatacaaaa acgaagtcct tcctgcagat 1794481 gtgaaaaaac gtcttgcaat tgaaatgggc tcatcatttg gatggggcaa atacacgggg 1794541 cttgaaggtg acgttctcgg catagaccga ttcggtgcat ctgctcctgg tgaaaccatc 1794601 attaacgaat acggcttctc agttccgaac gtagtgaatc gagttaaggc attaatcaat 1794661 aagtaagctt ttgaaagagg atgagtcaaa tcatcctctt tttcttgttt atccgacaaa 1794721 aatagtattg gctgtttaac agtaatagac aattctttct tttcttcttt tgtataatag 1794781 agagcaaatg aaatgctgct ggaaaagggg atgaaaagat ggaacgtcac tactatacgt 1794841 acctgatcaa agaggaattt gccaatcact atttcggccg ggaatcggtt atgtttgagc 1794901 tgtttcaaga ctatcattgg acaagccttg aaaagcagca gtatgaaatg acagagaaac 1794961 agattcaata tattacacaa ccaatcccga ttttacatat gcatcagcgg ttaaaaatga 1795021 atttaaacaa gacggattac aggcagctgg attatattta tagaatagct ttgccgaaag 1795081 caaaaggcca cgcgacgttt atgatgaagg agcacatgat agaaattgtg gcttcgggag 1795141 attacgaggc agaaacgata ttctttgaag tgttaagaaa agtaagccct tgctttttag 1795201 caatggattt caattcgaag cgttacggat ggctaaatcc ggtgaaagaa agaaattttg 1795261 tctaaaaccg aagaaaaaga gatgtaaatg ttgtataata gcttttggtt tagtacactt 1795321 taaactagac aacatgaagg aggaaataaa atgactttat gggttggcat cctagtgggc 1795381 gttgttgcat tgctcatagg tgttgcactc gggtttttta ttgctcgtaa atatatgatg 1795441 agctacctga aaaagaatcc gcctattaat gaacaaatgt tacgcatgat gatgatgcaa 1795501 atgggaatga aaccttctca aaagaaaatc aatcaaatga tgaaagccat gaataatcaa 1795561 acgaaataat acgtaaagat tatgatatag agaaacatgg ttataaaata aaaaaccctt 1795621 atacgggttt tttattttgc aatcattcat cacccgctac tgctcgaagg cgctgctttt 1795681 gatattgtat gagaagatgg tcaagctcct gactgagctc tatcgtaata tgagatgtca 1795741 ttccgttcgc catgacaatt tgcagcagct ctgctctttt tttttcaatt tcttttaata 1795801 gatgctctct aatcacaggg atgtatcctt tcatacatta gatcttcaaa gtgaatgttt 1795861 atattatatc catatttata ctaattttca aatgagaagg agtataatgt ctcaatgtca 1795921 aattaaatta tataagtttt ttctgaaaat agaaatcctt caagtgaaag tgttaaaaaa 1795981 atgaaatgat tttgtcataa cttgaaggaa tgtcaaatca tgaagggatg atgacatggg 1796041 agacgtgaat tattttttga cattcggagc ggggttttta tcctttattt cgccttgctg 1796101 cctgccgctt tacccagctt ttttgtcata tattacaggg gtcagcatgg acgatgtaaa 1796161 aactgaaaag ctgctgctgc agaaaagaag cttgtttcat actttgtgtt ttttgcttgg 1796221 cttttcagtc atttttattg ctttaggcta tggaacatct tttattggca gcctgtttag 1796281 ggattatcac gatgcgattc ggcaaattgg cgcgttgctt attattttgt tcggtttcat 1796341 tacactcggt gtgttccggc ctgaggctat gatgaaagag cggagaatcc attttaagca 1796401 taaaccaagc gggtttttag ggtcggtctt aatcggaatg gcatttgcag ctggatggac 1796461 accatgtacc ggtccgatat tagctgctgt tatcacactt gcaggcacca atccgggctc 1796521 agcggtgcca tacatgatgt tatatgtact cggttttgcg gtaccgtttc ttttattgtc 1796581 tttttttatc acaaagctga agtggataag gaagaaccag cttttcatta tgaaagctgg 1796641 tggcgttttg atgattgtga ttggtgtgct gttattcttt aattggatga gcctgatcat 1796701 tattttgctg tcagatcttt ttggaggctt tactggtttt tgacggtaaa ttactttcgt 1796761 actactacta atccttttgt ttttggtaca ataagactat tatctgtgga aatcgattgt 1796821 tggaggggaa tatgacaaga gttttagttg tagacgacgc caagttcatg agagtgaaaa 1796881 tcagagagat cttggaagag gcaaattaca taatcgcagg cgaagcggcg gacggtgaac 1796941 aagcagctga cctgtataaa aaactgcgcc cggaccttgt gacaatggat attacaatgc 1797001 cggtgaaaaa cggcataaaa gcgcttcgtg atatcttaac ctttgatcct aaagcgaagg 1797061 tcatcatgtg caccgccatg cgccagcaaa gaattgtaac ggaagcaatt gagctggggg 1797121 caaaggattt tattgttaag ccgtttgagg aaacaaaagt gctggaagct gtaagccgcg 1797181 ttatgggaca ttaaagtcat ttcttttcaa aatggttttt tttattgttt tggagtatag 1797241 tatatagtat caacactccg agaaacaaag gaatgataag tatgatgatt atagtttcat 1797301 caattattgc tgtgttaatg gctgtagctg tgatggtggt cagaataaag tcctctgaca 1797361 agcctgtttc accaaaaaaa atcattcttc cgccgatttt tatgagtacg ggagcgttaa 1797421 tgtttttatt tccggtattt tgggtaactg gagcagagtt tttggaagca ttcactttag 1797481 gtgtgatttt ctctattttt ctaatcaaaa cttctaagtt cgaaattaaa aataatgaaa 1797541 tttacatgaa acgctctaaa gcatttgttt ttatattagt cggtcttttg gtgatcagaa 1797601 tcgtgatgaa atcgatcttg agcacatcaa ttgattatgg tgcactgagc ggaatgtttt 1797661 ggattctggc tttcggtatg attgtgcctt ggagaatcgc catgtattta tcatatcgaa 1797721 aacttcataa cgagctgcag tcatctaata ttcaaatgaa ttaaaaaacc tttcctcttg 1797781 tcaggaaagg ttttttattt gagaagggtc tgataaggtt ccaaatcgat ttttttgtcc 1797841 cgcagatgcc tttttaagaa ggtatggtct cttttaggag ttgcgagaat atagcctttg 1797901 atcataagtt gctgatcaat ctttgctacc ttttctttta atgcaagctc accgattttg 1797961 cctgcgattt tagcttttgc tgcatctctg aacagctctg gcacgggcgc agtcaattca 1798021 tctagaaact gtttgttttc atcgttccat aaatgtctgc tgttttcaat atagtaatcc 1798081 tgccaatcaa gctctgatct gccgtcctct tttggtaaac gctttaaaaa ctttcgaaac 1798141 atgaaaaaac cgccgattga taataagact accatcatga ttacccaaaa cagaataaac 1798201 cataaaaacc atccttccag catcaatcat tcccccttat tctaaccata ttgtatacga 1798261 agagagatta gaagaacaca gtaaaaaaag aatagaaaaa agtgatagac gtctagtcaa 1798321 aagagatagt agatcatatt ctattgtata gtgaatctgc tatttggcca tgggagagtc 1798381 actagagggt atttgacgat aaatggacgg aaaaaaagtc actttcataa taggggatga 1798441 aagtgacttt ttatgtttag ctgagaggaa attgaagaga aaaagaagag ccatcttctg 1798501 tttctttatt gacggcgact gtgagtattt gattttcgca ttcgacttga atgtttttgt 1798561 cattaaaata aaaaggaagc atcatttgtt tttcaaaagt ctgtcctgac gatttgacag 1798621 ttaagatgaa ctcgcatcca gaaagggtaa ctgttacttg tgtaggctgt aaaaaagtca 1798681 gatccgcttc tataatatac tgctgacttg tttcatataa atcaataggc aatgtttcgt 1798741 cgtaccaggc gaaggggtct tcaaaaaatt gccgaagcca ttcatccata ctatcgaaat 1798801 cattcgcatc gttgcgtttt gaatggttca tggaagcatt cctccacata tcaaccttgc 1798861 tttacatcat atgcggtgga ttataaatgg gtgaacgcat aaaaaaacag acactaaggt 1798921 ctgcttttct tacatatcat ggcttgagtt gtgcttttgt cttgtatggt ttcggttttt 1798981 tacttttttg cttccgctta gaggctcggg ttggccggga ttgtgtcctt taggggcgtt 1799041 tttatgcata tctttacttg tattcttatt ggtcataaaa tgagaacctc cttaaaagag 1799101 ttcggtgtta ttgattggtt tttctttttt tgttattttg gcgttctgct tcagtcagta 1799161 caagctggtc gttttcaata tagccggcgc ctttgccttg gctttttgcg tcattcattc 1799221 cgttaatgac gtgattcgct tttcttttga ccatcattat cacctcaatc ataatatggc 1799281 ttcttttatt gtgttatatg agagagcgta aacagtaaaa attaccggta catttttctc 1799341 ataagtcgaa cttattgtat ttaataaaaa cattgatatt tacttatgta tgattttgtt 1799401 ttaatatgaa attgtgagaa aattgtgatg gaatgtaatg ttcatctgag aatgatctga 1799461 tctgaagggg gattttggag aatggcaaac gagcaaaaaa ctgcagcaaa agacgttttc 1799521 caagcgagaa aaacgtttac tacaaatggg aaaacatatc attactactc tttaaaagcg 1799581 ttagaagatt caggtatagg aaaggtttcg aagcttcctt attccatcaa agttctttta 1799641 gaatcagtat tgcgtcaagt tgacggcttc gttatcaaaa aagaacacgt ggaaaatttg 1799701 gcaaaatggg gaactgccga attaaaggat atcgacgttc cgttcaaacc gtctcgtgtt 1799761 attttacaag acttcacagg ggttccggca gtagtagatc tggcttcact gcgtaaagca 1799821 atggcagctg tcggcggaga tcctgataaa atcaaccctg aaattcctgt tgatctcgtt 1799881 atcgatcact ctgtacaggt agataaagcg ggtacagaag atgcattagc agtaaatatg 1799941 gacttggaat tcgaaagaaa tgcagagcgc tacaaatttt taagctgggc aaagaaagcg 1800001 tttaacaatt atcaggcagt accgcctgca acaggtattg tgcaccaggt caaccttgag 1800061 ttcttggcaa gtgttgtcca tgccattgaa gaagacggcg agcttgtaac gtatcctgat 1800121 acgcttgtcg gaacagactc acacacaaca atgattaacg gtatcggtgt tctcggctgg 1800181 ggtgtcggtg gaattgaagc tgaagcggga atgcttggac agccttctta cttcccagtt 1800241 ccagaggtaa tcggcgcgaa acttgtcggc aagcttccaa acggaacaac agctactgac 1800301 ttggcgttaa aagtaacaca agtgctgcgt gaaaaaggcg ttgtcggtaa atttgttgaa 1800361 ttcttcggac cgggaattgc tgaactgccg cttgcagatc gcgcaacaat tgcgaatatg 1800421 gctccggaat acggtgctac atgcggattc ttcccagtag atgaagaagc gcttaactac 1800481 ctgcgcctga ctggccgtga tcctgaacat attgatgttg ttgaagcata ctgcagaagc 1800541 aatggcttgt tctacactcc agatgcggaa gaccctcaat ttactgatgt ggttgaaatt 1800601 gacctgtctc aaattgaagc aaacttatcg ggtccaaagc gtcctcagga tttgatcccg 1800661 ctatctgcta tgcaggaaac gtttaaaaag caattagtca gccctgcagg taaccaagga 1800721 ttcggtttaa atgctgagga agaaaataaa gaaattaagt ttaaactcct taacggcgaa 1800781 gaaacagtta tgaaaacggg tgcgatcgcc attgctgcga ttacaagctg tacaaataca 1800841 tcaaacccat acgtgctgat cggcgccgga ctggtagcga aaaaagcggt tgagttaggg 1800901 cttaaggtgc ctaattacgt gaaaacgtca cttgcaccgg gttctaaagt tgttacagga 1800961 tatcttgtga attcaggcct tcttccatac atgaaagagc ttggctttaa cctcgttggg 1801021 tacggctgta caacatgtat cgggaactca ggtccgcttt caccggaaat cgaagaagcg 1801081 gttgcgaaaa atgatcttct gattacgtct gtcctttccg gaaaccgtaa ctttgaagga 1801141 cgtattcacc cgcttgttaa aggcaactat cttgcttcac cgccgcttgt tgtggcatat 1801201 gcgctggctg gaacggtaaa cattaactta aaaaccgatc caatcggtgt gggcaaggat 1801261 ggtcaaaacg tatactttaa tgatatttgg ccgtcaatgg acgaaatcaa tgcacttgtt 1801321 aagcaaactg ttacgccaga gctattccgc aaagagtatg aaacagtatt tgatgacaac 1801381 aagcgctgga acgaaattga aacaacagat gaagctttat ataaatggga taacgattca 1801441 acttacatcc aaaacccacc attctttgaa gagatgtctg ttgagccagg caaggttgag 1801501 ccattaaaag gactgcgtgt tgtcggtaaa ttcggcgatt cagtcacaac tgaccatatt 1801561 tctcctgcgg gggcaatcgg aaaagatacg cctgccggaa agtatttgca agaaaaaggt 1801621 gtttcacctc gtgactttaa ctcctacggc tcccgccgtg gaaaccatga agtcatgatg 1801681 agaggaacat ttgccaacat tcgcatcaaa aaccaaatcg caccgggtac agaaggcgga 1801741 tttacgacgt actggccgac tggtgaagta acatccatct atgatgcatg catgaaatac 1801801 aaagaagata aaaccggtct tgtcgtatta gcaggaaaag actatggtat gggatcttca 1801861 cgtgactggg ctgcaaaagg aacaaacctt ctcggcatca gaacggtcat tgcagagagc 1801921 ttcgaaagaa ttcacagaag caatcttgta ttcatgggtg tgctgccgct tcagtttaaa 1801981 caaggtgaaa atgcggatac actcggctta acgggtaaag aagtcatcga ggtagatgtt 1802041 gatgaaacag ttcgtcctcg tgaccttgtg actgtaagag caatcaatga agacggcaat 1802101 gtaacaactt ttgaagcagt cgtccgcttt gatagtgaag ttgaaattga ttactaccgc 1802161 catggcggca tccttcaaat ggtgcttcgt gaaaaaatga agcagtcctg atgaatcaat 1802221 aggaagagaa ggcatttcgc tttctcttct ttttatgaca caatgtgctg cggaggtggc 1802281 atatgctgaa aaaatggctc gcagggatcc tgcttatcat gctagtcggt tatacgggat 1802341 ggaatttata tcaaacatac agcaaaaaag aagtcggaat tcaagagggg caacaagcac 1802401 ctgatttttc tttgaaaacg ctatcaggag agaaaagctc tttacaggat gcaaaaggca 1802461 aaaaagtgct gctcaatttt tgggcaactt ggtgtaagcc gtgccgtcag gaaatgcctg 1802521 cgatggaaaa gctgcaaaaa gagtacgccg acaaacttgc ggttgttgcg gtaaatttca 1802581 cttcagctga gaaaagtgag aaacaggtcc gagcgtttgc tgatacttat gacttaacgt 1802641 tccccattct gattgataaa aaagggatca atgctgacta taacgtgatg tcatatccaa 1802701 cgacatatat cttagatgaa aaaggtgtta tccaagacat acatgttggc accatgacaa 1802761 aaaaagaaat ggaacaaaaa ctggatcttg attagattca gtttttttta tactcaaata 1802821 tgcttacaag ttttcagaat tggaaaaaat aaaagaatat gcggaggtga gaagcgtgaa 1802881 gaagatgaga aaacgttctt ttcatgagct cgtcatggaa aacaaaaaag agctgatgac 1802941 caatacagag tatttaaatc agcttgagga aaagcttgaa cagcgattta agcaaaaata 1803001 acctttaatt tgtattcatg tttacccctc cttttgagaa acctatctgt tgaggaggga 1803061 taaacatggg aaacaacaag aaaaacggtc agcctcaata tgctccaagc cacttgggta 1803121 caaagcctgt aaaatataaa gccaataaag gggaaaaaat gcatgatact tcaggacagc 1803181 ggccgattat catgcagaca aaaggcgagt agcgaaaatt cgagtttatt tctaggaggt 1803241 acatccgaat gacaaagaac caaaatcaat atcagcagcc taatcctgat gatcgttctg 1803301 acaatgtgga aaaattgcag gatatggttc aaaatacaat tgaaaatata gaagaagcag 1803361 aagcatcaat ggagtttgct tcaggagaag ataaacagcg tatcaaagaa aaaaatgcaa 1803421 ggcgcgaaca gagcattgaa gcgtttcgta atgaaataca ggacgaatct gcagcgagac 1803481 aaaacggata ccgttcttaa aaaaccaggg aaacctggtt tttttctttc tgatttgatt 1803541 atggtaaaat ggggctaaat tgacgttaag ggagcagagt aatcttgcat gtatcaaaaa 1803601 aagaaataga agtgcgttat gcagaaacag atcaaatggg gattgtctat cacgcaaatt 1803661 atcttgtgtg gatggaggtc ggcagaacgg ccttgattaa ggacttaggc tttttatata 1803721 gtgatatgga aaaaaaaggc gttctgtccc cagtcgttga tatcaatatt tcctataaaa 1803781 agccgcttca ttacggagaa accgcggttg tacatacatg gatagaggac tataacggat 1803841 ttaaaaccgt ctatggttac cacatttata atccggccgg tgagctttcc atcaaagcca 1803901 cctcatctca tatttgtgtg gataaagaaa gctttaagcc aattcaattc cgcaaagctt 1803961 ttcctgattg gcacacagca tatgaaaagg ccaaaaaata gggaagtgaa cgggatatgg 1804021 cgtttggtgt gaaacgggag gaacttaacc ggtggaaaca agcagtgaaa agaggagaaa 1804081 tcgcattttt aacacattac tggctggatg accgatttcc agaagcaaag accgtgacaa 1804141 aagccggctg tgcagacatt gataagctgg ttcagtgggg agcggcgtac gggttaaaaa 1804201 aagaatggat ccataagaaa agtgaatttc cccactttga tctgctgggg gaaacacaaa 1804261 aatatatttt ggaacaagaa aacctaaccg atcatcttat acgatttcat ttgtaaaaaa 1804321 agaacgcaca tgaagtgcgt tcttttttat tggtattcaa aaaccggttc atcagcgtct 1804381 tctgaatagc tgacgagaag gtcgtggtta tcaaagtacc ataaatcact ttcttcaata 1804441 aagaaggtaa tgccatcagc ttctgcagtg actccagcct cttgtggggc atctttcgct 1804501 acaccgagag aaaaaccctt ttgaacgttg ctgcagcctc catagcggac gaaaaagcga 1804561 acctggtctc cgctttccaa atcgagttct tctttatacc agttcaatgc gtcttcgtta 1804621 attgtcatat tcataacaga acaccccttt gttcttcatt tgaattttct ctattataaa 1804681 cgtattaggc tattctgtgt caaaagagaa gttttttaag cttataacca ttttacttta 1804741 ggttctgttt tattgataat tcgtttaatg ttcgctcggt gtctgtatat cacaaaaata 1804801 gtgagcaggg taacgacaat caataaatac gtatcatgga caaagaaact atatataaca 1804861 gtatagatcc ctgttaacat cgatgagaga gaaacaaatt tagtcaagta taaaaagatg 1804921 aagaataccg caaccatcgt gataaataac aggggtgcgt aaaatagcaa aacgcctcct 1804981 gatgtcgcca cggctttacc gcctttaaat ttggcgaaga tgggaaacac gtggcctaaa 1805041 accgcaaaga ctcctgcaag aagcgggtga atatcaacat gcatgagaaa aggcaatgca 1805101 gttgccagtg tccctttcaa aatatctccg gctatgacga ccgaaccagc ttttacaccc 1805161 aatgtacgga atgcattggt agcgcctaag ttgccgcttc cgtgctcccg aatatcaatt 1805221 cctttggcaa gcttgcccac aattaagcca gatggaatgc tgcctatcaa gtaggccaaa 1805281 ataatcaata aagcaattaa catctacatt tctccttttt caaattccct tctttttatt 1805341 ttaacatgag atgtcatgat ctgatgataa gtttttttgt aaagtttgct tacaaatcaa 1805401 atcaaacatg catcatattt tgatttctcc tgttttgatc gtgtaaaata agtgaaaaag 1805461 gagtgacaca cgatgcaaaa cccttctaaa gcggaaatta aagagattct tcaaagaagc 1805521 aaacgtatag cggtagtagg gctttcagac cgtccggata gaacgtcaca tatggtttca 1805581 aaagcaatgc aggacgcggg ttatgaaatt atccctgtga accctacaat tgatgaggcg 1805641 ctaggtgtca aagccgtttc atctttaaaa gagatagacg gtccgattga catcgtaaat 1805701 gtattccggc gctcagaaca gcttcctgga gtggcggaag agtttttaga gacagatgcg 1805761 ccagtatttt gggcacagca agggctagtt aatgaggaag cataccagat gctaaaagaa 1805821 aaaggcagaa cggttatcat ggatctgtgc ataaaagtgg cacacgctgt aacaaaatag 1805881 gtgcagaact gcaaaaatcc ttgtaaattc aaggattttt gctttttaat tttaagatat 1805941 tgtttgcgta ttacggtgaa acagatacaa taaagcttga acagcttttt ttgaatacct 1806001 tgtccagctg ggtttcggcc gttcgatttg cgaaggtctg ctgctttata tataataaac 1806061 aaacatacgt tctcatagtg taaaaacagc actagccgat gttttgagaa gaactgattc 1806121 gttagctcta tgttgcgatt gcaaacatat tggttataat gaggagtcca aggcagtact 1806181 ggctcgaggc gaggtttata aaaaatatct tatatacaaa tgatgtgtaa cactgaaaag 1806241 agaaagacaa tgttagtttt tgaaaggggt ttgtacgttt ggctagaaaa cagcaatttg 1806301 attacaacga agatgccata caggtgctcg aaggccttga ggctgtcagg aaaaggccgg 1806361 gtatgtatat tggctctact gacgcgcggg gtttgcacca cttggtttat gaaattgtag 1806421 ataactctgt cgacgaggtg cttgccggcc atggagatca cataatcgtc aaaatacata 1806481 aagacaatag tatttctgta caggatagag gccgcggcat gccgaccgga atgcataagc 1806541 tcggcaaacc aacccctgaa gtgattttaa cggtgcttca tgccggaggg aaattcggcc 1806601 aaggcggcta taagacaagc ggcgggctcc acggagttgg tgcatcagtc gtgaatgctt 1806661 tatctgaatg gctgacggtt accattgagc gggacggttt tgtctatcag cagcgatttg 1806721 aaaatggagg aaaaccggtt acatctctcg aaaagatcgg caaaacaaaa aagacgggaa 1806781 ctcttacaca ctttaagcca gatccaacga tgttcagcac aaccacttat aattttgaaa 1806841 cgctctctga gcgcttaaga gagtctgcgt ttttgttaaa aggactgaaa attgagctga 1806901 ttgatgaacg caatgaccag cgtgaggtct tttattatga aaacggcata gaagcgtttg 1806961 ttgcttactt aaatgaagaa aaagacgtct tgtctgaagt ggtctcgttt gagggtgagc 1807021 atcattctat agaagtggac tttgcgttcc agtttaacga tggttattct gaaaatattt 1807081 tgtcgtttgt caacaatgtc agaacaaaag acggcgggac gcatgagtca ggtgcaaaaa 1807141 ctgcgatgac gcgtgctttt aatgaatatg cgcgaaaagt ggctttgctg aaagaaaagg 1807201 ataagaacct tgaaggcacc gatataaggg aagggctttc agccattatt tctgtccgca 1807261 ttcctgagga gcttcttcaa tttgagggac aaacaaaagg aaagctcggt accagtgaag 1807321 caagatcagc ggtggatgcg attgtttcag agcagcttgc ttacttttta gaggaaaatc 1807381 gggacaccgc aacgcttctt gtcaaaaaag caatcaaggc gagccaggcg cgcgaagcgg 1807441 cacgcaaagc ccgtgaagaa gcaagaagcg gcaaaaaacg aaaaaaatca gaagcgactt 1807501 taagcggaaa gctgacgcct gcgggttcaa gaaacccggc aaaaaatgaa ttgtatctcg 1807561 ttgagggaga ttcagcaggc gggtcagcca agcagggacg agaccgcaga ttccaggcgg 1807621 ttctgccttt acgcggtaaa gtcattaata cagaaaaagc taagcttgct gatatcttta 1807681 aaaatgaaga gatcaatacg atcattcatg cgatcggcgg gggagtcggg gcagatttct 1807741 caatcgatga catcaactac gacaaaatca tcattatgac cgatgccgat actgacggcg 1807801 cccatattca agtgctgctt cttacctttt tctatcgcta tatgaaaccg ctcattgagc 1807861 atggcaaggt gttcattgcg ctgccacctt tatataaggt cagtaaagga agcgggaaaa 1807921 aggaaatcat tgaatatgca tggtctgatg aagagatggg ggatgtcctg aaaaaagtcg 1807981 gcaaaggcta taccattcaa cgatataagg gtcttggaga gatgaacgca gaccagctgt 1808041 gggaaacgac gatgaatccg gagtcccgca cacttgttag ggtcaaaatt gacgatgcgg 1808101 cacgtgtaga gagacgtgtg acgacgttaa tgggagacaa agtagagccg cgcagaaagt 1808161 ggattgagaa aaacgtcgct ttcggcttag atgaagaaag caatatttta gaaaatgaaa 1808221 acttatcggt cgctgaggag gtttaatgat tgtcacagcc agaattattt catgatttac 1808281 cattagaaga ggtgatcggc gaccgttttg gacgctacag taaatatatt attcaagaca 1808341 gggcgctgcc cgatgcgaga gacggattaa agccggtaca gcgcagaatt ctgtatgcaa 1808401 tgcatacaga tggaaacacg tttgataaaa acttcagaaa agcggccaaa acggtcggta 1808461 acgtcatcgg taactatcat ccgcacggtg acagctcggt ttatgaagca atggtgcgga 1808521 tgagccagga ttggaaagtt cgtaatgtgt taatcgaaat gcatggaaac aatggaagca 1808581 tcgacggaga tcccccggca gccatgcgtt atacagaggc acgattatct ccgatagcat 1808641 ctgagcttct tcgggatatt gacaaaaaca cggttgaatt tgtgccgaac ttcgatgata 1808701 caagcaagga gcctgtcgta ctcccggcga tgtttcctaa cctattggtc aacggatcta 1808761 ccgggatttc agcaggatac gcgaccgaca ttccccctca tcatctggga gaagtcattg 1808821 atgctgtcat taagcgtatt caaatgcctt cttgctctgt tgacgaactc atggaagtta 1808881 ttaaagggcc tgattttccg acaggcggta ttattcaggg cgttgacggg ataagaaaag 1808941 cttacgaaac cggaaaagga aaaatcatta tccgcggaaa ggctgaaatt gaaacaatca 1809001 gaggcggacg agaacaaatt gtcattactg aaattccatt tgaagtaaat aaagcaaacc 1809061 ttgtaaaaaa aatggacgag ttccgtattg ataaaaaggt tgaaggcatc tcagaggttc 1809121 gtgatgaaac ggatcgaaca gggctgagag tggtcattga actgaaaaaa gaagctgatg 1809181 ccaaaggcat tttgaatttc ttatataaaa atactgattt gcagatcaca tataacttca 1809241 atatggtggc tatccataac cgccgtccga tgctgatgag cctgccgtct attttggatg 1809301 catatatcgg acaccaaaag gaagttgtca caaaccggtc cgtttacgag cttcaaaaag 1809361 caaaagacag acatcatatc gtagaagggc tcatgaaagc tttgtctatt ttggatgaag 1809421 tgattgcaac aatccgttct tctagcgata aacgtgacgc taaaaacaat ttgatcgcga 1809481 aatatgaatt tacagagcct caggctgaag ccatcgtgtc attgcagcta tatcgtttaa 1809541 ccaataccga tatcacagcg cttaaggaag aggcagaaga gctcggtaaa aaaattgaag 1809601 agctcgaatc tattctgagc aatgataaaa aactgctaaa agtgattaca aacagcttaa 1809661 aagcactgaa aaagaaatat gcagatacga gacgctccgt gattgaagaa aaaattgaag 1809721 aaattaaaat caatctcgaa gtcatggttg catctgagga tgtatatgta accgttacga 1809781 aggatggtta cctaaaacgg acgagccagc gctcatttgc cgcttccaac ggtcaggact 1809841 tcggaatgaa agatacggac aggatgctgc atcagtttga aatgaatacg acagacgtgc 1809901 tgctgctctt tacgaacaaa ggaagctaca tctattgtcc tgttcaccag ctgcctgata 1809961 tcagatggaa ggacatgggc cagcattttt caaatctaat cactattgac cgtgatgaaa 1810021 cgattgtaaa ggctataccg ataaaagaat ttgatccgtc ggcatatctt ctattcttta 1810081 cgaaaaacgg tatggtgaaa aagacagagc tcactcatta taaagcacag cgttattcta 1810141 aggcacttgt agccttaaat ctgaagggtg aagatgaact gattgatgta catgtaacaa 1810201 atggggaaag ccagatcttt atggccactc acttagggta tggtctatgg tttggagaag 1810261 acgaagtgaa tgtagttggc gcgcgtgcgg caggtgtcaa agggattaac ttaaaagagg 1810321 atgactttgt tgtctccggt gagattcttc agcaatctga ttcaattgtc ttgttcacac 1810381 agcggggagc ggttaaacgc atgagtcttt ctgagttcga gaagacatcc cgtgcaaaac 1810441 gcggtgtcgt aatgctaagg gaactgaaaa agaatcctca ccgtgttgta gcactgttcg 1810501 cttgcggtct tgaacagcga ctaatggcag aaacagaaaa aggcgacaga aaagaactgc 1810561 agacaaaaga gttgcggaca aacgacagat acagcaatgg ctctttcttt tttgatgaag 1810621 aggaatcagg caaggttaca gctgtttggc gccttcatac agaacaataa taaaaaaccc 1810681 gctcatacta tatgagcggg tttcgtttgt tttttatcag ctttcatggt tggtgaatag 1810741 atctgttaca gcatgaatga cttcaatccc ctgccataca aataaattca gcgctgtgaa 1810801 agaaaataag cctaaaatca ccattcttaa gataaacaac atgtttaaca gcctcctcat 1810861 attttcgtta cataatcggg tgatgttgaa catgaagttt gccgaaataa gacgattgat 1810921 aaaatttggc cagtataaag ctttttttcc gctgacgtct gcgggagtat cccgtacttt 1810981 tgctttcagc ggtcagcagc agaacagcca ttgcccataa agcggtcagc gtaaatgccc 1811041 ctgtgatgga tttcttctca tcatcagcat tttggccggc tttcatctca tgcatttcct 1811101 gctggtcggc tacggcttta taatgatggc cgatatcaaa ggcgtgggga attgagaaca 1811161 aatgaaaact ggcaatcgcc aagaataaga tggatgcttt caatatcgtt acttttttca 1811221 aatgatctcc ccctccttta atattactga atatttttat aataataccc caatccatcc 1811281 taaaagtaaa cctgatttat taaatttaaa aataaattta actttgttaa gtatatatct 1811341 ttttgcttat ttttgaaaga gaaaacttct tttattagcg tatgtatacc cggtttatgg 1811401 tgtgaataaa aacatatttt aaatgatatg ttgtttagga tttattactt tatttatgtg 1811461 taaatcaaag agaaaggcaa gagaatggga agaaatgatt acattgttaa tagggtactc 1811521 tttttttaaa gccagtttgc aaggaatgtt tttattcgta ggaaaataat agagaagggg 1811581 tcgacagagt aacatctggc tatgacaata ttcttctcga aaaaacttcc taattcgtca 1811641 tattgtgata taataaaact cgttatgtta aaaaatctaa catcaaaatc gaattcgtat 1811701 tgaattgatg aaaacgggag gtaaatatgg agtctttttt caatagtttg attaatattc 1811761 caagtgattt catctggaaa tacctatttt atattttaat agggcttgga ttatttttta 1811821 ccatacgttt tggttttatc caattccgtt attttattga aatgttcaga atagtagggg 1811881 agaagccgga aggaaataaa ggtgtttcat ctatgcaggc attctttatt tcggccgcat 1811941 cccgagtcgg cacagggaat ttgactggtg tagccttagc aattgcgaca ggcggaccag 1812001 gcgctgtatt ttggatgtgg gtagtggctg cagtaggcat ggcttcaagc tttgtcgaaa 1812061 gtacattagc acagctttat aaggtaagag acggggagga tttccgcgga gggccggcct 1812121 actatattca aaagggtctt ggtgccagat ggcttggcat cgtttttgca atcttaatta 1812181 ccgtctcatt cggcttgatt tttaacgctg ttcaaacaaa tacaattgct ggagcattgg 1812241 atggcgcatt ccatgtaaat aaaatagttg tagccatagt tctggcggtt ttaactgcgt 1812301 ttatcatttt cggcggttta aaacgtgttg tcgctgtttc acagctaatt gtgccggtta 1812361 tggcaggcat ttatattctt atcgctttat ttgttgtcat cacgaatatt acggctttcc 1812421 ctggcgttat cgctacaatt gttaaaaatg ctttaggttt tgaacaagtc gtcggcggcg 1812481 gaataggcgg catcatcgtt atcggtgcgc aacgcggact tttttcaaac gaagcaggaa 1812541 tggggagcgc accaaacgcg gctgcgacgg ctcatgtatc ccatccggca aagcaaggct 1812601 ttattcaaac attaggcgta tttttcgata catttatcat atgtacgtcc acagcattta 1812661 ttattttgct gtacagtgta acgccaaaag gcgacggcat ccaagtcaca caggctgctc 1812721 ttaaccatca cattggaggc tgggcgccga ctttcatcgc agtcgcaatg ttcttgtttg 1812781 cattcagttc agttgtcggc aactattatt atggcgagac aaacattgaa tttattaaaa 1812841 caagcaaaac atggctgaac atttaccgta tcgctgttat tgctatggtt gtgtatggat 1812901 ctttatcagg cttccaaatc gtttgggata tggcggacct ctttatgggt atcatggcgc 1812961 tgatcaactt aattgtgatt gcgctgctgt caaacgttgc ttacaaagtg tataaagatt 1813021 acgcgaaaca gcgtaagcaa ggacttgatc ctgtgtttaa agcgaaaaac atcccagggc 1813081 tgaaaaacgc tgaaacatgg gaagatgaga aacaagaagc ataatataaa tataaaacaa 1813141 agctgcattc aatagttgaa tgcagctttt tcattattgg aaataaattt aatttttcga 1813201 ctcgaatgaa aaatgacgtg taaagtccca attcagtcca gttttctttg ttctatatgt 1813261 gtcatgtgtg tcttattcat tggaggtaga gcaaattgac aggcttttaa acctccccaa 1813321 aacaagaaat taggttgata gacaatcatg agaaagattt ttacaatgag ttcgtgctca 1813381 taagaagtgt agagccaaaa tgatgcgaag gaggaaaaga tcagatatga aacggtcaat 1813441 ctctattttt attacgtgtt tattgattac gttattgaca atgggcggca tgatagcttc 1813501 gccggcatca gcagcaggga caaaaacgcc agtagccaag aatggccagc ttagcataaa 1813561 aggtacacag ctcgttaacc gagacggtaa agcggtacag ctgaagggga tcagttcaca 1813621 cggattgcaa tggtatggag aatatgtcaa taaagacagc ttaaaatggc tgagagatga 1813681 ttggggtatc accgttttcc gtgcagcgat gtatacggca gatggcggtt atattgacaa 1813741 cccgtccgtg aaaaataaag taaaagaagc ggttgaagcg gcaaaagagc ttgggatata 1813801 tgtcatcatt gactggcata tcttaaatga cggtaatcca aaccaaaata aagagaaggc 1813861 aaaagaattc ttcaaggaaa tgtcaagcct ttacggaaac acgccaaacg tcatttatga 1813921 aattgcaaac gaaccaaacg gtgatgtgaa ctggaagcgt gatattaaac catatgcgga 1813981 agaagtgatt tcagttatcc gcaaaaatga tccagacaac atcatcattg tcggaaccgg 1814041 tacatggagc caggatgtga atgatgctgc cgatgaccag ctaaaagatg caaacgttat 1814101 gtacgcactt catttttatg ccggcacaca cggccaattt ttacgggata aagcaaacta 1814161 tgcactcagc aaaggagcac ctatttttgt gacagagtgg ggaacaagcg acgcgtctgg 1814221 caatggcggt gtattccttg atcaatcgag ggaatggctg aaatatctcg acagcaagac 1814281 cattagctgg gtgaactgga atctttctga taagcaggaa tcatcctcag ctttaaagcc 1814341 gggggcatct aaaacaggcg gctggcggtt gtcagattta tctgcttcag gaacattcgt 1814401 tagagaaaac attctcggca ccaaagattc gacgaaggac attcctgaaa cgccatcaaa 1814461 agataaaccc acacaggaaa atggtatttc tgtacagtac agagcagggg atgggagtat 1814521 gaacagcaac caaatccgtc cgcagcttca aataaaaaat aacggcaata ccacggttga 1814581 tttaaaagat gtcactgccc gttactggta taaagcgaaa aacaaaggcc aaaactttga 1814641 ctgtgactac gcgcagattg gatgcggcaa tgtgacacac aagtttgtga cgttgcataa 1814701 accaaagcaa ggtgcagata cctatctgga acttggattt aaaaacggaa cgttggcacc 1814761 gggagcaagc acagggaata ttcagctccg tcttcacaat gatgactgga gcaattatgc 1814821 acaaagcggc gattattcct ttttcaaatc aaatacgttt aaaacaacga aaaaaatcac 1814881 attatatgat caaggaaaac tgatttgggg aacagaacca aattagttaa gctttttttt 1814941 ggcggacatc agtaacgatg tccgttttta tcatctaata ggaggtttgc gttgtggatg 1815001 aaatactgaa acagtatatg gtgctgtata aaaaaatgag taatatgata aatggtcccg 1815061 actatccagg taaggaaaaa gacatccagc atcaaaaaga tcagatcgaa gtttacgaaa 1815121 aacagctgca gcaaggattt tctacagatt atgactatga tgtgtttgct gattctgtta 1815181 tcaaatgcgc atatggcgat atgacgctgg aagatttaga agccgtttat tatggattga 1815241 caacaccatt tttttgattt gtcattcagc agtaaaattt caatttctgt ctcactaact 1815301 taagtatact ttgatattga gacagaaatt tatttatttt gtttacttcc tagaatatat 1815361 attatgtaaa ctagaaaaga tgaagaataa agctttgctg tttttatgta catcctttct 1815421 tcttcctgta attcagcaac aaaataaaaa agcgatttcc caatcggaaa atcgccaatt 1815481 cagacactct attatttatg tgtgtctttg tgctcttaac gatttacaac aaatgttgtc 1815541 acgctttgag ctggaagatg agcccaaaaa tgattgcctg atacagtgag attcgttcca 1815601 ggttgtagat tgctgctgct gctcgtgatc catctagata cgtttgaagc agatccattc 1815661 tgcaaaacaa agttttggtt gactcctgtg ttgcttttat tgatggcaac aataacgacc 1815721 ttgttgtcac ctttataggc tgacacgtaa acgttcgcat tagggttttt cgttgcatca 1815781 atccttacat agccgggacg cacaaacttt gagaaatgag ccatattgta gccgcgtttg 1815841 ctgatcgtac catcttcttt cataggtcca tatgatcttc ggatgtacca ccatacataa 1815901 gcttgaaagt ccccctctac catcgcattg tgaatatgct gtgaaacatc caatgcctca 1815961 ggccatcgat ccgccgagtt ggtatcactg tttggatagt atacttccgt catccaaagg 1816021 tccttccccg ctcctttttg tttgaaaaga ggataaggga attggctgac ctgggtgccg 1816081 tacaggtgag ttccgagaat atccatattg gcaagagcct gcggatcgtt caagatcggg 1816141 tccgacaaat tcttcaagta ttgaaatgac tcaggcgcaa tgacgcgggc attgatcgag 1816201 ccggcgtttt ctctcataaa gcgaagtatt tcttgcggcg tccaccacgt ccactcgtga 1816261 gcgtaatcag gctcgttttg gaccgaaatc gcgtaaagat tcacaccatt attcttcatg 1816321 aaggtaacaa aatcgttaag atgctgcgcg tatgctgcgt acttgttgta tttcagccgt 1816381 ttagccgatg tgtcaccatt ccgattaaag gtctcaacca tatcacttgg aggattccaa 1816441 ggagaagcaa aaacgattgc tccgtgtttg accgcactct ttgcagtctc cacctcttta 1816501 taccaattat ttcgattttc atctacatga attcttaaga ttgaaaatcc taactggttc 1816561 tgtccattgc caaaagcagt ttctctttga gctgctgtaa gatccccagc ccaagccgga 1816621 tgattcatcc ctccaaaacc gcgaatcact tgtttctctg cagatacatt aactgttaca 1816681 tcacttgctg ccaaaacttc agtagcgcct ggccctaaca tgactgacag catagtgaaa 1816741 catactaata gtacacaaat tgtttttttt atgcgtggaa tcatttattc ctctccttcg 1816801 tcatgtgtct tttacggtat taaaaaatct gcatggcata tccataatgg cgggctgttc 1816861 cggtgctggc ccgtacttca cccgcctcgt ttttaagcgg tcccattacg agtactatct 1816921 ttgcgtaaac tgccagtaat caaaattaaa caagtttcct gtacctgttc cggtaaatac 1816981 aaagaatact ttgtgcacac cggttgcccc gcttaccgca gtttctattt ccctccacgt 1817041 ttgcgctccg cctgttgaag gcacattcag agttccaaca agcttaccgt ctgcactgtc 1817101 gaggcgcact tctattttcc cgcctaaagt ggatgctaca tttgctttaa atgacctggc 1817161 accgcccgct ccgaagtctg catttcctac agcaatccag tctccatttt gaatgcttgt 1817221 tacatgctga ttatttactg gcccgccggg tgctgtggac ttctctgtca aaatgcgtcc 1817281 attccaagca aacgtttcag cttctacccg gttatatggg tttaaattgg aaatttgtgt 1817341 tacacctgca taatttgccg ctacctcttg aatagatcca tctgcattat gcaccagctt 1817401 attaatatgg ggagagcggt atcctttgcc ggccccgaac agagcggaac tgacagtttg 1817461 cgcatggtac accacatacc actcgttttt aaaattgaaa acagcatgat ggttgtttcc 1817521 gccacctccg aaaaatgcac ccggattttt caggaagtgc cctctatatg taaagggacc 1817581 catgggactt gaactggtca tgtagccgat ctcacccggg ggtttatcgg ccgggtgcgt 1817641 gccgccgaaa ttgatgcaat aggagtaata atatgttccg ttatacttgt gcaatcccga 1817701 atcttcaaac atgaaaggcg catcaattgt agatgcactt ccaacaacac tcgtcatatc 1817761 aggccccaat tttatgactc tagccgtttt aggattggcc cattgtccct gcgttggatt 1817821 tgaaacgcca ggaacgcctc cgccggcata caggtaaccg gttccgtcgt catctacaaa 1817881 tactgccgga tcaaaaagcc atacaacacc agacattcct ggcgtacttg gcgttacgag 1817941 cggttttccg attgggtcgg tccatggacc aatcgggctg tctgcggtga gaaccccgat 1818001 acctccgccg ctgtttgcga aataaaggaa gaatttatcc ttgccattaa tttttttaac 1818061 tgcgattgac ggtgcccatg acgcacctgc ccattttgca attccacggc ctccattagc 1818121 tccattggca cctgctaccg gaatggctcc gtggtctgtc cagttcacca tatccgctga 1818181 agatatgacg aatactctat tcaaattggc aaatgaatta tctttaattg ttccgttgct 1818241 attatattca tagtcatcac ttgacatata gatgtagact cttccgttat aggtcagcgc 1818301 aaccggatcc gctcccaaat gatggtcgat aagcggattt gaattcccta tatgttttgc 1818361 aattgtagta ctagtggcag catacgcaga cttcccagat aagcagctca ataataaaac 1818421 tagaatccat aaacatacgc tacacttttt cctcatcact tcacatcctc ctttttcctt 1818481 aaaatggggg attttctttt ggaatttgat aacaacaggt cacgaagatt gcacgcataa 1818541 agtagccgga agctgtttag caatgttccc agttgttctg aaagctcatc ttcatgtgtc 1818601 tccattctct cttttcttcg aggagatcgc accactcctt caaaattgtt caaaaaaact 1818661 tccccattcc tagcgaccat tgtccagaaa ataaaaagac aggattgttc atggcctccc 1818721 actaatcaca ttgaacggag attacatcat tatccaagat atccctttat ctaacatcct 1818781 acatcattaa aaaaattgtg tatagaaact tttggaggag ttagtgttcg attctacaaa 1818841 ggaactggat acatttattc attgataaga tggggctaac actccgttta tatttgtatg 1818901 ttttcagaca caaaaaacag ccgttcaatg cggctgtttt tttcaagagt ataagactat 1818961 tgagcggtat acccgctttt tcatgttttg ttcatatttt attaattgtt tattcaacac 1819021 tgtccgctat agtaatccat atcaacaaat atgactgcca ctcgcatctt ttatgaaggg 1819081 aggttcgtta cgctgaaaga aaaaataaag acattaggcc gtttttgcac cgtaggcgtc 1819141 ggcaatacgc tgatagattt tggtgtcttc tttcttctta ccgcttgtca tgtctcttat 1819201 ctgccggcgc agatctgctc ctatactgca ggtatcgtca acagctatgt gtggaaccgg 1819261 aattggacgt tttgtgtgaa acgtaaggct gacgggaaag agatcgtgcg ttttctcatg 1819321 attaatattg ccgcgtcagg gatcaccttt ttgctgcttt atttgtttca aaattgcggc 1819381 tgctcgcttt tggtgagtaa gctcgccgcc actatcggcg gaatgatgat gaattttatc 1819441 ggaaaccgaa tctgggtatt tggagattcg ctgaaaaaca tacaggatca ggagtgaaga 1819501 tgaatgagaa aaaaagtgag aaaagcggtt atacccgcag cgggtttagg aacgagattt 1819561 ctgccggcga caaaggcgca gcctaaagaa atgcttccaa tcgtcgacaa accagcaatc 1819621 caatatattg tagaagaggc cgcagagtca ggaattgaag atatactgat tattacaggg 1819681 agaaacaaac gctcgattga agatcatttt gatcggtcgg cggaattgga attcaatctc 1819741 cgggaaaaag gcaagacgga gacacttaag gaaatgcagc agattgccga tttggccaac 1819801 attcattaca tccgccagaa agaaccgctc ggattaggcc atgcggtgct gtgtgcggag 1819861 cattttatcg gagatgagcc ttttgctgtt ctcttaggtg atgatattat ggtgtctgaa 1819921 acaccggctc ttcggcaatt aatggatgta tatgacgttt atggcacaga ggttgtcggt 1819981 gtacagtcag ttctccctga ggatgtcagc aaatatggta ttataaatac atcagggtct 1820041 caagggcatg tatatgaagt gaacgattta gtggaaaagc cttctcctga agaagcacct 1820101 tcggaaatcg cagtaatggg acgttatgtg ctgaattctt cgatcttctc cgttttgaag 1820161 acaattggca gaggcgcggg caacgaaatt cagctgacag atgcgcttcg tgaggtttgc 1820221 cgtaaggagc cgatccatgc ccggctgctg gaaggaaatc gatatgacat tggcgataag 1820281 ctgggctgtt ttaaagcgag caccgaaatc ggcttaatgc gtcccgaaat gagatctcag 1820341 cttttggcct atttagaaga tgtgatcaaa cgggaaacga aagaaatgct gcggtaaaaa 1820401 aattgtaacc atcttgctcg tcaatcagtc atataatagt gaaaaagatt aggacaggtt 1820461 gtgaagaatg tgggcagttt gataagcgaa attttaacat ggctgacgaa catgggatat 1820521 gcgggtattg cgattgggtt aatgattgaa atcattccga gtgagattgt attagcttat 1820581 ggcggctata tggtatcgga gggcacgatt ggatttattg gcgcaattat tgcgggtgtt 1820641 atcgggggca ccattgccca gatctttatt tactggatcg gtcgctatgg cggcaggcca 1820701 tttctggaca aatacgggaa gtatttattg attaaaaagc atcatatcga tatgtcggaa 1820761 aactggtttc agaaatacgg cgccggagtt gtcttctcgg ctcgttttat accggttgtc 1820821 agacatgcca tatccattcc ggcaggtatt gccagaatgc cttttctcaa atttgtggta 1820881 ctgactgtgc ttgctatcat tccatggtct atcctgtttg tttatttagg catacagcta 1820941 ggaagccagt gggatgatgt tgagaatata gcaggcactt atacaacacc gattatgata 1821001 ttggctgttg tcgtgatagc cctttatttt gtgattaaga aacgtacagc catatttaaa 1821061 cgatagctag cggatatgca taggggtgac tgacgctccc ctatgcatat ttttttactt 1821121 gcgatgttga tttgccagct tcagattctc cgctaaaaat gcgacaaaca cttcatcccg 1821181 cacgagcgat gcggcataat ttctcttaat aaaccattct gcctcttcaa acgctgcgaa 1821241 tgtttcgtct tgggtttctc cgttaatttg aatattccat tcgttgtcta aagggaaaag 1821301 aaaaaatctc atttgtgcgc gattttcata taatgatcca ttcgcagatc cctttagatt 1821361 atagatgtta cggaaggcat ccggccgtac aggatcaata cggaaagctt cagctacaaa 1821421 caactcgtat acttcatcgg ttattgaaca gccggacgct tttgcatgcc ctccgccgcc 1821481 atatcggccg gcgatttctg acacatcgat gtaatcatga atggtgcgga gactgactcg 1821541 ttttgacccc atgctcaaaa tcgcaatgta atcgaggtgc gggttatctt tccctagcct 1821601 gttccccagc tctgaatggt acgattcagc gtgaacgatg cctacacagt gttcgtgaac 1821661 aaaggtttgt accatttccc ttttctttct gcggaggtag cgctcgattt tttcgtcttc 1821721 taaatcaagc agtttttctt caaaatcatc gaagaaaaat tcgtcatgcg tggaaaggcg 1821781 ctggatcatt tttgcttcaa attcatcgat tgacagcaaa aagaaaagat cattaagccg 1821841 cttcgcctgt ttttgatcgt accgctccca ctcccatgta tcgtattggc ggacgagctc 1821901 tgtgaattga tctaaggcgt ttgtcggttt catgaagcca ttttcaatga gatagccata 1821961 taaaagcgat gtcgcggatg tgagccttcc atcatcgtat tccacctgga caaatcccca 1822021 ttcatgctca ttcaaatgaa gggctgtttt atgatggtca atgagcttca ctttgccccc 1822081 tgcatgaaca tactcattca atctctcttc gttttcttca ttgacggcga gatcggtgat 1822141 gaataacgcg tcctgtctgt tgctctcctt cgctttttct aaaaagtact gcacctgtgc 1822201 gtttaagccg ttgacagagt tataccggat ctctacgtct tttccgaacg ccaattttgc 1822261 tacgattccg catcctactc cgtccaagtc gttatgtgaa tataaatgat acataatgta 1822321 ggcccctttt tatgataaac tgacaattgc cgctagaggt gcggcagcct ttatttacta 1822381 ttctaaaaaa ccaagcgttt tatgcaatgg taattagttg acataatgtt gttattgtaa 1822441 atatataaag gagcgctttt tttgcgctcc taagttcttg cttttacacc ggataaaccg 1822501 gatgctttcg attggtaaat gtcatttcct ttgtcatgta tgccttgagc cgtttggcca 1822561 gctcatcacg cagcgaattg gctgggataa cagcatcaat gatcatttct gaagccagac 1822621 ggtagatatt gatgtcctct ttgtattcct cccgtttgct gctgataaat gcggctctct 1822681 cttcttctgg cagctcggcg atttttttag cgtagacagc gtttacagcg gcctcagggc 1822741 ccatgacggc gatttgggcg gttgggagcg ctagacagca atccggttca aatgccggcc 1822801 ctgccattgc atacaacccc gccccgtaag cttttcggac aatgacagag agttttggaa 1822861 cagttgcctc cgacatcgca gaaatcattt tcgctccgtg tctgataatc ccagcctgtt 1822921 ctacttttgt gccaatcata aaaccgggga tatcggctaa gaacagcaat gggatatgaa 1822981 aagcgtcaca taaggtaata aacttagccg ctttgtctgc tgaatcgtgg aataagacgc 1823041 ctccttttac cttcggctgg tttgcaacaa tgccgacagg ctgtccgtgg attcgtgcga 1823101 ggcccgtcaa taattccggt gcaaataagg ctttgatctc aaaaaatgag tcttcatcta 1823161 tgacccgctc aatgagctca tgcatatcaa aaggtgcgtt ttgattttgc ggaatgacgt 1823221 cggcaagcgg agtttcgaag tgttttggcg ggcgtttctc atgaatgggc gctttttctt 1823281 gaaaatttgc cggaaagtaa gacaaataag cccgcaccag ctgtatggct tcttcttcag 1823341 tttctgcaag aatatctccg cagccggaga ttgagcaatg catacgggcg ccacccattt 1823401 cttcgagaga cactttttct ccaataacca tttccgccat ccttggcgaa cctaaataca 1823461 tggaggcgtt accgtctacc ataacgacga tatcacagaa ggccggaata taagcgcctc 1823521 ctgccgcaga tggtccgaaa agcagacaga tttgcggaat gcgtcccgat aatttgactt 1823581 gattgtaaaa aattcttcct gcaccgcgtc tccctggaaa gacattgatt tggtcggtaa 1823641 ttcgggcgcc tgccgaatcg actaaataaa tgagcggaca gtttaatttt tcggcgattt 1823701 cttgaattct gatgattttt tcaactgttt ttgctcccca tgaccccgct ttcactgttg 1823761 aatcattcgc catgacgcaa acggtttggc cgccgatttt gccgatagcg gttacaactc 1823821 cgtcagcggg aagcccgtct gacatacatt ccgcaaaaaa agcgtcttct agctcaatgt 1823881 catcgtcaaa gagaagggaa agccgctctc tgacaaagag cttgcctttt tcccgattgc 1823941 tttgatgata cttttccgct ccgccttttc gaatccgttc agcccgttct gttcgttcct 1824001 tttcataatc catcagcatt gcctcccttt tatattccct tgtatacggc ccgtcttttt 1824061 tcttgaaagg cctgaagccc ttctctcctg tcttttgtcg ggatggtttg ttcatacgct 1824121 ttttgttcaa tcgcaaggcc tgtagcaaga tctgtctcca atcctttatt gattgcaaat 1824181 ttagcctgac ggacagcgat cggtccgttg gcagaaatgg ctgcggccag ttcctctgct 1824241 tttggcataa ggtcacaagg agccgtgaca tgctctacaa ggccgatttc ttttgcttcg 1824301 tgtgcggtca cgcgtctgcc tgtataaatg aattcttttg cttttcctct gccaatcagc 1824361 cggggcagcc tttgggtccc tccagcgccc gggataatag ctaaccctgt ttccggaagt 1824421 cccagcacag ctgcttcagt tgcgattcga aggtcgcatg ccaatgccaa ttctagtccg 1824481 ccgcctaatg cgcttccatt tatcgcagct atgaccggct gcggcaaggc atcaagtaaa 1824541 gccgccgttc tttgaatgag agatacactt tccagaacct gatcttcttt cagttttatc 1824601 cgttccttca ggtctgcccc tgcacaaaac gctttttcac cggtgcctgt gaggatgacg 1824661 caacggatgt ttgagttaaa ttcaatttcc tggataatca tttgcaggtt tctaagcatt 1824721 tccgctgaaa gagcatttgc tgcctgaggc ctgtttaagg tgatcaacgc catatgttca 1824781 tttttaacag taaaaagaat agaatctccc attgtatgcg tcctcccttt tatcaagatg 1824841 atttaaacac ctgtaaattt ctgctcggca gcggtttgcc cattttttct tcaatccatt 1824901 tggccgcaga tagcagtttt tctagcttta catttgtttt gatatccatc tgttcaagca 1824961 tgtacacgat atcctcagtt gcggcgtttc ctgatgaacc tggcgcatat gggcatcccc 1825021 caagcccgcc tgccgagccg tcgaacaccg tgatgcccat ttggagtgct gtgaccatgt 1825081 tggccagagc ggttcctctc gtatcatgaa aatgcagggc aatttgatta gccgggaatc 1825141 gtgccaaaag agcttcaagt acagtttcca cttgggcggg attagctgct ccaatcgtat 1825201 ctccaagcga cagttcagaa atcccaaatt caaatagagc ttctgaaagg cgaatgactt 1825261 gttcaatggg gacatctttt tcgtacggac agccgaaaac agtcgagagg taggctcttg 1825321 ttgtgaggtt tgctttttgt gcgtcgttgt ttacttgttt gagtatatgg agggattcag 1825381 aagtggattt attgatgttt tttctgttgt gcgtctcgct ggcggacata aaaacgcaag 1825441 cctcgttaat gcctccttca agtgcattct ccagtcctct ttgattcggg acaagtgccg 1825501 cgtacgttac ccctttttct cggtcgatgc cttttgctac atcgatagca tctcgaagcg 1825561 ccggaatcca tttcgggtga acgaaggatg tgatttcaat atacgacagc cctgtccggg 1825621 aaagctggtt gatccaggtt attttatcct ctgttgcgat ccaaacgggc tcgttttgta 1825681 agccatcacg cgggccgact tctttgattg tcactttttt aggatatggc atggtcttcc 1825741 tccaaattat tgagtggaat tgctcagttc gagcagtacg tctccttcat ttacaaagtc 1825801 gccttccttt tttttgactt cttttacgat tccgcttcta tctgcaacga tcgggatttc 1825861 cattttcatc gattccaaaa tggctacctc ctggcccttt tcgatttggt cgccggcttt 1825921 gacgtggact ttccacaggt ttcctgccat ttgtatgcta accgtcatga caactgcctc 1825981 ctttataggt gctgtttcaa aaagtcagtc gtgacatccc cttctttaaa tgcctttgtt 1826041 gccgcagcct gtatgaggag cggaaggttt gttttgattc cctctacacg atagtcgcga 1826101 agcgctgtct ctagtttttc aattgcttct gttctggttt ggcctttgac aatcatctta 1826161 gcgatcatcg ggtcataaaa aggggtaacg gtgctgtctt ttgctaccgc acattcgtgt 1826221 ctgactcctt tttggtcagg aagtgaaaac gcagtgatcg tacctggtga cgggaagaag 1826281 gtcttgggat cttccgcgta tattcgaacc tctatcgcat gcccgttccg ttggatgtct 1826341 ttttgggaga atgtgagtgt atggcccgca gcaatccgca gctgctgctc aactaagtcc 1826401 aggcctgtta tttcttcagt cacggggtgt tcaacttgca gtctcgtatt catttcgagg 1826461 aaataaaaat tttgtttctg gtcaactata aattcgatgg tgcctgcgtt cgtatagccg 1826521 attgccttcg ctgcttttac cgctgtttga ccgatcttca ttcttagttc atcgtctaca 1826581 aatggagacg gtgcttcttc aatgactttt tggtggcgcc tctgaacaga gcaatcacgt 1826641 tcaaacagat gtactgtatg gccgtgttga tcggccaaaa gctgaacctc gatgtggcgc 1826701 gcatgttcaa taactttttc tatatacata gacccgtcac cgaaaaaatc tgctgcgcgc 1826761 tttttgtttc cctcgtacgc tttttttaat gcttcttcat tttcaacacg ctgcattccg 1826821 atgccgcctc cgcccgctga agctttcagc atgacaggat agccgatttg acttgcggtg 1826881 cggcaggctg cctctatatc tccgagggat tcagaaacgc ccggcaccac agggacacct 1826941 gcagcctcca ttgcttttcg cgcttcaatt ttgctgccca tctttgcgat gatatcaggg 1827001 gaaggtccga taaacacgat gttttcttgc ttgcagcgtt cagcgaaccg gctgttttct 1827061 gataacaatc catatcccgg gtggatcgcg tcggcttttg cttttttcgc cgtctttatg 1827121 attctctcta tatttaaata actttcactg actctcgatt ccccgatcaa atatgcctct 1827181 gtagcggctt ttgtatgggg cgcgtccttg tctgcttctg aataaacagc gaccgtttta 1827241 atgccgagac ggctgcatgt tcggataatt ctcattgcaa tttcaccgcg gttggcgatc 1827301 agtacttttg taaacatgat ttcacctcat tgacttgatg ataagttgaa catttcaatc 1827361 gttttttctc gcagtttata tttttgaatt ttgcctgagg ccgtcatcgg atagtcatcc 1827421 gtaaaaataa cataacgcgg aattttgtgg cgggcgattt tccctttgca ataggcttta 1827481 agctcatcag gtgaaacgct tttaccgtct ttcagtttaa tccaggctgc agcttcctcc 1827541 ccgaatttgg cgtcaggcac accaaccacc tgtacatcta aaacagcggg atgctggtat 1827601 aaaaattctt caatttcccg cggataaatg ttctcgccgc ctctgatgag catatctttt 1827661 aatcttccgg tgatgcggca gtacccgtct tcatccatga cagcaagatc tccggtaaac 1827721 agccatccgt catgattgat tgcttttctg gtcgcatctt tgtctttata atagcctttc 1827781 atgacgtgat agccacgggt gcacagttct ccctgcatgc ctctttgaac ttcttgacat 1827841 gtcccgggtt ctacaatttt cacctcagta tgtggcaggg cacggccggt tgtttcgact 1827901 cttcttatga aggaatcatt tgctctcgtt tgtgtaatga ctggcgaggc ttcggtttgt 1827961 ccataggcga tcgtaatgtc tttcatgccc atcctttcaa tcacagcttt catcacttca 1828021 cttggacagg gagagccggc catgattcct gttcggagcg tcgatagatc atatgcatca 1828081 aaatccggat gatgcagctc ggcgataaac atggtaggca caccatggag cactgtgcat 1828141 ttctcttttt ctaccgtttt aaggacggta acgggatcaa attcttgcac gggtatcatg 1828201 gctgccccga cggatacaca tgccaaaacc ccaaggacgc atccaaagca gtgaaaaaac 1828261 ggaacaggga tgcacatgcg gtcttgagag gttaaagcca tacattcagc gatattagca 1828321 gcgttattga tgacattgaa atgggtcagc atcacgcctt ttggaaaccc tgtcgttcct 1828381 gatgtgtatt gcatattaat cacattgtct ttatccaggc tgttcattct ctcttcaagc 1828441 tcagcatctg tcactgtttt cgccaatatc tctgtatcgt cccaatgata catgccagac 1828501 aatcgtttat tgccaatata gatcagcgtt tttaaaaagg gatagcgttc agatttcagt 1828561 tggccgggct ttgcttcttg cagttctgga attaaactgt tcacgatgtc tggataagaa 1828621 gtgcccctgt atgaatccat gataataagc gccgcggcat ccgattgctt taacaagtaa 1828681 tcaagctcat gtgcttgata attggtattg acggtcacga gcacggctcc gatcttcgca 1828741 gttgcgaact ggacggcaag ccattcagag atattagaag cccatatggc gacgtggtct 1828801 ccttttccaa tccccatccg catgagacct ttagcggttt gacggcacag actgtcaaat 1828861 tgagcgtacg tatagcggat atttcggtct ggatacacaa cagcatctcg atcgggatac 1828921 gcatcagctg tttgttccag cagcctgccg attgtggaat ggatgagttc agccattcat 1828981 tgttcctcct ttcttaatga taggaaagcg tttacatttt tattttaaaa gctgtctggc 1829041 gatcacgaga cgctgaattt cagatgtgcc ttcaccgatt tccattaatt ttgcgtcccg 1829101 cagcatccgt tccaccccat actctttcat atagcctgaa cctccatgga tttgaatggc 1829161 ttgattgcaa gctcttgtcg ccatttcaga tgcgaatagc ttggcgtacg ccgcttcttt 1829221 ggtgaacggg cggttatgat ctttcagcca ggcggctttt aacaccattt gccgtgccag 1829281 atcaatttcc atcgccatgt cagcaagctt aaattgaatc gcttgaaagg aagaaatcgg 1829341 ctgtccaaac tgctttcgct ctttcgcata tgccaatgat gcgtcaaggg ccgcttgggc 1829401 aatgccgact gcaagagcag cgatggagat tcgaccacca tccagcgtat atagaaactg 1829461 tttaaaccct tttgttggat cgccaagtaa gttggccgca ggcactctta catcttcaag 1829521 caagatttcc gctgtattcg aaccgcggac gcccatttta tcgtacgggc tcgtaatcgt 1829581 aagtcctggt gtgtcagttg gcacgattaa tgcggagatg atgttttttc cgtctttgtt 1829641 tttgcctgtt acggcggtta caataactgt gcgtgcgtag cttgcattag tgatccagca 1829701 cttttcgccg ttgattacat actcgtcacc atttgaaatc gcttttgttt gagtgcctcc 1829761 tgcatctgag ccggcatttg gctccgtcag gccgaatgat ccgagtgctg tgcctgaagc 1829821 cagcggcgtc aaatgcgtct gtttttgctc ttctgttccg aagtagtaaa gagggcttgc 1829881 gcctagcgag accgctgcag catagcttaa tccagtactg ccgcaggctt tgccgacttc 1829941 ttcaaccgct aaggcatatg aaatcgtatc accgccagat ccgccgtatt cttctggaaa 1830001 tggaataccc atcagaccga gttcacccat ttttttaaat gtttgcatcg ggaactcgcc 1830061 tgtttgatct acatgttcag cgtgaggagc aatttctttt ttcgcaaaat cttttaccat 1830121 ttcacgcacc atttgttgtt cttttgtcag ctcaaaattc acatcgtttc ctccttcaca 1830181 tctttgtaac atcctattag gcgagttcta taatcattcc ctgacaagaa aagtctgaaa 1830241 attaaaactg aatcattttt tatgtgataa tatcagcggg atgagcaaat acatgcagta 1830301 ggcgcatacc atccatatcg taaacgcaat aacttggccc tttgataaag ccgggaagat 1830361 gaggggaaga ttccaaaggg aaatcgtatc catcaataaa ccgaccgctg atccccatat 1830421 acctagcttg atcaccgcga actgtgattg atcgagtttt tgatagagaa agaacacaag 1830481 gcataaaaca agagcagtgc ccgctcccaa gagaagaaag ttcggcaaaa aggcttcttc 1830541 agccggatca gtcaacacag catctccgaa cagcacaaaa aataatgtgg cacctaacca 1830601 gactagaaat gaaaacgtaa aacacgtcct gtacgtgttt ctcttcgatt ttatttttat 1830661 ttagtactag tttctcagat tccaataatg gtaaatgtcc aaacaccgcc tccatattca 1830721 tgtgaatctc acctttgttt tttaaaaaat tcagcggttt accatcgttt cctgtcccaa 1830781 aatcactttt taaaaaaaga cgacttagaa agccgtcctt ctcatttctt attttgttgt 1830841 tcgtttggaa gctttgcttt cgttatgaag ccggtctgct gaagtgacat aatacgtata 1830901 tttcttgttg ggatctgccg tgttatctaa gaaggtttgc tgctcatgtg tttttctttg 1830961 cgttgccagc aatgttctct gctttttccc ttcggctctg tatatcgcat aataggctgt 1831021 ttctttcgtt ttttgatttg atgggtgatc tttaatctgc agaagattgc cgtttttgtc 1831081 ttcggtgact ttcgtaagct tcggtttttt tggggcggta ttgtcaagcc aaggcatttg 1831141 cggaaccagt gccggcttgc tgtaaagatc ggtgctgaga ctgtctttga tgccaagcgg 1831201 atttttgttg aggtccttga ggctgaaatg catgcttcct ttcaccagtt caagctggcg 1831261 gttcaaagtg atttgccgca catattcctc aggatcggac caaggcggat caaaattgtt 1831321 attgatttta tatgctgcct ggccaatata taagtgaaca ggcctatttt tgacttcatt 1831381 gctccaccaa tcagccagca cgtcgtaagc cgctgcgtta aagccgatac tccaataaat 1831441 ttgcggagca atataatcga tgtcgccttc ttggatccaa tgccttgtgt ctgcatatag 1831501 atcgtcataa tttctgacgc ctgcttttgt attcgatccg gtcgggtcat ctgcggcgtt 1831561 tctccatact ccaaagggac tgatgccgaa tttgacatac ggttttgcag ctttaattgt 1831621 ttggttgatt tgtttgacaa gctggttcac attgtcccgc cgccagtcat cgatattaga 1831681 aaaagcgtct tttccgtatt gttcgtactg tgcttgatca ggaaattcct gtcccgctat 1831741 tttataaggg taaaaataat catccatatg aacagcatcg atatcataat gttttacgac 1831801 ttcttcaatg cctttgacga taaaatctct cgcttctgga atgcctggat gataatacag 1831861 ctggtttcca taggcggcaa cccaatctgg atgttttctt gccgggtgat cctcagacaa 1831921 tttattaaga tctgtatgat tcattgtaat acggtaagga ttaaaccacg cgtgaaattc 1831981 caaatttcgt ttatgggttt cttcaatcat aaatgcaaga ggatcatagc cggggtcctt 1832041 cccttggaca ccggttaagt attccgacca aggcccgtaa gctgacggat aaaaggcatc 1832101 agccgtcggt ttaatctgaa cgataacggc attcattccc attttttgca catcgtccag 1832161 cagtttgata tactcctgtt tttgctcttt cacagataac ccttttttgg acggccaatc 1832221 aatatttaat acggaagcaa tccatacggc tctcagctcc ctgtcagact gcgcattggc 1832281 cataaacgga acggaaatga caaacgttcc gatgatcaag ctgacaagga aacggacaat 1832341 cgacttttgg caaaccttca ttctgtttct tctcccccat tacatcactt tcactattcg 1832401 ctattacggt attcccgggc tataaaaggg tgattaacag aatgtctatc tcactaaata 1832461 aacgaaaaaa gtcctaaagc atgttgtgaa ccgcttttag gactttttat cattcatcat 1832521 ggtttgcaga ctttttaaca catcaataag ttttacgccg acaccgacag ccgtttcaag 1832581 gatcgcttgt gctccggcaa tggctaaaat aaagatcagc ggtattgcaa tacgaggcaa 1832641 aaaaagatag ccaagtccga tcaagatggc acaccaaaca ccggcacacc agtagcaatt 1832701 gagcatgtat ccaaagttag aagccggcac gcttttttca tctacatgcc cgttttgatc 1832761 aacaatcctt ttctttttca taaaaggttt tcggataaat tctgtgattt tgtcaaatac 1832821 aatcaaatgt gtcagcctgt aactggctag aatcagcatg ataaaagtta gaaaagaaag 1832881 acggtccatt gagaagcctc caagaaaaag gatgatgtta tcattcccaa gtgtccctta 1832941 tccattcttg atacaaaaag aaagacggac agagaatggc ctctgtccgc taatccgctt 1833001 tatcgtttgt gcagtattac ttgatttgaa gtgatctttt ctaaaatgtc gaggatgatg 1833061 tcggcattct tttcagcata tgttccttcc agcatgtctt tatgagcgcc aaaacccgtg 1833121 tactcactat agtttccgca ggcgccttcc catttcgtta agcctgtatg cccgctggtt 1833181 tcggggtgga ttccagcttc gatgaaatga atgcttgctt tgatgtggcc ttcattcagc 1833241 aattgtgccc aatattcctg atagtttctt tttttcttca tcaccttttc tctgactgct 1833301 tcaggcagat atgctgcaga ttcgtcatta ccggtatcga taggcaaagg ctgttctttt 1833361 agataagcgt ccacgataat gaagtcgctg acttctaatc ctttgcgctc catagcctgt 1833421 gccacttcaa aagccaggtt tccgcctgca gagtagccta ataaaacgta tgggccctca 1833481 ggctgtatgt ccgtcatgca attaacatat tgttcaatgc gggtgtcttg ttcaataaag 1833541 tgaaacccgt atacggctgc cttctcattc agcaataaag caaggtcttt aaaataaatg 1833601 ccaaatcccg atatcggcgg gaagcagaaa agattttgcg cgccgtgctg gttcagtttg 1833661 atcacatgct gttcatttgc tgctgtcagc tgtttagaat aaagtttttc ggcaagctga 1833721 gcgattgtcg gatgttcgaa caagaaatca atcggtatgt caatgttctg ctgatgtttt 1833781 agtgtatgta tgacttgcag tgctcttagt gaatgtccgc caatagcaaa gaagtcatca 1833841 tcaatactga ttgtgttaac accgaggact tgcttccaaa tgttcgccaa ttcttcttca 1833901 accaagtttc ttggcaatat gatgttctgt cgtttggcag gcttattttc tggaataggc 1833961 agcgcgctgc ggtctatttt tccgtttccg gtaagcggca tccgctccac acgcacccag 1834021 tgctgcggga tcatatagtc tggaagcaca cgcgccaaat cggcgcgaaa atccgtatct 1834081 gtttttttgt gatcaccgac gtaatgagtg tacagctgcg cctctccatc tttttctctc 1834141 aatgtcactg ctgcttcttg aacgccttcc atttctaaca ggcgcgcttc tatttcggca 1834201 ggctcaattc gttttccgcg gattttcatt tgcctgtcaa ttctgctgat gtattctaag 1834261 tttccatcag gcagccagcg cgccaaatca ccagtacggt atattctttc tccaggcaag 1834321 aaaggatgag gagaaaacac agcatttgtc agatctactc tgttcaaata gcctttagcg 1834381 actccatcac cgccaacaca aagctcgccg ggaacgccta ttggcaaaag acgtcctttt 1834441 gtatctaaga tgtaagcggt gctattactg attggttttc caatcggaat cggccccgca 1834501 tagtctctct tcatttcaaa aaaggttgaa aaagtcgtgt tttccgttgg cccgtaaata 1834561 ttatgaagcg cgagatctgg acaggcgtgt ctgacggcat tcatcagggc aggagagagt 1834621 gcttctcctc cgacatataa cgtatggagt ccgcgaaaca tgtcagctcg tacctgtgcc 1834681 agctgattaa aaagagctgt cgttaaaaat agcactgtaa tgtcattttc aagcaaatac 1834741 gctccaaacc gatcaggtgt cagcattgtc gatttatcaa tgatatgaag gcttgcgcca 1834801 tttaaaagtg ccccgaacat ttcaaaggtg acggcgtcaa agctgataga tccagtcata 1834861 ataaaccggt catcaccgga cgcagacgtg taattgctgt ttctgacaag ggacacgaca 1834921 ttgcgattcg tgatcatgac ccctttcggc cggcctgttg atcctgaggt atacatgatg 1834981 tacgcaagat catccgggct ggagctgata ttaataggga tatcgttctc ttccatcaat 1835041 ccctgcgcat ctgaaatgat acatgttcct gagaacgcag cgttttgctc caatcccttt 1835101 tgaacaatca gcatttttgc ctgcgtttcc tcaagcataa agctgactcg ttcaggcgga 1835161 agctccgcat caagcgggag gtatgctccc cctgctttta atacggcaag cacactgatc 1835221 atgaattcgg gagaatgtgc agccaatatt ccggctgtct cgtttttccg aaatcccttt 1835281 tgaattaact ctctggcgag cgcattagag cgtttatcaa gctctttata cgaaatagac 1835341 atattgccat acacaagtgc ggtatggtct ggcgtctttt ctgcttgttc gcgaaataaa 1835401 tcgataattg tatgattctt tggatactcc gtttttgtat tgttgaactg tgtgacaatc 1835461 tgctcttttt ctgttgcatc aagaaaagaa aaatcagcaa ttggcatatg agggtgctgt 1835521 gcagctgtgc taagcgcttg cgtaaattgc ctcttgatac agctgatcca ggcagcatcg 1835581 taaacgaatg cattatagct gaacttgatg acaagctctt cgccaggagc aacgacaaga 1835641 ttaaagttat atcctgattg ctcggatact tgaacttgat cgatttgcag cggtgaatcg 1835701 gtttgatcag cggaatcggc gattttctgc tgtaacggat agttttcaaa gacgataatg 1835761 tgatcaatca gttcctgttt taatgcggtg tttgcctgaa tatcaaataa aggctggcag 1835821 gtaaacggct cagcttccag catttctttc tggcagcgta tgagcagctc gtgaaacgtt 1835881 tcgtcttggt gtgttttaat tcgaatcggt atggtattga taaacaaccc tatcatttgc 1835941 tccacgcctg ggatttctga cggtcttcct gatacaactg cgccaaacac aacgtcgtct 1836001 gtgcggttat attgctgcag catcacaccc cagactgcct gaataagggt agcgagcgtg 1836061 acgccgtgtt gtttggcagt ctctttcagc ttgtctgtca gtggtttatt taatgaaaat 1836121 atcaaatctt cacggtgata actttctttt gtttctttat cagacacacg aggcagaggt 1836181 gatggagcgc tgtagttttt taaataggta tcccagtagg ccgctgcttt ttctttgtct 1836241 cggtttgtca gccatgaaat ataggtgctg tacggacgga cagggtctaa tgaaagcggt 1836301 tttcctgcat gaatcgattg ataaatttgc ataaattcct gcataacgat acctaggcac 1836361 catccgtcca ttaaaatgtg atggtgactc cagatacaga catgctcatc tttagctgtt 1836421 ttgaatagag aaatccgcat cagcatgtct ttttgcagat caaagccttt ttgcttgtcc 1836481 ttctctttaa agcgttcaat atactcattc tggtcgtttg tcggcagatg agaaatgtct 1836541 tcgctgttca aatggaattc acgttctgtc atcacgactt gccgaggtcc cgacaaatgc 1836601 gggacgtgcg gcaaaaacac ggttctgaaa atatcatggc ggtcgataat ggcttgaatg 1836661 ctgcgctgga accagtcata gctgaggctt cctttaatgg tgaagagcga ctgctcaaca 1836721 tacgccccct cctctttacg gaggaaggaa tgaaacagca tcccttcctg catatgactc 1836781 agaggataaa tgttcttgat ttttttaatg gtattcatag tgtctgcacc tttcttcacg 1836841 gattcattag tgaaaactga gcatatcagc gatctcttgc agggcgtcct cggtcagttc 1836901 ttgatcatca aaatcactga tcgtcttttc tgtttcgctt ttgttctggc agtgttcgat 1836961 cagctgtaat aaaaattgac ggcatgtttc gctaagctgt tcgatggttt tgcgctgaaa 1837021 gcgggcattg tcataagtca tattgacagt caattttcct tctgcagcga ttgcgctgat 1837081 atccagcgac tgttcacggt tccatgttgt gctgatatca cctccggcac ccagcggaga 1837141 gaatgagaag gcgtcctcct caggtacttc agctgtgcgg ccgctttcaa attgaccaag 1837201 ataattaaag ctgatttctg gtgcacctgt gaaattgatg tcttttttgc caggcggagt 1837261 caaatatttg atgacaccgt agccgaatcc tttgtcaggt acacgtctca gtgtatcttt 1837321 tgttgttttt agcacatgaa ccatgctttc ttccgaatct ggcaagtctg cgttcagttt 1837381 aatcaataac ggataaatgg cggtaaacca tccaatcgtc cggctcacat ctattccttt 1837441 taatacatcc tctcgcccgt ggccctctaa tgatagtttg aaggcggatt gattggtcca 1837501 atggcgcagc gcaagaatga cagaagcgag cagcatgtcc tgcgtatcag tgttatatgc 1837561 gctgttggcg tcttttaaga gtgctgctgt ctctttatcg tttaaggtaa acgaaattgt 1837621 ggaccgttgt ccctcgtgtg ctctagttcc atcgatttga tcaaaaggca atgcctctgt 1837681 ttgatactct tcggcttcgc gccaatactt gagctgtttc attagctgct ggctttcagc 1837741 gtagtcagag agctttttcg catacgcttt aaacgagctt gttttaggcg gcagtttgat 1837801 atcctccccg ccagcagctt ggcgataccc taaagccaaa tcttcaagca gaacccgcca 1837861 tgagatgccg tcaacgacga ggtgatgagc agataaaaat aagaaatcac cgtcaattgt 1837921 gtggaaaaga ccggcttgca gcagcggacc attcttcaaa tccattttct gctgaatatc 1837981 aagtacatgg cgcttgataa gaggttcata cggtctattt ccatcagtgc cgtccggagc 1838041 tgacaaatca atcatctgaa ggccgtacaa cgcgtcgtcc gaatgactga gcggccgatt 1838101 atattgatcc cactttcctt gttcattctg tgtaaacacc attcgcagcg catcatgatg 1838161 acacgttatt gcttttaacg tttttcgcag tgcgtcttct tgtacagagg tgcttcgatg 1838221 cagcattacg gactgattaa aatggtgttt ttcttttata tcttgagaaa gaaaccattt 1838281 ttgaacaggc gaccattgta cgtctccctc aaccgcagct tggctggaac ttgtatctga 1838341 atcacggata taagctgcca attcttgaat ggtcggatgg ctaaacaaat ctttcactgc 1838401 catttgcttg cctatccggt gaagccgcgc agatacctgt aacgctttga ttgaatctcc 1838461 gccaagttca aagaacgaat cagctgttcc gatcttttct gcccccagta cttctttcca 1838521 tatatctgcc agtatttgtt ccattttgct ggatggcggg aggaatggac gttcaccttc 1838581 gtggttgtat acaggttttg gaagtgctcc gcgatccagc ttgccgtttg gtgacaatgg 1838641 aagtgagtcc agtttttcaa taaacgcagg gtgcataaac accggcagct tgttttgtaa 1838701 ttctgagcgt acagcatttg tgctcaaccc tggttttgtc accacataag cgcttaattc 1838761 ggtttgtcct gacgctgtta catgagcaac tactgcggcg tcttttacac cctttataca 1838821 ccggatgacc gattcaattt ctttcgtttc tacacggtat cctctgattt tgacttgatc 1838881 atcgattctt ccgagatatt cgagtgtacc gtcggccatc catctggcgg cgtctcctgt 1838941 tcggtacatt cgtgcttcgg gtttaaatgg attctgcgtg aatgctctct ctgtcagttc 1839001 tggaagatta acgtaccctc ttgcaagccc tgttcctgct atacaaagct ctcccgcaac 1839061 accgattggc tgaagctgat gattgctatt taaaatcagc acttgagttc cgtcaatcgg 1839121 ctggccgatg cttacgtatg cctgcttttc catatgtctc atgacggtag tcgccacgct 1839181 gttttctgtc ggtccatatt cgttggcgag ttcggtatgc ggacatatag ctaagctgcg 1839241 ggcgatcaat tcgcggtcag ccgcttctcc cgccagtgtg acgactctaa gcgtctttac 1839301 atcttccggc tgcactacgt ccaaaagcgc tcgatataaa acaggcacaa taatcatatg 1839361 tgtaatccgt tgacgagaca gctgatgctt aatggccaga atatccttcg cttcctcttc 1839421 atgaagcaaa acggcttttg cacctgacaa aagcggtgta aacatactag ttataaagcc 1839481 gtcaaatgag aaagaaaaga gctgcagaat ggtatctgtc tcgttgaatg cataagcgtt 1839541 tcgccgccac tgaagagtgt tagcaatccc tttatgctcg accattaccc cttttggacg 1839601 gcccgtcgtt cctgaagtat aaatgatata agccaaatga tgggcagacg acatttgcgg 1839661 cagcggcgat ttgtcgtctt cctctacgct ttctatcgtc aagatctctc cttcaaagtc 1839721 agcaagtact cccagatccg cttcatttat tgtcatcagc agtttcgttc cgctgtcgct 1839781 gaggatatag cgtttccgtt ctttcgggta ttcaggatca atgggaacgt aacagcctcc 1839841 ggctttccac acaccaagta tggatgctat catactgaac gaacgatgca tcatgatgcc 1839901 tactggtgtg tccggcttaa cacctcggct gcgcaatgca cgtgcgattc cattggacca 1839961 ctcgtcaagc tcctgataag tgagtgtttt gtctccgctg acaagtgcag aagcttttgg 1840021 tgttcgtgca gcttgctgct caaacaattg actgattgtt tgaactccgt attgattcgc 1840081 ttgcccggtg ttaaactcat taagcagctg gtgccgctct tcttgggtca ggatgtcgat 1840141 atggttgagt gtcaccttcg ggtttttgcc gatgatgcta agtacatttg ttaaatgcga 1840201 tgcccagcgt tcaatggtgg ttttctcgaa caatgcggtt gaatattcaa aaaggaaatg 1840261 aatgtttccg tcgccctcag atgcctgtag tgtcaaatcg aatttagaaa cgagatgaga 1840321 aacttgtgcc ggcttcattt gcaaatcatg aagatgcaat ggctcgtaat cattattttg 1840381 aacaactaac atcgcatcaa acactgggtt ccggctcata tctcgtgtca attcaagctt 1840441 atcgacaagc tcttcgaacg ggtaattctg gtgctcaaag gcttccaatg ctgtctcacg 1840501 cacttcctgc aaatactgta cgaatggctt cccgccctcc gggcgcgtcc gaagcgccag 1840561 cgtgttcaca aacatgccga gtatcggctc aagatccttg tgcggccggc cggcgattgg 1840621 cgagccgacg atgatatctt cctgtccgct taagcgtgac aagaacgcgg tgtaagccgc 1840681 aaggagcacc atgtacagtg tgcttccgtt ttctcgtgcc agcttgtgaa ggcctgatgc 1840741 aacctctggt tccagcgtaa atgagacctt gtcacccgcg aagcttcgca ccggcgggcg 1840801 ggcatgatca gcggggagat ccagcacagg cagctcgccc tcgagctgct tcagccagta 1840861 cgcctcctgc attttgtacg cgtctcctgt tttgaatcct tcttgccata cggcataatc 1840921 tttatattga atgcgcagcg ccggaagctt ccgattattg tacagctcgc cgaattcttg 1840981 aatcagaatg ttgacggaaa caccgtctga aatgatgtga tgcatatcaa ccagcaatag 1841041 gtgccgctca tctgatacct ttacgatttg ggcacggaac agcggcgctt ggctgagatc 1841101 aaacggtttg ataaatgcgg ctgcggcctc ctgttcggtt cgtgcgccga gaactgtagt 1841161 ctgtaacgta aacggcacct cgtcatggat gcgctgcacc ggatcgcctc cttcgtcctg 1841221 ttcgaaggag gttcgaagcg actcgtggcg cttgatcagc tcttggaaag ctctgtccat 1841281 cctttcaggg ttgagcttcc cttcgagctc taacacagcc ggcatattgt agcctgtccc 1841341 tccgtcctcc agctgctgaa ggacataaat ccgcttttgg gcagaggaaa ccggataggt 1841401 ttcctgtttt tcagcgggct taatcgcttc atatggactg tccgttcctt cacggataac 1841461 ggtagccagt ccttctaccg tcggatgggc aaacacatct tttagcggca cctgtacatc 1841521 gaattctttg gtgatccgtg agacaagcgc cgttgctttt aaggaatgtc ccccgcggtc 1841581 aaaaaagttg tcgtgaatcc cgacagggcc atttttcagc acgtcctccc acagctgaga 1841641 aagcttcatc tcagtcacgt ttctcggcgc tgtgtaggtc tccgcatctg ccgctccgcc 1841701 aggagctggc agggcgtttc ggtcgagctt tccgcttggc gtaaccggcc actgttccat 1841761 ctctatcata taggctggga ccatgtagcc cggcaacagt ctctcaagct gcgctcggac 1841821 ttcgtttctt tggagccctt ctacataagc gcataattcc ggctccccgc tgtctgtccg 1841881 tacggtaacg gccgcctctc ttacaccttc tatacttctt agtgccgctt caatttctcc 1841941 cggctcaatc cggtagccgc ggattttcac ctgatcatcc gtgcgcccga ggaattcaac 1842001 attcccgtca gggagccagc gcgccacatc cccggttttg tacatgcgtt cacccgggta 1842061 aaacgggtct tcaagaaaac gctcctccgt taatgccggc cgattcaaat aacctctggc 1842121 aacacccgct ccggctatgt acagttcgcc gatacatcca acaggcagca tccgctgatt 1842181 ctgattcagg agatataatc tgacatgatg aacaggtttt ccaattggga tccgttcaag 1842241 tttttcatgc ggcggacaat caaagaatgc agcttctacg gttgcttccg ttggcccata 1842301 ggaattggtt attgaaacat ttggaagcaa ctcgtaaaat cgggagacaa gatgggtccc 1842361 cagctgttct cccccagaaa acactcgctt gagtctgttt gtcttaatcg gtacagagcg 1842421 atattttata tgttctaaaa atgcatggag cattgaaggc acaaaatgca tagctgtgat 1842481 cttttgttct tctatggcct tcgcgatcac ttcaggttct ttttcgcctc cctgaggaag 1842541 cagataaaca gaagctccgg cataaggcca ccaaaacagc tcccatattg aagcatcgaa 1842601 tgaatatgat gttttgtgca taatcatatc tgaatgcttt agctgatagc gggactgtag 1842661 ggaattcaaa aaattcaccg ctgatcgatg ttcaatttca acacccttag gcatcccggt 1842721 agagccggat gtatagatga cataggctaa agattgcggg agaacatcca cattcggatt 1842781 ggacaaacga tgtgccagtc cgctatttgt ctgattgaga tagacaatct ctcctgtaaa 1842841 ttccggaaca tgaaggccgg cagactgaag caggagaatg tttgtaccgc tgtcctccag 1842901 cagaaagctg attcgttctt ccggataatc cgggtcgatg ggcagataag cgccgccagc 1842961 tttaagaatg ccataaatgc caagcagcat ttcaggtgaa cgctttccta taatggcaac 1843021 agtcgtttcg ggttttaccc cccgtccgat cagctcccag gcgatacggt tagcctgttc 1843081 gttcaattct ttataggtca tcactccatc ttcgaagata acggccgcct gatcaggcgt 1843141 tttttctgcc tgctgttcga gtgcatagtg gagcgtttga ttcattgaat agcccgtctc 1843201 ctcaaacaga tggcatgatt caatgaaatc tcgctcttct tcttttgtta agattggaat 1843261 attgtccaat tctgtttcag gactggcagc tgtatgttcc acaagcgtgg tgaaaaggct 1843321 ggcccacctt tggatggttt ctttctcaaa caaagctgta ctgtattcaa actgacagaa 1843381 aagctcggaa tcatgctctg taacgtatag ggaaatatca aattttgata ttgggtgctc 1843441 caagtcgttc cactgaagct gtacatcatt catttttagc ttttgctgtt ccatattctg 1843501 aaggactagc gttgtgtcaa acaaaggatt ccggctcatt tcccgctgca caccgagttt 1843561 gtccacaagc tcttcaaacg ggtaatcctg atgctcatac gcttctagtg ccgtctgtct 1843621 gacttctttc agaaattcct caaatgtctt attacccgcc gggcgtgtgc ggagagccaa 1843681 tgtattgacg aacatcccaa gaacagcttc aaggtcggca tggggccgtc cggcgatagg 1843741 tgaaccaatc acgatatcat cctgaccgct taaccgagac aaaaaggctg aatacaaagc 1843801 gagaagcgtc atataaagcg tgcttctgtt tttatgggcg agccgcttta tgcgggccgt 1843861 gatctctttg tccaattgaa aggttacttt tccgcctatg aattgccgtt ctgccggacg 1843921 tcgtttatct gttggaagct ccagtatagg aaggtccccg ctaaactgct gctgccagta 1843981 agtctcctgc ttttggtacg agtctccctt tttaaatttc tgctgccata cggcgtaatc 1844041 tttatattgg atccgcaatg gcttaagctg ccggtttgca taaagatcgg taaattctcg 1844101 gattaggagc tgaacggata cgccatctga aatgatatgg tgcatatcca ccagcaatac 1844161 atgcttctcg tttgacactt ctataaggcc tgctctaaat aatggcgcct ggctgagatc 1844221 aaagggacgg acaaatccct cgatagtggt ctctttactt aacgtaaacg gcacttcggt 1844281 gtggatacgc tgaaccggct cgtcatcagc tccggataca aaggaagttc gaagcggctc 1844341 atgccggctg atcagttctt tacatacagc agacagtttg gcgacatcca gtgcaccttc 1844401 cagttctaag accgcaggca tgttataggc gacaccctca tcaagctgtt gaagcacata 1844461 gattcgtttt tgggccgaag atacaggata tgtatccctt ttttctgctg gttcaattgc 1844521 tgcatacaga ttttgttctg cctctcgaat aattaaagct aatccttcaa cagtcggatg 1844581 agcaaagatg tccttaagtg aaacttgcac atggaattcc tttgcgatcc gtgacataag 1844641 cactgttgct tttaacgagt gaccgccatt gtcaaaaaag ttgtcttgga tgcctatatg 1844701 cccattcttt agcacatctt caaatagttg cgaaagcttt gcctctaaca gatttcgagg 1844761 ggcagtatat gggtttccgc tgattgaagc atctggctcc ggaagtgctg cgcgatctac 1844821 ttttccgttt ggggtaagag gtatgctgtc aacccatatc catttcgccg gaatcatgta 1844881 ttctgggagc tcactagcca tataactgcg taaatctatt gtgttcagct tttgtacact 1844941 gcaatagtaa gcgcataatt catgttcacc gttttgatct tgccagatga gaatggcagc 1845001 ctcactaatg tccggatgat tcattagcgt gacttcgatt tcttgcggct caattcgata 1845061 acctctgatt ttcacttgat tgtctgcccg tccgatatat tcgatgttgc cgtcttcaag 1845121 ccgtctggcc aaatcacctg tccggtacat gatcacatca ggcttgaatg gatcggatga 1845181 aaatttgtcg cttgtcagtt tatcgtgatt gacatatcct ctggcaacac ttgcgccgga 1845241 aatatagagt tcgcctggta cgccgcatgg ctgaagctgt ttttgatgat tcaaaatata 1845301 tagatcagta cagcctatcg gtttaccgat tggcggaagc tcaggaatag ggtctccagg 1845361 atgaatggta tacgtagata ccacatgagt ttctgaaggt ccgtaatgat tgtgcaggtg 1845421 tatgccgcgt ttacgcaaca catcttggaa aaggtctgaa atcattaatt gttccccggc 1845481 tgcgatcagg tgtttgacgc catcaggaaa cgagttcgca agttctcgct cgctgaaaat 1845541 cattttgata aaagcagttg ggagaaacac aatattcgtc tgatgcttgt ttataaatgc 1845601 aaacagctga ggcacatctc tttttatggc ttctggcacg atgtggagtg tgccgccttt 1845661 cagaagcgca gaaaatattt cttgatagca gacgtcgaag gaaggcgtcg caaattgcag 1845721 aacatctgct tcaaagtcaa tgccggagtg agtatattcg aacttcagca agttagccat 1845781 gtttcgatgc tcaaattgaa caccctttgg tttacctgtt gtgcctgatg tataaatcat 1845841 atacagcaga tcgtcagcat tgttgactga ctttatgtta ctgccgtcta ctttgctttc 1845901 gatatcttct ggatgagtga taatgtaatt gtcttctaac gatgagggaa gatgcgcttg 1845961 tgaaacaaca tgcgaacagc cgcaatcatg cagaatataa cggattctgt cagcagggta 1846021 atgcggatca accggaacaa tggcgccgcc tgctttcaag ataccaagaa cacctgtgat 1846081 aaacgccgct gagcgttcca tcataatcgc aacgggttcc tgtctcacaa cgcctttcat 1846141 tcgtaaatgc cgtgccaatc tgttagccgc tttattcagt tctctgtatg ttaatgagca 1846201 ggcttgatca attacagcat gagcatctgg tgtcttttcc gcttgctttt caaacatggc 1846261 atggatggtt tcgtaaactg gtgtttgatc tgtgatttct ccaatcagct gccgcttttc 1846321 agtatctgtc gtgatatcga tttcttcagg tggaagattc ggattattta agatttgtga 1846381 tacagcattc agaagatgct ctttgacaga gagcacaaaa gaccgatcgt gctgctccgc 1846441 atcatagttc attttgatat gaatttcttc ccctggcgcc accataagat aaaagctgta 1846501 gttggtttca tctgcgacag tgaaattatg aatctgaaaa agatcagaag catgttcctg 1846561 tttgttcagc atttgaatct cttgctgcac cggatagttt tcaaatacga gaatatgatc 1846621 aatcagccct tgcttaacag ctgagcggga ttgaatctca tataaagggt ggtagctgta 1846681 cgcttcagcg gcaagacggt ctttttgcat atcttttata agttgaagaa aaggcgtttt 1846741 tgccccctgc acccgaaccg gcatcgtatt aatgaaaaga cctaccatat gttcaatgcc 1846801 ttcgatttct gcgggtcttc ctgaaatgac agaaccgaat acggcgtcat cgttattatt 1846861 atatttttgc agcagaatgc cccaaatggt atgaaaaatc gtactgagtg tcacttcttc 1846921 tctagcagca agctctgaaa gcctgctgct ttcttcctta gagaatgaaa atgtaacgtg 1846981 ttcctgcctg ctttttccct ttgttttttt ctgcttcggg agcacggttt gctgttcgtg 1847041 gccggaaaga taatgatccc aataagaaac cgcctgctct ttgtcttgct ccatcagcca 1847101 tttgatatac tttccgtatg gctggaccgg ctccaatgtt attggggatg catttacata 1847161 agatgcgtaa atatgcagaa actcctttag cacaatgctg aggcaccaac cgtccatcat 1847221 gatatgatga aaggtccaaa tgcaagagta ctggctctct cctgtttgaa tcagagcgat 1847281 gcgcatgagc acatcctttt gcaaatgaaa cccccggtcc cggtcctttt ctttccattg 1847341 ctcgataaac tgtgattgct ccgcctcgtt taaatgagta atgtcttctt ccagtacgat 1847401 gacatttcgt tctctcagaa caacctgctg gggggaggaa acattttggc tgataaaaat 1847461 cgttctgaaa atatcatgtc tttctacaag agcgttgatg ctgttttgaa aaaactgcgg 1847521 gttgactttt ccttctattg taaaagaagc ttgctcaaca tacgcctgtg aatctttttg 1847581 caggagggaa tggaaaagca tcccttcctg catgtaagac agcggataaa tatcctgaat 1847641 tgaattcgct tttgtcatgt tcatgtctcc tgtcacgatt ttctacaatt cttccaccaa 1847701 gctggatatg ctgtccaagt cctctgccgt taatgattga ctgctgaaat cgctcagtgt 1847761 cttttctgct ttctgttgac cggcgcagtg tttcataatg tccagcaaaa agtgttcaat 1847821 cctgttaata agctgttcca ttgtgtttct gtgaaagcgg gctggcggat aactaagatt 1847881 gaaatggagc tttttgtctg ctgccattgc actcatctcg atgatttgct cgcgcttcca 1847941 tgtatgagtg atatcctttc cgctaccaag gcttgatggg cggaaggtgt cctgtctttc 1848001 gatgtcgttg aactggccca aatagttaaa gctgatttca ggtgtttttg aaaacgtaat 1848061 gcttttattt tcagggtgtg taaggtattt cagcataccg taacctaccc ctttgtttgg 1848121 tatccggccc agtgtatctt taacggtttt tactgaggtt ccgagctcat ccctatgatt 1848181 ttcaaagctt atgagggccg ggtacatgga tgtaaaccag ccgaccgtcc tgcttatatc 1848241 taactctggc agaatgtgtt ctctcccgtg tccttccata gcgatacgga gcttgcttcc 1848301 tcctgtccat tcacaaatcg ccaaggatgc tgcggttaac agaatatctt gtgtatctgt 1848361 gccataggcg tgattgacgt tttgcagcaa gacggcggtg tctgcttcag tcagtgaaaa 1848421 gcttaatgag tcccttttgc tgaagtcgat gttcacatga tgcggtattt catagggcag 1848481 ttctgcggct tgctgttctt ctacacttcg ccaatacgcc tcttcgcgaa tcagcttact 1848541 gctttgggca tattcctgta tgcgtcttgc gtattcctgg taggaatccg ttttaggcgg 1848601 aagctggatc gtctggcctg cagcagcttg ttgatatccg gctgacaaat cctccagcaa 1848661 aatccgccat gagacaccat caacgacaag gtgatggatc gcaaggaaca agtaatctcc 1848721 ggtcagtgtt ttaaacaaag cggcgtgcaa caatggtcct tcctgcaaat tgatgctttg 1848781 ctgaagatcg gcaacttctt gtttgatttt cgtctcccag ccgctttctg actgtgaaag 1848841 atcagagatt cttaagctgt atagctgtga ctcatgaatg ccttggttga tttgaatcca 1848901 tcgcctgtca tcgttgcgat aaaccatccg aagcgcatca tgatgctccg ccagtttttt 1848961 caaggctggt ctaagggcgt tttcagacaa acgtccagaa tggaatagca tgacagactg 1849021 attgaaatgg tgtctttctt caatatcttg tgaaaaaaac cattgctgaa caggcgtcca 1849081 aggaacgtca ccctgaatgg gtccttgctc tatgattctc tctgacttac ggataaatgg 1849141 tgataagtcc tttatctttg gatgacggaa taaatcactt acctgcaagc ttagtccata 1849201 gcgcccaagg cgtgcagaaa cttgaagggc tttgattgaa tctccgccca attcaaaaaa 1849261 cgaatcctct attccgatcc tctggatgcc tagaacctcc tgccagatca atgccagctg 1849321 ctcttcaagt tcgttgcgtg gcgggatgta tgtttgttta gatgcgacat ctggttcagg 1849381 cagtgctttc cggttcaatt tgccgtttga tgtgagcgga agagtctcca tttcaatgat 1849441 atacgccggg atcatatagt ttggcagcga acgcgcgaga agagaacgca cttgttcagc 1849501 attcgtgcct gcttttacgc tgatatagcc aaacagctct ttgctcccgg tctgggctgt 1849561 acgtgctaac actgcggctt ctttgacccc gtctatttga cgaagtgctg tttcgatttc 1849621 acccagctcc acccgatagc ctctgacttt tacttgatca tcaatacggc caacgtactc 1849681 aattgtgcca tcggaaagcc agcgcgccag atcacctgtg cgatacagtc gatcgccagg 1849741 tgcaaatgga tgtgggacaa atttctcttt cgttaaatca ggacggccca aatatcctct 1849801 ggcgacgcca tctccgccga cacaaagttc accgacagct ccgaccggct gcagcactcc 1849861 ccattgattt aagataaaag cggtggaatt accaaccggc cgcccgatcg gaatggaaag 1849921 ttcatatgtt ttttgaatgt gaaggcatgt cgaaaaagtt gtattttcgg tagggccata 1849981 tccattccat atagatactt cagggcagac atttctgatt cgattgacgt ggctcggcga 1850041 caaagcttct ccgccaataa tcaaatgttt cagctgtgaa aatgtttgtt cattttgctc 1850101 tgtcaaatga ttgaatagag aagatgtcag ccaaatcgtt gtgattcctt gatgttctat 1850161 gtacctctta agctgatggg aatcgagaaa tgtttgttga tcggacagat gcaaagcggc 1850221 accatttagc agcggtccga aaatttcaaa tgacccaacg tcgaaaccga ttgatgatgt 1850281 catcagaagg cggtcttcag gtgtaaatgt aatataattg ctgtttttaa caagacgaat 1850341 tacacttcgc tgctcaatca tgacaccctt tggtttaccg gttgatccag aggtataaat 1850401 gatatatgca agtgaatggg gccctgctga agattcaacg ttcttcgcct ctccttgctt 1850461 ttgaatatct tcgattatga tttgttcaca ttcaatgcct aatagccgtt tttctgtttt 1850521 ttcagattga aggagtaatg ctgccctgct gtcagacagc atataagcta tgcgttcaac 1850581 aggcagatta gaatcgatag gcagataggc tcccccggct tttagaatgc ccagcattcc 1850641 tgcaatgagt tctggtgttc tgcctgtcaa caaggctaca acactatcag gccctacgcc 1850701 ctttatctgt agaactgagg caatttgatt tgcccagctg ttcaggtcct cgtaagtgaa 1850761 tacttgggtg tcgctgacaa ttgctacagc attaggtgtt tgttctgcct gcatttcaaa 1850821 gagtctgctg atggtttcat ttcttggata atctattttt gtacgattga gctcgtggat 1850881 aaggtaatgg gcctcatcct cattcaggat atttattgtt ccgagagcgg ctttgttgtc 1850941 tttgatgatg gagagtaaca tattgttgaa gtattgaagc cacttttcta tcgttttttt 1851001 cttatataag tcagtactaa actccatttg gaacgtcagc aaaccgcggg gctgttcctg 1851061 ggcatatagg gttaaatcaa atttggacgt ttgatgccca ttgtttgctg caggtttgag 1851121 acaaagttca tccagctcca acgattcctg atccatattt tgaagaacaa acattacgtc 1851181 aaacagcgga tttctgctca tatctcgtgt caattcaagc ttatcaacaa gctcttcgaa 1851241 cgggtaatct tggtgctcaa aggcttccat tgctgtctcg cgcacttcct gcaagtactg 1851301 tacaaacggc ttcccgccct ccgggcgcgt ccgaagcgcc agcgtgttca caaacatgcc 1851361 gagtatcggc tcaagatcct tgtgcggccg gccggcaatt ggcgagccga cgatgatatc 1851421 ttcctgtccg cttaagcgtg acaagaacgc ggtgtaagct gcaaggagca ccatgtacag 1851481 tgtgcttccg ttttctcgtg ccagcttgta aaggcctgat gtaacctctt gatccagcgt 1851541 aaatgagacc ttgtcacccg cgaagcttcg catcggcggg cgggcatgat cagccggaag 1851601 atccagcaca ggcagctcgc cctcgagctg cttcagccag tacgccccct gcgttttgta 1851661 cgcgtctcct gttttgaatc cttcttgcca tacggcataa tctttatatt gaatgcgcag 1851721 tgccggaagc ttccgattat tgtacagttc gccgaattcc cgaatcagaa tgttgacgga 1851781 aacaccgtct gaaatgatgt gatgcatatc aaccagcaac aggtgccgct catctgatac 1851841 ctttacgatt tgggcacgga acagcggcgc ttggctgaga tcaaacggtt tgataaatgc 1851901 ggctgcggcc tcctcttcgg ttcgtgcgcc gagaactgta gtctgtaacg taaacggcac 1851961 ctcgtcatgg atgcgctgca ccgggtcgcc tcctgcgtcc tgttcgaagg cggtccgaag 1852021 cgactcgtgg cgcttgatca gctctttgaa agctctgtcc atcctttcaa ggttgagctt 1852081 cccttcgagc tctaacacag ccggcatatt gtagcctgtc cctccgtcct ccagctgctg 1852141 aaggacataa atccgctttt gggcagagga aaccggatag gtttcctgtt tttcagcggg 1852201 cttaatcgct tcatatggac tgtccgttcc ttcacggata acggtagcca gtccttctac 1852261 cgtcggatgg gcaaacacat cttttagcgg cacctgtaca tcgaattctt tggcgatccg 1852321 tgagacaagc gccgttgctt ttaaggaatg tcccccgcgg tcaaaaaagt tgtcgtgaat 1852381 cccgacaggg ccatttttca gcacgtcctc ccacagctga gaaagcttca tctcagtcac 1852441 gtttctcggc gccgtgtagg tctccgcatc tgccgctccg ccaggagctg gcagggcgtt 1852501 tcggtcgagc tttccgcttg gtgtaaccgg ccactgttcc atttctatca tataggctgg 1852561 gaccatgtag cccggcaaca gtctctgaag ctgtgcacgc acttcgtttc tttggagccc 1852621 ttctacataa gcgcataatt ccggctcgcc gctgtctgtc cgtacggtaa cggccgcctc 1852681 ccttacgcct tctatgcttc ttagtgccgc ttcaatctct cccggctcaa tccggtagcc 1852741 gcggattttc acctgatcat ccgtgcgccc gaggaattca acattcccgt cagggagcca 1852801 gcgcgccaca tccccggttt tgtacatgcg ttcccccagg taaaacgggt cttcaagaaa 1852861 acgctcctcc gttaatgccg gccgattcaa ataacctctg gcaacacccg ctccggcaat 1852921 gtatagttcg ccggcgacac cggaaggctg tacggctaaa tgcggatcta aaacatacaa 1852981 acgcgcacca ggtacgggct tcccaatcgg aatccgcaaa cggtctctgt cccgttctgg 1853041 atctaacacg taaaatgccg cgtctaccgt ggcttctgtc ggcccgtagc catggattaa 1853101 tgatacctgc ggcaatacag aagcaaaacg ggctgccgta cgcggcgcaa gcggttcacc 1853161 tccggcgaat acacgcttta ggcttgtcct gtcactcagc ctttcgattt ccgcttgatc 1853221 gagaaagctg ttcagcatag ccggaataaa atgagccgtt gtcacgtttt cctgatgaat 1853281 ggcttgtacg atcaatgcgg agtctttttc ccagccgggc ggaagcagat acgccgaagc 1853341 accggaaaga gcccaccaaa acagctgcca cacagacgca tcaaaggaaa aagaggtttt 1853401 caccatgaca atgtcatctt ccgaaagccg aaactggtgc tgcatgccgg tcagaaagga 1853461 aacagcctgg cggtgctcaa cggccactcc tttcggctgc ccggtagagc ccgatgtata 1853521 gatgacatag gcgagagatc cgtcgctaac agaagcagac acatgacgtt ttacttcttc 1853581 acactcaaga gatgtcatgt ccacttcaag cgtttcgcca gaaaagtttg gtgcggagca 1853641 tcccggctgt gtcagcaaga gcgatgcccc gctgtctttc agcatgtagc tcagccgctc 1853701 ctttggatac gcaggatcaa gcggcaaata cgcccctccg gccttcaata cagcaaggac 1853761 agcgatcagc atgtcaggtg agcgttcaga caggacaccg acgatacttt cgtttgtgac 1853821 gccgcgtgcc gcaaggtgcg cagccagccg gctggcgtac atatcaagct cagcgtatgt 1853881 cagcgaaccg cctgaaaagc gaatggccag ccgctccggt gtgactgccg cctgtcgttc 1853941 aaacagccca tgcagggttg gggcttcagg tgaaacagat actgtcctgt tattttgaga 1854001 aacgattttc cgtgttttgt cctcatctag caacgtcatc tttgacacag gaagagatgg 1854061 atcagagatg acgtcagaga ccatgtgcag caaataatct tttatttcgg acatcatgct 1854121 tggttgataa gcgctggtct gaaaatgaat ccgaacgtac aaggtacggc ctgggatcac 1854181 tttgacactg caactataat tggtcacctc ttccatctca aaatctttga cggagaaatc 1854241 aaatgacccc gcttgattca gctcttcgat ctcttgctgg gtaggtgtat tttcaaagac 1854301 gataatatga tcgatcaact cttgctttag agcactctgc gcctgaatat catacaaggg 1854361 aaagtaacta taggcttctg cctcattcat gtccttttgc attctcctga ctaggtcaga 1854421 aaaagacaga gaatcacttt gggctcgaat aggaatggta ttgataaaaa gcccgaccat 1854481 gttttccaca tcttttagct cagaaggtct gcctgatata actgaaccga acacagcatc 1854541 gctgctgcga ttgacctttt gaagcataat cccccataaa gcttggaaaa cagtgtttag 1854601 tgtcgcacca gaagctgctg cgattttctg taattcggcg gtttcttttt cgggaatggc 1854661 aaacgtgatc tgctgtagtg tcccattcgg aatttgatct gttcttttcg gcaggggtgt 1854721 agatttttcg aaatgctgaa gcctcttttt ccagtactca gctgcttctt cacgatcttg 1854781 ctgcatcagc catttaatat acgtcccgta cggctgtacg ggaggcaaat caggaagctg 1854841 gcctttaccc agcgcttgat aaatatggag aaagtcttta atgacgatgc ctaaacacca 1854901 gccatccatt aaaatatgat ggtggctcca gatacagaca taatgatcag gcgcccattt 1854961 taaaatagat attctcatca gtacatccgt ttggagatca aagcctttgg atttgtcctg 1855021 ctctttgaat gcctcggtac aatgttcttt atccctttca ttgagatggg aaatatcttc 1855081 aatatgaata gggcaatgac gttgcttgag cacgacttga cgaggtttgg ctacattttt 1855141 atagatgaat gctgttcgaa agatatcgta cctgtcaaaa acagcatcca tacttttttg 1855201 gaaacgctcc aagtcaagct gtccatggat cgtaaaagaa gcctgttcaa aataagctct 1855261 cgactgttca tcatacagtg agtgaaaaag catcccttcc tgcataaatg acaaagggta 1855321 tatatcctgt atttcaggtt gctgcggcat cagtgaatct cctctcctat agtttgttga 1855381 cggctcccat gatctcactc aattcatcaa gcgttaagtc ttcatcagtg aaatcagatg 1855441 cgctccactc ttggttttct ttgccggtac aatgctcaat gatgttttcc agagtctgtt 1855501 taaaatgcct ggaaaatgtt tggattgttt tttcctcaaa ttgaaacctg ttatagatga 1855561 tgtgcatgtt caggcacccc gaagaaacgg cgccgctgat atccagtgca taaggacgct 1855621 cccagttcgg gctgatctca tttcctggct tgatgtcaga cacctcaaag gcatttgatt 1855681 gaatatcctg atcaaactgg cctaaataat taaagctgat ttctgggctg tttttctgag 1855741 agccccatct tttgctgata tatttcagca cgccgtagcc cgcgccttta tgcggtatac 1855801 ggtgcagcat atcttttgtc tgtttaataa ggtggcccag ccgctcttct ttgtccttat 1855861 gatcggaatc tctcatatca agccacacag gataaatgga ggtgaaccag ccaacagttc 1855921 tgctaatatc gatgtcctca agatatgatt cccttccatg gccctccatg ctgattttaa 1855981 attggttatt tcccgtccat ttctgcaaag caagacctaa agctgtcaga aggatatcat 1856041 tcatctccgt gctgtaagct ttatgtgcag ccgttaatag taattctgtg tgatggcgag 1856101 atagctcaaa atcaatcact tctgtatctt tgaatgtgtt agatgctgcg tcattgtctt 1856161 ttggaatagg ctggatgtga cggttctcgc actcatccca gtacgctgct tcgcgctgca 1856221 cctggcggct tatagagtag tcagctattc tttgtgaata cgttaaatat gaatctgttt 1856281 tttgcggcag tttaatagat tctcctgaga ctgcctgttt gtaagctgtt gaaaaatcct 1856341 caaacaaaat gcgccaagaa accgcatcaa caactaagtg atgaatcgtt agaaataaat 1856401 ggtcaccatt ctcggttcta aacaatccag cgtgaagtaa ggggccggtt tccaaacgaa 1856461 tatgttcttg catccggctg gctgcttcct caatcgtgtt ccgggcttct gttaggctat 1856521 cctttacatc aaacagttca agtgcatata gctcctcatc tgaaagatct atccctctgt 1856581 ttatctgcac ttgcctgcca tcttcatgcc ggcatacgat tctcagtgca tcatgatgag 1856641 tcacaaggct ttttagtact tttctaagcg cagcctcatc aaatcgttca gcccggtaga 1856701 tcataacgga ttggttaaaa tgatggcttt ccagagattg cgagaaaaac cactgctgga 1856761 taggtgtcca agtaatctcg ccttcgaccg ggccttggtc aatggcgcgt acgtcttttc 1856821 gaacccgggc ggacagttca ccaagagtct gatgttcaaa catctcacgt actgtcgttt 1856881 caaatccgcg ctgcttcagt ctggcacaaa cctgcagcgc tttaatagag tctccgccaa 1856941 gcttaaagaa attggcgctt acacccagct catctacatt aagaagctct tcccaaattt 1857001 cagccatcac cgtttcaatc tcatttctag gactgatatc atcagctgta taagcttgtt 1857061 tttcaggctc tggcagggct ttctgatcga gctttccatt aacagtcacc gggatgctgt 1857121 caatttgtat catacgggca ggcagcataa agtcaggcaa ggcgtttttt aggtaagttc 1857181 ggatgtctga tatattcgca gcctgttgat cttttatcac catatatgca tatatagctg 1857241 tttgcccttg ctcgtctgct ctggtaatga cagccgcctc tttaatcatt ggatactgaa 1857301 gaagtgccgc ttggatttcg cctaactcaa tacggtgccc tctgactttc acctgctcat 1857361 caatgcggcc taagtattcc agctcgccat ttgacaggcg cttagcaaga tctcctgttc 1857421 ggtataatct gtctcccgga agataaggat tggatacaaa acggtcagcg gtcagctcat 1857481 ctctgttgag atatccccgt gccacacctt cgccgcctat atacagctcc cctggaactc 1857541 cggtcggctg caggttcata tgggcatcca tcacatgagc ctgcagagta gaaagaggcc 1857601 ggccgatatt gcttttattt tttgcaatgt ctgctgcgga caattttttg aatgttacat 1857661 ggaccgttgt ttctgtaata ccgtacatat taatcaaatc agtatgagga tatttttcat 1857721 tccagctttg aagcaatccg ggctgtaagg cttcgccgcc aaaaatcaca tagcggatgt 1857781 ttaaatgatc tgtatgattt tggtcttcaa gcatcaagcc gtaaaaagca gtcggggtct 1857841 gattgagtac agtgacgcgc tcttttttta acaataatcg gaatgcttgg gggtcacggg 1857901 ctgtttcttt agagaccacg actaatgtac ttccgttcaa taacgcaccg aacatctccc 1857961 atacagagaa atcaaagcaa taagaatgaa ataacgtcca gacgtcttca tggttaaatt 1858021 caaaaggcag gttttgatgc ttcaagagac tgatcacatt gcggtgctcg acaatgactc 1858081 cctttggctg accagtcgtt ccagatgtgt atatcacgta tgcgggctga tccgttacta 1858141 tttcttcaat gtttacatca gccggaattg agttgttttc acattcatcg atatacaaaa 1858201 tatgcccggt gtagtctgca ggtttgttta gaccgcgctc tgtcagcagc agttttgctc 1858261 cgctgtcatt gagcataaag ctaatacgct ccttgggata ttcaggatca atcggcaaat 1858321 aggccccgcc agcttttaaa atcgataaaa cgccaatgat catatcaggt gaccgatcga 1858381 gcatcagacc gacgatatcg ccagttctga ccccttgttt gatcagcata gcagctgccc 1858441 gctcggcttt ttcattcagg tctcgatacg taagctgaga atggccgcac accactgcga 1858501 tatgctccgg atactgagct acttgctttt caaataagct tactatgttt tcatttctcg 1858561 gataagctgc atactgcccc attttttcaa ggagtaacct acgctctgca gcaggaagca 1858621 attgcatgtt cgaaattctc atctcagtat ccgccgttac cccttttacc aattcaataa 1858681 aataggatgc ccactgcgta atggtttctt cttcaaaaag agcagtgctg tattcaaaac 1858741 ggcagcgtat tccactcaga tgctcctcag catgtaatgt taaatcgaat ttagatatat 1858801 catgtttagg agtgacagac gaaatcgaca gaccaggcac ttcgaaccgg aaatcttcac 1858861 tgctttgaag cacaagcatc gcatcgaaca gcgggttgcg atttacctct cgatttgtat 1858921 cgagcttatc tgccagctcc tcaaaaggat aatcctgatg ctcgtaagcg gtcagagcca 1858981 ggtggcgaat gtcatgcaaa taggagctga acgttttgtg gccctcgggc ttgctgcgca 1859041 tcgccaatgt attgacgaac attccgatga cgcgctccag atcagcgtgc ggtcttccgg 1859101 cagcaggcga accgacaaca atatcctctt gcccgcttag cttagataac aaaatagaat 1859161 agacagccag aagaatcata tacaatgttg ttcccgtttc agccattaaa cggtgcagtt 1859221 catcagccat gtctttatca atgttgactt caattgttcc acccctgaaa tcagggagac 1859281 gcggccttgt tttatcaagc ggtaattcta gtgtaggaag actcccgcca agctgaccga 1859341 gccagtaggc ctcctgtttt ttgtatagct ctttcgggtg cttctcttgc tgccaaacag 1859401 caaaatcctt ataatgcagg tttaaagctg gcaactcttt tccgcaatat aagtcagtaa 1859461 attcttggac aagagtgctc atcgagacac cgtcggcaat aatatggtgc atatcgagca 1859521 gcaaaaagcc gcgattattg cccattgtaa tgacacatgc tctaaaaagc ggaccggatg 1859581 atagataaaa cggtttgata aaggtctcga ttgcagactc aagcatttgt tctgattcca 1859641 tttcaagctc ttttagatca aaagccatct ctggataaat gatctgcaca ggctcgtctc 1859701 tgtcaagcac aaaaacagtc cgtaatgctt catgccgatt cacaagttct gtgagaacgc 1859761 ttctcaaccg ctggcgattc agatttccgc gtaattcaag tacagctggc atgttgtagc 1859821 ctgtgctgtc atctgccagc tgatgaagag catataatcg tttttgcgag aaagacagcg 1859881 gatagacatc tctttgatcc gcaggttcaa tctgtgtaaa agcgtgttct tttaagctca 1859941 tcaatttgac cgccatgctt tcaaccgtcg gataagaaaa cacctcactg agcggcagct 1860001 cgacattaag ctttttatgt attcttgata ccagtgcggc cgcttttaag gactgtccgc 1860061 ctaactgaaa gaaatcatca cgaatgccga tgtgctgttt attcagcaca tcttcccaaa 1860121 tatgtgcgag atcagcttcg attaaggttc ggggcgccat atatgtgaca ctcgtattgt 1860181 tttctggttc aggaagcgca aacctgtcaa gcttgccgct ggatgttaat ggcatctggc 1860241 tgatgttgat aatacttgct gggatcatat aggacggcaa tgtcccggca agatgctgat 1860301 acaaatctgg gaggctgttt cccttttccg gaacgatata agcaacgagc tccttttcct 1860361 cagcagaaac atcacgggcc agtaccgctg cttcttttac ccccggtgct tgtcgaagaa 1860421 ctgtttcaat ctctctcagt tcaatacgat aacccctaat tttcacttga tcatcaaaac 1860481 gtccaatata ttcaatcgtt ccatcaggca aaaagcggcc tgcatcacct gttcggtata 1860541 aacgctcccc ttcaaggaat ggatgatcgg agaatgcttt ctgtgtcagc tcttgctgtt 1860601 tgtagtatcc tctcgcaaga cccgcgccgg aaatacacag ttcacccgcc gcgccgatcg 1860661 gctgcatttg atttccgtgc aaaacaaata cttttgtgtt tctgatcggg tgtccgatcg 1860721 tgatcctctc ttttttattc agatgccgca atattgttgt tgccacactg ttttctgtgg 1860781 gcccgtattc atttgccagt tcagcagaag gacaaattat ttgattcaac tcaagcagat 1860841 caggcgtgac cgcttcaccc gcaaatgtca caatacgaag actttttgca tcgtcagcag 1860901 tcatcacttc caataacacc ctgtacaggg aaggaacaat gatcatgtgg ctgaccttat 1860961 aacgggctat ttttcgctta agggccagca catccttcgc ttcgtcatct gttgtcagca 1861021 gtacgcacgc accagataaa agcggggtaa ataagctcgt tacacagccg tcaaacacgt 1861081 acgaaaacaa atggagggat atatcctgtt cggtcatgct atactcttcc cgtctccatt 1861141 gcaatgtatt ggcaataccg tgatgatcaa ctaaaacccc tttagggcgc cccgtcgttc 1861201 ccgacgtata gatcaagtag gctagatcac ctggcggcat atttggcgct tctgtttggt 1861261 aactttctgt atgttctatc gttatcgtat ttccttcata ggacggaggg atcaaggaaa 1861321 taaggtcttc ttctatcagc aattgagccg cttgactgtc cttcagaaga aaagaaagac 1861381 gttctgctgg aaaatgtgga tcaagcggca tataagcgcc gcctgctttc caaatcccaa 1861441 gcagagctgc aggcatttcc attgaccggc ccatcattac agcaacgata tccccagatc 1861501 caacgccttt ttctatcagg gcgtgcgcaa tctgattggc tcttacttgt aactggcgat 1861561 aggtccagca ctcgtttccc attttcaatg cagcagcttc aggtgttttg tgagcttgtt 1861621 cctcaaacaa ttggggtatc gttttgttca cataaggacg ctcagtttcg ttaaacaatt 1861681 ggataacctg ttgctcctcc ggcggcacga tattgatgtc actgacggca acatcgggat 1861741 ttgtcaaaat gcaatccagt gcttgcttta gatgcccctg aatcctcagc atctcctccc 1861801 gctcgtaaac gtctgcgttg tagctgaatt tgatataaaa tgattctccc ggaacgataa 1861861 cgatattaaa gtcgtaattg gtttgttccg acattgaaat gtcactcagc ttcagagcgc 1861921 cttcgtcatt ttcactctcc acgcttaatg cctgatgaag ctgtacaggg taattttcaa 1861981 aaacaaaaat atgatcgatc aacccttgct tcaatggact atggttttga atctcataaa 1862041 gcggataata cccatgctgt tcagatgata aaatatcctc ctgcacggct ttgaccagcg 1862101 aagaaaatgt tatgccttcc gcagatcgga ttcgcactgg aacagtattg ataaacaaac 1862161 cgaccattga ttcaatcccg tcaatcgctg acgggcgtcc cgaaatgacg gagccaaaaa 1862221 cggcatcatc tgcagcatta tatcgatgga gcagcacgcc ccaaatactc ataaacagcg 1862281 tgtttaatgt cactccccag ttttgggcag cctctgtcag tttctcaacc atatccggcg 1862341 ctaatgaaaa gctgacctgg tcggctttat aattcccgtc tgccgtgcgg cgctttattc 1862401 ggggaataga agcagtattg ccgtactcct tcaaatattc gctccagtag gcagcagtct 1862461 cttcttgatc ttgttctccg agccattcaa tataacggct gtacggcacc gtgctgccaa 1862521 gctgtacagg tgagttattt ttgagcgaat catacatgct gaaaaactct ttaagaataa 1862581 tgccgagaca ccacccatcc atgatgatat ggtgatgtgt ccagacacat gtatattggc 1862641 tgtctcctct atcaaaaagg gcaagacgca ttaaaggatc tttttgcaaa tcaaatcctt 1862701 tttcccgatc cttagtcata aaagcatcaa tcagcgtctg ctgttcttga tcagccaggc 1862761 gagaaatatc ttctctatat actgtcaatt cacggtttga tagaactacc tgctgcggac 1862821 ctgtaagatc tggtacttct ttaatgaaaa tcgttctgaa aatatcatat ctagaaacaa 1862881 gaaggtttaa gctcttttga aacgagtcga cgcatagatt ccctgtgatc gtaaacgagg 1862941 tctgttcgat atatgctttc gagctgaaat ccattagtga atgaaacagc attccttcct 1863001 gcatgtgcga taacggataa atatcttgaa tttgtgccga ttgtgccatc aattccacac 1863061 accttttcaa aagttaaaga tctttcacga gatcttcgat gctagataat gcagacaacg 1863121 ttaattcttt attgctgaaa tcgctcaatg ttttttcgcg tgcttttttc tgcgaacaat 1863181 gctcaatcgt ctcgataaga tgcctgtgaa aacgatccat aaagcactca attgagtgtt 1863241 tgctgaacac ttgggtgtat accgctttta cgtgaagccg tccgtccgta atgagagcat 1863301 tgatgtccag ctcatactct cgttctctct cacccgctat ttcgtaacgg ggctggtaat 1863361 atgataattg aaacgtttca acttccttct cttcgctaaa ttgaccgaga taattaaagc 1863421 tgacctcagg ctctttatgc cgcagttctc ctatgtgtgt taacaatccg tatccagttc 1863481 ctttgttcgg tactcttctc agcatatctt ttgtcgtctt aattcggtat gcgagctgat 1863541 cctcgaaagg ctcgggaata cccatgtcta gcagaatagg ataaatggag gtaaaccatc 1863601 caactgtcct tgaaatatca atgtttggca catgcccttc tctaccgtgt ccctcagtgc 1863661 tgatcacgat ttggtcatgc ccagtccatt cagaaagcgc cattcctaaa gccgtaagca 1863721 aaagttcgtt ggcatcagta ccataggctt gctgggtttc aaacagcaat ttttcagtcc 1863781 agtccccgga tagtacaaac gctgctgcgt cgctgttcat ttggagtttg tctggcacat 1863841 tttctatgtc cttaggaaga aaagcagtgt gagcgtctaa aatcgtttgc caatacgttt 1863901 tctctgaaag caattgttta ctttcagcta tttgggtaag accatcggcg taggataaat 1863961 aagaatccgt ttttggcggt aattggattt ctttcttttc taaagcctgt tgatatgctg 1864021 cagctaaatc ctcaagcaga attctccaag aaacgccatc tatcacaaga tgatgaagtg 1864081 caatcagcaa atgatcccct tctgccgttt taaacaaacc tgcttgcagt aagggccctt 1864141 tttctacatt cattttgctt tgaatgacgg tttcctcagc ggcaagtttt tcatcaagat 1864201 gagccctttc cagcgatgct tttgtccaat ctgaaatata aaggccaaac agttcatgat 1864261 ccttgtgatt gattccgcga ttaaactgaa tgacatggcc gttttggtca cgttggaaaa 1864321 tcatgcgaat ggcatcatga tgctcggtta ttttacgcag cgctagatga agcgcgttag 1864381 cattgaatcc tttttcactg aaaagcatga cggactggtt gtaatgatag tgaaaagcat 1864441 gtacctgtcc gaaaaatctt cgctgaatcg gggtgagttc agcttcacct tccgcaggtc 1864501 cctggtccgc ttgagatgcc aatggtgtga tatgtccgca tagttcctga atcgttgaat 1864561 aacggaataa gtcgcgtatt gtcatgctcc agccttcagc tgccagacgt gctgccactt 1864621 gtaatgcttt aattgagtct ccgccaagct caaaaaagga atcgtgaatg ccgactcgtg 1864681 acatgctcag tacatcttcc catatatacg ccatcgtttt ttgtaagtcg ttaactggtg 1864741 cggtatatgg acgcgataac acattatttg gagccggcaa ggcatttctg tccagctttc 1864801 cgtttagggt cagcggcatg tttactaaag gaatcagata tgcaggaatc atatacgctg 1864861 gcagttcctt tgttaaagca gcacggagag cattcgtatt gacgtctgaa ggcacaatat 1864921 atgctgccaa accagcctgt ccatttttat catgctgaac ggcaacagca gcttctctga 1864981 caagccccgt ttgaagcaga acactttcaa tttcttctgt ttcaattctg tatccattta 1865041 tctttacttg ataatccatt cggccaagaa gccggatcgt tccgtttgga agccagcatg 1865101 ctcgatcacc ggttctgtac agcctttctc cagagacaaa tggattttct gtaaatttca 1865161 tttgcgttaa gtcaggttta tgatgatagc ctttcgcaac acctgccccg ccgatgcaca 1865221 gctcgccggc aacaccgatc ggctgaattt gatcagtctg gctgagtacg tacatgtgta 1865281 cattcggcag cgggctgccg attggtacgt tatctcccgt acactctcca cccatactgg 1865341 tttcatagaa actcgaatca atggttgcct ctgtgacacc atagctatta atgatgcgca 1865401 tgctttggcc aaagcgatct gtcaatgttt tgaaatcttg agctttcacc atgtcggaac 1865461 caagaatcag tatgtctaag tcaggaagct tgaactggtt acggtataca tactccatca 1865521 ccgggataat gagagccggt gtcgactcca tcaccgtgat tctctgagat ttaatgattt 1865581 tatatatttc agcaggttcc agccgtgttt catctgggca aacgattaga gtcccgccgt 1865641 tggtcaatgt tctcgccaaa tctcctgaga agacatcgaa tgaaaagctc gcgatttgaa 1865701 gcagtctgac aggcttccga tccagttcat aaatttgacg ccaagcaaga gcagcatgag 1865761 taaagttctg ataggtgaca ataacacctt taggcgcacc cgtcgttcct gacgtataaa 1865821 tgatatatac cggctcttca ggagcaggag ataagttaag gttgcagtta ctttcttcaa 1865881 aagagccctc atcgtcaagg aagatgtgag acatctcaga ttcaggcgag ttcgaaatca 1865941 aatgcttcaa ctctctctgt aaaagaagaa tatctgcccc gctatcacga agaatgtatt 1866001 caatacgagc ttttggataa tgtgcatcga ttgggatata cactccgcca gctttcatca 1866061 ctgccagaac tccaacaatt gcatcgatgg accgcttggc taaaacagcc acagttggct 1866121 tcggtccttt tctgttttgc aatgttcgtg ccagacgatt ggctctttca tttagaaggc 1866181 gatagctaat ctctgtttcg ttatcaataa cagctatatg ttctggattt tcttcagctt 1866241 tcgcttcaaa tatgcgatga aaaggaatat ctttttgagc aaattcaact tgagttttgt 1866301 taaattcaaa gactattttt tgtttttctt tatcactaag tatgtttatt tgtgcaaggc 1866361 ttgtttcagg agttgaaagt gcctcatgca gaaattcgat aaaatgatca gcccagcgtt 1866421 caatcgtagc tttcaggaat acttctgtac taaattccat ttcgcagcaa atagatccac 1866481 ttatttccgt agctattaat gtgatatcaa ataaggaaat gtgatgtgcg aaattggcag 1866541 gccggacttt tatttctctc agatctatgt cttgtttttc cacattttga aggataaaca 1866601 tcgcatcaaa cactgggttc cggctcatat ctcgtgtcaa ttcaagctta tcgacaagct 1866661 cttcgaacgg gtaatcctgg tgctcaaagg cttccaatgc tgtctcacgc acttcctgca 1866721 aatactgtac gaatggcttc ccgccctccg ggcgcgtccg aagcgccagc gtgttcacaa 1866781 acatgccgag tatcggctca agatccttgt gcggccggcc ggcaattggc gagccgacga 1866841 tgatatcttc ctgtccgctt aagcgtgaca agaacgcggt gtaagccgca agaagcacca 1866901 tgtacagtgt gcttccgttt tcacgtgcca gcttgtgaag gcctgatgca acctcttgat 1866961 ccagcgtaaa tgagaccttg tcacccgcga agcttcgcac cggcgggcgg gcatgatcag 1867021 ccggaagatc cagcacaggc agctcgccct cgagctgctt cagccagtac gcctcttgcg 1867081 ttttgtacgc gtctcctgtt ttgaatcctt ctcgccatac ggcataatct ttatattgaa 1867141 tgcgcagtgc cggaagattc cgattattgt acagctcgcc gaattcccga atcagaatgt 1867201 tgacggaaac accgtctgaa atgatgtgat gcatatcaac cagcaacagg tgccgctcat 1867261 ctgatatctt tacgatttgg gcacggaaca gcggcgcttg gctgagatca aacggtttga 1867321 taaatgcggc tgcggcctcc tgttcggttc gttcgccgag aactgtagtc tgtaacgtaa 1867381 acggcacctc gtcatggatg cgctgcaccg gatcgcctcc tgcgtcctgt tcgaaggagg 1867441 tccgaagcga ctcgtggcgc ttgatcagct ctttgaaagc tctctccatc ctttcagggt 1867501 tgagcttccc ttcgagctct aacacagccg gcatattgta gcctgtccct ccgtcctcca 1867561 gctgctgaag gacataaatc cgcttttggg cagaggaaac cggataggtt tcctgttttt 1867621 cagcgggctt aatcgcttca tatggactgt ccgttccttc acggataacg gtagccagtc 1867681 cttctactgt cggatgggca aacacatctt ttagcggcac ctgtacatcg aattctttgg 1867741 cgatccgtga gacaagcgcc gttgctttta aggaatgtcc cccgcggtca aaaaagttgt 1867801 cgtgaatccc gacagggcca tttttcagca cgtcctccca cagctgagaa agcttcatct 1867861 cagtcacgtt tctcggcgcc gtgtaggtct ccgcatctgc cgctccgcca ggagctggca 1867921 gggcgtttcg gtcgagcttt ccgcttggcg taaccggcca ctgttccatc tctatcatat 1867981 aggctgggac catgtagccc ggcaacagtc tctcaagctg tgcacgcact tcgtttcttt 1868041 ggagcccttc tacataagcg cataattccg gctccccgct gtctgtccgt acggtaacag 1868101 ccgcctctct tacgccttct atgcttctta gtgccgcttc aatttctccc ggctcaatcc 1868161 ggtagccgcg gatttttacc tgatcatccg tgcgcccgag gaattcaaca ttcccgtcag 1868221 ggagccagcg cgccacatcc ccggttttgt acatgcgttc ccccgggtaa aacgggtctt 1868281 caagaaaacg ctcctccgtt aatgccggcc gattcaaata acctctggca acacccgctc 1868341 cggcaatgta cagttcgccg gcgacaccgg aaggctgtac ggctaaatgc ggatctaaaa 1868401 catacaaacg cgcaccaggt acgggcttcc caatcggaat ccgcaaacga tccctgtccc 1868461 gttctggatc caatacgtaa aatgccgcgt ctaccgttgc ttctgtcggc ccgtaaccat 1868521 ggattaatga tacctgcggc aatacagaag caaaacgggc tgccgtacgc ggcgcaagcg 1868581 gttcacctcc ggcgaataca cgctttaggc ttgtcctgtc actcagcctt tcgatttccg 1868641 cttgatcgag aaagctgttc agcatagccg gaataaaatg agccgttgtc acgttttcct 1868701 gatgaatggc ttgtacgatc aatgcggagt ctttctccca gccgggcgga agcagatacg 1868761 ccgaagcacc ggaaagcgac caccaaaaca gctgccacac agacgcatca aaggaaaaag 1868821 aggttttcac catgacaatg tcatcttccg aaagcggaaa ctggtgctgc atgccggtca 1868881 gaaaggaaac agcctgacgg tgctcaacgg ccactccttt cggctgcccg gtagagcccg 1868941 atgtatagat gacataggcg agagatccgc cgtcagcagg agtaaactca tggttttctg 1869001 ctttttcgct cgcaagagat gtcatgtcca cttcaagcgt ttcgccagaa aagtttggtg 1869061 cggagcatcc cggctgtgtc agcaagagcg atgccccgct gtctttcagc atgtagctca 1869121 gccgctcctt tggatacgca ggatcaagcg gcaaatacgc cccgccggcc ttcaatacag 1869181 caaggacagc gatcagcatg tcaggtgagc gttcagacag gacaccgacg atactttcgt 1869241 ttgtgacgcc gcgtgccgca aggtgcgcag ccagccggct ggcgtacata tcaagctcag 1869301 cgtatgtcag cgaaccgcct gaaaagcgaa tggccagccg ctccggtgtg aaagctgcct 1869361 gtcgctcaaa cagcccatgc agggtgaaag ctttaggcga aacagcttcc gtcttgttaa 1869421 actcatacaa caatttttgc ttttctcttg tattcgtcat atctaattct cttataaagc 1869481 tgtgcggatg tttaagggcg ttttccagta tggtaagcag atgagattgt attcgtttaa 1869541 tatcctcaag agaaaacaag gtattttgat agtcgaaatt taattgaatg gttccattgt 1869601 ctatccgttc ttgtatttga actgaaagtt cgttcgcggt gtatccgctg aaataaagcg 1869661 ctgtttcata gtcaaaatca tctgcattgt gccactgaag tggctgatac tgcatagata 1869721 taccgataag gttgtgtaaa tccttctgtt catttcttaa ttcatttaca agcaaattat 1869781 aaggaaaccg ttgatgacgc ataacagaaa gctgttccct gcctattgtg cggacaaagg 1869841 aaagaaaatc tgtgtcagga tcaaccgtta ttctgattgg aagggaacta acgaacatgc 1869901 cgagcatttc tttttcagcc tttgaacctc tgttgccata gtaggtgcca atggcaagat 1869961 cttttttaga agtgattcgg ctgatgcata tgtaaaatga agccataaat aaggaaatga 1870021 tattgatctt gtgttcttcg cagaagattc gaatcgtttg ctctagatca ggtgaaagaa 1870081 tgatggtgtc tctggatgca gatgtgctct gtttttgtaa ggacgtctgg tcggctaacg 1870141 agtggtattc caacgggtgc tcaaaggttt gcgtccaaaa taaacggtcc tttgcaaacc 1870201 gtggagattg tagatattga ctctcttttt cgatgtagct caagtaagaa ggttccggct 1870261 gatcaggtaa aggatctttc tttttcattt tttgataaag atctataatt tgatttccca 1870321 tcacatttaa agagattcca tccattatga tatgatggaa tttcgcaaat agccaaactt 1870381 catgagagtc aattctaagg aggtaaaatt gaaaaagagg cgagttgaac agtttaaatg 1870441 gaatgctcgc ttgatcctga atccattgct ctatttctat catttcaaca tttgaaaaat 1870501 caattattct aagtggataa tatttatatt cagtaaggtg caatcgaggc tcaagctctt 1870561 ctccttctaa cagctgaaat ctaatggcgt cgttgcggga gatggaatga ttcagtgctc 1870621 cctccagagt atcaagctca atattgcctt taaatttcac acaagctgta agattgcaaa 1870681 tgctggtatc tggctccagc agttcggtaa accacactct cctttgggca tgggttaaag 1870741 aataagtatg ttcgctcaac ggattccctc cagttctcat aataagagga taagaaaatg 1870801 tagaaaaaag cagaaaaatg acaataaaag aaattatatg actatataat ccatatatgc 1870861 actatattaa cggatatttt ttaaagtaca ataaaaaaca ttaaattttt ataacatttt 1870921 ttttgaatat agtattattt ctttattttt cgtttctttt tttatcaaat ttccggatat 1870981 aaagtgataa aagtattgtt ttacataagg tcttatacac tactttttaa tcggactaat 1871041 tttcttttgt gcatcattct tctaattgtt ggaaggttcg acaaagcgtt attacagaca 1871101 taaaaaaacc tgttttctct tggaaaacag gtctcccgct attattgatt tgccaaaatg 1871161 acagcgattt gatcctcaat atcttttcca tcctcttcat caatcaatcc atttagaaga 1871221 atagagaaaa caagtttttt tccgctcttt gtttctgcgt accccgatag agagcttacc 1871281 gtactgagcg atccggtttt tgctcttact tttccttgtg caggagtgcc tttcatgcgg 1871341 tttctcagcg ttccgcccac cattctgtca ggattccccg caacaggtaa agaatttaga 1871401 taagccgaga accaactctg atcctgaatg tcatataaca gctgtgaaag ttgatctgag 1871461 gatacagcat caatatgtga gattcctgat ccgtccctta agacgagtga tttagaatca 1871521 acaccaaatt ccggaagcgt actgtttaac acttcgagcc ccttttccca gctcccttct 1871581 ccttttttca ctttccccat ctcttttacg agcacttcgg catgtccgtt attacttaat 1871641 ttcatgaacg gcacaaaaag tttcgataaa ggcattgagc gatgagagag cagcacatct 1871701 gaagaactag gtgcttcacc cgtcttgatg tcccctttca cagtaatacc ttgttttttt 1871761 agtgactgct taaataaatc taaggcatat ccggcaggct cccagacaga aatccattcc 1871821 tttgtcttgt ttgcgtcaac cggtacgctc ccttcaattg taatcgtgtt tgttccatgc 1871881 tctctttcga ttgtgaggtc tttctctgaa ccggcagcag tcgttttagc atcgttcttt 1871941 atcgttatat aatcggtttt cggagagaca gacacggcag gctcttcccc ttctttttga 1872001 tttggggtga cctcaacaat cacagtgcct gcatcatagt cttcgtttgg agacgctgtt 1872061 agagcggaga ttggcgcgcc ataatatgtg tattcatcgc tccaaggcat atcaggtgat 1872121 aatcgcatgt catcatgcca cgtatcatca ccgatcagat tgcctttaat tacttttacg 1872181 ccggaatgtt tcaatatctc agccattttg tcaaaatcag atggtaaaag tgtcggatcg 1872241 cctttccctt tcaaataaag gttaccattc agctttttcc ctttcagtgt tccatccgtc 1872301 cggacctcgg ttgtaaaaga atagttctcg ccaaggacag aaagtgccgc ggccgctgtc 1872361 aaaagcttta gagaagaggc aggcctcatt cgggtgtctc ctgaatgttc atatagaaca 1872421 gcacctgttt ccgcagagcg aacggtgatg ccggccattg cgccttcgag ggcaggatga 1872481 tcagctaaaa tcttatcgat ctgcccggaa agtgcatctt gtttttcagc ggcaagcgca 1872541 gcctgatgca tataaggcac cgaagcaacg acgaaaagca gtaaaacagc aacataaagc 1872601 tttatgcttt ttttcattaa tttccccgcc tctctgcgct tcatcattgg ctattgatga 1872661 ttcagttcaa tggtgatact gcttttagct gtcgtttctt ctcccggctc cagcacttgt 1872721 aaaccagtga gtgacgaagg taaatcaaga ttcactgcgt ttgtcaccca tgtgtaaggc 1872781 tcagggcata aatacccttg ttttccgtcc gcattgtata caacccaatg tttaaactgt 1872841 tcatctgcct tataaataat gctgatatgt gcatgctgat gataaatgac tgcctggttt 1872901 tctccgcccc tcttctgata agaagataaa aagacatcat ccagctgctt gtggcgcaaa 1872961 tccattcctt catgcaaagc ttctttatac gggacatcca tcagcttccc ggtcggcagc 1873021 aggcgttcat ccaactccca ttgctgatct gctgtcaggg agaataacga gctttctgcc 1873081 ggaaatataa atgtagtatg ataaccaatt ccccaaggaa acgcttcctt tcctttgttc 1873141 atgaccgtcg catgtttaaa tagggtattc tccttgatcg tgtatgtcat ccgaacgacg 1873201 gcatgatgag gaaattgctt ctgcacatgg ggaagctcag aaagatcaat ttctgtttca 1873261 acaatcactc cttcatcagt ttgcttcgtg gtcacgacat tccacttttc atggtaaaga 1873321 aacccgtgaa gatggttgtg tttatccttc tcgttgatat caaaatgata cgttctgccc 1873381 cggaaactga atgtaccgtc acttatgcgg ttaggcggga acaggattgg aatgccatac 1873441 aatgttggtg tgtcgtgaaa actttctgct gtttccggtt cacgcaaaag ctggacattt 1873501 gttgttttgt ccacgagaga aatgacgttg ctcccccact cagggacaac aatcatttct 1873561 agatgttcgt tgcccgcttt gatggccggc gttcccaaat acgtgatttt ctcaataaag 1873621 tttgccatgt ttactcaacc tctccttgat tcattgctag tataagaatt caatgtactg 1873681 taccatattt cctccatttt atattttccc ctatcaaata aaaaaacacc gttcaaactt 1873741 atgaacggtg tgattcggag gctattggat gagacgtgtg atttgtttct ttttccagac 1873801 gaattgataa tacccataaa tcaacagcaa gctgacggca aacgcagctg gataaccaac 1873861 ccagacgccg agtatttcaa gctttgtata gtgagaaagg acgaaagcga caggcacctc 1873921 tactccccag attgcaaaaa tactgatgac ggtcggccat aaaactgttc cgcttgcccg 1873981 catcgttgca gaaataattt gggcatttcc aaacagcaaa tagctccaca gtgtaatcat 1874041 caaaagacgg tgcgcaatgt aaagcgtctc ttgctcggtt aaaaataacg ataaaatctg 1874101 atgtgaaaaa acatagatca gaatgatcag tacgccgcca atgatataat tcagccaaat 1874161 cccaacgcga atgacctgct ttaagcggtc aaactcgttt gctccgatcg attgcgcagc 1874221 gaaaatagaa accgcaatac caaggctgac ggccggcatc tgtacatagc tggccacctg 1874281 gttgaccact ccgtatgcag ctgttgcatt agagccgtaa tgattgacga atgaaataac 1874341 cgctatctct gataatgaga caagaatcat attgatgctt gctgggaccc caagacgcag 1874401 caggagaacc agcagttcct tatccatttt caaataacga cgcactgttt tatcaaattg 1874461 cagcgggtgt tttcgctttc gtaaatacac cattaacacg agaaaagtcg caatcgtgga 1874521 aatgacagtt gcatatgccg agccgtatat gcccagtttc ggaaaaccaa acatgccaag 1874581 gattaaaaca ggcaaaagcg cgatgttgat gaccgtgctc acaatcagcg tataaaacgg 1874641 tgtcttggaa tctcctgttc cgcgcaaaaa ggtagtatat gcaaaatata aaaacataaa 1874701 cggcatagca taaaataaaa tacgtgcata gttagcgctg acatgaatga cattttcagg 1874761 tgttcccatt aaacgaagga tatccagggt gaaaatactg ccgataacgg ctaacacaac 1874821 gcctaataaa aatgtaaacg tgagtgtcgt cccgacaaca gcctttagcc gttcctcatt 1874881 tttcgctccg taagcttgtc ctatcagaat cgaacttcct gaaccgatcc caatcgtaaa 1874941 tgagattaaa agaaaaaata acgggaaaaa ggatgataca gctgccactg catcaacacc 1875001 gagccatctg cctacagcca tcatcccgac tagctggccg actgattgca gcacattgct 1875061 cagcagaagc ggcactaaaa agagtgacat cgaccgccaa actgatggtt tgcttttctt 1875121 ttgagttaca agaggttctt gtgatgtttc catattaaag gactccttta tttgaaatcg 1875181 tttttaaaca tgccctcatt ttttgacaaa aacaggatat gtaacatgtt attattcatc 1875241 actgcactta tgaaaccctt cccgattctt ctaattttac acatcttttt agcttatgaa 1875301 gaataaacta gcaagtaatg gcgtattttt tgtgagtaaa agaataaaaa ataatttatg 1875361 caaaagtatt gtaatctatc cgtaattatt gtaacatttg taacataaga gaaagagatt 1875421 ttgaaggaga gagcgataat gaaaaaatgt cttctatttc taacaaccat tgcacttatt 1875481 ctgtcattaa gcacaaatgc atttgcgaaa aatacatcag gcgatttatc acaaaaacaa 1875541 gcattacagt tggcattatc cgctagagaa catttttgga acaccatgag cggccacaat 1875601 ccgaaggtga aaaaagcagt ttgcccatca ggcacattcg agtatcaaaa tcttcaatat 1875661 gtatacatgt gcagtgatct aggcactaaa gcaaaagcgg tgaattattt aactcctatt 1875721 tttacaaaaa cagcaatcga aaaaggcttt aaagattatc atttcactgt ttcaaaagga 1875781 aaacttgctg ttccaatcgg tgacggagac aatcttttga attggaaaaa atcaactgct 1875841 aaactgatct ctaaaaaagg cagcacaatc acatacgaat ttactgtccc tacattagac 1875901 ggatcccctt ctgcaaaacg gaaagtgaca tttgtgaaag aaaataaaaa atggaaagtc 1875961 aatcaatttg acgcagttat ataagaaaaa cgcccggtat aagcgggcgt tttttatttg 1876021 gtttgcataa agaaagacaa caggcgaaaa gtgcctgttg tctttttgtg aatataacgc 1876081 tctaggagag attcgaactc ccgacctgca gtttaggaaa ctgctgcact atccgctgtg 1876141 ctactagagc ttttggtatt tatatagtag ctctgatgat caatattttc aagcgatttg 1876201 tattaaagcc ctccaaaaac cttatatgcg gctcttgtcg tatcttcatc aataccgata 1876261 taccgcattg taattgatgg tgatgaatga ttcagtattc tctgcagctc ggcgatgtct 1876321 ttcgttcgct gataaaaatg atagccaaac gttttccgga gtgtatgcgt ccctatctcc 1876381 tcaagtccgc acgctgcagc ggcctctctt aaaattctgt aggcctgaat gcgggaaatc 1876441 ggcttcctgg tccgcactga tttaaaaaga tattcgtttt ccttcatgtc tttcgtatac 1876501 tcgtatattt cctgtttcag cgattctaaa ataagaatct ttcttttctt tttcgttttg 1876561 ctttcagtcg cccataaatg atctttattt tgaacgtcct tcacttgcag cggcagaata 1876621 tcagaaatac ggagcgcgct gttgatgccg aaaataaaca gaaaataatc ccgcttgttt 1876681 ttgttaagca aatactgttt gacttcttgg attttctcta gactgcgaat cggctgtaca 1876741 atatgcatca aaaaactcct taaaaaccgt tatgtaacat tttgaggtct atgttactat 1876801 tatagctgaa aaacgttgaa tgtcaaagtg cggcggcgtt tatgtaacat aatatacata 1876861 gtgttacata agcttttaaa aaagcttctt ccaaccttca ccctataaaa taagctttaa 1876921 agcctcttat aaagctttta acctcttgga tacttatccc cctactaatc atcaaaaaac 1876981 ctcttaaaat gaaatctgac actcccaatt ttctggagct tccgcaaaaa tatacaaaaa 1877041 aagacacaat ttcaaattgt gtcctaatcc tcatccttta catcaatatc ttccgggatc 1877101 ggttcattta atatttcctg cacaagtgct ttgtaattct ccagctgttc gagatgcgtt 1877161 ttgaactgtt ccttataaat caaaaattgc tccccgtcat gaacggctct gattttccct 1877221 tcgagcacca agcttttaat ataatcctct gaaagatttg tatattctgc tgtttcttca 1877281 atcgttaaat acatatagca gtcccttctt aatccgtatg ctgattctaa tatagcacat 1877341 ggctcatatc aatataatca attctgcaca gaaaaacggc attatgcact atataatata 1877401 ccatttgtca cttgtgaaaa cgctgtaatt tttttacgct aagattgtaa caatacagct 1877461 tcatatagga gggagaacat gaaaagaacg tggaacgtct gtttaacagc tctgcttagt 1877521 gttctgttag tcgctggaag tgtccctttt cacgcggaag ctaaaaaacc gcccaaaagc 1877581 tacgatgagt acaaacaagt agatgttgga aaagacggca tggttgcgac cgcacatcct 1877641 cttgcttctg aaatcggtgc tgatgtgctg aaaaaaggag gaaatgctat tgacgcagcg 1877701 gttgccattc aatttgcact caatgtaaca gagccgatga tgtcaggtat tggcggcggc 1877761 ggttttatga tggtgtatga cggaaaaacg aaggatacaa cgataatcga cagccgtgag 1877821 cgtgctccag caggcgcaac tcctgatatg tttctggacg aaaacggcaa agcaattcct 1877881 ttctctgaac gtgtaacaaa aggtactgcc gttggtgttc caggcactct gaaagggctg 1877941 gaagaagcct tggataaatg gggaacccgt tcgatgaagc aattaattac cccttctatt 1878001 aaactcgctg aaaaaggctt tccgattgat tcggtgttgg cagaggccat ttctgattat 1878061 caggaaaagc tttcacggac tgccgcaaaa gatgtatttt taccaaatgg cgaaccgctt 1878121 aaagaaggag atacccttat tcaaaaggat ttggctaaaa catttaagct tattcgctcc 1878181 aaaggcactg acgcttttta taaaggaaaa ttcgccaaga cgctttctga cactgtccag 1878241 gatttcggcg gatcaatgac agaaaaagat ttagaaaatt acgacattac aattgatgaa 1878301 ccgatttggg gagattatca aggctatcaa atcgctacta ctcctcctcc aagctccggc 1878361 ggtattttct tattgcaaat gctgaaaatc cttgatcatt ttaacctttc acaatacgat 1878421 gtccgctcat gggaaaaata tcagctgctt gctgaaacga tgcatttgtc atatgccgac 1878481 cgtgcgtctt acgcaggtga tcccgaattt gtaaatgttc ctctcaaagg cctgcttcac 1878541 cccgattata ttaaagaacg ccagcaatta atcaacctag atcaagtgaa taaaaaaccg 1878601 aaagccggtg acccttggaa ataccaagaa ggatcagcaa actataaaca agttgaacag 1878661 ccgaaagaca aagtagaagg ccaaacaacc cactttacag ttgctgaccg ttggggaaat 1878721 gttgtttctt atacaacaac aatcgaacag ctattcggaa cgggtattat ggtccctgat 1878781 tacggtgtta ttttaaacaa tgaattaacg gattttgatg cgataccagg cggagctaac 1878841 gaagtacagc caaacaaacg gcctttaagc agcatgaccc cgacgatttt atttaaggat 1878901 gacaagcctg tcctcacggt tggatctcct ggcggggcca caattatttc atccgttttg 1878961 caaaccattc tctaccacat tgaatatggt atggaattaa aagcagctgt tgaagagccg 1879021 agaatttaca caaacagcat gagctcttac cgttacgaag acggagttcc taaagatgtc 1879081 ctcagcaagc taaacggcat gggccacaaa ttcggcacaa gtccggtgga tatcggaaac 1879141 gtgcaaagta tatcgatcga ccatgaaaac ggcaccttta aaggtgtagc tgattcaagc 1879201 agaaacggcg cggcgatcgg cattaattta aaacgtaaat aaataaaaaa ctgtactcgc 1879261 ttcaaatgag tacagttttt tcatgcagat ctttaaaata aaaactgaca aacgtcttta 1879321 ttctgctaat gcacgtctat cttcatcttt tcatttcgtt tatctcatca agaaatgtct 1879381 gaaacgcact cgtaataaaa aagtctttcc tgtatataaa gacgatctct aagtcttgat 1879441 atgatggtgg cagctgatga atccatacat ttgtacgatg ctcggagccg tcaacagcgg 1879501 actttgggag cagcgccgta cccatcccgg cggaaacacc ttttataata gcctccaatg 1879561 tgccaaactc tatgattttt tgattgtgta tgcctgcttc ctctagtaat cttttgaccc 1879621 tgtcacgatg agaacagcca gccccaaaaa agagcatcgg ctgctgaagc atgtcttctg 1879681 ccgtcccttc tcgtgatgaa atcaaaacta attcatcatg ggagacatgg agttgtctaa 1879741 ctgcagcgtg ttcaaccggc ccatatacaa aagcgccatc aactttatga tcaagaacct 1879801 gttgaatcaa atgatgcgta tcagctgtgt tcactgataa atccacttca ggaaaacgcc 1879861 tgaggaagga tgctgcatgc tcaggcagat gcgttaccgc cattgtttcc agtgatccga 1879921 tccgcaaagg cccttttggt tgcctgctca ttcgggtcga tttttcagct tggtctaaca 1879981 gcgataatac ttgatctgca tattgtaaaa gattttctcc tgcagcagtc agcttcattc 1880041 cccgattcgt tcgatgaaaa agcctgatat tcaaatcttc ctcaaggtta tgcactctgg 1880101 ctgtcacatt cgactgaaca taattcagca tttgggctgc tttcgttatg cttccttcgc 1880161 gagcaacagc ctgaaaaatc tttaaatctc cgctttccac gcgctctcac ctgcttgcta 1880221 tgatgaaaag tgatattggc tatcatattt gttcatttta ctcgaagaaa accgctatgt 1880281 aaaatatgta aagatatgaa aatacaatta atgaggaggc agacagcatg aaagctgtaa 1880341 ttcacaacgg aaaagccggt cttctggggt tatcagttca ggacgttcca tcaacaaagc 1880401 ctggatacgg agaggtaaag gttaaattaa aatctgcagg cctgaatcat cgtgacttgt 1880461 ttcttatgaa aaacaaatct gaacaagatc ctcacatgat actgggttct gacggcgcgg 1880521 gtatcatcga agagattggt gaaggcgtga aaaatgttac tgttcagaca gaagtagtca 1880581 ttttcccgac attgaactgg gatttgacag aaaatgttcc acctgtacct gagattctgg 1880641 gaggtccttc ggacggaaca cttgctgaat atgtgatcat tccttcacaa aatgcaatca 1880701 aaaaacctgc ttatttatct tgggaagaag cgggcgtttt acctttatcc gctttaactg 1880761 catatcgggc tctgtttaca aaggggcaat taaaaaaagg cgagcatcta ttgatacccg 1880821 gcatcggcag cggtgtagca acctacgctt tatttatggc taaggcgatt ggggcaacag 1880881 taagcgtgac ctcccgcagt gaggagaaaa gaaaaaaggc gctgaaatta ggtgctgatt 1880941 acgcatttga cagctacagc aattgggatg agcagttgca gggaaaaaag atagatgttg 1881001 ttcttgacag cataggacct gccctctttt cggaatactt ccgccatgta aaaccaaatg 1881061 gccgtattgt cagctttggg gcaagctcag gggataatct cagttttccg gtgcgttctt 1881121 tattctttcc tcaggtcaat gttttgggaa cctcgatggg aagcggtgag gaatttcaag 1881181 ctatgctcgc tttcattgac aaacataagc tgcggcctgt aattgaccgg atatatcctt 1881241 tagaaaaagc atgtgaagca tataaaagaa tgcaggaagg cagacagttt ggaaacatcg 1881301 ggatcgtaat ggaataaaaa aagaaaccgg ctggcagcca gaccggtttc tcttatatga 1881361 taatcccctt tatttacgga agaactgaac tccccatcaa atatcgatcc acttcacgcg 1881421 ccacttcacg gccttcatta atcgcccata cgattaagct ttgccctctt cttgcatccc 1881481 ctgcggcgaa tacaccatcg atatttgttt gataatcccc atatgctgca ctgattttgt 1881541 tatttactga attaacaccg aactgtttca acagcggctg ttctgtgcct tcaaagccga 1881601 tagcgataaa gacaagctga gcaggccata ctttttccgt tccaggcagc tcgcggaact 1881661 cgtattttcc atgctcattt ttcacttttt ccatttggat ggtatgaagc tctttcagct 1881721 ttccgttttt atccgcgacc atttttgtcg tttgaatgga gtattctctc ggatctcttc 1881781 cgaattttgc ttctgcttcc tcgtatgcat attcaagcgt aaagacgtgt ggctgttcag 1881841 gccacatatt gtcattcgtg cgggctggcg gaagtttcgg gtgtttgccg aattggtgca 1881901 cgcttttggc tttttgacgc agagcggtag ccacacagtc agctcctgta tctccgcctc 1881961 cgattacgat gacatctttc cctttggcat caatgaattg cttgtcttta aaattagaat 1882021 ctaaatagct ttttgttgca agtgtgaggt agtccattgc gtaatggact ccttttgagt 1882081 cgcgtccttc gattaagagg tcccgctgtt tttgagcgcc tgtgcataag atcacagcat 1882141 caaattgctc ctttagctca tcagctgtaa tgtcaacacc gatttctgtg ttcgtgacaa 1882201 aatcaattcc ctcttgcgtc agcaatttaa ttcggcgttc tacaatgccc ttctcaagct 1882261 tcatgtttgg aatgccgtat gttaaaaggc cgcccgctct gtctgctcgt tcaaaaacag 1882321 tgacggaatg tcccgcttga ttcagctggt cagcactcgc cagtccggct gggcctgacc 1882381 cgacgatggc cacttttttg cctgttcgtt tttttggaat tctaggttga atccagccgt 1882441 tctcaaatcc tttatcgata atggtccgct cgatgttttt aattgatacg gccggatctg 1882501 aaatcgctaa agtgcatgat ccttcacaag gagcggggca tacccgccct gtgaattcag 1882561 gaaagttgtt tgttttcaac agacgttcca atgcttcctt ccatctgccc cggtagacaa 1882621 gatcattcca ttcaggaatt aagttgtaaa tcggacagcc ggatgtaaat ccgttaatgt 1882681 ccgcaccgat ctggcaaaac ggtgtaccgc aatccataca ccgcgcccct tgccgtttcg 1882741 atgcttcttc tgaaaaagga gcagaatatt ctttccaatc ctttaagcga gtgagagggt 1882801 cccgctccgc aggtttttct cgtttgatct ccataaatcc agttggtttc cccatgttcc 1882861 tctccccttc cttactgtac taccgcttgt ttttgtcccg atgctgctgt attctgcttt 1882921 ggcttcgtgt tggcctcaaa agcgaacatg atggcttctt catctgataa acctgcagct 1882981 ttttgctctt cgatgcttgc gagcatttgt ttatagtttt tcggaatgac tttgacgaat 1883041 tttttcacac tgtcttccca ttgatctagc agatcttctg ctttttggct gtttgtatac 1883101 gcagtatgtc tttcaagcat tgctttgatt tgctggattt ctttctcatc ctctaatgat 1883161 tcaaataaaa tcatctcaag gttgcatttg cgtttaaacg ctttgacatc ttcggtcagt 1883221 acataagcga ttccgccgga catacctgcc gcaaagtttt tgcctacatc accgagaacg 1883281 acaacgctgc cgccagtcat gtattcacag ccgtggtcgc cgatgccttc tacaactacg 1883341 ttcacaccgc tgtttcgaac ggcaaagcgt tcaccagcac gcccgttaat atatgcttct 1883401 ccgcttgtcg caccgtaaaa agccacgttg ccgataatga cattgtcatc cgaagcagag 1883461 ttgaatcctt ctgatgactt gacgatgatt tttccgccag aaagcccttt tccgacgtaa 1883521 tcatttgagt ctccgtccaa ataaagcgtc atccctttag gaacgaaagc tccaaagctt 1883581 tggccggctg atccggtaaa gtgcagcttg attgtatctt caggaagacc ttcttctccg 1883641 taacgctttg agatttcact gccggttatc gttccggcta cacgatttgt attattgatt 1883701 tcaatcgaaa tatcagcttc ttttccagat tcgatggctt cttgtacggc cgggagaatt 1883761 gttgtaatat caagtgattg atcaatttta tgattttgcg gcgattggaa cgtccgcacc 1883821 ccttcaggct gataaagaag ggtagacaaa tcaagctggc ttgctttcca gtgctccttt 1883881 gcccgttcac ttgcatgaag tacatcagtg cggccgatca tttcatcaaa tgtcttgaag 1883941 cctaacgcag ccatgtactc acgaacttct tcggcaatga acagcatata gttcacaata 1884001 tggtcaggat ctcccatgaa ctttttgcga agctctggat tttgtgtcgc tacaccgaca 1884061 gggcatgtat ccaaatggca ggcacgcatc atgacacagc cgagtacaac taacggagcc 1884121 gttgcgaaac caaattcttc ggcgccgagc aaggcagcca tcacaacgtc gcggcccgtc 1884181 atgagctttc catctgtttc taatacaaca cggtcacgaa gtccgttcag cattagtgtt 1884241 tgatgtgctt ctgcaaggcc aagctcccac ggaagccctg tatgtttaat actggttttc 1884301 ggagaagcgc ctgtacctcc gtcatagccg ctgatcacaa tgacatctgc agtcgctttg 1884361 gcaacacctg cagcgattgt tcctacacct gcttttgaca ccagctttac gctgattctt 1884421 gcgtcacggt tggcattttt caaatcgtgg atcagctggg ctaaatcctc aatcgaataa 1884481 atgtcatggt gtggcggagg tgagattaat ccgacacctg gcgttgaccc acggacatcg 1884541 gcaacccatg gatatacctt gttgccagga agctgcccgc cttcacccgg cttagcacct 1884601 tgagccattt taatctgcag ctcatcagca ttgacgaggt aatggctttt gacaccaaac 1884661 cgtccggatg caatttgttt gatcgcactt cttctatcat cgccgttctc atctggaaca 1884721 aagcgtttgg gatcttctcc gccttcaccg ctgttgcttt ttcctccaag acggttcatt 1884781 gcgattgcta aagcttcgtg cgcttcctta ctcaaggacc cgaatgacat cgcacccgtt 1884841 ttaaaacgtt tgacaatcga ttcagcggat tcaacctcct ccaacttcaa aggcttgcgg 1884901 tttccgtcaa atgcgaacaa gttccgcaaa aatccgatgc gttcttcatc agccgctttt 1884961 gtatactgtt taaacagatt gtaatcattt ctgcggcacg cccattgcaa agtatgaatc 1885021 gttttcggat taaacgcatg atgctctccg ccatttctcc attggaagtc acttcccggt 1885081 tcaagcgttt tgctgtaatc atcctgatac gcttcccggt ggcggcgctg tgcctcttct 1885141 gcaattgttt gtaaatcgat gccgcctagc tgtgatgcag tacctgagaa atagcggtcg 1885201 atcacatcgc ggctgattcc taccgcctca aagatttgtg cgcctctgta gctttgcaca 1885261 gttgaaattc ccatcttgga catcactttt acgacgccct cagtaatgct ttttccatat 1885321 ttgctaaccg cttcttcata gctgatatcc aaacggcctt catcaatttc ctgcttgtag 1885381 gtcgcataag cgagataagg gttaatcgca tctgcgccat aaccgattaa cgctgcaaag 1885441 tgatgcactt cacgtgcttc tcccgattcc acaataatgc tgaccttcgt acgcagccct 1885501 ttgcggatta agtgctggtg cagtgcgctt actgccagaa gcggcggaat tggtgtcagt 1885561 cgttcgttca tctttttgtc tgataaaatt aacaaactta cgccttggct gatggctttc 1885621 tctgcctgtg tgaacatgtc ctttaaaccg cgttcaagat cctctgaaaa cagcacatca 1885681 attttttggc tttttaaatc aggatgaaca atcgttttca atgcgtaaaa ctgttcattg 1885741 gataaaacag gtgtatacag tttaatccgg cgaacatttc gttcacttgg atgaagaaga 1885801 tcgccttccg caccgagcca agtcatcgtt gaagtgacaa gctgctcacg aatcgcgtcg 1885861 attggcgggt tcgttacttg tgcaaacagc tgtttaaagt agttaaacag cgattgcgct 1885921 cggtcagaaa gtacagcaag cggagcgtca ttccccattg aaccaagggg atctttgcct 1885981 tctttaataa caggaattag atacttttgg atatcctcat atgtgtatcc gaatgccttc 1886041 tggcgagtaa gaagatcact aaattgttct tcttctcttg actccggatc aggatttact 1886101 tgtacaagct cttcttcaag ccatttttgg tacggatact cagttgcaat ttgtgttttg 1886161 acttcctcat cggagataat acggccttct tccaggtcga ttaaaagcat tttcccaggc 1886221 tcaaggcggt ttttatataa aacgttctcc tgttcaactt caataacgcc tacttcagat 1886281 gagaaaataa tataatcatc ttttgtgaca taataacggg ccggacggag accgttccgg 1886341 tcaaggatcg ccccgatttg tttaccgtca gtaaatgaaa tagctgtcgg tccgtcccaa 1886401 ggctccatca gggagctatg gtactcgtag aacgcccttt tttccttgga catatgcgta 1886461 ttttccgtcc aaggctctgg aatgagcatc attgccgtat gtgccggttt gcgtccagcc 1886521 atcacaaaaa actcaaatgc gttatccaaa atggaagagt cactgccatc agcattgaga 1886581 atcggcaaaa tcttgtttaa gtcctcaccg aagctttcag aaacaaattg ctgctcacgt 1886641 gctctcatcc agttgatatt tccgcgaagg gtgttaattt caccgttgtg aaccaaatag 1886701 cggttaggat gcgctctttc ccatgtaggg aatgtattgg tactgaagcg tgaatgaaca 1886761 agcgcaaaag cagaaacgaa tgcttcgtct tgcagatcag aataaaatgc atcaacctgt 1886821 tcaggtgtta aaaggccttt gtaaacaatg gtctggcttg aaagactggc aaaataaaaa 1886881 tcaagacctt ccgttactcc ccaattttca gcctgtttac gaatgacata caattttcgt 1886941 tcaaaagata aattgtcctt tagatcagaa cttgcgccga taaatacctg acggacaaac 1887001 ggacagcttt tttgcgccac tgttccgatt tttccgacat ttacaggtac agttctccat 1887061 ccaagaacga cttggccttc ttgttcaatt agtgcattga tttgcttttc aatttttttt 1887121 ctttcatctt ccttctgtga gaaaaagacc attcctaccc cgtaacgttc tttttctggc 1887181 agattgatgt ttttgcactc ttttctaaag aaagcatcag ggatttgaac cagtaagccg 1887241 gctccgtctc ctgtatccgg atcactgcct tgccctcctc tatggtctag ctggcaaagc 1887301 atcttaagtc cttgtttgac aatgtcgtga gtctgcttgc cctttaagtg tgcatatagg 1887361 ccgattccgc atgcatcatg ttcaaattca ggacggtaga gaccttgagc ttttggcatt 1887421 tgattgtacg tcataattcc tctcccccga tcaatttccg ataataccgg tcataaaatc 1887481 taacaactct ataatcattg taggttttca aaacgatata aacaatatat aatttagatc 1887541 aaaagaatct caaaatgaga tagatggatg tgagacaaac atggagctgc gccaactgcg 1887601 ttattttatg gaggtggctg aaagagaaca cgtttcagaa gccgctgatc atttgcatgt 1887661 ggcccaatca gcaatcagca gacaaattgc caatcttgaa gaagaattaa atgtgacctt 1887721 atttgagcgt gaagggagaa atatcaaact cacgccaatc ggaaaagaat ttttaattca 1887781 tgtgaaaacg gcgatgaaag ccattgatta tgcgaaagag caaattgatg agtatcttga 1887841 cccgcatcgc ggaacggtaa agatcggctt tcctacaagc ctcgccagcc agcttttgcc 1887901 gactgtcatt tcagcgttta aagaagaata tccgcacgtc gaatttttgc tgcgccaagg 1887961 ctcctataag tttctgattg aagctgtcag aaaccgcgat attgatctgg ccttattagg 1888021 gccggtgccg acgaatttct ctgacataac gggaaaaata ttatttactg aaaaaattta 1888081 cgcgcttgtt ccattaaatc atccgcttgc taaacaaaaa acggttcatt taatcgattt 1888141 gcgcaacgac caatttgtat tgttcccgga aggatttgta cttagagaga tggcaatcga 1888201 tacttgcaaa caagcaggct ttgctcctct cgtttccacg gagggtgagg atttggatgc 1888261 gatcaaaggg ttagtgtccg caggaatggg cgttaccctt ctgcctgaaa gtacttttgc 1888321 tgaaacaaca cctcgtttta ctgtgaaaat tccaattgag ttccctcaag taaaacggac 1888381 tgtcggaatc attaaaccga aaaatagaga gcttgcgcct tccgcgaatg atttttatga 1888441 gtttgtcatt caatttttct ctaagctgga gcagtatcaa taaaaaaaat gaacccgagc 1888501 ttctatatag aagcttcggg tttttttctg caaattaatt tacaggtaaa gaaaaatcca 1888561 catggcaaac aaatgcttct tgatcaatta gagctctatt tgtcagttcc tttttctttt 1888621 ccggttcttg aagctgtaca gaagagtaat tgacgattcc aaggccgatt tccgtccctt 1888681 ttgaatccat cagccgaaca actgaaccgc ttttgaattt ccctttaatc ttctgtacac 1888741 cgtctaggta taaactcgat tgtccgtttg ttatttttcg tgaacaatca tctgataaaa 1888801 tcatttcacc ttccggaccg gaattaaaag cgatccattg ctccttttga ttcaacggaa 1888861 gcgttccttc tgcttcaaaa taggtgcctt ccgcctgttc atgaacggcg tggtataaaa 1888921 tatcgccagc atctgcctga cctaggaaac ctttaatgcc agacgccatt acgattttaa 1888981 acgcatcaag cttagagcgc atgccgccgg tgccaacgat gcttccagtg tcacctgcgc 1889041 atgcttcgat gtcaggtgtt atttcactca cccgctgtat ctttttcgct tctggatttg 1889101 tgcgcggatt gccgtcatat aatccgtcta tatctgataa aatcacaagc atatctgcat 1889161 caatcaatcc tgcgactttt gctgcgagcg tatcattgtc gccaaacttg agccgattga 1889221 cggtaactgt gtcattttcg tttatgatcg ggatgatgcc gcgctcgagc agtacattca 1889281 ttgtattcct gacattgttg tatcgatatt catcagaaaa atcgcttctc gtaattaaaa 1889341 tttgggatgc gacatagccg tgtgccaaaa acagctttga ataagcctcc attagcaatc 1889401 cctggccgat tgaagctgat gcttgttttt ctggaagctt ctcgggcctt tggataaatc 1889461 cgagcttccg atatcccgcc gccactgcgc ctgaggaaac caaaatcact tcataaccgg 1889521 cgtctttgag tttgacgacc tggtcgacca acgcttctaa ttttcgaatg ctgatttctc 1889581 catgaaggct tgttaatgaa ctgcttccaa tcttcacaac gactcttttc atgcttgtat 1889641 caggcgtcac tttatcactc ctgatagcgg cgctgcagtt ttttcgatat cttcgctgat 1889701 ttcctttgaa cgcttagccg catgctttat tgcttgagaa atcgcttctc cgccgccgct 1889761 ctttttcaag gcttgcagcc ccgctgctgt cgttccgttc ggtgacgtga tattatctct 1889821 taagatctca ggatgttctc ctgtttccat gagcattttt gcggcaccta aaagtgtctg 1889881 tgcgccgatg cttcgagata actgtttatc gaggcccgct tcctcgcctg tcttttcaat 1889941 gaattccatt aaataataaa aatacgcggg tccgctgcct gcaattccgg tgaatatatc 1890001 catttgattt tcttggattg tatagacttc gcccatgcat ccgagcaatg cttcggccag 1890061 cttcttcagg tcttccgaca catatttgcc aagggcaata gctgttgcag aagcgccaat 1890121 catactggaa gtgttgggca tcactctgac aaccggctgt tcattaagca atgattgttc 1890181 aataaaagag gtagttatgc cggcaaggac cgacaatatt aattgatggg gttgaatacg 1890241 tgattttagt gatgacagag cgttttcggc gtcttttggc ttcattgcca aaatgagcac 1890301 atccatgtct tcaatacata gttggttcgg caaggcgcct ttaatgccat attgaagttc 1890361 aagttcagtt aatcgctctg tattgctgcg gtttgtaacg cagatgtttt gtttcgggat 1890421 tttgttggct cgaacgatac ctgatatcat tccttccgcc atagatcctg ctcctataaa 1890481 ggctactttc ttttgatcaa agatcggtaa catctccttt gttcgctttt ttgttcgcat 1890541 tttcacacgt ttaaaatgtt accacgtgag gaaatgatgt caagtttgaa ggccattatt 1890601 gatttgtatt gtttcttttc gacaaatatg tataatgaaa agcagaaaac acccggttca 1890661 cactgctgcg ccgggtgttt gtttctatta aaaattatct gagagagctt tttcaatcag 1890721 ttttttacag cgatccagct ctaccttcag ctgtttttta tatagcttgg cagcttcgta 1890781 atctttaaat tgatagagga cgacttcctg gagcttagcc ccttcttttt ttactttaat 1890841 ttgttttagt atcccgtcat caagaagctc atgcaaagac cggtatactt ctgtatgatt 1890901 tggtttaaaa ccaatctctt taaattcaga ccgaagtact tcaagcagct ttaacccata 1890961 gagtctctct tgctctgtca tcgttatcat ataaagcttc aaaaatgcgc gctgtttcac 1891021 taaaaagcct gttgaactcc ttttttcttc tttcatcata tgcactcctt cttctgtcac 1891081 tgacaacact atgtactaaa tattcaattt tcttttattg ttttccttct ttatattaaa 1891141 gactgatagt ccagttattt catgtttact gattataggt gtagcggaaa aaataaattt 1891201 cgactgaaca tttggtacat agttttctta gttctattat agcctgcatt tactgctatc 1891261 ttcaatttaa acgattgcca gggtttacat atctcatttt accggtacgg atttcattca 1891321 aataaaaaaa cctgtcgaaa gacaggtttt catttttaag gatttgttga ccataatccc 1891381 gctgttttga tgaaaatacg aggatctaat ttcagttgtg ccaccatgta ctcagcaaga 1891441 tcctcaggct gcataacttt ttcaggatta ccgtctgtta agttcaattc gatagacata 1891501 tcactagcga cagtgctcgg cgttaacgcg ctgactctga tattatgttt tctcacttct 1891561 tgcataagag actctgttaa cccgagaacg gcaaatttag aagcgctgta agcacttgtt 1891621 acagcagctc ctctttggcc cgctgtagat gaaatattaa tgatgtctcc ggctttgcgt 1891681 tcgatcattt ccggaagcac cgcgcgagtg acatggtaca cacccattag gttgacttga 1891741 ataatatttt cccactcatc agctgacaga tctaagaaac cgccaaattt gctgatgccg 1891801 gcattattaa tgaggatatc gatatcaccg agctgttcct tcacttgagc tacagcttgg 1891861 ttaacctgat cggcatcttt tacatctgca gcagcaaatg cagcttttac accaagcgct 1891921 ttgacttctt cagccacttt ttctacatta gcggaagtcc ggccaattaa cccgatattc 1891981 acgccttctt tggcaagcgc cagagcagta gcgcggccaa ttcctctgcc tccgcctgtg 1892041 attagtgcag ttttatgttg taaactttgc aattgaagca ccctttcttt gtttacatat 1892101 gtacgatatc acattataag tacaatacat ccaatacgca aatcaaacga actgtgtaaa 1892161 tatcatttct tctgattaaa aaaacggata cagggtaatg acataagaaa aggagtgaac 1892221 atatgattat agtttatatc agtcttgcag tattagcagt ttctattatc ttcttaggag 1892281 ttaccgtgat ccaaaacaag aaaaaaatag accccgcact aaaggagctt tcctctgtta 1892341 cgcaggctat gcaaaaacaa atcgaaggat taaaaacaga aacagagctg ctgacgcaaa 1892401 aacaaaagaa gattcagcag gatgtccaaa taaaaaaata cacgcttcag cagaccgcag 1892461 ctgaagtgaa agaagttccc caagcagtca aagaggtgtg gcaggcagga cattttaata 1892521 gcagataagg atgaatgaga tcccgttgtt acgatcagaa tggacaaatg ggatctcatt 1892581 tttcgaggag gcttacacat gattataaac cgcagctgct taaaagagtt cgcagaaaaa 1892641 gtacattttc ttccctcttc acttacaaag tccgatttac ttactgatcc atttcgtctc 1892701 catcaagaaa acgaacttgg catctactat tcacctcata atgaatttat caatcgggat 1892761 gcctcgcttg tgattgccgg gatcacgcct ggtttttccc agatgaagac agcgtacgaa 1892821 acagccgccg aaagcctgct gcaaggcggg actcttgagc aaatggcagt agacacaaaa 1892881 atagcagcgg gtttctccgg atcgatgaga cataacctta ttaccatgct ggatttatgc 1892941 gggctgccgc aagcttttgg cattcaaagc gccgcaaagc tttttggaga attacggcat 1893001 atgctccata caacttccgt tattaaatat cctgtcttta tccagcaaaa aaactatacc 1893061 ggatacaaac cggctatcac tcattctcct atcctaagca cttatgcttt tgggcacttc 1893121 cctgcagagc ttaaccatgt gacgggacca gctcttctca ttccgttagg aaaagcggcc 1893181 gaaacagtgt gtgaaacatt gatcagacag cacagcctcc agaatttgat ttgccttaac 1893241 ggctttcccc atccatcagg cgcgaacggc catcgtttga aacaattcag caaaaacaaa 1893301 gagcaactag aaagacaaat tcgttccttt gctgcattgg ttgatttcgc tatagaaaag 1893361 aggaaataaa agggatatga taaacaaaaa cacaaacgtg gggagtggtt gaatgtttcc 1893421 tatattagaa acggatcggc ttatacttag gcaaatcaca gatcaggatg cggaagccat 1893481 ttttgcttgt ttctcaaacg atgaggtgac acgctattat gggcttgaaa acatggaatc 1893541 tatagaacag gccatttcaa tgattcaaac gtttgctgcc ctctatcaag aaaaacgcgg 1893601 tatacggtgg ggaattgaaa gacgggacac taaagaactg atcggaacaa ttggctttca 1893661 cgctctggcc caaaagcata ggcgcgcgga aatcggttat gaaatcatcc cggagcattg 1893721 gcgaaacgga tttgcatcag aagtcatttc aaaggtcgta tcttacggat tttctgccct 1893781 tggactgtcg cgtattggcg cagttgtatt taccgataat gaagcatcaa atcgtctgct 1893841 tctaaaaatg gggtttcaaa aagaaggcgt tttaagacag tacatgtatc aaaatgggac 1893901 tccatatgat acaaatgtgt actctattgt gaaaccaaga gaatgacggt attctcttgg 1893961 tctgtgccac atcccttttc ctttaaaaag ataaaaagcg cccctcaaac agggcgcttt 1894021 ctaattaaga tgcatattga ggagatgttt cctccttaac tgctttttcc tcaggtatat 1894081 gaatacattt tgtcaagacc gcacttgcaa ggtaaagggc cgcaaagatc cagacgacac 1894141 cttgcgcgcc gacgagaccg atgaacagcc aagcgagtgc agggccgaca aacgctgata 1894201 aacctgcagc taaattcaat acagacatgg ctgccccttt atcttttcct gccaccgtcg 1894261 gcacaattgc accaatcggc acatagcctg ccagcaaacc gccccaaata aagccgatca 1894321 cgctgacaac cgctaaactt ccgccggaga aaacaggtgc gtagtataat aagacggtga 1894381 aaatgccgca gccgactccg ccgaaccaaa taacagtatt tttccagccg aatttatcgc 1894441 cgacaatacc gaagataagg ttaaacacaa tgttccccag gaaaatcgtt ccccaaattt 1894501 gcagccacac attggttgaa attccatgct gggccatgtg catcggcaaa aagactggaa 1894561 aaccatatgt accaatgctg ttgatgattc tgatgattcc gcctgtaagc acgcgcggat 1894621 ttgtaaatag aatcgtaacc ccttttaaaa gctcctcggc tgtttctgat ctttttcttt 1894681 tcttcttttc aaaacggtct ttattgataa acaatgcaaa gaatgcaccg agacataccc 1894741 agaaaataga gctccaaagc gtattcaaat aaccgaacgc tttgatcgcg tagcttgagt 1894801 accaagcgcc gaacacaaac atgccgaggc aatatgcaat ccaaaaccag ccgacagcag 1894861 tgctcagttt gctttgcggt gttctgtaaa tgacccatgt caagaaagaa taagcaaaaa 1894921 gcgggtaacc taaccctttt acgaagtaag tcacatacat cactggcagg ttcagctgtt 1894981 caaatccaaa tacgataaaa gcagctgtac cgatcacata aaacaacagc cccataaaca 1895041 tcgttcgttt tgcgccaaat gcttcgagac atacacccga aaaccaggaa gctatggcaa 1895101 gcgcaattcc gtatatacta aaaatggaag cggactgctg aacggtgagc ccgttttcga 1895161 tcaaaaaagg actgagccag ccttgttcaa ggccatctcc catcataaac aaaacaaccc 1895221 ctaaaaatcc ccaggcaagc cgcttcggta ttcctatttt atccaacata tctgtctcct 1895281 ccttagatgc tattattcat taccgtatta ccttattaaa gttgaaaatt aaatgattcc 1895341 tcaaaacagc agaaattccg tcttaaatta atactttgct ttctgatcct gaaaaaaagc 1895401 gctgtgtttg cttccattcc tcatataaag ccaattctat ctgacagtcc ttcggttcga 1895461 tcacccggac atttgctgac atctcctccg ttaattgaaa ggtttcattg caaatgactg 1895521 cagcaccgac gacagatgcc tgatgatatc cctcttggac atagaccttt ttttgaagaa 1895581 gatccgcgat atattgagtg agcgctttgc tttggaatcc ccctccgcac acccaaacat 1895641 aatcacgttc aaacggagta acctctgtta aaatgtcaaa gttccatttg attgaaaatg 1895701 cgatctcttc tagcgctgca cgtacaaaat gtgccctctt taaatgtgct gacagcgggg 1895761 catcaaaaag aaaaccgcct ctcgttaacg cattcttttc agccgataaa taagagccga 1895821 gagccgctac acatgcatgg tcttcttttg caagtgcaga aatctcctcc tccattactt 1895881 cgtacgtttc attcggataa aaaatctgtt ttaatttttg ataattcaag ccggtaattc 1895941 ccggattcgt ttccacaagc caatgccctt gatccgtatg acagttcaac caggctttat 1896001 gttttgtgtc gccatgatcc tcagtaattt tggttattgg cgttgttgtc cctgatacaa 1896061 tgacaatgtc ctcaagtcca gctccggtgc ttttgacagc cagctgtgta tccccgcccc 1896121 ctgctataac cttagcattt attgaaaggc ctaattcgga tgcatattca tttgctatcg 1896181 ttccaattgc tgttcccgct cttacaagag gcggaaggat agatggagaa aagccgaaaa 1896241 tgtcgcacat ctcttctgac caagtgtttt gcttcacatc aaatagcagg gtttctgttg 1896301 cctgtgatgg ttcatatgtt aatattccgc tcagttggta cgtcacccaa tcactgatgc 1896361 ttgtaaagct tgcagtcttt tcccataaag agggctggcg ctgttttaat ccataaagct 1896421 tgagcgcaga aaaaagtgca gttggcaggc ggcctgtgct gctgtatatc tcttcccaat 1896481 cgggaatgcc cgcctcccac tctcggccgc gattatcgat gttcggcagc ccgagaaaag 1896541 gattgccgtt ttgatcaatc aaaacaatcc cctgtctttg gctcgtcgat gtcaaaccaa 1896601 tgatgtcaat atcacacgaa cgggatagcg cacgttttgc caaattcatc acctgcttcc 1896661 acagcacctg aggagaaaaa taacggctgt ccgggtaaag cgtctctgtg gaatactcga 1896721 tgtcctcccg ttcaactgtt agaacactgc cagttacact cacgaccgct accctcgcat 1896781 tgcctgtgcc aatatcaaaa acgagatagc ctttttgttt tttcattctg ttagcctcct 1896841 ttcttatccc cctgttttca gtgcgtcctt gttatacatt gtctgaatat taagagtttt 1896901 ttcacccttc cactttttga gggctttatt cagtatcgtc acgtgatgat cctccacttc 1896961 aaatgttgct ccagcgagat gcggtgttgc cagaacatta ggcaatgaaa tcaattcata 1897021 atctgattcc tctggaggtt catgataaaa aacgtctagt atcgcaccgc tgattttatg 1897081 ttcttttaat acaaataaaa gatcttcacg gtttacaaca actgctcttg aagtattaac 1897141 gaaaatcgca ctctctttca tcagatcaaa atattgccga tctatcagtc cgagtgtttc 1897201 ctcagtgcga ggcagatgga cagaaacgat atcgctgtct gaaaacaccg ttttaagaga 1897261 tgctttttca tacaacggat gatcgtcttg aatgtatgga tcgtaatatt ttatcttaca 1897321 gtcaaacgca gtcagcagtt ttgcaatcct ttgcccgact gcgccgaacc caatcatgcc 1897381 aaccgttttt cctgttagct catttccttt aaatttgaca taagcctgca ggtaatcact 1897441 gtcccactct ccatccttca gccactgatt cgaggcgctg gtatggcgca gaaaggaaat 1897501 cacatttcca ataaacattt cggcaacggc ttgtgcattc cgccctggtg tataaaaaac 1897561 aggtatgccc ctttttgagg cagctgccac atccacattt gagggcattc ccctgcaaac 1897621 accgacaaat gaaagttcgg gaacagaagc aaatacgctg tctgttacct gatcaagttc 1897681 agtaatcaag cctgtcgcat ttgttgcttt tagcagctga atgagttcat cctcccgata 1897741 tgccctacct tgttccttcc aagattgata agcaactgag ccaaacaagt tttcaagctc 1897801 ttttcgtcct tcttcgttgt acggtgctgt aaccaaaacc gtcatgctgc aaaacatcct 1897861 tttcatcgta tttttcataa aaaaaatctc tttccgaaga tggaaagaga ttcatatata 1897921 ggcgcgctct gttacaggca gacgccggta taaaccttgc tttcctatct ttcaagctag 1897981 cgcttgctgg aattggcaca ataatgttgc cgaggtttca tagggccagt ccctccacct 1898041 ctctggatag aaaatattga gtatgtaatt ttcagaatga agaatacgtt tatcataaag 1898101 aagactcaga ttgatgtcaa tctctttttt tcagaattga cgttatcatc ggaaatgtta 1898161 taattcttac aaaatatcta actagagaga ggaactgggc catgagatct tttgccacac 1898221 aacaaaacgg cattttcaaa tccgtttgct cgctggactg cccggatcag tgcggattgt 1898281 taatacataa aaaagacggg aaaatcgtaa aagtgcaagg agaccctgat catcctgtca 1898341 cagctggaaa catatgcaac aaagtccgga atatgacgga gcgcatctat gatgaaaagc 1898401 ggctgactac accgctcaaa cgaacaggtg cgaaaggcca agcgatattt gaaccgattt 1898461 cctggaaaga ggcaatcgat acgatcacct cccgctggaa acagctgatt gatgaagagg 1898521 gagctgaaag catacttcct tacagctttt acggaaatat ggggaaattg acagctgaag 1898581 gaatggaccg ccgctttttt taccgcatgg ggtcaagcca gcttgaacgg acgatttgca 1898641 gcaaagcggg atctgaaggc tataaatata caatgggcat aagcgcggga atcgatcctg 1898701 aggaaaccgt tcatacaaaa ctatttattt tttggggaat caacgcggtc agcacaaata 1898761 tgcaccaaat tacgatcgcc caaaaagcgc gaaaaaaagg tgccaaaatt gtcgtgatcg 1898821 atgtgcataa aaatcaaaca ggacgtcttg cagattggtt tatcccaata aaaccgggaa 1898881 ccgacagtgc acttgctctt ggcatcatgc acattttatt taaagaaaac cttcatgatg 1898941 aagcatttct gtccgagtac acggttggct atgaagagct ccgtgaacac gtgaaacaat 1899001 atgatcctga aaaggtatcg acgatcaccg gtgtcagtac cgaagatatt taccgactgg 1899061 caaaaatgta cggggaaacc tccccttctt ttatcagaat cggaaacgga ccccagcatc 1899121 acgataacgg ggggatgatt gtaaggacga ttgcctgtct tccggcgatc accggccaat 1899181 ggctgcacac agggggcggc gcaattaagc ataacagcgg aattttagaa tataacacaa 1899241 atgccttgca gcggcccgac ttattgaaag ggcgcacccc gaggtcgttt aatatgaatc 1899301 agcttggcag ggtgcttttg gaaacagacc cgccgattcg ctctctattt atttacggaa 1899361 cgaaccctgc cgtcgtcgcg cccgaagcaa acaaagtcag acagggcttg ctgcgggaag 1899421 acttgtttac tgtggttcat gatttgtttt taacggaaac ggctgcatat gcggacattg 1899481 tactgcctgc aacatccgct tttgaaaata ctgattttta cacctcctac tggcaccatt 1899541 acattcagct tcagcagccg gtgattgaga gatatgggga aagcaagtct aacactgagg 1899601 ttttccgatt actggctgaa gccatgggat tcacagacca ggagcttaaa gattcagatg 1899661 aagtattaat ccgccaggcg cttgaccatc cagataatcc gcatttggca gagattgatt 1899721 acgattcact tactaagcat tcatttatga aagcgaaacg tgaaaagccg ctgtttccgg 1899781 gcgaacttcc aacgccaagc ggaaaaatag aattatattc agaaaaaatg aaacaagacg 1899841 gcttccctgc tttaccgaca tatacacctc ttgtaaccga taatgaacat ccgtttatgt 1899901 atgttccggg gccaaaccat aatttcttaa actcaacatt ttccaataat gaaaaacaca 1899961 tcaagcttga aaagacgcca aagctcttta tcaacacaaa agatgctgaa aaacacggaa 1900021 tcgttgatgg ggcacctgta cgaatttgga acagccgggg agaatgcgag ctgaccgctg 1900081 cagttggaga acaagtgctg ccaggtgtcg ttgtcagcca aggattatgg gcggatgaac 1900141 aaggaaaaaa acagcttgta aacgcgctaa ccccagatcg cttgtccgat atgggcggcg 1900201 gcgccacctt tttttcaggc cgtgtacaga ttgaaaaggt ttgaaaaata atgaaacccg 1900261 gagtatgcca agcccgtata acataacatc gacataatgg aggcatacac atggacgttt 1900321 ttttaggaat tggtattgct ttggctggat attttatcgg tgaaggctta aagcagagga 1900381 accaaaccaa aggtaatgaa caaaatgata tcttcctaat aaaagaacgg gatatttact 1900441 tttacattgg acttttttta ggaataacaa cgactgaagc aaaacagtta gctggagaca 1900501 tggcagacct gccttacatc gaaataaacg gaaaaaaata tgtccagaaa catatgttaa 1900561 aagattggac attcacatta gttgaaaaac atcagggtga ataaaacaaa tctgaggaga 1900621 gcgagattca ttgtcacgct ctcctctgtt tagctgtatg gatcctgcca ccaaaacttt 1900681 gtgctataag cgctgataaa acgataaacc accatctatg ttctttcctc aaacaactca 1900741 agatgcccgt tccacaacaa tagtttttat attcctttga tgacgtgatg ttcttgatga 1900801 acgtatgtat cgtaaaacac ttagaaaacc tattcggttt gaatgtgtgc tctcattatg 1900861 cccccatact gcgcctttat ccgcggagga tttttttaaa aaaatatgaa acctaaagct 1900921 tttagatcct gaatttttat tgaacctcca tatttctccg attggtaaaa attagcctat 1900981 acaccggaag ctgtacgttt ataaaggatc agagaatccc ataaccagta aatcactgca 1901041 gccgcaatac ttaacatata ataaaagtac gattgcaatg tccatgctat tgacgcaggt 1901101 tcattgataa caaaaaacag gaaagctgcg ataaaagcaa ccacactgta aatcaatagg 1901161 tacatgacat tgaaagttct cgcttttttc tgcaacttca tttggagcgg aacagcaaaa 1901221 aggccataca ccacaaaacc gtataataaa gcaattgctg ccgtaaacaa tgcaattatc 1901281 atatcgccat acataacgaa agaataaaac cctaataaca aaccaaatgt aaggctggat 1901341 agccctaatg tcattaaata atatgatgcg atttttttca ttttttcacc ccccttgttt 1901401 gatttattca cagtgctgtt agtataaatt cacaaccttt gtatttcttt tatcgagatg 1901461 tcttccctaa cgtgctatac gcaatgcgct aataaaaggt ttcaaaaatg acgttctttt 1901521 attagataat acgctggctg aaaacgcctc tcctgattgg ccaaagcgcg aatgaaaaaa 1901581 gtgcatgaat acctgcccaa cagacagaat aagaagagtt gatatttcaa cacttttcgt 1901641 aaaggggtga aaccaatgag taagaaaggt attcaaaatt caagtattga acaaataaga 1901701 aatgaccatg agactgaaac agcttttaaa gcagatgatc ctaaaaaaca cggttccgat 1901761 cctaaaagaa cgaaataagt tcttaccccc actaaaatat caataatctg gaggaagtaa 1901821 agtgactcaa aaaaacggtg cagacagacc tgatgattat aaaagatttt cttcattaga 1901881 caaggaatat gattttcagc aatctatacg cagcaatact gagacagaaa gtgtaaacac 1901941 tgaaacacaa actcataaca aagaaaacaa aaatgacaca acagatgttg ccgggaaata 1902001 ctttgagccc tcagattata aaggaagcac gcaattagaa aaaggattgg ctgaaactca 1902061 tgaacaggtc agcgatgact attttgaagg gacaatcgat caaaatttgg actagccata 1902121 caaacggaac taacttaaaa gaagtcagtt aactctgttt ttagaaacaa ccacagtaaa 1902181 agtagccaac ccccaccgaa taagatgggg gttgcacgta agtagcctgt ttaatattta 1902241 aaacgattaa tgacggtttg aagttcttct gccaactgag atagagattc tgcggcatag 1902301 gagatttccc ccattgaatg aagctgttcc tgtgatgaat ttgcaaccgc ttctgtattt 1902361 gctgacgttt cttttgtacc agcagccaat gtatgaactg tgtgctgaat cacttcaacg 1902421 cctgaagtaa gctgttgagt tgctgctgca acttcttgta tttgagaagt gacctgttcc 1902481 accaggttca gtatttcatt gaaatttcct gttgtctctt gagaaagaac aatacctgag 1902541 ctcacatttt cttgaacaac tttaatatta tttaccgttt ctatcgattc gttttggatg 1902601 gtcgctacca ccgattggat gtggtttgca gatttatttg tttcatccgc caacttccga 1902661 acttcttctg ccaccacagc aaatcctttt ccttgctctc cggctctggc cgcctcgatc 1902721 gctgcattta gtgccaacaa atttgtctgc tctgaaatcg tcgtgataag cgaagagata 1902781 tcgctgattt ctgctgtgct cgctaccaat gtttgcaatc cattgccggc tgaatctaca 1902841 gatttatcaa tgaatttcat ctggtctaac atcttgttga cggacttaga gcctatttca 1902901 gccttgtctc tcatcgaaga agaaagatcc gctatgttcc ctgtatttga agcgactgat 1902961 gatatactgt ctaataattc agtgatggat tctgcgctct tttctgtcat tgagctttgc 1903021 ttcacattgc tgtcggcagc catctgcatg gctcgtgaaa tatgttcaga tgttgatttc 1903081 gattcttccg cgcttgccga taattcttca gaggaagcgg cgacttgttc agatgagctg 1903141 ctgatctgct tcacaatttg agttaatgaa tgagtaaaag aattaaaaga ttgggcaagc 1903201 tggccaaatt catctttatt tttcacaatg acttttttgg ttaaatcagc ctcgccgtgt 1903261 gcaatttcct ccagctgctt atttatgctt cttagtggca ccataatgga ctttaacagc 1903321 attatgctta gaacaatgcc taatattact gatatccctg tgacaatgat aatgagcgat 1903381 tgactcattt tcccattgcc ctgtatttca tcctttagat cctctacctc ttgatccagg 1903441 cgatcagaca gcttattgac agccggagct acgccttctt ttcttattgt tctttcttct 1903501 ccaaaatgga tggtttctgc ttttttagga tttgaagagt aggctgttac tacttgctga 1903561 ttcaaagctc tatactgagt aaaacttgtc ttaatgtctt caatattgga ttgatacttc 1903621 tcttcatcaa tcaagtcatt aacccggtca aggctcttta agacatcgtc tgcttttccc 1903681 ttcataccct cgtcgtattc tttgtctctg gtaatcaaga agcctctttc atcatttgat 1903741 aacccggtca attcatattg gatgtgtttt atctcttttt ggaattccat tttgtcttta 1903801 agttcttcat tctttttcac agtagaagaa atcataaata ctgaggagcc tccaattcca 1903861 ataattgaaa caactaatat tgatataatc cccagcaatt ttgttttcac tttcatgtgt 1903921 cgttttccct ttccgcacaa tgtaatggct gaaataaaat atgttcaagc gcgtttgaat 1903981 ccaattcgct tacgctcatg tccataatat cgacacgtgt tatcaagttt tatagtgata 1904041 ttcttatatg aataagcaaa ttctttacgt ctctgaactt acagaaaaac cttaagtaaa 1904101 atttgcagtc ttttgcggta tgtaagtcac tcttattcgt ttttctaaaa aaggcttttc 1904161 ccacctcaaa ttggctgaac cggctgtttt ctcgaaaata taatacaata cgcagcataa 1904221 tatgaaggag cgaaacttaa atggggatca tcaatggtaa agaattcatt gaccgattga 1904281 ataaactaga aaacgaaata tggtatgatg gcgaaaaaat aaagggtaac atttctgagc 1904341 atcctgcatt taaaggaata atcaaaacaa aaagctcact ttatgaattg caaacaaagg 1904401 atgagttaat acatgaaatg acttattgcc ttcctggaga tcataatcga atcggccttt 1904461 cctatctcca gcctaaaaca aaaaatgatt tgaaaaaaag aaggaccatg attgaacatt 1904521 gggctagaca tactcatgga atgatgggga gaagtccgga ttacatgaat acggttatga 1904581 tgagctttgc ttcgtcagcg gagcttctaa aagataaaga gaattgcttt cctgaacata 1904641 tactagatat gtatgaacaa gctgctaagc atgacctttc ctttacccat acattcatta 1904701 ctccgcaagt gaaccggtca cagtcctatt ttgggctaag tgaaaaaccg atatctgcta 1904761 aagtcattga tagaaccgaa aaaggtttaa tgattcatgg cgcacgactg cttgccacac 1904821 aaggcgggtt gaccgatgaa atcttggttt tttcagcgcc taaatttttc tttgaaacag 1904881 atgaagctta tgctttttca atcccttcta atacaaaagg cgtaaaattc atcacaagag 1904941 aatcatttgt attaagcgac tcttccttta atcatccctt aagctcaagg tatgaagaaa 1905001 tggattcaat tgtggttttt gatcatgtgt tagtgccgtg gaatcgtgtg tttttttacg 1905061 ataatgtgga agcagctaaa gattttatga caaaaagctc ttttcatgcc tttacctttc 1905121 accaggttgt cattaggcaa atgataaaaa ttgaatttct attaggtgtt gcacagcttc 1905181 ttgtcgacac cattaatgtt tccgaatatc agcacatcca agaaaagctc tcagaaatca 1905241 ttgtgggatt ggaaacaatc aaagccctca ttgacaaatc ggaaaatgat gctcagttag 1905301 atgaattcgg ctatatgcgc ccctgtttaa ttcctcttca agtcatcagt acgatcattc 1905361 ctaagctata tcctcgattt actgaaatca tacaattaat tggagctagc ggaatggtga 1905421 cactgcctac cgaaaatgca tttgactcag agatacggga agatcttgac caatatcttc 1905481 aagcaaccaa tacaaatgct gaagaacgtg tgaaaatttt ccgtttggca tgggatttaa 1905541 caatgagttc attcggaact agacaaactc actacgaaag atattttttc ggagatccta 1905601 ttcggatttc aagcaggctg tataccagtt atccaaagca ggagcagttg aacatgatta 1905661 aaacattttt acatgcagat acagaacatt gaaaaaacag cgggaaaaga tccgctgttt 1905721 cgtatttttt attcaggaaa ctgaacatgg cccggtactg tataggcttt ggacgttccg 1905781 ctttcaggca gctttggaat ggtgtctttc acaacttttc cgcggatgtc agtcattctg 1905841 actttgagag agccagtacc taaattcgta ctcacaaaat ggttatagtc cattttctcc 1905901 atgttgatcc acttaccatc cttttcatat tccattttca taacaggata cttgtgattt 1905961 ctgacttgga ttgctgccca ccacctgctg ctgccttctt tgatccggta cgtgaaattg 1906021 ccggtgattg gggctttgac aacacgccat ttaatattga tttttccgtc tttcatattg 1906081 ccgattttac ggaaggcatt aggtgacaga tcaagagctc cccgagcgcc ttcgggataa 1906141 agatcagtaa catatacggt tgttttccct tttggccctt caacttccaa ataagagccg 1906201 gcaagtgccg cttttactcc tccgtaattg agatccgccg gatttattgc agtaatctcc 1906261 atatcggaag gaatgggatc cagcaggaaa gctcctcctg aatagcctga ccctgtatac 1906321 gttgcataac cttcatgcag gtcgtcatat gctgccgaag cttgcgggga aaaacagaag 1906381 atcgtcaaca aaaccatacc aacaaatgca ctcatgatct ttttcatatt tggtcctcct 1906441 caaaccagac ttcaaatgag aatcattatc attataagac tcaatccatc tggtttgaaa 1906501 gaggaaatag attcatagtt gattttaagg caaattcact atcattcata tatcaaatgt 1906561 aggtacttat gaaaaagcca atacaaatga acgaatgtgc acttcagccg aatgtcttat 1906621 ttttccctct caaaattcgc atttcaataa cgaaatgaaa caggctgttg gcctgataac 1906681 agctatacag gaaaagctat ttttccccgc tcagtttcaa cttagctgtc atcatgatgc 1906741 caaagatcag cacaatcgga acccaaataa tgaagtgata aaaatcaggc tcagccagag 1906801 caacaataat agcccctaca caatacaaaa taatagccag tgctcttaac acagtatctc 1906861 ttaagaaagt cttcttttgc ttcttaaaaa acaaacggcc ggatatatcc tctaaaagag 1906921 aagccaaagt gccggtcaac acagttgaag aaatacctgc aatccccagt ttttttgctg 1906981 ctgtagtttg aatccccata gaaatgctca tgagtataat tagaatgtgc acaggaacaa 1907041 atgcccggta aaaagaaaga caagcaaaga caaacaaaat gaatgcttca agtgcgaggg 1907101 cttttgtcac agcagaaggc caaagggtat tttccgcctt tccgaccatc aatgtagcaa 1907161 tgatcacgcc gcatataaat ccgattagcg cagtcaagga attaaaaaca gtgacctgaa 1907221 tggatttgcc gatagctaac cccaataata caatgtttcc agtcatatta gctgtgaaca 1907281 catgtcccag gcttaaatac ccgattacat ccacgattcc agctgttaaa cataaaagtg 1907341 atagcaaggt gtttcgataa gctgctgcag tcaacggtgt atcaatcctt tcttctattt 1907401 caattgttag tatgtctttt ggcgcaatct ctatttttta agtaacccaa cattaattag 1907461 gaagatagaa cctattattc ctttccatta actgtaataa taatccccgc aaggaaatga 1907521 ttaaaattga aaggaagcat attgtgatga aacgactttg tttatggttc accgtcttta 1907581 gcttgttttt ggttctcttg cctggaaaag cattaggtgc agtcgatttt ccgaatacct 1907641 caacaaatgg ccttttaggt tttgccggaa atgccaaaaa tgaaaaaggc atctctaaaa 1907701 cgggcacaac gggtggaaaa aacgggcaga ttgtttacat tcaaagcgta aatgatttaa 1907761 aaacccatct aggaggatcc actccgaaaa ttttagtgct tcaaaatgat ctttccgcat 1907821 ctgcgaaaac aacagttacc attggctcaa ataaaacact cgtgggctct tacgcgaaaa 1907881 aaacgctgaa aaatatttat ttaacaactt catcagcttt tggaaatgtc atttttcaaa 1907941 atttaacgtt tgaacacagt ccgcagatta acggaaataa tgatatccag ctttatttag 1908001 attccggtat gaactattgg attgatcacg tcacattctc aggtcatagc tataatgcaa 1908061 gcggaagcga tttggacaaa ctcgtgtata tcggaaaatc cgcagattat atcacgatca 1908121 gcaactcaaa atttgcgaat cataaatacg gtttgatttt aggatacccg gatgattctc 1908181 agcatcaata tgacggctac ccccacatga caatcgccaa taattatttt gagaacttgt 1908241 atgttagagg cccaggtctg atgagatacg gttactttca tgttaaaaac aattacagca 1908301 ataattttaa ccaggcgatt acaattgcta caaaagcaaa aatatattcc gaatataatt 1908361 actttgggaa aggcagtgaa aaaggcggca tccttgacga caagggcact ggttatttca 1908421 aagacatagg cagctatcca tcactcaaca agcaaacctc tccgctgact tcttggaatc 1908481 ctgggtcaaa ctatagctat cgtgtccaaa cgccggaata tacaaaagaa tttgtcacga 1908541 aatatgccgg atcacaaagt acaactctgg tatttggcta ctgatataaa agaggccctg 1908601 cgttaaaaac gctgtgcctc tttttatact ataggctatt tttaagcgat ccttgtaatt 1908661 ccatcaagat ccagcgtcgg tcaaactaaa aagcatatgt tcttttccac aataacttct 1908721 taactggctt tcttattata ccagtttatc gcaagtgaaa agaaatcatt gttctgaacc 1908781 tgtattaaat gaacgatcgt cccacaaact acttaaaaac ccctaaaaag gatgatggat 1908841 atgtgcggca ggtttacttt gtactctgca tttgatgata ttattgacca gtttgacatc 1908901 gatcaatttt ttcctaaagg tgaataccag ccaagctata atgtcgcacc atcacaaaac 1908961 atccttgcaa tcatcaatga tggatcaaat aatcgcttag gcaagcttag atggggactt 1909021 attccacctt gggcaaaaga tgaaaagatc ggttataaaa tgatcaatgc tcgagccgaa 1909081 acaattaccg agaaaccggc ctttcgaaga ccgcttgtca gcaaacgctg catcatacca 1909141 gcagacagtt tttatgaatg gaaacggctt gattccaaaa ccaaaatccc aatgcggatc 1909201 aaattgaaat catctgctct ttttgcgttt gctggcttat atgaaaagtg gagcacacat 1909261 caaggatacc ctctttatac ctgcaccatc ataacaactg agcctaatga gttcatgaaa 1909321 gatatacacg accgaatgcc ggttatattg gcccatgatc atgaaaagga gtggcttaac 1909381 cccaaaaata caagccctga ttatctgcaa agtttgctgc tgccttatga tgctgatgac 1909441 atggaagcat accaggtttc atcattagta aattcaccca aaaataattc agctgagctt 1909501 cttgatgcag aaaatcatat gtagtgattg aaaaaattct ctagcaagaa cttgtcaaat 1909561 agctttgttc cttaggtgcc aatccctcta gtaattatga atatttagta catagatcaa 1909621 ttagttatct ttagcatcag tttgaaataa ttttattatg taaacttaaa taagcaatgt 1909681 tattcctttc atataaaata gtttacattt ttataaaatc gcttcacttt tctattttgt 1909741 cagcaaaaaa actgaaccac attaaactta tgaaacctgc cgcacctgtg gattgcaaat 1909801 atgatataag cccatagagg taaatccata cactttccct cctaagaatt aaatgaaatt 1909861 tctttcatct tacatgaagg tcttctttct tttgtttatc cagtgtaata cttaataata 1909921 tgttgatgaa tgcagctgga aaatatataa atcccactcc aagaatgcct agtatcgtac 1909981 ttaaacttac tatgtaattc tttgtcatcg tttgactgtc aatcaatatt agaagtgaaa 1910041 tcaatccagc taaaacacct ataaaccaag catcgccaac agcataagaa tcatccagca 1910101 tccctaacca tcgccccaat atagagctcc caatggcagt caaactggat aaaaatatga 1910161 gtgctttcat ttcttctcct cctttaaagc caatcaaact ggtagaaatc ggccattgaa 1910221 tccccattat cgaatggtta ccatttcatt tccacattaa cattttaaag ctcattacaa 1910281 tacgattcaa gcagaaaaac cctacataac gtatatatag ggatttaata aaacacaggc 1910341 caaaattcag ctctatctac tttaaaaaga tatgaagggc agctgtgtga tctgttacgt 1910401 ctttacgtac cgggatattt cacaacaggc actttcttct tgcgcagaga atcaagcatg 1910461 actgatccag cattcaagtt gctttgtact aattctttag gcgtcaatgc catccactga 1910521 ttgagtgaca catctgcata gcggttactt ttgaacattt ctaaaaacca taatgtttct 1910581 gtaccagtgt tttgtatata gtgtccggca ttagaaggca cgtatccaac gtcgcctgct 1910641 ctataatcaa atgtgcgggc agtcccattt ccgataaata ccgtcattcg tccctgtcct 1910701 gttagataat attgccactc atcgctattg ggatgccaat gaagctctct catcgcgcca 1910761 ggctcaatct gaacaagtgc agcggctatc gtttttgaaa ttgggaagtt agaagaatcc 1910821 acaattcgta cactcccccc tggcatttga attgggggtt gatttaacag ctcgtgttta 1910881 aaggtcatgg ggacttttcc atatggtgac tgaatgtctt cactggcgac tgatcccggc 1910941 acattccctt ggtagatata gacttgctca gacggaagag agttgaaagc attctccggg 1911001 acaccgaaat ttgcagacag aacatctttt ggtgtgtgtg caagccaatc tgaaatggtt 1911061 aacgttgaaa actcagaaaa gttcccatca tcgaaaacga gcagaaactc gcagtgttcc 1911121 aatccctgta tggaatgcgg aattcctgcc gggaagtacc aaaggtcgcc gggaccaaca 1911181 tcagcaatga aatttcgtcc gtcttggtca acagcggtga tacgtgcccg tcccaaaagc 1911241 atataagccc actccgcttg cttatgccaa tgaagctcgc ggacgcctcc cgcagttaag 1911301 ctcatgttta cacctgcaat cgcagtcgaa atcggaagct gtcttacggt gatttctctt 1911361 gaccagccgc cgtgatctaa tttcatggga gcgtctgaga atgaaaatct caagttagga 1911421 atcataccct catctgtaac aggcggaaca aatatattcg gattttgaat atcccgtatt 1911481 atatttcgcg ggcctgtatc aatagctcca gctccatcac ttcgaatagg ctgcggcacg 1911541 tttctgtctt catgattgat tggttgttgt tccaacagca tgcacctcgt tttagaaatg 1911601 aacaagattt tatttcagcc tatgcagaat cttagattgc tgtgcctagg aatccgcaaa 1911661 taaaaaagtg accaccaatg tgatcacaaa tacatcaaat aaactatttt ttataccatg 1911721 gcttcttatg taatttgatt gcttctgtct gttttttctg gcctgtcctc cactccactt 1911781 ttactaatac atcatgacct atcacttcat cttcaggcat ataatcaaag gtggaaatat 1911841 ggtcctccat gcgtccccca cccggcattt catcacctgt gtactccgat aagtcgtact 1911901 catctacgtt atcatcttga tacttttcgc catctacata cagagtaatt ctttcaacaa 1911961 cagtccactt ttcttccttc ttactcccct gccaatatag atttagaaaa taattgggtc 1912021 caattgaagt tttgtctgat ttttcaaggt tagacatcca cagtccgctt ttcccgctgc 1912081 cctcatattt cactttgttc cctgacacca ttacaaataa tgtgatgatg cagatgatca 1912141 agaatccagc aatgatcaat agccatttct taatattgtt cttttttctc atgtttttcc 1912201 tcactttcct aactttttag taggaaaata cgatcaaaat gttaccgaaa agaaaataag 1912261 aaagggctaa tgatctaaca gatgactgtc taaacttttg acttaaatta aagtgctttc 1912321 taaagacaag attaaaacgt ataacagctc ttaaatgcat tttttgtttc attgagtcaa 1912381 gaaccttaaa atggcttttt attattaaaa atcaagctag tgtattaagt aacttttcaa 1912441 atttatttat actcatgatc tcgtgagtca caaatctccc atcaaaaaaa acgctaaaag 1912501 ttgtccaaat agctggtgac ttttgtgcct cttctttcga tgataactga attgactgaa 1912561 attgaacccc tttcttttca gtcaattccc gcaaatcatt tatcatgccc actgcaaacg 1912621 gacactgagc tgtatagtat atcgtaatcc ccttttcatt gatagaatca cttttcacct 1912681 ggctcttaaa tgcaggagaa tctgcaaggc cattccaagt caaagccatt aattgaaaat 1912741 aaggggcagc ttcatcttgt agagtaaacc ccatatgctc aaagaaatgc ttatcactta 1912801 aatagggcag ttttttcttg cctgcgatat ggataatgcc atccatgccg cacgctttcg 1912861 catctgctat acatttgtcc aacaatcgtt tcgcatgacc gttattttta tatctgccag 1912921 acacccacag acaattaatg tacataaaat taggcgcatt gataggcacc catgcctcat 1912981 tcgcaggtag gtattcaata aagacttttg cccgttcatg taagcgatag aacaccaatc 1913041 cttcatccat tcgagctttg agccatctct tcttttcatt aactgcatgc tcatattgtt 1913101 tcgtgcttaa tgcacagcaa atatgattgt cttcaatatt gtcctttgtg atttcaatgt 1913161 agcacatctc ctctttcccc cctttaacat aattacatgg aattcaactt cacactttac 1913221 atgcctaata gaataaatac ccgttccaac ttaaatactt tttcttttcc attttgccaa 1913281 ttaactgtaa aacccttctt ttattcagat attatcttga ttcctatatc acccatttca 1913341 aatccaaagt gtgttcatct ttgaggatta gatgcactgc ttatgctata aatacagtac 1913401 acgaagtttt ttatttgaag taatatttgt tacgggacag caatagtaaa taagtgataa 1913461 aaggggaatt aaacttggtg gaaaaatgtt attcttgttt aatttgcgga tacaaaggat 1913521 taattcaaaa tcctttgtat aaaggcgagt atcaaaaaac gtttgacatt tgtccatgtt 1913581 gcggttttga atttggctac agtgaggatc atgatgtgag gttaggtttt attgtaactc 1913641 ctgatcattt aattgaggct gcatttcaat tgtatcgcaa acaatggctt gagagcggga 1913701 tggtaattgc tcatccggaa gatattccag aagaattgaa aaatggcaat tgcttaaaat 1913761 ttgaagtttt gttgaaacaa ttgaaaaaac taaatcttga catagaaaat tttgaaatta 1913821 gcggttttta atgatgaaac aggttgcact tgtttaggtt tcactgtcat tatcagtaaa 1913881 atgttaagtt gaaatgcgca atcagtcaca aagtctctat tcgtattcaa taaagacttt 1913941 gtgatcatcg acaaacattt cactcccatc ggataaagta tccaaaaggc ctcctctggt 1914001 tcttctctat agtcattaat cacagtcact ttgacatttg actcagctat gattggtttt 1914061 ccaacaattt ttcgtttttt cctcaggcaa agtaagagat cgaatcatca aagccattcc 1914121 atctttactg tctaattaac gccatcttca gtgaatttaa aggtctgttt taaattgcgt 1914181 ccttcttgcc ccttctgtgt ccaaattata acaacctcta attcagaggc cttatctgcc 1914241 agcataaaat gattgaactt cagcggtgag ccatcattta aactttcagc taacatttta 1914301 gaatcttctt ttggtttgac acaattttca tcgggacatc caaaaagcga aaaccttgtg 1914361 attgaattag ggtcatttct atacaattgc acatccactg tagctgcttt ttcccctata 1914421 tttttgactt ccaaggaata tacttgatat tctcctttat gaggtctcgt aaattccttt 1914481 acattttttg cttcacttac ttttactgac cactggtctg ttttttgtgt aataggcaac 1914541 accgtaaaag tcagggcatg cgcttttgat tggcaaaacg taaatccaac tgctgtaaaa 1914601 acaattacag aaaataatac ccttttcact tcatttatcc ctccttcctt tcactggccg 1914661 ctccttaaag aattgatttt gagcaatcta caagctctct taaccaaaac cttacctgag 1914721 gttttgtctt tactgctctg catttatttc tttcggtatc cgagaaggag ctttggggat 1914781 ttttctcaat ctgctgttaa tcacatcaga agagtatagc gtaataatca tacttccccc 1914841 ataccttttt gcccgaatta agattggttg gttatattgg ttttgaaagc gaaagtcagg 1914901 acctccccag cttaccgtcg catcccgtcc gggcggtaca tatggtacac ttctagtatg 1914961 agaatagcgc tgaacgatct gcagtcctgc acgatctact gcattaaata gagttgagga 1915021 cacctgacaa attcctcctc ctacaccttc agacaactcc ccttttacaa taatgggtgc 1915081 acttttatat cctttgttcc gagttctcat tcccacaact tggttaaacg aaaacgtctc 1915141 attagggaaa acaacgtgat tgtcgattgc ttttgcagaa agagaaatat tgtgtgaacg 1915201 gcttttattg cttgagttaa aatacgtcac gtactgacca agctgctgcg tactgatgtg 1915261 agctagcagc tcgctgtcaa ctttcggata aatgttcatt tccggcactt ctatcttgga 1915321 gggaccttgc ccataaaaat acgcataaaa cttttccata aacgcctgtt gatacagttt 1915381 gtagccaacc ctgcccggga cgatgcttcc atgatcgtta aggacagcat ttatcggctc 1915441 acggtacact ttctgatcaa gctgtttgat gaatttactg tatttttcat agtcaaccat 1915501 tggagtgccg ggaagaggca ttgtaaagtc ttcacggtta acagtggcaa tcgtccgtcc 1915561 ttgctgtgtg accgttaaac tgtcctgcgg ctcactcggc tgagccaata aaaaaagacc 1915621 agtgatcaaa atttgtatca taagtcggtt tacctcccaa tcattagtat gaacagccgc 1915681 ttatcctttg atgtatttct tcccatcgtt tgtttgaatc tttagacgtt gataaaaacc 1915741 ttcataaaag agcttagctt tatgttcaca ccgatccctg agctcactga ggcacacggt 1915801 tcattcagtc ggcaagtttg aagtagttca gcatctccca gtgatgaggg atgctttttt 1915861 gtcttgtcaa aaatgaaaag ggtctcctat aacaacaaaa aatcaatcca tttcaatatt 1915921 tttttattga gaaacgataa attttttgtt acattcaatt agacaacaaa taaatgaggt 1915981 gcttgttatg aatcgaatgt cgacaatttt tttaaagata gctttggttc ttattggaat 1916041 tccaattctt gctttatgca tttttttagt gcctaaggta gccaactatt cagcagaatt 1916101 atttccaaat atcgcttata taaaatatct cgttttcatc tatttgtatg taacggcgat 1916161 acctttttac tttgctcttt atcaagcgtt caaactttta agctatattg acaaaaacaa 1916221 agctttctcg ggtttgtctg taagagcttt gaagaatata aaatattgcg cagtcactat 1916281 cagtatcttt tacgcagcag gcatgcctgt cttttatctg atggccgaga tagacgacgc 1916341 cccgggtatc attgtgatcg gattggttat tatttttgct tcaatggtga ttgcggtctt 1916401 tgctgctgtt cttcaaaaac tgttaaaaga agcgattgat ataaaatcag aaaatgactt 1916461 aacggtctga ggtgatgaca tggcgattat tatcaacatt gatgtgatgc ttgctaagag 1916521 gaaaatgagc gtaacagagc tttcagagag agttggcatc accatggcta atctttcgat 1916581 attaaaaaac ggaaaagcaa aggctattcg attatcaact ttagaagcga tttgcaaggc 1916641 tttagaatgt cagcccgggg atatattgga ataccgaagt gatgaagaca caggattcgt 1916701 aaagaaaaaa tatgaaggat caacagaaaa ataaagtgat tggcggtgag cttatggaca 1916761 taaacttata tccatctagc tgctatacta agcgtccctt tcatacacga agaacacaac 1916821 tatggaggag gcatacatca tgagagccat aaaacaaatc gtccattttg gctgggaaca 1916881 agccctttca tgtttgtttc ctgccgttat ttttgcctct ttggctatta cgcaaatcat 1916941 cccactgccc ttcttgccgc ggtatgactg gctgctcatt atctgcgttc tcatgcaatt 1917001 gtggatggtg cgttccggtc ttgagacacg ggatgaatta aaagtgatca cattattcca 1917061 ccttattggg cttgctctgg aactttttaa agtccatatg ggctcctggt cttatccaga 1917121 agaaggatac tccaaaatat ttggagtacc tttgtatagc ggctttatgt acgcaagtgt 1917181 agccagttat ttgtgccagg catggagaag gcttaaggtt gaactggtta agtggccgtc 1917241 tttttttgca gttgttccgc ttgccgcagc gatttatttg aattttttca cccaccattt 1917301 ttctatagac attcgatggt ggttatcagg gcttgtcatc attgtctttt ggcaaacatg 1917361 ggttacatac gaggtgaatg gagctcgtta ccgtatgccg ctcgcacttt cttttatact 1917421 catcggattt tttatatgga tagcggaaaa tatcgctacg ttttttggag cttggaaata 1917481 tccaaaccaa atcgatacat ggagtctcgt acaccttgga aaggtaagtt catggctctt 1917541 gctagtgatt gttagctttc ttatagtagc atcattaaaa caagttaagg agcagagtcc 1917601 cacaaaggca gagatggatg aatctttttc ttagcatacg catacaagct cccaaataga 1917661 gtgaaaagca acgttcaaat ggttgctttt ttcttttatg taactctgcc ggtgagtatt 1917721 catcttcttc aaatttcatc gcaacacgat aactgattca gattacaact gctttcaaca 1917781 ctttgacaaa ctcatgcgcc gccggcgtta tctcttcaaa tgaatgtgcg atgacgccaa 1917841 tatcgcgtgt gaccctagga aagatgtcct ttttaatcaa ttgatgcggg acggatgaaa 1917901 gtgtaaagtt tgaaatgatg ccgataccca agttattttt gaccatatta atcaaggttt 1917961 cggcattttg cacagttaag ttttccttta attcgatgtt gtattgcgaa aatgcgtttg 1918021 acatcgcgat ttcatgaccg cctttacaaa aaatgaggtc atcttgatat gtttcaaggt 1918081 cgacatgctt ttcaagtttt aattcgtcac gctgcggcgg gatgacggcc accatatagt 1918141 cgttacacaa tagctgattt tcaaacggtt caaatggaga tgctgcgatc ccgatatcaa 1918201 ccgtccgatc ttcaacccat ccttttattt ggtcagaggt tccttcgatc aattctatgc 1918261 ggatcagcgg gtagtttgat ctgaatgccg caatcgcctg tggcatgata tttgttgaaa 1918321 ctgcaggaaa tgaaccaatt ttcaccttcc cgtttaacag cttgttttcc cggttggcta 1918381 cttgatatat tttgctttca attcccttca tttgcctcgc cagcagcaat atttcttttc 1918441 cgatgtcagt cagcattaaa ccatgatgtt tatccctgat caataatttg agctgcagtg 1918501 agctctccag gttttttatc gctttactta ccgccggctg agagatgaac aattcttttg 1918561 ccgcttctgt aatatttaat ttctccccaa cttttacaaa tatgtgaaga tggttcatgt 1918621 tcataaccat ttggttatac ccccaataat aaaaatgtat ttcagttata cataaatgta 1918681 acatatgata gaaaccagca cgatatttta acaagaaagg cggcttcatt atggtaaaag 1918741 ttatgctggg aatcatatct gtcacactta tttggggtta tacttgggtt gcgatgaaag 1918801 taggaattca tgacatcccc ccgcttttat tttcgggttt gcgcctgttc atcggagcag 1918861 ttcctttatt tctcattctc ttcatccaaa gaaaaaagct ttcaattcaa aaagaacatc 1918921 tcaaaagcta tatcatcatg agcctgttga tggggctggg ctatatgggg attttgacgt 1918981 atggaatgca gtttgtcgat tcagggaaaa cctctgtttt ggtatataca atgcctatat 1919041 ttgttacggt gatcagccat ttttcattaa acgagaaaat gaatgtgtat aaaacgatgg 1919101 gactggtctg cggcctcttc ggactgttat ttatatttgg aaaggaaatg ctcaatatcg 1919161 atcaaagcgc tttatttggg gagctgtgcg tacttgtggc agcgcttagc tggggaatcg 1919221 cgaatgtgtt cagcaagcta caattcaagc atatcgatat tattcacatg aatgcctggc 1919281 accttatgat gggagccgtc atgttattgg tgttttcctt tatatttgag gcggtccctt 1919341 cagccgagtg gacatatcag gcggtgtggt cattgctgtt taatggcttg ctttccaccg 1919401 gctttacctt tgtcgtatgg ttttgggtgc tcaatcaaat ccaagcgtca aaagcatcca 1919461 tggcattaat gtttgttccc gtattggccc tattctttgg atggctgcaa ttgcacgaac 1919521 agatcaccat caatattatc ctcggcgcac tgctgatatg ctgcgggatt tttatgaata 1919581 catttacatt ttcacgacgg aaagtgtgaa tgatatacat ttcccctgtc atttgggctt 1919641 catgtgacag gagaagacta ttacgagaaa gtcttctaga atcctgacga cagcctatta 1919701 aacaatgaaa aaagctaatg tctgcatgta gacattagct tggctggcgt ttaggctggt 1919761 gagaatccag atactttttt attaccattc tggctgatca aactgaaaac cgtatagacc 1919821 ttttacttta acatctccgc aatctggatc ttttgtcaaa atcaaataat gagtcttata 1919881 aggcatcgtc tcaactcgat cagttgcact aaaatcaaaa tgatcccccg agaagttttt 1919941 ttcactaacg gttatttcat atcctgacaa agtcattcgc atgattcttg cgttaattgt 1920001 acatccttca gtatcgaaaa tggtgaatct gtacccaaag tgagatgtcc aatggtttga 1920061 atttaggtca tcagacttca taaaccattt ttcattctct gtcattgtaa aactcacttt 1920121 ctcctcatct ttcacgataa cggccgaagc ttcccctaca tggatagtca aagccaaaag 1920181 aaatgtaaaa gctaacatca acatcttttt caaaagagtt cctcccgata tcttttactt 1920241 caatatattg gaagggtctt ttctgatcaa gacagtcttc tccaaatgaa tctttagcac 1920301 catgaaatga gccttaataa gaacagtttt aacccaaatc aacctctatt cgaaataagg 1920361 cttaccaatc tatattcttt ttaaaagttt ctgcatttct ttatttagct cctagacaca 1920421 tataaaaaat gctcctataa gttcaggagc actacaaaaa actgctaaag tgttttctat 1920481 cgatttattg tattcattag ctcaaagaaa tattcaggct tttgagtctt atttagctta 1920541 taccatgaac gcaatgtatc tggtgcaaat acatctaatt ttttcaatac ttctaccgca 1920601 aattccagag gagcaattcc tgatgcagta accaaatttt catcagatac tgcaggcccc 1920661 ttttcataga atgtttctcc tttgtaatta gggcagacca tattcatata gtcgaggtca 1920721 ttgcttgtgt gctttctcga atttaagtat ccttcattcg cgaggcccaa ggttgcccca 1920781 caaattgcag caatagtcgt gccgagcttt aaagcgtcgc caactttttt caagatcggc 1920841 tgatgaatat cttctcccca agtgtttcct ccgggtaaaa tgataagatc ttgactccca 1920901 agagtacatt cgtcaagaga aatatctggt tttatgctta atcctcccaa cgtagttatc 1920961 atttctttat taacccctac tgtaactact tttaaagatg ctgcatcttg tttaaagtat 1921021 ctccctgagt ttagttccgc aattaaatat ccatattccc agtctgacat tgtgtgaaat 1921081 acgtagagat aaacttttct cgtttgcatc caataacact ccaatcacaa ttgataaagc 1921141 tttctaatag atgactttgc tgacagtcat tgtcagcttt tttgttgatt ctattcttat 1921201 gcccttgttc tcccaactta taaaaatata agatcaattg attctatgtt tactagcgca 1921261 aaggggtttg ttacactaac tgtcatggga aacatttcaa aggtaataca aaatcatttg 1921321 aatgaggagg cctgatgaag ttgaaaacta aagcgtcaat aaaattcgga atatgtgttg 1921381 ggcttttatg tttaagcatt actggtttca cacctttttt caactcaaca catgccgaag 1921441 caaaatccat agaagacaca aacatggcaa gctgtataac gaataaaaaa tttgttcaac 1921501 ttgagaaaaa atttgatgcc aggcttggtg tttatgcaat tgatataggt tcaaacaaga 1921561 caatcgccta tcggccgaat gaacgatttg cttacgcatc aacctataaa gttctagccg 1921621 cagctgctgt cctgaagaaa aactcaattg aaaaacttaa tgaagtcatc cactacagca 1921681 aggacgatct tgttacatat tctccaatca cagagaaaca cctagataca ggcatgagcc 1921741 taaaagaaat ctcggaagcg gctatccgtt acagcgataa taccgctggg aacatcttgt 1921801 tgcaacagct tggcggccct aaaggttttg aaaagtcact gaaacagatt ggggatcatg 1921861 taacgaaagc taaacgattc gagacggatc taaactctgc gattcctggt gatattcgtg 1921921 acaccagcac cgcaaaagca ctggcaaccg atcttaaagc cttcacttta gataacactc 1921981 tcacgactga caaacgcatg atcttaaccg attggatgcg aggcaatgct actggtgacg 1922041 aactgattcg ggcaggcgct ccaataggat gggaagtcgg cgataaatcc ggagccggaa 1922101 gttacgggac acgaaacgac attgctatcg tttggccgcc aaacagagct cctattgttg 1922161 tggcaattct gtcaaaccgc tttacgaaag atgctaatta tgataatgct cttatcgctg 1922221 aggctgcaaa agtcgtcctt aacgatctca aataatatgt ttagcctttt gccacaaagg 1922281 aaaagacatt acttttttaa cttctaccgt tcattttttg atgaacggtt ctttcataag 1922341 acctctagaa tcatatattt aaacaccaca aaattaaaca ttattataat taacagcaag 1922401 ttttcatttt atggaacaag taaagtttga atctgacaag aattaagact aagcacccta 1922461 aaatccgttt tcttttcttc caagaatata ctccttagtg caagccatta taaagataca 1922521 agtgaacata caatgcagac aactctctta agtctcttat tctgtgacca atttgtaata 1922581 ctcatgaata tccggactca cttccaatat ttcgtctcgt tcgaagacac taacatatca 1922641 aaccacttga attaacataa ctgaacttga tattggtcac tggcagtttc aatgcaatag 1922701 aacaacattt gttgtctcag aggttatcta tatgagaatt caacaatttt tttataataa 1922761 ttcatatttt tgtatcgttg cacttggtgg atttgactct tttcgtgtat ggaaccacac 1922821 ttttattttt tcacctcttt tgagatcatc tgtgttatca atctcactta atcctacaat 1922881 tactatgtta tttttaaact tgttcataag ttgtccttca gaaagattgt aatcttcttt 1922941 tcctggagct tttgtatcgg taatgagaat tgccctttca ttgtctttaa gcacgacata 1923001 gcctactagg ctctgcatct ttgtttcgtc tccgttttgt tcatttttat tgcagcctgc 1923061 aaggaaaata atgagcataa tgagcactat caagcttact ccgattttag gcatctttct 1923121 tcctcctctt taaactcatc tttaaaataa acaacaggat atcacccaac ccatctactt 1923181 ctttttgcaa ttcataacag cagcatactc attctccaat tcctcaacct tctttttatt 1923241 ctttctcaaa tatttgcatg tggtagccct cgatattatc cgcttactca tttttgcgct 1923301 ttcaaatata ttattgaagg ccgcttcttt ctggattcca gcataaatat acttatcctt 1923361 actgtcgttt actatcgcaa cttccattaa aatcgagatt tttacttttt ttatgatcca 1923421 ttattcactt ccaaaataac ttccaattac aacataatat atgtataaat tgtaaatgga 1923481 gttgatgtaa ttgaagatta ggaaaatctt attgagttct gctttatcct ttggcatgct 1923541 aatatccgcg gttcccgcat tggctgctgg cacttcgtct gaggttgcag taaaaaatga 1923601 agaatatgat tatgacacta tataccgcat tagtcctctg ccaatggact tccagccaac 1923661 aatagaatac aacggttata cttatacgct tacacgtcat tattttgatt actcaatcgg 1923721 gttttacacg gctatttata caaaagttgt ttaaacttat aaaggagctt tttagctcct 1923781 ttttctcttg ttttaagcaa ggtatttctt tctatgtggt cccctatcaa atacaacatc 1923841 aacattctcc agttctcttt gacacgaaca aaatctaaag tttggtttta aatgctggta 1923901 ataaaaaatt cactttaaag aagtgccgcc cgcaaaatac ggcttttgta cactacgcca 1923961 attttatatt gaaaagccag acctcctcaa agaggttcca gcttttctta atgtgctatc 1924021 gatcttcgtt agttcaacgg gaactttatc attcggtaca aatgcagcct cccaacttct 1924081 agttagggct gatggcggaa tatctgacgg ttctctacac acatcagaca ttagaagatt 1924141 tcaatgtagc cttctgtacc atgaacgcga attcgttgcc catcttttat cagcttggca 1924201 gcattttcaa cgccaacaac tgcaggtaag ccatattcac gggctataac agctccatgg 1924261 gtcatcagcc ccccaacttc ggtgactagg ccttttatgg atacaaacaa tggtgtccag 1924321 cttggatcgg taaaggaggt aactaatata tctccatctt ctaaatccgc atcttccatg 1924381 tttaaaatga cacgcgctcg cccctctata actccggagg aaacaggtag acctacaatc 1924441 gctccggctg ggagattttc tcgtttatac tcacctgtaa cgatttcacc atcagacgtg 1924501 ataacacgtg gtggagatag tttttcatat aatgtgtact cgtcttttcg tgtactgatg 1924561 atttgataat ccagtttatg tgtgcgcacg acttcgtgaa gttcttcaaa agtgagatag 1924621 tatatatctt ctttttcatg aataacgccc gcttctatga gttgttcggc ttctttcagt 1924681 aaagcctgct tataaacgaa gtatcgatta accatgccgt attttggata ttccctaaac 1924741 ccgctgaaat tccggatgat atctatcgct cgttttgttt ctttggcttt ttgttcacca 1924801 tccggtaatt gcttcaatcg atctaataac tcttgttctt tcttcaaagc ttcctgtcgc 1924861 ccttgctcaa atttccgatg gccgacatta ggctcaaaat ttttaatatt attaagaatc 1924921 attgggacaa gtgtagttgg tttttcgctc catcgagttc ttgtgatatc aatctctccg 1924981 gtacatcgca ttccgtattt gctgagataa tcatagatcg cgtctcgggt tttgcttccg 1925041 ccatcaaact tagccagttc atccaaaaag ttatcatctt ttacatgttg taagtaatca 1925101 attacctctg gataaggacg aatcacatct gcgacgtcta atagcgcaag acccatttct 1925161 gaagtaatat tatggggtac agattgagaa agcgtatctg ctgcgttttt ttcacctaac 1925221 cactcgttca ttttttcgtt aatccataat gaagcattca tagcagttcg aattagaacc 1925281 gaactttttg ggttaaataa aatcttcttt aattcctgaa tatcttccag aataaaacga 1925341 aataaatctg atcctgattt cgtttggatg ttttgtttta actcttctat cgatgtttga 1925401 ctgctctcaa tcaaatcaga cacgattgtc ggatcgtttt caacttgagc cggcatatct 1925461 gcattgcctc tgctgggatt tggtgctgtt ttatcatttg gtatcgactt tatgaaatct 1925521 cgtcgcttta ttatggtcat aagtgcgtct tttaagagct gatcgtgctg ccccatgcct 1925581 tttaagaaaa cttctctgct gtcaggggat gccagatgat gtgtgacatc aacaaatagc 1925641 cttccaccgg ctttacgcat gggtgcaaca gtcgtcaaca gaaaaaaaga caatcccagt 1925701 ggttttatgg gatccgtcat catttgttga tgaccaacag aaatatagac gtgattttct 1925761 tggtcactcg cttcagggat ggggaataaa gtagtgattg gacgactctg tacaatataa 1925821 aaagtatcgc gggccaaaca ccattcgata tcttgcggct ggccgaaatg agcttcgatc 1925881 tgtcttccaa tgcgtgccag ctgtaaaatt tgttcatcag tcagtgtttg agccttttgc 1925941 tgatcagaat cgatctgctg tgtttctgtt ccgccttctt ttcgtccgta gatagccatt 1926001 tttttagttg ctattctctt atcgatgatt tgcccatcct gtactttaaa acaatcggca 1926061 gataccaagc cagaaaccag tgcttcacca agtccaaaac cggcatcgat ggataacacc 1926121 tttcggttgg aggtaatcgg atcagcggta aataaaatcc ccgaagcctg agggaaaacc 1926181 atcctttgaa cgataacgga taaatagact tggctgtggt caaatccatt ttgcatacgg 1926241 taaataaccg cgcgatccgt aaatagggac gcccagcatt tactgatatg ctgcaagatt 1926301 gcatcgacgc cggtaatatt taaataggtg tcttgttgac cggcaaaaga agcatgtggt 1926361 aaatcctcag cagtcgcact agaacgcacg gcataggcat gttcctcgcc aaactgggag 1926421 agatattgag ccactgcttt cacaacatcg gaaggaatgt ctacttccat aatgatttgc 1926481 cgaatcttcc ggctgatgtt accaatctga tctcggtcct caacttttag catggtcaat 1926541 tgatccaaca acacttgtaa cgtttcgttt tgttcgatgg ctttttgata tcctactgtt 1926601 gtgacacaaa atccttctgg tacttgtata ccttgaattt ttgataattc ccctaaatgt 1926661 aacccttttc ctccaacgag cgaaagctgt gttttttcaa tttcatgtaa accgagaacc 1926721 aaagaactca ttctacatct ccccttcaaa aaaaaatatt gacaagagct tcctagcagg 1926781 atataataaa attataagat ggatatctat aactttttaa ctagaaagcg cacgtagtgt 1926841 gattatatca ccgtgtctgt ttttgtgcaa tataaaaaga acctgggaaa tttcaccagg 1926901 ttcttttctt aatttccata gctagtcgca ttaaaaaact tggtttgagc tgattcaatc 1926961 ctctaaggaa atcctaaagt tgggttcttt ttgaacttac ttgctttgtt cgtagagtcc 1927021 ccattcataa attggacttt ttgttcttaa cagtcccacc tttaactagt ataaagttat 1927081 gaggatctgg ttaactacta gatattttta ttttgaataa ggcttatgtt tgataaagaa 1927141 gggttatgta aaggtgtctg ttgtgagcaa gcgctgacta caaaaaattg atagcattct 1927201 catttaaata ccattctatt aacctatagg gaaagtttta aaaccagatg gagaataccc 1927261 tacctccagc aattccaagg ccgttcacct agtagaaaac aacctttaac cattactaac 1927321 gattttaata atcattgatt ataaaacttc tcaaggaacg atcagcagcc cgttagctac 1927381 ccctgattaa ggatgatctg ttaccacact gttacgttag aacttccact actttgatat 1927441 ccttctgtcg ccatgacttg gtaagcccaa ttactgccca gattcattcc atggctcttc 1927501 catgcgttca catgattgct gaaagtgatt gtagcgttgc ttccggttgg tctcttcgac 1927561 tggcgaacac tccagtactg cgtaaaagta gtgcgatcgc catcaatgga aggtgcgtta 1927621 taacgtgtag ttgtatatat gtcatatgta cccccatcac tttttacagt acctttatac 1927681 gttccagtag gtctataagt accccatgaa tccactacat aatattctat gagaggtgat 1927741 ctcgtccaac catataaagt taaatatcca ttgccattcg gcgcccaaac tccggcatta 1927801 tagtttatcg tcctaaatgg cgaacctgta gtccaacctt taccaacaac aaaatttccg 1927861 gtattagacc aattaacact gtaattcccg ccagacccat tgacagcgtt tactataccg 1927921 cccccatcag tccaattttg ccagtagtct gtgctagctg cagaggcggt tgccgaaaac 1927981 aagctaatac tcattaaagc tgccgataat ccaactaaga aattcttttt aaacttaaac 1928041 atatgttacc tcctataata ttttttccga ctttgaggta gcactcgtat acatttaaaa 1928101 cattcttaat tactaacgcc aaagcttttg atcgtcccct tcagtataat accacgaatt 1928161 catgagcaaa tattaaaagt atttgtaatt caattacaaa tacctagaaa cacattataa 1928221 gtggtcttct tccaccatat cctgatcctt ttttcgcagg atcacaattc ttgtttctaa 1928281 ttcagatgga gtaatatctg caatgaattc ccattgaacc atttcaaata aaggagatat 1928341 acattagaga ttgtgaaatt attgtagctg ccgcttgtct aatgaaggga agcaaattta 1928401 tgaagaatat gaagaactga agaagaaaac aattaaggtt atactaagaa agaactgctc 1928461 aattaaaatt attgaccaaa tttgaggatg atagcttaga tcagttttac aaagaagttg 1928521 caagattttt atttgaaagg gctctgaaaa agaaaaaaaa gaattgacaa tcagggtaac 1928581 tgtgggatgt aaccgagcct ccaattcaaa ataaatatct ttaactttct ttttttattt 1928641 aaagagggac tgtatatccc tctttaaaat taagctttag attgctgctg aaagtaataa 1928701 aaattgtact tttgatcaaa cccttcttcg ctaccacaaa gaaaaataat gaattcaata 1928761 aatgcgataa tagaggggat accagtccag caaaacaaaa tatatagaat accttgtcct 1928821 actcttccca aataaaactt atgtattccc agacccccga agaaaaatgc taataatgcc 1928881 gctacaattt tgttcttctt gcttaccatg acttcctcct agttcattgc taccattttt 1928941 aaagtaatgc tttcacatta taatgcattt tccgccagaa atcgtgaaaa ttttgaaatt 1929001 cttttgagat tttttatttt attgagaaat gaaagctcat ataattgaac tagatggttt 1929061 tgggaggcat ttattcaaaa tgtattgcca aagattacgg caattacgaa aggcacacaa 1929121 attaacaatg gaacagttag ctgagaaaat tggaattgca aaatcaagtt acggcgggta 1929181 tgaagctgaa agcaaaaaac caccattgga caagttggtt attttagcta gactatatga 1929241 tgtttcagtt gattacatac ttggattaac agatgatcct gatcctaaag tggaaagaaa 1929301 aaatctaaaa gagtttttag aaaaaccaga tattcactgg gatggatata aacttacccc 1929361 tgagatatta gatcctatac ggaaaatttt gaagttggtt actgcaaaca acaattaaaa 1929421 aagccctcat aagggctttt gcataaaaca attatttcat tgaattttct ggactcattt 1929481 caagaagttt attcatgatg atagctaaac tttcaccagc tttttgtagc ttctcacctg 1929541 cttttatcag agtaattaaa gcacttaaaa agtccactaa gctattttga tttattgcaa 1929601 ctgtttcttt ataagctttg taagcttctt caaactgatc aaattgcaca cctttcatag 1929661 caacaacagc taatttatct gaaatatttc catatgactc tgttaaacta aaaaatcttt 1929721 tgacattgat tagtaaggca atgcacttta aataatcgtg ccccagacca atatgtaaat 1929781 tgcctgcagc aaacagcaaa tcgttcaaaa ctgtgtacgg ttcaccattc cttgcaactg 1929841 tctcaatccc tttgtataag tataataaaa agacaaatga atttttatct gtggaacgct 1929901 caggtaataa ggacactata ataacttact ttaagccaaa acatccaaat aaaaaggctg 1929961 gttataatta ttataaaaat caataggaac tataaatata taaagaggga ttgctatgcc 1930021 aaaattatat acatgtttaa tttgcggata taaaggatta attcaaaacc cattaaacaa 1930081 tgatggtgag tatcaaaaaa catttgatat ctgcccttgc tgtgattttg aatacggcta 1930141 cagtgaagat catgacgtaa gcttaggttt tattgtaact ccagattatt taattgacgc 1930201 tgcaattcag ttataccgaa aacagtggat tgagaatgga atgaaaactg caaatcctga 1930261 agatattcca gaagaattaa gaaacggtga ctgcttaaaa ttcgaggtgt tgttaaagca 1930321 attgaatagc ctaaatctcg atactgaaaa ctttgaaatc aagggattta atggttatta 1930381 agcagatcca agcccccata tgggggcgtt cttattattg tacagtctat cagaactatt 1930441 tatagaaaaa ctatttaatg tattgtataa atatcactga ccttttcttt ctccattcaa 1930501 cttccttaac cctcaactgt ttgctgctgc atcacattcc tcctttttga tttttgtgta 1930561 tcaagcctgt acaatattca aaaaccctaa aggatgatga acatgtgtgg caagttcact 1930621 ttattttctg agtttgatga catcattgag caattcaaca tagatcaatt cttacctgaa 1930681 ggtgaatatc accctagcta taatgtcgct ccttcacaaa acatcctgac aattatcaac 1930741 gatggatcta ataaccgtct gggtaaactt agatggggtc ttatccctcc ttgtgctaaa 1930801 gacgaaaaga tcggttataa aatgattaat gctcgtgctg aaacattggc cgagaaaccc 1930861 agctttcgaa agccgctcgg aagcaaacgt tgtatcatac cggctgacag tttttatgaa 1930921 tggaaacgcc ttgatccaaa gactaagatt cctatgcgga ttaaacttaa atcgtcgaat 1930981 ctctttgctt ttgccggctt atatgaaaag tggaacacgc tagaaggcaa tctgttgtac 1931041 acttgcacaa tcatcacaat aaagcctagt gagcttatgg aagacattca tgatcggatg 1931101 ccagttatcc taactgatga gaacaaaaag gaatggctaa atcctaaaaa tactgatcct 1931161 gattatctac aaagcttgtt gctgccttat gatgctgatg acatggaagc atatcaggta 1931221 tcttcattag tgaattcacc tgagctcatt gaatcccatt aagtaccact gccatatcgc 1931281 tttatatacc acctcctctt agctaatatg ttctaagtag gaggtggtat tttgtttgta 1931341 tctccaatgc tattgcattc aataaaagag ccttttgatg acgagagcta tatcactgag 1931401 cttaaattat caagactaaa attaaaataa gggctcatac atagttgata tatataatat 1931461 gtattgagac ctttattgaa caaacgcccc gtttgttaaa gtggaaatct ctataattaa 1931521 tagccgactt ttaaaagttc caatctaaaa ttatcctcta aatcggctag cttcattaac 1931581 ttctccgata tacctttcca atctttattt acagacatag aatgacatat cccaaacacc 1931641 ttagcctgtt cagtcttcaa cactgataaa tgtgaatgcc tatctttaaa atacattgca 1931701 taatcgttgg cccttcttgc acttaattgg aaaaggaaga atgttgtatg ccttatagta 1931761 tcagctgtaa taggggcatt taataattga tcagcataaa aacaaattgc ttcccttcca 1931821 attaacccta tatccacttt ttcgaatttc cgataagttc tcttaaaata atcaattgct 1931881 ctctcgtata tttcgttatt gtctaatgtg acaacctttt ttgctgtaga ccaatattta 1931941 ttgattcctt tcctatacgg aatcctttcc gccatccaag ccttcttaaa ttggtccagt 1932001 gataatggaa caaatggaaa gcctgctgga tcttgcacat aaatattttc attatccatt 1932061 tggtacccta gaacataatg gtcagaacca tttaaatttt tatgattcgg atggtatgtt 1932121 agctccccca tatctaaagg gcctagaatg acagggtttt gtttgatttg ctgttttaat 1932181 aacggaaatg ggtcatctaa gtcactagct tgctgatgtt cttctgcagt aaatccaagg 1932241 atgtttaaag cataattgat accatcatca ggatctctca tactaaaata aaggtttttt 1932301 tcatattcta tcatggcacc taacccaaca ccagttaata tctctacaag ttgaggagat 1932361 acattttctc ctattgatga aagaaacatt gcagttgaat ttgaataaca gtaatggcca 1932421 tttcctatat acactaacat cacctccggg tagataagtt aaccttacaa ttttgaaaat 1932481 tgaaaatcca tattaaattg ctccgttctc gtattcatca tctggatcat ttttatcaac 1932541 aataatgatc ttctcgccaa tctccgtttt acgatcgacc tctacgtatt cgcgcttgat 1932601 gctgctaagt gtttcgtcag ccagtacgtg aatcattaca gttgagttcg ctttaatttc 1932661 cgtcatttac tgcacccttt atattttttt tatgtttttt caattctttt tagattttca 1932721 tattggattt cactctttta attatagagg cgtgtcatac acatgccatc taagagagat 1932781 aggacaattt tgtcttggag gtgaaagcta atgaattttc ttcttgatct ttttacaaat 1932841 tggacttttg ataaagtcct ggattataca ctagctgctg taatttggtc tgtatttaaa 1932901 tccagatcaa agcagaataa gtatccaggc tatttcgaga aaatacgccg ctatagaaat 1932961 ttacatcccc ttctgcgatc gttatcgatg cgtgtacttt tatcgataac gatccatcct 1933021 tatatgttta gttaaaaact atcttttatt tagacttaat gggataaaat cttcattgta 1933081 aaactcttcc cactcagcaa ttaagtttct ataatagttt tggttagagt cggttggcat 1933141 agattcaata ttgtcaaaac cattaatacc gacatctaat tctactgtca ctaatccttg 1933201 gtaaaacttc ttataattct ttttaattac tttgaaaaat tcaacatcaa agaagtcttc 1933261 atattcagtt gctccactcc aagaatcata agaggactta acacgataat taaaaagaac 1933321 caaaactaac tcatctttca catcttttga tatttgctcc attaattgat ttagtccttc 1933381 actggcatta aaatctacaa tgcttaatcg gaagtcaatc caagtaacag cttcatcttt 1933441 taaccttcct tctccgtctt cattcacttc aattaataca tatctgtcag ccataattcc 1933501 ctcctaattt atttgtttaa aatcacgatt ttaactattt atgatccatt agtcacttcc 1933561 aaagcaactt ccatttaact cataattaat atataaaatg taaatggagt tgatatattt 1933621 gaaccttcga aaaattttat tgagttctgc tttatcatta ggtatgctgg tatctgctgc 1933681 tcctgtcttg gcaacaagtt cttcgtctga agtgatagta aaaagtgatg aatatgatta 1933741 tgacaccata tatcagctta gccccctacc aaacttcaag ccttctattg aatacaatgg 1933801 atatacttat actctcacac gttattattt cgattactca attcagtttt atacggctat 1933861 ttatacaaaa gttgtttaaa cttataggga gcttttttag ctcctttttc acctttttaa 1933921 gcaagatatt tctttctatg cggtctttta tgtatgaaat caaatgcttt ccctaattcc 1933981 ttctcttctg ttaccgctga gtccatatct tatattgcat ctaaggttta gtcagtcgag 1934041 atcattgaat atatagtact ttactcagaa cattttgctt attaaggaca taataagtgt 1934101 tcgtattaat ttttcctgtt acgataacga tcaaaaacaa aataatttat ctcattttaa 1934161 gacagaagtt attctgcttt ttcaaaaaaa tattcttgat tttccctttt ttagatgcat 1934221 ccataaagca ttcgatcata accattatat gtaactgaaa tgcaggtata agagttatta 1934281 tatagggatt acactaccat tatctggggg tgtattaaca tccaaatact caaaagcaag 1934341 aacaaatgta cccatagcac ttccatttcc acaccctatc caaattttca ttttcctaat 1934401 tccacatcaa aatcaccctt tttcacatcg taatcactat cgtaaaagcc tatagtatca 1934461 acgtttttcc ttcttaaaat tttctttttt tataaatatc ttcccaaaac aaccactttc 1934521 ccctactccc gcttatgttt tacgatcgtt taccccctat ttactaatta aagtatcaaa 1934581 aattcttatg tttactgtct ttttagctca ttataaattt ttacgataag caattgcctt 1934641 tgcttttgga tatgacttga ctgtatttgg tgacgattta acagagaaat ttaatgctct 1934701 tctgactttt ttaactgcat tgggcattat tgttgatcca acaactcaag gtatttctga 1934761 tagtgaacaa gcaatggatt atgattcacc gagataaacc ccataccctt ctcttgattg 1934821 aggagggtat ttttttcgtt ttttcaaatg aaaaaattgc agaaaacttt acatcctttt 1934881 acaatttttt caatgactat gttatgattg ttttcgagag atttttgaaa ttttcagaaa 1934941 gaggggttta aatgagtaag atcgcttctg aagttgtcgc tactacactg aatgactggt 1935001 acattgctat aaaaaaacaa aaggttgatg aatcaataaa atattattca gagataaaga 1935061 aactttttga tgaaatggaa gaagatcaag aagttcttgc gtattatagt ctattagaag 1935121 aaagacataa aatgttgctg cattcttcac gaggagagcc tttacaaaag cacacctatt 1935181 ttactgaaga caatcaaaac ttcataacaa aaacaaatga taaattagaa tacaactttt 1935241 atttatttga agcaatgtac gaggcataca acaaaaacta tgatcgagca attaacctat 1935301 atggattagc tgagaaaaag cttgcagaaa ttccagatga aattgaagca gctgaatttt 1935361 actctaaagt ctcttactta tatactcttg ttaaacaaag cattgtggca caacattata 1935421 taaaaaatgc aatttcaata tataagcgac accctgatta taaatgcaaa ctagctacat 1935481 caacaatgat tgcagctgca aactatgctg atatgaaacg atttgaggaa gcagaacaat 1935541 attacttaga agcaattgat attgcaaaag aaacaaaaga tgaattttta aaagctcaat 1935601 tatttcacaa tcttagtatc gtttattctg attggaacaa acctgataaa tgcattgaat 1935661 ctcttgaaaa agcaatagga aatgaatctt ggttacattc gatttattat ataaattctt 1935721 tattcatgat gattaaagaa ctctttaaaa ttgacgaaaa aatgaaagcc attaattttt 1935781 acaataaagc acaggaaaga ctcatattaa tggagaataa agtatacgaa gccaaaatca 1935841 gcatcctgta taacctttat tgtggggaat taaaaaataa tttcaataat tgtattagta 1935901 atattgagtt tttaaaacag caaaatgaac ttgaaagtgt agatgaattg tcctacatag 1935961 ctgcaaaaag gtttgaatca ataggtgctt ttgaagaagc aacgagcttt ttcaatgcga 1936021 aaatttgggc tgaacagaaa atgaatcagg tggagggaat cttatgaaaa aacttgtgct 1936081 ttgcgtatct attttagctg tgattttaag tggagtagct ttaacgcaat tgagtacaga 1936141 ttcaccatct aacatccagg tagctgaaag gccagtcgga ggttaaaaaa ggttgattaa 1936201 ttaatttagc cctactcaaa catttgagtg ggcttttatt ttatgattta tgtccaccgg 1936261 tcagccctgc tctgtggagc gcagtacctg caaacgtaac tgagatactt ctcactgttt 1936321 tttgcccgag taaaacttat taaagaacat caagcaacac ttataaatat ccatcgtgat 1936381 atttgtggga aaatcaattg ttttggatcg atgaaaacca ccgccaagct catctttact 1936441 gtatccaatt cctagactta ttgttcgacc aactttatta tatgtacgtg cccttcttgc 1936501 gacttcctca caaatctcca agagcacagc tttaatctct tctctctttg tataatccct 1936561 aaacaaaatc tgactcttac caaaactaat ctgcccctgc atcaatggag ctcctatttc 1936621 agataaatca attccgtgag catgatagta caactggttt cccattattc cgaacttctt 1936681 ttcaagcagc tctaaaggaa atttagctaa ctgacctaca gttgatatac ccattcgatt 1936741 cagatttctt tccatcctcc ctcctatccc ccacatttta gacaaaggtc gaactttcca 1936801 gagtctattt ggcacatctt catatctcca acgtgcaata ccactctttg ttttcttact 1936861 ctccaggtca agtgcaagct tactaagcaa catattgtca ccaattccaa ctgtgcacat 1936921 caaaccaaat tctctccaca tgctgctttg gattgctttg gccatttctt caggattctc 1936981 ttttcctgca tctaaaaaag attaatcaat tgaatacgtg tggacacatt tttcaggaac 1937041 aaatctgtaa aacagctttg taatctcagt tgaaactctg atgaaaagct tcatttgtgg 1937101 atttacaatg tatattcttg gatcttcagg tatctcaaat agtctcgatc ctgttttgat 1937161 tccaaaatct tttttaagtg caggagatgc agctaacact acacttccct gtctatccgt 1937221 attccctaca acggcaagat aacatgttaa aggattaagc cccattgcta cagccgatac 1937281 agaagcataa aaggatttca tatcgacaca gagtatattc tcacgtggaa attgtgagta 1937341 atcagtcatt gtatataact cttatgatgt tattcatgtt gatataaact gtattgtcgt 1937401 tctggtcttt tacgtgaagc ttttgttgtt caaaattaat gtaatgtact ctgccggtaa 1937461 cattttcaac aaatcccttg ttaaagagtt tgaatttcaa ctctttatta aattccaatg 1937521 cctcagaaac gagaatatcc atctcatcaa tttgtttgtc atctaaagat ggcttttcaa 1937581 cttttgatcc atcaatcaaa tcttgtttaa gctgtattaa ttgttctagc atcattgatg 1937641 tccattgata gttcctcgat ccctaaacat atcgactcac tccttgattg atctaatatc 1937701 aacagaacaa acgttcctta ttcaatatag atcagaacaa aagttcgatg taaatgttgg 1937761 taataaaata taaaggtcaa taatgatatc cgtagtatta ataaaggaga gattcttttc 1937821 gacgagggag agtgtgatgg tgaatgaaga agaggttaat tggatttttg gtcttagttc 1937881 ctgctttgat tatgtggggt ataactttaa tcgaatcaaa caaaaagacc cctgtagaag 1937941 ttttagaaag tgcttgggat gaatttgggt tatttagttt tgaaattgga ataacagatc 1938001 cggcaattac aataggcatg gatcaaacca aaagtgaagc aaaactccgt gaatatttaa 1938061 aagataatct gtctagagaa gccaaggaaa aatataagat ttatatattc aaggatgata 1938121 ctgataagct ggagaaagag catcaagaat atttgaaaga aaataatctc aataagtaaa 1938181 acgcccagca attaaaactg gacgttaaaa aacattagtt attctttatt tttttttagt 1938241 attcacacgt aatctctctc tatcttcttt aaaagaggat atgtagtttt tagactctaa 1938301 tgcagtcacc aacgctttat tagttctatt atttgagatc tttattcgtc tgcctttttc 1938361 agcaatttca gagtaaggtt cccctatttt agttaaaaat tcagtaattg attcattatc 1938421 aatatgcttt atttgtccag ctagcaacga taacctagta tccaatgttg taggtgattc 1938481 aagcaaaaag gttagtagtt cattggtgat tttcaggtta tgctcattaa taaaataaat 1938541 tgtatcttta agaatatcat tatttccatc tgtcaaacag ttagaattta aatgttgtac 1938601 aaatatttct ttgttaaatt gagagagctc gttgctatct atgagttgct ttatatcatt 1938661 ggcatcaagg gaaaaatcac cttgtttatc aataaactcg tcagggtttc tcaaagcgag 1938721 ttggatatga agtgtatcaa aatttaattt taactcttta aaattttccg gtgttagaga 1938781 taacaaatca ttatcaatca ataattttgc tcttttttca ctaacatttc cgagcggaaa 1938841 gtaaatccaa ctttgaatac tagcaattaa cacttcgaat gtttcgtctg taatatcccg 1938901 actattaatg atttcttctg agatatcttc taaaatcgct tcgtcaaatt tatcatcaaa 1938961 cgcctctata ttatttttag agagctcttt tctattaaca ggattgttta agaaagctat 1939021 taagaaatca ggcatttttt tattgtattc tacataagaa gtaataacgt ttgaccagca 1939081 tgcaaccatt ttattttcac ggatcacaat tggccataac tctttaatca attcaccaat 1939141 atccgagatg gcaaaagttt ttttcatgat cattgcatgc tttactctct tatctaaatc 1939201 ctcccgattt aataactcca gaaaactttc ctctggttcc tcaatctcct cagtaagtaa 1939261 aactttttca acaaatatat caatattgtc atttacgtaa ttgataacag cctgctgatc 1939321 agagttttta actgcagcat acgttatatt gggagcatca tttaaaataa ctgataaagt 1939381 tttgatatta atttcgtata gatttcgttg aacaacaaag tcatatattg tttcagaatt 1939441 tagcaaatga tccaaacttt taaatttaac ttggagtttt aatagtagtt cttttatttt 1939501 ctcctcatca gatactaagc tgagaagatt taagtacttg gataatgtga aagacatgac 1939561 cgactcttta ttcattcgga taatatcagc tatatcagca tatgtaagta tatctgacaa 1939621 gtattcctct tttttctgtt gtgtataatt ggatctaagt tcaataaaac tccaaaaatc 1939681 atcccattta ctagatatcg attggataaa ggcagcttta tttattgccc tttctttaaa 1939741 accatctatg aatgtaacag attctttact tccatttgca agtcgctcaa ttatgctatc 1939801 ataataatta cggtattcag aatgatccat tatatagttt aagagatgaa aattaagtac 1939861 ctctatttgc ttaaattcag caccaactaa tttgctcatt attttaccga tattatccag 1939921 ctcaaagctg taaggcaatg actcgtggtt tttaatacta aatacaaatt taatatcgga 1939981 aagacttaaa ctttctggat agaagtaagt gatgtaatgg ttatacattt catcaatata 1940041 tccatgacgt agcaggtaaa caagtaattt tttctcgtaa agcttatcag aaaatacatc 1940101 ctttgaattc atttttgtaa ttaatacttg taaagattgc gctcttattt cttgcttttc 1940161 tctctctaat tccaatagtt ctttcttgaa tttttggatt tcatttttct ctatagcctt 1940221 gatggcatct tctctttcaa agtagttcgg tttccgacca aaaacagttg caatttcttt 1940281 aattgtcgct ggaccatttc tatttcttaa ataacaatag atagtatccg cattttttaa 1940341 cttctcaaaa aaccgatctt tattagatgt attgcctcta aatacctcgc catctatatt 1940401 aatatcataa ttagaattca aatttgatat ttctaattcg ctcaagtata taaaatttaa 1940461 ttcagcaatt gattttaaag actcaacttc tatattcgct aatttcctct ctaattgttg 1940521 tattttagca ttaattaatt ttatttgttc ctcaattata agttgttttt tttgaaagat 1940581 ttcatatacc aaccctttgt tatattgtaa tttagaaaaa tccacaggat aaatattttt 1940641 gtagattatc attgctaaca ttttgttagg atcaagatca attgcactta gtttttgttg 1940701 gtatataaca aattcattaa aaatattctt taatactctc atgtcatcaa tgtaaattgt 1940761 tacatcctct aagaaatgag tgtttatcaa atcagaatat ggtgaatgtt ttattttctt 1940821 tttaagtatg tctcctgaat tagatgcatt aataattggt attactggga taataaaatc 1940881 aaaaaatttt gtgcggtctc tagttaactt ttcagtgtct gcatctccaa aaatatcatc 1940941 ttttatcgca tatataaaaa caacacgtct atctatttgt tctgaattat ttataagttc 1941001 atttaattct cttaatcttt caaaaatacc tatattatta aagcgatcta agtcctcaaa 1941061 tattacaaca ttatacttgg aggcttcaaa aaaatataat atttcatcta aatatttatc 1941121 aaatatagaa gagttttctt cccctgtatt tttttctaac gttgtattag caattgtaac 1941181 cttattcaat tttaagttgg cacggacaaa atgataaatt cttttatatg cgagtagagg 1941241 atatactata aagaacagtg ctaataatat agtcagtcgt atttgttgct gatcttcagt 1941301 accgagactc cttgaaacta acgtctcagc atatattcct ttaagtgcat caggtttaaa 1941361 aaggtagatg ccaactataa taaatgcaaa aaagaaaatc aaatttataa ttatgctctt 1941421 agtccttata tgcttaattc ttttaaacct agaaaaggga atggttctat cgtgtacccg 1941481 gtatatcatt tgttgcaaga tgcttttctc taacttattc tccatatcat ccgtatctgt 1941541 gttgaatgta gctaaggata tatttaagaa actatattcc ctgctgtatt gtttttgaaa 1941601 ggtatttaat atgctacttt ttccagaccc gtagggacca gttagggcga tatttttcac 1941661 ttttttattt tctaaccccc aacttagtgc tttagaatat tttccatcag tgtcgacatc 1941721 attgctagga gaaagatctt caaaaaggct ttcttcctta acattaggtt cttttagtct 1941781 aatcagaagt ttctctaacc actgcacaaa tttttttttg atttccccca aaaaaaacaa 1941841 atcctttcta aactttcagg tgtaatacga attaataaaa ctggagcaaa gaactaaata 1941901 aatgagtatg tagcaatgac aaatcatttc tcttccatct aatatagtcc tttatcgcca 1941961 gttgaaattc actattaatt gtaacatgaa agggcattaa aagtttctga aaaaaagatg 1942021 atcaataaac aacacagcgc ccaattacag gactgtttca tatttaaatt gaatttttat 1942081 aagcattaat tgcttcattt cgcagcagca tattatcttt gttaaccatg cctaagttgt 1942141 aagctttttt gataatatct aatacctgag aatctaacgc cgaaagatta ccgcctggat 1942201 taaatcttga tttccaataa tctaaagaat tatttaggtc aagtgagctt tttttgttct 1942261 cgggtttaac tacttcattt ttctcaagtg tttcacagaa ttcactaaaa ccaatggatc 1942321 tactgggagc tgagttattt cccccgtatc cttctgtagc caagctgcaa aatgctaaga 1942381 attttggatc ataaataaga tcgcttcagt ttacatttac cactgataat cacaatcctc 1942441 tcaaagcttt ttataattgt agcacctttt ccatttttac acatattaaa tatcgacaat 1942501 cattcaaatg atttaataat tgaatacaaa aaagaacctg cattttgcaa gttcctttca 1942561 cgttgtcaat atattgtgaa tttttaacga caagggcatt tatgtatagt atgatatttc 1942621 ctgtacagta agttttgctc actcgaggga gtcttgctca tcccctaatg aaaggggtga 1942681 tgctatgtca acattccagg cattaatgct aatgcttgca atcgggtcgt ttataatcgc 1942741 cctattgacg tatatagaaa aaatagacct cccttgagcc tcagaacctg aagggatagg 1942801 cctacctaga accacatcga gcaagccctt tgatgggcaa ctttttgtac agagccgggg 1942861 tgttggtagc acctcggtct tttttatttt atgcatttct cattaaagaa atgcactgta 1942921 atgtattgta aaactgatta taacacattt tccgtgaaat gcattacaat aaacctcaag 1942981 agacttggaa agctttttta ttgtttcttg taacgttata atgatctaaa atagcgcaca 1943041 agcctttata catcttcatc atttcttact cttctagctc gtctttcaac attccaattc 1943101 ccaatctttc cccagacatt cttgttagtc catttcccta gcttagtttt atcaaaccat 1943161 tcctgaaaca aagatatttc atctttcctt tgcattgtat cttttaaaag gaaataatgt 1943221 attatccaaa agatataaag agctgaacaa gaaagtccaa aaataagttt atttacctct 1943281 aaccaatttc ctaaaacttg ttcgcctaaa tatttatcat atagaagggg tataaaagca 1943341 aatgctgaag caccgacaaa aaaagctaga gtttctttaa accatctaac aaaaacaaaa 1943401 acagcgctta aaatataatt cgttctaaaa agaactttat accaattata attcttgttt 1943461 agagtaacaa atatacttct atattcttta ttaactgctt gatctaacat tctcatttta 1943521 taaaataatt ttttcctatt ctcgctgttc ttgtttaaaa tatactctct gaaacaatct 1943581 tctgtattca aaatttgatc tatcaataag atgtttctaa gttttgatag cttccccttt 1943641 ttcccactat attcttcgaa aaatttttct ataaggacca ttttatggtt ttcatcttct 1943701 tcattcttta tttcttttag ggaataatac ataggctcta aaattttttc taatgtttca 1943761 cctgattgag agtagaatcg ttctatactt ttttgtcttt gattgaatag caatgcaact 1943821 atacccgtaa ttactgcagt aagaatacca ttttgttgta tccaattcca aatatctaat 1943881 aactccaatt aagcttctcc ccttctctct gaatttactt ttaatacggg ctaaaataaa 1943941 aaaggtttca tataaaacgg gactagaaaa cttctgtcac tttaattatt taatccaata 1944001 aaataagctc tcattgcgag agcttatttt atttagattg aggatgtgca actcaagcct 1944061 tctattgcgc tatagcaata cttttgctta atcgtcccag tcttcatcct catcccagtc 1944121 atctttcgct tcctgaatct tattataaaa aaattcaata aagctgtctg caacagtatc 1944181 ttgataacca attaccctat cccattcaac tacagggcat tctccgtctt tcattttatt 1944241 tgtatctaga cagtaagcaa agtaatcaac atcttcaata accacaagtc catcagtaag 1944301 gccatagtgt tctttatatt cattagttct atttacaact gatgcatgat caaagttgta 1944361 gcctaaaacc aaaacgccga ataaaccacc agcaccgtat ttttctaaaa accatttata 1944421 actgttgggg agatcgcatt ggaggttttc ttcaatgcga ccaatgtttt catgacttgc 1944481 accttctgta aatatagcat tttgtttatt ttcattaata aagttctcaa ccttcgaata 1944541 aatcatataa acacctcaat tctcattttc aaattgtttc gctctccatt tccaatatct 1944601 ctttctaaag ctctcgtatt gtgcttttaa aaccttatca tttctaaaac tttcaccatc 1944661 agacttaagc tgatgaatga catcactata ttttgtatgt aagctgttcg ggatttcaag 1944721 cattgggcca ggttcttctt gaatcaagtg atgtaaatta atctgtgtac cgtcttttgc 1944781 ataaggggca ttcccgtttt tcattagctg aagatttgta acaccgaatt ctgttttttg 1944841 attaatatca atatctttca tagtatacac tctacggctt acatctttaa ctttcccctt 1944901 cgcctttacc ttcccctcta tttcatatgc atcatacttt tctttattta gccaaggagg 1944961 gcttttcttt tggccagtaa acggttttct tgttccatcc ggtattttct tcgcattagt 1945021 caaaagttca ttcttaaggt tttggctatc aaccacattg tatggcacgt tatctgctag 1945081 agcaagctta tacttagggt tgtaaggcag caaatctgga atcttaacgt ccttgatttt 1945141 cttacctgct tgacttgctt tatttattac cttgcccgct gcatctgctt tgttaatggc 1945201 tcctgcacct tttgtaccaa caacagctac agccactgaa ccaatagcat aggtaaccca 1945261 tcttgatcta gaataggcat ctccattcac catatccttt tgatatgact cttctattgc 1945321 tgctgaaatg gcatcgtatg ttttcactgg atgcatagct gcattaccca gtgctgagag 1945381 tgtttctcct ggatcggtga tgaagtccca tatgccggtt acagtgtctt ttcctacatc 1945441 gtataaacca actcctacac cttttacgat atcccaggtg atttctcctg ctccttctag 1945501 ctgcttcgct tgttcaattt gcactgcaag ctgcacttga gttggctcca gattctcgta 1945561 ccctactttc ttagcaatct ctaaatattc atcagggtca gatacaccgt cattaagttt 1945621 tttctttaat tccttgattt cacgttcctt tgcttcttct ttcttcacac ttaagtaagc 1945681 ttcagaatgc ttttcaatat cgcctttttt cttatgtatg tcactttctc tgtacgcttt 1945741 agcgttatag tgaattggtg tagcgttttt tcctttgcct gttgattcct gcagcttttt 1945801 aaagtcttgc tgaataaatt gttcgtttgg ttctgtttca gcgtattctg tttttaaatc 1945861 ctcatcaagc ttgtttagct tatcgattgt tttttcacgt ttgtcatctg cagaagaaag 1945921 tttgtctttg aagtcttctg ttgagaatat ttcaagggga aggatatcat tgatgttgtt 1945981 taatatgtct ttcattgctt ttttctgttc agacataatg gattttgatt ttgcataagc 1946041 gttagccaac tcgtgttcta gaaaggattc ttctatgtaa gcatcagaca tcttcgcatc 1946101 ttcaagtgtt gcagacatgc tgcttaagaa agcaatcttc atatcgataa gatcaatcca 1946161 ttggtctgtt acgccgacat gaccatgata aaatgcttta atgttgtcag cacccttgcc 1946221 tgaaaattca ctgtcatcta ggttagctac ttccttaaac gcttttttga gcttcaccat 1946281 ttgcgacctt agttccttat actctttggt tcttttatcc gcttcaaaga gtaatgaatc 1946341 agcctcaaat accttcatat cattctcctt cctagactac ttctatgtaa attttaccac 1946401 agtaatctaa ttgaataaca gaaaaagaca gccaaaatga ctgtcttata catcacacac 1946461 tatcttgttc tataataatt ttctgcggta tagtagcgcc aatcccaaaa aggttcccca 1946521 ttggccaata tataccggtc taaaaatttt tcaaagttta aatttaatgg attatattct 1946581 aaaccacttt caaatatata gagatagttg ggatcacctt ggttcacttt atctttatcg 1946641 atcattaaat ggcattcttc caataagtag ccaattggaa taccattgat atcttcaaac 1946701 aaatcttcat attttaactc ctcttcaatc tcttcaaggc taaatagctg aagtcctcca 1946761 cctatattct ccccatcaga aagaatctca aaaattttcg caccgttatg tagtgtcatg 1946821 aacttctgat aatcctgtgg aagggtaagc tggtgtttag cctcaaagct ttgaatgtca 1946881 ttcagggttg ctttgtcctg tgaaaaagta acaaggaact ccatgatatc accttctgaa 1946941 caaaacaatt taatggctcc tttttcgtct aaaagacttt tcaagccatt tacagtctta 1947001 tgaacaaagt tagtcacata catcacccct ttatttcctt ttaacaataa cctttcaaat 1947061 tccaaaagat gtgaacagat cgtgataggt gctcttttca gtgaatataa tgcaataaat 1947121 tctaaaaaga ggtgcctcca aaaattgaat tctctaatga atgatgacat ggtaaagatc 1947181 attagaaatg gccttagcgc atcgcagcat ccaaagcaca ttcttgttat aggagctgga 1947241 ttgtccgggc ttgtatcagc atctttgttg aaaaatgccg gtcacagagt aacgattctc 1947301 gaagcgagcg gcagagcggg cggccgtgtc tgcactttga gatctccctt tagtgatgat 1947361 ttgtatttca acgctggccc gatgcgcata ccgaataacc attcgttaac cttagaatat 1947421 atcaaaaaat tcaaattgcc aacaaatgta tttatcaaca gaaccccgat ggacatcatt 1947481 tatgcaaatg gaatcaaaac acgtctccaa gtttttgaac gagctcctgg aatattgaga 1947541 tatccagttg caccaaatga acaagggaaa acgtctgaag agctgatgct ttctttactg 1947601 cagcctattc taaattttat caatcaaaat ccagcaagaa attggcggat tgtcgaagaa 1947661 caatacaaaa atcattcgtt aagctctttt ttaaacacgt atttttcata tggcgcgatc 1947721 gatatgatcg gtgtactttt ggatatggaa gcgtatatgg ggatgtccct tgttgaagta 1947781 ttgcgggaat ctatcttttt ttcatccccc gctcacttct atgagataac tggcggtatg 1947841 gatctgctgc ctcacgcgtt tcttcctcaa ttaaaaacaa acattctata ccatcaaaaa 1947901 atgatgaaaa tgtctcaggg tgaaaatcgt gttacgatcc attgtcagca tcaacaaacg 1947961 gcagaattca catcattcac agctgatctc gctattgtaa ccattccttt ttcaacattg 1948021 cgatttgtaa aagtcgaacc ataccattca ttctcttact ataaacggag ggccatccgt 1948081 gagctaaact atatcagtgc aacaaaaatc ggcatagagt ttaaaagccg attttgggaa 1948141 aaagccggtc agcacggcgg caaatctatt actgatcttc cgattcgttt ttcatattat 1948201 ccaagcagaa atattggagc aaatggacat gctgtcattc tggccagcta tacatgggcc 1948261 gatgaggcac tgatatggga cagtctttca gaaggagagc gaatccagta tactttactg 1948321 aatttatctg aaatctatgg tgatattgtg tggtctgaat ttgtgtctgg cacttctttt 1948381 agctggagcc agtacccgta ttctgcggga ggttttacag ctttcgaacc aggacaagaa 1948441 ttagagctgt atccctatat tcctgtccct gagggcagag ttcatttcgc cggagaacac 1948501 gcctcactca ctcatgcgtg gatgcaaggc gcgattgaat ctggaatacg tgttgcttat 1948561 gaggtcaatc gcttacctta gatcatgctc acatcttgtt aaaactggtt gatataaaaa 1948621 gaagtgaaga atttatactc ctttgtttaa aagattaatt caaatatggg atgtctcaac 1948681 attcggttct ttattatctt tatacacgtt ttgaatgcgg acctcccttt tcttccataa 1948741 tcattaataa atacccaacc ataggaaacg ttttaattaa ccatcgggcg aactttcttt 1948801 cactgtataa cgattcttaa tgttgctttt tatcctttac ttgtcctctc tttttttcat 1948861 tgacttacat ttcttgaaaa ccagtataaa tcctaaagga attttgtaac aaatacagaa 1948921 ttggaaagag aagcgccaaa agaaatgcta actccttatc tcaaagacaa aactgcgctt 1948981 atattaaaag aaagaggtgt ctttagaatg gttcatttta aaaactgccc tgatccttct 1949041 ctaaacgcca attctcagtc tcaccccgaa ttttcatccg aattagaaca tattaagaca 1949101 agaatgcaaa actttattaa gcactcggtt acagaccaaa atatcgaagt tactgacgca 1949161 agggtgacgg ccgaaggaga ggtcacctct cttttaaaag aacgtctcga caaggaatat 1949221 tataggcttt tatctaaaat cacccgggaa gtaaatgtgg ctgacttcgg cgctgttcca 1949281 gatggaagag acaatactga agcttttcga aaagcaatcg ggaatggccg agtcaaagta 1949341 catgttccag cgggagaata cctcgttcaa gggattaaac ttccatcttg gacaacaatt 1949401 gttggacaag gtaaagggat cacagtgatt aaattgcatg aagacactcc agcgcatgaa 1949461 tgggtgatta caaatgatga ttatcaaaat ggaaatcgca atatttttgt ccaaggaatg 1949521 tcattagact ggaatccaag tagacaatgc ggtgtgagaa atccaggggg acagttctcc 1949581 agttgtttaa cttttgctaa ggttgaatat gggtggatca aagatgtgga agcgattaac 1949641 gcaggtcttc atggtattga tattacatcg ccaacgtatg accatttgcc tgataccgat 1949701 tggacaaaag acggatcaag atatatttgg atcgataact gtgtgacata tggttcagga 1949761 gacgacggca ttaccaccca ttatagcgaa tacatcttta tttcaaactg ccattcagga 1949821 aatccgcggg gaacagaatt tgctgaaggt gtttcaaact ccaacggaat agaaattgac 1949881 gacggctcta ggcatgtgtg gcttttgaat aactttacaa gcggcaacat ccgcggagtt 1949941 gaagtaaaag cccatgaact gtggccagcc tctcaaaacg tccatatcat aggccatatt 1950001 tcttatcgcg atgttcgtgc atttgatctt cgtcatattg gtcaccatca aattacagat 1950061 cctgaaagca caacagcata cgatgtcaca ctcattgatt gttcagcagt tgaaccagtt 1950121 ttcaactcgc tttacgatgc tgtgacccca agagcgctgg ttatttcggc atataaaaac 1950181 gttaatgtaa gcggattcac agcgattggt gatccagact atgattataa agaaaaccct 1950241 gtcgtagcct tgcaatatcg cagccaaaat ataaccatta atggtattaa aattcgcggt 1950301 tttaaaaaag ccggtgttga tattaattta tcaggcggat caaataaaac tgattatatt 1950361 aaaatttcaa attttgatat ttataaatct gctccaaaag gaatttcaat cggtggaggc 1950421 ctctacaatg tcaatattct aaatggaacg atgattactg acaatgggac agttgcaatt 1950481 cagtccccca ataatcaggc cacaattctc ggtgtacaat cagaaggtta tagtgtggca 1950541 gcctcaatca aaggccaaac ataccaacaa gttccaatca atttgaaagg aggcatacag 1950601 cttgcaacga cctctggctt tgccgttaac caaacaagcg cagttatagc aggtaccggc 1950661 gacattacgg cccgcggaga aagaaatgcg gtcattagct cttctggagg ctccagtact 1950721 gaaggctctc gcgcattaat cgcttcttca aataacgcac atattagagg aaaccaagcg 1950781 tcaagaacaa tactgtcttc tgaaaatatt atacttgagg aaccatacac cgtggcagga 1950841 ggtcatcaat caataaagtg gcttcttgac tctgttcggg gaaacgggac gtttgccggt 1950901 gcaatcagtt cttctttagg tggatatgga gagtattttg agagttcaac tggacagtta 1950961 atccatactg gtacaatcgt gactttaaga ggtgaaaaaa ttgtgcccgc gaatgttgga 1951021 gattatatgc ttggcgttat ttcagaaact tcagctttca tttcaggagc ctccagtttc 1951081 gtctggcagg gccgttattt gacaaatgag ttcggcggat ttatttatga aacggtgact 1951141 gatgaggaaa gcggtgaact catacgtgtt cccaaacaaa atccagacta cgatacagcg 1951201 ctggaggcaa attatcattc acgggcagca agagacgaat ggcacgttgt agggttggtt 1951261 ggccaacatt atgtgcgtat tgacgaaact gtcaatcaag gagattatct tacggcacat 1951321 aatggaatag gaacaaaagc cactgaagga agctggaaag taatgaaaat aacctctgct 1951381 tacacatcag aaaaagggta tggtatcgct ctaaccgtca tcaaatagtg gatacgccga 1951441 ccagttcaat atatgtttat ccaaataatt agatctcttt tctaggttct ttattccttg 1951501 tatgttatta tcaattttca atatctacca aaatacccct aatatactat cgtaattaac 1951561 ttatattata atcaaaaaaa ttttgacagc tgttccttct cgttattcat gaaagttgct 1951621 attgaaatga gtaaatggat atcatattag acttctatag caaatacacc atatatatcc 1951681 tttaagtatt tacaaattga aaatgtttca tgaggcttat taaaagtatt gttcttttat 1951741 catctgtaag tcgatacaaa ctgcattaag atcacaccta aatctcactg agttttttct 1951801 tacaaataaa atgaaaaccc tttccattct aaattcattt caccgttact aaaagtaatc 1951861 cttgcattcc ttcgccctcc atgctatatt catatagcga tgagctgaat tgtgtaagcc 1951921 gatgtacatg cctttacggc acacacgaat gtggcgtgtg gtgcatcgcc tcaatacgca 1951981 aagacgtttg ccttaggcaa acgtcttttt ttgcgttatc cgatttttgt gccgtttggg 1952041 acaggctgat ccggctgcaa aaggacgacg tcgccctggc cgggtatgcc gccgaggacc 1952101 aagacttccg atttaaatcc ggcgatccgg cggggcggaa agttcacgac tgctatgact 1952161 tgcttgttga tgagaccttc cggcttgtaa cgcttcgtga tttgtgcgct cgattgtttt 1952221 atgccgattt cagtcccaaa atctatcaca agcttgattg ccggtactct tgcttcagga 1952281 aattcttccg cttttacaat tgttcccgtt ctgatatcca atttctcaaa gtcatcaata 1952341 actgccatat caataactcc tttttctcct attgtaaagg agatatacaa tattctttta 1952401 actaaagagc catcattttt tatccgaata taaggtgttt cgatacaggc ggggcggcat 1952461 tcctgtgctt ttcgtgaacc atcttgtaaa agaagaaagg ttttgaaagc ccagcgcctc 1952521 gctcacgacg gtaagagttt catttctctc catcagcatt ctttttgctt cctcaaggcg 1952581 aaggtcggca atatagttct gcggggactt ccctgtctgt tttttgaacc agcttgaata 1952641 gtaagctggg tgataatgct cgatttctgc cagcttctta atcgtcagcc gctcaaataa 1952701 atggctgtga atgtatgcaa ttgaggcata gctatgggat tgaagctttt cttttatgta 1952761 ttgtactagc atatgaagcg agttggctgt tccggccttt gcttcctctg tcagcaagta 1952821 cctgatcgaa gaccagaaag gatcgagggc agcttcaatt cctgatcctg cacgatactc 1952881 atcaattttc attgcatgaa gcggaacatc cagtacaaga cattcatttc ttccgataga 1952941 acggaagcga tgctcgcact gcggcggaat atataaaaaa tgatccggat ttaatttcac 1953001 ctggcgcccc tcagtctcaa gatcaatact cccttcaagc ggaaaaagaa attggctgta 1953061 cgcgtgctta tgtgaatgat atagccgtgt gtatgtccgt ttttcgcaaa ttatctcttg 1953121 aagcgagtcc attagcaaac cccttccttt ggtcatcttt taatccggta atggtgttcc 1953181 gatataggcg aaaagccgat ttttccatat aaagaaactg ccgccagatt ttctttcatc 1953241 acttgtaaaa acatgcgttc cgctccgttg ttttttgccc attcagtcaa caccctgatc 1953301 acttgggttc ctgccccttt tcctctgtgc tcctcagcta caacgatatt actaagtccg 1953361 ccataaccat caatgacaga aaccgtgcca agcgctgtca ggctttcttt gtcatacatc 1953421 ttgaaaaaag ttttacacgg cggcatgcgt tcgaatatgt gtttgtaacc tttgtgacgc 1953481 tcgggtgaaa acccttctaa ttgaataaat tcatctatcc aaacagatga tggctcttgt 1953541 tcccacttgt atgtaaatcg gctgttgtca tttgttcggc tcataattga ccggcacaac 1953601 gctgtcatct ggaagcactc gtctaccttt tcataacggc tgtctgccaa tgcgtcatca 1953661 agccctttcg gtgatgcgtt gctaatatga aaacaaacag gtaagcctaa actttgataa 1953721 aaaagttcgg cctctagctg aaaatcccct tcaggcatat ccgcagacgt ccatacgcta 1953781 tttgcccttt tggttacgcc aaaattcgct ctgagaagcc atttccctat gcttttttga 1953841 aaataagccg gccatgaagc tgccgctaat cgttcaatct tgcgaatgtc atccattgca 1953901 taatgcctct cccctatgta tactcccttg atattataca atattcagaa atataagaca 1953961 tccatttatt tgtttacata atatttttat tgtttattaa taatcctgac aaaaatgtcc 1954021 gaattgaaaa tgacaggctt tctaaaatgt cctcctcacg ttcaaatgct tcttttgcga 1954081 ttaaaacagt aaagccatgc agcagacttc tgagccccct tgtcgcatga atggcagtct 1954141 tttcacttgc atagccgttt tcaatgagca gcttcgtcac aagacagaca atttggtcag 1954201 agacgatttc cgtccgtttg tcgtgaacct taagaagagc cgcttcataa tatccgggat 1954261 tttcaattgc aaaatcaaca tatgcatgag ctaaagaaag catcgcggaa tctccctttc 1954321 gttcggttac ggagtccgcc atttgatcaa aaagctttgt cagtcctctg acagcaagtt 1954381 ctgctctgat cgcttgcagc ccgttgatat ggttatacaa tgacgggggg cgaacattca 1954441 tttttttaga aagtgcagca agtgagacac catttacccc ttcctgatcg gcaatctctg 1954501 ctgcagcgtc tacaatcatt ttttgggtca aacctattct cggtgacatg ctcatcatcc 1954561 tttctttgct ttttggatcg cctgtctcat ccgctctgaa ggtgatcgca ggaattttcc 1954621 atgtccgaca gcgagacagg aaggcgcctt atcggcgagc aattgtgcac ttttgatggc 1954681 ctcctcctta ttccatgtgg cgaaagcggg aaaaggaaac gcccatttta tctgacctga 1954741 tacagcgatt cctccgcgca actgaaacgc atctcctgct attaaagtgc cgtttcttgt 1954801 atcaagaaat gacatgctgc ccggtgtatg gcccggtgtt ggaatggcaa gcagagaacc 1954861 aattgtttca ccgcccgtca gcagttggtg aggctttgtt tgtatgtgtt tcggaatacc 1954921 tccttttata ggcgtctgcg gctcatcttg ccgcaaagat gtgtcacctt ggagcaagaa 1954981 tgaatcccgt tccgagatca tgacctttgc atgcggaaat gtttgtgcca atgtatccag 1955041 tgatccgaca tggtccccat gtgcatgagt cagtaaaata tgctgaagcg gttttccaag 1955101 ctgattcaca gcttgaataa tccctttata gctgcctggc agtgcggcat caataagggt 1955161 gacttcgttt tcttcctcta ctaaatagca attaaccgga aacaatgctg gaaaaaaagt 1955221 cagctgccaa accgtttggt actgagtaat tctcatcttt ttattcctcc taacaaaaac 1955281 taatggtgtt agttttatta ttaactaaca ccattagttt ttcaagagtt tattattttt 1955341 ttatcgctac ataaatgtta acttgtgctc gctgtggcac tgcggcattt tgatcataca 1955401 tctcaaagtc acctgtaaac gtgcgcagat gccgcttatc ccaagtccaa atttccttcc 1955461 acgtttcaag cacaatctct tcaataggac cgattctgga agtgaaaacg gcgtaagcgg 1955521 aagccggcaa atcaatattt tcatatggtc ccggaagaat gtcgtcgtat tcctgaaacg 1955581 ttccgactga aaacgtataa aacccattcg tctcttgttc ataattcgaa tataaggcaa 1955641 taatgctctt gtctttttca gcctgtgata aaagagcgct catatcctgc ttccataatt 1955701 gatcccacag tgccggaatc ctcctttctt ccgtcatttc cagtgcgttg cttgtccgtt 1955761 gtgatagtcc ggcaaatcgt ttcaggtcta agtgtgttat atgtgaaaag cccatacgat 1955821 ctcctccttt ttttaagatt atagacaaag aaacctgaca gcagtgtgtc aggtttcata 1955881 tattttttgc atgtgatgaa tggtttcttt tactttatcc cttatatgaa gaggctgcag 1955941 aacctcaata tcctttccga actggagcaa aaaaccgatc agccattgat cttctggaag 1956001 tgaaatcacc gcctggcaga tttcatcttc ctcacaacag tgaaggacat catatccgaa 1956061 ccattcacct atacgctgac gtgctgacgg ctgaacaaga ataaccaatt cagttaaacg 1956121 gtccttttgg taccaactct tatcccatgg caaagtgtcc agctgaatgt cttttctgat 1956181 aaatgtctga tgtaagatgg ccagatcttt catccggttc agtttaaaaa agcgaaaatc 1956241 atttcttacc aggcagtagg catataaata ccagtgcccc gccttgcaaa ccaatgtata 1956301 aggttcagtt tcccgaagta gtgtttcccc gcttgcgctt gtatatgtaa aagatatcgt 1956361 taacaaccga tcgatggcag cgctgatttt ctcgcgcagc gtcttttgat cctcagtatg 1956421 gccccaagcc gtcatgtcaa taaaccattt ttctgtttgg tgcttaaatg cttgagtaga 1956481 ttgctcaggt ataaggtgtt tgattttttg ataggctgtg ctgtgagaaa cgggttcata 1956541 catagatgaa acgctttgca aagcggaagc aattgcaaac aattcctcct ccttcagcca 1956601 ctctctttca agccgatacg tttccatgat gccaattccg cccccggaac cctgtgaggt 1956661 cacaatcgga ataccagccc tattgatcgt ctcaatatca cggtaaattg ttctgacaga 1956721 tacttcaaac agctcagcaa gctctgcagc ctgcacttgt tttttgctga tcaataacac 1956781 aaccatcgct aacaaacgtt ccagtttcat tctgcgcacc ttttcttctt gtattttcca 1956841 acaaaacaat cataacattt tgataaagct tgggcatatc tattatgcgg cggaatacac 1956901 ctcgcatatg ctatgaaaac aggggtttcc ccttcttttt tgtgttcagt atttatttca 1956961 gctactattt ccgaccggat aagcatacac ttctcaacgg aggggatttc acatcatgca 1957021 tcttacactt cagagcgttt atcctgccat aatcatcatc ttttttctgt ataaaaaaat 1957081 taaaaggtcc atcggatacc agccgctgaa gccccgctgg ctgttcaccc gtatcattct 1957141 tttctcgctg tttgcttttg gactttcaat cttcagcgcc attcaccctt ttttatatgg 1957201 atatctcatt ttgggcattc ttggcggatg gctccttgtc tttttcgcta agaaaaacat 1957261 ctcttttgaa aaacgcagag gaaagatcta ttttcggact catatttggg tagaggtgat 1957321 tctcttaact ttatttctat caagatttct gtatcgagtg acggagcttt atcttacctc 1957381 acctgatcta aaccgccttg gatcatacag tcagtcaatc ggaacggacc ctctgacaat 1957441 tggcgtctgt tttctgatag ccgtttatta tatcggtttt tcttctttta tcatcaagct 1957501 cagcagaaac gaacttgaac agcacgaata caataaagaa aaagacatcc ttgcccgcta 1957561 acagcgagtt aagcaaggat gtctttttca atcatgctgt gtatgatgga tcatttgctg 1957621 aagaacatct aaaacatgtt catcctccgg agagtaataa atcgatgttc cttctctgcg 1957681 cgatttgaca agccggagat tttttaaaaa tctaagctgg tgggacacag tggattgcag 1957741 taaattcagc ttttctgcaa ttccgtttac tgcatgctca ccttgggaca ataaatggag 1957801 aattctgatt cgggtaggat ctgaaagcgc tttgaatgtt tgcgcgacta gaaacagcgt 1957861 ctcctcgtcc agatcagcag ccgattgttc cgtttctcta aattcagtca tatgtatcac 1957921 ctttctttat tcatagtttt atcttataac aaatgcgctt gagtgcaaac cagcctgctt 1957981 gtattccatt tcaatctcat agtttaaatt tatgtttcaa atcaggtttt tacttggtct 1958041 gatataccct cttatgtcat aataaaaaag gtcatactgc tccaaacatt gagggtgaaa 1958101 cacagtgaag aaaaagagaa aaggctgttt cgctgctgcg ggttttatga tgatttttgt 1958161 ctttgtcatc gcctcttttt tattggtcct gctttttttc aaccgggatt taatcaaaaa 1958221 acttccgatc gatacgaaaa cgattgtttt ggaacgttta accgattaca aacccttggt 1958281 ggaagaagag cttgaaagcc aaggactctc taattataca tcactcatat taggcatgat 1958341 gtatcaggag tcaaaaggaa aaggcaatga tcccatgcag tcctctgaat ctctggggtt 1958401 aaaacgcaat gagataacag accctcaact cagtgttaaa caaggcatca agcaatttac 1958461 cctcatgtac aagaccggta aggaaaaagg cgtggatttg gataccatta ttcaaagcta 1958521 caacatgggg gcaggttaca ttgattttgt agctgaacat ggaggaacgc atactgagga 1958581 attggcaaaa caatactccg agcagcaagt caaaaaaaat cctgatctgt atacttgcgg 1958641 gggaaatgcg aaaaatttcc gctatccgta ttgctacggt gattatacgt atgcagaaaa 1958701 agtaaaagaa aaaacaaaaa ctgttgaaga atctttgcag gttgcaacac ttgaaaccat 1958761 ggaatccaag gctcatgaat aagagtctat caatttactg acaaaagccc aaaaatgaat 1958821 ttgggctttt gccatgttta cacgtaaaaa aagccatact gagtatggct tttaataata 1958881 cggtgaaatc atcaaatata caataacgcc tgtaaggctt acatacagcc atagaggcat 1958941 tgtccatctc gcaatttttt tatggcgctc cacctgcatg ctgaagcctc tgatcagcgt 1959001 aaacagcgca agcggcacaa taattgcaga aaggcagata tgtgtaatta aaataaagaa 1959061 ataaatcggg cgcataatac cttctccgcc atagagcgtg ttttccgcaa tcgagtggta 1959121 cgtcacatag caaatcaaaa atagtaatgt tgttgtgaac gcagccaaaa taaagcgttt 1959181 gtgagctttg atatttttct gtttaatcat aatcagcgcg gccaataaga agataaacgt 1959241 aaagctattg aatatcgcat tcagcattgg caaaatgtga atattcgcat ggctgaactg 1959301 atctaattta ggcataaaaa acagcactgc gattaaaccg ttaatcagaa ctgtcagcgt 1959361 aaggacaatc cccgtgtaat ttttcggttt attttctgtt tggttcattt ggtgacctct 1959421 cctaatttgt actggctatc caaatcgtat gcaaattcaa agaagatgtc aacggtttcg 1959481 attgcttcgt cagaaattag acacacttca aaggccggag gctattagcc ccggcctgtt 1959541 aggtttacgc ctcttttatc aaatgttcaa tgaccttatg ttcattttca ttcagcaggt 1959601 tcttttgaat tttcgaatga atgggtttat tcatatgctg atccaagata tcggccgttt 1959661 ctttatcccc ggcaataacc attcgttccc atcttttcgc ggcagctttt tgatcaaggc 1959721 tggcagccag ccgcttatac agtctcgatt ggttctctgt tacatgttcc ctcatccggt 1959781 tctcttcaaa tggtggcgct ttgtctacag cggaatggct attcttccaa gactcattga 1959841 tcatatcata ctcataacgc tccaccgcct caatttttcc taaaacagtt tcaataattt 1959901 tcacttcatg ctgctgagtt aaaataaacg ccgtacttgg gtatgtctgg cgcaaaccct 1959961 ttagctgatc caggacagct gtttcttccc agtaaaatct tgtatctaca gggacttgaa 1960021 gcttaatagg ttcccatatg ccgctgtcgg aaacaaaaaa cacgagactg cggggcatgt 1960081 cttttcccat tgcattcaag tattgattca ttttagccct gattccatcc agacactttt 1960141 cctcctctgg atcactagct gccaaatact cttttaatcg gctgaatcct gactttaggg 1960201 caatcttcca ttctcccccc tgctgctctg gatctctcat gtctgtattg agatacagag 1960261 agagaatttt atccggcggt tccaattgga catactgtaa tttgttaatc aatgaatcaa 1960321 tcgccattcc gattcctcct ttttcacagg ttagttttct ttttcctctc ttaaaaacga 1960381 tcaaacctga ctttccgcta atttctagta ataatggaat tgttgtttac aatacgcctc 1960441 tcttctaata caattggtaa ctgtgtttct aagctgtttt ttgaaaggag tttgatcttg 1960501 tttactgtta aagaaaaaaa tcgtcaagag cttgaggaag aactaaatga tttagaattt 1960561 caaatttatc gcatgcagga gaatatgaag gatttatcta aagatgccaa agtgcttggt 1960621 attgatcaat cgaaacatga tgagtggatg attgtttcct cgattgatga tggccaaaca 1960681 tgcaaaatta tgctaactga ttgtaaaacg gcataccgag gaaaaggctg tttttcactt 1960741 gtagcgtctt acaaggacga tgccattcat ataggggata taaaaggccc tccgaatcac 1960801 gggtttggct ccatttgcat gaaatattta aaagatattg caagagacca taatataccg 1960861 aaagtcaccg gagacatcgc caaacgggat tggaatcatg tagaccggct gattcacttt 1960921 tatgaaaaac atcacttcaa agtatgtatc gatcatgata cccaatccgg cagcattaag 1960981 tgggttgatt tgtaaaaaag tctggaagaa agagccaaga tatgctgtaa tggtataaaa 1961041 ccattgatgg agggttctat gtacgcctca aaactgaaaa agggagacga aatccggatc 1961101 gtgtctcccg cgaccagcat gtctatatta tcaaatgaag caaaaatcca agcaaaaacg 1961161 gcgttagaac gcttaggtta tcgggtaacc atcgctgaac acgcaaatga atgtaacgaa 1961221 tttgattcat cctctatcga gtcaagagtc catgatctgc acgctgcctt ttttgatcca 1961281 ggcgtcaaag cgattttaac gacactcgga gggtttaatt caaatcagct gctgcgttat 1961341 cttgattacg agaaaatcaa acgacatcca aaaattctgt gcggttattc cgatataacc 1961401 gctctttgca acgctattta tcaaaaaacg ggtcttgtta cgtattcagg tccccacttc 1961461 tcaacatttg caatgaaaaa aggactcgat tatacagagg agtattttct ttcttgctgc 1961521 gcttcagacg atccgtttga aattcacccc tcaagtgagt ggagcgatga tcgctggttt 1961581 ttggatcaag aaaacaggcg tttttatcct aataacggcc ctgttgtaat ccaagaaggt 1961641 tatgcggaag gtactttaat tggcggaaac ttatgcacgc ttaatttgct gcagggaacg 1961701 gagtattttc ccgaaacaga acatactatt ttattgattg aagatgatta tatgtcagac 1961761 atccatatgt ttgaccgcga tctgcaatca ctcatccacc tccccgcttt ttcacatgta 1961821 aaggcgattt tgatcggcag atttcagaaa gcatcaaacg tatcaataga tcttgtaaaa 1961881 gccatgatcg aaacaaaaaa agaattatcc ggcatcccga tcatcgcaaa tataaatgcc 1961941 ggacatacct cgccaattgc cacgttccct ataggaggaa catgcaggat tgaagctatt 1962001 tcgggtacat cacgaatatg gattgataaa cattaatcag cttgtaaatt tttttacaag 1962061 cttttttagc gcaatcggct atgcatgccg cacgagacat gacaaatgtc atataggagg 1962121 catgatgtgt gctactacaa aagacttctc tcattagcgt atactgaacc gagacacaca 1962181 atgagaggat acttactatg actgaacaaa ccattgcaca taaacaaaaa cagctgacaa 1962241 agcaagtcgc tgcatttgct cagcctgaaa caaaaaacag cctgattcag cttttaaaca 1962301 cgtttatccc attcttcggc ctatggtttc ttgcttatct cagcctcgat gtctcctatc 1962361 ttcttacgtt agcattaacg gtgattgccg caggttttct gacaagaatt tttatcatct 1962421 tccatgactg ctgccatcaa tcttttttca aacaaaaacg ctataaccac attctcggtt 1962481 ttctgacagg tgtcctgact ttattcccgt atcttcaatg gcagcacagc cattcgattc 1962541 atcatgcaac tagcagcaat ctggataaac gcggaacagg agacatctgg atgttaacag 1962601 taaacgaata taaagctgca tccagacgaa caaagcttgc atacagactt tatagaaacc 1962661 cgtttatcat gtttattctc ggaccgattt atgtttttct gatcacgaac cgttttaaca 1962721 aaaaaggcgc aagacgcaag gaacgtgtaa acacatacct tacgaatctg gcaattgtcg 1962781 cgttggctgc cgcttgctgt ctgatctttg gctggcaatc gtttttactg gtgcaaggcc 1962841 cgatatttct gatttcaggt tcaatcggtg tttggctgtt ttatgtgcag catacctttg 1962901 aagattctta ttttgaagcg gatgaaaact ggagctacgt tcaggctgct gttgaaggca 1962961 gctcatttta taaactcccg aaactgcttc aatggctaac aggcaatatt ggttaccacc 1963021 acgttcatca tttgagtcca aaggtgccta actataagct tgaagttgct catgaacatc 1963081 acgaaccatt aaaaaacgta ccgacaatca ccttaaaaac aagcctgcaa tcacttgcgt 1963141 tccgtctatg ggatgaagat aacaaacagt ttgtgtcatt tcgggctata aaacatatac 1963201 ctgtaagcct tccgcctgat tcaccagaaa aacagaagct gcggaagaat gcctgatgat 1963261 aaaggaggtc ttctaatata ctagaaggct tcctttttat tgttggaggg tgcattctgg 1963321 ctttcacaat gataaagtta caagtaagat gaaaagctga aaatgaggta agatcatgat 1963381 taaaaatcat tttacatttc aaaaactaaa cgggattacg ccctatatat ggacgatatt 1963441 tttcatcctc cccttctact ttatatggaa atcatcatct acatttgtta ttattgtcgg 1963501 catcattttg acgcttttat ttttttcggt atatcgattt gcttttgtct caaaaggctg 1963561 gaccatttat ttgtggggat ttttattaat tggcatttca accgcctcca ttactctgtt 1963621 cagttatatt tattttgctt tctttattgc ttattttatt ggaaacatta aggaacgcgt 1963681 cccttttcat attttatatt atgtccattt aataagcgcg gccgtcgcag ccaatttcag 1963741 tctcgtatta aaaaaggaat tctttctgac acaaattcct tttgtcgtta ttaccctcat 1963801 cagcgcaatt ttattgccct tcagtataaa aagccgcaag gagcgcgaac gacttgaaga 1963861 aaagctcgag gatgcaaatg aacggattgc agaactggta aaattagaag aacgtcagcg 1963921 aattgcccgc gatctccatg atacgcttgg gcaaaagctt tctcttattg gtttaaaaag 1963981 cgacttagca agaaaattga tatacaaaga tcccgaacaa gcagctcgtg aactgaaaag 1964041 tgttcagcaa acagcgcgaa cttctttaaa tgaagtaaga aaaatcgttt cctctatgaa 1964101 gggcatccgg ctcaaggatg aattgatcaa catcaaacaa attctcgaag cagctgacat 1964161 tatgtttatc tatgaagaag agaaatggcc cgagaatatc tcattgctga atgaaaacat 1964221 tttgagcatg tgcttaaagg aagctgtcac aaatgtcgtc aaacacagcc aggctaaaac 1964281 ttgccgagtt gacattcagc agctctggaa ggaagttgtg attacagtgt ctgacgatgg 1964341 aacattcaaa ggagaagaaa attccttttc aaaaggacat ggcttactcg ggatgagaga 1964401 acggcttgag tttgcaaacg gaagccttca catcgatacc gaaaacggga ccaagcttac 1964461 catggcaatt cctaataatt caaaataaac ataaaggatg gcttatatga ttagtatatt 1964521 tattgcagaa gatcagcaaa tgctgctggg cgctttagga tcacttctaa acctcgaaga 1964581 cgatatggaa gtcgtaggca aaggtacaac cggccaagat gctgttgatt ttgtcaaaaa 1964641 acgccagcct gatgtatgta ttatggacat tgaaatgccc ggaaaaacag ggcttgaagc 1964701 tgctgaggag ctaaaagata caggctgcaa aattatcatc ttaaccacct tcgccagacc 1964761 cggttacttt cagagagcta ttaaagctgg cgttaaaggc tatttgttaa aagacagtcc 1964821 gagtgaagag ctggccaacg ccatccgtag cgtcatgaac ggaaaacgca tctatgcacc 1964881 tgaactgatg gaggacttat acagcgaagc taaccctctt acagatagag aaaaagaagt 1964941 gctcgaactt gtggctgacg gtaaaaacac aaaagaaatc gctcaggaac tcagcatcaa 1965001 aagcgggacg gtgcggaatt atatctcaat gattctagaa aagcttgaag tgaaaaatcg 1965061 aattgaagcc attacccggt caaaagaaaa aggctggttt aaataaaaaa ggatcttggc 1965121 atctgccagg atcctttttg ttaacctgaa attcccgttt gagaacctcg tcgcaaccag 1965181 aattaaattg atccatatcc tcgctcctac gcccgctgaa cgattgtttg gttaacagcc 1965241 caataaaaga ctggattgaa tgatatccct gttaaaatgg tcggccattg cacatcagca 1965301 gaatttctga tattgattat attgtatttt cagtatgaca aagttgtgcc acttcgctcc 1965361 cgaagctgcc atgcccaact gcaagagcct aatatcacaa taaaaaaccg tctgaaatca 1965421 atccgattcc gtaaatggta tctgctacat ccaactgctt attatctgcc aaaaacacca 1965481 gctcgtttcg ctgatcaaag atagtaacaa ccagctataa atgtcatgat gccgaatgtc 1965541 tctgtaatgt ggaatcaatc ttttaacccg agagcccctg aatcgcacat aaagaaaaac 1965601 gggaccactt tcttttatca gcatatgata taaacagctc taagcagaac aaaaaaagac 1965661 acaagccaaa agcttatgtc ttttatcaca atctatatta ttagtttaag actttaacac 1965721 ttacagtttt gacgccccaa ttagaagcat cacttttact tggtacaaat acgtcgattt 1965781 tatttccttt aatagcgccg ccagtgtctg ctgctgttgc ttccccgtag ccttcaacat 1965841 agactttaga acctagcgga attacattag gatcaaccgc aataactttc gcgttcgggt 1965901 tcttatttaa gtcaatgcct gtagctgtaa cgccggaaat gccgccgtcg ttagcagtgt 1965961 aagcagtagc agtaactgtt agttcttttg aagcttcttg attatttgta tttgattgaa 1966021 cagccttctc ctctgtgtta acagaagttt ctgcctcagc ctttgtttct tgtttaggtt 1966081 gctgttgtac agcttcttgt ttaggttgct ctttttgcac agcctcttgt tttggcgcag 1966141 cttgaggtgc gtttgtttgc gcattctcag tagctgtgtt tgctgctgtt gcctgacctt 1966201 ttactgaaag agttgatcca gcatagatca tgtcagagct taagttattc caaactttca 1966261 ggttgttgac tgtcgtgccg aatttttgag caatcttaga aagcgtatct cccgctttaa 1966321 ttgtatattg cccagtcgtg gttgtttctt ctgaagaaat ggtcagtttt tctcctgcaa 1966381 tgattttatc agaagttaac ttgttccatt cttttaagtc ctttaggttc actccatttt 1966441 tctgagagat tccccagagc gtatcaccct tttgcaccgt aatttctttt gcagaagcgt 1966501 gagctccgaa tgcagttgtt gaaagtgcag caactgccac aaaggacata atcgtcttct 1966561 tcataagtaa atcctccctt gttagctttt tattggcggc taacaggtga tatcgtaaca 1966621 cacgtaaatg tcaaatcaat aacaaaaaga tatgatttag attacagttc ctttacatga 1966681 aggatttctc tctgatggaa agacttgctg aacccttgat ataataggct tcgcaggtct 1966741 ttttattttg aggcgaaaca gagaaaataa aatgtgtttt ttatagaaaa aaagattgtt 1966801 tttctgtttt tttagtctgt catccttgca taagcctgta tttcttgtaa aaaaagccgg 1966861 ccgtattttg ctcttttttg ttctccgact ccttttatag acaaaagttc atcatcattt 1966921 acgggctgtt ttcctgacat ttcttttaac gtttggtcag agaaaacaac aaatggcgga 1966981 acaccctgct cagccgcaat ttctttccga accatgcgca atcgttcaaa tagctcgtca 1967041 ttttcagtaa tcgctgccgc ttttaacgct tcttttctcg ctactgataa ttctcctttc 1967101 agcacattcc ttcctttact gctgacaaaa agagtcggaa acgttccgtc tgacatcctg 1967161 atgaagtcgt cagaaataag aaattcgata aaatcactga tttcgccaac ggattggtgt 1967221 tttaatatcc cgtatgttga aaggtcggaa aagccgtttt caagaacttt tttatttttg 1967281 gagccggcaa gcacctgggc aaccatcgtc ttgccaaacc gttctttcat gcgaatgata 1967341 caagataaga ccatttgcgc ctcccgcgtc acgtcatggg ccgctcttgt atcggtacag 1967401 tttccgcact gtccgcacgc atcaggctcc ttttctccga aatacataag gataaaacgc 1967461 tgcagacaat cttccgtatg acagtagtcg accatttgtc tcagcttttt taaatcctgc 1967521 ttttgtttct cttcatgttc tgattgctca attaagaagc gctgcaccat aatatcctgc 1967581 ggtgaaaaca ggagaacaca ttcactggca agaccgtccc gtccagctcg tcctgcctct 1967641 tgataatagc tttccatatc tttcgggatt tgtgcatgca gaacaaatct gatatttgat 1967701 ttatcaatac ccattccaaa agcagaggtt gccaccatca cttgaagctc atcattaaga 1967761 aatctttcct gctgctcttt tctcacatca tcagccaaac ctccatgata ccggcctgcc 1967821 ctgacctgat ttcgtttcaa tctctcatat atccgatcag cttcttttct ggtcgctgta 1967881 tagacaattc ctgcttcatg cctgttgttt tgcacatatt cgtctataaa ccgatcttta 1967941 ttttctcctt ttactacttt aaaggttaaa ttctctcggg aaaatccggt atataccgtg 1968001 ttttcttttt gaatatgcag ctgtttgcaa atatcatcat gaacctcggg tgtggctgtt 1968061 gctgttaacg ccatgatgac aggcttgtcg tgtaattcac ggaacaagat ttcaatattc 1968121 ctgtagcttg gcctgaaatc atggccccat tgagaaatac aatgcgcctc gtctattgcg 1968181 accaaaggaa catctatgcc ctgcaaaatc cggataaact ctatggacgt tagtcgctct 1968241 ggtgtaatgt aaaaaagctt ataagcccct tctttgagtc cgttcagcct ctcatatatt 1968301 tcctgattgg attgtgtgct gttaatgtag gcggcgttaa tccccgcttc ttctaacgca 1968361 tcaacttgat ccttcatcaa ggaaatcaac ggtgaaatga cgatcgtcgt cccttcaaac 1968421 attaatgccg gaatctgata gcaaatcgat ttgccgcctc ccgtcggcat aatgcaggcc 1968481 gtattttgcc tcgcttccgt caccaagcgg atcgcttcat cttggccgct ccgaaacttc 1968541 tcataaccaa aataatgagc cagaagggat tgggctctat gtaacataac gtgtaaacct 1968601 cgcttttcct tgaatttctc ccatcatatc ataaaaaagc ggccttcatt tctttcacac 1968661 aaaaatggaa tattcactat accaaacctt tttagataaa ataaaaagcc atttccgaaa 1968721 aggaaatggc tttcgctacg tcttgccgta tgcaagtaag aaagttttaa accaccactc 1968781 ctcaaagtgg gtgtttgcag aaacgttcct gtcgtcctct gcaatggagg catgacattc 1968841 cggcttcgat ataaaactcc ctattacagc ttaaaggtta aaacttaatt aacaatacgc 1968901 acaaagtagc ttctttaata tagtacacca tcaggcgctt ttaatcaaga ggtcagaaca 1968961 attgtttaga aaaacttttt ccagtgaata aaactgtttt ttctccaaaa tacctgacaa 1969021 ttcgacaaac aaaaaatata ttacaataaa aaaaatagcc tttattgcta aaagcgaatg 1969081 attattttct tctatattaa tgtgtatata caaaaagact cctatttgta acgataggag 1969141 tcttggcttt attagaattt tgcagcaaga tcttttgctt cttgtaaacc tttttcaacg 1969201 atttcttgcg cttgatcagg tgctgcgtta tgtccttcga tgacaactgt gtgcaagtct 1969261 tgaacacccc agaaaccaag aactgttttc atgaagttta atgacatttc aagtgcagcc 1969321 attggtcctt ctgagtagac accgccgcga gcgttaagaa gcgcaacttt tttgccgccc 1969381 attaaaccga ctggtccttc ttgtgtgtat ttgaatgtaa cgcctgcgcg agacagataa 1969441 tcaacataag tatgaagcac tgctggcact gtgaagttcc aaagcgggaa tgcgaaaaca 1969501 actttgtcag cttttacaaa ctggttcaga tatttgtcag caattgctgc ttgttttttc 1969561 tcatcttctg tcatttccat tccttgacct gctttaaatg ttccgttaat catatctctg 1969621 ccaaggtaag gaaggttttc cttatgaaga tctaattcaa ccacttcatc attagggttg 1969681 ttttctttat aagcagctaa gaaagcttcg taaagtttag ttgaaacgcc ttcttcagct 1969741 gtacggtcgc ttgattttac aaataaaact gtagacattt gtattcctcc cggtaaactt 1969801 tttatattta cttacaaata gtatgttact ttctttttta cgtaaagtca atcactttat 1969861 tttgaatatg agattttttt tcaaaaaaag caagtacatc taatatcggt gtacttgctt 1969921 ggcattttta cttcgaatct tgttcacgat ccaagatttc atacgtctgc gagctttttt 1969981 gatcaattgt ttctttgttg gataagtctt ttacctgttc atgaaactct ctttcataag 1970041 aaggagcatc tgtctccaga tcatcctcca catcagcttg ggcctcaact gtcattcttg 1970101 cataaggaac agcttcaagt ctttcgtaag gaatctcttg gccggttttt tcacacacgc 1970161 cataagttcc gtctttcatc ttttgtaatg cacggttgac ctcctctaac agctcccggt 1970221 caatctcttt cactgtttgg tctgtcatcc ggtctgtgac gagcgtcccg tggtctgcca 1970281 tatggttgtc aaccccattg gaaagctccc ccacttcttc cgtcattgat tctgtttcct 1970341 ttttctcgcc agacaattct ttttgcatat cgagcaattt atgatagaga tgctgtgttt 1970401 gttcttttgt cagtgccatg tatatcctct cctttctatc ctgtttcccg ttttgccttc 1970461 tgtcaaacat ggaaacatcg atggaaagat gagctactgc ctttttgaac ggatcgtgac 1970521 cgctggcgtc gatggtgctt cgggttttcg ttggcacttt ttgtccttct cttctggcgg 1970581 tatataatag gttgcgccta tatttaatct gccgctcagt tcatcaatgg tcagctcgcc 1970641 gaattcaaga tgatagtcaa ctttttcgac attcagcgtt tcaatatgta tataggtttc 1970701 ttcagactct tgtttgctgc tttgtttttg tttctcaatc actgagagtc tttcttcaca 1970761 ttcacgcagt ttgtcaagtt ctggtttcaa gcaatgcctg atcagcgacc ggaacatttt 1970821 tttcatgaca tcacgaccct ttgcatactc ctctttcgtc tacatatata atgaggtata 1970881 tcccatagaa aggagaggtt ttcatgcttc cgactaacat caatatttct catctcaaga 1970941 ctaactcgat aggcaccggc tcatccctta cctttggttc tgcggagtta aggaacaggt 1971001 gctctgctat caaaagaaat aacggttttg gggaacaaaa tgcagatggt attgttatgg 1971061 tcattccgat tgaatcaatt gatgaccgtg atgtgtcaga tgcactcagt atgaaaatca 1971121 atcatcaata acaatggttt tcgcttgacc ttcgtctttt tgaatagtga tgtataggat 1971181 tccgtcttta aaaatggcat tcatctttcc atgaagatga tcggaaagcg gaattttctt 1971241 ttcaaaactt ccgtatttcc cttctttttg gcgaaagtcc tgttcattaa aataggaaaa 1971301 gcgctgcccc ttcaccacta aataatctcc gtacgataat atgtgaacgt cttgtttacg 1971361 gtagcctgga agataaatta aaaactgcac ttccgcaacg gtatctacaa tatccatgct 1971421 cggaaatgaa gcatctcctt tccctcgctg atcttgctgc gcaaacggaa acggagattg 1971481 gccatttgtc ataaaagggg ttttttggtc ttcatcaaat acctgtttcc aaaagtcacc 1971541 gccgtacatc tgctgtgcga attccatcca ctgcttcatc ttttcgaaat ccatttgaag 1971601 ccccctgtct taacatactt tataaccgcc agcatacaac tatagaaagg aggtttgcct 1971661 gtggttcaac caactccgta tatcaatatt aatattttca tgctgaaaat taattccttt 1971721 gaaaatgctt cagcggttaa cgtaggacaa aatttattgg cagaatggca aaattcagat 1971781 aaaaaaaatc aaggctacgg acagaatttt ggagatgcga gcggatttat gggcacgaga 1971841 agccatgtgg atgacagaga ccaaattgat tctccggcct cttttgaaag tgaagcggtt 1971901 aactcctcaa tcaaaaggaa gtgatgagat gttcttttca ccctccgtcg taaatgtcgg 1971961 cggatttaaa atcaatacga tggatcgagg ttcctcttta acactcggtc cgtatcagca 1972021 ggtcgattac tttttatcag ctaaaataaa tcaagggttt ggagaagaaa atggcgactt 1972081 tactcctctt gtcgtgccga tttcaaatgt attagatgca gatcttgttg attcgaactc 1972141 agcgaaaaac agtgtggtgt aataagaaca gggcgcacat gccctgttct tgtttttata 1972201 tataaaaaaa gcctaaccat tttttgaacg gctggctcat caaatattca gctgcacaaa 1972261 tgctttgtca gcaccgcctg aacctcgctt aaatcggtgt ctttcgcaaa ttctaattcg 1972321 aaagttttgc ttcttgtcat caataaaagc ccagtgtccg gatcaaacat tcccgcttct 1972381 tggatggcaa agctttcaat tgttttatat ggaagaaata cacgaacctt ctttttagaa 1972441 aacattttat tgtcaaagaa aatgatccgc ttatttgtaa agcaaatttg gtccactcgg 1972501 agcttataaa tcgattcaat tctttcccct tcaacgagca aagcctcaag cttctttgcg 1972561 tccgttgatc tgctaacaga aaaaataccc aatgaagaac ccctctttct gcatttatct 1972621 atttgtttta tcattcacta cataaaaata agtcctttat ccctatataa gaatacgaca 1972681 tagaagacat ttaaaccatt acgaacagat tacatttttc aaatttttga tttgtttttt 1972741 ggcttttaag ctgttgtcat caagtaatac gcacatatag agaaaaaagt ttcaatattc 1972801 agcaatgttt ttataaaaaa gtggttttta atgatttttt taattttgtt ttatatttcc 1972861 tgttttaacc acaaaaaaac cgcagctgag ctgcggtttt atgtatcgac tgcttttaac 1972921 aaaatctgtt tgatgcttca aggaagcatt acatctcttc gaagtattct ttataatagc 1972981 cgccgacttt attcgtattg tcgaccacaa agagaaactc ctctgtttca ttttttactt 1973041 catattcttt tcccggcgtt aaaacgcggt ttacgatata tttttttgcg tttgtctgca 1973101 cacactttac ttttttaatg gtttcttttt caagccaatt tttatgaatc atgatgaaat 1973161 ctccttttct tatctataag cttattgtag cttttttctt ttgtaaattg caatatcggt 1973221 tattcattga ttttgccttg atttctatta tagaatgttt gtatacgctt acgtttgaag 1973281 caactatcac agcttatttc tgctattcaa tccaggaatc aatgtgctat caccaagaat 1973341 ctcagaacag accataaaaa atgactggag gtttgttacg gatgagttct ttaacgatgc 1973401 aagtgacgaa aaggctggag acatttttac agggaacaaa gaagctttat attgacggaa 1973461 agtttgttcc gagtgcctca ggggcaacct ttgacactcc aaacccggcg accggcgaaa 1973521 ccttgatgac gctgtatgaa gcccaggctg cggatgtgga caaagctgtt aaagctgccc 1973581 ggaaagcctt tgaccaaggt gaatggagaa caatgtctcc agcttcgaga agcagactga 1973641 tgtataagct ggcagactta atggaagagc ataaaactga gcttgctcag cttgaaacac 1973701 ttgataatgg gaaaccgatc aatgaaacga ctaatggaga tattccgctg gctattgagc 1973761 atatgcgcta ttacgccggc tggtgtacaa aaataacagg acagacgatt ccggtttccg 1973821 gcgcttattt taattatacg cgtcatgagc ctgtcggtgt cgtcggccag atcattccat 1973881 ggaatttccc gctcctgatg gcgatgtgga aaatgggcgc ggcacttgca acaggctgta 1973941 caatcgtcct caaaccggct gaacaaacac cgctttcagc tctttatttg gcagaattaa 1974001 ttgaccaagc cggtttccct gccggtgtaa tcaacatcat cccaggattc ggtgaagatg 1974061 cgggagaagc gctgacgaac cacgaagcgg ttgataaaat tgcctttacc ggttccactg 1974121 aaatcggaaa gaaaatcatg tccaccgcag cgaaaagcat taagcgtgtg acattggagc 1974181 tgggcggaaa atcgcctaat attcttctgc cggatgcgaa tttaaaaaaa gccatcccgg 1974241 gcgctttaaa cggtgtgatg tttaaccagg gccaagtctg ctgtgcgggc tcacgtgtct 1974301 tcattcataa agaccaatat gatgaagttg ttgatgaaat ggcatcctat gctgagtcac 1974361 tccgccaagg agcgggactt cataaagata ctcaaatcgg gcctctcgta agcaaggaac 1974421 agcatgagcg cgttctttcc tatattcaaa aaggaaaaga tgaaggagca aaagcagtga 1974481 ccggcggaag ctgtcctttt gaagcaggat attttgtcgc accgactgtg tttgcgaatg 1974541 ttgaagacga aatgaccatc gcaaaagaag aaattttcgg acccgtgctg actgcaattc 1974601 cgtacgaaac agtcgatgaa gttattgaac gggcaaacca ttcagaatat gggcttgcag 1974661 ccggactatg gacagagaac gtcaagcagg ctcactatat cgcggaccga cttcaagccg 1974721 gaaccgtttg ggtcaactgc tataatgtgt ttgacgcggc gtctccattt ggcggttata 1974781 aacagtcagg actcggacga gaaatgggat catatgcctt ggataattac acagaagtca 1974841 aaagtgtatg ggtaaacctt gaagactaac atgtatgttt aaaaaactgc tgcctgccag 1974901 cagttttttt ctttctgtaa tggcagtaaa agacgctgaa tatatatgct tctgaaggag 1974961 ttgagcgtga tgggcacact tcaggagaaa gtgaggcgtt ttcaaaagaa aaccattacc 1975021 gagttaagag acaggcaaaa tgctgatggt tcatggacat tttgctttga aggaccaatc 1975081 atgacaaatt ccttttttat tttgctcctt acctcactag atgaaggcga aaatgaaaaa 1975141 gaactgatat catcccttgc agccggcatt catgcaaaac agcagccaga cggcacattt 1975201 atcaactatc ccgatgaaac gcgcggaaat ctaacggcta ccgtccaagg atatgtcggg 1975261 atgctggctt caggatgttt tcacagaact gagccgcaca tgaagaaagc tgaacaattt 1975321 atcatctcac atggcggttt gagacatgtt cattttatga caaaatggat gcttgccgcg 1975381 aacgggcttt atccttggcc tgctttgtat ttaccattat cactcatggc gctcccccca 1975441 acattgccga ttcatttcta tcagttcagc tcatatgccc gtattcattt tgctcctatg 1975501 gctgtaacac tcaatcagcg atttgtcctt attaaccgca atatttcatc tcttcaccat 1975561 ctcgatccgc acatgacaaa aaatcctttc acttggcttc ggtctgatgc tttcgaagaa 1975621 agagatctca cgtctatttt gttacattgg aaacgcgttt ttcatgcacc atttgctttt 1975681 cagcagctgg gcctacagac agctaaaacg tatatgctgg accggattga aaaagatgga 1975741 acattataca gctatgcgag cgcaaccata tatatggttt acagccttct gtcacttggt 1975801 gtgtcacgct attctcctat tatcaggagg gcgattaccg gcattaaatc actggtgact 1975861 aaatgcaacg ggattcctta tctggaaaac tctacttcaa ctgtttggga tacagcttta 1975921 ataagctatg cccttcaaaa aaatggtgtg accgaaacgg atggctctgt tacaaaagca 1975981 gccgactttt tgctagaacg ccagcatacc aaaatagcag attggtctgt caaaaatcca 1976041 aattcagttc ctggcggctg ggggttttca aacattaata caaataaccc tgactgtgac 1976101 gacactacag ccgttttaaa ggcgattccc cgcaatcatt ctcctgcagc atgggagcgg 1976161 ggggtatctt ggcttttatc gatgcaaaac aatgacggcg gattttctgc tttcgaaaaa 1976221 aatgtgaacc atccactgat ccgccttctg ccgcttgaat ccgccgagga cgctgcagtt 1976281 gacccttcaa ccgccgacct caccggacgt gtactgcact ttttaggcga gaaagttggc 1976341 ttcacagaaa aacatcaaca tattcaacgc gcagtgaagt ggcttttcga acatcaggaa 1976401 caaaatgggt cttggtacgg cagatggggt gtttgctaca tttacggcac ttgggctgct 1976461 cttactggta tgcatgcatg cggggttgac cgaaagcatc ccggtataca aaaggctctg 1976521 cgttggctca aatccataca aaatgatgac ggaagctggg gagaatcctg caaaagcgcc 1976581 gaaatcaaaa catatgtacc gcttcataga ggaaccattg tacaaacggc ctgggcttta 1976641 gacgctttgc tcacatatga aaattccgaa catccgtctg ttgtgaaagg catgcaatac 1976701 cttaccgaca gcagttcgca tagcgccgat agcctcgcgt atccagcagg gatcggattg 1976761 ccgaagcaat tttatattcg ctatcacagt tatccatatg tattctcttt gctggctgtc 1976821 gggaagtatt tagattctat tgaaaaggag acagcaaatg aaacgtgaat cttatcaagc 1976881 ggagatgttc aattggtgtg aagccctgaa agatcagatt caaaagcgag gtcagcttga 1976941 ccagtttgaa gatcaaatcg acaagatgat tgaggctctg gaagatgacc aaacaacaga 1977001 agaagattgg tataaacagg ccgctgccct ttatcgggat attacagaat cagatgatac 1977061 aagtgaaaga cgcgcttatg tccctatagg gaaacacgtg ctgccaaagc ttccttacaa 1977121 atactccgcc ttagaacctt atatatcacg cgatattatg atccttcatc atacaaaaca 1977181 tcatcaaagc tatgtcgatg gcctgaacaa agcagaatca gagcttaaaa aagcgagagc 1977241 gacaaagaat tatgacttaa tcactcattg ggaaagagag cttgcgttcc atggagcagg 1977301 ccattatttg catagtattt tttggttttc tatgcatcca aacggaaaac ggcgtcctac 1977361 aggggcattg ttccaaatga tagacctttc atttggaagc tattccgctt ttaaagaaca 1977421 ttttacccag gcctctaaaa aagtggaagg cgtcggctgg gccattctgg tctgggcacc 1977481 tcgatcagga cggctggaga ttttaacggc agaaaaacac cagctcttta gccaatggga 1977541 tgtgatcccc cttttaccgc ttgacgtatg ggagcatgcc tactatttgc aatacaaaaa 1977601 tgaccgggcc agctatgtcg atcactggtg gaatgtcgtg gattggcgcg aggctgaaaa 1977661 acgttttgag caggcaaaag aagtcgtttg gaagctctat taaaaaaagc cccctttcct 1977721 cgggggcttc gtgtgttaaa aaatacctat cacatgcaaa aacacgatga tgatggcaac 1977781 aggagataga tatcgaatga gcagcagcca aaccgcaaac cactttcgtt tgagattgga 1977841 accgcttttc agctcgtcaa acaaatcctg tttcggtatt tttagcggaa caaaaatcga 1977901 aatcagtaac gcacctaacg gcattaaaat attgctcaca agatagtcag ccgcatcaaa 1977961 aatagacaga tgaaatatag tgacgtcact taagacaccg tatgataatg cagacggcac 1978021 accgacaata aaaatagcaa taccgcctaa ccaagcgaat cgttttctct tattgatatc 1978081 gcctttcgac agtactgcga ccaaaatttc cagcattgaa aaagcagatg tcaatgcagc 1978141 aaataaaaat agaagtaaaa atgctaataa aaagataatt ccgaacggca tttgattaaa 1978201 cacagtcggc agaacgttaa ataacagaac cgggccttgg tctggcttga ggccgaatga 1978261 aaatacagct ggaaaaatcg caattccggc cattacagca acaagcatgt tcataacagt 1978321 tacagataca gcggactgta ccagattttc ctgtttctct aaataagcgc tatacgttac 1978381 catgacagat acaccgacac ttaataagaa aaaggattgt cccattgcat ataaaatggt 1978441 attggcatca attgcagtta aatcaggcat gaggaaaaat ttgattcctt ccatcgcgcc 1978501 atcaagtgta accgaacgca ccattaaaat gatgaataat agaaaaagcg ccggcattaa 1978561 tacttggctt gctttttcaa ttccgctgct tacccctttt gcaacaacta aaattgttac 1978621 caccataaag agcagctggc ctcctacagc caaataagga tttgaaatgg tacttgcaaa 1978681 tatcgtatca aaaccagatg tttgcgataa accgccagtg aagcctttta taatataaat 1978741 taaaatccat ccgcctacga cactgtagaa agatagaaga ataaagcacg tcaccatgcc 1978801 taaataaccg atccaatgcc acttcgttcc tggagcaagt gttttatagg actgaacggc 1978861 atctttctgt gttcttctgc ctatgatgaa ttcacctaac aataaaggca gtccgattaa 1978921 aaccgtaaat aaaataaaaa taagtaaaaa tgcgcctcct ccgctggttc cggcaacata 1978981 tgggaatttc catatcgcac caagcccgat agctgatcct gccgcggcta aaataaagcc 1979041 gagcttcgaa gaccattgat ttgcttcctt caccgtatca ctcctatttg atctaaccat 1979101 tataaaggtt cattgtaaga atatcttcct atatagtcaa gaacatttta attagtttac 1979161 atcatatatc tatagacatc tgccaaaaac taatattgaa ttattcagaa aattatttat 1979221 aataagagaa tgttatgaaa tttgtaagaa tttctgctga agttcttgat aagtgtgtta 1979281 ggagtgtttt tatggacatc attagaaaaa taagccattt tgcaggacaa acctttggca 1979341 tatgggtcat tgtttttgca gtgctgggat tttctttccc atctttattt acgtggatca 1979401 gttcttatat tacgattttt ctcggcatta tcatgtttgg gatgggcctt acactgcaag 1979461 ccgatgattt caaagagctg gtcagaaagc cttggcaagt tattattgga gtaatagctc 1979521 agtatacgat catgccgctc gttgctttcg gcctcgcatt tgggcttcat cttccagctg 1979581 aaatcgcagt tggtgttatt cttgtcggct gctgtcccgg gggaactgca tctaatgtta 1979641 tgacattctt agcaaaagga aatactgccc tttctgttgc ggttacgaca atttctacct 1979701 tattggcacc tgttgtaaca ccgttgttga ttatgctgtt tgccaaagaa tggcttcctg 1979761 tctcgccggg gtctttgttt atctcaatct tacaggcggt tttatttccg atcattgcag 1979821 gtctgattgt caaaatgttt ttcagaaaac aagtggcaaa agccgtacat gcccttccgc 1979881 ttgtttctgt cattggcatc gttgcgattg tctcagctgt cgtcagcggc aatcgggaaa 1979941 atctgcttca atcggggttg ctcatttttt cagttgttat cctgcataac ggtatcggtt 1980001 atttactggg gtttctttgt gcaaagcttt taaaaatgga ttacccgtct caaaaagcga 1980061 ttgcaatcga agtcggcatg caaaactccg ggcttggggc tgcacttgcc acggctcatt 1980121 tctcaccgct atctgccgta ccaagcgcaa tattcagtgt gtggcataac ctttcaggtt 1980181 ctatgcttgc aacatattgg tcaaaaaaag tgaaaaagaa gcaagctgga tccaaaagca 1980241 gcaatctatc actttaaata tgcatcaaaa agggtacatc actttatcgt gatgtaccct 1980301 tttttattat ccttctaata aaagctgttc aggatcttcc agtaaatttt tgattgtcac 1980361 gaggaaacca accgcttctt taccgtctac aattcggtga tcataagata aagcgatata 1980421 catcatcgga cggttttcga aacgctcttc atcaatggct acagggcgca gctgaatctt 1980481 atgcatgccc agtataccga cttgcgggct gtttaaaatt ggagttgaca tcaatgaacc 1980541 gaaagtccct ccgtttgtaa tcgtgaagga gcctccctga agctcgctaa gggttaattt 1980601 attgtttctt gcttttttcg caagctcgcc gatctctttt tcgattcctg caaatgtcag 1980661 gcgatccgca tcccgtacaa ccggaacgac aagaccttca tcagcagcaa cagcgattcc 1980721 gatatcgtag aattttttaa cgatcaactc atcgccttga atttctgcat tcaacagcgg 1980781 atattttttc aatgcagcca cgaccgcttt cgtgaagaaa gacataaagc cgagcttcac 1980841 ttcattttgc tcaaaaaatt gatctttgcg gcgttttctg agattcatga cagccgtcat 1980901 gtccacttca ttaaatgtag tcagcatcgc tgatgtttgc tgtacctcta caaggcgttt 1980961 tgcaatcgtt tgtctgcggc gtgacatttt ttgcacttca acaggtttgt caaagctttg 1981021 ctgtgctttt tgagcctgag gctgctgctt ttgctgagga gccggttttg atgccggttt 1981081 ttcgtacgct tcgacatcct gcttgcgcac tcttccaagc ggatctccag ttggaacttg 1981141 agacaggtca attccttttt ctctcgcaag cttacgggcc gacggagaag cgatcgttct 1981201 tgattttgct tcagattgtg cttcctcgct cacctcttgt gcagctggtt cagcctgttt 1981261 ctcttctttt acgctttcct tgctttctgt tttctctgta ggagcagggg cagaactttc 1981321 acccgcgcct tctgaaatcg taccgataat ttctccgacc tggacggtat cacccgaatc 1981381 tttcaatacc tcttgaagta cacccgattc ttctgctgtc aattcaacat tcactttatc 1981441 cgtttctagt tcaagcagat attcaccctg ttctacatag tcaccaggct gctttaacca 1981501 ttgggctatt gttccttctg agattgattc tgctaattca ggtaccttaa tttccgccat 1981561 tttttcattt cccccttagt ttttgcgagt caagctatca gatacaatac gttcctgttc 1981621 ttttttatga actgtcggat ctccctctgc agggctggat cgtcttcttc gtccaatata 1981681 ttgaacgctt actccctctg gtgcaatctc tgtcaaatac gggctgatat aaccccaagc 1981741 ccccatgttc tgcggctctt cctgcaccca aacgatttct ttcaggttcg gaagttttgc 1981801 aaataattct ttgactcctt ttgccgggaa tggatacagc tgttcgattc tcgcaatgtg 1981861 aagccactct ttaccgtctt ctaacttatt aaaatgatcg ctaatgtcta tagacacttt 1981921 accgctggat aatacaagtc tggttacttt ttcatagtca tgagaaagtc ccgactgttc 1981981 ataaacaggc tggaagcggc tttcgctgag ctcctgcact tccgacaccg tatttgggtt 1982041 gcgaagaagg ctcttcggcg tcataatgac gagcggtctg atttcttcac gaagcagcat 1982101 tttagcctgt cttcttaaaa tatggaaata ctgtgccgcg cttgtcaggt tggcaaccgt 1982161 ccagttgttt tccgctgcaa gctgcaggaa tcgctcaatt cttccgcttg agtgctcagg 1982221 cccctgtccc tcgtaaccgt gcgggagcag catgactaat ccggattttt ggccccattt 1982281 cgcgcgtccg gcagaaataa attggtcaaa atacacttga gcagcgttgg caaaatctcc 1982341 gtactgtgct tcccacaaaa caagcgtttc cggtgaatgc acgttatagc cgtattcaaa 1982401 accgagaacc gatccttcag acagcgggct gttatgaaca gcaaatgatg tgctgcagtc 1982461 agataagtga tgaagcggca caaattcttt gcccgtctca ctgtcatgaa gcacaaggtt 1982521 tctttgggcg aacgttccgc gctcggaatc ctgtcctgtt aaacgaatcg gtgttccgtc 1982581 tttcaaaatt gaagcaaacg cgagtgattc tgccaaagac cattccactt ttctgtcatc 1982641 atcgaacgcc ttggcgcgtc tttctaaaat gcgctttagc ttgccgaaaa cattaaatga 1982701 ctccggccag ttgatcaatt cgccattcag cttgcggagc acatcaaaat caatcgaagt 1982761 gtccacatct gggaaaccgt ttgatacagg ctctggaagt tcaatttcac aagcagtgtg 1982821 ttccttttta gacggaactt tctgatatgc atcctcaatg cgcttcgtta ccgatttttc 1982881 gatgttttga acgacttcct cggtaaccac gccttctttt accagctttt cagcgaaaat 1982941 ttgtttgacg gtcggatgct ttctgacagc atcatacagc attggctgag tggttgacgg 1983001 ttcatccatt tcgttgtgtc catagcgtct gtacccgatc aaatcaatca gaaaatcctt 1983061 gttgaatgtt tttcggtatt cgaccgcaaa cttaacagct gaaagacaag cttcaggatc 1983121 gtccgcattc acgtgaacaa tcggaatttc ataacccttg gccaggtcgc tggcatattt 1983181 tgtcgatctg gattcagcgc tttctgttgt gaatccgatc atgttattgg cgataatatg 1983241 aatcgcaccg cctacttgat acccttttaa agagcttaaa ttcaatgttt cagctacaat 1983301 tccttcccca gggaatgcag cgtctccatg gattaaaatg gccagcgatt ttgtttcatc 1983361 ttgtaccggg tatccgcttt gtgttcgcgt ttcctgtgcc gctcttgtgc tgccttcaac 1983421 aatcggattg ataaattcca agtggctcgg gttgttcgct aacgtaatgc gcgctgattt 1983481 tgtttcagcg tcttgaagct cccgattcgc ccccaaatgg tatttgacat cccccgtcca 1983541 tccgtagctg attccaatgg atccctcaga cggtacaaga tctttgttcg gcgcatgctg 1983601 gaattcagag aagatgattt catacggttt gccgagcaca tgtgccaaga cattcaggcg 1983661 tcccctgtgc gccatcccga tgttgacact tgtcgtgcct gatttgacag attgtgcaat 1983721 aatgtcatca agcactggaa caagagcgtc cagaccctca atggaaaagc gcttctgccc 1983781 gacgaatgtg cggtgcaaaa actgctcaaa gccctctact tctgtcaatc tttccagcac 1983841 agctgacagc ttttcagctg agttcttctg gaacagctcg ccagattcaa tctttcttgt 1983901 cagccactcg cgctctttga agtcatgcac atggtcaaat tcaaaagaga tggttctttt 1983961 atacgtattt cgtaaatact gaatggcttc taaaccgttc gaaatgtttt taggagcgtc 1984021 tttgcagatg acagacgcag gtattgcttt tatttcctct tctgttagcc cgtaatcgga 1984081 taatggaaaa agttcgctct ttttctcatc ctttctgagc ggattgacgg aagcgttcaa 1984141 atggccatag gttcggatat cttctgcaag tctgactgcg gatgcgatct tttgaatcag 1984201 atcggctgta acacgtccct tttcttttgt tcccgaggcc tcttttatat cgcttggcgg 1984261 agcaccgagc tcgtcgaaca tttccttcaa atccgggtca atgctgttcg gatcctgggt 1984321 atactgatcg taaagctcca gcgcatagcc gaggttcgga ccgtaaaaat cttcccaatt 1984381 cattcgttgt ttcatactat tttgaaacat ttgaatatta cccccaactt aaataatcaa 1984441 gtgattgatt cactatcttg aaataacttt cgaacgctgt gtccaaaatt atgtaataaa 1984501 aacgcttcca acgatatttt accactgttt gcaatttgat tctaccttga ttgttcacaa 1984561 aatagtaaaa aacctttata aaaaacaaaa aatttaatca ttcgaaaaaa caaacgccaa 1984621 aaagcatagg attaagggct atcctatgct tttatgaagc agttttttca gcagcggata 1984681 caaaacatcc ggtagctgat caacatccgg gacaaatata ctgaattttc cgtacatatc 1984741 ctggatcgtc ttcatttgcg attcttctat ttctgagttg gagagaaaaa catttatcac 1984801 ttctattcct ctttttcggg cttcgataac cgcctcactt gtatcaacga tcccattttg 1984861 ttcgtagcca aatgcggccg gctctccatc tgagaaaaca attaagaact tttgcgcctc 1984921 gctgcgatgc agcatttttt tcgtcatctg cctaattgcg tacccgtcac ggttatcttc 1984981 ttctggctca agctgcataa tggccggtcc agaatcttgt cttaatgatg attggaaggg 1985041 aataaccgta ttgaaatagt ttggctggct tttttcggtt gcatcatttg tgtcctccca 1985101 aaaaccgaca atctgatgcg gaaccgctac cgatttcaac gcttcgtgaa acagcacgat 1985161 tcctcgtttt gtttcgtcca ttttgtcgaa catgctggcg gaacaatcga ccagcaatgt 1985221 aaaaactgcg tcgatttctg aagatggttc ttgctttttg tagaacaggc gcggatttcg 1985281 ctcagtgaag taacgaagaa gcttattgtt cagtctcccg gcatgaaggt ctgttctcgg 1985341 caatgttttt ttatgctcca gcgttttttg aatcatttgt ttcaaacgct tttgatacga 1985401 ttcaatcgtt tttgcctgct gtttataaga aagctcttct tcactggttg ccggctgcgg 1985461 ttctttataa attggaaatg catatttatt ttctttgccg tcagccatac ccgctccgtt 1985521 cggctggtct ttttgggact ccagcgcttc cagcttggaa tagtctttcc gtttcgtttg 1985581 tctggctgat ccttgaacag agccaagggc ctgatctcca tcgtcgcctt cccttgaagc 1985641 atcttttcct aaatctgatt ttgcgccgtg ttcaatatca aattgaagga agcttttaga 1985701 cggtgcttct gtttcccggt gccatgtcgg catttcttct tcatggatat cctcatcacc 1985761 gtctgattgt tttggaagcg tgatgtcatc actcagcttc ggcgcttttt tctcttcttc 1985821 aaataacggc tgttctgcag cttttgcgta atcaagctca ggcaaaaaga agtaggtgtt 1985881 caacatgtct ttatcgagta cctcttcaag tccgtccatg aggtcctcaa caattttcag 1985941 aacctgccgt gtcgaatctg cttcatacac acgcaagagc tgctgctcaa taaacgggcg 1986001 catcagatcg atatcttcac gcatggatgg aagggtctcg agcggcgatt ccgctgtgag 1986061 cttgaaatag atcgcgcaaa agagcgcatc ggtaaaaatg cttcgttcca aatttaaggt 1986121 cagctgggtt gagaaatgtt ttctgtacat gtcttttcgc ttcgcaaata catgtttcgt 1986181 acccgggcgc tcacgtttga tgcattcttc gatcctaatg tcttcaagca gcataaagag 1986241 ctgcttggca aaacttttaa acgtaagatg gcgatggata tcattcaaaa agttcgcaaa 1986301 ctcatgcagc gagctatatc ttgttccgac tgaacgcagg tagacgtcgc ttttcagacc 1986361 cgcttccatg tcctcagctg ccctgtcttt ccaaaagtgg ctcatataga ttttcttttc 1986421 aaatggattg taataggact gaacgccata ctccacttct accgcttcac tcttggtgag 1986481 tgttttggcc aaatcagtca gcatcataaa taaaaatgaa tcaatcgtgc tgtcgttaaa 1986541 tttgataaat ttcatcgcag ccccctcatt caaacagagt ttctgcaata tttcggacag 1986601 ccgctttttc ccgatcatca tcaagctttt ctacaattcc ccgctcaatg gcacgacgcg 1986661 gcggaatata agcagctaaa tcacatgtat cgattaaagc tctgatggat gccgcttctt 1986721 cagacacctg tccgttattg gcctgaacga tcaagtcaga ggaaagcgtg ataaatctgt 1986781 caatcaattt ctcgtctttc aaggctgact gagacatgag cacttgtttc agcagctcgc 1986841 ctttaatata aggcacatca atgatgacaa aacggttttt caacgcttca ttcagaggaa 1986901 cagttccgac atagccttca ttgatggctg caatgactcc gaaaccgctt ttagcccgta 1986961 tgacctcgcc tgtaaacgga tttgtcatca tttttctgta atctaataca ccgtttagaa 1987021 taggcagtgt ttccggcttc gccatattga tttcatctat ataaagaaaa tggccttcct 1987081 tcattgcctt tgtaacaggt cctgaaacaa actcgattgt tgcctggcca gattgatttt 1987141 caatcgtttt ataaccgacc aatgcctcag cgtccaagtc gactgaacag ttgacgctgt 1987201 gcatcggttt atgaaaatag ctggacaatg tttctgccag ctttgttttt cctgaacctg 1987261 taggcccttt cagcaggaca tttttcccca tggctaatgc aataatggcg tcaaataaaa 1987321 tggcttcatc ctccgcctca tagcctgatg ttcctataag cgattgaaac tctggggaaa 1987381 taggctgctc tttatatgat aaaagctttt gttgtatatc ttccggcaat gttaagtgct 1987441 gtagttgagt tgtcatagac agattccctt tcctattcat attccattaa cgagtatact 1987501 aaaaaagccc ctgtatgctc aatacaaaag ggcctggatg atattactgc ttctcgttat 1987561 ttcccaaaag ggctccgcag acaatacgcg caccggaatt gccgcttggg tttgtcagat 1987621 aatcgtccgc ttgttcatga ataataaatg cacttccgtc ctcgtcgaga atatttagtt 1987681 tacttccttt tttcagtgaa gtgtcaggcg cattcattat gacatctacc tttccatcag 1987741 caccgacttc aaggttcggc agatctccgg catgatgccc catcggatta ttaaagccgt 1987801 gttctttgtt cagtggatta aagggaccgc ccgctgattc aaaatccggc ctgacacaag 1987861 aacctttctc ataaatatga aaaccgagag aagcacctgg acgcaggctg tttgcggaaa 1987921 tatgaatatc gaggccttca tcatctgatt ctttgatctc tataaaaccg actgctttcc 1987981 cttcacgatt gaccagctgg acatgatgac caaacgctga cgtttcaacc actttttttt 1988041 ccggcacccg gttaggaggg tctggaggtt ttttttgtcc gcatccggca actcccagtg 1988101 ccgtcagcat catcaacagc aagagacggt gcatactgtc tcccccttgt tttttctaac 1988161 agtgtggtca atcattgtct ggtataaaca aaaaagccta taaaaggctt tttgtcatac 1988221 tcatttttaa aaataacttc ttgcgcccaa gtaccgctgt ttccaatacg aattgctgag 1988281 attggaaatg tcgacgcccg atgagcttgc atgaataaaa tcaccgccgc ctagataaat 1988341 ccccatgtga gacgggccgg atttatatgt ggtaaagaag acaaagtctc ctactgacgg 1988401 ctggctgact ttctgcatga cattccaata ccctgccgta ctcaatcttg atatagatga 1988461 tacattatta atgaggtaat aaatgaagcc gctgcaatca aaaccggcag gcgtgtttcc 1988521 gccccatcgg taaggcactc cgacatattt tttcgcttcc gttatcattc tgtcaatctt 1988581 cgaacctatt tgaatgtttg accctgagtt atcttttggc tttgttggct ttgtcggatt 1988641 tgaaggatta gattttgatg ctcccgaaat agtcagaacc tgcccgattt gcaacacatc 1988701 cgatgataaa ttgtttttat cacggatgct ttggacagtg actccgagcc gatttgcaat 1988761 tttccacagc gaatcgcctg cttttacctt gtacgtcgtt gtttttgagg gattggagtt 1988821 tgacggcttt ttggaaccgc tgtttccgtt cttaggtgaa ctgcttcctt ttattttgag 1988881 cacctgttta ggataaagtg tatctgatgt taagccattt aaggttttta attcggctac 1988941 agtcatattt aagctgtttg cgattttcca cagtgagtca ccaagcttga ccgtatatgt 1989001 actttttgaa gaacctgaag aattggaacc gctgtttttc tttgatccat ttgatccgct 1989061 tgaactgctt gtccctttga tcttaagctt ttgccccgga cgaatcaggt cactgctcag 1989121 gctgtttaag cttttaagct cagaaacact cattttatga tttttagcaa tcatccatag 1989181 ggaatcacca tatgcaactg tgtatgttga tgttttgctt gaattagatg gggatgtcgt 1989241 gctttttttg ctgctttcag gaaccttaag actttgtccg acataaagca ccgttgattt 1989301 caatttgttt tcggatttca gagctgatat tgtcgtatca tactggcggg aaagtttcca 1989361 aagagagtca ccgcttttta cttttatcgt ttttgcttcc gcgggtgctg cggccatcga 1989421 cgacccaaca actgcagaaa cagccaagcc ggctacaatc ttctttttca ttcattcaac 1989481 ctcctaaact gtttttttgc aaaaacagct agtattttgt ttccaaaaat ggcacacaac 1989541 tgttttatcg tcaatttttc agcaagttaa acccttttca aacatttggc gcagcatttt 1989601 cagcatcgtt cgacctttaa accttcaaat aaacatctaa cattttacat aagcacgata 1989661 tgtttttcga aagtctaagg aactatttaa gcgagggtaa aaatgatggt tttctattga 1989721 tgaacgaagc agtttctcct cctttcttgt ctatttttct aatcaattct ctatcggcgt 1989781 gtcaaatccc ttcctctgca ttcttatgaa atggcaaaaa gcctgttctt tcgataagaa 1989841 caggctttta cactatgcat ttgctgattg agttttttgt tttacagctt caagaatgct 1989901 gtcggctgct tttttagagc cgcctgccgc tttcagtgat tgtccaattt cttttgcctt 1989961 ttcagcatac gaacgattat tcattacttc ttgtatcgtc tctttcagta ggctttcaga 1990021 caattcttcc tttttaatta cttttcctgc gccgactttt tctacctgat ctgcgacaac 1990081 aaattggtcg cctcccatcg gaatgacaac gagcggggtt tcaaaataca aaccttcact 1990141 tgtgctgttc attccgccgt gggtcacaaa taagctggct cttttcaaga tctcaagctg 1990201 agggacatac gggcgtacaa tgaaattctc cggaatgtcg tttaactcac ttgttttaat 1990261 atgcttgccg atggaaagca caactttacc gtcaaagtcc ttacacactt caaggcattg 1990321 attaaaaaac tgcttttgat tattaaaaat ggttcccatt gaaataaaca gcacgttttc 1990381 attgtcaatc tgatcaaatg ggaaatcatt gtttccggct ctttctgtaa tggaaggacc 1990441 gacaaataca tatcgctcgc caaattgctc agccagtggc tgaaatcccc ttgatgtaaa 1990501 gacgattgtc aagtcaccat cagctaaaaa aacatcaaat ggcttcttga tctctgcttg 1990561 aaaatcagca tttaacgttt ctgcaagctg ctggtatgat tcataatgag gcgaatcttc 1990621 aagtgatcct ttcatgtacg ctcccatcat ttccttcgca aattcctcat tcatcgcaaa 1990681 ggttgtacac aatgaaaatc ttggcagctt cagcatgttg gcaatgactt tacccgcgag 1990741 aagatggtga tcatatatga cataatcata cgattcatgt ttgacttcct cataaatatg 1990801 agtcgcgata tccttacagg ctttcaaaaa agcgcagagc atttctgtga aatctctttc 1990861 ttcatcgccg gttgcgtttt tcccgaagta atctcctctg aaatcatgat actcacgaaa 1990921 ctctatatca agagctgtga ttttttcttt atattccttc actgcgtagt acgtaatgtt 1990981 ttctccccgg gatttcagct ccttcatcac accgatagag ggattaatat gcccttcacc 1991041 ggggaaaccg atcattaata cattagccat gcggcagcac ccttcctttg agaatttatg 1991101 taatatttta tacggtacta taaatgcata aacaggtaaa gtatttcact taattaatat 1991161 tcatcatata taacttttct accagtttat attccctgtc ttcaagacaa aaagcattca 1991221 gcttgaagcg aatgctttaa taaagatgcg aattcagtca ttttgtctca tgataggatt 1991281 cttaatcagg ccctttttat tatttttacg ttcttggtga aattaacgga tataatacac 1991341 cgtctttggc aaacgacatc ttccctgttt cctctgaaac cacgagcacc agtgcatccg 1991401 tatagcccga cataccaaga gccgcccggt gccgggttcc caaatggata tccacttcct 1991461 tcgtcgtcag cgggagcaca ttggctgctg acacgagttt gttttccctc actaataaag 1991521 cgccgtcatg aagagggttt ccgggaaaaa agatgctttc aattaatgaa gagctgatct 1991581 cggcgtgtag ggaggtgcct ttttgaataa aacgttcaac cgggtctgct ctttcaatca 1991641 caattaaagc tccatgctta tgttccgata aggctttaat cgccttggcc agctcaataa 1991701 atgccggcgt aaattcctca atgtatgatt gcaaataaaa ggaggatgca atcccctgca 1991761 tgtcctgaaa aacgtgcccc aaatcatcta attcacaaag gagacactgg tctttttcgt 1991821 gaagcgtttt caagattaga gatgcatcac ctaatatttg ctctaagtac acctgtattt 1991881 tccccttgaa cgcattttct gatatctgct catagcgcat agccttcatc tcctgtttaa 1991941 atttccaact tttcacgaat gcttatctta ttgatgcaca ttctattggt aaaggaggga 1992001 tgtaaagaat ggaaatcgaa agaatcattc agtatatttg caccttttta ggcgtgattt 1992061 cgctttcttt tatttatgcc caaatgttta gaaaaacgaa accgacaaaa aaagaatagg 1992121 cccggcgttc attgcttttt atacataaaa tgttataatt tctctcgtta tgaaaaagaa 1992181 acggagatca atgtatgaaa gaaactcaaa acgcccggga aaaaatcaaa cagctcttgc 1992241 acattttaat accgatattc attacccaag cggggctttc tctgatcact tttctagata 1992301 ctgtgatgtc agggaaagtc agccccgctg atttagctgg tgtcgccatt ggctcaagcc 1992361 tttggacccc tgtttacaca ggacttgcag gtatattaat ggcggtcacc ccgattgtcg 1992421 ctcagttatt aggtgcagag aaaaaacaga agattccctt tactgtttta caagctgtat 1992481 acgtggccgc gcttcttagc atcgccgttt tagtgattgg atatgctgca gttgacctta 1992541 ttcttggccg attgaacctt gatattcacg tgcatcagat tgctaaacac tttttaggct 1992601 ttttatcact gggaattttc cctttatttg tttacaccgt gttgagatca ttcatcgact 1992661 cattaggaaa aacgagagtc accatgatga ttacactcag ttctcttcca atcaattttg 1992721 tattgaatta tgtatttatc ttcgggaagt tcggaatgcc ggcacttgga ggtgtaggcg 1992781 cgggactggc atccgcgtta acttactggt gtatatgcat catcagtttt ttcattattc 1992841 ataaaaacgc accgttttct gaatacggga tttttcttac catgtataag ttctcttgga 1992901 aagcatgcaa aaatttgctc aaaatcgggc tgcctattgg gttcgccgtg ttttttgaaa 1992961 cgagcatttt cgcagctgtc acgcttctca tgagccattt tcatacagtg accatcgcgt 1993021 cccaccaggc agccatgaat tttgcgtctc ttttatatat gctgccgctt agcgtgtcca 1993081 tggctctaac aattgttgtc ggatttgaag cgggtgcagc ccgttttaag gatgcacgct 1993141 catatagctt aatcggcatc atgatggcga tcggcttttc tttgttcact gccgcctgta 1993201 tccttttatt cagagagcaa attgcgggca tgtacacttc tgaccccgat gtgctccggc 1993261 tgacacagca ctttttaatt tatgcgctat tttttcagct ttccgatgct gttgccgcac 1993321 cgatccaggg agcactcaga gggtacaaag atgtgaacta tacgcttgcg gccgcttttg 1993381 tctcttactg ggtcattggc cttccggtcg gttatatggt cggtacgttt acaagcctcg 1993441 gtgcattcgg ctattggatt ggattaatag cgggactcgc cgccggagca gttgggctgt 1993501 ttttcaggct ggcaaaactg caaaaacgtt attcgcaaaa acaacacatt taaaagaggt 1993561 gatcaatcat ggcaaaaaac aaaaaattat tcgagtatct ttcccagcat gcggaaacca 1993621 tcagttcaac atggtatgaa acaatcgagg agactgatcc caattccatt tatgcctcaa 1993681 cagaccctgt tgtcattcac aatttaaaga gccagaatct tgcctttaac tataaaataa 1993741 accgtatttt tatagatgat gaggacgtat acttgcctat actgaaagaa tgggcctttg 1993801 aagtcacaca ggatcaagag catttaaaaa ctcctatcca ctatattatt cgggagtttg 1993861 tcagagtgag agatttatat gtttcttatg tgaaagaatt tgtccatctc aatcagaata 1993921 ctgtgaaaag cgaagaagcc gaagacctgt atcacgccct tataaaagcg tttgatcttg 1993981 tgattcatat ttttatagaa gaaatgtaca aaaacacaag ccttcagctt caggcccaaa 1994041 aagatatgat tactgaattg agcgctccgg tcatcgtgct gtttcacagc gtcggactgc 1994101 tgcctttaat cggagatatt gatacagtcc gcgccaagct gattatggaa aacacactgc 1994161 atcaatgtgc gaaaaaaaag gtgacacaac tgtatattga tttgtcagga gtagctgtga 1994221 ttgatacgat ggttgcccat cagctgttca gtctgattga ggcgcttcgt ttaatcggtg 1994281 tttcttcaac tttgtctgga atccgtccgg aaatcgcgca aacagcggtt cagctaggtt 1994341 tgtctttcga aggtatttcc ttgagatcca ctctcgcttc agctattgca tcggacttaa 1994401 aattaaaaaa ggtataaggc ttaaggcctt ataccttttt gattaatcat tccattgata 1994461 cgtccaatat atttcttctt caaaccatgt tgccataaca ggttcattat ttttcaattt 1994521 ctcttcaagc tctctgagca tgccttctgt ttgtgtgcgg tgagctctta acgcattcat 1994581 tttaatatca gctacttctt tgatatcaag tacgacatca gcttcgccga gaacctcttc 1994641 tctgttgcgg gtaatggcca tgcagattgt acgcggacgg tcttctttct ttttgcggta 1994701 taatgcacgg ataaccgctt ccccgcatgc atcatggtca gggtgcacac cgtgtccggg 1994761 ataaaatgtg acaattaaac ttggttttac atcatctatg atctcttcca tgatatcagc 1994821 taaatactca tcgtcttcaa attcgagcgt tttgtcacgg agtccaagca tccgaaggtc 1994881 attgatatcc atttctttgc aagcgttgat gagctcttgt tttcttagca gcggcaacgt 1994941 ttcccgattc gcgaaaaatg gatcgcccat atttctgccc atttcaccta aagtggcgca 1995001 ggcatacgta acgggaatgt ctttttttct gtttaaggca atgaggcctg ccactccata 1995061 tgattcatca tcagggtgag gcaggattac tagtacatgt tctttcatta ttattcaccc 1995121 ttttctttaa actgtgaacg gtttttcgct gatttgcaga gaaatagcca gtttaccgcc 1995181 cggcaggtgt cccgccatta ataaacggtt ttcttcatct accgtgtatt cagtcaagcc 1995241 ttcagcataa atccagcctt cttctgtttt caagccaacg cggtaaggcc cgttgccttt 1995301 gatttttgcc tgatgataag tgacttttgc attgcgaata tacgcaacaa ccgtcatgtt 1995361 cttttcattt aagtgcgctg aataagaacc tgtggtggtt tctaaatgga tatatacagg 1995421 gcggtccgca tatcgttcta aagatgcttg cacatcttct tttatgatcg ctttcatgat 1995481 tgctcccctc tttcttcttt taaatactct gcacgttctg tatgtaattt gaccagctga 1995541 tatttcacag ccggttcgag ctgtgaattc acaatgcgct gaatcgcggc aaaatatttt 1995601 tccagcatcg gttttcggag tcttggatgt gttcgtttat ccaagagctc aagatcaatc 1995661 gcctctgcta ccgcttctgc gtcatcatgt gcgagagatc ggttattcca aagtgaagca 1995721 taggctttca ctatctcttt atcattgtcc atcgtcttgc tcctttatgt cttacataca 1995781 tgaaatgatt atacataata tatgcatcag ctgaaaagcc aaaggcctca atggcttttt 1995841 gacgcccgtt tccacttcac ttgtgaaaac gtaaacaaga gcagcgcagc ccatatacag 1995901 ctgaatgtaa aagccttcga gcttgaaaat ggctcatggt aaacaaacag cccgatcagc 1995961 agggtaatgg tcggcgcaat atattgtaag ataccgactt gatacagtgg cagccgtttc 1996021 gctccttccg caaacaataa gagcggcaaa gccgtaaaca caccggccaa aaagagaagc 1996081 agccacgtcc ctccgctttc tgcacccgct ggctgaacat gtccgctgaa cagcaaatac 1996141 cccaatgcaa tgggcataat catgaatgtt tccagcgtta aaccgatggc gctcggcagg 1996201 cttgttcttt ttttgcttaa cccgtacagc ccaaagctga atgcgagcag aagcgcaaca 1996261 taaggaatgg agccgtattg gaacgccgag atgatgacac cggctgccgc aatcgaaacg 1996321 gccactaatt gcaggcgatt cagtttttcc tttaaaaata aaatcccaag gagcactgat 1996381 acaagcggat taatgtaata gccaagacta gcctcaagca aaaagccatg gttgacagcc 1996441 catatgtata caaaccagtt gatcgaaatc aggatagaag caagaaataa agagaggatc 1996501 cctccgttct ttttcagaga gcgcaactcc tgccatccta ttttccattg ccgcaagaaa 1996561 aaaagtacga tacacataaa aacaaaagac catataatac gatgagccaa aatatcaaga 1996621 gccggcagct gttcgagaag cttccaatag agcggaaaca ggccccacat gataaatgaa 1996681 acggctgtgt aaataacgcc tttttttgtt tctgcatgtt gcattgatat ccctgccttt 1996741 ctttagagca tcttatatta tatcacgtga aagatctggt gggcatatac tattttgtcc 1996801 gtgaagaaag gatgtgaaga caatgtttga gtggaacaag tactttcctt tccacaatca 1996861 attttctaaa gaagcattaa aaaaagctga tccgaaagaa gttgaaacgt atgtcaatcg 1996921 tgtgatggaa agtgtgttcg gcagtgatta tgcggctcaa tttcctttcc gcgatcctct 1996981 cccccaaaaa gaacatcccg ccaaacctga tgcaaaacct gatgtcaaac ctgatattga 1997041 tatattcgaa acagcagacc atgtgtttgt aaaggtgcca atcagcgaag aatggctgga 1997101 acaagtgaga atcaaacaca catctcacga attatggttg gaaaacctcc caagagcaga 1997161 tcatccgaaa aaagtaaacc ttccttgttt agtcaaacgc aaaggaacaa aagccgtcta 1997221 taaggatggc cttctggaag tcatgtttca aaagcagcaa gactacaata tgtccgaggt 1997281 agaaatcatc cgataaaaaa cggcctgcaa tcgatgcagg ccgtttttta ttaatagaag 1997341 ccgggatatc ccccgtatgg cacgccggca ccaaaaccgt acggtccgcc tccatatcca 1997401 taagggccag gaggataggc atagggacga gaatagttaa acagcgcact cccgagaaaa 1997461 ccgcctaata aaccgccgac tagaggagcg ccaaacaaaa aaggactacg cgccggatat 1997521 ccggctggac ctgggattcc gcgtaaatac gaatgatgag ggtacatgat tttttcctcc 1997581 tttatgtctg cctatacgta aagtattcag caaggaagaa aaacgattgg gctacggact 1997641 gtctatgatt gttacatcac aagccctgcc aataacacac agccgagccc tgtaaccgaa 1997701 agaactgttg taagcagcgt ccaggtttga aatgtttctt tcatgctcaa gccgaaaaat 1997761 tcctttacca tccaaaatcc tgcatcattt acatgacacg caatgacact gccggctcct 1997821 gttgcaagca ccattaacgc agggtttaca ctgccagcct ccataagcgg agctgccatt 1997881 cccgctgtgg taagcgcagc cacggtagca gagcctagac acagacgcag aaccgcggcg 1997941 atggtccatg caacgaatag cggcgacatg tttgtttgac ggaaaaaatc agcgacataa 1998001 tcgccgactc cgccgtcaat cagcacctgt ttaaacgctc ctccccctcc tatgatgagc 1998061 agcatcatcg caatttgcga aattgattct gaaatagatc tgccgatttc ctgcatagat 1998121 attttacggg catatcccat cgtatagagt gcaagcaaca gcgaaatgag cattgccgtt 1998181 cccggagtgc cgataaattc tataatgtct tttccttttg aatgttcact caataataaa 1998241 gaaaaaattg ttgccattgc cataaagata accgggaata aagacgtgac agcactgatc 1998301 gcaaagcccg gtgtttcatc cagctgaaat tctttccttg gtcctaaccc cgataggttt 1998361 ccatgctttt gatacgcacc aggaaaccgt ttcatcgcaa atttattaaa taaaggcccg 1998421 gcaatcacag ttgtcggaac agcgatgatg attccaaaaa gcagcacctg gccaatatgg 1998481 gcaccatatg caactgagat agcagttgga gcaggatgcg ggggcaaaaa tccgtgagta 1998541 acatttaagg cggcggccat cgggattccc agatacagaa aaggcatttt taattcttta 1998601 gcaatcgcgt aaacaatcgg tatcaacaga acaagaccga cttcaaaaaa tagggcaatc 1998661 ccgatgataa aagaggcaac cacaaccgcc gcctgtattc gtttcctccc gaatttgtca 1998721 atcagcgtaa tggcgatccg gtagccgccc ccagcatctg agacaagcct cccaagcatc 1998781 gcgccaagtc caaacactaa agctaaatgc cccagctgcc cgccaattcc agtctcaatt 1998841 gaaagaacaa ttttattgat atccattcca agtccgatgg ctactaaaaa tgaaacgaca 1998901 atcagtgaga caaaggtatt taattttact ttaataatga gaaataacag aatcagcact 1998961 ccgacagcta caattaaaat cggcatggta cccctccaaa agtgttttat atgattctcg 1999021 cgacaatgtt ttggcgcttt tcatgcctag atgaacagaa agcgctttca ttaataacta 1999081 aaaacgtctt ggttatatga ttgttatctt ttgatcaact aatatgttca tactaatctc 1999141 ctaatcaatg actgtcaatc gtttttatga gcttgtctcg attacctacc gcctaaccca 1999201 atgatttatt agttatatgt tgattaactt ttggttatat gttatgtttt ttaaagttga 1999261 ctgccaatca ttatatctct ccattgtctg gaagcaaatg agacaatatg agaacagacg 1999321 gataacaact tcataagagg aggagtacac atgccattat tgcgttttga tgtaattgag 1999381 ggccgtgatg aaaaatcgct gcaattgtta ttagatactg ctcaccaagc gatggttgaa 1999441 gcatttggtg ttccggaaag agaccgttat caaattgtcc atcagcatcc cgcaaacgag 1999501 cttataatcc aggatgcggg attagggttt cagagaacca aggatatggt catcattagc 1999561 atgacaagca aagcaagaac cgaaagccaa aaggaaaaat tgtatgctct gcttgctgaa 1999621 aggctagaaa aaaaatgcga aatttcccct gacgacctca tggtatctat tactgagaat 1999681 ggtgacgcag actggagttt cggtctcggt gaggcgcaat ttttgaatgg aaaactataa 1999741 gatttcgtct ccccacaaaa aaaagaagag agagctccaa agaagctctc tcttttttca 1999801 taaatgcgga agtcatcagt atagaagcat ccagcaatac gaaaaacctg gatctccttt 1999861 tatatccggt ttaaatgcca attggaagct gactgggttt tggctgaaaa tataaaattt 1999921 tgctgatttg cataataaga tacatcataa tccccattta caataggttg gatgttatag 1999981 cttattgatc atttcctatt ttatatatcc ccttcatatg cacatgacat ttttgccaat 2000041 ccggaaatat cagtctgaca aatataaaaa gtcatgtaaa cgggtgtgaa ccgtacttac 2000101 atgactcacc atggaaacaa aggctctttt tcaggtgccg ctttccttat ttctcttctt 2000161 cacacactgt gtcaccaggc tcgcaaaatt gatcggccca tgcctgcatt tcttgaaata 2000221 cagcttgaag cgctgttcct ttttcagtca gcgtgtagat gactttgacc ggcgtttcag 2000281 ggagaacctg ccgttcgaca atctcgtttt gttcaagctc cttcaagcgc tctgccaaca 2000341 ttttttggct gatcatcggt attgtttccg ttatctcttt aaaccgtttc ggcccatcca 2000401 ttagcacatg gatgatcaga ccgttccatc gttttcccag caatgagaat gcggattcca 2000461 ttttagggca catcgtattt cccataagtc ttcatccctt catctattga ttgacatgta 2000521 ttcaatgatc cattacaata atctttcaag ttacatttag taagcttcta acttttctat 2000581 tatcatacca cgtttatccg aaggaggaaa cactatgacg aatactctgg atgttttaaa 2000641 agcacgtgca tctgtaaagg aatatgatac aaatgccccg atctctaagg aggagctgac 2000701 tgagctatta gaccttgcca ctaaagcgcc ttctgcttgg aaccttcagc attggcattt 2000761 tacagtattc cacagcgatg aatcaaaagc ggagcttctt cctgtagcgt ataatcaaaa 2000821 acaaatcgtt gagtcttctg ctgttgttgc cattttaggc gatttaaagg caaatgaaaa 2000881 cggtgaagaa gtttatgctg aattagcaag ccaaggctat attacggatg aaatcaaaca 2000941 aacattgctc ggccaaatca acggtgctta ccaaagcgag caattcgcac gtgattccgc 2001001 tttcttaaat gcttctttag ctgctatgca gcttatgatt gccgcaaaag caaaaggtta 2001061 tgacacttgc gcaatcggcg gatttaacaa agagcagttc caaaagcaat ttgatatcag 2001121 tgagcgctat gttccggtta tgcttatttc aatcggcaaa gcagtgaagc ctgcgcatca 2001181 aagcaaccgt ctgccgcttt caaaagtatc aacttggctg taaggatatg aaaaacctta 2001241 gtccgaaatc cggactaagg tttttttata caatcgcctc tttgtaccat tcacgagcct 2001301 gttcagcttc atgctgagtc agctgatggc ccccgtcctg ccagtaaacg gaggctgatg 2001361 ccccgctgtc acgcaaatag cggtaaagct cttctgattc ttccttcgtg caaagaggat 2001421 cgtatttccc ggcaccgata aaaacaggga gccccgccat atcaggcagc tcgatacccc 2001481 gaatcggaac cattggatga tgcagaatag ccccttttaa cacatcttta taatgaaaaa 2001541 gcaggcttgc cgcaatgttt gcgccgtttg aataaccgac tgcaatcact cggccgcgat 2001601 taaactgatg cgtttctgca gcctcgtcga taaaatcttt caattctctt gtccgcacca 2001661 caagatcctt ttcatcaaaa actccttcac tcagacgttt gaaaaatcgc ggcattccat 2001721 tttcaagcac cgatcctctg acaccaagca aatgggcatc agggtctata aaccgcccca 2001781 atgaaagcag atcgtgttca ttaccacccg tgccatgcaa cagcaaaagt acgttgtcag 2001841 atgttccttt ctcataaata tgcttcatta taaattcccc cttttaaagt tcaggtaaaa 2001901 tgtctgtaat ttgttgtcta tgtttctcca gccattcagg cagttttaag gaagtcccta 2001961 gctcagcaaa cgtttcatct gtcataaagc ccggttcatc tgtggcaatt tcaaataaga 2002021 taccgccttt ctccctaaaa taaactgatg taaagtattc cctgtcgaga atttctgacg 2002081 aaggcagatg gttttcagca ataatcggca gccatttcgc ctgttccttt ttcttagtcc 2002141 gaaacgctac atggtgtacc gtaccatatc ctccgactcc tcttttttca ggatgtaaat 2002201 ggacatcaat gacaccgccg accgccgctg aagatgccag tctgacaatc tggtcttctt 2002261 cggccacttt ggtgtatcca aagctttccg ttaacaattg tatggtcgcc tgcgggtcgt 2002321 aggaatatag cagcacacct ttcattcccg taattgcttc atttgttgtg atcccgtcag 2002381 gcgtccactc gcttttgccg cttttcgcat cctccatgat cgccagcgga aggtcttctg 2002441 tatcatcaaa aataagacct ttttcaccaa acaacgtttt ttcctctagg ctcagcccgc 2002501 ttttctcaag acgttccttc caaaaagaca gggagcctga gggaactgaa aagtacaccc 2002561 ggcccgcttg gccttttcct accgttccct gtccgcttcc ttggaacgga aaaaaggtca 2002621 ttattgtacc gggatctccg ttttgattcc caaagtaaaa atgatacgtt ccgggatcat 2002681 caaagtttac tgttttttta acgagcctga gcccaagcac ttctgtataa aatcgcaagt 2002741 tttcttgcgg atctctggcg aatgctgtga catggtgcaa tccttctgtt ttcattttct 2002801 cactcctatt tatctcgatt tcaagatatt tattatttta aacctttatt gaaaaggatg 2002861 caaaccatgt gttttgatta aataattgaa aaaatcattt ttttctaata attatcttgt 2002921 gatcttttct tacaactgct attatagtga gcattatcat gtttcaggag gaaagtaaat 2002981 ggttaaaaaa gcacttattg ttattctcat tcttttgcca ttcgttcagc tcgcgctttt 2003041 gccgcttgtg aatcgaatag aaccgattat gttcggcctg ccgtttttcc acttttggct 2003101 gctgctgtgg attattgtta cgccgttatg ctcgtttggc atttatcaga tgcaaaaaaa 2003161 agatggagga cttgaataat gcaagggaat ctgactgcac ttctcattac tgctattatt 2003221 gttttaaccg ttgtctgtat cggctttctc gccggaagag acaaatcctc acgtacttct 2003281 gtggaagaat ggtctgtcgg cggcagacgc ttcggcggtc ttctcgtctg gtttttagta 2003341 ggcgctgacc tttatacggc ctatactttc ttagggttga ccagtactgc ttttacaggc 2003401 ggaagtgttg catttttcgc cattccttat tctgtgttgg cctactttat cgcctacttc 2003461 ttcttgccaa aactttggaa agttgcgaaa attcataaat taacaacact cgcggattat 2003521 gcccgggaac gttttaacag taagcttttg gcaagcctcg ttgccatcgt tggggtactc 2003581 atgcttattc cgtacatatg ccttcagctg agcggcattc aagacacgct tcaggttgcc 2003641 ggcactggct atattaacgt aaaattcgtt gtgatcattt catttattct tgttgctctt 2003701 tacacattct tcagcgggat taaagggccc acatatacag ccatcattaa ggacatttta 2003761 gtatgggtca ttatgctgtt tatggtggtg tccctccctc tcattcattt taacggctgg 2003821 acgccaatga ttgacacgtt agtgaaggaa gcgccgcaaa tgctgacgat accgtcagaa 2003881 gggccaaaag gcattccttg gtttatcaca gcatctattg tttccgctct ggcacttttt 2003941 atgtgggcac atgccgctac aggtgttttc acggcgaaaa gcgctgatgc agtaagaaaa 2004001 aacagcatgt ttttgccgct ttataatatc gtgttaattt tggttatttt tcttggcttt 2004061 atcgcctttc ttgttctgcc ggaagataca aatccaaggc tggcgctgct gcatttgatt 2004121 caaacatctt acggcggcgt ggcacaaggc tttgcatatg ccactatcgc tcttgcttca 2004181 ttaatacctt gttccattat ggcaatcggc gcatcgaatt tattcgccaa caacctatac 2004241 cgggatttga ttcatccgaa tgtgtcgcaa agcaagctga ctcttgtcac acgttcaatg 2004301 gtgtttgttg tcatcggtct tgcgctgctg tttggaatgc tgttcccgac tgccttagtg 2004361 acacttcagc tattaggtgt atccggtatg gtgcaaatct tccctgcgat tgctgtcagc 2004421 ctgttctgga aaaaccaaac gaaagaagca acggttatcg gattattagc cggcctagcg 2004481 gtaacgttta ttgtgtatat cactcaatcc gcacatggca tttatgaagg attctgggga 2004541 ttggccgcca acatgatcgc tgtggtcatc ctgaatccgc tgttcgttaa aaacgcggga 2004601 tccaatcctg tcattgaagg tttatttggc aaaaaacaag acgctaatcc aaatcaaaag 2004661 ggcgcataaa aaaaccatac gcggcagccg cgtatggttt tttttacatt tcttttttca 2004721 gtgtttcaat tgccttttcc atttgcgtat cattatcaga cagcttcttt tgaagttcta 2004781 tcattaattt cgttgttgta tcgccagtca gtatgcctgt ttcattcagc ttctcttttt 2004841 tctggaactg tttgacgaca gatacaaaat cctggtcata catactgtta acctttacct 2004901 tgtaaccaag tgctttgagc attttctgag ccactttgac gtttgtgcct gtatcacctg 2004961 atttgtacgt tttatctgcg tccaaatacg gcagcttcgc gtaatcaggc agctctgctt 2005021 tcacttgagg cttgatgcct tttttgtgaa tccattcgcc atcagcagtc agccatttgg 2005081 caactgtcag tttgacggta gagccatcat catattcttt tgccgtttgt actgtacctt 2005141 tgccgaatgt cgtctcgccg attaacggta cgtttgacga ttcatgaagg gcagcggcca 2005201 taatttcggc tgcgcttgct gtaccgtcat ttactaaaac gacggtcggc ttggtcactt 2005261 tccgttcttt ttcggccttc atgacttctt ttgaaccgtt tttgtattca acctgcatga 2005321 tgtttttccc tttatcaatg aacaggttgc tcatcgtaat cgcctgttcc attaagccgc 2005381 ccgggttgcc tctcaagtct aaaatatagc ctttggcgcc ttttttctct aaactgtcaa 2005441 tcgcatctgt cagctcttta gctgttgttt cagagaaaga agtgatttga atttctccga 2005501 tgttgttgtc tttcatctct gaatagacag tctctacagg aatggtatcg cgcttaatgg 2005561 aaagatcgat attccccact cccgctctgt tcagttcaag cttcaccttt gtgccctttt 2005621 tgcctcggat taaagcgacg gcttcattta cattcatgcc ttttacgctt tttccattta 2005681 ccttaatgat ttggtccctc ggtttgatac cggctttttc agcaggtgaa cctttaattg 2005741 gggatacaat aaggatttct ccgtctttct cctctacttg ggctccgatt ccttcaaaag 2005801 atgctgaaat cgtctcgtcg aatgatttcg cttgctcttg atccatatat gtagaatacg 2005861 gatcatccag tgattgaatc attcctttaa ttgctccgtc tactaatttg tcatcatctg 2005921 ttttttggta ataatcactt ttgatttgct catacgcttt atttaatttg tcgaacttgc 2005981 tgtctcctgt gcttgctgat ttttggccca ggatactgga attgcccgta ataaataaag 2006041 taagcgccga agcgacaact gcagtgatca gcacaataaa aaacagtttt aattgccgtt 2006101 tcaattaaac accacctttt tcttcttaca ttattatcat ggacgaattc ttattcgtca 2006161 actcggagca gaaatgaaag agaaacgccc ttcttttgct tttcataaac ctatgtcttt 2006221 atacgacata tgataaggaa aaaggaggat tcgatattga gccgatattt agaaatgctg 2006281 tccttattcg gtgtcgcagg ggcgcaccca ggcgggctgg ctttttcaaa agcggtcttg 2006341 caaaaggctg caccctctcc ggatcagccg attcttgatg ccggatgcgg aacagggcaa 2006401 acggcggctt atttaggaca tttgctgtat cctgtaacag tcgttgataa agatcctatt 2006461 atgcttgaga aagcgaaaaa aagatttgcg aatgaagggc ttgccatccc tgcatatcag 2006521 gcggagctgg aacatctccc gttttcttct gagtcctttt cctgcgtcct gtcagaatcg 2006581 gtcctcagtt tttcacgcct gacatcctct cttcaagaaa tttcaagagt tttaaaaccc 2006641 agcgggatgc tgattggtat cgaagctgct ttaaaaaaac caatgccccc tgcagaaaag 2006701 aagcaaatga tggattttta cggatttact tgcttacatg aagaaagcga atggcataaa 2006761 ctcctaagat cctatggctt tcaaaaaaca gaagcgatgt cacttcttcc ggaagacatg 2006821 gaatttgaac caaccacaga aatggattta tcgcaaacga ttgatcccat ctattacgat 2006881 acgcttcaaa cacattatca gctcatgcag ttatatagtg agtacatggg tcattgtatt 2006941 tttatcgcgt acaagtaaaa cggcgtatcg ccccctgttt tcgtccaacc tttttttcct 2007001 atctatcata tgctgataga aagtcaggat aggaggggaa caatattgga gagatattat 2007061 catctttgca aaaaccatca aggtaaagtc gtcagaatta cagagagagg cgggagagtt 2007121 cacgtcggca gaattacccg tgtaacaaga gacagagttt ttatagctcc ggtcggcgga 2007181 gggccaagag gtttcggtta cggatattgg ggcggttatt ggggatatgg agcggcttac 2007241 gggatttccc tcggtttaat tgcaggagtg gctctggctg gtttattctt ctggtaagca 2007301 tagaacaaat gctagattca ccagacacaa tgaagcccgc ttatctagtg taagcgggct 2007361 tttcatttta aattttcttc actttttcaa agtactcttc aagcgttaaa tcattatctt 2007421 ggatgacctt tgcggctttt ttgcctacat agcgcagatg ccatggctca tattcatatt 2007481 tcgtgatatc ttctttattt ttcggatagc gaataataaa gccatattta taagcattgt 2007541 cctgcaccca tttcccgtct gccgtgcttc cgaacgcttc atttagctca aagccattgc 2007601 tccggctcga aatgtccatc gcaaggcctg tttgatgctc gctttcaccc gggtaagcga 2007661 ccgcttcctt tgccttcctt tcccctttta ggcttacttc attgtcaaaa atgactttct 2007721 gtctgtcata cgaacggtac cctgagacag ctgccagttc atagccttcc tttttggcag 2007781 catcgaacat tgtttttaat gcgtcggccg cttcttttct gatgtaacgt ttttgaatct 2007841 tttcttcaaa agaaaactct acatcaggta tgacaagatc gctaggttca tagtttccgg 2007901 gcagtgcata ttgtttattg acaagcgcga gtatattttc tggattttga atggtttcca 2007961 gaccatcgac ttttttaata tcattgaaat actggctttc caatgaaaac tcactgtttt 2008021 gagtgtttga ttttttgctg tcagctgttt tttgttctgt ttgctttgtt tctgctgtgg 2008081 ttttcgtatc cttttgagca tctccgttcg acatgctgca gccggctccg actattgccg 2008141 ttacactcag agcggcagcc agtgagaacc atttaccgga ctttttcata ttacattacc 2008201 ttccttttat caatcgtttc cgcatgcata aagaagaggc tgccggcacc cagcacgcct 2008261 cttgatatat tttattgtga tacggaatgt aaagccactt ctatcatatc atgaaatgtc 2008321 gtttgacgct cttccgctgt cgtttcttct cctgttaata cgtgatcact cacggtgaga 2008381 attgacaggg cttttcttcc gtgcttcgct gctaatgtat acaatgcagt tgtttccatt 2008441 tcaacgccaa gcacaccgta ttttgcaagt ttttcaattt gcgaatcgtc attgtagaac 2008501 tggtcagctg taaatacgct tcctacagtc accggcacac ctttatcctt tgcggcatca 2008561 taggcatttt ttaaaagctc gaaatctgcg caaggcgcaa aatcaacgct tccgaaagca 2008621 actctgttca tttgtgaatc agttgaggag gtcatcgcca aaatgacgtc tcgcactttg 2008681 acatctttac gaatagcgcc gcaggaaccg actcttatta gattttgcac atcgtagctt 2008741 tgaattaatt cattcacata aattgaaata gacggaactc ccattcccgt gccttgtact 2008801 gagatttttt tacctttata tgtacccgta aatccataca tgcctctgac ttcattgtag 2008861 cattctacat tttcaagata cgtttctgca ataaattttg ctctgagagg atctcccggc 2008921 aaaagcacag tatccgcaat ttgtcctttt tcagcaccta tatgtacact catctcatat 2008981 cctcctgtaa atctaaatta tcatccagcc cgtccatttt acaacgaatg tcatgatgaa 2009041 acaaacttca gcattgatta taaaggaata tatcgaaaaa agaaatgttc gaggatctgt 2009101 taggcacttc ctcagaaaaa cggataatcg gggtgttaat ttgaaaacct aaccgcagga 2009161 aggaggggtg ggacatgggt aaaaaacatc gtaaccggat caccggccaa aaaaagaaca 2009221 atcatatacc tgaaaaagat atcattgcag ctgaagaagc acacgggaaa gaatattccg 2009281 ctgccaaacg caagccttaa aactgcagaa aactgcgggt ttccgcagtt ttcttttcat 2009341 tatgtcgttt gtacaatcag acgattgatt ttcctccagc cggcgggaag cagttgataa 2009401 tatgttttcc cttttctgcc ttcatcaatc aggatcacgt cccctgtggc catgaatctt 2009461 gcatcataat cactcggaac agtgtcgaat acattaaaca aagagaatgc tcttttcagc 2009521 acgtcttgat gatcgctccc gttcagttca gttcgataga cggctctgta gccctttttt 2009581 tcgccaaacc ggggtgtctg aaatattgtc acgtcatagg aacaagactt ctttttaaac 2009641 acggataaca tcatcaagat cccctccctt ttatttcttt aacatattgg cgtttttgct 2009701 gtgttttcct ctctctattt ttgtcgaaac cgcttaatct tttcgtcaaa accttttact 2009761 aggaaaaaca gaagcaagcc gaggctaaag cctcctaaca cgtctgtcac aaaatgaacc 2009821 cccagataca ctctgcttat gccgactaaa acagcaatta caccggctat gatatatacc 2009881 atttttttat gcttagacaa aaacgggaga tgtttcacta aaaagtaagc aataacagga 2009941 tagacacaag cagcattcat ggaatggccg ctcggaaaac tgaaggatga ttcatgaacc 2010001 agcggtgcaa aatcaggcct cactctttcg atccattctt ttaagacttt gtttaacagc 2010061 cgatctgtgc cgaatactaa gagcatcaac aggccgtccc atgtttttct gtagaaaaac 2010121 atgcctgctc caatgatgac aattagaggg agcagaaaag aagaagcacc aagatgcgtg 2010181 atccccgtca tgacttcatt aagccatggc tgacggatca aaacagctgc cttgcttatt 2010241 gcttcatctg cagattgaac agcatttgta tgaatggccg cagctagaat taaaaagaaa 2010301 agaaacaaac taacgggctt gtacaatttt aaccacctca attttcacag aagtcataga 2010361 acatgaataa taaaaccgga gctgaccgct ccggttttaa gcctcactca tcttcatcca 2010421 gctcttcatc tatcatacat ttttctatca aataatcaaa ggtaatatca gcgatttcaa 2010481 acagctcatc ctcactcggt atgtagcccc gtcttgcaag ctctctgtaa aaaaattcag 2010541 cgatttcttc cgtatcaatc acaagatcta tttctttcat ctccgtaccg cctccttttt 2010601 tatgttttat gaaaaaacag gctgaattat acccggtgtt ctaaacaatt ctttcagtca 2010661 tatattgaat aaaaaacgag ccatgggagg ctgacgctat gattgctaaa atgatggaag 2010721 cactggacgg agaaagattt gatatcataa tggaaaaaac gctcaaagga atgacgcgtg 2010781 tgatgatttg gggctgtctg ccatattttt tatatgtctt gatccgtatg ttcacaaatt 2010841 aactgaaatg ctcttttaaa ctttccaaaa caaacatcat catgtcttta tattcttcat 2010901 cctgaaacat ttcgtacaga attttgtagt cattataaat atccagaagc tcatcaacaa 2010961 ttgacacagc aaggatgtga agggtatctt gatcttcatc accgccttca aactgaagaa 2011021 gagcagacga tgcgatatct tcgccgatct catggccagt ttctccgaca taatggacaa 2011081 acaacagctg atgcacaaac tggtccattt catattttct aagcaccagc gtgagatcct 2011141 cttcctccgt ttcaagccac tctccatcct ttaaacgggt cagctcataa atgatatctt 2011201 cccagccatc ttctaaatat ctccaaattt ctgttctatg gccgataatg cgaaagagtt 2011261 cttttccata atctttaaca taaacaacgt ccccaataag gaattcatac tcaatatcaa 2011321 gcttctccat gtcgacaatg acaccctcat aatctttata aagctgaata gatgattcaa 2011381 agtataaaac ttcgttatga ttgacttcat aaagatagtg tttatcaatt tggtgtactt 2011441 ttgtgatggt gccgactgtt ccatacataa tgacgactac gatatcccct acttggaatt 2011501 tcggtttatt ttgcttcatg gtgtctcccc ctcgccgcaa catttctcat acgctatcgt 2011561 atgccgggtg aagccaattc gcatgggcat gaaaaccaaa ggaaatatcc aattatggta 2011621 tgggtatgga cataaaaaaa tccgcagtga tctgcggatg aaacagctat tatctgccgt 2011681 gcacttcaga ctcgtattga tcccaagctt catcaaacgt cgccatcgtg tgaaggtaat 2011741 cagcattcag ctccaaatat gaactgattt catgataatc ggttgatgtt tttggaaagc 2011801 tgtgatcctc atacgcctga ttggcaaatt cactgatgct gtccttcggc ttagggtgtc 2011861 tgtatttcaa taaatagtga taaaaggatt tcatgggttt cccctcctga tgtctgtctt 2011921 ttgttgttct attatacagt tcaagtgtaa aattacaaca aaagaatact gaaacatgac 2011981 tcaggagaag tcaaaatagt tgcgtttcaa aattctttct gtctccatga gctgctgata 2012041 tgtcaggctt tcaggcagtt tttttgtttg aattaaaagc agctgatcct caatctcttt 2012101 aaccgtgttt tcctcttgat aggtcatacc gcaggaagaa cataccatgg caggggtgtc 2012161 tgtcagttct atagccctcg ttccatcagg gagctcccag tacaccgtgt tcctgccggg 2012221 caccgcttcg agctcgccgc accattcgca tgttttcatg aagaatcccc tccgcattca 2012281 gtctctttct gttttttctg ctgcgccaaa aatttctttt ctttgagctg atctcttttc 2012341 tcacgccgat cttttaatgt ttcatgctcc ggatttgcga tgtatgcctc tctccttttg 2012401 attctgtcta cattttcagg tgtaaacgaa acttctttgt cagcaaaaat ggcactcagc 2012461 ccgatcggct cctttttgtc agcggtttca gggaaaacgg actcaaaata ggcgtctgcc 2012521 tgattgggga tataattctc tggttccgga tatgacgtaa tcacaccttc aaaatttctt 2012581 aagatcactt tgtcaggact ttgtgacagg acatagtttg gctgcagggc gattttacct 2012641 cctccgcctg gtgcgtcaac gacaaaggta ggaaccgcat agcctgaggt atgacctctc 2012701 agcccttcaa tgatctccaa acctttggaa acaggagctc tgaaatgccc tattccttct 2012761 gacagatcac attggtaaat ataataagga cggactctga tttttaccaa gtcatgcatg 2012821 agctttttca taattggaac cgaatcatta atacctgcta atacgacagc ctgatttccg 2012881 accggcactc ccgcgttcac cagcttttca catgcctcaa cggattcttc tgtcatttcg 2012941 atgcttgtgt taaaatgggt gttcagccag accggatgat attttttcaa tatctcgcac 2013001 agatgatcgg taatgcgctg cggaaagacg acgggagctc ttgttccgat tctgatgact 2013061 tccagatgcg gaatgctgcg cagctctttt aaaatatatt ctaaaatttg gtcgttgatg 2013121 agcagcccat caccgcctga aattaaacaa tcgcggattt cgggtgtttc ccggatataa 2013181 gcaattgcag catcaagctg ttttttgggg acgcccattc cgatttgtcc ggaaaagcgc 2013241 cttcttgtgc agtagcggca gtacatggaa cattgattcg tgacaagaaa cagcacacgg 2013301 tcgggatagc ggtgtgtcag accgggtacc ggtgaatctt catcctcatg aagcgggtct 2013361 tccagatcgt attttgtttt gtgcatttct tcagaaagcg gcacagactg catgcgtacc 2013421 gggcatctcg gattgtcggg gtccattaaa gaagcatagt aaggtgtaat atttaagggg 2013481 atcgttttgg tagaaattct gacgccttcc tcttcatcct cggtcagatt aatgactttc 2013541 tttaaatcat ctaacgttct tacagtgtgt gtcagctgcc aaagccaatc gttccatttc 2013601 tcttccggaa cgtccttcca taactcgatc tccttccaat gccgtttcgg tttataccat 2013661 ttgtttttca aacgaactcc tcctcgcgca tattttgact tacagttgct tgcaccaaat 2013721 attcatgttt tcaaggcctt cggctataaa gcaattattg atcagccttc cgccatactg 2013781 ataacctgaa tggtacaaca cagcattcat cccaaaagac gaagcacggg cgagagaaaa 2013841 cacatgaacg atatcctctc cagccatttc tttttctaac gcctcgatta aaaagcttgt 2013901 taacgaatgg ccgcgatatt ccggcagcac agcgcaatcg gttatttctg catgcccaag 2013961 ctctggattg atttctgcgc ttgctgcgct gatcaggcgg tcatgatcaa gcatgatata 2014021 atacaccgta tttgcattca tcgtcttttc aatataagcg gggtcaaata ccggggttgg 2014081 gtacgtgcgg aatacttttt tatacagcat cgatagctgg tacatgtcgt ttgtttctgc 2014141 ttttctcatc gtaaaaacgg gtgtactgtc gttgcgaaga cggggcgctg tgcgatatat 2014201 ggcttcgatg atctcctgtt cctctgtata agaatctgtt tgtctccggc tttctgaaag 2014261 gtaacgtacc atgacacaag ccgaatggcc gagataatag ccctttagat agccctccgg 2014321 cgcaaataat tgtttggcaa ggatcggctc atcatgctgc ttcgcataga caatgatttt 2014381 ttctgcattc tcttcttttg ccgctgccac gatatccggc agggccttct caatggctcc 2014441 gtcataacga accactctga ttcgtttatt aaagccgtca tggtccaaaa ctgctgtgac 2014501 accgctactc tttattgact tgagcatccg catcctcccc atctgtatga aggccgcacc 2014561 aatccatgac aaaaagtgca ataattttag cagattctat catggcttca acctcaatgt 2014621 attcattggc ctgatgagcc gtttttgttt cccccggccc gaaaacgatc actggtgtat 2014681 ctcctgcatg gtacaaaagc cctccatccg ttccccacgg ggaagcctca ataatcggct 2014741 ctgtctgttt cattttttga taggctgatt gcagcacaga aattaaaggg tgatcatcag 2014801 gtaaatcatt cggcagccat tgagcgccaa accattcgac ttgtacggga tggcgtttaa 2014861 accattcgtc atggtattct aaatccttca gccagttttc caattcaagt tttacagctt 2014921 ctggtttctc atggggagca attccgcatc tcccttctat gacgacacgg tctgcaactg 2014981 aagatggcca ggcaccgcct gagatggtgc cgatattcac cggtaccggt attgggatat 2015041 tgtcatacag cggatctgaa attctcgcat tgcggacttt ctccagctct tgtatcgctg 2015101 tgataacgtg catgcttttt tcaatcgcgc ttaccccttc atagcgtgtg cccccatgtg 2015161 cggataatcc cttcacagtg atccgaaacc acatcgaacc ctgctgctta ataaatagtt 2015221 tcatattcgt cggttcagga atcagcgccc cgtcagcacg atagcctctc atgatggcgg 2015281 aaagtgtacc ggcgccgccg cactcttcat ctacaacact ctgaaacaat acatctccct 2015341 tcagtttgac atcgcaggcg tgcagggctt ctaaagcaaa aagaagggct gtattgcctc 2015401 ccttcatatc cgttgagccg cggccgtata ttttaccgtt ttcttcgaca gcttgatacg 2015461 gttcatactt ccaatccttt acgcttcctt caggcacaac atcgatatgg ccgttcaaaa 2015521 tcagggacct gcctccgccg gctcccgttt ttttagccac gatattcggg ctctcatgaa 2015581 aatcggatcg gttagattta aagtagggat gctgttttaa ttgctttatg cttggctccc 2015641 atacatcaat gtccatatga aattgccgca gcttttcaag cacaacagct tgggcgttaa 2015701 actctgaccc caatgtgctt ttttccccaa tcagcctttt gagaagacga atggctttgg 2015761 ccgaatgctg atcaagccac tcgattactt ttctttcaat gtcttgcatc ctcattcccc 2015821 ctcttaagaa aaaggcatat ctattttgat ttcagcttct gtcagcctcg tcacctcatc 2015881 gattgtcgag ccattcatca gctcttttaa aatgaagtga tggctatcga cctcaagaac 2015941 cgctttttcg gtaataatca aatctacaca gcctgcagca gttaatggca gcgtacatct 2016001 ttctgttaat ttaggccttc ccttttgatc tgtatgactc atgacgacaa ccactttttt 2016061 cgctttttgg gcaagctcca tcgccccgcc cataccaggc accttttttc ccggaacaag 2016121 ccaatttgcc aaatctcctg attggctcac ctgcagggcg cctaaaatcg taatgtcaat 2016181 tttgcctttt ctgatcatcg caaaagacat ggttgtatca aaataagaag ccccttttac 2016241 agcgcggaca ggatatcccg cggcgttgca taaatgcgca tcctcttctc ccttttcggg 2016301 actttctcca atgccaagga caccgttttc cgcttgaaac atgacctgca tgtcaggctt 2016361 caaaaagttc ggtaccaagg aagggatacc gataccgaga ttcacaatca tgccctgctt 2016421 aatttcagta gcagcgcgtt ttgcaatctg ttctctttct gctactccca agcccatttc 2016481 cacttcactc cctcgcttcg tacaaccccc tcaacaaaaa cccccggtgt gacaatcatt 2016541 tcttcagaaa tctcccccat cggaacgata cgctcagctt cggcaaaggt tctcctggcg 2016601 gccattgcca taagcgggtt catattgcgc gcggttttgt catacgttag attgccgaat 2016661 tcatctgcaa tgtaagcatt gatgaaagca aaatcagcag tcagcgcctc ttcaatcaag 2016721 tatcgttttc ccgccactgt tacgatgtcc tttttttcgc aaaccatttg attatcaatg 2016781 cccacgtcgg ttaaaatacc gccaagcccc gctccgccgg cgcgaatccg ttccgcaagc 2016841 gttccctgag gtgaaaattg aacctctaac gtcccctctg tcatctgttt tccggctact 2016901 ggattggaac cgatatgcga ggcgatcagg gttttgaccc gttgattaac aataagcggg 2016961 ccgattccga tatccgggaa accggcgtca ttgcaaatca cagtcaaatc cgttacaccg 2017021 ctgtccaata tcgcttcaat caatgaagga ggcgacccga ctcccccaaa accgccaaac 2017081 atcagaaccg atccatcccg aacatctgca attgctgtgt caatgctgat tgctttttga 2017141 aatggcgcca tttaatgtca atcctttttt aagttttttt cgaccgctgc aactgtttct 2017201 gaaaaaatag agataagctc ttccatttca ccgtctgaaa tagtaaaagg aggagcaata 2017261 atgacagcat ctccttctcc actgtctatt ccagctttgg aaggataaac aatcagcccg 2017321 cgttttttcg cctcgctgac aataagctgg gttatcgcct gctctggcgg aaacactttc 2017381 ttcgtttttt ggtctgccac aaattcaatg cctaatagca gtccttttcc gcgcacctca 2017441 cctataatgc cgctttgaga tgccgcctca tcaagcttct tcttcagcac agcgcccttt 2017501 ttttctgatt gtttgatcaa gccgtgcttt aacacatatc gcaaaacttc aagagcagct 2017561 ttggctgaat agggatgtgc actatatgtg tgaccgctca taatcacacc tgacccttgt 2017621 tttatggttt caataataga atcagatacg acggcagcag caataggtgc ataccccgca 2017681 ccgagtccct tccccagtac agcaatatca ggtacggtat cccaatgctc tgtcgcgagc 2017741 atccttcctg ttctcccaag ccccgtcatc acttcatctg caataaaaag cacatcgtgt 2017801 gtgcggcata cctcacttaa tctctcataa tatcccggag gcggagtaat cgctgctcct 2017861 gcagcaccaa taataggctc agccacaaag ccggcgatga attggcttcc gattctttta 2017921 atcatggtgt ccagttcatc agctgcagtc tgaacaaagt cttcttccgt ctcgtgattc 2017981 agccgataaa tatgtggagc tgagatagct ggataccgct caatgagatg ggtgaaccgg 2018041 tatctccttt cataaaaacc agacaatgaa agcgctccca aagttattcc gtggtaactg 2018101 ctccatcgag acaaaaagat ggatttttgt gtttgctttt tttcctgcca atactgaatg 2018161 gcgattttca tagctgtttc tatcgcttct gatccgctgt tgacaaaaaa agaccaattc 2018221 acatctccgg gcagctcctg tgccaagaga gcggctaatt gctcggcggg ctcactcgta 2018281 aactgtgagc ggtaagcaaa agacacctga tcaagctgtt ctttcagctt ctcagtcaca 2018341 tcacgaactc cgtggccgat attacatgtc accgcacctg acgagccgtc gagatatttt 2018401 tttccggtct gatcataaac atatgaaccc ttcgcataac tgacaaccgg ataggccgag 2018461 ctaagctctg gcttaatcaa ataactgctc atgctcccac ctcaaaaccc cttttaccat 2018521 attgtatgag tgtccaaatg gcggcatgac gttccccgca aaaacttttt cacataaaaa 2018581 gagccttcct aataaggaag gctcttttga aatttcagca tctagcaaat aaaagcggct 2018641 ccaacaataa ttaataaaat gaacaagaca acaattaaca caaatgtatt tgtcccgcag 2018701 ccaaatccgt aaccgtaccc agagtatcca tacatgctgt tttcatcctt tcttatcacg 2018761 atatacgaca ttttatgcgg gccaagtccc aaatggtttg tgcaaacgcc tatttcatgt 2018821 aaggaaataa tgaaatacag tatgcacccg ctcatatttt ttaaacgtca gcttttcgta 2018881 aaactgagtt gcaccgtcag tgcttgcagc cactaagtag gctgcttcca ttcctagtga 2018941 tttggcgatg gacagcattt ctttcactaa gatactgccg tagcccttcc tttgaaactg 2019001 atctaaaatt gccacttctt cgattttagc cgttttctct tgatgatcga taaacagctc 2019061 gccgcaccca atgggaactt tctgtgcctg gtcgctgtaa caaacaacaa gaatgattat 2019121 atctgcttca tagaaaggat attttctttt taatttttgt tcagcgattg cttctccaat 2019181 ataaatggaa tcgtaaattt tcataataga agatccgtcg ctaagacttt ttgccgtccc 2019241 ccatgcggtt aaaggatgtc ccatctgccc cttccagtca ctaagcttca tgtcatatag 2019301 tagctcatcc tcgacgacaa aaccgctttt tacaagtgac tgcttcaaac cgagcggaaa 2019361 aacatgctgc ggcgacgctt ttaaatggag ataattcgca tcaagcagct ttggtacgga 2019421 gggtaaaaag ttaagtaacc gctccaatgg aaacgtatca tggagctgaa caaagttatg 2019481 agaaaaaatt tgcggaagct gcggatctct gtatacgctg taatgatcaa acgatgccga 2019541 ttcagacgtt aacaatatat attgatgttc cgtttttgaa taatgtcctg tcatgaacgt 2019601 ctccttttta tgacctatac ctttactctg ttgcaatatt caatttcttt ataatctcat 2019661 cgtacaccgg ataaaacggc tttccaattg gaaattgctg aatatttcgg aaagaagcgg 2019721 agattggctt ctgatgtaaa aaaaacttcc ttgttacttg ttcactaatc gggtgaaaga 2019781 cgccgtttag aaacaaaaac ggctcgcgtt cgatgaaaaa cagacgtcgg ccaggcggat 2019841 ttttgatcaa ttcagatcgt ttccacgtaa tcggcggccc ttccggaagc gtctccatct 2019901 cttcttttcc aattgtcact atgtcttttc tttgaaattg ataaaattga aacgcatact 2019961 ggtccacaat tcgccttttt tttccggctt cgatataaaa tattgcagga tggtcagctt 2020021 cctttactaa aatataattc ggaatgttta aaattttgcc aatcctatat tggaataaat 2020081 atgggtctgg aacagcgaca gtccgattta gatacaaaaa accccacttt tctccaacag 2020141 gatgccttac accctgatca aaaaaataca cattttgatc tgaacctttt acaaaagagc 2020201 cgtcaatcaa atcggcgggc agaaaccgat atgcattttg aaatgaatct ggggttttat 2020261 aggttgtgtc taatacttca tttatcggca gaaatggggt aaagttgttg agtctcgccc 2020321 aaaaaattgc gtcgccatga ttccaatgct tcatatcatc atcccagtag cctccaaatt 2020381 tatggtgaat gagattaagt aacgaacggc gatgcataac tgagcaatga tcaacttgaa 2020441 aagcggcctg atcaagcact gcattggcat ttctgtagaa atgtgagatt tcctctcccc 2020501 tttcgtttac atgtacaact ttttgttttg aatagaccgc ctgcgcttca ggcttatgtg 2020561 aaaactcttg caccatacgg ctcagccgct caggatgata aacagtgtcg tcagtaagat 2020621 aggaaatgta atcgccgtct gcaaatggga gcgcactgtt aattaatgtg gcataacggg 2020681 ctgtttttaa tcgatctgca ggatgcacga aactgttatg atattgaatg cgccggtcat 2020741 ggagatactt gtgaatcacc gcagttgttt ctgcattcga atgatcatcc atgataaaaa 2020801 gctcccaaag atcatgcgtt tgctgtatca cgctttcgat cgctttttgc aaataatcgg 2020861 gtttgttgta acttgttaaa ataatagaca ctttctctcc catctatacc gcctcccgcc 2020921 gtcaaacata aaaacggctc cgcagcaagc agagcctctg tcatcattta aaaagcaccc 2020981 cagcttacaa cacttgagag tgaaacatga gatctcgtgt tatttaacgg gttttggaaa 2021041 ataaccaaat cagtcagaac ttcttttacg atgacatttt gaagtgtatc tccgttgatc 2021101 aaattgactt ttgaaaccgg tacgcccagc tcttttgcaa aaacaagctg gcgtctgagg 2021161 tcagatggat ttccttcaga agacgattga cgtatcagca gaatcagcaa aagcaaaata 2021221 aaatgcagat catcttggtt ttcttctcga tccacttgtt tctctaaatc caaatcatcc 2021281 ctctccctta tccttatctc tgtttcacaa tatgtgcgac ttcgatttat ggtataggct 2021341 atgtccactc cattaaaaaa tcagcatttt ccttaaatag atgaaaaata gatcaggtac 2021401 ggcgttcgac tcataccaaa taacagccgg aagaatatga ataacgtgag ttcactatcg 2021461 aataggaggt gtgtgtaatg agctctgaaa atgcacagtt aaaaaaggat ttaattaaag 2021521 ccgttttaag ccctttattt ccaactgcaa cagaaggagg agaaaatatg gatagtaatc 2021581 ttaaagcctt gcttgatgct gccatcgatc aaaaagtaga tgaaagtgaa acggttacgg 2021641 cagaatctat tttagaccct tctcttccgg caagatggat ttttgccaga attacgccag 2021701 gcactacaat cagcattgtg actgattcag gtgacatgat cggaccggtt gttttcgttg 2021761 ctttcgatca ggttcacggg atcgtatttg taacacagga aagctccgtc actccggcag 2021821 gccaagctac aacattaatt gatgtagaca aagtagaaag cgttacgttc ttttcataac 2021881 atccgatgaa agtcttgtat atccagtcgg gatacggagg aatatacagt tattttgatc 2021941 gctgggctga agaatgtttt cagaacactc atacagagta tatgattgca gataaacctg 2022001 aagcagaatc tttgatgaag atcgaagcgt ttcagccgga tttcacactt atgatggttg 2022061 gagaccgcgt tcctcacgac tggctgacct ggttaaaggg taaggatatc cccgtgtatg 2022121 tttggctgac cgaagaccca ttttatatgg atatcagcct tcaggtaatt aagcttgctg 2022181 acgccatatt aacgatagaa caaaatgcag ctctctacta tcaagagctc ggctaccaga 2022241 acgtctatta tgttccgata ccagttaacc atcggctgtt taaaaaaatg ggcaccgaac 2022301 attcctatca ttcaaatctg ttaatcatcg gctatcctta ccctaatcgg gttcagctta 2022361 tgaaagaagc ggtccatctg ccattcacgg ttcgggtaat cggcaaggaa tggggaaaat 2022421 atctgcctaa aaaagtgctc aaacagccgc atattgatgt cgtcagcaca tgggttccac 2022481 ccgaacaggc cgttcattat tataatgggg cagacatcgt aattaatgcg catcgtccct 2022541 atcattttgc tttcaaccaa aatactatgc gcatcaaaaa tgccagtttt aataaccgaa 2022601 cgtttgatat cgctgcatgc gaagcatttc aattaacaga tttacccgcg gcgcatcctt 2022661 tttcatccat tatttcttat cacggcatga acgactttaa ggaaaaagcc gctttctata 2022721 tcaaccaccc tgaagaacgg caaaaagctg cagcagccaa ttataaagag accgtacccg 2022781 catttacgtt tgatgagctt cctgcaaaac taaaagcgat tcatctggcg ctttcttgaa 2022841 aaatcgttca ttgctatgaa cgattttttt attcatagaa aaaagcagct gcacaagctg 2022901 ctttctattc tagccgtcag aacggtcttt cagcttcctc ggatttacct gtttatgaag 2022961 atcaggcatt tcgccgagat gctgtgcaat ttgttcccac gatacaattt tgaaattttg 2023021 attgacggct tgtccgttat caatattttc gccgtcctgc gccacaaaaa tcccgtacgg 2023081 atattttggg ccaagtccga aaccgagaac atcaatacca tccgtgtcac tagtaccgtc 2023141 tatcttctcg ccatctgtaa tctcaaagtt ggctacatag cgatttttcc cctgccgttc 2023201 atacattgca tagctgttat ttccttgact tgaagccatg agatatcctt tgccatttgg 2023261 tgcataatag attgtcagtc cttcaatatc agctgtcaaa tgatctcctg tcgcacggtc 2023321 aacaacctgc ccctttgacc ctccgccggg ctcagcgtta aatttccaga tggcctcatc 2023381 ttcctctgct atgtataggt ttccgtactc atcatccgca acaaggcctt cggtctgaga 2023441 attcaactta aattcacgca cctttttccc tgttacataa ccctttccac catcaacaat 2023501 ttcatactgc tcaaattccc cttgtttgcc tgtcactaat gcgtaaaatg ctcctgtttt 2023561 ctggctgtga tacaagctga atccataaac ctcagaaata ttggtggaaa taggatggtt 2023621 cggatctgta atgcttttca attttccttt atccccgtct attgcatata cttcaattgt 2023681 attttttcct tcggaccggt tggatgcggc agcaatatca attttttcgc cgttcaatgg 2023741 aaaatcatag cgcagatcga cattattgag cttgccaaac tcataagaat gaagctgttt 2023801 tccgtctaaa tcatacacaa cgagccctga cttcttattt gttgtaatca acttgctttt 2023861 ttccgggtgt ttttcatgaa cccaaatggc cgggtcatct gctgcatcat cgccagatgc 2023921 gaccggatct gtctccgtgt gtgcagtcac tttgaaatga tgttcctcat tcacataatg 2023981 agccgacacc gaggttgctg tcaggctaag caataaaccc gcggcagtgc ttagcagcat 2024041 tgtttttgga accttcattt ggtaccctcc tcttttatca ctaacactac tattgtaaaa 2024101 tatatacagg tgattaccgt gaggaaaatg aacctttttt tatagggttt ctgactcata 2024161 aacaacttat tccccaaaga ggtggtgaga tgactttgcc agatttactt ttgcggagcg 2024221 aaataaaaat atgttgaata tttagtacat tatttattta gttttgtttt tccctagtta 2024281 cgtccgtttt tccattttct attaaaaaag aacactttgt gacatgatca ttcccctaaa 2024341 ttttgtttta ttggttgctt tcattaattc gattacaaag ttgaacatat gatgcatggt 2024401 agagaaacga gagttggagg ataagccatg cctaaacagc aaacagcaga actaaaacca 2024461 tttttccata acaaaacagt tttagtcact ggcggaacgg gttcaatcgg gagtcaaatt 2024521 gtcaaacgcc ttttgatgct tacacctaaa caggtgattg tattcagcaa agacgacagt 2024581 aaacagtatg tcatgagcca aaagtatgcg gaggataagc ggctattatt tgtacttgga 2024641 gatgtacgcg atcacagaag ggtgaatcag gtgatgaaag gcgtcgatat cgtctttcac 2024701 gcggctgcgc tgaaacaggt tccgacatgt gaggaccatc catttgaagc gatccagacc 2024761 aatctcatcg gcggacaaaa tgtggtggaa gctgcccttt cacaccgagt gcagcatgtc 2024821 attaatatca gtacagataa agctgtatct cctgtgaaca caatgggtgc caccaagctg 2024881 ttatctgaaa agctgtttca tcaagcaaac cgccacgtcc aaaacaaagg aaccttgttt 2024941 tgttcggtcc gctttggaaa tgttctcggt tccagaggtt cggtcatccc catattattt 2025001 gaacagatga tggagggtga acctctgacc atcacagaca aaaacatgac cagatttttc 2025061 atgtcaatag acgatgcagc tacattgaca ttacaatcgg ctgctattac aaaaggcgga 2025121 gaaaccttta ttttcaaaat ggaatcactg aaacttgaag aactgattca tgggtttgaa 2025181 gaatatgcat cgcagcacgg gctcccgcgg ccggctgcag tagaagtggg caagcgtcca 2025241 ggtgaaaagc ttcacgaaga attaacatct ccacatgaaa ttgaatcact gtatgaatgg 2025301 ggcaaccttt atgcgatcct tccagagccg gaaaaacatc ctgactttcg caaagtcaat 2025361 ctgcctgggt atcaatcaga tcaagccccg ctcattacga aagaaagaat tgctcagatt 2025421 attgaagaat tgcatcaaga gaaaaaggca taaaaacaag cctgtctatc cattaggcag 2025481 gcctgttttt aacagtttat ttattaaaga gatgcagata gctttcgtat ccttcttctt 2025541 ttagcttatg cttcggaaca aaccgcagcg ctgctgaatt tatgcagtaa cgaagtccgt 2025601 ttggccccgg tccgtcatta aatacgtggc caagatgaga atcagcagtt cggcttctta 2025661 cttctgtgcg aatcatgccg tggctcgtgt ccagtttttc ttccacttct tcttcaatcg 2025721 gctttgtaaa gcttggccag ccgcattggg aatcaaattt atctttggat gtaaacaatg 2025781 gcttgcctga cacaatgtct acatacaacc cttcttcctt atgatcccaa tattcatttt 2025841 gaaatggcgg ctccgtgccg ttattttgcg ttacttcata ttgcatgcga tttaatgact 2025901 ttattttttc ttctttattg tacgccattt atttagcccc ccaatgctcg ctgataaatc 2025961 ccgctcgtcc ggaacctgtc cggtagcgct gataatgtgc tggattcttt ttataaaaat 2026021 gctgatggta gccttccgct tcatagaaag gttcagcttt taaaatgtcc gttacaatcg 2026081 gatctttaaa gatgccgctt tccgccagac gttgcttgga agcttccgca agctcctttt 2026141 gtttatcatt atgataaaaa atggctgcgc gataggaact gccgcgatca gcaaattgcc 2026201 ctccggcatc tgtcggatcg atttgctgcc aaaataattc aagcagtttt tcataaggga 2026261 atacatcagg atgaaacgtg atttgaacgg cttcacgatg tcccgtcgtt tcactgcaca 2026321 cctcttcgta cgtagggttt tcagtatggc cgcctgtata cccggacacc actttttcaa 2026381 ttcccggctg ttcgtcaaaa ggtttaacca tacaccaaaa acagcctcct gcaaatgtgg 2026441 cgatttcttt tttttcagac atactggtgc ctcctttgtt aatacgtggt attattatat 2026501 tatagcatgt aaaaatagaa tgaaaatgat tctgcttttc aataaaatct ataggtttta 2026561 agcaatatgc ttatgtaatg gaggttcaca aatttgaaag taagaacaca gatgatgtac 2026621 gatatggaaa ctttactccg taaagtcttt aaacaaatac gcaatgaaat caatgaaatt 2026681 ttagataaag agctgtcgcg gaatgaattc accattcttc gaatccttag tgaacaaggg 2026741 cctaaaaaag tcactgaatt tgcgcctatt ttagaggtat cggcaagcca cattacggct 2026801 gtgaccgatg cgctggtaga aaaggaatgg attacgagaa tcagatcgaa ggaagacaga 2026861 cgcatcatcc gcattcatat cactgaagcg ggcgaaaaag tccttcagca ctttaacgag 2026921 aaaaaaacgg aatatttctt taaacgcttt gactgctaca ctgatgctga acttgccacg 2026981 ttaatcgagc tcttcagcaa acttgataaa aaacggtgaa aaaaagcaca taccgatata 2027041 taggtatgtg cttttcgcag tgcttcactt atttttcagt aaacagcttc attgctttcc 2027101 agcggccata tctataatac aaaaatgccg cgcagctgct aaataaaaaa ctcattccga 2027161 ttccaagccc gattcctttt tgtccaagcc aagctgaaaa tagagctgtg aaaggatacc 2027221 tcaacaccca aaacgagatc aaatttaata ccagaacctg cagcatcgct cccgcggccc 2027281 tgacgattcc gttcagcaca aaattaaccc caataaaagg gtagaaaaac gcgatccact 2027341 tcaaatattg ttcaccaaat gcgaccgcat caggctcact gataaataac cttatgaggt 2027401 atttaccaaa tacccaaatc ataaccgcaa tcaccagcat gcaggaaata acagctatca 2027461 cacctagcct tgcaattgtt cccactcttt tttcgtttcc gattccaata ttttgccctg 2027521 ccatactatt gacggccgta ccggcagcca ttgctggaag cgtgatgatg ctatcaagcc 2027581 gctgcaccgc gccaaagcct gataccacgt gatccccgta tgagttaaca acactcataa 2027641 tcgccatcat accgcctgta atcaccatca tctgcagacc tgccggaatc ccgagtttca 2027701 aaatcagcgc ggactcttcc cacttgggca ttctcggaat cgagaatggc acaagcttgt 2027761 gtttgatgac ataaaacaac ccatacaaaa acgcaatgcc ctgtgacaaa atcgttgaat 2027821 aagccgctcc cgctattccc atgcggaaca cagaaataaa gagcggcgca agcactgtat 2027881 tcagtacaac agcaaacgca ataaaccgga gaggtgtctt gctgtcgccc agcgcacgaa 2027941 gcacagtact gataaagtta taaccaaaca aaaataaaat gccgataaat tgaatctgta 2028001 aatacgtctc agcaagcggt atcattgact ccggcgtttt tagaagacgc agcaaaagct 2028061 ctgagagaaa aaaaccggcc gcgccgaatc cgatgcttag gcctgttaat aaaacaacaa 2028121 aagcgttaat atacgacgcc attcctttta tatcatcttt tcctttttgc tgagataaaa 2028181 tggttaacgt cgcattgtta aggcccaaaa taaaagacag cacggtcaaa acaatcgtgc 2028241 ttgataccgc ggctgcccca agggcctttg cccccagtaa attgccgatc cacaagctgt 2028301 ctataaattg aaaggaaacc tgcaatgcgt ttccgagcat aataggcatt gaaaacagta 2028361 caagctgttt cagcacgttc ccctgtgtaa aatcgtatgc tttcatcttt tctccttgtg 2028421 ttctcaaatt ttcttcggac cacacgaaaa aagagacgtt gtttcatgtc tcttttttca 2028481 tgacttatcg gttttttttc ggtctcgcat accgaatgta aacaccatca cacttaggaa 2028541 caaggcacaa taggaaacat tcaaatacat ttgatccata tcttcagcag ccagatgatg 2028601 ataagcaagc cagccgaagt acagggaaaa tgtaaaggat aataaactga aatactggta 2028661 aatccgtttc attttcagtc acctctattg tttaggatgg taataggaaa actcaatttc 2028721 atctttttct aaatttatct tatccgcttt gacatacatt ccattcgtta aaggcatttc 2028781 tgacaaacgc acttcaatgc ttttatctcc ggggtgaaca tggacaaatg acggcaattc 2028841 ataaaagctg tccatataat ttaacacaaa gctaattggt atactcaatt tccctaacga 2028901 aaatttcgtg acattcagct ctacatcacc gttttttttc acggtcggct caaaagcgat 2028961 aaacgcatca atagacgtgg aaaatgcctt gattttccct gcgacatgaa catcatcatc 2029021 aatctctact ttataatcaa gcttgtttga tgctttgtcg tttaaatatg agttaacaaa 2029081 cgcagctaat gattcttttg tgcttgtcac ttgaaatcca tactcgctct cagatgcatc 2029141 tttcacctga gcctgttccc ccggaagcaa aacaagtgcc acaaacccgg cggcgaggat 2029201 aaaattgatt gcaagcaata taaaaaacag tcgcttccac ttattcatgc tgtcacccta 2029261 ctctttcggt aatccttctt ttttaatggc ttgatagacg cgctttgcga taagagaata 2029321 acccgtacca ttaggatgaa aatcatcttc ctcagaaatt cggctgctgt cacttttttg 2029381 attaaacaaa tcttcgatat ggacgatttt tgcatgttta tcttttttca gctctttttc 2029441 agcaatatgg ttccaatccg tgacgacacc atttatttca tttagttctg ataatgtaaa 2029501 cgtaaacgga ttgtacatgc tgacataaat cagctcagcg tgatcattca gctcgcgaat 2029561 ttcagaaatg attttttcaa agcgcttttc gtacggtttt tccgcttcct gaaacggttc 2029621 aacggttaat tgcagaaagt tttggcgaag gattttcatc aaatcattac cgccaattgt 2029681 aaaaaagaca taatctgcgt cctttatgcc tttttgaacc tttttatctt ttagtttttc 2029741 taataaatca tccgaacggt tcccttttac agcataattt ttcacgtcga ccgttttgac 2029801 ttgtttatct gaccggatag aatccgccac cttgccgaca tatccctttc cgtcgggatc 2029861 tccgactcct tctgtcagcg aatctccgac agccgctatg acaatgtgtt cttttgtttt 2029921 cgtttcatgg gctttttgtt ttccctcaga tgatgtacgt atgctcgtac acgcagtaag 2029981 aagcaaaatc aaactggcca tgattgaaaa aatgcgcagc ttcaatcttg ttgctccttc 2030041 ccattctact agtggaaagt gtatcatgtt ttagaagatt tgcaaatgcc tagtctctta 2030101 gcttacttga gtgtactggc tgacttcaca tcggaaatga tatcatcgta cggtgtattc 2030161 tccactccat tgtaatcttt cagcacctta ccgtccggac ctaccaaata aaaagaagat 2030221 tgatgaatca cttggtcctc tccctccggc ttctttacga tcgctttaaa gctcttaagt 2030281 gcgaactcct caatctcact ctggctgtat cccgtgagaa aatcccagtt atcaaaagat 2030341 aatggataat ttgcggcaaa tttcttcagc tgtttcggct tatcgttttc tggatcaaca 2030401 ctaaatgata tgatgcggac atctatattt tcggctttca gttttttttg cagatcggtc 2030461 atatgagcgg tcattggcgg acatatagtt tcacaattgg taaaaataaa atccgccagc 2030521 catacttctc cttttaaact ctctaaagaa acgttcttgc cgtcttggtt ttgaaatgta 2030581 aaaggctcca cctcgtaatt gagcggatct ttaatctgct gtcctccgca tgcacacaaa 2030641 aacagaaaaa tcagcccagc cgttaacccc ttgataacct tcatgacatc catcctttcc 2030701 agccagcata aaaacgcttt ctaaaaccgt ccttactgtc ccatgtttgt attcgatact 2030761 gagcaaaaaa aatcctgcat gcctccccat taacgattac aaaggagggc atgcaggtaa 2030821 aaaacggcat gttacgcgtt gtgctttaac acctcttgat gaaatacagc ctgataatct 2030881 gcccacttca tccgccgctt catataatgt cggaaagaat acacttttgc cctgctgttt 2030941 gatgaaaaca cttcttttaa gtagaattgc aaatggtgat gtaacataaa gaaatagtgc 2031001 tcatcttcct ttaatacagg tatttctgtc actttcacct gaatcccgtc accgcgtttg 2031061 aactctaggc ttttgagtaa caagctatca atcctctttt ttgtttttct tctattatat 2031121 atgatgccag ccgggctgtc tgtcattttg cgcggttgtg taaaaaaatt agattagcaa 2031181 atggaacaag tcctcatcct tgttcacctc tacataatga aacggttttt tgttcatccg 2031241 ttcaatcagc ggcccataat cggctttgtt ctgcagctcg atgccgacaa gagcaggtcc 2031301 attgctttta ttatttttct tcgtatattc aaaccttgta atgtcatcat tcggcccgag 2031361 gacttcgtca agaaattcgc ggagcgcccc cgctctttgt ggaaaattga cgataaaata 2031421 atgctgaagg ccttcaaaaa tcaaggaacg ctccttcatt tcctgcattc ttccgatatc 2031481 gttattgccc ccgcttacca cacacaccac gtttttccct ttaatttgat ccttgtacaa 2031541 atcaagcgct gcgacagaaa gagctccagc cggttcagca acaaccgcac attcgttata 2031601 taattcaaga atggatgtac atacttttcc ttcaggcaca aggagaatgt catcaacgac 2031661 agtttccagc gtccggaagg tttcctcgcc aattttttta acagccgccc catctacaaa 2031721 cttatcaatt ttatcaagtg tgacgacatg cccagctttg tttgattcaa agtaggatgc 2031781 cgctcccgcc ggctcaacag caattacctt tgtatcagga gacacgtttt tcaaatatgt 2031841 acctacccca gagagaaggc cgccgcctcc gacacttgca aaaagaaaat gcggttctgt 2031901 atcaatgtcg tttaaaatct cgactgcgag cgttccctgt ccggccatca catccggatc 2031961 atcgaacgga tggataaacg tccgagattc cgcctcacag cattcagcag cgcttttata 2032021 cgcgtcgtca aacgtatcgc ctgtcaaaat aatatcgata aatccttttc cgaatagttc 2032081 aacttgagat actttttgtc tcggtgtagt agacggcata aaaattttcc cgtgaatgcc 2032141 aagatgttta cacgaaaatg ccacaccttg agcgtggttt ccggcacttg cacacacaac 2032201 tccgttctct gtctgctcgc tggaaagctg tttcatttta tgataagccc ctctgagctt 2032261 aaaagatctg acaacttgca agtcttcgcg ttttaaatag atattgcatt catatctctc 2032321 agaaagtctg tcattcctct gcaaaggtgt gtgaatgaca acgtccttta cgttttggtg 2032381 agccttcaaa atgtctttca cttggatgag agagttttct ttaagcaacg gtttcatgta 2032441 cagattcctt tcttgtttta aatccctatt taatatgcca ttataacatg aatattcaaa 2032501 aaataagaca attattttta tttaataatt aaaaaaatac agactatgtc caccacatct 2032561 tgtggtaact tctgttcaac cattatcctg cagagccaag aaaaaagatg atcgtaaaat 2032621 aaagggtgtt ttcaaccaaa aggcatgata taatgaaacc aattagaacc aaaaggagcc 2032681 aattgatgaa tagtgcacca aaactcaata catttcaaca tctaatcgga gaacatcaaa 2032741 cttttctgga agcgaagcga atcgccaagc agttctcgtt atcggagctt cctgtcttaa 2032801 taacaggaaa aatcggaaca ggcaaaaatc acttcgcaca tgccatacac ttggaatctt 2032861 cgagaagcaa tgaaccgttt ataagcgtca attgcagcac ccattcggaa gaaaccctta 2032921 ttcatgagct ttttggccct aacggaaaca caggtgtttt tcaaaaagcg gtacgaggaa 2032981 ccctttttct tgatgatgta tggcgcatgc ctgcttctgt acaagctcag ctgttaaaag 2033041 cgcttgattc agacacggag aaaccgcgaa tgatctgtgc ttctgcagac cgatccgtgg 2033101 aacatacatt caggcaagac ttattctaca gactgaacat tttaacgctc acactgcccg 2033161 aattatcgga acgaaaaagc gatattccgc ttttgacaca gcattttctc tcaaattctg 2033221 gtcagcaatt gttaatcgat ccctccgttt ttcccgtgct tgagaagcat gcatttgaag 2033281 gcaatgtcag ggaattaaaa aacgctgcag attatatggc ggcagtatca agcgggggaa 2033341 cgattcagcc atatgacctg ccgccgtata ttagaggcac gatagacgga aaaacgtcga 2033401 agaaaaaagc gaaactgctt actttaatgg aaaaagctga gtttttgttt attttggaaa 2033461 caataaaagt attgaacgaa aaaggagaac ctgccagcag acggatcatt tctgaacaca 2033521 gcaaaaatac ccaaacctcg ttaactcctc agcaggtcag aagccgtctc gactatttgg 2033581 agaaaaaaga ttatgtcacc aaaagccgcg gacgcgcagg cacaaaaatt acctttgagg 2033641 gcttgagctt tatagagacg ttaaaaaatc aaatgatcta gcgatcgaaa ggagaatgta 2033701 cttgtttaca atcaaagaag agatcgccaa tgcgattaca cacggcatcg gtgtcctctt 2033761 atccatccca gcattagtgt ttctaatcat atttgcggct aattacgggt ctgcatggga 2033821 cattgtcagc tttacaatat tcggtgtctc tatgctgctg ttatatttga gctccaccct 2033881 gcttcacagc atcacacata aaaaaacgaa ggacattttg gagattattg atcatagcgc 2033941 aatttacgta ctcatcgccg gaacctacac gccttttttg cttgggccgc tgaaaggcac 2034001 actcggcttt accctgttgg ttatcgtatg gtcacttgcc ctaggcggaa tcgtttttaa 2034061 aattttcttt gtgaaacggt ttatcctatt gtcaaccttc gtgtatttag tcatggggtg 2034121 gctgatgatt attgcagtta aacctttata tgcttcactg agcggagcgg gattcagcct 2034181 cctttttctc ggcggcattt tatactctgt cggaaccatc ttttacattt ggaaaaagat 2034241 ccccttccat cacgccattt ggcacagctt tgtattgggc gggagcgctg ccatgttttt 2034301 ctgcgtgctc ttctattgtg taaaggtgcc tttcctttcg taacagtaac agaaaagcgc 2034361 agtcttcacg actgcgcttt tttatgcacg taattgtttt tcattggcag gtatataagc 2034421 ttttgaaaag gacaattcaa tgtctgccgg ttttaagcgt ttaaaaaacg agccattttg 2034481 catgttatct gttcctttcg tttccaccat caccaacgga agatgatagc gggccgcaag 2034541 ttctacagga tcaatagaac catctagtga aagaatcagg ctttgtccct tttccagctg 2034601 ttttgtcaca tcttcatata ccttttctga atccccgtct gaaatcacat ccatccgatc 2034661 cagccattgc ccgataaaag gcaagcggaa cacttttggg ttagcgataa agccggccgg 2034721 ttcctcaata tatccagcaa ttaaggccag ttcagccaaa cgcaaacggg gatgcacata 2034781 caaaacagga ccgtgtggta ttggctctgg ctgatggatc gtcacaactg aaccggagat 2034841 gccgatacag ccttctaaaa acgcctttgg ctgttcgtac acaagagcca tctgtttttt 2034901 gtatgacaga cggggatcga gcattgtttg attaaataat tgtttcatat tttttaacag 2034961 catatacaca atataaacca ctagaaggct gtagcgaacc aattaaaatc ctcccgcttt 2035021 agaagaattc tttttttcat acattagaaa ttcgtaatca tacgggtttt tttcgtcttt 2035081 ggtcccctgc tcagaagaaa ccagcttcca attggattca tcaaattcag gaaagtgacg 2035141 gtcaccctca aactcgtgat gaattttcgt catatacagt ctgtccgcat aagggaacag 2035201 gtccgtatag agctgagccc ctccgatcac aaagcattct tcagggcctg aacaaatgtc 2035261 cagtacatcc tttaatgaac tgacaaccgt gcatccctga aattctgaat ccggcgctga 2035321 ggtaacgaca atatttttcc gatttggaag cggacgtccg atcgattcaa atgttttccg 2035381 gcccataatg attgaatggc ccgatgttat tttcttaaag tatgcaagat cattgggcaa 2035441 atgccacggc aaatcattgt ctttgccgat aagcctgttg gcatccatcg caaaaatgaa 2035501 tgaaatcata cgctgaccgc cccttttata tgaggatgcg gatcataatc ctcgatgata 2035561 aagtcctcaa atgcaaagtt aaaaatagaa tcaacctttc tggcgaaacg aagctgcgga 2035621 agcggtctaa catctctttc cagctgcaaa ttgacttgtt caatatgatt ttggtaaata 2035681 tgaacatcac caaacgtatg gatgaactcg cccggttcaa gcccagtcac atgagcaatg 2035741 atcatggtta ggagggcata agatgcaata ttaaacggca cacctaagaa aacatcggca 2035801 gagcgctgat acagctgaca ggacagcttg ccgtcagaca catagaattg gaacaggcaa 2035861 tggcacggcg gcaacgccat tttatcaatt tcaccaacat tccaggcgct gacgattaag 2035921 cgtctggagt tcggatttgt tttaatatct tcaataagac gggaaatttg atcaatggtt 2035981 tctccatcag ctccccgcca agaacgccat tgggagccat atacaggtcc aagttcaccg 2036041 ttttcatcag cccactcatt ccagattcgc actccgtttt cctgcagata gcgtacattc 2036101 gtatctcctt ttaagaacca cagcagttca tgcgcaattg atttaaagtg gagtttttta 2036161 gtggtgagca tcggaaagcc ttcccgtaaa ttaaatctca tttgatatcc gaaagtgctg 2036221 attgttccgg tcccagtccg gtctcccttt ttctcaccat gctctaaaac atgtctgcag 2036281 aaatccttat actgtttcat ttttttcatc ctttaaaagt agtcttctag tagtgtaaca 2036341 caataaaaaa tcatttctga acccagaaat gattttttta tagtcagctg acgacaggct 2036401 tttcatcctg ttctttttct tcatcttgca gatcctgatg cgtatgtgca attctgctcg 2036461 ccgctgctgc agcaagagct gccacaatat catccaaaaa ggtgtgaata ccgtctggac 2036521 tttcatcaag ttccttaata attccaatct tctctttatc caaataaccg aaattggtca 2036581 aaccgatcga cccgtacaca ttaacgattg aaagcgggat aatttcatct atgccgtaaa 2036641 gcggttcatc cgtttcaaca aggtgctgca gcggttcggg gagaagtttc tgttctgcaa 2036701 gctgatcgag tgcaaggcct gtcaaaacag catgaataat ttcacgtttg ttcaggactt 2036761 tttctacatt ctccatgcaa acactgagcg gcagatttgg attgtatttt tcctgaagtt 2036821 tttgaacaat ccgtgcaata tcttctatca taacgccccg tttgttcagc atatcctttg 2036881 ttatatcgac catttcattc attgtgtact ttttcatgtc taatggcatc tcctttaggc 2036941 actcatccag ttgggaggcg tgttgcggtc ccagtaaatg ctcccaagct catgatgtga 2037001 ttgaaatcca tcttctgctg tatgataatg aaaattaaac cagtagccgt catgaggcgg 2037061 gtggtctctt cgcacatgga atctgagaag atcttctcca gttgtccgat tgtaaacgtt 2037121 gaaaattttt tccgttttgc ccgctgaagg catgcttgag atcacaacat cttggtacgc 2037181 ctcatcatct tgcaatgtcg ctaaataatc actaatcaca ttttcgattt ttggcaggat 2037241 ctctttccga tagtcatcct caatgacagg agcgattctg ctgccgaatt ttaaaaagga 2037301 ctgatcctca gcgctgtcaa ggagctgttc cttgtacgat tgaaaaagca gttcaggatc 2037361 tcgcctgtca tccgactcat catcgtacag gtcatgctca tcataaaaag cggtgtaatc 2037421 attctgctca agactgctcg gctgtccgga aggcttgtcc gccataaggg cagccggagg 2037481 agatacgagc ccgaacgtta caatggtaaa taaaaccaca agggtctttc tcatccacaa 2037541 tttcatgact gcttattcct ctctatttta ttgtcatgtt tctcttattt tagcacatcc 2037601 aaaacatgca agtcatgtac tatatgaaac tgatatgcaa attaggagat tcgttgctat 2037661 gcactttgtg taaaaacgct tacaatattt catgaaagga ggctttccgc atgattgacg 2037721 ctctgtttgc cacagtttca ctcttaacat tattatactt tgtcgtcatg gaggtcaccg 2037781 attaacagaa agcccgtgat atgaatcacg ggcttgtttg aatgacgcca taatggaaca 2037841 gtgctgtttt tcttttcatg acgttaaaac caaactgttc aaaccgcggg cttttccagt 2037901 ggtcttttag cacaacgctt tttctggcga ctcgtaccgc ttcattgata catccttcgt 2037961 gcaaaacgga atcctctgcc aaatcacgta aaggcgcgat gccgtcagag gtttctacag 2038021 gttcatgaaa cattggatcg aaataaacca catcaacaga gttgtcaggg agctgcttga 2038081 tgtgttcaaa gcaatcacca ttcttcacct ggattcttct catcgcagct tgaagctctt 2038141 ctatacccgt ttcccatgaa tgcagccccg tcctcactaa aacagacaca agatggtttt 2038201 tttcaatccc aacaacagaa cccgtttcgc ctactgccat acttgcgata atggcatctg 2038261 accccaaccc gagtgtgcaa tctaaaaacg tatccccttc agataagccg gcagcccgaa 2038321 gcataggttc tttctccccc tgtaagaagc gtttggctct gaacatcgct gtattcggat 2038381 gaaaaaagaa tttggcacct tgtttcgtat acagctcaaa ccgctctttg ccgaccacaa 2038441 gcaaatcacg ttcagctgat ttcagcaggt gctcaaccgt ttgtttattc cggccgcagt 2038501 atggcatatt tagctcttta gaaagctgct ttgcagtttt tatggtgtgt tcagacggtc 2038561 tatagcttgt tgttatcatc ttctgtactc ccaaaaagaa aatgcccgga gaacgggcat 2038621 ttagcagtgc gcatcgaagg cagcagtcag atttttcatg atttcttcca tatcgtgtcc 2038681 ttcaatttca tgacgcggaa taaaatgtac gacttctttg cctttcaaaa gagccattga 2038741 tggtgaagaa ggctcctggc cagtaaaata ctcacgcatt ttcgcagtag cttctttatc 2038801 ttggcccgca aatacagtca ccgtattgtc aggtgttttg tcattctgga ggactgcctg 2038861 tgtagccgca ggacgcgcaa ggcctgccgc gcagccgcat acagagttaa cgactacaag 2038921 agttgtgccc tctgcctttt ccataaagtt ttctacttct tccgctgttg ttaactcttc 2038981 aaaacctgct ccagtcagct cgcggcgcat cggtacgaca agctggcgca tgtattcttc 2039041 ataagccatt gacataaaaa aagccccctc tagtatcctt catctgaagt aaaggatact 2039101 atagagaggg ccggatttca aatgttcacg ccttaaaata aaagaaagtg tccccagcta 2039161 tctagatttt cataataccg ccggtgttgg cacttgtcac aagtttagaa taacgtgcca 2039221 ggtagccggt tttcactttc ggttcaaaac ctttccagtt cgcttttcgt ttttcccact 2039281 cttcttctgg cacttgtaca tccaagatgc gtttttcaat atcaacgata atatggtctc 2039341 cgttttcaac aaaggcaagc ggcccgccct cagcggcctc aggtgatacg tggccgattg 2039401 agaggccacg ggaggctccg gaaaaacgtc cgtccgtaat caatgccact tttggcccga 2039461 gtcccattcc aacgatttgg gatgttggcg ccagcatttc cggcatgcca ggtccgcctt 2039521 ttggcccttc gtatctgatg atgacaacgt cgccttcttt tacttttcgg ttgataatgc 2039581 cgtcaagcgc ctcgtcctga gaatcgaata cgacagccgg cccttcgtgt cttgtaatcc 2039641 cattctgtac gccgcctgtt ttaatgatag cgccgtccgg agctagatta ccgaataaaa 2039701 cagcaaggcc tcccttttca gtgaatggtt gatccagcgg gtgaatgacg tcataatcct 2039761 ttacttcatg tccggcaatg gtttctccaa gagtttttcc tgtaacagtc agcgcatcta 2039821 aatgaagcgc tccttctttc ttcgaaagct cattcagagc cgctgaaacg ccgcccgctt 2039881 cgtgaagatc ttcaataaac acatccgatg caggcgccag cttagccaag tgcggcacgc 2039941 gctcagcgac ttcgttaatg cgttctaaag agtattcaac gccggcttcg tttgcaaggg 2040001 caagggtatg aagaacggta tttgtagaac ctccgagcgc catatcgagt gcaaacgcgt 2040061 tatcaatcgc ttttactgta acaatatcac gcggtttgat atctttgcga atcgtttcca 2040121 ttaattgcgc agccgatttt ctcacaaact ctttgcgttc cggagatgtt gccagaatgg 2040181 ttccattacc cggcaaagca agaccaagtg cttctgacag acagttcatt gagttcgccg 2040241 taaacatgcc tgagcaagac ccgcacgttg ggcatccgaa ctgctctagt tcttgaagct 2040301 cgttttcgtt gattttccct gcttggtagg cgcctacccc ttcgaatact gaggaaaggg 2040361 agatttttcg cccgtcactt gttcttcctg ccgccatcgg tccgccgctg acaaaaatcg 2040421 tcggaatgtt gatgcgcatt gccgccataa gcattcccgg tgtgattttg tcgcagttcg 2040481 gaatacagac cattccgtca aaccagtgtg cggatacaac cgtttccaca gagtctgcga 2040541 taatttcacg gcttggcagc gaatatctca taccgatatg ccccattgcg atgccatcat 2040601 ctaccccaat ggtattaaat tcaaacggaa cgccccctgc ttctctgatt gcttctttta 2040661 cgattttccc aaactcctgc aagtgaacat gaccgggaac gatatcaatg tatgaattac 2040721 acaccgcaat aaacggcttg ccgaaatcct cttcttttac ccctgctgca cgaagcaaac 2040781 tgcggtgcgg agctctatcg attccttgtg tgatcatatt actgcgtaat tctgccatgg 2040841 tgatcctcct aaattctttc aattgtttga ttggatttta ttttgacaat tttcagttta 2040901 tttatgggct gtttttgcaa ataagataaa tacaggccgc cctcaccttg ttttgttctt 2040961 tcgtgttttt atatttatat agctttcttt cgatttgaac cctccaacta ttaatattgt 2041021 tacttactat aaatagtttt cggatatttt tcaacaatat tcgaaataat ttttataaaa 2041081 agtgaattca cataaaaaag gtgcatgatc tgcacctttt ttatctttat tcgccttttt 2041141 ttctgctttc cgtcatttgt ttccaaacag aaccttttgc ttcttctcca tgctcaatac 2041201 gttcaagcgc cattttgact tgaaggctga cctcaaattc ggggtcatct tcggcagcgc 2041261 gcaaagcttc aattgcactt tcatcgccga cttcgtacag gaacatggcg gcacgccagc 2041321 gaacaagctt gctggagtcg cttaatgact tgatcatagc aggaatggct tgaggatcgc 2041381 cgatatcaga caggcagtct ccggccgttc ttctgactga tacagctttg tcctcaagtg 2041441 ctttatacaa tagaggaaga acatcaggtg tttcaatcat tcctaagtac acaacagcct 2041501 gtcttctgat ggacaccttt ggatcatcca atgccttctg taaaaccggg atatcctctt 2041561 ctttcggatc catctgttcc aagtgtgcat aacgcttttt ccagtcctca tcatccagca 2041621 tatcaagcgt tactttatac gctttgcgct gtacagcttg ttttgcttcg ccctttcctt 2041681 gagcggctgc ttcagtcagt cgtttcagcc gttcatcact gtatgccgct tgaagctctt 2041741 ctgtcacatc atggccgatt tcatcaaagt caccgaatct gacaccttgt tctttccaag 2041801 cccgctcaaa cacaacattg gaagcttcag atctaagttt taagatcgcc tgctgaaagc 2041861 gttcaggtaa gccgaagcgt tcttcccgct ctccatcggt taatttaact tgcataggaa 2041921 tgccgctgaa catctgcaca aaaactttta cctctccaaa agattcttga tcagaacgat 2041981 tttcttctgc gctttcagca ctttccatcc caaatgcagt gcggacttgc ggtaaaatgt 2042041 ctttccagtc gtatcttgca ttccgttcaa cagcaagaaa atctgcgacg tgatataccc 2042101 ctttaactcc atctatttta aggatttccg ctataacaag cggtgcgcct tctgcttgct 2042161 caggtttata gttattgctt ttgcccgccg gaagctcttc cgttaagatg actttcattg 2042221 tattcgggct tggtgtaggt tcaattgatt ttatcttcat gatcgtcctc ctatagcata 2042281 tctgtgactt attctatcat agtcgctcca agccttctat tacgacgttt cggcatcaat 2042341 cccgggtatg tctttttcta attggcggac aaattgaagc ataaaattgt gtctttcttc 2042401 tgccagttcc cgtgcagtgt ctgtattcat catatctttc agccgcagca gcttatgaaa 2042461 aaaatgagcg taggcgcttt gctcatctcc ataaaggcca tgcccttttg cgcccgcaaa 2042521 catgaaagct ctcgcaatgc cgacagcacc aatcgcatca agtctgtcag catcctgtac 2042581 agcttttcct tcaattgaga gcggctcctt cgccaatttc cccctgtccc gaaaggacat 2042641 ccttgttata atatgaatca ccctgtcagc attctctttt cctactccga aaaaaacgag 2042701 ctgatcatat acttcgctca cagaaagcct gaccgtgtca ggcagcttca catcaattaa 2042761 atcatgaacc aaagccgccg tttcaacaat gaacaaatcc gctttttcct tttctccaat 2042821 atacgctgca agatctgcta ctcttgatac atgatgccag tcatgtccag agctttcgtc 2042881 agtcaggata gattgaaccc atgtcctgat ttgctctgcc tgcttcaatt ccttcacaaa 2042941 aacaccctct ttttattgct ctaatagctt cacgatatcg tcttccaact ctttcggatt 2043001 tgtatttggt gaataacggc caacgatttc tccatttcta tccactataa atttcgtgaa 2043061 attccacttg atcgccttag ttcccagcat ccctttcgca tgttctgtca aatacacaaa 2043121 cagcgggtgg gcgtttttcc cgtttacatc cacttttgaa aacataggaa atgtaacacc 2043181 gtaatttgtt tcacaaaatt cctgtatgtc agcctcttca ccaggctctt ggttcatgaa 2043241 ttgattgcag gggaacccta agatctccag cccctcctgc tgatatgtat catataattc 2043301 ctgcagctgc ttcaattggg aagtaaaacc gcacttactt gctgtattca cgatcatcag 2043361 tacctttccc gcgaaaggct gaagtgtcat gtctttccct gtgattgtac gtaccttcat 2043421 atgataaata gacatgtaag tccctcctat gtccttggtg ctgattattt tacctttttt 2043481 aaatcgcaat tcaaaatgta aacatcaatt aagaactcat aagaaaccta acgatatgag 2043541 cgtcagttca ttatcaattc atatggctcg ttttttatct tatcattcta taaaacatta 2043601 caattccctc ttacatcttt gaaaatcatt ttactgtgaa accaaaaggc gtgtcagtgc 2043661 gttttattta aagagttttc tgttgtttcc ccctcaacac gtatagatag attgaaaatt 2043721 ggcgtgaaaa ttcctataat gaagaaaatt aaacggggaa ataatggagg tggcacgttg 2043781 cctattaata taccaacaca cctgccggca aaacaggtgc ttgaaagtga acatatattt 2043841 gtaatggatg aaagcagagc atttcatcag gatatccggc cgcaaaaaat tattatatta 2043901 aatttgatgc cgaaaaaaat ccaaacagag actcagcttc tcagattgct tggaaattcg 2043961 cctttacagg ttcatttcac atttttaatc ccaagcacac acacgccgaa aaatactgcg 2044021 agagaacacc ttgacgaatt ttacacgact ttttccaata tccgtcacaa gaggtttgac 2044081 ggcatgatta tcaccggtgc gccgatcgag catttggcgt ttgaagaggt ttcatattgg 2044141 gaagagctca aggaaatcat ggagtggagc aaaacaaatg tcacttcaac cttgcatatt 2044201 tgctggggtg ctcaagcagg tttgtattac cattacggtg tggaaaaaat tcaaatgccg 2044261 aaaaaaatct tcggtgtgtt cgaacatacc gttctttcaa aacacgaaag attggtaaga 2044321 ggttttgacg agctatacta cgtgccgcat tcccggcata cagatataaa tatggaacag 2044381 cttcaagcag tgcccgagtt aaacattctt accgcatcaa aggaagccgg ggtttgctta 2044441 attgtgtcta aagacgaaaa acaagtcttt ttgacagggc accctgaata tgatacaaat 2044501 acgcttcttc aagagtatga aagagatttg gaacgaaacc tttctactgt cgaggcccct 2044561 aaacattatt ttgcaaaagg cagcaacgag ccagtgaatc gctggaaagc gcatgccaca 2044621 ttattgttta tgaattggct gaattattac gtttaccaag aaactcctta tgaatgggac 2044681 taatttttct ttttttagtg atacgctgag caaaaaatat gataaaatac atctgattca 2044741 gtctgcgtat aacaaaaatt taaaatactg gaatccaaat catttaaaat tagcttaact 2044801 ttttcactgc attaataatt cgattatgta tttgtgttat gtttatgtat agacaataac 2044861 tccttacgat gcatgaagct tgcttgttgt tgattacatt gaggtgaatt tacttgaata 2044921 ccaataaaag agtattaatt ttgactgcaa attacggaaa tggacatgtg caggtagcca 2044981 aaacacttta tgaacaatgt gtacggctcg gctttcagca tgtaacagtt tctaatttgt 2045041 accaagagtc aaatccgatt gtttcagagg taactcaata cctttattta aaaagcttct 2045101 caatcgggaa acagttttat cgtttgtttt attacggagt tgacaaaatc tataataaac 2045161 gtaaattcaa tatttacttt aaaatgggta ataaaagatt gggcgaactt gtcgatgaac 2045221 atcagcccga tattattatt aatacatttc cgatgatcgt cgtgccggaa tacagacgcc 2045281 gaactggaag agtcattcct accttcaacg ttatgactga tttttgtctt cataaaattt 2045341 gggttcacga aaacgtggat aaatattatg tggcgacaga ttacgtgaag gaaaaactgc 2045401 tggagatcgg cactcatcca agcaatgtaa aaatcacagg aattccaatc aggccgcaat 2045461 ttgaagaatc catgcctgtt ggcccgatat ataaaaagta caatctttca ccaaacaaaa 2045521 aagtgcttct gatcatggca ggtgctcacg gtgtattaaa gaacgtaaaa gagctgtgcg 2045581 aaaaccttgt caaggatgac caagtgcaag tagttgtcgt gtgcgggaaa aatacggctt 2045641 taaaagaatc tttgagtgcg cttgaagcgg aaaatggtga caaattaaaa gttctgggct 2045701 atgtggagcg cattgatgag ctatttcgga tcacagattg catgattacc aagcccggcg 2045761 gcattacttt gacagaagcc acagccattg gagtgcctgt cattctgtac aaacccgtgc 2045821 ctggccagga aaaagaaaat gcaaacttct ttgaagaccg cggagctgcc atcgttgtga 2045881 accgtcatga agagattctc gagtcagtca cttcccttct tgcagatgaa gataccttgc 2045941 atcgcatgaa gaaaaacatt aaggaccttc atttagcaaa ctcctctgaa gtgattttag 2046001 aggatatcct gaaggaatca gaaatgatga ccgccaaaca aaaagccaaa gtgctatcgt 2046061 aatggcgtac ttgagagcat acgaaaatcg tgtgctcttt ttatttatat tcagccatca 2046121 ataaaagcgg ttacattttt ttatggaact tgcccttctt ttgaaaaata agccgtttcg 2046181 caacttgacg ggtgctccca gatggtgtat agttgaacca tcatttaaca atgaatcaaa 2046241 gttagatgat gacaaaattt tttttagcac atgggtgcta cagtactagg aggaattaag 2046301 caatatgcaa aacggtaaag taaaatggtt caacaacgaa aaaggattcg gcttcattga 2046361 agttgaaggc ggagacgatg tatttgttca cttcacagct atcgaaggag atggatacaa 2046421 atcattagaa gaaggacaag aagtttcttt tgaaattgtc gaaggtaatc gtggacctca 2046481 agcttctaat gttgtaaaac tctaaactca atacatgatg atgagatgac aaatagagga 2046541 gaggcattcg cctctcctat ttgattttca tctggatttc aatcgccaaa atgttttgtt 2046601 tacacctctg ttcaatctct tcaacatact tttccattga tggttttcct tttttcgcga 2046661 tatcggccag ttcttctaaa tcactgtata tttctataaa tgttttgtga aggatcaact 2046721 tcaagtcttt atcatccata gctgcgttcc ccttctctat caagatacct caaatagtaa 2046781 aacggtccta tttattctgg ttcaatagtt atatcggctt atttttattt tcttttctat 2046841 tttggtacat aaatttcaaa aaaactctgc aaaataatgg cggaggtgtt ttttgtgact 2046901 tcagaatttc ataatgagga tcagaccggc tttacggata agcggcagct ggaactagcg 2046961 gtggaaacag cgcagaaaac aacaggagcc gcgacgagag gccaaagcaa aacattagtc 2047021 gactctgcat accaagccat tgaggatgct agagaactgt cacaatctga agagctggca 2047081 gctctcgatg atcctgaatt tgtaaagcag caacagcagc tgctagatga cagcgagcat 2047141 cagctggatg aattcaaaga ataaaaaccg cagcttctgc ggtttttatt tttagtgatt 2047201 ggttaagaca tctccgtatt gtttcaactt ttcaccaacc gtacatttat tgatacaaaa 2047261 tgaatgcgca taagttttgc caaattcttt gcgaaactgc ttcttaataa aacagtcctt 2047321 gcaatattca tcgtgcagtt ctgtcagttc tttaaagatc attttcttat ccaatatcgt 2047381 catctccgtt acggtctaat ttcgtgtggc tttctacgaa ttgatgggat agaatttttt 2047441 tagcgaggcc gtcagcttcc tgattgtctt ttcgttgtat tgtttcgtag gttggagtaa 2047501 gcttcagcga ttcaaggagt gcttctattt tgtccagcca ttcattatga gatggatcat 2047561 aacaaggcca gctgccgtca agctgattca gcacaacaag cgagtcccct ttgattgtaa 2047621 ttgaatttct gcttgcccca agctctctta cttctcttat tgcttcataa agcgctgcgt 2047681 attcagcttc attattggtt ttcagccgga agcttttatt ttttctcaag cgatgccggg 2047741 ttcctcccaa tgaataatag atgacgatcc cgagaccggc cagttcgctc tctttatcga 2047801 aactgccgtc aaaataaaca gtaatgtcat caggctcttg agcaagctcc tctgtcagct 2047861 tttccaattc cttcagcgtc cagctgccgc ctttctcgtc ttcgaactct agctccttca 2047921 tgtatggaaa acggccaagt tctctggcga acgtacgtgc ctgctgtgct gtcagccagt 2047981 cttcgctaaa aaatgagacg gatcccgttc cttttgcttc tattttcaaa tgcggtctga 2048041 gcttcattac aatcacctta ccattcatta gttgccgggc ttatgctata atcaaaccaa 2048101 tcttaccccg gaaaggaagc tttttcatct tgtttaataa ttcgttttgg atcttttttg 2048161 cgatcattca ttttatcatt gttcttttat tttataaagg atttggcaaa atgggactgt 2048221 ttgtttggat cggttttgcg acagtctgcg ccaacctcca agtcgtcaaa acagtcgaac 2048281 tgtttggctt aacagcgaca ctcgggaatg tgatgtatgg cacaatcttt tttgcgacag 2048341 atgtgctgaa tgaaaaatac ggaccagctg aagccagaaa agcggtatgg ctcggattct 2048401 caacgctcct gacgctgaca tttgtcatgc agggcgtgct gcttttcgaa ccggcttcca 2048461 gcgacatatc acaaacagcg ctggaaacga tcttcggatt ccttccgcga gttgcgttag 2048521 gaagtctgct tgcctttatc ttcagccaaa cgctggatgt ttatgtatat tcggcaatta 2048581 gaaggatatt tccttctgat cggcttttat ggctcagaaa cggcggcagt acagcagtca 2048641 gccagttgtt tgatacattc atattcactg cagtcgcctt tctcggcatt tatccggcag 2048701 acgtgtggct tcatattttt atttctacat atttgattaa gtttgcggta tctttaattt 2048761 cattgcctta tgcctatgca gccaaaaaaa tgatacctaa tgatgaaagg agttcataat 2048821 gcctacagaa atatatgtag acggcgcaag cgccggtaat ccagggcctt ccggtatcgg 2048881 catttttatc aaacatgagg gaaaagcaga atctttctct attccaatcg gagtgcatac 2048941 aaaccaggaa gcggaatttc ttgcattaat tgaagggatg aagctatgtg caacgcgcgg 2049001 gtatcaatca gtttcctttc gaaccgattc agatattgtg gaacgcgcca ctgagcttga 2049061 aatggttaaa aatataacgt ttcaaccgtt tgtagaagag atcatccgat taaaagcggc 2049121 attccctctt tttttcatca aatggatacc gggcaagcaa aaccaaaaag ccgatcttct 2049181 ggcaaaagaa gcgattcggc tgaatgaaaa gaattaaatc ttgatcattg gttcatccta 2049241 atggcgaggt gaactaacat gaaaaagaaa gataaaggcc ggctgaccgg cggtgttact 2049301 ccgcaaggcg acctggaagg caatacacat aatgacccta aaacagagct tgaggagaga 2049361 gcaaaaaaaa gcaatacaaa acgctagaga ggatctaaac gatctctcta gcgttcagct 2049421 tttcaagcat acgctcaatt cctttaattt ggtggcggcg aagcatgtca gccgcctgct 2049481 ccatttgcaa agtaaataaa gcgtctttca gtgtgcaggc cagcggcact gagcaatgga 2049541 tttccgcaag cttcctcgac atctccaaat cgcttaaacc ttgctgaatt tttccctgct 2049601 gtccttttgg aagaagagaa agattttcca ataaacggtc aatcgtttcg tattcacgaa 2049661 tcagtttgta ggctgttttt tctccaatgc ctttgactcc gggatagtta tcactggaat 2049721 cacccataag cgctttaata tcaatcaaag ccttcggcat tacgcctgtt tcttcataaa 2049781 aagtctcttt tgtatagact ttataatttc cgattccttt ttgaagcaaa gcaacgctta 2049841 ctttatccgt taacagctga agtaaatctc tgtcccctgt taccaccgta atgtccgctt 2049901 cattcgcaaa taaatcggca agagtaccga tacagtcatc cgcttcatag ccggcaaagc 2049961 caatattcat gattccaagc tctgcggctg cttcctttgc caaatcaaac tgcggaatca 2050021 gctccacagg cggcgcgctg cggttggcct tataatcttg gaacaagtca tttcggtacg 2050081 ttttgctccc catgtcccag cagcagacga cgtgtgtcgg ctggaatgtt tccacagctg 2050141 taatcaaatg ctttaaaaag ccgttgacgc cgttcgtcgg caccccgctg tcatttatca 2050201 taaagttgcg atgtacggcc gtggcaaaaa aggcccggaa taaaagagcc atgccgtcaa 2050261 ccagcaatag tttattatta ttcatcaaat aactcccttt tctttcattc cttctatttt 2050321 atcataaagc agcccaaaaa taaaaaacag tatctcttta attagagata ctgtttgaat 2050381 atttatcaat cgttgtgtct tttgttgctg gcgatcagct tttcagcttc gcgtcctgcg 2050441 taagagtcaa aatgggtttg aaatccgttt ttctttttgg cgttgttatt cgcctgtgca 2050501 tttctgtttc cgagctttgt tctgcccaac atgaatcccc ccttacgtcg gatgcatata 2050561 gtatatgctt ccggcaggag gttcactcgc gacaggatca tccagcttac atgcggctta 2050621 cgtattctct gaccatttct tttgatacaa gccgtcttgt cgggacgatg ccttttttag 2050681 cgagctgatt catttgctcg gtaatttcat taattgcatc tgtagtataa ggctcatcgt 2050741 ttctgcattt agcaacagct tcttcaatcg ccaattcacg catattttca agacgcataa 2050801 atgctttgat atgctcgtgc tgttttgatg aatgtgctga aattgcttta tgtacctctg 2050861 acattaatcg ttcatctcgc ttttttctat ttagtctatc atgacttgaa atacaagcca 2050921 actgaatttt acatttttat tgtattgtct gaatttttcc aggagatgca cgcctgatac 2050981 gccatttcaa tctctttcgc atgttcccct tccgcatatc ctcttaaata tgtctctttt 2051041 tgatccgtta tttgcgcgat tgctttttca cccatatctt cctgtaagcg tctgaggtga 2051101 gcagtgtaat gagatatcag gctttcttct tcatttttta tccatgcctc tgtgattttc 2051161 gtaagtttca tccgtacagc ttcgataaag gtcgcttttc ctttctgctc aaaaaactgc 2051221 ttcggtgatt tgatctcttt tagttcctgc tcaaaagcac gttcttctat ttccggttca 2051281 acttccttca actgtatgcc gttcgaatgc tgatcacccg cataaacgga aaaataaccg 2051341 tcctcgttta atgttttttg aaaatgatcc agccattctt cattgatatg ccgttcgatg 2051401 aaaccgctca tgcgaacatc aagcgttttg atttcctgaa tatattcaaa tagatattca 2051461 tgtaaggctg ttgtcatcgc tttactgacg ttctttttcc aatccccgtt ttgcagcccg 2051521 ggatgaaatg ccgattttaa taaatcattt gcaaaatatg ataatcgctg tgcaatgtga 2051581 tatagctgct ctcttgtatc tttttttact ttttcaatga tggtttttga gttccgccgt 2051641 ttctcgatat cggccgctgt ccgctcaaat gacagcataa ggcactgttt ctgcgcttcc 2051701 ttctcttctc gggactgatg ctgggattgg tgaagctgaa aaacagtttc gcatagtttg 2051761 tctgcctccg aactgagctg cgctgctgac gcttttttta catccacttc gataaaccgg 2051821 tctaagtgtt ttcttacttt cgagaactga ttataaaatg actccggttt tcccaccagt 2051881 tcctccttac ttgatacggt aaagagctgc ggctcataaa ccccttcttt tacaagctct 2051941 gcgctgacat aatcggtcac tgtttcgagc tctgttttat cttttgcaag gtctgcagca 2052001 ttaataataa aaaacatttt atccatgctg agcgattctt tcacaagtcc aagctttcgc 2052061 aaaaatgaac ggtctccttt tgaaaaagag tgctgataat aagtcatata aaaaaatgca 2052121 tcagcatctt tgatatattg gaatgccagt tctgtatgcc gtttattcat gctgctcgcg 2052181 ccgggtgtat caacgatcgt aatccctttt tcagtgagcg ggcatgtata gtagaccgtt 2052241 acctctttca cagcacaggc cgttgtttcc tctgctacat acggctttaa ttcagagagc 2052301 ggaatcgtta atttcttctg ttcctgtata tactgctgat acttctcgta tgcaagcagg 2052361 aaattgctga tcaatttcac gtgttcttcc tgcagcctgt tttttttgac tgccttttcc 2052421 cacttctctg tgaaggaacg gcctgccggc tcctttggta ttccggtgag ctgcaaaatt 2052481 tcagccgtta agtcatcctc tgtcttaaac actacattcg ctgttttgtt taagttgcca 2052541 ttgattggct ttgtgatctt gttaattgtc gctgtggttg gcgttggtga ggatggcagc 2052601 actctttcgc cgacaagcgc attggcaaat gatgatttcc ccgagctaaa gcctccaaaa 2052661 agagcgagtg taaatttccg ttcctcaagc cttttcaccc tttcacgaaa cgctgaagtt 2052721 tgctttaaca acatgctgca ttcgcctaaa atgtcagaca aagtgtaaaa gcgtttgatt 2052781 tggtcttgaa gcggcatttc ttgttccatt ttgatttctg atttcggcat cggctgcgcc 2052841 gtcagctggc ttcggccttg tttctgctct ggagccgcca ctcttgtttt cttcgattta 2052901 aaccattctg tgtctatatg cattgggcat gcggactctt cttcccaaat ggcccacagg 2052961 cgatcggttt tctctcgggc attattctct aaacgtgcct gttcttgaag aaagacaagt 2053021 ttttctgatt cttggacgag ccggtcgtta attgtttgca catctttgga aacacgctct 2053081 ttcaccatag cggagagcac ctttatgatg tctgcggctt ctcttttcgc ctctttccgg 2053141 atgagctctg ccaagtcttt tgtatattgc aatacatatt cagaggaaaa ggctgcacca 2053201 tgcttgaccg cgtgttcaat gatgcttata tcaagcggtg tgcgataggc ctgaatcagc 2053261 ttttcacttt cagcggtata gacatcaaat accttggcga gtttatgaag cgtgtctatc 2053321 atatgccaat ccgcttcggc ctctgttcgt tttgccacat cagagaaaaa agcattccgc 2053381 cttttatctc tttcctgtgc agttttcgct ttagaaaaga aaaagccggt tttaaaggaa 2053441 ggctcttgtg attctaaaaa tgcagccgcc aattcacgca tttcaaaagg cgtcaggttg 2053501 gcgtttttta aaatacgatt gatttcttcc tgcatcctct tctctgcctc agtcatttgt 2053561 ttttcggcct catccaattg atcacgcagc gattggacca gtccagtatg gatattaagc 2053621 tgttcagcga aactcggagc gcctgtttcg tctttcttca gcatttccgt atgttccttt 2053681 agcagattac ggactttttg ttcggttaaa gcctgcatat tgctttttga ttgctgttct 2053741 attctgctta actcttctct cagggccccc atctgattga acgggtgatc cggttctgtt 2053801 actgatgtaa aatagagcgc ttcccttgaa atcccttcat tgcaaagcat ctcctctacc 2053861 tgcgcttgat agtctccaaa tttcgtctcc gtctcatcat ggcggtcaat ttgattgacg 2053921 ataaaataca cattcggaat gctttctttt attgatctga gaaactttac attttcctca 2053981 gcgtgcacgt gattatagtg aacgacgtaa aacagcgcat ccgcttggtg aagaatagaa 2054041 gcagccgata gaaaatgcgc atcatctgtt gaatctatcc ctggagtatc aatatacgca 2054101 accccggaat cgatctcagt atacctgtca aaaatttcga cgctttcaat ctgttccccg 2054161 tctttacaat attgctgcac cttgtctttc tggtaagtcc cttccagctc agcacacgct 2054221 ccgtctgttg tatgaagccg aactcgcttt tccccgtttc tgatcacaac aaggttagcg 2054281 cttgtcggaa tcgggcttgt cggcaaaata ttctccatta acaggcagtt cagcagtgac 2054341 gatttccccg ctgaataatg cccggtaaac gcgatataaa cctcttcatc agccgctttt 2054401 ttcatgaccg cagccagttt agcagccctt tgttcatctt gattctcaat aaattgctta 2054461 taaagttccc cggttttatg caaaagctct tttctgtttt gatctgtcat aagtctgaac 2054521 ccctttgtgc cgtttcaatt gtgaaccttt ttcgaaagat ctgaattcat tcccttttca 2054581 ttttacacaa gaataaacca aatttcttta ggagaataga aaaaagccgc cattacggca 2054641 gcttctataa aagaaaatct gcaactttta caagttccag attcatcaaa cagatttatt 2054701 agagattcct tttaatacaa aaccaattaa tacactatat gtacaaaccg ctccaagcaa 2054761 aaacagcatt gtcatttgct tcaccatcct gattgagaat ctttttcaaa cccattttaa 2054821 catggttgag aatgattttc aatcgctatt ttacgctgta ttcctgtaat gctttgtctt 2054881 ctgcgcgaat tctgacgctt aacaacacgg cattgaaaat ggaaaacaga cacatggtga 2054941 cgtatgcttg ataaagcagc ggaatcagca aaatttcgag gataacaacg gcatagtttg 2055001 gatgtttcat ccatttatat ggaccttttt ttacaagctc tacacctgga acaacaagga 2055061 ttttcgtatt ccaatatgct cctaaggaac aaagcgccca ataccgtacg atctgtacgc 2055121 ttaaaatcac tgcagcgata ccgagccacc agctggacgg ctgtttattc atcagcagca 2055181 cctcggcaat taaggacagg aaaaaaagga tatgcatcgt aatgatatac ggatagtggc 2055241 tctcgccaaa ttcaattgct ccttgcttct ttaccttttg ttcgttttgc ctggccactg 2055301 ccatttctgc tgctctttga acaatgagaa tggcgatcaa caaccaaaac atgagtcagg 2055361 cccccttttc ccagctgaat aatagcaact ctgatgagaa acccggccct aatgcgccaa 2055421 tcagtcctcg ttcagcttcc tttttatgtc cgttctgcag atggtctttg atcacataca 2055481 agattgtggc tgaagacata tttccgtgct tttgcaaaat gctttgcgca gatgaaagct 2055541 tttctgacga cagcccgaga cttttgatgt atgcatcgat cacttttttt ccgcctggat 2055601 gcgccaaaaa aacactgata tcatggaatg acagcttatg tttgtccaaa aaaatctgta 2055661 catttgtttt gagccatttt tccaccaagg tcggaatgtc tcgtgagaaa atgactttga 2055721 atccttgatc ggtaaagtcc cagcccatga catcttctga ttgtttcatc aaaacagatt 2055781 gggcgtccat tatcttcggc gcaagcttca gctttgacac cctgcggtcc gccttctctc 2055841 cgcataataa agctgcggca atgccgtcac caaaaagcga ggtgccgatc agattgcttt 2055901 ttgttttatc ttccggctgg aatgtcaggc tgcacagctc ggcagaaatg acaagcacaa 2055961 aagcctcagg atacgctttg cagtattcgg ctgcacgcgc aagtccgctg gctcctcctg 2056021 cacagccaag cccccaaatc ggaatccgct tcgtatatgg agaaaacgga agttcattca 2056081 taagccgcgc ctcgatactc ggtgtggaaa gacctgtact ggagacgaaa aaaacagctt 2056141 ccactttctc ataaggaatg gcttcttgaa aaaattccgg atgagagagg cactcacgaa 2056201 cagccgctct gctgtgttta agtgtttctt ctatgtatat ttgatttttt tcttcaaagc 2056261 tgtgcccctc tttataccat tcaatcggct taacaaactg tctcgaatgg atttgcccgt 2056321 ttttaaagga ggataacagc ctgtcaatat ccttaaaaga atgctgaaac atatagcggg 2056381 cgaactcggc cgctttctct tggtttacat tatacgcagg aagacttgtt ccaatggata 2056441 aaataaacgc catgcgatca cctctttgca tacattgtgc cgcaacaatc ttttttatat 2056501 gcaaaaaaaa ctccgccgcg gcggagttag actgctgttt tttgttcagc gaggtcagct 2056561 tcttgttcta tttttttagc tttagaaaaa acgttatata caatatttaa gacgactgca 2056621 gtaaagctgc ccgccacaat gccattcgtt gtaagcagcg ttaaggcact cggaagctgt 2056681 ttgaaaatat ccggcacaac ggtcacaccg agccccaatc ccactgagca agcaacaatc 2056741 agcagatttt cctgtttcgc aaaatcaatg cggctgagca ttttaattcc gtaagcaatc 2056801 accattccaa acatcgccac cattgcaccg cccaaaacag cggatggaat aatagtcgtg 2056861 aaagcagcga tctttggaaa cagcccaaat gccattagga tcacacctgt gaccacaatg 2056921 acggcatttt ttttgatccc tgtgagctga acaagcccga cattttgaga gaatgccgtg 2056981 taaggaaaag cgttaaaaat accgcccaga agcacagcca gtccttcagc tcgatagcct 2057041 ttagacaaat ctatctctgt caaacggcgg tttgtcaggt cacctaaagc aaagtaaaca 2057101 ccagttgact ccacaaggct gacaattgca acgatggaca tcgtaatgat aggcgctgcg 2057161 tgaaaagacg gcgctccgaa gtaaaatggc tgaatcattt gaacaactgc cgcgtccgaa 2057221 acattatcaa attgaacttt tcccataaaa tatgcgatga aggtgccaat caaaataccg 2057281 atcaaaatcg agacggactt gataaagcct tttgtaaaac ggtatagaag cacaatgata 2057341 ctcaacacgg taaaagcaag tgcaagattg gagagatctc cgaaatctgc acttccttct 2057401 ccgccggcca tgttattcat ggcaaccggc atcagtgtaa taccgataat cgtaacaaca 2057461 gagcctgtca cgaccggcgg aaaaaacgat acgagctttc caaagaaaaa tgaaataaga 2057521 atgacaagaa tgcctgaagc gataatgctg ccgtaaactg ttgaaacccc atattcagat 2057581 ccaatcgcta tcatcggcga tacagctgta aaggtacagc caagcactac cggaagcccg 2057641 atcccaaaaa atcggttgct ccacacttgc agaagtgtag ccacaccgca cataaaaata 2057701 tcaatcgata ctaagtaagt cagctgctcg acagtcagtc ccattgcttt tccgacaatc 2057761 agaggaacga caatggcgcc ggcatacatg gcaagaacat gctgaatccc taaagacagc 2057821 gttttgccga atccatttct catgaatgaa cctcctgtac gaaggacact tttccttctt 2057881 ctaaagactg aattcttgcc aaagattcca ctcggtagcc cagttttaca agttcatctc 2057941 ttcccggctg aaatgacttt tcaataacaa tgccgattcc cgcaatagaa gctcccgctt 2058001 gcttcacaat cgacacaagc ccgtgcgctg cctgtccatt tgccaaaaaa tcatcgataa 2058061 tcagcacatg atcctgatcc gacaggtggg tcccagacac tgcgatttgg ctttctgttt 2058121 gcttcgtaaa ggaataaaca gacgctgtca gcaagttgtc ggtgagtgtt aacgatttat 2058181 gctttctcgc gaagacaact ggcacaccca gcttcaagcc cgtcattaca gcgggagcga 2058241 tacctgatga ttcgattgtc acaattttgg taataccgtc ttttgcaaac ctagacgcaa 2058301 attcatcacc aattctctgc ataagcagcg gatcaatttg gtgattcaaa aaagaatcca 2058361 ctttcaatac ctgatcagat aatacgacgc cttcttcctc tattttccgt ttcagtgctt 2058421 ccatcctgtc tacctccgtt atgagaataa aaaaagcatt gcccgctcaa ataaagagca 2058481 agcaatgctg atatcacaaa aaaccgtaca cgtgcggttc cattgctcac ccatagtcgg 2058541 acatttacgg tgcccggtag aaacttgcgt gccatatcca cgcgattata tgagtgttcc 2058601 tattatattg taataaatta tatcaagatt ctaatctctt gcataggctg aaaataaaaa 2058661 ttcccgaact ttaattttgt ttttttagat atcattcgta tttcaagggg attcgatata 2058721 aaagagtctg acgaccgcgc cgccaggctt ttgattataa cagatagaga tttgaatatt 2058781 tgtttgataa ataatcaatt aaatagcgaa cattcagctc ttctcctgtt gcatctttaa 2058841 taatgtctaa cggctttttc cgttttccgt gaatgtgcac cttttccgtc agccattgct 2058901 ttatcggatg gaactctcct ctttccaaga gagcgtcaaa ttcagggaga tcctcaagca 2058961 ttttttgttt cagctgagcc gcatacatgt agccgagcgc ataggatggg aagtagccga 2059021 aatctccacc tgcccaatgg acgtcctgta aaatcccctc tgcgtcggtc tgcggtgtaa 2059081 tccctaaata atcctggtat ttttgattcc aaagcgacgg cagatcttcc acagacactt 2059141 cattgctgaa aatcgctttt tcaatttcat aacggatgat gatatgaaga ggatacgtca 2059201 attcatccgc ttcgaccctg ataaatgaag gttttgattc attgattgcc cggacaaaat 2059261 catccaggga gatgtccttg aactgtacag gtgatgcctc ttgaatcttc ttatagtacg 2059321 gagtccaaaa atgcttgttg cggccgataa aattctcgta aaataatgat tgcgattcat 2059381 gaattcccat cgatgcgccg tctgacaagt tcgtgccact gagtgcttca tcaatatttt 2059441 gctcgtaaat cgcgtgcccg cactcatgaa tggtcccaaa gatcgccgtc cggaaatctt 2059501 tttcatcata tctcgtcgtg acccgaacgt ctccccgatt cagcgtagtt gcaaacggat 2059561 gaacggtttc atcaagtctt ccgccatcaa aatcgtagcc aagctcctgt aaaaaataca 2059621 gactgagctc tttttgcttt tctttcggga acgcttttgt aataaagctt gtatctggtt 2059681 tatttccgga agctgtcacc tgtttaacaa gagggataat cgcttccttc agctcagcaa 2059741 acaactgatc aagcaccttt accgtgacgc cgggctcaaa caaatcaagc aatgcatcat 2059801 aaggatgctc ttgatatccc caatacgtaa taaaacgttt attgaattca atcagctgtt 2059861 ctaaataagg agaaaacaag ctgaaatcag attttccttt cgcttcctcc cacgctgttt 2059921 ctgcctttga acacagaatc acgtattctt tgtattcagc ctcagggatt ttcttattct 2059981 cttcatactc ttttttcgcc agttccactg cttttttcgt atcttccgac aagtcatcaa 2060041 atcgttcata caggacatcg ataagctcct tcattcgatc tgatgtttgg atattgaata 2060101 tatctgttga aagctggccg atactttcgg cacgatcctc tgagccattt ttcggcgcgc 2060161 ctgttctgga gtcccagtgc attaacgcaa ctgcttcgct gtaatgtgag attcttttta 2060221 aaagatcaaa aaattctttt tcatatgtat gtatctccat atccattccc tccctattct 2060281 agccgttcca ttacaggcta atggaagggg gtatgaaagt caaattgttt gtataaaagg 2060341 ctgccggtat gttttgtggc agccttttta ttcagttgat cgtcatttga ttttttggcg 2060401 gaggtgttct ccgctttttc tgcttgattt ttttatctac ccacactgtt gccagcgggg 2060461 ttaagagcga ggtgacaata acgcttgtcg cgataattgc agttgccgac tcagcaactg 2060521 gcgcaaatga ggcattcgct tccgctaatg catatggcac ggctacagcc gcccctgccg 2060581 tagaagaagc ggccactccc gcgacaccat ctccccgcgc aataaaacga tcaagcaaaa 2060641 acaaagaact gcccgataaa atgacgacag aaactccgat aaaaatgccg agcagccctg 2060701 attggatcag cattccaaaa ttcaaggtat tgccgagcga aaaggcgaaa aatggaatga 2060761 tcgccggcac aaccttgctg aataagtctc tgagatcatg atccagattt ccaagtatac 2060821 atccaagtaa aaacgggatg actgtcgctg ccagcgtttc ccatgggaat gcggcaagtc 2060881 ccgtcacacc aaacgtcacc atggtcataa aaggaccaga ttctgtactg ataaaggcga 2060941 aagcgcccgc atcctctttt cttcccatgt gattcatgag cgccaaatac agtccgccgt 2061001 tcgtttcatt cattaccgcg acaattgcta aaacagaaag gcctgcaaaa aagccggatt 2061061 gtatgccatc gtcaggtata aattgcgctg cgatcacgcc gagcagcgcc gcaaatccga 2061121 tcttccccaa taataacgtg attccttttc ttgcgatata gcctgaagaa cgaaaatcaa 2061181 tcgttgctcc tacgcaaaag ataaaaacac ccagtatcgg cagcgttccg gtaatcaaag 2061241 cacccgtaaa ccctccaaag aactccgctg ttccaggcgc aaacgtgttg agcgccgctc 2061301 caagaaatag cggaataatc atcattccgc caggtacccg ttcaattgtc gccttgattt 2061361 tcatattgtg gattctccca tcctccggtt atgaaaaaac aattccactt acacttggaa 2061421 aacagcctgc aaatcctctt ttgaacagct gcccaactgg ctgccgactc cgacggcgcc 2061481 agctccggct ctaagccaat caggcacttc agacggatgt atcccgcctg tcggaataaa 2061541 ggtcacctgc gggaaaggac ccgctaaatt tttcataaac ggaatgccaa acacaccgct 2061601 tgggaacagc tttaatgtcg taaaaccgaa tgtcagcgct tccataattt cgctcggagt 2061661 caagacgccg gggatataat gtgtctttac aaaagataga tgttcagcaa gatcagctga 2061721 aaaacccgga ctgacaataa actgcgcgcc agccttagca gcttccccag cttgctgcgc 2061781 gctgatgacc gtacccgcgc caattaaaat atcttcccta ttacggaagg attcgataat 2061841 atctgatgcc ccgggggtcg tatacgtcac ttcaactgca cgaatccctt tatctaataa 2061901 actctcaatc tgctgacagg cctcctgctt atcctttgaa cgaatgactg caatcagctt 2061961 tgcttctttc agacggtttt caacgacttt ggactccata ttaataatcc cctttctttt 2062021 ggtgaaccgt tctttgagca gataaaaaag aagctaattt ctccctggtc ggcaaaccgt 2062081 ccatatcccc cggtgcctgc acttgcaaag cgccaatcgc atttcccctt tgcaccgcat 2062141 ccttgtacga caaaccgtct aggataccgc tgattacacc gactgcaaat ccgtctccgg 2062201 cgccgaccgt atcaaccacc cggtcgaccc ggcagccttc tagaaatcct tcacttgtcc 2062261 ccgttttaaa gtaagcgcct tcttttccaa gtttaatagc aacaaagctg gcaccttttt 2062321 tcaaataata gtcggcaatg ccttcaggtg ttttttctcc ggtcaatagc tctccctctg 2062381 cgatacccgg gaaaaaccag tctgcaagcc cagccagatc attgattgtg tgtaccattg 2062441 ttgcttgatc aggccaaagc gaaggtctta cattagggtc gaatgaaatg gtcttccctg 2062501 cgtttctcat gtcgttcatg acatgatacg tgaagtcttt catctcggct gataaagcag 2062561 gcggaatacc tgtcacatgc aaatggcctg cgcattgaaa ataatctctc ggatattcag 2062621 ctgtagttaa tgtgcttgca gctgagtttt tcctatagta ggtaacttgc gggtcgcctt 2062681 ctttcacttt tgacttcagc agcagcccgg tgggattttc gtcctgcgag cggatcacgc 2062741 gggacacatc cactccctct tttttaagct cttgtaaaat aaacgttccg agctgatcat 2062801 tgccgacctt gctcatccat cccattcgaa atccgagtct ggcaaggccg caggcgacat 2062861 tgctttctgc tccggcaagc cctttagaaa aagtggatac ttcatgaagg cctccatact 2062921 catttgcata aaacatggcc attgattccc cgaatgtcac cgcatcaagc ttcatctctt 2062981 cccaacctcc tcttagttga gggcacctag gattaaagtg actttctcat gatgactttt 2063041 gcctctaatt caatggtttg aggcgctcct ttgtcacctt caatcctttt taatacacgt 2063101 tccatcgccg tcctgcccat atcatgtgac ggctgggcga tcgttgtaat gcctggaccg 2063161 atcagtttgt accactccgt atcatcgaat cctgcaatcc ctatatcttg agggatgcgc 2063221 aggccaagct cttccataca gctgatgatt ttcagcataa tcaagccatt caaagccaga 2063281 atcgcttttt tttgctccgg catttccttg tgaaaagaac gaagctccgc cttaagctgc 2063341 tccttgtcct ttacgtcaat ttcatgcaat ctgacaagcc cgttcacatt ttgaaccgaa 2063401 gccatttcct gatacacagc tgctctttct gcacgagggc tgatagagga aatcggttcg 2063461 gtaaacagcg cgacatcagt ataccctttg ctgtacacct tctgaagaat ctcttttgtg 2063521 atccatctgt tgtcagtcgt tacggtatcc agtttcagat ccggcagttt ccggtcaatt 2063581 aagattgttg gaatttgctg ttcagcaaaa gcgcggagta catccttgtt ttcccctgtt 2063641 gcgtttaaaa tcaagccctc aaccgaatgg gcttctagct ttaagagcat ttcccgctct 2063701 ttttcaggac tgttatctgt gttgcacacc ataatgctgt atccatattg atcacaaacc 2063761 tcttcgactc ccctgaaagc agcgaccgaa aaaggatttg taatgtcagc cacaacaaat 2063821 ccgattaact tgcttttttt tattttcaaa ccttgtgcca ttttactcgg ccgataattc 2063881 aattctgcga ttgccttttt aatgtttttc actttttcag gagaaatcgc gtcaattttt 2063941 ccgttaatat agcgggaaac tgtcgatttc gaaactcctg cacattcagc tacgtctttg 2064001 atggttgtat ggcctgttgt tttctttttc attcaagtgc tcctgtatct catatatttg 2064061 aaaccgattt caaaaccgtt acaacaaaag aataccataa ttttaaaatt tgggaagagt 2064121 ttttttaata atatgtcaat tcattatttt ttcgttgact cttttcacta tttatcctaa 2064181 aattttcttt gaaaccgtta ccaaaatatt ttcattcaag tgatgctgaa atcctaacca 2064241 agggggaaat ataatggaaa atcgttattc tgtacatcct gaacaagtaa aacgctttac 2064301 aacagaggag cttcgcagtc atttcttaat ggattcttta tttacagaaa acaaacttac 2064361 gatgtattac tcacatgaag accgggttgt catcggcgga gcggctccag ggcaaagtga 2064421 actgaagctt gatgcaggtg attttctaaa aacagacttc tttttggaac ggcgtgaaat 2064481 cgggattatt aatgtcggcc agcctggtgc cgttagagtc ggcgatgatg aatatgtgct 2064541 tcaaacaaag gattttctct atattggaat gggcaatcag gatgtatcgt tttcaagcct 2064601 gaacggggaa aaagcgaagt tttacttcgt ctccgcttgc gcccacaaaa gctatccgac 2064661 acaaaaagcc gccctatctg aactgacacc ggaccgcctt ggtgatgatg cagcgtctaa 2064721 tgtcagaagt ctgtacaaag tcattcatca ggatggcatt aaaagctgtc agctgatgat 2064781 gggaataacg atgttagatc aaaacaacaa ctggaatacc atgccagcac acgttcatga 2064841 ccgtcggatg gaggcttatc tttatctgga tcttgaaaag gactcaaagg tatttcattt 2064901 catgggccag ccggacgaaa cacgccatct tgttgttgga aatgagcagg ctgtcctttc 2064961 tcccgcttgg tctattcatt ctggcgcagg aacatcaaac tatagctttg tgtgggcgat 2065021 ggctggagaa aattacacat ttacggacat ggatctcatt ccaatggatg ggctgaaata 2065081 agatgggtta tctacatgac gccttttcat taaaaggaaa aacagcgctg gtgacaggcc 2065141 cgggaacagg gatcggtcaa ggaatagcca aagccctagc cggggctggc gctgatatta 2065201 tcggcacatc acatacaagc agtctgtctg aaacacagca gcttgtggaa caggaaggcc 2065261 ggatatttac atcttttaca ttggacatga gcaagccgga agcgataaag gattctgcag 2065321 ctgagctgtt tgaaaacagg cagatcgaca tccttgtcaa taatgccggc attattcatc 2065381 gggaaaaagc ggaagatttt ccagaagaga actggcagca cgtactgaat gtcaatctaa 2065441 acagcctgtt tattctgaca cagcttgctg gcaggcacat gctgaaaaga ggtcatggaa 2065501 agattattaa tattgcctct ctcctgtctt ttcaaggcgg catcctcgtt ccggcttaca 2065561 ccgcgagcaa acacgctgtt gccggtttga caaaatcatt tgcaaatgag tgggcagcgt 2065621 caggtattca ggtcaacgca atcgccccag gctatatttc tactgcgaat acaaagccta 2065681 ttcgggatga cgaaaagcga aatgaggaca ttttaaagag aattcctgcc ggccgctggg 2065741 gccaagcgga tgatatcggg gggactgcag tctttttggc atcacgtgct tcagattatg 2065801 taaatggaca tattttagca gttgatggcg gctggctatc ccgctgacaa ataaaaaagc 2065861 tgacgaacga tcgtcagctt ttttccatta catcatgtgc ggttcaacag gcaagacctt 2065921 tttgacctca tcaatgatgc gttcattttc tccgccagcg taaatgtgaa tcgagccgct 2065981 gtcttgattc gagcgaatca ggcgcccgat gccctgccgt acacgtaaca acatatatgg 2066041 cagatcaact tcttcgaacg gatctttttt cgctccgttg cgcttcgctg taaatacagg 2066101 atcgtgtggc gggaacggta atgaccaaat ggtaacattc ttcaatgcgt caccgggaat 2066161 gtcgagtcct tcccataagt gaactgaaca aagtactgtt tcttcttcct cttggaattt 2066221 ctctactaag ctgctgattt cctcatcacc ttcgaagaaa attggatacg gcagctccca 2066281 tgccgccgac agctctttaa actcgtttaa ttcttcaaaa gaagggaaaa gcaccagcgt 2066341 tcttcctttg tatcgtttga ttgtttcaat cgtttcagcc gttttttgtt cagcgtccat 2066401 atctgttttt gcgtatagat taatactcat ttgctcgtca taatcataag gggaatcaac 2066461 agttaatgac aaataatcat gaatcccaag actgtcggca atataatcaa acgaaccgcc 2066521 ttctgacagc gtagcagaag aaaagatata aggaattttc ttagaaaaca ctttttcgcc 2066581 aagtacttct gctaccgttc tcggcatcac gacaaaggtt gattctgctt cctttttctc 2066641 cagccagctg atcgcatcct tttgatatag agataatgaa tacgccattt gttcaacata 2066701 ttcttccact actgacagtt cgtattgatc aatcgtatac atttcagact caaatacaag 2066761 tgcctcaccg attttatcaa gtaaacggca aagctcgtcc gccgcctttt tgacacgatg 2066821 gtcatttttt atttctaaac ggtgtgaacc ggctacttcc tttgattctt cagaaagaac 2066881 atagaaaaat tcgtcgtttg cgagaagcgc atcttcaatc aattctgcaa actcttctct 2066941 gatgtcattt tgcagcaatc gttctaaaaa caattcaaga gtagactgct tcactctata 2067001 ggttagcgct ttttgcgcag caaactctaa caagtgcccc tcatcaaata caactgcact 2067061 atgatcaggc aagagcggca gctggccctc tcgtttgcgt gattcttccg tccacacatg 2067121 ctccatataa aaatcatggg aacaaatgat taagtccgtt gacttgcggt agtaatctct 2067181 ggaaagtgtc agaccgcatc tgtgtctcat atcacaagtc agacagtcct gaaacgagtc 2067241 gtagcttacg tcagaccact cttcattcga tagatttgcg tactgcttac ggtcgccata 2067301 cggataaaag cgctgcatcg cctgggactc gtggacaaat gacggtaacg actcataaag 2067361 atccagccat ttatcatcat cagaacgctg cattgttttt tcaagcttct tcaagcataa 2067421 atattgctca tgtgattttg acagccttgt atcaattttc agatcaagat gctcagccag 2067481 cttagaaata tcgccctctt ttttcaccag ctgttcaatt aatgtttcat ccgcacaagc 2067541 gatgatggca ggtttgccga cataccttgc atagctgatt gcaaaaagaa gatataccag 2067601 cgttttcccc gttcccactc cagcttcggc gaacatgact tttttctctt taaacgcccg 2067661 ctccagctga aaagccataa atacttgctc gtcccgaaga tcaaaccctt tttcgggaag 2067721 gatatcgtaa aacacgtcac caatccaatt gttcaattct tcataaaaat tctttgtttt 2067781 cgttaaagaa aaaggcaaac gtgatgttgt cacctagttc caacccccaa ctattcgaca 2067841 ttcagaccac caataatatc attttccgct gatgaataca ataaaaaact tggcaatgcc 2067901 aagttttttg cagtttactt acgattgatc acatgcgacg ataaaaaagg atggtctgtt 2067961 gaataaatat gttctaccgc tttttctaaa tcagtttgcg catgcgaaat cacagacgga 2068021 gacgaatcag tcccgagctc cttcagctcg tttgctgttg cgtcaagcgc cctttgaata 2068081 agattaaaat gttcgctgtt cagcatgaga tcacctctga tggaaataat catcattgta 2068141 tgcgaacttt tcattttata tacatgcttt accgcatgtt atcaccgaaa catgcacaaa 2068201 ctacacttga tattccgtct ccggattatc cgtcttatca acaatattct atcagggagt 2068261 gatgttgaca tgagttatag aaaccgatta gatcagcatt ctgaactgtt tcatcacaat 2068321 tggacgcggc ctaaacgttc aaagtctcaa gtaaacggtc acactgaaat gtcccaaacc 2068381 aacattatat tgagaagcaa cgcgaaagct caccgttggt aacgatagaa tagggctgaa 2068441 agatgaaaga agacgcatgc agagcgtctt ctttttatgc gttttctgtt ttcttgcgct 2068501 gcggtcttac ttttgaccag tattgataat aatccgtttt aataaacccg ttaaagagtt 2068561 ttcgtttctt cgttgctttt ctgccatatg cttcctcaaa gttttcattt gatgtcagca 2068621 tatacacaga ccaagtatca agcggctcga acgcctgccc catttctttg tacatctgct 2068681 caacggcttt tttctcgccg agacgctctc catatggcgg gttgccgaca attacgccaa 2068741 attccagatt tgtggtaaag tctttgacct gcatctgttt gaactggatt agatctccca 2068801 atcctgcttc ctctgcattt tcttttgcga tttgaaccat gcggtggtct atgtcgctag 2068861 cgaaaattgt aagcggctga tcataatttg ccttttcttc gacttcaagc cgcgctttgt 2068921 tccacagatc tttaccgatc cattcccaat cctctgatac aaaatcgcgg ttgaatcccg 2068981 gggcgatgtt ttggccgatt agcgccgctt ctatcgcgat tgttccggag ccgcagaaag 2069041 gatcaacaaa cgggcggtca ggcgtccaat tggttaattg caccaaagcg gcagcaagtg 2069101 tttctttaat cggcgcaccg ccctgatcga cacggtatcc tcgtttgtga aggcccgtcc 2069161 ctgatgagtc cagtgtaatc aaagcctgat ctttcaataa agatatttcc actttatact 2069221 cagcacctgt ttcttcaatc caatcattgg ctttgccgga ctgcagcttg agcttttcga 2069281 caattgcttt tttgacgatc cgctgacagt caggaacgct tgcaagtgtt gattttaccg 2069341 attttccgat gacagggaat ttcccgtttt caggtataaa tgagcgccag ttaatcgctt 2069401 tcgttttttc aaacagttca tcaaatgttt tcgctttaaa agaagcaacc tgaaccttta 2069461 tgcggtcggc tgttctaagc caaaggttcg cacggcagat ggcaagtgca tcaccttcaa 2069521 aaataacttt cccgttatca accttgcatt cgtatcctaa atctcgtact tcctttgcga 2069581 caacagcttc aatgcccatc ggcgccgttg caattagtgt atacttcttc atcgtatcac 2069641 cctgtctttt aaaacttttc tcttttcaag ataaaagctc tccttatacg ggagagcttg 2069701 ttttcatcat tttaaatgta agtggtctaa cgttctgtaa gccatgtttt gttccatcgt 2069761 actgcaaacg gctcatcacc tcgtactcag gcggcaatca tctatctaca gaaagcattc 2069821 tgtccttctc tccgttgaat tccgttaaga aggttcccct accaaaattt gggtttctcg 2069881 ctcgaggggt ttaccgcgtt ccactctcac catttctagt gagacttcgt cactgtggca 2069941 ctttcaagga tactcagcca tatccgaaga cgtaggcttt tttcctgccg tcagcctcta 2070001 aagactgccc tagcttatga cttcgctagg cacgaacact acgggcatct cagcaccgtg 2070061 cgagcatgga ctttcctcta cagattcaag atctgcagcg attacccgaa cgttaagaac 2070121 atgaattatt atataacaac tgattacaat ttacaagcgc catttttttc aagcgtgatc 2070181 aatcataaag cttgctgcca aaaacgtgtt tttctaagtt agacagccgt tttaaaatat 2070241 caaagtttgt tgtgttagat tgcacaggct gttttttgct ggcttcttca agctgttttt 2070301 tcagctgcag attttcctgc tgcagttctt caatttcttg atggaaggtt tcataatcct 2070361 taataatcat atctaaaaat ttgtcaacgt cttcttgctt gtagcctcta acgcctgttt 2070421 taaattcttt ttccaaaatt tctttcgcag aaagctttac tttatcagca agcatctttt 2070481 tcacctcgta tcgtgaatca tcacatatat tttttcagaa atctgtacgg ttgtcaaatt 2070541 tctctctcat tgttagtagc tgtcttcctc cactgtcact ctcaagtcat ccattgtaat 2070601 aaagtagatg ggatagccat cctgttcgcg ccttttttcc gctgtcccaa gcatatactt 2070661 aggggagcct tccttttccg ggtcatataa aagcagaagc ccgtcggact tatcaatgaa 2070721 gaactgattt ttttgtttga attgaagcgg gctttcataa ggacggtgag tcaggcttgc 2070781 ttcatagtct gcctgagcca gaactgcttc atactgttct ttattcggtt ctttccagtt 2070841 cttttcctgc tcgtaaaatg gtgtgatgac agctaccttt aagtcagggt attcctcctg 2070901 caaatcatat gcagcttctg ccgcccacag ctcaactcca agctggcccg aaattaaaat 2070961 ccattctaat ccttcatcca aaaaagcaat cagccggttt ttaatggctt tttttatgta 2071021 atacagcgcc ttgtcatcct gcttaaatat ccccagttca aacggtttat agcccgttat 2071081 tgccaatact ttcatcattt cacctgcttt aaaaaatggg gctcccgtgg gccccatttg 2071141 ttgtgctgca ttgtttacac catcaagctg cacgttttcc atactagtag tcgcagcaag 2071201 gttttcctgc ttgaaaatgc tgatgcgtag ccgggtcaac atttgagaaa gtgtgtggaa 2071261 agtagtgaac gtgctgaaaa tgctggtggt ttacgtttgt tgtatgctgt gggtgaatgt 2071321 gcggcacgat agtcttcgaa aacgtatggt gttcacagca atgagtagga tggacaattg 2071381 gcgccatcat atgcggtctg cagtgatgca tgataaaatc ccctttccat aaactttatt 2071441 acaatactaa gttatgaaaa ataaggggta catgttctga tgcaaagacc tattttaaaa 2071501 gtgtgcaatt aagctgtctt taaagtttga aaacacaaaa gcaatcaaaa ataccacaac 2071561 aaagaacaag taaaaaacac ccttatacat accaactctc cctttaaaaa taactaacgt 2071621 cattttacag gattcgccgc tattctacaa caaaatcaat gtgaattcag caaaaaaaat 2071681 tcatggcgaa acaagtcgtc ttttgcgctt tcccggggaa tatttaagag gaatatttcc 2071741 tctttagccg ggcaattctc acatgcagtt tttcagtttc tttctctgat aagcatgccg 2071801 catcgctaag cgattgctct gctacttgca atgcttttcc gaattctttt ttcttatgct 2071861 caaaatattt cgcgagctct attacagcag cgtatctgca cttctggttt tgcgagcggg 2071921 acagcttttc ccaaagcggc actgcttctt ccaagcggtt ttgttttttg tacaggagcg 2071981 ataaatccag ccgtgcactg tcctggtcct caaacgattt ttctataagc ctttccaact 2072041 gcttgatcgc ttggtccgtt tctttatgag ccataaacca tttcgccata gcataggctt 2072101 cactgtgttc ttttggcgca tgtgattctg aaaggatttt tttagacata tggatgtaca 2072161 atgaaatgag tgataacaca tccatttcat tatgatgcag gacacctttt aaaagatccg 2072221 gctcttgcgc cttgataaaa tgaaagtaaa gcattggcgc caagtagccc ggtgtgtctt 2072281 ctagcctgcg gatgccgagc tcctcttttt caaccgtgcc aagagataca cggtccattt 2072341 tgtgtttcca caggcgtcta gctccatgca aaagatcaaa gtggccaaac tccggaagct 2072401 tcggaagtct gtcacggatc aaggtgtgcc ttgttttcac ctgcggccaa tcaaaggctt 2072461 tgccgttgta ggtcacaagt gatgtaatgt caacctcgct taaaaagctt tggtacaagg 2072521 cgacttcgtt ccccggtttg ggcaaaagat gctgtttgac tgtcactcgg tcttcatata 2072581 ctctcgcatg cccaagcaaa aaaatggtat tcccagctcc acccccaaga ccggttgttt 2072641 ctgtatcaaa gaaaaagagg ttgtttttgt tatacccttt tgctgacaat gtatgcgaca 2072701 ggccgctttg attccacagt gtgatcactt cctcaagctc agaaaagctg tataacccat 2072761 ggcggtgaga aagcggatat tctacttctc tgatgaggca atattcatct tcgaagatga 2072821 aaggcttcat gccaaaagcc tcccactctt ctaaaaacgg gatgtcatca aagtggtttt 2072881 cttgtttgcc tgcttctatt ttttgttctc cttcgtcgag cgccatgtgc tttttcatcc 2072941 gttggagttt cccttttaat gacatatccg gcctccctcc ttacgacatt tgatccaaca 2073001 gctgcaaaat tctttccttt gcttttatcc cttctatttc cgtacctata caagacggac 2073061 agccgtcatg acaaggacaa tgtgtaatca gttgtttcgc cgcttcatta atgtctgaaa 2073121 aacgtttaaa gacttcctcc gccaaaccga taccgcccgg ataatgatca tataaaaata 2073181 tggttggcaa tccggtatgg gctgctttaa tttgagaaac aacatgaaca tcatttcgat 2073241 cacacatgat atacacaggg acaatatgct gcagcacatt cgagatgcca agaagcagct 2073301 gttccagtgt cttttccccg atgtcttcat ccgctgtttt gatttcgagc caagctgcac 2073361 ttgtatgcag ttcttcttcc ggcaaatgaa taggtccaga cccaatattt tcaaaagtgg 2073421 tcatttttat ttttttaaaa atggtcggca gggcattgac agtgacgtct ccgtagtgca 2073481 atgacgtacg gcttttttct ttcgttttat cgatttctaa taccttcagc tgaactgcca 2073541 ggtttgcatc cgtataatat tcgacatcga cttttctgac atacgccttt ttatggtccc 2073601 aatcgagctt ctcaacttga tactgaacgc cttcatgcaa ataaatcgct tcatcatgca 2073661 aaagcgtcat cgcactaaaa cggtccattt caccgataat ccttacattt gcaatatccg 2073721 actgatcaac tataacgaca ttttcctggg aggcggaacg caaactgatg tttgacgcag 2073781 ggaacgactc acttgcccaa tggtaccgtt cgccgttgcg gtgaagaaca gcctcttcct 2073841 gaagatactc aagaatatca ctgacttcca tggctccaaa ttcttcatca gctctaaaag 2073901 gaagctcata agccgcacac tttaagtggt ctactaaaat aatcaaattc tccggattga 2073961 ttcttgcaga ttccggcgaa cgattaaaga aatattcagg atgccgcaca atatattggt 2074021 caatcggtgt tgaattggct accatgataa tcaaagattc accgtgtctt ctgccggctc 2074081 gtcccgcctg ctgccaagca cttgcaacac ttccgggata ccccgtcatt acacacactt 2074141 gcagctggcc gatatcaaca ccaagctcta aggcattcgt actgaccact cctaaaatgt 2074201 cgccttctct cagtcctctt tcgatttctc ttcgctcttt cggcagatag cctccccgat 2074261 agcctctgat tgattttgtt ccaatctctt ttttcacaag ctcctgaata tggcttaaaa 2074321 taatttccac ccgaactctg cttctggcaa aaacaatggt ctgcactttg tttttaagga 2074381 actctttcgc cagttcattc acttctgcgg ttgcgctcct tctaatattc agcggtttgt 2074441 tcacaattgg cggattgtaa aacacaaaat gcttgcgtcc gctcggtgcg ccgttgtcat 2074501 cgaccagccg catcggtttg cctgtcagct gctctcccaa ttcctttggg ttggcaatcg 2074561 ttgcggaagt acaaataaaa actggatcac ttccataaaa ccggcagatc cgcttcagcc 2074621 gccggatcac atttgccaca tggctgccga acacacctcg atacgtatga agctcatcga 2074681 tgacgatata cttaaggttt tcaaacaaac tgacccattt cgtatgatgc ggtagaatgg 2074741 cagaatgcag catatcgggg tttgtaatga caatatgacc tgcttttctc accttttgtc 2074801 tgattgccgg agacgtatcc ccgtcatatg taaagctttt aatatcaatg cccatttcat 2074861 caataatttc atttagctcg ctcttttggt cttgtgccag cgctttagtc ggaaataaat 2074921 ataacgcccg gtttgtttca tcttgggcga tggactgcag gactgggagg ttgtagcata 2074981 acgtttttcc tgatgctgtt ggcgttacgg taacgatgct ctctcctttt tgcacatatt 2075041 gaaaagcgga atattggtga gtatatagtt catcaatgcc ccttttcgaa agggccgctt 2075101 tgattctctc gtctatactt tcgggcatag gccttgtttt tgcttcccga ggctcaattt 2075161 catgccaatt cacaacgttt tcatttcctt ttaaatcaga aatgagttca gtcagtgatt 2075221 tctttttcat tctttacacc tctttgtcaa gtacagttta ccgaatattt gtttgcatgg 2075281 ctaggtgcaa attttataca gttgaataaa aaaagcaagg catacgccct gcttatttcg 2075341 cttttattgt aaagagcttt gattcgcctt tacgagcagc cttttcgcct gccgatacca 2075401 ttgatcctac agcctcacca ttcattataa cgattgggat gactgtgctg ctcgcttttt 2075461 cttttattaa ttccaaatca catgtaatca gcgggtcacc gaccttcact ttatcccctt 2075521 ctttaatgtg ggcagtaaat ccttctccgt tcatattgac tgtctccagc ccgacatgaa 2075581 ttaacagctc aattcccgag cgagtccgaa tgccaacggc gtgtttggtg tggaaaatct 2075641 gaatgacttc accttcagcg ggagaaacga tttcaccgct agaaggttcc accgctattc 2075701 cttctcccat cattttctgt gaaaaaacag ggtccggtac atctgacagg tccattactg 2075761 taccgtctgc cggagaataa ataacctctt ctgtcacctt ttcctgaatt ttgcccattc 2075821 cgaataattt tttcagcaat gtattttctc ccttctcatt cacttcaacc gttatccctt 2075881 cattcaccac tatttaacca cactttcaat tttgcttcaa tttataacaa catctggcat 2075941 agacgcataa tctggttaaa aaaggcggtg gcgatattgg aattccatga tgacaaaaag 2076001 aacgaactgc aaaagaaaga agaaatcata acggaggcaa tcgacactct ttttcaatcc 2076061 tcagcgttcg gcaaccttat aaacggattt cagaacctaa tcaactcgag tttaaaggat 2076121 gtgcagacga ccatacatgt cagagaaaga gatactgggc tgtatatcga tattaccatt 2076181 ccggcgacgt ttcgagatgg cgagatcgtc gttgatgtta aatcgaggta tctccatgta 2076241 acactccaag aaaaacagaa acaccaaaat gaggctacct ttacaagcat gacaagaacg 2076301 gttcagctgc cttatgaagt tcgccaagaa gatatggaaa cgtcttggaa cgagcagaca 2076361 atgacacttt tctttccaaa aaataagcat gaatgaacga ttcattcatg cttctatcat 2076421 ttaaaaaagc tggtaaatcc ctttattaaa gatccgacct gattcattgc actcattact 2076481 tgacctgtcg tatccatcat tttattaaaa tcaaattgcc cattggcttt tttgaactgc 2076541 gacataatgc tttgaaattg tgaaggctgc tgttgattag gccttgggat aggataaggg 2076601 ttagaaaata caggcggctg cataggcata ggctggatcg gagcataagg ctgataataa 2076661 tcctgctgtc cataatgctg ctgaggcagt tgttgctcta aataaccggg tgcagcctgc 2076721 tgataatatc cttgcatatg ctgaggataa taatagccca tttgccgagg atagcttcga 2076781 gagctcccgt tcattgcgat tcccccctaa acacaacata tttctcttct atatatgtat 2076841 gaatgacttc tattgtttgt gtcacaagtg atgattagca tttgtcaaat tgtgtcgaaa 2076901 gtttaaattt tttaaaaaca gaaaaaagtc gaatcattat ggtaccatat tttcaataca 2076961 gatgagaggg gatgcaccat aatgaacgta tcatacttaa gcaaacgttt tgcagaaatg 2077021 aagaaatatg aaacagactg tatgaataaa ctgatggact ttgccaagtt cctctatatt 2077081 caaggacatc tcagcataac tgagtttcgt aacagtatga aggttctcga agcaaatgga 2077141 gcagaaagcc cggcatatga gatgaattaa cgtccggccc cctataaaaa cgaaaagaag 2077201 acagcctttt accggctgtc ttctcttgca atttcatcct ttactgcgtg caatgtataa 2077261 aggactgact cagtgatgtc cttgaatcgt tttttatgaa tatgatgaac ataagattga 2077321 aggaccaatt ccaggaaatt atcctttacg gcctcaattt gctctttatg cacatatttt 2077381 ggccggcgga cttttatcaa ttcaagagca ccctctgccc agcgagcagc cagttcatca 2077441 ttctcttcaa ctgcaggctt tatcgtctca aaaaaatcat aagaatgatt actgtttttt 2077501 ccttcctgat accgatcagc gcctttttca gcaacttcaa tcatttgctc ggtcatttcc 2077561 agcaaagttt gtgatagcaa tatctttcac ctcaatgcct atcgtaccaa atttcactca 2077621 caaattcagc cgatgcggta taccttctca aacgcatacc tgtgttcagg cgattgatac 2077681 agctcattta tacaaatatg aagatctatg atttcttctt cgagcacact taggcgatcg 2077741 ttctccgttt cccgcatctc agcctctaat gcatttacag aatgattcag gctttgctca 2077801 gctcgcgtta attcatcttc tatatcagaa agcatacgga gaatatctgt cttgcataca 2077861 taaccggaca ttcgtgtacc tccctttcct tgtctctccc ggttaacatt ctttgctctc 2077921 aaggctcttt ccttcctcat gacaaaacta gaagcaaatc gccaaacaaa caggtattcc 2077981 acgaaaagct gaagttttcg acaaaaacac ccgcaaaaat tgtatgatcc tcctcattaa 2078041 tgcaaacgat acttgtgagg aggtgccgta tgaaaacaag accgaaaaaa gccggccagc 2078101 aaaaaaagac tgaatcaaag gcaatcgatt ctttagataa aaaattaggc ggcccgaacc 2078161 gcccttctac gtaagaagca aggaatttcc ttgcttcttt attttttcag ccactgctcc 2078221 accgcaaaaa gcgcatgaag ctggcgcttt ttatgtaaat accagtctgt caattcaatc 2078281 tgcttcggca attcctcgcg cctaaagaac gttttcttta tctttccatg aaaccaatct 2078341 gttttcgttc cgtctaatga gtggattaac tcagggtagc atgtccttag cataggagat 2078401 gttctttttg taatcccgat catcttttcc atatcaaaac gggaacctgt gtgcggcact 2078461 gtgtgcaaaa agtgataaaa agaggagaac aattctggct tgaacagcaa ttgagacagc 2078521 tgctttccca gccttatcct ttcctccgcc tttgaaaagc gtttcactga aatgccgtaa 2078581 aaaaacccat ttgaggaagg aaaaataacg gtgttaaaat gaaaccagtc acttaaataa 2078641 aaaggaatcg tgtcaaaaac attcttttta aacgaaggat tttgtataat aggtgtttgg 2078701 atagtgtttt gttcatttat aatgagggca tacattagcc gctccgtatt tcgctcatgc 2078761 caaaaacggg tccattcttc cgacataaat tgtgagacgc caaacacatg cagcagatga 2078821 aacagcggtt tcccaactct ttttgaccag tggtataaaa gaagctgcgg ataggcatcc 2078881 gaaaaaataa gccagttcgc tctttcatag gctaaaaaga accatttttg ctgtctctca 2078941 cggagtccaa gctgaaacag actgcctttt aagtcagtca ttgaccagcc ggcattacga 2079001 gaaacgaaag aagccaaaag cgaccatttg atttccggat gacggtcgta aaatgcttta 2079061 taagcatttg ttcttgaaat gttatccgcg tttttcattt ttgtctgccg ctcaatccgg 2079121 ctcagaagct ttctgatggc ctgttgttct tgcacgttca ttcacttccg tcatgattag 2079181 tttaataagg aggatgagaa agtgattcgg tatcctaatg gaaaaacatt tcagccgaaa 2079241 cattcggttt catcccaaaa cagtcagaaa agggccccgt cttacagtaa tcgcggaatg 2079301 accctcgaag atgacttaaa cgaaacgaat aagtattatc tgacaaacca aattgccgtt 2079361 atacacaaaa agccgacacc tgttcaaatt gtaaatgtcc attatccaaa aagaagtgcc 2079421 gcagtgatta aagaagctta ctttaaacaa tcatcgacaa cagactacaa tgggatttac 2079481 aaagggcggt atattgattt tgaggcgaaa gaaacgaaaa acaagacctc tttccccctg 2079541 cagaattttc atgaccatca aatcgagcat atgaagcagg taaaggctca agacggtatt 2079601 tgttttgtta ttatatccgc tttcgaccag gtttattttt tggaagccga taagctgttt 2079661 tatttctggg acagaaaaga aaaaaacggc agaaaatcaa ttcgaaaaga tgagttggaa 2079721 gaaacagctt atccgatttc tcttggatac gcacccagaa ttgattatat tagtattatt 2079781 gaacagcttt atttttcgcc atcatctggt gcgaaaggtt gattaacgaa aggttgagat 2079841 gttatgtcag atcaatttaa cagccgtgaa gctcgacgaa aagcgaacag caaatcgagt 2079901 ccttcaccga aaaaaggcaa gaaacgaaaa aagggcggat tgtttaaaaa gacccttttc 2079961 actttactca ttctgtttgt tttaggcgta gtcggcggtg ctgttacatt tgccgtcatg 2080021 gtttctgatg cgccgtccct tgatgaaagc aaattgaaga cgccttattc atcaacgatt 2080081 tatgataaaa atggaaaaga gatcgccgaa gtcggcgccg aaaaacggac ctacgtctcg 2080141 atagatgaaa ttcccgatgt tgtaaaagaa gcctttatcg cgacagaaga cgctcgtttt 2080201 tatgagcacc acgggattga ccctgtccgt atcggcggtg cattagttgc caactttaaa 2080261 gacggcttcg gggctgaagg cggaagtacg atcacccagc aggtcgtcaa aaactccctt 2080321 ctttcacatc agaagacgtt gaaacggaag gtgcaggaag tatggctttc gattcagctg 2080381 gagcgcaatt actctaaaga tgaaatttta gaaatgtatt taaaccggat ttatttttct 2080441 cctagagcat acggaatcgg aaaagcggcg gaagaatttt tcggcgttac tgatttaagc 2080501 aaattgactg tcgaacaggc tgcgacgctt gcaggaatgc cgcagagccc aacagcgtac 2080561 aacccggtca aaaacccgga taaagcggaa aaacgacgga acatcgtact cagtctgatg 2080621 aaaaagcaag gatttatttc tgattctcaa tataacaaag cgaaaaaagt ggcagtgaaa 2080681 gacgaaggcg tcgtgtcaca gaaggaatat gaaaaagcaa gtacaaacaa atacagcgca 2080741 tttgttgaag aggttatgaa ggaaattgat gaaaaatctg atgtcgatcc atctgctgac 2080801 ggattaaaga tctatacgac attagataca aaagcacaag ataaactaga tgaattaatg 2080861 gacggagaca ccgtcggatt tactgaaggc atgcagggcg gtgtgacgct tctcgatacc 2080921 aaaaacggag aagtccgagc gattggtgcg ggacgcaatc agcctgtcgg aggctttaac 2080981 tatgctactc aaactaaggc acagcctggt tcgaccataa aaccgatttt ggactacgga 2081041 ccagttattg aaaataagaa atggtccaca tacgaacaaa ttgatgactc agcttatacg 2081101 tattctaacg gaaaaccgat tcgtgattgg gaccgcaaat atctagggcc tatctcaatg 2081161 cgttacgctc tggcccaatc aagaaatata cctgctttaa aagcattcca ggcagtcggt 2081221 aaagatactg ctgtagactt tgcaaatgga ctcgggcttg gtttaacaaa agataatgta 2081281 acagaggcct attctattgg cggtttcggt gggaacgatg gtgtttctcc tctgacaatg 2081341 gcaggtgcat acagcgcgtt tggaaataac ggaacgtata atgaaccgca ttttgtaaaa 2081401 tctatcgaat ttaacgatgg cacgaagctt gacttaacac caaaatcaaa atcagccatg 2081461 agtgattata ctgcgtttat gattacagat atgctgaaaa cagctgtgaa gacaggtact 2081521 ggacagcttg cacaagtacc tggtgtagaa gttgcaggaa aaacaggaac gactaacttt 2081581 gatgataatg aagtcaaaag gtacaatatc gctagcggtg gcgcccgaga ttcttggttc 2081641 gttggctaca caccgcaata tacagctgcc gtctggacgg gaatgggaga aaacgaggct 2081701 ggaaagaaat cactttcagc tgaagagcaa aaagttgcaa agcgcatctt cgcccagctc 2081761 atcgccgatg tcgatgacgg aagcggatca tttgagaagc ctgacagcgt agtggaagcc 2081821 accgtagaaa aaggttctaa tccggcaaaa ctggcagggc caaatacgcc aagcgataag 2081881 aagctcacag agtactttgt taaaggcaca gctccttcta ctgtttctaa aacatatgag 2081941 aaagaagaaa aagaggaaac agctaaactg tctggtttaa acgtgaaata cgataaagac 2082001 aatcaatctt taacgttaag ctggaattac gacggagatg cgacctttgc tgttaagcaa 2082061 tctgttgacg gcggcagcta ctcggaaatt caaaacagct ctgcaaaaga ggcagttatt 2082121 tcgggtgtgc agccaggatc tgtatacaaa ttcgaagtaa cagccgtcag tgatgatggc 2082181 aaaagtacag cttccacatc ttatgaggtg ccaaaagctg aagacgatga agataaaaaa 2082241 gaccagcaac aaacggatga tgaaaaacaa gatgatgaga agactcagga tgatacacaa 2082301 actgatgatt ctcaaaaaga tgacggtcag acggatcaag atcagacaga tgattcaaca 2082361 aacgatcaag acaaaaaaca agacaatacg aacaccaatc cgtccgacaa caataaccaa 2082421 gaccaatcaa acgataatga taacgacaac agtaacaacc aggatacgtc ggatggtgat 2082481 tcgaactctg gtaagaatga ttcaacaggt tctgacacga ataaaaataa aacagacaca 2082541 tctaataaaa cacaaacaaa ctcatcatcc attgaaaaaa caaattaaac aaaaaagccg 2082601 tcacctttgg ggtgatggct tttttggtac acaataaaaa acctcccgtt ttaacaggag 2082661 gttttatcga ttcatcgcat gatatttata aaaatgcttt ttcatttcgg taatcagctc 2082721 atcaagctga ataaagcaat ggtattgggt cggcttaaga agaataaatt ccactcgttc 2082781 agcccaatta atcggctttg cgggatatga tttctccctc agttcttgcc aatcgagcga 2082841 tttcaccggc tcacctgctg tccaatgtaa cgaagccagc aaacacacaa tgccctttaa 2082901 catttcgttt tggtcacatc tcgattttcg tgtttgaaag actgggagaa gtgatgcttt 2082961 gatgtcatcc cacacttcaa ataaaagcgg aacgtatttc ccgctgtcct cccatggcaa 2083021 atcgccttgt aattccgtgc agaaatcaaa atacacggga ttggtctgca aggttttctt 2083081 catatccgag gaactcttct ggccaagact gcgcaagtat tgctcatagg aagccaacac 2083141 ttcttttgct tgcgtcatcg tttcaccagt ccttttttat ccctcttctg cccttctctg 2083201 cacaaagaaa gcagcggaca ctccgcacag cgcggagatt gggctttaca gtgatatctg 2083261 ccgaagaaaa taagccggtg atgcgtaacg gaccaatctt ctttgggaac cttgcgcatc 2083321 agcgtctttt caacttccag aaccgagtcc ttccaccggc aaatgcccaa tcgtttgctg 2083381 actctctcca catgggtatc tacggctatg gccggcacgc caaacgcaac ggataccact 2083441 acgtttgcgg tctttctccc gacccctggc agtttgacaa gctcatcgcg gtctctcggc 2083501 acttctccgc cgtaatcttc aataatcatt ttactcagct tttgaatatt tttcgcttta 2083561 ttacgatata aaccgattga tttaatatcc tgctgaagct cttccagcgg aacagccaaa 2083621 tagtcttccg gccgtttata tttttggaat aatgttttgg tcactctgtt tacaagtgca 2083681 tctgtacatt gcgcagataa agcaacagcc accactaatt caaaaggatt ggaatgaacc 2083741 agttcacact ccgcatgagg aaacatgtca cctatcttgt ctaaacagaa ttcaatttgt 2083801 tttagattta acacgattgt caccttttca ctttattgtt caagccaatt gtaaaaagga 2083861 acctgccttt tatactcttt ttgcggttca ttctgctttg cttgtacacg ccggaatttt 2083921 tggctgtgta tttttgcctg ctccacagtt ttaagcccat ttttcttcca ttcaaacaaa 2083981 atccggtcaa tgtagcggaa actgagtttt cctgatagta cagcctcttt taacgcgtgt 2084041 ttgatcagtt gtgcgtcatg ctgatcctgg tcctgccaga tcgccagcgt ttcacactcc 2084101 aaaggcgata acggtcttgc gaactcttcc tcaaaaatgg tataaaggct tttttgttcc 2084161 ccttctgctt ttctttcctg tgtttgattc tgtgcaagct gaatatactc gtacagcttg 2084221 ccccataaag gctgaagaga atatttctca aatttgatgc cgttttgatc ctcgcattct 2084281 tcaataaaca gaaagccttt ttgaataaac atccgcaatc tgtttgtaca ttcttcaaca 2084341 gaaattgaca taccttcctg cagctgattc ggtgtaggaa aatatgatcc tttttctaaa 2084401 tgcattttaa tttttaacag cagaataagt tctgtttcat taagcccaag ctgtttataa 2084461 tgcgtgagca gaagattggg gatggttgat gttccctgct cctgcatatc aataaattgc 2084521 tgttttttca tcgtcacacc tcttactgta aaggattgtg attgcccctt tactgtaaaa 2084581 agtctccctt gcaggagact cttttttgtt tcatttgaat gtattacgga tacagacggt 2084641 ttaacagtct tgggaacgga atcgtttcac gaacgtgagg cgctccgctg atccaagcta 2084701 ctgtccgctc taatccaagg ccgaagccgg aatgaggaac tgatccatat tttctaagtt 2084761 cagcatacca tttataagcg tcagaatcca gtccatgttc tttaagacgc gattccaaaa 2084821 gttccatatc gtgaatccgt tcagacccgc cgatgatttc tccatagcct tccggcgcaa 2084881 tcaagtcagc gcaaagcaca acgtcctcac ggtcagaagc cggctgcata tagaacggtt 2084941 ttaaggacgt cggatagcga gtgatgaata ccggtttgtc ataatgttca gcaatcgctg 2085001 tttcatgagg cgctccgaaa tcatctcccc actcgatatc gtcaaagcct ttttctttca 2085061 gaaattcaat cgcttcatca tacgtaattc ttgggaacgg ggctttgatt tgctcaagtt 2085121 ttgacgtgtc tcttcccaat gtgtttagtt caattttgca atttttaaga actgattgca 2085181 cgatgaaaga aacgtaattt tcctgtactt gaaggttttc ttcaaattct acaaacgcca 2085241 tttccggttc gatcatccag aattcgatta agtgacgctt tgttttagac ttttccgctc 2085301 tgaatgtcgg tccgaaagag aatacttttc ctaaagccat tgccgcagct tccatgtaga 2085361 gctgtccgct ttgagacaga tatgcatctt catcaaagta ctttgtcgca aagagttctg 2085421 ttgttccttc aggtgcgctt ccagtcaaaa tcggcggatc cacttttacg aagccttcgt 2085481 tattaaagaa ttcgtaagtc gcgcgaatga tttcattacg gattttcatg atcgcatgct 2085541 ggcgctttga acgcagccat aaatgtctgt gatccatcaa aaattccgtt ccgtgttctt 2085601 ttggtgtaat tggataatcg gtcgcttcgt gaatgacttc aatatctgtc acagcaagtt 2085661 catatccaag cggagaacgc tcgtcctctt tgacaatccc ttttatatag agcgacgttt 2085721 cctgcgtcac tgatttagct gtttggaaaa tgctttcttc cacttccgct tttactacga 2085781 caccctgaat aaaaccggta ccgtcccgaa gctgtaaaaa cgcaattttc ccgcttgaac 2085841 gcttattagc gacccaagct ccgatcgtta cttcctcacc tacgtgcttg tacacttggt 2085901 tgattgttgt tttcaacata tttccctcca aaacaagaaa gacattcgga agctcattgc 2085961 cccgcgaact cttttatcat cactttatta tacccgctct taactaaccg ggtcaatgca 2086021 gataaaaagc ggcttttctg tcagccgctt tttgatctgt tagctatgtt tttctacaaa 2086081 acgcttgatt ctttcaatgg cttcttcaag aagatctaac gatgttgcat aagaaagacg 2086141 gacattctca ggagagccaa atccggatcc tggaacaatc gcaacttttt cctcctcgag 2086201 aagcgcttta acaaattcat ctacatcttt gaaaccgcaa gattgagctg cctcttttgc 2086261 atttgggaac aagtaaaaag caccttccgg cttcacgcag ctgaaccctg ggatttctat 2086321 gagctttgca tagatcgtat ttaatctatg ttcaaatgct tctctcattt cttccaatgg 2086381 ctcagaaggc ccgttataag cagcaatcgc tccgtattgt gcgattgatg tcgggtttga 2086441 cgtgctgtgg cttgcaaggt tcgtcatcgc tttaataatg tcttcagagc ctgccgcata 2086501 accgattctc cagcctgtca tgctgtggga cttcgatacg ccgtttataa tgaccgtttg 2086561 ctctttcagt ctgtctgaca gctgtgcaat ggaaacatgt ttctttccgc cgtatgtaag 2086621 tttttcataa atttcatctg acacaatcaa gatatcatgt tcaaggcaca cttcaccgag 2086681 cgcagatagt tcttcttccg tatacatgac accagtcggg ttgcttggag agttaataac 2086741 gattgctttt gttttttccg taattgcatt tttcagctgc tcaggcgaaa ttttgaagtg 2086801 attttcctca agcccttcta cataaacagg ctttccgcca gcgagtttca cctgctccgg 2086861 gtagcttacc cagtaaggcg ttggaataat aacttcatct tcttcatcca aaatcacttg 2086921 gaaaagggta tacagagcat gtttggcacc agtgcagaca ataatttgag acggtttgta 2086981 ttcaatattc tggtcgcgtt taaatttctc tgcaatgctg tttttcagtt cagccaaacc 2087041 accggaaggc gtgtatttcg tatggccctc gttcatcgaa cgcacagcgg catcaataat 2087101 atgctgcggt gtattgaagt caggctcgcc tgctcctaag ccgatgacat catggcctgc 2087161 ggctttcagt tctttcgctt tcgctgtgat tgccagtgtg gttgatggtg ttaatgcgga 2087221 tactcttttt gccagtttca acttgaactc cccctaattc gtcttaaggc gtgatatttt 2087281 tgagaatctt tccagttgta aagtccacat aacttaaact gtattgccct tctttgtcta 2087341 agtacgtcac ttcccaaagc aggacgtttc cttctcttgc cagatgaacc tctttttgct 2087401 ttgaaaccag cccttcatcc tttatgattt tcgccgcttt gtcttcagag attccctctt 2087461 tcgcttcttt tgagagaatt tttgcttttt tatcagcagg aacccagaca tataatgcag 2087521 tgcctttttt atccgttccc tttacaacat aatatttttc ttttccgaca aatgtttcga 2087581 cttgatcaac atgggcgaga tcggtttctt ttttagcttc agcagctgct gcttcgtgcc 2087641 cctcttcctt ttgtgccatg gctgatttat aaatgcttgc cgagacaaga agtactgcta 2087701 aaaaaataat accaaaaatg acggtaaata ttaatgcttt ttttctcatc ttctcaccta 2087761 cgtacgataa atggtaaaaa cggcttggtt tttgttttct tcatccagcg caaggccgaa 2087821 catcagattg tctcttttca gtgtacgatt caatgtgtcc acaattttat acagatcatc 2087881 agaatgctct acattaattg ttgaaagaat ttcgatttta ctttccattt tttcatcctc 2087941 cagtttgaac aaatattgtt agtcatactc catttcagga cacgccatac tagtatcaca 2088001 gagcgggaaa tccgctttta aataaaacac catcctactc ccacaccgca aaagccgctt 2088061 tatgcggctt ttattctttt tcccctgcaa cataagcttc aagctcgctg tcagtcattt 2088121 cggatactga ggttgtcggc aaggcatcaa gaaacagccg gccgtaacca gcggttttaa 2088181 tccgtctgtc caatataata atcgttccct tgtctcccgc agaacgcagc aagcgtccga 2088241 ttccttgcct gaaggtcagc acagcttccg gtaatgacac tgtttgaaac ggattctttc 2088301 cttttttgcg ggcaagctca cattttgcag catgaagcgg gtgatcaggg gaccggaatg 2088361 ggagcctcac gatcattact gtcgtcagct catcaccagg gaaatcaacg ccttcccaaa 2088421 aatgatttgt tccgagcagg atcgcctgat tggatgtttt aaaagtcttc atcagtttgc 2088481 cgggacttcc gcctgtaatc ccttgtgcca agagctgaat gccggaagca ctcatgttat 2088541 gcttaagctc ctggtgaacc tttttcagca tatcatggga tgtaaacagc acaaggattt 2088601 taggctgttt ttcctttgcc atcagttcga tataacgggc tgtatcctgt ataaattcag 2088661 gttgccctgt atcctgaatt gatttcattt cttttggaat catcacctgc atacgctcat 2088721 cgtaagaaaa gggtgactca attctcattg tccgcgggaa aaagtcactc agtcccagtc 2088781 gttcaatcat aaattgaaaa gaaccttcga ctgtaagagt tgcagatgtc agcaccacac 2088841 tatttttgcg cgcgaaaaac tgatcagcca gaagttcacc aggttcaaga ggctgtgcgt 2088901 aaatggccac tgcatttttc gcaccctttg catctatttc aatccaaacc gcttcatcgt 2088961 catcagagcc aaagaagagc ttctgcaacg tctgacagta atgctgcaag cctttcatgc 2089021 ttctttggta ttcatcggct aaaaagacgg ttttgctctt catgcccttc aaatgttttt 2089081 ccataaggga tgactgcgcc tcaaaaagct gctgcaaatg tgtcagcatg gaacaaagcc 2089141 tctccgcacc atctgttaag atcgaccagc ttttatcctg gctttctttg ttcaccttaa 2089201 acactagacg gtttaagtct tctttaggtt ttcttcgttt gacaaaagaa tgtacagagc 2089261 taaagaaagc atcactttct gcttgaacgt gctgaagcca ctcttccaat tcgaaaaatg 2089321 aatcaaccgg caggctgttt cgctggaata gctgtctcat cttttttaga agtccctgct 2089381 ccttcagagt gccgattctg ctcaatttcg tatgcaattc tatgtacgtg gctcttttcc 2089441 ctaaatgttc gcttgccgca cgttcaaaat ggtgtgcttc atcaataata aatgtgccgc 2089501 tttcgggaag ccttttttta tggctgcctt catcggtcag caaaagagaa tgattggtga 2089561 tcaccaaatc ggaacgcata gcaatctgtt tggcccgctc gtaaaaaccg atcacatgct 2089621 cactgcgact tcttttatag gagtcatcgt cataagccaa tctgtcccac agcaattttc 2089681 cgcctgaagg caaattcagt tccgctacat ctcctgtatt tgtctctgtc agccaaacaa 2089741 gaagctgtgc ctttgtcagt acggcatcat aattatcatc ttcttcatga agcacctgct 2089801 caaatttata caggcataaa taatgcgatt gcccttttaa aatcgccgct gttaccggaa 2089861 atggaaacag atcttggaca atcggcaaat cctttgtgag aatctgctgc tgtaaaagcg 2089921 tcgaatacgt gctgattatg accggctttt ttgatttctt ggcaaaaagc gcagccggaa 2089981 taagatagcc aatcgttttt ccgatgcctg gaggagcttc aatcagcgca tgctcacgat 2090041 tggcaaacgc atcagccacc tctctcatca tcatcatttg gccgtctctt ttttcatacc 2090101 caggcattaa ctctgacagc gctttttcat ttcccgcttc ccagctttcg atctcaaatg 2090161 agaagttctc gtcctcattt atacgaacat cgatagcttc aggttctctg acagaaaacg 2090221 aagaaaagcg cgtatagccc ggtatctcgg tatgtctgtt ttcattaatg aacatatcca 2090281 acaaatgcgt cagatcactg atgaaatgct gcgaaagcct tcttaactgc tttaatgtcg 2090341 gataaggaag ctgccgcagc ttttcaagga tttccaaaaa aataagccct gtcacttcag 2090401 catcgctgtc agcccggtgc ggctgatcat gccgcagctg aagctcctcg cttaattccg 2090461 tcagcttata cccttcaaat cccggaaaaa caatgcgtga gagctcgaca gtatcaagca 2090521 cttcacaatc tgggagctga aagcccgcct tatgtagctc atacttgaca aatccaaggt 2090581 caaaatggat attgtgggcg acaaaataag cgccgtcaag caattggaat acttcttcag 2090641 caactgcttc aaatggctgt tcattctcga ccatttgatt agagattcca gtaagctgct 2090701 caataaaagc agggattgat ttatttggat taatgtattt tgaaaaccgc tcagtaattt 2090761 gtccattttc gattacaacc gctgcgattt gtatgatttt atcgcctttc ttcggcgaat 2090821 tccctgttgt ctctacatct ataacaacga accgttgctt attcattaaa atggacacct 2090881 caattcttgc atacgacaaa agtgtaacac gttttgtacg gaaatggagc ggcaaaaccg 2090941 ttttactctc aaaatcttaa aagaaaaccc ccgataaagg gggcttttct tctacaaaat 2091001 tgtacgggct ggttcgttcc ccagcatttg ttcaattttg ttttgatcat tcagaacagc 2091061 cactttcggc tcatggcttg ccgcttcttg atcagacatc attttgtagg aaataataat 2091121 gaccttatct ccttcctgca caaggcgtgc ggctgcaccg tttaagcata tgacgccgct 2091181 tccccgttta ccaggaataa tatacgtttc aagacgtgct ccattattat tattcacaat 2091241 ttgtactttt tcattaggaa gcattcccac agcatcaatg agatcttcat caattgtaat 2091301 gcttcccaca tagttcaggt ttgcttccgt aacagttgcc ctgtgaagtt tgccgctcat 2091361 cattgttcga tacatattat attctctcca tttctcgaat atcaataatg atattatcta 2091421 ttaaacgcgc ttttgaaaaa gcaactgcaa cagcgagaat catctttcca gcaatttcat 2091481 tcacaggctc gagttccgga taggaataaa gctctacata gtctatggtt ccgctagtcg 2091541 tttcaatgat atcttttgca gcttttatca ccgcttcagg atctctttca ccggcttgga 2091601 caagttccgc acttgtttga agggcccgat acagcttagg cgcttctttt ctttcctcag 2091661 ctgttaagta tacattgcga gagcttttgg ctaagccgtc ttcctctctg accgtatcga 2091721 caggaaccaa ttcaatatcc atgaagaagt cgctgattaa cccatcaaca acagctacct 2091781 gctgcgcatc ttttaaaccg aaataggcac gagtcggctt gactagattg aaaagcttcg 2091841 tcagtacgat cgcgaccccg tcaaaatgtc cttctcttga gcgcccgcat aacacgtctg 2091901 tgcgtctttc tacatgaatc gtgacattct tttcaccggg atacatatca tgagcatctg 2091961 gcgtaaaaag aatatcgact ccggcgtttt ctgcaagagc tgcatcccgc tcaatatcgc 2092021 gcggatatgc ttcaaaatct tcattagggc cgaattgtgc aggattcaca aaaatactca 2092081 taataacggc gtcgttttct tgtcttgctt tgtctgctaa ggttaaatgc ccctcatgca 2092141 gaaaccccat cgtcggaaca aatccgattg acttgccctc tgaatggtat tgttttatgg 2092201 cttctttcag ctgtgaaata tcagtaatct gtctcatctt attttccccc gtacaagccg 2092261 tcaagcactg tctggttcat ttgaaaggaa tgcttttgtt cagggaaagc acgatgtctt 2092321 acatcctgaa catatccgct gattgctgtt tcgatggttt catcaatgcg cgtatattgc 2092381 tttacaaatt taggtgttct ctcaacaccg tggccgataa tatcatgata aacgagaact 2092441 tgtccgtccg ctttcacacc agccccgatt ccaatgaccg gtatgcttag cgtctcggca 2092501 attttggctg tgagttctgc cggcacacat tccagcacaa gcatcatagc tcctgcttct 2092561 tcgcatttta tactgtcttc tattaatttt ttggcgcttt gttcgtcttt gccctgtact 2092621 ttatagccgc ccagtacgcc gactgactgc ggtgtcaaac ctaagtgact gactactgga 2092681 atgcctccaa gcgtcaatgc gcgaatggat tcaaacacgc cttctccgcc ctcaagcttc 2092741 agtgcgtcag ctccgctttc ctgaacgata gccgctgcat ttttcagcgt atcttcctta 2092801 gacaggtgat aagacataaa cggcatatct gtcacaataa aggtattcgg cgcacccctt 2092861 ttaacggctt ttgtatgatg gatcatgtcc gcaactgtca caccgacagt tgaatcaagg 2092921 ccgaggacga ccattccaag tgaatcaccg actaaaatca tgtcaactcc cgcttgttca 2092981 gcaagtttag ctgccggata atcataagcg gtcagcatga caatcggttc ttcagactcc 2093041 ttcattttta gaaaatccag ttttgttttc atgttttctc ctcctcatgt ttagaggaga 2093101 tgatctgccg ttttcttctg caagccaaaa aaccttccgt tacaacgaga aggattcttc 2093161 actttctaaa gttcggcgag tttcatccct ctgtcccagt ccttttttgg atcaaggcag 2093221 actgctgcaa tgtctatcta ttttaataat aggtgcagtt cgcaggcgat actgcccaat 2093281 ggaagtatac caaaatcaac gggcttgtac caacacatta gcccaattcg atatcggcag 2093341 aatagatttt tttaatgcct tcgttcgttt ctaaaagcag aacgccttca tcatctatac 2093401 ctaacgcctt accgtaaaag gttccgttta acgttctggc tctcatatta gtgccaatac 2093461 cgagcgcata gctttcccat aaaagcttaa tcggcgtaaa tccgtgcgtc atataatccc 2093521 ggtaccgttt ctcaaagcat agtaaaatat gctggatgac gccggcccga tcaatttttt 2093581 ccccagcagc ttggctgagg cttgtcgcga tgtccttcaa ttcatctgga aaatcattag 2093641 gctgctggtt aacgttaatg ccgatcccaa tgatcactga acgtacgcgg tcttcttcag 2093701 cctgcatttc cgttaggata ccgactgttt tttttccgtt aatcaaaata tcatttggcc 2093761 atttaatatc cgtttggatg cctgctgcct cttctattcc ctgcacaaca gctactgcag 2093821 caagcagagt cagctgcggt gttttttgga gcggaatgtc aggccgcaaa atcaggctca 2093881 tccaaacacc gtttccttct tgagaatgcc ataccctaga cattcggccc cttccggctg 2093941 tttgtttgtc agccaccaca agggtgcctt ccggtgcgtt attattcgcg agctcatgag 2094001 ccgttttttg cgtgcttgaa agaacgtcat ggtaaataag atgctggccc atcacttccg 2094061 tttttaatcc aaaacgaatt tcgctttcac tgagttttcc gggttttttg atgagccgat 2094121 atccttttct tctaacggct tctacttcat aaccctcttt ccgaagctct tcaatatgct 2094181 tccacacagc agttcttgaa cagccgagag catcactgat tttttggccg gaaataaatt 2094241 cattgccggc ctgagaaaat aattcaataa ggtcttttct taatgttgac cgcatgtctt 2094301 cagccactcc tctatgtgtt tcttttgatt ggagagcttc cctgtcacaa cagcctgctc 2094361 gatccactgt aattcttctg acacccattt tccggccggc cggtttcgaa gcgcaagcaa 2094421 gtccttaccc gtgatatcaa gatccttaag gcttttgatc ggcaggtttt gataagcgta 2094481 ctgaatgtcc ttcagtttct tttcatccag tttttcgttt tgccgaagct gcgatatttt 2094541 ggccgctgag agcagtgctt ttttcccagc tctgtacatt gtcattgcgt caaggctctg 2094601 gccaaacgta tcggcaatgt gaatggcttc cttgatcact tttcccggga gcttccaggc 2094661 tttcaggaaa aggggcgcgt ctttcaaaac tatgccaagg ttaattaaaa gagcagccca 2094721 aagctcctca cgggatgtta aagagaagaa tggaaactca ctcgttgaaa tcaggttttc 2094781 tcgtttatga taaaaaccag gaagctcttc atacaatctc gtttgaatga gtgtttgaag 2094841 cgcctggcga gaagctcttc cctgcagcaa tttctcaaac tctatagttt ttcgttcgac 2094901 tgaaacatgg gagaggagtg atttttcttt cgcaatggct tcttctgttt ccggtgaaag 2094961 cgtaaagcca agctggctca taaagcgtac ggctctcagc atacgaagcg catcctcttg 2095021 aaatctatcc tcaggctttc caacggttcg aatcactttc tgatcaatat ctttcttgcc 2095081 gccaaaataa tcaagcacct tcccgtccgc tgtcatggcc atcgcattga tcgttaaatc 2095141 tctgcgtttt agatcctctt ctaatgatga gataaattgc acttctgacg gtcttctgaa 2095201 atcaacataa tcagattcag tccggaatgt cgtgacttca taggtttcat cctcccagag 2095261 cacaataatg gtcccgtgct ctttgcctac atcaacagtc cgctgaaaca gccgttctac 2095321 ttgatcaggt gccgcatctg tcgcgatatc gacatctccg atcgttcgtt tcatatagct 2095381 gtcacgaact gcgcccccga caaaataagc ctgatggccc gcttcgatta agatgcggag 2095441 cacgggaagt gctttgataa aaactttttc catgtgatca ctccggttct gctaaatcgg 2095501 cataaatctg ttcatactgg ctgacaattt ttttagaaga aaattcattt tcaagcatct 2095561 ctattgccgc ctttgtaaaa cgattgctta gctgttcatc ttctaaaatg ctcatcgcgc 2095621 gggctgttgc ggccgtaaca tcaccgacat ccaccaaaaa tccgctcaca ttgtttttta 2095681 taacctcagg gataccgcca atgtttgttc caatacaagg cactccgcaa gccatcgctt 2095741 caagcaggac aaggccaaag ctttcttttt cagatagcag cagcttcaaa tcgctaatag 2095801 aataaagatc ttcaacacgg tcttgatttc caagcattaa gacttggtct tccaagccat 2095861 attttctgat aagctcgcag gctgtcgatt tctccggacc gtctccgact aaaagcagct 2095921 tcgctttcgt tttgccagcg atattgcgga acacacggat gacatcctgc acgcgtttaa 2095981 cttttctgaa gttggacaca tggatgacga ctttttcatc tggtaaaatt ccatgtttct 2096041 ctttaattgc cgctgtgttt ttcttcagat acacgcgctc gtctataaag ttataaatcg 2096101 tttcaatttt tttctccggt ttaattaaat cgtatgtttc agccgcaagc gctgaggaga 2096161 cggccgtcac cctgtctgat gactcaatag caaaacggat cagatctttt agagacggat 2096221 cataacctaa caccgtgata tccgtgccat gcaaagtggt aacaatgccg atattgcgtt 2096281 tcagcatttg ttttgcaaga taggcgcaaa cggcatgcgg gagagcatag tgagcatgga 2096341 taatgtctaa attctcccgt tccgccacct cagcgatttt gcttgccaat gtcaaatcat 2096401 acggaggata cttaaaaaca gcatattgat taacctcaac ttcatgaaaa tgaatattgg 2096461 gatgatatgt attcagtcta aacggaatgc ttgatgtgat gaaatggatt tcatgtccct 2096521 tttcagcaag ctgcttcccc agttctgtcg caatgatacc tgagcctcca acgctcggat 2096581 agcatgtgat tcctattttt agttttctca ttgttcgccc ccaagcacat catgatcaag 2096641 catcagcatc cgtttggaaa agaaaccttc ggcatactcc acgcccgctt ctttaccgta 2096701 aagcttttct ctcgcttcaa cgatttcaat atacccattc gtcagaggag tagaaacgga 2096761 atcctttgac gggataaact ggcttttgta ggcgttgagg ctttgtttct ttgcctctat 2096821 tgtatccgag atatcaataa caaaatccgg ctgatgaaaa ccatttatca tataatagta 2096881 aaccttgctg actttatgcg ccggaaggct tttttcgtct ttatatttat ggattccggc 2096941 ggaaaagatc gcttcttcca ccagtgcagc cgcattgccg tgatccggat ggcgatcctt 2097001 tttatacggc ataaaaaccg cttttggccg acagattctg atgacagtga caattgaccg 2097061 aattgcctga tcactcatta ttaggccgcg gtctggaagc gttagctgaa ttcttttatc 2097121 tgcgcctaat atgcgggctg cttcagctgc ttcttcttta cgcaaactga ccgtaccgtt 2097181 agaagagagt tccgcttctg tcaaatcgca tatcattact tttttttcct gtttgacaaa 2097241 cttcgctatt gtgccgccca ttccgatctc gacatcatca ctgtgggcgc caaaagcaag 2097301 aacgtcagca ttatacattc ggctcttctc cccgaagaag gtcacggaat tcgaaaacac 2097361 cttcatcaag tgtgcgcaca agaatttccg cagtacccat atttgtggcg agcggaatgg 2097421 aatacacatc acataaacgg attaatgccg agacatccgg ttcatgcggc tgcgcggtca 2097481 gcgggtcgcg caaaaaaatg acaagatcga gtgcattggc agcgatcagt gcaccgattt 2097541 gctggtctcc ccctaaaggg ccggattgaa aacgttcaat ttgaagacct gtcgcctcat 2097601 gaattttcaa ccctgtggtt ccggttgcgt atagatcatg attctttaaa atatcccgat 2097661 aggcagtcgt aaattgaacc atatcctgtt ttttcttgtc atgcgcgatc aaagcaattt 2097721 tcattgttta tccccccgtc taatcaatga tattttctaa accatacaca agctgatcaa 2097781 tcttcatgac ttgttcgact gacagtttaa cgcctgacat gaaagaagca cggttataag 2097841 aatcatggcg tatctgaagc gtttggccat ccatgccgaa catgacctcc tgatgcgcga 2097901 tcagtcccgg aagacggacg ctgtgcaagc gaataccgtt ttgctccgct cctcttgctc 2097961 ctgggagaat ttctttttca tccggatgtc cttgctgctt ttctttacgg acttctgaaa 2098021 tcatttccgc tgttttaagc gcagttccgc ttggtgcgtc aagcttctgg tcatgatgaa 2098081 gctcaataat ctcaacatcc tcaaaatagt tggcagccat ttttgaaaat ttcatcatca 2098141 gtatcgcacc gagcgcaaaa tttggcgcga tgatggctcc gatccctttt tcttctgtta 2098201 aagatgtgag ctcttttaaa tcagcttctg agaaaccggt tgttccgaca actggacgga 2098261 ctccgtgctc taatgcaatt tttgtatgta cttttccgat ttcgggcgtt gttaaatcaa 2098321 tcaagacatc cggttgtgtt tctgtaaaac aggcatggat atctgtgtaa atgaaagcat 2098381 ctgactcaac aggcatcaca tcagataatt tttgctgatc gtatgtatgg tctatggccc 2098441 ctacaaggtc aaaatgtggt gttcgttctg ccaatttaac agcttcctgc cccattcttc 2098501 cacgcggtcc cgcaatgact aatttaattg tttcgtttga catcttgatc tcctctactt 2098561 tccttcttct tttctggtcc agcgatcttt atctcttgta ttaaatttat gcatgactcg 2098621 gtcgtgagct tcctctaaag agatatcaag agagttggct aaacaaacca atacaaatag 2098681 cacatcgcct atttcctctt ccatgctttt atcatcttca gtcgcttttt ttggtttttc 2098741 tccataacgg tgattcactt ctctggcaag ctcgcccagt tcttcagtca gcctcgccat 2098801 catggccagc gggctaaaat atccttcttt aaattggcct atgtaacggt ctacttcagc 2098861 ctgtatgtct ttcattgttt tatcactcac tgaacgaaac ctcctatcat cctcttacat 2098921 gttagctaat tcagatacgt ttgacaaatg tttaagcacg tttgctgttt tctttttcat 2098981 ccactataat ataaacgcta tctaatggaa ggaaaagggg ttttgtgtga tgcttggaga 2099041 aattagatta aaaaacatat tttttatttt aatcggagcg gcaatttttt catttggctt 2099101 ggttcatttc aatatgcaga acaatctggc tgagggcggt tttacaggta ttacactttt 2099161 gctttatgcc cttttccaca tcagcccctc tatatcgaac ctggtgttga acattccgat 2099221 tttttttatt ggctggcgtt tgctcggcag gacaatgttt gtttataccc ttgtcggcac 2099281 tgtagccttg tctttgttcc tcagcatctt tcagcgatat gaaatccata tgccccttca 2099341 gcacgactta gcgctcgccg ctttatttgc cggcgtattc atcggagccg gactgggtat 2099401 tatttttaag ttcggcggta cgacaggcgg tgttgatatc atcgcacgtt tagtgaataa 2099461 gtattttggg attccgatgg gcagaacgat gtttgctttc gatgcctgcg tcatcatttt 2099521 gtctttgctt acttatctct cctataaaga agcgatgtat acgctggtag ctgtatttgt 2099581 agcggcaaga ttaatcgatt ttattcagga aggcggatac gctgctaaag gcgctacgat 2099641 catctcttcg aaaaacgacc tgattcagaa aaagattctt gaagaaatgg aacggggcgt 2099701 caccattttg aaaggacaag gttcctacac aaaagaggat atagatgtac tttattgtgt 2099761 ggtgccgaaa aatgaattgg tgatgctgaa aagcgtgatt aactccattg atccccatgc 2099821 ctttgtagcg gtaagcgatg ttcacgatgt gctcggagaa ggatttacgc ttgatgaaaa 2099881 taaaaatccg cttccgcgct gacatgtaat agaaaaaagg cggctgaccg ccgcccctca 2099941 tccttattta gggtagtccc tttttttcag cttgtttttt tccgccttgt actttctgta 2100001 accgacatag gtaagagcag taatgatgat actgccggtt gtaatgatca cccagagtaa 2100061 agacggatcg gcatcatcct cctccaccct gtcaaacaca tttttcaggt catgctgaag 2100121 aagggaaagc cgttcaagct tcgtgctctc tgtcatttgc tgaaattcct cttgctcaat 2100181 aacatctata tgttttccga ctgtttcaag ctgatcctct gatacatcga ttgtaagact 2100241 ggggtaaatc aagtcatata aactgataaa ttcattccat ttttcatgaa agcttgtgct 2100301 tccattcttt tggacatctc gcttcagttc agtaaaagct tccataatcg gtttttccag 2100361 tgagccccaa agcgggtcag accgattgtc aaccgcatcc atcagcattc tgaactgcgc 2100421 ggctgctctg agtttttgtg tgtctgatgt atcagcttgc tttaaactcc gaaccatatc 2100481 attatagccc aatgtgattt gacgaatttg ggctcccgtt agcatggggt cttgctgttt 2100541 tttctcagcg gattttaatg ttttttcaaa atactccaag acttgaagcg cctcttcata 2100601 tttcgcctgt cgggtcattt gaaagactgt atcggataaa tcattcaatt cctcgaggct 2100661 tccccgctct gcagccttgg catttccatt ataaaaaata agtgcaatca acaaacagat 2100721 cgtcagcttt cgtttcatgc aggtccctcc cactctctct ccttacagaa tatgaagaaa 2100781 gggacaagga tagaccaaca ttgtctttac atcagctcaa gcttcgtttg cttttttgag 2100841 accacaagaa agtaagcaag cgcgattgaa aagatactta gccaaaatgt tccgtatcct 2100901 atttcagtca tataatcaga aagcatagag tattgcggca tcatatcaaa caagtagtca 2100961 atgacatcgt tatgcagtgt ccagactgca gcaattgcaa gatgccaaaa tgaaaaacga 2101021 aaatacggac tgtataatac gccttgaact gccattgcaa aatgcgaagc aattagcatg 2101081 tagccctccc acggcaagtc accagttact gcaagcacaa gaaaattcat agccaccgcc 2101141 cataggccat actttacgag ggtaactagc gcaagcgcct ctaaaagcgg agcattccgt 2101201 ttcatgagaa aggcaagcag cacaaacaga aagaaaaacg ttgctgtcgg actgtccgga 2101261 acaaaaatca ggaaacgggc cggtgtctcc aaaagctgcg gcaagtacca atagtagccg 2101321 taaaccgttc ccagaaaatt aatggctaag acaagaataa gcatcggccg ctgccctaat 2101381 acatattgaa accatttcac atcgaatcaa ctctcagtct gtaaaaataa tatgtccata 2101441 taaaaaagct gacgccgggt cagcttttga taataaaagt atatccttcc atttgacaat 2101501 tcacaatacg ttattttgcg gttgtttcag aaataaattt tgcaagttct tcgagctgct 2101561 tatcatttcc tttgaacaca cccgccggca ttttgccttt cccttctaca gcgatttttt 2101621 tgatttcatc cggtttcagc ccgctgtcaa ccaatgaagg cccggccgct cctccctgaa 2101681 ggttatcccc atggcaagaa atacagccct gttccttaaa aaccttatat ccttctgcat 2101741 tggtgtcaat gtcggcttct tttgtaattt tcccctgttc ttctgccttg gcccagtcat 2101801 gagtagcaac tgactgccac gtcaaaaata cagcagcgga aatggccaga agcatcatac 2101861 cgacagcgac cggacgcttc cacggccttc tttctgtccc tctgtctagg aatggagcca 2101921 aaagcagggc cccaaaagcg agacctggca taatcatggc gccgaccact gtaaagcttc 2101981 cggcggcgta ttcatacttc aacagctggt ataagaaaag aaaataccaa tccggcagcg 2102041 gaatataacc agtatcagtc gggtccgcca tccgctctaa aggcggctga tgcacaatcg 2102101 tcaaaacgag aaaaccgatg agaaagacag ctccaaccat ccattccttt aacaagaaat 2102161 ttggccagaa agcctctgtt ttacccggat actccgaata atccttcggt atattcggct 2102221 ttttttcagc cggtatcctt gagtcgccta caaatttcat ccctttgccc cggtgcatgt 2102281 catcccctcc cttttattcg cagatcaaga gtttaaagcg gtcctgaaat cccctgcttc 2102341 cggatcataa taaaatgtgc agccatcagc ccgaacaatg cggcaggaag aaaaaataca 2102401 tggatcgcaa aaaacctagt cagcgtttgg gcgcctacaa tatccggatg ccctgcaagg 2102461 agcgttttaa cttgcgttcc gatcaaaggc gtggcttcgg cgatctgcag tccgactttt 2102521 gttgcaaaca gagccttcat atcccaagga agcaagtagc ctgtaaagcc aagaccgagc 2102581 ataacaaaaa agatcagcac accgacaatc cagttcagct cgcgcggttt tttatacgcg 2102641 ccttggaaaa agaccctcag cgtatgtaaa aacatcatca caatgaccag gctcgcaccc 2102701 cagtggtgca tccccctgac aatctggccg aatgccactt cattttgcaa ataatatacc 2102761 gattcccagg catttttgat atcaggcaca taatacatcg ttaaaaacat tccagataat 2102821 acttggataa cggttacaaa aaacgtcagt cccccaaagc aatacacaaa cgcagagaaa 2102881 tgatgggcgg gattcacatg ttccggtact tcgtgatcgg caatatccct ccacatcggt 2102941 gtaatatcaa gccgctcgtc tacccagtca taaattttgt tcagcatgtc acccttcccc 2103001 cttaggcttt gcttttccaa gatacaggaa gccgtctttt acttcttgct cataatgatc 2103061 aagaggcgca agcggcggcg tgccagggac attggtgccg tccttttcat agagtccgta 2103121 atggcatgga caaaagaatt tattcgggtt tttaggatca ctattccagt tcaccgtaca 2103181 ccctaaatgc ttacaaattg gcgaaagtgc tacaatttca tccccgtttt tgaagaccca 2103241 ggctgatctt gactcttctg actcatacca ggcatcgact tgattaattt taaaatcaaa 2103301 gcgctgcggc tcttttgtca actcatcaac gctgacaacc tgaaccatat cctgcttccc 2103361 tgtcgatttt aataccgggt cgagtgcgaa gcgaaccata ggcatgagca tactagccgc 2103421 cataaaacct cctacgcctg tgagcgtata attcaaaaat tgacgtctgg atatatcatg 2103481 ttttccgccc atctcttctc ccccctctaa gtcacccctg caaactgact aaaatagaaa 2103541 atattgcaat aactctagac accctcataa tatatgaatc tctcagcaag gtcaatatag 2103601 ccaaaatatt gtttataagg aaatgtaagt gtttttataa agtgctccat aactgtaaca 2103661 aaacgttcaa aatttcagca gtgcgttcat ccaatatttt tctttttaaa gagtcattta 2103721 aatgctctaa tggaacagac gatgtaacaa tcattttgcc taacgcatcc tcagctctcc 2103781 aactttcgtc agatgtgagc aggacaacat gcggaaattc cgttatcagc tcttcccgca 2103841 aatccttaag cccttgaacg gttatttcat ttctatcaac atatgtataa ggcggaagta 2103901 aatatacccg tccctttaac tgcctttcaa gttcttctga gagaagctgc gtaaactcgc 2103961 ctttctccgc cgccatttta aaatggttat taacccttat gttaattaat ggtatgacag 2104021 cggtatcaat gtaatcctta gcttgtaaat agtccttggc atcagtgatt ctccacctca 2104081 tcgttctccc cctttacggc aacaagcctt gcaattcact gcaaggctgg tcatattatg 2104141 tgagctgatt taattggcgc gataattgtt caaatgcctc tttatcatga cgatctaacg 2104201 cgtcgtcaat gtcttttaat aatttttctc tttggaatgt ggaaatagcg tgctctaaaa 2104261 tctgttccgc caatccctga tcttttttat tctcaaaaag gtttttcgga atatgcgggt 2104321 tggactccag caccgccgca tattcaggtg agctgtaagc cgaacggaaa ttaagctgga 2104381 taaacaaatc ctgctgttta tttaatctaa tatcatgaaa agatttttcc gcgtcggtag 2104441 tcatgacatt ctctttatag aaccggaacg gaacttcttc aacacaatgt gttgacatta 2104501 taatgcctct cgggcaaaat tcagcctgct ccacaaaatg aaccttctcc atgagagaat 2104561 catggctcat taagtagttc aagatccaaa cgcactctcg gcgctttaac tgataatggt 2104621 ttaaaaacca acggataaaa tcttttttct cattgacaga aacaggggtc tgcatgtaat 2104681 tccctcctct atcgttcgta taatctatat acttatatgt tccacatgaa tggttaatat 2104741 tcctgcttat ctagaaaatt catcctcgat tcgcaaaatc gtttcttcaa gctcttcatt 2104801 ggctccgtcc atttcaagaa cctttttcaa aagcggcagc gcttcttttt gaagaccttc 2104861 ttctaatagg aagcttgcgt attcatataa gaaatctcta tcctcccggt aatgaagata 2104921 ggcagcctca aaggattgtt ttgcttcctc gtattgctct aattcagtat atgcgcttgc 2104981 aagataccaa ttgtatttag gatcttcttc accgtagctt cgaacctctt gaataagatc 2105041 aatgatctga tcataatcct cttctttgtg atacacggca agaagtgtat gaagcgcctc 2105101 gacaaagccc ggatcaagcg caagcgcctc ctgaagcagc ttcttcccct cttctgactt 2105161 cccgattttc aaggccattt tggcggcata aaggaaaagt tctttgttat attcatcata 2105221 tctgatcccc tcttttgccg tttttaatgc ctcttcatac attccttcag cttcatagct 2105281 tttcgagagc ggcatataaa gtgaagtata agatggatca agctccttta aatcagacag 2105341 ctgcttaata gctgttttca caagccccgc ctgtaaggct gtaaaaccat agccgaaaat 2105401 cgtattagga tcaggattct catcgacagc tttctcatac catggaatgg catcctcaaa 2105461 ttcacctgag gcacttaacg attctgccag tctttgatgg acattaacgc ccccgatctc 2105521 actctgctcc tcagccgttg ttttaaaata ttgaaccgct tttgcatagg ctccctgagc 2105581 aaagtaaagt tctcccagtg caaaatcaat aacaggttca ttgtccagaa tggactttgc 2105641 ctggaaaagc ttttgttcac tgacttcgaa taacccctgc atctgataaa gatccgccat 2105701 aagcagcaaa ctttccggat atgatggatc tgtttccgga atagtctcca gcacagcgag 2105761 ggctttttct tcttcgtcaa tatctattaa aagttcagcg tagaaattcg tcagttctgt 2105821 ttcatttgga tataaatcat gtagatcact aatcagtgaa atggcttttt ctacatcgcc 2105881 ccactcgtaa taaagctggg ctgcaatggc tttatcttca tcatgcagct gtttttcagc 2105941 cttcgagagc gtgttgaggc ctttttctgt ttcacctgct tcaactaatt ttatggcttc 2106001 ttgaatcaat gtattcaaat cggaccggtc ctttcttttc ctatacaaca tcaaccatac 2106061 aaaaaaagct ttatttgttc gggttaatct tatcataatt cagacgaatg cccccggcaa 2106121 ataagatgct tctgtacgga agggaattat tgagtcttat tagtttacca aaagatcttg 2106181 agatagaaaa tgaaaaaagg aagatcgccc tctgtacagt aaagcagctc tttgacctgc 2106241 cggcttgtaa gtaaagcaca tccccccttt tcgtttttct atccgttcta taagacaagc 2106301 tatgtttttt cgcctcgaat tatgatctgc ataaaaaatc ctgaagtaaa acttcaggat 2106361 tttttcgaaa gcttatttaa atgctcgaag aaggttggat aagaaacgtg aatggcatcc 2106421 gtgtgctcga tttcaatcgg ctcctccgtt atacaggaag caataccaag catcattccg 2106481 attcgatgat ctccgtggct ggacactgca gcgccgcctt tcaacgtttg tttgccataa 2106541 accttcattc catctgctgt cggttcaatt tcagcaccca gcttgcgaag ctcagaaaca 2106601 acagtatcaa tacggtttgt ttctttcact tttagctctg ccgcgtcctt aataacggtg 2106661 gttccttccg cctgagtcgc aagaagcgcg atgataggga tctcatcaat taaacgcgga 2106721 atgatatctc ctccgatttc aactgccttt agagatgacg tttctataat caaatctcca 2106781 taaggctctg caccgctatc agcagatggt ttgatttcaa gttttgcccc catgttttga 2106841 aggacatcaa taatacctgt ccgagtcgga tttaaaccta cgtttttcaa tacaattctg 2106901 ctgtttggaa ccatcgcgcc agcagcaagg aaaaacgcgg ctgaagaaat gtctccagga 2106961 acaaaaatat cagcagctgt cagtttctgg ccaccagcaa tggaaacact cgtttgatct 2107021 tcagaaagct taacgccaaa agcagaaagc atccgctcag tgtggtcccg agatttatgg 2107081 ggctctgtta cagttgttgt gccctcagcc tgtaatccgg ccagcaaaac agcagattta 2107141 atttgcgcgc ttgcaacagg tgatacataa tcaattcctt ttaatgaagc gccgctcact 2107201 gacagcggtg taaactctcc gccggctctg ccgtcgattt tagcccccat ttttttcaaa 2107261 ggctcagtca cacgcttcat tgggcgtttc gcaatgctct catctccggc taccgcgctg 2107321 taaaaaggac ggcccgccaa tattccgagc atcaggcgaa tcgttgtacc tgaatttccg 2107381 acatctaaaa ggctttctgg ctctttcagg gcatcgattc cttttccgtg aatcacgaca 2107441 tcgctgctgc tttgctcaat gtgaacaccc atttttctaa agcaatcgat cgtgctcaga 2107501 caatctgctc ccggcagaaa gtttttaact gttgttgtgc ctgccgctag cgcgccaaac 2107561 ataacagagc ggtgagaaat ggatttatca ccgggaatat gtatttctcc atgtaaggtc 2107621 tgcaccttat ctcgtttcat tttttccacc tcaatcagca taaaaagttt catattccgc 2107681 ccgggcttca atgcattgtt ctgccctttt gcggtcgtca tcagactgaa aactgatcct 2107741 taaaatcccg ttaatatcct ctcgtgtttc gataatgcgg atattcgtga tactgatgcg 2107801 ctccgcagct aagatcgctg ttatctcgga tattacaccc ggatgatcgg gtacatccac 2107861 atataaatca taaaatgcag gtatcgctcc cttctgccga agcggcagcc cgtcgcgata 2107921 atccttggct gttttaaaat aacgaaatag attttccgca tcttcttgtt ctacatatgt 2107981 acggatcttg tcaatttcac gaatccactc atcaaaacgg tctaagattt tatctttatt 2108041 atgtaataaa atatcccgcc acattgccgg gctgcttgat gcaatccttg taatatctct 2108101 gaacccgccg gcagcaaaac gcttaacaag cggatacagg ttttccgaat gatgggtttg 2108161 gtgaacaagg ctagctgcta caatatgcgg aaaatgactg attacgcttg taacgccatc 2108221 atgctcctct ggcgacattt ccacaaaatg ggcattcgtc cccttcagca ggttttttaa 2108281 ctgttccaca gcttgtttgt ccgttttctg gcctggcgtt aaaatataaa atgcattttc 2108341 aaacaggaac tccttcgcag cggccactcc tgatttatgt gaacccgcca tcggatgccc 2108401 tccgacaaat tgatagcggc taggcagcac ttgatcagcg taatcaacca ctttttgctt 2108461 tgtgcttcct acatccgtaa tcaaaagctc atgttcaatt cctgaatgag ccagctcttc 2108521 aagcataacc agtgtttgtt caacaggtgt cgcaatgatt actgtagctg cctctttcac 2108581 accgctaata aacgaatcag cacgatcgtc tatcacgcct aattttaatg ccgctaccgc 2108641 ctgttcatca gagatgtcga ttccgataat ccgtttgccg ggatgatttt ttttgatggc 2108701 tagggcaatc gaaccgccta tcaatccgag accggcgagc aatattgtat ctttcatttg 2108761 attcatacgt catcacctgg tttatagact aaagaggtga tatttgatca cctcttataa 2108821 aatttcagct aaaatggcaa gtatttcttc attttgctct tttgttccga tcgtaatccg 2108881 gagtgatgtc gggaaaccta atgcgtttcc tgaccggacg atatagcctt tttccagcag 2108941 agcctgaaac agttcatcag caggacgttt aaagtcaatt aacacaaaat ttgtctgtga 2109001 agggtagcac tttaaaccat gagttttcgc aaaatcataa tactgctgaa ggcctgcatt 2109061 attttgctcg acacaggaag caataaacgc ttgatcatca agtgctgcaa tcgccgcagc 2109121 ctggcccaga cggctggtat taaacggctc tctcgccggc tcaatctggc gaatcaggtt 2109181 ctcgtcagca attccgtatc cgactctgag cgctgccaga ccgtatgcct ttgaaaatgt 2109241 gcgcaaaatc atcaaattgg aatacttgct taagagcggc acggtttccg ggtaatcctc 2109301 tgctgttaca tattcataat atgcttcgtc aagaacgaca aggacacgag aaggaacgcg 2109361 ctccagaaat gcgagtaatt ctccttcaga tgtataagtg ccagtcggat tattcgggct 2109421 gcatatccaa acgacttgtg tctgttcgtc gatggcttct aacatggcgt ctaaatcatg 2109481 tgagccgtcg ggacgaagtg caatttcacg tacttcagca ccttcaataa ccgcattatg 2109541 tttatattgc ggaaaagtgg gggcagcagt aaccgtgttt gttttatcgt ttaaaaatgc 2109601 ccggcagatg atctgtatga tttcatcaga accgttgccg aaaataagtg atgtttcgct 2109661 gacattgagg tgcttactga gccttgtccg caaagcggcg ctatacccgt ccgggtaaag 2109721 ggctagctgt tgaatctcat gatgaagcgc ctcttttgca gcctctgaac agccgtaagg 2109781 attctcgttt gaagcaagct tcacaacttt atccaagcca tattctgatt tcactgcttc 2109841 aatcggcttt ccaggctgat aaggcttcag ctgttttaaa tgttctttga tacgcaaatc 2109901 agtcacctca ttttaaactg tacaagccgc taaacgccat tgcataatcc tcaaactcct 2109961 gcagcgcctg atttctcgtt tcagcgctga tgagccggtc ctttaattct tctatttttc 2110021 tgacgagcgc acttcccact acgacaccgt cactaatttc attcatcttt atgacctgtt 2110081 cacggtttga tataccgaac cctacagcaa ccggaacagt gctgagattc ttcacagtac 2110141 gaatgaacgg gtacacggat gaattgaact cattgcggac accggtcaca cccagagaag 2110201 atacacagta gacgaacccc tcggcttgtt caataatggt tttcaaacgg ctttcgcttg 2110261 tcggcgcaac taaagaaata tacgtcacct catggctttt acattcctct tgaaggctgt 2110321 tgctttcttc taatggcaga tccggaacaa gcagaccgtc aatatgattt tcccgcagta 2110381 aagcgaaaaa gtattctttg ttcaattgta acacaggatt ataatacgta aagaggataa 2110441 tcggaatatt cactccgttt tttttcattt ctccgcctaa ttcgattgcc tttacgatat 2110501 tcattccttg atcaagcgcc cgctttgaag cccgctggat caccggaccg tctgcaagcg 2110561 ggtcagagta tgcaacacca agctccaatg ctgtggcgcc tgctttttgg agtgacttcg 2110621 ccagttcaat cgaaacctca ggaactggat cgcccgccgt aataaacggg ataaacaatt 2110681 tttctgatgg ttgaagatcc aatttaaaca tgggctttca cctcttcttc caatacattc 2110741 attaatgtgt tgacatcctt gtctccccgg cctgataaac agacgagaat gagttgaccg 2110801 cgatccattc ctttggcgag tttgaatgct ttcgctaacg catgggcaga ttcgattgcc 2110861 ggcaaaatcc cctctttttc tgacaaaagc tttaatgcat ccaccgcttc ttcatcggtt 2110921 atactgtcat aagtgacacg gccgctttta tgcaaatatg catgctccgg accgattcca 2110981 ggatagtcga gaccggctga aatagagtag ggctcaataa tttgcccgaa ctcatcctga 2111041 atgagataag tcaatgaacc gtgaataacc cctacggttc ctttcgaaat agtggcggca 2111101 tgaagaggtg tatcaattcc ttttcctgct gcttcagcgc cgatcagttc aacatcttca 2111161 tttaaaaatg cctgaaacat acccatcgca ttgcttcctc cgcctacaca tgccactact 2111221 ttatcaggca tagtgccttc aatacgtttc aactgatcct tcgcttcctc tccgatcatt 2111281 ttttgaaatt cacggaccac ttgcggataa ggatgcgggc cgacaactga tccaatcata 2111341 taaaagtgat cctcacaatg ctgaacccag taccggatcg cctcatttgt ggcatccttc 2111401 aatgttccgt ttccgcttgt tacaggcact acctccgctc caagaagctt catgcggaaa 2111461 acgttcagag actggcgggc aacatcctct tcacccataa acacagtaca ggaaaagccg 2111521 aatttggctg caactgttgc agcggcaaca ccatgctggc cggcaccggt ttcagcaatg 2111581 attttcgttt tgcccatttt tttagcaagc agcgcttgac ctagcgcatt attgatttta 2111641 tgagaacctg tatggtttaa atcttctcgt ttcaaataga ttttcgcgcc gcctaagtat 2111701 tcagtgactc gatcagcgta tgttaatgca gtcgggcgtc cggaatagtc ctttaacagc 2111761 ttataatact cttcacgaaa agcgggatca tccttgattt gtttaaatgc tgtttgtatt 2111821 tcatctaacg gctgcatgag tgtttccgga acaaactttc cgccaaaatc accgtatctg 2111881 cctatttcat tcggatatgg atacatatcg gttcatcctt tcttctaaaa gcctcatcag 2111941 attctgatct ttttgtccgt ttttttcaat tccgctggca aggtcaattc cttctggctg 2112001 ccatttcaat aggcgtgtga tgctatccgg attcacgccg ccagcgataa agcagcgttt 2112061 accaatagcc gcctgctgat attccggcac acattcccaa gaaaatgcaa caccagttcc 2112121 gcctctagac ccttttacag atgaatcaat cacaaagccg tcaacattat ctttaaagcg 2112181 ggctatttct tgagttgtgt tatcttgatg gtgaagcgcc ttccatattt cacagcctgt 2112241 cagcttgcga agagcagcag catccgccgg tttttcatca ccgtgaagct gaatgacgtc 2112301 gagcttcaag ctcttggcaa tacgtgacat cgtctctatt gattcattaa caaaaacacc 2112361 tgcaacctgt ttttcgacac gaacttggtt cagccatttt ttcacatctt ccggagatac 2112421 ttttcgtttg ctttcagcaa aaataaatcc taggtaatca gcctgtgatt ccgccgcaag 2112481 ctgcaaatcc tttagtgacc gaataccgca atattttaat gccggtttct tcacaacctc 2112541 actccctaaa caaagcatgg attgctttac gctgagaagt ttgtctcatc aatgattcac 2112601 cgataagtac agctcgcgcc ccatgttcat tgacaaatgt taaatgttct aaagaaccga 2112661 ttccgctttc gctgacaagc aaggattctt tcggaacgag agatgcgatt tgttctgtct 2112721 gctttacaga tgtttcaaac gtttttaggt ttcgattatt tacgccgaga atgtcgggtg 2112781 tgaacacttt caatatttgt tctagcgttg atgcatcatg aacctccact aacacgtcca 2112841 tccccttttc acctgcttca agatataatt catgaaggtg taagggatca agcacctcgc 2112901 cgattaacaa tatggcatcc gctccgattc ttcttgattc ctctacttga agagaatcaa 2112961 taaaatcttt tctaagtaca ggaatcgaaa cagcacgctt tacgtctgat aaatagctgt 2113021 tttccccttg aaaaaacggg gtgtctgtta aaacggaaat cgcatctgcc ttcgcagcct 2113081 catagtcttt tgcaatctgc acaggtacaa aatcctcttt aataagccct tttgacggcg 2113141 atgctttctt cacttcggca atcaacccga taaaccgatt cgggcttgcc agcgcctcct 2113201 taaatgaacg tttctcgaaa ggctgctcta ccggcagaac cagtgttttc acttcttctt 2113261 tcttttgttt gatgattttt tcaagcatag atctcttcct ctttctgctt tagtcgttca 2113321 agctgcgcgg cagcgcctcc gcttgtaatc gtctctaacg ccagctccgt tccttccttc 2113381 agtgaggcgg taattcccgc cgtgtaaatc gcagcacccg cattaaaagc cgtaatagat 2113441 aaagcggaac tgctgctttt attttcaaaa atattctgaa tgagataagc gctctctttc 2113501 ggagactgca cctgtaaatc ttcaagtctg ccatttgtga aaccgaaatc ttcgggtgaa 2113561 acggtatact cccggcgctc tccgtccttt aattcaatca cgtcggtcgg tgctgtaatt 2113621 gaaagctcat ctaaaccgtc acggcttgat acaaacataa cgtgcttcgg ctgaaacgtc 2113681 tccagtgcgc ttgccatcag tccagctttt tcaacagaat agaccccaat cacctgacgc 2113741 ttcgcctgta aaggattgct gagcggccca agcagattaa ataccgttct gaaacctagc 2113801 tcttttctag tacctgctac atgtttcata gacgaatggt aaagcggcgc aaaaagaaat 2113861 cccatgttgt ttgtttcaat gctgcttttg accttttcgg gagtggtttg aatagaaacc 2113921 tctagctcct ctaaaacatc agcgcttccg cttttagaag agacagagcg attgccatgc 2113981 ttagcgattt tcgcaccagc tgccgaggca acaattgccg aggccgttga gatattaaaa 2114041 gtggaaatac cgtctccccc tgttccgcat gtatcaacaa tatcaggaag tccatcgact 2114101 gtaagagcgt gtgcccgcat tgccttcaca aaacccgcaa gctcttctgg cgtctccccc 2114161 cgatgagcaa gaattgacaa tatccccccc atttcagaag gagtcatttc cgctgccatc 2114221 atcatattca tcagcgtttc agcctcaccg gcagtaaggg tttttccgtc aacgcacaat 2114281 tgtagaaatc tgttcatcag ctttatcctc cttgctatga aacatgtctt ctgcaatatg 2114341 aatcgttttc agcagcgcac cggctttatt acagctttct tcgtattcgg cttccggaac 2114401 agaatcagca acaatgccag cacctgcctg tatcgatgca acaccgttct ttacactcat 2114461 cgtgcgaatc gtaatacaag agtcgatatt cccgtcaaac ccaatgtagg caatacaccc 2114521 tccgtatgtc tctctcggtg ttggctcgag ttcttgcaaa agctgcatgg cacggatttt 2114581 gggtgcgcct gttaaagtcc ccgccgggaa agcagacatc agtgcatcga caggatgaac 2114641 cccttttttc aatcggcctg taaccaccga gataatgtgc atgacatgtg aaaaggaaac 2114701 aatttttgtg aactccggca cagaaacaga accatactct gctactctgc cgatatcgtt 2114761 tcgggcaaga tcaacgagca tgtaatgctc cgctttttct ttttcatcct tcatgagctc 2114821 aaccttcagt ctctcatctt cagctttgtc tgcaccgcgt tttctcgtac cggcaatcgg 2114881 atggatttct aagtgcccgt cttgaacgtg tattaaccgt tccggagagc tgccgactat 2114941 ttctctgtct agcagtttca tataatacat atacggcgaa ggattgacga tcctaagcac 2115001 tcggtataac tcaaaagcat ctgcttttat cggcacctca aatttttgtg ataaaacacc 2115061 ctggaagata tcgcctgctt ttatatagct tttgattttt tctacatcag ccataaaagc 2115121 cgatttttca taattagaag atactgtctc aaagctgggt gtcttgtatg aatcagcaga 2115181 aagaaacagc tcttttatgt ttttttggtc catcattttt tcaatgagat tttgaagctc 2115241 cagatgattt tgatggaata catccatttt ttcgtttttt gtttcctctc cagtgagcct 2115301 tgcatattgg ataaagtgga cgtttttggt ttcatgatca tacgcaatta atgtccggca 2115361 aacaaacagc atacactttt ccatgtctgt ttctttggta tgcgaaggaa cagaaggctc 2115421 aatcagcggg atcatatcat agcttaagta cccgacagct ccgccgacaa aaggaatgcc 2115481 aagctcaggt gttttgattt tgtatgtggt attcatccag ttcagcactt cttttagttc 2115541 atttcctgtg taaagagatt tgctgtcctg atcagcggcc gaaaaacggc cctgctcttc 2115601 tttaattgtg agaaatggat tcaggccgat aaacgaatat ctggaccaag tggatgtatc 2115661 gtccttgctt tcaagaagat acgtaatctc cctgtcaagc ttctctatca tttgaatggg 2115721 tgtcagtgta tcgactgtga aggtctccac aatcggtatc gtgtggtggg acaagctgtc 2115781 ctctaaaaat gcggaaatgt ttgattggaa attcattgct ctcactcctt atggcaagga 2115841 gaatgagaag atggcatgag aggataaaat actatataac aaataaaccc aaaagaaaga 2115901 cttcttttgg gtagaataaa cataatgtct cagctcaact aaactcattc tctgctaccc 2115961 tattctctaa ctcaactcat tctaattgct ttatacacac tcttgtgtat ttctaagctg 2116021 ttcttatcgt attacaattc agtatttttt gtcaatgata aatcgggcct caatacgaca 2116081 actttttcta aatatacatg tctgatctga tcctgaggga catctgtctg gaccgtcatc 2116141 atgactctta tgcacttttt cagaccgcct gttacgtcca tttcctgcat acatgttacc 2116201 ggtacatact gccatcctga aagctcgcga acagcttttg ccgggaaaac agcgtgcaaa 2116261 tcaggtgtag ccgacagaag catttgaaca acatcttccg gttttgtatg attttcttct 2116321 atgattttct ctaacagctg tttagttttt tgtaaaattt cttcttcagt atcccgttca 2116381 actgtagttg ctccgcgaat tccgcgaatc atcatgatgt ctcctccaat cgccatttgt 2116441 tcagccagct ctcaagttca tttctggaaa atgtatgatc agcaactttc cctaattcgt 2116501 tgagcacaat aaactgaatc ttcccgccac gggttttctt atcattcatc atacggttca 2116561 agagaaccga agtttccgtc tcttttctga tttgacttgg ataacccagg ctttttagcc 2116621 agctgaccaa acgttttctg tccatttcac agcctacagt cttttcgctt atatataaag 2116681 caaactgcat tccgagggct acggcatcac cgtgagtgat ctgcccatat ccatattccg 2116741 cctcaacggc atggccgagc gtatgcccaa agtttaagta agctcttatc ccctcttctt 2116801 tttcatcctg ctgaacgaca gacgctttaa ttgaaatgcc tttaaaaatc atgtcattca 2116861 gctgatcatt agtgatatca cgcagtgagt ggatattcag cagctcctcc agaaacgctc 2116921 tgtcatagat aaaagcgtgt ttaatcactt ctgccattcc ggacctaagc tctttttcag 2116981 gcagagaacg caggaaatct gtatcataga gcacggcttt cggctgataa aacgcaccga 2117041 ttagattttt tccaagcgga tggttcacgg ctacttttcc tccgactgcg ctgtcatgcg 2117101 ccaagagcgt cgtaggcatt tggatgaaat caatgccgcg cataaaagtg gcagccacaa 2117161 aaccggcaag atcccctaca acaccgccac cgaatgcgat gatgcatgag gagcgatcca 2117221 tatgaaaacg aatcgcttca ctctgcaatt ttgtgtacat gtccatggat tttgcctgct 2117281 ctccactcgg taccgtcact tttttcacag gccatttttc ttgcagcaaa tggagcattt 2117341 catcaccata caggcggtcc acttcttcat ccgtgacaaa cataatcctt gttaaaggcc 2117401 tgtttaaaga ggttaatagt tcgcaagcct tttttctgat accttgtccg ataaaaacag 2117461 gatatgacga ggaagcagtt tgaacatgca gtgtcttcat taaaattccc tcgacagttt 2117521 tctcatattc tccacatttt ctctaatgcg gtcaatttga tctaatccga attgttcaac 2117581 gactgcgttc gcaatttccc aagcgacagc cgcttcagcg actacacttg ccgcaggaac 2117641 agcacagctg tctgaacgtt caatgctggc agaaaacggt tctttcgttt caatatcgac 2117701 acttttcagc ggtttataca aagtcggaat cggcttcatg actccgcgga caacaatcgg 2117761 catccctgtc gtcatgccgc cttccagtcc gccaagtctg ttagtagcac gggtgtatcc 2117821 tttttcctcg tcccaaatga tctcgtcatg gacttcgctt ccatttcgcc ctgctgcctc 2117881 aaatccgatg ccgaattcca cacctttaaa tgcgttaatt gacagaacag cggcagcaag 2117941 cttgctatcc agcttgcggt cataatggac atagctgccc acgcctaccg gcattccctc 2118001 gacaatgact tctactattc cgccgatgga atctccgttt gcctttgctt catcaatggc 2118061 agccatcatt tttttgcctg cctcttcatc gtagcatctg acaggagact cttccgttac 2118121 acgctgcaag tcttcaattg acgtatactc tgttttttca gctttaacag cgccaatttg 2118181 caacacgtgg cccgccacct taatgccaag ctcagaaaga atctttttag ctacagcccc 2118241 tgccgccact ctgacagttg tttcccttgc tgaagaacgc tcaagcacat ttctcatatc 2118301 acgatgatta tatttaattg caccgtttaa gtcagcgtgc ccaggtctcg gtctggaaat 2118361 ctggcgcttc atttcctttt cttcatcttc tgtaatcgga gcggcgccca tgatttttgt 2118421 ccaatgcttc caatcgttat tttcaactac gagagcaatt ggcgaaccga gtgtacgtgc 2118481 atggcgcacc ccgctcataa ttttggcctg gtctttttcg atctgcatgc ggcggccgcg 2118541 gccgtgtcct ttttggcgtc tggcaagctc aaaattgata tcttcctccg ttatgtaaag 2118601 cccggcaggt acaccctcaa taatggttgt cagttggggg ccgtgtgatt ctccggctgt 2118661 taaatatctc atgacttctt ctcccttcat cgcattaacg cttttaagta agactactat 2118721 aacatatttt tcagcaaaaa gtcagtctat cttttttgat aaaagaatgt atcggctggg 2118781 actaggccaa atttctcggg attgaagatt tgctcggtgc tgccgacaaa aagaactcca 2118841 ttcttcttca agctatgtgc catttttaaa tacagctctt ccttcgcgct ttctgtaaaa 2118901 taaataaata cattgcggca cacgattaag tcaaagtctt gttcataacg atccgccagc 2118961 aaattgtgct ttttgaatgt aatattcttt ttgatttccg ttttcacttc ataacttcta 2119021 tttgcgtttt gcgtaaaata acgatctttc acagatagcg gcacttcctg taaagaccgc 2119081 tcctgataaa cgcctttttt cgctttttcc aatgcttttt catcaatatc cgtcgctaaa 2119141 atctgatagc ccggaagacc tttttgctgg tccaaaagca tggcaagcgt gtatggctcc 2119201 tcccccgttg agcaggcggc actccaaatt tttaaaggcc tagaggtctt gattaacggc 2119261 agaattgcag tctcaagaac ttcccatctt ttataattac gataaaattc tgaaacattg 2119321 atcgtcattc tgtccaatgt ttcatttaag agagcttgat ccttttccaa tgccgcagca 2119381 aagtccttaa agctttggaa cccctttttc tcataaagtg acgttagcct tctcttcatt 2119441 tgtgcttctt tatatagtgt taaatcgact ccggttaatt gtttccattt cgttgtaaat 2119501 acgctgtatg tatccatctc tactctccca gtctcgctgt ctttttgtcc tagtatagct 2119561 tgttttatca ggaaattgta ttgtttcaat aaaaaaatca gcttttcagc tgattttaga 2119621 tcgttgggaa aggcagaggt ctgatgcaca ctgccattca accctttatt cactttaatg 2119681 taaaccttta caaaacagaa caaaaaccgg cggcgttata tgttgccggc tctgttgctt 2119741 attttcacaa tgattaatag atccagcctg ccataagctg ctgatatgat actaattctt 2119801 cattcttaaa gaaaatgtta atctcgcgtt ctgcactttc gagagaatca gagccgtgga 2119861 tgatgttttt tccgacaaac atgccataat ccccacgaat cgtaccaggt aaagcttctt 2119921 tagggtttgt tttcccgatc agctgtctcg tcacttcaat gacattttcg ccttcccaca 2119981 ccattgcgaa tacaggtcct gaagtaataa actcaacgag ctctccgaag aaaggcttac 2120041 cttgatgttc ggcgtagtgt ttctcagcca tttgttcagt cactctcatt aacttggcgc 2120101 cagctaattg taagccctta cgttcgaatc tagataaaat gtccccaatg agctgacgtt 2120161 ggacaccgtc tggtttcacc atgataaaag tcttttccat catattctcc accccatcat 2120221 tatgtatgta taggctttca cactgcacac cgaaatcgta acatctttct gataattaat 2120281 caatccgggg cggagaaatt tcttaatatc tacaaaaatt aaaattttct tttaccgata 2120341 tattttgcga tggctgcaag agacgagcgt gcgcgccctc gaggaagcgt gtttaatttc 2120401 tgaaaagctt tctgcagata catttcgctt actgccatag atgcttcaat tgcatctgtt 2120461 tttttgattt cttcaatgat tggttcaagc tgttcctgcg ttgtctcact gttaatcaat 2120521 ttaagctggt tttttaatgc aggatttttc agggcataca gcactggcaa tgtgacgttt 2120581 ccttgaagca aatctcctcc tacgggttta cccagctctt cctcagttga agtaaaatca 2120641 agaatatcat caataatctg ataagacatg ccgacgtaat acccaaacca gtacaatgcc 2120701 ttatgaatct tctcatcagc tccagacgca atggcaccaa gctggcagct gaccgcgatc 2120761 aagagagctg tttttctttt gatacggcgg agatacgttc tgagattttg ttccatgttg 2120821 tatttgtctt tgatctgctc aatttcccct agacaaactt caacgatcgt ctgtgacaaa 2120881 atcctatggg ctttcggttc gttaattctc gtcatcattt caagagatcc cgcaagcata 2120941 taatcgcctg tgtacatcgc aatacgattg tcccactttg ctttgattgt cggttttcct 2121001 cggcgaagct ctgcatcatc aatgacatca tcatgaacca aagatgccat gtgaatcatt 2121061 tccagagtga cggcgacata tttaatctta ttaatatcat aatcgccaaa catgccagaa 2121121 agcagcacga aaacaggccg aatacgtttc cctccggcct gcagcaggtg aagacctgcc 2121181 tcgcttaaaa gcgggtaatc ggaacgtacg gtttgttcaa gttctctttc gattacatca 2121241 atatcgtcat ttaaaaaaga gtaggccatt ttaaatttca tatcattcac ccaaacatct 2121301 gtgttttcat ttccatccga tatgcgtggc agcgactccg ccagtaaacg aatgatattt 2121361 aacatttttc aggcccgcct cttcaaacag gcctgccagt tccttcattc cagggaaatc 2121421 tctggctgat tcttgaagcc aagaatattc tttatagctc ttcgcaaaca gtttcccgaa 2121481 aaacggcata atatacttaa agtacataaa gtaagcctgt ctgaatccga acatttccgg 2121541 ctgggacgtt tccagacata ccacctgccc gcccggcttc actacacgtc tcatctcttt 2121601 cagtacagtc aagtaatcag ggacattgcg gagtccgaag ccaatggtga cataatcaaa 2121661 tgtatcatca tcaaaaggaa gctccatcgc atttccgtgc agcagttcaa tttggctgaa 2121721 tccgccgtct tttactttct gctcgccgac actcagcata ttttcactga aatccaagcc 2121781 cttgatctcg ccgcttttgc ctgccgcttt tgcaagagcg atcgtccagt cagccgttcc 2121841 gcagcagaca tcaagtgctt ttgcgccttc ctttacattc atgatgcgca tcgttttgtc 2121901 gcgccatttt ttatgctgct gaaaactgat gacagagttc atttggtcat aatttttata 2121961 tattttttca aatactccgt gtacgcgctg ttcttttgag tcctgcataa tggtttaccc 2122021 ttcttccact ttctgatgat aggtttgatc ttggctgatt gtcttcagac ggtttattaa 2122081 aatgttctga ataggtgaat ttagaggcag aagtgactca atgctgtttt tcgctttttt 2122141 aaaacaatct tctaatatct cttcttttgt ttttcccagc tgtataaaac tgccgatcac 2122201 atccagaaat gcatcatttc cgttcataag ccgcttaaat acaaaaaaat cactcgacag 2122261 ctttttccag cgcgggaggt tgaagtgttc cgccacacga tggaataaag ctgattcaac 2122321 gatgccgaca ctttcgaaaa aatcgttttc gtccttgaaa gaacggtcat acagacgaat 2122381 tttatgttcg ttgatttctt taatggctgt agcaagcgtc cgaatcatgt agatatcctt 2122441 catttcagat agtaaagagt agtacagccc gctgaaataa tcgcccgcga gaacagtcaa 2122501 ttggcggttt ttgttttcgt ctcgttttat gactctagct gtcgtcactt catcatgggt 2122561 atcaagggcg ctttgtacaa gcatcgctgt tacaatataa ttttctctgt cgttgttttt 2122621 tatgtcggct tcttcaaata aagcatgaaa aagaagaagc ttatcctcat caattttcgg 2122681 cgcagaaata tgcttcgcta aataaggatg agacagcttt tgttttaatt tcgtgttcag 2122741 attggctaaa gttccgtaga tgtcttgcaa aaatatcacc cttgtcccca aattcacatt 2122801 tatttcttaa tctatgtatg agttttatct tttcattcgc ttacgcaggt atcattatag 2122861 cataaaaaaa agaaattggc tgtatcctcc cgctgtttgc gagcatttgc ttttaacagc 2122921 ggggacagcc agcttatttt ttttcgcttt tcatttctcc gtacgcggtt tgaatcagtg 2122981 cctctcctct gactttaatg gcagaagtat gctctgtaaa ctgagcgatg atcacttctc 2123041 ccttgtcgag tttttcggaa tggtgaaact ttgtgtctgt tcctcttgtc aggccgatca 2123101 cattcactcc gtcctcaacg gctttaatga cgacaaaatc acttgaatgc ttttggttca 2123161 tttatagcac cctctatctt tattagtcct ggcgtttaat atgttccaat acttctgcac 2123221 gggcagcggc atcatcttta aaaacgcctc tgactgctga agtcacagtt ttcgcacccg 2123281 gttttcttac accgcgcatc gtcatgcaca tgtgttccgc ttcaaccact accattacgc 2123341 catgcggatc aagcgtttct acgatgcttt ctgcaattgt agaagtgatg cgttcctgaa 2123401 gctgcgggcg ctttgcaacg gcttcaacgg cacgtgccag tttgctgagt cctgtgacct 2123461 ttccgcctcg cgggatatat gcaacatgtg cttttccata aaagggaaca aggtgatgct 2123521 cacacataga atgaaacgct atatctttta caagaacaag ctcctcatgg ttttcaccga 2123581 agatagtctg gaaatgttct tttggatctt cattcaagcc ggagaatact tcggcataca 2123641 tctttgcgac tcttttcgga gtatcaagaa gcccttctct attcgggtct tctccgatcg 2123701 cttctaaaat ttgacgaaca gcttgttcga tttgctcttt attaacttct ttcatgttct 2123761 atgtcctcca ccaatgaata catttaattt cgattctagc acatatgccc cgctaaaagc 2123821 aaagtgaatg ccctgtcagg aagcccatgc tcttgaaata tgaaaagccc cttagaaagg 2123881 ggcttttctg tgaagaaata aagtgtatgt aagctagatg catacacgat ctatattcac 2123941 aattattttc cggcaactgc gtctttaagc gctttacctg gtttgaaagc aggtactttg 2124001 cttgctggaa tttcgatttc ttcacctgtt tgaggattgc gtcctttacg tgcagaacgt 2124061 tcacgcacct cgaagttacc aaaaccgatc agttggattt tatcaccgtt tttaagtgca 2124121 tctaagatcg tatcaaaaac agagtcaact gcttttgtag cgtctttttt agacaattcg 2124181 cttgcttctg caaccgcatt gataagttct gttttgttca tgcctttcac ctcctcccaa 2124241 aaggatacat tcagttcgtt tattatcatt tcttcacagt tcagtctgat tctaaacctg 2124301 tctcagaaaa aaatgagagc aagtaagaga aagacaatta aacggctttt taagaaaaac 2124361 tgcactctga ggaatgtttg tccaacaaag tgaagaattt ctgtatgtag agtaacacat 2124421 ataaaaagcc atatcaagca ttttaaagcg tcaatccctt gctcgtcaag gatttaaggt 2124481 gatttaccga acgaatattc ctttttttcc ttttttcatc ctattccttg atccttttcc 2124541 attattaaga gcaaagaaaa aagacctccc attctataaa gaggtctacc ggtattacag 2124601 gatgatggcg attaagccgc cagagccttc gtttatgatt ctttctaatg tttcttttaa 2124661 tttataccgt gcgttttcag gcatcaatga cagctttgcc tgaatccctt ctctcacaat 2124721 tgagctcagc gaccttccga agatatcgga attccagatg gagagcggat catcctcaaa 2124781 gtcctgcatt aaatagcgta caagctcttc actttgtttt tccgttccga taatcggggc 2124841 gaattcgctt tcgacatcta ctttgatcat atggatcgac ggagcgacag ctttcagcct 2124901 cacaccgaat cgcgagccct gccttataat ttccggctca tcgagactca tatcagctaa 2124961 agcaggcgct gcaatgccgt atcccgtctg tttgaccatt tttaaggcat cagacacttg 2125021 atcatattct gttttcgcat gggcgaagtc ttgcatgagc tcaagcagat ggtctcttcc 2125081 tctgatttcg acgcccacaa cttcttttag gatttgatca tatagatgat caggcgcgta 2125141 caaatcaatt tctgccaccc cttggcccag ctcaattccg gctaatccgg cactttcaat 2125201 gaattcaaac tcgctgaatt ggccgacaac cctgtctacg tcccggagcc gtttaatatc 2125261 cttaaccgtt tccttcacgg actcctgata gctttcacgc aaccaatggt tttctttcag 2125321 caccattacc cagcttggga gattgacatt cacttctagc accggaaact cgtagagggc 2125381 ctctctgagc acactcagca catctgattc ccgcatgctc tctacactca ttgccaatac 2125441 cgggatatca tatttttcgc ttaaatcctg gcgcatggct tccgtttccg ggtgatacgg 2125501 cctgactgag ttgatgacca taataaaagg tttgccaacc tctttcagct cttcaatgac 2125561 tctttcttca gcctctatat agtcacttct ggcgatatct ccaatggtgc cgtctgtcgt 2125621 aatgacaact ccgatggtcg agtgttcttg aatgactttt cgtgtgccga tttcagcagc 2125681 ctcatgaaat gggatcggtt cttcgtacca aggcgtattg atcatccgcg gcccgttttc 2125741 atcttcatat cctttagcgc cgggcactgt gtaacctaca caatctacta atcttatatt 2125801 cacatcgagt ccgtctgaca catgaacaga catcgcctga ttcggaacaa atttaggctc 2125861 tgtagtcata atggttttgc cggctgcgct ctgcggcagt tcatcctgcg ctcgggcccg 2125921 gtctgcttcg ttactgatat tcgggagcac cacaagctcc ataaattttt taatgaacgt 2125981 ggattttcct gtacggacag cacctacgac tcctaagtat atatcgcctc ctgttcgttc 2126041 agcgatatcc ttgaaaatat cgaccttttc caagtgatcc cctcccggac ttcctatcct 2126101 tttcaatttt attaagctct ttcaatcaaa cacaggacac tatatgtgta tgacgttgtc 2126161 ctatttgaat atgacatctt tagaaaattt ctcatcctca atctattaat ataaaaaaac 2126221 ctttctccct atttgtatgc aagggagaaa ggttcattcc tttttcatat cattttctaa 2126281 aaaaacaggt tcctgtttgt catttaccgt atattttaca gaaaacgcgg ggacaaaggg 2126341 ggtttcatgc caaatcatat cctggatttc agtcccgggt ttaaacgttt ttttgctttt 2126401 tttgaggcaa gaagccagct cagtccggta atcggcatat atttctccgt ctccgtcaat 2126461 cataagcggc aaggaattcc ctgagattgg gcttgtcact gtaagagagc tgccatcccc 2126521 aagcttcttc tcatcgagtg taaataaatc acgagatagc acatccttgt aaggcggata 2126581 ttgatgctcc tgacgataca tttggatgcg caatttcaca tcgcgaattt tttctgccat 2126641 ctttagatca attaatttaa cagtcggatc gttctctacg tcaacaagca cgtattgata 2126701 gtctcccccg ctttcaaatg ccgtacttgg aggttcagct atgtatcttg gcgctaaccg 2126761 gttaaagtct atcggatatt tttgatatag cggtgtcgac atatctttgg tttgaatagg 2126821 aagcagccct ccatttgcct tttgaaattc atcaacagca gattgaacct gctttagctg 2126881 gtcttgataa ggaatggcat gcacactgct tttccgttca tttggatata aacatccgga 2126941 taaaaacacg actgccgcaa aaatgattgc gcacttcagt ttacccatac agcacttcct 2127001 tttacagctt tattcattga cagggccgct aaaaaccacg acaaacacaa taattccaga 2127061 tatgagcata cacatgtatg cgaatgatga aatcgcaatc ttcaaaaaac ggttttggca 2127121 cttaaagcgg cttaaataga tggaagctac agccagaaac atcagaccca tggaccctag 2127181 agcaaaccac attttcatca atgccagatt caatgacgtg cgcctccccg atatgtaaga 2127241 tataagcgtt atattatatt ttaatataca gcgccggaaa agatcaacca gattttccat 2127301 ccattgatag aacaaaaaaa ctgaagcaaa gagggggacc ttcgcttcag tcaacttgac 2127361 tatattcacc tgcacgttta agaaacactc tcttggactt cgatgctata gtatgcgact 2127421 tggcatacag atgcatcctc tattgcctaa atcggcaaaa tgtttcagga gatcccaaga 2127481 cttgggtgtt cttctgtttt tcgggctttc gttcaattaa gatatgcgat tcaccatttg 2127541 attgacactt ttacttcact tgattttcaa acgtatttac caaatcctcc atctcgtggg 2127601 ttttccctct cgccattaaa gattcaacag cggtttccac tttttgtccg ttgaatagga 2127661 cctgatggag agcttctgta atcggcattt taacatcata tttcttcgaa agctgataag 2127721 ccgctttcgt cgtgcggacg ccttcgacta ccattcccat ctcttcaaga acatcttcaa 2127781 gcttgtaccc ttttccgagc aaattgcccg cacgccagtt tctggaatga acacttgtgc 2127841 acgtcacaat cagatcgcct actcctgtca atccagagaa cgtcaaggga tttccgccca 2127901 ttttcgttcc gagtctcgcg atttcggcaa gtccgcgtgt aatcaaagca gctttggcat 2127961 tgtcaccgta ccctaaacca tctgtaattc ctgcagcaag ggcaataata ttttttaaag 2128021 cccctccgat ttcaactccg ataatgtcag gatttgtgta cacccgaaaa ttgtgattaa 2128081 taaatagatc ctgcacctct tctgctgccc tcatgctctt tgaagatgca gtaacagttg 2128141 tggggtgccg cagccctact tcttccgcat gactcgggcc ggaaaggaca acgatatctt 2128201 ttctgacatc actcgggagc tcaatttcca taatttcaga aatgcgcaga agtgaatctg 2128261 gctcaatacc cttgctgaca tgaacaaaga ctgccttttt cgttataaaa gggacagcct 2128321 gtctcagcac ttcccgaatt gcttttgtcg ggaccgcaac gataatgaca tctgcgtctg 2128381 aaacagcctc tttcatatct gttgttcctt taatggatgt agacagctta acattcggca 2128441 aataatcttt gttttcatgc aactcattaa tttgatgaat taaatctgca cggtgagccc 2128501 acacacacac ttcatttcca ttatcagtta gaactaaagc cagtgctgtt ccccaactcc 2128561 ccgctccaag cattgtgact tttttcatgt ttgattcaca cctttttatt ttctagctct 2128621 tgcaaatatt ttgattggtg tcccctcaaa accgaacgcg tctctgattc ggttttctaa 2128681 aaaccgttcg tatgaaaaat gcatcagttc cggatcgttt acaaacacaa cgaagcttgg 2128741 cggctttacc gacacttgag tcgcatagta aattttcaaa cgagaaccgt tatgagtcgg 2128801 tgtcggattc attgccacag cgtccatgat gacatcattt aagacgtttg tttgaactcg 2128861 aagtgaatga ttttcactag ctttgataat cgcaggcatc agagtatgga tccgtttttt 2128921 cgttaaggca gacataaata ggattggcgc ataatccaga aattgaaaat gatcgcgaat 2128981 attttcttca aattctttca tcgtgctctc atctttgtca acagcatccc atttgtttac 2129041 gacgatgacg acggccttgc ccgcttcgtg tgcataaccg gcgatacgct tgtcctgttc 2129101 aataatgcct tcttcgccat ccagcacaac cgccacgact tctgagcggt caatcgcttt 2129161 tagcgcccgc agtacactat acttctcagt cgtttcatag actttccctt tttttcgcat 2129221 acctgcagta tcgacaatga caaactcctg ctggttgtaa gtaaatgacg tatcaacagc 2129281 atctcttgtc gttccagcca cgttgctgac aataacgcgt tcttcgccga gcatcgcatt 2129341 cacaagtgaa gactttccga catttggacg tccgatcaga cagaattgaa taacttcttc 2129401 attgtatttc gtttcaggaa tgtttttaaa atgctctgca acggcatcca gtaaatcacc 2129461 cagtccgagt ccgtgtgttc ccgaaattgg atacggctcg ccaaagccta gcgaataaaa 2129521 atcataaata ttcgctctca tttctgtgtt atccagttta ttaaccgcta aaacaacagg 2129581 cttttttgtg cggtacaaaa ttttcgccac ttcttcatca gcagctgtca cgccttcacg 2129641 gccgttcacc ataaaaataa tcacgtccgc ttcatccatg gcgatttcag cttgctggcg 2129701 aatctgcgct aaaaacggct catcaccgat atcaataccg cccgtatcaa tcaaattaaa 2129761 atcataattc agccattcag ccgagctgta tatccgatcc cttgtcacgc caggggtatc 2129821 ttctactatt gaaattcttt ctcccgcaat ccggttaaag attgtggatt ttcctacatt 2129881 tggtctcccg acaatggcta cgacaggttt acccatagta cccttccttt caatccagcc 2129941 gctttcattt ttacataaat tttcaaccgg ttattaaaat catttcattc acttttatga 2130001 aaagaaaccc ttcagaggaa gggcttaact catttattat atcagttttt actgggatca 2130061 caactattct taaaaatgtt tcacgatcaa atacacgtca tctccgattc tgtgagctat 2130121 tccatcaagg atcgcctcaa gatttttagc gaaaagctcc atctcctttt ggtcattgca 2130181 aaaaaagaca ggtgctcccc ctgcaacccg atttcgattt gtcgtgatta cagacaaaat 2130241 cactttcgta agagattcac tcatcctatc accttatcct gattcttgat aaattcagtc 2130301 ggcattctaa tcgcattttc cagggttgga acattgctaa taatttgaac agccgtttcg 2130361 ggatggtgaa tttgcgggag aacaaatact gccactctcc catcatttaa atcccgtttt 2130421 gcaattggtg tcaaagatgg ctctcctgaa tcccgataaa ccccgagcac attggaaaca 2130481 tcaaataaaa tggcctgacg ctgccctaaa tttgctatcg tcgctgctga attaaagttt 2130541 ttcggcgtca aaataaagcc catgccatgc tttaaaatca gttcctgttt ctctggaagc 2130601 ccgatattca tcatataaat attatcaaca aacagtcccg gaccgtcaaa gcgcggcttt 2130661 atgtactcga tatctacaat atccttcaac acactgcccg acataaactt catggccagt 2130721 aaaaaacaaa cgacagccgc tatgactgca gcccagatgg ataaaaacac atacgcagag 2130781 gttgtcaaaa gcgctgtaaa gatcacaata taatttctgc tttcaaacgc aatggcaatc 2130841 ccctcaatat atgtgcttcc ccttgagaca agttcatacg aatccatttg cgtcaatgtg 2130901 ttccgctcca tgtttcggac atctctaaat tgcgtcgctg ccaatgttaa aaatgtgatg 2130961 gccgtaaatt cctcctgcaa aagcgccggc ataataattg cacctaaacc agccgctatc 2131021 aaccccagtg cgatgtgaat cactttccca tgaacatagg tcggatactg gcggtaatcc 2131081 gttttcagca tataaagcct tgtcgcaatt ccggcaatga ccccagcaat aatcggatag 2131141 atgtaatcac tcatgacatt ttggtagctc ctttgtttga tcttttgctt ttctgaccaa 2131201 tctggcttgc gaggtgttcg tatttagata tgccaaacag caatatcatc cccgcagaac 2131261 acgcattcag ccattgaaag ccgccgacag ccatagcccc ggccaacttc tggatcacaa 2131321 atgaatacac cagttcgcct tggcacatcc ctaggacaaa taagacaagc tgcttctcaa 2131381 aattcctttc aacagaagct gttaaaagca ctattaatat aacagcagcc cactcaggtt 2131441 ttatgatgaa ccaaaccggg tcatataatg caaaaagata aacaaacgca tacgcggcaa 2131501 caagcgtcag atagaccatg atgtaacgaa aacgatacat tcccaaatac ccggcataga 2131561 cacatccgca aacgaaaaac atcaaatatg cagcattcag ggaaaaatat aaagcgatgt 2131621 catgtatgct tagaataata ttagttaaaa taaagacaga gacggcaatt cgtcttttcg 2131681 tcttttcaaa aataaatgtt gtcagaaccc acagaaacca cattgaccaa tagtaataaa 2131741 attgttccat tttacttcct ccatattccc agtatggagt tcaagcacat tttttaaaca 2131801 atcgatctca cattaaggag tatgatcatg ggaaaagaca gacaagagaa aaaactcaaa 2131861 gcttcaggca gagtcgaatc agatcgcgac cagtccattc actatgacgg agcgacaagc 2131921 cttgaacaaa acggaagatt caaaaagcga aaatcataat acaaaaagcc caaaccacat 2131981 atggttttgg gcttttatca tttatcgcac actatagctt gatgtattga cccctctctc 2132041 tgtgagccaa tgatgggttt cacctttgat cacaaggggc gccttttgta aatcggcaat 2132101 tgttctggca cccagcacgg tcataatcaa ctttaattcc tcaaggatca gctgaatctc 2132161 ctcaagcagt ccttcctcac cgctgtcagt cagcgctttt aaaaaatgcc ctgccattcc 2132221 ggtgcaagag gcccccagcg caattgcctt tgccacgtca agcgcatctt gcagaccgcc 2132281 agaggcgatc atggtgcttg caggaaactc agagcggatt tccgccaaac ttgcagctgt 2132341 cgaaatgccc cacgaattaa aaaaggagat ttgccgctgt cttcggagat tttcgatttt 2132401 cgagaaattt gttcccccgt aaccgccaat gtcaacagct gcagcaccag cttcatacag 2132461 ctttcctgct gatgctttgc tcataccgaa gccgacttct ttcacaatga ccggtacact 2132521 gacccggctg caaatttgtt caatgcgttt caatgcgccg ctaaagcttc tgtccccttc 2132581 aggcatcaca atttcctgaa tcacattgag gtggatctgc agtgcgtttg ctccaatcat 2132641 ctcaacggct tcctttgcct gagcagccgt tgcctcgctt cccaggttgg caaaaatcag 2132701 cccgtttggg ttttcctttc gaacaatttc ataggaaaga cgctctgatg gatcttttaa 2132761 tgctgacatt tgcgatccca cagcaagggg aattccagcc tgagaagccg ctcgcgcaag 2132821 cgatttatta atctcatatg taagttttcc gccgccgcca gtcattgcat tgataaaaat 2132881 cggcgaactg cttgaaagtt cgccgatttt tgtggaaata tctacttgtt ctaatgcaag 2132941 atcgggcaga ctgacgtgaa caaacgtaat atcatcaaga cctgtttccc gcttctggcc 2133001 gatggacaag gcatgattga tgtgttgtct ttttcgttct gctcgagtca cgtttatcac 2133061 caattatttt agtttattca gcttatctcc gatcagatct ccaagctgga agccagtgct 2133121 tgtttcttcc ttcgcttgat attgacggta atcttcctgg tcagctttag gcgtttcttc 2133181 aagttcacgc atgcttaatg aaatgcgctc ctcattttca ttcacatcaa gaaccttcac 2133241 ttttacagtc tgtccttctt caaggacttc atgcggcgtg ccgatgtgtt tattggaaat 2133301 ttgagaaata tgaacgagac cttcaacacc tggaaggatt tcaacaaagg caccgaagct 2133361 tacaagacgc tgtacagttc cttcaagcac atcgccaggc ttcacttttt cgccgatttg 2133421 gttccaaggt ccaggcagtg tatctttgat cgataaagaa atacgttcat tatcacggtc 2133481 aaccgataac actttcactt ttacttcttg tccctcttca acaacgtcag acggcttctc 2133541 tacatgagag tgggaaagct gtgaaatgtg tacaagtccg tcgatgccgc caatatcaac 2133601 aaacgcgcca aagtcagtca ggcgctgtac tttgccatca agtacacttc caacttcaag 2133661 agactgaaga agttcttgtt ttttattcgc ttgttcactt tcaacaacag cacggtgtga 2133721 aaggatcacg cggtttttat cacggtcaag ctctacaacg agcagtgaca gtgtttttcc 2133781 tttatagtca gtgaagtctt caacgaaatg tgcttcaaca agtgatgccg gaataaaacc 2133841 gcgaacgccg atatcaacga caaggccgcc tttcacgaca tctttcactt cagcttcaaa 2133901 cacttctttt gtttcaaatt ttttctcaag gtcttcccaa gcgcggtctg catcaacagc 2133961 acgtttagat aaaatcaaag catcgtcttc cacttttgtt actttcaggt caagctcgtc 2134021 gtctacttta acaacatccg atgctttctc tacatgaaga cttgataatt cactgattgg 2134081 aataataccg gattgtttga cattgataat ttctacatct acatgtttgt cttctacctt 2134141 tgtcacaatc cctttaacta catctccaac ctctggcact tgaacatcaa tttgattcat 2134201 ttcctctgtc atttgaataa cctccttggt ccaaacctac acagcttaat taaaacggtt 2134261 tgaaagctga acatataaca tgcccgcttt tagccgaata tgtattaaag aatcatccaa 2134321 aaaagttttt tgaatgatca ataaaaagtt ttattagtat taacttctaa taaaaggaca 2134381 ggtttgtcaa gcaataacat tctatcttcg ttgaaaaatt caaaaaaagt ggcatttgcc 2134441 atcctcagcg ggacttttgc tccacagcct cgaggatttt atcagctacc tcttgaatgg 2134501 aaagcgatgt cgtgtcgatt tcaagagcgt cttctgcttt acgcagcgga gatacttcgc 2134561 gctctgaatc aagcttgtct cttcttgcaa tttcctcaat taatgtttcg tagttgacat 2134621 caaagccttt tttcacattt tcttcataac ggcgtttcgc tctctcttcc acagatgcca 2134681 aaagaaagat ttttacttct gcatttggca gcacatgcgt cccgatgtca cgaccatcca 2134741 tgacgacgcc gcctttttcc ccaagctgct gctggcgttt caccatttct tctctgacac 2134801 ttctgtgctt ggccgcaatt gaaacttggt tgctgatttc atctgttctg atcgcctcag 2134861 ttacatcggt gccgtttaca aacacttttt gtccatcttt tgttgtaatc agctcaatgt 2134921 ctgtccgctt tagcagctca gccagttttt cttcatctgt cagatcaacg ttttcctgta 2134981 aagccgcgta cgtaatcgcc cgatacatcg ctcctgtatc aatatatatg tacgattttt 2135041 tctcagccac aattttggca acggtgcttt tccccgcagc tgccgggccg tcgattgcaa 2135101 tcgataattt cttttccata attcctctcc ttgctctttt ctcctctaag gattgtatca 2135161 cgaactttat gaaaaagggt gaaaaattga tgaataatta atgtttgaag gtttcaatcc 2135221 tattgttttc ctccatttta tccacccctt catattgaat cacttttgat acgtatggtt 2135281 caatatgctg atagtgaaaa agaaattgga caccaagtaa aatgatggcc tgaatgaaca 2135341 ataatttgat cagcagccgt tcaaatgttt tcattggagc acctccatta caaatagtat 2135401 ggaagtgttt gccgatgttt attccattcg ggcctttctt ctcttattta actggcgcct 2135461 gatgcagtat tgaagcaaag cctgctggtc acctgctgca atttctgaat actctaaagt 2135521 catttttcgt ttttctgact tggggtcatt aaagattcgt ctgacaactg cttctgtttc 2135581 tatttgacgt gtgtgctcct cttcaggaag acggatgatc aggcgcaatg attcccccga 2135641 ttgaaaagaa aggccatcag ctaaaaccac ggcgatgccg cctgcactga tgttatagga 2135701 tagtgtgcgg atctcttctt catttcccgg ctgaatttgc acatctaata ccgcatcagt 2135761 tcttacatat tggcggcgct ggattctttt cattttttca cggggaggca tttcaagaca 2135821 gatcatttga agtttgtcct tcactttacc ttttatacgg cttataaagc gataaggaac 2135881 ttcgtctttt cccacaaact ctaccgttac ttccatatcg ttatgtaaaa tcacagttcg 2135941 ccctgtaact acatcaacag gatacgcgat caaaagttca ttgttttcga tgctgaccgc 2136001 cttgcttttt gcctttttca attcattttc ttctatatat tctaaaagta cattttctcc 2136061 aatctctatc attgacttca ctctttcgca ttcaatatac tcacgttttt attaaagcac 2136121 gtaatgaaaa aaaggaaaag acatttagtc ctttcctcct gtttttatag gtctttatat 2136181 ataggttctg cattttttag tttttcaacc ttttcttccg atccgtcttt ggcattgata 2136241 tacattctga atgtgtcatt ttcaattgtc ccaagcattt cgtagcataa cacttcttga 2136301 cctagttcat ttgtaatcaa agcgagcctt gtttctctca cttgtacatt tttatttaat 2136361 ttagactttg cctctgcttc agtaattgca ggcttaggta tggttctttt tctgtgagat 2136421 gtgaggaagt ctcttgctga aaagccgaca acctcaccgt catccaaggc cactttcata 2136481 cgaattgcct cggggtacat ccggacttta ttttcaacag gaacatatga aaatacaccg 2136541 attttatcat attgggcact ttcatcaatt tccaaatcat ctgtttcaaa tccgtttttc 2136601 tttaaaaatg caagcgctcg gttcgatccg tcatttaaac tgattttctg atctttcact 2136661 tctctgtttt ggatcaagta taccggatgc ccgcccttct tcgtaatatc catataaatc 2136721 actgctttat ggtctgggtc tttcatgctg atgctatata catcgcgatt tgtttttttt 2136781 ccgctcttta ccactttaat tgaataattg tcatctgggg caaagcgctc agcaatttgt 2136841 tttgcttcct gttcggaaat ttgttttccc ttcagatggc tgaagccttt ctcttctttt 2136901 ttcgtactgg tgaaactcgg gccaagatca gtgccagtgg agaatgcacc aacatttttt 2136961 tcgactgttt taaagctgtt gataatcgta ttatcacttt gtttttcgtc agaagccaga 2137021 gccatttcta cgtccatcca gcgaaggttt ttgctcatga caaggtgctg aacatgacgc 2137081 aattcatttt gtatatcttc ggactgctga tatagcttat ttagtgatgt atactcgttt 2137141 ttatcaagcg gcttttggtc caaatctctg actgacgttt tatagctgaa atcgccgatc 2137201 tttgataata gctcttcagt tttattaaac ggcattaatg taagcggcag ctgactgacg 2137261 ctgttatgag cttctgatgt aatcctccac acatcgatca atgcaggcga cagtgatttt 2137321 tggctgttca tggcaagtgt tgttccgatt ttatcatgaa gctgatccac ctgataggta 2137381 agctcatgaa acgcccgctg atagttattt tcagcatgaa gaagaactgc gtctttttcc 2137441 tggtgttctt tgtatcccca gtagcctgta ccgactattg caataccaag cacggcgatt 2137501 aaaattcctc tgatcattta tcacacctct ttttatgctt tctcatatct gctactcaca 2137561 gaaaatgtgt ttaccgattc ttttaatctg cggacgcccc caaatccacg gacttgtagc 2137621 cgtatccgga ttaaagtagt aaagtgcttc ctctgatggg tcccagccat tgatggcatc 2137681 cagcactgct tctcgtgccg tttcattcgg ctgcatgtaa atttgtccgt cggctactgc 2137741 tgtgaaggca agcggctcaa aaataacccc cgctactgaa tttggaaata acgggctgtt 2137801 caaacggttt aaaatgactg ctgcaatagc aacctgcccc tcgtacggct cgccccgggc 2137861 ttcgccataa accgcttgag caagcagcct gatatcgttg ttggaaaatc caccaggcat 2137921 gttcgctgct accgcatcct gttttcttgc ttttgctggt gtattgtttt gctgtttatt 2137981 cgcattcgct ttaggcttct gcgttgtttt ttccgcaggc tgtttctgcc gtgcttctgc 2138041 ttgttgtctt gccttttgtg ttgctgcttt tgatggtttc gtctgatact ttagcggaat 2138101 ttttccgtaa tgcgtgaatg tattcccttt attgagctgt tccatgacat attcacgata 2138161 gtattttgat ttacatatta aggtttgctt tgttttagct cctacaaggc cgtcaacctc 2138221 ttttaacccg aattgatcct gaaaatttcg aactgcccag tacgtccccc atccataaac 2138281 cccgtcaatt tttccgttat aatatccgtt gtattgaaga cgcgcctgaa gctcgaccac 2138341 atcatcccct gttgcccctc tttgaatgac ctgattcgaa aaggcagaga tcgtttcagt 2138401 attaataaac gtcgttattg taaaggaaaa aaggatgaga catgccataa tcgatccttt 2138461 ggacttcatc ttttcaagcc tcctactgca aatttttaag tgtaatcgta ttttctgtaa 2138521 cgaggttatt tttatacact ctttccttgt tatccctcag aacataaaaa ctgcacacaa 2138581 aaaagccgca cggttgctgt gcggcttcta tacttgcatc atattaacgg aacgggcttt 2138641 tttcgcttta cgcaaaccaa accaccataa aaataccata aatggaagca tataataaat 2138701 ccaattgcta agcgctgtta ggataaaatc atatgatcca tgcaaaaggg atgggacaac 2138761 taaagaaaga gtaagccact ttacacgcgc cttatcagcg gaaaaacggg cttttccaag 2138821 gtaaaatccc attataacgc caatcaaggc atggcatgaa acaggcagca gcgccctgac 2138881 aaacgcatgc tccacgccgt ggccaattaa ataaagaata ttttcgaggg ttgcaaaacc 2138941 gagtgataca cttgcaccgt acacaatccc gtcataatgc tcatcaaagt gggcgtgcgg 2139001 gtaaacactg atcatcagta taaaccattt taatgattcc tccaaaaacc ccgaagataa 2139061 aaaagaaacg aaaaagcttc cgcctcctac attctctttt tcaagtacat actggataaa 2139121 catgatggga aatacaagaa caaccccgag aaaaaacgac cgtagcacca tatgtacagg 2139181 ttcattatca tactgatctt ttaaataaaa ataacttaat aacgcgatgc cgggggcaat 2139241 tcctgcagag atgattgcaa acatcaggca acctctttcc tttatattcc tacatctatc 2139301 ctaccatgtt gtttaaaatt ttacatctgt ctgcacttaa aaaaacaaaa agagcatacg 2139361 aatgcatcat atgctcctca tctttaatgg ttttctcttt tggcgatttc cgctgcgata 2139421 tgccccccgt gaaacctgcc gttttcaata aatatttcat ttgcattgtt tcccgcagca 2139481 ataacaccgg caataaagac accttcaacg ttcgtttcca tcgtttcttc gttgaaaaat 2139541 ggacgccctg tttctttatc aatttcaaca ccaatttttt caagaaattg atgatcggga 2139601 tgatagcctg tcatggcaaa tacaaaatca tttttaatgg taatgagttc tttctctccg 2139661 gagcgaaaca caacttcatt ctcggtgatt ttttcgacac aagctccaaa ttccatacgg 2139721 attgtaccgt ttctgacgag agcttcaaat tccggcagaa tccacggctt aatgctcgga 2139781 gaatactcat tgcccctata taaaactgtg acacgcgccc cagatttcac gagttcaagg 2139841 gcggcgtcca cgcttgaatt tttcccgccg atgacaacaa catctttatc aaaatacggg 2139901 tggccttctt taaaataatg aaatactttc ggcaaatcct caccgggtac gcccatatag 2139961 tttggatgat cataatagcc tgtggcgatg atacaatatg gcgtcgtgta ggtctctttt 2140021 gacgtctcaa taacgaatgt gttattttgc gttttcgtca ctttacgcac catttcaaac 2140081 gcattaacac ggatgttttt ccgtttaacg acttcccggt aatacgataa agcctgaatt 2140141 ctgacaggct tcctgttctc tgtaataaat gccacatctc cgatttcgag cttttcactt 2140201 gaactgaaaa aggtttgatg cgtcgggtaa ttgtaaatac tgttaacgac attgcctttt 2140261 tcgatgacga gggcatcaat gccaatttgt tttaggtgaa tggcagcaga tagtccacaa 2140321 ggtcctccgc ctataataat tgctttttct tgaatcattt ctgtcaactc ctgcgattgg 2140381 catttcactt catattttct atttccgaat aaaaaaatct cctattttat cataggagat 2140441 tttttatttt tatgcaaatc atcaacttat atccagcctc taaaacgcga agcttcagcc 2140501 attttgcgaa cgccgaccat atatgcagcg agcctcatgt caattcttcg gttgttagcc 2140561 atttcgtaaa tattgttaaa tgatttgacc atcatttttt ctaatttttc ttctacctct 2140621 tcttcactcc agtagaagcc ttggttattc tgaacccatt caaaataaga aactgttacg 2140681 ccaccggcac ttgccagcac gtctggtaca agcagaatgt cccggtctga aagaattttt 2140741 gttccttcaa gcgttgttgg tccgttcgct gcttcaacga caattttagc ccggatatta 2140801 tgggcatttt cttctgtaat ttgattttca atcgcagcag gaacgagaat atcacaatcc 2140861 agctccagca gctcttggtt ggtaatggta tcgttgaaaa gctttgttac ggtaccgaag 2140921 ctgtcgcgtc ggtcgagtaa ataatcgata tcaaggcctt ccggatcata aagtccgcca 2140981 tacgcatctg agatgccgac aacttttgcc cccgcatcat gcataaattt tgccaaatag 2141041 cttcccgcgt ttccgaagcc ttggacaacg acacgcgcac ctttaatatc gatgcctctc 2141101 ttcttagccg cttctttaat acagatggta acaccttttg ctgtcgcaga ttctctcccg 2141161 tgagatccgc caagcacaag cggtttgcct gtaataaatc caggcgaatt aaattcatca 2141221 attcttgaat actcatccat catccaagcc atgatttgtg agtttgtaaa tacatccggt 2141281 gccggcacgt cttttgtcgg gccgacaatt tggctgatcg ctctgacata ccctctgctc 2141341 agacgctcca gctctctaaa cgacatatcc cttggatcac aaacaattcc gcctttacca 2141401 ccgccatatg gaagatcaat tatgccgcat tttaaactca tccaaattga aagcgccttc 2141461 accgccttca cctctttttc tgttacgttc gggtgaaaac gtatcccgcc tttcgttgga 2141521 ccgacagagt cattgtgctg cgcacgatat cctgtgaaaa tctttactga accgtcgtcc 2141581 atacgaacag gtatttttac cgttaataat ctcatcggct cttttaacaa ttcgtatacc 2141641 tcttcgggat atcccaattt ttccagagcc ttatgtatta cggtttgggt tgattttaat 2141701 acatcaagtt tgtcctcttc tgtatgaccg gtgtttcgat cggctgccat ttgagttaac 2141761 ctcctagaat cttctgtttc tcacatgctc cctttcagag aatagtatac accttcatat 2141821 gatctgtgca tagaataaac gttatgtttt tccatgtttt ttaacgaaaa aaaactgctg 2141881 aaatcagcag ttttccgttg cattcttatg aaaaatgagt ttgtatcgtt tctacggcat 2141941 taccgtccat aatgagctta ccatactctt gcaggcgata aatcgttaaa gttgtcggat 2142001 tgccgtattc agccagaacc gccacaaccc cttcagccgt atgtgaccct agatcttcaa 2142061 ggcttaaaaa gtactgcccg tcatagtggt agacagttcc ccctgtgata ccgattcgct 2142121 gtaagctttc tgaaagctga atgatatctt caaaggaatg gaattgatat atgatgtccg 2142181 cgctttcatc aagcttgact tgcatttcga tgtaatcatc atcatactca tcgtcttctg 2142241 aatcggcgtc ttggttcttt gttacaatca cgaccatccc ttgtgcttgg agagaataca 2142301 cttccactgc aatcggtcca ttcgcttcaa agccgagctc tgtatttgct tcattcatca 2142361 tatctttaaa taactggtgg actttaaatg agtccttcca gaggtcttct tttgtcaatc 2142421 cccggtctgt caaatcatcg agggttaaaa agattttgat cttattataa ttcagacgct 2142481 caagccgcat aacgttccct cctgcctcta cttgcacaca aatcatataa cacattatat 2142541 gagatgatga gtcataggtt cttaattgtt atcagtttac actgagttca ctagtaagac 2142601 aagcacaatg cagtttttat tgccatacgg atttttgctt tttagaagtt attctggccc 2142661 gcaaagagtc acaatgtgag tttcaggctc agcacctaaa cgaagaggca cttttgtcgt 2142721 gccgtagccg ttgctgatca gatatgccgc gtttttaaca atacctgttt tccccagttc 2142781 ataaggaccg aattttccaa acctgatctg gcctccatgg gtatgtccgc tgagtatcac 2142841 atcaataccg tcatcttcat tgatttgttc atgaatctcc ggattatggc aaaccagaat 2142901 attcagctgg ctttcatcaa gttctttgat ggcttcctca taatgatcca tctccatcct 2142961 gatatcatca acccccgcaa tcgcaatcgt atgcccattg tatgaaaacg ggactgactc 2143021 atttctcaga gtgatgacgc cgtgcgcttt aaatatggaa tacagcttat gctgcctgac 2143081 ttcataatca ttattccccc acacaaacac gatagggacc ccgaaatgta cgagcctttt 2143141 gatgttttcc tcgattctcg cactgggcac cccgccctca gctaaatcac cgccgattat 2143201 aaccaagtgg ggggcatggc ttcgcgcttt ttctaaaagg tcttgatcga tgagacgttt 2143261 gtgaatgtct gaaataaaaa agattgtcag aggcggcttg cccttcatct ttgataaagg 2143321 aaacgtatgt gtcttcaaat gattgccttt tgctgttgca tacatttttg ccgtcattgc 2143381 cgctgccgca acagttagta caccggcaat tttcactgat agcttcataa aaaactctcc 2143441 attcttttta gaacttatca ataagacgga caataaaaaa agacgtttct atcgtttgag 2143501 aaaacgcccc attttattta ctttcaaaat atagattaat gtcatatttg tgcttcatca 2143561 tatgaaaaac agactctctc gccttccatt tatcgggctg cggccagaga tcagtgcttt 2143621 tctgaataat ttcacatctc agtttatgga aatcagtctc ggatttttct tcctttttct 2143681 tgaaataata tgaagtgcag taggcaaaag cggttgccag catccaaaat aaataaaagg 2143741 tatggctaag tatttcttga agtataagct gaggctccgg gcttttgatc atgatcataa 2143801 cacataataa gcctaggcag ataagtgaag cccatcgcca tctgcggcat tgtgctgcat 2143861 aattttcgaa tttttgtttt cgttttacca gcgcttggag catctgtttg gtcggcgcgt 2143921 ctgtaaactg atccagctga ttccataagg attccatacg cttcacacct tgtccatttt 2143981 cattgctaca atatatgaac gtaaaataaa aataataccc tattcatcca ttaaagggat 2144041 gtccaaaact tgtccggtgt aaacatcatt tccattcaga tgattatatg ctcgaatttt 2144101 ttcttctcct gtccggcttt tataatactt catggaaatg cggtatagcg tttctttctt 2144161 ttggacggtg tgcttgacaa cgcgattcgg cacattttga actggctcag ctggctgttc 2144221 ttgctgttgt actgttgatt gggaagagga agcagccgcg gcggttgctt cctccttatt 2144281 tggcgagtct tctttttccg ctacagcagt ctgtttctta tcagcagctg tttgctcttt 2144341 tggcttggaa tcttctggct ctttttttga ctccttctgc agtgcggttt ctttagtgtc 2144401 tgcggtatcg tttttatcct ctgatttcgg gacaacctca tatttgcttt ggctgctgtc 2144461 aataaaaaca tcttcataat cgtcatgatt atccgggtgg ctctttagat aaaataaggt 2144521 gactaaaacg ataaccggca caaatacaaa tattactgcg agtactgtga ataatggcgt 2144581 ttttgttttg ccttgctttt ttttctgttc tctttgattt tttacagatt gtcttgtcgg 2144641 aaggctttct ccatcatcga cataatcgtc cgccaatgcg gcgttttgat cttcataaag 2144701 attctgggct tttcttctct ctactctcga catgttcgtc atgtttatcc ctcctcacat 2144761 gttcaaaacg aatctgacag gcaaacacgg catcaatgat aaaatgcgcc gtcatcggaa 2144821 caaataagtt gccggtccat tcatacatca gaccgagcaa aaagctgatt gctgtcacca 2144881 taataaataa cagccatttt gacaaatacc gaaagtgcag agcggcaaat ataaggctgg 2144941 ccgtccataa accgatatga gtctgcagca ctcctctgaa taacatttct tccgcgaaag 2145001 caatcagaag cgttaaaaat ataatatgag ggattgacct cttactgaat atttttttat 2145061 tgattccgcc gtcatcatat aaatgagacg gaaaccattt cattactgcc atatcggcta 2145121 aaataacaat aacagctata gaaacaccat accagatgat tcgcatatcg cgaatgtccc 2145181 agagctttaa tacgtcccgt acatcctcaa aaaagaacag tcctgctgca gcagcggcaa 2145241 agatgatgag tagctgcgtc aaatataact gcttcagcat atcatggtca gtcatatgct 2145301 gaatataatc tttttgctgt ttcagttcag ctcacctaca gtctgcaagc tgaatatccg 2145361 gtgcaattcc gaactccagc tgtctaatgg cgccatttta ctccgttccc ctttttgttc 2145421 atacaaggat aaatcaaaac cgcaatgtga acagcacggg aggtttccgt catcaggctc 2145481 gtatgattca tcaaagtagg ttaacagtgc ctgccttaaa cagccgtcac gctgaagcaa 2145541 aaatgataca cggtgcattt tttccagctt cagctccatg cgatatgaaa tttctttctt 2145601 catcagttca actgatgttt ttccctgcat aaagagatga atcatcatac gggcctgtgt 2145661 ctctccgacg ccatactgaa gtaatacgtc acgcagcctt ctctcatccc gctcctccgt 2145721 cttctctagc acacggatta cgtcggcgat ttcttcagct gtgacactct ccatctggat 2145781 aatttgttcc tgcaattcaa aatcccctgg cgcccgcagc aaaatgctga cactcggctt 2145841 tccgtcgcgt cccgctctgc cgatttcctg cataaaagct tctgccgtct gcgggagatg 2145901 aaaatgaatc acatatctga tatcaggttt atcgacaccc attccaaacg cattcgtaca 2145961 acatatcaca tcaagctggt tatgaataaa ctgctgctga attaaaatcc tgtcccctga 2146021 ctccaaaccg ccatggtaaa agtcggctct gctgctcgtt ttgcttttaa tttcacccgc 2146081 taattcctta gcccatttcc gtgttggaca ataaacaatt cccggacctt gcaggttttc 2146141 aaccagctga atgaccctat ctattttttc ggcagtatcc gccgcatttt caaccctcag 2146201 tgcgatgttt gggcggttga ctgagttgag atggcgtaca gcatgctgca gctccagcag 2146261 gttcatgaca tcttgcagcg tttcctttgt agccgtggcg gtcaatgcca gaacgggtgg 2146321 gtgtccaagt ttttttctca gctgtccgag ctttgaataa tcaggcctga agtcgtgtcc 2146381 ccattcagaa atacaatgcg cttcgtcaat aacaaatagg ctaatcggaa cgcttttcaa 2146441 tttttccaat acatatggag actgtaaagc ttcaggagac aagtacaaaa atttatatcg 2146501 atgaatatgt tctaaaacaa attgtctttc ctgcctgtta agcatgctgt tcaaagctgc 2146561 agcacgcttt tccccccggg ctttgagctg ctgcacctga tcctccatta aagaaagcag 2146621 tggagaaacg attaatacca tgccatcaag catataacca ggcagctggt agcaaagcga 2146681 tttccctccc ccagtcggga gcattgcaat ggtatccttc ccgctgagta tgctttcaat 2146741 aatgtcctgc tgcccttttt taaaggaagt aaaaccaaaa aactgatata acgtttgctg 2146801 taatttagtc atattgctgc acctgctttg tcaatgccag tctgatttga aagtagctga 2146861 accgctgttc cagcccgtcg cgaatttgtt tgattttatt cgtccgcatc cgtttggcaa 2146921 actctgcgat ttgaagctgg tcttctgctg atacatagtc attaatcata aacgcaggct 2146981 catggagaga aatctcgaca atgtggtctt caatcgtcgc tgttttcagc tttctgattt 2147041 cagcaattcg ctgtatcgga aacccttgtt tgaccatctg ccatgttttc ctcgtcgact 2147101 ctgtcagggc attatctaag tgcacatcag aaaggagatc ctttaacaaa gcatcttcac 2147161 actccggaag agaatgaata aaataatgta ccgaagccca aaacatgata tagacatacc 2147221 attcgtcttc tttcagcgta tcagcaagct gcctgctcgt ataaccgatc cgatggtgcg 2147281 aggttaagga gtagacaaaa atttgcgctg ctttgttttc aatctttttc aaatgcgcct 2147341 caagcatggc aaaaaggctt tttgccatct ctatatgatc cgtatgccgg gacaggtatt 2147401 tctttaccca gtgaagtgtc ttatgatcct ttgtgacagg gatatactgc ctgctccctt 2147461 gctgtttatg ggataggacc tgcacaagca gcgaaagcct tttccaaagc acgccggcag 2147521 cctgctgata atgagcgccg tgacaatgaa cgggccaagg ccgctcgcta agggcatgtc 2147581 tcaaaactgc tgcgccgctg gctgtcactt tgtatgtatc tgattcagac attggcgcga 2147641 gatatgaatg cttttcaagc ttgtcaagcg acgcagaaat atcgcttctc gaacattttg 2147701 ccgccattcc aaagtatttt gcagtctgaa ataagccggc atcttgaatg gtctgtgacg 2147761 atctcttgcc tttgaatagg tgaaaaacag cgcttcccga ccgttccccg tttattttgc 2147821 aaagacaatc gagaaccata atatcgaagt aatttaatga caacctatcc acctacattc 2147881 ttcctgacaa aaatcgttga tttgctcttt ttattttaac agatttcaaa cagaaatcga 2147941 cgtttaaagt catcattaag ggggatgtta tgtagataac cccttatgtg ataagcattc 2148001 tcaatcattt ttctgttgaa atgtggcagc aacatcatta caataagtaa gaggaatagg 2148061 tgttaaattg attaaatata aagattgatc catttgttcc accaagaaca atctgggagg 2148121 ttttattcat ggcaaagtac acaatcgtag acaaagatac atgtattgca tgcggcgctt 2148181 gcggagctgc tgcaccagac atttacgatt acgatgatga aggcatcgcg ttcgtaacgc 2148241 ttgatgaaaa caaaggtgtt gtcgaagttc ctgaggtact ggaagaagat atgattgacg 2148301 catttgaagg atgccctact gattccatca aagtggcgga tgagccattt gaaggcgacc 2148361 cgcttaaatt tgaatagaag taactaaaaa aagctcccga acgggagctt ttttatttaa 2148421 tggatatgtg cacttcgctg ctgctcaatc catggcttaa gcttgataaa aattagtgag 2148481 aatacaaccg taattacaat accttttatc atgttaaacg gcaggatacc tgcgacgact 2148541 gctgttttta gcgcgctgtc ggataatgcc ggtgaatgta aaaaccacgt gtatgccgga 2148601 agaatcagaa cataatttaa aatactcatt aaaatggtca tcgctgcagt tcccaaaagc 2148661 aggctgacag ccaagccctt tgctgagttg agttttttaa ataagaaagc agtcggtaat 2148721 ataaagagtg ttcctgcaat aaaattcgca acttgcccta caggaactcc ggccatgctt 2148781 ccctgaatga tatactgaag aacatttttt atcgcttcta cggcaatacc cgccaaaggt 2148841 ccgtaaatca gaatggcaat aattgcggga acgtcgctaa aatcgatttt taaataatcc 2148901 ggaagacccg gaaacgggaa atttaacagc atcaaaacaa atgcaatgct gctcagcatg 2148961 ctgaccacaa ctaatttttt tactttcact tcattctctc cttttcgatc acatcttact 2149021 cgaaaacgga aaggttcttt tccagccaat aaaaaaaccg cttcatatat aaaagcgggg 2149081 tttcgaaaat taggctaggc aaagaaacgt ttgaaaaatt caatttcaaa acgcttatga 2149141 acctccatct tctcccatcc agactgtact gtcggctccg gaatctcacc gaatcctgct 2149201 gtaaagacag ctcgcgggct tagagccatt ggctcatcac cgccggtagg gaatttcacc 2149261 ctgccccgaa gattgatcat atgaaattta attacattat aaacgataac tggttggctg 2149321 tatagagaat tgcttcaaat taaatatatt acctgcaagc tgtcagatca ttgatttatt 2149381 aggctttact tttatccttt actgcgtcaa tacacgttga cactcttttg agaatatgtt 2149441 aaattatcag atatttagtt tgtcaattta ggaggaaatc taacgatgtt tcgagtattg 2149501 gtctcagaca aaatgagcaa cgacggttta cagccactta ttgaatcaga ctttattgaa 2149561 atcgttcaaa aaaacgtagc agatgcagaa gatgaattac atacttttga tgctcttttg 2149621 gtgcgaagcg cgacaaaagt aacagaagac cttttcaaca aaatgacttc tttaaaaatt 2149681 gtcggaagag ccggtgtcgg tgtcgataat atcgatattg atgaggctac gaaacacggg 2149741 gtaatcgtga tcaatgctcc gaacggcaac accatttcga cagctgagca tacatttgca 2149801 atgatctctt ctttaatgag acacattccg caggctaata tctcagtgaa atccagagag 2149861 tggaaccgca cagcttatgt cggttcagag ctttatggaa aaacgcttgg tattgtagga 2149921 ttaggccgaa tcggaagtga aattgcacag cgtgcgagag cgttcggtat gactgtgcac 2149981 gtttttgatc ctttcttaac ggaagaaaga gcgaaaaaaa tcggcgtaaa cagccgtaca 2150041 tttgaagaag tgcttgaaag tgcggatatc attaccgttc acacgccttt aacaaaagaa 2150101 acaaaaggct tattgaataa agaaacgatt gcaaaaacga aaaaaggcgt tcgcttaatt 2150161 aactgtgcgc gaggcggaat tatcgatgaa gcagcacttc tcgaagcttt ggaaaacggg 2150221 catgttgcgg gagcagcgct tgacgttttc gaagtcgaac cgccagttga caacaaactt 2150281 gttgatcatc cattagtcat tgccactcct cacttgggag catcaacgaa agaagcacag 2150341 ctcaatgtcg ccgcccaagt gtcagaagaa gttctgcagt tcgcaaaagg cctgcctgtc 2150401 atgtcagcta tcaacctgcc tgccatgaca aaagatgaat ttgctaaaat taagccttac 2150461 catcaaattg caggaaaaat tggcagcctt gtatcacagt gcatgaaaga accagtacag 2150521 gatgttgcca ttcaatatga aggcacaatt gctaaacttg aaacatcgtt cattacaaaa 2150581 gcccttctgt caggcttttt aaaaccgcgc gtagactcta ctgttaatga ggtcaatgcc 2150641 gggggtgtcg caaaagaacg cggcattagc ttcagtgaaa aaatttcctc ttctgaatct 2150701 ggatacgata actgcatcag cgtaaaagtg acaggagacc gcagcacctt tactgtaacg 2150761 gctacgtata ttcctcattt cggagaacga attgtcgaga tcaatggatt taatattgat 2150821 ttttatccga ctggtcactt ggtgtatatc cagcatcaag atacaacagg tgtcatcggc 2150881 cgagtaggac gtattctcgg agataatgat attaacattg caactatgca ggttggccgt 2150941 aaggaaaaag gcggagaagc catcatgatg ctttcctttg acagacatct ggaagataaa 2151001 attgtgaaag aactaacaaa tgtccctgat attgtgtctg tgaagctcat tgatctgcca 2151061 taattaaaaa aactcaagct atatagcttg agttttttta ttgttctatc cccgtgtgtt 2151121 tttatgcaaa atatctaaga cactccttag ctcagaaaca ggaatttggc ctggtgcgga 2151181 cgcctcttct ccagctccaa aagtacaagc cgatccaaaa acctcaccgc tcagcctgct 2151241 gatgagccct gttgcagcca ttgacattgt aataatgggg cggtctgcat atattgtttt 2151301 cattgtatac gtcgcatcaa gcagtgttag gagatctcca gtatcattcg gcatgacagc 2151361 catttttgga atatgcgcgc ctaagtcctg catttttcga agtctggaaa taatttcatc 2151421 ttttacaggt gttttttcaa agtcgtgatt tgacatcacc acatagacgt tgttttcttc 2151481 cgccagcgat actaacgctt ttacatttgc atctcctgaa aataattcga tgtctatcag 2151541 atcgatgtct tttgtttgga ttgccgattc cagcaaagca agataggagc tttcgtccat 2151601 ctccatgctc ccgccctctt tgtgggttct gaatgtaaat agaaatagct tgtcttctaa 2151661 agatttacga agcttagaaa tgagctttgt gaccgcttct ctgtcattcg ctttttcaaa 2151721 tacgtcgact ctccattcaa caatgtccgg attcagtaat tttactgcct ctgcttcatt 2151781 cagaatttgt ttttccgtct ttcccatcag cggaatgatg attttcggca tcccttcccc 2151841 gatggaaact cctttaatcg ttaacacgtt cactcgtctc aaatcctttc aatctttacc 2151901 ttgttttatt atacacgtac aacttttttt tgaaaatttc tattatatga atagcaacta 2151961 aaaaagagcc ttaaagggct ctttttagtt taaggaaatc ggatttggag cagctggcac 2152021 cggaattgca tctgatatgt catatttgcc gatttttttc gttctggttt ccgtaaaggt 2152081 cacttctgtg aagccaaact cttttgcagt caaaagtagt ccctcaatca ttaaaatacc 2152141 ggcaatagaa tcatcaactt ctgactcctt tgaaaagcgg atatataagt gtttctgttt 2152201 cttcgttaca gattggacag cacccgcttg aataagaggt gtcgtatctt cttggctgct 2152261 cgattccatt tccttaatcg cttcttttac tgtatcaaaa gaatgatttg acggaacgag 2152321 aaagtcttgt ccttgtttat tttggtacaa gtagtaggat cgttttgact gtttgggaat 2152381 cgaaatttcc gtaaaagtgc catatgagcc aatccgaacc ccagtctcat tttgatccga 2152441 taaaaatttg actttttcat aaggactcca ttttaaggat tctttaagca atttttttaa 2152501 cagtgtatca tcttttatag aaaatgccgt agctggctga tggactcgta tacttaattc 2152561 cttctgcttt ggtttttcct ttatttctac ttcatctatg aaggttggaa ttgtaatggc 2152621 atgatcaagg atgcccaatt cactactttc aaacagcata tcctggatcg tttggtctgc 2152681 atttgttttt tgaatgctga cgggtatgat tgcagatgta tcggcatcag caaccgctac 2152741 agtgatgtaa ttgtcttgtt ccttttcagg aacgacaaac gatgtctgat ccaaggacga 2152801 tgcagctttt gggctgtctt ctgtctcagt tttcgttact gcgttctctt gggacgcttc 2152861 tttttgttga ggctgtgcct gatcaaagaa atgaggagaa ataatgaagg cgatataaac 2152921 cgcaattgca gcggcacacg cggggccaat ccacctgaca gcgggcttat ttttacgctt 2152981 tgccatcgtc agccgcttgt aaatatcctg aggcgaacga tggtctttaa ctgccggaag 2153041 ttgacttaac aactccttta tctgttcttc gttccattct gacttcatca tccattagct 2153101 cctccctcaa aagctccata tgtttccgaa gtactttgag ccctctgtgt tgggtcgttt 2153161 ttactttgct ttccgagaag cgcagagcct tggctgtttc ctgtattgaa tatccctgaa 2153221 taaaccgcaa gataatcaca gctctttgat cgattgtaca ttgatcaagc gcagcataaa 2153281 tttcccggac attttcatgt tgaaccgcaa gttcgtccgg cagcaattgc tgatccctga 2153341 catcctgtgt atcccagtca aatgtaccga gtatacgctg tctgattgtt tgctgtttac 2153401 ggaaccagtc tatcgcaaca tggcgtgcga tagacaaaag ccatgttttt tcactgcttc 2153461 ttccttcaaa cgtatgataa gaatttaata cccggatata aacctcttga agaaggtctt 2153521 ctgtctggtt tttatccttt accatataaa ataaaaattg gtacaaatct tgatgatatg 2153581 tatcatataa taattgaaag gtttcttcca tttgaaaccc ctccgttcac ttttttgtcg 2153641 tatgaatagc ttgaaaagtt acattacaac tatattacga gtaactggaa tttggaaggg 2153701 aatttatatt aacatatcct taaattttat taatgttggc tattaaaaaa acacccgctc 2153761 agtcagcggg tgtttcttat ggaacaagat tcttcggcaa attcagactc gattttaccg 2153821 ttttgtcgga atataaaaag aaaatgttgt tcctttatct attcggctgt gcacagtaat 2153881 tgatccgttg tgggcttcca cgatattttt aacgatagcc agccctaacc cggttcctgc 2153941 tctgcccctt gtccgcgctt tatctgcctt ataaaaccgc tcaaagataa atggcagatc 2154001 ttcttccggt atgccagacc cggagtcttt gatatcaatt ttcaatccat ccttcacaga 2154061 atggactgaa atggagacac tgccgccggc tgaagtatgc cgcagcgcgt tatcaatcaa 2154121 attggtaaat acctgctcca tcttgtcttc atcaaacata aattcctctt ctgtgagaga 2154181 aatgtcatga tctaaagcaa tatttttttc tttcgcaaca ccggaaaact tccgaatgat 2154241 cttttctaaa aactcattca cattgatttt ttcataatgt aagcctgtat ggcctgattc 2154301 cattcgggct aaatcaagca aatcattaac taaacggccc attcggagcg attcgtcata 2154361 aatgatttgg gcaatttctt tccggtcttc ttcagagctt gcaatgtcat cgacaattgc 2154421 ttcactgtat ccctgaagca tggagatcgg tgttctcagc tcatgactga catttgcgat 2154481 aaagtcctcc cgcagcttat caaggcggcg ttcttctgtc atgtcacgca gtacggcaac 2154541 cgctcctctg acgtgcgatt ccgcataaag cggcgacatc aaaagcaccc atgatctgcc 2154601 ttgaagcgtc atctcaatca tttgttcttt ttcagtgctg acagcgtttt gaaacagctc 2154661 ttttgcttca ggcggaagat tgtcgccttc tttgatattc atgttctgtt cataatacca 2154721 agcctgaaga aaacgttcag ccggcgggtt ggtcacaaga atcgtaccgt caatattaat 2154781 ggtaataacc ccgtcagcca tactgctcaa aatgttagaa agctgctctt tttcttgatt 2154841 gagcgcattg atatgaaagt taagctgccg gcccatttga ttaaaagcgg tcgccagttc 2154901 accgatttca tcctgagtta aaatcgggat ttttgtatcg aacttgccct tcgccaaatc 2154961 ctgcgcgcct tctctcattt ttcggagagg gtacgtgacc ctgcttgata aaaagaatgc 2155021 gaaaaatgtg gtcagcacaa tcgcaattcc agcggcaaga aaaatatagc gggtcgtatg 2155081 ttttgttgta tctttaacgg caagcaaaga ctgggataaa aagaccatgc ctttctttcc 2155141 gtctttttca tacgggacac ctacaatcag gcgttcatta tccgtgtctg tatcgctcag 2155201 tcccgtccgt ttgcttactt ttttatggtc tttgagagct ttatttaagt ctttgtcatg 2155261 ctgtatttgc tcaaccgtaa tagacgacag gcgattttta tcattcggag aataccagtg 2155321 gttcttctca tcctggatga tggcaatgct tgttaagtta tcagcgagtt cccaagtgat 2155381 tgaccttgcc agtgcctggt cctcgtgatt ttctaggatg acagcaactt tattcgcaag 2155441 ctgtgttaaa tcattctcag cttcttccac atggtagttt tcaataaact ccagcaaaag 2155501 aaccgttaaa atgaacaata cgatcaagac gagtgaaagg atcgtaaacc acagcttgcc 2155561 tactacgctt ttccaaaatt tcattcagcg ccgacctcaa atttataacc tacaccccat 2155621 acggtgacaa tttttttcgc agcttccgga gataccttgt tcagcttctc tctcaagcgt 2155681 ttgacgtgag tgtccactgt ccgtaaatca ccaaaaaact catattgcca cacttctttc 2155741 agaagctttt cccgatcata caccttgtca ggcgttttcg ctaagaaata tagaagctca 2155801 tactcttttg gcgtcaggct cacttctgtt ccatcagctg ttacgcggtg agcatcatgg 2155861 tctattgaca gatgtgaaaa cacgagcaca tttttcgtcg gtgtattggc attgaaataa 2155921 gaggtttggg atgctcttct caaaagggcc tttacacgca gcacgacttc tctcgggctg 2155981 aacggcttaa caatataatc atctgttccc gcttcaaacc cctgcacccg gtttgcttct 2156041 tctccttttg cggtcagcat aataatgggt gtcgcttttt tttcacgaat ttgccggcac 2156101 acttcaattc catcagtccc cggcatcatc agatcaagca aaattaagtc ataattggct 2156161 tcaagccctt tggcaatggc ttcatcacca ttttcagctt catctatagc ataattttca 2156221 cgttcaagat acattcttaa aaggcggcga attctggctt cgtcatcaac tactaatatt 2156281 tttgtttcgt tcgtttggtc catgttttcc ccctgctttc cttctgttac tttcatttta 2156341 tcaaatcgtg agaaagtttg agaactgtgt cgctttcaaa ggactatgca taagaatgaa 2156401 gtccggcaag cacaagattt acgaatatta aattaaacat aataatagca aaaccgatta 2156461 cggccagcca tgctgacttc tcaccgtgcc agcctcttga cagtcttaaa tgcaagtaag 2156521 cggcatagaa caaaaatgtg atcagcgccc atacttcctt agggtcccag ccccaaaatc 2156581 tggtccacgc gagctgagcc caaatcattg caaagatcag cgcgccgagt gtaaagatcg 2156641 gaaatccgat tgatacggcc ctgtacccaa cctcatccac cagatcaaga ttgacgtttt 2156701 tcaccagcgg atgtaataga gcgctgattc tttttctgat gatcagacgg agagccccat 2156761 acaacacaag acctgctcca aatgaccaaa tgacagtgtt cacttttctg cctgagaaaa 2156821 gcgcgggaag atcaacaagc ggttccattc ttccttcggt caaaagctct ccctgatgcg 2156881 gaccgacaag cgcgggcatt tcgtacacca tcacgctttt ttctttactt ttgtccaccc 2156941 agttaaactc cgcttcatag cctgcaagac gaaatgccga tgtgattgca ataaaggcga 2157001 cggttgtgac caggataaac ataatcgctt caagccagaa ggtctttttg cttggctttg 2157061 tctggtctac atgcttcaaa agaaagatga caccagcgac aaagctgatg gcaagtatag 2157121 cttgcccaag cgcggccgtt gttacgtgaa tatacagcca gttactttgg agcgaaggaa 2157181 ttaaaggcga gatatctgtc ggaaacatgc tggcgtaggc aatcagcaat aaagcaattg 2157241 acagcgtaaa caggcctaat gaaggcaatc tatagagaaa ataaagaatg ataaacgcca 2157301 aaacaagcat catgccaaaa gcggtggtga attcaaacat attgctgaca ggcgcatggc 2157361 cgcttgcagc ccaccttgtg atgaaatatc ctaggtggca gaaaaaaccg acaatagaaa 2157421 gggtgattcc aatgttggcc catcggtttg gcctgccctt tttatcttta ttcccgcgta 2157481 tggccccgcc gaagattggg acagcgatta aatacacaag aaaggccgca taaagaaaat 2157541 ttccgctcag ctctgccatg acatcactcc cttttcgcct atttctgtgt tttgattaat 2157601 tctttttggt ccaccggttc agtcagtccg gaatcagcca atataaatgc taaatccttc 2157661 ttcaggccaa accagttttt attggtatgc cctgctacca taactgcacc gtcctgtgag 2157721 tgcagccaaa ttcttcgatg ctgccagtac ataccttgaa tgacaccgat cataaaaatg 2157781 gctccgccga cagcaagcac ccagagtgtc agatcctttc tgactgtaag tccagtaatg 2157841 tttttcgttt cgacatggtc aaatttcagc ttgtatttat tattgcctga tccttcgatg 2157901 gtttcttgga tggcgacaaa gctcttttcg cctttcggtt tgtccggcgt tatgatatta 2157961 aagacaaaag ccggattgtt agggatcttt gtttttgtgc tcggctctcc gtcctgatta 2158021 aaatagaagt caggcaggta gctggcgatt tccaccttgt aaccgttacc aagatcatag 2158081 actgaatctg gatccagaag gttgatcttc aggctcccaa aggatttttt tgttttttta 2158141 tcaatcagct ggaacaccat ttggtcaagc tgattctctt tgtaatccac ctggtaaacg 2158201 gaaaaagaat caaaacgcag cggctgattg acacggatgt cttcttctgt tactttttcc 2158261 agcttcggct tctcgccata aacaattttt ccttctctct tgtagagtac ggcatcagtt 2158321 tgaaagttct ttgccactct accgtccccg actctgtcaa tggcatctgc aaataccttt 2158381 ttttccgttt tgctgttata ggtctctacg ctgaattgat tgtttttcaa ataatatttt 2158441 ccgtctgtac ccggaattgc tgcggtttcg ccttctctga cccaaagcgt ctcatcgacg 2158501 tacatgccag gcacaaatct cagcatcgca ccaatcagaa agatgatcaa tccaatgtgg 2158561 ttgacatacg ggccccagcg ggaaaagcgt cctttttcag caagaatgct gccctctttt 2158621 tctctgattc tataatgttt tttctttaat agagtaacta tcttttcttt cgattccccg 2158681 ttcagtacag taactgtttc actgaacaag cgctgccttc ttaaaaaggc cgggctcctt 2158741 ctgacacctt ggttttttaa cgctctatac aacggaatga cccgatcaag gctgcaaatc 2158801 acgagtgaaa tgccgatcga ggcaatgagc agcaaatacc accaagaacc atataaatga 2158861 tgaaacccga gcaaataata aagctggcca aacgtgccgt actgctcctt gtaataagta 2158921 tcagcctgtg cgcccggagg cagataggct tcctggggaa aaatggtgcc gaacgctgat 2158981 gcggcaaggg ttatgacgat aagccatatt cccaccttaa ccgaggaaaa gaaattccaa 2159041 attttgtcga tgatcgtttt gttataggtt tgcgaacgtc ttgcgcttcc gtcatatctc 2159101 atatcagcga gcggaggttg agtttcctga agagctcttc cgcacgattc gcataaaacg 2159161 gttccgaccg ggtttatatg tccgcattca catttgactt gcttcatccc gaagtctctc 2159221 cgggttttat gagattcata taatcgtgta tcatgctttc tgtcatagtg ccggtcacca 2159281 ccttgacaac ttttccttcc ggattgatca aaaaggttgt cggaagcgga gatacgtcat 2159341 aggcatcaag cacttggcga tctgtatcca gaacaaccgg gaaattgact ccgtaggatt 2159401 tcataaaatt atgtactgct atctttgact ccccaacatt tacagcgaca atttcaacac 2159461 cttggctttt aaaatgctta tattggtttg ccatataagg aaactctttt ttgcacggtt 2159521 cacaccatgt accccagaaa ttcaaaaaaa cacctttccc ttttaagtca ctgagctcga 2159581 tacgtttccc attcgtatcc tctaggacaa aattcggtgc gtcggaccct tcggatatac 2159641 tctctttgcc ggcaaataca gcgttgtaaa tggtatagcc gagtgcgcag attaaaacga 2159701 gaaggatgcc ggtccgaatg aataaacgcc tttttttctt cattgtccac tgcccccttc 2159761 cccctattgc agatccattc aattatatca ttgcacgttc atttcacatt tcttactttt 2159821 tgaaggttat gtgaaattta gaaagcgttt ttaccgtgat ccgccagtgc tctgagcctt 2159881 tttacttcgt gaggcgtaag ctctctggca tcgcccgtgt gcaggcctcg caggtttaaa 2159941 aacgcgtatt cctcacgctt cagcttgatt acctcatgtc cgatcgcttc aaacatgcgg 2160001 cgcacttgtc tgttgcgtcc ctcatggatc gtcagctgaa taatgcttgt ctgctttttc 2160061 ttatccaaag acagcagctt cgctttagca ggcgctgttt tgccttcctc cagcctaatt 2160121 ccgcgctcca gctttctgag cagctcttta ggcgggattc ctttcacctt cgccacgtat 2160181 gttttgtcta tttcatactt aggatgcatt agcttattgg cgaattcgcc gtcattggtt 2160241 aaaagcaaaa gaccgctcgt atcatagtcc agacgcccaa tcggataaat gcgctgcgga 2160301 atatttttaa aaaagtccgt caccactttg cgtcctttat catcttgcgc tgcggaaata 2160361 acgcctcttg gtttatataa gagaaagtaa accggctctt cgcgttcaac ctttaacccg 2160421 tttacctcaa tctgatcaga accggtgacc ttaacaccta gctctgttac tactttgcca 2160481 ttcaccttta cttttccttc tttaatcagc tcttctgcct ttctgcgcga cgcaactccg 2160541 gcatgagcaa tcactttttg cagtctttcc atgtctttca cctcaagtat tatcttactt 2160601 ttttcaacct taacaaacaa gctttttcaa attcctatgc caaatctaaa aaaaacgccg 2160661 ttttcaggcg ctcccaaata ataacgtaac gatgatgata gatgcaacta cgccgattaa 2160721 atctgcaaga agtcccacct ttaatgcatc acccattttt ttaatgccga ctgctccgaa 2160781 atacacagtc agtacgtaaa gcgttgtatc tgtagatccc tgcatgacgg aagccagcct 2160841 gccgataaag gaatcgggcc cgtatactgc aattaaatcg gtcgtcattc caagtgcggc 2160901 cgtaccggag atcgggcgga tcagagcaag cggcactact tcagcaggga tgccgatagc 2160961 ggagaaagcc ggttttaaaa gatccattat aaaatcaagc gcgcctgatg atctgaaaac 2161021 agttatagcg acaagcattc cgactaaata ggggataatg gaaaaggcaa tttctatccc 2161081 ctctttcccg ccttcgacaa acgattcata tgtcggaacc tttttgatcg ttccataaag 2161141 aagaattccg gcaataatga ttggaatcat ggctaaagac agccagttga tgatttccat 2161201 ccgctcacct tcccttcttt ttgcggcggt aataaaaata ccgatcaatg ataatggcac 2161261 cgattccgga aataagcgtt gccaaaatgc ttggcccgac gatatctgtc ggcgttttgg 2161321 aggaataagc cattcggaca gcgatcaccg ttgtcgggat gagtgtgatg caggacgtat 2161381 taacagctaa aaaagtaatc atcgaccggc ttgcttccga tcggtttccg ttcagctttt 2161441 tcatttgttc cattgcttta atgccaagcg gagttgctgc atttccgagg ccgaagaaat 2161501 tcgccataag attagataaa atatagccca tcgccgggtg atccggcggt atatcaggga 2161561 acagtttaga tataaaaggt ctgcacatcc ggctgaaaat atccaaaagc cctgactgct 2161621 cggcgatttt cattaagcca agccagaaaa caagcacgct catcaatcca aatgagatcg 2161681 taatcgcttc tttcgcaccc ttaaacacgg cttcatttac atcttgcaga gttccgttgc 2161741 acatcgcaaa aacgagtccg atcacggtta aactgaccca aattatattg accattttgc 2161801 tccgcctgcc gcattcagaa agattgattt aaacgtttca aaaaattgtt tcttcggttt 2161861 ttgatgccgc tcattttcat aatagatcgg cacttttgcg atggttgcat cgttgaacat 2161921 gatctccatg tgccctacga tgtcagggat tttcgaggca tctttttccc atgctttttt 2161981 cggcttgagc agtgtggtat taatttttac attttctttt tcctcttcgg tcagcaaata 2162041 ggtgatatca cgtttgataa aagccttcga ttcataaaat gtgcctttca gctttggaat 2162101 atcccctttt tttgcaatta aataggtttg ataatgctca aacacatagt taaacatctt 2162161 catatggtca tcccaatcat tagggtcatt aatggtgacg gctatcaggt caatgccgtc 2162221 ctttgaagcc gtagagacca gtgtccgttt tgcaagtttt gtatagcctg tttttcctcc 2162281 tgtgctgtac ggataaagca tggtcagcag tttgtttttg tttttccata cgctttccat 2162341 cgtttccgct ttgtatattt ttgtgcctga aatcttttga tagtctttca gcttcatagc 2162401 atacttagtt aaaatggcca tgtcataggc tgttgaataa tgattttcat ggtcgtccaa 2162461 tccgtgcggg ttttgaaaac gggtgttttt cataccaagc tgctcggctt tttgattcat 2162521 catataaaca aacccatcga ggctcccacc gacatgctca gcaatcgcga cagcggcatc 2162581 gtttcctgat cttagcatca ggccatacac aagatctttc agcttcactt tttgaccttc 2162641 tgttaaataa atggcggagc cttctgttct gacagcattt gccgaaaccg tcactgtttg 2162701 atccattttg ccggattcga tggcgaggac ggcggtcata atttttgtga tgctcgcgat 2162761 ccgccttttt tgatgctcat ccttggcata taacactctg cctgacgcac cgtcaataat 2162821 gatcgcgctt tttgcactga catctatagc agcatgtgct gtattcacat ttacggttgc 2162881 aataagaaaa gaaatcatga tcacgaatac tgcttttttg aaaatgcgca tgtttgctca 2162941 cgtccttgtg gtggtttgta caagtttatg cgcatgtcca tcagttatga ataacaatta 2163001 tatttctgga agcaaacata aaaaaactct ccctgaaaaa gggagagtaa acgttatctg 2163061 attggcgcca tgcttgatcc ggacgcttcg taatgagcca gctcttccct catcttcaga 2163121 aaggccgcgc tcaacggcaa taataattgc tcaagcgacg caggaacagc atgataaaac 2163181 tcaattgcgc tgaccccggt ataagacgcc cggctatttt cacaccacgt gtcttttttc 2163241 ggcataaaga actcttcaat gcattggtga tacacattat aaagtgtttt ttccgctctg 2163301 gcttcctgaa aaggctcctg catcaggaga cgacggcacg cttctgcgcc tccttcacaa 2163361 aatactgcca ttcttctcag agtgctaagc acatcacagc agtatccttt ttcaataggc 2163421 aattcagcct gtaaggactc aagcgtcgtt tgatttaggt aatcgttcac ggtattgaca 2163481 accattgata agaattcgcc tgttttttga gtctgcgctc gcacaatcga atgtcccatt 2163541 tcgtttggta tcttcccctc atgtatttgt ctctcacatt ttgcttcttt catgatagct 2163601 tcttccttat atcttatgat gatgaaaaag cgcgattcat taaacttcta ttttatatct 2163661 tcgaaggttt ggttaaagtt ttcaaaaaat aaatctgctt cttcttgaag aacgtcttct 2163721 tccgcatttt caggcagcgg cggaagctcg tccagcgttt tcagaccgaa ttgttcaaga 2163781 aaagtcggcg tagtaccgta taaaatggcc cgccccggac catcggcacg ccctacttca 2163841 cacaatagcg ccttcgcgac aagactgtgt aaaatccgct ctgattttac tcctctgatt 2163901 tcttcaattt ctgctctcgt aattggctgt ttgtatgaaa caatggccag tacttctaaa 2163961 gatgcttgag aaaggccctt tgacggcact tcaatcagtt ttttcaagta aggcgcaaag 2164021 tcttttttgg tagagagcat gtacgtatct gcatactcaa taagttcaat ccctcgtgta 2164081 tctccgcggt attcgtccgc cacatccgcc atgatcgtgt tcagttcagg ctcttcgatt 2164141 tcaagcactg ttaacagctg cttttttgta agcccttcat cgcctgccgc ataaagaagg 2164201 gcttccacaa tagctttcca attcacgata tcaagcccca tgaatggatt cactccccgt 2164261 aatgtaaata tctgaaaaat tgtgctcctg ttcaatgagg accagctgat ttttcatcag 2164321 ctcaagaaca gctagaaagg tcactactaa atgttctttt tgctcatatg gaaacagatc 2164381 cataaagtta attctcgttc ctctagattt caagctgtgc acgatttcgt tcattctggc 2164441 ttcgattggt atgtcctgtc ttgtaattgt tgtttccatc ggcctgttta tttttttgcg 2164501 tttcagcact ttttgaaaag ctccgatcat atcatagacc gtgacagaga gcttttgctc 2164561 agactgtttt acttcttttg catattcact caaatcactc ggcggtttcg tgaacgattt 2164621 ttgtctttct tcttcccgtt cttttaaatc cttcgccgca tctttatatt ttcggtactc 2164681 aatcagcttt tcaatcagtt cctcccgcgg atcttcttct tcaagtaatt catcttcaaa 2164741 aagctcctcc tcttgcttcg ggagcagcat tctgctttta atgctgagca gcgtggcagc 2164801 cataaccaaa tactcgctgg caatgtcgag ctcaagcacg cgcatcgtat gtacatataa 2164861 taaatattgt tcagtgatct tcgccacagg tatatcatat atgtcaattt caagacgatt 2164921 gattaaatga agcagcaggt ccaatgggcc ctcaaacgta tcaattttca cttgatattc 2164981 ttccatcatc tcaccatttt caagtatcac tctcattgcc ggaaaaactg gctaccctat 2165041 agtataagcc accaaaaagc tctcgtccaa tactatttca tatcctgttt tgaaggagtt 2165101 tgtacagaat attcaaaaca caagaggtgt ttgctcggag cgcagaagcg ggagaaaaag 2165161 cctttgcttc tggttttcct ttctaagaag cactagaggc cgggcgttct tttttccttt 2165221 tatcccttct atggtacact aaaagcacat taaaggagga agcaccttgt atccgaaagc 2165281 ttatatagat tatctcgttg agtttcatgc gacacgggat tattttgaat gccatgaaat 2165341 attagaagaa tattggaagg aagatccgcc aaagaaacga aaacgctatt gggtgggctt 2165401 tattcagctt gcagtggctt tatatcatca cagaaggcag aatacagccg gggcaaaaag 2165461 actgatggcg aacagcatcc ggattcttca agcagaacac cgggcagtcg aagacttagg 2165521 gcttgatcat ggccgtttgc tcgaacttat gcaatcggtt tacgaacaaa tcgaaaccgt 2165581 ctctgcctat aaaagcatta tactgccaat caaagatgag aaactggagg aagcatgcag 2165641 gatcgaatgc aggaaaaaaa agtatacatg ggggcagccc agtgcactca gcaacatatt 2165701 tcttatcgac aaacaccgtt tgcgggatcg gactgacgtc atccgtgaac gtgaaaaaga 2165761 aatagaacgc agaaaaaaaa gcagagactg atcacagcct ctgcttaatt attgtatgaa 2165821 atgtcttgat cctgctgacc ttgacaacgt tcgaaaaagc tctgcgttaa ttcatttgga 2165881 accagtactt gcgttttgaa taaatgcttt aaagcatcca tcatctgttt tccgattcct 2165941 tgatggcgat gagaaggatt cacactgata tgccggatct caacctcaga atcctttttt 2166001 tcgactccga ttgctccgac gatatcctcg tcctctttcc aaagaaagag ctggcggtct 2166061 gtatccgttt cgtagtcctt aattgtctgc tgaagctgct taaggtcttt ttcattcggc 2166121 ataaacgaaa gaagccccat cgcaatcttt tcaaacgatt ttttataacg aattaacata 2166181 aaaacccctc tatatccaaa atgtccagtc tgctattaac ggatacgaat aggtgatccg 2166241 ttttctcaca ttatatcatt ttcgccatat ttttaaactg ttttcagcaa attattcaaa 2166301 tgagcggttt aaatttgcca tttcaatggc agaaacagca caatctacac ctttgttgcc 2166361 cgcttttgtg ccggcacgct cgatagcctg ttcgatgttt tcagttgtta caattccaaa 2166421 gatgacaggt acaccagtag tgtttgctgc ttgcgcgatg ccttttgcag cttcattgca 2166481 gacataatcg taatgtgtcg ttgcgcctct gatgacagtg cccaatgtga taatagcatc 2166541 atattttttt gtttccgcca tttttttcgc agcaaacggt atttcaaatg cgcctggaac 2166601 ccaagccaca tcaatgtcat ttgtgtctac gccatgtctg agcagcgcat cttctgctcc 2166661 gctcagcagc ttgctcgtaa taaaatcatt aaatcttcct actacgattc cgattttaag 2166721 acctgtacca actaaatttc cttgtatgat attcatatga ttcccatcct tttttgtgat 2166781 atttgtgatt agaaatgaag taaatgacct agcttgttca ttttggtttg caaatatttt 2166841 ttattgtgtt ctttcgcctc catttgaagc ggcactcttt ctgaaatact gagtccgtag 2166901 ccttcaaggc ctgcgatttt tcgcggatta ttcgtcaaaa gcttcatatt ccggacaccg 2166961 aggtcgcgta aaatttgtgc tccgatgcca tagttgcgaa gatccggcaa gaatccaagc 2167021 gcctcattgg cttctacggt gtcatagcct tgttcctgaa gcttataagc ttttaattta 2167081 ttgattaaac cgatgcctcg tccttcttgg cgcaagtaca ggagcactcc acggccttct 2167141 gcggcaattt ggttcagcgc ggcgtgcagc tgcggtccgc aatcacagcg atgagagcca 2167201 aacacgtcac ctgtgagaca ttctgaatgc acccggacca ataccggttc ttctccgaac 2167261 ggcacatctc ccatcacaaa tgcgacatgc tcttttccat ctacctcatt tgtgtatcca 2167321 taaaccttaa atgtcccaaa atcagtaggc agcgtaatgt caacttcacg ctcgacaagt 2167381 gttgtcagat tgtaacggta ttgaatcaaa tccttaatgg tgatcatttt taattgatgc 2167441 tttttcgcaa tttcaatgag ctcaggcact ctcgccatcg ttccgtcttc attcataatt 2167501 tcacaaatga cgccggctcc tggagatccg caagcttcag caagatcaac agcagcttct 2167561 gtatggcccg ctcttttcag gacacctcct tttttcgcaa tcagtggaaa aatgtgcccc 2167621 ggacgctgaa aatcagatgg cacggatttg ctgtccagca atgcttgaac ggtaaaagat 2167681 ctttcttgag cgctgatacc tgtcttcgtt tcacgatggt ctatgcttac ggtaaatgca 2167741 gtgtggtgag agtctgtatt atgctcaacc atagggtgaa gatcaagcct gtctgcgatt 2167801 tcctcactga gcggcgtgca gatcagtcct ctcccatgtg tcgccataaa gttaatgact 2167861 tccggcgttg catgctcggc aagagccaca aagtctcctt cattttctct gtcttcatca 2167921 tctacaacga tgatgacttc gccttttttt aaagcgtcca gtgcttcttc tatcggatga 2167981 aacatgcaaa tcttcctctc taaaagccgt tttcgcttaa gaaggctttt gtaatggttt 2168041 gttgggtctt attttcattg gctttatgca aaaatcgata catatatttt ccgatcatat 2168101 cgcattcgat attcacttta gagccgatcg ttttttctga aaagatcgtt tcgctgatcg 2168161 tatgcggtat taaggagatc gtcactgtgt cttctgtcag gccgaatatg gttaagctca 2168221 cgccatccac agtaattgat ccctttaaaa ccaatgtttt tgttaatgac gggtccattt 2168281 ttaaatcata gtaaactgcg ttgcttttct cttcaattcg tgtgatttcc gcagttccgt 2168341 cgacatggcc tgagacgaaa tggcctccga aacggccgtt tgccgccatc gctctttcca 2168401 gatttacttt gcttcctttt gttaaatcat tcagtgacgt agctttgact gtttcaggca 2168461 taacatccac tgtgaattga ttttttgtaa aatcagtgac agtcagacaa atgccgttca 2168521 ctgcaatgct gtcgccaaga tgaacatcct ctaaaatctt tgagcattta atagttaagg 2168581 ccattgcatg ccctgctttt ttcatggatt cgattgtgcc tgtttcttcg ataattcctg 2168641 taaacatggt caccatccta ttcctttgtc ggttttgccg tcagtttgat atcacggccg 2168701 atttgggtta tatcagtgaa ttgtaataag gggacatctt tcattgattg aaaaccttca 2168761 ccggagatta agctgggagc atgcgttcct ccgattagtt taggggcaaa atagaagatg 2168821 atttcttgaa aacagccttc tttgacaaag cttccgtgaa cagctgaacc gccttccaca 2168881 tacaccgaca tgatgccttc ttccgctagg atcttcaaaa catcaggaat ttgaatgcgc 2168941 tcggtttcaa gtgtaaatat gttcactccg aaagctgaaa gccgtttttt cttttcctcg 2169001 tctgcgcgtg ccgtcgtaaa aatccatgtc ggcgctattt gatcgcaaat cactttagcg 2169061 tcctcaggaa tcgagagtac ggtatcaagt atgacccgaa ccggctgttt tgttacattc 2169121 ggcagtctgc aggttaagct cggattgtcg gctttcactg tgccaactcc gactaaaatg 2169181 ctttggtgtg ttttcctgta ttgctgagca tcctgtcttg cagcctctga cgtgatccat 2169241 ttgctgtcac ccgtgctggt agctatcttg ccgtcaaggc tggcagccgc ttttagcgtg 2169301 acgtacggaa ggcctgtcct cataaagtgc agaaattttt cattcagcct ctccgcctgg 2169361 tctgccagga tgccttccct tacctcaatg ccagcttctt tcatcatgct gatccctctt 2169421 ccagccacaa gcggattagg atctctcatc gccacgaaca ctcttttgat accagagttg 2169481 ataatcaatt ctgcacatgg cggtgttttt ccgtaatggc tgcacggttc gagtgtaacg 2169541 taaatgtcgg caccctctgc atgtgctcca gccatatgga tggcatgaac ttctgcatga 2169601 gcttcaccat attttaaatg ggcgcccatt ccgacaattt gtccgtcctt tacgacaaca 2169661 gcgccgacga gcggattgga ttcggtctgt ccttcgccct gcttcgcaag atctaaggcc 2169721 agcttcatat aatactcttc catttgtttc cctcccctct tttgttattt accgtcaaaa 2169781 aagccccgaa tttataaaaa attcggggct ttaggtattt tacgcaatag gaaataacac 2169841 tatgcatttt taaacatttt gcatagcggc tcatcatcct tctcccatcc agactttcac 2169901 tgtcggcttc agcttaaact gaatccaccg cgtgcttatg cacacgggtc acgggctcta 2169961 aagcaaatgt gctttactac cgccggtcgg gatttccacc ctgccccgaa ggatacaatc 2170021 tttattcatt tgtccttatt ggttattata gcgatccttt ttaaagtacg caatgaaata 2170081 aacttacaat ttgagaaaaa caaaacatca cccttcgatc cgaaaggtga tgttttttaa 2170141 tcattcactt ttgcaacctt gattaatccg tcgatccgct ttgatttgct gaagtaagcc 2170201 ttaatcttgt caccttcttt tatatcagat aaatcctgat ttaatttttt tccgttgaag 2170261 atgattttcg ttccgttttc tgctactcca tgatactctg agccgtcaat tttcgtcact 2170321 ttatattcct ggatggtgta ttcctcttct tccgaggaca aggtttgtcc aattgctgtc 2170381 ggaacatcct tcagctcaat atcatttatg tacatataac cgcctgcaag taaaagcaaa 2170441 agcactaaca gaatggtaat cttggttttt attcttccca tttctaaacc tccagccaat 2170501 atgaatctat tcattcatat gagttattcc tttttttcat gaataaaaaa ccgtaaattc 2170561 tcgtaaatta ttaatataac gatgcataac gggaatatgt ttcacatttc tgcaaaaatt 2170621 tcttttctat agatatacga atttatgttc tgtttttagg ggatgaccgt aaaaaagata 2170681 taaaaaaagc agccccaatg ggaagctgct tgatcctaat ttgttttgcg catttcgtta 2170741 aacgggtaga aaacaaactt tgacgtaccc gcaatttgtt ttttcgtgaa gaggccaagg 2170801 ccgttacggc tgtccatgga attgcgacga ttgtcaccca tcacaaaata cttgttatca 2170861 ggcactttaa ccgggccgaa atcatcggtc aaatggtcaa aaccgtcctg tttcgctctc 2170921 tttttattag ccgccaaata aggttcgtcc acctttttcc cgttgatata gagctggtca 2170981 tttttcatct caaccgtatc gccgggaagg ccgataatac gtttgacata gtgaacatca 2171041 tctccgttta acacgacgat gtctcctcta tcaaactcgc cgatgtattt gactgtcata 2171101 ttaacaaaaa ccctttcacg gttgtgaagt gtaggataca tagagtcacc atcaacgaca 2171161 tacggcgcaa aaataaagtt gcggatgagc aaagcaagaa cgacagcaat cacaattgct 2171221 tttgcccatt ctaatattga ctttttcttc gaaacatttt ctgatttcaa ctgatttcct 2171281 ccaataaaca acggtcttca atttatgtta tcacgaatcg aaaaaaaatc ccattaggac 2171341 cattgaagtg attttacaaa ctgttaatct tcatcttcta cccacatcat gcctattttt 2171401 tcttgtcgat cataactagg cctgaaaata ttgaaagaaa tgaatcgcat aattcagaag 2171461 cgatggactc agaagaaaga gagttctcat atgcaaaatc tttagatcgt atataaagca 2171521 tgaggttacg ggcagtttgt tcatttactg cattccattg atctcccagt ccatgatacc 2171581 catggcactt gacaaaacaa ttaacgtcat gaaggttact ggaatgtttg cggcaaccta 2171641 tttcacaggt gataaccgca ccccgttttt tgctttcata atatgtttaa aatcattcaa 2171701 gctcgaaaac atggatcagc ctccaaaaaa taaatccaat atattcccgg cagttgaaga 2171761 ctctttatta taaaactctg aatatccgca gttcttacag taaaccacta gaaatcggtt 2171821 atgctgcacg tcaaacagct ttgataatcc cgtgccggtt gtagctattt ctttttgtcc 2171881 ggcttcagta ctaccgcatt ttatacagcc tttgttgttc atatcgcgat ctccttttca 2171941 ttacatcacg tttgtttgat ttattttact acaaaatatc aatcccaatg acccgtacta 2172001 ctttaaagtt tacttaattt tgattacata ctaattgggt tcgtttctca gcttggtaaa 2172061 tcttctggag aaacggaaaa gctccatgac caaaacattc aaactcagcc aaacaccgcc 2172121 gaaggcgtaa cccgcagcaa catcactcgg atactgctca taaagtacac acggctcagc 2172181 ccgatgagga ataaaacgat aataaacaaa aaaatgcaac agtttgcaga cgcgtcttgt 2172241 gagaatgacg aacaaaaaga taagcacaaa aaccaaaaat gacaaatgcc gttaaagtct 2172301 gttcgctcgg gaatggatat aatacatgac tttccaaagg agcgtgaaca ggatgaaggg 2172361 aatgaaagag ccgtctgatt ccctcttcat aaagctcccc accaatgact aggaaaaata 2172421 agaaagagag ttcgattttc cgatcttgcc ctctgaatac cgtccaaaaa aaagttagaa 2172481 caataacggc taacagaaca cctctcgacg caaaagcttt ctgaattgca gctgggccca 2172541 gtctataccc gatccaatac gacatgctca ctcccacagc tccccaatcc ggccgctaac 2172601 atgcttagca cccagtttaa cttttcttga aacacgagaa caccggcaaa ctctcccggt 2172661 ccaagtaaag ctagaagctc taacatcaag acaataaaca agacggcata tccgtactgt 2172721 tcgagcaacc ccgtcaaaac ttgcatgtga ttctccttaa acttttttgt tcttttatca 2172781 ttcccaatcc actttttgta taatcagcac aattttatct tcagtcgtcc aacaacattg 2172841 tctatggcgg gatcttctct catacattct tttttgacat aggaggagca atagcatgaa 2172901 atgggaggaa acaaaagata cgcagggagt ttgccaaaat tttgggcagt tcgttctgcc 2172961 accgagtcag gtgtttgttt gcccacctca tcccttgtca attccccatt tttcccgttt 2173021 gaggttcgaa atggtaaagt atttcactta gtttcttaca tgaagaggta aattctttgc 2173081 tcaccgaact aggatagcgg cgtatggcga tttctacatt gcataaccac tggttattta 2173141 gtgagccgtg agcaatgtat atgcactttg agtcagcaca ggatgatcct attacattcg 2173201 ccagaaaagc agctgccgca ttcagagtag ttaaaagaat agacagatat ctgggcttcc 2173261 ggaagcttta aaggaggctc ttttttcgag catttttata aatcaataaa aacaggcatc 2173321 tcctaaatat ttttgccgat aagtttacgc taatcaactc tagcactaat acatataaaa 2173381 aatagaatga tatgaaagga gacttgatag tatgattgat tatcctatta atataaacaa 2173441 cgtttccggg aacagtgtaa ttaacgtagg cggcgctttt atgatcaggc ctttaacttt 2173501 gtccaaatct gtgtttggct ccggaggttt aaacacagga attgtctttg aaaataactt 2173561 tgtaagcaaa gctaaaatga ttaatcatca atttactgat caaaacgtca ccaaaacttt 2173621 ttaatgtatt caatacacgg gggtcactaa ctaaacacct ggttttgcca accgccatca 2173681 gcattcggcg gttttttatt gaacattttt ggccaataaa aaaagcttcc tctctaagag 2173741 gaagcctttt gcctgccgat tagccttcta cacgaacttc tttcatgaca tcgccattag 2173801 acatgttttt cgcgaattct aatccgcttg ttactttacc aaatacagtg tgaacaccgt 2173861 tcaaatgagg ctgtggctca tgaacgatga aaaattggct gccgccagtg tcttttccgg 2173921 catgtgccat agaaagtgcg cccgcctcat gtgtatgcgg gttgccttct gtttcacatt 2173981 tgattgtgta tcccggaccg cctgtaccag ttccgtgcgg gcatccgcct tggctgacga 2174041 agccagggat cactcggtgg aatgtaagcc cgtcataaaa gccttcgttc gcaagctttt 2174101 caaagtttgc aacagttcca ggtgcagctt caggataaag ttcaaattca attttgttcc 2174161 cgtcttctaa taaaaagtaa cctgttttca attgtatgcc tactttcttt attttaattt 2174221 tcaaaggaga ttatgtatag gttatagcct gtctctcctt gtcgcggcta ttataccaca 2174281 cctttcgggg gaaaacgaat ctcccgagct ttactaaaaa ataaaaatga aacctgaatc 2174341 tctttatctc cgtctaacct aacggaactg tatttttcat gattcaggtc ctcacaaagc 2174401 agcactatcc agctgcttgt gaaattgaag gaggtcaaac tgctttgaag aaaatttgga 2174461 ttggaatgct ggcagcggcc gttttgctgc tgatggttcc gaaggtcagt ctcgcggatg 2174521 ccgcagttgg agatgtcatt gtaacactgg gtgctgattt gtcagaatct gacaaacaaa 2174581 aagtgcttga tgaaatgaat gtccctgata atgccacaac ggtaaccgtg accaataagg 2174641 aagaacatga atatttagga aaatatatat cgaacgcgca aatcggatcg agagcgattt 2174701 cttcatcgtc aatcaccatt gccaaaaaag gctccggatt gaatgttgag acccataata 2174761 tcagcggcat cacagatgaa atgtacctga atgcactgat gacagccggt gttaaagatg 2174821 cgaaggtgta tgttacagca ccgtttgaag tatccgggac tgccgcttta actggattga 2174881 ttaaggcgta tgaagtttct tctgacgaag cgatctcgga ggatgttaag caggtcgcca 2174941 accaagagct tgtcacgaca tcagagcttg gagacaaaat cggtaacgaa aatgcggcag 2175001 ccctgattgc aaaaatcaaa gaagagtttg ctaaaaacgg ggtgcctgat aataaagctg 2175061 acatcgaaaa acaagtggat gacgcagctt ctgatttaaa cgtcacactt acagacagcc 2175121 aaaagaatca gcttgtctcc ctattcaata agatgaaaaa cgctgacatt gactggggac 2175181 aggtcagtga ccagctagat aaagcgaaag ataagattac gaaattcata gaatcagatg 2175241 aaggcaaaaa cttcatccag aaagtcattg atttcttcgt atctatctgg aatgcgattg 2175301 tatctatatt caaataagaa aagcgccgaa aaatcggcgc tttcttttat tgctttacac 2175361 ccgttttaaa tggcagatca agttttacaa tatcttcgta tgtttctcgc ttcacgacta 2175421 aatgagcctc accgttttcg acaaatacaa cggcgggtct cggaatacgg ttataattgt 2175481 tggccatgct gtatccataa gcgcctgtac aaaaaacggc aagaagatcg ccttctttta 2175541 cttccggcag gtcaatatcc caaatcagca tatctccgct ttcacagcac tttccggcaa 2175601 ttgataccgt tttgtcatgc gcttctccga tcctgttggc tgccgcagct tcatatttag 2175661 cttggtaaag cgcaggacga atattgtcgt tcatgcctcc gtctacagcc acatattggc 2175721 ggacacccgg cacttctttt tgagagccaa ccgtataaag agttgtgcct gcgtctccca 2175781 cgagagaacg gcccggttcg atccaaattt ccggaatgtc aaaaccgtaa cgggaagcat 2175841 tttctttcac agcttcgata attttttcaa cgtattcagt ggcatgaagc ggttcatcat 2175901 cttccgtata acgaatgccg aaacctcctc caagattcag caccttggat acaaatgaat 2175961 atgaatctct ccattcgtct agttttttga agattttttc cgctgctaac acaaaaccgg 2176021 ccgtatcaaa gatttgcgag ccgatatggc aatggacacc cagcagctga atgtgttccg 2176081 attgtaatac ttgttcaatg gcccgttcag tttgtccgtt atgaagatcg aaaccaaact 2176141 ttgaatcttc ctggcccgtt gtaatgtagt catgcgtatg cgcttctact ccgggcgtga 2176201 tccgaagaag aacatcgatg gagtgacccg tttctttaca taggtcttca agaagcgcga 2176261 tttcatagaa attatccacc acaatgcagc cgatgcggtg ctcaagcgcc atccgcagtt 2176321 cttccctgct cttattgttt ccatgaaagt ggatgcgttc tgccggaaag cctgctgcaa 2176381 cagccgtata tagctctcct ccggatacga catctaaaga aagtccctct tcctcagcga 2176441 gctgaatcat tgcgactgat gagaatgctt tgctcgcata tgccacctgt gctttcagcc 2176501 ctgcagaaat aaacgcctgc ttaaagcttt tagcacgctc acgtattaaa gccacatcat 2176561 atacgtaaag aggtgtacca tatttctccg ctaaatagag agcatccaca cctccgattt 2176621 ctaaatgacc atgttgattt tgtctgcttg tgccgtgtaa gaacaatgtc attccctctt 2176681 tctccgctta tggatgaaag gacagtttta tggactgtcc cttcataatt aagacataca 2176741 ttatcatact cttcagtcag tttcaatgcg attatgaatt ggtaggctgc cttaagcgat 2176801 ttttggggtg aacgatgctg ggtcttactt ttgcgccagg tttcgctgtg cggacaagaa 2176861 cctgccacag cgcctttccg ttaaagggaa tcagcggcca taagtacggt gtctgaaggg 2176921 atttgatgct tgccatggca ataattagca ctgtaaatcc gatgacgagc ccttttatat 2176981 gaaataaagc aacgagtatc atgaggacaa gacggctcat tttgtttgcc aagcttaatt 2177041 cataactagg cgtcgtaaag gttccaatcg ccgcaagtga gacgtacaga atcacctcag 2177101 gagaaaaaag gccgacctca atcgcaatct gcccgatcag aacagcggca attaaaccca 2177161 ttgctgtcga taaagccgtc ggtgtgtgaa tggcagccat tctgagaaac tcgattccta 2177221 agtcagctaa aaatatctgc aggatgatcg ggatatgcgt atctttattt aaaccgataa 2177281 atttcatgtt gtccgggagc agatcaggct gaagcacaaa gagaaaccag atcggaagaa 2177341 ataaagtaga agcaagaata ccgaaaaatc ttacccatct taaaaaggtc ccgactgaag 2177401 gcgcctgcct atattcttca gcatgctgca catggtgaaa taaagtcgtc ggggtaatga 2177461 tcacactcgg cgatgtgtcc actataatga taacatggcc ttctagaaca tgatttgcgg 2177521 ccacatccgg tctttctgta tagcgcacga gcggaaaagg attatagctt tgattaacaa 2177581 tgaattcctc gacagttttg tctgccattg ttaatccatc gacatcaatg gatgcaattt 2177641 ctttttctac gatctcaacc agatccggat cagctatatc ttctatataa caaatgctta 2177701 aatccgtctt tgaccgctca ccaactttag tcatcttgac tcgaaggcgt tcgtctctga 2177761 tccgccttct gagaagggcc gtattgacga cgatattttc aacaaatccg tctctggctc 2177821 ccctgaccac cttttccgta tcaggttctt ccgggtttct gcccggatag cttctgacat 2177881 caattataaa tgcgaagcct gcaccttcaa caatgacagc gacgagcccg gacagcactt 2177941 ggtcggtggt ttcatccaag gtttttactt tttcgacctg ggcgttaagc agcctgtttt 2178001 cgacgatgtc gaccagctca tcagggtctt ctttccgatt gttaatggca acaagctctc 2178061 tcattaaatg aataatatag gctgtatcgc ataatccatt tagatagtaa agctggatct 2178121 ctttatctaa aatcgtgagc ttgcgaacac ctacatcata gctcgtcccc atcccaacac 2178181 ggtttttgaa atactcttca tttttagctg gattccgata aacccgaatt ttctcttcct 2178241 tgtggtccgg catgataccc gctcctttct aaaataaact cgaccgcttt catggtgatt 2178301 ggcgaccctt ttgagatatc gtcttttctg cccattttgc cgatatcccc gataccgaca 2178361 ataagcggga gatcaagttt atcaaggcaa tagactgtat ctccactcat tctgtggtca 2178421 tcaaattccc tttccccgac tttatcgacg ccgtattcag ttatttctcc attgcggtca 2178481 atgcttacat cgaccctggt ccattcagcc tgatgtgttt ttgacgcgac cgcaatcaca 2178541 ccgagcactt caatagacgg atgggttgcg acataggtta gagcggcttc tcccgggccc 2178601 tctccttgaa ggccggagtc gtcaaacatg acaaatacag gatcatacgg tgctgaggcg 2178661 atcagcttga caagctcggc gccgctgcgg gtggaaggat tcccttttga ttgtgaaata 2178721 catcggcctc ccactttgct tgcggcgtat tcaattgttt tagcggcata aacatccccg 2178781 tctgttacca gtatgacctt gcgttttgtc gtcatgtcgg cattatcctt tcggtttgaa 2178841 aataacagct acgataaagg cgaaaagaat agcggctgag ataccggccg aggtcagctc 2178901 aaaaatcccc atgccgattc cgataaatcc gtgtatatgc gcctgatgca tggcgccgtg 2178961 cagaagactg tgaccgaagc tgacgatcgg aacggtggcg cctcctccgg caaattcaat 2179021 aaatttatcg taaatgccga aaccatctaa tattgcaccg attacaacaa atgatgtcat 2179081 gacatgagct ggcgtcaatt taaaaatatc caagagcagc tggccgacga tacagatggc 2179141 cccgccgcag acaaaagcca aaaggtagtc catattaaga tgcacctcct gcacgctcaa 2179201 atacaacccc gtgggcgata gtcgggatgg tttctttttg ctggatcatc gtcgggctta 2179261 atagcgcccc ggtcgccacg acaaatacac ggtttagttt tccttctctc agctgcttaa 2179321 aaatatgaga gtaggtgaca accgctgaac aagcacagcc gctccccccg gcaaagacct 2179381 gctgatccgg agtgtaaatc agaagcccgc aatcatcatg ctttgtgccg actggatatc 2179441 catcttcttt taaaatgtct tttacgattg gagaaccgac gcctgacagg tcacctgtca 2179501 ggattagatc atagtcatcc gctgtccggt tgagatcttt aaagtgctgc ttaatcgtat 2179561 cagctgcagc cggagccata gccgatccca tatcaaaagg atctgtaatt cctaaatcag 2179621 aaaccttccc gacagtcgca cttgtgattt ggatatcacc cggtgtctga ctgatgacaa 2179681 ctgcaccgct tccggttaca gtggaggtag cagtgtccgg tttttggcct ccgtattctg 2179741 tcggatagcg aaactgtctt tccgcagttg cattgtgact gctggtggca gcgagtgccc 2179801 ttttggcaaa ccctccatca actaaggctg atgcgacagc cactgtttcc attgatgttg 2179861 aacaggcgcc aaacatacaa agaaatggga ttttcaagtg tcttgccaca tagttagccg 2179921 tcacgttttg gttcagcaag tcgcctgcca gcaataggtc aatatcatct tttgtcagat 2179981 tgtttttttg aagtgcaaca ttaacagcgt cttccatcag ctgccgttcc gccatttccc 2180041 agcttttttg attacaatgc atttcgtcat aggttttatc aaataaagag ccaagcggtc 2180101 cgtctttttc ctttggtcct gctgccgttc ccgctgagtt gacaaatatg ggatgttcaa 2180161 atacccaggt ttgctttcct gttaatttca ttttcttctc ctcctatgac atcagtttct 2180221 caaaagcaaa ccgaatcatt ccaacgatgt atgcagctac aactccgaaa acaataacat 2180281 ttcctgccag tttaaacata tttgtcgcta ctccaagcac taatccttcg cttttatatt 2180341 caagagccgc acttgccata ctgttggcaa aacccgtgac aggtacggct gaacctgcgc 2180401 ctgcgaattg tccgattctg tcatagattc caaaccctgt aagcagggca gaaattaata 2180461 tcagcgttgc agctgttgga ttccccgcag ttttttcatt gaaatcaaaa aaatggatat 2180521 aaaaattttg cagaccttgc ccgattgcac aaatcagtcc gcccactaaa aaggctttta 2180581 cacagttcca gacgtaaggc ggcttaggct gatatgtttt cacttttgat ttgtaatttt 2180641 cttttatgtt tgtcatcttg aaacctcctt atgaatggtc aataaagtac agccagtgaa 2180701 ataaagatcc cgcgattttc ccaatcacga tggccattaa cagaataatg attttacttc 2180761 tgagcccgat tcgtttcgcc aaaatcggca ggacatttaa aacctctgta agagcagccg 2180821 ctagcatccc gacgaacaaa cctgccagaa gcccgaccgg cacagctatc cattttgtta 2180881 gataaagatg attcatatga agcgtctccc atcccccgca aaccgcgcca agaataacag 2180941 ccgcttcata agcctgaaca aatctcattg ttttggtgag ctgcatcagc cgcggaatga 2181001 ttcccattac ggttaaaaaa gcaacgaaac ccgcccccac cgttatgcct ccgccgagcc 2181061 cgacaaaaat gatgaacaat acactaacga tcatgcagat cctttatggt ttcttgattc 2181121 tcatgcatgg ccacatattg atcgagatca agctgatagt taaacatctc aacctccagc 2181181 gggctgggct cttcatttag gcgcttttta aatatgtggt taaaaaacac gatcatcccc 2181241 agtcccaaac cgatgctgta tgggatttga agcaaatatg gatagtcatt cctctctccg 2181301 gttatgattt catatagtgc gatatgaaca tctctcatgc ttacatcctc atgaaagttc 2181361 atgatggcaa gacacgatcc aataaacaga agcagccaga caccgataaa tagaaccgtt 2181421 gataaatttc gctttcgata ctgaatttca acaatggttt ctgctccgcc tacggtttga 2181481 acatcaattg tcgggtcttg taaatgaatg gctctgagga cttgtatgat atccagaatt 2181541 acgatatttt tatctttttc gctcacctga taaagcggca tagccgaaag tttctttttc 2181601 agctgaagct gcccttctat ttgcgcggca tctccaacgg taataatatc ccctggatgt 2181661 gccagcactc ggtggcgaag ccggataaat attcgtcgtt ccatcattga tcaccatctt 2181721 tcggtggtta tatatgtagt atgtggttcg attttgttct cattcatccg ctcgaaaaga 2181781 ccataaatta ccacgctttt gcacaaaaaa gctagcctgc actgcagact agccatccgt 2181841 atgatccatt tgaaccttga tctgttttaa tattttcttt tcaagcctgg aaacctgcac 2181901 ctgagagatc ccgagccgct cagccacctc ggactgtgtc tggtctttat aatatctgag 2181961 atagacgatt agtttttccc tttcctccaa atcgctgatc gcttctttca gcgcaatttt 2182021 gtcaaaccat ttttcttctg agttgtcagc gatttgatca agcagggtaa tcggatctcc 2182081 gtcattttca taaacggttt cgtgaatcga agatggagcc cttaccgcct cttgggccag 2182141 tacaacatcc tcagcttcaa tctccaaatg gtcagcgatc tcctgcaccg tcggcactct 2182201 gcccagtgtt ttcgaaagct catccttcgc gcgccggatt ttgtttccaa gctcttttaa 2182261 tgaccgtgat acctttacgg ttccgtcatc acggataaat cgttggattt ctccgataat 2182321 catcggcact gcatacgttg aaaaacgcac atcataggtt aaatcaaatt tgtcaacaga 2182381 ttttaacagc ccgatgcagc cgatctggaa gagatcgtca ggctcatatc ctctgtttaa 2182441 aaaccgctgt acgacagacc aaacaagacg catgtttttt tctatgagga ggtctcttgc 2182501 ctgctggtcg ccattttggc tttgtttgat taattccttt acttcatgat ccttcagctg 2182561 agcgtttttg ccgtttttct taacctccac atccataaca aatctcctta attacaaagc 2182621 gctttgcttt ttgataagtg ctttgttaag cgaatcgttg ttcccatttc aggcgatgaa 2182681 tcgatactga catcatccat gaaattttcc ataatggtaa agcccattcc agagcgctca 2182741 agctcaggct tagtcgtaaa tagaggctga cgggcttctt caagatctgt aatgcctaag 2182801 ccttcatcac gaatagtcat atatacgaca tgatcttcca gcgtcactga aatgtaaact 2182861 ttcccttcac agttctcttc atatccatgg ataatcgcat tcgtgacagc ctctgacacg 2182921 actgttttga tttcagtcag ttcatccatt gtcgggtcca gctgagctat aaatgaagca 2182981 actgtcacac gggcgaacga ttcattctga ctgagggcag aaaactcaag gtgcatttca 2183041 tttttcatga tgccaccccc agtgtcagga gtgcctgctg ttcagattgt tcaaatcgga 2183101 taattttaaa cagacccgac atatcaaaca atcgcttcac cgcaggagag atagcgcaaa 2183161 caaccatttc tccgccaatt tgcttaattt gcttgtatct tcctaaaata acgccaagcc 2183221 ccgagctgtc cataaaggaa aggtcctcca agttcagcac gatatggcga atatcatcct 2183281 tctccaatga ttgagtcact ttttgcttca gggtttcagc cgtatggtga tcgagttcgc 2183341 ctgttaatcg aatacaaagc acagattctt tgacattcat gtcaattcca aggctcatgc 2183401 tcattcctcc ttgatatgat cggataatga gtgtttcgat ttcgacggaa tgaattcctt 2183461 caccgtgaca aaactagtgg tcattcggca taattactta aattttgtcc agtctcccat 2183521 cgtccgcttt aagaatgtga taaacccggc tttcttcata tcttcttttg cagcaacagg 2183581 actttcagcg agtacttctc catccttttt cagaacaaga gtgccaagct cttggccttt 2183641 ttgaatcgga gcactaatat tgtccttcat cttgatttct tttttcacat cgttcatatc 2183701 ctcgcctttt ttcgtcaata ttgaaatcgg ctcagatgta gtgagttcga taaatttttg 2183761 tttccctttt ttgaccttta cttttgctac tgtttgattt cgtttatata aaggatgcgt 2183821 ttcatattgg ctaaaggcga agtcaagcat ttttgtcact tgcgcgtttc tttctttagg 2183881 cgtgctcgct ccgaatacaa ccgctatggc ccgcatgttt ccttttttag ccgaagcagt 2183941 cagacaatat ttcgcttcgc ctgtatagcc tgtttttacg ccgtctacac caggataaaa 2184001 tttgataagg cgatttgtat ttacaagcca aaacttttta tctgtatttt cacgcagata 2184061 atcttcatac gtgccggtaa acttcgtaat tgattcgtat ttcaataatt ccttagccat 2184121 gattgccatg tcataagcag agctgtagtg tccttcctcg gtcagtcctg ttgggttttt 2184181 aaaggatgta tttttcaatc ccagctcttt tgctttttta ttcattttct tcacaaattc 2184241 ttcttcagag ccggaaataa attcagccat ggcgacggaa gcgtcatttc ccgaagcgat 2184301 tgcgatgcct ttcagcattt ctttgacagt catttcttcg ccgggctcaa ggaatatctg 2184361 tgagccgccc attgacgccg catgctcgct tgtacggacc ttatcactca ttttgatttt 2184421 gcctttatct aaagcttcca taatcaaaag catcgtcata attttcgtca tgcttgcagg 2184481 cgccagtctc tcattgctgt tcttgttgta aagcactttt cccgtgtcac gttctatcag 2184541 caccgcagac ttcgcttcat gagcaagctc cgatgtacgt tttccgtctt gttttgcaaa 2184601 tgcagacggt gcaaatgtaa gcagcattat accaatcaac aaagtggata aaagacgttt 2184661 catctcaaaa gccctccatt tcataatcct ttttattttt tccaagcgtg atggttttat 2184721 acgccactga tggaaaatgt ttcgaatttt gggcataaaa aaagacagct gtgtgatatc 2184781 agacacagct gtcttttggt cctgcattga ttcatattta ttcgtactga gcgacgatcg 2184841 ctttaacaag ctttaagaat ccagctttta ctttttcggt cacttccata acttcatcgt 2184901 gacttaaagg ctgatccaga attccggctg ccgcgttaga gatgcaggaa atgccaagaa 2184961 cccgcattcc cgcatgattc gctacaatga cttccggaac agtagacatg ccgactgcat 2185021 cagagcccat cgttcttaag aaacggactt ctgccggtgt ttcgtaagaa ggtcctgtca 2185081 cagcagtgta cacgcctttt tgaattggga tattaaggtc tttcgcaatc ttttcagcca 2185141 ggctggacag atctttgtca taggctgaag acatatctgg aaatctggcg ccgaaatctg 2185201 cttcgtttgg cccgattaac gggtttgttc ccataaagtt gatatgatcg gtaataatca 2185261 ttaaatctcc cgcacggaat tcagtgttga caccgcctgc ggcatttgtc acgatcaacg 2185321 cttccacacc gagcgctttc atcacgcgta cagggaatgt gactttctcc attgagtagc 2185381 cttcataaaa atgaaagcgg ccctgcattg caatgacgga aactccttca agagtgccaa 2185441 gcacaagctg tccggcatgc ccttcaacag tagataccgg gaattcaggt atatcttcat 2185501 atttcagctt gaccggattt tcgatttcgt ccgccaaaat gccaagacct gagcctaaaa 2185561 taaggccgat ctttggagat tccggcaggt tttgtttaat aaaagcggct gcgcgttcaa 2185621 ttctgtcctt caagaaacag tccccctatt gtaataaaga taaaaagctt ttcccgtatt 2185681 tcggtttatt tgtttggaaa ttatcagcga tcgttgcgcc aatatcggca aatgtatctg 2185741 caagcggcag catttgcgct ttcttatgtt ttttgctgta agcgagaatc ggcacatact 2185801 cgcgtgtatg gtcagtccca tgatgaatcg gatcattgcc gtggtcggct gtaataatta 2185861 acagatcgtc ttctctcatt ttttcaaaca cttccggaag ccgcgcatca aattcttcaa 2185921 gcgcgcgtcc gtagccttca gggtcacggc ggtgtccgaa taacgcgtca aaatcaacaa 2185981 ggttcgcaaa gctcagaccc gtaaaatctt ctcccagcgt atcgatcacc ttgtccattc 2186041 cgtccatatt agaaaccgtt ctgcgtgaag aagtaatgcc ttctccgtcg taaatatcag 2186101 agattttacc gattgaaatc acatctaagc cgcagtcttt caattcattc atgacagtgc 2186161 ggtcaaacgg cttcagcgca taatcatggc ggtttggcgt ccgtttgaat tgacccggct 2186221 ctccgacgaa cggccgtgca ataatgcggc caaccatata tttcggatca agcgtcagct 2186281 ctctcgccgt ttcgcaaatg cgatacagct cctcaagcgg cacaacctct tcgtgagcgg 2186341 caatttgcag aacagagtca gcagacgtgt aaacaattaa agcccctgtc tccatgtgct 2186401 cctggccaag ctcatccaaa atcgctgtgc cggaagccgg cttgtttcca ataattttgc 2186461 ggccagatct cttttccagc tcttgaagca attcatcagg aaagccttcc gggaacactt 2186521 taaacggttt atcaatgtat aaacccataa tctcccaatg gccggtcatc gtatctttgc 2186581 cgtttgacgc ttcttgcatt tttccataat aggcaagcgg atgttctgtt ttttctacac 2186641 ctttgatatc ttcgataaga ccaaggccga gctttgccat attcggcata tgtaatccgt 2186701 tcatatgctc ggcaatatga ccgagcgtat gagcgccttc gtcattaaag tcagcggcat 2186761 ccggcgcttc gccgattccg actgagtcca tcacaattaa aaacacacga ttatatttgt 2186821 atgcaggcat cttgaaagcc tccttttttt ctatacgtct attgtatcgc taagaggtct 2186881 gacaactcaa gtataaaccg ttttcattcc cgttgacaat gtatttggaa ataatgagaa 2186941 acttcaatat tttctgtcgc tctaaacaaa aaagccgcag ccacctgcgg ctatgctcgc 2187001 ggatgaaact gcttgtacac atccttcagc cttgttttcg tcacatgcgt ataaatttgc 2187061 gtcgtggata tatccgcatg accgagcatt tcctgcaccg ctcttaaatc tgccccgttc 2187121 tcaagcagat gcgtcgcaaa ggaatgcctg agtgtatgcg gagtcagctc tttcttaatg 2187181 ccggcttcca atgcgatttt tttcaggttc ttccaaaatc cctggcggct gatctgtttg 2187241 ccgtgatgat ttaaaaagag ggcgtcagat acattatttt ttaacagttt tcccctggct 2187301 tttgtcatat attcctcaat ggcggaagca gcggcttcac cgattggcac aatccgttct 2187361 tttcttcctt tgccgaagca tcggataaac cccatagata aatgaacatc agccgttttc 2187421 aattcaatca tttcactgac tcgtatgcct gtcgcataaa gcagctccag cattgcttta 2187481 tcccgatatc cgaaagggct cgtcagctta ggcgtgtcca ataaccgctc gacttcattg 2187541 agcgcgagca ccttcggaag cgcccgttcc gtcttttgtg tttcgatatg aacggaaggg 2187601 tccttatccg ttactttttc cctgagcaga aattgatgaa aagagcgaat ggatgccaaa 2187661 tgccgcgccg atgtcttgcc ggatttcccc gagtccttca aatgctttaa gtattggata 2187721 atatgtatgc gggtaacgtg attccaatct gtaacatgaa gggtttctgt taagtagaga 2187781 gaatagcttt tcaagtcacg ttcataggat acgatcgtat tttgagagag ccctctctct 2187841 accataacgt agtggatgaa atcctttatt tgatctttca ctcttgatct actccccgtt 2187901 ttggtaaaaa aagatcaacc ggtcgaacca tccgcctttt tcatcctgat ccatttcaac 2187961 aacttttaca gcggagcctt ccggtttatc ataccgatga tagttttcat actcttgatt 2188021 cacccatatc atagcataat agaacaaagc ggtaaaaccg gtaaacagga tgaaaacttt 2188081 caatgcatcg acagctgttt tcaggaatct tcccatgtcc taatcgatcc tttccctatg 2188141 gttccagtta tataaaccat atgccaaatc agaaaggttt tatacataga aacagcaaaa 2188201 aaccctttcc ccatgagaaa aggttcgcgc tcggcaccgt ctattcagtt tcttttccgt 2188261 tacagcggtg gcaaatgccg tgaaacgtca atctatgatc tttaatctta aatttccaat 2188321 cacgttcaat gatttcttcc acgtcttcaa gcaaatcttc ttcaatttca tcaacggctc 2188381 cgcactccat gcacaccaag tggtgatgaa agtgagctgc gccctctttc cgaaggtcgt 2188441 aacgggacac accgtctcca aagttaattt tatctacgac ttttaattca gttaataatt 2188501 caagcgtacg gtatactgta gcgagaccga tctcaggaga tttctctttt acgaggaggt 2188561 atacatcttc tgcgcttaaa tggtcttctt cgttttcaag cagcactctt actgtcgctt 2188621 cacgctgtgg cgtaagttta tagctggatg agtgcagttg tttcttaata cgatcaatac 2188681 ggttttccat gtctttccct cctacgccgc attccatgac tcattataac aaaatacgcg 2188741 cagagttcca actataatta ttataaactg ataaataaaa tggttttctt ttaataatga 2188801 ttttaaaaaa gtctagatgt aagcttttcc attaaaacag gagataagta tgcttcaaag 2188861 agagatgaaa tcagcgctaa aaacagaatg accagcagca caaaggcata ccgcccgaac 2188921 cattgaatcg gcgcgtcatg caggcttcgt ttcacgaaca gctgtctgat taactttaaa 2188981 gaaaacgcaa ttgcacatgt gcccataatg agataagccg gaatcagcag cacattttgc 2189041 ggcaaaacgg agacaaatga taggaaaaac ccgcttactc ccatctgatt gactaggaac 2189101 ccgacagtaa agccgacgac gatccctttc agaaagatca taatgaaaat aatcggcatc 2189161 ccaatgacgg aaattcccag tatccacatc aggcctaaat actttgcatt atgaaagata 2189221 ctttgcccaa acatatcagc tgaacttgcc tgttttccat ccgaaagctg tccaaaaaat 2189281 tgacttaagt agtagtataa atcttctttc tggctgatgg tcatactgtt gacaataatc 2189341 gcgccaaaga tgacacccat gaaaaacagc actgacacaa atatataaag agagagatga 2189401 tctttgacat gcctgagaaa catgtcctta taagagattt ttcgcatacc gtttcctccc 2189461 gcccgctcta gtgatttgat ttaatagatt gtatgaaaga aacagaaaaa catgcccttt 2189521 ttcaaaaaga aacaatagag atgaatgcta ggcggctttt tggggcacaa aaaaatcctt 2189581 atcatcaact gctgtatgat cataaggatt cttatgcttc cgtttattca aaatctcttt 2189641 tttgcttttt gtcattcttc catgtgtgct gaaagatggt gtgctgcctc ttgataataa 2189701 gacgtcacgt ccgccgtttc tcaatcgatg cccccgcttc tttttcgctt ggctttttgc 2189761 catgtgatca ctcccttttt tattttcata gtaatgataa caaaattgaa caatgataag 2189821 aaaaaaacag cacctgctac gacaggtgct gtttagctac atttatttca ctgctgtaag 2189881 agctgcatgc tcgacagctg ctgctaccgc atgatggact tttgaatcaa gcggctgagg 2189941 gacaacatca ccttgtttag tgcaagctgc gatggcctct gctgctgcga caagcatatc 2190001 atgattaatc tccgtgcttt ttgcgttaag cgctcctcta aaaatccctg gaaaaccgag 2190061 tacattatta acagaacgcc cgtcagctgc atatgcggcg ccagcctgca gtgcggcctc 2190121 cggctcaatt tccggcttcg gattcgataa agccagaatc acttgaccag aacgtacaaa 2190181 tgccggtttt attaaacccg gaacgcccgt tgtagcaatg acaatatcac atgtttccat 2190241 aagctcctca atactggaaa ctgcctgtcc gccgtattgt tcgagacggt tcattgctga 2190301 ctctgatttg tctgttccgt atacagcatt cacaccataa gccatgaaca tccggcagat 2190361 ggccacgcct gctgcgccaa ggccgatttg ccccactttc gcttccttca ggtcaacccc 2190421 cgcactcctg catgccgaaa tggcagctgc cagcgtcact acagctgtac catgctggtc 2190481 atcgtgcata acagggatgt tcagctcctc ttttaggcga tcctcgattt caaaacaatg 2190541 cggcgaaccg atatcctcaa gaaggatgcc gctaaagccc ggagaaatat gttttactgt 2190601 tttgatgatt tcttcaggat cactcgtatc aagcagtatc ggaatgccgc taatacccgc 2190661 cagctgatca aataaagcag cctttccttc catgacaggc atgccagcca cagagccgat 2190721 attcccaagg cctaaaattg cggttccatc cgttacaatt gcaacagaat tgctgatcgt 2190781 tgtataaata gaagcttttt caggttcttt ttcgatcagt cggcacacgt ccgcaacacc 2190841 tggtgtgtag acacgtccca gctctgccag tgaacggatc ggcattttgc ttttcatttg 2190901 gatttttccg ccttcatgtg cggacaggac ttcatcagat acggtgtgaa gcctgatccc 2190961 ttctccgagg gcctgtacag ccgcgatcac ttcctgaagc tgttcttcat tctccacttg 2191021 aacggtaata ttccgcattg tgtaattggg tccgactttt accgtctcca cttcaccaat 2191081 atccccgccc agaaggccga tggccgtagc cacccttcca agatttccgg gaaccgaagg 2191141 cgtttcgatc atcagtgtcc gaatcatgtg tttcgctatc attcagtgat cctcccctat 2191201 tagcctagtt tttcggcttt aactgtattg tttttcgtat accatataaa ttttcctgta 2191261 taaccataga taattgcaag acctattgct acaaaactga gccacataaa cggcagataa 2191321 gagaaggtag aaacacctaa aataccagcc atgtaaatcc cattatcaga ccaaggaacc 2191381 atccccgaag tcaatgttcc cccgacctct gagttacgtg ataacactct tctgtccaga 2191441 tgtaagcgat catagctgtc ttccataatt ttcggagtca aaataagaga tacatacatc 2191501 gcacagccga agatgtttgc taaaaacgct acgatcagtg tagacaatgt gacattgccg 2191561 gctgaagtta atttcttttc aaacgttgaa acaatgactt ttaacacgcc gagtttctca 2191621 agcagaccgc caaaaccaag gccaaagatg atgacgacga gagaatcaag cataccgaca 2191681 attccaccgc ggtttaacaa gccgttcaaa aattcaacat ccgttttaat agagaagccg 2191741 ttgtacgcag ttgcaatcgc atgggcaata tccattcctt ggaaaacaac agcccagatt 2191801 gcaccgagta aagcgccaat tacgataact ggcatagatg gctttttcat cgccaataag 2191861 actatgacga gaactgccgg gatcagcatc caaatatgaa tgtcaaacgt gttttgcaaa 2191921 gatgatttta agaattcaac tttatcaaga tcaatatttt tcccgccgta cataaatcca 2191981 acaactgtaa agagtatagc tgtaatgaca taagcaggta ttgataaata aagcattgct 2192041 ctcacgtgag ccaatacatc gacttttgat agtgaagaag ctagaactgt actgtcagac 2192101 agcggagaca gcttgtcccc aaaataagca cctgaaagaa tagctcccgc tactagagga 2192161 agcggaatgc ctaacccctc tccaattgcg atcatggcaa tgccggcagt tccgactgtt 2192221 ccccatgacg ttcctgttgc cacagacata atggaacaaa taattaacgt tgccagtaaa 2192281 aagatacttg ggtgaataaa ttccagtccg taataaatca aagtcggcac aacgcctccg 2192341 gcaatccatg ttccgatgag cgccccaact gaaacgagaa tcagtacggc ttcaaggcca 2192401 tttgatatcc catgtacaat cgcattttgt aaatctttat aagaataacc gagtctaata 2192461 cctaaaagca ttgcaataaa ccatgaaaca aaaagcgcca gctgtatcgg caagtcgaga 2192521 aagactgtaa acgatagaac aagtgctaaa aatactccta gtacaataat aatttcaaat 2192581 agtgttggca atcttacatc cttcaaaaga agtccccctt catgtaaaag ctaaaacgct 2192641 ttcaatatat agtgcaacac gtatactata cttcctcatc cctatgttgt aaacagctta 2192701 ttcatccgac tattcggaga tgaataagct gtattttata caaattttat ttttctaata 2192761 gttctttccc tgcgatacct ggtttggtca tctcatatgg gtttaaaata atatccaatt 2192821 cttcttcagt cagcacatca tgctgcagac aaagatcccg gacagattgc cctgtcataa 2192881 ttgcttccct ggcaattcta gctgccgctt catacccaag atgcggattg acagctgtga 2192941 tcacgcctgc gcttttttct acgtattgct tcatacgctt ttcgttggct tcaatgcctt 2193001 ttaagcagtt gtcagtgaac gaacggaagc cgttgttcat gatgctgatg gattgaagca 2193061 aattaaagac aagcacgggc tccatgacgt tcaactcaag ctggccggct tctgaagcaa 2193121 ggcagattgt attgtcattt ccgataacct ggaacgcaat ttggttgatc agctccgcca 2193181 taaccggatt gactttcccc ggcataatag atgaacccgg ctgacgtgca ggcagagaaa 2193241 tttccgcaag tccggcgcgc ggtcccgacg ccattaagcg caggtcgttt gcgatcttcg 2193301 acatgttcat catgcagact tttaatgaag ctgatacctc tgtataggca tctgtatttt 2193361 gtgtcgcatc aacaagatga tcagcgccga caagaggaag cccgctaata tcagcaaggt 2193421 gctttactac ctgtttgata tattcaggat cagcgttcag ccctgtacca acagcagttg 2193481 cgcccatgtt gacttcatac aggtgctggc gcgattgctt gattcgtttg atatcacgct 2193541 cgagaacacg gctgtaagct tcgaattcct ggccaagacg gatcggaacc gcatcttgaa 2193601 ggtgtgtccg gcccatttta ataacagagt caaactcctg tgctttttgc ttaaacacac 2193661 tatgcatatc ttccattgtt ttcagcagtt tttctaagag cttcaatgtg gaaatatgga 2193721 tagcagtcgg gaacacatcg ttcgtagact gtgacatgtt cacatgtgtg tttggactta 2193781 aatggatata atctcccttt ttatgtccca tgatttcaag cgcccggttt ccgataacct 2193841 cattcgcgtt catgttcata gaagttccgg caccgccctg aatcggatcg acgataaact 2193901 gatcgtgcca cttgccttcc agaatctcgt cagcggcttg tacgatagct tggccaattc 2193961 cttcatacag ccgtttcacg tccatgttgg caagagccgc agcttttttc acaatcgcca 2194021 gtgcgttaat catttcctca tggattttgt atcctgtgat cggaaaattt tcagaagcac 2194081 ggagcgtctg aattccgtaa taaacatctg cttcaatttg tttttcccca aggaagtctt 2194141 tttccacgcg atattctttt tggccgttta acataatctt taaccttctt tctctttgct 2194201 ggttatcgtt tttacatttt acaggacaac gtcatcagct atcggcgttt ccataattct 2194261 cttgacgaca ggaagatccg aagactgacc tagcgcccac atcaattttg gcacaattgc 2194321 ttctgtgttc atatttcttg atcggataat taagtcttgg ttgactctgc ggccaacctc 2194381 gtaaatgctc atgtcttcgc cttcttcaag acattgagtc gtaatgacga cgacaatgcc 2194441 gctttcgatc agttcattca cttttgacaa aatgtctctg ccttcaaacg gcactcctcc 2194501 gctgccataa ctctcaatga caattccttt gtacatgctt ttcagggcat caaacatttc 2194561 gggctttaag cctggatgca gcttcagcag acatacatct gtgcatagtg aagtgtcaac 2194621 tgtgaaggtg tcgttctcag gttccgttac ttgtttgttg tattcgatcc cgtcttcatt 2194681 gataaaagcg atatatgggt aattgatgct ttcaaatgcg tcgtagcttt tcgttcttaa 2194741 tttgatcgca cgcgttccct gaatgactct gccgtcaaac acaacataaa cgccgcccac 2194801 gccttcacag gcaaatcgaa tggcatctgt aatatttttt ttggcatcgg ttttttggaa 2194861 cgtgatcgga atctgcgagc cggtgatgac aatcggcttt ttggcatgct gcagcatata 2194921 cgatagtgcg gcagatgtat aggccattgt atctgtaccg tgagtaataa caaacccgtc 2194981 ataggcatca taattttcct taacggcttc tgctatttcc acccagtatt caggctgcat 2195041 attggtgctg tctatattca taagcgactg agtttccatt gtgtaatcgt tatcaagttt 2195101 tgatacgtaa cttaataatt catcagcctt gactccggga gccagcccat tttccccttc 2195161 aactgaagca atcgttcccc cagttgtcaa catcaataat tttttcatac catgcacctc 2195221 ttcactgtat ctaaagatgg gttgcgagaa ggtattcgct tttcgcatac ttttaatgca 2195281 attatagaca cggaaaataa aatacgcaag acattattat tcaattcgcg tacacttcct 2195341 aatacctata tgatataatc agctcaaggt gaaaaaggag cggaagttca tgaatctaga 2195401 tcgtttaact gaattgagaa aaaagaaaaa ttggtcgctt caatatacag ctgaccttct 2195461 cggtatcgca aaaagcacat atgccggcta cgagtcaggc taccgacggc cttcacttga 2195521 agcgcttgcc atgctggctg acctctttga cacaacctgc gatgaacttt taggccgcga 2195581 gaaacaaaag cagactgctc ctcaggccat agaattggcc acgtggagca gcctcgactt 2195641 taccatttct gttgatggcc agccgctgag tgaagatgaa atcatccagc tgattacctt 2195701 tatacgcaca aaaagaaaag tacaggagga actgagttaa tctttagctc acggtttaat 2195761 tttaccgtag gttcctcctc ctccggcttt caattccagt tttccggatc tcgcttttac 2195821 gataagcgcc gcggttttcg gcgggacaac gcgagccaaa tcttcttctg cagcctcatg 2195881 aagaacagcc atttctgttc cgaaggcttt ttttagtttg tccagcgttt tcgggcctac 2195941 acccggaaca aattgcagcg ggatctgatg tacatatcgc ggacgcggga cgcgaacttc 2196001 aagctgatca ctcaattcac gcaatctatc gctgactccc ttggtaaatc tggcttttcc 2196061 gcaattcgcg cacgctgttt ccccgcttac agcaggctct ccgcacgctt cgcaagccgt 2196121 ctgataatat ttccccaata acgggtccaa gccataattt gcgataattt tcctgtcatc 2196181 ttgtcccttt aatgcaagag caaattcagt aaaatcagct gactgcacat ataattcatt 2196241 atattctctg ccgattttcc ccaacgaatg cgcatcagaa tttgttaaaa aaggatacgg 2196301 attcaattgc gatacgtgtg atgccatgtc tgtatcacag cttaatccaa gctccaccgc 2196361 gtctatcata gatggatcaa aaacctcagt taagcttgat ttaacccctt ttccatataa 2196421 gcttttatgc ggcgtaaaga tatgggcggg gataaacagg ccgcccatat cctgcacttt 2196481 tttttgcagg tttaagcccg tttcataaat ccgctgcgag cttaaatgaa tatttttcag 2196541 ccgggctgac agccagtttg aaaactgttt catatcagcc agcgtcggca taaatacgag 2196601 cacatggatc ggtccgctgc aggcttcatc ataaatctcc agctcgctcc ccaataaaag 2196661 agtcgtgctg cgataacgga ttcctccccc gtcaagctcg cgatattttc cagatgaaat 2196721 gccttcctca agctctagaa tgacttccgg agaatgacag tcgataatgc cgaggagttc 2196781 aattccttta tgttcactgg cttcaaccaa aattctgtcc agcgttaatg ttttggcgcc 2196841 tgttattttg acagcccttc ctgtaaaggt ccggccgata tgaatgtgca aatccgcgta 2196901 aatctttttc atttttgtgc ttggagcgct tctttcagct gaagatactg aatcgcgtag 2196961 gctgttttag catcatatac ttcacgcgat tcaaccagct ttagcgcatc ttcaagcgtc 2197021 acctccatca cttcaacaaa ctcgtcctca tcaagctccc gtttttcttc aagcacagaa 2197081 agctcctcag caagaaaaac gtgaacgatt tcatctgcaa atccgggtga tgtataaaac 2197141 gcagttattt ttgtcagttt ttttgctgta taaccggttt cctcttcaag ttcccgaagt 2197201 gccgtatact ccggctcctc acctttttca agcttaccgg ccggaatttc aacgatcgtc 2197261 cgctcaagcg gcttacggaa ttgtttgacc atgatgattt tcccttcatc tgtgacggct 2197321 agtaccgcta cagctccagg gtgtttcaca atttcacgtt tactggcttt gccgtttggc 2197381 agctctacat cctcgacata aagatcaatg actttacccg aaaaaatctg ttctttggca 2197441 attgtttttt cttctaatga tttcatttct tcatctcccg ttctgtctct atatgatgcc 2197501 ccatacattt tatcatacta gagcaaaagg gggcttcttc gtgaaagtgc accgcatgcc 2197561 aaaaggtgtt gtcttagtcg gaaaagcatg ggaaattcga gcgaagttaa aagagtatgg 2197621 acgcacattt caatatgtga aagattggat ctcaaagcca taaaagttga aactttagct 2197681 cctttatatt acggtcaata caaagcctaa aaaaggagtg tgcacatgag aaagcgcaaa 2197741 ttgggtacat ctgatttaga cattagcgaa gtcggactcg gctgtatgtc tcttggaact 2197801 gaaaaaaaca aagcattgtc cattctggat gaagcgatcg agcttggcat caactatttg 2197861 gacacagcgg atttgtatga ccggggacgc aatgaagaaa ttgtcggtga tgcgatccaa 2197921 aacagacgcc atgatattat tctggcaaca aaagcgggaa accgttggga tgacggaagc 2197981 gagggctggt attgggaccc ttcaaaagct tacataaaag aggcggtaaa aaagagcctt 2198041 acacgtctga aaacagatta tatcgacctt tatcagctcc acggcggcac gatagaggac 2198101 aacattgatg aaacgattga agcgtttgag gaattaaaac aagaaggtgt catccgctac 2198161 tacggcattt cttccatccg cccgaatgtg attaaagaat atgtaaaaaa atcaaacatc 2198221 gtcagcatta tgatgcaatt cagcctgttt gacagacgcc ctgaggaatg gctcccgctt 2198281 ttagaggaac atcaaatcag cgtagtcgcc agaggtcctg ttgccaaagg gctcttaact 2198341 gaaaaaccgc ttgatcaagc ttcagaaagt atgaaacaaa acgggtactt gtcctattca 2198401 ttcgaggaac tgacaaatgc ccgtaaggca atggaggaag tggctcccga tctttccatg 2198461 acagaaaagt cgctgcagta tctgctagca cagccggctg tcgcttcagt gattacaggc 2198521 gccagtaaga ttgagcagtt acgggaaaat attcaggcag caaatgcacg gcgtttaacc 2198581 gaagaggaaa tcaaagcgct ccaatctcat acgaaacaag acatttacaa agctcatcgc 2198641 tcatagcaga aaaaccagca cctgtacggg tgctggttta tttatattga tgccaatcca 2198701 tttggctttc atttaggagt tcttcaaagc tcttattttt ttcgatctct tttttctttc 2198761 taatctgttc tgctttttct cttttctgcc tcttttcatc ctcttccttc aattggctct 2198821 tcatctccat aagctttgct ttgatatcgg attgaaggcc gtcttttagc tggtgtttgt 2198881 caatggattt ttgttttttc atgcagactt cccccatgtt ttgttttgaa gccagtttat 2198941 cacggagcat ataaactgaa caagcagact ctcttctgat cactttctca gcgtagcagt 2199001 gtttaggtat aatgatctta aacacgaatt gcctatatat ttcgttgaaa ggtgctgtga 2199061 cttttgaaga aaatcctttt ggccattggc gcgctcgtaa cagctgtcat cgcaatcgga 2199121 attgtttttt cacatatgat tctattcatc aagaaaaaaa cggatgaaga cattatcaaa 2199181 agagagacag acaacggaca tgatgtgttt gaatcatttg aacaaatgga gaaaaccgct 2199241 tttgtgatac cctccgctta cgggtacgac ataaaaggat accatgtcgc accgcatgac 2199301 acaccaaata ccatcatcat ctgccacggg gtgacgatga atgtactgaa ttctcttaag 2199361 tatatgcatt tatttctaga tctcggctgg aatgtgctca tttatgacca tcgccggcat 2199421 ggccaaagcg gcggaaagac gaccagctac gggttttacg aaaaggatga tctcaataag 2199481 gttgtcagct tgctcaaaaa caaaacaaat catcgcggat tgatcggaat tcatggtgag 2199541 tcgatggggg ccgtgaccgc cctgctttat gctggtgcac actgcagcga tggcgctgat 2199601 ttttatattg ccgattgtcc gttcgcatgt tttgatgaac agcttgccta tcggctgaga 2199661 gcggaataca ggctcccgtc ttggcccctg cttcctatcg ccgacttctt tttgaagctg 2199721 aggggaggct atcgcgcacg tgaagtatct ccgcttgctg tcattgataa aattgaaaag 2199781 ccggtcctct ttattcacag taaggatgat gactacattc ctgtttcttc aaccgagcgg 2199841 ctttatgaaa agaaacgcgg tccgaaagcg ctgtacattg ccgagaacgg tgaacacgcc 2199901 atgtcatata ccaaaaatcg gcatacgtac cgaaaaacag tgcaggagtt tttagacaac 2199961 atgaatgatt caacagaata aaaaagcgaa aggcctcttc ggctctttcg cttttttatg 2200021 ttacagaacg tcggtaatgc catccatatt ttctctgatc cattcaatcg caagatctat 2200081 cgttgtaaac tcctgcgtct cgaaggtcat ttcatcctgc aatagccaga catctttctt 2200141 gatggactct gctcctccga ttgaccagtg aagcaaggta taaggatggt tttgattcag 2200201 gaaggatacc cacgttttat tttgtgctgt gttcttcatt gccttcagct tttgttccac 2200261 gtttcgcgtc tcctacttta ctaatatgct cattctgggg ctgagcattt cagccgggct 2200321 tttcagcgcc aatgttttgg ctttttcatt gtaatcgatc gtcatttgat cgtcaaaaaa 2200381 cactttttgc gacgattgga tatacagcgg aatgccgttc gtttccagct gctcgcactg 2200441 tcccgttaat tcttctgcca gccagattgt cgggacaccg cttaccgcgc agccgcatcc 2200501 ttctgcatcg taacgaagct gggctttttt tcccgggttg gcgtcaaacg cctgctgcag 2200561 tgcctgtttt gctgcatctg tcacatgtat gttcataagg tgaaaccccc gttttcatca 2200621 ttttcgctat tgtagcatac aatactgcca ttcgcattgt ttctgccttt tttccaccgc 2200681 ttcgcatttt cttctgcagt cttgatccac tcatctttcc cttgtatata ctgattgatg 2200741 ctgtcagggt gctgggccgc cagctgtttt ttgagaacgg cgtattcttt cgctatgttt 2200801 ggatgagctc tgagataatc tctgaataac agatgccttt caatagcagg gtttccctgt 2200861 tcgtacatat ggacatgatg agtgcgttta tttccgccct tttggaaata acgcctgccc 2200921 gctataccgt tctcaccttt tggtgtatag ccgttggcct tcatttgttc atcaaattgg 2200981 ctcacggctt caatgcttct gacttcaatt aacatatcaa tgattggctt cgctgccatg 2201041 ttaggtattg atgtgcttcc gatgtgatga atagcgataa tctccggccc gaacacaagt 2201101 ttcagccgtt ctttttcttc atcgaaacat tctgcccatt tttcgttgta gagaatgatc 2201161 tcaacttttc ttttcggata caaatgaaag accgacagca atagaccctg cgctgctttg 2201221 acggtttctg ccttttggaa tccggcctgt gtatagagtg acacagccgg ggtattgttc 2201281 tcggctgtga ctacttcgat tttctcagcg tcttcattat gatcaatgac aaattgcaga 2201341 agcgctcgtc caattccttt tctgaaaccg tcaggatgca caacaagcct gcaaatggtg 2201401 agataatgca tgtttttctc atatgaaatg acaccgatca gcttgccgtt tttccgatat 2201461 cccgcaaacc gttcatggga tgcttgaata tcctttacct tctcttgtaa agcgggaata 2201521 ccgtcaaaac cgataatctc tgtttccttt atgtaggcgg ggatctgtac ggctaaaatc 2201581 tcacgcgcta tagtggcttc cttatgctgg agaaattcaa tcattcgtgt tctcctgaaa 2201641 cagccgctgt ctgtcgactt ttgcgacgcg gactgcatac gactcgtacc aaacgcttct 2201701 tcctttttct tttgctgctt gatgttcagt gtgatgcctc caatggttaa ttgcgtccat 2201761 actgtcccaa taggaaactg tgatgcccct tccatccgct tcacgtacgc tttccacgcc 2201821 taaaaatcca ggctgatccg ccgcaagtga taccatccgc tccgctgttt ctccatatcc 2201881 tgtgtcattt tcgcttttga cagaagaaaa aatgactgca tagtaaggag gctcaggtgt 2201941 ttttgataaa aaatccatca tatttccccc tcatatgttt ttgacaaata gtaccctgtc 2202001 ttggcccggg ccatcatagt ttgcaaacac tgagatgcca tttaccgttt tggtgccctt 2202061 ttcaatatca aaccccaatt ttgtgtgata tgcgattgat accttattca caggtgaagt 2202121 gacacacttc acccgggtgc agcccctttg ttttactgtt tcgataaata catcatacaa 2202181 ttgtttccca atttgcattt ttctgaaatc cggatgcaca ccggaaaaat gaatgtacgc 2202241 cgtttcagga tcggattgcg attgaaatcc gattaaaaat cccgtcatgc tgttatgttc 2202301 ggatgtaata aagcttgtgt cctgaaaatg ctcaaaaaat agtctcggca atttttcttt 2202361 cagctgtctg ccgccccacc attcattcag tacagacgtt accatttcat aatctgaaga 2202421 cgtgattgtt cgaatatcca ttacgatttg atctccctcc gtctggcaaa acgaatgtca 2202481 gctctttttc tcacaatata aaaattatat tttgcctggc tggaattgta aatgccttct 2202541 ttcctgtatc atacgtttcc agactgccga gggaacaatg tttgatcatt ttacgcctat 2202601 ttctccccca aacaggagga gagactttac agcacaatat caagcacttg atcaagtttc 2202661 agcttataaa gctgatcctc gtctcctttt atccatactg ctttttcaaa ctcttcatac 2202721 cggcagattt tcccggtgca gcagacaatc tcaccgtcct gaaagcagct gacagtgata 2202781 tcctgagcaa actccatcgc ggcgcaaagc gtttgattca tctcttccag cttatcgggg 2202841 tcaaggatcg gcttttgcag cttctgttta agtcgctttc tctccagcag gctttgctta 2202901 tgttccggca gaaacatcct gctcccttcc cacagcaggt tgcccctttt taaatggtcg 2202961 ttcatttata atgcccccct attttagccg cacgttcaaa tgcctggcct gccgctgtca 2203021 gtgacgccgc cctgatgatt gctgtatcgc cgaatcgatt tttaatgcca tccatcacat 2203081 agcctaggct cattttcttt gcataatcct gaaataaatt gagctgccat atgtcatcag 2203141 atgagagctg agacagattg acaccgaggc ggcggacggg tttcccgtcc caaaatgtaa 2203201 gaaacagccg tcgtacagcc tcatatacat cctgcgtaga attagtcggc tctgccagct 2203261 tcacttgccg gttgaagccc gtcggccaat caaaatcagc accccggcag ctcactgaca 2203321 ctgtctgccc catgaccccg gcgtttcggc ttcgcctgca cacctcttca ctcagctcaa 2203381 gcaatacgac cttgatttct ttgtcaaagt gttcgtagtc tctcgggaga gtcattccat 2203441 gacctatcgc cttttgcccg tccagagacg aagttgacac aggggaatag tcgattccgt 2203501 ttgccgtcat ccacagcacg tggccgttaa tgccccattt cttttttaaa agatcgagcg 2203561 gaaaagccgc gagcccgccg atcgtgctga tgcccattcg atttaaatga tgcttcatgc 2203621 ggctcccgac gccaaacatg ctgcccaccg ggagcggcca catttcggtt ttcatatttt 2203681 ctttcgttaa ggtaaaaata ccgttcttat tctttttggc aaaattgtca cacgcaattt 2203741 tggccagcgc tttgttaggg ccgattccga cccgtgcata aacgccgatc tcccgcatga 2203801 ttctgccctg aatgcttttc gcgatctcca tcggcgtccc aaacagcttc tggctgcctg 2203861 taatgtccat gaactgttca tcgatggaat acggctccac aaggtctgta tactcctcga 2203921 gaatggccgt aatttgcagt gatacatcaa tataccgctg catacgcggc cggagcacaa 2203981 cagcctcagg acacttttcc tgcgcctccc acagccgtga agcattcacc acaccctttt 2204041 gtttcgccag cgggcaggca gccaatacga ctccgcccct tttttcaggg tcacccgaaa 2204101 caatgacggg cctatttttc aaatgtggat tttccgcttt ctctacagat gcataaaacg 2204161 attgcatgtc aacgagaaaa atcacttttt ctttcatcat acacacctct aaaaagaact 2204221 tatgttcgct tttcattata tgcgaaagta tgttcgtttt atactggtaa atgattcttg 2204281 tctgacagaa aatatgatcc aagggtttga gagaagaaaa acatttagta gaataaaagc 2204341 gaagcataag gataggagag tcatgatgga gaaatttgtc gaaaaaatgc tgggacaggc 2204401 attgcggcaa tacggcagaa acgttgctat agatccgtta agcccgtatg aaaaacaaag 2204461 cctgaaagcg gctctacaag agagacggaa tgaagaacca gatgaggatt tgcatgcgca 2204521 tatagaagat atcatttatg actatgtcac aaaccaaggc ctgttctctt aaacgcatga 2204581 ctgtcagttc tttcagccgc tgatgcggct tccctttgaa aacaccgcct gaaacaaata 2204641 aacagtctca ggcttacaga aaaaaagcag gattttctca cgctccatag attcatatgg 2204701 cctggcgtaa aattcccctc aatgctcgcg caaaacggaa taagctgtcc atgatcacgc 2204761 gtatacactt tttcgaagag atgtgctctc ttgttctgtc atgcggtcca tgccggtttt 2204821 cagcgtacat cttgatctca tagccggttt cactgccgat atgatccacg ttctggcggc 2204881 ttaaactaac acaccctcac tgaccaatcg ctttgctttt catcggacat cccgtcattt 2204941 tccttctttc aagatgtaaa ctccgtcagc cacacgcatc ctcaacgcat agtatattgc 2205001 catccataca atcaggcata ctacatgtca ataacgaaat attttgaacg atctattgga 2205061 gaaggaaatt ttttcatata tgatagagaa agatcataca tacaggagag aatataattc 2205121 atgaagaaat ggaaagatat ccacccgatc agctggacaa ttataatcgg aaccattttc 2205181 ggcagaatgg caacatcgat gagcattcct tttttagcga tttatttgac agccgtccaa 2205241 ggcgcatcag cttcctatgc agggctggtc atcgccgcga gctcatcagt cggcatcctc 2205301 gcaagctttt acggcggata tatctcagat aaattcggca gaaaaaacat gatgcttgta 2205361 tcgattttcg gatggatgct ggtatttgca ggctttgcgg cagcatctaa tctctgggtg 2205421 ttttttgtag taaacgcatt aaacggtctt tgcaaatcac tgtttgagcc cgcttcaaag 2205481 gccttgttgt ctgatatgac agaagaaaaa acgagactgc tagtttttaa tttacgctat 2205541 gcggctatta atatcggcgt tgtcttcgga cctgtgcttg gcctatattt cggctcatcg 2205601 caatcgacta cgcccttttt ggtgcctgca gtcatttacg gactatacgg aattgtgctt 2205661 gccctccaat ttaaaaaaca tccatcctta tcagcaccag cccagtcccg aaatatgagc 2205721 gtgcgggaag cgtttatggt cacgcaaaag gattatcttt ttaccattgc tttggtcggc 2205781 attacgctat gcaccttcgg ctactcacaa ttcagttcca cattccctca gtatatggcg 2205841 cagaacccct tgatcggcaa tggaacgaag ctgtatgggc tgatgctgac attaaacgca 2205901 atcgttgtgt tggcgacgca atttcccatt gtccattttg caaaacggtt ttcgccgctt 2205961 tgttctctga tgctcggtaa tgtgatggtt agcatcagca tggccatttt caccgtatca 2206021 cacggtgttc catcaattgt gatgattgtc atcacattta caatcggcga agtgctttta 2206081 ttctctatga tggatttgta tgtagaccag attgcaaaac caggattaaa aggcacttat 2206141 ttcggggcaa tcggtttttc acagctcgga aacgtcatcg gcccttgggt cggggggata 2206201 tgtatagacc tgtttggcgc tggccggccg atttatattt tttctgtcct gagcggcatt 2206261 accctgctcg gcctgccatt tttagcgttc gcctatcggc aaatgaaaat ggagaccaca 2206321 aaacaccgtt cccgtctgga aaagccgctt taaataaaaa acggaagaga atgaatctct 2206381 cccgcaaaca tgaggtgaag aacatgaata taggtgatgt gatgtttcag ctgtttgtat 2206441 ttattatatt tgccgctgtc gtctttgcgg ctgttacagg cttcaagtat gcgaaaaacc 2206501 gaaaagcgca gctggatcgc attgagaaaa agctgaacag cctgtccgaa gatcacgatt 2206561 aacagcttgg ggcaacgagc tctaccttaa tccggtctgg atcctcacaa aagactgcat 2206621 aatgcccgtc tcctccggca aaaggatgcc tgtctcggta caacacacga tagccttttg 2206681 ccgtcaattt ttcagtcatc tgatcgactt gaagcttgga ttcagcatga aatgcgagat 2206741 ggttcagacc gactcggcat ctatggtatt ccggctctag aaatggctct ttcgcctgca 2206801 caatcactag gtaaaaacga tctttcttcc agctgatgcc tgagctccat ttttgatact 2206861 ctttataacc aagttctttt aagaaccagc cccaaaaccg cctagacgcc tccaaatcag 2206921 agacatacag ttcaatatga tgcacatttc ataccctcct taccaacact tcctcgacct 2206981 tatgcccgtc tcccttacgc aaaatgagat ctgacctgaa tttagttggc aaaatatttt 2207041 catataaatt cggccggttg acactctccc aaatcgaggc tgccatctcg tcagcctcct 2207101 gatcggacaa gtctttaaat ttatgaaaat atgaatcagg attttgaaaa gctgtttccc 2207161 gaagcaggcg aaaacgctct aaataccaag tgaaaatccg gctttcctcc gcatccacat 2207221 aaatcgaaaa atcaaagaaa tcggaaacaa aaatacgcgg gttttcccgg tcatcctcca 2207281 aggtgggcga ctgaagaaca ttaatgcctt caataatcac aatatccgcc tgttctacaa 2207341 cctcgaacac accttcctcg cggtcatagg ttagatggga atacaccggg gcctttacgc 2207401 tgtcctttcc tgattttaag tcattcaaaa attcgagcag cgcctttaca tcatagcttt 2207461 caggaaatcc ttttcttgac atcatatttt tctttttcag ctcggcagta ggaaataaaa 2207521 aaccatctgt cgtgataagg ctcacttttg gacggtcagg caaacgcgaa agcagcttct 2207581 gcaagatccg cgccgtcgtg ctttttccga ctgcgacact gccggcaatg ccgataataa 2207641 acggaatttt ggctgaatgt gggtgcttca aaaaaacatt gacatgctta ttgcgttcag 2207701 ccgcagactt gacatgtaaa tgaagcaagc gaacaagcgg aatatagatc gtctccactt 2207761 cttcaacaga tagataatca ttcaatcctt ccacagcttt tgcctcttct tcagatacag 2207821 caatcgacaa atgcccccca aaaccagacc aagactcccg attgtgctgt gtatataaag 2207881 tatgtaggtt aagttcttta tttttcactg tttacacctg actctctgta ggttaaaacc 2207941 cttacaaaga ttgtaacgga aaaccttttc actgtctgct tatttttcat ttcgtttttt 2208001 tagcaaatca gcaccgattc ggttatacgc agccatttca tcttttggaa ccatgcttcc 2208061 tcccgttccc cagacgacat gtacggcatg ttccatctta tatttctgag catagcgcct 2208121 tccctcttct gtcgaaaaaa gctgaaccgg cccgaacatg ccagcaagag cagagggctc 2208181 taaatattta tcttcagata cagccagcat atgaagcaaa gtataaagcg tattgtcctc 2208241 taccgtataa cagccgctca gaagcggttc aatcagcttg ccgacaaatc ctgacggcct 2208301 ccctacggca agtccgtcag cagccgtctg attatccagg ccgatatcct ggacggagat 2208361 cttctcgtga agtcctgaat aaagccctaa cagcatacaa ggtgaatgag ttggttctgc 2208421 gaaaaacaca tgaacatcat ctccgtataa aagcttcagc ccaaatgcta caccgcccgg 2208481 tcctccgccg actccgcacg gcagatacac aaacaagggc gtctcaagac ttggctttat 2208541 attcatacag tcaagctgtg tttttaatcg gcttgcagca acagcatatc ctaagaacag 2208601 ctgacgagaa tgttcatcat caataaaata acagaatgga tcttgttccg cctgccgtct 2208661 cccttcgttc accgcttcac tgtaatctgt ttcgtactcc ataacagtga ctcccttttg 2208721 gcggaggaga tcctttttcc actgcttagc atcggcggac atatgcactg tcacgcgaaa 2208781 cccgagtgcc gcgccgatga tgccgatgct taaacctaga tttcctgtcg aaccgacagc 2208841 aatcgaatag cgggagaaaa acccggtaaa ccgctcttcc tgtaagatgc ggtaatcatc 2208901 ggtttcctga agcattcctt cttgaagcgc gagattttca gcatacttta acacttcata 2208961 aatcccgccc ctcgctttaa tcgatcctga aatcggaagc tcatggtcgc actttaaaag 2209021 ccatcttccg ggaaatggct gctgatatgc cgcttccagc tttcccttca tatgctgcac 2209081 ctcaaaaagc ggagactcga tgattccttt agcgcctttc gtctcaggaa acacctcggc 2209141 aatgtaaggt gcaaaccgct gcattctttt ttccgcttcc gctatctcgg ttgcccactc 2209201 atctgcacgg ggtaatggcc cctctttctt gcctgaattt gcccagaata caggctctgc 2209261 atcaatcagt ttctgaataa acggatcttt aagcagagca tgaaggactt ctgaatgaac 2209321 tgacattcaa caatctctcc cttccactat caaaaactgc cccgtgagaa acaagccact 2209381 ccaccacagg cagttctatc attatttttt catgagcgcg cgtcctgcca gcttttctac 2209441 aagagctgga aacagctgat acagcttagt gccggcattc attaaacgcg gaagattgat 2209501 ctcccgcttt ttcgtaaaaa ttgcagctgt aatttgagct gccacgtcat caggatcaag 2209561 catccagcgg ccgacatttt tggcgtagtc cccgccttta tcagcaatgg aaaaaaagtc 2209621 cgtctgaatc gggcccgggt tgactgttgt cacataaatg ccggttcccg aaagctccat 2209681 ccgcaaagcg tttgagtaac ctaacacggc atgtttggtc gcggaataca ggctagactt 2209741 cggtgtggcg attttccccg cttgagaggc gatattgatg atatgtccct ttttttgctc 2209801 aagcatttgc ggaagcaccg cttttgtaca ggcgatcagg ccgaagacat tcacatcaaa 2209861 catcgctttc atgtcatcca atgtagagtc taaaaccgtt tcaaatatac cgaagcctgc 2209921 attgttaatc agtacatcaa tcgagccgat ctgatcgcgg acccgggcga tatcctctag 2209981 gcggccgaca tccagaggaa aaatctcaca ctgtccgctc cattcctcgg ttattttcct 2210041 tttgatttct atcaaacgat cctcgcgtct agccgacagc aggacatggg ctccttcagc 2210101 cgcgcataag tatgcgattc tttctccaag ccctcctgaa gcgccggtta tccaaatcct 2210161 ttttcccgct atatgtttca cccatttcac ctcttcattg ttttaaagta tacggtattt 2210221 ccttcccaat atgacgtgat ggcttcttca gcctccaaca catcaaggtg acctgccgtt 2210281 tctgacatcg ttaaaaacaa ttccttttca tatacagcag gaaaaagctg ctgacagacc 2210341 tgaaaagcgg tcatcggctt ttcatccagc atgcgacgca catcctccgt cctgttcctc 2210401 tgcttgtcaa aacgcttctc aatcagcgct tgtacactgg tgataggctc gccgtgacca 2210461 ggaaatacga ttgttggatc aagttgagac agccttcgca atgaccgctg ataatccact 2210521 aaaggctttg acctgacgtc tcccgctttc ggcgcttcca aaatcggatt agacgagctg 2210581 tttgccagca gtagatcgcc gccaagcatc cttccgcttt tttcatggaa cagaacaata 2210641 tgcgattcag catgtccagg catctccaac acagaccagc cctcaagccc atctatgccc 2210701 ataccttctc tgattgattt tgtcagagat ctcgtacagg aaaatgcgta cgctgatcga 2210761 atcagctttt ccgccttccc cgtatcaaat ggaacgccta attcaggcag cagcttttga 2210821 aaaaaacgtt tttgccaatc cataaaggct tgattttggc tgatataagg ttcgttgaat 2210881 gtatgcccaa tcacttcgat ttcatctgaa aagacatcaa gcaagcctgc atgatcagca 2210941 tgatggtgag tcagtacaac ctgctcgata tctgacaatt tcacatttac agcggcaagc 2211001 tgctcttgta aggctctggc agcctctttt gtattcggcc cggcatcgat aagtgtcagc 2211061 gcatcacctt ttacgaggta aacgataaca tcgccgacag caaacggtgt cgggacgcgg 2211121 atcgcaatta catcttcagt tgtcatcctt tcgctccttg tcttcattca ttattcatat 2211181 tttagctttt tctcggtctt gtgtcattat tgcagaatga gaacaaacct ttttgaaaaa 2211241 gctattgaca ttagcttgtc cgccattgca taatgaacaa caaactaaaa cgagaaccat 2211301 tggaacgcta tgacgaggaa tagtatacaa ggcaatggcc taagagagcg atacccccgg 2211361 ctgaaaggtg ttgcggcccg cttgtttgta gaacctgccc tcaagtcgcg gttaggaaaa 2211421 cctaaacgtt tcccgcgtta cggggatttg agctgagcac aatttgtgct aatgagggtg 2211481 gtaccgcgaa ccttttcgtc ctttacgtga tgaaaaggtt ttttgttgtt ctaatagaag 2211541 gaggatatca atgaaaaaga taggatttgt cggcgccggg tcaatggcag aagcaatgat 2211601 caacggcatt ttgcaaagcg gcatcacaaa accagaacat atctatatta caaatcgctc 2211661 aaatgacgag cgtctgattg aattaaagga aacgtacagc gtgcgtccat gcagagataa 2211721 aaatgagttt ttcactcaca ccgatatcat tatcctcgct ttcaaaccga aagacgcggc 2211781 ggaaagcatc gacagcatcc ggccgtatat caaggaccag cttgtcattt cagtacttgc 2211841 aggccttacc atcgaaacca ttcagcatta ttttggcaga aagctcgcgg tcattcgcgt 2211901 catgcctaat acatcagcgg caatcagaaa atcagcaacc ggattttccg taagcacgga 2211961 agcaagcaag aatgatatta ttgccgcaaa agctctattg gaaacaatcg gtgatgcaac 2212021 actggttgag gagcggcatc ttgacgctgt cactgcaatc gcaggcagcg gcccggccta 2212081 tgtgtatcgt tatattgagg cgatggaaaa agcagcacaa aaagtaggat tagataaaga 2212141 aacggcaaaa gcactcattt tgcagacaat ggcaggggca acagatatgc tcctccaaag 2212201 cggcaaacag ccggaaaagc tgcgtaaaga aatcaccagt cctgggggca ctacagaggc 2212261 aggtcttcgc gctttacagg actcccgctt tgaagaagca attattcact gtattgaaga 2212321 aacagctaaa cggagcgcag aaatcaaaga acagtttgcc ggtgccgcct tagagagaca 2212381 ttcttagatg taaggacaaa aacagaaggc acagtgcctt ctgtttttta tttttcccgc 2212441 agcagctggc cggcagattc tgattgcttt aatagcgcgg agatcgtaaa tgaaagcaaa 2212501 tcgggaagca cttcaaagga ataaggcata tacaatcttt ccgtccattt atgcgggtct 2212561 ttaccagccg gaccgacatt taaaactggg acatataaag cctgattttt accgcttggc 2212621 aatgaatacc ctctgttaaa gagcggcata ttgcttgtgt atgcatcaac ctcctgtttt 2212681 tccagctgaa gataactcaa gtccgaaagt ccggggaagt actgaacctc ccgtaatgca 2212741 atgccgtatc gctcagccgc ataatgcttt atctgatctg ctgtatttct gatcaattga 2212801 tcatcctttg aagaaacagc tggataaagc ggcggactat aaaacagaac gatgagcggc 2212861 gcatcctcct tacaaagcga agcaagctca gaaacaattt tcgtcgaaaa atccctgtct 2212921 ccaagctccc ccctgttagc aaaggcataa tttagagccc gctctgtttc cgagatcccc 2212981 gcacgctttt ttgcacgcga gaccagctca tcaaatgtca aaacagtgac gtcccgctca 2213041 atcggctgaa atggctcaaa ttgttgaaaa tcctgtgttt tcttccgaac gttcgacatg 2213101 atttcctccg ccgcctgttc tgctgtttta agcagcatct gatgcagctc actagctgag 2213161 cgtttcattg acagcacatt aaataatgtg acggctgtat gcggtgtctg gactgaatat 2213221 gcctctttca agtccttttg cattaagttt accggcggcg gagtgacctc gccatcaacc 2213281 ttttcgcaat aatcagcatt cagttcaagc aaacggttaa tctcagatac cattaaattt 2213341 gcgtttagac ctgaaaacgg ctctccaaca tgtgtctcaa tccccttgca gaaaaaaccc 2213401 gcaagcacct tgccaatgct tcctgtataa aaatattgct gctgatcgcc gggaaatttt 2213461 tcaaacatcg gttcggcatt caggcaagcg gttaatgtga tatcatgctt tttctccatc 2213521 tccttcaatg caggaaccgc ttcaatcatg cctcttgaat tcacttcctc gtccggaacc 2213581 gttatcaaca gcagattgcc ctcaaaatgc ccgttcattg ccctctccag catcgacagt 2213641 tgaatacaaa gccccgcttt catatccatc gtccctcttc cgaacagcca gtctccgctt 2213701 tcggcatctc ttctcacacg ttccgggagc agctcttttt tctctaaaaa ggagctcaaa 2213761 agctcagcag gcttgcaagc catatgttta aattcgccgt aatcttctat gtcaacgaca 2213821 tcaaaatgac tcagcagaag cactgtcttt ttgacattct tctttttgac tagagccgta 2213881 agaaaagatc tgccatcgtc catcggatga agtgttacat catcagggtg cttttgaaaa 2213941 tagggcttgt ccttcaaaat aaaataaaga tactctgcaa gcgctacctc gccctttgaa 2214001 ccggtgatgc tttcgtattg cacaagagaa gttaaaagtg ccagcaattc gtccttcgtc 2214061 tgccaattca ttgattccgc ccctcctatg aataaaaatg cttctatact gaaaaataaa 2214121 ctgatttctc gtctattata cagaaatgtt tgacaaaagc ggttcatttg agcagtttat 2214181 atgacgggaa agaaatgact tgatataatc aatctctaaa aaccttacgg gaggcgaaag 2214241 aaatggccag aaaattattt acacctatta caattaaaga tatgacgtta aaaaaccgca 2214301 ttgtcatgtc gccaatgtgc atgtattctt ctcatgaaaa ggacggaaaa ttaacaccgt 2214361 tccacatggc acattacata tcgcgcgcaa tcggccaggt cggactgatt attgtagagg 2214421 cgtcagcggt taaccctcaa ggacgaatca ctgaccaaga cttaggcatt tggagcgacg 2214481 agcatattga aggctttgca aaactgactg agcaggtcaa agaacaaggt tcaaaaatcg 2214541 gcattcagct tgcccatgcc ggacgtaaag ctgagcttga aggagatatc ttcgctccat 2214601 cggcgattgc gtttgacgaa caatcagcaa cacctgtaga aatgtcagca gaaaaagtaa 2214661 aagaaacggt ccaggagttc aagcaagcgg ctgcccgcgc aaaagaagcc ggctttgatg 2214721 tgattgaaat tcatgcggcg cacggatatt taattcatga atttttgtct ccgctttcca 2214781 accatcgaac agatgaatat ggcggctcac ctgaaaaccg ctatcgtttc ttgagagaga 2214841 tcattgatga agtcaaacaa gtatgggacg gtcctttatt tgtccgtgta tctgcttctg 2214901 actacactga taaaggctta gacattgccg atcacatcgg ttttgcaaaa tggatgaagg 2214961 agcagggtgt tgacttaatt gactgcagct caggcgccct tgttcacgca gacattaacg 2215021 tattccctgg ctatcaggtc agcttcgctg agaaaatccg tgaacaggcg gacatggcta 2215081 ctggtgccgt cggcatgatt acagacggtt caatggctga agaaattctg caaaacggac 2215141 gtgccgacct catctttatc ggcagagagc ttttgcggga tccatttttt gcaagaactg 2215201 ctgcgaaaca gctcaataca gagattccgg cccctgttca atacgaaaga ggctggtaat 2215261 gcccataaga gatatcctgt agaggatatc tcttttttta tttttagaga aacgatcggc 2215321 taaggttctc cgtctcccta gtagaaccaa ttagaggaga tgactccaat gaaatcagct 2215381 tggatggaaa agacatatac aattgacgga tgtgcgtttc atacacagca ccggaaagga 2215441 tcaagcggtg taacgattgt ctttgaggcc ggctatggta cttcttctga gacgtggaaa 2215501 ccattaatgg cggacattga tgatgaattt ggcattttca catatgatcg ggcaggcata 2215561 ggaaaaagcg ggcaaagcag agctaaacga acagctgatc aacaagtgaa agaattggag 2215621 agtttgctta aagcagctga tgtaaaacct ccttatttgg ctgtttcaca ctcatacgga 2215681 gctgtcatca ccggtttatg ggcctgcaaa aacaagcatg atattatcgg catggtcctt 2215741 cttgacccag ctttaggcga ttgcgccagc tttaccttta tacccgaaga aatgcacaaa 2215801 tcacatacga gaaagatgat gcttgagggc acacatgcag agttttcaaa aagtctgcag 2215861 gagctcaaaa agcggcaagt ccacttagga aacatgcctc ttcttgtgtt gtcatcagga 2215921 gaacggactg agaaattcgc tgctgaacag gagtggcaaa acttgcacag cagcatattg 2215981 tctctatcta accaaagcgg ctggattcaa gctaaaaaca gctcccacaa catccatcat 2216041 gatgaacctc atatcgttca cttggctatt tatgacgtat ggtgcgcagc gtgccagcag 2216101 gccgctcctc tttaccaggc agtcaattaa cgtaaaaaaa gaccgggccg taagggattc 2216161 ccggtctttt atattatttt gtttcacggt gaagggtata tttctttaaa cgcggtgaat 2216221 attttttcag ctccaaacgg tctggattgg tgcgtttatt ttttgttgtg atgtaatttc 2216281 ggtctcccgt ttcagtgcaa agctaaagta acatttactc tcataattaa catctcctta 2216341 taaaacgtaa tgattacgtt ttattataca acgtcatcac aaattgtcaa ataagagctc 2216401 cgccttcagc ctcgcgggac gtttacctct aagaaatcat atgccgccac gctattgggg 2216461 aaaacgtcaa ccgcttcttt ttgaagctcc aaagaagcat ctccctgata tcttgcgctg 2216521 atatgggtta aaatgagctg cttcgctctt gcttctttcg ctgttacagc cgcttgttcc 2216581 gttgtactgt gataataatc ataagcaagt ttacggtctt ccttagcaaa ggttgcttca 2216641 tgaacaagca catcacaatc cctcgcaagc tcttttagtt tgtcacttac tctcgtatca 2216701 ccggagaaca caacagatct tcccttttta ggaggctcca gaaaatcatt cccattgatg 2216761 attcgtccgt cttcaagcgt taccgtttcg ccttttttga ttttctgata tacaggtccg 2216821 ggcgggatgt tcatttcttt taatacgtca gccttcaagg aacccggtac gtctttttcc 2216881 tgcacacggt acccgaaggc ttccactcca tgaataacag ataccgctgt gacaataaac 2216941 tgatcgtcct caaacacgat tccttcttca atttcctgga tcgcaagcgg atatgtcaaa 2217001 tgggttttcg tgacggcaag gcttgtttca ataaacgcct tgatcccttt aggtccgtac 2217061 actgtcagct cgtcctctcc gccttgaaag gaacggctcc ccagaagccc cggaagtccg 2217121 tatacatgat cgccgtgcat gtgtgtaata aagattttct ctattttacg aggtttaatc 2217181 gttgtatgta aaatttgatg ctgtgtggct tccccgcagt caaaaagcca taccgaacgc 2217241 ctttcttcaa gcaattttaa tgccaccgac gttacatttc tcgccttggc ggggatgccg 2217301 gctcccgtcc ctaaaaaaag taattccacg tttccttcct cctactagaa ccagatacct 2217361 acaagaatac aggatcaagc ggaaaatgtg aatcttgcct ctgaaaagaa caatcctttc 2217421 gtgctagaaa cattttttca gcattctgct taaaaaaggg cttaaatgtt tgctttcgtt 2217481 gaattttaga tttaaaatga aggaaatata cggggtgtac taaaataaag cttcgaataa 2217541 agtgaggtac ttttagtgaa aacaaaccaa caaccaaaag cagtaattgt catattcggt 2217601 gcaactggag atttagcaaa acgaaaattg tatccgtcta ttcaccgttt atatcaaaac 2217661 ggacaaatcg gagaagagtt tgcagtggta ggagttggaa gaagaccttg gtctaatgag 2217721 gatcttcgcc aaactgttaa aacatccatt tcctcatctg cagataagca tatagatgat 2217781 ttcacgtctc atttttacta tcacccgttt gacgtgacaa accctggttc ttatcaagag 2217841 ctaaacgtat tgcttaacca gctggaagat acatatcaaa ttcctaacaa cagaatgttc 2217901 tacttggcaa tggctcctga attcttcgga acgattgcaa aaacattaaa atcagagggt 2217961 gtaacagcta caaccggctg gtcccgcctt gtcatcgaaa aaccgttcgg ccatgatctg 2218021 ccaagcgcac aggcattgaa taaagaaatc cgcgaagcat ttacggaaga tcaaatttac 2218081 agaatcgacc attatctagg caaacaaatg gttcagaaca ttgaagtgat tcgatttgcc 2218141 aatgcgattt tcgaaccgct ttggacaaac cgctacattt caaacattca aatcacatct 2218201 agcgaatcac taggcgttga agaccgcgca agatattacg aaaaatcagg cgcccttcgc 2218261 gacatggtgc aaaaccatat tatgcagatg gttgcccttc ttgcaatgga gccgcctatc 2218321 aaattgaaca cagaagaaat ccgcagcgag aaagtgaagg tgctgagagc actgcgtcct 2218381 attgcaaaag acgaagtgga tgaatacttt gtgcgcggac aatatcatgc tggtgaaatt 2218441 gacggtgtac cggttcctgc ttatacagat gaagataatg tcgctcctga ctccaataca 2218501 gaaacctttg ttgccggcaa gctcttgatc gacaacttca gatgggctgg tgttccattc 2218561 tacatcagaa ccggaaaacg aatgaaagaa aagtccacaa aaattgtcgt tcaatttaag 2218621 gacattccga tgaacctgta ctacggtaat gaaaacaaca tgaatccgaa cttgcttgtc 2218681 attcatattc agcctgacga aggcattacg ctttacttaa atgctaaaaa gcttggcgga 2218741 gcagcacacg cacagccaat caaactcgat tattgcagca attgcaatga cgagttgaac 2218801 acccctgaag catatgaaaa actaattcac gactgtcttc ttggcgatgc aacaaacttt 2218861 gcacactggg atgaagttgc cctttcttgg agctttgtcg actctatttc tgaaacatgg 2218921 gcagcaaaca aaaccttatc tcctaactac gaatcaggct caatgggacc gaaagaatct 2218981 gatgatcttt tggtgaaaga cggcttacac tggtggaaca tataataaga agaaaaaagc 2219041 cgaaatagtt tactaagcat tttcggtctt ttttacgctg aacaaaggta taacaatctc 2219101 cttaataaca aaacccccaa agcttaagag cttcgggggt ttctattgat tacttcatcc 2219161 attcagtatg gaagatgcct tctttgtcag tacgctcata agtatgagcg ccaaagtagt 2219221 cgcgctgtgc ttggattaag tttgcaggca gtacggctgt gcggtagctg tcatagtagg 2219281 ctaatgcgct tgagaatgat ggcaccggca caccttgggc aactgcaagt gaaatcactt 2219341 ggcgaagcgc tccttgatag ctttctacaa tattcttgaa atagctgtca agaagcaggt 2219401 tgtcaagctc aggctcgcga tcgtaagctt ctttgatctt ctgaaggaat gccgcgcgaa 2219461 tgatgcaacc accgcggaag atcatagcga tttcaccata tttcagatcc cagttgtatt 2219521 cttcagaagc agctttcatt tgggcaaatc cttgcgcgta tgaacagatt ttactcatga 2219581 acaacgcttt tctgaccgct tcaatcagct cttctttatt ttctgtaaca ggcttcactt 2219641 ctggtcctga aagaagtccg ctcgctttta cacgctcttc cttcatagct gagataaagc 2219701 gtgcgaatac agattcagta ataatcggaa gcggaacgcc taagtcaagt gcgctttggc 2219761 ttgtccattt tcctgttcct ttttggcctg ctttatcaag aatcacatca acaagcggtt 2219821 tgcctgtttc ttcgtctttt tttgtgaaga tgtcagccgt aatctcaatc aggtagctat 2219881 caagctcacc tttattccat tcagcgaaaa cttcatgaag ctcatcagca gaaaggccca 2219941 gcacctgttt cagaatgaaa tatgattcag agatcagctg catatctccg tattcaattc 2220001 cgttgtgcac catttttacg taatggccgg cgccgtccgg accgatatat gtcgtacaag 2220061 gttctccgtc aacttttgca gaaatggctt caagaatcgg ttttacaagc tcatgtgctt 2220121 ctttttgtcc gccaggcatg atagaaggtc ctttaagcgc tccttcttct ccgccggaaa 2220181 cgcctgttcc gataaaatga atgccgcttt cagcgagttc tttgttacgg cgctgtgtat 2220241 ctttatagta tgtattaccg ccgtcaatta aaatatcatc cttctctaga tgaggaagaa 2220301 gagattgaat tgtcgcatct gttgcagttc ccgctttaac cattaataag attttgcgcg 2220361 gtgtttccaa ggattggaca aattcttcaa tgctgtaagt gccaacaaca ttttttcctt 2220421 ttgcctcctg taaaaactcc tcagttttac tgcttgatct gttgtaaaca gaaacagaaa 2220481 atccccggct ttcgatattt aaagccagat ttttacccat gaccgcaagt ccgataacgc 2220541 cgatttgttg ttttgacata ttctaacgtc ccttctgcaa acgtttaatc attttaaaat 2220601 ttaaattaaa ataaaatgat atttataata aagaaattac catacattca cccttttttt 2220661 caagcgattc agcttttctt ttcatcttga aaaaaatctt tattaaagct tgttcccttt 2220721 gttttgctct cctctttttt taacgttgcc ccttttctga tcagtttggt accgtacttt 2220781 ttattcagct tttccatcat ctgctgaatg ggctcatcct tcgcatcttc attaaagctg 2220841 aacaaatcga gctgtttata ggcctgctct ttttctacta aatccgttcc ggtaatgcca 2220901 agcagcctga caggattttt attccaatgt ttaaaaaaga ggtgctccgc ttctttcaaa 2220961 atgtcatttt tttgatcaat cgggtttctc agcgtagtgc ttcttgtgat ggttctccaa 2221021 tccgcatatc taatcataat aaaaagcttc gaagccatga cttccttgcg ctgtaaacgg 2221081 tcactcacag aagcggcaag ctttctaaaa acgcctaaca gctcttcttc atcactggaa 2221141 tcatgggaaa gtgtcgatga gttgccgacg cttttaaatt cgtaaatgcg ctccgggtca 2221201 accggcgcat ggtgaatgcc atttgcttta tttttaaggc gcggaccgtt gatgccaagc 2221261 aggcgcttca gcgagtgttc atcagctgca gctagctctc cgattgtatg gatgccgagt 2221321 cccttcagtt tttccgctgt ctttttgccg actccgtgca tctctccaac aggaagcggc 2221381 cacaggatat cgggcacttg cctctttctt aagatcgtaa ttccaagcgg ttttttcata 2221441 tcagacgcca tcttagcgag aaatttattc ggtgcaatcc ctatgcttga cgggagcagc 2221501 agctcttttt gcagcctgct ttggatttct tttgccgtct ctagagcgcg gctgctgtat 2221561 ggtgtatcgg tcatgtccat atagccttcg tcgatggaga caggctccac taggtcagta 2221621 tattcacgaa gaatggtaaa catcgctcgt gaagagtttc tatagcggtc aaagttcggc 2221681 ggaagaacga tgagctcagg acaatggcgc ttcgcttgcc aaaccggcat cgttgttttg 2221741 acgccgcgcg ctcttgcttc gtagctgcat gttaccacaa tgccctttcg ctcctttacg 2221801 tttccggcaa ctgcgaccgg ctttccccgg agagccggat catatgccat ttcaaccgac 2221861 gcataaaagc tattcatatc aatatggaaa ataattcggc tctttcccgg cataaacaaa 2221921 tctccttttc ggtcattaga caacagcttg tacatatagt aaaatgaagc tattgaatgg 2221981 atgtgatgac aatgtttgtg gaatcgataa atgacgtttt attcttagtc gattttttca 2222041 caattattct tcctgctcta acggcaatcg ggattgcatt cctcttacgg gagtgccgtg 2222101 cgggcgagca atggaaatca aaacgaacag atgaacatca gacggtcttt cacattaacc 2222161 gaacagactt tcttattatt atatatcatc gcattacaac ttggatacgt aaagtcttcc 2222221 gcatgaattc gcctgtgaac gatgaggaag acgccggttc tcttctttta taaaccgcat 2222281 ttataaaaag gaggagaaca aaattgttaa aaacatatca aaaacttttg gctatgggta 2222341 tctttttgat cgtattatgc tcgggcaatg ctgcatttgc agcgactaat caggtgggag 2222401 gcctcagcaa cgtaggtttt ttccacgatt atttaatcga accgttttcc gctctgctta 2222461 agggtgttgc cgggctgttt cacggagaat acggactctc tattatcctc gtaaccatta 2222521 ttgtgcgtat agttgtattg cctttgtttg tcaatcagtt caaaaaacag cgcatcttcc 2222581 aagagaaaat ggccgttatt aaacctcagg ttgacagtat ccaggttaag ttgaaaaaga 2222641 cgaaggaccc ggaaaagcaa aaagagctgc aaatggaaat gatgaagctg tatcaggagc 2222701 ataatatcaa cccgcttgcg atgggctgtc ttccaatgct gattcagtct ccgattatga 2222761 ttgggcttta ttacgcgatt cgctcaacac ctgaaattgc gtcacactcg tttctatggt 2222821 tcagtttagg gcaatctgat attctcatgt cccttagtgc agggattatg tattttgtcc 2222881 aagcctatat cgctcaaaaa ctgagcgcga aatattccgc tgtcccgcaa aaccctgcag 2222941 cgcagcaatc cgcaaaattg atggtgttca tcttccctgt gatgatgacg attttctcgc 2223001 ttaatgtgcc ggcagccctt ccgctgtact ggtttacaag cggactgttt ttgacagtgc 2223061 aaaacatcgt ccttcagatg acgcatcata aaagtaaaaa aacagccgct cttactgagt 2223121 cggtgaaata aaaaagcaac cccgtgcaaa aagccggggt tgttttttgt tacttgcaaa 2223181 gtaccgcgcc aaacagtctt gtttatcatg gctgaagcag aaatggccat cctaaaaaat 2223241 agccgtatcg tttaaaaaga aggaaatcgg gaataccttt actcacctcc aaccgaaagg 2223301 agcctatacg ttgacggaac gctttcagca aaaaaatatt tctgtacctg atggaatctg 2223361 gatcatgaga caaacctgga atgatgtctt atttgctcac tggcctgttg atgtttctat 2223421 ccttcgcgct ttggtaccgt ccgttttaga attagataca tataacgggc aagcttggat 2223481 cagcatgctt ccctttatgc tcacgaacct gagggcgcgt tatctccctg tcattcccgg 2223541 tgcgcgtgca tttcctgagc ttaacctccg cacctatgtc acgtataaag gcaagcccgg 2223601 catttatttt tttagcttag atgccgatca tcgtctggcg gtccttggcg ctcgcacatt 2223661 ctttcatctg ccttattttt acgcggatat gaagtccgaa aaaaacggtg atgccattga 2223721 ctatgtcagc aagcggaaaa atgacaaaga agcagcattc cacgccgcat accggccaat 2223781 ttcagcgcct tttacagcag aaaaggattc gctcgattac tggctgacag aacgatacag 2223841 gctctacacc acttatcgca ataagctcta ttacgaagac atccatcatc atccgtggct 2223901 gctgcaaaac gccgaagcag aaatttcagt caatacggtg actgatgctc acggtattac 2223961 attgccggag tcagacccct tgcttcatta tgctaaaaaa caggatgtgt tattttggcc 2224021 gcttaggaaa tggagctaaa aaaacccgat gcgggaaatc gcactcgggt tttctttttt 2224081 tattttgccg cctcttcaat aatggcaaca accatttctg ccgttttaac gagctcttcg 2224141 atcggcattt tttcattttt tgtatggatt tgctcataac cgacagcaag attgaccgtc 2224201 gggatgccat gaccagcgat tacgttcgcg tcgcttccgc cgccgctcgt ttgcagctcg 2224261 cttggacgtc cgattttagc agccgctttt ttcgcgattt caacaacttg gtcgccgtct 2224321 tgatatttaa agcccggata cataacctca atttcgactt ctgcgcgtcc gcccatatca 2224381 gcagctgcct cttcaaaagc agctttcatt ttttgaacct gagcttccat tttctcagga 2224441 actaaagagc gcgcttcagc aagaatatga acttcgtcgc acacaatgtt tgtttgtgtg 2224501 ccgccttcaa accggccgat attagctgtt gtttcttcat cgatacggcc caatggcatt 2224561 tttgagatgg ctttgctagc gattgtaatc gctgaaatgc ctttttcagg ttcaaccccg 2224621 gcgtgagcgg ttttcccgaa aattgccgct cttaccttcg cctgtgtcgg cgcggccaca 2224681 atgatatttc cgacttttcc gtctgaatca agagcatagc cgtaggatgc agtgatcata 2224741 gaacggtcaa gcgccttcgc tccgatcaga cccgattctt cccctactgt gatgatgaat 2224801 tcaatcgtgc cgtgttcaat attttcttct ttcagcacct taatcgcctc aaacattgca 2224861 gccaatcccg ctttatcatc agcacctaaa atcgtcgtgc cgtcagtttt gacgtaaccg 2224921 ttctctacaa ctggttttac gccgtttccg ggtacaactg tgtccatatg agatgtaaaa 2224981 tagatcgtat ctgtttgttt tgtccctttt agcgtgcaaa tcaggttacc ggctccgtgg 2225041 cccgtgatat ccattgtatc gtcttcttta acgtccacac ctaaatcaga aaattttcgt 2225101 ttcagcactt tgcagatttc agcttcgtgc tttgtttctg agtcaatttg gacaagctct 2225161 aaaaattctt ccagcaggcg tttttcattc accatttgta agtccctcca tattaaagcg 2225221 gtatgttacc gtgctttttt ttcggtctct cttctgtctt atgtgtaagc atatgaaaag 2225281 cttgaatcag tcttcccctt gattcttccg gcaaaatgat gtcatcgacc attccacaag 2225341 cggccgcttt gtatgggccg gcgttttgct ttttgtattc agcagttttt tcgcgtttcg 2225401 tcttttgcgg gtcagctgaa gctttgattt ccttttcata caaaatcgat gccgcacctt 2225461 ctggacccat cactgcgatt tcagcattcg gccatgcaaa cacaaggtcc gctccgatcg 2225521 ctttgctgtt catggccaca taggcgccgc cgtacgcttt tctaatgatg agtgtgactt 2225581 ttgggacagt cgcttcagca taagcaaaca ataattttgc tccatgcctg atgattccgt 2225641 tgtgctcttg ctgaataccc ggcagaaacc ccgggacatc ttcgacagtc aacagcggga 2225701 tatcaaatgc gtcacaaaaa cggatgaacc ttgctgcttt atcagcagcg tcaatcgtca 2225761 ggcttcccgc cagatgcttc ggctggctcg ccacgatgcc gattgctttt tcacccagcc 2225821 ttgcaaaccc aatgacaatg ttcttcgcaa aaaatggctg aatctcaaaa aaagactgcg 2225881 ggtcagccag ctccctaatc accttccgaa catcataagg ctttgtcgta tcagcaggga 2225941 caagacggtt taataacggt ctggacgcct ctttctctgg cttcggctct gttgtccggc 2226001 cattcagcgg caaataagac agtagttttc tcacccctgt cagaacctcc ttctccgtat 2226061 gcccggaaaa gtgggcgttt ccgctgacgg cattatgtat ccccgctccg cctaagctct 2226121 ccgcatcaac ctgttcccct gtcacttttt caatcacctt cgggccggta ataaacatcc 2226181 ggccagtctg ttcagccata aatataaaat ctgtgagtgc cggagaatat acagcgcctc 2226241 cagcgcacgg ccctaaaata accgatattt gcggaatgac tccggaatat aagacgtttc 2226301 ggtaaaatat gtgaccgtat ccatctaatg ataacacacc ctcttgaatt ctcgcaccac 2226361 ctgagtcatt cagcccgata atcggcgcct tattttttgc tgccagatcc atcaaagcgc 2226421 agattttcct ggcatgggtt tcgccaagcg cccctccgta cactgtgaag tcttgcgcaa 2226481 atacataaac tgagcgaccg tcaattgtgc cgtaccctgt cacgacccca tcccctaaca 2226541 tgcgctgttc tcttgttaac acttgacttt ccatgaaggg gtgtaattcg ataaagctgt 2226601 cctgatctag aagaaatatg atcctttccc gagcagtgag cttgcccttt tgccgctgct 2226661 gagccagctt ttcccgtcct ccgccttctt ctgcctgctt gcgtttcgtg taaaaatgat 2226721 ccatgtgctc attcatgctc attgtgttgg tctcctttcg gttcacaaag ctctacaaga 2226781 acaccgtttg tttcccgagg ggaaataaac gcgatctttt tcccgttcgc tccctgtctt 2226841 ggaaacctgt caatcaattg aacatgctga tcagacaatg cttgaagctg ttcagatagg 2226901 cagttgcaca aaaacgcaat atgatgcagt ccctgccctt tcttctccaa aaataaatgg 2226961 acggggctgt cagctgtcaa cggctctatc agctcaagtt tgacgctacc agcttgaaaa 2227021 aaagcaacat tcaccttttg ctcttcaacc gtttcttgat gaagaaatgc aagccccaat 2227081 acattttcat aaaagcttct tgcatctttt atcgaaaaaa cggctatccc gatatggtca 2227141 agcctgttca ttttcatccc tgctttcgct aatagatatc gcttgtccgc ccattcaaaa 2227201 cacgctaaaa tatagacaga ttgtttaagg agtgaaaatc atgtctcaaa aactgatgaa 2227261 aagcgttttg atcgtgattt tgggagtttt tattctttca actgtactct caggaatcgt 2227321 catgtttcta taacgataaa aaagcaggcg ccttattcaa tgggaatatc ctgctttttt 2227381 atcagagctt tatgctcgat ggcaatctcc tcaaaagagc ggttgtcgtc cgtgatcagc 2227441 actctcgttc ctactggtat cgtttgaaac aaatgaacaa cctcatcgtt atgcatacgt 2227501 atacagccgt tagacacaaa ttttcctact gattcctctc ggtttgtccc atgaattcca 2227561 taaatccgcc cgtccgttcc tttcgcgtca aatccgatcc atcttgcccc aagcgggtta 2227621 tcaggagatc ccccttcaat atttttcttt ctgtagtaag gattttccgc ttttaccgtt 2227681 accgaaaact ctccttcagg cgtcaaatca tctgtttttc cagtcgccac actatacacg 2227741 ccttctactt tgttgtcgag gataacagca agttcatttg ttcgcttgtt gacaataaca 2227801 tacggatcac ccggcagcgg attttcgccg agcggccaaa tcggtgaaat catcatgaaa 2227861 atcgaacata agaaaaaacg cataagctcc tcctttttca ttaggttgac caatgaagga 2227921 agagctcatg cgaatcatcc gagtgatttt tgcgctttta ttcctttaaa ataactttta 2227981 atcactaaat attgttccat ttcgccgaga agatggaaga gagcggccct cgcttcaaat 2228041 tcctctctag tcgcaggaag cggcatctcc tcaaattctt ttctcatgtc agcaagtctt 2228101 ttcagaaatt tgtatgctgt attcccaggg tgtatcgcct cccgcaaatc atgaataaat 2228161 tcagcgatca tttttccctg atctaccgtg atggagatcg atgtcacttt agggagaagg 2228221 cgttcgataa tttcaaattg cttttctctc attttaaaat aatgataatg cagattttca 2228281 taacgcaaaa tgtggttttg cacatctcga tatgccaggt ttttagcctc cgtaatgagc 2228341 tggtgcgttt ccggaatttc ttttcctgac caatcttgct caccagttaa caaataccgt 2228401 tcgatttctg caaaaatgac agcaaagtta tcctctatct ttttgcggta ggcaatcagt 2228461 ttccggtcaa gactaggcat atacaagttc atcaatagag cgacgccgat gccaaccgta 2228521 atcagctgaa cttcattcca gatgaaagta ggcgtaatgc cgccggacat gtataaatga 2228581 aggataataa cagaactggt gacgataccc tcgttaattt ttaacagaac cgttatcgga 2228641 atgaatatca aaagaagcgc tccgatcaca aacgggtggt agccaataag ctcgaaaaag 2228701 agataagaaa aagcaattgc cagacagcat gccgaaaagc gggcccatga ggcctgaagc 2228761 gaccgttttt gtgtgatttg tatgcacaaa atggtgatga ttcctgctga tgcgaagttt 2228821 tgcaaatgca ataactggct tatataaata gccaaagctg ttccaagcgc ggtctttatt 2228881 gtgcggtaac caattttaaa catgtcggac tccatttcta tttgtttctt caataaaaaa 2228941 gaagaggcgg ccagccttct tcttttttat attctataat attttctcta aaaagtcctg 2229001 cgctcttttg gattttggcg acataaaaaa ttccttcgga ttgccgtctt cgacaatcat 2229061 tccttggtcc ataaacagca cacggtctgc cacttctttt gcgaagccca tttcatgtgt 2229121 gacaatcacc atggtcatgc cggtttcgac cagctctttc atcacctgta gcacttcttt 2229181 gaccatctct ggatcaaggg cggaggtcgg ctcgtcaaac agcatgatgt ccggattcat 2229241 cgcaagagcc ctggcaatcg cgacacgctg tttttgtccg ccagacaaac ggtttggata 2229301 gtcatttcgc ttttcaaaca aaccgacttt gcggagcagg tcctcagctt tctcctgtgc 2229361 agcctgtttt gattcttttt ttacattgac aggcgcgtac atgatgtttt cgagaaccgt 2229421 tttgtgcgga aagagatgaa aatgctgaaa aaccatcccg atgttttccc ggacctttaa 2229481 tgtgttggtt ttcggcttcg taatctctgt gtcttttatt gtaatggttc cgccgttagg 2229541 cttttccaac aggtttaaac agcgtaagaa cgttgatttg cctgagcctg aaggaccgat 2229601 cacggcaaca acctcaccct cagcgattgt tgttgaaatg ttttttaata cttcgtgttt 2229661 cccaaatgat tttgacagct tttcaacctt aatcattgga tttcagcttc ctttctacag 2229721 ccttgccgat aaacgttaaa atcaggacaa gcacataata aatcaatccc gcgataatga 2229781 gcggctcaag gtaattgtaa gtggcggcgc cagcttgata tgcgcgtctc atgacatcac 2229841 caagcccgat gacggtgacg atcgccgatt cttttgttaa cgtaattaat tcattcacaa 2229901 ttgcaggtga tatatttttg aaggcctgcg gcagcagcag atccttcatc atttttccat 2229961 acgggacacc gagtgcaaca gcagcttctt tttgcccttt atcaatggca ttgattccgg 2230021 ctctgataat ttccgataca taagcggcgg aattcaaaga caatgcgaca accgcagccc 2230081 aaaactggtc aatttgaaat ccgagcagct gaggaaggcc aaaatagaca atcataagct 2230141 gcagcactaa aggcgtgcct cggaacactg atgtataaaa atcagcgatc cagataaacg 2230201 ggcggaatgt gctgatcttg cataagctta gcacaatacc gagtataagt ccgataatag 2230261 cagatacaac aacaattttt aatgtaattg ccaagccttc taatataaaa ggaatttggg 2230321 ggatcgttgc tgaaaaatcc aaattcatag cctttgtctc cttttcttac aggaaaaaag 2230381 tttcctattc aataaaaagg ctcaacgaaa aagttgagcc gctttttttt acttctcgcc 2230441 agtgaaccat tttttcttca atttctcaag ctctccgtta tcttccattt ccttgagcgc 2230501 tttattgaat ttgtctgtca gttcactgtc ctttctgaaa gcaattgctg aaccggcttc 2230561 ttccgctttc gcatcaggaa tcacaaagcc ttgcaggtca tcatttgatt tgaaataccc 2230621 ttctgcaaca atgtcttcaa taatcgcggc atcgaagcgg tcagatttga tttcctgcac 2230681 caaatcagaa attctgttgc ggtcttctgt tttaaaacca tattccggag aaagctcttt 2230741 ccccttctct tcctgaatag agccaagctg aacgccaact gtttttcctt tcaggtcttt 2230801 caaagattga atgccgctgt cttttttgct gacaatcata tggttcgctg tgtaatacac 2230861 atcggaaaaa tcaacttgtt ttttacgctc aggcgttggt gtcattcctg acagaacgag 2230921 atccacctgt tttgatttaa gcgctgtaat taagctgttg aagtccatat cctgcacttc 2230981 aatttcatag cctgccttct ttgccagagc ttttgccagc tctacatcaa agccgacaat 2231041 attatctcct tctttatatt caaacggttt gtaatccgcc gaagtaccca taattaattt 2231101 tttctttccg ctttctgaac ctgaattgct tgagccgcac gcagttaatg caaaggtgat 2231161 gcaagcagcc acaagtaata agagccattt tttcatgatc catttccccc gtattcatta 2231221 cttttggtgt atttgaatat ttattcgtta atttgtattt taaacagttt ctcattttta 2231281 tgcaatacta tttttaaaaa ttatctttag gcttatcttt ccagtgatct cttctgatat 2231341 tactagataa aaattaaatc gctgtacaat ccgattgaat aatcccttaa tatttattca 2231401 tatatccttg gaaatttatg cacaaaaaaa cccgggctgc tttgagcatc cgggttgttc 2231461 gtcttatact tcttcacaat attcttcaaa ggcttcctgc agctttgcca ctacagccat 2231521 cggctcatgg ccttcaattt catgacgctc taccattttc atgatctttc cgtctttcaa 2231581 aatcgcaaag gacggagaag atggtggata accttcaaaa tagtcacgcg cacgcgctgt 2231641 cgcttcttta tcctgtccgg caaaaacggt gacgagctga tcaggtcttt tatcatagtg 2231701 aacggaatgg taggctgccg gtcttgcaat tcctccggcg catccgcaaa cagagtttac 2231761 catgacgagc gtcgttcctt ttttcgtaag tgcctcatcc acctcttcgg ctgttttaag 2231821 ctcggtgtat ccggcagctg ttatttcttg tctcgcttgg cggacaatat cattcataaa 2231881 taaattaaag tccatgttca atgaagacct ctcctttttc atcatctgtt cttatgatag 2231941 caaggaaacg tccatatcgg caaatgactt tgcttcgccg tgcacttttt ttgctcttcg 2232001 tttactgctt acagaaaaag gggattatat aaccagaagt aaaataaagg agcagttgta 2232061 tatgagccac cggaaagcgt tactgattca taacggaaat gccggcaaca aaaatataga 2232121 aaaagcactt ggtgctgtgg tgccggtttt atctcaccat ttagatgagg tgattattaa 2232181 acagacaaag aaaaaggatg atgcgtatca tttttgccga tccattgatg attctgtcga 2232241 caccgtcttc attctcggcg gcgacggcac gatccatcaa tgcataaatg ctatcagcgc 2232301 tctagaaaga aaacccgctg tcggaatttt gcccggcggc acgtgcaacg acttttcaag 2232361 agtgcttggc atccctcaaa atcttgcaaa ggccgcggaa gcacttatgg cgggaaaaaa 2232421 aaccagcgta gacgtatgtc agatgaatga ccgttatttt ttgaatttct gggggatcgg 2232481 cttaattgca gaaacgtcga atcaaatcaa cgaaacggaa aaagcattat tgggaaaaat 2232541 cagctatttt acaagtgcct tgcgaaccgt ctcatctgct gcatcgtttc cgatgacatt 2232601 aaaaattgat ggagaagaaa ttaaagaaga agccgttatg ctgcttgtga tgaatggcca 2232661 atacattgga acgaatcgaa ttcctctgcc cgatgccagt attgaagacg gcttacttga 2232721 tgttctcata tgccgcaata ccaacctcac cgcgctgcgg gagctgatga gcatggaaca 2232781 aggctcaatt gatcgtttta ctggagagtt gtcctatgtc caggcttccc gtatcgagat 2232841 tgaaacagac actgccaaaa aggcggatat ggatggagaa gtttatacac atacacccgc 2232901 agtcattcag gtcctgccac agcatatcga catgcttgtt cccgcaaatg aataactgtc 2232961 ataaggcttt agaaagattt tgcaaatccg ttgactctcc cctaggagga ggtcttacag 2233021 tataagggat acacacttga aaaaggggaa gtcatatgga gaagaaaaat attaccttaa 2233081 ctatattatt aaccaattta tttattgctt ttttggggat cgggcttgtg attccagtaa 2233141 cgccgaccat tatgaatgaa ttgcatttat cggggaccgc ggtcggctat atggttgcct 2233201 gcttcgctat tacacagctc attgtctcac caatagccgg acgatgggtt gatcgcttcg 2233261 ggcgcaagat catgatcgta atcggcctgt tgttctttag tgtgtcggag tttttgttcg 2233321 gcattggaaa aacagttgag atgttattta tctcccgtat gctgggcggt atcagcgcag 2233381 ccttcattat gcccggggtc acggctttta ttgcagatat cacgaccatt aaaacacggc 2233441 caaaagcgct cggttatatg tcagccgcta tttcaacagg atttattatc ggccccggca 2233501 tcgggggatt tttagcagaa gtccattccc ggctgccttt tttctttgcg gcagcttttg 2233561 cactgttagc agccatttta tcaatcctca cgctgcgcga gccggaacga aaccctgaaa 2233621 atcaggaaat aaaaggacag aagacaggct ttaaacgaat ttttgccccc atgtatttca 2233681 tagcttttct cattatctta atttcgtctt ttggtttagc atcatttgaa tctttatttg 2233741 cattattcgt ggatcataaa ttcggattta cggccagcga cattgccatt atgattacag 2233801 gaggagcgat tgttggcgcc attacgcaag tcgtcttatt cgaccgcttc acaagatggt 2233861 ttggcgaaat tcatttaatt cggtacagct taattctctc gacgagtctg gtattcttgc 2233921 tgacaacggt acattcatat gttgcgattc tgctggtgac agtcaccgta tttgtcggat 2233981 ttgatctcat gcggcctgcg gtaacgactt acctgtcaaa gattgcggga aatgaacagg 2234041 ggtttgccgg cggtatgaat tcaatgttta caagtatcgg caatgtattc gggcctatta 2234101 tcggcggaat gctgttcgat atagatgtaa actatccttt ctactttgca acggtcacct 2234161 tagccatagg gattgcactg accattgctt ggaaagcgcc tgcacatctt aaagccagca 2234221 cgtgataaga agcgcattct ttgtgtactg caaagaatgc gcttcttctt tatactgatg 2234281 atagaaggag tgatggcatg aaggaatcgt attactcaat tggggaagta tcaaaactgg 2234341 caaacgtgtc gataaaagcg ctccgttatt acgataaaat tgatttattt aaaccagcct 2234401 acgtcgaccc ggataccagc taccgctatt atacagattc tcagctcatt catctggatt 2234461 tgatcaaatc attgaaatat atcggcacac ctttagaaga gatgaaaaaa gcacaggact 2234521 tagagatgga agaactgttt gctttttata cagagcagga gaggcaaatc agggagaaat 2234581 tagacttttt atcagccctg gagcaaacca tttcattggt gaaaaagcgg atgaaacggc 2234641 agatggaata tcccgcgctc ggtgaggtgt ttgttttaga tgaagaagaa atacggatca 2234701 ttcagacaga ggcagaagga atcgggcctg aaaacgtgct caacgcctcc tacagcaaat 2234761 taaaaaaatt tatcgagtca gcagatggat ttacgaacaa tagctacggc gctactttct 2234821 cttttcagcc ctacaccagc attgatgaaa tgacttaccg tcatattttc acacctgtat 2234881 tgacgaataa acagatttca tcaattacgc cggatatgga aatcacaacg atccctaaag 2234941 ggaggtatgc gtgtatcgcg tataattttt cgcctgaaca ttattttctc aacttacaga 2235001 agcttatcaa atatatcgcg gaccgccaat taacagttgt cagtgatgta tacgagttaa 2235061 tcataccgat tcattactcc ccgaaaaaac aagaagaata tcgagtcgaa atgaaaatac 2235121 ggatcgctga ataataaagc atagaaaaag agcatttttt gaaacaaaac ttcaaaaaat 2235181 gctctttttg cttatttagt aaacagatgt cttctcgtca atcgattcta aaatttgttt 2235241 cactcgtccg aggaatcgtc cgcacacgag accgtcaagc actctgtgat ctaatgacag 2235301 gcacagatta accatgtctc tgacagcaat catgccattg tccatgacaa ccgggcgttt 2235361 gacgatggat tctacttgaa gaatcgcagc ctgagggtag ttgataatgc ccatcgactg 2235421 aacagacccg aacgaacctg tgttgttgac ggtaaacgtg cctccctgca tgtcatctgc 2235481 agtgagtttt ccgtctctta cttttttagc taggccggta atgtctttcg caatgccttt 2235541 aattgttttt tcatcagcgt ttttaatcac cggaacaaat aaagaatcct ctgtggcaac 2235601 tgcaattgaa atattgatat cctttttctg aataattttg tcccccgccc acatgctatt 2235661 catttgcggg aattctttta acgcctgagc gaccgctttt acaaaaaagg cgaagaacgt 2235721 taaattaaag ccttctgtct tcttaaaaga atcttttata ctgttgcgat atgcaaccat 2235781 atttgtgacg tcgacttcca tcatcgtcca agcatgcgga atttctgttt tgcttcgctt 2235841 catattggaa gcaattgctt ttcttacacc tgtgacaggg atttctttat caccggctgc 2235901 agacgcagga tatgacgtct cttcttttgg ctcaggtttt gatgcagact tcggtgcagg 2235961 agctgctgtt ttcagctcct caggattctg ttcttgcacg ccgcctgttt caattaagcg 2236021 ctgaatatct tttcgtgtga tgcgcccgcc ggcaccagtt cctgtcactt gatcgaggtc 2236081 aatgccgtgc tctccggcca aacggagaac agctggcgag tagcgctttt tattgggctg 2236141 atcggctgct ccagcacttt ttgcaacagg gttctcagcg gcttctgatg ctgctggctg 2236201 ttcttgtttt tgttcagccg gattcgcgcc ttctgtttca attttgcaaa tcatttctcc 2236261 gacttgcagg gtttggcctt cttctcccac aagctctgtt atcgtaccag taaaagaaga 2236321 cggaacctct gcatttacct tatctgtcat gacttccgcg atcggatcgt atttgttcac 2236381 tttatcaccg ggggcgacaa gccatttgct gatcgtcccc tctgttacgc tttctccaag 2236441 ctgcggcatc gtcatttgtt caattgccat gattgtatcc tcccttacgt ctttaaaact 2236501 ccgctaattc tctcatcgcc gcttccactt tatcagggtt gaccataaag tatttttcca 2236561 ttgtcggcgc ataaggcata gccggaatat caggacctgc aagccgtttg atcggcgcgt 2236621 ctaagtcgaa cagacaatgc tcggatataa ttgcggctac ttcgctcatg atgctgcctt 2236681 cttttgtatc ttctgtgacc aaaagaacct ttccagtttt ggacgcagct tcgatgatgg 2236741 cttctttatc aagcgggtaa actgttctta aatccaccac atgcgctgaa atgccatctt 2236801 tttcgagacg ttctgcagct tgtaaggcga agtggacaca caggccgtat gtgatcactg 2236861 tgatgtcgtc gccttccctt tttacgtccg ccttgccgat tggcaggaca taatcatcag 2236921 ccggaacctc gccctttatc agacggtatg cccgcttgtg ctcaaaaaac agcacggggt 2236981 cttcgtcacg aactgcggct tttaagagcc ctttcgcgtc atatggtgtt gatggcatga 2237041 caattttcag tccgggctgg ttggcgaaaa ttgcttcgac tgattgagaa tgatacaggg 2237101 ctccgtgcac gcctccgccg tatggcgctc tgacgacaat cggacagctc cagtcattgt 2237161 tgctgcggta gcggatttta gccgcttcag aaataatttg gttgactgcc ggcataatga 2237221 aatcagcaaa ctgcatttca gcaatcggtc tcattccgta cattgccgct ccgataccga 2237281 ctcctgcgat tgcagattca gcaagcggcg tatccataac gcgctcttcc ccaaattgtt 2237341 catagagtcc cgctgtcgct ttaaacacac cgccttttct tcctacatct tccccaagga 2237401 cgaaaacgcg agaatctcgt tccatttctt ctttcatcgc caaattgatt gcatcaatat 2237461 atgacattac tgacatttgt tcttcctccc tacttcgcat aaacataatc aagcgctgac 2237521 tcaggagctg catatggggc gttctccgct tcatccgtcg cttcatttac gattgccata 2237581 atttcatcca gcatggtttg ttctatctca tcggacagca ggcctgtttc ctttaagtaa 2237641 gcttgataag taagcagggg atcacttttt ttcgcttcct ctacttcttc acggcctctg 2237701 tagctgctgt catcgtcatc actggaatgt ggtgtaaggc ggtaagaaat cgtttcaatt 2237761 aatgtcgggc cttctcctct gcgtgccctt tcgcgtgctt ctttaaccgc ttgataaact 2237821 tccagcggat catttccatt cacagttacg ccaggcatcc catagcctat ggcacggtcg 2237881 gaaatgttct cacatgcgac ttgcttatcg taaggcactg agattgcgta tttgttgttt 2237941 tcacacatga aaataaccgg cagcttatgg acagcggcaa agtttgcccc ttcatggaaa 2238001 tcgccttggt ttgaagaccc ttccccgaat gtaacaaagg ctgcgatatc ctttttctcc 2238061 atacgtcccg caagcgcaat accgactgcg tgcggcactt gcgttgtaac cggagatgat 2238121 cccgtcacaa tgcggttttt cttttgtccg aaatgtcccg gcatctggcg gcctcctgag 2238181 ttcggatctg ctgcttttgc aaacccggac atcattaagt cctttgctgt catgccaaac 2238241 gcgagcacga cacccatgtc tctgtagtac ggcaatacat aatccatttc acggtcaagt 2238301 gcgaaagccg ctcctacctg tgctgcttcc tgtccttgac aagagattac aaatggaatt 2238361 ttgccagaac ggtttaacag ccacattctt tcatcgattt ttcttgctaa cagcatggtt 2238421 ctatacatat caacggcttc ctgatcagtc agccctagtg cttgatgtcg gtttgtactc 2238481 attcaagccc ctcctttatg cttttaaaaa tgaatggctt tgccatctgc ggcaagcgca 2238541 gcttctccaa ttgcttcaga aagcgttgga tgcgggtgaa tcgtttgccc gacctcccac 2238601 ggtgttgcgt ccagcacttt ggcaagaccc gcttcagaaa tcatgtcggt gacatgcggg 2238661 ccaatcatat gaacgccgag aatatcatct gtatctcggt cagccacgat tttgacaaaa 2238721 ccgtcgcttt caccgtatac aagcgctttt ccaatcgcca taaatgggaa cttgccgatt 2238781 ttgacattat gcccgttcgc ctttgcttcg tcttcggtta agccgacact ggcagcttca 2238841 gggcttgagt aaatgcactt cggcacaagc gtcggatcaa gcggatgcgg attgagacct 2238901 gcaaaatgct caacagcaat aattccctca tgtgaagcaa cgtgagctaa ctgcaggcca 2238961 ccgattacgt ctccgattgc ataaatatga gattccttcg tttggcagct ttcattgact 2239021 gaaatcatgc cattttcagt aacaatatcg gtgttctcta ggccgatgcc ttcgatattt 2239081 gcctgtctgc cgatggaaac aagcattttc tcagcagaat aggtaacggt ttctccgtct 2239141 ttttccgctt gtatgctgat atcgtctgat gtttttgtca ttgtgtcagg cagcactttt 2239201 gcccctgtta tgaactggat gccttttttc ttaagaagac tttccatttc ttttgaaatc 2239261 tctagatctt cagtcggcaa tatgcgatcc gcgtattcaa taaccgttac cttaacgcca 2239321 aaatcatgaa gcatagacgc ccattcgata ccgataaccc ctccgccgac aatgatgatt 2239381 gactgtggca gctcctccat ttggagcgcc tcatctgaag tcagtacaga cttaccgtcc 2239441 acttcaagac ccggaagcat tctcggtctt gatcctgttg caatgatcac ttgtttcggg 2239501 atcagcatgt cattttcttc gccatttccc cgctcaacag aaattgttcc cggcagcgga 2239561 gagaagattg acggtccaag gatacgtcca tatccggtgt acacgtcaat ttttcctttt 2239621 ttcattaaat gatttacacc cgctgcaagc ttatcaacaa cggcttgctt acgctgctgc 2239681 actttttcaa agttgaggga cacgccagcc gtttccactc cgaattgatc ggcttcacga 2239741 gctgtccggt atacctctgc gcttctaagc agcgctttac tcgggataca gcctttatgc 2239801 agacatgttc ccccgagttt ttccttttcc acaacggctg tttttaagcc gagctgagcg 2239861 gctctgatgg ccgcaacata accgccggta ccgccgccca gaatgactac gtcatactca 2239921 gttgccatgg tgactcactc ctgtctgtct attcaatacg atattgtttg gattgctctt 2239981 cgccctgcaa tactcttagc gccccttggg caagagactg cagttcattt tcacccggat 2240041 aaactaaaac gtctgaaatc caatctatgt atgatctgat agcagaaaca aagctttttc 2240101 cgtacgcaag gcctcccgtc agcacaatcg cttcaacttc gccttttaac gccgcgctgg 2240161 ctgccccgat ttcctttgct acctgatatg ccatggcatc ataaatgaag cgggcttttt 2240221 catcgccccc ttgaatcatc tgttccactt ttactgcatc atttgtaccg agatagccta 2240281 aaagtccgcc ggtgccaaca agctttttca tgatttcttc ttttgtatat tcccctgaaa 2240341 aacatagatc aacaagatct cccgcaggca ctgttcctgc tcgttcagga ctgaatggtc 2240401 cctcgccgtg caggccgtta ttgacatcca ccactcgccc gcggtcatgg acgccaattg 2240461 taatacctcc gcccatatgg gtaataatca ttttcatgtt ctcatatcgt ttgccaaggg 2240521 aggctgccgc tttacgagcg acagcttttt ggtttaacgc atggaaaatg cttttccttt 2240581 caatttcagg catgcctgaa actttcgcaa gcactgacat ttcgtctacg acaacagggt 2240641 cgacgatata cgaagggata ttcaggccgt cagcgatttc ccgcgcgata atgccgccga 2240701 gattagaagc atgctgaccg gcgtagccgc ttttcaaatc ctcaatcatc tcatcattca 2240761 ctacgtaggt cccgccttca attggccgga gaaggccgcc tcttgcgcag actgcatcaa 2240821 actttgaaat attgattccc tgttcatgaa gcgtttcgag aatatggttt ttacgaaatt 2240881 catactgatc aataattcgg tcaaatcgct gcagctcttc tatgttgtgt ctcaatgttt 2240941 tttcaaaaat gcttctttcg ttatgaaaaa caccgatttt cgttgaagtt gagcctggat 2241001 taattgtgag aatgcgtttt tcgtcatgta gcactttcat aacctccaga tcaatttctt 2241061 aacgtctgct taatacactg tggccgtttt gcaaaaactg gcttcttgag cggcgcatgc 2241121 gttcaatccg ttcctctgct aagcggtcag ccgctaaata tgcaggaatg ccgtcacgct 2241181 gagaaatctc aagtacacgc tcgatattgc cgtaaatgcc ttcaactttt ttcaatgcac 2241241 gttctgcatt atagccgtaa agctcatctg ccacgttgat gacaccgccc gcgttaatca 2241301 cgtaatccgg tgcataaacg atgcccattt cgtgaatttg atcaccatgg cgtgtctctt 2241361 ttaattggtt gttagccgca cctgcgatca ctttcgcctt cagctgttta atggtgtcgt 2241421 cgttaatagt cgcaccaagg gcacacggcg cataaatatc gcagtcttgt gaataaatgt 2241481 catcaggatc taccgcacgg gcgccaaaat cttcaactgc acgctgtaca gattgtttgt 2241541 tgatatccgt aacgattaag tttgctcctt cttcatgcag gtggcggcaa aggttatagg 2241601 ctacgttccc aacaccctgt acagcaatgg tttttccttc aagagagtcg gttccgaaag 2241661 cagctttagc tgctgccttc attcctctgt acaccccgta cgctgtgact ggggacggat 2241721 ttccagaaga gccgaaagca ggagaaatcc ctgtgacata gtctgtctca tcatgaatga 2241781 tatccatatc ctcgaccgtt gtgcccacat cttcagccgt gatgtatctg ccattcagtc 2241841 cttgaatata gcggccaaac gcgcggaaca tttcctcatt tttgtctttg cgcggatcgc 2241901 cgataatgac tgtttttccg ccgccaaggt ttaagcctgc cgccgcgttc ttataggtca 2241961 tgcctcttgc caatctgagc gcatcttcaa ttgccgcttc ttcattttca tatgtccaca 2242021 ttctcgttcc gccaagcgcc ggaccaagcg ttgtatcatg aatggcgata atcgctttta 2242081 atccagattg ttcatcctgg cagaatacca attgttcgta atcgtatttc tccatatatt 2242141 taaaaagttc catgttcgtt cctcctaatg tgtgtattct tcagatgcgc atattgccag 2242201 cgcaatggaa tacagtttat tttcagcaga gtccgctctg cttgttaaag caatcggtgc 2242261 ttttgctcct gtaatgacag ccgccacgct ggccttggca aaataaatca gtgatttata 2242321 taaaatattg ccggcctcaa ttgttgggac gagaaggata tctgcgttgc ccgctacgtc 2242381 tcccgaaatt tttttctggg ccgcggcaat ttgtgaaact gcgttatcca aagcaagcgg 2242441 tccatcaaca atgcagcctt tgatctggcc ccttttgtac atttgagcta gagcagctgc 2242501 attcacggtc gcttccattt tagggttcac cgtttcgacc gctgcaaggg cagctgcttt 2242561 tggcatattg ttccccactg catgggccac atgaacggca ttttgcaaaa tctgccggag 2242621 ctcttccagc gaaggagcaa tattcattgc cgaatctgtc acaaacatca gccggtcaaa 2242681 atccggtata tcgaagacag ccacgtgaga aaggacactt gctgaccgaa gcccctcctg 2242741 tctgttcaat accgctttaa gcaaaacaga agtcggcaca ttgcctttca ttaaaacgtc 2242801 cgctgtttta tgatgcacag cacgaaccgc taatttcgcc gattcctcag gagtattggc 2242861 atggacgatt tccacttgat gcccttgcat ggatgatgtc agctcgttca gttttttgct 2242921 gtcgcccgtt aacaagaaac gggcggatag gtgctcggct gccagcttta cagcccggat 2242981 cacttcctca tcctcagcat gagcaaccgc aatggtctta tttttgtgta tcgacgcttt 2243041 gccgattaaa tctttcagct tcatctgtta ccacctttct tgtttcgact ccgcctttta 2243101 ttatgcaagt tccatgccag ctcttaaggg tgctgtcata ccaggtatac cgaaacattc 2243161 gtgcagatgt ttgcgtttat tctgcaaatt attgcatgcc ttcatttgca aggccatatt 2243221 tatccatttt gtaatataaa ttccgaatgc tgacaccgag agcttttgct gtttttgtcc 2243281 ggttaaaatg atgcttttca agcgtttgct ggatcaaatg cgcttcaaat ttttctactg 2243341 cgacagacag cttttcgcct tcaatatccg gaaaatcaaa acctgttccc tgatctgtgt 2243401 cattttcttt ttgctcaagt tcgaatacag gcaagtgatc tttttcaatc cattccatat 2243461 gcggattcag aaaaatcatg gctcgtccaa ggacattttc aagctcccgg acattcccag 2243521 gccaatggta ggcagataag gcgcgcaagg cttgctgtga gagccctttt acattcctgc 2243581 cgtaatcccg gttgatcttt tggataagtc tgacgctcaa tgcttcaatg tcctccaacc 2243641 gctgccgcaa aggcgggatg gagatcggat agcgattgat ccggtaatac aggtcttccc 2243701 ggaatgttcc gtccgccatc gccttttcaa tatttacatt tgtcgccgcg atcactctga 2243761 cgttgacagg gatcgctttc gtgccgccca ctctgacgat ttccttttct tgaaggacgc 2243821 gtagcaattt ggcctgcata ttttgtgtca gctcaccgat ttcatctaag aaaatactgc 2243881 cgttatttgc ttcctcaaat aaaccctttt taccgccgcg cttcgctcct gaaaacgcac 2243941 catcctcata gccgaacaat tctgattcga gcaggttttc agaaagggct gcacaattca 2244001 cgcgaataaa tttattgtat ttccggtcac tttcgttatg gatggcatgg gcgaacagtt 2244061 cttttcctgt tcctgattcc ccgcgcagca agatggttgc cggtgttttc gcaccgagct 2244121 tcgcctgctc aagcgcaacc agcatttgct cgcttttgcc gataatgtcg tcaaacgtgt 2244181 atttcgcttc aagcgtgcga ataatttgtc tggcgcgatt aagctccgct gtcagcattt 2244241 taatttcgga aacatcgtga atcacgccga cgctgccttt caaaatcccg tccacaatca 2244301 ccggtgctac attaacgatc acttcttttt cattcgggcc gaccttcatt ctgacaccgc 2244361 ggacaggacg tcttgtttca agcaccttta aatgcatgct ttcgccttcg gaaatatcag 2244421 tgtttgcagg cttgccgatg acttcttttt cagaaagccc cgtcattttc gtatacgctt 2244481 tattgattag caggccgatg ccgttttcat caacgacaga aatcgcctca tcggaggatt 2244541 gaataattgc ctccagcatc gtacggacct gctttaagtt ggtcacttcc tctgccagct 2244601 cgaccgcatc agtgatatct ttaaacacac aaagagcccc gagcagacgt ccgccttcat 2244661 caataatcgg cagtcttgtg gtcacaattt gcaaatgatc gcctaacagc tgcttctggt 2244721 tgtattcagg cactcttgtt tttaaaatcc gcggcatctt agtgctcgga atcacttctt 2244781 ttattgggcg cccaatgact tcctcacgtt tttttccgac cattttttcg gccatatggt 2244841 taaagagaat gatttcttca ttgatatcaa taaaaatcat tccatcatgg gtggaattaa 2244901 aaattctgtc atatttatag gtttgctctt ttagcatttg aatcaggtgc tgcttttctt 2244961 ccatcagctg aaaaacgatg tatgccattt ttcccggcat gacaatggta tcttcatgct 2245021 ttctttgaag gagctcgtca aacacggctt gatcgccggt agtatgaatg acgatatccg 2245081 gtttttgttg tatgtaaggt ttccaatcag atgatacggc aatcccatac tgttctgctt 2245141 ctttcaatcc cggcgcctcg gggtctttgt caactacggc aatgatatct atgatggctg 2245201 ttttaatcag aatatgtaat aacgccgttc cccttttgcc ggcacctact atcagtacct 2245261 tttgcatccc gatacccctt tgtatgaaaa aatttgcaca cctatttatt ccgttgcaat 2245321 aatttgcaca accctatgtt accacgtttt cttctcttga caaaatattt tttccgctgg 2245381 acaataaagg aaatgaaaag ataaaggggt tttctgaaga tgagccgact tcttgcgctt 2245441 ttaatattag tcatccccgg ggctatttct gctttaggca ttaaactgat gagagataca 2245501 cttttcggcc atacaatcaa gccattttca gctctttggc tccaagggtt gtcaggattc 2245561 atcttttttg cgatcggcct ctatgtgctg gccgggttca ttttatacag agacagaaaa 2245621 cgcaatcaag tcagcccgcg attcagaaaa cgatagctga aaaaaagccg gagaatgctc 2245681 cggctttttt tgttgcatta ttcgtcaggc aaaacggtct tggcaatcgt tttgtctaac 2245741 gcttcatagt cataataaga aatcgtatcg tacagttctt ttcgtgtctg catatcatga 2245801 agtccttctt tttgtgagcc gtgctccttc atcaaaccaa acatccgctc acaagctttt 2245861 gccgccgctc gaagcgaggt gacaggatat atcaccatgt gaaaccccat atcttcgaat 2245921 tcatcggcac gataatatgg cgttttccca aattcagtca tattcgcaag gagcggaacg 2245981 gggatacgct cagcaaactg gcggaattca ttctccgcct gtagcgcttc cgggaaaatt 2246041 gcgtccgctc ccgcctcaat gtaagcctct gaacgtttta ttgcggcatc aagcccttcc 2246101 tgcgccctgg catcagtacg ggcaacaaca ataagggagg gtgccgcttg tttaatggct 2246161 tttatttttt gcgccatttc ctttatcgga actagctgtt tgccatttaa atgtccgcat 2246221 ttttttggga gctgctggtc ttccatttga acggctgcta ccctggcttc aagcatctcc 2246281 cgggctgttc gggcggcatt taagacaccg ccaaatcccg tatcgatatc cacaagcaaa 2246341 ggcagatcag ctgcacgcac aagatctttg gcccgttcag ctatctctgc cgatgtgatg 2246401 atccctaaat caggcagccc cctgctggct gtataggcag caccggacaa ataaatagca 2246461 gaaaaaccgg cttctttcgc aagcaaagcg gccatcccgt catgggcgcc gggaatttga 2246521 agaatgtccg gtgctgacat cagcttgcgg aaacgcccgg caagctcctc ttgtgacgat 2246581 tgcttattga cgatccacga catgaaacaa aatccccctt ttacatgcag aacatgtcta 2246641 cgaattcatt tacgcgcatc gtttgtaatg tctcatagct ggtacagcgc tcataaatgt 2246701 gtttgtgctg tttatcagga aaatgggttt tgagattgtc agaaaacttt tccagcagtt 2246761 tcggcactgc ttcctctctt cgaaaacgat ggccgagggg aaactcacat tccaccattt 2246821 ccgtgctcgt tccatcttta aaatgaacct gaacggcatt tgagatggag cgtttatcag 2246881 gcttcaaata atcctcggta tatgttttat tttcagtcac ttccatttta tcacgaagtt 2246941 tatctattct cggatcattc gctgtttcag cttcataatg ctgtgcggtg atatcaccaa 2247001 aaagcaaacc gattgctgta atgtattgga ggcagtgatc acggtctgcc ggattgtgga 2247061 gcgggccttt tttatcaatg attcggatag ctgattcatg cgttctgatg acaactcggt 2247121 caatctcgtc aatccggttc tttacctgcg ggtgaagaat gacggcggac tccgccgctg 2247181 tctgggcgtg aaattccgca ggataagaca ctttaaataa cacattttcc atgacataag 2247241 cgtcgagcgg acgggcaagc ttgatctctt tcttattgaa taaaacgtct tggaaccccc 2247301 aacccggtgc actcaaggct gtcggataac ccatttcccc ttttaacgac atcagcgcca 2247361 aatgaacacc tctgctcgtt gcatctcctg ccgcccatga tttacgcgag cctgtattcg 2247421 gtgaatggcg gtatgtcctc aatgctgcat tgtcaatcca tgcattcgaa agcgcatttt 2247481 tgatttcttc tcttccgccg cccaaaagct ttgctgcaac agcagttgtc gcaactttga 2247541 caaacagcac atggtcaagg ccaactcgat ttaagctgtt ttctaacgcc agcacacctt 2247601 ggatctcgtg tgctttgatc atcatctcaa gtacgtcgcg taccgttaac ggctcttttc 2247661 cttcagacag cctcactctt gatacataat cagcagcggc aaggattcct cccaagttat 2247721 cggatggatg cccccactcc gccgccagcc acgtatcgtt gtaatcgagc cagcgaatca 2247781 tgcagccaat attaaacgct gccctcacag gatcgagaac atatgacgtt cccggcactt 2247841 tgcttccatt cggcacagtc gttcctggaa caatcgggcc aagcagcttt gtgcattccg 2247901 gataccgtag cgccaagatt ccgcagccca gggtatccag caatacatgc cccgctgttg 2247961 tatacgcttc ggcactagta atctctttct caagcacata gtctgtgatt tcttcgataa 2248021 cacgatccgt tttcggcatt ctaccagctc ctttcatgat tttgtttgat atcgcgggcc 2248081 catgtaactg acacggggac ggaagagccg attattggca tgctgttcga tcacatgggc 2248141 gcataaaccg gacgttctcg cgctgaaaaa gatcggcgta tataaaggaa tcggtatgcc 2248201 gagcatccaa tacactgggg cagcatagta atccaaattc gggtaaagcc ctttttcctt 2248261 ctccatcagc cgctcacccg cttcgcacat ctcatataaa cgatggtcac cggctttatc 2248321 gcataattgc tgcagcgcct ctttcatcat gagtgctctc gggtccattt ttttcatata 2248381 cacccggtgg ccgaagccca tgattttttc ttttcttttc agttttgttt gcaaaagctg 2248441 ctcaaaatca gatgtcgttt ttgcctccaa aagcaaatac atcacagctt cgtttgctcc 2248501 tccgtgaaga ttccctttca gggaagcgac agccccagtc aaagccccat aaagatctga 2248561 atgtgtagat gcaatgaccc tggccgcaaa ggttgaattc ggcatctcat gctcactgta 2248621 caggacgagc gaccggtcaa aaatctgttc ttccaatgaa gacggcaatt tccctgtcat 2248681 catgtagaga aaattcgcac tgtaggatag ggtttgaagc ggaagaatcg gttctttctt 2248741 attaatgatc ctgtagctgg cagcagtgag ggcaggcatt ttcccaagaa gctgataggc 2248801 gcgttctttg tttgcggaag gagaccgatc atcaatttgc cgatcatagc cagcaagtgc 2248861 cgacaggccg gtacgcagac catccattgg atgagtgtcc tcagggagca gctcaagcag 2248921 acggagatga tcagcaggca ggcttgaggc actgtttatt ttacgttcca gcgtttccat 2248981 ttcactttct tctggcagcc tgccctccag caataaatgg acaagctcca gatagctttt 2249041 tgtttcagaa agttctatta aatcatagcc tcttatcaaa atctggctgg actgcgtgtc 2249101 aagataagaa atatgagttt ctgccgcaat cacaccgtcc aaccctggag aataatgctg 2249161 tttctcctcc atatcctcaa cctccgtttt tgcgtttttt gtctatcagg ttccgccaag 2249221 caaatacttg gaaataatca gtctttgaat ctcgttcgtc ccttcataaa tttgcgtcac 2249281 ctttgcatcg cgaagcaggc gctcaactgg ataatccttc atatagccat atcccccata 2249341 aatttgaacg gcgtctaacg ccgcctttac ggctgcatcg gaagcaaatt gtttagccat 2249401 agacgcttct tttccacagt ttaggccgcg gttatgaagg tctgcagcgt ggtagacaag 2249461 atgtcttgcc gcctcagctc tagtcgccat atcagccagc ttaaatgata tgccttgatt 2249521 ggctgcaatc ggccttccaa attgcactcg ctgcttcgca taatcaacgg catgctcaag 2249581 agccgcctct gcaattccga gggcctgtgc cgcaatgccg atccggccga catttaaatt 2249641 cgccatggca atgtgaaagc catccccctc tttgccaagc aaattggctt caggcacttc 2249701 tgcattatca aaaatcagtt ccgtagtatt ggagccataa agccccagct ttctttcttt 2249761 ttttccaacg gtaaaaccgg gtgtgttttt ttcaacaata aaagccgaaa tcccgtgcct 2249821 gccttgatct ggagctgtta aagcaaatgt gatatagata tcagctgctc cgccattcgt 2249881 tatgaatatt ttcgatccgt ttaataggta tttgccgttc tttttgattg ctgttgtgcg 2249941 gaggctcccg gcatccgacc ccgagtgagg ctccgttagt gcaaatgcgc ccaaatggtc 2250001 tcctgacgcg agatttggta tatatttcat cttctgttct tcgttgccga aatacagaat 2250061 cggattcgtg ccgactgagg tatgaacgga gagaatcacg ccgacagccg cgctgattct 2250121 agaaatctca tgaattgcca aaatataaga aacaacgtcc gctccagcac cgccgtattg 2250181 ttccggcacc ggtattccca tcagtccgtg tttacccatt tttttgatca gctgaaaggg 2250241 aaattcgtcc gttttctcca tgatttccgc agcgggagca atttcttttc gtgcaaaatc 2250301 acgcaccatt tttcgcatca tgacttgctc ttgggttaca tgcaactcgg ccacccccgg 2250361 atggaataga cttcaggaag tcttctcctc atagtcataa aaaccgcgtc cgctcttttt 2250421 gccaagccag cctgctttga catacttgcg gagcagcggg caaggacggt atttggaatc 2250481 gccaaggcct gagtgaagga cttccataat tgataaacac gtatccagtc cgataaaatc 2250541 cgctaatgca agcggaccca tcggatgatt catgcccagc ttcatcactt catctattgc 2250601 ctccggcttc gccactccct catacacgca atagatggct tcattaatca ttggaagaag 2250661 cacacggttg gaaacaaacc caggaaaatc attgacttct accgctgttt tccccatctt 2250721 ttccgctaat gccataacat ctaaggccgt ttcttctgat gtagccaagc ctcgaatcac 2250781 ttctaccagc ttcattacag ggacgggatt cataaaatgc atgccaataa cccgttgagg 2250841 ccggtttgtt acagcagcga tttctgtaat aggcaaggaa gatgtattgc tggccaaaat 2250901 cgtatgaggc gggcaaatgc gatcaagtgt tttaaacatc tcagtttttg ccgccatgtt 2250961 ttctgcgata gcctcaatca caatgtccgc atgctctgcc tcctcaagtg tttgagaaat 2251021 cgaaatgcgg ttgattacgc tcttcacttc cgtctcggtc ctttttcctt tctcagcatc 2251081 acgggccagc tgtttcttca gccgtttcaa tcctgcctcc gcggcctctg gattcacatc 2251141 atacatccgc acataaaagc ccgcgtcggc ggctgtttga gcaattccgc tccccatctg 2251201 acctgcgcca gctaccatga tttgtttgat ttccattcaa atcccctttt tcatcatgtt 2251261 ttaatgaacc tgcactaaga cggcgtctcc ctgtgctgcc ccgctgcaaa tagcggcaac 2251321 gcccagaccc cctccccgtc gctttaattc ataaacaagc gtcatgagaa ttctcgcacc 2251381 gctcgcgccg atcgggtggc cgagcgcgat cgcaccgcca ttcacattta ctttttcaag 2251441 atcgaaacct acgatttttt cacatgtcaa aacaactgaa gcaaaagctt catttacttc 2251501 aaacaagtca atatcttgga cagttaaacc attctttttc aggagcttgt taatagcaaa 2251561 ccctggcgct gccgccagct cgtgcgctgg cattcccgta gttgaaaaac caagaattgt 2251621 agccagaggc cgtttgccaa gctcagcagc tttttcctca gacatcagca cgaacgcgcc 2251681 ggctccgtca ttgactccag gagcattgcc ggctgtgata gaaccgtcac ttgcataaat 2251741 cggagcaagt tttgcgagct gatccagact tgtgtcacgg cgaatcgctt catctttatc 2251801 aacaacgttt ggttttcctt ttcgaccgat ccagttgacg ggaacaattt catcctgaaa 2251861 cttcccttca tcggcggcct tagctgccct tgcatgactt ctcaacgccc attcgtcctg 2251921 ctctcttcgt gagattgcat attccttggc agctgtattt ccgtgaacag ccatgtgcac 2251981 ctcgtcaaat gcgcacgtta atccgtcata caccattaag tccctaagct cgccgtcccc 2252041 catccgtgct ccccagcgcc cggcgggaac ggcatacgga atattgctca tgctttccat 2252101 cccccccgca acaagtatgt ccgcatcctg cgcccgaatc atttgatcac ataaagtgac 2252161 agcgcgaagg ccggaagcac agactttatt cagtgtttct gacggcacac tccaaggcat 2252221 tcccgccaga cgggcagctt gacgggaagg tatctgccct gagccggcct ggacaaccat 2252281 gcccatgacg tttccttcta catcatctcc agagactcca gcctgttgca gcgcctcctt 2252341 catcacaatg cccccaagct cagcagcttt cacctctttc aaaactccgc cgaatttgcc 2252401 aaatggagtt cttgcagcac ttacaatgac tgttttcctc atggtttcac ctcattcaga 2252461 agatagacag cgcttacaat ttctagttgt cttctatgaa tgtatgcttt gaaacgggca 2252521 tgaatgaatg aaaaaagaag gctgcgtcaa acagcctcct tctaacaact attcattttt 2252581 cagcaatgcc gaagcctttt ctggaaagtc ggtaaacatg ccgtctgctc ccgcttcaat 2252641 gagacgcttc atatcttccg gacgattgac tgtatacggc cttaccttaa tcaaaccgtt 2252701 cctcattttc ttcagtactt catctgtgac ccctgggctg tttatcttcg ggtgatagcc 2252761 ggaagccgga atagacgcga tatatcgatc tgcctgataa agcacatctg aagttaatac 2252821 tgcccgttcg atatgcggtg caagccgggc gcacagcgcc aagctgtcat gattaaacgt 2252881 ggataggatg actctgtcct ctacattaaa tcgcttcact gcctccagca ctttttcttc 2252941 cattccctca tagcggatca cgctgttttt taattcaatg ttgatgagaa aatccttttt 2253001 taccgcccac gagagcacat cttctagcag cggcactttt atatcgctgt acgcttgatc 2253061 gtgaccagcg gccgcattcg cagtctttac ctcatcatag gctgtatcct tcacgaatcc 2253121 tttaagtgat gtcgtgcgat taagtctttc atcatgaatt acaacaatgc gtccgtcttt 2253181 cgtcagctgt acatcaagct ctatcccatc cgctccggct tcaattcctt tttcaaatgc 2253241 aagcattgta ttttcgggaa attgacctga tgccccccgg tgggcaaaaa tctttgtcat 2253301 cgtttcacct caaaccctaa agttttctcc attatactta ttttgtcggc tccactctag 2253361 gattaaggct gtatcaatct actgatcata ataagaatca atgccattga caatcgcatc 2253421 tgcggccttt tgctggtatt cttcacttcc cagcttgtcc gcgtcagagc tgttcgtgat 2253481 aaacccaagc tccgccaaca cacttggcat ttgtgaatat gtaatgacgt aaaagtctga 2253541 ttctttcacg cccctgtctc tcgtttgtaa ggaagaaacg agctgtgact gaatatcgga 2253601 tgccagacgc cggctgttct ccccttcata atcagattga aaatacgttt ctgttcctga 2253661 agctgaagca acccctgaat tcacatgaat gctgacaaaa aggtcagcct gattggcact 2253721 tgccttagcc actctttcct ccaaggtcag aaaatgatcg tcagaccggg atgcaacagg 2253781 attggctccc tcctctttta gtttgtctgt cacatgctct gagacagcca aattaatatc 2253841 cttttcaaag agcccgtttc cgaccgctcc actgtcttca ccgccgtgtc cggcatcaat 2253901 atacactgtt ttcccttcta tcggctctgc tgcctgtgca caaggcgcga gcgtcaaagc 2253961 caatccgcac agcgccaagc tcctccataa cattctcaac ttactccctc cggtcacgag 2254021 ttctttcgca gctgaatatc ttccagctgt aaagttccat tatccttctt tgtatatttc 2254081 accaggacat gtgtctgatc tggcagtgat tcacattcat cacgtttatc cttcggaact 2254141 tgtatcatgg tttcttctcc attaagagaa accgcaatcg tatgaggatc agccgagcca 2254201 atgtattttc cctcttcggt aaacctcggc actgagtcat ccgcacttgc aacactgcac 2254261 cccgaaagaa agagcgcagt aaacagcaaa agaaccgttt gtttcacatg accacctctt 2254321 cctgatgttt ggcttttatc tttgaccaga atggagaatt tgtaaagaca acgcgaatgc 2254381 aggcgagcaa gttccatgat tttcaaaagg gctatacgac ccgatcattt cctgttgtta 2254441 gaaagataac gagcagattt gtctatgagg atggctctaa ttgaggcgcc aattagaaaa 2254501 aattagcgga aagaagcaac tttttattca ttttaaaaaa tttgagaata gggtgagcaa 2254561 atcgtttgac gggtgggtca gccaagcgta accttttaaa ggatatttac tttattgaaa 2254621 gaagttaaag ccatgaaaaa attcgttctg ctgctggcgg cagctgtcat cacatgctcc 2254681 atcggccacc aaatcagtgg cggctacaaa ggccccgaaa aagagcggcc aaaacatcac 2254741 tctgcactca agatattcag tcggtaaagc agatcaattg cattaatttt tacatatagg 2254801 ctagaatatg tgcgaatcca aacgaaagaa gatgatcaaa tgaatcctaa gtataagcca 2254861 ctttttgaac catttacgtt taaaagcggc gttacaatca acaaccggat cgcagtagca 2254921 ccgatgactc attacgcttc taatgaagac ggtacaatat ctgaagcgga gctcgactac 2254981 atcatccccc gttcaaaaga gatgggaatg gtgattacag cctgcgcaaa tgttacaccg 2255041 gacggaaaag cattccccgg gcagccggcc atccatgacg attccaacat tccaggttta 2255101 aaaaagttag cacaagccat tcaggcacaa ggcgctaaag ctgttgtaca aattcatcac 2255161 ggcggtattg agtgcccgtc tgagctcgtt cctcaacagg atgttgtggg gccaagtgac 2255221 gtgtttgata acggcaaaca aattgctcgc gcattaacag aagaagaagt ggaaaacatt 2255281 gtgaaggcgt ttggagaagc gacaagacgc gccattgaag ccggctttga cggtgtcgaa 2255341 attcacggtg caaacggcta cttaattcag cagttttatt ctccgaaaac caaccagcgc 2255401 acggatcgct ggggaggaag cgatgaaaaa cgattagcct tcccgctcgc tattgtcgat 2255461 gaagtgaaaa aagccgcttc agaacatgcg aagggtgcat tcttagtcgg ctaccgcctg 2255521 tctccggaag aacctgagac accgggattg acaatgactg aaacttatac gcttgttgat 2255581 gctttagggg ataaagaatt ggattatctt catatctcac tgatggacgt gaactcaaaa 2255641 gcgcgccgcg gtgcagatcc gactcgcaca cgcatggact tattgaatga acgtgtcgga 2255701 aacaaagtgc cgctgatcgc cgtcggttcc atccattccg ctgatgacgc gcttgccgtc 2255761 atcgaaaacg gtattccact ggtcgctatg ggacgcgaaa ttctagttga ccctaactgg 2255821 acggtaaaag taaaagaagg ccgtgaaaag caaatcgaaa cagtgatcaa aggcacagat 2255881 aaagaaaaat atcatttgcc tgaaccgcta tggcaagcaa ttgtgaacac acaaggctgg 2255941 gtgccttata aagattaatg tgcaaagact gccgaaacga ttcggcagtc ttttttccct 2256001 ttatataaat agtttgtgta cacatctaaa cagcaaaaga aagagctccc caccaacttc 2256061 gaaaagaaaa tccaggaaaa acccctcacg ctttcttgct tttttctttt tcattcgtac 2256121 gtctcctttt tacatgaata cgccttactt acgattttgc aggagaaagg tttcatttta 2256181 taacggacac atctagggtc gatcatgctt cgtgatccta taagatgtat gaatggacca 2256241 agagtgcagg taataccgcc atttgctttc cttacttttc aaacctatcc tttactatat 2256301 gcggatactt aatattcttc tcccatacta caaatgtccc caaaacaaaa cgcctcctat 2256361 ttatcagcgc aaactaataa ataaaagacg tttgatttaa tgaccactta ataagctcat 2256421 gtttaagaag ccttatgctc taacctcagc ttatccgcaa ccattgcaat gaattcactg 2256481 ttggtaggtt tagcttttgt catgctgaca gtataaccaa acaacgagga aatggaatca 2256541 atgtttcctc tgctccatgc cacttcaatt gcatggcgga tcgctctttc tacacggctt 2256601 gcggttgtgt taaatttttt ggcgatgtcc ggatagagga cttttgtaat gctgccgagc 2256661 aattcgatgt cattgtatac cattgagatt gcttcgcgca gatagagata gcctttaata 2256721 tgggctggga cgccgatttc atggataatg cttgtgatgc tcgcgtcgag atttttcttc 2256781 tttggttcag gctggctgct gcgtataata ctgctttgcg atgatggcgc acgatgcgtc 2256841 acactgctgg catttccgct gacctggcgg atatggccga caaggttttc catatcaaac 2256901 ggtttgagaa taaagtagga cgcgcctaaa tcgacggcct ttttcgtgac atcttcctgc 2256961 ccaaaggctg tcagcataat gacattcggc tgttttttca gatctgattc cctcagcctc 2257021 tctaaaaccg caagtccgtc tagatgcggc ataataatat ctaatacgag cacatcggga 2257081 tctttttctt taaacagcga caggcattcc tgtccgttat aagcaacgcc gatcacttcc 2257141 atgtcttcct gtccttctat atattcactt aacaggctta ccagctctcg attatcatca 2257201 gcaacacaaa ctttaatttt ctccacgttt cttcctcccc aaatgtagtt aacaggattc 2257261 acccttgcta catgtttaca ttcgacaaaa ccgctatata ccctctaaaa aaatcataat 2257321 caccaatatt agtggcatat ctttgttatt ctatgttttt ctctgttttt cgactaaaaa 2257381 tgaaatttga caaacaagga aacgtgaatt tgtcgaaaaa tcttcttttg tatattttac 2257441 cgtatgtatt ctgagaagtg aagagggatc aaaataaaaa aactgccgga aactccggca 2257501 gtcagcttgc tttttctttt ccataaatat cgattcctgc ttctgacagc atccattcaa 2257561 tatgaacacc gtagccgctt gtcgggtcat ttacaaatac atgggtgaca gcaccgatca 2257621 cttttccatt ttgaatgatc gggcttccgc tcatcccctg tacgatgcct cctgtttctt 2257681 tcaacagtct tggatcggta attttcaaca ccattccttt tgtcgcaggg aatttttgcg 2257741 gcgttgtgct gacgatttca atatcgaatt tttctacttt gtcatcatca ataaccgtta 2257801 aaatttcagc cggccctttt ttgacttcgg tagaaaacgc aaccggcaat gcttgatctg 2257861 atatgttgtt ttgaatcggc tgatgcagtg tgccgaaaat cccaaacggg ctgtttctgt 2257921 taatatcccc gatcgttttg cgttctgagg aaaatcgcgc cagtttttct cccggattac 2257981 cgcctgtccc tttttcaatt gatgttacag tggatttaac gatttctcca ttctccacta 2258041 caattggttt ctttgtgtcc atatcggaaa tcacgtggcc aagtgctccg tatttttttg 2258101 ttttcggttc ataaaaggtc atagtgccga tgccagcagc agaatctctg atatataacc 2258161 cgattctgta tttgccttct ccttcatcct tttctgggat cagcttcgtt ttgattttct 2258221 gtttatcacg tttgatcagt aagtctaaag attcaccagt tttcccagcc ttttgaataa 2258281 atggggctac atcattcatt ttttcaattt tctgtccatt catctcaata atgatgtcgc 2258341 ccgcttcaat tcctgccgtt tctcccggag attttttgcc ttcacttgta ttgatttgat 2258401 gaaatccgac gacaagaaca ccgacggaat gaagttttac accgattgat tgtccgccag 2258461 gtataacttt taaatcagga agaacatgca cttttgtttt tttaattgga aatccggcaa 2258521 gatcatatac caattctgac tcacctgatt ttttgcccgt caccttgatt tcatgcggat 2258581 ctttctttac tgtaaacgct tctgaggatt ctgatgtctg agcgtttacc gataaactcg 2258641 tttcaatcgc ttgtgtttgg gtttcaaata ctctcatttg cgttggaatc agtaaatatt 2258701 cttttagcgg tttgcataaa cctacactta ataacgaaac aaggagaatt aaacctactg 2258761 cttttctgat gttatcgggc attcactact tcactctcct cgctcctatc ccacaccttc 2258821 tttatgactt gctgctacat catttaattt tgccttctga cggcttattt ataactgtca 2258881 tatgaagaaa aacattggat atactgatga acgaatggat gtgcacgaaa aaaataagct 2258941 gcgcttctcg cgcagcttac ccagttgttt tgacttgatc cgcttgtttt aaaagttctt 2259001 tcgcatggcg tttcgttaag tcggttactt cgacacctgc aatcatgcgc ccgatttccg 2259061 ctaccttttc ctgcttagag agcggcttga cacgtgtcgt cgttctgccg tcttttaact 2259121 ccttcgcaat ataaagatgc gtatcggcca tggcagccac ctgaggcagg tgtgtaatgc 2259181 acagcacttg tgatcctatt gacaccttat ggatcttctc agcaattgcc tgtgcgaccc 2259241 tgccgcttac accggtatca acctcgtcaa aaatgatcga tgtcacatcc tgttgtgagg 2259301 aaaaaatgct ttttatggca agcatcaccc gtgacagctc tccacctgaa gcgactttcg 2259361 aaagggattt cagcggctcg cctgtattgg ttgaaattaa aaacttcacc aggtcaatcc 2259421 cttgttcagt cagctgaacg ggctggccgt ttacaagcgg cgcctcttca ttgcgtgacg 2259481 ctgttctgac cttaaattcc gtatcaaaag ttgatttttc catgtacagg ctttttaatt 2259541 cccgatgaat ctcatcagcc agctttttcg cccatgtttt tcggatttgt gacacatttg 2259601 ccgcttccac tgcgacatct ttgccgacgg agtcaagctc ctttttcaag ctttgaaggt 2259661 ggctgtccct gttttcaatt tggtcaatct cttcttcaat tttagaagca tattccaaaa 2259721 tgtcttcaac agtggcaccg tattttcgtt tcagctgttt gatttcatta agtcgcgtct 2259781 caatatagtt caggcgttcc ggatcaaatt caagctcatc cagcatattt ctcatctgaa 2259841 atgtggcatc ctcaagcaaa tagtaggagt tcgaaacact ttcagacatt tttttcagcg 2259901 gttcgtttat atcagatata tcttcaagct gcgctgatgc cattccaacc cagtccaatc 2259961 cgccctgctc actgcgaagc gcgttatatg cattttgcag cgactcatat atcttctcaa 2260021 agtttgaaat ttgctggcgc tcttcttgga gctgttcatc ttcgttaagc tcaagctttg 2260081 ccgattcgat ttcttcgagc tgaaattgaa taagatcaag acgatgggcc atttcctgtt 2260141 cgctttcaga aagctgctta agctttttga gcagcttcac ataccgctgg tacccttcct 2260201 gatacgtttt gagcgcgctt tccacttcgg ccccggcaaa cttgtccaaa agctggagat 2260261 gattttcgtc ttccattaac agctggttat cgtgctgccc gtgaatatct aataaaagcc 2260321 tgccgatctc tcttagtgaa gcaatcgtga caagcttgcc attgacacgg caaacgcttt 2260381 tcccgctcgt gctgatatcc cttctcatga cgatcatttc gtctgaaacg tcgattccct 2260441 gctcagcgca tacgcctaaa acaggatggc cgctctccaa cagaaacagc ccttcaagtt 2260501 cggcttttgc ttccccatat ctaacaaatt cagatgatcc gcggcctccg actaaaagag 2260561 aaatggcatc tatgatgatg gatttgccgg ctccggtttc tcctgttaaa accgtaagcc 2260621 cgcgttcaaa agaaaccgtc agttcctcaa taatggcaaa gtttttaatc gatagttcag 2260681 ctaacaaaca gcattacacc tcttatcttt gttagatttt ctgttacagc agttcaagga 2260741 gcctgttttt tacgccttct gtatcttcag gagtccggca aataattaaa atcgtatcat 2260801 ctccgcaaat ggtccccatc atttcatccc agtccaaatt gtccatcagc gccccgattg 2260861 cctgggcatt gcccggcatc gttttcagca caatcatatg gcttgctgag tctattttca 2260921 caaatgcgtc catcaatgcc cgctttagct ttgacagcgg attgaaacgc tggtccgccg 2260981 gaagactgta tttgtaagaa ccattatttg taggcacttt tacaaggtga agttctttaa 2261041 tatcccgtga taccgtggcc tgcgttactt tgtatccatc ctgctttagc atgtcgacca 2261101 attcatcctg cgtttcgatt tcattgcttg taatgatctc tctgatttta atatgcctct 2261161 ggcctttgtt catgtaagca cctctatttc caagcttatc tgttctttta tgttatatga 2261221 ttctctgcac attgtacatg aatgcagaaa aaaggaataa tagcgcccta ttattccggt 2261281 acatctgctt ttttttcttt taacgtctta tgtgcttctt ctacaacgcg catgatctct 2261341 tcttccggca gttcctggcc ttcctgtccc tctcccggcc aatgcaaatg aaggagaaac 2261401 tcaatatttc cgtctcctcc cgtgattgga gaaaatgaca agcctttaca gatatagcct 2261461 tcagcggcag aaaaactgat cattcgcttg agcacatcag catgcacttt aggatctcta 2261521 acaatccctt ttttgccgac ggattcccgt cccgcttcaa actgaggctt aactaaagcc 2261581 atgcagtcgc tgcccggtac gagcaaagtc cttaggacag gcaggatgag ccgcagtgaa 2261641 ataaaggaca catcaattgt ggcaaactcc ggcatgccct ttgtaaagtc tgccggtgtt 2261701 gcataacgaa agttcgtccg ttccatcacg acgacccgtt catcctgtct aagcttccat 2261761 gcaagctgat tatagcctac atccacagcg tatgactgtt tagctccatt ttgcaaagcg 2261821 cagtccgtaa aaccgccggt ggaggagcca atatcaatca taattttatc tttgacagag 2261881 acgggaaatt ccttcaacgc tttttcgagc tttaagccgc ccctgctcac atacctcagc 2261941 gggtttcctt tgacagttaa cggaaggtcg cggtcaattt tttctccagg cttgtccaag 2262001 cggttttcgt ttgaatagac gatccccgcc ataatggctc ttttggcttt ttcacgcgtt 2262061 tccgccagcc ctctttccac taataataca tctaatcgtt ctttctttga cgtcatgatc 2262121 caattccttt gtgtgtcttt ggtggcatca gtaatctaat acgatttgcc acctgctgtt 2262181 ttgtcagtcc aatttcctca agaagcgctg ttacacttcc gtgttcaata aaccgatcag 2262241 gtatacccat tctgtcaatc ggagtatgat attcaccttg atcatgagcg aattctaaaa 2262301 tcgagcttcc gaaaccgcct tctaagaccg cttcttcaat tgttaaaatt ggcaagcctt 2262361 cttttaggat actcttcatc atcttttcat caatcggctt aataaaacgc gcattcacaa 2262421 cgcgcacgga aaggccttct ttctgcagct cttcggctgc ttcaatcgcc atttcgattg 2262481 ttgtgccgaa tgttaagatg acagcatcgt tccctggacg cagcacctcc cacgtaccga 2262541 tcggaatcgt tttcaactgt tcatccattt ttacgccgag tccgtttccg cgcggaaaac 2262601 gcattgctat cgggccttcg tcatagctaa gtgctgtatg aaccatgtgc tggccttcat 2262661 tttcgtcttt cggcatcatt aagaccatgt ttggaatgtg gcgcataaac gcaatatcaa 2262721 acacgccttg atgtgtctct ccatcagcgc caacgagtcc agcacggtca attccaataa 2262781 acacattagc gttttggcgg cagatgtcat gaacaacttg gtcatatgcc ctttgcagga 2262841 aggttgagta aatcgccaaa aacggcttca taccctgcat tgccatagct gcagccattg 2262901 ttgcggcatg ctgttctgcg attcctacgt cgaacatccg gtcagggaat tcctttgcga 2262961 agccttcaag ctttgaaccg acaggcatag ccggcgtaat ggctacaatg cgtccgtcct 2263021 cgcgcgccat tcgctgcaca gttccgctga caagaccgct ccacgaagga gctgcggctt 2263081 tcggctttac aaagtcaccg gtattaattt tatatggtcc ggtaccatgc catgtcccaa 2263141 tcgtatcggt ctcagccggt ttgtacccct tccctttttt cgtaatgacg tgcagaagaa 2263201 cagggccttt cgtttttttg gcgtattgaa gattctcaat cagctcatga taagaatgtc 2263261 cgtccactgg gcccaaatac gtaaaaccga gctcctcgaa aaacattccg gagacgagca 2263321 tgtatttcag gctgtctttg acccgttccg ccgtggcggc aagcttgccc ccaactgccg 2263381 gaatcttttt aaataagtat tcaagctcat ctttgaccca ctggtatttc cccgcagtgc 2263441 ggagccgtcc gagcatagag tgaatggcac cgacgtttgg cgcaatactc atttcattat 2263501 cattaaggat gacaatcatg tcttttttct cgtcgccgat gtggttaagg gcttcgagcg 2263561 ccataccgcc ggtcagcgcg ccgtcaccaa tgatcggaat aatatattca tccgttcctt 2263621 taatatcacg ggcagctgcc attcccatcg cgcctgacag agaagtcgag ctgtgcccgg 2263681 tttcccaaac atcgtgctcg ctttcactcc gctttggaaa tccgcaaagc cctttgtact 2263741 ggcgaagcgt cgcaaattct tttccgcgtc ctgtcagcag cttatggaca tacgactgat 2263801 ggcctacatc ccataaaaat ttgtctttcg ggctgttaaa ttccttatgc agggcaacag 2263861 taagctctac gacacctaag tttgggccga tgtggccgcc ggaagcggat aaacttgtaa 2263921 ttaaaaactg acggatttca tcacttaatt tctctaattc atcaatggac atgtttttta 2263981 aaaacgacgg gtcctgtatt gataaaagat ccaaagcgga tcaactcact ttcagcatga 2264041 atttctgcaa tgatacatgt cttttgcatg ccgagctgac aataatctca gacataaaaa 2264101 aagacaaacg cgcttttcct tttcattttt catataaact gcttacattt taccatacct 2264161 cgtgcagccg cttcaaatta ggatcgtttt agtgatctct tgccgcaatt aaatcacaaa 2264221 gctcatataa aaggtctttt tgaagagaga gtccgccgat caatcgcttc gcctctttta 2264281 tatgaacatc caatttatgt ttggcccctt ccaatgaaag aagcgacggg tatgtcgatt 2264341 tgtcatttgt ggtatccgag ccgacacgtt tgccgatttt ctcttcactg ccttctaaat 2264401 ctaaaatatc gtctctgatt tgaaatccga ttccaatgtg gctgctgaag gtacgcagtg 2264461 tttcaatgtc ttcctcaggc gcatcagcca aaatagcacc ggcgattaca caaaagccaa 2264521 ggagcttggc agttttccgt tcatgaatgg attcgagctc ttcaagcgtg acttgtcggt 2264581 tttccgcttc catatcagct acttgcccac cgaccatgcc ttcggtgcct gccgctgaaa 2264641 tcagttcatt cacaagccgc aggcgctttt ctgctgacac ctcgtctgac acgtgggagg 2264701 taatcagctt aaagctttct gtgagcagcc cgtcacccgc taatactgcc gtcgcttcac 2264761 caaacacttt atggtttgtc ggcttcccgc ggcgcaaatc gtcatcatcc atgcatggaa 2264821 gatcatcatg aattaacgaa tacgtgtgaa tcatttcgac agcacagccc accggaatgc 2264881 cgtctttttc gctttttcca tatgcattta aaacagccag tacaatcaga ggccgcaacc 2264941 gctttccgcc ggcctgtaga gaatatagca tagatttctt taatgagtcc ggcatatcaa 2265001 gcttttctgt atagacagaa agctgatttt caattgtttt tttccggtcc gccagaaagc 2265061 tcgttaattt atttgtcacc ttcgtcttcc tcctgaacac tgaaaggtgc cagttcgccg 2265121 tcttctttta aaatgaagtc catttgcttt tcgacttttt gcagcttttc atggcacatt 2265181 tttgacagag ccatgccttc ttggaaatag ttaatggctt gctctagagg cacatctccc 2265241 tcttcaagct ttgatacaat gctctcaagc cctttcatcg cttcttcaaa tgtcatgttt 2265301 tcattttttt tcacgtctgt catttttctt cccctctctt ttctaatact tcacaggtca 2265361 gcacgccatc cttcagcttg atttcaagcc ggtcctgctc ttctatttga ctgacacttt 2265421 taatgagttt atcttcttta taagccaagc tgtatcctct ttccatcact tgaagaggac 2265481 ttagtgcatt cagcttgcca agaacggttt gaaattggga atgcagctgc ttcatttgga 2265541 tattcatatt ttttctcagc tgatttgttt gttcctggta tcgtgttctc gcttgtttca 2265601 gctgttcatg aggatgcaat gcctctaatc tgtacgtttc acgctccagc tgtctgcttt 2265661 tccgatctaa aagagcggtc agctgtgctt gaaactgctg gtacgcgagg tcaaactgct 2265721 gctctttttg cgcatacaaa cgctttggaa aacgaaaggc ataggacgat tgcagcgttt 2265781 gtatccgttc ttttttctgg ccgagatgct gctgcattgc tcttgtcatt ctgacttccg 2265841 ctgtttttgt ccgttcgatt aaatcagtgg tatgaggcac agcaatctca gctgctcctg 2265901 tcggcgtcgc agctctgata tcggcgacaa aatcactaat cgtaaaatcc gtctcatgtc 2265961 cgactgccga tataatcgga atattggaag caaagatggc gcgtgctaca atttcttcat 2266021 tgaatgccca cagttcttct atcgaaccgc cgcctctccc gacaattaat acgtcgcaaa 2266081 tctctttttc atttgcctct tcaatgcgcg taacgatgga tctgctcgca ttttcacctt 2266141 gtacgagcgc tggaagaaca atgactttta caaggggata tcttcttttt agagttgtaa 2266201 taacgtctct gacagcggca cccgttggag atgtcacaac cccgattgtg gctggaaatg 2266261 cggggatttg ttttttgtag cggtcgtcaa ataaaccttc tccggcaagc ttctttttta 2266321 attcttcgta cgctaaataa agcgctccaa ccccgtcagg ctgcatttct ttggcatata 2266381 attgatagtt tccgctcggt tcatatacgg aaattccgcc tctgaccagc actttcattc 2266441 cgttttcagg tttaaaaggc agacgctcgc tttgtctcgc gaacatcacc gactgcattc 2266501 ttgcgttttc gtcttttaaa gtgaaataaa tatgccctcg tgtgtgtatc tttacattcg 2266561 acaattcgcc tttaatccaa atattttcaa ggtgaggatc tacatcgaat tttcgtttta 2266621 tatactttgt cagcgctgag acggtcacat acgctgcttc acccatgtct aaaaactcct 2266681 ctcctaagca ttcctgcacc ataactaaag aaaacccgcc ctggctttag gagcctgaag 2266741 aagcgggtat cgtgctcata ttcaaggcgg gtaaacattt cgcctgtgaa tatctccaat 2266801 tatctatgat aacgtacgtt tcgcagattt aacagtatta tgcgcaagca tcgtgatggt 2266861 catcggacct actccgcccg gaaccggcgt tatgaaggac gctttttcct ttgccccttc 2266921 aaattcaacg tctccgcaaa gctttccgtt ttccagacgg ttaacgccga cgtcaatgac 2266981 aacagcgccc tctttgatct ggtctgcact gatgaagttg gctctgccga ctgccaccac 2267041 caggatgtcc gcttttttcg tatgttcagt aatattttct gttcttgaat gacagtaagt 2267101 aaccgtcgcg ttttcattta ataaaagctg gccgacaggt ttgccgacaa tgttgcttcg 2267161 gccgactaca acaacctctt taccggaaag gtcaatattg gttttcttca aaagctcaac 2267221 aattccatga ggcgtgcaag gaagaaacgt atcttcgcca agcagcattt tccctacgtt 2267281 taacggatga aaaccgtcta catctttatc aggggagata cgttcgatca ccgctttttc 2267341 agaaatatgg tctgggagcg gaagctgaac gagaatgcca tgaaactcag ggtcttggtt 2267401 atattgatca ataatggaaa gcagttcagc ttctgtgagg ctgctgtcaa attgatcgag 2267461 cttgaaattc attcccattg tttctgccgc ttttttcttt cctcgcacgt aagagtgaga 2267521 agcaggatca tctccaatca aaataaccgc cagtccggga gtgacgcctt gctttttaag 2267581 ctcttctacc tcttttgcca attgttcgcg tttttctcta gccgtttctt ttccgtcgat 2267641 gattgttgca gtcattttct ttcctcctat gattgttcaa tatcagattt aatgttagaa 2267701 agaaccccgt ttacaaactt tgtcgctttg tcatcaccaa accgttttgc cagctcaatc 2267761 gcttcgttca tggagacatt caccggaatg tcttcggcat atgccatttc atatgctgcc 2267821 aggcgcaaaa tcgcacggtc aacattggca atccgatcga gcttccaatt caccagatgc 2267881 ttggagatca tttcatccag ctggtcttgg tgttccaata ccccgtgtac aagctgttca 2267941 aagaaaggat ctgttttttc ttcatccagt gcgtgttcta tggcttcatt cactgcaata 2268001 tcgctgacat caatttgaaa tagtgcctgc aaagcttttt ctcttgctgt tcttcttttc 2268061 attttctttc tcctttgatc ctctttatcc gcttgtcgtt aagccacaaa gagatcataa 2268121 catatttttt tcgtatccgc atattgaaat caaggttttt ttaccctatt accgaatatt 2268181 ttcacacacc ttaatatgat tattcggatt tcacgttcat gaagaaactc ggctatgtaa 2268241 gccggctttc ttcatgcttt gaaataaagg gtaacgtgta aaaaaaccaa agggccgccc 2268301 tccccttggt ttcgtgttaa gccatttaca tttcttcgtc gatttggact tcttgggctt 2268361 ttgtgtcaaa ttgaatgccg acgatgtgaa tattgatctc gttaatcgaa agagacgtca 2268421 tatttaataa ggtttgacga atgttttcct gaacggatgc tgcaactttc ggaatcgaaa 2268481 cgccaaatgt aacgacacag tatacatcga tcgtaattcc gtcatccgcc aggtcgactt 2268541 tgacaccttt gccatgattc actttgccaa agcgctcaac gacgcctgtc gcaaagtttc 2268601 cgcgcatttc ggcaactcca tcaacttctg atgctgcaat gccggcaatg acctcaatga 2268661 cctccggtgc aatctcaacc ttacccaaat gcgtatcttc gtgatccatt ttaagcaagc 2268721 tgttgtcttt cattcaattc acctccgtaa aaattatgag cccattacat catatgtttc 2268781 taaaaatttc gtattaaact ctccgctcac aaatgtttcg tgttcaagca gttttaaatg 2268841 gaaagggatt gttgtctcaa tgccttcgat gacgaattcg ctcaatgcgc gcttcatgcg 2268901 ggcaatcgct tcatctctcg tttttccgta tgtgattacc tttgcaatca tgctgtcata 2268961 gtacggtggg atggaatagc cagggtacgc agctgaatcg acacggacac caagaccgcc 2269021 aggaggcagg tacattttaa tttcaccagg tgacggcatg aaatttttgc ttgggttttc 2269081 tgcgttgatt cggcattcga tggcccagcc ttcaaattca acatcttctt gcttgaggct 2269141 cagttccatt cctgaagcca ctttgatttg ttccttgatc aggtcagttc ccgtcaccat 2269201 ttctgtgact gggtgctcca cctggattct cgtgttcatt tccatgaagt aatagcgctg 2269261 ttcattgtag tcatagataa attcaactgt tccagcacct gtatagccaa ccgctttggc 2269321 agcctttacc gctgcatctc ccatttgctc cctgatttct gaatcaaggg caggagatgg 2269381 tgattcttcc aaaagctttt gcaggcgtct ttggatcgag cagtcgcgtt cgcccaaatg 2269441 gatcgtattt ccgtagttat cagcaagcac ttggatctca acgtggcgaa aatcttctat 2269501 gtatttttcg atgtatacac ctggattccc aaatgcagtt gccgcttcct gctgtgtaat 2269561 cttaatgcca ttaatcagtt cctcttcagt gcgggcaacc ctaattcctt ttccgcctcc 2269621 gcctgcggtg gcttttataa ttacaggata cccaatttca ttagcaagcg aaaccgcttc 2269681 ttccacattt tctataattc cctgtgaacc cggtacgatt ggcacgccgg cctgtttcat 2269741 cgtttcccgc gcaacgtctt ttgttcccat ttttgaaatg gcgtcagcgc tcgggccgac 2269801 aaacgtgaca ttcacttctt cacataattc agcgaaatca gcattttcag ctaaaaatcc 2269861 gtatcccgga tgaatggcgt ccgtgccagt cagctttgca acactcacaa tatttgtaac 2269921 gtttaaatag ctgtcttttg atgctttcgg tccgatacaa aaagcttcat cggccatttg 2269981 aacatgaagg gcatctttat cagcttctga ataaacagcg acagtctcaa ttccgagctc 2270041 tctgcaggct ctgatgattc tgacagcaat ttctcctctg ttggcgatca atagcttttt 2270101 aatcatgttc agtctcctta ctccgctttt acaagaaata gaggttgtcc gtattcgacc 2270161 agctggccgt tttctactaa tacttcaacg atttcgcctt tcacttctgc ttcgatttcg 2270221 ttgaaaagct tcatcgcttc tacaatgcag acaactgtgt tttcatttac ttttgaaccg 2270281 gctgttacat acgggccagc ttccggtgat gaagaagcat aaaatgttcc taccattggt 2270341 gaagtgattt tatgcagatt ctcatcttgc tttggtgctt cttgggcagg tgccgctgct 2270401 tgctgcgctt gcggctgaac tgcctgcgga gcctgtgctt gtacaggtgc tgccggtgcc 2270461 tgctgcatga cttgaaccgt gcctgcttcg tgttttttca gttttaagga tacaccttca 2270521 ttttcatata cgaattcgtc aattgtagac tcgtcaattg ctttaatcag ctcgtggatt 2270581 tctttgatat ttaacattca atcgcactcc tatgtatgaa atttcttttt ttataggtta 2270641 ctactaaaag tacatactat gttcatctta caggagcgga cttttgaatt caactctaat 2270701 atgacagcaa cgcaaaaagc ccgcttgttt agcgggcttt tttccctcat tcttatttag 2270761 agggttcaaa tgtgacagcg acatctttca ttgttttgat ttcttttgcc acaaggtcta 2270821 taatggctgt cgccttcgat ttagagtgtt tgtctgattt gactgtaata ttgattttat 2270881 ctccttcagc attaacaagc gcatcctcgt aaccttgtgt tttaatcagc gtttccagct 2270941 gtttttctgt tccttccact tcactgagag ccgtcatttt atcgtatgct tcgcttttct 2271001 ccttggctgt tgcatcatcg cttgacacaa tggcattcag ctcttctctt tctttgcttc 2271061 tggcatcttc taaatcaaga cggtacgttg taaacaaatc atcatcggct gtttccgtaa 2271121 caacagttcc tttttcactg gcttcagcgg atgtttcctt gtctgctgat gaatctttcg 2271181 ttccctttgt tccatcttct tttccttttt cagtttctgt accgcttttt tccttcgtgt 2271241 cttgcttggc aggcgctttt tcagttgcga cctctccgct gtcagacgcg cttttttcac 2271301 tttgcatctg cacggcgttt ttgctttccg gcgacatgat atagtagacg cttaacacca 2271361 cgacaagact gagcattgtt aatagccaaa cggtttgttt tttaagcatt tatgaatcct 2271421 cctttatttt tttaggggca accgcaaccc ggtggcttgg aacatccagg acccgtgtca 2271481 ccgcttcgat aatggtttgt tttatttgaa cgttgtccac tccttgagca acaacgagta 2271541 caccgcgtat atcaggtttt ttcgtttgga cgacgacagg tgtttcttta tcgccgtttt 2271601 tgatcatgac gatttcttcc tccgatgatt ggtctgtaac gcttcttttt ccgccttctt 2271661 tgtcagtttc ttcagtggtt gtatttttgt ttgatttgtt tttttcgtat actttcagcg 2271721 acgttgcatc tacattcacg acaaccgaga catcgtccac accaatgatt gtttcaagaa 2271781 tttctttcag ttgattttcg tattcttttt catagtcatc gatcgagtct ttaggtttat 2271841 cagattttga ggctttaaac acttcggctg ttttctcttt gctgtctgcg gaatgttgtg 2271901 atgatacggc cgttatcgtt ttggcgtttt cagttttctc aggtgaagaa aacagctggc 2271961 tgacaagcat aaaggaaact ccgagaacaa aaacgaatag aaagtaatga tatttggtca 2272021 gcttcggctt ttcgccgtcc ttcgtttgtc ccggaagaaa ctgctttttc aatacattcc 2272081 ataatccgtt tttattcatt gccgacactc tccccgcctt ccatatgaac cgtaattttc 2272141 tcacttccga tttcccaaat gtccgcgagc tgcgtttgta tctgtttggc ttctttttgt 2272201 tcggctgctt cttttgttac gtatgcatga tctgtatcaa tgtggaccgg cgcgaccgtt 2272261 tggaccgttt tttcagaaga cggggccata tacacgctga ttgttttaat atcctcttct 2272321 gaatctacct tttctcctgc cgtgagtttg atgcggccta ctttatattc atcatgactg 2272381 aatctctcct ccgctttctt ttttagttgg acagccattt cttctagaat atatgcgcgc 2272441 tgggaagctt gtatttctat tttttttgaa ttgatttgat tttttatgtc ggcagactct 2272501 gactgcccgt tttttgtgag gtattcaaag atgacttcgg ggtctgtctt gaaaagttta 2272561 aaaatcggcg taagcatgac gacaatcaag agcaggctga ctaccatttt tgcgtacttt 2272621 tgcatgctgg agctcggcag cagcatatca atcacaattg caaataggat aaacaacacg 2272681 atggtggtaa gccattccgt taaaaaactc atttgcctgc ctccttcatt tcatcatcat 2272741 cgtgaggttt ccggctgtga ttatgacagt aaggcttaaa aaaaacatga gagacacaat 2272801 ggcgagagct gcaaaaatat aaatgacgct tttgctgatg acgtcgaggc aggtgatgac 2272861 gggcccgcct cctagcggct gaagaatcgc ggctgccagc ttataaataa aagcgaggga 2272921 aagcactttg attgccggaa atgccgcaat acagatcaaa atagcgacac cgagaatccc 2272981 taccgtattt ttcagcagta aagaggcgct gattactgta tctgttgcgt ctgtaaacat 2273041 tcggccaagc acaggaataa aatttccggt tataaattta gccgtcctga gcgtaatgcc 2273101 gtctgtcact gcagctgacg ctccctgaac agagatgacg ccgagaaaga tggtaagaaa 2273161 aacagccagt gctccgatgg cgatatttct gagcaggtta gccagctgcg ttactttgta 2273221 ttgttcagtc atcgtgctga caatgctcag aatcgctgat aaaaaaatca gcggcatgac 2273281 gatattctga atcaagagac cgctcgtgtt catcaggaag aggataacag gatgaaagaa 2273341 ggcagcagat acagctccgc ctgaggaagc caaaagcgcc aagaggagcg gaatgagcgc 2273401 caggataaag ctggtcatcg tctgaatcgc ctcagttgca tagttaattg ccacatgaaa 2273461 gctattaagc gcaaggataa tcagcaccat gtacacaatt gagtaagcga ccttactgac 2273521 ggtgctttgc tgaaaagcat tttgcaaaag ctgcagaatg acgcaaaaaa tcgtgagcaa 2273581 aatcaatgtg cccagcagct ttccgttggc aagcacttca tgaaacaaat aagaaaagag 2273641 agctttcagc cattcttgcg gtgagaatga tttatcgcca ttgataaact ccattaagct 2273701 gcctttttgg ctttccggca gcagtccgcc gtattctgtc ataatgtcat tccaaaattc 2273761 cccgatctta tctgtttcaa gcgaggctgc tgtcctttcc gctaattgct cggctgtttc 2273821 agcatggtct tccgtttgtt ctgcattacc agctgcttgt acaatttctg cacggcctgc 2273881 tatgatcagc acggccaaaa gcaaaaccca ttgaaagcgc ttcaatctac cgcctccttt 2273941 cggttatgac atagaaggta taagtccgag aatcgtttcg ataatgacgg ttaaaatagg 2274001 cacagccatt acgagtatta aaattttccc cgccaattct attttcgagg cgatggctcc 2274061 ttgaccggca tcttttgtga gctgtgcccc gaattcagca atataggcga ttccgataat 2274121 ctttaaaatg gtttcaacat agaccatgtt gacatttgca ttaatcgcaa ttttttctat 2274181 cattcgaata atgtcgtaga tttggtctac caaataaaga aaaatggcac atccggcaaa 2274241 aacgacgatt aaaaacgcaa aagtcggctt ttgttctttt acaattaaag aaaggaaggt 2274301 ggcgatcagc cctaaaccta caatttgaac aatgtcaatc tgcaagcccc cctatccttg 2274361 gaataaaaac acagctttta tctttttaaa taggtcatct acaatcgtgg cgaccataaa 2274421 taaaatatag ataaaaccta acagcgtcac ccactgagca tattctttct tgcccatctg 2274481 atccaatatc gtgtgtaaaa aagcgaccac gattcccact ccggcgattt gaaatatgac 2274541 attcacgtct actcccattt tatttttgct cccctcacgt ttacatcaat agaagaatga 2274601 gtaacaagcc cgctaaaaag cccaaacttt ttatcatctt ttcgtttttc gcttgcgcct 2274661 gctcagcatc cgcttctgag gcttccaaat gtgtcagcgc cagcttgatg tgcttttgct 2274721 gagagattcg atcatgaatc ccaagcgtct cgccaaactg cttcagcact tcgtattcgc 2274781 tttttttcaa agacagggtg tcccatacct tctttaagct ttgctcccac gccgttttcg 2274841 cggaatcact tcccttgtcc agctgatcac tgaatgcgga aaaaagagtt gaaacaggct 2274901 gtgcgagctg tttggcaatc tgctgtgaag cagtatgaag cggtgtatgg ccgtacatga 2274961 tttcagcctc gagggattga agcgccgcac gcagctggcg gatttgccgc ggccgttctg 2275021 tataaatctt cgccatctca aaacctgtcc atgttgtcgc taccacaatg aatacagcgc 2275081 ccagcagctt cagcatgttt tcacgcccgt cgtcctagac agcacatttc cgtctttgtc 2275141 ataaatttgg ctcactgtgc ccggcccttt tgctcttgat aattccaaat agcggtcaaa 2275201 ggctctttct tcccacaaac gcttcaatga aggccgcttc atcaggtcgg atatactcca 2275261 gccatgcgcc gatacgatta ctgaaacacc ggcatgcagc gcctccagaa gtgcatctgt 2275321 atcttccata cgcccgattt catcgacaat catcacctca gggctcatgg atcgaatcat 2275381 catcatcagc ccttcagctt ttggacaggc gtctaacacg tcaattctct gaccaaattg 2275441 atgctgcgga ataccgcgaa gacatccggc aatctctgac cgttcatcga cgatccctgt 2275501 ctttacgggc agcatgtttt ttttgccggt gcttgagagc ctcgcaaggt cccggagaag 2275561 tgttgttttg ccggtttggg gcggtccgat aatcagcgta ttcagccagc tgttttgata 2275621 taagtatgga agcagcggct ccgcaatccc cagcttttgc cgggcaattc gtatattaaa 2275681 agatgcgatg tcacggaggc ctttcacacc tccgttttcc gtaatgactc tgcccgccag 2275741 tccgactctg tggccgcctc tgatcgtgac ataccctttc ttcagctctt cttcaagtgt 2275801 atacatacta tagttgctga gccggctcag gatcagatgg gcatcctcgg ccgtgcccgc 2275861 ataggacaaa taaacaggtt gtcctcttcg aatcaattca acagggcggt tgatccgaat 2275921 tctgacttct tcgatttcca gccattgttg ttccggtatt tcagaaaggg cgtttttcat 2275981 ggattcaggg agaacctcag cgatttcatt caacagagcc tcctcctttc taccgattgg 2276041 cttctttaaa atgtatgatg tgaggcagac tttatgacaa gcctctcttt atttatgaac 2276101 acccgccaaa atcaagacaa cacccgtaaa aatcagaatc agctttgcat acgaaagctg 2276161 cccggcaatt tggtagattc cgacagtcat tgtaatgata aaaatcaacg gaccgacaat 2276221 agcgagaatg ctgttaacca caaccgcctt ccggacatcg ttggtcacaa gcatgacaat 2276281 tgctgccgtc agctcaatca tagaggataa aactcgtaat cccgccattg ttaaaacagt 2276341 agaattgata tttccaagta aaaatttcat agcactctcc caacctccca tttttttata 2276401 tgatatgctc tagcttgctg aagtagtctt gtcattttcg tataaaagaa agattctgtt 2276461 tttgggcaca aaaaaagcct gctcccattt gggaacagac ttcttttttt ctttctatgc 2276521 tcttgaaacg taagaaccgt ctgatgtatt gacaacaagt gtgtcgcctt cattcacaaa 2276581 gaacggcacg tttacaacaa gcccggtttc agttttcgca ggttttgtac cgcctgacgc 2276641 tgtatcacct ttaataccag gttcagtttc aacaactttc agctcaactg tgtttggaag 2276701 ttcgatacca agtgtttcat cctggtacat catgatatgc acagacatgt tttctagcag 2276761 gtattttaat tcttcttcga tttgagttgc gctcagttca agctgctcat aagaagaagt 2276821 atccataaat acgtgctgat ctccgtttgc atatagatat tgcattgttt tggtttcgat 2276881 ttgcgctttc gctacttttt caccagcgcg gaatgttttt tcctgaatcg cgccagtgcg 2276941 aaggttgcgg agtttagagc ggacaaatgc cgcacctttt ccaggtttta cgtgctggaa 2277001 gtcaacgacg cgccaaatgc cgccatctac ttcaattgtt aatcctgtac ggaaatcgtt 2277061 aactgaaatc atgtttaatg tcctcctata ttccaatcac aaaataataa gttcttttgg 2277121 ggaatgggtg attgtccggt tgccgttttc tgtaatcacg atgtcatctt caatgcggac 2277181 accgcctgtt tctggtatgt aaatgcccgg ctccactgtg accaccatac ccggttcaag 2277241 gatagctgaa gatctgacgg ataatcccgg cgattcatga acttccatgc cgagcccgtg 2277301 cccggttgaa tggccgaaat agtcaccgta gccttttgca gcaatatgat cccttgtgag 2277361 ggcgtcagcc tcttttcctg tcattcccgg cttaatatgt gcgacgccaa gcgcctgagc 2277421 atcaaataca acctgataga tctccttcaa ttgatcactg ggctgaccta cagcgaccgt 2277481 ccgggtaata tcagaacaat atcctttata ataagcgcca aaatcaagcg taacaaggtc 2277541 tccgctttca atcagtttgt cactggccac accgtgcgga aggcttgaac gaaggcctga 2277601 ggcgacaatc atatcaaaag aagagctgtc tgctccctgg cttctcatat aaaactccag 2277661 ctcattggca acagcgattt cagaaatgcc gggtttcata aacgtcaaga tatgtctgaa 2277721 ggcatcatct gcaatcttcg cagcttcctc taatatctta atctcttcac tagacttaat 2277781 caagcgcaac ttttccacgg attcagccac aggcactaat tcggcatcac tgataacggc 2277841 gctgtatgaa gcgtaagtgc catatgtcat gctgttctgt tcaaagccga gacgcttgat 2277901 gccaaacgat tcaacagtgt cggcagtggt ctgaatcaag ctgccgccat gttcaatgat 2277961 ctcaaaaccc tttacctgaa ccttcgcctg ctcagtataa cgaaaatccg taataaacgc 2278021 tgctttgtca cccgatataa cagccaaacc cgccgaacct gtaaaccctg tcatatagcg 2278081 tacattagtg ttgcttgtaa tcagcatgcc gtcaattccc agctgtccaa acaggtttct 2278141 taatttctct agcttcatct tgattctccc ccttgctggc ttaataagta gcgaacagca 2278201 agcttgtagc cttcagctcc aagaccgaca atctgccctt tcgcaacagg agcgataacc 2278261 gactgatgcc tgaattcttc cctggcgtat aagtttgata aatgcacctc taccacagga 2278321 agactgatgc ttgaaacagc atccctgatc gcatagctgt aatgactcag ggcgccgggg 2278381 ttcagaacaa tcccgctgta ttgctcctca gcctcatgta tcgcatctat caaatcacct 2278441 tcgtgattag actggaagaa agtgagctgg atatgtaagg cttcagcaaa ctgaaaaaga 2278501 tctgtttcaa tatcggtcag tgtctggcgg ccgaatactt caggctcacg actcccaagc 2278561 cggttaacat tcggtccgtt caaaatcaaa aaatgaggca cacaatctct ccttttcgcg 2278621 agggtttctc atgtaaaaaa tgttcacttc tcgtgaacat tttatcatac tggaaaagga 2278681 ttatacacta ttctctatgc attcccagcg cacgtgcaag cttttccgaa ttcagctcat 2278741 tgtattcaaa tgaaatagaa tacccgacaa acagcccgta aagcaaataa atgcaaatgg 2278801 tcgtaataat tgtatctgat gtcagttcgg tcaccgtgcg cacatctgga aaaatcggat 2278861 taaaaacaaa aaacacgagc agccaaagca ccaagccgta taaaataccc ggccacattg 2278921 tttttaaacg tttcaataga agaaaataaa gaaatgctgc gccaattgaa attactccaa 2278981 tcaaaatgat gctgattacc gttcccagcc catgtttttt ccactctccg agtacaaacg 2279041 gctgcaatat catattcggg ctgatttcgg aaaaatgaaa caaatatgcg atataagcaa 2279101 cgaaactcca aagtacgcct ccgcaaaaac ctgttgccgc caccctgccg gccattgaaa 2279161 caggcggctt ttgcttctca ttcaattctt cattttgttc tgtatctttt tcgcttgtca 2279221 tcatggcacc tccagttaaa gtgtgcccaa aaaatgaaat gtcaataaaa aagctcacac 2279281 tttttggcag ctgcgagtaa aatttgaaaa taacgggtat aatgcatgta gaaaaagcaa 2279341 ggctatggca attttttcag cctgtcaatc tagaggttta gcgctgtttc ctgtacaata 2279401 gagtgaaagg aaatggttag caatcctaaa gaaataggca ggttgataat atgtcaaaac 2279461 ataaagttcc gcccgcttac ggcgggcagg ctgttgtgga aggcgttatg tttggcggaa 2279521 agcatcatta cgttacagcc atcagaagaa cggatggaag cattgacttt tttaagcttc 2279581 cacgcaaaca caacccgaaa ctgaacatcg tgaaaaagat accgttttta cgggggatcg 2279641 cggccattat cgaagcgagt gcaaacggca caaagcattt gaatttttca agcgaacgtt 2279701 acgggctcga tccatctgaa gacgagacac ttgagcagga agaaaaaaaa tcctctgggc 2279761 tgtctatgta tctcagcctc gcagttatag gcgtcctatc atttttgttc agtaaattcg 2279821 tatttacatt ggttccagtt ttcttagcgg aactgacaag gccgattttt tccttgaaca 2279881 cagcgcaaat cgcgattgaa agcctgttta agttgatttt gctgctcggt tacatctatt 2279941 ttttgtccat gacaccgctt attaaaagag tgtttcaata tcatggagcc gaacataaag 2280001 tcataaactg ttatgaacag aatttgccaa ttactgtgga gaatgtccaa aaccaatctc 2280061 ggcttcatta ccgctgcgga tcaagcttta ttttatttac gattattgtc ggcatgtttg 2280121 tttatttact cgttccgaca gatccgcttt ggctgcgtgt tatagatcgt gtcgcactga 2280181 taccggtcgt gcttggtata tcctttgaag ttctgcagct gacaaacaaa gtgcgtgaca 2280241 ttcccggtct gaaattactt gggtacccgg gactttggct tcagctgtta accacaaagg 2280301 aacctaagga tgaacaggtt gaagttgcca tcgaaagctt taacgaactt ctcagactcg 2280361 aagcattgtc tgagcaaaat cagaagcctt ctcacaacgt catctaaaat ccgttgccct 2280421 gctattactt tcggaggtgg acagttatga atcatcgtgt acaacctatt attgctgtat 2280481 taattgcgct gggagcgttc ggtttcctct atgtgctggt aaccaatccc ggagaaatgg 2280541 caaaaatggc ggtaaccgtc atcgtggcag gtatcattat ttattttatt gtgaaatatg 2280601 taatgaatcg aaatgcgggc agcgaaggag cagccttcaa aaaagcggcg aaacaatcac 2280661 ggcgccggat gaaagaacaa aaagcaaaac accgcgccgg acataaggga cgtgtcagcc 2280721 acctgcgaag cgttccgagc gccagcaagc ctaagccgat gattctcaag aaaaaaagcc 2280781 agactcagct gactgttata gaagggaaaa aaaataaaaa gaaaaacaga gcgctttttt 2280841 aataggtcca ctgctttaaa aacagctctg tccgtctttt acctagctca atcagggcta 2280901 gttttttttg ttgtgttaaa tgaaaatcag tggccattac gtcatcaaca gggagaaaaa 2280961 tgatattttg ttcatagcgt gacgcaatgt gccttgcgtc atgagcatcc ttcatcgttt 2281021 caaacagggc gccgaacagt tcaaaagcgt tgcggatatt ttttttcgga cgctctcttt 2281081 cacgcggcgc aagcgtgaca ccgatcacag ggcgctttct ttcctttgaa aacagccaga 2281141 ttggaaaatt gcttaacacg cctccgtcga caaccgtggc ggtgcctgtg tccgttttta 2281201 attttatcgg ttcaaagaaa tacggaatgc tgcagctcat tctgaccgct ctggcaaccg 2281261 ggaacatatc tggatttaac ccgtaacggg ccaaatcgtc cggcaaaaca atcatggtgc 2281321 cgtttgtcag atcagaagca ataaggcgca gagacccttt ctgcaaatcg ccgaaaaccc 2281381 ttatgccttt cgctcttaac agatcagcaa tccatttttc tatcgtatcg cctttgtata 2281441 agccaagacg ccagtagatg gacacccact ggagcatctt taaggggaga aatgagtacc 2281501 tctgatccag caatttctct ccgtccactt cttcaattaa agcgtggatt tccttactgg 2281561 tgtaacctga cgcaatgaaa gcggcaataa tggcgccggc gcttgtaccc gcaactcttt 2281621 taaagcggaa gcctttttcc tcaagcactt cataagcgcc tgcgagcgca atgcctttta 2281681 ctcctccgcc ggaaaacaca ccgtcaatat acatctcatt ccctccccct ccatccgatc 2281741 gtttattacc attttaagaa aacacgcgaa gaaatagacc aacgaatgac gggtggcgtc 2281801 agcgtatcaa aaaagacggc ctccttcgag accgcctttt tactgattat gatgttctgt 2281861 tttcttttgg attgatttca gatctttttt acgggcatca tcttcttcaa aatattgaac 2281921 aagatccccg atgcgatcaa tactgttcca gcttaaatga tgttcgattc cttcgacatc 2281981 gttatatatt ttctcttcat caacaccaat gattcttaaa aactgctcaa gcaattcatg 2282041 tctgtatacc agccgtttgc ctattttttt ccctttagac gttaacacga gaccgcgata 2282101 tttttcataa attaaatatt cgtctttatc tagtttttga accatttttg ttacagagga 2282161 gggatggact gccaatgctt ccgcgatatc ggaaactcgt gcatatcctt tttcttcaat 2282221 cagcatataa atctgttcaa tataatcttc catacttggt gttgtcatcg aaaccctccc 2282281 aaaaagcacc ttaactttat aaaccattac aagtttacac taatgaactt gaaaaaacaa 2282341 ggatgctccg cgggtcaaaa gccctgttta ccgcttataa ttccattcat ctgaagcgta 2282401 ctttgtttca gccaagtgat gaacaaaatc aagctcttcc tgagaaagtt catatggctc 2282461 caaatgaatg ttaagacctg tttcaaatcc ttctttaaag gctttacgag cctcatccat 2282521 cgtcacccgc ttttcgatga gttcattaat ggcaaccgct ttatttttga aattgcgctg 2282581 catccgctct cttactcttt cacttggata taagaacaga tcgaacagct tgtcctcatc 2282641 taaatcaaga agaatggagc catgctgaag aatcacacct ttttgtctcg tttgcgcgct 2282701 tcccgccacc ttgcgcccct caaccactag ttcataccac gaaggcgcgt caaaacaaac 2282761 agatgaccgc ggatttttta agctttcttt ttctttttca gttctcggga tggcaaagta 2282821 agcgtccaga ccgagatttc taaagccttg aagtatgcct tctgaaataa cccggtaagc 2282881 ctcagtaaca gtcgccggca tctcggggtg ctcttccgaa acaattacgc tgtatgtcag 2282941 ttcctgatcg tgcagcacac ctctcccgcc ggtcgggcgt ctgacgaatc cgagattata 2283001 tttatgtact gcttcaaaat tgatttcctt tttaatattt tgaaaatacc ctacagaaag 2283061 tgtcgccgga ttccagccgt aaaaacggat aaccgggggg attttctttt cgctgtgcca 2283121 atataaaagc gcttcatcaa gcgccatatt gaatgcagga cttgcattgc ctgagtctat 2283181 aaaccgccaa gtttcttttt gcattttaag accttcctta ccgttttaat agaatcagtt 2283241 tatcaaactg tcgggaaaat gaaaaatatt ttagttccat tatagatgac aatcacgctg 2283301 tgctttacta taatagtatt tgtcgaaaac ggctctatga ccttgtttta tgaagcaggg 2283361 ttttgatttt atatgctaaa ggagtagaat cacattgtct aatatgatcg ttttgattat 2283421 ttttgctgca tttatcatct atatgattgc ttcatatgtc tatcagcagc gaattatgaa 2283481 aacacttacc gaagaagaat tccgcgcggg ttaccgcaaa gcgcagctta ttgatgttcg 2283541 tgagccaaat gagtttgagg gcggacatat tttaggcgcc cgcaacatcc cgctttccca 2283601 gctgaaacag agaaaaaatg agatccgtac ggacaagcct gtttacctgt actgccaaaa 2283661 cagtgtccgc agcggacgcg cggcacaaac cctgcgcaaa aacggctgca ctgagattta 2283721 caacctaaaa ggcggcttta aaaaatgggg cggaaagatt aaagcgaaga aataaagcaa 2283781 acagctgtct ggtagacagc tgtttttatt tatctttctt ccgcctcgta tctgagcact 2283841 gggtgtctcg ccgcttttgt ttcatccatt ctttttacaa tcgttgtatg cggggcctcc 2283901 tgaacaagct ccggattctc ctccgcttct tttgcgattt gaatcatagc atcaataaac 2283961 gcgtccagtg tttcctttga ttcggtctct gtcggctcga tcatgatgca ttcttcaaca 2284021 ttaagcggga aataaatcgt cggcggatga tagccgaaat caaggagccg ttttgcaata 2284081 tcaagcgtac gcactcccag ctttttctgc cgcttccctg ataatacaaa ttcatgcttg 2284141 caatggcggt caaacggaag atcgtaataa ggcgcgagtt ttctcatcat ataattggcg 2284201 tttaacactg cgttctcagt aacagccttt aatccgtcag gccccatgga gcgaatatac 2284261 gtatacgctc tcacattaat gccaaagttg ccgtaatacg gcttcacacg gccgatcgca 2284321 tgagggcggt cataatcaaa cgtaaagcgc ccttcttttt tgactaaaac tggctttggc 2284381 aaataaggaa tcagatcttg ttttacgccg acagggcctg agccggggcc tccgccgcca 2284441 tgagggcctg tgaatgtttt atgcaggttg aggtgcacca cgtcaaatcc catatcacca 2284501 ggtctcgcct tgcttaaaac ggcatttaaa ttagcgccgt cataatacag tttccccccc 2284561 gcttggtgta caatttccgc catctctgta atctgctcct caaacaagcc gagcgtgttc 2284621 ggattcgtca gcataagagc tgcagtttct tcattcactg ctctttttaa atcctctaaa 2284681 tcaacaagcc ctttttcatt cgatttcacc gtaacggttt caaagcctgc tactgttgct 2284741 gatgcaggat tcgtcccatg cgcggaatca gggacaatga ccttcgtccg cttgaaatcc 2284801 ccgcgagctt catgataggc acggatcatc atcagccccg tccattcgcc gtgcgctccg 2284861 gcagcaggct gaagcgtaac ctcatccatt cccgttattt cttcaaggtg tttgcttaaa 2284921 tcatataaaa gctctaatgc gccttgcacc gtgtcttcat cctgaagagg atgaatcgca 2284981 gcaaaaccag gaatacgtgc gattttttca ttgattttcg gattatattt catcgtgcaa 2285041 gaaccgagag gataaaaacc ggaatccacc ccgtgattgc gtttggacag cgctgtataa 2285101 tggcgcatga tgtccagctc tgaaacctcc ggcagcgctg cgtcttcgtc acgaatatag 2285161 gtgtctgaca agaggtcccc caattcgatt tccggtacat cgagctccgg cagactatag 2285221 ccgattcggc cttctcttga aagttcaaaa ataagtgcct ggtcctgatt actcatggcg 2285281 atcccccaat tcctgaatga gtgcgtcaat ttcttctttt gttctcagct ctgttacagc 2285341 aatcagcata tggcagtcca gctctggata cgtcaaccca agatcatatc cgccaatcat 2285401 gccttttgcc agcaaacgct tgttcacagc tctcaccggc tcatccagtt tgatgacaaa 2285461 ttcattaaac atcggcccgt caaacataac agtaaggcct gctttttttg cttcttgctt 2285521 tgcatagttg gcttttaaga gattttggcg ggctatatct tttacgccgt tttttccgag 2285581 agcagtcatg gccactgatg ctgccagcgc atttaaagct tggttcgagc atatatttga 2285641 tgttgcttta tcccggcgga tatgctgctc cctggcttgc agggtaagca caaagcctct 2285701 ttttccgttt tcgtcttccg tttgtccgac gagacggccc ggcacctttc tcattaattt 2285761 tttagtaacg gcaaaaaagc cgcaatgcgg gccgccgtat gctgaaggaa tgccgaaagg 2285821 ctgcgcatca ccgacgacga tatcagactg aaacttgccc ggcggagtga gaagacctag 2285881 cgccagcggg ttggctgaaa caataaacat ggatttccct tgatgagcga taggctcaat 2285941 atcctttagc ggctcgatcc tgccgaaaaa attcgggtac tgaacgatca ctgcggctgt 2286001 gttctcgcaa acggtttggc gcaatgcatc aagatccgta acgccatccg cagcgggtac 2286061 ttcaacaaca tcaatatact gaccttttgc gtaagttttc agcacctctc gcgattcagg 2286121 atgcacggtt tttgacacaa caattttttt ctttttcgtg tggcctgaag caagcattgc 2286181 tgcttctgcc aaggctgttc cgccgtcata catcgaggag ttggcgatat ccatgcctgt 2286241 cagttcacag atcatcgttt ggaattcaaa aatagcctgg agctctcctt gtgaaatctc 2286301 tggctgataa ggcgtatatg cggtataaaa ctcagagcgc gaaatgacat gatccacaat 2286361 gacaggctga tagtggtcat atacacccgc tcctaagaaa gaagcgtatt gtacggtatc 2286421 acgattttta gaggccagct ttgtcagttc tcttgttaat tctgtctctg atttcgcttt 2286481 tttgatttga tgctcttttt tatatttgac gttttccggt atatcagcaa ataaatcatc 2286541 gatgctgctt acgccgatag tagcaagcat ctcctgttta tccttttctg ttgcgggcaa 2286601 ataacggtgc ttcatgtgtt gtctcctctc tccaagaaaa aatattagcg tttataaaat 2286661 ggtgttttga caacctttgc tttcactaat tttttgcgta tctctacatc tacaacagtc 2286721 ccgatctcac tcgtttccga atcaattaag gcaaggccga cgttttttcc taatgtcggt 2286781 gactgcgtgc cggttgtcac ctttccgaca gacttgccat tttggaaaac ctcatatccg 2286841 tgccgcggta tccctttttc aatcatttcg agaccgacaa gtttgcgctt cgctccgttt 2286901 tctttttgtt cactcaatac tgacttaccg aaaaagtcag actccttttt gtgctttaca 2286961 gcaaagccta tacctgcttc aatcggtgta atatcccggg tcagctcctg accgtagagc 2287021 gggagcttcg cttcaaaccg gagtgtatca cgtgcaccga gaccgcatgg aatcaatccg 2287081 tatgcatccc ctgcatcgat gatttttttc caaatatgca tagcatcatc actgcggcag 2287141 taaatttcat acccgtcttc tcccgtatag ccagtgcgtg aaataagtgc tttgcggccg 2287201 ctgatatcgg cttcatcaat aaacgcaaac ggctttaatg cagacacatc cgcatctgtc 2287261 agatttttta agatcgcttc tgctttcggt ccctgtacag ccaagagcgc gatttgatct 2287321 gactgattgt caatctgcac atcacctgct gcatgttctt tcatccaagc caagtcttta 2287381 tctatattag aagcattaat gacaagcaga tagcggttct ctcctttttg atagataagc 2287441 aaatcatcga cggttccgcc atccgggtaa cacatcgctg tatattgagc acggcctggc 2287501 gttaacgcgg aaacatcatt tgtcatcaat ctttgcaaaa aagacagact gtcgttccct 2287561 gacacttcga cttctcccat atgagataca tcaaacaaac cggctgcagt tcggacagcc 2287621 tcgtgttctt tttttataga agaaaattga acaggaagct cccagcctcc gaaatcaatc 2287681 gtttttcctc catattcctt atacaggtca aataacggcg ttcttttcag catctaattc 2287741 ctccccttta tcaacggcgc agctaaaaaa catacaaaaa aggacagaga aacacctcat 2287801 gtaaaatgaa ggttctctgt cctggcacct gaaagtttac tttgcatacg caaagacgtc 2287861 ccctttggtg gtttgcgcat ccgcacaaac actctccaga gttgcgtcga gcaagagttc 2287921 ttttgcctga gagattcact ccgcagtttg ctccttcggc gcctgtatcc cgaggttttc 2287981 ggtcaggtct ctccccttgc tgtcattcgc tcatattttc atgctgttat ggacatacta 2288041 tagcaatatc ttacatcaaa tacatactca tatcctacca tcatcactat atgctgggca 2288101 acagcaattt gggcagattt ttcttatatt attcatctta agaatcgaag aataagaaag 2288161 gcggtttcaa agcaatgaat acagaaatga tctacgatgc aaaatggcct gaagaatttg 2288221 ctgaaagact gaaaaacgat ggcccttggg caaactggga actgtacaag ctctctgcag 2288281 aaatccagaa aacattagca attccagagt ttgaaggctt acgggctcct ttatatctgc 2288341 cttcctttac gccgctcccc caccagcttg aagtggcgca aaaagtggtt gaaaaaatga 2288401 acgggaaagc gattttagca gatgaggttg gtctcggaaa aacggttgaa gctggactga 2288461 ttctaaaaga atatatgatt cgcgggttag caaaaaaaat tttgatcctt gtgcccgctt 2288521 cccttgtgtc acagtgggtc aaagagcttc aggaaaaatt tttgattccg gctgttgaac 2288581 aaaagaaaag ctatgtgtgg gagcaatgcg atattgtcgt ctcatcaata gacaccgcga 2288641 agcgctcgcc ccatcgagaa atcgttctgt ctatcccata tgatcttgtc attattgatg 2288701 aggcacacaa actgaaaaat agcaaaacga agaactatga atttgtccgg aatctcgtaa 2288761 aaaaatattg cctgcttctt accgcgacgc caatccagaa ccgtatcgaa gagattttca 2288821 atttggtgtc cttattaaaa cccggccatt taggcagtca gaatcacttt caggaggagt 2288881 tcgccaagaa gaaatccagt ttagaagcgc atgaacattt aaaagatctt gtgaataaag 2288941 tcatgatccg taacaggcgg catgatacag ggctgaattg gaaacagcgc catgttgaaa 2289001 cagtgccgat tcaattttct ccatcagagc aggcgcttta tgatgaaatt tctcgtttga 2289061 aggacagtat caataaacca gccagcatgt tctcgattat gaccttgcaa agagaatgct 2289121 gttcgagcag agaagcggta tatatgacgc tgaaaaagat gcttgatcaa aaagagaaac 2289181 aagcacctgc cattgatgag gatacgattt cagttttgat agatcgcatc aatcaagtga 2289241 cacaaaactc taaagcgctt caagttgttg acttgatcaa aaagatcgac gataaggtca 2289301 tcatttttac agaataccgc gcaacccaga tttatctgca gtggtttctt cagcaaaacg 2289361 gcatcagttc tgtgccgttt agaggcggat ttaaacgtgg aaaaaaagac tggatgaagg 2289421 atcttttccg cggaaaaatc caagtcctta ttgcaactga agcaggcggt gagggaatta 2289481 acctgcaatt ttgcaatcac atgatcaact atgacctgcc atggaacccg atgcggcttg 2289541 agcaaagaat cggaagaatt cacagactcg ggcaggagcg tgacgtgcat atttataaca 2289601 tggcgacaaa acatacggtg gaagagcata ttctaaagct tttatatgaa aaaattcatt 2289661 tgtttgaaaa agtggtcggt gaacttgatg atattttaac gaaaattcaa gtgaacaatt 2289721 ttgaagagca ccttcatgac attttgtatc actcagcaac agaagaagaa atgaaaataa 2289781 aaatggataa cttaacctca tttttgtctt ataaaaaaca gctgcctgct gaaaaaagag 2289841 gatcttagcc tgtaaggagg ttttattagt gagacagcaa gaggttcacg attttctgct 2289901 gcgttttttt caagcaaaca gctgccaaat cgtcgatcaa ggcttaggct atatgacagt 2289961 gcagcttaca gttgaaatgg acaaacaaat catgaaccgc cctttctact ggcattggcg 2290021 cgagaagaca ggcggtgatc cgaatccaat gaaaatcact tttattacag ataaagaaaa 2290081 tgcgccaaaa gacctagatg gtgaatttat atattttggg gccccgcgtc tttttcaaat 2290141 attcaaagct gttaaacaaa atgggagatt taccagaatg tatgagaaaa ttgaatcagc 2290201 cggagctaaa gtcccacttc agccttggct tggtataaat gtcacgattt cataccagtc 2290261 cgacatgaaa aaggataagt tattgtcact aggtcttcac ctagtctctg gaacgataat 2290321 tgaagatttt caaagcaagc tgacccagtt ttcactgacg tctcaaatat gtgactattg 2290381 cttcaccatt tcacctatga tcaaaccaga aagcggactt aagcgtatgg aaaactatat 2290441 ttccaaatcc gctatgcagg agccgtccga ctgggcggaa caggcggtta acaggtggaa 2290501 gaatgatatg acattgcttg ataagtttta cgagcatata gaagaaaaac cagaagaata 2290561 ccatctagaa aaacaggcgc tgaaaacctt gtatcaacca aagatatcag ttgaaattga 2290621 aaatggcgga ttgttttatc tgcaaaataa tatttcaagc taactttttt accattcgac 2290681 atcattctcg ttttttttga gaaaatacga ttataataaa ggtatattgg aaaaaaattc 2290741 tggtgattta atggcaaatg acttccagag actaatgaag catacaataa gtcatggccg 2290801 gactggctga aatacataaa caagtatttt aggaggagaa actgcatgaa gaatgcaaaa 2290861 caagagcact ttgaattgga tcaagaatgg gttgaattaa tggtggaagc caaagaggca 2290921 aatatcagcc cggaagaaat acgaaaatat ttacttttaa acaaaaagtc tgctcatcct 2290981 ggtccggcag ccagaagtca taccgtaaat cctttctgaa tgtgctataa tatcacaagg 2291041 aaggtgatga cattgattgg ccagcgtatt aaacaatacc gtaaagaaaa aggctactca 2291101 ctatcagaac tagctgaaaa agctggggta gcgaagtctt atttaagctc aatagaacga 2291161 aatctacaaa cgaacccctc cattcaattt ctcgaaaaag tctccgctgt tctggacgtc 2291221 tcggttcata ctttgctcga tgagaaacat gaaaccgaat acgatggtca attagatagt 2291281 gaatgggaga aattggttcg cgatgcgatg acatccgggg tatcgaaaaa acaatttcgt 2291341 gaatttttag attatcaaaa atggagaaaa tcccaaaaag aggagtagtg cctgagcaga 2291401 ggcactaact cctcttttgt caataaccat cgagacggcc cagtatatga atactgggcc 2291461 gtctcttttt tttgctgtta ttaattttta tcctcgctat gcgctttttc attttctttc 2291521 acgtaaccat ctttatcagt atggtccttt ttgattgtca agccgttcca ctgtgtagct 2291581 tcgaatgaga attgaagctt aatggagttg ccttgatatt tattttgaac cataagccct 2291641 ttttcatctt ttgttttatc atccttgaat tggatttcca tttgaacctg atcgaagtca 2291701 gttggtgttt ttggaacacc atcatattca ggagcggttt taccatcaat tgttgctaca 2291761 ttgactttac cgcttgcatt taagaattta gggtcaattt gttttttgat tttttcagca 2291821 gccgctgcat catttttagc agacatcaaa tacaagtctt taaggttcgc atcatctaaa 2291881 ataatgtttt tcgggtagcc attgccgccc tcttttccaa ctgtcaacaa tgtcacttca 2291941 aactggctga ggaaatcttc tggagatgta ttgctgccgc cgtttgcttt aaaatctcca 2292001 taattaagcg ccattagaac ttctttgatc gcaagtgatc cgttattttc aaattggaaa 2292061 tcctttgtca acttatctcc cggctttaga tttgataagt tcacactcgc tgaattctct 2292121 ttagcagata aatcaagcgt acctgatgca aaagtagcat cctttgattt aatgtcgtta 2292181 aatgctgccc atgttcctcc tccaactaaa gctaatccta gtgctgcaga agcaactcct 2292241 aaactcaatt tctttttcat acccatggta agctcccctt ttattgaatg attttatatc 2292301 gaaacctgtt gccaggttta caactgaagt taagtagaca tggtgctgtc ctttgtatct 2292361 gtttccaagg cttttgtctt tctttcaatt tctctaatgg cgctgctgat cgtcacaaaa 2292421 gcgtaaacta acagcatcac gccgggaaca atcaataata cagccgttcc aatcggctgg 2292481 ctggcaaaat gaagcatata gccggcatat ggaagctgaa aacctgtgta ttgcgcgcga 2292541 acattttcgt ccgatacagg cgctgaatca gctgctgcat tattatcacc ttttgtttta 2292601 aataacaaat ggtctccttg ctttgttatg tcaacaattc tgtgggtgac cgccgtattt 2292661 gcatcctgca taaatgtaat aacgtcacct ttttggagct ctttcacatc agtgatttct 2292721 ttgaccaata ttaaggaacc tgtattgaac tccggctcca tcgaacctga cagaactgat 2292781 ttcagcgtat acccaaacac tgccggctct cccccggatg aacgtgttga aatcacgaca 2292841 agtgtcagca caataataag agtaaagatg atcacgtata aaatattact gatcagcttc 2292901 attgcttttt tcatcctctt ccccgctttc cttctggtct gattgagttt ctttttcttt 2292961 ggttacagct tcttgagatg tttcttcttt cattgttttt tccggtatat ctttttgtgt 2293021 tgtttcattc tcctttttga cgtccgactt tgtttctttt ttagggactg tcggtttttc 2293081 atcgcatttt gcaagcctca taggctccga ccactcaaat gtactgccgt ttgccgggta 2293141 gcctgccggt ttatatactt taaatgcata aatgccgggt ttcatttttt tcttggtctc 2293201 aattttataa agtgaatcgc cgatttgatt ggagacaaat cctttttcga tcacgttccc 2293261 atcctttaac ggtttgcggg cattttcaag cttatgaagc tcccacttcc actttgattt 2293321 cttaagtttc tcacctgtat tttcgagcac agcaaataag gcgaaaggtg agcatacagt 2293381 gcctttcgta tccgtttgat ctgatatgtg caaatcactt tgatcccagc gtttatcata 2293441 atggcagttt ttatctgtat gctgaaagtc tttacacgtt tgaagtgaga catcaaatgt 2293501 ttcaatatca tgaaaagcag cgcttgtatc atcggaaaat tgtaagcata ttgcggcagt 2293561 cagactgaaa atgactgaaa gctgaaagat aagcagaact ttcagtttcg tcttcgcctt 2293621 ttgctgattg tgaaacaatc gaaacatatc ttacctcctg taaaacactg taacttgata 2293681 tgacaatcgt tctctttaaa gaacttcaca aatagagtat aatcaacgat ttatagattt 2293741 aaaaacaccg aaatcgctca ttttgttcgt ttaaaagaat gttttcatca tattacaaag 2293801 tcttgctcag tattgctcat tttttcaatt ttttagaaat ttttgggatt gttatgtgag 2293861 aatttaaatg catatcccat tattatttgg taataataaa caaagaaagg gtgacagcat 2293921 gatgatcaaa caatgtgtga tttgtctatc tcttctcgtc tttggcacca cagccgctca 2293981 cgcagaagaa acaccgcttg taaccgcccg ccacatgtcc aaatgggaag agattgctgt 2294041 aaaagaagca aaaaaaaggt acccgctcgc acaggtactg ttcaaacaaa aagtatggga 2294101 ccgtaaaaga aaagatgaag cagtgaagca ataccattta actctgaggg aagggtcaaa 2294161 agaattcggc gtttttgtga cgatttcatt tgatccttat agccaaaagg tcaataaaat 2294221 tgccatatta gaagaatatc aataaggtcc tccatttttt gaaggacctt attcgtttat 2294281 ttgcggttat tttttccgtt tcagccaaag tcggaagcca tagggtaaaa taccgaacca 2294341 ctgctgggaa acaggcgttt ttgtttcttt ccgcacctct tttcgttctt ttcgctcatc 2294401 tctcggagta tctatatatt tgacaaattg ctgcgtcata tatttaacat aatcattcgt 2294461 tttcacgtga tcacctcatc attcaattat tatgagtgtt gtctcacatg acttttttta 2294521 taccctttac actgttttat tctgtccatc tcagcagttt tttctgtttt tggtcaaaca 2294581 cgatctgtgc agttctttct gttcccgaat ccgttgacac tcttaagttg atttcttttt 2294641 gttcttttat cgatgtatca tgaatgtaat aagaaacccg tccatataga aattgctgcg 2294701 taccctcctg gcctttccgt tcctctagaa catgccgaat cgaaagaagc accccatttt 2294761 gaagcaaatt ctctcctatg tataactctt ttgtttcctt ctcaaacatg cagcgtgaaa 2294821 tatattgagc agcaacaaag ttcacgatta acagcacaag cgctgacaca aaaagaacag 2294881 ctggataaat aaaccctctt gtacgataca ttcacccccc tcctaaatac gaatagactg 2294941 gaaaagcagt ttgatacact ttttggtctt cactctcaat tttcagcaaa acaacaccat 2295001 tttcaatatc agctttcatg gcagtaatat gatctaaaat cggaacatgc cctttgccat 2295061 ccactctttt tcttatcatt gaatgataaa tgtcaaaacg gatgtcttgt ccggaaagat 2295121 tggtgcagat taacacgctc ccatgctcgg ctgtcttaac tgcctgtgat tccttgcatt 2295181 cattcatcat ctgttctatc gaaatcatcc attcctgctg tgtgaaaccg tcatgttcct 2295241 gctgtcgaga caaaaacaga tggataatcg cagctaacga tcctgatatg agcaaaaaga 2295301 ctgagagcga aaataatacg ttaagaagcg tgtagccatt ctgtctgcaa aatgctgagg 2295361 caaaatgatt tttctttata agctgcggct ttgatacata cgttttgata ttcgccctcc 2295421 tcctcccact tcattgcata gatatgattg ttctttgtaa tcgtttttga cgcggctcct 2295481 tcaccactca tgacatattt gctaatgctc tcattcatca tctgatagcc aatttctcgt 2295541 gattccgcca ttttttcatc agccatcagc ttgtcccaca aggggacgac tgtcagcagc 2295601 acaaacagcc acaggcttag cgcagacatt gtttctattg tagaaaaacc tttattttct 2295661 ctccacattg actctcccgc tccctagata aactgttatg tcataaacgg catggccttt 2295721 tactcgtatt tttccgcctg cattcgggtg ccctttctca ttaaattcca aacggtcttt 2295781 taatgtcagc agttctatag aaagtcccgt tgcatacgga cgttcaataa ccgtatcacc 2295841 aatgactaat tgatattctt ttttatgaaa gagaattttt gttctttgtt gacgggaaat 2295901 agcagtctgc tgtgtgagca taatatcatt tttcagctga cttgctgcct gtcggacagc 2295961 tgtattgtca taagcaggag gaagtgtagt gaagacggcc accaggagga tagaggcaag 2296021 gcttaacaca agcaaacttt ctaaaagggt aaaccccttc tcctcgttta atttaatgtt 2296081 caaccttaac ttctccgccg gtgatgataa tgcgcttacc atttggacag acagcatcct 2296141 ttttcacata gccctctgac tgtaaatcgg caaggctcgg agtttgtcct tcatgatcaa 2296201 gctcaaatgc agtcatttgt gccttaacca tgttttgtaa gccttcacag cccttttttt 2296261 gaatggtttg attatgtttc gtgacgttcg gtatcgtaat taaaagcaaa atcgaaataa 2296321 taaagagcac gattaacatt tcaacaagtg taaatccttt ctcattcatc agcctcttcc 2296381 tttcacattt gattcatcat ctgatacata ggcacaagca tagataaata cacaagtaag 2296441 atcatcgctg caacaaatcc ataaatcatt ggctgaagga tgcctgtcca tttttgcgct 2296501 ttgtgttcca gccgctgtaa tatgaattgg ctgtatgtga aaagctcccg atccaatcgg 2296561 ccgctcagct ggccgtgaga tatgactttt gataaatcag tttcataaaa aaggcttcca 2296621 caaatagcgg attcaattga ctcaccggct tttagccgtt caatcaattg ttcagcctcg 2296681 cagcggtaga aagggagaaa cgtttgatgt ttaaatgcat taaggctgtc ataaattgag 2296741 aggcctgatt ttaaaaggct gcttagctgc aaagaaaaaa agtagctgtt aaacagcttt 2296801 acaagctttc caaccaaagg aatcctgata caaatcagca tttgccgggc aggtgatttt 2296861 ttcttaaaca caagccaata ataaatcccg atacctgctg taaaaagaac aagcaaaatg 2296921 atcacaagat caatatgctg aaaaaaagca aaaagcatat cggttgaacg tgaggtttcc 2296981 atattcatcg attgatagat accggaaaac tgaggaatga tgatggactg taacatataa 2297041 aacatgacag cgaccgtaaa gatgaggaaa agcggatagc gcagcactct tttcagctgg 2297101 tctgcctgtg caatttttcg ttccagcagc tctccgctct ggatcattga agcaggcagt 2297161 tcaccatgtg tttcagcaaa ataacaaata cctacggctt ccttatgaaa tgacaaactc 2297221 tttagtactt gataaaacgg agccccttcc ctcaaacaag tgaccgaatc agtcaagtca 2297281 gccgcctgcc tcttattcat ctgaagttcc atcaggcgta atccatccag aagtgtatat 2297341 ccgcccgcag tcatttcacc gagcctcttt aataacctgg cttgatcctt taacaaccag 2297401 acttttctaa tctttttcat gataaaccca ccggtcatag ttgtttgtcg ttaaatagcc 2297461 gagcgcaatt ccttttctga taatttgacg aagcgtttga tattggtaat ttgcatgatt 2297521 tccttttgcc tcctggatac attgctgaag atttttcccg tatagaagct cataaacgct 2297581 agctctccta gtatttcgtg actgtcggca atacactgat gaacatccgt tttcacaaaa 2297641 cgggcaagcc aaatcaacca agcgctgagc cgctattgca atgacagtct gttcgatttc 2297701 attcatattg ataccgaatt caagcagtct gtaaattgcg ccctttgcgt ctctcgtatg 2297761 aaggctcgtt agtaccagat gtcccgtcat cgctgcccgc accgcaattt cagctgtttc 2297821 cgcgtctctg atctcaccta aaataatcat atcggggtca tggcgcaaaa ttgctttcag 2297881 acctgcggaa taagttacac cggctttttc attcacctga acctgaagaa catcttcgtc 2297941 ccttgtttca acagggtcct ctaatgtgac aatatttcga ttaaagtgtt tttttgcata 2298001 ttgaacgaga gagtataatg tggtagtctt ccctgaacca gtcggcccgg taaaaatgag 2298061 catgccatgg gaatgtttta aaaacgagag taatgtggct cctgtcttcg gaaatagcga 2298121 caatttatca atcgaaggga tattgtattg gggcatcact ctgatcacga ggctttcttc 2298181 attaattgtg ggcagcgttg acattcttaa atgaacattt ccctctttca actttaacgt 2298241 aagcgaaccg ttttgcggct ttcgcctttc acctatatcc attgctgaaa gaaatttaaa 2298301 atgtgaaatc agtcttacgc actcttcttt tttcatgtcc ctttttttca gcaaggcatg 2298361 atcgacccga aaatgaatga tagcgtcccg ctccctcggc acaatgtgaa tatcagaagc 2298421 ctttgttaga tatgcctctt caatcaagtt tttgcttacc ttttctattg aatccaattt 2298481 gattccctct cctttcaacg catattgtag aaaaagaaga aaaggtaatc aaacagggaa 2298541 aacgtgattt tgtgagatgt tatatgctga aaaaccaatt ctttctggca agaaaaaaga 2298601 ctttcaactg aatgtacccc tgtcattata attttcccta taaataaaaa agcagacatg 2298661 gtcaccatgc ctgctagatt ccattttcat tatgctgttt tcgcttattg accagtatct 2298721 ttctcaacgg aaagatcgcc taatgcaaca ataccggtca tttggtcatt ttcaagaatc 2298781 gataaactgc ggatttaatg ctctgtcata agccccttga catcgtatcc ggtcaccctg 2298841 atatgtctgg tgaaaaagcg gggcacgctg cacaaaatat gaaacatcct atagagtccg 2298901 cctttttcga ggtttctttt tcttcttccg ctcctgcagc atatctcccg tccagccttt 2298961 ttttctcaaa tagagataga tcagaactgt agatgtgaca atcaataaga gggaaaagag 2299021 atatccgtat ttccaattca gttccggcat cactgaaaag ttcatccccc ataaggcacc 2299081 cagagctgta atcggagtaa aaagcgtcgt gaaaatggtc agcgctttta caatttcatt 2299141 ccccctatgt gaggtaatga cttcctctga atgcagcaga ttgttaagct ccccttcaaa 2299201 ttcgctgatg tatgtaaatc ccctgtcaat cttcagttgt gtccgctgat aatccttttt 2299261 cccttcattt tgaggtaaaa aggtttcttt caacgccatt tcaatttttt tagcgcttaa 2299321 tatcaaattt ttccaaatca tcagttcatg gcgcaggaga tggacgcggt ttaaaatgct 2299381 tttgctattg tcgtctttaa tttgccatct gagctttctc agcttgactt caaattcatc 2299441 aacaccgatt aaatacgcat tcattagttc gccgagaaga attaaaaacc cctctatcgc 2299501 attgtccgct ctttccattt gccgaacaac ttctttgcct ttaatctctc tcaaaattga 2299561 aaagtcaaag ttgattgtaa aaaaatattg tctggtgata taaaagtgaa aaacagtatg 2299621 gtctttttct tcaccaagcc cctgatcata aacaatcgac ccaaatactg cttcattttc 2299681 cgtttcagtt gtatctactc gcaaaaaatt aacgtgatgg ttattttcaa accacttttc 2299741 acactgaggc cagtgagaaa aatggattag atctcttgcc ttacttcttt cttgaggccc 2299801 catttggtac caaaaccaat cctttcccgt atgtgccttc atgtcaagct cctccaaact 2299861 tttgttcttt attctttaat tgcccaataa ccgcgtcact aaaccagtct gccgcttcaa 2299921 cacatgtttt atgagcattt tcaggtggta tggaatgtag aaagacatcg gaaaagggag 2299981 gtgcatgcct tccttggaga aggcagttgt tttggaattt atcaatttac tagcagtcgc 2300041 tattctcatt ttgttaacag gatttttcgt tgccgtagaa ttttcaatcg taaaagtgcg 2300101 gcgatccaaa attgatcagc ttgtcgcaaa aggaaagaaa ggtgctaaag cggcaaagca 2300161 tgtcatcact caccttgatg aatatttatc agcctgtcag ctgggcatca cagtcgcagc 2300221 tttaggactg ggatggcttg gggaaccgac tgtgcaaact ctgcttcgac cgctttttca 2300281 taaagcaggc ttaaatgaat cgcttaccca cctgctttca ctcgtcatcg catttttagt 2300341 ggttacgtat ttaaatgtcg ttattgggga gctggcgcca aagagtttcg ccattcaaaa 2300401 agcagaaagc attaccttgt tgttcgctaa accgcttatt tggttttata agatcatgtt 2300461 tccattcatt tggctgttga accactctgc ccgattgatt acaggagtgt ttgggctgaa 2300521 gccggcatca gagcatgagc tggcttatac agaggaagaa cttcgggtcc tattggctga 2300581 aagctataaa agcggcgaga tcagaaaaag tgaattaaag tacatgaata atatcttcac 2300641 ctttgataaa cgaatggcaa aggaaattat ggtgccgcga aatgaaatgg ttagtttgtc 2300701 actagatgaa gactccattt caaatcttca ggaaacagtc aagcaaacaa aatatacacg 2300761 gtacccggtt gtaagagagg ataaagataa cgtcattggc gtgattaata tgaaagaagt 2300821 gctgttttcc atgctgacga aagatttttc aatcaagaag catcaaattg aacctttcgt 2300881 acagcccgtt atccatgtaa ttgagacgat tcctatttat aaactattgc tgaaaatgca 2300941 aaaggaacgc actcatatgg cgatcctcat agatgaatat ggcgggacgt ccggtttggt 2301001 cactgtcgag gatattatcg aagaaattgt aggagaaatc cgtgatgaat ttgatgcgga 2301061 tgaagtgcct catatccgcg aacttggaaa ggatcattac ttgttaaatg caaaattatt 2301121 aatcagcgat gttaacagcc tgcttggaac cgatttatca gaggctgaag tagacacctt 2301181 gggcggctgg tttttgacac aaaacataga cgctgagcct gaaagtgcca tagaatatga 2301241 tggctactct tttaaggtaa aagacatcaa cagccatcac attttattta tagaagttaa 2301301 aaaagctgaa tagcccgtga aaggctgttc agctgctatc tttcaagata aacatggcaa 2301361 aggcatcaac actcttttat tttaaaccct ttattggcca gggctttagc aagactttgc 2301421 tctgttttca cattcgaaaa atccagaccc agcttcacga cagtttgggc aatttccggc 2301481 ctgattcctg aaataatagt ctcaatgccg agcaatttgg tgctgtcaat cactttaaaa 2301541 atttgatagg ctaccatggt atcaacgata ggaacgcccg aaatatctaa aaataaatac 2301601 gagagcttta acgctgagca ctgctccagc acagactcca aaatcgtcct cgctctgtgc 2301661 gtatcaattt caccgacaag cggaagaatc ccaattccat cagtaatcgg cataatcggc 2301721 gcactcaatt cattaatcat ttctttttgc gcgtttaatt gtatcatggt cacctggtga 2301781 tattcttccg taaacacttc gatgatctca tcaatgtttt gattcaagat ccggctccac 2301841 tcataaaatt cctgaatgct gatgtcttga gaagaagctt cgctgaattt atgaatccat 2301901 tcaaacatga tgtgcctgaa agtgttaaac tggccgacac tttgtgtaac cgtcacttca 2301961 tgaacggcac ggtctctggc gcattgaaga gaccaccggt tgagctcatc ctctacgtct 2302021 tcttttctaa gggattttgc tacgatggtc accaataatt catgctggtc ttttaacttt 2302081 tgttctagtt tttgctgatc tttcgctgaa tacagccagc tgccgtttga cgtacaaact 2302141 tccagccatt gttgcgtaat atcttttttg tgctctgtta agtgctgatc aagagctatc 2302201 atcttaatga gttacctcct gtttttgaaa aatgtacgct atatatgtat aacgcgtctg 2302261 cctttacaca tactatgttt agattcaatg ggctatagcc aagcggtaag gcaatggact 2302321 ttgactccgt gatcgttggt tcgaatccag ctagcccagt ttctgaacag gtgaaaaacc 2302381 gaagataagc tgattcgtat aaatcagcgg atcttcggtt tttcatcatg cagattgatg 2302441 aaccgttttc ttcttcgata acttcaacag ttctcccggg ttataaccaa tcaccagctt 2302501 tttgttgtct actagaatcg ggcgtcgcaa aagcttcggc ttctcgatta aaagttccag 2302561 cacctcattt accgtcattt cttcaatgtt taaatttaaa tttttgaaag tctggcttct 2302621 tgtcgccaaa atttcatcaa ttccttctgt cgttaacgat aaaatgtact ttaattcttc 2302681 tcttgtcggg gtttctctga ataagtgccg ttcgttaaat tcaatttgat gtgctttaag 2302741 ccaatgtttt gtttttcggc atgacgtgca gcttggatat gagtaaaaag ttaattgttg 2302801 ttccattcgt tttttcctcc tcagttaacc atctctttgt agaataacta cccggatcat 2302861 ttttcattta aaccatttac agaacttttt tcggattatt ttttaaaaaa cattcataca 2302921 atagaaaaca caatcaaagg gacaaattcc atttgtatat taataatgaa aatgtttaca 2302981 tttctaggtg tgatctatta taataacagt cagagggact ctcgggaggg gataaaaatg 2303041 aatcgcatgt tccgggtgtt aggattttgg acgggaattt ttgcagtcat gttttattta 2303101 ggtgatatga aagatgcttc ccttttattt tttggacaga cgatcttatt tgtgtttcta 2303161 tcgtatttga acttaaccga acgcatgtat atttatattt ttggcgctta tttaacaatt 2303221 ttcttcgccg gctttacata ttactcaatt tttattatgg tgcccggcgg cggaggccat 2303281 taaatgcaga aagagacaaa ccttatcggt ttgtctcttt ttttacaatg aaaacccatt 2303341 taaaaacgga ttttgatcct gctcagtcag tacgtctgtt tcaggtccat ggccgcttaa 2303401 caccagcgtg tgttccggaa gcgtaagcag tttttcatga atggacgtca gcagcgtctc 2303461 ttgattgccg cctattaaat ccgtacgtcc tataccgcct tggaacaaga catctccgga 2303521 aatgaccaag tctgcatctt tcacgtagta agacacactg cctggtgaat gtcccggcgt 2303581 aaataatgtt tccaaatgaa acggcccgat attcaactca ccgtcgcctt caattagatg 2303641 atctgcaggc ttagctgtga cttctatccc tcgcagcatg ccggagccgt ttaaagaagc 2303701 gtccgcaagc caattttttt cattttgatg caggtaaaca gggatatccc atttttctct 2303761 cacttcatca agcgccccaa tatggtcaaa atgggcatgt gtaagcaaaa tggctaaagg 2303821 cgtcagccct ttttctttta tgtattgatt gattttatgt ccctcgccgc ccggatcaaa 2303881 aatcagacat tgatcatcac tgatgagaaa atatgcgttc gcttgaatcg gccctactgg 2303941 cattcgtctc catttcacta ttatcacctc tttctttttt atgctcttat tatgagggtt 2304001 tttgaaaaaa gattcaaaca atcgcaatga aaacgctatc gacaaaccta taaaaaacag 2304061 gtagaataaa actggaaaga attgcaggtt tttcaatgta aagggggctg tgttatgtta 2304121 cttgtcgtga ttttcggcct tgtcgctctt ttcgctttat ggggagtctt gcgttctgtt 2304181 agaaataaaa atatactcgg gtttttatta gccggtgcca ccttatttgt ctttggatgg 2304241 tttaccgtga tgaccgtaat aaacagcggg tatccaaccg cacattaaaa cctgtatccg 2304301 atcggataca ggtttatttt tatggctgta aatgtttatt gacactttct attttgctct 2304361 caagcgtcgt ttttttgtca cgcctgtcat cgatacggat attcgttgcc actctgtgca 2304421 atcctttttg aaatggcgct tcgtgaattg cctgaataac tgcaaaaagg tcactgagtt 2304481 ctccctcgat cagcgtattc atcggtgtca gctgatattt gattttccct tctgcttgat 2304541 atccttctaa tatcttttgc acatcggcta cgtaagcact gacactgggt gtttccgtac 2304601 cgattgggat aatggttaca tctgcgatag ccatcgttat tccatctcct tttgatcaat 2304661 gatgagttgc ttcgtttcat gtgatttcaa taaaataatt tgctcaaaat gaaagccgta 2304721 taacgcatat ttcccgttcg gagatatttg aatcggctcc atttcccgca gagacacaag 2304781 atcttttgtc tctcccgatg ctacattgat tgctgcgagc ttatatgcat cgccgctttg 2304841 tttgaatgta taaaacaggc ctcctgcttc atcatagtca tactccattg gagccaaact 2304901 tgtatatttc gcttggagcg gccatttcgc tgtaacaggt gatgttgatt gcggcgtttt 2304961 aaactgatac gtcccttttc ctccggaagc tgatttgaca gtaaaactca tttgatggaa 2305021 agaatcgaag aatagaacgt tatcctcaag cttctgttcc gtcttagaag ctgtatcgaa 2305081 cgtatataaa ggccctgttt tatcgtctct accctctttt acataatcaa atgtattttt 2305141 ggatgtccaa tgaatgaacg gaacctgtac tgggcttaag aaagattcgt cttttttagc 2305201 attcacctga tatgtatgga aatcccagtt ttcattgaat tccgtcacca tcatttgata 2305261 aggatcatac tgattccaag cagcttcaag ctcatacgtt tcgtaatctt tttcgtaaag 2305321 cgtctctcct tctgcattaa gcaaaaccac tgccgtcttt tggctatgtg tgatttgcag 2305381 cagaatcatc tgctccctcg cattgatttg aacatcaacg atttgaccat ccgtttgata 2305441 gagctttttc gctttgcctg taaagatgcg gtacgcaaaa agctctgttt tcgtcggatt 2305501 agacgcagta tataatattg tgctgttatt cagccagcct tccgccccat ccgctttttc 2305561 cgcggaaagc ggtatgatgt cttttttctc atcttttgcc gccgatgcct gtttttgctg 2305621 ctgatgagat ggttcgcatg ccgataaact aaacagcaat accgccagca gaataaaaca 2305681 aactgatctc atcagcattc ccctccgatc atctttattc tctcatattt gcttcggcag 2305741 aaaaaagaaa aagtttcagt tactcatgaa aaaataacgc cctccacaag ataccgcttg 2305801 tggcgttata tatgtgtgaa aactgctgaa acggcaaagg attttggcct tttccaagtt 2305861 ccaccgtata cccttcctta aaataatggt gaataaacca atcacgaaat ccagcatagc 2305921 tgtctatatc ccttactccc ttataaatgt tcccgcttaa ctcctcaaac tcctttatga 2305981 cggcagcaga ttcctcaggc tcaaggcctt tatagcccca ataaatttct tctccttgag 2306041 tatgaagagc cagcagtctg tcaggcggat tctccgtgat cagccggtac atcgcaatag 2306101 attccggctc cgtaagcgga gagattcccg gaaaatcgcg gtagctgggt gctgtcggtt 2306161 ttcggtattt ttcaatttcc cataatgatg gaaattgttt atttaaatca accccgttta 2306221 tattcgcctt ccattcatta aaatttggac gatgttcatt tagcctttcg agttcatctc 2306281 ttctggctcc catgacttct gatccgttta aaacaagatc aacgccatcc ggattgacaa 2306341 gaggaacgag ggataaggat gtgctgttaa acagctttat gggagaaaag ccaaagaaag 2306401 gcgaattgca gcataatgac atacagtatt ccttaaacca ttttagcagg acagacgttg 2306461 taatccactc attcgcatga aatgacgcgt tcatatggac cttttttacg gcatgctccc 2306521 caccagcctt cagctcccag ataggcctgc cgagtacaga acggccaatt tcccggcatg 2306581 agacaaacgg aaaaacatca ataatcttct ttatttcctt ttcaacagct gaatcatcat 2306641 agattttctc ttgctcaatc cagctatctg aaagtttcag ctgccgaggc tgtaaaaagc 2306701 gctttatgtc ctgaatggtt tgaagctctt tgccgctatg ctcctctatc acataaccag 2306761 ggcaatacaa ttgatgtttt tgtgcggagc gatttgcact tttaagcaat tcctcgtcta 2306821 tcttcagttc tttcgccaca ttggccaaat tgttcttgat ctcaggtttc accgtaataa 2306881 acgccatcat catccccctt ttttgttact atatgacagc gtatttaaaa aaagaaagcc 2306941 tcccgctcac ttcgatgcgg gagacattgt gattatgatg cctgatcaag catttgtttt 2307001 tctttccgct ttgacgaatt gtccagcctt ttctggtcat aaaatcgcaa caaatcccca 2307061 taaatgattt catcagaaag tgatagctcc tgttttgctt tatcagcaaa tgcttcacat 2307121 tgttttgtct cttctaacgg ttttcccgtc tctttgtcat aacacgcacc gtctgtataa 2307181 acaacctgat ctgtgataaa gctcccgtcc cggagcaccg tgaagtccag tttttcgtct 2307241 gaaagcagat cgttgccgaa ttgaatttga tctttcgtat caatccctaa aagattcatc 2307301 agcgtcggcc tgatatcaat ctgcccgcct actgtttcaa tggtttgcgg ctttttatca 2307361 gtaatacccg gaatatgaat gaccagcggc actttttgga gctgtacctc ttcaaatggg 2307421 gttatttctt ttcctaaaaa ctgccccatc gcttcattat ggttttctga tataccataa 2307481 tggtcaccat ataatacaat aacagagttg tcgtataacc cgtcttcctt cagcttttcg 2307541 ataaaccgtt tcagcgcctc atcctgataa cgcactgtcg gaaaatattt atttagcgtc 2307601 tggctgtttg aatcatattc atcaatcaat tgatcctctt catcaagatc aaacgggaag 2307661 tggttcgtca gtgtaatcag cctcgagtaa aacggctgag gcagattttt catcagctct 2307721 gaggactgct caaaaaattc tttatcctta agtccccagc cgactgaatt ttcgtcagtt 2307781 acatcatacg agttaatatc aaaaaacgaa tcatatccaa atgagtcgta cattaaatca 2307841 cgattccaaa agctcttatt attagcgtgg agcaccgctg aatagtatcc gctgtttttc 2307901 aaaatttcag gagcggccat atattgattg cccgcattcg taaaaaatac ggcacctcgt 2307961 ccaagcggat acagtgaatt gtccacgata aattcagaat ccgaggtttt cccctggcct 2308021 gtttggtggt aaacattatt aaagttgtag ctctgtttta taaagtcatt cagaaaaggc 2308081 gtgatttctt ctccattcaa tttttcatta atcacgaagc tttgcgtcga ctctaaggat 2308141 acgagaatga cgttccttcc ttttgcagcg ccgaataagc gtttgttggc atccttcgca 2308201 ttagcggtta cgtagttttc aatctccgtc aggctgttgc tgtctgccaa cgctctctgt 2308261 gcggattgct ttgactgaag aacgccatcg taaatatgaa aattaaacag gctaatgttt 2308321 ttaacaagca tttctctgtc aaatgagcgt gtcaatagct gaggtctttc cgcctcagac 2308381 aagcccaggt tgaagaaata aacagaagca acgaacaaaa aataagccgc ccgttcattt 2308441 ttcgttgagg gaatgtccga ttgaaaagct ttttgccgga tgtgaagcca tattaaaacc 2308501 gcaatatcta cagctaatag gaggtctgtc ggctcaagaa gtgttccgat gctgcttccg 2308561 agatcaccca tattgctcgt ttgaaaaaga acagggattg ttaagaaatc attgtaaaaa 2308621 cggtaaaaaa ccatatttgc cagcaataca aacgtgacaa gacagctcat cgcgataatg 2308681 tagcgatttc tgtttttgcc ttttaaaaac aggctgaggc caaaaataag caacaaaaaa 2308741 ctcaatgggt tgataaacag aataaattcc tgtgttagat tgtcgatttt aatatgaaaa 2308801 ctggttttgt aaacagcata cgttttcagc cacatcaata aaatggcaat cagcataaat 2308861 gaaatcttcg aaaaaaacgt ttttcgcatt tcaacctcct atgcagcacg ctcaaaaaaa 2308921 tcagtctatt cccaacattc tcattaacac atcaaattaa atcttaacct gagcacaaca 2308981 aaaaatcaat ttcatttaca caattttaac aattttgatg tttcagccat tcatttttag 2309041 cgatccaagc gcctccgata acgccggcat catttccaag tgctgcgatt gaaatatcag 2309101 cagcttgggc tgcccgcgga aacgcgcatt tgcggaatgt tttctcgact tttgatctca 2309161 gcagttctcc ggctctcgat acgccgccgc caagaacgat tttggatgga ttaagcgagc 2309221 ttgccaaatt tccgagcacc aaaccaagat gcttggctac ataatcaacc acctcaaggg 2309281 caatttcatc attttcaccc gccgcttcaa acacatctcg cgctgacaat tgttcggttg 2309341 cttttaaacg tgtcgtcttt ttagcatttg ctattttttc ttttgcaatt cttacaattc 2309401 cggttgctga cgcaattgtt tcgatacagc ccgttttgcc gcagttgcag ggcgctccgc 2309461 cttcagggat gctgcaaata tggccgattt ctccgccggc gccatttata ccatgtacaa 2309521 tttcaccatt tgcaatgatg ccgccgccaa ctcctgtgcc aagcgtcacg agaatgacgt 2309581 cttttgcgcc atcacccgct cccttccaca tttccccgag cgcagcaata ttcgcgtcat 2309641 tttctataac agctgggatg ccggtttctg tctccagatg gtttttcaaa gcataatttt 2309701 tccaccctag atttactgtt tcataaacca ctcctgccgc catatctaca gggcctggtg 2309761 cacccattcc gatgtatttg atgatgtgct tcggtttttg cagctcatcc agcttgctgt 2309821 cgattgtttt tgcaattgtg acagtaatcg tgtcgccggt tttatctgtc ggaacttccc 2309881 acttatgctg aatttcgcca tattgattaa taaaagcgag tttaatcgtc gttcctccca 2309941 ggtcaatgcc cgcaaaccat atctcgtcca tttttatcac cttagccttt ataaaaatct 2310001 cttccgtttt ttgtttgttc caattctttt cgaaggacag ctgccgctct ggcccactgc 2310061 tccttttcaa tcatgtggtt catgtataat tcctttaatt catccagcat aaactcaatt 2310121 tcaagctctc tgtctccaaa ataaacaatg tggccaaacg tttttaacag ctgctgcaca 2310181 tcataaaatg tattcatttt cctcaccatt tcttgaactt aactatcata agcgtattca 2310241 taaggaagcg gtcagtcaag aagaaaacgc tgacaaaaaa gccagcttcc tttccatatt 2310301 ccacctctat gattctttat tgttttcaat ttgccgctgc agctccttgt agcgctgctc 2310361 cttcggcttc agtttcacag ccgtctggat ggccttttct gcttgtgcaa gctcattttt 2310421 ttccgcatac aataacgcta aattgtaata ggaagcatgg tctttaggtt cttttttcac 2310481 tgctcgttcc aaaagggaaa ccgcctgatc atattcgccg atttgaatat cagaaacagc 2310541 aagaattttc aaaagatcgg cagaggcatc tttttgcgct gcttctccgt tcagcaattc 2310601 tgttacttct tcatactttc cttcctgata cagctcgctt gcctgctgaa tcagcgctga 2310661 ctcctggtgt gaaggcgaat gcaatccgta atataaaaat ccaacagcca aagcaatcag 2310721 caaaaccgct gacaacaatc tttttccaaa ggctccggct ttaggcaacc ccagtgctgc 2310781 tgcagcgaaa aagccgccaa tcaagccgcc gatatgtcct gaattatcaa tattcgaaac 2310841 cgcaaaacca aagcccagat tgatgataat aatgacaata atattggttc ctatagttct 2310901 taaaaacatt tttcgattag acaaagcaac atacagtaat gcacctaagc atccgaatat 2310961 ggctcctgat gcccctgccg aaggatacgg gctgaacaca aaactcgcaa tcgaacccgt 2311021 aatgccagca gccagataaa tcagcaaaaa tctccccgat ccatacatcc gctcaaccgc 2311081 tgtaccaacc gaccataaag ccagcgtatt aaaagctaaa tgcgctatgc cgatgtgaag 2311141 cacgatcggt gtcagaagcc gccaccattc tccttgtgca atcaggctgt tttcttttgc 2311201 tccaaaagcc accagtgtct ccgtattagt gctgcctccg tttatttcga gcaagaaaaa 2311261 catcaggatc tgaagcgcaa taaataaata tgtaaaagtc ggttttccgt tttgaaaaac 2311321 cgccgcttca gtttttctct gttcttcttg tttcagcact agcgaaagga agcgttctcg 2311381 cgccatttgc gcgttttcaa acgaagcgtg ttcctctgaa caatcttctg tacgaaatga 2311441 tggaaaaacc gcttgaagat catctcgaag catcgttcct ctaacgatcg ccggctcaac 2311501 tgacacagtt cccttctcaa aagttttttt tgcaatctct tcccagtcat caactggggc 2311561 ttccgttgaa aaaaacacgt tcagcagctt catccttcgt ctgcccaatt gatgtctgac 2311621 tcgttctact cgttcggcct gctcttcgat gtctctaacc atttcttgac ggaaatcaag 2311681 atcgtgctta taaagacgaa ctagatcatg agaggacttg tccggcgctt ccagccatat 2311741 ttcatctgac tcaccggctt gtatgacgcc atacccgcta ttcaccaggt gcgccgcaat 2311801 tttccaatat gtatactcca gcaaaaacat gtttaccgct ccaatagttt tttttcatta 2311861 taacagctgg cgctccgaaa cgcctactga aagcaaaaaa tcccgttttt cacgggattt 2311921 tagaaagctt gctgtataaa cttattgcgg ataaatggaa ttcttaaaaa caaatggata 2311981 aaagaccgcc tgattcctgg ctggctgagt acagtattca taagacggta gcgattttga 2312041 taaaacatga cggcagaaac cgcgaaaatg gcatatatca aaagtttttt catgatatcc 2312101 ctcctgccaa tagggtttgt tattctacct tatttattct cgaataaggg acaggaaagt 2312161 tatgaaaaac aagaaataat ccgatcctct gttatcagct tatgtaccgg gatgtcatgc 2312221 ggcagacggg gtacgtgcgc aaacaactgg cactccaaaa gcaaagagac tgtcttccct 2312281 tcatattcac ttaaatagcg atcataatag ccgcctccaa agccgaccct aaacccgtta 2312341 acatcaaaac aaacacccgg aacgatcatc aagtcaattt gtgatgggtt tacttctttt 2312401 gttttttcaa ttaccggctc gagcagtccg gcgtacacgg tttcgagctg atcatcagtc 2312461 tgatatgtgc gaaattgcat tttcttcgtg tccggatggc attttgggat gcaaacttgt 2312521 ttcccttctt cccaagcctg ctcaatgaca ggacgcgtcg gtatctctaa tcctctggaa 2312581 atagtgacgg caatggtgcc ggcattttgc cactccggca gagaaaacaa gtacttatac 2312641 atacgttccg ttttttgaag aatatcttca tttgataaag cagacagtgc ctccagcgtc 2312701 ttttttctta attgtgattt catctctcat ccccctcgga atagaaaaaa agccagaacc 2312761 tttttcaaag ctctggcttt tttcttacac ctcaaacagc aaagctgtta ttttgtttca 2312821 cggtgtaacg tagatttttt atcacgtggg caatattttt taaattcaac gcggtctgga 2312881 ttgttgcgtt tgttcttttt agaaatatag ttacgctcac cacattcagt gcaagccaaa 2312941 gtaatattaa cgcgcattat tttccctcca aactaaaatc atttacttat tcagacttat 2313001 atataatacc actataatgg acggaatgct aggctgtttt tcaatgaatt gctgaattat 2313061 tgaagatacg ctcataaagc tgcaaatatg atgacataat gagtcggggg tggtggagct 2313121 tgaacacttg ttgtctgcca gcttctttta tccggcgggc tttttcccgg tcttttaaaa 2313181 aactgtccag cagatcagca gcttcctgta cgagcgtaaa atcagcgatg attgccgttt 2313241 tgtcatgaac cgcataatca caaaaaccac ctgactgaga aacgacagtc agcacacctt 2313301 gttccatgct ttcttgcgcg gcaagcccaa acggttcata agaactaggg aaaacagcca 2313361 tttcacagtg agacagtaac gttctgatat ctttcctatt tagaaacggc agaaacatga 2313421 cgcgatcctt caggttatat gccgcagcca atttctcata gcaggacaga gacggcccct 2313481 ccccagccag cactagatag aggtcaggct gacgctgctt caagatggca aacaccttta 2313541 acagctgcga taatcctttt tccggaacaa accttccata tgaaaagagg aatcttctat 2313601 tcatgcttct cgggattttc cccttctctt cctccataga tgcagggctt gggataacgg 2313661 ttattttctt atgtgccgcc ttatcaagag accgcttcat aaatgtgctt aatacgatca 2313721 atgcatcagc ggattctata aggagccgtt cggtcatgag cctgtatggg tgtggggctt 2313781 ctcggcacac cttcttcctt tcgctttcaa gaccgtggat tgtcgcagca agcggaaggc 2313841 caagccgttg tttcaaatac tgggcggcag gggcagttgt gtcatcatgg gcatgaatca 2313901 gatcaaagcg tttattgtgt gataacacat ggcgaaccat tgtaaagtta gcatcagcta 2313961 tgtaatcttc aaacttcgca tacgaaaaca gctgcccgct cggagtaaaa accgtaatgt 2314021 tgatatgagg gtttaaatag gaaatgaggc ggtttaaatg gacaccgagc ccgcttttcg 2314081 gctcatcggg atgttcgggt gaaagcatga gaatgttcac cgttcttttt cccctctccc 2314141 ataacaggtg tatgcagaaa attgcgcctc ccacctggtg tgcgcttctt caatctgaaa 2314201 actgtttata tgacgaatcc cattttcatc aagatagatg tcgtctgtac cggcaagctt 2314261 gagagagaca ttcattgaat tcacaattct gtattcagcc cgatatacag catcaccagc 2314321 cgcctgtcta atcgtccatt ctcctttatc atacgttgtg cgttttgtcc tgacagcttc 2314381 aatgtctttt cttttgatga caatgcgcaa ttcttttatc atatcctgcg ttttttcgaa 2314441 aaggaccgct tcagccagcc gcattgtttc ttctgagatt tcccagctta cggtcaaggt 2314501 gtgagcgttt tgaatgatta tgtcgaatgt gtccctaaaa aaggaaagct tatgtcgtat 2314561 attataggga aatgggtgtt tatccatgga ctcctaacat tctcctttcc aatcgttcac 2314621 ttcgtgttcc tattaaacca ttacatgaag aagaagcgaa gaaagatttc tcgacaaaat 2314681 ctcgtttttt tcgcgaattc ctttagaaac tattggtttt atggtataaa aaagaaggat 2314741 aaaaaaagaa tagaaggtga tgaaacgtgg aaattgctat tattgcgttg tttatcgtca 2314801 gtatagcgct aattgcattc tcatattctc aaagagaccc gatgaaagat gtagaacagg 2314861 agctcgaaac actgcagctt tctgcgatgc aggaaattta caagctcaaa aagaaaatga 2314921 cagtgcttga ggaagaatta ctggaaacaa accttgtcat tcgcaaatca aagcagaacg 2314981 acatcaatca aaaaatcgct aaacaaatac tttctaaata taataacggt atgtcagctg 2315041 aagcgattgc taaagctgaa catgtatcag tggaagacgt gaatacgatt atcaaagata 2315101 atgagaaggt gctcgtatga caaaacgggg cattcaggca tttgctggcg gcatcatttt 2315161 agcgacagcc gttcttgcag ctgtttttta tctgactgac gaagaccagg ccgctgctgt 2315221 aaaagataat aaaacagtaa ccgaacaaga cgtgaacaat tatcttgatt ctaaaaaatt 2315281 ggtttctgtc aaccgtgatg aatatcaaaa acttctcgat tcaaaagaga aatccttaaa 2315341 caatgacagc ggctcagaca cgaaatcaga caaagtcaaa acctacaagc tcaccattaa 2315401 agacggcatg agcacggcgg atgtatctgc tattcttgaa aaagagggca ttatctcttc 2315461 ggctcaagac tttaatgact atgtcattga tgccggctat cacaaagaaa ttcgtgccgg 2315521 cgagtttaaa gtaaaatcag acatgagttt caaaaagatc gtaaaaacgt taacacgata 2315581 aaaaaacagg ctgactcagc ctgttttttt catccaaact ttcctgaaat gtaatcgagc 2315641 gttctttggt ccttcgggtt agagaacatt ttattcgtat tgtcgcattc aacaagctcg 2315701 cccatgtaga aaaaggcggt ttgatcagaa acccttgctg cctgctgcat gttatgcgtg 2315761 acaatgacaa ttgtatattt atctttcagc tctagaatga gttcttcaat ttttctcgtt 2315821 gagattggat ctagtgcaga tgtcggttca tccatcagca aaatatcagg attggtcgca 2315881 agtgctctgg cgatgcaaag acgctgctgc tggccccctg acagcgaaag agcggacgta 2315941 tgcaatcgat ccttcacctc atcccataac gccacgtctt ttaatgactt ttccacaatt 2316001 tcctgaagct tcttcttatt tttggtgccg tggactctcg gtccgtaagc cacattatca 2316061 aaaatagatt gcggaaacgg attccctttt tggaatacca tgccgatatt ttttcgcaaa 2316121 tccacgatgt ccactttatc ctttaaaatg ttgctgccat tatagttcag ctcacctgca 2316181 agctttacat tcggcgtcat ttgaatcatt aaattcaatg tcttgataaa ggtcgatttc 2316241 ccgcatccgg atggtccgat aatcgccgta acctcatttt cataaatgct caaattgata 2316301 ttttttaaag catgatgctg cccataccat aagttcattc cattgacttg atatacttcc 2316361 tgtttcatta cagcttcggt agcaatactc attgccgccc tcctatccga atttcccgtt 2316421 aatataatcc tctgtctttt gctttttcgg actcgtgaaa atctgttcgg tctgtccgta 2316481 ttctacaagc tcgccgttta aaaagaatgc cgtccggtca gaaacccgca gagcctgctg 2316541 catattgtgc gtgacaataa taattgagta ttctcttttc aatcctgtaa ttaattcctc 2316601 tatttttgca tttgaaatcg gatcaagcgc tgaagctggt tcatcaagca gaagaacagc 2316661 cggcttcatc gcaagcgttc tcgcgatgca taaacgctgc tgctggccgc cggataacga 2316721 gagtgcggat gaatgtaaac gatccttcac ctcatcccag agcgctgctt ttgttaaact 2316781 ttcttccaca atttcatcta aaacagcttt attccgctct ccggcatatt tcaatgcatg 2316841 tgtgatattc gcatagatcg atttcggaaa tggatttggt ttttggaaaa ccattccgat 2316901 ttctcttctc aagctgacaa cgttaatatt gccgcccaat atatttaatc cctcataaag 2316961 gatttcacct tccgctcttg cagatggaat taaatcgttc attcggttaa tatttctcaa 2317021 aaaagtagat tttccgcatc ccgacggccc aattaaagca gtcaccgcat ttttttcaat 2317081 atccatgttt acatgatgaa cggcttgttt atttccgtaa taaatggaca gatctttgac 2317141 ctcaagcacg tggttctgct tcggaacaat aacagctcgc tcaggttttt cttttaccat 2317201 ttgttcagac atgtttttcg cctctttccg ttctaatttg ccgtaagctt tttgtagatc 2317261 atcgtgccaa gccatctcgc cgcgagatta aacacaagaa cagaaatcac cagcacggca 2317321 gaaccaccgt tggcaatcgc ttcagcatcc ggaatcattc cttgtgtatt gacgttccaa 2317381 atgtggaccg caagtgtttc agcgggcctg aaaatattaa gcggtgatgt ttccgaaaac 2317441 gggttccact ccgtaaaatt aagacgcggt gttgtcaggc ctgccgtaaa taataatgcg 2317501 gccgcttccc cgaacaccct tcctgacgct aaaattgctc ctgtgatgat agaaggaatc 2317561 gcacttggaa ttaaaactgt ttttacggta tgccagcgtg atacacctaa agcgagagag 2317621 gcttccttca gatctttagg gactgaacgg atcgcgtctt ctgtcacacg caccatgaca 2317681 ggaaggttaa aaacagttaa cgcaagcgct ccgcctatga tcgtataacc ccagcctgtt 2317741 aagttgacaa acatcaataa tccaaacatc ccaatgacaa tagacggaag agatgaaagc 2317801 acctctatac atgttctaat gaagtcagtt actttgttat taggcgcgta ttcagccatg 2317861 aagactccgc cgcccacacc gagcgggatt gtaatcagca ttgtaataaa caaaatataa 2317921 aaggagttaa acagctgatc tcgtatgcct cctccagctg caatggcgct cgactttgtt 2317981 gtaataaatt gaaaactgag ctgagaaaca ccgtttataa taatatagga aaacaaacct 2318041 actaaaatgg cagcgataat ggctgcacac aaaccaaaca ttccggtcgc cagtttatct 2318101 gttattttgc ggttcattac actttcctcc tagatgacaa gtagcgaata agcaggatga 2318161 acaagaatga catcaccaga agcacaagcc ccattgacca cagcgtattg ttttcaacac 2318221 ttccgtatgt ggtgtggccc atattcagcg tgatgatcgt tgtcagcgtt cccgcagtgt 2318281 caaacgggct ttccggcaat actcttgtat ttccaatgac catctgaaca gccaaagctt 2318341 caccgaacgc ccgagccatg cctaacacaa cagctgtcat caatgttgga aaagctgcag 2318401 gcacaagtac ttttctgatc gtctgccatc ttgtggcacc aagcgcgtaa gaaccctctc 2318461 gtaaactctt cggaagagaa gccattgcat cagcagaaat cgatgtgatc gtcggcagaa 2318521 tcatgacgga aaggacaatc gttcccgcca ataaactgtg ccctgttccg ctcgatttga 2318581 actgggcgat aaacggcacc aatactgtaa gacctatgaa tccataaaca acagatggaa 2318641 taccgactaa aagctcaatc accggctgca gcactttctt tccccaattc ggggcaatct 2318701 ctgtcataaa aatcgcacct gcaatgccaa gcggcgcagc gattagagca gaaagaatcg 2318761 ttactgcaaa tgagccaaaa ataaatggca gcactccgta tttcggatca ctatctgtag 2318821 gattccaatt taagctcgtt aagaattcaa ttgggcttac accatttaca agaaaagatt 2318881 gcagcccctt aacgccgagg aaaatggtaa tcgcaacaga tgccgcaatc ataatcagtg 2318941 cacaagctgt gactatcatt cttccccgaa cttcatccaa ttgccgattt tgcctagagc 2319001 tgattaagcg ctcgctcaca gacatatttt ctctattgtt tatcattgtt ttacactcct 2319061 atgaatgtgt taagaggaga aacggttgtc cccgcactcc tctttttatt aagatcagct 2319121 ttgcttcccg ttggcatcac gtgtcacttt catatcagta accggaatgt agccttggtc 2319181 agtaacaatg cttttttgaa tgtcttcact ctttagataa tcaagaaatt ctttagctaa 2319241 acctgtcgct tcaccttttg tataagaatg ttgataagcc cagatcggat actcgccagt 2319301 tgctacattt ttcgcttcag gtttaacacc gtcaatagat agagcagtta ctttgtcatc 2319361 tgttaaatat gagaatgcaa gatatccaat cgctcccgga gtatcagcaa tgatcttttt 2319421 caccgtgttg gaggaatctt cagtaatgcc ttctgcaggc tccgctccgt caagcgcata 2319481 tttcacaaat gtagcacgtg tgccggaaga atcagggcgg tttacaagtg taatcttttg 2319541 gtctttgccg ccgagctctt tccagttttt gattttgcca gtgaagattt ttttcaattc 2319601 atcttttgaa atatccttta caccagcatc agggtttaca gctgctgcca taccaactac 2319661 agcgacttga tgatcgacaa gcgcttttgc atcgatgcct tctttttctt cagcaaaaac 2319721 gtctgaattc ccgatctgaa cagctccttc agagacttga gaaagccctg ttccagaacc 2319781 gccagcttgt acctgtatat cagcatcagg gttttcttcc ataaattttt ccgcggctgc 2319841 aagtactagt ggctgcattg ccgatgaacc agaaatggtt aaagaacctg atgccttttc 2319901 ttctcctttt gcagaatcgc tattcgattt tttactttct cctgcatttc cgcatgcagc 2319961 tgcaatcatc ataaaagcag ccatcagaag cataagcacc aatttgtttt ttttcatttc 2320021 ctgaattccc cctgcgtata atgtgtaatt tgtcctacac gtatagagta aaggttctat 2320081 gtaaaaaggg tttgaaccga atgttaaggt tttgtaaatc agtgcgtttt ttgtataaaa 2320141 aaaacgccca catcatgtga gcgttttttt ttagttatca gaagacgttg tgttttctgc 2320201 attttcttca attttgtctt tattcttttg ctgagtacct tctttgtcct gcttcgattt 2320261 cagctcaaaa tatttatcca ttacttccct gccgatttcg tttgtaattg agtatctttg 2320321 attgtaatca atgtaagtcc aaggaactac gacagaaata gcaatctcag gattgtcagc 2320381 tggtgcataa gccacaagcg tcgtattata agtgtctgtt cctgtttttg atttatccgg 2320441 tccgtcgtaa aatgattggg ctgttcctgt ttttgcagct ggtttatacg atgctgaagc 2320501 cagttgacct gcagctgtcc ctttagtggc aacccgtcta aaaccggctt ggacctcttc 2320561 aatatagcta ctcttcatat cgactttatt caatacttca ggctgaacag aatcaacgac 2320621 tgcgccgatc ccttttttcg catttgaatc tctgacttcc tttacaagct gaggcttcat 2320681 gcggtagcca ccatttgcta tggtggagac atattgagcc aattccagcg gtgtataagt 2320741 atcatactgt ccaatggcga aatcaagcaa gaaaccagat aatctgcttg tacctttata 2320801 tcccgtcatt tcatttggta gatcaattcc tgtttttact cctaatccaa attgactgaa 2320861 ataatttctg aaggtatcaa atgcagaagt atccaaaggc aatgcttggt gaggtttata 2320921 ttcaccttta ccaactgcaa ttgctgtttt aaacataaaa acgtttgatg acttctctaa 2320981 tgcagtttga ataccaaccg gccctaagtt ttgccaagat tttttccctc ttttatcctg 2321041 gccgatatac aatggttcat ccttaaatac agtattcaaa ttaatcgctc cagtttgaag 2321101 accggtcaaa acggttgcac cttttacagc tgatcccata gcgtaggatg aagtcatggc 2321161 tcctaatgca taatcatcaa acttataggc tccattttct cgtttaatct gcttccctgc 2321221 cattgtcagc acttcgccgt ttctagggtc catcatgaca acgaatgcac gatccaacaa 2321281 ttcggtacta ggtcttgctt tagcagcttt aagttttttc tcaataattt tttccactga 2321341 tttttgcaaa tcaatatcaa ttgttagtac aagatctttc ccggctttgc cttcagatac 2321401 cgtttttgtt cccgtgacat tgccttttga atctgtgata ttttcgactt ttgctttttg 2321461 gccctgcaga aggctttcat attggtattc cagatagctt tttccgaccc tgtcatttcg 2321521 gctgtagcca agcgacagat aatggtcgag caagttggac ggcaatcctt cattagagct 2321581 ggaaacactt ccgagcactg agcgaagaag gtttttataa ggatattcac gttcccaatc 2321641 ggacgtgaca tcaacacctg gcagttcgtc taaatgttca cttaccactg ccatttcctt 2321701 cgctgataca tcttcgtttt tgatatattg aggggtcaat gcatagcccg aatccatctg 2321761 tcttttgata gcaaggatct gcatatcttt atccgtcaat tcattcagct gcttatcagt 2321821 aatccgtttt agctgaagct ggtataaatc gtcatcggat atttttttgt cttcaacctg 2321881 ctgtctttct ttagagctaa tgagcttttt cgcttctttc ggtctagtca aaatccaata 2321941 atctttttta tcccgttctg ttactttttt tgtatcgact ttgatcatgt cagacagctt 2322001 ttttgcgatc tttaagcgct gttcttgcgt ggtcgattta gatctcgtgt atgtgattgc 2322061 atttaaagcc ttatttgtca caatggcatt aaagtttcga tcataaattt tcccgcgtgg 2322121 taccgctgag ctgacttcac tttgttcctg cttattcgct tggtttttgt aatcatcacc 2322181 ttgcacgatc tgcttgatgc ccagttccac aataatccag gtaaatataa caaaggcagc 2322241 taaaaataaa atattcagcc ggatcggaag cgacttcttt ttctctttat gattttgctt 2322301 ttttggttta tttctcctca taacatcacc ttttctattt acagaaagaa aagacactca 2322361 agtaagagtg ccagttttca ttttaaaggt tttttcgact tttttctaca gataacccct 2322421 ttttggcaaa aaaattatct ctcgcctttt aaaagggtcg gttctgttac ccgtttttgg 2322481 ccgtcttctt ccatggtttc attttcccct tctttctcct taaaacgaat atccttgaca 2322541 aagtaataaa tcaaaggatg tcctataccc aatatcgcaa gtgacaaagg aattcccaca 2322601 tcctctttca gaagggccac aatcaggaga aagcacaaaa tggaaacaat tctgccggcg 2322661 ttcaagaaca tttctctaag cacgatatat tcaattcttg cttttctggc atgcctcgcg 2322721 cgccctatca catcatatgt aagtgataca tatggcacaa gcaacagagg atagccgatg 2322781 gcaataaaaa cgccgtacgt taataatgtc gaaaagctca tatggaacag aatcaaaaac 2322841 agcgcgccat acaaaataag tccgcccagc aaaatcgatt tttttctcgc ctttttctta 2322901 atcagcctgg atgcaaagta gtaggcaaag aaggaaacag ctgaattgac aagaccgaat 2322961 gtaccgagag caagctcgct gtttgtctca ataaatacaa acacactgat taaaaagaca 2323021 aaaatccctt ctctcaaacc ctgaaaaaaa tgcgcattcg tgattctccg ccaattcata 2323081 ttgctatggc gctctccaaa tactttgctc agcataaaac ggccctttga ttctctccgt 2323141 tttaagaaaa agctcatcac gacagccagg gcaaataaac tgagggagag actgaaaatc 2323201 actgtataac ccgtattatt ttcaagcctt gagatcacga atccggctac aatcgggccg 2323261 atcattcctg cagaggaaga cagaatgccc ataaacccgt tgaaaaagtc tcgtgtatcc 2323321 ggctctgtta tttcaaaggt cagcacgtta aacgctagcc aataaaagcc atagccaact 2323381 ccgagcaccg cgccgattag cacgaggcgg ctggccgccg tttctccggc taaaagcaca 2323441 cttaaataaa aggcagctaa aaaaatgacg ccgaacctta aaatgaatac cctgtctatt 2323501 tttttggcta accgtccagc caaataaaag gttatcggct gcattgtcac aatggataaa 2323561 ttatatatcg ccaaatcaat aaatttccct gactgcttcc aaagatacac attaacaaat 2323621 gtattggaca gtgcaattcc cagcgagtaa agcccgccaa tggtcagcag aaagagtaag 2323681 cctttgttta cgtctacatc gcctatcact ttttttagtt tgctcattac tgactcccct 2323741 ttactatccc ttagtctgtc tcactcaaac cgagatatgt aaaaagaaga cataaaaaaa 2323801 caaggtccca taatgaggac cttgtttgtg ccattatttt gcttcgctgt atagacgagc 2323861 cacttcgtcc cagtttacaa cattccagaa agctgaaatg taatcaggac ggcggttttg 2323921 atagttaagg tagtaagcat gctcccaaac gtcaagacct aagataggcg ttttgccttc 2323981 tgaaagcgga gaatcttggt ttggcgtgct tgtgatttca agtttaccgt tgttcacaac 2324041 aagccatgcc cagccagaac cgaagcgtcc agctgctgct gctgcgaatt gctctttgaa 2324101 tttgtcaaag cttccaaata cactgttaat ctcttcagca agcgcgccag tcggttcgcc 2324161 tccgccgttt ggagataaaa gtgtccagaa taatttgtgg ttcgcgtgtc cgccgccgtt 2324221 gttgcggact gcagtgcgga tgttttcagg aacagaatca agatctgcaa caagctcttc 2324281 aactgatttg ttggcaagag cagtgtttcc ttcaaccgct ttgtttaaat ttgtcacgta 2324341 tgtgttgtgg tgtttcgtat ggtgaatagt catagtttcc ttgtcgatat gcggttctaa 2324401 agcatcgtac gcataaggta attctggaag ttcgtaagcc atgataattc ctccttagta 2324461 tatatgtact gaaatgccgc ttcacagcga gcctttcttc attcaatgta acaaaagaat 2324521 gctttgtaat caatgaaaaa gctcacgatt tggctcattt cagcggacat atttcacttt 2324581 aaccgataat ctgccccatt aaacctgccg ccagcatttc ttataggacc gtccataaaa 2324641 agtaaccgat catcaaaagc tgtatgatgc cctttgcaat aacccctgtt aaaaaaccaa 2324701 tgagtgagcc gaggccaatt ttaaacgctg actttaagtc cttctgatgg acgataagtt 2324761 ctgcgcaaac agccccgata aacggcccca atatgatccc tgcaaccgga atgacaaaag 2324821 gcccgattaa taaaccgatc gtgcttcccc atatggcagc tttgcttcct ccgaaccttt 2324881 ttactccaag cagattcgac acgtaatctg ctgcgaataa tactgcggca aaaactgcct 2324941 caacaagcca gaacatataa gaatacggac tgaatgaaaa taaaaatccg tacaatacaa 2325001 atccggcaac aataaatact acgctaggaa taacaggata caccagcccg ataaaggcaa 2325061 tgataaaaac cgctgcaatc aacagccaat acaacatatc catagcttcc atcctcccat 2325121 tttactctgt cttcttcatg tcttccttgt attcacacgc atgcaacgat acaataagca 2325181 acatatatta gtttagctag gaagtgaaga tagtgaatgt gtttcagctt ttcattaaaa 2325241 gtacatactc tccccgtgat attgcaaaaa caagatttca aggaatcgga aaagcgattc 2325301 tttatgtatt tttgctctct gtcctgtttg caatccctac cgcttattat gtaagtacag 2325361 ggaccgtaaa atcaatgaac ggctttaaaa ctgttttaaa caaagatttc cctgatttca 2325421 caatttcaaa cggcaaactt caaacggatg agaaaaaagc cacggaatct caggcaaatg 2325481 gtttcgttat cgtgttcgat ccgacagact cctatggcac tgaacaaatt gaagcaaagc 2325541 aaaacgcaat cggcatcctt cagaacaaat ttgttttggc cattgacgga caagcccaag 2325601 aaatgtctta ctcaatgatg ccgtcagagt tacagaaaaa agatgtcatt gcaggtttaa 2325661 accaaaataa agcgatgatt gtaactgttc tctcagctct tatttttctc gtaacagcag 2325721 cgggaaaatt tattgaagta tcgtttttag cgcttatcgg gttaatcatt aagaattcgc 2325781 agaaaaaaca tttatcctat catcagctct ggaagctttc tgcttattcc atcacacttt 2325841 caactgtatt ctttacaatc atgcgggcac tagaagcaac cgtaccaagt gaatttttgc 2325901 tgaactggtt tgtcaatttt gtcatcctgt ttctcgtttt aaaagagatt ccgtccaaaa 2325961 aagtaattaa taaaagttaa attatattta tttttatcct ttaagtagag agtgtgaaag 2326021 catttgcatt aactttttac ttaagggata tttaataaaa tgtatagagc ttaaacagat 2326081 acatttataa aaaaagctct acaattactc aagaacaagc tctggacaat aatatcagaa 2326141 gtagtaagat gtaacatgaa agaagttctt aacagcattt gacatatgtt tttaacaaaa 2326201 taagaataat gttaaatttt aactaataga ctagttaaaa tcatatggca aaatattttg 2326261 catcctttca caacatattt acataagata gttgctattt aaaaagccag gtaccaatag 2326321 ggcacctagc tttcagaatt aaatcatcaa caagttagaa ttatcttctt tccttctatt 2326381 ctcattattg aactgttatc ttttttgtgg gtttatgtat acaaatgcag ctcccttagc 2326441 tttcccctta tatactgata aacctactgc ccaaggtgtt cctgtcggtt ttggtaattt 2326501 actgaagtaa aactttttgg ttggagttct acttgaaaag taccctgaat attgcgggcc 2326561 aatgtcccca ccctcaacta tagatacacc aaagctctta taatttagtt taccgcattt 2326621 tccatttgtt tcggcgtaag catcaataga tgttgcactc ttagtatatg tataagcatc 2326681 tgtaataact cttattttac aaccagaaat accacttacc ggttgccaac cactgcttgc 2326741 agcctctgct ttttctttag gtgcaactac caaagttaac attagtagca aaattaaaaa 2326801 cacagaaaat tttccttgct tcattttgta gatcctcctt taaactatta cataattatc 2326861 ctaacagatc cattgttcat tgtaaataat ggaatacgag ttttatatta taaaagcctc 2326921 tttttgatct aattttgcac tattttctat tttctatctg aagttaatgt ttagtcgaag 2326981 aaatcctgtc aaaaaagcgc ctgtataaaa accgagcatt cgcagtctct tttcttttgt 2327041 catgaatcga aatggacaag catactatgg tataaaattt cgtatgcggg aggaaaagcg 2327101 atgaagcgtc tcaccttagt atgcagcatt gtttttatac tttttattct tttttatgac 2327161 cttaaaattg gaaccatacc cattcaggac ctccctgtct atgaagcatc agcaaaaacg 2327221 gctgtacaag aaccggctta taaaacggtg aaggtaaagc cgggtgatac ggttatgtcg 2327281 atagtcggat cagcaggttc tccggatgac attgtaaagg attttgaagc actgaatcca 2327341 aatgtgaaag ctaacgccat tcaagccgga acagcgtata aattcccggt ctacccttaa 2327401 tttaacgtta atttcttgtc agttcggcga agacactgtt acaatgtaat ttgtaaaata 2327461 aattcacata aaccatacta gaattgttat atctagaagc ggcaactaca attaaggagc 2327521 gattgcaagt gagtgaaatc acacatcgta caaaaacgcg tcccgtcaaa gtgggacctt 2327581 taacaatagg cggcaacaat gaagttgtca tccaaagcat gacaacaaca aaaacacatg 2327641 atgtagaagc aacggttgcg gaaattaacc gtttggctga agccggatgc caaatcgttc 2327701 gggtagcatg tccggatgaa cgggcggcaa acgccattgc ggatattaaa aagcgcattt 2327761 ccattcctct cgttgttgac atacatttcg attataaact tgcgttgaaa gccattgaag 2327821 gcggcgcaga taaaatccga atcaaccccg gcaatatcgg ccggcgcgaa aaagttgaag 2327881 cggttgttaa agcggccaaa gacaaaggca ttccgatcag aatcggagta aacgccggtt 2327941 cattggaaaa acggatttta gaaaaatacg gttatccgac tgccgatgga atggtagaaa 2328001 gcgcacttca tcacattaaa attcttgagg atcttgattt tcacgatatt attgtcagca 2328061 tgaaggcctc tgacgtgaac cttgcaatcg aggcttatga aaaagcagcg aaagcgtttg 2328121 actacccgct tcacctcggg atcaccgagt caggaacact gtttgccggc acagtaaaga 2328181 gcgcagcagg actcggcgcc attttaagca aaggcatcgg gaacaccatg cgcatttcac 2328241 taagcgcaga ccctgtagaa gaggtaaaag tagcaaggga gcttctgaaa tctttcggct 2328301 tagcctccaa tgctgccacg ctcatctcat gcccgacttg cggccgtatt gagattgatc 2328361 taatcagcat tgccaatgaa gtggaagagt atatttctaa gataaaagcg ccgattaaag 2328421 ttgctgttct cggctgcgct gtaaacggac ctggtgaagc gagagaagct gatatcggaa 2328481 tcgccggcgc acgcggtgaa gggctgctgt tccggaaagg gaaaattgtc cgtaaggttc 2328541 cagaggaaac gatggtagaa gaactcaaaa aagaaattga cattcttgct gaggaacact 2328601 acgcaaaact tgaagctgaa aaagcaaaat taaaagaaga aacacaaaaa gcttgacggg 2328661 aacccgtcaa gcttttttgt gttagaaaaa tggaataata aatattccaa gcactaatga 2328721 aacgacaccg atacccattg cccaggctcc aaggccttga gcacctcttc ttcttgcgat 2328781 atagccgaca ataataccag cagctcccaa taaaacaggc agtacaaaca atgaaatgat 2328841 ggacaaggct aaagcgatgt accctattcc ccgtccttca ttgacattgc cgccgctgcg 2328901 atcattgtct tggtcattgc tgcggtcagc agcacgataa ggctctgcga tttcagcagc 2328961 tgtttcctca aaaaaaccgt cattgtcgcg ggtaatattt gtcccttcag atccatgatc 2329021 aacatagtaa ctgttgttat cacgcttttc gtaatcgttt gccaccttca attccccctt 2329081 ctgttttatt aaaggagctt ttatagtttg atccattttg cctgattcat gtttgctaaa 2329141 cttttctgtt aatgtcaatt gtttatgtta cacttgaagg gatgaaactg aaggagtgtg 2329201 ggcatgttac gcttaggaat agatattgac ggcacaatca cggctcagga tacattcgtc 2329261 ccttatttga accgttcgtt taatctttcc atttcattaa acgatatgac ggattatgat 2329321 ttaacaaagc tgttaaacat tacccaggaa gaattttggg attggatgaa tcaaaatgaa 2329381 gcgatcatat ataaggaagc attgcttgca cagcatgcga aacagtctct cgatcttctc 2329441 aaagaggagc acaagcttat ttatattaca gcgagacgga ctcatttaac tgatattact 2329501 tatgaatggt ttgacagaca aaacattcat tatgaccaca tcgaacttgt tgggggtcat 2329561 cacaaagttg aagcggtcaa gaatcataac atcgacctgt tttttgagga tcatcacggg 2329621 aacgccatga tgattgcgaa agaagccggg ataccggtga ttttgttcaa ttccccttat 2329681 aatcagcttc cgattgattc aaacatcatc agagtaaaca actggctaga agccgttcaa 2329741 tggatgaaca acaacaagca tcacttaata cgcgtcaata actgaaaaag gagcccaaac 2329801 cgggcccctt tttcatatat acgcatttta cgcagtagtg ttttcttggt tttccgctgt 2329861 acaatcaggg catgtgccat aaatctcaaa tttatgcccg ctgacctgat agccatccaa 2329921 atcatcacaa agcttgtcca tcggacatga ttcaatttcc tttgttttgc cgcaggcaag 2329981 acaaataaaa tgatggtggt gatgggtgaa tgaacactta aatcggaaga gcttttcacc 2330041 ggacagctca gttgtttcca aaatcccaag ttcttcatat aaagaaagat ttctgtagat 2330101 tgtatcaaag cttaagcctg gataatcatc attcagtgca gacagtacgt ttttagcggt 2330161 aagatatctg tctgaatcag caaaaagctg cagcatatcc tcccgtttgt ttgtatattt 2330221 atatccgttt tcttttaata ggttcagcgc ttcttggacg ttcatgaagg gtcccccttt 2330281 tcgctttgct taagaacgta tcacatgtat gaaaaagaaa atggcagctg tctgtccagc 2330341 aagccatttt ctttactgca gataaaatta tacccataaa atgaataaaa gtaaatgaaa 2330401 gcctagtgga ttgcgttttt gaattttccg cctctcgttt catgagtatt cataattgtt 2330461 atgaatgcat tttgatcaac ttcaaacacg atcgatttga gctttgtcac ttccagcctt 2330521 gtgacaaccg cgtaaattac gtctttttct tcgtccgtat acccgccttt ccccttcagc 2330581 ttcgttgtgc cccgaccgag acggtgcaaa atcgcgtcgg aaatctcatc atactgctca 2330641 gacacaataa tgacagcttt tgtttcatca agcccttgga tcacggcatc aatcgttttc 2330701 atcgcaatat aataagtcat gaatgagtac atcgcttgct caggaccgaa cacaaaaact 2330761 gcccaaatga aaatgaacac attgatgaac ataacgaact cacctacaga aaacgggagt 2330821 tttttggtca gcaaaatacc gagaatttct gtaccatcca ttgaacctcc atttcgaata 2330881 acaagcccga cgccaaagcc gagtaaaaga cctccgaaca cagtagccaa aataggctgg 2330941 gttgtaatgg cttctacatg gtgaagtgag gattcaataa cggcaagccc gacaatccct 2331001 ataaacgtag agactagaaa ggtcttaccg atatatttat atccgaagat cataaaagga 2331061 atatttaata tgacaacgaa aaaagcgaaa ttcagaaagg ggtttgacat aaagaggtgg 2331121 tctaaaataa gagatacacc gataatcccg ccatcaataa aatcattggg gattaaaaat 2331181 aattcaatac ttacagccgc agatgcagct cctaccagaa tcataaagac cctgaaaata 2331241 aaatgggtaa atgtttcttt cttatgttgt tttgttgggg tcataaaatc tcctttcctg 2331301 caataactat tttaaataca ttataaatct attttaccat taaacactga cacattttac 2331361 tgatttgccc atacattaag tctggaggtg gaatgaccga tgattttatt tcaaagaatt 2331421 attttgcagc ggcttaatca ggctactgct gatgatttgc tgaagtactc aaaacaatac 2331481 ggaatcagct taacaagatc gcaggccgtt gaagtagcga acctgttata cgggaaaaat 2331541 gtaaacatct ttaatgagag tgaacgaatg cggctgctga aacaagtaga gacgattaca 2331601 tcgaaagaaa cagctcaaac agttaatgaa ctattcaaac aatttacaag ctaaaaaatg 2331661 ggggtgttat cccccatttt ttattgctgt aaaatctttt caagcaatgt atcatcaaat 2331721 tgtttttctt tcagcatttc aatctcaaaa cggtatggcg gttttttgtt ctttttatct 2331781 tcaccgacgt atggtgtttc aagaattttt ggaatgtctt ttaactgctc atggtgaaca 2331841 acatattgca gtgcgtcaaa acctatttca ccaaagccaa tattttcatg gcggtctttt 2331901 ctcgcacctt tgacattttt gctgtcattg atatgaagca ctttaatacg gtcaatgcca 2331961 atgattttat cgaactcatt tagcactccg tcaaagtctt cgacaatgtt atacccggca 2332021 tcatgtgtat ggcacgtgtc aaagcacact gacagctgct cattgtgtgt aacgccttcg 2332081 ataatctgcg caagctcctc aaagcttctg ccgcattctg atccttttcc agccattgtt 2332141 tctaatgcaa tctggacatt ttgattcgga tcaatcactt catttaagcc ttcaataatt 2332201 tttttgatgc cggcttcagc tcctgcccct acgtgagcgc caggatgaag gacaatttgc 2332261 ttcgctccga tggccgctgt ccgttcaatt tctgaacgaa gaaaatcaac acccagctca 2332321 aaagtggacg gatttgtcgt gttgccaata ttaataatat aaggcgcgtg tacgataatc 2332381 tcgtcaatgc cgttttcttg catatgtgcc cggcctgctt ctatatttaa gtcttcaatt 2332441 ttctttcggc gcgtattttg cggtgcgcct gtatagatca taaacgtatt cgccccataa 2332501 gagactgctt cctggcttgc agccagaagc atatgttttc cgctcataga gacgtgtgag 2332561 cctattctca gcaacaggtt cccctacttt cttttcttag attggtttct tctctgtttt 2332621 ttcttgattt tctccatctc atagctcatt ttctttttat acccaggctt aaccttcttc 2332681 ggctttttca cgagacgatg agcaatttca tccgcttcat tcggcgtttt tttacgtttt 2332741 ttgcggcgct gacggtcatc gccttttttc cattcgccct tttcaagctc taagtactca 2332801 aattcgatgc ccattttttc aagtcttact aatgcatcct catcagtaag ctcataaatg 2332861 gtcatcgctt gtcctgatga gccggcacga gccgttctgc ccacacggtg aacatagaaa 2332921 tcgagatcat ccggcagctc atagttgata acatggctga cacctttaat atcaatacct 2332981 cttgcggcaa ggtcagttgc aatgatatat gtgaattcca aatcattgat ctgcttcatg 2333041 acttttttcc gctcacgtgg tgttaatccg ccgtgcagca agccgatttt catgcctttg 2333101 ccagtcagat actgggcaat atggtcagcc gtatttttcg tgttggcaaa cacaatcccc 2333161 aggtatggat tcagatgcga catgatgtca aaaaggagct tgtccttgtc acgatgtttc 2333221 gaaggaatga ggatatgctc gattttcgca gcagtcacct gttttggctc cacatgggcg 2333281 tatttcggat tttccatgta tttcttcaag aatggtttca gcttttccgg tatggtcgct 2333341 gagaacacaa gcatttgcag atcctcaggc atgcgggaac cgatgtaatc tacatctgca 2333401 aggaatccca tgtccagcat taaatccgct tcatcaataa caagagattc cgctttatga 2333461 acacttaacg cctgttcttt gattaagtca gcaatccgtc caggtgtacc gacaacaaga 2333521 tgcggctgta ttttcaattt atcaattgat ttttgtttat cagtgcctcc gataaaacat 2333581 ttcgagcgaa tctgacttcc ttcttcaccc tgcgtgattt taagcgcttc ctgataaatc 2333641 tggttggcaa gctctcttgt cggagccgta atgactacct gaacgacatc cttagcagga 2333701 tcgattttgt ttaataaagg cagtaaataa gcgtgagtct ttccagtacc cgtctgagac 2333761 tggccgatga cgctttcttt ttttaacact gcaggaatca gccttttctg gatatcagtc 2333821 ggttcgtaaa aaccaaggcg atgtactgca tctataataa atggtttcaa ttcataaagt 2333881 tcaaatttcg tttctttcat ttttcccagc tccttaaagc ggcacattat gtgtccatca 2333941 tcacattata cccgattttg cttaaaaaca ccacgtttgc aaggcgtttg ttttattcag 2334001 ttatgtaaag caaataccgc agcccatgca tattctaata gcagagagag ctgaaaggag 2334061 gtacaagtat gttttcaccg cagcagccaa tgagaaatta cccacagccc ggaccgcccc 2334121 gccccatgcc aaatcagcga atgatgggca gaagaccgcc taatatgcga ggaccttcat 2334181 ttggagcaca gcagcaaggt tttcagcaag ccggacaatt tcttcctcag gcaaatgccg 2334241 gagcgagaaa tggtgcaggt gcaggcggag gcttaaaagg aatgctgtca aggttcctcc 2334301 ccggcggagg aggcgctggc agcgccgggg ttcccggaat tccaggagca ggtgcagcag 2334361 cgagcggagg tgctggcctg caaggcattc aaaatattgc caatcctgca tcattatcca 2334421 gtatgcttgg aaatgtgcaa aaagtactcg gcatggcgca gcaagtcacc cctatgatcc 2334481 agcagtacgg cccattagtc cgcaatctgc cagcaatgat gaagctgtac agccaattaa 2334541 gtaaaagtga tgatactgag acagaggcca atgaggaaag tgaaaaacaa tccgtttcag 2334601 aagaatcatc agaaaaagaa aaagagactg aaacaaaaac ctcagatggg aacaaaaaat 2334661 caaaaccaaa aagttcttct ctcccaaaga aatctaaaac aactgacaat aaagaacaag 2334721 aattaaaaac atctgccccg aagaaaaagg aagctgcctc tcctgctccg aaaagaacat 2334781 caggcagttc aaaaccgaga ttatatattt aacattcttt gatatcttaa gtgagattgg 2334841 ctataatgag atcagaagaa tgcaagaata gagccgtttg attacggctt tttatattgc 2334901 ctttactcac ttcagtattg gaggacaacc gaaaatggac gtaattaaaa tttcaccgcg 2334961 cggctattgc tatggtgttg ttgatgctat ggtcattgcc aaaaatgcgt cgctagataa 2335021 aagcttgcca agacccatct atatactcgg gatgattgtt cataataaac acgtcactga 2335081 tgcgtttgaa gaggaaggga tttttacatt ggacggctct aaccgtctgg acatcttaaa 2335141 gcaggttgac aaaggaactg tcattttcac tgcgcacggt gtttctcccg aagtcagaag 2335201 aatcgcagaa gaaaaagggt tagtcgcaat tgatgctaca tgtccggatg tgacaaaaac 2335261 tcataatcta atcttagaga tgaaagaaaa aggatatcac gtgatctata tcggcaaaaa 2335321 agggcatcca gagcctgagg gagccgttgg cgtagcgccg gagatcgttc acttagttga 2335381 aacagaagaa gatgtaaaga accttgatat ccaatctgag aagttaatcg tgacgaatca 2335441 aacaacaatg tctcaatggg atgttcacga cattatggag cttgtcaaag aaaaatatcc 2335501 tcatgtcgaa tatcaccaag agatttgcct cgctactcaa gtgcggcagg aagctgtatc 2335561 agagcaggca aaaaaagcgg acttaacaat cgttgtcgga gacccgaaaa gcaacaattc 2335621 aaataggctt gctcaagtgt cagaggaaat agccgggaca aaagcatacc ggatcggcga 2335681 cttaagcgaa ttgaagctcg aatggctgaa aggcgttaat accgttgcag ttacagcggg 2335741 agcttcaaca ccgacgccga tcacaaaaga agtcattcgc tttttagagc agtttgatca 2335801 cgaagatcca tcaacttgga caactgaaca taatataccg ctcaaaaaaa tacttccaaa 2335861 agtaaaagca aaaaactgag gctgtaaaag cctcagtttt tttatagaaa tgtaaatgga 2335921 tttgtatctg tttcagaaac aaagatattc acgccaaact ttttatcatt acacattgat 2335981 gtaagttttc tcgtgacgcc ttctttcatg attttttccg cgtaatggcc cggatcaacc 2336041 acatttaggc caagcatcat cgcatcatgg gccacatgga agtataaatc tcctgtgacg 2336101 taaacatcgg ctccctttcg ttttgcatga tgaatatact tgtttccatc tccgccaaga 2336161 acagctactt ttttcaccat gctgtcagca tccccaacca ttctgacacc attgacgtca 2336221 agcttgtctt tcacaaataa agcgaattcc ttgagcgtca tctcattttt aagggttccg 2336281 acacggccga gccctttttc ggcgggagtc tgttcgacag gatagatatc gtaagcgact 2336341 tcttcatatg gatggctttt tatcattgca ttgataacag ccttttcgac gcttttagga 2336401 aatacagtct caagccttac ttcatgaaca agctcaagct ctcccacttc accgataaaa 2336461 ggcttagctc cgtccaatgg cttaaagctg ccgattcctt cagatgaaaa cgcgcaatgg 2336521 ctgtattcac cgatatggcc ggcccccgca tttccgagcg cggctctgac ctgctcttca 2336581 tattccttcg gcacgtaaac tgccagcttt ttcagaggat ccgtataagt aggtgccagc 2336641 acttccgtct cactcagctc taatgcttca gcaagcaaat cattcacacc gccgtccgca 2336701 acgtctaaat ttgtatgagc tgcataaaca gcaatatcat gcttcaaaca cttttcaatt 2336761 aaccttccgg caggctgatc tgttgaaata tgctttagcg accggaaaat tggtggatgg 2336821 tgtgcaataa tcaagtcaac ctctttttca atcgcttcat cgataacgct ctctaacaca 2336881 tcaagtgtaa ccatcacatt tttaattggt ttgtttaagg tgccgatttg caggccgatt 2336941 ttatctcctt caaccgcata ggctttcggg gaaaattgtt caaacagctg gatgatctgc 2337001 tgcccattta cacttttagc catgatcgat tacctccttt aacagctcca ttcgatcggc 2337061 gagctccttt aatttttgtt tgttttgctc tgtatccgcc gcttggctga tctgttcata 2337121 aatgctttga gtgtgctgaa gctcttgtgt ccactttttc aaaaagacag catttttttc 2337181 ttttgccaag aaagggccaa cgagcatccc ggctgataaa gaaataccgt cataagccgc 2337241 atccctgtct cccgcttctg ccaccagcac ctcatagcac tttccgtcct cttcaaggat 2337301 tacctcatct atcagcgcat atctttcttt ataaagccac tccctgatat gaacagcatg 2337361 aatattcggc tgtaaaatga gccgttcctt ccccgttaat ttgtctttgc ccgcttctaa 2337421 aatgtgagcg atcaaagccc cgcccattcc ggcaatcgta atggcatcag cttcaccttt 2337481 tttaatcact tccagtccgt ctccctgcct tacagaaatg tgcgagttta agcctgattt 2337541 ttcaacctgc cgctttgcag acaaaaatgg gccgtctgtt atttctccgg caatcgcccc 2337601 gctggcttta tgattcagca ccgcataaca aggaaggtag gcgtggtcag agccgatatc 2337661 ggccatcacc gctccattcg gtatgtactc cgctactgtt tgcaatcgtt tagataattt 2337721 taattcgttc acttgtcatc acaacttttc tcaatcattt tttcctttac tatcatataa 2337781 aaaatcagcc cggaatccaa gctgaagcaa atgattttga aattatttct tttgatgcgg 2337841 gtctgcacgc agcagtcaaa aataaaaggc tgtcgagaac atctcggcgg cctgtgaatg 2337901 tataaagaga aaaatagttc ttttatttaa tttttgacac ccactctgcc atatcatcca 2337961 gcttatcggc cggaacaaga ccggaaggca ttccattacc gcctttttcg atctttgttt 2338021 taatttcagc gacatctttc ttatccccta caccttttaa gctaggaccc gaaacacctt 2338081 cataattttc accgtggcat gcgatgcagt ttgccttgta aatttcttct ggtgaagcgt 2338141 ttgcatcttt cttttcagca gatttgcttt ctcctccgct cgcaatctcc cgagagtcat 2338201 caagtccttt tactgataaa aagaaagtta gaccaattcc taaaacagcg atcagcaaaa 2338261 atggaataag cgggttccat ttcatttccc ttcccccttt ttgatccttc cccctatgta 2338321 aacacttcta attctaactt atttttacaa aaagtaaatg gattgctata caaaagtttt 2338381 ttattcacac tttatacaaa attgaataga aacatgccta aatctctaat atccttttta 2338441 ttctattgta taatgtattg tatacgctta caatagaaaa tatggaatta gattttgaaa 2338501 tttttcacca caatgttcat ttgcaaatga catcattttt cagtaaaata aaggcatatt 2338561 atccatatat ctttttaaaa aaagaagaac ggatcttcaa gacccgttcc atcttattca 2338621 aggaaatctt tcaaacgttt acttctgcta ggatgtctta gtttccgcaa cgctttggct 2338681 tcgatttgtc gaatacgctc tctcgttact ccaaatactt tgccgacctc ttctaatgtt 2338741 cttgtacggc cgtcatcaag accgaatcga agacgcaata cattttcttc acgatcagtt 2338801 aacgtatcaa gcacatcttc cagctgctct ttcaatagct cgtatgcggc gtggtcagaa 2338861 ggtgaagttg cttcttggtc ttcaatgaaa tcaccaaggt gcgagtcatc ctcttcaccg 2338921 atcggtgttt ccagagatac cggctcttga gcaatcttta agatttcgcg tactttttca 2338981 ggcgttaaat ccatatcttc cgcaatttct tcaggtgttg gttctctgcc taagtcttgc 2339041 agtaattgac gctgcacacg gattaattta ttaatggttt caaccatatg aacgggaatc 2339101 cggatcgttc tcgcctgatc ggcaatggcg cgtgtaatcg cctgtctgat ccaccacgta 2339161 gcatacgtac tgaatttata acctttgcga taatcaaatt tttcaacggc tttcatcagg 2339221 cccatgtttc cttcctggat cagatcaagg aacagcatac cgcgtccgac ataccgtttt 2339281 gcgatactga caacaagccg caggttcgct tcagccaatc tgcgtttaga ttcttcgtca 2339341 ccttcttcaa tcttttgagc gtaggcgatt tcttcttttg cagaaagaag gttaacccga 2339401 ccgatttcct ttaaatacat acgaactggg tcattgattt taacgccagg cggtacactt 2339461 aggtcattaa ggtcaaattc ttcttcggct ttggcaagct gctgaatatt aggatcttct 2339521 gtttcttcat tctcactaat taattcaaca ccttgttcac ctaaaaattc ataatactca 2339581 tccatttggt ctgattcaat ttcaaagctg gacatacgct cagcaatttc ttcatatgtc 2339641 aaaacgccac gttttttacc agactctgtt aattgctctt ttacttggtc gaatgttaat 2339701 tctgtctcgt gggtttgttt atcagccatt atggatccct ccttccaaag cttgcaacga 2339761 attctataag cggtatgatt cttattcggt ccattcaggc gttttctatg tgaactgcct 2339821 ttaacaatgt gcgaataatg aaatgacaat tcatgatgag gttaagcgat ctatttgctc 2339881 ctccgcaagg aatcattgcc aataaatgct cctcatcagt tctccagtta ttttaaagat 2339941 cggttcaatg taacgatttc ttgagccaaa gaagcagctc ttaaaaaatc tttttgcctt 2340001 tctgcttcgg ctctttccgc ctctttttct tttatcattg accaatttct ttgattcaac 2340061 acttttttta cataatctga taactcggct tcgctaagct cttgattaac ctgaagcatt 2340121 aatatatcgg acaagagctg gcttatatga tcatccgtca ccctggccat cagatgctga 2340181 ggcgtcagct cggctccctc ttcataaaaa gcataaagat aagcggctaa tgcccggtgc 2340241 tcatcaatat taaattgaaa ccctacccgg tcaatcactt ttttgatgac gctccgatct 2340301 cgaagcatgt gagcgagtaa cagcctttct gcattttcat acgccggacg caaacgtttt 2340361 tgccttgctt ttgtcgtcag atgcgctcgc cgcgttttag tttcaccgct attgtcagca 2340421 ggtttgtttt gcttgctgaa aacagacagc tgctcagtta aagactcctg tgaaagcgaa 2340481 aactctgaag caagctgctt tacatagact tcctgctcta gagaccctga aagcgtgctg 2340541 atttctttca gtacgtcttt aatgtaagct aggcggtcgc cttcatcgga caggttcttt 2340601 ccttttcgga aatattgcat tttgaacgcc attacggtga cacttgcgtc aataatgtcg 2340661 tttttaaatt tttccccgcc gaattttttg atgtaatcat cagggtccaa tccgtcagga 2340721 atcattgcaa ctctgacttt gcagcctttt ttttgcagaa gctccgaagc ttttaaggtg 2340781 gcttcataac cggctttatc agagtcatag caaagaatga tttcttcgac gtttcttctc 2340841 aggatcttga catgatcatc tgtaagagac gttcccatcg tggctatgct ttcctttaca 2340901 tccgagctta cggccgatat gacatcagca aacccttcaa ataagactgc tctttcctgc 2340961 tttctgatat gaaggcgggc cttataaaaa ttgtaaagca gtttgctttt atgaaagagc 2341021 ggggtttcag gactgttcat atacttaggc tgctggctgc caagagccct gcctgagaaa 2341081 gcaacaacag ccccgtgatg atcatggatc ggaaacatga cacggtttct gaagcggtcg 2341141 aaatatccgc ttccgtcttc gcgtctgatc aggagacccg ctttttccat ttgcgcctca 2341201 ctaaatcccc tctttacaag gaatttcgtg ataaagtccc aagaatcaag agcatagcca 2341261 atctgaaatt cattaatcag ctctttcgta aagcccctag aaagcagata atccagtgcc 2341321 tcttgacctt cttttgtatt tattaacaaa tgatggtaaa atttcttcag gagctcatgt 2341381 gcctcagcca ttttttgttc tccagaagac tctggccggg ctccggaatg gactgttata 2341441 tcatctggaa aatcaatttg gtatttgtca gcaaggtgag aaaccgactc ggcaaaagaa 2341501 tagccttcca tctgccttaa aaaagagaaa acattgccgc ccgctccgca gccaaagcaa 2341561 tgaaaaatct gtttgtcggg cgatacggaa aacgaaggtg tgctttctcc atgaaaagga 2341621 cagagtccaa agtagtttcg gccttgcttc tttaattgaa cataatcacc tatgacttca 2341681 acgatatctg ccgacttttg cacctgatcc acaatttcat ctggtatccg atttcccatc 2341741 ttataacact ccgtcgtaca ttattcgatg ctttagtgca aaatcccttc atcgttcgac 2341801 aggatttttt gcagcagtgt aataaatcgt tctcgatctt ctttattcaa ttttttaggc 2341861 cctttggcat atacgccttt tcttctttgt ttgccggaaa aatgacggcc ctctagggca 2341921 aaatcaatcg tgtcttcctt gtaaagacga cctctttccg acataacaga gacatttctg 2341981 ttcaacagca gagatgctaa tccgatgtcc tgcgtcacaa caatatctcc cggtttcacg 2342041 tgatttgcga tatataaatc agcagcttct ttatgaggat caacatactt ccatttttct 2342101 tcattgcttc tggaaagctg ataatgttca aatgaagcga caaaaagaac ttgaacttca 2342161 tactcggatg ctgtttgtaa aatttcatct tttaccggac aagcatcagc atcgacaaaa 2342221 atcgtctttt cttgttcatt aagaagagta attctccatc cctccattaa actcctgcat 2342281 aaaagcaagc aaaatcgcac atcctttatt attgtggatg tatatgaatt tgtcgaaaaa 2342341 tttccgggag aaattcttga catcttaccc ataatagttt attcgtatca cacgatcctt 2342401 aaacctaaaa ttaatcattt tatcacaatt ttttattata atacaaactt cacaaagatg 2342461 ctattgtttt tcattattcc cttttggcac agccaaaaac ccaggataga gcgtcctgag 2342521 ttatatgttt tttgttttga gatgatggat aatatttgct gtttcctcaa ccgctttatt 2342581 tgaaacatca acaacctggc agccgatccg atccacaatc ttttcgaaat actcgagttc 2342641 ctctttgatt ctgttgatat ttgcataaat cgctttatca ttaagcccga gtgattttaa 2342701 acgttctttt ctgatatgat tcagtttatc agggctaatc tttaaaccga tgcatttttt 2342761 cggatcaacg ttaaagagtt cttccggcgg atcaacctcc ggtacaatcg gaacattggc 2342821 aaccttcagg cgtttgtgtg cgagatattg agacagcggt gttttagacg ttcttgacac 2342881 gccgatcaaa acgatatcag cttttaaaat ccctcttgga tcacgtccat catcgtattt 2342941 aactgcaaac tcgatggcct ccactttttt gaaataatct tcatcaagct ggcgcacccg 2343001 ccccggttcg tatttcgctg ttaaaccgta ggctgtttcc attttatcaa tcaacgggcc 2343061 gataatatca taatataaaa catttgcttt ttccgcttcg gctatcaaat attctctgat 2343121 ttccggcacc acgagtgtaa aacagataat gccgccgtct gcctttgcaa gtgaaatcac 2343181 ttcattgata gtgcctatat cttcaacata aggaattctt cttacatgag tatcatccgc 2343241 cgatccgtta aattggctga gtgctgcttt tactaccaat tcagccgttt caccgacgga 2343301 atccgataca acatagatga tgcggttatt catattatcc ccccgttagt ttgcaatctt 2343361 ataggatttc attttcagat aaactgacaa gtattttggt catatttgtt tttgtcactc 2343421 tgccgatcac ttcaaagcct ttatcggtgt ctttgatgac aggcagtgca tcaatttgtt 2343481 tttctattaa gtgctttgca atgtccatca cataatcctc gcgtctgcac accgtaatgt 2343541 tcggcatcct tgtcatgatg atgtgaacag ggaccgatgt aagctcctgc tggccaatgc 2343601 tcgctctgag caagtctttt cgtgaaagca ccccgactaa aacagcatcg cggtccacca 2343661 caaacagagt acctacatct tctaaaaaca tggtgcaaat cgcatcgtac acagaaacgt 2343721 tttcgtgaat cactacgggg atagattgaa agtctttcac ctgaagcttt ttgagtttat 2343781 ccgccaaaag ctgtgtgccg gtttttcccg tatagaaata accgactctc gggcgcgcct 2343841 cgaggaatcc tgacatggtg agtatggcta aatccgggcg caatgtcgcc ctggttaggt 2343901 tcagcttttc tgcaatatgc tcccctgtaa tcggcccgtt ttcttttaca atctgcaaaa 2343961 tatgttcttg ccgtttattt agttcgatcg tactcaccac cttttcactt catagctatg 2344021 taaagaaata acaatccata ttataacgta aatatcttgt aatcaaacaa aaaacttata 2344081 aatggggaaa agacgattac cgatcacaca gcaaccgcct tttctctctt tattttacaa 2344141 taagggcatt catattcgca aaggacttga tctcatccgc caagcttacc atttgcgcta 2344201 aacgatttgc ctttaatgac tcattatccg ctataaccat tgtatgatcg aagtaagcat 2344261 cgatcggttc ttttaaggct gcaagtgaag caagcgccgc ctcataatct tttttgctga 2344321 agttttcctg cagattttgc ttcgctgttt ggtaggcatc aaacagtttt gcttcgtatt 2344381 cattttcaaa cagatcaggc tgaatgtctc cgcggactcc ttttttgctg atagagatca 2344441 ctcggcctaa cgcttcggct gtttccttaa agccaggtgc accaagcttt tgctccagta 2344501 cttgtgcttt atgcagcgca gagtacggct caagctcaga gctttccagc acggcgtcaa 2344561 tgacatcatg tctgatttgt tcagcattca agacatattt caagcgctga gtgaagaaat 2344621 ccagcagttc attttcttta tcggtttgaa cgaaagtaag cagctcttca aatgaaattc 2344681 cccagttgcg gtcaagaaga atcgcaacaa taccgcttgc ttggcggcgc agtccgtaag 2344741 ggtcctggga accggtcgga attacgccga tagagaagaa tgaagcgatt gtgtcaagct 2344801 tatccgccat tgctacaaca gctccggtga aagtagaagg cgtttctccg cccgctgatc 2344861 taggcatata atgttcatta actgccgcag ccacagcttc atcttcgcca agcattctcg 2344921 catacttttc gcccataatt ccttgaagtt cagggaattc atatatcata tgcgtcacaa 2344981 ggtcgaattt agaaatttca gcagcccgct tcacatgttt taatgtatct tcatcagcct 2345041 gaagacgaac ggcaagtttc tctgcgattg atgtgactct cctaacctta tcagcaagag 2345101 aaccaagctc ttcatggaaa acgatatttt caagcttctt cacatttgca tcaatgttta 2345161 gtttctgatc ttctttgtag aagaatgaag catcagataa acgtgcgcgc agcacttttt 2345221 cattgcctcg ggccacattt tcaatcgcgt ggctgttgcc gtttcggact gtgataaagt 2345281 gaggcagcag gtcaccgttt ttgtctttga cagggaagta gcgctgatgc tctttcattg 2345341 tcgtgacaag cacttcttca ggaattgaca gaaactcgga ttcaaatgaa ccgtaaagag 2345401 ctgtcgggta ttctactaaa tgattcactt catcaagaag gtcttcgtca actggaatgc 2345461 tccaattgtt ttcagcagcc attgtttcca gctgagattg aatcatttgc tttcggacgc 2345521 taggatcagc aataacatgc tgtcctttga gctgctcttc ataagctgaa ggtgattcaa 2345581 ttgacacttc atgtccgagg aaacggtgtc cctgtgttgt ccgtccagac tcaacgtttg 2345641 tgatcgaaaa tggaatgaca tcctgtccaa ataatgcgac aatccatttg atcggtcgga 2345701 tataacgcaa atcttcattt ccccagcgca tgtttttcgg gaaatgcaag cttgtaatta 2345761 aaccgctcaa ttctggcaga agcgacttcg tttcttggcc ggcttggaat ttttgcacga 2345821 atacatactc tatgcctttt acttctttga tgtacaggtc ttccacattt gcgccttggc 2345881 cttttgaaaa gccgattgcc gcttttgtcc agttcccgtc cgcatcaagg gcaatttttt 2345941 tcgcaggccc ttttgcttct tcttttatat catcctgctt ttctgcgaca tccttaacga 2346001 acacagcaag acgtctcggt gtattgaaga gtttcacttc accgtgagta atattttttt 2346061 ctttaagcca gcctgtcagc ttgtcgccaa gctgaaccat gctttcattc aaaaagcgcg 2346121 ccggcatttc ctctaatccg atctctaaaa gtaaatcctg tttactcatg agaagaaccc 2346181 tcccctttaa gcattgggaa ccctagtttt tctcgttcct catagtaggt ttttgctact 2346241 tttctagcta aattccgcac tcttgcgata tagcccgtcc gctcggtaac agagatcgca 2346301 cctttggcat caagcaggtt gaaagtgtgc gagcatttca gcacatagtc atatgctgga 2346361 tgaacaagtc cgttgtccat ttgcttgatc gcttcttttt catatgtgct gaacaattgg 2346421 aacagcatat cgacgtctga tgtttcaaac gtataaacag aatgctcata ttcagccatc 2346481 atgaataaat cttttactgt aaaccctgac gtccattcca agtcaaacac gttttcttta 2346541 tcctggatat aagacgcgag acgctcaatt ccatacgtaa tctctacaga aacgggttta 2346601 cactctaatc ccccgacctg ctggaaatac gtaaattgtg ttatttccat tccgtcaagc 2346661 caaacttccc agcctagacc cgcgcagcct aaagacggat tctcccagtt gtcttcaaca 2346721 aagcgaatat cgtgctcaag cggatcaatt ccaagagcac gcaaggaatc caaatacagc 2346781 tcttgaatgt tatcaggtga cggtttaata atgacctgga actgatgatg ctgatacagt 2346841 ctgttcgggt tctccccgta gcggccgtct gccggacgtc tggaaggctc tacataagcc 2346901 actttccacg gctcaggacc gatactgcgc aaaaatgtat acgggctcat cgtgccggct 2346961 cctttttcta catcgtaagc ctgcataagc acacagccct gactggacca atgcttttgc 2347021 aaggttagaa tcatgtcttg aatattcatt tcaagcacct ccacttttct ttcataagtt 2347081 gactgcggca gcaaccaaaa aactcccgtc tctatgcttg ccagccgcaa acatagggac 2347141 gagagttctc ccgcggttcc accctagttg ctgagaacaa aatcccagcc tcttttttaa 2347201 aattgctcaa gaatgccttt cgttgcgtgc tcatccttag cttacaccgc cctaaggtcg 2347261 ctttcatgag gtaaacgcaa gtacttcttt ctctcactgc aacatatttt ataataaatg 2347321 atcatataaa aagatggacc aaatgtcaac ttttgttttc acccataaga tgtttcatgc 2347381 tttccatttg atctaaaaag cgctttgatt ttaaatacaa tcccgaatat tcttcgtaat 2347441 ataaatcaat cacttgcttt aattcagctt ttgtttcctc ttttaaggac acattgccga 2347501 gtctcgacag atcaaaatag taaaagagcc ttaacagcct tgccgtttgc ggtttaatcg 2347561 gtatcctgta aggatctttt tcaaaacagc ggtggcatat aaaaccatta tcacgaacag 2347621 agaaatgaaa ggttccgtct tggcttttac aatgtacaca atgattcagc tcaggataca 2347681 ggcccatgac accgagcatc ttcatttgaa caatgaaggt gataacatcc ggatctgttc 2347741 cttcattcaa ctgttttaat gattctaata tgaattcaaa taaataagga tttggctttt 2347801 tttcttctgt gcctctgtcg actaactcag caacataggc agcatatgct gttaaaaaca 2347861 agtcttccct gatgcctctc atgctgagga tcatttcccc ctgctgaagc gttccgaggc 2347921 ccgatgtttt ttgcattaag aaagaaccat acaaaaaggg ctggctgact gctgataaac 2347981 ggctgttcgg ttttttggcg cctcgtgcca taacacctat ttttccgtgt tctcttgtca 2348041 gtaatgttac gattttattc gtctctccgt aatcatttgt gcgaagaacg atcccttcac 2348101 attttgtcag catttccgca ccttcctcaa gcaggagcgg ccaagaggtt tataaaattg 2348161 gataatcaaa tcgggctagc tcatcttcta gttcttcggg tctttccatg ttctcttttt 2348221 ccagttcttt aaaaagaaga tacgtatcaa catttcctgt ttgagaaaat acgttccagg 2348281 taaaattcaa cacaagaaac ccacctttct gtagttaaac tagcttacct aaactccaaa 2348341 ttcttacctt tatcttgacc agatgtcctc catttcatgt taaacaaaat ttgctaatgt 2348401 atccctgttc ctgtgagata atgacacaca cgggaagaga ttaatattcg tcctctttaa 2348461 agccaaaatc gcgaagctgg gacattttat tacgccagtc tttctgcact ttcacccaca 2348521 attcaaggta gacacgggag cccaacagtg cttcaatatc cgctctcgct ctttttccaa 2348581 cctcttttag aaggcttcct tttttaccga tcacgatgcc tttctgggaa tcccgctcga 2348641 ccacaatcgt tgccgctacg tgcacagaac cgttgtcctg ccctttgatg gattcgatgg 2348701 ccaccgcaat gctgtgcggg atttcttctc tcgtcaaatg cagcaccttt tccctgatta 2348761 attcagaaat gataaatcgt tcagggtggt cagttacctg gtcactcgga tagaattgcg 2348821 gcccttccgg caaatacgct tcgatctgcg cgagcaaggt ttcgatgtta tttccttcta 2348881 aagcagaaat cggaacaatt tccttaaaag gataacgttt gcggtattcg tcaattagca 2348941 gaagcaattg gtcgggatga attttatcaa ttttgtttac gattaagaat acaggcgtag 2349001 acatcgtctg caatttctca atgatgaatt cgtcgccctt cccgtagcct tcctcagcat 2349061 tgatcataaa caagatcaaa tcgacttctt ttaatgtatt ttgcgccact ttcatcataa 2349121 agtccccaag tttatgctta ggtttatgaa tccctggtgt gtcaataaaa atggtttgtg 2349181 atgtgcctgt cgtcagtact ccttgcacct tgtttctcgt cgtttggggc ttatcgctca 2349241 tgatcgcgat tttttgtcca atgactctgt tcaaaaatgt agattttcct acgtttggtc 2349301 ttccaataat ggatacaaat cctgatttaa agctttcgtt cgtcatgtaa atcctccgat 2349361 gaaaatgcgc ctggcaataa ttcttccaca gtcatttctt ttatttgtcc ttgtaaatta 2349421 gtcagtacga caataacgtc ttttgtgcaa agctcagaaa tcacctgtcg gcaggctccg 2349481 cacggagata ctggtccagg ggtgtcagcc gcaacggcca gcatctgaaa ctctgtatcc 2349541 ccttcagaaa cagctttaaa taaagcggta cgctcggcgc aattgcacat gctgtatgcc 2349601 gcgttctcaa tattgcagcc tctgtacact tttccatcct tggtaagaag agcggctcct 2349661 acttggaatt tggaatacgg cgcatatgcc atatcacgcg cttttaaagc ttctgttatt 2349721 aattcttgtc tgttcatgtg tacattcctc tcttacctat aatggtaccg ctatcacttt 2349781 atattttaca taatcgcgcg ctttttttca cgcccatttc taaaaatgta aaataaatgt 2349841 aagaattttc agccattaca gctttggcaa aaaaataagt aaaccaatga tacacgaaat 2349901 cacggcaaaa acgcaaacag ccccggcggc agcgtccttg gccgctttag caagagggtg 2349961 atgtttgtca gttattaaat caaccgtatg ttcaatggct gtatttaaaa gttcaagcga 2350021 aaacatacca cctatcaaaa ggaatataat catccactca ataatgctga gctctacaag 2350081 gaagccgcaa atgagaacag cgcaggcggc tgcggcatga aattggaaat tccgctccgt 2350141 ccgcgctgtt tcccatatgc cccggcctgc atgcacgaag cttttgaaga atcgattcag 2350201 ctcatttcta tgatcttttg agtccataag cgtccagcaa ttccttttgc ttagtaaaca 2350261 tctcctcttc ttcctctttc gtcatatggt catatcctaa aaggtgcaga aatccgtgta 2350321 cagctagaaa tccgagctct cttttaaaag aatgattata ctcctctgcc tgctctcttg 2350381 tgcgatcggc actgatgata atatcaccta aaaccggagg catttcggcg cccacgattt 2350441 cgatctcgcc ttctccctct tcttcaagag caaatgagat gacatctgtc ggagcatcct 2350501 ttccccggta ttctttgtta atctgatgta tgtcatcatt ggaaacaatc gtgacagaaa 2350561 cttcagcctg atcctgaacg ccttcacgct cagcggcaaa ttgaagcaga ttttctactt 2350621 ctttgagcat ctcttctgag acgcttcccg tttcatcaac gatatcaatc agtaaactca 2350681 tctatttcac cttcttagta gcctccggat attcaatccg ggagtggaaa attcctttta 2350741 atgttgcaca gagcgttttt gcgattgtat ccagctcttt aaatgtcaaa tcgcattcac 2350801 tgaactgtcc gtcctgaagc ttatcggata taataccccg gacaagcttt tcaattcgtt 2350861 caggatttgg attgtgcatg gatctgacgg ccgcttcaac actgtcggcc actgatataa 2350921 ttgcggcttc ctttgactgc ggcttcggtc ccggataacg gaactcttcc tctgtaatct 2350981 ggtcgccttt ttccttcgct ttatagtaaa aaaactttaa aagcgaggtt ccatgatgct 2351041 gctcagcaat atcgacaagc tctttcggaa atttatagct tctcagcata ttcgcaccgt 2351101 ctgtcgtatg cgagataata atatttttgc tcaactgagg tgacagcttg tcatgcggat 2351161 tgtcaatatt catttggttt tcaataaaat attgcgggcg ctttgttttt ccgagatcgt 2351221 gataatatgc gccgactctt gcaagcaaac cattagcccc aaccgcttca caggctgcct 2351281 ctgataaatt ggcaaccatt acactgtgat gatatgtacc tggtgtttcc gtcagtattt 2351341 tgcgcaatag cggatggtta ggattagaca gctcgagcag cctcatggtg gataaaatgc 2351401 caaagcccgt ctcaaaaaac ggcatcagac cgatgatcaa tacagatgaa gcaaaccccg 2351461 acacaacccc catgagcatt aacgtgccga tttcaagacc cgacagcgca gtgttctgga 2351521 tcaataataa ggatagaacg acaaccatat taataaacgc cacgaaaagt ccggtctgca 2351581 aaatctttga tcttgcattg tgttttccta aaaataatac acctgaaatg ccgctgatca 2351641 aataataaat ccctatgaca taattgaatg ttcctgtcac accctgatta aacatcatac 2351701 ttccgcaaat cgcaagaatg atacttccca aaatggcaat gcgttcattc atcagcagtt 2351761 tgattaagat ggcgccggcc gcaatgggga ccagatagcc gatattatta tactccatct 2351821 tctgaaacaa actgacaacc tccatgatca caagcaaaag tgttgtgatt atggagaata 2351881 acagaatgga ttggttttta aacttcagat tttgtttctg tttttcaaaa taatatacaa 2351941 gtgttgcaat gaaaagtccg atcataatca atagcccgct gatcggttta aagagatttg 2352001 agttatttaa taacccggtc agctcaagtt tcctgtacac ttcccgatca atgaggtcat 2352061 tttcttccac gagcacttgc ccctgtttga tttgaacctg ctggacatta tctgaggctt 2352121 cctgccgttt tgcctctgtt gctttcggat cgaagacgta attcggaata atagcaaaac 2352181 gcccgatttc tgtcgcggct cccaagtatt tagacggaat agaattgctc tttagctctt 2352241 tttctacctt atcctttgca tcagatagtt tatccgaagg gatttcactg ctcatgaccg 2352301 tatttaccgc ggtaatgacc gtatctctga caaaagaaaa gtcttcactg tctgctttca 2352361 gcaatgtctt gatggaatcc tccgatatag aatcattcac atctgatgtc aatttgtcct 2352421 ttacagattt gaccattgat ttttccgatg gtgatttact gccttcttcc gatgattttt 2352481 tcacttcact aatactgtcg aatattgatg acacaaggtc aatccgattg tctgtatatt 2352541 ctttttttaa tgtatattga tcttcaaccg cgtcctcagc ggcttgcttt ttttcctctg 2352601 tggctttttg atcttctacg gttgccggag cgtaaatggt cttgtcgctg actgaaaaca 2352661 ggtctaaatc aagtgtttcc ggcttaacat gtacaaagag caaagcaaac ataatggcag 2352721 ccagcagaag atacagcagt acatgcatgg agcgggcatt tttaaaactg ctccattttt 2352781 ttgagctgct tttggtctta gccttctttt tcaacacaag aacctcctct tgaaacatca 2352841 agcccataag caatcataaa aatgacccga taacgcgcga tcgggtcatt cagcattaat 2352901 tttgcttatc gtatgcttca ataattttcg caacaagcgg atgtctgacc acgtctgtct 2352961 ggtctagctc aatcatagaa atgccgtcta ttcctttcag catctccttc gctactgcaa 2353021 gtcccgattt gacgcctttc ggcagatcaa tttggctaac gtcacctgta atgatcattt 2353081 tagagccaaa acccagtctc gtcaaaaaca ttttcatttg agcaggcgtg gtattctgtg 2353141 cttcatcaag tataacataa gcatcatcga gcgtccgtcc cctcatatat gcgagcggag 2353201 caatttcaat gatgcctctt tccatcagac gttctgtatg atctgcccca agcacatcat 2353261 ggagagcgtc atacagcggg cgcaaataag gatctacttt ttcttttagg tcacctggga 2353321 gaaaaccaag gctttcaccg gcttccacgg caggtcttgt taaaatgatt tttttgatat 2353381 gtccgttttt taaagcatgg actgctttta cgacagccag gtacgttttc ccggttcccg 2353441 ccggaccaat gccgaataca aggtcattcc gcttcatagc ggccacgtat tcccgctgtc 2353501 ccattgtttt tacacggatt gatttgcctt ttgcgttttt tgtaatttct tcttcataca 2353561 tgctttcaaa gtattcaagt tcattcttct ttgccatttt gatggcgtaa atcacatcac 2353621 gttcagagat ctctatcccc ttgcgaatta aagcgaggag cgatcccagc agcctgtctg 2353681 caatctgaaa cgattcatca tcgcctgaaa cataaatcgt ctcgccgcgc gtaatgatat 2353741 ttaaattcag atctttctcc atcaatttca aaaaagaatc ttggttcccg aagagtgaaa 2353801 gcgcctcgtc cgggtttttc agtttttgat tcatcgcaag taaatgttct gtcattcttc 2353861 agtctccctg acaataggtg tggtttgaac gatatcttct ataacttggt agagaataat 2353921 caactttact ttaccattct caacagtctg gtgcaaaact ttttcacttt tcacctcgcc 2353981 gttttcgcct attttatcct ctacatcctg tttacccaat ttaatgcctt cttgaactgc 2354041 ttcttctttt gtatattttc gcaaagcctc ttcactttct ctcgtttgct ctttgacata 2354101 ggatacaggg agcttaaatc cgagaaaatg aagcgaatgc ttttcttgtt ctgtttttgg 2354161 atgcttcaat tcctcttttt taaacgtcat cccccagatc gggattgcca aagaaccaaa 2354221 agaaagcttg tgctttgtcc ttactttgcc cgtatagacg ttaaataatg tttcaagcgg 2354281 gactgtcact tctgatctat accaggtttc tccataaatt tctgcttttg aggcgacttc 2354341 ctgctgatgg tcttcgctgc cgatcagtcc cgaaacaagc agctgtccct tttcaacatg 2354401 atcgtgtatg gcggccatgg gctgtccttt ttgcacaaac attctcgtaa tggttgcttt 2354461 ctttttggcg acaatattgc gcgggctaac atatttttct ttttcgggct catttttctc 2354521 cacaactttc atatgaatgg tcgtcccctt cagatcaact ccgacccaag tgatattgtc 2354581 tattccattg gttaatgatt tctgtatttt ttcgggcgac atcattaaaa actgcagacg 2354641 gccctttttg acgccgattt cattaagatg ctgcctcatt tgatgttctg tttcaggctt 2354701 agcgcctgtc acatcaattt tccacaccat attggacagc aaaaacaaaa gaatgaaaaa 2354761 aatcgcaaaa ccgatcgtaa accctatatt cagctttgat ttcagcaaca ggaagggaaa 2354821 tcccttccga ttgataaatc gggctttaca tttaaattta cttcttaccc gccgaaaggc 2354881 atgtacatcc tgaagctgta tatataacga tacggcttct ttcttttttt tgacatgaaa 2354941 gaccggaatc ccctgtcttg tgcattcatt aaggagccgc tcaatccctc ttcccgtcaa 2355001 ttcaagctgg accttacccg aaaaaaaaga cagccattta tttttcacaa catttccccc 2355061 tcggctttat gactcaacat atcgaacgac atcaatcgta ccctccaaaa gtatctcttc 2355121 cggaagaatc gccttgatga caaaattttt accagatatg atgcactggc cctgcttcag 2355181 catcagccgc acttcattct cactgaaaag caaaaggcct ctgtggtttt ctatgtagat 2355241 atgaagtctg ccaaccattg taatcctcgg cagatccatc ataacgtccg ggggaatttc 2355301 caatgctctt gtcagccaag ctttcatacg attctttctt tgccccatac aaaaagaacc 2355361 ccctttcatc tcatatgtat gatttgaaag gaggttctaa cactttaatt tttacgggcc 2355421 gggcgcatcg tacggtgagg ttttttcgcc cgtggaggtc cgaacacctc tcctagaacg 2355481 atcccctgta cgacggtgtc tttattcacc tgaagcattt tttgttttgt gtatactgtt 2355541 ttttgtttgg cagcagcaag atctcgttcc agccctttca ggtttcttgc tgtttccctg 2355601 cgtctttctt ccgcttcccg tcttgcctgt tccatacggt tagggatagg tgcaggggca 2355661 tcttcttttg actgcttctt ttgaggagaa gcagattgca cgtgttgagg tttttttctt 2355721 ttttggctgt tttgcttttc ttctttgctc tttttgccga aaatcgcaga aatgattccg 2355781 atgatcgctg caataataag cggattggtc agtaaatctt ccatcagcgt tctcccttct 2355841 tagagagatt atgatttgcg gtcttcatcc gaagggtctt tcgtcagctt gccgaatgaa 2355901 tcacgcattt ctgtgtcagc atcgatgttc ttgatattca tgtaatccat gacgccaata 2355961 ttcccttcac gcaaagcttc tgccatcgca agcggcactt ccgcctcggc ttctactact 2356021 ttcgcgcgca tttcttctac gcgggcacgc atttcctgtt cttgagcgac agccatcgca 2356081 cgtcgttctt ccgcttttgc ctgcgcgatg tttttatcag cctcggcctg atcggtttgt 2356141 aaaattgccc cgatgttttt gccgatatct acatctgcaa tatcaattga gagaatttca 2356201 aacgcagttc ctgagtccaa tccttttcca aggactgtct gagaaatcat gtcagggttt 2356261 tcaagcactt ttttatgatt atcagatgaa ccgattgtag aaacgattcc ctcacctaca 2356321 cgagctacaa tggtttcttc ccctgctccc ccgacgaggc gctcgatatt cgctcttact 2356381 gtgattctcg ctttcgcttt cacttcaatc ccgtccattg cgacgccggc aatgaacggt 2356441 gtttcaatca ccttaggatt aacgctcatt tgaacagctt ccaacacgtc ccggcctgca 2356501 agatcaatgg cagcacagcg ctcgaatgtg agttcaatgt tagctcgctg agcggcgata 2356561 agcgcgttga cgactctgtc aacattacct ccagccagat agtggctttc aagctggttt 2356621 gttccaacat taagtcccgc tttatgcgct ttaatcagcg ggttaacaac ccgattcgga 2356681 atgacgcggc gaagcctcat cccaactaga gtgaaaatgc tgattttcac tccggctgcc 2356741 aaagctgaaa tccaaagcat tacaggcaca aatgtaaaaa atactgccaa aacaatgatc 2356801 gctactgcga caattgccag aatcataagt gttgacggat ccatataact tctcctcgtt 2356861 tctatttaaa tttctctcac gacaatgcgt gagccttcta cttttatcac ttttactttt 2356921 ttatcttttt ctgtaaacga tccctccgat acaacgtcaa ggcgttcatc atcaataatc 2356981 acggtaccgg aaggacgcag cggtgtaaag gttataccca cttttcccat taagtccgtg 2357041 cgcgtttgat ttgaaacgta gccgctctcc gtgtttgtag aatcatttaa tatcaatttc 2357101 ttaaagaatt tcatacgctt tcccaacacc cttgtcagta aaataaaagc tgtaatcgaa 2357161 acagctgagg cgatcaagag agaaaccgcc atgacagtga agctccccgc ggctaaaaac 2357221 aggctcgcaa taatcgctcc caagcccagt aatccaatga ttcctccggg aagaaaaatc 2357281 tcaagcagaa tgagaatcac ccctgctata aagaggagaa ccgtctcata cccggcaagg 2357341 ccggctgcaa gatgcccgta aaagaacagc aataacgcaa tgagtccagc cgttccaggg 2357401 aggccgacac ccggggaaaa aagctctacc gtcagaccta aaaaagcgat tgtcagcaga 2357461 atagggacaa tgaccggatt cgtcagccat cttgccgtct tttccgcaaa gctctccttt 2357521 gcatagctga tctgcgcctt ttcgaaccca agcttcttta cgagcgtgga caaattgtca 2357581 gcagtgcctt ctgaatagcc tacctcaatc gccttgtctg cgttaagtgt cagcagatct 2357641 cccttaggcg cgccaacttc cttggcatct atatctgggt cagccattgc gagcgcatat 2357701 tttggatcgc ggttattttt cactgcggca tcttccatct ctgccagcca aagtgattga 2357761 gctttttggt cagcggcatt gccttggcca tcaacaatcg cggcggctcc catttttccg 2357821 ccaggcgcca tataaatgtg atctgcttga agtgcaatat atgcaccagc agacaacgcg 2357881 cgtttgttga catatgcagt tacggggatc tcgctttcgg ttatcaaatc ggccatatca 2357941 atagcagatt tgaccaatcc ccccggggta ttgatatcaa gaataatatg gtctgcatgt 2358001 gcatcctttg cgtcttgtaa cgaacgggac aaaaacgagg cgagaccctg ttcgacattt 2358061 ttttcaaccg ggatcacata aacagtttgt ttttctgctt ttgcgttcag ctgtacgcct 2358121 aataaagaaa gtaaaaatat acccaaaaga gcagcacgga atcctttgat ttgaagcaag 2358181 ggcggtgtat ccctccttcc ttttataata agtgccttct cttcatacgt aacaaatgta 2358241 tcaaaggttt cattttttta tgtataaaaa aagacatctc tcttagaaag atgtcctttt 2358301 ctttgccatt taagacagtt gactgctcac aagcttatta attaaacttc cgtcagcttt 2358361 accttttact ttaggcataa ttgcccccat cactttgccc atgtccgctt ttgagctcgc 2358421 accgacctcc gcgatggttt catttacgat tgtacgcagc tcttcttctg acagctgctc 2358481 aggtaaataa acttctaaaa tgtccagctc tttttgaact ttatctacta aatctaaacg 2358541 attagcgttt gaaaattcct ggagggagtc tttacgttgc ttaagttcac gagaaaggac 2358601 agtgagttcc tcatcctcgg tcaaactgtc tttcttaagc ttaattgctt cattttgaag 2358661 tgaagcctta accattcgaa cgacagtcag tttgtctttc tcacggtttt tcatatacag 2358721 cttcatatcc tggttgagac gctcaagaag actcataaat ccaccctctt ttagaatttg 2358781 cgttttctag cagcttcaga ctttttcttg cgctttacgc taggtttttc ataaaattca 2358841 cgctttcttg cttcttgcaa agtacctgtc tttgatacac tgcgtttgaa gcgacgaaga 2358901 gcatcttcaa gcgattcgtt ttttctaacg accgtttttg acattctctt tccctccctc 2358961 cgaatacacc aatcgactac ctttaagtta cacatataaa catgtacttt gacattataa 2359021 tataagccat cagtcaggtc aactaagtga gttcactttt ccgtcatgag tgcgactgcc 2359081 tgtctatata atgaaagaaa ggggttggtg aataggatgt taattctgat tagctttact 2359141 gctcttatat tattctttct cgcaggcatg aacatgcttc gaaagggctt aatttcaatg 2359201 gcgtactcaa aaattgaaga acgtttgctt ttatttacag accatccgtt aaaagcgttt 2359261 cttatcagta ttgtatttac ggggatactt cagagcagct cagcctttat ggtcattgtc 2359321 atcggctttg taagtgcggg cgttctttct tttaagcgga cgatcccgat gattctgggg 2359381 acaaatgttg gctctacttt tacaactgaa tttattgcta tcaaaatgga tattgtgatt 2359441 tgggttcttt taataggagg tttattgttt tttctgactg gcaggtatcc tttgaaacag 2359501 ctgggaacaa gcttccttgg actgggcatc atcttctttt gcatcagcgg attcagccat 2359561 cttgccgggc cgctgacaaa gctgaaaacg ggcgccgacg ttctatacca tgttaacgat 2359621 tcaaactggt ccgctttgct catcggcatg gtgttaactg ccatcattca ctccagttct 2359681 gtctgtatcg gcattttgat gagttttatg aatgaaggga ttatcggact gacacaggcg 2359741 atgagcgtcg tactcggatc aaatatcggg acatgcatta cagctgtcat ggctgctgta 2359801 tccggcggat atgcggcgaa acagacagca tatgcccatg tggtatttaa cgtgctaggg 2359861 gtggctctag tattgccttt tctgaccgca gcgaccggct ttgtagagca gttatcacct 2359921 gatcccgcac aaaagatcgc gcatttcagc cttttattta atgtggtgac agctctttta 2359981 tttcttccgc ttacaaactt gttttaccga ttgattcacc ttcttatccc ggctaaataa 2360041 aaaaatcggt acattttaat gcaccgattt tttaggttaa gaagacaaac gcatgtgttc 2360101 agttatttca tcctcaacca cacggacaaa ctgtccttcg ttgtaaggat aacctgcttt 2360161 taggattttg acttttacga ttttgccgat catatcttcc gtacctttga aaacaacctt 2360221 catataattg tctgtgtaac cgacaaacat attttcttct tctgtttcct taaacgcttc 2360281 ctcagggata atctcaagca cttcattttc atactgagaa gcgtattctt ttgcaagctg 2360341 gtcagaaaga gcaatcaggc ggtgcacacg ttcgtttttc acgttttcat ccacttggtc 2360401 ttccattcgt gcagctggtg ttcctgtacg cttactgtaa gggaaaacat gcagctcaga 2360461 gaatttatgt tctttaataa agttataggt ttccataaat tcttcttctg tttctccagg 2360521 gaacccgacg atgacatcag aagtaacagc taagcctggc agtgcttttt tcaatttatt 2360581 taaacggtct gcaaagaatt ccattgtata tttgcgtctc atccgtttaa gcactgtgtt 2360641 tgatccggat tggataggaa tatgcaaatg attcactatc ttatctgagc ggtctaagac 2360701 ctcgatcact tcgtcagtga tttggctggc ttcgattgaa gaaattctga tccgtttcac 2360761 gccttccaca cgggtgtcta attcgctcaa aagcttcgcg aagttgtaat ctttcatatc 2360821 ttcgccgtag ccgcctgtat gaatacccgt aagaacaatt tccttatatc cggcatcgac 2360881 aagctgctgc gcttgtttaa tgacttcttc agggtcgcgg gagcggagca ggcctctcgc 2360941 ccacggaatg atacagaatg tgcagaaatt attgcagccc tcctgtattt tcaatgacgc 2361001 tcttgtgcgg tccgtgaaag caggcacatc aagctcttca tatactcttg ctttcatgat 2361061 gttgctgacg ccattaatcg gctggcgttc ttctcggtat tggtcaatgt agccaagcat 2361121 tttttcacgg tcctgtgttc cgactacaat gtcgacaccg gggatcgcca taatctcagc 2361181 aggtgaggtt tgcgcgtagc agcctgtgac acagatgaca ccgtcaggat tttgacgaat 2361241 ggcgcgtctg atcacttggc ggcttttttt atctcccgta tttgtaaccg tacatgtatt 2361301 aatgacatat acatcagctg tttgttcaaa gtctcttctt tcatagcccg cttctttgaa 2361361 aagctgccag attgcttctg tttcataatg gttgacttta cagccaagcg tatggaaagc 2361421 aacagttgcc attactgatc acctcttaat aactctgttt gataagaaat cgcactcaac 2361481 gcgtatagcg gagcggtttc tgtccttaaa attctcggtc caaggccgca cgtcacaccg 2361541 tcttgctctg tgagccgttc aacctccgct tctgttaaac cgccttcggg accaaatacg 2361601 atcaatagag atgatccttt cggaaggctg cttacaatcg cgctgaatgc gcttatttcc 2361661 ccttgcttcg atgactcctc gtatgcaacg acacatttat cgaaatcctg catcctttga 2361721 agaagctgct gaaaagaatg gacatccatc actcgcggca cttcgttacg gtacgattgc 2361781 tcagccgctt ccttcgcaat tttcgtccat ctttcccgct ttttctttgc ctttttgtca 2361841 tccagcttga caacagaacg cgcggcttgg aaaggaataa aggcatgagc tccgagctca 2361901 gtcccctttt ggataatcca ttcaagctta tctcctttcg gaaggccgct cgcaatatag 2361961 acctttatcg gaagctctct gttttcattc gtccattcta tcacaaggca ggacacttta 2362021 tctttggaaa cagattgaag ttcacatttt gcctcgaagc cgtcttgaga gcagcagata 2362081 atctgatctc cctcattcat tctcatcacg ttcacaatat gatgaacttc ttcgccggta 2362141 atcgaaaaag tcggcgcttc ctctatttgc tgcttcgtga gctcgataaa atatcgttgc 2362201 atacgctgtg acacctacta actgttattt tttcgcaata atgctgaccc aatcttccat 2362261 tgaaaggatt tctacaatgg taaagccagc ttgttccagt gcttctttta cttcttgttt 2362321 tttatgaccg atgattcctg acgtaataaa gtgaccgcct tcttttaaca ggctgtacgc 2362381 ttgtgaagta aagcgaagaa tgacttcagc caaaatgttg gccacaatca catcatgttc 2362441 cccttcaatc ccgtctaaca aattgttttg cttcacttga gcaatatcgc tgactttgtt 2362501 cagcttgaga ttgaggcgtg cactttctac agccacggga tcaagatcgt aggcatgaac 2362561 cgattcagcc tcaagcattg cagccgcaat acttaaaatt cccgaaccag tgccgacatc 2362621 aatcacctta tcaccctttt gcacaaagcg ttcaagcgcc tgaatgcaga gtacggttgt 2362681 cggatgtgtc cctgtgccga aagccattcc cgggtccatt tcaataatca gttcatcagt 2362741 atggaccggc gtatattcct cccacgtcgg cacaattgta aacttttcag aaattttcac 2362801 aggatgataa tactttttcc aggcagtcgc ccactcttct tcatttactt cagaaatagt 2362861 gatgtggttt ctgcccaaat caatattgta aagaaggaga ttattaatcg tttctttgat 2362921 gccgtctaca gtttcgccca gaaaactgtt aaccggcaga tatgctttga caatgacacc 2362981 ctcatctggg taatcattgg ggtcgagctg gtagatttcc ccgtacacat tctcacgttc 2363041 tttaattaaa tcaagcgggt cctctatcac aaccccactt gcaccagctt catgcaatat 2363101 atttgagata ggttcgaccg cttcatgtgt tgtgtgaatg cttaattcgg accatttcaa 2363161 aactaccaac tcctcatcca ataattaatc gcctttaaac gcgcgtttta ccttgtcaaa 2363221 gaaactcatt tcctgttcgt caggcaggtt tccgctgact tcggcaaatt cgcggataat 2363281 gtctttttgt ttatcagtca gatttgtcgg cgtaacgacg cggacgacga tatgctggtc 2363341 accctgtcca tagcctctga cattttgaac gcctttgcct cttaatctga atttcgttcc 2363401 tgtttgtgta ccggccggaa ttttcaattt cacttttcca tgcagcgtcg gcacttctac 2363461 ctcatctcca agagcagcct gagcaaacgt taacggcatt tcacagtaaa tatcatcgcc 2363521 gtcacgctcg aagaactcgt gtgcgcgtac atggaacacg acaaataaat ccccggcagg 2363581 gccgccgttt attcctggtt caccctgtcc cgagagacga agctgctgcc cgtcatctac 2363641 accggctgga attgtcacat tgattttctt gcgttttttg atttttcctt tgccgccgca 2363701 gtccgcacat ttgtttttaa tgattttgcc tgtaccttca cagtggtggc agacccgtct 2363761 gttaacgact tttccaaacg gtgtattttg ctccacgttt aactggccgg agcctccgca 2363821 gtgggagcat gtttctggat ttgttccagg tttcgcacct gagcctttac atgtttcgca 2363881 cgtttcctcg cggggaattt cgatggttgt ttctttaccg aaagccgcat cctcaaacga 2363941 cagggtcatc gtatactgta aatcagcacc ctggcgcgga gcgtttggat ctcttcgtct 2364001 tgtgcctccg ccgaatatac ttgagaaaat atcatcgaaa ccaaaaccgc cgaaatcgcc 2364061 gccgccaaaa cctccgccgc cgaagccttg gttagggtca gtgtgaccaa attgatcgta 2364121 atgcgcacgt ttttggtcat ctgacagcgt ttcgtatgct tcttttacct ctttaaattt 2364181 ttcatctgat ccggcttctt tgttaatatc aggatgatat ttttttgaca gcttccgata 2364241 agctttttta atttcatcct ttgaagcgct cttacttact cccagcactt catagtaatc 2364301 acgcttactc atctcgcttc actctcccga atttctcaca taaattagat tgtatcattt 2364361 tgaattatga tttttcaatt ccttttatcc cgggcaagaa aaaaagtcaa agccaagaga 2364421 tgcctgactt tgactttcta atcattgaat cagattatga aatgtgttct tttcggtcag 2364481 ctccggaagc ggggctgaca ctaaaaagaa cttatttttt gttttggtcg tcgtttactt 2364541 cttcgtattc agcgtcgaca acgttgtcat ccgctttgcc ttcagcgttt gctccgcctt 2364601 gagcttgctg tgctttagca gcttcttcat aaagcttcat agaaagctct tgaacgattg 2364661 tttgaagctc atcttttttc gctttgatct cttcaaattc gtttttctca atcgctgctt 2364721 ttaaagcgtc tttggcatcg ttggcttttt tcacttgttc ttcgtccact ttgccttcaa 2364781 gatcttttaa tgttttctca gtttggaaaa caagctgatc tgcttcgttg cggacttcga 2364841 tttcttcttt tttcttcgca tcagcgtcag cattttcttc cgcttctttt accatgcgtt 2364901 cgatctcttc atctgagaga cctgaagaag atttgattgt aatgttttgt tcttttcctg 2364961 tgcctaagtc ttttgctctt acgtttacga taccgttttt gtcaatatcg aaagaaactt 2365021 cgatttgagg cacgccgcgc ggtgctggcg ggatatcagt aagctggaag cggccgagtg 2365081 ttttgttgtc ggcagacatt gggcgctcac cttgaagaac atggatatca acagctgttt 2365141 ggttatcagc agcagttgag aacacttgag atttgcttgt tgggatcgtc gtgttgcggt 2365201 cgatcagttt tgtaaacaca ccgcccattg tttcgatacc gagagaaagc ggtgtaacgt 2365261 caagaagaac aacatctttt acgtcacctg tgataacgcc gccctgaatc gcagcaccaa 2365321 gcgctacaac ttcatccggg tttacgcctt tatgcgcttc ttttccagtt tcttttttga 2365381 ttgcttcttg tacggcaggg atacgagttg atccgccgac aaggatgact ttgtcgattt 2365441 cgcttgcaga aagtcctgca tcttgaagcg cttgacggac aggacccatt gtgcgctcta 2365501 ctaaatgaga agaaagctct tcgaatttag cgcgagttaa tgtaagttca aggtgaagcg 2365561 gtcctgcttc tccagctgtg ataaacggta aagaaatttg cgtagaagat acgccggaaa 2365621 gatctttttt cgctttttca gctgcgtctt tcaaacgctg aagcgccatt ttgtcttttg 2365681 acaaatcaat gccgttttct tttttgaatt cagacaccag atgatcgatg ataacttggt 2365741 caaaatcgtc cccacccaga cggttgtcgc cggcagttga acgaacttcg aatacaccgt 2365801 cgccaagctc aaggatggaa acgtcgaatg taccgccgcc aaggtcgtat actaggatcg 2365861 tttgatcttc atctgtttta tcaagtccgt atgcaagcgc tgctgcagtc ggctcgttga 2365921 tgatacgttc tacttcaaga cctgcaattt taccagcgtc ttttgttgct tgacgctcag 2365981 catcgttaaa gtatgcagga actgtgataa ctgcttttga tactgtttcg ccaagatagc 2366041 tttcagcgta tgatttaagg tgttgaagga tgatagcaga cacttcttgt ggagtgtaat 2366101 cctttccttc aatttcaact ttataatcag tacccatatg acgtttgata gacataattg 2366161 tgttagggtt tgtaatagat tggcgtttag ccacttcccc tacttgacgt tcgccgtttt 2366221 taaatgcaac aactgatggc gttgtgcggt ttccttcagc gttagcaata actttaggct 2366281 cgccgccttc aagcactgcc acacatgagt ttgttgttcc taagtcgatt ccgataactt 2366341 tactcacttg aataacctcc tgctatgtaa ttattgattc actttgacca tggaagggcg 2366401 aatgacgcga tccttcagct tatagccttt ttgcatttcc tcaacaacaa tgttggagcc 2366461 gtagttttcg tcttcagcct gcataacagc ttggtgcaga ttaggatcaa attcctgccc 2366521 tacagcttcg atggcttcga cgccttcttt tttcaaggct tctacgagct gacggtggac 2366581 catttccatt ccctggagca aacttttcgt ctgttcattg tcggcttcaa cctgaagcgc 2366641 tcgttcaaaa ctgtcaagag ccggcagcaa atcagtcacg atattttgag aacggtattt 2366701 ttgggacgct tccatctcta aacggctgcg tcgtttatag ttttcaaagt ctgcttgaac 2366761 acgcaaaagt ttgttttctt tttcctcaag caaaccttgc aattcgttaa tttggttttg 2366821 aagaagttcg ctttcatttg tttcttcctg ctgttcatca gcggcagctt gttcttcaat 2366881 gatttcttgc tcttctgttt cgttttgttc aacggtttgt ttttcttctg acattgtgtt 2366941 cacctccctc aaagtgtaag gagaaggaca ggtgctgccc ttcgataaaa tttgccaaaa 2367001 ttcccttatt catcatacag acttgttaat gcttttgaca agtccgaagt cacatgctga 2367061 agcaggctga caaccctgga ataattcatg cgggtcgggc cgataatcgc aattgagccg 2367121 atctgcttct ggtctacgga ataagaagcc gtaatcagac tgcaattttc catctcttca 2367181 tagtcgtttt cttttccgat tttaatcgaa attcccgtgt gcggggattg aaccagcttt 2367241 aaaacatcct gttctttctc aattaatgaa agcagcgacc gaactcgggt gatatcatgg 2367301 aactcaggct ggttcagcat attgattttc ccgccaaaaa acaacttttc aacgtgattt 2367361 gtggaatgaa aggttgaacg aagcgcgtcg agtatattgt catagttttt aatgtgctgt 2367421 cttaggtaca tgacaacttc tttaaatatg cgctcattca gttcatccat tggaacgccg 2367481 cttaaacggt cgttcagtat atttaccagt ttttcaatat cagacagatc cattttggtc 2367541 ggaaagttaa tcgttttgtt ttccacatgc cccgtattgg taacgagaat cgctaccgcc 2367601 atatcaggct gaatcggaat gatttgaatc tgtttaaggt aattctcact caacttcggc 2367661 ccgagtacga tggatgtgta attcgtcaga tcggacaaaa tttgcgctga tttttgaact 2367721 gtcttctcca gctcgaaaat tttctctttg aagatcgagt ggatttggtc caggtcgctt 2367781 ttcgtcaatt tgacgggtga cagcaaatgg tcaacatagt accgataccc tttttctgac 2367841 ggaacacgtc ctgaggatga atgggttttt tcaataaagc ccaattcctc caagtcagcc 2367901 atctcgtttc ttattgttgc agagctaaat gtgatttcat cttttttcga aagagttctt 2367961 gatcccaccg gctgtgccga tttaataaaa tcgttgatta taacctgaag gatcagcagc 2368021 tgacgatttg ttaacatcat catcacctct gttagcactc tcaataagcg agtgctaatt 2368081 ctataacaaa agtatcaaac cacaagaaaa atgtcaatta taactcaccc aaaaaagcgc 2368141 caaaaacttc attgcctaat aatttccctt gatgagtcaa ataaacggca gactccgaat 2368201 tgtgaatcag ccctttttca gcgaggtctt ttaacacgct tgggaaaagt ccatccaggg 2368261 aacggccgta tttttctgcg aatcgttttt tgctgacacc ggctgttttt ctcaaaccta 2368321 aaaacatttc ttcctcaatc tgttcttctg ttgtcacttc atgtgtatct ctgtacggaa 2368381 aacccttttc agctatcagg tcaatgtaat gcttaacagg tccgacgttc actgttcgtg 2368441 tgccgccaat atatccgtga gcgccagctc cgaaaccgaa atattgttcg ttgctccaat 2368501 acgttagatt gtgcttagat tccatgcctg ccttagcaaa gttgctgatt tcatattgat 2368561 gaatgccgtg agcttccatc ttgctcatca ctatttcata catttcagct tcctgctcct 2368621 gcggcggaag atgaagccgc cctttttgca tcaaattata aaataccgtt ttcggttcta 2368681 caataaggga gtaaacggaa taatgctcag cgtccaatga taaagcagtg tttatggaat 2368741 gttccagatg cttgagggtt tgccccggaa gcccgaacat gagatcaaga ctgatattct 2368801 caaaaccgat ttcccgcgct ctttcaaaag aggtgaatac atctttttgc ttgtgcactc 2368861 ggccgatttt ttctaacaga tcgtcttcga acgtttgcac accaaagcta aggcgattta 2368921 cgcctgcttc ttttaatatt tttaatttct ctgcggacaa atcgtccgga ttcgcttcaa 2368981 ccgcaaattc cgataagtcg cttgagggct ttagcacgcg gttgatcata tccatcagct 2369041 ttttaagctg ttcctcagac agggaggtcg gcgtgcctcc tccgataaag attgttttga 2369101 gatcaggctg cccggttttt gctattgtat ttatcatttc ctgttcgagt gcgtttaaat 2369161 actcgtcgac tggctgactt tgaataaaat atttattgaa atcgcagtag tggcaaatat 2369221 gctcacaaaa tgggatatgg atataagctg atttcaacgg attcaccttc tttacagaaa 2369281 gaagccgcag tacaagactg cggcggcttc tattgttttt tcggactgtc gtccattttc 2369341 agaactgcca taaatgcttc ttgcggcact tcaactgagc cgacctgctt catacggcgc 2369401 tttccttctt tttgtttttc aagaagtttc cgtttacgcg agatgtcccc tccgtaacat 2369461 ttagccaata cgtttttacg cattgctttt atggtggagc gggccacgat tttctggccg 2369521 attgcggctt gtaccggaac ttcaaactgc tggcgcggaa tgagttcttt cagtttttca 2369581 acgatcactt ttccccgttc atatgcgtaa tcacgatgca cgataaagga aagggcatcg 2369641 attttttcac cattcagcat aatgtccatt ttcacaagct tggacggttt gtagccgatc 2369701 agttcataat caaaggacgc atagccttta gtgcttgatt tcagctgatc aaaaaactca 2369761 tatacgattt ccgctaatgg catatcataa atgatgctga cacggtttgc gtctaaatac 2369821 tgcatatcaa tgaaattgcc gcgttttcct tggcaaagct ccattacagc gccgacatag 2369881 tcattcggca ccatcatcgt cgcttttacg tatggctcct caaccctttc gatcttttga 2369941 ggatccggca tgttggacgg gttgtcgaca acgacctttt cgccgtctgt catatacacg 2370001 tcatagataa cgcttggcgc tgtcgtaatc aggtcgatgt tgaactcacg ctcaattcgc 2370061 tcctgaatga tctccatgtg aagcatgcct aaaaatccgc agcggaaccc gaatccaagc 2370121 gcttgcgaag tttccgcttc atattgaagg gaggaatcat tcagctcaag cttttcaaga 2370181 gcttccctta aatcattata cttcgctgta tcaatcggat acaaaccaca gtacaccatc 2370241 gggtttagct tgcggtatcc cggcagcgct tcttctgcag gattggcagc gctcgttatt 2370301 gtatcaccga cacgtgtgtc accaacattt ttgattgagg cagtcaggaa gcctacatca 2370361 ccgaccgtca gttcatttgt cggagttgct ttcggcgtga acacgcccac ctctgttact 2370421 tcgaattctt tgccggttgc catcattttg attttttgtc ccggctttac cgttccttca 2370481 acgactctga tataagccac gacaccgcgg taggcgtcat aaagcgagtc gaagatcagc 2370541 gctttgagcg gcgcctccgg atctccggtc ggagctggca ccttttctac gatttgttct 2370601 aaaatctcct caatcccgat accggctttt gctgaagcaa gcacggcttc tgatgcgtca 2370661 aggccgataa cgtcttctac ctcttggcgc acacgttcgg gctcggcgct cggaaggtcg 2370721 attttattga tgaccggaag gatttcaaga tcgttgtcaa gcgctaagta gacattggcg 2370781 agcgtctgcg cttcaatccc ctgggctgca tccacgacaa gaatcgctcc ctcgcaggca 2370841 gcaaggcttc gggatacttc atacgtgaag tcgacgtgtc ccggcgtatc gattagatga 2370901 aagatatatt cttctccgtc ttttgcttta tatttaagct gaacagagtt taatttaatg 2370961 gttatgcccc gctcacgttc aagatccata gaatcgagca attgttcttt catttctcgt 2371021 tgagtgattg ccgacgtttt ttctaaaata cgatccgcta aggtcgattt tccgtggtca 2371081 atatgggcaa tgatagagaa attccgtatt ctcgattgcc tctctaaacg cttttcttta 2371141 tctgtcacaa tctatcactc ctactattaa acgcaaaata cactagctta gattatatca 2371201 ataggattgt aaagattcaa tgtaaaacaa gaaagagaaa agttccctat catatctggg 2371261 ttgcttttct ctttcacgta cttattgatt catatcccgt atccattcat acattgactg 2371321 ggcagtattg gttacggtgt ccgaaagcgc ttttccggct tttgaaaaca tattgaatgt 2371381 ctccaccttt tccagctctt tttgtttttc tactaaatct tttgccgtga ctgtttctcc 2371441 taggattgag gcttcttttt cattatcttt tccgtcggtg agcgtaaacg cccccttcag 2371501 tgaagggtca tgatagcctt tcatactcag catcccgtgg tttgcctgct gcatgccgaa 2371561 cagaacgcct aaaaacatga tcgtgacaag cagtaagcac tttccaaagt atgcaatcaa 2371621 atcaaccacc tatttcttat tgttttttcg tctccccgct cgctgcgttg accttttcag 2371681 catcccagta catttcgctg aatacgtccg cggccgcgtt agccgcacgc tgcagctctt 2371741 cgagattatt atccactccg ccaaactcga gcaaaagcgc tctatcggtt aaatcctgat 2371801 tgtaaacacc attatcgcct ggcgagcctt tggaaaagac acctgtgcta agtccggggt 2371861 attttttctc catcagttta tgaagctcac tcgcaatttt atagttttct tcgaagtttt 2371921 tgcttttttt cccgacgaca aaggctaccc tggcatagct tttcccttta atcgttgcgg 2371981 ttgtgtcttt tttgcgccga gagtctctgt ggatgtcaat gatatattgc agatttttgt 2372041 ttgaagcgag ggcgtctttc acgaccggcc ttgattcatc ataggacctg gcatagttta 2372101 agcctttttt attcaatttt gactgtatat cggttttatt cactgtggct ccgattccct 2372161 gggattcaag cgcttgtccg aacatatctc ctacaagcgt gacattggct ttagaatggc 2372221 gcgccatgtc aggatcggtc tcgcctttta atagagggag atatgattcc gtattgtgcg 2372281 tgtgatagat aaacacgacc tttttatcac ctgttgtttg tttcggcgga tctttttgcg 2372341 cattatctga ttgcgtttgc tgtttttcaa tctctgccaa attcgcttct ctttcttcct 2372401 ccatcacctt agacggcggc ggcgattccg caggcatatt cgtataatcc gttccttgtc 2372461 cagctaacaa aatctcggta tcaaattgtg caaatcctgg cagctcccga ccgagaaagc 2372521 tccgcggatc ttcgaggtta atgctcgtcg ccagctttaa agaaagacga gaaagatgaa 2372581 atgagctgtc tgtttgagag aggtcagaag cgaaataatg gttttccatc tgcagcaaat 2372641 gtgcaaatac gtcacccggc aattcttcag caatcccata aaaagagtca gacgacggcc 2372701 taagttccgg ccggagagac gtcagcacac cggatagaac aaaaatcacg ataaggctta 2372761 cgataaatag aaagatggct tttaccgctt tccctccatt taccgcaaca acaatctgtc 2372821 tgtttctgcg tttatttctc attgaatccc tccagcgctt gtctagtaat tactctatga 2372881 acaagctaga ggaagtagaa ctgtttagtg attgtaggag cctttgtttt cttgtgacac 2372941 tttttcatga agcgctgtgt ttaatccgtt cgctaaaaca tttgccatat cgtcgataaa 2373001 tgaatcgact tccttcggtg taaccattaa gttgtgccct aaaggcgaaa gcacctcgtg 2373061 aatgagctgc cgtttttcat cttcttgaag ggttccgaca atacctagga acgattggcg 2373121 ctgcttttga tcgggaagat cgtcttcagt gagcactttc tttttcccaa acgtcatgcc 2373181 tgccggaaca agcgatcttg atggcctgtt atccttcatt tctctgccaa aatgttttaa 2373241 tatgtagtcc accgtgtcgc tggcaattgt cacggcatca actactgtcg gaacaccgat 2373301 agcaatcacc ggaacaccaa gcgtgtcttt gcttaaatct tttcgtttat tccccactcc 2373361 agaccccggg tgaatgcctg tatccgatat ttgaatggtt gtgttgaccc tttccaccgc 2373421 ccgcgccgcc aacgcatcaa tggcgatgac aaaatcaggc ttcgattgct caatcacacc 2373481 tttaataatg tcacttgttt cgattcctgt tatccccatt acacccggtg caaaagcact 2373541 gacaggcctg taaccctcct gtacgttttc cggctgaagc ttaaacaagt gccttgttac 2373601 caacagattt tctactgcca tcggtccaag cgcatcaggt gtcacgttcc agttgccgag 2373661 cccaacgatc aaacagctcg catcttttga gatattaagg ttttcaagaa aagctgagaa 2373721 ttcctccgca aagacagcag agaccttctc ctgcatttcc gaatcattct ccctgattcc 2373781 ctgtgcttca agcgttaaat agcgcccttc tttttttccc gaaagctctg cgccttcctt 2373841 tgtaacatca actgtgcgga ttttaatgcc gccgtgatca cgctcttttt caataaagcc 2373901 tttaatttct tttgtcggca cagcctgctg attggccatt gcttccttcg tttccactgc 2373961 caaatcggtc cgtatcaaat actgattcac atccagctca ctctttttca tacaggggcc 2374021 tccttcacat taagtaccta tattgttgcc atttgctgaa taaatcatgc taaaaagaga 2374081 accttcaatg aaaaatactt tacatttata ttgcaatcta aaggtgtgtt tgatagaata 2374141 caatttgttc tattgtgaag aagatttaac cttaagacac tgtgctacag gttgtatctt 2374201 aggaggtgaa acacatgcca aacattaaat cagcgattaa acgtacaaaa acaaacaacg 2374261 aacgccgcgt tcataacgcg acaatcaaat ctgctatgcg tactgcaatc aaacaagttg 2374321 aagcttctgt tgccaacaac gaagctgaca aagcgaaaac tgctcttact gaagcagcta 2374381 aacgtattga taaagcagtg aaaacaggtc ttgtacacaa aaataccgca gctcgataca 2374441 aatcaagact agcgaaaaaa gtgaacggac tttctgcata atataaaaac gatcctcaat 2374501 aatggggatc gtttttttca tttcttttta acagctgtaa aaggaacagt tcgagcagga 2374561 gctgcttgtc ctttttcccg gttttcatct catagtccat gacggcaagc tgttcaataa 2374621 ttaaacggag ctcctcctct gaaaaaagcc ttgcttgatc catcgccagc tttacccgaa 2374681 atgggtgaac ttttagatta gaagcgattt gtttttgtcc gtatccctgt tccgcgaagt 2374741 acttcgtctg cagaatcagc cggaactgat tcgaaataag cgccataatt ttgatcggtt 2374801 cttcattttg ttttagcaaa tcataaaaaa tttgcagact ctctgttcgt tttcggttga 2374861 cgattttatt gatcagctca aaaatatttt gttcaaggct tctagcaaca agcattttta 2374921 catcatccag cgtaatttct tcacgatctc caataaacgt gcagagcttt tgaatctcct 2374981 gaaaaatcga tgacagatga ccgttcacaa gcagaaccaa atgctccgcc gcttccgtgc 2375041 cgattgtttt ctgctctgtt tttgcaaggt tgacagtaaa gtctgtcgtt tcctttgcat 2375101 ttaattcctt cgcctccatc ataaacgcgt gcttctttaa cgctttcgtc agcttttttc 2375161 gctcatcaag cttttcatac ggagcaagca ggacaaagac tgtgtaaggc gcaggtgatt 2375221 gtatatatga ttcaagcgca ctgacgttgt gctcaatttt ttcttttttc ttttcacctg 2375281 ttaaaaaata tggatttttc acaatgacaa gacgccgctc ccccataaac ggaaacgttt 2375341 cagcatctgc aatcgcttga tccagcgggt cctcttccag atcaaaaacg gacagattga 2375401 aatcctttgt ctcctgatca acgaccgtct gtctgatcct gctgacggtt tcttgcagca 2375461 gatatgtctc ttttccgtat aaacaataaa ccggatggac ctctcctttt ttcaggcttt 2375521 tccacacatc aaataccatt gttgtacgac ttcctctctt tcatcatccc cttctatcct 2375581 aaattgagtt tgcaaaatag taaagaggaa gcctgactgc tgcttcccca tttatattaa 2375641 acgcctgttc gcaagccccc gggacagctt gtaaaaaggc gataatcacc agaacagaaa 2375701 acgttacctt agcttctaga tttttcaaaa caattccatt atacttaagt cagtcaggag 2375761 ggataaagtt gaatgatttt gaaaaaaacg ttcaaagcaa acgaaatgat gctgtagatt 2375821 cagctgttgg ttttgttgtg tccttcggat ttttcgcctt cttgtttgtc atggcaacgg 2375881 ttattcacct agttggttca taacagcgac tgcccgggct gctgatttct cggcagtctt 2375941 ttttagttcg tctctgttat atctgatgta tcatatggag gatagacaga aaaggttcca 2376001 actctgtttt tgtatctata ttggatcgtt ccgttttgat ctgttcgcag cacgcggata 2376061 gaatgtctct gtaatagttg cagaactttt tgatgaggat gatggtaccg attgtttttc 2376121 ccggctgaga taatggccgt tttcggctga agctgttgga tgaattcttc accggtagag 2376181 cctttgctcc catggtgccc cacctttaac acatctgctt ttatattcgg aaacacgttc 2376241 atcacctctt gttccccttc tttctccaga tcacccgtca agatccagct cataccgccc 2376301 gtctccatcc acagaacgag agatgaatta tttttgcttg ccggatcagg tgcttccggt 2376361 gacagtacat ggaactgcaa atcctttatt tgcaacacat cgcctcgctt cacctcttca 2376421 attgccactc cctcttccct ggctgcctgc agcactttct catctttagg ttcagaaacg 2376481 aaccctttcg gaatcacgag gcgctttact ttatgatgct tcagcagaat ctccgcctct 2376541 ccgatatgat cttggtcagc gtgcgtcaga attaaagcgt caagctgctt gattccctta 2376601 gcagttaaaa acggaatcag caccttttcc cccagtgaaa acggatgctg tttttcgcgc 2376661 caaggctctg acgagtaaga caaagtgccg ccggtatcaa ttaagacacg accccgctga 2376721 tgcggagcac ctacaaacat gctgtcaccc tgtccaatat ctatcatatc cacttctcct 2376781 tcggaactaa gacacggata tataaagagc agaaacatca ccgtgcagca aatgcctccg 2376841 gttaccatca actgcgacaa ggagcgtttt tcaatcgcca taagcaatag gatgatcgtg 2376901 actgtgaata aaaaaagcaa aacaggtgca ggatgtgcga tcataatcgt gaacacatca 2376961 acatctgcaa tgtttgtgat taacctattg atccagctta tcaataaatc aaaccagctg 2377021 aaaaacaatc tcccaaacga agcggaaaga cttaatagaa gaacacctgc tacagctccc 2377081 ggcaaaatac agaaggtata aaatggtacc atcaacatat tcatcggtac gctgatgata 2377141 gaaaactgat gaaaatgata taggagaatc ggaagcgagc ccagctgagc gatgagtgat 2377201 acaattgtca gctgccccaa ggaggtttta acctgctgaa aaatagaaga ggatagaatt 2377261 aaagaaaaac tgacggcgaa cgatagctga aaaccggctt caaagagatg ataaggattg 2377321 aagagcagaa ggacgatgta cgaaaggcaa attgcagttg cagagcggac acgccatttg 2377381 acaagacttc cagctaagta aacacccgac atgagagcgg cgcgtagcac tgaaggagca 2377441 gcgccggtca acatcacata gagcggcaga aataacagca acagaattga cgccttttct 2377501 ctagttatac caaggcggat catgatataa aacaaacctg ctgtcaaaat ccccacgtgg 2377561 agtcctgata ttgccaagag atggacaaca ccaagctttt gatacgcggt aagcacttca 2377621 tcctccacgt aaaatctgtc accaactgta agtgcctgta caatccctgt cgaatcagga 2377681 ggcagaaggc tgtttgtgaa tgatatgata tgttttctca agctgagcac cttgtacttg 2377741 aaattttcag gttcgctgca gttttggata gacgtgacag agtagttcca atgaatatgc 2377801 tgccgataaa gatactcgtt ataatcaaat gcacccggca cagttgcgtg attcggttct 2377861 tccaatgtac cagtcaactc acatgacatt cctggttcta tgtataacag ctgttctttt 2377921 tcaccagcag actgaatgcg atacgcagca gcccattttt ccttatcagg tgtctcaacc 2377981 atcatagaca tacggtcgcc gtcaattttg ggaatagtgt caatcactgc cttgaattga 2378041 taggttccct gccgatagga agagacattc tgagaatctg tgactgcata cagtacaaaa 2378101 aacaatataa aagagaagaa acaaacaata ataagaaaag cgtgcctcgt tttgattaaa 2378161 atgatgagga gaaagaggat gaaaagaaaa atagcgggga aataagcggc ggcagtaatt 2378221 ccagccgttg ccgaagctgc cgccataggc aataataagc gcgaattacg cattcatcac 2378281 acgtagctcg tgaaaagtgt attcgcctgt tcatgtatct ttttcaattc ttcctccgct 2378341 aaaccggcat cagccaattt ccctattaga cccgctacaa atgaaagctt ttctctgttt 2378401 ttcagatcaa cgatcatttc atcgagttca acctgttcaa cagttacacc cgcctgttca 2378461 aataattcct gcgcatacgg atgtgttttg taatcctcag cataataaac cgttttgata 2378521 ccagcttgaa taatagattt gcagcattga atgcacggat aatgcgtcac ataaatctcg 2378581 gctccatcag tcggcacccc aaacttagag cattgaagaa tcgcattcat ttcagcgtga 2378641 atggttcttg cgcaatgatc atctatcatt aagcatcctt catctgcaca atgtacgccg 2378701 cccgcgattg acccattgta gcctcctgct atcatgcgtt tgtctctgac tatagtagcg 2378761 ccgacagata atctcggaca tgtgctgcgc agcgccaata aatggctttg agccataaag 2378821 tattgattcc atgaaattcg ttccacgttg ttccctccaa atgttgtgtt gcctgacctt 2378881 tagtttacct atcataatgc atgaccgtca aatcacttta ctgtaatgga agactttatt 2378941 ttctcaaatg acttttcacc tattcctgaa accttagtga tatcttcaat tgtttggaaa 2379001 cgaccgtttt cctcccggta tgcaataata gcttcagctt tggatggccc cacccctgag 2379061 atgccttgta actcctctaa ggttgctgta ttgatattca ccagcgctcc cttccctcca 2379121 tcgctttgga cagaccctcc gccaccttgc tgcactgctg tttcctctcc ctttttcggg 2379181 atgtacacca ctgtcccgtc ctgcagaatc tccgccaaat ttacttgcgc ttcgtctgct 2379241 tgttcactgg tcccgcccgc tttctcaatt gcctgagata ctctgtcccc tgttcgcatt 2379301 tcataaacgc caggatgctg aacagcacct ttgatgtcta tcacaattgt ttcgtttgac 2379361 tcgtcgttgt ttgcttcctg ctttaccact gtattttctg tctctgttgg tacagcttgc 2379421 ttcaccggct ctttattttt ccctgtggcc agaaagatca taatcgctgt gaaaacagcc 2379481 gcagaagccg ctaaaataat tgctttctta tgctgattca accaattcat cgtgcatgtt 2379541 ccccgctttc gtcatatttt attttcataa cacatatggt ttagaggata atagctcaaa 2379601 ggaggggaaa ccattgaaga taggctttat cggcacagga aatatgggta cgatccttat 2379661 cgaatcattt attgaatcaa aagcggccga tccctcaaac atgacaatca caaaccgcac 2379721 aattgaaaaa gcgttgcaca taaaaaaccg ctacaacagc ataaacgtta ccgaaagtct 2379781 cgaaaagctc gtttctgaaa acgagatgat ttttatttgt gttaagccgc ttgatatata 2379841 tcctttactg gcaagagcgt taccttattt aagaaaagat catattctca tttcaattac 2379901 aagccccgtt caaaccgaac agctcgaaca atatgtgccg tgtcaagtgg cgcgagtgat 2379961 cccaagtatt acgaacagag cgctggcagg tgtttctctc gtcactttcg gcacaagctg 2380021 cggcgaatct gcaaaagcga aaatcaatga gctgatgcag catatctctc atccgctgca 2380081 aattgaaagt gacatcacga gggttgcatc agacatcgta agctgcggcc ccgcttttat 2380141 gagctatctg attcagcggt ttatagatgc agctgtttcg gaaacatcag tgtctaaaca 2380201 ggacgcgatt ttgatgtgta aggaaatgct tgtcggaatg ggaaaactgt tagaaaccga 2380261 attgtatacc ctgcctgcat tacaggaaaa ggtttgcgtt aaaggcggtg taacaggaga 2380321 aggcattaaa gcgctggaaa gcggtgtgca ggatatgttt caccgggtat ttcaaaatac 2380381 tcatatgaag tacgaggagg atatttccgc agtgaaaaag cagtttcatg tgtagacgag 2380441 tatgtcatac gttcgtctgt actgcaaaag cataaaaaag cattttaaaa aaccatcgtt 2380501 ttaggaaacg atggtttttg atttctgcgc cttgaaaaag aggcgttctg attgtgctga 2380561 tggctcggta tccgtaaaat cagctgtcac gcgatggagc tgaaagccgc agttcttaag 2380621 catttcttcg tattcttcca ccgggaacgt tctttgctcg tgtgtctcat caaaacgatc 2380681 atacgcttct ccgttccaca caaaaaacga catatcatga atgacagaaa gctcgtcact 2380741 tccggcaaag ctctgccaaa tatagctgat atcttcgtcc tggtcagcaa atgtgctatc 2380801 cggaaagact tccgcaattt taaaagatga atgaacatca aacagcagga tgccttcagg 2380861 ctttaatacc cgaaaaacac ttttaaaggt ttcgatcaca tcattttttg tttttaaata 2380921 atttaatgag tcacagcata tcacaacagc gtcaaattga ccgtcaaagc cggtaatctc 2380981 tctcatatcc tgctgaagaa ataaaatagg ctggctactc gatacctttt gctgggcgaa 2381041 agaaagcatc tcttcgctga gatcgatgcc tgtaacctcg aagccttttt cggcaagccg 2381101 gatggagatt tcccccgtgc cgcatgccag atcgagaata cggccttttt ccgggagaga 2381161 tgcttcaatc cattttgtcc attgatcgta aggcgcgtgt gacattagct cgtcatacac 2381221 gcttgcaaag ccttgataaa tcattgattc attccaaagt caagatctgc gagcggagcg 2381281 tctccccaca gcttttcaag gttgtagtag cttctttcat ccttgtggaa gacatggaca 2381341 actacatcgc ctagatcaac gagaacccat cttgcttcat caaagccttc catctttttg 2381401 acttgaatgc cgttttcatc agcttgatcc ttgatttcac gggcaatcgc ctgtacctgt 2381461 ttatctgaat ttccgtggca gatcagaaaa taatcagcaa ccagagaaat accttccata 2381521 tccagtgcta aaatatcctc tgcccgttta tcatcgcaag ccgcagctgc gatctttaaa 2381581 atggactttt ggttcattca caaattcctc ctgttcagct gccagacaca agccagttat 2381641 acgttaaaaa tgtgtctgga aaaaccggtt gatttttttt cataagaaaa accattgtat 2381701 ttttaatgga ctgaatcagc gcttgattca aatctgtctc agcaagctta cgcacctcat 2381761 cgacaccggg aaatgcccgg tttggctcaa tgtaatcggc aacgtaaatg actttttcta 2381821 aaagtgtcat gccggggcgg cctgaggtat gatacctaat ggcgtcaaga atgtcttcat 2381881 cttgaacccc tgcctctctt tggaccaaat aagcgccgac cggagcgtgc cagagctccg 2381941 gattatgatc caataaatgc gcaggcattt tttcacgcgc aataatttgt ttcatttctt 2382001 ctttcgggcg gaatttggcg taatcatgaa agattgccgc tatttccgct tttttagaat 2382061 cggctccaaa acgctccgca agttcgatcg ccgtgttcat cacgccaacc gtatggatat 2382121 atcggtgttc ggtcaattgc tgcttcacgc atgcaagtgc ctcctcacga ttcatataaa 2382181 ccattctcct ctacatactt cttcacttta tcagggatta agtagtcagt gggcttcttg 2382241 cttttaaacc gttcccttat catagttgat gatacctcaa attccggaac gtctgcaaag 2382301 agaagcggat aaggggtttc aacatgaaaa ccggggcgct ttactccaat aaattgaatg 2382361 aggttcagca gctcgtccag cttataccat ttcggcaaat attcaatcat atcagcgccg 2382421 ataataaaga acagctgatc atttggataa cgctgcttca gtaaagaaac ggtatcaaag 2382481 gtatatgatg gcccttctct ttccatttca acaagctcca gcttaaagga cggattagat 2382541 tgaattgcaa gctttagcat ttccacgcga tgaaagctgt cggtatagtc ttcgttctgt 2382601 ttatgcggcg gaatttgatt aggcataaac caaatttcat caagccccgc ctggtacagc 2382661 acctcattcg ccattaagag gtgaccatta tgcggagggt caaacgtgcc tccgaaaatt 2382721 ccgattttct tcatttcaac cacctttaag gaagctcgat ttgtttattt tcctttgatt 2382781 ccttatataa cacaatcgta ttgccgattg tctgcaccaa ttgagagcgg cttcctttta 2382841 caagagcttc cgctacatcg tttttatcct cttcgcaatt ctgaagcacg ctgactttaa 2382901 tcagctctct cgcttcaagc gcctcagcaa tttgtttaat catgttgtcg tttactccgc 2382961 ctttacctac ttgaaaaatc ggcgttaaat gatgcgcttt tgaacgcaaa aaacgttttt 2383021 gtttacctgt taacattctg ttcctcctaa ttttcctatt acaatagatc tcattttttc 2383081 aatattaggc tcttgtccag tccacaattg gaaagacaat gctgcctgtt caacaaacat 2383141 gcccacacca tcgagtgttt tcaagccttt ttggcttgct tcttttaaaa gtgccgtctg 2383201 tattggatta tacacgatat cacatacgac ggcactgctc gcggcacgct gtaatgaaag 2383261 cggcacatcg tccacgttcg gatacatgcc cacagacgtt gtatggatga taacatcata 2383321 ctgctcaaga cgttcttctg cttcttttat gcttaatact tctttattgt gaaacgaggg 2383381 agtagcttct gtaagccgct ttgctttttc taacgtccgg ttgcaaatgt caaatttttt 2383441 cggggtattt cggacaattg ttgtaaaaat ggctctcgcc gctccgccag cgccgatcat 2383501 taagaatgac agttcagaga tgggcttgtc taataccttc attaatgact tcacgaagcc 2383561 ttccccatcg gtattgtatc cgacaagctt atctccctct cttctgaccg tgtttacggc 2383621 accgagcact tttgcactct catcaatatg atccaaataa tccataatgg aaaccttgtg 2383681 cggaacagtc acattgattc cttgtacgcc tagagctctt attcctttta ccgcatcctc 2383741 cagatcattc tcttctacct tgaaggcatg ataatgtccg tcaagcccga ggtctttcaa 2383801 tgatgcgtta tgaatatcag gtgacataga atggccaata ggatttccga taaccccgta 2383861 cagctttttc atacacctct ccccttttct taaattaatg aacgccgaac aaatacatga 2383921 acgccttttg gcgcgtatgc agttaccttt ttatcagcgt catggacagt aacccagcct 2383981 aacccagaga aaacgatatc tgtctttttg tcttttatcg taaacgtatg ggcgaccaat 2384041 tcaggaaact catccatttc atctttaccc ggaggtgtga gcaattcccc tgcatgcttt 2384101 tcataaagcg cgtctgcatt ttcaagtttt gttctatgaa tcatcagctc attcggcata 2384161 tagcaaataa aaggagatct ttccccagac acataatcaa accttgcaag tccgccaaaa 2384221 tacagtgttt gctgatcatt aagctggaat gtgcgaggct tcagctcctt tttaggagat 2384281 aatattttca ggtccttttt attgacataa tgcgccattt gatggttgtt gataattccc 2384341 ggtgtatcat aaagcgatga accgtcatcc agcgggattt caatcgcatc aagggttgtg 2384401 ccaggaaatt gggatgttgt aataatatct tcttcacctg acacttcttt aataatccgg 2384461 ttaataaagg ttgactttcc tacatttgta catccgacaa catagacgtc ttttccgttg 2384521 cggtaatgct caatcgcgtc aattacttct ctgattccct ggccgcgacc cgcactgacc 2384581 aaaaatacgt caaccggttt taagccaagc tctttcgctt cacgcttcat ccattggatc 2384641 agacgctctc ttttcagtga cttaggcaaa atatccgctt tattgccaac taataagata 2384701 gggtttcccc ccaccaagcg ctgcagccca ttaatccagc tgccgttaaa atcaaaaata 2384761 tcaacaattt ttacgaccag agagtccgtt tctccaatac cgtgaagaat gttcaaaaaa 2384821 tcatcatcag ttaaggagac atcttgtatt tcattatagt ttttcagtct gaagcaacgc 2384881 tggcaaatca cattttcttt cgtaagcgat gcaggcggcg cgtaccccaa acctgttttg 2384941 tcctcggttt ggatcgtaac tccgcacccg atacaaacaa ccttttccat ttcttactcc 2385001 tcccactgaa tgtgcccttt tcgtttgaga gcactcagta ttctgcgttc gacctggcgg 2385061 ttaaagcgcg taatgaatcc gtcagaggaa gcgactggca cgaccaaaat cgtatggtag 2385121 ccgtttcggt ttcccccgag tacatcggtc agcagctggt ctccgatgac aacgcagtcc 2385181 tcttttttca gctccatatt gcgcaccgct ctattaaagg ctttacccat cggttttctt 2385241 gctttataga tgaatgggat tccaagcggt tctgagaaaa gtttcactct tctttcgtta 2385301 ttattagaga caattgtcac tttaatgccg tgttccttca tttcttcaaa ccactcgatc 2385361 aatcgcggcg tcgcgttcgg cctgtcccat tcaacaagcg tattatccag gtcagtaata 2385421 attcctttta catttcgttc ctttaatttc tcaggtgtaa tatgaaaaat attttttaca 2385481 aactcgtcag gtaaaaaaaa cttttttaac aaaacccgca cccttccctt tttctttctt 2385541 tcaaaatgat tgtcgaaaaa aatcgaactt gcgcctaaag aaaaactgag caaaaaaatt 2385601 tcgacaaaaa ttgggtttct tcaccaggtg tggataaatt tacacacact atccactctt 2385661 attacatcac tctttagaca aattataaac acgatactca caagttatcc actttttggt 2385721 gtggataaca gaacgattgt tcttatatgc atttcatggt agattaaaga taacttcaac 2385781 ctcagatgaa tgcaacttat cattgtatgc gttaaaatca tgaatgattc caacttttaa 2385841 ggaggtgcct ctcccattaa ttgggttcct agcatgagaa aactgtctga tgaattacta 2385901 atagaatctt atttcaaagc caccgaaatg aatttaaacc gtgactttat tgagttaatt 2385961 gaaaacgaaa taaaaagaag atcgctcgga catattattt ccgtatcttc ttaataggaa 2386021 tttgtctatt ttttccgggc gtatttcctt tttttactca gatgactgat attatatcac 2386081 tttggctgcg cgctttacta ctattttcag caaaaaacac ccctaaaaag aggtgtttta 2386141 aagggccggt tattatgcta accagtatat gccgcccaca acaaggagaa caacaactaa 2386201 aacaacaata aaagcgtatc catatgctct gcctgcgcca tacatgtgaa gcgcctcctt 2386261 aataaggttt tataacagcc tatgtaggag aaataaatcg gactaggcgg ttgtccggct 2386321 caacgctgca ggatctgccc atcttgtatt ccttcatata cgatccttgc ccctttaggt 2386381 gtcatatgat ttccagaagg atctataaga ccagattgga taagcgcttc atcagttgct 2386441 tttccgccgt ctgcttctat aaaatgcttc cagttatcta caagagggac atccaggcgc 2386501 ttcgacacat ctcttgtaat atcgttatat gagttgtgcc atttccttgc tccgcctttt 2386561 ggttcaaaag cagctgcttg atatctggaa tagtaaaaca aatgatgctt cccattacct 2386621 tctataattg ggatacacgt cattaagatt ggcttgatcc cgtgttttct gctttcttca 2386681 ataaaataaa ccagattttc tctaaaacgc tgcttcgaca ctctcggttt cccctcagtc 2386741 agtatggcag cgtcattggt tccgaacata ataaacaaat acttcggttt ttgatccagc 2386801 acatctgtct gaaatcggag acgggcatcc tctgtcgtct gtccgccgat tcccgcattg 2386861 agtatatcaa ggttaccgcg ctcagctgtt tttaatatat tgacccactg ctgtgctttt 2386921 ggataatcgc gataatccca attagagcca cgcgtattac tgtcaccaaa tgctacaacg 2386981 tcttcgtatc cccttccctc gcatcctgct gtaacgaaca gcagaaggaa aaggatgata 2387041 aaatgtttca tctttacacc cccaaaagcc tcactttaat gttatacctc tgtttctctt 2387101 cgttcaatga agagtttttc gctatcactg ttttttccta tagttaacgt gtccccctca 2387161 gtgaatatca ttctgctttc attgcggcgc agctgatgat tttttaaaat tcccttcttt 2387221 ccaatctgaa aaacacacaa accaaagaaa agaaaataac ctgaatccgc actggaaaca 2387281 ggttatccgt taaatcctgc atttacttta acttcgattt aagcttggcc tttgtttttg 2387341 gcccataaat cccgtctgca gttaatccgt tcatgagttg aaaacgcttg acggcattcg 2387401 ctgttttcgg tccgtaaact ccatctatgc cattgttttt ggctccctta tcagggtaaa 2387461 agtgaagtac agctaaagcc ttttgcagct ggagaatgtt tgtgcccttt cgataaggcg 2387521 aagtgagctt tataacccca gacggcagag gatatgatgg tgaagtttct tttggaggtg 2387581 tatccgagga agaaattccg tttagaaaag agttccagtg gtccaagagt ttccgcggac 2387641 attctttccc ggaccacttt ttgtggggaa caacacgatt taacggaata ttgttttcct 2387701 tcatcagctt tctgatcagc cactgggcat ttgatgttgc tttttcaaaa tcgccgtcag 2387761 cattttcaca gatttcaatc ccgatcgatt tgcggtttcc tgtcccgttt gtaccgtctc 2387821 ccgcatgcca gccgttttca tctatcggga gatgctgata aatgactgaa tcgtcaactg 2387881 taaaatgcca gctttcggat gtgttcgggt ttttcacaaa cttggcgtgc attttcgcat 2387941 cagcgccttt ggctgtattc gctgtattat gcaccgtaat ataagcaggc gccatcgcat 2388001 agccaggacg attatcattt gataccggta taaaatcctt ttttatggtt accatttcta 2388061 tccctcccta ttaataagaa tgcagaaaac agagagatgg acagcctttt ttatgaggta 2388121 aaaaagaatt gtgttcttaa cctggttttc agttgaacag ctgaaatggc accagttata 2388181 ctaatttaga tgacggaggt tttgactcct gacatcacct aagttgggag tgaccataga 2388241 catgttaaaa aaagtaatag gtatacttgt gattatcgct atcatttcag ttggtttttt 2388301 tcagaaagaa gcttggcttg atgcaatcaa agcaggaggg atgttttccg ttttatttag 2388361 tatgctgctg attgctgccg atgttttttt cccaatagtg ccgtttgctt tgattgctgc 2388421 tttaaatggc gcagtgttcg ggactgcaaa tggaatttgg attacactga ccggctcaat 2388481 gcttggtaca atattgctgt tttttctcgc caggtacagt tttagagatt gggccagaaa 2388541 aaaagttcag gcctatcctg ccatacaaag ctacgaggct tccttcaaca aaaacgcttt 2388601 taccgctgtt ttattaggaa ggctgatacc tgtcatacct tcacttgtaa tgaacgtgat 2388661 ctgcgggctg agccaggttc gctggcatgt ttttttcttt gcgtctttaa tagggaaaat 2388721 ccccaatatt gttgttgtca ctattgcagg tgccaatttc accagcaata aattattgtc 2388781 tatcagcatt tacggtacat atattctgat catcatgctg gtcatttata aaaagttccc 2388841 tcatcttctg aaggtgccaa aaaaataagg aggcttgttg gcccccttac tttttttctg 2388901 tcgcatggcc tccaaattca tttcgaagcg cagcaaccac ctttcctgta aacgtatcgt 2388961 ctgttaaaga acggtatctc atcattagtg acatggcgat gaccggcgtt gccgtctgca 2389021 gatcaagcgc ggtttccacc gtccattttc cttcacctga ggaatgcata atgcccttga 2389081 tctgatccag tttcgcatcc ttagcgaaag ctcgctcagt cagtcccata agccaagaac 2389141 gaatgacaga accatgattc cacactctgg caaccttctc gtagtcaaaa tcaaattggc 2389201 tgttttcaag cacttcgaat ccttcaccaa tcgcggccat cattccatac tcaattccat 2389261 tatggatcat ttttaaaaaa tgtccgcttc ccgcttcacc agcgtataga taaccatttt 2389321 cgacggcagt atcacgaaaa agcggttcca caatctccca tgcttcatga tcgcccccca 2389381 ccataaaaca ggctccatgc cgtgcgcctt ccattccgcc cgacgttccg gcatcgagat 2389441 aatggatacc cgcttctttc atttgattgt agcggcgaat tgattcttta taatgagagt 2389501 ttccagcttc gataatcata tcgcctttac ttaataaagg tgatacatca cgcaaaacag 2389561 catcgacaat gccatgcggt accataaccc ataggatgcg cggcgggtgt aataaagaaa 2389621 tgaactcttt aagatttgtt gtcccctcag ccccgtatgc tttcagttca tcaacagccg 2389681 cttgatttac atcatatcca accacttgat gattgcggtc aatgaattgc tttcctatgt 2389741 ttatgcccat tttccctaag ccgattaatc cgattttcat atctgttcct cctgattgtc 2389801 taaaaagcct ttactcttta tgttccctat ggattgtatt gtgatacgca gaaaacaaat 2389861 ggggcttaca tcgtctgcgc atgtaaattt tatttttcat gaccgacggc gcctgccagt 2389921 tctattactg aatctcttta tatccataat tatcgcttta tccttgattt accatcagtt 2389981 taagttaaaa tatgggaagg aattcgattt tttcagtaaa aagaaggtga catgttgcag 2390041 aatcaatctc atactcttat tggagttacg aaaaccgctg tattcttttt atacgctgca 2390101 cttgcaatca tcggttttgc aatcgggtat tttattccgc agattgcgaa atgggcatta 2390161 tccctcccct ggatccctct tgaaggacca cttcggctca ttacctcttt tcagggatct 2390221 acagcttcat ttatcactgc tcttctcggt atgtgtgcgg ggatttggtt cgctcattct 2390281 gttattgcaa tgctgctgtc tgtcaaaatt acagatcaca cagtggaatt catcaaagga 2390341 aaaaaagtgc aaacaattca ttccgatgac atcgctcttg tatttatgga tcacaaacgg 2390401 cttgtcctcc tgggaacagc cggatatgaa ttggtacggg aagaaattga tgaaaaacca 2390461 gtaaacgttg agaaggcctt tagacagcat cattacgaat gggcaacaga tggtgatccg 2390521 tttaaagatc aatttcgccg atggattcct gatgcaccag acctatcgca aggcgcccat 2390581 gccttattaa aagctcgtca caaagcactg caggacgaag aaaaagacga tattgaagaa 2390641 ttccgtctcg aactggcaca gctgggcatc gttgtacggg acgaaggcac acgccaatat 2390701 tggcgaaaag cagaaaccta tcccccgaaa attcagctcg gcgaaggatt gtaacaacag 2390761 aggctcaaga aagagcctct tctttactac tgcacaataa acagcactct ggtaccgtca 2390821 ggatagctgc tcatttgatt ccctacccac gagccggcgc cgcgattatc agaaggcgtc 2390881 acatatcgga catcagcccc tgcaccgcct tcctcgcaga ccgccatcgg ccactcatcc 2390941 cggtcatagc ccggcttggt cgggattccc tttaaagatt cctcccgcct tttgtctgct 2391001 ccatctctgt caatggtaca aatatctgga tgtccctctg caatcgcatc cctaatatga 2391061 ctgccggttt ccggataacg agacagcgga aaatataaca ctttgtcata cgaagatgcg 2391121 ccttggatct gttgcggaac cattaaacaa agaagaactg ctgcagcaag aaacaggcct 2391181 gccatccatt ttttcatccc catcccccca tacctttgtt catttcaatg tatgggcgct 2391241 tgatgaagaa tatttttaac atttgaagtt agtatgctgc ttaccaaagc cggactcccc 2391301 cgcgagaaat ttcccggtac agacacagac agcctcccgg tcacatacat ttacatatag 2391361 gcttttgcct acatactttt gtggaggtga cgatggtgac aggtgttttc gcagcgctcg 2391421 gctttgttgt taaagagctt gtctttttag tatcttacgt gaaaaacaat gcctttccac 2391481 aaccgctctc aagcagcgaa gaaaaaaaat acttagagct catggctaaa ggggatgaac 2391541 atgccagaaa catgctgatt gagcataatc ttcgcttggt cgcccatatt gtgaaaaagt 2391601 tcgaaaatac aggtgaggat gcagaggact taatctccat cggaacgatc gggcttatta 2391661 aaggaattga aagctattcc gctggaaaag ggacaaagct ggcgacgtat gcagcgaggt 2391721 gtattgaaaa tgagattgta attacaaaag gggggtgcat acacccctct ttaatacgtt 2391781 tcaatatata tggtgtcaga atccacaatg gtaacttctt tcacgataaa gttaacaatt 2391841 gtttttttat cttcaagagt taagttatct gcaccgattg attgaaaata gtcgatggct 2391901 ctttttagag cattttcact tgagctcgta tcatctagga ctttcatttt tgactggatt 2391961 tcgttacact tttcagtaag ctgattttgc tttttttgca gttcaataat ttgtgctttg 2392021 atttcatcta tgtctaaatc atcgtcatcg cttaggctga ttagcgttaa aagacgcttg 2392081 cggccttttt ttgttttctc tatctctttt tcaataagtt ctaattcatc agacaggtga 2392141 tttgattgtt cagcctcttt aaaagaaaca tacttttgag gatttgtgat gaatttaaaa 2392201 atttcacccc atacatgccg gttcaattta ttctcagaca tttcttttcc gcagccgcgg 2392261 tcctttgcgc cagaataatt tttccggcaa gtatatacat agtagtcttt accatgtgat 2392321 tttcttttct tccctgtcat ggtatttccg cattttccgc atctaaccaa acccgataac 2392381 aagtaattgt gagggctgat actcaagtgt tttcttttac tttgacctaa gagttcttga 2392441 gcataatccc attgttcagc tggaacaatt gctggaattg tcacagtgat ttgttcttct 2392501 tcaggcctta ttttaattat agatttgttc cctgcctgct ttgaaacata ggaaccctct 2392561 gtatcatatt tatactgtct atgttcaccc ttataggaag agttcattaa tatttgccga 2392621 acaacctgcc tgtgccatac tttggcgcct ttttttgttt taacccccat ctgagttaaa 2392681 tgtagagcaa taccatttac tctgccgaaa aaagggcttt tatgatcggt gaaatagtta 2392741 aaaatcatcc gaatgatttt tgcttcctct tctaatatct caagagttct tttctcttta 2392801 acaaatttat agccatatag tttagaatct ttaatgatca tgcctttttt cattttttga 2392861 agtcggccgc ttgatgtccg ttctttgatt ttggcttttt caaattctga gattgccccg 2392921 cgcattgcga aaaacaattg accttctgga gaattggcgt attcaccatt tacaaaaatc 2392981 aaaggtatgt ttcgctttcg caattcgtca tcaatgatta gctgattcat taatttccga 2393041 gaaagacggt caggatcgta acaaatgact tgacttataa gtcccttgct tgcatcctcc 2393101 ctcaagcgat tcaaagccgg acgttctaaa agctctcctg aaaatccttc atctgcatac 2393161 ttcagcacat ctttagtccc tgctttcttt atacaggcct cgatttggct gtcgatgctc 2393221 gatcccttga tcgcttgttc ctcggtcgat acccttacat atattgctat caccctgaat 2393281 ctccttccta taaagtttta ttaaataatg atagcaatcg ttaatgcatt tgtcagcttg 2393341 cggtccctcg atgattatca ctttcataaa atgcatcacc ccttgggtaa tgctatgtaa 2393401 cagctgtttg tccaaatgag gagattttaa attaaactat agtgttatta aacgtttcaa 2393461 tgaatatgca aaaaatttaa aaaaagttgt tgtgactttt ctacactcct ttaggtcctc 2393521 aatagaaaag attttatttt ctatgcctca acattcgctt attatagttt tcaatgattt 2393581 attattattt gagagtacaa tggagtagtg tttttcattg ttagatagtt aatgacattt 2393641 cactggtgtc aagttcgtat agctagacat taataaaaaa aggacacata taaatatgca 2393701 tcctttaaca aaagagttta tttatttccc tgtttcagca aattccttca acctattccc 2393761 tatttcatca cgaactcttt ggaaaaacgc ccatttttct tcttctgtcc cttgtgctct 2393821 tgccggatca tcaaaacccc aatgctcacg ttttacatgt ggaggcgtca tcgggcattt 2393881 atcagcagca tctccacaaa gcgtaacaac taaatcagca ttgttcagaa tatcagaatc 2393941 gattatatct gacgtttgat tagagatatc tataccaact tccttcatcg ctttaacagc 2394001 attcggattt aatccatgtg cttctatccc cgcgctatac actttccact catcacctaa 2394061 atattgttta gcccatcctt cagccatttg gctccggcaa gagttccctg tacataaaaa 2394121 gtaaatgatt ttattctcca tatattccac ctctacatcg agtgacttcc aaagtatttt 2394181 cgttgaaacc ataaagcaac cttaacaagt gctatcatga ctggcacttc tacaagcgga 2394241 ccaattacgg cggcaaatgc tgcacccgaa tgaattcgat atcaagcttc gcacttaaac 2394301 acagcggaat ttataatata tgcttggaca gccgtaaaag ccgaactgaa caatggtatg 2394361 attttgctca tgaattttgc catatatata gacatgaagg cgataaaaaa acaatgcctg 2394421 caacttggac tgattatttg gattggcagt ccaattattt tacatatcac ttttgcattc 2394481 caacttgcat gttgcgtaat atcaaccttc cgtacataca atcacatgca attgaaaatg 2394541 tagcttggtt atttaaggta tccccttcat tcgctaagaa acgtttaagc atttattaca 2394601 ggaaactgac tcaacattta tttagtcaaa ctgttacggg aaatttatgc cccccctttt 2394661 tgtaatgaat aatgaaatcc tcatgcattt gcgcgcattg aaaaaaacaa aaaaagacgt 2394721 ctcccttcac gatccgatcg ggcaggataa ggaagggaat gaaataagcc tgattgacgt 2394781 tttgaaatca gaaaacgaag acgtgataga tacgatccag ctcaatatgg agcttgaaaa 2394841 agtgaaacaa tacattgaca ttttagatga ccgtgagaag gaagtgattg tcgggcggtt 2394901 tggacttgat ttgaagaagg aaaaaacgca gcgagagatt gccaaagaac tcggtatctc 2394961 acgcagctat gtatcgcgga ttgaaaagcg ggcgctgatg aagatgtttc atgagtttta 2395021 tcgggcagag aaggaaaagc ggaagaaggc gaaggggaaa taatgcagaa gaagccggat 2395081 ctcatactcc ggctttctct atttgaaaga gttatgaaaa tcattttttt catcgctgat 2395141 aagctctccg agaaagacag gcaggatcgt aacaaataac ttgacttata atcctcccgc 2395201 aggcattcaa agccggacgt tctaaaagct ctcctgagaa aatccttaga tcggtatact 2395261 tcagtacatc tttagtccct gctttcttta tacaggcctc gatctggctg tcgatgctcg 2395321 atcccttgat cgcttgttcc acgatatatt gctatcaccc tggatctcct gcctataaag 2395381 ttttattaaa taatgatagc aatcgttcat gcatttgtca gtttgcagtc cctcgatgat 2395441 tattaccttc ataaaataca tcaccccttg ggtaatgctg cgtaatacct gtttgtccta 2395501 atgaggtgat tttcaatgag tatgaaaaca aataaaaaaa ccgatggttt gtaccatcga 2395561 tctgttttct atatcactag gccctcaata tagtaaatct agctcattgg ttatgaaagc 2395621 ttattttcat tacacactat atattcattt gttatcattt ctatacgttt atatcaatta 2395681 tggtaaaaaa tggttacaaa aacccaataa acgtccaacc taactttttc atcttattta 2395741 ttaagaattt taacctcttc cttgtgaaat aaagaagcga ttttcatctc caaacagtta 2395801 atgctatttc atcgggacat gtctgttaaa gtagccaata aatacattcg gatatccact 2395861 tacaaccacg attcaatttg atccactaca gatttctgag ctgacattaa acagatagag 2395921 ttataaaaat ctgtaccagt tccctttcac aattaggaca tttcggcggc gtttcggcat 2395981 aatgcgaact aatttattaa tgttcaacaa cagaatttcg tctattggca ataaagaatc 2396041 cacaaatcat tgcaagaatg gccatcgccc accagaacgt tgagatcgcc tgatcatgat 2396101 cgatgataat caaacgaatg acagctgtga tgccaatata aatgaagtag cgaagcggaa 2396161 aatgaaagtc tgatttgaag tatttgataa tcaaagcaat gaactcaaag tacatgaaga 2396221 atataagcag ttctccaagc atctcataat agctgtccac tttgttgaac agtgacttgt 2396281 atacgaatag cacaatgtac caagtctcgc tgatcagaag tgcgcttaag gctaacgcca 2396341 gaaagaacag acagacgttg agaagcgctt gtaacaggta aggcaccttt ttgaatttgt 2396401 tagaaaatct catcatgttg tctcctattt caatatattc gtggttttta ttctcagcct 2396461 acatcttggt gttccaaaat cgtagcacaa tgtagtactt agaattcttt tgtatactgt 2396521 gaaactgtcc ctgcatgcgg gacatcattc gcgcaatgct tctttcaccg agtccgttgc 2396581 tttccggtgt tatatctgca agtttaatcg tattgctaac atggatctca aatatctctt 2396641 gatccgatac aaacgtgata ctgatttttt cttccggatc tgcgtatttc aataagtttg 2396701 acatcacatt atcaaataca cgaccaagct cctccaaatt cacgttaata taggtttccg 2396761 gcagctcgcc tgaaatatgg acccgaaaat gctcctgatg aaggatagca atctgatctg 2396821 atattagatc gtagatcact tctttcactg caacggtctc cagatcggcc tcatattcct 2396881 tgttcagcag gaaatacgca aacagattgt cagacaagct ttttaattgc agtgctttac 2396941 cataagcatt ggctacatac cgatctttgc tggcacccgc ttcgcctccc tcttttttgg 2397001 caaactccag attcatgatc agcgacgtca gcggtgtgcg catatcgtgc gacatttcgg 2397061 taaccaggct gcggctctca gcttgcaatt cctcgatagc tttaagttta tccaggaaag 2397121 ctttccgcag atcctcaatg ctctttgcaa tcatcgctaa ttcatcatgc ccttttatcg 2397181 tcatctcgta gtccagttcg cccccttcaa gaatatgaat ctcttgatga atcgttttaa 2397241 ggtagcgaag actttggcga attccgaaga gaacaatgat taaaaagatg agggttgccc 2397301 cgagcaaatc caatgcaaag gccagatcat aatatcggga agagtagaaa ccgtcgataa 2397361 tgactcgtcc ttcaccatcg ctaaacttga caggatgtga atgattttga gcgtactgag 2397421 tcagcttttc ctttccataa tccgattcgg aataaataga atcatattgc agctcctgat 2397481 ccttgaatat ggtgaggtta atgtaatttt cttttttgac ccactcgcca aacgcttttc 2397541 tatctgatgt agacaactca ttttctgaaa cgtacttgct gaatttttga atgtatcttg 2397601 ctgactcctc gtgataatac tcttccgaac tcagatatcc ctcgatcaga tcatctgtga 2397661 tcttttgcaa cgtcagaaag atcacaccac tcacaatcgc agcaaccatt atcagcaaag 2397721 ccagtttttt ggttagcgta aatttaagat gcgccaaatc gatatcctct tccccattca 2397781 gtttttatat aaaccggacg tgccggatca tcctcaattt tggagcgcag cttccgtata 2397841 tgcaccatca ccgtattgtt ggaacagtaa aagtaaggct gtccccacac actctcatat 2397901 atattttggg cagaaaatat tttgttgcgt ttgttcatca gaagtttcag gatacgatac 2397961 tccagatctg acaacttgat ttgcttctcc tctttccaca cctcattaaa ttcttcgctc 2398021 actcttagtt tgcccccgat aagaaatgtt tcttcctgtt ccttcttttc ctgatagata 2398081 gtatatctgc gtaattgagc aatcactcta gcgtgaagtt cctcttccga gaatggttta 2398141 gtcatataat catcgccgcc ggcgagtaat ccctcagttt tatcgagtgt actcgatctg 2398201 gccgtcagaa acagaatcgg gacgttagag gatttcctga tgtgctgaca tgtttcaatt 2398261 cccgaaatgc ctggcatcat aatatccaaa ataaccaaat caagcgagtc attcacaagt 2398321 tgcaatgctc gctttccatc cttggctctt agcacctcgt aacctgcacg tgtaagggat 2398381 tcctccaaaa gatcaccaat atcctcatca tcctctacga ctaatattcg ataggccatg 2398441 tctctctcac ctcatgattc ttgttgttat ttctcgtgtg tccttactat atatcgttca 2398501 tagtaataag tacgttataa gatactacgt aaatcttaac aatttatgaa agctgatgct 2398561 cgccacaaat ttgtcacatt ttctaaaaaa aatgatgact cttcataaat tgttaagatt 2398621 cggtctttat atttatccat tgtaaggctc aagtttttca gatccgcact acacattgcc 2398681 gtgataaatg ggaaaggagt attgatatga ttgtacaaaa agaaggacgc gggcaaccgg 2398741 tgagtctgcg ggaacgggtt cattttctgg acatcgtacg aggatttgcc ttgcttggca 2398801 ttattattgt caattatttt ctgatcgtag attcagtaaa gggattcgaa atggcctccg 2398861 atgacgtact gcataagctg gtttcctggt ttgccgaagg gaaattcgtt acgttattct 2398921 ccttcctgtt cggagtcggg tttatgatct ttatggatcg agccgcgcag aaggtagaga 2398981 gtcccaacaa gctgtttgcc cgcaggttat ctatcctgtt gggatttggc attttgcaca 2399041 tcacatttgt ttgggtcggt gacatattgg ccttttacgc cgtaagtggc ttcctgttac 2399101 tcgccttcta taaacgcacg gccaaaacgg tgcttagatg gattatcgca cttatcgtgt 2399161 ttcaattcct gactcctgtt ttcacaatgt tgtacaatgt catcaatact gcagggtcaa 2399221 aaaacccgaa tttttcagag tttactttgt ttagccacag cagccttacc tacatggaat 2399281 ccatcagcac tcggtggaca gatatggtca cgatggctgc cggctctttc tctatgatct 2399341 attccatgtt tctcatgttt ctgctgggcg tgtactttgt taagatggaa tttttcaaag 2399401 acatggaagc gaaaaagcct atatggaagc gtatctggat cattagcaca atcgcttttc 2399461 taataacaca aagcagtata ttactagaca tgtttaatct ttctgagaat atgctgtgga 2399521 aggacatttc ctctgtcttg ggtcaaaatg gcggcttaac cggaagtatg ttttatatga 2399581 gcacttttgc aatgctgttt ctataccttc ctcagctgcg aggccctatg atgatattca 2399641 ccaaagtcgg acggatgtca ttgacctgtt atctgcttca ctctatcatt ggaacagttc 2399701 tgttcctcag gtacggattc gggcttgcgg atcatattca atccgccggc acgttcatgt 2399761 tcagtctggc cgtgtacttc gttcttatga gctttagtac attgtggttg aaacggttta 2399821 ggtacggtcc gatggaatta gtatggcgca agctgacgta cggcaaagta aacgggagtc 2399881 ccaaagcaac tccgctgcat tcggaaaaat ctattcagaa ataaccccct tgcacagatt 2399941 gcatgacttc aaattagtgt tgttgaatga agcgggcatt aaacggacag atttgatata 2400001 tggactagtt atttttatat catttaggct tctttgggct aataaatcca ccagagttta 2400061 ctcaatgtgc attgctcatg atcgaatcta aattgaatct tttacgcatg ttcatagtca 2400121 aaggcgcctc attcgactat ttttgtaact tttcgcagga aaaattcgag aatgatgaca 2400181 aatcccgcat acgacactta atacggtagt gaacaatagt aaattagggt tacatgcagc 2400241 ttgttttcca atgaaacaaa gaaaaagaat catacaaaaa gacaggagaa agcttttgaa 2400301 gtattttaac gccaaattta ccgcggaaga aagagcgatg gaatcacttt tttgtgaaaa 2400361 ggcctcgcag agcagctcga atgttttact gaacgactga actctatatt ttagcaactg 2400421 agggagtgaa caatcatgaa aactaaaaat gaaccaaaag ttattctgga actagcaaag 2400481 gaatctgatc tgccagaatt ccaaaaaaaa ttacaagaag cctttgcgat cgccgtgatt 2400541 gaaacgttcg gtgattgcga agatgggccg attccatcgg acaatgatgt tcaggagtct 2400601 ttcaatgctc ccggagcagt ggtatatcat attcttcagg atggtaagaa tgtcggtggt 2400661 gcagtagtac gtatcaacag ccaaacaaat cataattcgc tagatttatt ctatgtatct 2400721 ccagaatatc acagccaagg gattggtctt tctgcttgga aagccattga agcacagtat 2400781 ccggatactg tgctttggga aaccgtgaca ccttatttcg aaaagcgaaa tatcaacttc 2400841 tatgtgaata agtgtggatt tcatatcgta gagttctaca atgaacatca ctctaatccg 2400901 catatgcatc gcaatggacg tgaagatgac aagcccctac tgaatgatga tgactttttc 2400961 agatttgtaa agattatgaa aaaaaaggac taaacaattg aacacggcga gatgccgcag 2401021 agagttgctg gtaacttttt tatatttcat tatcagagga aggtaataat gatgtttaaa 2401081 aggtgttttg atccctgtct cataaacagg ggtcaaaaca cctttgaatc atcggtttct 2401141 tttctgacat ataccacgcc cactagtccc tcaacatagt aaaaacatat catgagttac 2401201 aaaagctttt attcaaagca tatgtttatt ttatttatac ttattttcat catttttcag 2401261 aattctggac acaaatcggg tacctattag aggccaagga actctacatt tcattaagaa 2401321 atacgtactc attgccctgc tttaattaat tttaagccct cgcactatgc ccccccctga 2401381 attaagtatt tgatgtaact ttgaaattaa gtttatgaaa atctgtcaca aacccttatt 2401441 tcataacaca tcatttgttt cagcttccct cgcgaatacc ggattaatgc tcggctttaa 2401501 gatagtcaac caatctctcc gcactgttct taacatcttc ttttgaaaga tgaagtgtcc 2401561 catattgtgt aaacgcagga agaaaacgca ttcctatata gttagcagtg acttgaaacg 2401621 gtctgataag ctcgctgatc gtgatattat attctccgcc tgcttgataa tcagattcct 2401681 gtgcgcctaa ggagatagct aagagtagtt cttttccatg caatttagtt cctccagttc 2401741 cataagccca gccatgtgtt aacacatcat cttcccattg tttgagtaac gcgggactgc 2401801 tgtaccaata cattgggaac tgaaaaacga tacgctcatg atctaacagg agctgctgct 2401861 ctttttctac atcaatgata aaattagggt attcaccgta caggtcatga accgtaatgt 2401921 ctttctcttg ctttaaacga ttcatccagg ttttgttgac aacagacgtt tccaaattag 2401981 gatgtataac gataactaat gttttcatta gactgattat cctttctttg ccaattagtt 2402041 attatttttt acgataatga attgattcta attttaaaat agcaacttta tttacaccta 2402101 ttttatcctt tttcatgaat tcagggcaac taattgggca ccaaaatcaa tgatgactta 2402161 agacattgtt ttgtagaaat ccgatataca gaataatcca ttatttagaa aatttctacc 2402221 ttttccctca atccttacca atttaaactc attaaggaga tactttatca ccaactttaa 2402281 ataataatgg aataagtgct aataaaataa ttcctacaac caacgtagat attattaact 2402341 ccttccatac aatcaaattc tttaaaaaca tttgataaat aactaatgag tttactggaa 2402401 tgttaagcaa taagcccgta agaagtccag gtgcatactt tttcattaca acagttgcga 2402461 taagatgtgg aaaaatagcg ttgataacca tagaacctag aaagccaatg aaaatccatt 2402521 ttgcaatatc tgattctggc atatataaaa aaccaaatgc agataaataa gccaacatag 2402581 ttataacaat gacagcaaaa tgaaattcat ttgaagttac tggcttttga aactttgaag 2402641 attgttgtga ccactcaggt aaccaaatag cttcctcaat attatgaagt gtaatagcaa 2402701 aacaaaaaaa tgctacgaaa taaaccacct atcatttcct cctcggtgcc acaaccaata 2402761 tggtttggca acattatatt acatttgagg ctgattggat atggtgttaa aagagagaag 2402821 aatctgcctt agtagttgct tcttaattat atgtgcaata acgtgttgtt acgtggcatg 2402881 tcatattcaa atataataac tctaaagcaa acaaagatac ctatatagtt tggcatcctc 2402941 ttttttagtt cgagtccctc tatttatttt gggcacaaaa tagacataat ttatattgac 2403001 tcattatacc catcacatac catacccctt aaaccaatca ggattaaaat gttttaaaaa 2403061 aggtgatcaa agattaagtt atggtctctt ttattttatg tatgctgtct taatgcaaaa 2403121 caacactgga caccactaag tcaaatgcat ttcatggtac tatagtcaag acttgtccaa 2403181 gtcaccatta tcaaaatgaa tttcatcaaa cacttgaaac atttattgaa cgcggccaag 2403241 tgtcataaca ttaataagaa accaacgagt gatgaatctt ttaatctttc attttacccg 2403301 ctggctcata tcaaaggagc tctaaccaaa ttttaatagc tgtcgcacct attaattgcg 2403361 ctaaaaccca ttgcaggaat tttgtattta ctttttgccc aactgatgcg ccaataggag 2403421 aagctattaa actagtaatc ataagaacca gagctggtac aaaaagaacc tggcccgtga 2403481 ttacttttcc aactgttgcg ccaatggatg aaagaaatgt aatcgcaaga gatgaagcga 2403541 ctgtgactct aacaggaata tttaaaatcg ataacataat ggggactagg ataaaggcgc 2403601 cgccagctcc taaaatacct gatacgccac caatgataaa cgctaaggaa gaagccaacc 2403661 atttattaaa tatcacttcc ttatcttcgc tatgttcttg tcctttctgt ccttttttag 2403721 gtataaacat taaaataact gctataatag ccagaattcc gtatataaag ttaattcctt 2403781 tttcagatat ataatgagaa aagtaactcc ccaatacact ccctaaaagg atgctgcttc 2403841 ccatgtaaat aattaatgtt ttatttataa gaccactctt acgataagcc caaacaccgc 2403901 cgagtgtcgc aaaaaaaact tgaatagccc ctatccctga aacttcatgg gcagttaatg 2403961 acatcactcc cactaaagaa ggaatgtaca atagcattgg ataattaata actgctccgc 2404021 caataccaat cattccggaa ataaaggcac caataaaccc tataatgaaa agagttgtga 2404081 taaaggcaat atccatttta tttgcctcct ttcataggaa aagggtatct ttctattcga 2404141 taccctttca cattcattag cctttttgaa tccaaaattt caatatatcg ccctcgtccg 2404201 tttgctctaa aaggtcatgt ccgcctgatt tagaccaggc tgtaagatca tttttggctc 2404261 ccttatctgt tgcatgcact tctaatattt gacctgattc cagttcattc atcgcttttt 2404321 ttgttctgac aattggcatt gggcatgcca agccttttgc gtctaatact ttatctgatt 2404381 tcatgttctt ctctcctctt tttagcagaa acttgtgtta ccgtattgca cagcggtttg 2404441 ggccaatctc catttcacgc tgtttttctt catctgggct gattttcccc atgtttgttt 2404501 ctcgaatctc ttggtatgca tttggttgcg gaggcaaatg atctgttact aggtgtctaa 2404561 attctgtttc atccgcaatg ttcaaaccat ggttctcgct aaataatgta cttagttgtt 2404621 taccaacact tccattctca tttagctcgt caatgatcat aaagtgtgcc ggtaatacaa 2404681 ttaaatcctt tgataacgct ttgtaacggc tataaagcgt ttttcttaaa tctcctaccc 2404741 aatcttctgc cataccggct aagtctggtc tgccgattga atcaataaac aagatatcac 2404801 ctgaaagaag atactggtca tcgacaatga aagaagtgga gccaatcgtg tgccccggag 2404861 aataaatcgg ttgaatttta atcgttgtat ttccaataat aatgtcattt ccttcttcca 2404921 acggctgata atcgaattcc acttcttcag catctttagg cggtaaccag taggttgctt 2404981 ttgttttttc agcaatgact ctgccgcctg aaatatggtc cgcgtgaaga tgtgtatcaa 2405041 atacgtgagt aatcgttgca cccttcccct tcgcaaaatc tataaagaaa ttcaccatac 2405101 gtgtcgcatc aataattgct gcttcaccat tggaaatgac catgtatgac aagcagcctt 2405161 taccgattcg aacaaactga tacatctcac cgccatcttt taaatccccg acttttaccg 2405221 gctctaaatg ttcgctccat gctttcattc cacccttaag gtaggataca gaatgacctg 2405281 cttcagaaag catttcggat accatgacgg atgaaccttc ttttgcgcaa acgaccagca 2405341 cttctttatc agaaggaatt ttctccaaga tatcttctac gccatctaaa agatcaaaat 2405401 aaggaacatt caaatggtca aagtcatgcc cttctatctt ccaatcacta aaatcatttt 2405461 cattacgcac atccaaaata aataaaggtt ctttgttaaa gatttttttg tcacttcttt 2405521 tggggtcatt gcctttacgg tcatgtttca atacctccta tatcaaatct tttagcggga 2405581 ctaaaacgtt aaggatacat cagcatcttt cgtaaaacca aaaaaggtaa cagccccgcc 2405641 tacttcgatt ccttccataa aatcatcttt tgttaaaccc ataacgtcca tcgttatttg 2405701 acaaccaaat catgcaactc ccatttcaat cagttaagaa tagaaggcac atttgcgttc 2405761 ctacaacctt ctgcgacatg ctcttttcct tgtcgcaata ttacagactt tataagcatc 2405821 aaacagaccg ctatttgccg caataatcgc tactcttgta ctcatctgtt catcatgctt 2405881 tttatttatt cggttttacc tgtccaatcc cgcatacccg ggacaacatt aataaccttt 2405941 ttaaaacctt gttttttcat ggtgcgggcc gccatttcac tccttcttcc cgaatggcag 2406001 ataatataaa tttcatcatt ttcgtttaat tcgttagcgc gcttttccac ttcaccaaga 2406061 gggatatgca caactcctgg gatatgagct ttttcatatt cctctatctc tcgaacatct 2406121 aaaatgttaa gagactcgtc actatctact ttctgtttga aagcttctaa tgaaatctca 2406181 ggaattgaag atgcattttc tgatgaatgc tctcctcctt ttcgaagaaa atgacgaagt 2406241 atttctccct ctgcttcagt acccagatat tcatggcctg tactttttgc ccatgcttcc 2406301 agatctgctg tagaaccttt atctgtcgca tgaatttcca atacttcacc agcttttaaa 2406361 tccttcattc tcttcttcgt ttttacgata ggcattggac acgccaaacc tttagcgtct 2406421 agtacaatag ttgctttcat cattttttcc tccttttctt atataggggt gggggtatac 2406481 aaatatacaa aaagtttctc actgtaagtt aacaccatgt attcataccc ccttttatat 2406541 ttgtgatgtt tttaaatcct tgtttcttca atatttttac ttgcctttaa acttctcatt 2406601 ccgcttagca atgagtaaat gagtaacatt agataaataa gttgacactg ccttcctcag 2406661 catctgccaa ataagctgct acaccagcat agtcaatatc atctaatagt tctttttcct 2406721 gtaaaccaag aagatccatt gtcatcgtac aagctacgag ctttaccccc tgttcttgag 2406781 ccatctcaat caactgaggt aaagtaagta cattatgctt tttcatcaca tttttaatca 2406841 ttttagggcc catacctgca aagttcattt tagataaacc catcttatca gcaccacgag 2406901 gcatcatctt tccaaacatt ttttcaagaa atcctttttt cactggaatc agctcttctt 2406961 tacgtaaagc gttaaatccc caaaaagtat ggaagatcgt cacttcatga tcgtaggcag 2407021 ctgcaccatt tgcaataata taggctgcca ttgctttatc ataatccccg ctaaataaaa 2407081 caattgttgt gcgttttgtt tgttctgtca tgtttattct cctaactaat tacccctgcg 2407141 ggtatattaa agtcaaaaaa ttttttcgaa agatctgctt ttattcaact ctttaaatac 2407201 catagggggt ataatataac gcatataaaa attcgtcaac cttaggttga tgaattttta 2407261 tcggctcttt accaataagt cgactgcttc ttttactaaa ttttgtgtgt cttcgccttt 2407321 ttctaaactt tcacgaacac aatgttcaag gtttgtgctc acaattaaac ccatcgctcg 2407381 atcgatcgca ttacgggaag ctgctaattg ggtcacaacc tctctacaat cttttccttg 2407441 ttccatcata gtcaatacac ctttaatttg tccttcaatc cgtcgtaagc ggtttttaat 2407501 cttttgatca tactccatat atcaatgaaa tcctttcttt catttatttt tacatttaca 2407561 tgttgccagt tcataactgt ttacatggat acctttgcgc tttagaaaac gcactcctaa 2407621 atttaattcc acccggtcac gagctattat gtgtatttta tcacgtggaa tctctaaata 2407681 aaaacgtttt agatacgcat atgggatgtt taaaataata ttatccgaaa aattggctac 2407741 atcgttataa tgacgaatat ctaatattgt gatgtccata gcctctaatt tatctttatg 2407801 gatacaagag attccggtta taggataata acgtctatac gttgcaatga taatcacaaa 2407861 aataagcagg aatgcaataa ctaaataatt gatactattt acaccacctt attaactctt 2407921 tgtttattca caaaacaata atataccccc ataggtatat agtcaagtgt gaaagttact 2407981 ttctttgagc tgatagattc atttcgatat ccgcggattg aaaaaatact tacattcgat 2408041 aatgccaatt ctgctaaaag gaactcgaat aaagcaataa gccgatttaa ttttaaatcg 2408101 gctttattta tcaattactt aaaattagca caagacacgc tgcttggata ttaaatgggg 2408161 tttcattagc atggtactgg ttccccatgt ttcatgctgg atgtgacttt aattattcta 2408221 gaattctcca gaatatctgt gctaatcttc cgcagccact gcatctgctt tggtttcatg 2408281 aactgtacca aatggatggt taggaggagc ataaatggag taaagtttta atggcgtatt 2408341 tcctgtatta attacgttgt gccaagtgcc ggcagggaca acaatggcag aatcatcata 2408401 gacatttctt tgaaagttca aatgatcttt gctctttccc attttgacga tcccacgccc 2408461 ctgctcaatc cgtaagaact ggtcaacgtt aggatggatt tccaaaccaa tgtcttctcc 2408521 aataccaaga ctcatcaaag taacttgaaa atgctttcct gtccataaag cagtacggaa 2408581 cgtattgttt tgttttgtgg ctctattgat atttacaaca aatggttttg gtccataatc 2408641 cttcaaaaga aggtttctat cttcatatga agagcgcaaa tcggcacctc tgtgtacttt 2408701 ctccatctca tttggaatag tccaataaac agatcttcca tcattataca tcggcacagt 2408761 cacataataa taacattgag gcgaaaaagg gttatagtac attttttgat ccccgcaatt 2408821 ataaattttt gtgatagtat cctatgcatt tattaaggga gtgtgctaaa tcaagaaaac 2408881 tcatattaaa cacaaaaatg aatgttcgat caccgtttga ttcatggatg aataatttat 2408941 caccgacctt gtaatcgttt tctagatgtt gaatttcact agcctttgtt aacaagacat 2409001 cgaatgacac ctttatatga tggattatca aaggtcgacg atcctaaatg gcttttgaac 2409061 atttacatag cacaacaaca gagtatacgg aattctgttg tttgtccccc ctatcccagc 2409121 tcttttagat ttatctcttt ggatgcgcct tgatggccag tttttcagca gcatagaatt 2409181 tatcccctcc tgaatcgtta tagcatattt caacgccgat agacttgcgg ttcccagtgc 2409241 cgtttgtacc gtctcctgta tgtgggctcg cttttagtaa accagtttat attctttttg 2409301 ggcacacaac agaaacaatt ttccatatga aaatctcgta attttacacc tctttaactt 2409361 gaaggaggat ttttgcatat gtattttcat acccgtcaac taccatctca tccagcatat 2409421 attcctcata tgcattttcc cctatttgca ttccatttct ttcaatgaac tcaatgattc 2409481 tccggtacgc ctcttcagta tttccgccta tttcatatcc aactgcatac aggccttttg 2409541 gccgtacatg ataatttatg ttctctgccc catcttttac ttttatataa aagtaactgt 2409601 aattgtagaa gtctttttct aagatttgtt cccgtgcaaa gattccgcct atcggatatc 2409661 cttcatctaa ttcatattgc tgaacttcat gaatgagttc tgaaatggct gccacatatt 2409721 ttcgttctgg taagtttaat gtttttcggc ttaacatgaa tgtttcttca tttaaatatt 2409781 caaaagaaat tgaggaaaaa tcagtctcaa gtgcttgttc tgtaagcgtc acttttgttt 2409841 gtaagatcgt ttgcaactgc ttaagctcat ttattttttt atcaatctca atagactttt 2409901 cttttagaac atgcaggatc ttgtctggtg tttttccttt tattagacac tttatttctt 2409961 ttaatggaac cccaagctct ttaaatagac tgatgacttg aaaagtctca aattgatgat 2410021 aggaataata tctataccca ttttcttttt ttatttccgg cgagaaaaga ccaatctcat 2410081 cataatgaaa taaagtttgt ttttttacac ggcagagctt cgaaaactcc cctgttgtga 2410141 aatacttctt aacatcttcg ctcataaaaa cctccttgac tatacggtaa ccatatacct 2410201 tatgatttga ttgtacttga aaaaagcttc aagcgaaaag gataggtaaa aagggttcaa 2410261 ttgagtaaaa ggggaattca gatgaaaaaa tcaataaatg agcaaaaaac gatattcatt 2410321 atactattaa gcaacatctt cgtagcattt cttggtatcg gtttaatcat tccagttatg 2410381 ccttctttta tgaaaatcat gcatttatcc ggcagcacaa tgggttatct tgttgcggct 2410441 tttgccattt ctcagttaat tacttcacct tttgcaggta ggtgggttga ccgtttcggg 2410501 agaaaaaaaa tgattattct cgggttgctt atattcagtt tatctgagtt gattttcgga 2410561 ttagggaccc atgtttcaat attttatttc tcgaggatat tgggtggtgt aagtgcggct 2410621 tttatcatgc ccgcggtaac agcatatgta gctgatatta caaccctaaa ggaaaggtca 2410681 aaggctatgg ggtatgtttc tgctgcaatt agcaccggct ttattattgg acctggtgcg 2410741 ggaggattta ttgccggctt tggtatccgc atgccgtttt tcttcgcctc cgccatcgcg 2410801 ttaatagcag ctgtcacttc cgtttttata ctaaaagagt cattgtcgat agaagaacgc 2410861 catcaactct catctcatac aaaggaatca aatttcatta aagacttgaa gagatccatt 2410921 catcctgtct atttcattgc atttattatc gtctttgtaa tggcttttgg tttatcagct 2410981 tatgaaacgg tattcagctt gttttctgat cataaatttg gcttcacacc aaaagatatt 2411041 gcagccatta ttacgattag ttccattgtt gcggtagtta ttcaagtttt actattcggg 2411101 aaattggtca acaaacttgg agagaaaaga atgattcagc tgtgcttaat aaccggtgcg 2411161 atcttggctt tcgtgtctac tgttatgtca ggatttttaa ctgttttgct tgtaacttgt 2411221 tttatttttc tggcgttcga tttgctacgt ccggccttaa ccgctcattt atccaatatg 2411281 gccggtaacc agcagggttt cgtagcaggc atgaactcca catacaccag cctgggaaat 2411341 atatttggac ctgctctagg cggtatacta tttgatctta acattcatta tcctttcctt 2411401 tttgcaggtt tcgttatgat tgtcggcctt ggtcttacaa tggtttggaa agaaaaaaag 2411461 aatgatgctg cagctttgaa ttaattcatt ttctataaag ttaagtcatt tggatgcagg 2411521 gaatgcccct ggttaggcac aataagaaaa ggtacttaat ttgataggct acatgttgct 2411581 tgacgtgaat atagtataag ctgagtttta gcaatatcag gataccggga taagaaaaaa 2411641 ggagaatgta gtatgagtat aaacataaaa gcagtaactg atgataatcg tgctgcaatt 2411701 cttgatctac atgtcagcca gaatcaatta tcatatattg aatctacaaa agtatgttta 2411761 gaagatgcaa aagaatgtca ctattataaa cctgtcgggc tttactatga aggagatcta 2411821 gtcggttttg caatgtatgg attgtttccc gagtatgatg aagataataa aaacggacga 2411881 gtctggcttg accgattttt tattgacgaa cgctatcagg gaaaaggatt agggaagaaa 2411941 atgcttaaag ccctcattca gcaccttgct gagttatata aatgcaagag aatttattta 2412001 agtatatttg aaaataatat tcatgctata cgcctttatc aaaggtttgg ttttcaattt 2412061 aatggtgaac tcgactttaa tggtgagaag gtaatggtaa aagagctata gatatccaag 2412121 cctccttgtt tgctgagaaa cgtttgaact tcgataatga ttacctactt aaactgcaag 2412181 atcattgttt aaaaaagcct ggatgaaaat ttcatctcag gctttaagca tcttattagt 2412241 caaaatctca tgtgttttat ccagatgtta ttcttttttc cggacaattt ctaaataatt 2412301 aatatgccgg ccaactgttt cgtgcacttt aaaaatatac ccatcggctt ctataacgga 2412361 cccaactgca gcgtctattt gttgagtcat aaaccagccg cctattgtat ccacttcgtc 2412421 acttgctaac gtcgttccca ataaatcatt tacatcttca atgagcactt tcgaatctaa 2412481 gatatagtga ttatcattta cttttctaat attaggcact tcatctttat caaattcatc 2412541 tctgatttcc ccgacaattt cttcaagaat atcttcagca gtgactaaac ctgaagtgcc 2412601 gccatattca tccacaagaa tagcgatatg tgttcgctct ttttgcattt ttaccaatac 2412661 atcatgaatt ggaacggatt caataacatg gataacaggg ttgatatgat tttctaactt 2412721 gaaatcctct tttatcttct ggtctgtgtc aatataagct gacaaaaatt ctttagcatt 2412781 gataaaacca atgattgaat ctttatctcc atttaggact gggtaccttg tatagctctc 2412841 tgtcttaatg atcttaacaa tagtttcata agaatcctca ctagaaatcg ctacgatctc 2412901 tcttctcgga atcataattt ctttggcgat tctttcatca aattcaaaaa tattatttac 2412961 atatttcaac tcattttgat tgatttcacc gctcttatag ctttcagaca gtaagatgcg 2413021 cagttcttct tcagaatgag caagttcatg ttctgatgca ggtttcaaac cgaagagtcc 2413081 tactataaac cgggctgaac catttaaaaa ccatataaaa gggaacagga tgcggtaaaa 2413141 ccaaataatt ggctttgcag tcaaaagagt gatggtttcc gctttttgga tagcgagtgt 2413201 tttaggagca agctctccaa ctacaacgtg caaaaaagtc gccatcacaa aagcaatcac 2413261 taagatcaat acatgtgaga ctgtttcact tacatgaaaa tgagcaaata aggggtgcaa 2413321 aatcacttca aaagtcgatt ctccgaccca gccaattccc aacgctgtaa ccgtgatccc 2413381 taattgacaa gctgacaaat attcgtccaa atgagtaatg acctttttgg ctgatatggc 2413441 accttttttt ccctctaata tgagttggtc aatttttgat gacctgatct ttactatcgc 2413501 aaattcagtc gcaacaaaaa atgctgttaa gacaattaaa agagtaaaga ttataaggtt 2413561 aatggttgtc aatgatttgc cttacctagt aaggcgtaca cctccgatgt aaatatttat 2413621 tgaataaaca aaaaacagta tatataacat tataagttca aaagaaccta aaatcaactc 2413681 tgaatgatgt aaataatcat ctttttccgt atggagagtg gttcccatag tcttcaacta 2413741 acgattagtg gcgttttaag gcttaaaaaa gaaagcaaaa taaaaacaca cctgaatttt 2413801 ctggtgtgtt tcaataatac ccaaccgtct tgatttattt aatgtcttta taaagatttt 2413861 cttttaaaat ttgaatcaat tcggcctgtt gctttatatt tttgcggcca tttctattaa 2413921 ttgcagcaag ttcacagaca attccagctg aaatgaaaaa caataaacct tcaaacattt 2413981 taaatccccc actgtctaag tgatagtcaa atttgttttt tctttttgca atacctgctt 2414041 ataatcttcc ttacgctgat atatgttatt taaaatgagt ccaataatga caaacagtgt 2414101 tcctactata tcaaaagcag ttatgttata tcctttgatc accatgatta acaatgtagt 2414161 aatggggaca aagttaataa ataaaatccc attaatggat gataggattt taatgccata 2414221 gttccaacta aggagggcta tgatacctgg taaagtaatc ataaataaaa aatcatactt 2414281 aattgctgca atcactttaa tactcggtac cgacacgtaa ccttgcgcgg taagtatagc 2414341 tgtcatgatt cctgttatag ctgtgccgaa taaacatgtc aaagttgaat aacgaagtgt 2414401 ggaccactct cggaatatct gtccccccat tgtgtagaca acccacccta aaacaccaat 2414461 gaatataaag agtatcgaga atagatgatc ccctaatgaa aaaaagaaac ttatattacc 2414521 tttggttatg accatcgaag cccccaaaaa ggcaatcaat atactgatca ttgtgtattt 2414581 tttaggtttc acatgtttat atccccatag aataacaatt gaaagcatcg gcatgagtgc 2414641 ctcggcaatg gatgctgtca taattccaga cttccccatc aacctttgac ctaaaaaaat 2414701 aagaacattg tatatagtaa acgccatcac cccaaataaa atgatccatt ttgctttacc 2414761 ctctaaatga aatgatttct ttccttctct caccaataat aaaatcacta acataatcgt 2414821 taccacaccg tagcgaataa atgaaaaata aaacggatca acaaattcta atgcatgatc 2414881 tgcaactgga aacatcgcgc cccaagacat acttgctact aaacatgtaa gggcaccaat 2414941 gaataattga ccttttttca ttgaattccc ctccttttct ttaaaattac aatgagaatt 2415001 ataaaaagaa gtaagcatca agtaaaatga acaaaagtga tgaaaaacat cattgataat 2415061 gatactttaa tgaagggggg atcttcatgg aactgcgaga cttacaaatt ttcaaatgcg 2415121 tagcccatca caagagtatt accggtgctg caaaagagtt aaattatgta caatctaatg 2415181 taactgcgcg gattaagcaa ttagagaatg agctcaaaac acctcttttc aatcgccata 2415241 aaaaaggggt ttcactaagc ccagagggcc gaaaaatgat tgaatacgtt aacaaaattt 2415301 tgaaagatgt tgaagaactg gagcaagtct ttctagatac tgaaataccg tctggaatat 2415361 taaaaatcgg tacagtggaa acagtgagga tactgccgac catcatagct tcctattata 2415421 aaaagtatcc taatgtggat ttatcattgc aggctggtct aacagaggaa cttattaaaa 2415481 aggtcatgaa tcacgaatta gacggagctt ttatttcagg ccccttgaaa cattctattc 2415541 tggaacagta tgatgtttat actgaaaaac ttactcttgt aaccagtaac aaaacgttta 2415601 atatagagga tttttcaacg actccgattc ttgtttttaa ccaggggtgc gggtatcggt 2415661 ctaggcttga acaatggctc aaagatgaag gtgtgctccc aaacagaatg atggaattta 2415721 acatcctaga gacaatctta aatagtgttg cacttggact cggtataaca gtggtaccgg 2415781 aatctgctgt tatgcatcta gctgtacaag gtaaggttta ttgccaccca ttgcctgaga 2415841 aagacagctg tatctcaaca atttttatac gccataaaga tgcgtacctg acaaattcaa 2415901 tgcgcagcct cctaaagacc attgttgaac ataaaaatat gagtatggct taaagtgatt 2415961 tttctctttc tatattctaa cttcttaaat aaaagagaag gctcatctcc acttcgctac 2416021 ccttattcac gcaaaaaata gagcagtaaa catgtgagtt actgctctgc ttcgtttatt 2416081 caccgttcat ttgttttaca atgtattcag catcatttcc tacgccttga agcaacgctg 2416141 aacctcgctt atgctgccaa ggcaaaccta taaagtacaa tccttctaca ggtgaaacac 2416201 ctctatgatg tatgattcga ccttcttgat ccaaaacacc ttttatattt atccaacata 2416261 agggattcct gaaaccagta gcccaaataa tattgtttac ttctaatgta gatgaatctt 2416321 taaaaatgat ttcattttgc tttgcggcaa tgactctttt ttttaagatg atctccttct 2416381 gttttattgc atgttttaat tcatgcccaa atactggatc acctttcttt tgaatgaatt 2416441 tgcctactat tgatgtatga cttgcatgta aaactcctag tttatcaaac caccaaaaga 2416501 tgcttctttt tccgatcatt aaagggaaat aaacaagttt attactacaa gctaaatatg 2416561 taactctttc tttggataat tcaacagcta tttgagcacc actattccca ccaccaacta 2416621 ctagtacatt tccatatgcc aattgttttg aattcttata ttgtgatgag tgtagttgat 2416681 taatattatc ggataaatcc tttgatattg atggaatatt aggggtatga aaaggccctg 2416741 tagcaatgac aagattcttc gtttgatatt cttcccgatt tgtttttatt aagaaataat 2416801 tctttatttt taggacactt attacttctg tccgtaattg gattggaatt tcaaattttt 2416861 taacatactt ctttagataa gcaacaattt cattttttga aggaaatcca tgtttttctc 2416921 cttcaagatg cattccaggc aaagagctat acattcgaga agtaaataaa actaatgagt 2416981 cataccgatc tttccagctc tcccccacct catgactttt atccaaaatg ataaactttt 2417041 gatcggactg cttaagataa tatcctattg agatccctgc ttgaccagcc ccgattacta 2417101 tagtgtcgta cacattatca ccccgccaat ttcaaattgt cagtagacag aatctgcaaa 2417161 atcctagttg atctcctcac tataaagtta gataaaaaat ttaatggtga tggtggtcac 2417221 gctgcttctc cattttgggc tgacaaagga tcgcattgtc gtggttatgc gcttcggttt 2417281 ccatttgaat ggttacgtgc gtaatgcctt tatgctcaag ttcatgttca attttgcgta 2417341 aaatattttc actttctgaa atggtcagtt gatcgtcaac aactgcgtgg caagaaagag 2417401 cattcaatcc gcttgtgata gaccatatgt gtaaatcatg aatgttttga attccctctg 2417461 tcccttcaat tgtacgaatg atatcagaga catcgatatt ttctggagtt ccttccatta 2417521 agatgtgaat ggaatcttta gtcacattgt aaccgcttct tagaacaaga atagccacaa 2417581 tgatactagc caatggatct gcccagcccc atccaaagaa gatgataagt atggcagcta 2417641 aaatggcacc tacagagccg agcatatcgc ttattacatg taaataagct cctcttatat 2417701 tcagattatt ctttgtatct ccgccactca tcataatcca agcgaccaat agattcacaa 2417761 ctaacccgat gatactaatt gtaagcatgc cggttgttgc tacttttggt ggattagaga 2417821 agcgttcgat tgcttcataa atgatataaa gagaaataag aattaaggca gcaccgttta 2417881 tcacagctgc aagaatctca aatcgtttat agccgaatgt cttattgtga tttgcctttt 2417941 tttcagctaa tgtaaaagca atcagggcaa ccattaatga aattgaatca ctcagcatat 2418001 ggcctgcatc agataaaagc gccaggctat ttgttaaaaa tccacctata gcttctataa 2418061 tcatataacc tgtaatcatg ataaaagaga tcaataaaac ctttttattt gctccttcat 2418121 tatgattgtg acccataaaa aactcctcct tacctaaagt ttttaataca tatgtattta 2418181 ttatttcaaa tctgttatga agcattctaa catgatacaa ataatattta tatatgagca 2418241 tgtgttcata tataaatata tctgctcttt actgaaatgt caaaatattt ttatagaaat 2418301 ccacaatacc tccttaatta ttcttttata aacataaaaa agcggagcaa acacatggtt 2418361 tgctccgcta ccctagtttc tctatccttt tcttcaatca agcatttgag ggtagtattc 2418421 aactacaatt tacctgttaa aaattgggcc tcaccaagtc caaaactcca gtcagcatta 2418481 tcattttcaa caatagatac aattaaatca gttgatgcga taccacactc agattccagt 2418541 ctttcagcta acagcctgta aaatttttgt ttcttctctt ccggtcggga tttacttgta 2418601 actgaaagaa caacaagatt tttagttcgg ttaaatccta acccagtatc ctcaataatc 2418661 atatgatttt ctggatgttc atgaacaatt tgataacggt cttgttgagg cacatcaaaa 2418721 gcctctacta caacattgtg agcgacatct aaaagttttt tcaaacttga ttgatctcgc 2418781 ccttctatta agtcaaaacg aagtaatggc ataaaatccc ctccttctac tacaacagtc 2418841 tttttaattt cattcgttaa tgtgtcagct atttccaagc agctgctaca tttagaaaat 2418901 aaagtaattt cccaataacc ccttcattct ggtgttagtc aagcctatgt tatgatgtgt 2418961 atttccatag gcaatataca gaatcaactt cgagtaatta accatttttt gaaatagctt 2419021 tatcacttac tttagaaatc atttattctt ctaagcttta gtttacatga agctctgcta 2419081 tcatatataa ttcaaaatta agatggaaga catctcaaaa tcagatatca actatggagg 2419141 actagatgaa tattcagttg ttacaggttt ttctcactac tgctcgtgaa ggcagtattt 2419201 ccaaggctgc tctgacttta aattatgcac aatcgaatgt aacgaataag atacaacaac 2419261 tagaaaacga tttacagaca aaattattct atcgtcatag tcgaggaatc acacttactc 2419321 ccccagggca aattcttgtt tcttactcag agaaaattct acatactatt gaagaagcta 2419381 gagcagccat gggcgaatca tccgcgcctt ctgggccact gcgtatagga tcaatggaaa 2419441 caacagctgc agtttggctt cctcaactcc ttgcacatta taataacctc tatccaaatg 2419501 ttgatttgaa cctagtaacc ggccctacgg aacaacaaat acaagcagtt ttacattatg 2419561 agttaaacgg cgcttttatt tcagggccta ttgaacaccc tgatttagtt caagaaaagg 2419621 tattggatga agagatggtt cttgttacaa gtgcttcaca ccctgtgatt tcttccattc 2419681 aggatgttca aacacaaaca atgcttgtat tccgtaaagg atgctcatac agagcaaagc 2419741 tcaatcatat cctgcaagaa gaaggtttat tacctataaa attaatggaa tttggcatac 2419801 ttgaagcgat cattggctgt gtaagcgccg gcttggggat ttcactgctg cctcgttcaa 2419861 tcattgcttc gcatgaaaaa gaaggccgca tccgcagcca cactatctct gacaaatatt 2419921 cttttgtatc aactatgttt ataaggcgga aagacacttt aattacccct gctttatctg 2419981 cttttttaac gcatatgagg gatcattttc agataaagag gccagatcaa tcgtaaataa 2420041 atggatggaa ggcatgcttc gcctcaaaat acccctgatc agttgtctga tataaaaata 2420101 taggcgcatc tcaatgtttg tatagagcaa aaaagcaaac ttcggtatgt agtttgcttt 2420161 ttcttcgtga ttttgcactc tgaatcgtga aacctagtcg atattaggat gtagattttc 2420221 ctcattcaaa gaattttgaa cgaaggtcat tgccctagac acttggttgc gtcttgaagt 2420281 taaaggctga ctatttccta aagcgtcaat cgctctcaca actattaaat attcacctac 2420341 agatttcggg tgacaacggg aagattgata ttttcggttg gacaggggca gaacatccaa 2420401 ttgtaacagt tgaagtatcc actgatggag gagatcctgc agatctgagt gatattgctg 2420461 ttgattgatc aacttgtttt tgttcggaat atactcagta tatagccgca tattcctcct 2420521 gcaatagctg gaatgagcca ccccagccct atgttataca taggaagaat ctgagtgaaa 2420581 atacgattca caacttcaat ttttattcca gccgccttca aaccgtcaaa taggctgatg 2420641 atgaatgcga ataataaact gccttgatac acttctgtct tccctttaaa tacagaatgc 2420701 aaaaacgtta aaaatattaa ggaaatcgcg ataggataca tcgtcagtaa gacaggcatt 2420761 gacaccttaa tgagctgggt taatcctata tttgcgacaa gcgtactaaa cactgataaa 2420821 acgacagcaa tttttttata agaaatgttc ggaaataatt catgaaaaaa tgaagaacac 2420881 gctgtgatca gcccgacact tgtcgtcaga cacgccactg taatcattaa gcccaataag 2420941 attgaaccat aagatccaaa ataataggat gaaaccttag ccaaaacctc tgctccattt 2421001 tctaaaatcc ccagttcttc aacgctggaa gcccccatat aggaaagggc tgtatacata 2421061 actgctaaga gtacagctgc aatcgcggct gcttttgcac aaacaactat cagctgtttt 2421121 ttggtagaag ctccttgttc tttcaatgca ttcacgatga taattccaaa aacaaatgct 2421181 acaagggcat ccagagtgag gtatccttcc tgaaatcctt taaaaaacgc ttgtgatgtg 2421241 tacccttttg atggtgcttg aatggttcca attgggcgaa taagagctac ggctacaagc 2421301 aatccgataa atgtcagctt aattggcgtc aaaaatttac caactatatc aatgattttt 2421361 gaaggattga gtgataacaa gcatgccaat gcgaaaaata atattgtaaa tatgatcaat 2421421 gagacagggc ttgcatcatt tgataaaaaa ggttttaccc caatttcaaa cgatacgttt 2421481 cctgatctcg ggatagcgaa aaaaggcccg attgccaaat agagaatcgt cgtaaataca 2421541 atgccaaaca ccgggtgaac acggctggct aacgactgta agttttgttt acccgaaaaa 2421601 acaaatgctg ttatagccag taatggcaat ccaactccgg tcactaagaa acctgcatta 2421661 gcgacccata catttttccc ggccaattga ccaagcatag gcggaaaaat gagatttcct 2421721 gctccaaaaa acaatgcaaa tagcattaat cctataatga tgatatagga agcagacact 2421781 ttttttgaca ttatatatcc tccgattaaa gtagacactt cttgaatagc caggaaacat 2421841 tacagatgct atttgcactg gcacagtgtt gattccaaaa taagcttgtg tcagttttat 2421901 atatttttat caagttaaat aaaagcatga tcattttgat cgtttccgat atcggttaaa 2421961 aaaccaattg caccaaaacc atataaacaa cggttccccc cgctatggaa agaagcatat 2422021 ttttcttcca caagtgaagc agtacaacag cagctgctcc aaccaattca ggaatgccat 2422081 gacttccaga aagtagactc acatctttca aacaataaat gactaaaagc ccgattaccg 2422141 ctgatggcag cactttacca agatactgta catatttcgg tgtcggtttg ccagacggga 2422201 aaatcatgaa tggaaggaac cgtgtcagca ttgttccaag cacgaccatt gcgatggtga 2422261 tcatttgctg cgtcatagtc atcgtcatac ggaaacctca gctttctcca atggttttct 2422321 cagaacagtc agtaccccta aaatggcgag catagcagga ataataaatt ggtttccgcc 2422381 aaaaaggata agactggcta ctgaaagtcc aagtcccgtg agagcactgt aatgcttttt 2422441 ctctttcatc cattgttcta tgaatatcac aataaacaga gcagtcatca caaaatcaag 2422501 cccttcggta ttaaacttca cgtacgaccc aaaaatacct cctatcgctg cccccgcgac 2422561 ccaatataaa tgattaagca gtgtcacaaa aaacataaac cagcccttat caacattcgc 2422621 cggaacatta gcggtataat tgatagaaaa tgattcatcg cacattccga aaatcagata 2422681 aagctttttc tttccagtcc ccctgtactt atccaacatg gaaattccat aaaacaaatg 2422741 ccgggcattg accattaacg tcaaaaaaag agcattcata gggttgaacg caccaagtaa 2422801 aaaattcgct gcaacaaact ccattgagcc cgcaaatatc ataaaactca tgatgattgg 2422861 atagattgcg ctaaatccca aagaatgcat aaagatccca taagctatcc ccaaaaataa 2422921 aaaccccgca aaaatcggaa tggtatatgg gaatgcagaa cgaaatgcag cccatatttg 2422981 acttctctta ttcatatgag tgtttatagc aggagagctt aaatgtaacg attctttatt 2423041 tttattcaaa tcaacaacct cctacatttc atcaattggc acactgacag ttcttttttc 2423101 tgtactcatg actatgcttg tgtcaactcc actaatagca gggttctgca ttaatgaatc 2423161 aatgataaaa ttccgataac tctccatgtc cttcgccaca atcttaagca tatagtcatg 2423221 gcttcctgta agtgtgtagc attcttgaac ctgtgggaat ttgtttatat cctctaaaaa 2423281 tgaatgaatt gtctccctat ttaagggtga taagttgatg agagctagtg ctgtgacttc 2423341 gattccaagt tttttctcat caacaatagt cgtaaacttt ttaattatac ctgcttctac 2423401 taggttcttt gttcttgcaa ggcaagctga tggtgaaagc ccaattttct tagataaatt 2423461 taaatttgat attgaagcat cttcctgcaa atctcttaag atggccttat cagtttcgtc 2423521 aagcataata cccatttcac aacccccaat acaacttaac agaattatat ttcatacaat 2423581 ttaaataata acgaattttt attcgttaat caaatattat ttaaatttaa atccttttaa 2423641 agtattattc acagaataaa attatcctcg cgattaactc ataatgaaat taacttacat 2423701 cagaaagaag tcatgggaga gttatgtact tgtgtgactt gataccaaca tcataagaaa 2423761 cttatcagaa gccaaaaagt tattgcggtc tcaccgaaaa ttgaatttgc ggtgccctat 2423821 tgcctttttc cgcgaacgaa aattgttaaa attcgcaaaa cagaaagtct actctattat 2423881 tattttaaat tcgtccttta gttcttcttg agcctcttgt ataacttcta atacatcgtc 2423941 agcgtatgaa cctaaaaatg tattgctgaa ctcaaaattt ttcaagacta aagtgagcgg 2424001 caaatccacc caccctgtca ggcaatccca taaagcgtct aaatttctcc catagtagtc 2424061 tgggaagtct agtttatctt ttaaatcatc atgtaaaact tctatatttt caaagtctct 2424121 tccatctatt attatttttc tcattagaaa ctatgccctc cattatttta tcttaacaaa 2424181 cgtttactat gtaacagctg tttgtccaaa tgaggctgaa aacaaataaa aaacaccgat 2424241 aggatgaaac tattggtgtt tgcaagacat cttcataccc ggtaggcata aataatgcta 2424301 aactttgttt ttaaaaagct atcatatcaa atttttatgt tacagctttt actatcgttt 2424361 aatctaattg aggagtaaaa caagatatgt ttgaaaatca catatcccct aaaaattaaa 2424421 aactaatcgg cagttcttcg agtgctctca tcagaaaatt ccctttccat ttcatttgtt 2424481 tcttttcgcc ttttaactgt atatttggac agcggcgtaa taaggtggaa atcgcaatct 2424541 ttgcttctaa gcgggctagc tgtgcaccaa gacaaaaatg attgccatgg ccaaaagcaa 2424601 tatggcggtt gttctttctt tcaatatcaa atatgtcggc atttggaaat atcttttcat 2424661 cacggtttgc tgatgctaaa gaaatgatga tcacatcttt ccgtttaatc tcctgcccat 2424721 gcagtataaa cggttcagcc gtccagcgaa ttgtcgttag ctcaacaggg ctgtgaaacc 2424781 gcaatgcttc ttctatggct gaattcatca agtccggctg ctggcggagc ttttctagtt 2424841 gatcatggtg acacatcaga gcatatgtca tattggtgat taagtttacg gttgtttcat 2424901 gacctgcaac gataagcagc ataatcatcg agtacaattc ttctgtactt aattgtgtgc 2424961 cttcactttc cgcttgaatt aatgcactga ttaaatctcc tgcaggttct ctcctttttt 2425021 tgcgaactaa ggattccaga tattcaacaa actcccctaa caagtggtca ttctcctgaa 2425081 gtctttcagg ggcatctgaa aaatcaataa ttgcttgcga ccatactctg aatttttgac 2425141 gatcttccaa gggaatgccg agcatttcac ttatcacgat aatcggcaat ggaaacgcat 2425201 aatcgtctac taggttcatg aatttgttgg gctgcacttt atccaataaa gaatctgcga 2425261 tatgctggat tttgtcttcc aactgcaaaa tcatccgatg cgtaaatgct ttttgaacaa 2425321 gagttcgcaa gcggttgtga tcagggggat ctgaattaag catatgtttt gttaaagtct 2425381 cttcattctt caatagagca ggacgttttt cttttgcggt aaatacattt tcatagtttt 2425441 tctttaattt ttcattcttt aataaatgta ttgcatcatc atatctcgat atgagccagc 2425501 ctttccccag agctcctaaa gataatgggt agagagcctg tgattttcgc aattctttat 2425561 aaaattcata cgcttcatct ttaaatgctc tcgaagacaa ttgactttcc gtcaaaatgg 2425621 ttacactctt tttttctttt gaagacattc attcgacctc catctttgaa aggttatgat 2425681 aatctttaaa tataaaatca ggacgatttg taaaatgatc cattgagatc agtattcatg 2425741 ataagggcca aaatgccgtc cccgcatttt gaaataaaag atatgagaca gtcattaatc 2425801 attttgctgc ctaaactctt tccctgataa aatggcgaaa ctcctaatac ttctatgccg 2425861 gctcttttaa ggatttggaa aattttttag ccccattttg attaatgtta tcccccctgc 2425921 tgctatataa tcgatcaagt ttaatgtcgg gtttatcacg atgttttaat agagcggcaa 2425981 caaccatttc accattctga atgccaacaa aaaagaaatg ctttttaaaa tatgctcttg 2426041 tcagtacttt atgcatttca aaaataaatg aatgatcttt ttttcgcgtt ttacgagtaa 2426101 atccataaaa ggatattgat tgaaagattg atggaatagc tttgccactt tgcttacttc 2426161 atctgctctt gcttgtcgat aaagaaacat tgatgcacct cctctgagca gtaaagcagg 2426221 aaatcgaatt aaagcgccct tcctattgga aaggcgcctg ccgttttact gtgccaaaat 2426281 gtttttcatc agtgagtttt tataaaatca tttattaatt gatcagttgt caatattgtg 2426341 gcaaattcat catgcaatgt agctagagat atattatgaa tagtcgccgc atcataatat 2426401 gtatcatttt ggtctctcat tccgaaggct gctgttgcat ctgaaatcag gtatgtatca 2426461 aaccctaaat taccactcat tcttgtggtg gttgatacac agtgaggcgt ggttaaacca 2426521 gttatgacta cagtggttat ttcatttaat tttaagaatt cttctaaatt cgtaccaata 2426581 aagctgctat ttactgtctt ggttataatg acttcttcat ccataggctt aactatttcc 2426641 tttattgcaa acccttcatt ctttggatgg aataaagaat gaggtttatc agaagtgtgt 2426701 tgtatgtata tgactgtcca tcctttttct ctccataatt ctagtatttt actaatgttt 2426761 tcttccgcct ttacgttatt ccgttccccc cattttttat catcgaaggc tttttgtaca 2426821 tccacaatga ttaaagcttt cttttcttcc acaagatacc ctcctacgta gaatttctat 2426881 ttattactac attctaaata caaattttac ttttgtacaa ttgtttaatg atgaatttca 2426941 aatgagcgcc ttctttattg gaaaatgcgt tctatactgc aactgtgccc aagccgttaa 2427001 ccttcaaatc taatctgaga atcactggct ctacagagaa taataaaaaa cactctaata 2427061 acgagtgctg aaatgaaaaa ctattgattt agaagccatt tgatacgctc agctgaaatg 2427121 atgtagtgga gtattataag acataaaaag acaatactaa ctggttttaa ataactaaaa 2427181 taaagcgctg caacagccat tgcaaagatc aataattcaa taactaacct tgttactccg 2427241 tttacagcta ttacagtttg tccgcttcga ctaggatcat gaggtactgc aaatacagac 2427301 cagacaatca taactgcaat aggtaaaacc aaagttaaaa catatttaaa ataaccatta 2427361 aagcttatcc aagcatacac ccctaaggag attagtgcag caatttcaag ggtgaatctt 2427421 aaaagtaaat tagtctgatt cagtttttcc aactcctcta taaaaaacac ccccgcagga 2427481 gatgctcttt ctctgcttta tttcagcgta taaaaacttt tctgttcttc ctctttagat 2427541 tctattgtag ttttcggcga gattacctct acttttgaag agatgatacc gactgctgct 2427601 gttaccaatg ctccgataat agaacgatga taagtataat gaaatatgac aacttttccc 2427661 ctcctattca gttaattatc caaataatca ggaagttgtc tacaatttgc agaatttgtc 2427721 gaacgaagta aagattatac ctgggaggct ttactcattg tatgaattac agtaaataaa 2427781 ttgccttccc ttttgagaag acgttccaac tcagctagac tcttccaata ggcttccttt 2427841 tggcgcagct gcttttattc aaaaattgag caacacctga atgtttcatt ggaatttctg 2427901 aaccatcgat cgctgctgaa tttgttgcaa atgcatacgt aggagtagtc gaatggtggt 2427961 tgaaaaatga aatgccttcc ccacctcgag tgatggcaga aaaagcgggg gttttgttag 2428021 agaggaatct atagatatgt gtatcgaaga tttgacagca ttaaaaatta tacttacatc 2428081 gttgggaaca ggccaacaat aaagcggaag aacgttgtca tttgaagtgg tttggaataa 2428141 aaatgattcg aatatgttct tatcattgta aacgaacaaa aaaagaacat gttttgaaaa 2428201 aagattgatc aaaacatctt cttatatgtt gtcatagcgt aactttttat aaaaaggtta 2428261 attacatttt cggggcttcc aaaccaaatt ttgcccattc ttcttttgct ggaccataaa 2428321 tacctggaac agttaaacct gcttgtctca taagaacagt catttgtccc cgatggtggt 2428381 tttgatgttg aattaaaaac atcaaaagtg aaccgttagg catttgttgt ccaataaagt 2428441 tgatacgttc ttgaagtgta tggtcagtcc attgggtttt taatgcctgt acaaatgcat 2428501 tactggcttg atgatagctg tcagctataa actgagcaga agttggaaca ggataatctt 2428561 cagctggggc ttggaacgtt aagtctgtgt ttgaggtaat gatgccaatg gcagcaacag 2428621 tatgccaagc aatacggcct agagtccaat tttgtgaagt tatttcttgt ttaagtgatt 2428681 catcagtcag actatttaat agtttctgtg tagcatctgc ttcgaactcc caagatttca 2428741 aaaaatggtc taaggtttga aacacaaaaa tcctcctttt cattcttttg ttttttcaat 2428801 gtgcttatag gttaattata atgcctcctt tcgttaaaaa gaacaaaaat ttcggacaag 2428861 aataatcata gtaaaatgcg tagacattct taaacgtaac gatttacgca tctttttaca 2428921 aacatctgac tacttggtct ccattgtcag cgagaatcaa atatcatatg aagacaatcc 2428981 tatattctta tcactttact gagcaataaa taccttccgt atacttagta ataccttcat 2429041 cgtaatcagg atacttatat gcaagacctt ctgatacagc ttttgaatac tttctaaata 2429101 atgcatagca agtaaataaa gacttccaca tttcctgata cccattcaca gaatatgtag 2429161 acatgagttc ctcccattct ttatttgaaa ggtaccgctt cataaattta tagttcttcc 2429221 ccatactaaa tgaataccct ttctgagatg cgatatgcca ggccatcatt ctcaataaat 2429281 taggacgtac aatttcattt aaatggtcaa tggcaaaaag gatttcattt cttgctagtc 2429341 cttttactac gtaagtcgaa accatccaga actcattaca gcaatcatca aattcccttg 2429401 cagtcggcct ttttatccag tattggcgat catttggggt cactttatag ttgatgaacg 2429461 aatccttatc aagcaatacc ttaaccaaac catcgttatt agcaaaataa tcttctgctt 2429521 cacgaattgg aataagggtt agatctaatt tgttgccatc ctcaaaaaga ataatgtatg 2429581 aaaaccaatt acctaattcg ggaggaaaaa gctccatatc ttctggtttt tgcatcataa 2429641 tgcgcttccc aaagatttcg agccactgat cattttcttt aaaagattct acatcagtta 2429701 caaaatacga gatgtcataa tcttggaagt tgtcaggagg gatatttctg tttgtacgtg 2429761 acccttccaa agtgaccaat cggattctct catcgttcaa agcaaagtcc aaaaaaatgt 2429821 ccatcatttc ctgctcactt cgcattacat gttcctccgt ttcagcctta atatctaact 2429881 gtaaaacgtc ttatagattt ttttactctt gaatgtgatg tattcttcta agctttattt 2429941 tacatgatgt tctcctatat atcattcaat attaagatgc aagacatctc aaaatcagat 2430001 atcaactatg acggactaca tgaatattca gttttttgta gagccgccat gggacgacac 2430061 tatctttgac acactttaat cccccctgct ttatcgacat gttaactggt atgagagatt 2430121 gacaaaaaga aggaaaacga tatatttaag cgaatacgag tttttgagta aattttaaaa 2430181 tgacactttt ttcaaaaatc atgtcttaac gggaggattc ggtatgaatg aatttatgaa 2430241 aaagttttct ttaacaaaac cgattattca agctccaatg gctggcggta ttacaaagcc 2430301 ccgacttgca tctgcagttt cgaatcaagg tgctcttggc agcttagcat cggggtatct 2430361 tacgccagac ctcctagaac aacaaataaa agaaatattt gagctgacag acgctccttt 2430421 tcaaattaat gtgtttgttc cgctaggtct agagatgcca ccaaaagatc agattaaaaa 2430481 gtggaaagaa aacataccgt tagctaatca agtaaatcaa ttcacatctg tacaagaaga 2430541 gtgggatgac ttctatcaaa aaattgatct aattttaaaa tacaaggtta aggcttgctc 2430601 attcactttt gatctgccgc ctgaagacgc agtaaaggag ctaaaaaccg ctggatgctg 2430661 tttaatagga accgcttcaa cagtagaaga agcattgtta atggaagaac ggggaatgga 2430721 tatagtagtc cttcaaggaa gtgaagccgg tggacatcgc ggagcattct taccttccaa 2430781 aggtgaatct gccgtaggtt taatggctct gattccacaa gcagcagatg cactgagcgt 2430841 acctgtcata gctgctgggg gaatgataga ccacagagga gtaaaagcag ctttaaccct 2430901 cggagcccaa ggcgttcaaa tcggttctgc ctttttaatt tgtcacgaga gtaacgcaca 2430961 tccagtgcat aaacagaaaa tactagaagc aaacgaagca gatacaaagc ttacgacatt 2431021 attttcaggt aaagaggcca gaggaatcgt aaataaatgg atggaagaaa atgaacagtt 2431081 tgagacacaa acccttccgt acccttatca aaatacacta acgaaggcaa tgagacagaa 2431141 ggcttcactt caaaataacc atgatcagat gtctttatgg gcaggtcaag ggatacggtc 2431201 attgactgag gaaatttcgg ttaagcagct tttaaatcag ctttgccaag aggatataaa 2431261 aatataggcg cacctcattg atagagcaaa aagcaaactt tgacaggcag tttgcttttt 2431321 ttttcgtaat ttcatccact gactctggaa atctaaatac tcctacattt tcaaagctaa 2431381 tttgaatcgg gttatcaatc atcacattga tacgatgcga tcttgataat ttcaccacaa 2431441 ccacaataca ttaccaacat ttcgatctta tctccccttc tcaagttttg ctccctattc 2431501 gaataatcga tagctcccat attaaatttg aatagtaaaa tggttctttt tcgtttgatt 2431561 cagatgatat aaagtcatat gataaaaaaa gaatgagaca gaaagcgtga gaagtgatga 2431621 aaataggatt ttttgattca ggaattggtg gcatgactgt attgtatgag gccataaaag 2431681 ttcttcctta tgaagattac attttttatg cagatacgtt aaacgttcca tacggtgaaa 2431741 aatcaaaggg taaagttaaa gaatatattt tcaatgcagc tgaatttctg gccagtcaaa 2431801 atatcaaagc tcttgttatt gcgtgtaata cagctactag cattgcgata gaggatcttc 2431861 ggagaaactt cgactttccg ataatcggaa tcgaacccgc tgtaaagcct gctataaata 2431921 aatgtacaga ggaaagaaaa agagttctgg tagttgctac taatttgacg cttaaagaag 2431981 agaaatttca taatctagtt aaagaaattg atcaccatga ccttgttgat tgcttagctc 2432041 ttccaggact agttgaattt gctgagaact ttgattttag tgaagacaaa atcattaaat 2432101 atctaaagaa cgaactatct tcttttgatc tgaaacaata tggaacgatt gtgttaggat 2432161 gcactcattt tccgtttttc aaaaacagtt ttgaaaaact gtttgggata aaagttgata 2432221 tgatttcagg cagtgtcggt actgcaaaac agttgaaaaa agttcttgca gatcgtaacc 2432281 agcttggtaa aggatcgggc tcaatcacct ttttcaattc tggccataaa attgtggacc 2432341 aagaagtcat atcaaagtac aaaagattgt ttgaaatatt agatgaaact caaaggagtc 2432401 atgttggaca ttgaatgtaa atgaaaaaga caatctcctg aagagaaaca tgaactaaga 2432461 agcgggctta aaaagcccac tttttttcta acaaacaatt gagttataca cacatatctg 2432521 attacagtgt tttctctctt tcccctctta tttctccccc ctctctatag cttttctatt 2432581 tcaataaaac acaagtctcg attgaaaagt tatcgtaaca tttacacttc acaggagatt 2432641 tttcacgatt gcgaatcgac cgtttgccag atgcacaaag tcataatgtg taaattctgt 2432701 atctatgtgc atgtttatta tggaattatt ttcataatgt tttataatac aagatgatag 2432761 cgttttctaa ttataatgat agggggaaat aatgatgatg aaaaaaggtc tgcttgcggg 2432821 tgcgcttacg gcaaccgtgc tttttggcac atgtgcagta gatgtaccgg gtattattag 2432881 tccaaaaacc gcagaagctg catcacagct aactgatgga atcggcggga gggcttactt 2432941 gaacagtaat ggtgccattc ttgttacgaa aatccagctt cctagctcca ctcaggtttc 2433001 aaatgggaca gcctacatct actctggttt tagcggaggc acagaatccg atatcgggtt 2433061 tcagtacagt gataaatata atgtatggaa accatatatg aaagtcggtt caaaaggaca 2433121 ggatcaggtt cagtacctcg aaggaggaag ccaattcacg aatacgaaag gcttccgtcc 2433181 cggcagcacc gtacaactta ccatctacaa aaaccttaac ggcaataccc gcgctacata 2433241 ctggggcacg aacaatgccg gatacaacgg ccgtctcatt tcagaaatca gcaaaacaaa 2433301 tgtcggctcc atctcaaaat ggaaagcgct cgctacagtt gcaacaacag ggtcacgcca 2433361 atctatcaaa tcaaactttt caacatcttt tacaaacatc accatcgaca acaaagcaat 2433421 aacacctgta attgatacac aagacttcgc taaagtaaca gtctcaggca acagtgtcag 2433481 tttatccgtt gtcaaaaatt aaaacatgtt aaacatacaa tgcgttaggc tattgagaag 2433541 ctctcgatag tcttaaaggg ggcttaacat gccccttttt tcatttcaat ttaactttca 2433601 gttagcttcg gtacatgccg tctatccccg tcttttatct gggtgaagta agggcagctc 2433661 gccccttctg aacctgttcc atttgctcaa cgcaaaaggt gtgcatcact gtcttaaaaa 2433721 tgttaaaaca aatagcagat ggtgcacttt atttttagat gaggcatgct tacgctcgat 2433781 atgcaagtca aatgattaag ggtctgcaag agagagaagt tttgggtgta ctttcataaa 2433841 agagggatgg cttcatatag ctcgattgca tcaggaagat tagccaacga ttggccgaga 2433901 acaacacatc actttgaaac ggattcattc caaaatcata agtatgatcc aataactaat 2433961 aaagatcagt tagcagtcca gccttaaaaa tatttttaca tcaattaaac tagcatcact 2434021 atcgaataag ctcgatctgc atatcatgta ctatcctctt ttaaggaagg tgatgttatg 2434081 aggtcatttc cattaatcgt agttctattc atcctattaa tcatcgttgg gacatctttc 2434141 tttggtggct attaagaaca caccttacct catatccatc agacgccata agaaatcttt 2434201 atggcgtctg ttttttatta gatttaaaca aaaccattaa agtgggccat gcaaacacac 2434261 ctatggagat tactgccacg acttctttgt gagggaatta ttcttccctt tatggactat 2434321 tgtcgatcaa aagagaaagt tgaaatgcat ttttatggtg agatgaatcg aggcttagac 2434381 atataaaaaa ccgcaaagct ttcttgaaga agctttgcgg tttttgggtc tcttctttgc 2434441 ttcatataag ccaatagatt tcaagcgtaa tccactgcca tacatccaat gattttttat 2434501 tttgaaatag gtttcttcta ctcttcatgt gagatgactc aaggtatgcc acgtcacaat 2434561 aatatggcgg atactgaatg gtctcaatca gttttttccc cattctatca attctccaca 2434621 gaaaaaatgg ctatggcaga acaactttca tagagtaatc atcatttaat gagccatcat 2434681 ctcatgggca atatcgtgtc catccatttt tgacgggtag taagtaggcc agtttttgac 2434741 ttcatcaagt aaagcttcac ggtcgtcccc ccaatagaga tggtaatgac tagctttagt 2434801 cgggtaaata ctatgatcac taaactgaat atactgaggc agcccttctg cttttttagc 2434861 tagtttgaat atgtatctta cccctctatt gcccgcatca taggttagaa tttcgtatcc 2434921 gtcatacgta tacttaccag aatattcttt tccatttttg aagaacgtta cagtatcttt 2434981 ctggattaca atacggtcaa catctgtttg atagcctttt ttataatact ctttatattc 2435041 ttcagctgtc ttgccgcctt cgtgttctga tttatatgaa aacacttcgt caagagtacc 2435101 atcttgcagg tatggatata cagattgcca atctccttcc caatcagaaa gtaagcgatc 2435161 ctttacttgg ctgtttttaa aatagccttc atatattttt tctgtttctt catcatgcgc 2435221 atgactatga tcgtgagaat gttcgtgtgt atgactgtca gatgtttgct cttgcgtttt 2435281 ggaagagtct tcttcaactg ctgaggatga tgttgtttga ttagactcac ctgcagaaga 2435341 accggaagtc tgacatcctg ccaaaactag taatgaacca atcgttaata tgcctagccg 2435401 ttttgaaaat aaaatgttca ttccaacact ccttttttat taaatcgaaa acattacgat 2435461 ttattataca tacatctctt gcaaacatca aaggaaaaat gctcttcatg cggatggcct 2435521 attttaaagg aataactgac tatgttcatc agttattcct ttaaaatacg aaagtctacg 2435581 atatttccat atcgatccgc ttcaatgtga cagcacccct caagcagctg ttttaatttt 2435641 ccacgtccgc gttgtaccct tgattttgct ccggagtaag aaatgccgag cttttcactc 2435701 aactcttttt gtgataaccc ctggaaatca gttaactcga gcgcctctcg atacttttca 2435761 ggcaaccgtt tgatggtcga tcgaatacac acagttgctt ccttggtgaa attttcttcc 2435821 tctgcactgt cattaaaatg tagaacatca ggcaatattt cgcttgtttt ttttgtacgg 2435881 taaaaatcaa taatcgtatt tctagtgatc cgataaatcc agctgtcgat cttttgttca 2435941 tcgatcagat ttgggagatg cacttgtatt ttcataaata cgatttgcaa gaggtcatca 2436001 acgatagatt gatcgttaac cctatgtgaa atatatgttt ttaacggctg atgaaattga 2436061 tcccatagat cctctatatt catttgaaaa aacctcctat aattttgcgt ctgctttaca 2436121 tttgcttcgt ctttttaatc gtaacaaaga gcaaacaatt gttgaatcaa ttgtattgca 2436181 gctgttgcca aaaataatga taaaggagag gtttgttgtg gagtatacct atttagggag 2436241 aacaggattg cgggtgagcc gtttatgttt aggcacgatg aattttggag ttgatacaga 2436301 cgaaaagact gcgttccgta tcatggatga agcacttgat aacggcattc aattttttga 2436361 tactgccaat atttacggct ggggcaaaaa cgcaggattg acagagagca tcattggaaa 2436421 atggtttgca caaggaggac agcgccgcga gaaagttgtt ctggcgacaa aagtatatga 2436481 accgatttct gatccgaatg acggaccaaa tgatatgagg ggcttgtctc tatacaaaat 2436541 cagacgtcat ctggaaggat cactgaagcg gcttcagaca gatcatatcg aattgtacca 2436601 aatgcatcat atcgataggc ggacaccgtg ggatgagata tgggaagctt ttgagactca 2436661 ggttcgctcc ggcaaagtag actatattgg atccagtaat tttgcaggct ggcatttagt 2436721 taaagcgcaa gctgaagctg aaaaacggcg attcatggga ctcgtcactg aacagcataa 2436781 gtatagttta ttagaacgaa cagctgaaat ggaagtgctg ccggctgcac gggatcttgg 2436841 tttaggagta gtggcgtgga gtccccttgc aggagggctt cttggcggga aggcattgaa 2436901 aagcaatgcc ggaactcgta cagcaaaaag agcagattta attgaaaaac atcgtttgca 2436961 actcgagaaa ttttcagatt tatgcaaaga actaggagaa aaagaagcaa atgtggcttt 2437021 ggcatgggtg ctggcaaatc cagttttaac tgcgccgatc atcggaccac gaacggttga 2437081 gcagctgcgt gatacgataa aagccgttga aatcagtctg gataaggaga ttctccgcat 2437141 gttaaatgat atctttcccg gacctggagg agagacacct gaggcatacg cctggtgata 2437201 cattcattac tcaatactga catttttctt aaatatttat actgaactat catattaaga 2437261 aagacaagag catgtttgtc tcttgtcttt tccacatcgt gctgaaaatg ctggctaaac 2437321 atcgacaaaa atgctgccgc ttaaaaaaga accctaaaca atagagtaac tggaaagaca 2437381 actggcttga tcagcttggg acccctttca gctgtattta aatcaatcaa actaatgatt 2437441 cattggcagt ctaaatatta ttattgtttc tttacaaaat agtaatagcc cctgtaatga 2437501 ttgctaacaa cgtaataact aatgatgtaa ttacagccca cttaacggca aacctttgaa 2437561 atgaccccaa gtccatttta agcatgctta ctagcaatac tgttgacgca accaatggac 2437621 tcatcagatg aaccggctgc cccattatag aagcccttgc aatttctact ggttctatac 2437681 catatgctga ggcagcttct gcaaagatag gtaccatacc aaagtaatat gcatcatttg 2437741 ataaaacaaa agtaaacgga atactagtga gtgctacaat aacggggaaa aaccctccca 2437801 ttgatgaggg gatgatggat attaatgatc ctgctatggc atccaccatc tttgtcccgg 2437861 ataatatacc agcaaatact cctgctgaaa ataccaataa taccacggtt atggcattac 2437921 cagaatgctc ggcgattcgc tccttctgca tttttacatt cggataattt atagtaaggg 2437981 caagaacaaa accaattaaa aataaaactg acggatgctt agttccaagc acaataaaca 2438041 ccatgatact tataacgagg aataaattaa gatatattaa gcgtggcctt ttcaattgtt 2438101 cgctctccaa agtagcagcc atataagatt gagagctgtc ctttgttata tgtctaggct 2438161 ctaattgaac gatgcctatt cgattcctct ctttccttcc cattagaaaa gccagaaata 2438221 tcacacaagc aatacctcca agcatggtcg gaagtaatgg cacaaagaaa tctgaaggat 2438281 ccaaacccag cactgaaatc gctcttgtag ctggtccgcc ccatggagtc attccgctaa 2438341 cgatactcaa cgacagcatt gctaatgtcg ccataaccat gggattcata ccaattcttt 2438401 tatacaaagg taacattgct gagactgtta tcatataggt tgttgtaccg tccccatcta 2438461 aagcgataag cattgccaag acggcagacc ctatcgctat tttcacaggg tctcccttta 2438521 ctatagataa aattttttct attagcggat caaataaacc tgcatcaatt aaaattccga 2438581 aaaaaagaat agcaaacaat agcaatgccg ctgaacttgc aactgtttga attccttcta 2438641 aaatcatgtc gccaataccc ttaccaaaac ctccaataag agcaaaaaca atgggagtga 2438701 tggtcaaggc aacaataggc gagactttct ttgtcattat taatattgta aaaacagtta 2438761 ccatcgaaaa acctaaaata gtaagcatat tacacctcca agaatgcgct ttcaaatgac 2438821 ttttgattaa catatcttat acggtgtaat aagttaaata aatatttttt tactgtgttt 2438881 caaaaaaaat tctatcataa ctttaaatgg ttaccatttg ttcacccttt aaaaaatcaa 2438941 tgaatgcttt aacgagtttg attcctaatg atttttgatc gtacattagc caagtatctc 2439001 tcattagagg cttaccctta gcattataca gttccattgt gtacaaatga tcagattcct 2439061 gcaggcaaat ttctggtgct atggagtaac caagaccatg ctttaccatc tctttgcaag 2439121 tctcttgtcg atccacttcc attgcaataa tgggggcttg ttttagattc gtatgcatcc 2439181 aatcttctat aatcgttttt aaagaagcat ccgttttata tttgataaaa ggtaaaaaag 2439241 gaagttgctc tatcgttatt ggtttttttg agatgatatg taatttttcc cgtgtcagcc 2439301 gttcctccac ccctttccag cgatggcttc ctctcagtat accgacttgt acaataccag 2439361 catctaataa tttcatgaca tctgtgctcc agcctgtttg tacactatat tggacattag 2439421 gatacatagt ggaaaattcc cttaataact tagggagctt atattgagcg aaattgcttg 2439481 atacccccag ccttagatgt ccttgcacct ctttgcttag attagagata tgatctttgg 2439541 tatcttgaag ttcctgtagc attcttcttg cataagcaac caagtgttct ccttccgcag 2439601 taaaggtaat tcctttatgc cttttggtga ataattcaat tccgaaaatc tcctcaatct 2439661 ttttcaaccg ataagtgatg gaaggctgtg atgtaaataa tcgttctgct gtttttgtta 2439721 cactttgttc ttcgtgaaga attttcaata aaatccaatc tttctcatcc attttcatct 2439781 tcctttctag tccttctttc acaattataa aagttttttt atcgaatatt aagaaaactt 2439841 atattttatt tttatttttt taccttctac actaaaaaac ataaaaaata ctacctttaa 2439901 gatgaggatg atgacgatgg tcaagacgaa tgtaacaatc atgagaggcg gaacaagcaa 2439961 aggcgttttt ttccacgaat cagccatgcc taacaataaa aacgaatggg agcccttttt 2440021 gcttgatgtc atgggaagtc ctgataaaag acaaatagat ggtttgggtg gcggtaattc 2440081 ccttactagt aaagtggcaa taataaagaa agcatatact tcggatattg atgttcacta 2440141 tactttcggt caagtcagca tttcggaaga aaaggtggac tttaagggga actgcggaaa 2440201 tatctccgct gctgttggtc catttgctat tgaagaagga cttgtaaaag cgaaagaacc 2440261 aatgactgcg gtaaggatcc tgaataccaa tacgaataaa atgatcattg cggaagtaga 2440321 agtggaagac ggtcaggtca aatatgacgg agatgttacg atatctggag tacctggatc 2440381 tggatctcca atctatttaa actttcatga tgccgctggt tcagttaccg gtcatttatt 2440441 gcctactgga aatagttcgg agtttttaga tacaagtcaa ggccaaatag aggtgtctat 2440501 tatcgactat gcaaatccat tagtttttgt ggaagcgagc agtatcggcc tggatggaac 2440561 ggaacttgca gaagaattta ctgatctaca gttggctcaa tttgaagaat taagatccat 2440621 tgcggcagag aaatgcggct ttgccagtcg attttcagct acaaagttat cgccggctgt 2440681 ccccaaactg gctatagtag caaaaccaga gaaatataaa gatagtacag gtgcttggca 2440741 ttcaagcgtt gagatggact tacacatcag gatgatgtcc atgcaaaagc cacatcaagc 2440801 actggctgtc actggagcga tatgtacaac aagagccctt tcagtggaag gtgcaatccc 2440861 tgcaagaata gcaaaaaacc actctacaaa ggttcggcta gctcattctt ctggtattat 2440921 tgaaacaatg gtggagccca ctggtataaa gatcgtccgt accgcacgac gtattatgga 2440981 cggaacagtt tatacgcatg gagactatca aatgatgtag atggactgtg caaaaagcct 2441041 cccccctttc catcgttaat agatggattg aatgcgcctt cttgcacaga tccattgtaa 2441101 tcttgcatgg ctttaaaaaa gcctctatat tgttttttat gaaatcgcca aggtcctttc 2441161 atgtatctgc ctcaagcatg acataatcat tatagagaaa attgaatact ttttactgca 2441221 aataaaaaga taccaacatc attggtatct tttagattga gttcatctgc agcggtttct 2441281 tttcctcact gcttatttga ttacaaaatt accgtactcg tttgaacgaa catgaatcgg 2441341 tccgtttaga ttatagttgt tctccttggc gatagagcga agcacgtcca cacgggcaac 2441401 tgattctctc cattcgtcac gggtgtcatg attggccgga ttcatcagat cgtcatagcg 2441461 tacgtccaag aatttattca accacttctt ctcgtctatt ccgtctttag gtgatccgcc 2441521 cgcttttttg ttcgtacgtt taatcaaggc ataaaaagag tcagggtcat caccatcgcc 2441581 atgctgaata accgtatcgt acatcacagc tcttgccaat gctgttttta gtccggcatt 2441641 atccgatcgt ttcatggcag gctgataata caaatggtca tttactttgt cttgagcggc 2441701 gcgaaattcc ttatcatttg caagcgactt ccaggcagaa gcgaatccct tgagattgct 2441761 tgtatcatcg ctttcttcct tggccagacg gcgcaattca ggcagatact ttttcagttt 2441821 gttattcgga actgcctttg tgtatacttc cactacttcc aatgcatccc cggtagccgt 2441881 tgtaaagcct gcccgtccgc atgtatagcc tcgcccgtca tccaatcgct ctacatatcc 2441941 atattggatc tccgttgtgc cgttttcaaa gatacttgtc agctgttccg cccggcgctt 2442001 ttgatcttta ttcagtcccg ccgcaaaaac cgtttcgctc atcatcaggg taaaaaacat 2442061 ggtgaaaaca agtaatgaga tcgctgcttt tttccaaaaa tctgcttttt gcatactgat 2442121 tttcatttca cttccccttt ctaaatattg taaatacaga ctcagtatac atgaagaaac 2442181 tgccctattg ttgaaaatac atcaatttgt caatattttg aatctaaagt aatatagctt 2442241 gaatcttact ctattcattg ccaatcagcc ttagcccctc tcactgggaa ggtcccttga 2442301 ttttcatact gcttcaactt tcattaacaa gatgccataa ggctttactc tattttataa 2442361 tggaagtgat catcgaaaat cgttagggag gtgatgtaat ggcaagcaag atgagaatgc 2442421 cagattccgc aacgtcccat gcaaagccta ctattgggaa ggcgatactt tgcatggggt 2442481 agactttcta aaagatcgcc caagtaagct tttctgatat agtggctttg caccttattt 2442541 gacataaaaa aataaggagc tggcagaaat ggcatatgta aaagcaaccg ctattttacc 2442601 tgaaaagctg atatcggaaa ttcaaaagta tgttcaagga aaaacaatat atatccctaa 2442661 acctgaatcc tctcatcaaa aatggggtgc gtgttcagga acaagaaagc tgatcgatga 2442721 cagaaacgct tctattaaaa aagcatttaa aaacggcaaa accattcatc aattatctga 2442781 tgaatatcac ctctctattg aaacaataaa aaaaattgtc tactctaaat aaacaaaacg 2442841 gaagcactga taaaaaataa tcagtgcttt ttatatggcg agtttgtttc ttagttattt 2442901 cctgcatatg ataccattgg ccaattgtgt aaagttaagg gagatgagaa gaaaggaagg 2442961 tcctacaaat gacgataaac aatggaacgt tgcaagtacc cggcgcgaac atccactatc 2443021 aggtgcgtgg ctctggtcca atcattcttt tggtccacgg aggaggcggt gatgccgaca 2443081 agttccatca tgttgccaat catctggcta actggtacac ggttgttact tatgatcgcc 2443141 gcggccattc ccgcagcaat ctcgccaatc agattgaggg ttaccgtgtg gaaacacaca 2443201 gtgacgatgc tcaccgtctt ctagccaaaa tcaccaataa gccggcctat gtatttggaa 2443261 gcagctccgg ggctgttatc gggcttgatc tgtgcatacg ccatcccgaa caagtacatg 2443321 tcatgatccc acacgaacca atcttattgc agcttctgca tggaaatgag ctgaaacaag 2443381 ccgagcaatt catggaagac cttaagaaaa atcatcgaag tgaagtcatt aaattaatgt 2443441 caagattaga gacagacgaa caatcaaagg ctgtcctgac aaagcggctt ctcggcaatt 2443501 caacgtattt cactgagtat gaaattcaag gaattctcag ctatacatta gatttcgaag 2443561 cattaaaaac tgtgtttaca tcttcaccga tgaagatact cccagctggc ggaagtgctt 2443621 ctcgggagct ttttccttat cgttgcgcga acgccctagc ggaacaattg gaaacagaat 2443681 gggttgaatt ccccggaaat catacggggt acacaatgta ccataaagaa ttttctgaga 2443741 ggttacacga catgttagaa aaagaaaaga aacatacgtg ttaaggattg attaaaattt 2443801 tcaaaatagg acaggtgaaa ctaactatgg aattggagaa gatttcacga agcgtaaaaa 2443861 gaacttttca ctaacgagaa cgcaatgtga gatgtttaac caaagtgata ttagggattt 2443921 catcgaaaaa taggtttgta cattacgttc tcctattgat tatttcctat cttaattccg 2443981 tattttatac cattagatac aactctaaag cggctcgtta ttttgtcctc aacaacaacc 2444041 agtgtctaac atcatgaatc tcttttgaaa atcaccacaa atgcaggtat ggaagacttc 2444101 atcgcagcaa aaaccatacc aactattgtt gttggtatgg ttcgtcctag ataggccctt 2444161 aagaagagat tctattgtac ggagtattta gctaattgca tttgtaaccg acagggccgt 2444221 ctgaacctgt gtacacatat gtgtcagaca catatccaat attcacgaca ccccgggaat 2444281 ctttccactg gatttggtcc cagatattac tcgttccata cttccctgta acagtcgttc 2444341 cataagcgta acaataataa ggaacacggg agccactcgg aatggaaagc ataataggat 2444401 aatttgtacc aggaccgctg cgcatattga caggcgcacc gctgcttgtt gagacagtaa 2444461 agtactgaac ggcaagtgcc tgactggaaa aaatgaataa agatgcaatc atcacggtta 2444521 acatactcag cattttcagt ttagtcaatg tcatccctct ttcttcaatt ccttcatttt 2444581 aagaaacgat agaacatagg ctaccagctg catttaggaa caaccggacc gtctgagcct 2444641 gtatacatat atgtatcaga gacaaatcca ggaacgatct ccccgctggc aagcgtccgc 2444701 tctgtgtaat tccaaatatt gctcgttcca tactttccag ttacagttgt accggttttg 2444761 tagcaataga tcgggatgcg ggttccgctc ggaatggtcg ttacaattcc ccaacttgta 2444821 cctgggccgc tgcgcatgtt gacaggagca ccgctgcttg ttgaaaccgt ataatactga 2444881 gccgcaagtg catggctaga aaaaatgaac acagatgcaa tcatcaccgt tagcatactt 2444941 agcctcttta acttattcac cttataccct ccccttataa atgccgtacg tttgactttc 2445001 ttacatccag ttaaggattt actttcagat accatgcccc ctcccctccc atatatttat 2445061 caatgtacca taaactagat ctttcaaaag tggaattatt cctatgtttt cgacaattaa 2445121 ggatacaaaa taaatggtag tcaggcttga tattgatggt gtgttacatt tggctcttaa 2445181 tcatttgtcc agtcggtaat cacgattgac aatcaggaaa aaggacatgg atcaagcggc 2445241 ttcgtttcca ccaattaact caatcagtgt actgcttcct tgtatccacg cttcttctcg 2445301 attcatagat actccacctt tttcaccaat caaaaacgga caccatacaa atcagcgtaa 2445361 atgctgcaag ttcagtgtcc gcaacctatt atgactttgc tttcttttac cagggcgtgt 2445421 aaaaatgatt aggtacgtta tcaaacgtta ttctatgatt ttgcgagtca aaaaatcata 2445481 acattttata tatttcaatc agattatgat ctggatctct gaagtgagca actcgggcac 2445541 tccattcctt gcgatcatgc ggtttattct cacatttaac tcctttttcg tgtaaatcgt 2445601 catacgtttt atcaacatct tctaccttaa actgaagcaa aaattttgat tgagcttctc 2445661 cttccaagga ctttttttcc tctccaacga tttcagccat cgtttctcga gataaaagct 2445721 ctattttcgt ttccccatta tcaaagagtg catattccat ttcattctct aaccaactta 2445781 ttggaagtcc taatgaatct ttataaaact cgacgctttt cttaaaatca ttcaccaaca 2445841 gtctaatttg taacagcttc atatcgagtg cctcctataa aaccatactt ttactggtca 2445901 tccaatttaa tgataccaaa gaaacctgac agcactatgt caagtttcca tacttcaccc 2445961 ttatttcaga tttaagtgca gtttagtcca tgtcataaga acgagcaaaa acagcgattc 2446021 ttaaaacaaa aaatgatacc gagtgtattt tctgtatgct tcaacttcat ttcgggaaat 2446081 gtaacgttga taaaaggagg ttacatcaat atggatcatc aaacattggc agctcatgag 2446141 gctgttgact tacatgaaat cgtgaacttt aaaacacttt gtatagcgaa atcaaagtta 2446201 atgcaagggc ttgtgtttga ccaagaactg aaggacttga tggaaaaaga tgtacagcaa 2446261 tccattcaag accttactga attacaagcg gtttatgagc gtgcctcatt tcaggcccct 2446321 gtccctcaaa gccgcccaac gccaatcatc aattgaaagg gaggtaagcc tctttgaata 2446381 atgatcattt agaccccatt aattcgctga atgtgcctga actagcagac actacattcg 2446441 cgatggattt tcttatacga gctaaggaag gcgtaaggaa tactgctgta gctttgacag 2446501 aaaccgcttc accagatgta agagcactgc ttcggaaaca gctgatgcaa ggaattgcga 2446561 tgcaccaaga gattacggaa ctgatgatca gcaaaaagtg gttccatcca tatgagctga 2446621 gcgaacagta taagctggat cagctctctg caaaaaacac gatcatggtc ggcaatatga 2446681 acctctttcc tgatgaaaca aatcgcaaag ggatgtttga ccggacacct gatgaacact 2446741 aacactggag gttttacagc atgaaggcag taacgtatca aggcattaaa aatgttgttg 2446801 tcaaagatgt ccccgatcca aagattgaaa aatccgatga catgattatc aaagtcacca 2446861 gtacagccat ttgcggatca gatttacatt taatccatgg attcattccg aatatgcaag 2446921 aagactatgt catcggccat gaaccgatgg gaatcgtcga agaagttggt tctggggtga 2446981 ctaaactaaa aaagggagat cgggtaatta ttccctttaa tatagcatgc ggggaatgct 2447041 ttttttgtaa aaaccagctg gaaagccaat gtgatcagtc taatgacaat ggggaaatgg 2447101 gtgcttattt cggctattca gggcaaactg gcggttatcc aggcgggcaa gctgaatatt 2447161 taagagtgcc gtttgcgaat tttacccatt ttaaaatccc tgaatcttgt gaggaacccg 2447221 atgagaaatt aagcgtgatt gccgatgcca tgaccaccgg cttttggagt gtggataatg 2447281 ccggcgtaaa aaaaggcgat acagttatcg ttctcggctg cggaccagtc ggcctgtttg 2447341 ctcaaaagtt ttgttggcta aaaggcgcaa aacgcgtcat agcagttgac tatgtaaact 2447401 atcgcttaca gcatgcgaaa cgtacaaaca aagtagaaat cgttaatttt gaagaccatg 2447461 agaatacagg gaattattta aaggaaatca cgaaaggcgg agcggatgta gtcattgacg 2447521 ctgttgggat ggatggtaaa atgagcgatc tcgagttcct tgccagcggc ttaaagcttc 2447581 atggcggaac gatgagtgca ttggtcattg cttcccaagc tgttcgcaaa ggaggaacca 2447641 tacaaattac aggtgtgtat ggaggcagat ataacggttt tccgttagga gatattatgc 2447701 agcgaaacgt caatatacgc tctggacagg ctccagtgat ccactatatg ccgtacatgt 2447761 ttgaactagt atcgacaggc aaaattgatc cgggagatgt tgtcagccat gtcctgccgc 2447821 ttagtgaagc caagcatggc tatgacattt ttgattcaaa aatggatgat tgtatcaaag 2447881 ttgtgttaaa gccttaaaaa acggaggtta cagaaatgga atacgcctta cacgaagtgc 2447941 ttgaggttca ggaaatgact gcatttaaga cactttgttt gacgaaatct aaaacaatga 2448001 aagcactggt atctgatccg aagctgaaag aaatcatgca gcaagatgtt gatatcacca 2448061 cacgccagtt gcaggaattt gcctctattt tatctaatgc aaagcaagaa tgaggagatg 2448121 aataaatcat gaatcctatc atagaatatc tgactggcat gaatgttcta acagaccaaa 2448181 tcattgctat ggacttatta atttcagcaa agaacggagt cagaaattat gcgatggcag 2448241 ccactgaagc cggaacgcct gaagtaaaag aggtccttat ccgccatttg gaagaagcac 2448301 tcgatatgca cgaacaactc tcaagctata tgatggaaaa aggctggtac catccttgga 2448361 accctgacga acaagtcaag ctgaatttaa aaaatattga tacagccatt caattgccaa 2448421 ccctttaaca tacaatgact gatttgctga ggaacagtat tgattggcca caactgttcc 2448481 tcagcttcaa aatgagcact gtttgttcgg gtcctatgac cgtaaataga ttaaccgctt 2448541 ttctccatct gatctccgat aatgtttgca aattctccaa tccaaataag gaatcgtaac 2448601 cacctctttt tatgcgatct cttgatggag aaaacaggcc agaaacaaaa tccttcgttt 2448661 ttgacctgcc ctcttcacac gcaaagaatg ctaccttctt tgctccactg atccgtgaag 2448721 actttccgtt ttaggcctgc ttttgagctt tgcctcattt tcacgcaatt tcccatcata 2448781 atctttaatt tttgtgtcta atctcttaat tgtttcatca atttctttcc gcttctctat 2448841 cagccgctgt cgttcgtcag ccaggatatt ttttcgagct tctaccgtac ggtcaccttc 2448901 ggtaaataat gttgtatatt caattagcgc ttctatcgat agtcccgcat ttcgcatgca 2448961 tttaatgaat tcaatccatt tgatatcttc ttcatcatag tcgcgaatgc cgctgtcttt 2449021 tcgttttaca ggcgggatta atcctacacg ttcgtaatat cggagtgttg cggctgtcag 2449081 gccaaactgc tttgccacct gagcaatatt catgatcttc acctctctat cctgtatgtt 2449141 gtgaaggtaa cacttaaagt taactttaag tcaagctcaa aacaagtggt tagctgctga 2449201 atctgggttt atatattcgg gacttgcctt aaagcacact ttaaactcta tacttctcca 2449261 tgcactaaaa acagtgtagt tggagggatt gctgaatggc aaataaacac actgccggaa 2449321 gagaacaatt aggagaattt gcgccaaagt ttgctgaact tcatgatgat gttctattcg 2449381 gtgacatttg ggcaagagaa gaagaacttt catcccggga tcgcagcatg attacagttt 2449441 ctgcattaat tactgactgt ttctcagctt ataaatcagg ttcattttaa atggtttttt 2449501 taaaaaaccc ttgccttaaa gcagacttta aggtttatcg ttatgttgaa gacaccataa 2449561 aacataaata agtgcatgtt tttatttaca acacttatga tgaagaaagg ataggttcgt 2449621 atgtgtaatc aacatcaaac ccgtgtatta agcgtgtcac atgcaaaagc caaatttgaa 2449681 caaacgacga ttgagcgaag aggattacgg ccgcacgatg tcttaatcga tattaaattc 2449741 agcggcattt gccattcaga cattcatagc gcttttgatg aatggggcgg tggcatcttc 2449801 ccaatggtgc ctggacatga aatagccggt gttgtaacag ccgttggaac aaaagtcacc 2449861 aagttggctg tcggggaccg cgttggtgtc ggctgttttg ttgactcttg cggagaatgc 2449921 gaatactgtc tcaacgcaga ggaacaattc tgcacgaagg gtgttgttca aacgtataac 2449981 tcagtagact acgacggaaa ccccacttat ggcgggtaca gccaaaaaat cgttgtcact 2450041 gacagatttg ttgttcgcat accagatcgt ttggaaatgg atgttgccag tccgctgttg 2450101 tgtgcaggta tcacaacgta ttccccgctg aaacactgga atgttggccc tggtaaaaag 2450161 gttgcgattg taggcgtagg tggccttgga catttggcaa ttcaatttgc acatgcgatg 2450221 ggtgcagaag taaccgtcct gagccgttcc atgaataaga aagaggaagc tctggaactc 2450281 ggtgcaaatc attactttgc aacaagtgac ccagccacat tcactgcatt ggccgggcgt 2450341 tttgacgtga tcttaaatac ggtatcggca aatctcgatg tagatgccta tttatcaatg 2450401 cttcgtatag acgggacact tgtaagcgtt ggagctcctg ccaagccgga cacatacagt 2450461 gtgttttccc taatcatggg gcgccgcagc attgcaggtt ctctagtcgg cggaattcaa 2450521 gaaactcaag agatgctgga tttcgcagct gagcatggca tcgaacctaa aatcgaagtc 2450581 atcggagctg accaagtgga cgaggcatac gaacgtatcc tccgaagcga tgtccgttat 2450641 cgatttgtga ttgatatttc cacattgtaa taggttagtc cttatatggg ctgccgcttt 2450701 tattgaaact cacgaaaaat gatctcttta agcaaatatt ttgaaggccg gtcaatcttc 2450761 ctgttattct atgaatagag agttattagg agggtttttt atgagcaaaa aaattgcagt 2450821 tcttgttaca gaccaattcg aagacatcga atatacaagt ccggtaaaag catacgaaga 2450881 agctggctac agtgttgtgg ctatcgattt ggaagccggc aaagaagtta ccggtaagca 2450941 tggcgagaaa gtaaagattg acaaagccat ctctgatgtg gatgcaagtg actttgatgc 2451001 acttttaatt cctgggggat tctctccgga tttgcttcgt gcagatgacc gtccgggtga 2451061 attcgcaaaa gcatttgtcg aaaacaaaaa acctgttttc gcaatttgcc acggcccgca 2451121 agtactgatt gatacggatc ttctaaaagg caaagatatc acaggctacc gcagcatccg 2451181 caaagattta atcaatgccg gtgcaaacta caaagatgca gaagtagtcg tcagccacaa 2451241 cattgtcaca agcagaacac ctgatgattt ggaagcattt aaccgcgaat ctttaaactt 2451301 gttaaaataa caagaaggca cagactgttc gggtctgtgc cttttttaaa attaagactc 2451361 cttcgttaca ttctgaaaga cagcagtcgc gtcccacaca ttcaagccaa attggccttc 2451421 tgaaaatacg gaatcatgtg catcaatcac aagacgatca tctaaataga ttttaaagcg 2451481 atcgccctcg gcctctgttt tcagatgata ctttttatta acgtctatcg gtgttttgta 2451541 ttcagcaatg acagaagcag caccgttctc aaatttaaag aatttcacta ggtcatgctt 2451601 cgcatccaca ttggcaaggt aaccgttttt ggcatctttg tcagagcgaa acattagtgc 2451661 tcctgcccct cttccgtttc catccttaat ggtgatatca gattcataag tgaagtctga 2451721 cccggatgct gaagacaaga taaaggaatc gccgtccgac ctcccttgtt tcccctcaat 2451781 tgtgtctgcc cacgtgccat ttacagtcgt ccagccagtc atattggaca taaaaggtgt 2451841 cgttccccat acctttttta aagggtgtat cgttaaagat tttaccttta caccgccatt 2451901 tgcagcatat aattcaagcc ctttgcttga tcggtctggg agaataatat ccgttatgac 2451961 ctgctttccg tcattcccaa atacttcaac cgaggagcgg tcaacaaaaa tgcgcaactt 2452021 aaccttccca tttaccggct tcaacggggc tgtttctttt ccggtgttaa aggccggatt 2452081 aaaggtgtcg ttgcctgact cgctccggtc aacgaacaat ttggcgttcc ttcggtcata 2452141 gccgaccttc gtaaattgat tttcacctgt tcggacctta aaaccaaatt cagcagctga 2452201 accagggctt actttaaatt ctgcatttat ttcataggca tctccagatt gccccgctaa 2452261 cacattatga cttgcaggcg atatggtcag attcttccac ttcttagagg ttccgcgaat 2452321 ggtttccagc tctttcaccg gtgtttggac cactctaacc ccttcggtaa acgctttcaa 2452381 ttttaactct cttggaatgg acgttgcact tctccatggg gatgtcggaa catcattcgc 2452441 atattgccaa ttgctcatcc accctaacca tagccggcgg ctgtctgtgg atggaatatc 2452501 agaccaggat acagccgcat aaaagtctct gccgtaatcc gtccagagaa ctttgtttgg 2452561 cgggttttca tttttaaaat gagttccatc aaagtcccct acaaaatatt gcatgcctga 2452621 tcctcccgag accgctccgt ttccgacact gacctgcatg acccatttct tttgattcgg 2452681 attgccgtct accggaagct caaataaatc cgggcattcc catactcccc cgtggcttcc 2452741 ttgatcctgt ccaaattcac ttgcatacgt ccactgcttc agattttttg atgtataaat 2452801 gaggattcgg tcaccggccg caagcaccat cacccacttt ttttctttct cataccaaaa 2452861 gacttttgga tcgcgaaaat cttttttacc cgggtttgga atgacagggt tgccagcgta 2452921 cttcgtccat gttcttcctt tgtcgttgct ataggcaata ctttgcactt gatggccttc 2452981 ccgatcctgt gtataaatgg ccacaagcgg cttctctttg cctgtttgaa aaccgcttgt 2453041 gttattttta tctacaactg cgcttccaga aaagatcgtg cctttttcat ccggatacag 2453101 cgcaacagga aggtgttccc atgtaaccaa atctttgctg acggcatgcc cccaatgcat 2453161 gggcccccac tgaagcccgt atggatggta ttgatagaac aagtgatatt ccccagcata 2453221 atataccatt ccgtttgggt cattcatcca gtttgcctcc ggtgtgaagt gatattgagg 2453281 acggtaatcc tcatcatagt agcttgaatc ggctgcatct gccgaaaatg ccatagtcaa 2453341 cagcagggtg aacatgatca tgacttgaat cagtctcttt ttcatttgtt ccttcgctcc 2453401 tctcttcatg tttgaacact ttcaaaagag actgctgcgc aagctggtcc gtttctggca 2453461 attctcctct gtttcactgt tatccgaatg atttatatat gaaaagactg ctgcagtttc 2453521 tctctctttc cttcacacac cttatgctaa gaatccagcc caatacccga gaatcccgat 2453581 gacaaagatg ccgcaaataa tgagaagtgg attcacccct ttgcgaagca tccatgccac 2453641 caataacgtt aatccgagag gcagcgcccc cggcataatg ctatctagca cgttttgtac 2453701 cgtttgaaca tctacttttc cgctttcatc cttaatcctg gatacaacga ttggaatgtt 2453761 gatggtggtc catttggaca cgagagcccc cataacaaat aacccgagaa tcgaagcgcc 2453821 ctctgtaagc ttttgaatgc gattccccgc taaatcctga agaatctcca ttcctttcac 2453881 atagccatac tttaatccgt aatattttgt gcttaatctt atggcattca gcaagaaaaa 2453941 gaatagcaaa ggaccggcaa tgtttcctcc taaagcaagg gaggctccta gcgcagctaa 2454001 gacaggacga atcgttcccc aaaaaattgg atcgcctacg cccgctattg gtcccatcaa 2454061 accgattttc attccgctta tcgcttttcc gtcaattcct ttattgttcg ccatttcttc 2454121 ttccatggct gccgtcacgc caaatatagg cgctgtcagc cacggatgtg tattaaacca 2454181 ttccaaatgc cgctgtaagg cttcgtttct tttcgctccg ggaccgtaca attttttgat 2454241 cgccggtatc atgacataac aatatcccat tgcctgcaca cgttcgaagt taaaggaacc 2454301 gagtaaaaaa tttgaacgaa taaacatgct gaaaatttct ttcttcgtta atcgtttttc 2454361 tttctccatt ttttcttccc cctcatcgtt taggcatcaa gatcatcatc atcgtcatca 2454421 taaacagcaa cactgccact gtctgatgcg gccgcgactg ctccgtgagc gctttgtttt 2454481 tgcatcacct gctggtataa aagcgccaga cagagaccaa gggctccaaa tcccactaag 2454541 ttaaaatcgg taaacgccgc taataagaaa ccaatataga aaaatggctt taaataagga 2454601 atattcatca tattgatcac catggcatac ccgacaacca caataatgcc tccgcctatt 2454661 tgcagtcctt ttgtaatgac atcaggaata tttcccagga acgcctgaac agcgctgaca 2454721 ctaattaaag caacaatcaa tgtaggaatc atgacgcgca aagcttgaaa caccatcgcg 2454781 gtaatatgca taatttcaat tccttttata tttcccgctt ttgcatattg atcagcgcgg 2454841 tggatgaaaa agacagtgat cgtccgaaca aaaatcgtca gcgcctgacc cgcagctgct 2454901 aaagcaacag cgacagcaat cccttcgcca attccttgat cagcggtaat aactaaaatg 2454961 gttgagatga cagaggcgat cgctgtatca ggtgccatgg caagcccgac gttcatccag 2455021 ccgagcgcca tcagctccag tgtgcctcca agaataattc ccgtttttaa gtccccgagc 2455081 accaagccaa ccaacgtaca ggccactagc ggccggtgtg tctgcccttc atccaataca 2455141 cttgcgattc cggtgattgc tgcaatgatt aacaacaaaa taatttgtaa tgaagacata 2455201 ttctcatccc cttgattatt ttgttacgtt ccgtaaaatc tgtacaaaat cctcactggc 2455261 atctgaaggc agctgcctca attccagttt cacgcccttg tcacttaatg tttcaaatgc 2455321 ctttatatct tgttctgtga cactgactga ttttgtgatt tgcctgcgat gattttcaaa 2455381 acgcattccc ccgacgttta cggttttgat cggtacacct gcttctataa gagatacaat 2455441 atcggacgga ttttcaaaca agagcattgc cgttacccct tcgtagcgcg gactatgaaa 2455501 tgcttttgcc attttagaaa ccgagacggc actcgccttt acatttgaag gcgcaacaga 2455561 aaggatcagc gtttttctca tttcgtcctg agcaatatcg tcggagacaa cgatgattcg 2455621 gtcggctgca tggactttta tccaccttgt caggatttgg ccgtgaataa agcggtcatc 2455681 aattcttgct aacacaatgt tcatcataat tcatcctctc ttgtatcttg attggctgtt 2455741 tttacttttt ctaaatgttc actgcacact tgaaagcttt gctgactcat tgcttttaag 2455801 ttgttcagca aatctttgag agccagatgt tctctcaggc ttaatacctc cagcagaatc 2455861 ggcaggttta cgccggcagc catatccatt ctttgatcct cagcaataaa ggaagctgcc 2455921 gcgttatatg gcgtccctcc aaaaatatcg actaaaaaaa gcacttcatg ttcttccggg 2455981 atatccttga gcgcctgatg atatttttct tgcagcgttt gtattccttc ccctttgaaa 2456041 aacggcactg caatcaggtt attttcttca ccgaatatca tccctgaaga ctcttttaat 2456101 gctatgggaa aatctccatg accgctgata ataactgaaa tcatatctat tgctcctttc 2456161 ctgttttgta catccatata taatgcaagg atcgtgccaa cacagttgtg ttaagcgttt 2456221 tcattgttat ttcagccaat agcaatttgt tgttgaaaca cttaaaacga aaaaaataaa 2456281 cctgtattaa aatggtgttc catttaatac aggttcatat gaaaaaactg tttttaaaac 2456341 agctggccat gcacttcttc agcaaatatg gcggctataa ataatttttc atcatcactt 2456401 atgcgaagtc cgagcttttc ttcataaggg gctaatgttc gctctgtcac gtacaccatt 2456461 tccttcagct gatcattgat ctcttcttcc tctgagaaag cgatcggatt ctgcttaatt 2456521 accctttcaa aggcgaaagc cgtgtgcata atgactttga tcaaaaccgc attattgaaa 2456581 atgaccccca gctcatcctg aacggtttgc agccactcca ataacatgtc gatcacatgg 2456641 tggggattca agaagacaag gtattttttc aggctatcct cgcaaagctc cctgacaata 2456701 atatttgctt cgttcaatcc attgctcaag gagatgcttc cttttgtaat cgcctgttga 2456761 atcagcttct ctccctcccc ttcaattaac acttctaaag atacatgcgg agcattgatt 2456821 ttagggtctt tcgttccgac tgtcgcaagg atttcatact ctttttcgat ttcttttatg 2456881 ctgttggcca gcttaatcga tgatacggtc aatatgtgaa tgggggtatc ggaggccttg 2456941 tttacgatcg tggttagaat gtcttccagc tttttggccg ttccgctacc cgtcgtgcag 2457001 atggatacca atgccttctt tttgccggat gccgctggct gacgctccca caactcgata 2457061 aaatccttcg tgaccgattg atagatcgca tgcaaattta aattcaaata gttgaccttt 2457121 ctgacagcat ccagcaccat tgaagtcgta acattgctga tcgttttaat agaaatgcct 2457181 gtcttttcct ccagcctgct ttccagcatt gcaagcgacc ccatatctac cagcattaaa 2457241 acaccttcac cttcatcaac ctgtttcatt ttttctgcta cgcattcaag aatgtccgaa 2457301 ggtgaaacag taagcggcat gtcaactgct gcaatcggcg tactccctag cagttctgtc 2457361 gcgacttcaa ccattgaact cgccgtgctg tttccatgag ctgccacgat aataccgact 2457421 cttttgttct cctttaacga tttgatggaa tgaattaaca tcgttaagta gatgacttct 2457481 atttcaggaa tagccacttt aaaatattcc tgaattttat ctttaaaaat catcgccacc 2457541 cgatattctt tcacatgggt atcacgaatt tcatctgtct cctgtgtatt caaaacatca 2457601 atttgctttc ctcgctttaa aaatgcgtca atatgcatac tcaagaaata aataaactta 2457661 cggtcaaatg tgcaatccag ctcatgttca gctatttctt ttaactgttt tgtcatttga 2457721 atcacatcgt cttcaacgaa tgtcagcagg ttgtcttttt gaaaagcttg atgatgaaaa 2457781 aaacttctga catgcaaatg gacatcagtc aagatgtact ggttaatatc ctttttggat 2457841 aaaccttctt tcataagcgt tttcactttt tcctcaatca aatgatataa gttaaatgag 2457901 aggtcttcgt caatttttgt tgtttcatct tctacaatcg gagagataat cgttgtaata 2457961 ttgacatatt cagaaatggc tttgcttctt tgcatgtttt tgctgctgga catccattct 2458021 tgcttgattt catcaggcag atcgcgaaca gtcagttcaa taacttcatt tctgtcaagg 2458081 ttatgcaaaa atccgtgtgc gcaaactaac tgaacatttg atttcagctg tccgacattc 2458141 ccaaatttcg cagagtgaat aagcgcatta tagacatcga tatgcacact cagattcttc 2458201 ttaattcgct ctgcttcttt ccctaataaa aacgtcgtca gatccactct ttcattaagc 2458261 gatcgttctt caagcgaagg aatatgaatg gtcattggga ttcttcgcaa aaacgttttc 2458321 aatagtgcag aactcggatt ttctgtagtc gcacaaataa acaatacgtt cgatgttcgt 2458381 ttatgttcag attctccaag cctgttataa gaaccgctgt caataaaata aaacagcatt 2458441 tcttgtccct cgggagggag acggtggatt tcatccataa aaagaatgcc cccattggcc 2458501 tgttcgacta aacccgcctt atcctcggca gcacctgtaa atgaaccttt tttgtgtccg 2458561 aataattgag aaagcaataa ttgagggttg ttgtagtagt ctgcacagtt aaatgtaata 2458621 aatggtgcgc cggccttcaa tatgtcagag taaatggcaa actggtaaat tcggttcgca 2458681 aaaagggatt taccggaacc agtcggccct aggaggagca tatgcagacc gttcggcgga 2458741 taaaagacag ctgcttttgc ctgggagatc gctttcttca aactcccttt tgcccctatc 2458801 ataagctcta ggggattcgt ggaaatgtgt tgatgatttt gctttgaatt tccggaaaac 2458861 gcctgaaggt ctttcacttc catcatctct gtatcccatt tcttgttgaa taatttttct 2458921 gctatctcga ctgggatgta tcttacagga aatgttttaa ttttgatgac ctttttggac 2458981 cggacgagat tgttcaattc aaagctgaca ttggaccgct ccattttcag ctgctcggca 2459041 atctcctttg ctgaattccc ttgtattttt aaaagatgat ctaaggttga atcatgaaaa 2459101 ttatgcttga gctgatggta tattttatct attcttctca cgtctatcat cctttgtcct 2459161 tattagataa gccattaaca agaatatttc gaaactttat agtccgcgtt gagatttaca 2459221 cgtttaaaaa ggtctctata gcagattgac aaagctggct tttatgcgta tatgtttaca 2459281 tgttgaatca tttgcacctc atattagtat gatagatgct cagttctgga gggccagtcc 2459341 ccttcaaaag taataatcag taaacagttt atcattctcg gggaatgtaa tgatgtcaaa 2459401 ataatcaatg acaaaaaatg aatcttatag atcatgacaa attacccaaa tataacccct 2459461 taagttcgtt cacaactaaa aagacggaca ctctatgtga ccgccacagt attacaattt 2459521 gcaaaacttc gtcatttttg caatccacat tggaggttaa ggaatctgta agcttaaaaa 2459581 ctttatctcc gatcctatcg atttgatccc cctgccggcc tcaatcatag tgggtatgca 2459641 attatacaaa tcgttaccga ttaaaactag cctgtcagat tgtccaaatg actttcctgt 2459701 tttactctgc tattcaggta gaatcacgag tgaaaaatag agccacaaga catgtaacag 2459761 cacttaaaat agttttaaaa tttaaaaata aaagtatcta ttcttttaaa tgttataata 2459821 tccgataaaa ctttactcat ctttttatta ctggaggaaa ataaaattga taggcaattc 2459881 tagcaaagac aattttggcc agcaacagaa attgtctaga ggccttaaaa acaggcatat 2459941 acaattaatg gcgattggag gtgcaatcgg tacaggttta tttttaggtt caggtaaatc 2460001 catccatttt gcaggaccat ccattttatt tgcttacttg atcaccggcg tattttgctt 2460061 tttcattatg cgttcgctcg gagaactgct cttatcaaat gcgggatacc actcttttgt 2460121 tgattttgta agggactatt taggaaacat ggcagcattt atcactgggt ggacctactg 2460181 gttctgttgg atttccctcg cgatggctga tttaacggcg gtcggcattt atacgcaata 2460241 ttggcttccc gatgtgcctc aatggctgcc gggtcttctt gcgcttatta tcctgctgat 2460301 catgaacctt gccaccgtta aacttttcgg agaattagaa ttttggtttg cattgatcaa 2460361 agtcattgcc atactggctc tgatcgtaac tggtattctc ctgattgcga aaggtttttc 2460421 cgcagcttcc ggccctgcca gcctcaacaa cctttggagc cacggcggca tgttcccaaa 2460481 tggatggcat gggtttatcc tatctttcca aatggtcgtc ttcgctttcg tgggtattga 2460541 acttgttgga ctgacagcag gtgaaacaga aaatccccaa aaagtgatcc ctaaagccat 2460601 caatcaaatt cctgtccgga ttttactttt ttatgttggc gcacttttcg tgattatgtg 2460661 tatctatcct tggaatgtgt tgaatccaaa cgaaagccca tttgttcagg tcttctctgc 2460721 agtaggcatc gttgtggctg ccagtttgat caattttgtt gtattaacat cagccgcatc 2460781 agctgcaaat agcgctttat tcagcacaag ccgaatggtc tattcacttg caaaggatca 2460841 tcacgcacct ggactattaa agaaattaac ttcttctaac gtgccaagca atgcgctgtt 2460901 cttttcatcc atcgccattc tgattggcgt tagtctgaat tatttaatgc ccgagcaagt 2460961 cttcacgctg attacaagtg tttcaacaat atgcttcatt tttatttggg gcatcacggt 2461021 gatttgccat ttgaaatatc gaaaaacaag gcagcatgaa gcgaaagcaa acaaatttaa 2461081 aatgcctttt tacccattat ccaactattt aacacttgca tttctcgcgt tcattcttgt 2461141 catattggca ctggcgaatg atacacgtat tgctttgttt gtcaccccgg tctggtttgt 2461201 tttattgatt attttgtata aggtgcaaac ccgcagagga cataaggtga aataaaaaaa 2461261 agacaaggga tactcactcc cttgtctttt tatatgtgtc aaacactaaa ttaaactttg 2461321 gtttcaaatt tcattcactt catttaagtg ttaactcaaa ccagttttga tgccgaaacc 2461381 tactaatatt attccggtaa ttttttgaaa cactttctgg aacttcgagt ttttcatcca 2461441 tttttttgcg taatcaataa tataaacaag aaacaggaac cacaacaccg ctaataaggt 2461501 taggattgaa gctaaaatga tgagctgctg gtttatattt ccgttcaaat tgataaattg 2461561 gggcatgatt gtaacataca ccaaaacagt tttaggattg agaatgttac tgagtgatcc 2461621 ctgcataaag gaagttttat aataacgttt cggagaactt gccatatttt ttgcttggga 2461681 ttgcatgtca tctaacgaaa acatactttt agcaaaaaaa ctttttacac ctaaataaat 2461741 taagtatgcc gctcccaaat atttgatcgt tgtgaaaaga atcactgact ttgcgattac 2461801 cactgataat cctaaaatgg caatcaccgt ccaaaaggaa agtcctgtcg ccaatccgag 2461861 aatgttataa cggccggctt tcggaccata cctaagcgta tttttcatca caagcatcgt 2461921 atctgccccc ggtatgataa ccatcatggc agcgatcggt atgtatgcga gtaagctgtg 2461981 cattgttctc tcccccttta aaaatcccct caatcatata gtgactacaa aagtaactac 2462041 ttataaaagt gtatcaatgc gtttggaata aatcaatatg atttgttaaa atagcgatta 2462101 ctaaggcagc gattgctctt tatattggag gatatatgaa agaaaatatg ttagacattt 2462161 taaaaaacct caattttaca gaatatgaat cgaaagcgta tttagcatta ttgcaagaat 2462221 cacctttaac aggctatgcc gttgccaaaa aatccggagt gccccgttct aaaatttatg 2462281 aagtattgga aagtcttgtc ataaggggag atgtttttgt cagtcatgga aatacgcctc 2462341 agtatgttcc agtccccgca aaagaactga ttaaaaaccg ccggctcaaa gcggaagagc 2462401 attttgatca ggctgagaaa tattttgaaa agttcgagca gaccgcaaat gaccgggaaa 2462461 acatctggaa tatcaccggc cgcagtgaaa ttcttgaaaa ggtgaaggct tgtatcttat 2462521 ctgccaaaaa aagaatcctc ttagaaatat ggaaagagga ttttaaggag atagaagcag 2462581 agctcaaaca ggcggcagaa caaggcgtta ttgtcaccat tattgcgtac ggagacatcg 2462641 tatctgattt tgccaatgtt taccttcatg atatgagcag tgaaattaca gaagagtatg 2462701 acggacggtg gcttgtctat agcggagatg attcagaagt agtagcgggc attgtctcac 2462761 ttggcaacga cagccgtgct gcatggacga tgcatgtagg gttagtcatg cctattactg 2462821 aagtgatcat tcatgatctg tacctcatgg aaattctgaa aaagcataga gagcttttag 2462881 aagagagctt cgggaaaaat ctcatccagt tgcgccgtaa attttctatt cactcagatt 2462941 tcaaaaaaca ttatttggaa taatgtttgt catctcttac cccaaaaaca aggcttgtac 2463001 aaaacaagcc ttgttttttt atgcataaac cccccatgct gatttacttc tctcttttaa 2463061 aaaatgtgat tctgcgcaaa ctatttttca gcctgccgcg tctatcctag gtaacagcct 2463121 acgatatacg tatattcaaa aaggagccct ttattgcaat gaagaaaaaa caaacaacaa 2463181 aagcgttgct tgtcacatgc ataactgacc ataagcaaga tttctacagg ttggctttca 2463241 gttatgtgaa aaatcaagat gacgcattag atattgttca ggaatctata aaaaaagcgc 2463301 tgagctcagt tgaaacggtc aggaaccctg agacgataaa aagctggttt tataaaattt 2463361 tagtacggac agccattgac tttttgcgca aacaaaaaaa gataagagtg atggacgacg 2463421 aaacgataga atttttaagc aaaggaaagg aagaccatta caaggatact gatctccatg 2463481 aagcgcttga cgaattgccg taccgctata aaaccattat tattttacgt ttttttgaag 2463541 acctcaaatt agaagaaatt gcggaaatta caggagaaaa cacgaatacc gtcaaaacgc 2463601 gcctatacag agcattgaag ctgatgcgca ttcagttgac gaaggaggat ctttcttaat 2463661 ggataagaga ttacagcaat taagagaaga atataaaaat gttcagattc ctaaagaatt 2463721 ggatatcatt gttgaaaaag cccttcagca agaaccaaaa aagaaaagaa tcgttatgtg 2463781 gccgacatca gcagcaatcg ctgcagctat tttattcact gcgcttgtta atatcaaccc 2463841 ggacgccgct caggctatgt caaagatccc tgtcatcggc aaaatcgtca aagcgatcac 2463901 ctttattgaa atcaaagagg aaaaagacca atcaagcatt gatgtcaaaa cacctgcttt 2463961 gtccgggctt tctaataaag agcttgaaaa cagcattaac gagaaatact tgaaagaaag 2464021 ccagcagctg tataaagagt ttatacagtc cacatccaaa aacaaaaaag ggcatctcag 2464081 catctacagt gattacgaga cggtcacaga cacgccagat ttactctcta tccggcgcaa 2464141 tattgaaaca acacaagcat cttcctacac acaaagccgt tatattacaa ttgacaaaaa 2464201 gaatgatatt ttacttacat taaaaagctt attcaaagat gagcgctata tcaaagtcat 2464261 cagtcaaaac atcaaagaac aaatgaaaca gcaaatgaag gaagatccaa ataaaatata 2464321 ttggctcact gacgaagatg cagaaccgtt caaaacgatt cttcctgatc agacgtttta 2464381 cattactgaa gaccataaac ttgtgatctc atttgacgaa tatgaagtcg cccccggcta 2464441 tatgggcgtt acagagttta caattccaac cggcgtcatt tcaaacttgc tcgtgggaga 2464501 acgttatatt cgataaaata aaaacatcca tctaagatta tggatgtttt ctctcttctc 2464561 tattcgaggt cgtaaccccg ctatcaaaaa caacgagaat atttgcatac tattggagga 2464621 atacccatgt atcacaagac acagcatcat cgatacattc ctggacttga tggccttcgg 2464681 gctttcgccg tcctgtcagt tatcacttat cacctaaatt tcaattgggc taacggtggt 2464741 tttatcgggg ttgatatctt ttttgtttta tccggatatt tgattacatc tattctatta 2464801 ccggcatatg gaaatgatat caatcttgat tttcgggatt tttgggtgcg ccgcattcgg 2464861 cggcttctcc cggcagcgta ccttatgatc ttttccactg ttgtgtgggt cgtattgttt 2464921 gatcgagaac tattgcacac tgtacgtgga gatgcgatct cttctctctt ttatatgagc 2464981 aattggtggt ttatttttca caagctatca tattttgata gtttcggttc cccatcacct 2465041 ctaaaaaacc tttggtcgct ggcgattgaa gaacaatttt atatcatatg gccgatgttt 2465101 ttagttgttg gaatgtacat aatgaaaagc cgcgccagat tggctgcggt gatatcattg 2465161 cttgtgcttt gttcagccgt gatgatgagc gtactgtatg aacctggcgg agatccgagc 2465221 cgcgtttact atggcacaga cactcgttcg tttgaacttc tcatcggatg tgccttggct 2465281 ttggtatggc cgatgaaaag gctgtcttcc aacaggctgc caagcaaact gaagcacact 2465341 ttgcacgcca ctgaattttt ggcattttgt attttagtgt tgtgtgtcta tttcacagat 2465401 gaatacgagc cttttcttta cagaggcgga atgctattca ttagcgtgac tgccgcaatc 2465461 cttattgcat gtgtttgcca tccgagcagc tttttaggca atctgctttc atggaggccg 2465521 cttcggtggc ttggaacgag gtcttacgga atttatcttt ggcactaccc tgttattgtg 2465581 ttaagcacgc cagttcaaga aatcggaaac cctgtttttt ggcatatcgt gctaaaggtc 2465641 attgtgacat gtatacttgc cgagctctcc taccatttta ttgagaagcc gatacggaca 2465701 cagggattta ggtcattttc ccgccgtgtt tttatacata gaatcaagga atggaaaacg 2465761 acatctgtca tcagcaaaat gtcaattggt ttcattattt tcgctatact tatttttgca 2465821 ggcgggctgt cagggctagc cggcgagcaa aagcacccta ccaaatggac ctatagctca 2465881 caagaaacaa atgctgacac cagccaggct tctggggata aaaagaacgc tgcagcagat 2465941 aaaaaacaca atcctgaaca aaagacaaca gattccaatc agggtcaaaa ggaaaacaaa 2466001 gatagtgggc aagagactca taaaaagaaa gacacgcaat cccaacagtt gaaaaaacca 2466061 gcagacactg cgaaagaagt tttagctata ggagattccg tcatgcttga tatttcttca 2466121 cacctgcgtc agtcattttc aaatgtgacg attgatggaa aggtagggag acaaatgtct 2466181 caagctttgg aactcgcaag ggaatacaag tcttttaatc agccgaacaa ggctgtcatc 2466241 attgagcttg gaaccaatgg ctattttaca aacagccaaa tcgaacaact gcttcaatct 2466301 ttctcaaaag ctcatattta tcttgtcaat acacgggttc cccgccaatg ggaaagcaag 2466361 gtaaatgaat ctttgcagca acaggcccac gcacatcaaa atgttacgtt agttgactgg 2466421 catacagaag ctcttcagca tccggaatat tttacccctg atggtgttca cttggttcct 2466481 aaaggggcaa aaactttgac tgctcttatt gttcaggcga tgaaatcgta aaaaagagat 2466541 cctatacaga tcactttttt actttagttt ctgatcgttg attatgtctt ctttcagcaa 2466601 ggcagccctt atgtttacat gccgtttacg taagggtaag ccaaaattga atggagggat 2466661 gataatgaaa ggaaatgaag aacatgacat ccaaaaagag ttgaaacgat atgagctttt 2466721 tttcaaaaaa cgatataagg ttctttatac agtaaacgat tttatcatcg gtgctatgtt 2466781 tctcgttgga agttttttct ttttttatga ccggttaatg tcggcaggga tatggctgtt 2466841 tgcgatcgga agtttgctgc tgttaatcag gccgaccatt cggctgattc atgactttca 2466901 ttaccgtaag catgtggaac agcaattcaa gcatcaatct tcaacagatg actgatctta 2466961 aggaataaga aagaacaaaa tgccaaaagc ctgagtcgaa aatcaaaaac aagactttca 2467021 gactatttat ttttaaaaac aaggtaaaaa gaactaaact tttgcctctg catgccgata 2467081 tgaataataa ggccggcgcg atactcccta taacatcctt ttcagtagat ttcattatcg 2467141 tgccggtttt ctcatatgca aagcaatccc gccaatcaga ttggcgggat tttatatttt 2467201 acattcctgt ccaaacgtct ttcacataac gtctttgatc ttgcagcttt tgcagccata 2467261 cagctgattc ttcctgactt gctgcttttt cagcttcata tgccaatcgc aaagttctct 2467321 ctacatcagg agccatttgc gatccatcac cgcatacgta aatatgagcc cctttttcaa 2467381 tgagtgtcat caatttctgc gtatcttgct tgagcaagtg ctggacatat ccttttggtt 2467441 cgttttcgac gcgcgagtag catcggcgga ttgtgaccaa accgtcctgt tccgcttgat 2467501 ccagctcttc tctgtaaagg tcgtcatggt ccgggcggcg gcagccgaag tataaaagtg 2467561 cttcaccaag ggtgcttcct tccttcttca aaaccgatct tgcctgaata aagcctctga 2467621 atggcgcaat tcctgtgccc ggcccgacca taatcatagg cgtttcagga tcattcggca 2467681 tctgaaatcc ggactgcggc gtacgaatga agcaagctgc tgcatcacct gtattcaatt 2467741 ctgctaaata attagaggcg acaccccggt attcacctcg gccgctccat gctgaggctt 2467801 tcacaactcc taccgtcatg ctcacgatat ttgcatgaac tttcggtgag cttgaaatgg 2467861 aatagtatct cggttttagt gatggcaaaa gtgctaaaaa ccgttcaaac ggcatttcgc 2467921 aagcaggata atcctctaaa aaatcaagca tggtaagacg ttttgcaagt acctgctctt 2467981 tgtaaatgcc atcatctgaa acgagctgtt ccagctcttt ttgatgcggc ggacaaactg 2468041 tataagaggc cagctcccga agctgaagcc ttgatgccgg ttcctgcagc tctacatagg 2468101 acgacaataa atccactact ttgattggcc gatccatcgg cagatgagcc atatgagcgc 2468161 ttccgcttac ttttatcaca tgattggact gcaaaccgaa tcggctgaga acccgctgaa 2468221 caagctccct gctgttcttt ggcaggattc cgatatgatc gccttcttta tatgttttac 2468281 cagccggaat ttccaattca atatggcggg ttgaacgcgt gctggcagct gtctggagtt 2468341 ctcgattctc taacacaatc ccttcaaacg cgccatatgc tttagcaacc ggcgtttccg 2468401 tcgcttcact gagaaaagta atcgataatg aaggcctgtc ttctttctgg gctatttcgt 2468461 taatatcaaa tgcgtccatc gtttccttcc agaagcggtt ttcccaagac tcgcggtggc 2468521 tttcaaaatc atcggcggcg tcaccttccc caatcgctgt taaacgcgat gccccctttg 2468581 ctttcatcat gtcatcaatc aggcggggaa tccgctgata cgtgctggcc cagctccggt 2468641 ttccgcagcc gaataccgca taggaaacac ctttcaattg gccttcctca agctctttca 2468701 gccactctac aaatccggca gcattatcag gcggcgcccc attataagaa gccgttacaa 2468761 tgacgactgc cccttcttca gggagcttgc cgatataatc atcaagcgga gccgtttcag 2468821 ctgtaaagcc catctggcgg ccttgagcag ccagttcacc ggctattccc tcagctgtcc 2468881 caagatttga accaaaaaga acaagtaaag gtgtgccgtg tttaggtttg gtttcttttg 2468941 gctttgtttc tgctttgatg tctgcctgtt cttttctctg tacattgatt gccgctgttt 2469001 ttcgcggttt cacagtaatt ttaaaatcat ccggcttgat cgttaatgct tctttgattt 2469061 ttagttcgta gccagtatgg tttatcaatt caaaatgctt taatacaaga ccgagaacca 2469121 ttgtcgcttc ttgaagagca aactgcatgc caatacaagc gcgctgtccg tttccaaacg 2469181 gcttatacgc atggtgaggg atacttgaag gatcctcaaa ccgttccgga cggaaatctt 2469241 ccgcatccgg tccccaagcg ttttgatccc ggtgcagttt tggaattaaa acagtgactg 2469301 gctgcccttt gctgatcgga tattccccgc ctagaacagt atcctccttc gcatatagag 2469361 aaaaagccgg agctgttgga tacagtctga gggtttcatt taaaaccatc cgaatgtatt 2469421 tgagctgctg gatttgttta tattcaggcg tgtcatccgt taacacgcga tccgcttcct 2469481 cctgagcttt tttcagtttt tccggatgtg taagcagaca ataaatcgca aaggatagca 2469541 acccgcttgt tgtctcatgt ccagcaatta aaaatgtgat gatttggtat cgaatgtttt 2469601 cgtcatccag cgtttcaccc gttactggat ctttggcata aagcatgaga gacaagagat 2469661 ccttaatgtt ttcatccgga ttcgcctttc gctccgctat cattctatca accagggagt 2469721 tcatgacttc tatatccttt tggaactgca gcttcgtttt caccatcatt ttatcttgca 2469781 ggcccagtct tttcgattga ttcatcgcct cttttaaggc acggagcata ctggtgataa 2469841 acggatgctg tgaatcacgg taaaagctgt tgaatcgata gttaaacccg cataacccaa 2469901 tcgtatcaag cgtcagacgt gtcatatcgt ccgctacatc aatttcttca ttagggttta 2469961 accggctcca cttttgaatc agctgggttg cgatatccag catcatagaa tgatagcctt 2470021 tcatcgcttt ttgactaaaa ctcggcagca aaatgcggtg ggctttttgc cagttcggtt 2470081 cgtgcgtcca gcttgtaaat aagccatctc ccccgaactc acgcaccttt tgcaagcctt 2470141 tgccaaggtt cttgtcaaag cgtttttcat cacacacttc agccacaaga ttgtggccgg 2470201 acacaaaaac actggatact cccggaaaat caaaacggaa aatcggtccc aattcatcag 2470261 ctatccgcca taaggattga gaaagctgtt ctttttccag atgcggaaga ttttttaaag 2470321 gtccgtatgt tttgggctga ggtattgcgc ttgcctgttt cattaacatc tccctttcct 2470381 atttttgtga tgaatgaagc ttaatggcgt cccagcagca ttgttccaat tcagtaatta 2470441 aatcagtgtc catctctata tcacctgttt gaacgagctg atatatcttg agaaacgccc 2470501 ctaatacaat cgcaattaac acattagagg gcaggctgcg aatcacgcct tccgcttttc 2470561 ccttattaaa atagtcatca agcatttgag tcagattttc tatcattttt ttgcttgtat 2470621 gatttaagta atgagcgtct tttttggttt caagaaaaaa aagcgcatag tcgctctctt 2470681 tcgtaaactg aacgagacag caaaatacgt ggtgaaagcc ttctctgaca ggcaattctg 2470741 aaacgtcttg cttcagtttt tccgtaaatc gctggatgct ttcttgaaac agtacgttaa 2470801 cgagtgtttc tttgctgtca aaataacgat agatcgttcc tgtccctaca tgagcacgtt 2470861 cagctatcat aggaatagtg gtagcgtcaa aacccctttc cgtaaaaagt gagactgacg 2470921 ctttcataat catgtcgtat ttactgctgg atgcggatat catgtaatct gacaacctcc 2470981 gattcgttta cggaatgaat attcattcct tttgttcaca aagaatgtct gccctgtctg 2471041 atatcacctc tttgttcttt cttctgttat aagtttatat gaaaaaaact ttttttaata 2471101 taaagtatat gcaaaaaata aaaaattaag aaaatatacc caaatcctaa tacgaggatc 2471161 ttggatatat ttcccgagaa attttttatt taacagccac aatacataga caggaagcac 2471221 gcctgataac agaaagatcc ctgaaatgct ggtctttcag cagttgaata tacgttttct 2471281 ctttttcacc ggtatttgtg tcaatactga tataaaaccg gccgtcaatt tgaagcaccc 2471341 tgtaaatttc tcttaatgca agcctaatat cggtgcagct ttgaaccgta tgtaaagaaa 2471401 agactttatt aaaggtacgg tcatcaaagg gaatgtcctc tggatagcca tgaaaaacct 2471461 ccccgttccc catgttcttt cgattcgcac gtgatatctg tcttaccttt cgttttgaag 2471521 gatcaatgct ttttaggcta ccctttttta gtttcttggt tatgctttta aagacagtgc 2471581 cgtttccaat tccaatttct aaaattctgt cattttcttg tatatctata gagtcaatca 2471641 tcatatgctc aattgttttg gttagcttat atttccgaga aaataatttc caaaaatccg 2471701 atcgtttata gagtctattt tctagcattt taaacacctg cttttggttt cctatgttta 2471761 tttattatct taaaaaaata aacatcatct tcatttctaa aagtgaagga aggtaccaac 2471821 tagacggcaa tgtattgaaa aatgtttcaa tagaactaaa ctttttcatt tttttccgaa 2471881 aaaaaagcag aaaacataat gttttctgcc ctctttctaa tgccaatgat aagggaatac 2471941 atacagcctt tgctgctgca ttgccatcag cctctgctgt cggaatggat ttccataacc 2472001 atgtttgaag gaatgcggca tggacgcata accatggcca atcgacggca gtcttttttg 2472061 ataatcgttc atcatgccat cacctgcctc acaataacgt tgatttacta tatgcaggcg 2472121 cgcattttct tgacagctat ttcgctaaac ttggtccttc tccattgtat aatgcatcaa 2472181 tagttccatt ctaagcatat gccattcccc cttcagtttt tttcgttgct tttagcgcca 2472241 gtttgttaaa taaagatgct ttaactgaga ctctttcatt tcatcataaa tttgttcaat 2472301 ctgctgttct cgttcgaatt cttccaggct tttaaaccgt tttttaatcg ttaacgttaa 2472361 aaagaatagg ttaatcgtca tatcgctcac cccctttcaa agtccgcatc aagcgaaata 2472421 acccgcggca caacccttct gccgcgggca aataaaaacc gcagacaaaa gaagacacca 2472481 atgcctctac tgcctgcggg gagttgcgta tgtccgacta ttccgaattt aatgcgtgcg 2472541 ataagcatcg gttaaggaag gacacgaact cttccacagg ctgaataaac catgaacttt 2472601 tacatgtgta tcacgtacag gttgacgtcg ttgtctcatt gtcattttgg ttcagcctcc 2472661 tttgcttttt tcttactttg taagtatatc caccaaattc cattttgtaa acatcttttt 2472721 ctaaaaatgg acggaaattg tgcaaatcat cgaatggatt tgcccgttgg tcatgacacc 2472781 tgcttcattt cttttctgga gcggtctttc ttatgatatg caataaaata aatgagaccg 2472841 acaaatacag ctccgccgat gacattaccg ataaaagccg gaatgatgtt tccgatgaac 2472901 tgcccccacg tgaatgagcc tgcaaaaatg gcagcaggaa tcacaaacat gttggcgaca 2472961 acgtgctgaa atccgatagc cacaaaagcc atgattggga accagatgcc aaggattttt 2473021 cctgctgcgt cttgggcgcc gaaagaaagc cacactgcaa gacatacaag ccagttacag 2473081 ccgatggcgg aaatgagaac cttgccaaag ctcatatcaa gctttccttg ggcaacggca 2473141 atcgtttttt ctaaataagg acctgtttca gtcaatccaa ccaaatgccc gaaaaagtaa 2473201 gcaacaaaca atgcgccgat taagttcata attgtgacga ttccccagtt aatcgctaac 2473261 tcttttactg atatttttct cgaaaataac gccatcgcaa ctgacatcat attgcctgtg 2473321 atcagttcag cgccagcgag aacgacaagg atcaggccga ctggaaatac tgctgcacca 2473381 atcaaactgg acaggctccc ccattctttc ggaagatcgc caattaccct gatatcaagc 2473441 aaatacccaa gcgcgataaa tgcaccgcct aaaaacccca gcacaagcag tgacggcagc 2473501 gggagcttta tttttttcat ccctgcttca attgctgctt ccgctatttc atccggtttt 2473561 cgaaaagcca taataaaacg cctccattac ttcttctttt ctcacagtta tgcaagaaag 2473621 gcaataaaaa aggcagcact caaataacct gtgtcaaacc aggcgtttga atgctgccta 2473681 acttgtatgc atacccatac aacaatatca agcagtatat aagatattga aagagaatat 2473741 atacagttcg tgcatacatt ccattgcttt agccttctat aactgtagca acatcatatc 2473801 aaatgtgaca aatttgtgtc aatgacaaat atactagctt tgcagagctt ctttttgctc 2473861 atctattttt cggtcaaaaa caaatacaga tacagcgatg ttttcctcaa ttttaatatc 2473921 agaaaacaaa tggactagct tagctcccat aagttcctcc attccttccg gtgtttgttt 2473981 ggaataaagg tcttgaatta ggcttgtccg ggccgcatgt accatctctc ttccttcagg 2474041 cgtgcgggca ataaactgct cgcttgcact cagatttccg tatagtgttg aaactgccat 2474101 gttttctaca aatacagtat gaattctctc aggccctttt ccgaacaatt ctttgcgaag 2474161 ttttcgaata atatcattga attcatgaat ttttttagac atgctgatta ccccttccga 2474221 tattgcctta taaaggcttt tcccggttcc cctcaggaca tttcacttgg ttaaaatttt 2474281 cctgccatat tgtattataa taaatatcac attataataa aagcagtgtt gatggatttg 2474341 taataggatc ttgttatgag tctatcgttt tataaaaatc aaggattggt ctgttagtaa 2474401 gacttgctag tgaactattc cgccatgtgt gtttacacct tcttagaatt aagggcaggt 2474461 gtatctatac atggcttttt ttgacttctt gaaagaaaga tggaggggaa tatgaatatg 2474521 atggacgtta agtcgatcag tgtccgtgta gacggaacag aaattcaagc acgagcaggg 2474581 gccacaattt tagatatttt aaatgaaaac ggaattgagt acccgcagat ttgccacgta 2474641 ccagaggttg acccgattca aacttgtgat acttgcatag tagaggcaaa cggcaagctg 2474701 gttcgttcat gcgcgacggt tgcagaaaac gggatgtcta ttgatctttc aggaaatcga 2474761 gtgaaagaag cgcaaaccga agcgatggac cgccttcttg aaaatcattt gctgtattgt 2474821 acagtttgcg ataacaacaa tggaaactgt acgctgcata atacagcgga aatgatgggg 2474881 atcgagcatc aaaaataccc atacacgcca aaagaagatc cttcttgcgc ggttgatatg 2474941 tctcatcctt tttaccgcta tgatccaaac caatgtattg cctgcggcca gtgtgttgag 2475001 gtctgtcaaa accttcaggt aaatgaaaca ctctcaatcg actgggaacg cgaacgccct 2475061 cgcgtcattt gggatgaggg agttccgatc aatgaatctt cctgtgtcag ctgcggtcag 2475121 tgtgtaacag tatgtccatg taatgcactg atggaaaaat caatgctcgg gcaggctggt 2475181 tttatgacag gcattaaaga ggacgtcatg gaaccgatga ttgatctcgt gaaaaatgtt 2475241 gaaccggggt atggcagcat ttttgccatt tctgaagtcg aagcggcaat gcgtgaaacg 2475301 agaacgaaaa aaacgaaaac tgtatgtacg ttctgcggtg tcggatgttc atttgaagta 2475361 tggacaaaag gacgggatat tttaaagatc cagcctgttt ctgatgctcc ggttaacgca 2475421 atttccacat gtgtcaaagg gaaattcggc tgggattttg tcaattcaaa agagcggatc 2475481 acaaagcctt taatccgtaa aaacggagcc tttgtggaat cttcttggga agaagccctc 2475541 gatcttgtcg caagcagatt aggatcaatt aaagagcagt acggtaaagg ctctgtaggg 2475601 tttatttctt cttctaaaat tacgaatgaa gaaaactacg tcattcaaaa actagcgcgt 2475661 caggtatttg aaacaaacaa cgtcgataac tgctcacgct actgccagtc tcctgctaca 2475721 gacggattgt tccgcactgt cggcatgggc ggtgacgccg gcacgattaa agatattgcc 2475781 aaagcaggcc tggtcatcat tgtcggtgcc aatccggcgg aaggacaccc agtgctcgca 2475841 acacgcgtca aacgggcaca caagctccac ggtcaaaaac tgattgttgc tgacctgcgt 2475901 aaaaatgaga tggctgagcg atctgatctg ttcatcagcc ctaaacaagg cacagaccaa 2475961 gtttggctga tggctgttac gaaatatatg atcgaccaag gctggcacga tcaggcgttt 2476021 attgatgaga acgtcaatta ctttgaagat tataaagaaa cccttaaaac gtatacgctt 2476081 gattatgcag aacgcatcac aggcctttca aaagaaaaca tcattcaaat tgctgaaatg 2476141 attcgtgatg ctgacggcac ttgtgtcctt tggggaatgg gtgtcacaca aaatacaggc 2476201 ggttctgata catcagcagc catttcaaac ctgcttctcg ctacgggcaa ctatcgccgt 2476261 ccaggtgccg gcgcttatcc tctgcgcgga cacaataacg tgcaaggcgc atgtgatatg 2476321 ggaacattgc ctggctggct gccgggatat cagcatatta cagatgacaa agcacgcgct 2476381 aaatttgaag aggcatatgg tgtcgagatt gatggaaagc ctggtttaga taatattcaa 2476441 atgcttcatg ccattgaaga aggaaaaatg aaagctatgt atcttgtcgg tgaggatatg 2476501 gcactggtcg attcaaacgc gaaccatgtg catgatattt tatcaagcct tgatttcttc 2476561 gtggtacagg acatcttcct gtcaagaaca gctcaatatg ctgatgtcgt cttgccggcc 2476621 actccttcac ttgaaaaaga cggaacattt accaacacag aacgccgtgt ccagcgattg 2476681 tatcaggcgc ttccgacgct tggtgacgca aaaccggact ggtggattat tcaagaggtg 2476741 gcaaaccgtt taggagcgaa ttggaattac agccatccaa gtgacatttt ctctgaaatg 2476801 gcgagtcttt ctcctctgtt tgccaaagca agctatgagg tgcttgaagg ctggaacagc 2476861 ttcctatggg gcagcttcac aggtgaaagc acaccgcttc tgtatgaaga cggatttaat 2476921 ttccctgaca aaaaagcccg ctttgccctt tctgattgga ccgagccagc ggcatttccg 2476981 gaggaatatg accttcatat caataacggc cggatgctgg agcatttcca cgaaggaaac 2477041 atgacaaata aatcgaaagg catccaagcg aaagtgccga atgtattcgt tgagatctca 2477101 cctgagcttg cacaagagcg aggtgtttgt gacggttcgc ttgtacggct cgtttctccg 2477161 ttcggagcag tcaaattgaa cgcgctgatc acagaccggg tacggaaaaa tgaactctat 2477221 ttgccaatga actcgacaga caaggagtca gcgattaact tcttgacggg ccctgcagct 2477281 gataaacgga cgaacacgcc tgcttataaa cagacaaagg tccgcatgga agtgcttggc 2477341 ggctgtgaaa cagcgccgct tccaaaaaca aatccgcgca acaaaaaacg gcatccgcaa 2477401 aacggagtcg aagcagaaag aaaatggaac cgccctggct atgtacatct gactgattaa 2477461 acgataggag gaaaacgaat ggccactccg attacgacga tcaaaaaaga aacaaaaaca 2477521 gctgagcaaa ttaagcttga aaaaatagaa gaactgaaag agctgctggc ggaaaatgag 2477581 gacgccgtct ctaaaacgat gacgttaatg aatgaactca atgatcttgg aatttttgat 2477641 gcggcaacaa gcatgctcag agcgaaggaa gacattgcca agattgcgct tggccaagtt 2477701 tcccgcgagc ctgtcaccaa cctcatcaac acgatgatgg ccgccggagg cgcattgaca 2477761 aaagccgatc ctgagtttac agcaaagctt ttagaaagcg taatggctgg gactgaacag 2477821 gcacaaagct ttttaaaaga agacaagaaa gtcgggattc tcgacctgtt aaaagcaatg 2477881 aacgatcctg acatcaacag agccgtcggg ttcggccttc agtttttaaa aggcatggga 2477941 aaagaacttc gagaacaata acagaaaaac agccatctct gatgatggct gtttttttat 2478001 tcgtcggctt cttccagacg cttcttgtaa ataagtgaac ggtcagcgca aaagaaggca 2478061 ccggctaaaa atacgcaatc cgctaaaaac atcgtcgatt tctggcctaa tgttaagcct 2478121 tgatcaggga gaactgcgcc tatatataaa aaagtgctga ctgcaagcaa tgtaaaagca 2478181 aaatgcttgt agtcttcttt taaagatttc attctatttt tgttcaaaag aatcacctgc 2478241 cagattcata gtatacgact attataatat aatccggcgg cttacagaga aagtaattct 2478301 atccatttgt tatatatttt caagcgcttg gccgatatct tccaacaagt cttccgcatc 2478361 ttcaattcct acagaaattc tgatcaagcc gtccgtaatg ccgagctcaa gccggcgttc 2478421 tctcggaata gaggcatgtg tcattcttgc aggaacagaa attaagcttt caaccgcccc 2478481 caggctttca gcaatggtaa acagtttcag atttcctaaa aacgcatcaa cccgttcttc 2478541 actgccaata tcaaaggaga tcatgccgcc gaagcccgct ccttgcgttt ttgcaagctc 2478601 atgtccggga tgatttgaag aaccagggta atataacgtt tggacagcag ggtgattctc 2478661 aagaaagctt gcgattttcc gcgcattttg atcgatcgct tccattctga gtcccaacgt 2478721 tttgattcct ctcattaaca gccaggaatc ttgagggccg agcacgccgc ctgtggagtt 2478781 ttgcacaaaa tgcagctctt ctccaagctc tttcgaagct gtcacaacta aacctccgac 2478841 gacatcactg tgtccgccaa gatattttgt cgcactgtgc agtacgatat cagcgcctaa 2478901 agtaagcggc tgttgaaaat aaggagtatt aaaggtattg tctacgataa gcagaacacc 2478961 cgcttttttt gcgatatcag ccatgagcgt caggtcggtg attttgagca acgggtttgt 2479021 cggtgtttca atataaattg cttttgtatt agggcgaatc gctttttcaa cttcttccct 2479081 gctgctcgta tcaacaaatg ttgattcaat gccaagacgg ttaagcacct ttgtcatcac 2479141 gcgatatgtt ccgccgtaca catcatcagt caacacgaca tgatctccgc tgttaaacag 2479201 catcataacc gctgtaatgg cagccattcc tgagctgaac gcatagcctg cttccccgct 2479261 ttccagttct gtcacaagtg cttcgagagc ggttcgagtc ggattggccg ttcttgaata 2479321 ctcgtagcct gtatgctgcc ctgctttcgg ctgcttgtac gtgcttactt gataaatcgg 2479381 cacggaaact gcgcctgttt tctcatcacc tgtgattccg ccatgtatca tcaatgtttt 2479441 tttcttcata tcagatgcct ccttcgtata tttgtttgct gatatatcga tcgctgctgt 2479501 caggaaatac tgtgacaatg ttagttccag cggatgcttt tttcgcttcc tccaatgccg 2479561 cataaagcgc tgcacctgaa gagcttccga tcagcaggcc ttctttttct gccgcttctt 2479621 tcacaagtct aaacgcattc tcatctgtta cggtgtagat ctcgtcaaaa tggctcttat 2479681 ccatataatc ggggataaac tccatgccga tgccctctgt tttatgagcg tggggctctc 2479741 ctccgtttaa aatcgagccc accggttcaa caatcaccgt tttgactgct ggattttttt 2479801 cttttaagaa ggaagctgtc cctgcgaatg tgcctcctga tcctgcccct gcgacaaatg 2479861 tatgaatatt cccgtcaagc gcttcccaca tttcaggtcc aagcgtctta tagtaagtcg 2479921 atggatttac tcggttttta aattgcaaaa cgcaataaga attttcaatt tcagtctcca 2479981 gctgaatggc tttttgaatg gctccctgca ttccgtcttg acgcggtgta tgaatgattg 2480041 atgcgccaag cgcttgcata atttgctgtt tctctctgct gaaatgttca gggacacaga 2480101 aaatcgcttt cagcccatat tttctggcac ttaacgcaag gccgatccct gtattgcctg 2480161 ccgtagcttc tataatcact ccgccgggtt tcactttgcc tgaatcgagc gcgtcacgaa 2480221 tcagcatatc tcccagtctg tctttgatgc ttccccctgg attcatcatt tcaagcttgg 2480281 catacaccgc gactccttct ggaacatcaa agttcttcaa gcggagaagc ggtgtattcc 2480341 caatcagctc ggtaatgtcc gtaatcactg tcatatatgt cctcctcctt aatagaggtt 2480401 gtttttagag aaaaacggag gagaacgttc tccccgtttt aatgaattcg tttgatcacc 2480461 tttaacacaa gctctgttga atgaacagcc gcctgctcta aaaattggtc aaatgaaaca 2480521 tgtgattctt tgcctgcgat atctgataac gctctgatga cgacaaacgg cgttttaaat 2480581 tgatggcata cttgagccac tgccgcagcc tccatttcaa ccgcgtacag atcagaaaat 2480641 ctcgcacgca cctcttcaac ccgcttcgga tcgttcatga aagaatcgcc tgttgcaatc 2480701 gttccttttg caacctgaat gccgtcgagt tcagataccg cttcttcagt gatgctgatc 2480761 agcttttcat ccgccgcata agcagccgga agacccggca cttggccgta ttcatagtca 2480821 aaagccgtta cgtctacatc atggtggcga acgtcagtgg aaatgacgac atcccctaca 2480881 ttcaatgtat gatgaaatcc gccggctgag cctgtgttaa tgacataatc aggcttgtaa 2480941 cggtcaagca gaagcgtcgt gctgatagca gcatttactt ttccaattcc tgattttaaa 2481001 agaatcactt cagttccttc atattcgcct gttgtaaatt cacagtgtgc gatcgtttct 2481061 gtttttgcat tttcaagttt gtttcttaag atggtaactt cctcttccat tgctccgatg 2481121 actgctagtc tcatctattc acattccctt cactttaccg tttgatcgcc tccattatcc 2481181 acacgaagtc gttttgctga gtgaatcgga ctgcaaaacc ttcagctgta aacatttctt 2481241 tcaacgcatc caatgtagga taatgctctg tctctaaatc atttgcaagc tgataaaagc 2481301 cttgagaacg ggctttatcg atagcctgtt gatacgcttg cgcattttca aagacggtat 2481361 cggcaaacac tattttatca tgcaagtgaa ggtatttgcc atattgcttt atggcagccc 2481421 gcttttcttc gtcagtcaaa tgatgaaaag catatgaact gacaatcgta tcagcctgaa 2481481 atggcggctc agggaatgtc aggaagtctc catcaacgat ttccgtcctg cctgagagct 2481541 tgtcagaagc cagtttacgc attgctggag aaggttcgat tccaaataca gttttgcctg 2481601 catcgagcag cttagctgtc aaattcccgg tccccgggcc aaattctaac acatgcgttc 2481661 cagattttct gacgatggca tcaaggatat gatcgtagcc tctgaacgct tctttatact 2481721 gaatatctaa accttgtact gtttgatcat aagttgctgc ccaatcttca aagagaggga 2481781 taaattcacg gcccatattt gtcacactcc atatttaata attcctataa gtatactatg 2481841 gattaatgat ggaacagttc ctataatacc acatattctg aaaagcaggt actaaaacac 2481901 tttgtgtatt ttatgccatc tcatattgcg cattgaccgc aaaaaagctt atacttcata 2481961 tgacttgtga aagctggagg gtcaagacat gaattttcaa ttagatctga ttaaagacaa 2482021 agtggaattt tttgaagcgg cttcattgca ggagcttgaa aagaaaatca atacacaaat 2482081 tgaaaacaat aaagccatca tgctccgggt gaaatctgtt tcacaccaaa ctcttgtggc 2482141 agaaggaaga atattgtaca gcgcggtggt tcatttctca gctgaagcct aaaacaaaag 2482201 cagccggttt taacccggct gcttttgttt attttagctt ttctactttt gtcggcttcc 2482261 agcctttttc atcgacccat gtaatcgtga cttgatattt attcccagtc gccttgtcca 2482321 aaatcttgcc tttggcatcc tgagggctgc cgttatttcc aagccagagc accgtcatgt 2482381 tatctgttga gacaccagtt gcgtacgaaa tggctttcag catctcagcc cagtcttgtg 2482441 agcttgaatc ataagtagcg gcatgctcgc cagtctgctc agttccgact gctttccagt 2482501 caggattttc atacgttttt tccacatcgc tcgatgagcc gccttctgtt acttttgcat 2482561 ctttaagccc gtcaccggct gaatctgagc ttgaatctga atcagagtca tcttttttag 2482621 aagaagaatc atcttttttg gaatcagagt cagaagactt ctcagaatcc ttttcgctgt 2482681 cagatgtatc tttcttgctg tcttttatat cctcatccga tttcttttcc gtctttcctg 2482741 aagccggaga ttcctgtttt tgcgccgttt cagaatcctt gctgacatct ttgctagaag 2482801 gactgttaat gaagagattc gctgctacta cgacaattag tatggatacg attgcgatta 2482861 aaatgttaag cactaaattg gcttttctgc gtttatcacg attttcataa cgagattgat 2482921 tattgctcaa taattctgca ctcctttatc cctcttggct cagcatatat tttaacatgt 2482981 gctgagaagt tgttctattt ctgattgatt tcaatttcgt gtactttttt aacaatatca 2483041 taaaacaccg aatttgtcag agccttatct cccggtgtat ccatgtgtaa aacaactaga 2483101 gcgtatttcg gcttatccgc gggaaaatat ccggcaaacc atttttcgta gagcgtttcc 2483161 ttctcttttg aaagcttgcc tgtctgggct gtgcccgact tccctgctac agtatacgga 2483221 agatcttgaa accttctgcc cgttccggaa ggagattcta ctacccgccg cagtattttt 2483281 tgaagctgct gtgacgtata tttgtctatc gtttcccctt tgagcttctg atctttaaac 2483341 gtaacgagcg ttgtgccgtt cttatactca atttgttcgg caattttcac ctgccgtttt 2483401 tctccgccgc gggcgattgt cgccatcata ttggctacct ccagcggcgt tacctttaca 2483461 tttttctgcc cgattgctgt ttgcgcaatg gcttttttga ctgatttgtc tttttcatcc 2483521 ccccaaatca cgccgctttt ttcgttatac agctggcgga aatcggtttc gtggtacagt 2483581 tttccctccc agcctgcccg atcagtgaga gccagcttct cggacatatc ttcaataacc 2483641 gagctgtctt ttttcattaa ttgttctgca agactcgtaa atgtgtaatt acagctttgg 2483701 gcaaaacttt catcaaaaga caaggtgcct ttgtcgtccc ccggttcccc gtacaggttt 2483761 aaattgcaat taaaggtttg actaggcttc accatattat tttcgattgc agctgcggca 2483821 atgactgttt taaaaactga tccgggatag attggcgtca gcatataatt ttgaagtgtg 2483881 ttttgccggg acacgtctgc atctggtttg cttacaattc ccagaacact gctattttcg 2483941 atgtccagca gcacagctcc tccctttttc agcccctgtt catccaatac ctcctccatc 2484001 gctttttgaa tgctttgatc gatcgttgtt ttgatctgga gcggataaaa tgtattggct 2484061 tcagctgtat atttgacgtc catgccaaac aaagggtttc cttttccgtc cacatgatat 2484121 aaaagctttg tgtcttgttc cggaagcaaa aactcgtcaa atgtccgttc taaaccggtt 2484181 gttccgattt ctgttgtaat cggaaggctc tccttgtcag gatatttctt gcgaagcagc 2484241 gccggatctt ggttcgtgct ccctatcgta tgtgaagcaa ggctgggctt gtcttcattc 2484301 tccatatata cgccgtaaat gccgggatat ttcaaagaat tgatttttgt gatagattgt 2484361 tttgaaagtg ttttgatttt cttttgctgc aaaatgaccg gtttttttgc ctgacctagt 2484421 gtctggcgca aatcatcttc agacatgccg aggatgtccg caactttttt gatcggccaa 2484481 tcctgcgtca gcagaaaagg gaacaaaaca accgcaggct cgctttgtcc tgtcagcgcc 2484541 cgcccgtttc gatctaaaaa agagcctctt ccatctgaaa tgagcacttc ctccgtccgc 2484601 tgtttcacac tttcttgaat caaattaatt ttctttttag aaaatgattc tgtgaaaaac 2484661 agctggattt ctgcaagtct cagcagaagc agaaaaaata caatcaaaaa agcgatgact 2484721 gccagcttca ttcgtttcga tatcttcata aaaaaacacc tcacccacat tgtggacgag 2484781 gtgtttcgct gctaaacaga tattatgaaa ttttcacaat tttcacgagc atttctccgc 2484841 ccggtgtttg tactgtgact tcttcatcta cttttttgcc caagaggctt tttgcgatcg 2484901 gtgaatcgtt tgagattttc ccttcaaacg ggtcagcttc cgcgcttccg acgatcgtat 2484961 atgattcttc atcaccgtca ggcagttcga cgaaagtgac ggttttaccc aaaccgacaa 2485021 cgttagagcc gccgtcatct tcaatgattt tcgcattgcg aatcatattt tcaagagtcg 2485081 tcacgcggcc ctctacaaat gcctgctctt ctttcgctga atcgtattca gagttctcgg 2485141 aaaggtctcc gaagcttctc gcaattttga ttcgctctac tacttctttt cgtttaaccg 2485201 ttttcaaata ttctaattct tgttcaagtt tttgttttcc ttctgcagtc ataggaaaaa 2485261 ctttctcttg tgccatgtcc cttcactcct tctggttgtc cctcaacatc ttcgattatg 2485321 tatgagagca taaactaaaa aatacaagaa tgagaacaca gggcagtcct cgttcttctc 2485381 tcccatatag gtactgttta tcttaaactg aatcgtgtcg ttctgcaaat atttcgcgtt 2485441 tataaacagg gaaagaaggg aattcgcaca ttcccttcct gcctatacat aatatggtca 2485501 gagttattta tgtctatgct atggtattac aaaatcgcgt tttgttcaag aatggtttga 2485561 atttttgtga ccatcagatc aattgcgacg tgattctgac cgccttccgg gataataata 2485621 tcagcgtatc gtttcgtcgg ctcgacgaat tggttatgca tcggacggac cactgacaca 2485681 tattgttcaa tgacagaatc aatagagcgt ccgcgctcat taatatctct cataatccgt 2485741 ctgatgatac gcaagtcagc gtccgtatca acataaagct tgatatccat cagatcacga 2485801 agccttttgt cttcaagaac aagaatgcct tcaaggataa taacatcctt tggctctacg 2485861 tgaaccgttt cttctgaacg tgtgtgaagc ttatagtcat aaatcggctt ttcaatcggg 2485921 cggtaattca atagatcttg aatatgctcg attaaatagt cattatcaaa cgcaagcgga 2485981 tgatcatagt ttgtgttcag cctttcttca aacggaagat ggctttggtc tttataataa 2486041 aggtcctgct ggatcattaa aattgagtgt cctttaaact gttcataaat ggaccgtgtg 2486101 acactcgttt ttcctgaacc ggaacctcct gcgattccaa tgactactgg attcttaccc 2486161 atgggctgtt acttcccctt tctcatcatg ttgctcggat aaatcttttt gtctagtttg 2486221 aatttgacaa tttgcagggg atggcgggca gcatctagct catttccgtc ttcgtcccaa 2486281 atggtttcaa tcgtatgtgt aaagttttcg atttctggac cgaaaaattc cacttcgtcg 2486341 ccttttttga agaaattgcg ctgctgaagc gtgaccattt gtgtatcttc atcataattc 2486401 agcactaagc cgacaaaatc atatgtcgtt ttcttggcgt gttcgccgaa catttgctct 2486461 tcatagcctg gcgttccttc aaagaaagct gtcgcagtgt ccctgttggc gcacttatca 2486521 agctcttcaa gccattcttt ttgaatcaca aagttttctg gatcagcgca ataagcatcg 2486581 attactttgc ggtatacgct gacaacagtt gctacatagt gaatggattt catgcggcct 2486641 tcaatcttta agctgtcgat ccccatttca atcatttttg gaatggattc aatcagcttc 2486701 aaatctttcg ggctcatcgc aaatggtgca tcttcttcac catacaaagc aacggcgttg 2486761 gcaccgtctg tttggtagag atcataatcc cagcggcatg actggcagca gcctccgcgg 2486821 ttggaatccc gcgctgtcat gtgattgctc agcacgcagc ggccggaata tgcaatacac 2486881 attgcgccat gaatgaagga ttcgatttcg atatctacct tttctttcat ttctctgatt 2486941 tcaagagcgc tagtttcacg tgccagcacg acgcggtcga gaccttcttc cttccagaac 2487001 tggacagcct tccagtttga aagagactgc tgtgtgctca agtgaacctc aacattcggc 2487061 gccactctgc ggcatgtttc aataataagc ggatctgcca caataatacc ggcaacgttg 2487121 gcgtctccaa gcgcttttaa atagtcttca agcccgtcca tgttttcatt atgagcgaaa 2487181 atattcgttg ttacgtagat cttcgcgcca tatttctttg cgaattcaac gccttctgca 2487241 atttcttcga tcgtaaagtt atcggcattc gagcgaagcc cgtattcctg tcccccgata 2487301 aagaccgcgt ccgctccgta atgaacagcg attttcagct tttcaagatt acccgcaggt 2487361 gcgagaagct ccggcttttt cgtaatcaca cgctttccat taacgattgt ggatatttta 2487421 tcatttacgg cagtcatagc ttaacctcct tttgattaat aaaccgtttc cttgaagaag 2487481 aatccggtat caatttttct gtttactggc tggatgcttt caatgcgttc gatccagtct 2487541 tcttttttcg cttcgtattc gtcacggttt tccacgcaca aatcaattgc ttctctgtac 2487601 attttggtga cttctattag gtattcaggc attttcaaaa caccatcgat tttgaaagaa 2487661 tcaattccgg catctatcaa ttcctcgagc tcatcaatga tgcacacatc gttcgggctc 2487721 atgatgtgag tgccgttttc atcttcgaaa atcggatatt tattatcgcg ttctttatcg 2487781 tgtaaaaaca tgcctgattc ttttttcttt ctttcaatgt ccatgacttt gccctgatat 2487841 tcaaaatagt ttccaatcaa agaacgcttc gattggaaca tgcacgtcat tccatgcacc 2487901 tggatttcaa tttcgacttc agcattttct ttaatctcaa caatgctgtc catgtttaat 2487961 tctctggcaa gcacagaacg cgccgcaccc ttgcgtcccc agtagttgca tgtataatag 2488021 ttggtgcctg tcgtttctgt gctccaatga agcttcagat caggcgcaga ttcacgggca 2488081 gccatcagca cggcaggatc gccgaatacc gctgcatcga caccggcttc tgctaagaaa 2488141 gccagatatt cgccaagctc acccacttta tcattatgga aaattgcatt tacagcaacg 2488201 tatacttttg ccccttcttt gtgagcaatc tctacggctt ttgttacatc ttcacgagaa 2488261 aattctccgg ctaatctcaa gccgtatctc tgttccccaa ctaaaaacgc agttgcccca 2488321 gcctgtatga gcggcaaaat gtccgctgta ctcgtcggcg tcactaagag ctctggtttt 2488381 ttcatgacgt tcacctcttc tttttactaa tcgcaagtcc gtccccgaca ggaataatcg 2488441 cagtttgata atccggatga ttcatcagcc aatgattata ttcatcaatt ttggctacaa 2488501 gcctgcgcct tctcttcggt tctattttgc tgtaatcctc tgccaccaga cctttaaaca 2488561 gcacgttgtc tgttataatc accccgtccg gtgaaagcat cggttcatat aaatgaaaaa 2488621 agttttgata ctgacctttt gcagcgtcaa taaaaatgac atcgtaaggc gcggttacat 2488681 gaacggcgtc ggctaattca agcgcatctc cgtaaaaaac atgaatccgg tcatcaagct 2488741 gaaattcctt gatattgttt accgcttctt catgccgttt ctcattgcgt tcaattgtat 2488801 atatttcagc agacggcagt tccagagcca ttcgaatggc tgaataacca atggccgttc 2488861 cgatttctag tatttttttc ggctgtttca cagacaaaat ttgaagcagc acctccatgc 2488921 ccgctttttc cataatcggg acatgatgtt cttctgcata tgcttcaagt ctcttcacgt 2488981 tatccggccg aggctttaat aatgcttcta tatagtcatt tatttgttca taccggtcag 2489041 tcactacaaa cagcctcccg ttctaaaaag gagtgcccca gtcttatgcg caggacactc 2489101 tctgaataca tcatgataca tcggtaaaca acccgatata ttttatcata aaaccttgcg 2489161 gaaagcgaac aaaaggagag ctttttgctc tccttttatt tctcattttt tgaggaaatg 2489221 tatttttctt ttgctttatt atgctctttt agcgtttttg taaatacgac ctcaccattt 2489281 gatttggcca agaaatacag atagtccgtt ttatccggat gcagcgctgc ttcccatgat 2489341 gacatgccgg cattggcaat cggccctggc gtcagccctg tgtttttata cgtattgtat 2489401 ggtgaatcga tttccagatc cttataaaga acccgatctt tatgcttgcc tgccgcgtac 2489461 aggacggtcg gatctgtttg gagcggcatt ttctttttca ggcggttata aaagacgctc 2489521 gcaattttat ggcggtcggc tttttcagtc gcttcttctt ctatcaaaga agccattgtc 2489581 agcagcttat gcacagaaac tttgtttttc ttcatttctg atttatatgt ttccacataa 2489641 gaatttgtct gcttaatcat tgccttgata atgtcttcaa gtgatgtgtc cggatcgtta 2489701 aaagggtatg tagccgggaa taggtaccct tcaagcgggt gcttaatgtt tttattgaaa 2489761 acatcatttg tcacagtgtc cgggaattct ttcttcagct gattgataaa tgtttcatcg 2489821 tccagcttcg ctatgacttg ttttttagag tattttgttt catcagcaat agcagccgcg 2489881 atttgggtca gctgtgctcc ctcagtcact gtgatttgaa aagcgtaacc tgtagccccg 2489941 cttgtcagct tctgaataat ggcatctaaa tccatacctt tattcagatg gtagaatccg 2490001 gcctgaaacc cggaagcacc tttatatttc acatagtact gaaacgcctt ctcgcttttt 2490061 atgacatcat ttttctttaa tatcgatgcg atggctgaaa cagacgaacc gctcggaatg 2490121 ttaatattaa ctgtcgtttt actgtctttt tcaacaggtt caagcaatga tttcccatat 2490181 aaaaatgccc cgccaatgat gagaaacagc acaacaatgg aagacagtat gattcttttt 2490241 ttattaaaaa acgatttttt ttgctgattg atatacatta ggtctcctcc catcagctct 2490301 tatactacat gattcattgt atttcggcaa tttattacaa aaagaggcct gcataaagca 2490361 gaaaaaagcc ggagcagtat agctccggct ttggtttggc gcgatgtttt actcttcgtc 2490421 ttcgtccgct aagaatgtgt ttagtgtttc ttcgatcata tcccattctt cgtcagtttc 2490481 aatcgggaat agctcaccgt tttcaccgtc ttcgtttggc gtgaagctgg aagcaagaat 2490541 ttctacttct tcgtcatctt ttgattcgat tggatagtac aagacataag atttgccaaa 2490601 ctcttcattt tcaaatgtaa acagcacttc acaaagctgt tcatttcctt gatcgtcaac 2490661 aattgtaata tttttttcgc cgtgttccat tttcttcacc tctggcttta atttaagctg 2490721 tcaagatatc cttgtaaaat cataacagcc gccattttat caatgacttt ttttcgtttt 2490781 tgcctgctga cgtcagctgc aatcagcatt ttttcagccg ccattgtggt aagacgctcg 2490841 tcccacagca caacaggaac attgtacgtt gtttcaagca ctttcgcaaa tgtttggctg 2490901 gcttcgcctc tcgggccgac tgttccgttc atgttcttag gaaagccgag cacgatttta 2490961 tctatagtat agtcctttat cagttcagat aaacgggata aaccataatc gccttctgct 2491021 tcatttatct ttatggtctc aatgccttga gcagtccagc ccatttcatc gctcagagct 2491081 acaccgagtg ttttggttcc taaatcgagt cctaatattc tcattcttta tttacgcctc 2491141 tttatgctgt tctaaataag actttaccaa ttcctcgatt aattcgtctc tttcaagttt 2491201 gcgaattaaa ttgcgagcgt cacgatgcct aggaatataa gcgggatcac ctgacagcaa 2491261 gtatccgaca atctggttga ttggattgta gcccttttcc tgaagcgcgt catacactgt 2491321 aatcagcacc tcatttacgt tagtctcagc agaatcatcg gagaaattaa atttcatcgt 2491381 tttatcaaac gagctcaccg ttttgcacct ctttcccaaa ttcgcaggca aagttcagcc 2491441 tggggtccta atcttaccat cattctacac tacatgggcg aattataaaa cggatttcac 2491501 ccaatcttct acagaagcca aagcttcttc taatttttcc ggctgtttac cgcctgcctg 2491561 cgccatgtcc ggacggcctc cgccgcctcc gccgcaaact tccgcagctt gtttaaccag 2491621 cttgccggcg tgaagtcctt tctcaatgag gtcctttgtg actccggcag agatattaac 2491681 tttatcgttt tgtaccgcac caagcacgat caccgcagag ccaagctttg ctttgagttc 2491741 atcgaccata gtgcggagat gattcatgtc ttttgcattt acttttgccg caagcacgtt 2491801 tacgccgtca acttctttta ctttcgacag gattgctcct gcttccacgt tgcctagttt 2491861 tgcaagaaga gattcatttt ctctttgtgc atccttcagt tcagcctgca gagccgcgac 2491921 ccgtttcggc acttctttga tatttgtttt cagctcgtca gcggtctgct tcaatacaga 2491981 aatctggctg ttcatttcga cgtaagcgcc ttgtcccgtt acagcttcaa tccgtcttgt 2492041 gcctgctccg attccggatt cagaaacgat tttaaacaag ccgatttctg ctgtatttct 2492101 gacgtggcag ccgccgcaca gctctaagct gtaatctcca acttgaacga cacggacaat 2492161 atcgccatat ttttcgccga acagtgccat cgcacccatt tcttttgctt cagcgatcgg 2492221 tttcaaatca atgctgaccg ggatgctcgc ccagatcttt tcgtttacga ttctttcaat 2492281 ttgttcgagc tcttcttttg tcacttggcc aaagtgcgag aagtcaaaac gaaggcggtt 2492341 ttccgttaca agagagcccg cctgattgac atgagttcca agaacatctt ttagagcctg 2492401 atgcaataaa tgcgttgccg tgtggttttt aatgacgccg cttctcatat ggtcttcaac 2492461 ttcagccgta acatgcaggc ctttttgaac agtaccgctc tccacaacac cttcatgcac 2492521 atgctggccg ttcggcgctt tttgaacatc tttaattctt acaactgcct gctcgcttcg 2492581 gagatagcct ttgtcgccga tttggccgcc gctttctgca tagaacggtg tttcatcaag 2492641 aatgatttga acgctttctc cttcatgagc ctcttcgatt aattggccgt cctgaagaag 2492701 cacaatgata ttggcatcag ctttggtttg agagtagccg acaaatgtgc tttcaactgt 2492761 cacgtcgcgc agtgcgccgc cctgcacctg catgctgccg acatcctggc gggcgtttct 2492821 tgcccgttca cgctgctggt tcatttcctc ctcaaagccc tcatggtcaa ccgtcatgtt 2492881 ctcgtcttct gcgtattctt cagtcaattc aaccgggaat ccatacgtat catacagttt 2492941 aaacacatca gcacctgaga taacgctgct gcccttgtct ttttcttttt tgatcatttc 2493001 tgacaggatc gcaagccctt cattaagggt ctcatggaag cgttcttcct cggttttaat 2493061 gacttttgcg atgaaatccg ctttctcttt cacttcagga tagaaatcag ccatgatttc 2493121 tgcgacaacc ggcactaaat caaacatgaa cggacgatgg atgttgatcg ttttggcata 2493181 acgcacggca cggcgtaata agcgtcttaa tacatagccg cggccttcat ttgacggcag 2493241 cgcaccgtca ctgacagcaa aggcaaccgt tctgatatgg tcagcaatca ctttaaacgc 2493301 agtgtctttc acattgtctt tgccatatgt ttcaccagaa atcgattctg ttgctttaat 2493361 gatcggaaca aacaaatcgg tgtcaaagtt tgtcggaaca ttctggatga cagacaccat 2493421 tctttcaaga cccatgcctg tatcaatatt tttctttgga agcggtgtgt acgtgccgtc 2493481 agggttatgg ttgaactctg agaacacaag gttccatact tccaggtaac ggtcgttttc 2493541 cccgcctggg taaagctccg gatcttctgg atcattaccg tatgcttcac cgcggtcgta 2493601 aaagatttcc gtattcggtc cgctcggccc ttcaccgata tcccagaagt tcccttccag 2493661 acggataatt ctttcttcag gaataccgat ttttttcgcc caaaactcat atgcctcttc 2493721 atcttcagga tgaaccgtaa cagagagaag ctctttgtcg aagccaatcc acttgtcgct 2493781 cgttaaaaac tcccaagccc atgtaatggc ttcttctttg aaataatcgc cgatggaaaa 2493841 gtttccgagc atttcaaaga aagtgtgatg gcgcgcagtt ttacctacat tttctatatc 2493901 gtttgttctg atcgcttttt gagcgtttac gattcttgga ttttccggca cgacacggcc 2493961 gtcaaaatat tttttcagcg tcgcaacacc gctgttgatc caaagcagtg aaggatcctc 2494021 atgaggcact aatgacgcgc ttggctctac cgcatgtcct ttttctttaa agaaatccaa 2494081 aaacatttga cgcacttccg cagaagttaa gtgtttcatt gtatttcctc ctctataaaa 2494141 atcgaaattc tcttcagtga cagcaaaaaa gccctccccc tatgcaaacc aacgtttaca 2494201 cagggacgag agctgtctcg cggtaccacc ctgattacgg gcattcatgc gcccgtcacc 2494261 tttaaccctg taacgcagga taagcggcag tgattaactg cactcaggat tagcttcctc 2494321 cgatcttctg ataaagctcc tttcagctta tggagcttct ctctttaaca gggcttcggc 2494381 gtactcagat ccgtcactcg agattcgtat gtattctacg agaaattata gacaagcggc 2494441 acgccgatgt caatgctccg tcctcatccg caaaaaatgg atcatcatta cttttaaaac 2494501 agccgtcgca ggaacagcca gaatcatccc gacgataccc gcaagctccc ctccggcaag 2494561 gagtgcaagc atgataacga ccggatgcat tttaaggctt ctgccgacaa tgaacggact 2494621 gaggatattt ccttccataa actgcagaat aaacaccgta atcaccacaa caagaaccgc 2494681 cttgactgag atcgtcatcg caattaacaa cgcaggaaca gctccgatga aagggccaaa 2494741 atacgggatg acattcgtta ccccagagat aaggccaagt atcagcggat acggaagccc 2494801 aaatacccag aacgaaatgc ctgcaatcac gccaagaatc aagcagacca aaagctggcc 2494861 gcggatataa tcgccaagcg aatcatccac atcccgcaaa aaggcgctgc cccgctttct 2494921 ccacgacttc ggagtcaagt accatactgt ctttttcatt aactcaatgt ccttcaccat 2494981 ataaaacacg agaaaaggga ttgttgcagc aattaagaag taatcaagca cattgcggat 2495041 cccgctgatc gcaccctcga tcgttcccgc aaaaaacgcc tccgtctggc ggatcatttt 2495101 atctatacgg tgatgcatac catcaggcca gtcatccgta tggttatgca catgaagaag 2495161 aagcccgtta tacgtttcgg caaacatggg tatattttct gacaaatccg tcagctgcac 2495221 gattaaaaca ggcacccctt tatacaacgc ccagccaatc ccgccaaaaa aaagaacata 2495281 aatgaccaag atgctcaaag tcctaggcaa tcctttgcca tgcagccatt ctgtgaccgg 2495341 aagcaataaa taagatataa aaatagaaat gatcaaggga ataaagatcg tttttatgac 2495401 gagccaaaag ggtgaccata acatatcaag cataaaaaag acatagactg ttaacagaac 2495461 cagcaaacaa atagccaccc acaacaaaag ctgcaccggt ttttggagca tctgctttca 2495521 cctcacctat atcttttgag gtttacaagg aattattctt tatgtttctt tagtcagtca 2495581 gaagtcatgg acattttttc acttttaatt ttcagaaaag tttgatcatt tactttttgg 2495641 tcaaattttc tgataggagg attgcgatga tcacatttca aaatgtaaac aagcattacg 2495701 gagattttca cgtgttaaaa caaattaatc ttcaaatcga aaaaggtgaa gtcgttgtta 2495761 tcatcggccc atccggttcc ggtaaaagca cattgctcag atgcatcaac agacttgagt 2495821 cgatcaatga gggagtgctt acagtaaacg gcaccgccat taacgacaga aaaactgata 2495881 tcaatcaagt gcggcaaaat atcgggatgg tgtttcagca ctttcattta tatccgcata 2495941 aaacagtgct gcagaacatc atgctggctc cggtaaaagt gcttagacaa tcacctgaac 2496001 aagcaaagga aacggcgcgg tactatcttg aaaaagtcgg catcccagac aaggctgacg 2496061 cctatccttc ccagctttcc ggcgggcagc agcagcgtgt tgccatcgca agaggactgg 2496121 cgatgaagcc ggaggtcatg ctgtttgacg agccgacatc agcacttgat cctgaaatga 2496181 tcggtgaggt gctagatgtc atgaaaacac tcgccaaaga aggcatgaca atggttgtcg 2496241 tgacacacga aatggggttt gccaaagaag ttgccgaccg gattgtcttc attgacgaag 2496301 gaaaaatttt agaagaagca gtgccggctg aattttacgc gaacccgaag gaagaacggg 2496361 cccgcttatt cttaagccgt attttaaatc attaaaacag aaatggggga gcttgtatga 2496421 aaaagatttt ttctttagca ttgatttctt tattcgctgt catcttgctt gccgcttgcg 2496481 gcagcaaggg atcaaacgga gaagcctcaa aggagagcaa aaaagatacg ctagccgcca 2496541 ttaaagacaa tgacaaaatt gtcttcggcg taaaaacgga cactcgactg ttcggtctta 2496601 aaaatccaag ctcaggtgag attgagggtt ttgatattga tattgctaaa caaatcgcta 2496661 aagacatttt aggtgatgag aaaaaagctc aatttaaaga ggtcacctca aaaacaagga 2496721 ttcctatgct gcaaaacggg gatatcgacg ccattgtcgc cacaatgacg atcactgaag 2496781 aacgaaaaaa ggaagttgac ttttctgatg tctatttcga ggccgggcaa tcgcttctcg 2496841 tgaaaaaagg cagcaaaatc aagagtgtcg agaatcttgg caaaggctca aaagttcttg 2496901 cagtaaaagg ctccacctcc tctcaaaaca ttcgtgaaaa ggcgcctgaa gcatctgttt 2496961 tagaatttga aaactacgca gaagccttta cagcccttaa atcggggcaa ggcgatgccc 2497021 tcaccacaga taatgcaatt ttatatggaa tggctgatga aaataaaaat tatcaattaa 2497081 caggaaagcc ttttacagat gagccttacg ggatcgccgt gaaaaaaggg caatctgctc 2497141 tcgcgaaaga aatcaacgct tcacttaaaa agatgaagtc ggatggcaga tacgatgaaa 2497201 tttataaaaa atggatcaaa gaagacccag ctgaataaca accatcccgg gatgagcagg 2497261 cgatgctcat cccaatttga taaggagtga ataggcagat gaatgtgtca attcttttcg 2497321 ataacttcag catgtatatg gacggttttt accatacctt gctcgcaagt gttatcgcgc 2497381 tggccggcag ttttgtcctc ggcgttgctg tagcggttat gagaataaca gtctttaagc 2497441 cgctgcaatg gctcgggacc gcatatgtag aattcatccg caacatccct cttcttttaa 2497501 ttacctttgt tttctatttc ggacttccaa acgcaggcct gaggcttgac ggttttcaag 2497561 cgggaacggt tgctctcacc atttatacct ctgcgtttat cgctgaagcc atcagagcag 2497621 gcatccagtc tgtttcaaaa gggcagatgg aagcggcacg ctcgtcaggc tttacctaca 2497681 gccaagccat gctccatatc attttgccgc aggcaatcaa aatcgtcatt ccgcctttag 2497741 gcaatcaatt tttaaactta gtcaaaaact cttcgattct tggggttgtg gccggattgg 2497801 atcttatgta ccaagccgat ttagtttcgt cgagcacact cgttgtattt gatgtttata 2497861 tttttgtggc gcttttttac ttagtgctga cgattccgct tagcatcggt gttaactatc 2497921 tggaaaaacg gctggaaaaa agctattgat aaggagtgag ttacattgga tttcatcggt 2497981 gcttattcac aggagcattt agcgttttta tgggatggct ttctcgtcac cttgtacgtt 2498041 gctttcatct ccatcattct gagctttttc ttcggtttaa tcgcaggcac cctgcgttat 2498101 gcgaaagttc ccgttctttc tcaattgatt gcagttctcg ttgaaacgat cagaaacctc 2498161 cccttgctgt taattatttt ctttacgttt tttgcccttc cggaaattgg gattaagctt 2498221 gaaattacag ctgctgcaat tacagcacta acgatttttg aatccgctat gctatctgaa 2498281 attatccgaa gcggactgaa atcaattgac aaaggacaaa ttgaagcggc gcgctcctcc 2498341 gggctgagct atacacagac cctgttcttt atcgttatgc cgcaagcgct tcgccgcatg 2498401 gttccgccca tcgtaagcca gtttatttct ttattaaaag atacatcgct cgctgttgtg 2498461 atcgccctgc ctgaactgat tcacaacgcg caaattatta acggccaaag cgctgacggc 2498521 agttattttt tcccgatctt tttacttgcg gcccttatgt atttcgcagt caactacagc 2498581 ctttcactcg cagcaagacg cctcgaggtc cggcaaacat agaaaaggat actctttgga 2498641 gagtatcctt tttgcattaa aacattttcg taattcttct tctcatccgc ttcatgcttc 2498701 gattattcag catgtcagat tgagtcgcca ttcggtacac gagagctccg gctcccattg 2498761 ccaaaagaga agtcatcgtc cgattcatcc tgcgcatctc ctttcatgat taaaaattga 2498821 tgctgcgttc atcctcagaa aacaaatcat ccaagctgct taacgttccg tcttcttcca 2498881 cctgatgagt tgcaatcttc cctttcgcca ctgtcagttc aataaaacag ccccagcaat 2498941 aatattggtt cacgccgatt ttgccgatat ccttactttt gcaattcggg catataagca 2499001 tacctcacac ctctatccgt tcagaacgat ctcgtctttc cgcacctcga caagcgaatc 2499061 cgctctttgg atctggcgct tgcttcccgc caggtcagaa aagaaaccgt ccgagagttc 2499121 atatgctacg attatgcccc tgtccaaaca aaagtataca tcttccagca tccccaatat 2499181 atccccctct tgcgatttca caagcttcat cttcatctgc tcgtatgtga agcatgattt 2499241 cggaagaggc aaaagctgtt ctgaactgac cgaagccaat atgcggtcat caaaaatgga 2499301 agagatatca cacgcccgta atagcgcatg atgatgatgc aaaaagcgtt tttgtgcaag 2499361 aataaaccca agacaatctc ctttcagaga aaaacaaata tcggaaattg tcccgagata 2499421 actagaagtt cgttctgagt atactgggaa tccttctact tcatggcatg ttctcaaagt 2499481 gtgatcaacc accttttgtt gaacaggctt aggttttgct ttgcgcctta gactcatacg 2499541 atgaaatcaa ttccactgca aatgaaaaaa aactcccgct tgcacgggag cattttattg 2499601 ctgttcttct ttcataaaat cgaatggtgt aatgccttcc atgccaatgt tggcgtcgtg 2499661 tacgctgaac gggagctctt tttgcaaagc ttcaagctcg gcatccattt cctcaacctg 2499721 tacggacagc ctgtttttca aggaggtctg tctgacagtt gcatcattat ttttcacgcc 2499781 ccactccagc gcctcctctt ccccgcataa aatgagaaat ttcttcgctc ttgtaatcgc 2499841 ggtataaaga aggtttcttc tgagcattct ataatagcct ttcacaacag gcaaaaccac 2499901 aatcggaaat tcacttccct gcgatttatg aatagaacag caatacgcat gggtaaattg 2499961 attaaaatct tttttcgtaa atgtcatttc attgccgtca aaagaaacga cggccatgtc 2500021 ttctttttct gtattttcct ttgcataaaa tatcgacgtg atttcgccaa tatctccgtt 2500081 gaacacattg ttttccggct gattgacaag ctgcaaaatt ttatctccgg ttctgtagac 2500141 aacatccccg aacttcaatt ctctccgttt ttctttagga ggatttaaaa tgtcctgcag 2500201 catcacattc aattcattaa tgccggcttt tcctctgtac atcggagcga ggacctgaat 2500261 gtcctttgct gtatagcctt ttttcaatgc attggcgaca accttctcaa ctacttcttt 2500321 gatttgcgac ccgccgcagc gaataaagga acggtccttt gtcggggcag tcaaattgtt 2500381 cggcagcaat ccatttttca tctggtgggc aagctcgacg attgatgacc cttctgcctg 2500441 gcgatagatg tctgtcagtc tcacagtcgg aatcacctgg gatgccagca ggtctctgag 2500501 cacttgtccc ggaccgacgg aaggcagctg gtcttcgtct ccgacaatga tgatttgtat 2500561 atgatcaggg atcgccttga acaaatgatt cgccagccat atatcaagca tactggcttc 2500621 atcgataatt aacagcttcc cttcgatcgg ctgatcctct gtatgagtaa agccttcagc 2500681 gccgttccag ccaagcagcc tgtgtatcgt aactgcaggg agtcccgttg attcactcat 2500741 ccgttttgct gctctccctg tcggagcggc caaaacaatc ggaaaagctt catccttttt 2500801 ataagctgac gggtctagtg acacaccgtg aagctctccg tagagctcga caatccctct 2500861 gattaccgtc gtttttcctg ttcccgggcc gcctgttaaa agaagcatcg gcgaggaaag 2500921 ggctttttga atcgcttcct tctggctggg ggcatactga acgtccatcc gttcttccag 2500981 ttctcccaac gcgagcaaaa actctgattc gggaaactgg ttctcatatt cggtttggct 2501041 agcgatatgt ttcacacgct ttgcaacgtt ttgttctgcg taaaacagcg aaggaaaata 2501101 acagcggcca tcttctatga caatgtcttt attttctcca agggcaataa ttgcgttagc 2501161 ggcatccatt tctgtaatgc gctgcccttc ccttgctgac tggtttaaca gtgattgagt 2501221 gtcgatgatc agctgttccg tttctatgta cgtgtgcccc tctgacagac aagtcgtttc 2501281 aagcgtgtac aaaatagcag cttttacccg ctcaggatga ttacccgaaa gacccattct 2501341 gctgcccagc tcatccgctt ttccaaaccc gatgccttct acatccttca caagctgata 2501401 aggattttcc tgaatctttt caagcgtctc ggattcatag gcttgataga ttttcataga 2501461 cagctgcggg ccaaagccaa actgattcaa ggaaatcatg atttgctcca gtccctgatg 2501521 ccgctgcaat gcgccagcca gcgtgtctgc tttctttttt gagagtctgg gaacatcata 2501581 aagcactgaa gcatcagcca atattttatt aatggcgctg tcgcccagct ttttcacaat 2501641 ttcttcagct gtttttttgc cgatcccctc gaataaatca ctcgataaat attgaatgat 2501701 gccttcctta gtcgttggaa tctccttttt gaaatgctcc gcctgaaatt ggagcccgaa 2501761 ttttggatgg gttacgatct ttccgtaaaa cgtgtaggtc tcttcttctt gaagcgcagg 2501821 gaagtagccc gtcacggata cggctttatc ttcaatggct tcggaggtct ctgtgacttt 2501881 cactttcaga accgtatata aattggtgtc attatgatag atgactgtgt tgactgtccc 2501941 ttttaaatag ggctcttcct ccagtttaag ctgatccgga tgctgctgca cgagctgtcc 2502001 ctcctcctgt gcctgttatg atggatcaat cagtttttta gcatgaagcg caagcatatg 2502061 atctggctgg atatcgattg ccttgtccag catttccagc gctttttctc ggttttcttt 2502121 ataagcataa gtgacaccgg cattataaaa tgcatctgca tgccccgggt cttgctctgt 2502181 cacagctgcg aattggctga gcgcttcgtc cagcatgccc tcgttggcta agcacatccc 2502241 gaattgaaaa cgcgcttccg tatcgttttc attcagttcg actgctcttt gtaaatatgg 2502301 cagtgcaagc ttaggctgtt cgagcttgac aagtaccgtt ccgagcatgt aaaacaggtc 2502361 gccgttttcc atccccgcac gtagcgcttt ttcaaacatg tctttcgctt ctttgtacat 2502421 ttcttttaca acatagacat ttcctgctcc ataataagca gtggctgcgc tactgtctaa 2502481 ttcaagcgct ttatcataaa acgcaagcgc acgttccagc tcgtttacgg atgaaagaag 2502541 gttggcaaaa ttgatatacg gaatcgcgtc ttctttattt tcttcaatcg cttttgtaaa 2502601 tgcctctgcc gctttctcgt aatcgccttc ctgcatcgcc tctataccga gttgattata 2502661 atccaccgat catcttcctt tcattaaaaa accccaactc agtgttgagg tttttcatct 2502721 tttatacgta ccacaatttt gttccgtctt tgtacacatc atcaattgtc ccgccgccaa 2502781 ggcattcttc gccgtcatag aagacaacgg cttgtcccgg cgttacagcg cggacttgtt 2502841 catcaaagat gacttccgct tcaccttcgc cagtcatgcg cactgttact ttatgatcct 2502901 cttggcggta acggaattta gccgtgcagg aaatctcttc gcccttcatg atatccgaac 2502961 gtacccagct gatatttgtt gctgtgattt tgtcggaata taaaagcggg ttatggaacc 2503021 cttgatctac gtagaggatg ttcttttcaa gatctttgcc taccgcaaac cacggctcgc 2503081 cgcttccgcc gatgccaagg ccgtgacgct gtccgatcgt atagtacatc aacccgtcgt 2503141 ggcggccttt tacttcgccg tccatcgtca tcatatcgcc cggctgtgca gggagatatt 2503201 ggctgagaaa cgttttgaag ttgcgttcgc cgataaagca gatgcctgta ctgtcttttt 2503261 tcgtcgctgt tgcaagttct gcttctttgg caatttcacg cacacggctt ttttgaagtt 2503321 cgccgatcgg gaacatgact ttgctcagcg tatcttctgt cagctgattc aggaagtacg 2503381 tttgatcctt gttttcatca atgccgcgca gcattctgac ttttccgccg cttctgtcta 2503441 ctcttgcata gtggccagtc gctaaatagt cggcgccaag tgacaatgca tgctccaaaa 2503501 aggccttgaa tttaatttct ttgttgcaca atacatccgg gtttggtgtt ctgcctgctt 2503561 tatattcatc aaggaagtat tgaaatacct tctcataata ttgcttttca aagtttacgg 2503621 cataatacgg aattccgatt tggttgcaga cgcggatcac atcttcataa tcctctgtcg 2503681 ccgtgcaaaa accgttttcg tccgtatcat cccagttttt cataaagatt ccgattacat 2503741 catagccctg ttcttttaac agcagggccg ccacagatga gtctactccg ccggacatgc 2503801 cgacgacgac tcttgtatcc tccggccgtt tttccatttc attcactcca attactacgc 2503861 cgccttatta tgtcagccgt ttgacaacgt cggccacatg tttggcagca gttttcactt 2503921 gctcagccgt attgccgagg ccgaagctga ttcgaataga ggacgtcagc cggtcactct 2503981 cttcgccgaa catagcagtc agaacatgtg acggcaggac tgaaccggcc gtgcacgctg 2504041 aaccgctgga gacagcgaca ccagccatat caagattaac cagcagcgct tccactgaca 2504101 caccggggaa ataaagattc agaacatgcg gcagactatg ctctttgtcc ccgttgacct 2504161 cgaatgccac acctgcatct ctaagcgtgt cggcaaagat tgctttaaac gattgatact 2504221 tctcgttttt ttcgtcacgt tcttcacttg acagcttgat cgcttctttc agcccgacaa 2504281 tgcctggaac attttccgtt ccggcacggc gttttctttc ttgctctcct ccgaataaaa 2504341 ggggtgaaag cttcacatct ttactagcat ataaaaagcc tgtccctttt ggcccgttga 2504401 gcttgtgccc ggaaacagac agaaggtcaa tatggctgtt tttcacatca attggcagca 2504461 acccgaatgc ctgaacagca tcggtatgaa aataagcttt gtgttccttt aacagctcac 2504521 cgatttcttc gatcggctgc actgttccga cttcattatt tccatacatc actgtcacaa 2504581 ggattgtatc atcacgcagt gcttctttca cctgttttgc actgactctt ccattttggt 2504641 caacgtccag atacgttatg tcaaatccgt ctccctcaag tttttcacat gtgtgaagca 2504701 cggcgtgatg ctcaattttt gttgtgatga tatgtctgcc aagatctttt cttgcaagtg 2504761 cggttcccat gatcgccaag ttatcagctt ccgttccccc gcttgtaaaa atgatctcct 2504821 gctctgccgc tccgatttct gctgcgatct gcgctcttgc ttcatccacc cattttcgag 2504881 attctctgcc aaatgaatga atactggagg gattaccgaa actgccggag aagtgcggta 2504941 tcatttgttc cagcacgcgc tcatccatcg gagacgttgc ggcatgatct aaataaatcc 2505001 gttccattat gtttacacct ctgatctaaa tatagaacat ataagcttct tgctctccgt 2505061 ctgtatagct ggcaagatcc tctaatgttg tactgtctaa aacctctttt acagcatccc 2505121 ggatgcgaat ccagagctca cgcttggcag gctcctcatc ttccagcact tcaacagggc 2505181 tgatcggccc ctcaagcaca cggataatat ctcccgcagt aatggcatcc ggctcactgc 2505241 ctaatacata tccgccatat gcgcctctga tgcttttcac taaaccggca tttctgagcg 2505301 gcgataccag ctgctccaaa taatgctcgg acaaattatt cgtctgtgcg atgcttttta 2505361 atgaagtcgg gccttcaccg tgcttttttg caagctcgat cataatggtg agcccgtatc 2505421 ttcccttagt tgatattttc aacatgaaca cctctgttat ttcatgattt tccacattta 2505481 taatggtaat ttctatatgt ttcgtccgtt tattatctta tagaccaact gttattataa 2505541 cataccttca gcgaattttc attgaggcag aaggaaaggg gcctttaccc ttttctaatg 2505601 tacggttttc cgttaccctg taattaagta aggagagatg atagatgaag ccattggcat 2505661 atcggatgcg tccgacaaaa atagaggata ttatcggcca gcagcatctg gtggctgaag 2505721 ataaaattat tggcagaatg gtccaggcaa aacatttgtc atccatgatt ttgtacgggc 2505781 cgcccggaat tggaaaaaca tcaatcgcaa cagcaatcgc cggttcaaca agtattgctt 2505841 ttcgaaagct gaatgctgtc attaacaata aaaaagatat ggaaatcgta gctcaggaag 2505901 ccaagatgtc cggccaagtg attttgattc tggatgaagt ccacaggctg gataaaggaa 2505961 aacaggattt tctattaccc tatttagaaa acggaatgat cattttgatc ggagcaacga 2506021 cggctaaccc gtatcatgcc attaatccgg cgatcagaag ccggacccag atttttgagc 2506081 ttgaaccgtt aacacctgaa ctgattaaac aggcactgga acgtgcgctc catgatgagc 2506141 atcggggcct tggcacctat tctgtatcca ttgatgatca ggcgatggag cattttgccc 2506201 acggatgcgg aggagatgtc cgctccgctt taaatgcgct tgagcttgcc gtgttgtcaa 2506261 cgaaggagtc agcagacggt gaaattcaca ttacattaga aaccgcggaa gaatgcttgc 2506321 agaaaaaaag cttttctcac gataaagatg gtgacgcgca ttatgatgta ctgtccgctt 2506381 ttcaaaaatc aatccgcggc tctgatgcca acgctgctct tcactatttg gctagattaa 2506441 ttgaagccgg tgatctggag agcatcgcaa gacgattgct tgttatcgcc tatgaggata 2506501 tcggtttagc aagcccgcaa gccggcccta gagtgctgaa cgctattcag accgctgagc 2506561 gagtcgggtt tcctgaagcg cgaatcccgc tggccaacgc agttattgag ctttgcctct 2506621 caccgaaatc aaactctgcc attctggcaa tcgatgaggc cctggcagat atcagagccg 2506681 gaaaaattgg ggatgtcccg aagcatttaa aagacgcgca ttataaagga gctcaggaat 2506741 taggaagagg aatcgactat aaatacccgc acaattacga caacggttgg gtcgaacaac 2506801 aatacctccc tgatcctctg aaaaataagc aatactataa gccgaaacag actggaaagt 2506861 tcgaatctgc cttaaagcag gtgtacgata aattaatgaa aagaaaataa aacaaaaaaa 2506921 cagccttgat catcaaggct gtttttatgc attatttatc cttcacacgt ttgatttcaa 2506981 tgtctttcaa aagatccatg acaacatgtc cgcccataat caaacctgca actgacggca 2507041 caaaagcatt agaggaaggc ggcatttttg ctttacgtat tttcgcttcg tcattcccca 2507101 cttcttttct gacatcttcc cgaataacaa tcgggctttc atcagagaaa atcacttgaa 2507161 cgcctttttt gataccctcc ttgcgtaatt tcgtacgaac gaccttcgca attggatcag 2507221 tgtgcgtttt tgagatatca gcgatttgga agcgtgtcgg atccgtttta tttgcagcac 2507281 ccatgctgga gatgagcgga atatcccgtt ttagacattc tttcattaaa tgaattttat 2507341 aacaaatggt gtctgacgca tcaatgacat agtcaagacc atagtcaaaa aactgctcat 2507401 acgtttcctc cgtatagaac atttttaacg cgatcacttc acactccggg ttaatgtctg 2507461 cgatccgcgc cttcattaaa tcaactttcg gctgtccgac agttgaaagc agcgcgtgaa 2507521 gctgacgatt tacatttgta atgtcgacat catctttgtc gacaagcaga atgcggccga 2507581 cgcctgaccg cgcgagagct tccgccgcga acgacccgac tcccccgact ccaagcacag 2507641 caactgtgct gtttttcagc gtttcaaggc cttcttttcc gatagctaat tcattgcgtg 2507701 aaaactggtg taacaagaac ctcactccac attcgtattc tggtttcatc tataaaatgg 2507761 ctgatccatg agcagccgtt ttttctgcgc acaaaaaata aagtcccaat agtgccgttg 2507821 cagctttcct ttgttttgaa cccgctctca gcaggtgggt gccctctttt aaatcttgta 2507881 agtcctcttt accgaatgaa aagaggcatg tacgccattt aaaaatgcgg gctcccaaat 2507941 caaaaaaatg ttcggtcaaa actaggtgta caactaacac atcaggactt tatttaactt 2508001 gtcaaaatca tatcacagac gattttgatt ttcaagaatc gaactgcaaa ttcagttctt 2508061 aacttttttc ttgatagaaa gatgaagctc gtcaagctgg gcgtcgctta cttcgcctgg 2508121 cgcttctgtc atcaggcagc ttgcacttgc cgttttcggg aatgcaatcg tatctctcag 2508181 gttcgtacgt ccagcgagaa gcataacgag acggtctaag ccgagtgcga ttccgccgtg 2508241 cggaggagcg ccgtattcaa atgcttccag caggaatccg aactgttcag ccgcttcttc 2508301 tggtgagaag ccgagaagcg caaacatttt ttcctgaata tccttttcga aaatacggat 2508361 tgaaccgccg ccaagctcat agccgtttaa gacgaggtca taagcttgcg ctttcatgtc 2508421 ttcaggcgct gtttcaatca gctcaaggtc ttctcggaca ggcattgtga acggatggtg 2508481 cgctgcgtaa aaacggcctt cttccggatc atgctctaat agcggccagt cgatgaccca 2508541 taagaaattg aacaattttt cgtcaatcag tccgcgttct ttcccaagct ttaagcgcag 2508601 ggcgccgagt gatgcggcca caacttcgaa ttgatccgct ccgaacagca gcaaatcacc 2508661 ttcagcagca tcaagtgctt caatcagctt agactgcttt tcttcatcaa agaatttagc 2508721 gatcgggcct ttcactccgt ctgcctcaac cttcacccag gcaagccctt ttgccccgta 2508781 gtttgcagca aaagcgccaa gagcgtcgat gtcttttctg gagtaatcgc cggcaccgcc 2508841 ttttacattg atggctttga ccacgccgcc gtttgctaca gctgatgaga acactttaaa 2508901 ttccgtatcc tttacaatgt cagacacatc cgtcaaaagc atgtcaaaac gcgtatccgg 2508961 tttatcagac ccgtacttgt tcattgcttc gtcatacgtc attcgaggaa gaggaagctg 2509021 aagttcctca ccttttgttt cacgcataac ctttgccatc atctcctcag ccaatgacat 2509081 aatgtcttcc tggctcataa aggacatttc aatatcaatt tgcgtaaact caggctgacg 2509141 gtccgcacgc aagtcttcat cgcggaaaca gcgggcaatt tgataatatc gttcaatgcc 2509201 tgataccatc agaagctgtt taaatagctg cggagactgc ggcagcgcgt agaactcacc 2509261 ttcgtgcaca cggctcggca ccaagtagtc acgtgcgcct tcaggcgtgc ttcctgttaa 2509321 aatcggcgtt tcaatatcaa gaaacccatt ttcatctaaa aagctgcgaa cagctttcgt 2509381 cacgttatgg cgcagctgca tcgtctggaa catagccggt ctgcgcaaat ctaagtaacg 2509441 gtgttttaaa cgaacgtcct ctgacacttc ttcagcttga tcagaaatcg caaatggagg 2509501 tgtctttgca gcatttaata cgttcactcc atcagcatgt atttcgatcg cgcctgtttt 2509561 caaattcgga ttaactgttc cctcttcacg cgccaccact tttccttgaa tatcaagcac 2509621 gtattcattt ctgatgcctt ccgcaatagc aagcgcttct tttgacacat cagggttaaa 2509681 aacgacttga acaatgcccg tacggtcacg caagtcaata aaaatcaatc cgccgaggtc 2509741 tcgtcttttt tggacccagc ctttcagcgt tacagattcg ccaattgctt tttcagttat 2509801 atcaccgcaa taatatgttc ttccaaacaa tgcgtttcac tccttatccc ttttggtttg 2509861 ccttcatcac atgtataaat tcatcaagtg ccacttcaat ctgttcgccc gtctgtgcat 2509921 cctttacatt gattttgttt tgggcaagct catcttcacc caaaatcgca ataaatctgg 2509981 cctttaagcg atcagctgtt ttaaactggc ctttcatttt cttattttca taatcgattt 2510041 cactggaaat gcctgcttct ctcagtttgt acaccaatga aacagaataa tcctttgctt 2510101 tttcgccgag tgtgacgata tagcagtcga ttcccttatc aacaggcagc tctctttttt 2510161 cagcatcaat tgcggcaagc aagcgttcga tgctcatcgc aaatccgatg cccggtgctt 2510221 caggtccgcc gatctgttcg acaagcccgt cgtagcgtcc gccgccggca agtgtcgtaa 2510281 tcgcgccaaa gccctccgca ttgctcataa tttcaaatgc ggtgtggttg taataatcca 2510341 gccctctcac aaggttcgga tcgatttcat acgaaatgcc aagatcattt aagtattgtt 2510401 tcactttttc aaaataagcg gctgattctt catttaaata tgtcaaaatc gaaggtgccg 2510461 atttcatcag ctcatgatca cggtcttttt tgcagtccaa aattctaagc gggttcgtgt 2510521 gcagccggga ctggcagtct gaacaaaatt cttcgatgcg aggctcgaag tgtttcacga 2510581 gcgcttctct gtagcttttg cggctatctt gatcgccgag actgtttatg acaagcttaa 2510641 cgttttctaa acctgctttt tcataaatac tcatcgcaag cgccattact tcagcgtcga 2510701 ttgcagggtc tttcgaacca atcgcttcaa ttccaaactg ataaaactgg cggtaacggc 2510761 ccgtctgagg acgttcataa cggaacatcg gcccgacata ataaagcttt gtcggctgta 2510821 caggatttgc gaacagcttg ttttcattaa aagcgcgaac cgcagcagct gttccctccg 2510881 gacgaagcgt caggcttctg cctttgcggt cctcgaaggt atacatttct ttttgtacga 2510941 tatccgttga ttctccgacg cctctggcaa acagttctgt atgctcaaaa atcggtgtgc 2511001 ggatttcttt atattgataa gtgcggcaag tgtctctcat aatttgttca acaaactgcc 2511061 agcgatctga ttctccaggc agaatatcct gtgttcctct cggaatgtta tatcccatag 2511121 gtagacctcc ttatgtattc cttataaaat atccaatgat cgttaatgat gaaaatgaaa 2511181 aaaactcccg cccctactat acatgatagt agggacgaga gttatacccg tggtgccacc 2511241 ctagttggaa tacgttcata ttcccgctcg atcctttaac gcaggttcac gttcactgcc 2511301 taatggcgtt attcacgcgt tcagcaggaa acctccggag tgttgtttcg agaaagacgc 2511361 aatgggatcc gctttcagcc tggggcgggt tcctctctaa tcatgcaatc tgacctactc 2511421 ttctccatta ttggttcaaa tctttcatca tttgctatgt actcaatttc tattataata 2511481 atgggattgg ggttctctgt caagctttat tccggttgtt tttcctcagc gctgcttctt 2511541 tggacataag accaaattca gatgctgttt ccgtaagata accagtcgta tcgggatctg 2511601 cgtgatcgct gtaatgcaga ttcgcttcac cgtcgtgaaa tgcacgtccc atttttggat 2511661 gatatttcat gatttgcaca cctttttgat tgtatttacg cttagtataa acaaatcatt 2511721 ttatttttat ttaaaaatca gaaaggactt tacgatatta aacaagaatg cttttttaat 2511781 gatcatcaga aaggaggaca caatgaacaa gaaatacttt gtccttattg tatgtattat 2511841 tttcacctca gcgctattcc cgaccttttc atccgttaca gctgctcaag gagaagcggt 2511901 catcgcaaca gatgaaatga acgtcagaag cggcccaggg cttagctacg gcattacagc 2511961 ggaagtaaaa aagggagaac gctatccaat tttaaaggaa gatggagact gggtgcagat 2512021 acagcttggt tctggagaaa agggctgggt agtctcctgg cttattacaa aggaagacca 2512081 ggccagcaca agctcctcag gaagcagtga cactgtgaca tcaacagacc ccgatctgcg 2512141 gatgagaagc ggcccgggca cttcctacga agtcatcggc aaattcccgc aaggcagcca 2512201 agcatctgtc attgataaag attcgggctg gatcaagata tcctatcaca gtgccaccgg 2512261 atgggtatca tctgaatatg tcacatcagg aggcagcagt tcagcgtctg atgagagtga 2512321 ccaaaccgag gattccggtg cgtcaacgac gggcacagtc ggtgtttctt cgctaaatgt 2512381 aagagcctcc gcctcacatg acgcggcaat tataacaaaa cttgatcgcg gaacgaaact 2512441 gacggttctc aacgagaaaa atggctgggc tcacattgag gtgaacgggc taaaaggctg 2512501 ggttgcaagc cattaccttt tgactagttc tgttccagct gatgattcag caaatgccgg 2512561 cagttcatcc tccgctaaaa aagcctatat catgtacgga ggaacgaatc taagaagtga 2512621 tgcgtcaaca tcagcttcga tcgttgagcg cgctgccaaa ggagattcat acaccattac 2512681 cggttcaaag ggaagctggt atgaaataaa gcttgataac gggcagactg cttatgtagc 2512741 caattgggtg gtccaaacgt ctaaaagcgc agaagaagca ggtgaaccgc cagtctctga 2512801 ttccccgtct ggaaacggct ctctaaacaa taaaacgatt attgttgacc cgggacatgg 2512861 aggaaaagac agcggaacga tcgggtattc ggggaaattc gagaaaaacc tgacgatcaa 2512921 aacggcaaaa ctgctcgcca gcaaacttag atcggctgga gcggatgtat atgtgacacg 2512981 ccaggatgat acctttgtca gcctgcagtc acgggtctct acctctcact accgtaacgc 2513041 tgacgccttt atcagcattc attatgacag ctatgcggat acctctacaa gaggcagtac 2513101 agcatattac tacagtcctg ccaaagatca ggaactcgca tcagatgtcc actcagaagt 2513161 ggtgaagcgt tcttccattc cagaccgcgg cgtattattc ggagattatt atgtgctccg 2513221 ggaaaacaga cagcccgcta tgctgtacga gctgggatat gtaagccatc cgcaggaaga 2513281 agccattgta catagcaatt cataccaaga aaaagtaaca gatgggatcg aaagcggatt 2513341 agagaaatac ttccaataaa aaaagctgcc ttttggcagc tttttttatt ttgaatccat 2513401 aatgagcgtg accggtccgg agtttgtaag ctgaacatcc atcattgctc caaacgttcc 2513461 ggtctccact ttgattcctt tttcacgaag caggtcattc catttttcat aaagacctaa 2513521 agctttatca ggtttggccg cgttcatgta gttcggccgg cgcccttttt tcgtatctcc 2513581 ataaagcgta aactgtgaga cggataaaat ctctcctcct atatctacaa gagacagatt 2513641 cattttccct tcactgtcat cgaaaatacg gagattgaca actttatcgg ctaaataagc 2513701 tgcatcatct tctgtatcat cgtgagtgat gccgaccagc accataaggc cttgtccaat 2513761 ttggccgacg acctcttcgt ccactgtaac gcttgcttct gttactcgct gaacaactaa 2513821 tctcttttct aaccccttta gttcatgacg cggcgcacag aatagatatc tctaatctgt 2513881 ttaatacgct cgacgacttt atgcaagtga ttgatattct ggataaaaat cgccatatgg 2513941 atggttgcca ctttattgcg atccgatttg ccagagacag atgaaatatt ggttttcgtt 2514001 tcattcactg cctggagtac ctcgttcagc aatccgcggc ggtcataccc aagaatctct 2514061 atctcaacat tgtattcctt gcgcttttga acttgtgact catgttccca ctctaccggg 2514121 atcagccgct cttgggcttc attcgttttg acattcggac agtcttcgcg atggaccgaa 2514181 acccctctgc cttttgtgat aaagccgaca atatcatcac ctggcacagg attgcagcat 2514241 tttgataaac ggacaaggag gttgtcaatg cccttgacac gaacgccagc ttcccgtttt 2514301 cttccttgcg ggtatggctt aggttcccca gtgacttcct gaacgatctt ttcctgttct 2514361 tcctggtcgc gctgctttct ctctttttct gttaggcggt tcgccacctg cagagctgtg 2514421 atgccgttgt aaccgaccgc cgcgtacata tcctcttcat ttgagaaatt aaatttgtca 2514481 gcaacctttt gaatattctc cggcgttaaa acatccttca attcaaaatc caagttttta 2514541 atttcttttt cgaccagctc acggcctttt tcgacatttt cttcacgccg ctgtttctta 2514601 aagaattgac ggattttatg cttcgcttgg gatgtttggg caagcttcac ccaatcctgg 2514661 ctcggaccgt aggaatgctt agaggtgaga atttcaacga tatcacctgt ccgaagctta 2514721 tggtcaagcg taaccatttt tccgtttact ttggcaccga ttgttttatt gccgatttca 2514781 gagtgaatcc ggtaagaaaa gtcaatcgga acagaaccgg acggaagctc gattacatct 2514841 ccttttggcg taaagacata caccatgtca gagaacaaat caattttgag cgattccata 2514901 aattcttctg catctgtcga ttcattttga aattctaaaa tttcacggaa ccaagaaagc 2514961 tttttctcaa aggttgcacc ttcattggct gctttccctt ctttataagc ccagtgagcc 2515021 gcaaccccgt attccgctat ttcatgcatt tcaaaggtgc ggatctgcac ttcaagcgga 2515081 tcgcctttag gcccaataac cgttgtatga agcgattgat acatattcgg cttcggcatt 2515141 gcgatataat ctttgaatct gcctggcatc ggtttccagc atgtgtgaat gatgccaagc 2515201 accgcgtagc agtcctttat gctattcaca agaatacgga cagccaacaa atcgtaaatt 2515261 tcattgaatt gcttattttg cagcaccatt tttcgataaa tgctgtaaat atgtttcggg 2515321 cgtcccgaga agtcagcctt gatatttact tcttcgacac gtttcttcac ttcattgaca 2515381 acctcatcga cataaagctc tcgttctgca cgtttcttct tcatgaggtt gacaattctg 2515441 taatattgct gagggttcaa ataacggagc gccgtatctt ccaattccca cttaattttt 2515501 gaaatcccga gacgatgcgc caaaggagca aaaatttcca gcgtttcatt ggagattctc 2515561 cgctgttttt cctgaggcag atgtttcagt gtccgcatat tgtgaagacg atccgccagc 2515621 ttgatcaata tgaccctgat atcttgagcc atagcgacaa acattttgcg atgattttcc 2515681 gcctgctgtt cctcttgaga tttatattta attttgccga gtttcgttac gccgtctaca 2515741 agcattgcca cttcttcgga aaatgcttct ttcaggtcat cgagcgtcac atctgtatct 2515801 tccacgacat cgtgcaaaaa tccgcccgcg attgtggaag ggtccatttc aagatcaacg 2515861 agtatccccg caacctgaat cggatgaata atatatggct cgcccgattt gcggtattgc 2515921 tcgcgatgag catcttcagc gtacagatat gctttttcga caaatgcgat atgctcatca 2515981 gatagatagc tgcgtgcttt atctataact tgctcggcag tcaatacttg ttcgttcgcc 2516041 atggaatcac cttttttaaa atgtaaactg tattgtagtt tattatcaag aaaaaaacga 2516101 aagatgtaaa gagcagaagt tcaaatagcc aaatattata taaaataaat gcaaaacaat 2516161 aggaaaaaag caccctgaca tggagtgctt tttcgttatg cggttatcct tagtatttca 2516221 tcaatgttaa gatgtcgtaa tcttcgagct tatttctgcc gtcaaggtaa gaaagctcga 2516281 ttaagaaagc gataccagca acaacgccgc caagttcttc aacaagtttg attgtcgctt 2516341 caattgtgcc gcctgtcgca agcaggtcat ctgtaataag cacacgctga ccaggcttaa 2516401 tcgcatcttt gtggatcgtt aatacgtctt ttccgtattc caagccataa tccactttga 2516461 ttacttcacg aggcaacttg ccttctttgc ggaccggcgc aaaacctacg ccaagcgcgt 2516521 aagcaacggg acagccgata ataaagccgc gcgcttcagg gccaacgacc aaatcaattt 2516581 gcttttcttt cgcatattca acaatttgat ctgtggcata gcggtataca tcgcctttat 2516641 ccatcagtgt cgtaatatct ttaaattgca cgccctcttt cgggtaatcc ggtacaattg 2516701 ttacgtattg ttttaaatcc atctgtttta tgtcctcctc gtactttcat aagcctctga 2516761 atcttgtttc atcagcttat tcagccattc cttcagctct tcagcagaag aataattcag 2516821 cttttgatcc agttccatca gctgctgttt cgcctgatat gtttgtgagt ctgttaagtc 2516881 gcgtttcttt gctccgctca caacagacag cacaccattc tctattttaa caaaaccgag 2516941 atcaaaaaac acctttgtca tgaaattgat tgtttcaacg gaccagcctt tatgttttgc 2517001 aagctctgaa ccgtgttttt tcacgtcaaa agcgcctctt ttcagcaaga acgcataata 2517061 ccatttaaag tggtctcttg cgggaaaagt tgataaaaag tggtcctcat gattgagaaa 2517121 aataaaatat atccgctcgg gcgcctttcc ttccagcaaa cgtgcgagca tgtccagcga 2517181 aggcggcgga tccagtaata caatatatgc accatcgagg tcaaacgcct ttgcttgatc 2517241 tttagaactg atgacgtgca cttctcggcg aaggtcttca gtttgaagta atgttgttga 2517301 gtcttctttg aaagagacaa tggcccgttt agcagatgga agggcggaaa ctgtgtcttc 2517361 ccacgtccgt tttcccctta aatcaaacag ctgccattca gaaacagcgg catcctttat 2517421 cataagctgc ggcttttttc gattgttcca ttcgttgatt gacatctcac cgacaatgga 2517481 aattcttgaa cccggtacga tgccttcttg aagctcgcct ttattaaaac cgacgcaatc 2517541 aagctgggac gactcgtttc tgatcgtcat tttgacatga gttttatttg cccctatctt 2517601 gcggacatct tccagtactg cattttctac gagaacgtgc ggtttcgggt tcagcatgcc 2517661 aaaaggagac agcatgttca tttctgcgat gctttcaact gtaatgtctt cgacgccgca 2517721 gacaaggtcg acttcctgta cgggaataaa atcctcttcc gtaagcgtat tgtccgctat 2517781 ttcattcagc ctgcttcgca aatccggcac atcttcggct ttcagcgtca tccccgcagc 2517841 cattggatgg ccgccgaaat gaggaagaat atctctgcat tcagaaaggc tctcaaataa 2517901 attaaatcct ctgatgcttc gggccgaacc tttagcgatt cccttttctt catcaatacc 2517961 aagaacaatg gccggtcggt agaaacggtc cacaagcttt gaagccacaa tcccgacgac 2518021 tcccgggttc catccggctt tggccacgac aattgcagtt tgatcgagcc cttgctgttc 2518081 aaccatttca atcgcttcat ccgtcatttt gctgaccatt ttttggcgct ctttgttcag 2518141 ctggtcaatt tctgcggcaa gctcttccgc ttcaaacgaa tcctctgaca taagcaaatg 2518201 aacagcggga tccgcctgtt cgattcttcc gacggcattc agccttggtg cgagctgaaa 2518261 tccgactgtt tcttcgttcg cttctccgat gtctccgcct gacagcttaa tcagctcttt 2518321 taagccgagc cgatttgtcc gtcgaagcct ttcaagtcct agtgttgcta ttaatctgtt 2518381 ttcgtcatgc agcgggacta gatcggcaat ggtgccgata gccgccaggt caagcagttc 2518441 atcaggaagt tcacccaata aagcgtgggc aagcttaaac gcgactccaa ccccggcaag 2518501 ctctttaaac gggtaagtgc agccaggctg cttcgggtgg acgatcgcac ggacatccgg 2518561 aagctccggt cccggttcat gatgatcggt aatgatgaca tccagtccga gttcctttgc 2518621 caccttcgct tcatgcacag cggcaattcc tgtatcaacc gtaatgatca aagagaagcc 2518681 ccgttcttta atcgaacgaa acgcctgttc attaggtcca tatccttctt taaaacggtc 2518741 aggtatataa aaatcaactt gagccgacag tttttgcagc gtgtgaagca tcactgacgt 2518801 acttgtaacc ccatcggcgt cataatcgcc atatatcata atcttttctt gttgtgaaat 2518861 cgcctgtttt attcgatctg ccgcttcttt catgcctttc atttcaaaag gatcataaaa 2518921 atcggcatcc tttgtatgta aaaacagcct agcgctttct gccgtatcaa agcctctttt 2518981 tacaagcagg gacgcaacaa gaggtgttat atgcaattgt tctgtgagtg atttgacctt 2519041 atcctgatct ggtcgctgga tttcccatcg catttttgac gctaacataa attcacccct 2519101 caaccaccct attatactag agcaggctga ggggtttcaa ataatattcg aaaactagtc 2519161 ttttttctca atcatggctg atgcatcctg tgtgtcagtc tgatcagcaa gatgagtatc 2519221 ctcttgttta tgtattgctg ttctattttc tttccgcaag gtttttattt cccgcttcaa 2519281 tttcattacc tgaaaaatgc cgacagaaaa tacgatcagt gctcccatta aaactgagcc 2519341 caaaataaca agaatgagcg gccattctga tcttccaaac aggtaatcaa cttctacgga 2519401 tcgaacatta atgactgcga aaatagcgac aattaaggtg aaaataagtg cgaaaataat 2519461 ggtccattgt ttattcattc tcttttcccc caaacttctt attgaggtaa ctttcccaat 2519521 caagactggt tttaaacatg gcttaacact aggttaagct ccctttgctg ttaatttttc 2519581 ccggatcagc ctcttcagtc cggttccctc accggaaatc acaagtgtat cgccttcgtc 2519641 aatgactgtt tcagagctcg gattcagttg tttatcctga ttctttttaa caattgcaat 2519701 gaccgtcaca tgatattcct gacccacatt caaatcacca atcgtctgat gaatggcagg 2519761 cgctcccgcc tctgctttac accactctat aatcaaatca tcaagggctg actcgacctg 2519821 ttctaatgct ttcggtttat atgccattcc gccaagaatt gcagacattt gccttgcttc 2519881 agcgtcatca aactgcacgg aggcaacaca ttcctcatgg tcgttttcgt caaaatagta 2519941 aagctctctc cgtccgtcat gatgaatgat aattgaaatt ttatcacggt ttctagtaat 2520001 catttcaact ttttgtccta tgcccggcag ctctgattcg cgaaccctca tatataaacc 2520061 ctcctacata tctgaaaacc agccataaac acttttaaca ccatatatat gtttaaatgt 2520121 aagcgtatgt cattatagca aatgtctatt ttaagttcaa tgaaacttca aaaaacaggc 2520181 tgccctgcag aggacagcct gatatttttt attgcgccga atcttttttc agttctcttc 2520241 ctttccatgc aagccaaatt tgtgcggcaa tgtatagaga agaataaacg cctgttaaca 2520301 gcccgaccaa taaagcaatt gagaagttag taatagaaga tgctccaaag atcagcaatg 2520361 tcacaacaac aatcacaacg gttaatacag tgttaattga acgtgtaaag gtttgctgca 2520421 ggctcaggtt tacaatatgg ttcagatcgg caaaggtttt cggcttacgc tttttcatat 2520481 gctcgcggac cctgtcaaat gtaacgattg tatcgttaat ggaatacccg attatcgtca 2520541 agatggccgc gatgaatgta acatctacct caagccttgt aatactgaag aacgtgacga 2520601 taaagaatgc gtcatatagc aatgaggcga tggcagcaat cgccattttg tattcgaatc 2520661 ggattgaaac gtaaataatg atgccaatag aagctatagc aactgcgtac agcgcatttc 2520721 tcgccagctc cttaccgact gtcggtgaaa ctgtgctgac atttggatca gatccgtatt 2520781 tgtctttaaa atacgttttt acttttgcaa tggtttcttt atctggcacc ccgacaaaac 2520841 gggcaacacc gatattgctc ttttcgcctg acagaactac agtatcaggg tccataccca 2520901 gagattcaaa atccttctca acttgctctg tcgtcagctt atggtcgctt tgcacttcaa 2520961 tccgtgcacc gcttgcaaag tcaatgccaa gattcagcct gaacacaagc aggataataa 2521021 tcccggcaac cgtgaccgca ctggagaaaa taaagaagta tttgcgtttg ctcgtgaaat 2521081 cccatttttg gaatggcgta tgcggctctg tattttcatc cgtatcctga atatccatga 2521141 tatgtttctt attgacacca aaccagcctt ttttccgatc aagccatctg ctttccacaa 2521201 ggagagcgag gagaaatctc gataagaaaa cggcagtgat aaagcttgtc aaaatcgata 2521261 ggatcagcat tgtcgcaaac cctttaacag agcttgtccc aaagataaag agcacaaccg 2521321 ctgcaataat ggttgtaata ttcgcgtcaa aaatcgtcgc aaatgaccgt ctgtttcctg 2521381 aacggaaggc agagcggact gactttccta gcttgagctc ttctttaatc cgctcatagg 2521441 taataatgtt ggcgtcaaca gccatcccga cacctaaaat gagagcggca attcccggaa 2521501 gcgtgagtac ggcattcatc cagtcaaaga tctggagtgt aatgtagata taaacagaca 2521561 gcgtaatcac cgcgattaat cccggcagac ggtaatagaa aagcataaat aagaaaataa 2521621 ttgcgatacc gacaataccg gcaaacaccg tatcatggag agcctgctgg ccgaattgcg 2521681 cgcctactga tgtcgaatac ttttcagtca gtttcacagg aagtgcgcct gcgtttaaaa 2521741 tgctggctaa atctttcgct tcttgagctg tgaaatgacc ttcaattttt acatcagttg 2521801 tatttagttc ctgacttaca tttggagcgg atacaaattt aggatgctct ttttgaactt 2521861 ctttcttaaa ggaatcacct ttatcataat ccaaccaaat gacaagctgg ttgtttggcg 2521921 ccattttcat gaccttcttg gtcacttcac caaatttatc agcgtctttc agcttaatcg 2521981 tgacaattgg ctcatttgtt gtgctatcat aagtttgttt agcgccgttt tcgactagat 2522041 cagcaccgtt taacagttcc ttatcatttg catctctgaa agaaagctgc gcttcagtcg 2522101 ccaaaatttc acgcgctctg ttttggtttg tcacgccagc gagctgaacg cgaatccggt 2522161 tattcccttc aatttggatg ttcggttcgc tgacaccgag aacattggcc cggcggttca 2522221 gtgcctctac tgtgctgacc agaacgtctt ttgtgatttt gtcacctttt tttacaggct 2522281 gtacatcata cagcacctca aatccgcctt gcaaatccaa tcctaacgta atattgttag 2522341 cggcaggctt cgtaaagtag cccaagcccg tgccgatcaa tagaacgaaa aggaaaaacg 2522401 caatcaagcg tccttttttc attatgtata tcctccctta aacctgtgcg aatcaacctg 2522461 ctatctcagc agttcttcca atgcttcctg gccctcttca ctgcccagcc aattagacgt 2522521 tttaaatgac tcaacggttg catagttcat aaattcgcca attttcactg ataaaatatc 2522581 actcgccagt tcataaatgc tcagttccgt tttctttttc cacttcttat ctgttaagta 2522641 tgaccacaaa ctttcgagtt caacatcatc atacccgaga atcttaaact cttccagttt 2522701 gctgtaaaga aacggcctga cgtggtcttt atatagatcg gctggatgct tctccacgaa 2522761 ttccacgctc cttttttatt gtttttcaag aagacttgtc atgcttggac gacatatacg 2522821 catatcttta ttgtatatga ttccaggtag tttgagaagg cagggggtaa aaatggcgaa 2522881 acagacgttt ttaaagggca ctcttatcct tatcgcagca ggaatggtta caagaatgct 2522941 cgggtttgtc aaccgggtgg ttatcgcccg ttttatcggt gaagaaggag tcgggcttta 2523001 catgatggca gcgcctactt tcttcttggc cactacatta actcaattcg gtctgccggt 2523061 cgcgatcagc aagctagtcg ctgaagccag tgcgcgcgga gatcatcaaa aaacgaaaaa 2523121 tattttagtc atgtctctga ccattacggg agtgctcagc ctcatcttta caccgctgtt 2523181 tctgtttttc gcccctgtta tggctgaaac gatgctgaca gataagcgaa cactgtatcc 2523241 gctcttggcc attacgcctg ttgtgccgat tattgctata tcgagtgtgc tgaggggata 2523301 ctttcaagga aaacagaata tgaacccgct tgctatgtca caagtccttg aacaggttgt 2523361 ccgcatttca ctcgtggctg tctgcacaac gatttttctc ccttacggaa ttgaatatgc 2523421 tgcagcgggg gcaatgctat cctcagtggc aggggagctg gcatcacttc tttatttatt 2523481 cgtttgcttt aagtataaaa agacaattaa aatcagaaag cattttttac agtcaattaa 2523541 aaacggaaaa caaaccttta cccaattaat gagcgtgtcc cttccaacaa ccgggagccg 2523601 ctttatcgga aacctctctt ggtttttcga gccaatcgtc gtcgctcaaa gccttgccat 2523661 cgccggtgtg gcaacagttg ccgcaacaaa gcaatacggg gaactaaccg gctttgccat 2523721 gacgctgctg actctgccca gctttattac atattctttg tcgaccgcgc ttgttcctgc 2523781 gatcagtgaa ggaatggagc agaaaaaatt gcaggtggtg gaataccgct tagaacaggc 2523841 gatgcgtctc tgtctgctca gcggaggcat ttcagttgtt attttatttg tatttgcgga 2523901 tgagctgatg agagtgatgt acggttcctc aggcgcagct gtatttataa aagtgatggc 2523961 cccgtttttt ctgctttatt atttccaagg cccgcttcaa gctgtgctgc aggcgcttaa 2524021 tttggcagga gctgcgatga tgaacagctt aatcggagcg cttgtcaaaa caggccttat 2524081 ttttgtcctt gccacaaggc cttctcttgg cattatgggc gcggcattag ccattgtgac 2524141 aggcatggtg ctcgtcacgc tattgcacgc agcaaccgta agcaaagtgc tgccgatcag 2524201 catcaaaatc aaggagtacg cgctcagctt cgctgttatt gtaatttgcg gattcatcag 2524261 ctccgccatc aaacaatata taagctttgg agcatctgag gctgtcaatc tagccggatg 2524321 gattgcggcg agcgccgcca tttatatgat cctcctgctc gttttccgtt taattaaaaa 2524381 agatgagctt cgccgcattc ccattatcgg acggttgatc atccgataat ggtcacgtgc 2524441 ggtgcccatc tttttcatca atatatattt ctccgtctgt aaacgagcaa aatgaaatat 2524501 ctgaagggtt tgtgtatccg tgtttttgca aactttcaag cagccatttt ctatctttac 2524561 tgattctgga caggttttct gtttgaatga agccgtctat aatgagcggc atttcgagct 2524621 gccgatgctc tccgctgttt tctttcttaa caatagtcag tttgcccgac ggctctaaaa 2524681 tagcaaatga tacgtcagct actctgtcga tgctattttc tctgagctga accattaaat 2524741 catcaaaatt ataacgctgt gatttcatgg cttcttcgtc aatttttcca tatttgataa 2524801 ttatggtcgg cttaccgtca agaagctggc ggacttttcg gttttttaaa gaaaagtatg 2524861 ccaaagtcac ttgaatgatc attaatacaa gcattggcaa aatggtatga aatagatgat 2524921 cgtctacgtt ttctatggct aaaacggcaa tttcagccat catgataaag acaacgagat 2524981 ctaaaatact aagctctccg atctcccgtt tgcccatgaa acgaaaaatg accaatatca 2525041 caaaatacaa tacgactgtg cgaaacgcaa tagtgagaag ctcttccatt atgcacctcc 2525101 aactcattat aggttgcaac aaaatgatca atttatgtaa gaaaaaccga ttgcatttca 2525161 caaagctttt acgtctaatt catgggataa gggaatacat ttttacaaag acgagccatc 2525221 agcatgtctg acggttttga acaaaaagaa cagaagcctt ttaatacagg cagagaggag 2525281 acaatcatgg aggaaacgaa acaagttgga aaaggcattc tttacggctt aatcgccata 2525341 ttttcagcca tgctcctgac aagtttagcg gtttcacttt tattgaccgc aacctcgctg 2525401 gaagaatcat catttaactg gctgatcacc gctatctcat ttctctcttt atttatcggc 2525461 gggttcattt caggcgggaa aggcaaggaa agaggctgga tgattggcgc attgaccgcc 2525521 ttaagttttt ctctgattat cttattgttt cagtatttag gattcggaaa gacatttaca 2525581 gcagaacagc tgatcttcca tctgggattt ttaggggtgt gcatgctggg cgggattttc 2525641 ggcgtgaaca tgaggggaaa caggtcttcc acataaaaaa gagcgggctc acttgcccgc 2525701 tcttttttgt ttgctatgta tagctcctgc tgttattcag cagcagaaac ttctctgatc 2525761 gcgcggcggt cgaacgtaag acgtgtgtta tcaccagtct taattacgac tttgctttcg 2525821 tcgatagagt caacagtacc gtgcaatccc ccgattgtca ctactgaatc gccttttttc 2525881 agttcctctt gcatttggcg tacagccttt tgctgctttt gctgaggacg aatcagcaag 2525941 aagtaaagga ccgcaaacat taaaataata ggaaccaatg tacctaaagt gccagtcatc 2526001 attttcaccc ctttctgtaa gcctgttatg tttatttaga agcttttcgc atttggcttg 2526061 ttatagccgt aacgctcaaa gaactcttct ctgaaatcac ccagacgatc ctcgcgaata 2526121 gcctgtctta cctgctccat taagtgtaac agaaaatgaa ggttatggta agttgttaat 2526181 cgaaggccga atgtttcatt gcagcgaatc aagtgcctaa tgtacgcgcg agtgtagttt 2526241 ttacatgtat agcaatcaca ctcttcatca atcggacgga agtctctttc aaatttcgca 2526301 tttttcatat tgagtcgtcc ttcagcagta aacactgtgc cgtttcttgc aatccgtgta 2526361 ggcagcacac agtcaaacat atcgaccccg cggatcgctc cgtcgatcag tgcgtccgga 2526421 gaacctactc ccatcagata tctcggttta tccttcggca agagcggtgt tgtgaattcg 2526481 agtacacggt tcatgacatc cttcggttca cctacagaca atccgcctat agcatatccc 2526541 ggaaaatcaa gcgaaatcaa gtccttcgca ctttgtgtcc gcagatcttc atattctccg 2526601 ccttgtacaa taccaaacag cccttgttca tcctgacgat tgtgggcatt caggcagcgt 2526661 tccgcccagc ggcttgtccg ttcaactgac ctcttcatgt agtcgtactc cgccgggtat 2526721 ggcgggcatt cgtcaaacgc catcataata tcagagccga gtgcgttttg gatctccatc 2526781 gctttttccg gagataaaaa cagcttgtct ccatttagat gattgcggaa atggacaccc 2526841 tcttcctcta tattacgaaa cttgcttaaa gaaaagacct gaaaaccgcc tgaatctgtt 2526901 aaaattgcgc ggtcccagtt cataaattta tggagcccgc ccgcttcttt gacaatgtct 2526961 tggcccggac gaagccatag atgataagtg ttgctcaaaa tgatgcctgc atccattgct 2527021 ttcagctctt caggcgacat tgttttgact gtcgccagtg tgccgaccgg cataaaaacc 2527081 ggcgtttcga aggagccgtg aggcgtatgc actttgccca gccgcgctcc tgtttgtttg 2527141 cattctttta taaattcata gcgtattggt tgttcagcca cttttgatga ggcctcctgt 2527201 tctcaaatta tataatcagc atcgcgtctc cgaagctgaa gaaacggtat tcctcttcca 2527261 ctgcatggtt ataggcacgc agaatgtttt ctcttccagc aagcgcgctg accagcataa 2527321 tcaatgacga tttcggcaaa tggaagtttg taatcattcc gtcaatggct ttaaattcat 2527381 agcccggata aataaaaata gatgtccagc cgcttgatgc tttaaattgc ccgtcatgtt 2527441 ctccggcaat cgtctcaagc gtgcgtgtcg aggtcgtgcc gacagaaatg atccgaccgc 2527501 cattttctct tactttgttt aaggctgcag ccgtttcttc tgacatttga taaaactctg 2527561 catgcatatt atgctcttcc acttcatcgg cactcacagg gcgaaacgtt ccaaggccta 2527621 cgtgcagtgt gatgaactca atttgcacgc ctttgtcttt cagctgctgt aagatttctt 2527681 ccgtgaagtg aaggccagct gtaggcgcag cagcagagcc aatttctttt gaatacactg 2527741 tctggtagcg ctctttgtca tcaagctgtt ctttgatata tggagggagc ggcatctctc 2527801 caagggattc aagcacctcg tagaaaatac cgtcatattg aaattccatc tttctgccgc 2527861 cgtgctcaag ctcttccgtg cagattgcct tcaatcttcc gtctccaaat gtgacaacag 2527921 ttcctttttt cacccgtttc gccggtttgg caagtgtttc ccatttatca ccggtttcct 2527981 gtttcaacaa aagaagttcc actttcgcgc cggtatcctc ttttgtgccg aataaccgcg 2528041 caggcagtac ccgggtattg ttcaggacta gacaatcgcc ttcgttaaag aagctgataa 2528101 tgtgtttaaa cgagctgtca gtaagctctc ctgtatgttt atcgagcacc atcagccttg 2528161 aagcatcacg ctgctccaac ggtacttgtg caattaaacg ttctggtagt tcaaaatcaa 2528221 ataaatcgac tttcatgatg atttcacctt tattctagtc ttttgttatt tcattctgcc 2528281 aaaaagatta agcaaaattg ataataccac acttataata atacaagtga caaccgggaa 2528341 gaaaaacgta acatttcctt tttttacaaa aatatctccc ggcatcttgc cgacaaaatg 2528401 caaaactgct ccgataataa gcaaaacagc accaagaatc ataatgatct taggaaattc 2528461 agtcatatcg gggagcctcc atttggaaat gatgataaac ggccggtgtc acgatccttc 2528521 cacgcggcgt tctttgtata aatccaattt gcagcagata tggttcatat acgtcttcaa 2528581 tcgtatgcga ttcctcgccg atggtagctg aaatcgtatc aaggcctact gggccgccgt 2528641 tgaatttttc gatcatgccc atcagcagct tatgatcaat atgatccaaa ccgaggcggt 2528701 caacctgaag ccgctccagc gcattctgag aaatgtcttc cgtaatcctg ctgtcaccca 2528761 gcacttgggc gaaatcgcgc acccttctca gcaggcggtt cgccacgcgg ggcgtccctc 2528821 tcgatcttct tgcaatttca agagccgacg gtttatcaat ctcaacctcg aatacatcag 2528881 cggttcttgt gacaatatcc gccagttctt cttgtgtata gtactcaagg cgagacatta 2528941 cgccgaatct gtctcttaaa ggagccgtca aaagccccac cctcgtcgtg gctcccacca 2529001 gcgtaaaagg cggaaggtcg aggcgaaccg agcgggcaga tgggcctttg ccaatcacaa 2529061 tgtccaggca aaagtcttcc attgcaggat aaagcacctc ttcgatcgat ctgtgcagcc 2529121 tatgtatttc atcaataaat aatacatctc ccggttccag cgccgttaat atagcagcca 2529181 aatcaccagg cctttcaatc gcaggccctg atgtcgtccg caattccact cccatttcat 2529241 tagcaacaat cgaagcaagc gttgtttttc cgagtccggg cggcccgtac agaagaacat 2529301 gatccagcgt ctcctgtctc attttcgccg catctataaa cacgcgcaaa ttttctttta 2529361 ccttatgctg cccgatatac tgtgccagat tttgcggcct caggctttgc tctatcactg 2529421 attcatggtt gtctgcttca cttgagacga gccgttcatc catgaacatc accttacttt 2529481 aatagttttt gtaatgcttt tttcacatat tggtctgttg tcagcccaat ttcttcttta 2529541 aggtgaggaa gcaccttttt gatttctttt tcagcatatc cgagaaccct gagggcttca 2529601 agtgcttctt caagagccgt ttccgctgtt tgcttttcaa gcctttcttc atgattaaac 2529661 agattttcaa tcatttcagg cacaacatct gccagctttc cttttaaatc tagaataatc 2529721 tggcgtgcgg ttttctttcc tactccagga aacttgacca aaaaagcttc atcttcattt 2529781 tcaattgctt ggatgaccgc tccgggatca cccgagccca agatggcaag tgctcctttc 2529841 gggccaattc cggtcacgtt taacagcttt gtaaagagcg ccttctcctc tcttgttgaa 2529901 aaaccataaa gcgaaaaagc atcctctctg atatgatggt atgtaaaaat cgtttcttgg 2529961 cttctctcct tatatataaa cggattcggc gtgaaaatct gatagccgat gccgccgttc 2530021 tctatgacaa tatattgggg agatacataa tcaatcgtcc ctttaacaaa ttcaatcacg 2530081 caaattcacc tctttgactg ttcttcattg taccataaaa acagccaaag tcttatagaa 2530141 aagttaacat atgttcgctt ctctctcatt ctttcacgaa aaaaaagaca tgaatacatg 2530201 tcttcaatca gcggacgcta cccgctgtat gtcttcatat gttcgatgac atcctcaaac 2530261 tccgcttttg tccgaaatgg aatgcctttc agcagatttt tttgcatatg gctttccagc 2530321 ctttctaaat caatttgaaa aaaagactga attggttcgg aagctggctc aggccgccca 2530381 tgaaaagtgg aaatcactcc attatccgat acaccgatat acccgttgac cttgctgagc 2530441 ggagaaatat cgtccatttg cttccggaag agcacatatc cctttttttg ttccactagc 2530501 gtccatccgg cataagctgc ccaaaaatca tccatagaaa acactttttc atgcttatgc 2530561 tcaatgctga catcgccgtc caaatacacc ttttcaagct gcacatgcac ctgcagcggc 2530621 tcatagtgct ccacttccgc gccaagtgcg cgggaaggag ctcctattaa aaatactgcc 2530681 gctgagcaaa gaatgcccag caaaagatac gccgtgctga atcgtttcac cctctacacc 2530741 tctttgcaca cgtttatgat tagtttgacc aaagaggcta ctgcttaacc gttttatcaa 2530801 aatttgtctg cacattttcc ctgacaaacc gttcctccgt atacacatct gtgctttgct 2530861 cagaaattgt caagaatcgc gtcagaaagg cactgaaaaa atacaatgcc gcaaagatcc 2530921 aaatcacgcc acctgcaccg agcggcccaa tgaaaagact cacgatgccc ggcgcgataa 2530981 acgcacataa accagatccc aaattcaaca ctgacatggc agcaccttta ttatcaggtg 2531041 caagcgtcgg caaaagcgcg cttaatggga cgtaccctgc taaagccgcg ccgtagcagc 2531101 aggcgataat catgagcacc caatactgat gcccgatcag ctgaggcgtg taatacagcg 2531161 ccagcgtaaa aataccgcat ccgacaccgc caaaccacat gaccgtattg cgccagccta 2531221 gtttatctcc gactgcaccg aaaatgatat taaacacaat attcacaaaa aacagcgtcc 2531281 cccatatttg cagccattcc gaaaccgaat acccgtatcg tgctaaataa gtaggaagaa 2531341 agatggcaaa tccaaattgt cctatcgcat taatcgtctt gaccactccg ccgatgccta 2531401 ccttagggtt ttcaaacata atcgtaaatg ccttcgacag ttctttccat ttcggctgat 2531461 cttgtttttg tatcggagta aatttatctt tgttaaaaaa taaggcaaga attccgcctg 2531521 ccgccacaaa cagtaaagcg ctccaaagcg tattgatttc tccaaaggcc ggaactgcat 2531581 agctggaata gaacggaccg agcacgttaa ggccgcacgt aaacataaac caaaaccagc 2531641 cgacggcttt tccaagaata ttttgagagg tgctgtatga cacccatacg agaaaagagt 2531701 atgcaaacag cggatatccc aagcctctaa gagcatagct gcccaagaga gccggataat 2531761 acatatgagg aatcgcccag ccgataaaag cggccgaacc gaggataaat gcaagcaatc 2531821 cgacagtcat cgtttttctc ggcccccaag tttggacaaa cgttcctgaa agccaagctg 2531881 agatggtgac agcaatgccg tacatggtaa ataacgatgc ggattgctgc atactgagac 2531941 catgatcaac gagaaaagga gacagccagc cttgttcgag gccgtctcca accataaaga 2532001 tgacaacgcc aatataaccc caaaccatgt gagaaggaat tccgattttg ttcaaaacat 2532061 ttcctttagc atgtactgta ttcattttct ccaccgccta cttaaagtat caatggagta 2532121 tatacccaag cttgctgaat tgtaatcctg ttagattaaa aagcgatttt ttcagtgtgc 2532181 tcaatgctaa caggcatgcc aaaagcaagc gattgctgtg ctgctctggc gatcctcccg 2532241 gcctgtaaac cgtcattgcc ggtgcaggga gtctcctggt ttgtgccgat cgcttctgca 2532301 aaacggagaa tctcctcctc atatgaatcc ttatagcgtt caaggaaaaa gaaatgcggt 2532361 ttatccttca tcacaaaatc agctgttgac acctcaaccg ttgtcggcct gctattgtca 2532421 gccgctgcag agcctttcgt cccgaaaacc tcaacccgct ggtcatatcc gtacacagct 2532481 tggcggctgt tatcaatcac agccatggca ccgttttcaa aagtcagtgt aataacagct 2532541 gtatcaatat cacccagctc cgcaaaagaa ggattcacca aagccgcccc tttggcatac 2532601 acttccgtca cttcgcttcc cataatatat ctggccatat caaaatcatg gatcgacata 2532661 tccataaaca atccgcctga cgtacggaca taatctatat tcgggggttc tgggtcccgg 2532721 gacgtgattt ttaataaatg aggtgtaccg atttcaccat tttcaacaat cgttttgatt 2532781 ttcttaaaat gaggatcaaa gcggcggtta aatccgactt gaagtgttac cccgtgtttc 2532841 cggacagccg caagcgcttc actcgtttcg tccagagaga aactaacggg cttctcacaa 2532901 aatatatgct ttttcgcctc ggctgcttct ttgatcatct gtgcatgtac ggctgtagga 2532961 gagcaaataa aaatagcatc aatatcagga tcatgtaata aatcacgata atcagaggtt 2533021 atgtattcaa tctgatgact gtcggcccag ctttttatac ggctcgcctg aatgtcagag 2533081 attgctttta ttttcatgtg aggaatccgg cttatatttt gaacatgaag tttgccgatg 2533141 cggcctgcac cgataatccc tgtcacaatc tgttttgtca tggcttcttc ccccttgatc 2533201 attcacgaaa gcgctttatt taaaattaat actatcccat ttgtaagcgc ttttcaagaa 2533261 tggaaattaa acgttctatg tctcttttat cacaattcat gcttataagt agccttcttc 2533321 ttcaagacca gatacactag aattaggctc tttttcctga acagtttatg attttcctat 2533381 aaacagctgc ataaaataga gcaaagaagg tgaatgaaat gctgacaaaa gcagaggcac 2533441 tggcccatac cgtcatatac cgcaagaaca gcagatttga taaagtcaaa gagaaatccg 2533501 aggaattaac actaatcggc aagggaagaa gcgcctatgt gtttgcctta acagaaggcg 2533561 gtcgaaaaat ggcgctgaaa gtattttttc cggaatatca agcgacagca gtcaaagaag 2533621 cagcgatcta tgaaaaatta gccgggtccg cattctatcc tgacatttac gaaactggcg 2533681 attcatttat tctcatggaa tatattaaag gtgaaacctt ttataactgt ctgaagaaag 2533741 gcattgcaat cagtgatgac atgattcagc aggttgaaga agcgctttct gacgcccggg 2533801 cagccggact gaacccgtca gatattcatt tgcggaatct gatattgaca gaaaccgggg 2533861 cggtgcgggt gattgatgtt gcgagatttg agcagacaaa aacatgcacg cagtgggacg 2533921 acttaaaatc cgcatatcat gcactctaca aaaaaccgat attccccaaa aagattccgg 2533981 gtttttggct ggagatcatc gcatttttat ataagaaaga ttggtttcaa aagcatttcg 2534041 cacagcggaa aagaaaatat tcttaaatca aaaaggcagc cgcacaagcg gctgccttta 2534101 tcatgtattt tttactttct gacggcagaa atcagtttca tttgttcagg cgacagctta 2534161 attcgatagc ctctcacagt taagtagacc gcttctgggt ccttctcgcc ggaatgacaa 2534221 tacgtttttt ccatttctgt ctcccctcac cctttattgg ctttatttca tcttatcatt 2534281 gctttattga ggtaatttta aagaaatgta aagattatat gaatccgata tatagtaaaa 2534341 tgagagaaaa aaagggagag agtcacatta agaccgaaaa caccttgagc ttagatgcag 2534401 ccagaggtga acttgtaaat gaaaaaacac ttgtcaagag aacaatctac tggaattacc 2534461 cggacagccg cccagcagtg acgtggatca atcacaatac agtgaaaatc ggcaatcaga 2534521 ctttacatct tgatactgat gaaacgtatg attggcgaaa agatgatcat tggatccgtg 2534581 aagaaccgcc gcaggcgtca gtgaggtgat gaaacatgaa taagatgaac ggaacaaatg 2534641 atgaaaagca tttcaatcat tttgtgattg ctttatcctt tatatacggt ttgactgaac 2534701 taggctattt gttgctgaag gattttataa caattgccat aagtttgcct ctgtagaaaa 2534761 acgcagcgta gtcgatacgc cgcgtttttt ctttttccct tcctcttctt attgataatt 2534821 acaggtcata taatgtgaca aatcgattgt agaaatagtt cgattagacc aaaatccttt 2534881 ttatacatgt attcgaattt gaagtgaggg ggaagcttga tggcagattt tgttgctagt 2534941 ttgaatgcgg tcttatggag tacgcccgtc atttatattt tattgggaat tggattcgcc 2535001 ttttcaatta tgacccgttt tttacaagtc cgacatttaa aagaaatgat tgttcagatg 2535061 ttcaaaggca agagctctga agccggcgtt tcatctttcc aagcgttatc gattgcgctg 2535121 tccggccgtg tgggcacagg aaacatcgcg ggagtggcga cagcaattgc attcggcgga 2535181 cccggtgcag tgttctggat gtgggcgatt gcctttatcg gggcggcgag tgcctttgta 2535241 gaatcaacgc ttgctcaaat ttacaaagtg aaacaagacg gtcaatatcg gggcggccct 2535301 gcttattata tagaaaaagg cttaggcatt aagtggtttg ccgtcttatt tgccgctgct 2535361 gcccttattg caatggcctt tctaatgccg ggcgtacagt ccaactccat tgcggctggg 2535421 atccaaaatg cattcggcat ctctcctttc gtcacagggt gcggtctggt tttattatta 2535481 gggttcatta tttttggcgg cgtcaaacga attgccaatg cggcgcaaat gattgttcca 2535541 tttatggcca ttggatatat cctgctgtct ttgattatta ttgtcatgaa tgtgtctgaa 2535601 ttgcctgctg tgatctcatt aatattcaaa agcgccttcg cattggattc cgcttttggc 2535661 ggcttgatcg gtatggcgat ttcctggggc gttaaacgtg gcatttactc aaacgaagcc 2535721 ggccagggaa caggcccgca tccggcagct gctgcagagg tttctcatcc ggtcaagcag 2535781 ggactggttc aggcattttc tgtttatatt gacaccttgt ttgtatgttc cgctacagct 2535841 ttcatgatct tgtttaccgg catgtacaat acccaggctg cagatggttc ctttatcgtt 2535901 caccagctta aaggcgtaga agcaggacct ggtttcacac aagcggcaat tgacagtgtt 2535961 cttcccggat tcggtgcagg ctttgttgcc atcgctttat tcttcttcgc ttttacaaca 2536021 attatggcgt attactacat cgcagaaaca aatatcgcct atttagcacg aggcagagaa 2536081 agcaaatggg cgatgcttgg cttaaaactg attattttag ccgccacgtt ctatggtact 2536141 gtgaaaacag cttcacttgc ttgggcatta ggggatgcag ggcttggcat tatggtatgg 2536201 ctgaacgtca ttgccattgt gctgcttgcc aagccggcgc tccttgcttt aaaggattat 2536261 gagcgccaaa agaagcaggg cttagacccg atctttgatc caaaagcgct gggtatcaaa 2536321 aacgctgatt tctgggagaa agaatacact catgaaagtg aacgtgtctc ctgaacatac 2536381 taaaaccggc ccgatatgac ctcgtgccgg ttttttatga acgatagttt gtatacactt 2536441 cttgaacatc atcgtcatct tcaaggacgt ctattaatgt ttccagcttc tcaacagcct 2536501 gatcatcggc ttctgcatag gtattgggaa gcatggtcac ctccgccgaa gaaattagat 2536561 atttcgattc gagggctgtt ttcacctctt caaaatgctc aggctctgtg aaaacctcat 2536621 ataggtcttc ttcaattcgc agctcttctc ctcctgcttc aagcacatca agcatgagct 2536681 catcttcttc tatttgccgt tcagtacggt ctatcgtaat gaaccccttt cgttcaaata 2536741 aaaaggctac acatccgctt tctcccagac ttccgccatt tttattaaag gctgtccgca 2536801 catttgacgc cgttcggttt ttattatctg ttacgcattc aaccatgacg gcaatccctg 2536861 aagggccgta gccttcatag gtgatttctt catagctgct tccgtcttgg cctcccgcag 2536921 cttttttaat ggcccgatct atattttcat tcggcatatt ggcgcctttt gctttttcga 2536981 tgacaagacg caatgctgaa tttgcttctg gatccgctcc gccttctttc gctgccacat 2537041 agatttcttt tgccagcttc ataaatattt tcccgcgctt tgcatcctgt gcattttttc 2537101 ttttttgaat gtttttccac ttggaatggc ctgccatgtt ttcaccttct tttacatttt 2537161 ctatgtacac tttaatggga aatgttcgct gatgcaaaga aaaaggctgc cgaatatcac 2537221 ttccggcagc ccttccttcc tagcggttgt tcattttatg aagttttctg aacagccctt 2537281 tatctgttga tacttggacg tcacggccat ttgcatagtt gcgcgctgct tttacaacat 2537341 tatctctgtc agactttgtg aactctctgt ggcttttgac tgcgataact actcggtcat 2537401 ccgataccat aacttgtgtg tcattgacgt ttttcacttg tttcacacgg ttggcaattt 2537461 ttgcagccag tcttctgttt tcttggttgt catacccgtt gttcgctgca ttccgattca 2537521 tgtttcggtt attcgtgttg ttatatgttc cgtcagttgc caaaggaaca cgatcgtcag 2537581 cagtaacacg gtcacggtta tttacattcg tggtgtttcg gttaccgtcg ttctgatcct 2537641 ccattaattc agaaacagga ccatcgtggt cgattccgtc tccctgtcta tcggcgtcat 2537701 tttcatttgt ataatatccg attggacggg tattgccgtt attgcgcgta tcattcatag 2537761 cattatcgtt tgctccgcat gctgttaagc cggctgtcat tagaatcagg ctagcgatcg 2537821 tcattttttt acccaatgga aaaacccccc gtggacgaat tgagcatgtt tgctcgcttt 2537881 tatcatgtgc gtatgggggg catgttaagc gtgtcagttc tctccatttg gcagtgatct 2537941 gcttgaaaac aaaaaaagga acgatttaca tcgttccgaa cgatcactca ttttcttctt 2538001 ccggacggcc aaacatttgg tttacagaag gctggttcgt cattggcata gaaactcctg 2538061 ccgaatatgg gtttggattt gggttagctg tgccatatgg catattaggg cttccataag 2538121 ctcccattcc cgaatggcca ggtgcagaga aatatggctg atgatcaccg tcacagccgc 2538181 agtcgtcatg atctttgtat ggcatgtaac catgagccgc agcaggctgg tatgctccca 2538241 ttacttgggg agtgccgtaa taagggccat acggcatatg tccatacgga gatccataag 2538301 ccggagatgc gtattgcggc gcaccgtatg aaccgtaatg tccgtgatgg ctgttttcat 2538361 gatgctggtt ttcataaccc gggtcatact gaggcgatac aaagcctggc tggtatccat 2538421 gcatcggatg cattggataa gcttgtgccg gatagtacgg atagcataat cctgatcctg 2538481 gaagaattgg cgaaacaggc accggacacg gtacgaaatg agccggataa tgataataag 2538541 gctgaacagc cggcatcggc atattcggaa ctgtgtgatg aacgttttcc tcttctatac 2538601 cgcctacctc tggcgccttt ggcatattag gcatattcgg ataatttgca ttttccatat 2538661 tactcatagc ctcctgttgt ggaaattggt cttgcatatg atacatatga tccatatttc 2538721 cgtcatgatg ttttttcggc tcctccggtt taggaggcga ccaaggctgg aaaagctgtt 2538781 tcatatcata ataatcgttc acatcagctt cagggtacac attttcctgc aaattaggca 2538841 tcggcgggac atacggcatg gacttctttt ctttcggctt tgtgtcttct acatcgacaa 2538901 cggatttagg cttctctttc gcatatggat gttcttgctt cacactcccg gccgcaggac 2538961 ttttgcccgc ttttggctct tttctgaccg ggactccttc tgacggcact tttattttca 2539021 ttccaggcat gattaagtct ggattgctaa gctgtgtatt gagttttttc acttcctcaa 2539081 catcgactcc gtacttttca gctattttcc agagcgaatc gcctttttga acgatatgga 2539141 ttttcaacgt tttcccctcc tatgcaaaac gtgaacagtt cagctgtgat tacaatatgt 2539201 ttcttcacaa catatgcctg aacaaaagaa gttatgagta aaggaaggga aaatatttct 2539261 gatctacgtg atcgaaagca ttcgattcag ggcaaggagt gcatcttcct gaatggcttt 2539321 tggcaccttg atgacgcctg aaggttctcc tttttcaatt tgttccagcg accacaacaa 2539381 atgcggcaaa tcaattcggt tcattgtcag gcaagggcac atgtcagggt tgagtgattc 2539441 gatttgttta tctggatgct cgtgaatgat ccgctgaaca agattcattt ctgtcccgat 2539501 tgcccacttg cttcccgccg gagcctggtt gattgtgtcg ataatatatt tcgttgatcc 2539561 gttatcatcg cttagtgtca cgacttcgtg tgaacattcc gggtgcacaa tgatctgaat 2539621 gtcggggtct cgctctctca tatcatggat atttttagtg gtgaatttct cgtgaacaga 2539681 gcaatgccct ttccacaaaa tcactttcac attcgtatgc ccggattcag ctactaattc 2539741 atctttcatc ggatcccaca cagccatatc ttcaagcgca atgcccagat cataagccgt 2539801 atttctccct aaatgctgat caggcaaaaa taaaattctt tttttctgtg taaacgccca 2539861 ttcaagcact tttttcgcat tcgaagaagt tacagttgct ccgccatgct ttccgacgaa 2539921 tgccttgatc tccgcagtgg agttcacata agttaaaggt atgatcgtat ctccaaatat 2539981 atgctgaagc ttcttccatg ccctattggt ctgctgcatg tcagccatgt cagccataga 2540041 acatccagct ctcatatctg gcaggacgac cgtttgctgc tcgcttgtca gcatatcggc 2540101 ggtttctgcc ataaagtgaa cgccgcaaaa tacgatataa tccgcttctt tgtttttttc 2540161 cgctacttgg gccaattgca gggagtcgcc tgtttggtca gcaaattgta tcacttcatc 2540221 cttttgataa tgatggcctg gtataaagag cctgctgccg aactttttct taatggcggc 2540281 aacgcgcgtt tccatatcct ttctcgatag ttctttataa ctttcgggca tcatatcatt 2540341 cgattgtttg atcacatcaa gaattgacat aacagcattc ctccacagat tcatttgata 2540401 acgtaacatc catgctgata tctaaacttt tgacggaatg agtcagaaat cctaatgaaa 2540461 tataattcac acccgtccct ttaaaagcag gcaaagattc taacgtaatc ccgccagagg 2540521 cttcagtttt tatattagcc ggtgtgagct ttgcaaaatg acggaccgta tcaggcggac 2540581 agttgtcaaa cataataaca tccgctccag ctgcaattgc ttcccgcagc tgttcctccg 2540641 tttcaatttc cacctcgata tttaccatgt gccctgcggc ctgacgggct tttttgcacg 2540701 cctctaaaat agagccgcat gctgcgatat gattatcttt aatcatgatg ccgtcataca 2540761 aaccgaatcg atgattatac ccgccgccgg ctctgacagc atatttctcc agcattctga 2540821 gccccggtgt tgtttttctc gtgtcacaaa ttttaatctg ttcatcatcc agacaccgaa 2540881 cagcctctct tgtcattgtc gcaattcctg acagcctctg aataagattt aatacgaccc 2540941 gctctcctga aaggagcgca gctgcgggac cgtgtaactc ggcaatcact tcacctttat 2541001 gcaacatgtc cccatctttt ttgtgtaaaa tgctttgaac attttcgtcc aataacgaaa 2541061 agccttcttt tatgatcgct gctcctgcaa aaataccctc tgactttgca acaatctccg 2541121 cttcacagct ctgttctcca aaaatagact gcgatgtaag atcccctgtc ccaatatcct 2541181 caagaaaaaa gtgattcagt aattttttca gctgtaaatg attcattgtt ccaaatcccc 2541241 tcgttttttc tgatcttcgt tccttttttt gtatggacaa tttgtcttcc ttgccagctc 2541301 acctcagcat gaggaaaatc ggtgcggaag tgagcccctc tgctttcctc ccgcaaaagc 2541361 gcagaaaacg tcatcagctt tgcagtttgc catagatgag aaagttccat ctgccgaatt 2541421 gtgatatcct tcacatttac ttcctgaaaa ggcagcgtat gaagccagat gctaagctca 2541481 atcaaactgc tttgttcccg cagaatagac atgtggcttg tcattttgct ttgcagttca 2541541 tgcccctcta tatccggcac ctcgtagaag acactggttt ctagccctga ttgatattgc 2541601 ctgttataaa ccggtttttg gataatatgc tctgctgccc tttttccaaa taccagcgct 2541661 tccaataaag aattgcttgc aagccggttt gctccatgta aaccggagca tgctgtctcg 2541721 ccaatcgcat aaagccccgg cactgtcgtt tctccccagc gattaactga aacacctccc 2541781 attaagaaat gcattcccgg agcaacagga atttttccgc tgtggatatc aatccctgct 2541841 ttttcacaaa tagcggtgat ggtagggaaa cgcgtttcaa aatcagaaat cgcactgaag 2541901 tctatataaa cgcgatttcc ttttgccatt tcttcgtgaa taacccgtga gacaatatct 2541961 cttggagcca ggtcacctaa aggatgccgt tcagccataa tcctgcggcc gttttcgtct 2542021 actaaacatc cgccttcccc tctgacagct tctgaaacaa gcccgtagga aacaccattt 2542081 ttcacaagca gtgtcgggtg aaactgagta aactccaaat ccgttaattc cgccccggcc 2542141 cggtaagcca gagaaagacc gtcacctgtg acagtgagat cattcgtatg gtgaagaaac 2542201 aggtttccac agccgccggc agccagcaca acttcgtctg cgtgccttac cttgagccgc 2542261 cctttgctgt cttttgtcat gacgccgata catcgtccgt cctctataag caaatctgct 2542321 gccgtttcat tctcgattaa cttgattttg ctgttgatcc gtttgagcaa ataatcgata 2542381 agcagcctgc ctgttgcgtc tccgcctgca tgaaatatgc ggttgtatga gtgggcccct 2542441 tctcttccaa gacaaacacc gcctcgttca ttgcggtcga atggaaatcc acgctccaat 2542501 aggctttgaa ccatcatttt tccatcatgt aatacgtctg ctacaatagc tagattatta 2542561 tggccgcacc ctgcgtataa cgtatcctcc agatgggctt caatcgagtc atcttttgca 2542621 taggccgcag caatcccgcc ttgtgcatag acagaattgc tgtttttgac gctttttttt 2542681 gtgataacag tcacttcgta tgagggcggg aaagctgcag ctaaggaaag tgccgccgcc 2542741 cctgaaccga tgactgcaat cgtcttttta gacatatgcc atcctcctgt tgtttacacc 2542801 tgtcttgaca cctatattta cacaaggata aaataaactc aagagttttt tatggagaac 2542861 ggatggagga agaccggatg atttatttag attatgcagc gacaacgcct atttgtgagg 2542921 aagcccttac tgtatatcag aagcttagta tggatatgta cggaaatgcc agcagcctgc 2542981 atgatgcagg aggaaaagca aagcacatac tggagtactg ccgtgaaaaa atcgccaaca 2543041 tcattggcgg agaagcaagc ggcatctatt ttacaagcgg cggcactgaa tccaattttc 2543101 tggccattca atcattgtta aacggcctgc caaaaacgaa aagacatttt attacgactg 2543161 ccatggagca tcagtccatt cataattgcg ctgctttttt ggaacagcag ggatatgatg 2543221 taacagtcat tgaaccgaat gaatacgggc ttattaccga ggaaatatta ctaacccata 2543281 tccggccgga aacaggcctt gtatctattc agcatgcaaa ttctgaaacc gggatcattc 2543341 agcccattca acacctgtct tcatacctgc acaataaggg gattcttctt cattgcgacg 2543401 ctgttcaaac gtttggaaag atcccgatca atacaaaaaa tctgggagta gatgcactct 2543461 caatgtccag ccataaaatc cacggtccta aaggagtagg ggcggtctat atccggccgg 2543521 atgtcccttg gaaacccgtt tatcctctga ctactcacga atacggattc agagccggca 2543581 ccgtaaatgt tcccgggatc ggtgccttca ctgccgctgc agaattgatc gtaagcgaaa 2543641 tggaaaaaca gatatcccgc aatgaggcat taagaacata ctttctagac caaatccgta 2543701 ttcggtctct ccctgtaacc cttgcagcag acacttcgaa agcagaatgt cttccgcata 2543761 ttatagggtg tttttttcac tcatttgaag gacaatatgt tatgttagaa tgtaatcgga 2543821 gtaatatttg catttcaacc ggcagcgctt gttctgcagg ttaccacggt ccgtctgaaa 2543881 caatgaaagc attaagaaaa accgaacaag aagctctgca atttatccgc atctcttttg 2543941 gcaggcatac aacagctgaa cagctggaac agttattaca tacgtttaca gtgctttggg 2544001 aacaaaagaa aggagaattt gatattgacc gaagaattaa agctaatggg cgccaacagg 2544061 cgtgaccagc ttcttctgtg gctgaaggaa tctaaatcac cgctgacagg aggagaactc 2544121 gcaaaaaaag cgaacgtctc aagacaggtt attgtacagg atatatcgct cttgaaagcg 2544181 aaaaatgtac cgattatcgc cacaagccaa ggatatgtat acatggatgc agccgctcag 2544241 cagcaccagc aggcagaaag aatcatagca tgtctgcacg gtcctgaacg gacagaagag 2544301 gaactgcagc tcatcgtcga cgaaggcgtt acagtaaaag acgtaaaaat cgagcatccc 2544361 gtatacggag atttaactgc agccatccaa gtaggcaccc ggaaagaagt tagccatttc 2544421 atcaaaaaaa tcaattctac gaatgctgcc tacttatcac agctgaccga cggcgtgcac 2544481 ctgcatacac tgacagcacc tgatgaacat cgcatcgatc aagcctgcca agccctcgaa 2544541 gaagccggca ttttaattaa agactaaaaa aagccctcta gtgggctttt tttataattg 2544601 gtaagactgg tatgcaccca gaagcctcac tttgcagccg agtgcttcaa gctcctgcat 2544661 ggcccctgga atcaatacat catcaaacgc tttctcaata tcaataataa agaaataatg 2544721 gcctaatccg gttttagtcg gacgtgactc aatttttgac aggtttaaat ttctccaaga 2544781 aaatgcagac agcactctat gcagcgcccc ggactgatca tcctgcggca gcatgaccat 2544841 taaggtcgtt ttgggcctag agctcaattt tgaattcact tcaaaagata tgttttcatc 2544901 gggagacagg ataacaaatc ttgtatgatt gtccctataa tcctgtatat cccgtttcac 2544961 gatttttaat tcgtatgtag aagctgccat atcattggca atgaccccga tattcagctc 2545021 gggatggtca ctgacaaact ttgctgccgc cccggtagaa ttggcgtatt catatggaac 2545081 ggaaggaaaa tgtcgatgaa gaaatttatg gcattgcgca atcgcgtgtg aatgtgagta 2545141 aattttgtcg agctctttcc atgcattctc tcttgaggga tggacgagca agtgctggtg 2545201 aatcggcaac gtcatttcac ccacgattgg caaaggctgt tcatgtatta aatagtctat 2545261 tgttagatta acagatcctt ctaaagcatt ttccaaagga acaaaagcaa aatcaacttc 2545321 gcctgcaacg gctgcatcta tacactccgg aatggtgcgg taagcaacat gttcggcgcc 2545381 gttttgaaaa caagaactga ctgctagatg tgtaaatgta gctgctggac ctaaataacc 2545441 gactttcatg acgattttct ctcccttatg cacctgaacc taatatttca accttttcta 2545501 caaaatcaaa cttcctgagc ttattcatta atgtatgaat gtcttcttcc attgccgacg 2545561 tactgataga cagtgtcaca tttgctctgc cttgaagcgg aatggtctgg tgaatggaaa 2545621 gaacgttgct tccagaatca gctaccgcct gaagaagctg agataacgca cctgacctat 2545681 cctccaaatg aaagaaaagt gtgataattt gttcttttac catggtgtag aatggaaaaa 2545741 cagcatccct gtatttataa aacgcacttc tacttaaatc gaccttttga acggcatctg 2545801 ctactgaatc tgcttttttt cgatcaagca gctttttgac ttctaatgtt tttctcattg 2545861 catcgggcaa tacatcttca cggacaagat aaaatgtctc ctctttcatt tgcatccccc 2545921 ctttaaaata gagagcctgg caccaggctc tcttttcagc caacattgat taatcaataa 2545981 attcaaattc aaattccaga agcctgatta tatctccatc cttggctccg cgttctctga 2546041 gtgcttcatc aacacccatt ccgcgcatct gtcttgcaaa ccgtttaacc gattcatcac 2546101 gtgagaaatc agtcatcttg aataaccgct caaggctgtc tcctgaaagc acaaatacac 2546161 cgtctggatc gcgtgtaatg ttaaatggca cttcttcatt ttccatcgtg tacatgacac 2546221 ggttttgtgt aagctcttcc tcgtcataca gcgggaattc cggtgtgttc tcaagctgat 2546281 tggcaacctc aaacagaagc tcacgcagac cttctcttgt caccgcactg atcgggaata 2546341 ccggataatc atccgtcagc ttttctttaa aggcttcgag attttccgca gcctccggca 2546401 tgtccatttt atttgcaacg ataatttgcg gacgctcagt gagacgcaga ttgtactcgc 2546461 tcagctcctg gttaatcgta agataatcat catatggatc acggccttct aagcctgaca 2546521 tgtcaatgac atgaacaata accctcgtcc gttcaatatg gcgcaaaaac tggtggccca 2546581 gtccgacgcc ttggtgtgcg ccttcaatca gccctggcaa atcagccatg acaaagctgc 2546641 gtccgtcatc cgtttcaacc atgccgagat tcgggacaag cgttgtaaag tgatagtccg 2546701 caattttcgg ttttgcagat gagacaacag acagcaaagt agattttccc acactcggga 2546761 acccgacaag tccgacatct gcaagcactt ttaattcaag aacaatgtag cgttcttttc 2546821 ccggctcgcc gttttctgaa agctgaggcg cgggattagc cggtgtagca aagcggctat 2546881 ttcctcttcc gcctcttccg cctcttgcaa tgacagcccg ctgtccgtgc tctgttaaat 2546941 cagcgatgac ctgttttgta tcatcgtctg tcacaacggt gcccggcgga actttaatga 2547001 ccatatcatc agcatttcgc ccgtgctggt ttttggacat gccatgctcg ccgcgaatcg 2547061 ctttaaagtg ttttttgtat ctaaaatcca tcagggtgcg gagaccttca tctacttcaa 2547121 aaacgacgtc tcctcccttt cctccgtcac cgccggcagg gccgcctttc ggcacatatt 2547181 tttcacggcg aaacgcaacc ataccgttgc cgccgtcgcc gccttttaca tatactttga 2547241 cctgatctac aaacataatg tcctccgttc taaaccgtta aaaactccgc tagtccaacc 2547301 caatttcaat cagacattcg tgactcgtga tttcaaaacg catgatatca acgtcctcat 2547361 atccattctg ccgaatatca tcaaaagcag atggatcggc aaaggcgccg tgaaaatcaa 2547421 ggtacagaat cagctgtctg tcaggatgat ccgtttgaag cgaaaccgtt aaatgatttt 2547481 cactctctct gctgactgct tgatcaaaca gatgaaacag ctttctcatc agtttcgcca 2547541 gcttttgatc ataagccgac aaatccttaa tttctccgag aacttcatat tcaagcgtca 2547601 tataatgggt tttccaatta aacgtaagaa aatcaaacgc caaatgcggt gttttcaggt 2547661 ttgagagctt tgattcgtgc tttgcgtcta taaccatttc ttcaatcatt tcaaagacac 2547721 ggtcatactt ctgtaagctt aagtttcctt taatcagctg cagcttattc atccaatcat 2547781 gccgggaatg gccaagcaga tgaatcagtt cgtttgttaa tgccgtgtcg cttatatttt 2547841 cttcttgatt ttttgaaaca tccttcattt tcgcactccc aatcatttaa tttcttattt 2547901 aggagtctgt ataagtgtgt attatgaatt ataacagaga aggctttgtt agaaaaacaa 2547961 ttgtttttcc cagaaatatc atgttccttt tttctggctt tggttgattt gcagccaggc 2548021 agaacatttt atgtattact gcttggggaa catatccagt gggtttgaga tgtttattct 2548081 cattcttggc ggggtctgct cgcacatact ctgcatttca ttctaggtgt ttactccgca 2548141 tattgcaaaa aaaactccag tcatcatcga ccggagtttt ttgaatcatt attgagctac 2548201 aggatatacg ctcacttttt tgcggtcacg gccgaaacgt tcgaatttaa cagttccgtc 2548261 gattttcgca aatagagtgt catctccgcc gcggcccacg ttttcacctg ggtaaatttt 2548321 tgttccgcgt tgacggtaaa ggatagaacc gcctgttacg aattgaccgt cagcacgttt 2548381 agcacctaaa cgtttagcct cagagtcacg tccgttcttt gtagaaccta ctcctttttt 2548441 agaagcgaaa aactgaagat ctaatctaag catgtagctc acctcctata ttatgtttgt 2548501 ggtcacacgc aagttgtctt tgtaatcccg ttcgattgtc tccagcgaaa caatcatgcc 2548561 ttcaatcagc agctgagctt tttggcgtgc ctctggatca agagattcag ggaattcaaa 2548621 ataaaaataa cccccgtcct ctcctatatc aagaagcggc tcgaagcccg cgagcacaat 2548681 gaccgcgtta acggccccaa acacaacggc tgtcactccg gcacaaacaa gatcttgtcc 2548741 atgttcagca aaattcgcat ggcccgtcat ttcaaaagac aatatgcctt tatcatgaga 2548801 ccttctgatt gttgcctgaa tcatgcttac gcgttgattt tttcgatcgt cactttagtg 2548861 taaggctgac gatgaccttg ttttttatga acgtttttct ttggtttgta tctgaaaaca 2548921 gtgatttttt tcgcgcggcc ttgtttttca actttagccg ttactgttgc gccttcaact 2548981 gtagggttgc cgactttcac gttgtctccg ccaacaaaca aaacgtcttc aaaagtaact 2549041 gtttcacctg cttcagcagc aagtttttcg atgtaaacag tttggccttc ttcaactttg 2549101 atttgtttac cgcctgtttt aatgattgcg tacattctct gcacctccta ttagactaag 2549161 actcgccaga taccaggggg ctgtaaaagc tcttaacacc tgtactgagc ggttgtagca 2549221 atggtgctac atccataaca ttaaaaaata taccaaaata caaggcgttt gtcaatcagt 2549281 tttagtaggg cagaagcagt tcctccatgg aagaattcgt ccgcttatcg gcaaagtaag 2549341 cgtgcagcac ttcattctcg tcaagctggc tgagcttttg gcctgatttt tctataataa 2549401 tcggatgctt acagccacgt ttgaactcgg ccatcacatg atagacttta tcctccgcct 2549461 ttactgtcag cggcagaagt ttctcaagct ccctgttttt tccgtaatac ctttcgagga 2549521 gaaatctcac atggatatag tgcctttgcc gatattcctc aaacaaggaa acagccagaa 2549581 agacaaacaa aacccatgcg ctgatttgca gaggaatcac gaataaaacc cagcacccga 2549641 gcagcaggca gaagcagagc gacgttttta gattaagccg gtgagccttt tgaaaaggca 2549701 gctgtttgga aaacaacaaa aataacagtt ttcctccatc cagcggccag atcggcagta 2549761 aattgacaaa taagatagaa agattataaa aggtgaagag ttcaaaggta tgctgatgaa 2549821 tcactgagac ttctgcaagc atccaggcgg caaactgaag ccagatgtgc tgaagaggtc 2549881 cggcaataat gaccgcaaac tcttccttta acggccgatt cccgtgctct tccacttcga 2549941 ccgttccgcc aaacggcagc aaaaaaacac gcttgattct ccaagaaaaa aacacagcca 2550001 gagcagcatg ccccagctca tgaatcaata caatcaggag cagacataat aatgctttca 2550061 tatggcctgt gagcaagccc agcgccgcaa taatccaaag aaaaggatgc acatggatct 2550121 ttaagataag gtcgagccat ttattcaaat gaaatcacct gaatcggatc aataaattta 2550181 tcgccgtctt tcatggcaaa ataatagacc cctttattat gatcatcaag cttaatcgaa 2550241 ccgagctttt tgcctttatc cacaaaatca tataaagcaa catccacatc tttgagctcg 2550301 ccatagatac tataggtgtt gtcagcatgc tgcaccttaa ccgtcagtcc cgtttggctg 2550361 tctttgctga cttcaaccac atagccttct tttacgctat caatcttatc actgcttgtt 2550421 tcgactttaa ttccttcccc attgtcctga aaatcctgct gtactttccc ggatgcaggc 2550481 gcgatcagat ctttgcctac ttcaatctgc tgttccttat ttttgtgttc aggagccagg 2550541 aaagcaagcg gatttccgaa tttggtttcg aaccaatggc ttgctgaagc aaattgaaat 2550601 tcagtttcaa aggttttggc tacggcgggt ttaatctgac tgacgggtcc aatgtttgtt 2550661 ttataggcta tagctgaaac gagaacaagg caggccgaca gaagacattt caggataatt 2550721 gaatctgttt tcaccaatgg gtgttttccg ttgaatgttg gcatgttatc ttcgtagacc 2550781 ggaagtgttc catgcttttc ctgatccgtt accatcaccc aggacggggg tttctgcttt 2550841 tcagaaactg tctgagtaga gaaacgtttt gagccggaaa gctgctttct tcttttctct 2550901 aatcgttttc tgatttcatc tgctctgtga ctcattgcca tcatcctttg cattcgttgg 2550961 gtttgtacat catatgtctt gtccatggca aatattcggt ttagtcaaga acaaagcagg 2551021 caaaaacaaa aaaaacctga cacagcatat gctttgtcag attcttctct ttgattctat 2551081 cacattaaga tcttactccg aaaaatgact taatcttagc catcattcct ttgttttgct 2551141 cttcaagcac ctgtaaagga acagattcac ctaagatgcg gcgggcaata ttgcgatatg 2551201 caatggaagc gcggttttta gggtccatcg caatcggttc gccatgattg gaagctttaa 2551261 tgacttcatc atcatcagcc acgattccga gcaaatcgat cgacagatgc tgtacgattt 2551321 cgtcgatatc catcgtgtca ccgtttttca tcaggtgatt tctgattctg ttaacaacga 2551381 gccgcggcgg ttcaatattt tcctcttgct ccagcagtcc tataatacgg tcagcatcac 2551441 gaacagctga gatttcaggc gtagtgacca caatcgcttt atcagctccg gaaacggcat 2551501 ttttgtaccc ttgctcgatt ccggcaggac agtctatgat gacatagtca aattcctgtt 2551561 tgagctcttg gaccatgttt ttaatttgtt caggagcaac agctgtctta tcgctcgttt 2551621 gagcagcggg cattaaatag agcagatcat cgaaacgttt gtcttttacg agcgcctgat 2551681 gcattttgca tctgccctct acaacgtcta ccagatcgta aataattcta ttttcaagac 2551741 ccattacaac atcaaggttg cgcagtccta tatcagtatc tactaagcat acgcgcttcc 2551801 ctaaaatggc taaggcggta ccgaggttcg cagatgttgt tgtcttacct actccgcctt 2551861 ttcccgaagt tattacgata gcctcaccca attcacattc ctccctcaag ccttgttaga 2551921 tcaggtctta aatgagccaa atgttgaagg cgttcaatga ccatatttcc gtctgtatct 2551981 aaataagcac attccatttc gttccctttt tgaatgtggt ctggggagcg atttaacaca 2552041 tgattgattc ttaattgtgt cggaagcatt tcagaggcgg cgatgaccgc ttgattattt 2552101 ccattgaatc cagcatgcgc aattcctttc agtgagccca gaacaaaaat gttccctccg 2552161 gccctgactg ttccgccggg attcacgtca ccgatcagga gcaagtcgcc ttttacctgc 2552221 agcacttggc ctgaacggac aatttttgaa acagaaataa tttcggcttc ctctcttatc 2552281 tgctgtgctt cttttttagt aatgacttca ctgtcaatag aatgaacaaa caaatctttc 2552341 tttgacgcaa tcaattcggt tagctgttcc tcttgctcct tatataaaaa gcgatttccc 2552401 agcttaacat gaacgctgat tttctggcct tttccatcgg tatattgttc aattgacagc 2552461 atattctgaa gaccatcgag aagctcatca aaagaacacg catcatccag atgcaatgtt 2552521 agtccattct ttgttccttt tattgttaca tattgctgct ttttggtctt cacaatattc 2552581 acctcaacaa catactcatt tcgtcaaaaa aagataaaat cctttttact catctctcaa 2552641 ttctttcttt agactcataa aaaacaatct aaatggcaga acaagaataa gagctgctgc 2552701 aatatttaat aaaattgtcg gtataaaccg gtcaagcaca aatccgttaa acgtcataat 2552761 gtctttatga atcaaagact gaatgccgaa tacgtaaaat tcgagcagac agacagccag 2552821 aactgctatc aatatcacta caaatgcgtt tgtatgcaac actttaaacg cttttgaagc 2552881 caaatagcat agccctgcaa aaccaaacat gtaaacgcct aatagacttg tatagttcat 2552941 gtcatataga aagccaaaaa taaatccgta aatcatcgcg tgtttttggt tgataaaagc 2553001 cgacatgaat atcaatacaa gcatcaaaaa acgcggggcg agcacttggt catctgtaac 2553061 gaaaggaaaa tgcaccaaat ctgtaaaaat gctttccgca gaaaaaacaa gcatcataac 2553121 gaaagggaga aggaaacgtt tcacgatcct tcctcctctg tatcgacagt cggcacgtca 2553181 cggttaacaa cgatcacatt atttaaatct gtaaggtcag ccgcaggttt tacataagca 2553241 accttcgtta atccatagga atctgactcg atatcagtca cttcaccgat tgtcagccct 2553301 tctgggaaaa caccgcctgt ccctgatgtt tcaataagat cgcctttttt cacgtcttgt 2553361 ttatccttac gctcaataat tgtcatctta agacgttttt tctctttgtc atatccttcg 2553421 atcaagccgt agcctttgct gccttttttt ccggaaattt ttgtcgcgac tctgttattg 2553481 cggtcagtat cgcttaaaag ctgaacagca gacgtaaaat tgttaagtcc ggagcttttg 2553541 atcttgccga ttaatgcgcc tttttcgttt gtaacggcca tatctttcgc tacgttttgc 2553601 tgagtcccct tgttaatggt gacctgtttc gcccaattat cagggcttct ggcgatgacc 2553661 gttgctaaaa tcggcttgta atctttaatc gatttgacat ggccaagctc gtcacgcaag 2553721 gatttgtttt cttcttcaag ctcttgaagc ttggcttcat attgtgtctg tccgtcaagt 2553781 ttttctctta gacgctcgtt ttctttgtat gtgtttttta aatcattgat gttctcaaat 2553841 attcctgcaa aaaattcggc aggcgtatga aaaatatttt gaaatactcc cgtcgtatcg 2553901 ccgatcactt tctcaggcca ggtggtattg cggccgccct tcagcgaaaa tccaatcata 2553961 gccaccaata tgataataca cagaagtaat agcattaacc gcttattcgg catcgtgtta 2554021 cacctcttct attgaactcc cgattatcta gttttccctt tgaaaagatg gatgtgctcc 2554081 agtgctttcc ctgttccgat cgctacacaa tcaagcggat cttcggcgat aaggaccggc 2554141 atttttgttt cttcgctgat gactttgtcc aaattgcgca aaagcgctcc gccgccggtt 2554201 aacactatac ctctgtccat gatatctgct gcaagctcag gcggtgtttt ttcgagtgtg 2554261 ctcttcactg cttcgacaat tgtagataca gtgtcgcgta gagcgttaga aatctctttt 2554321 cctgtaattt caattgtttt cggcaaacct gtgagcaaat cgcggccgcg gatttccatg 2554381 ttgtcggatt cttcaggagc ttctgcagat ccgatttcca ttttaatcgc ttcagccgta 2554441 cggtcaccga tcatcagatt gtacgttttt ctgatgtagt tgataatcgc gtcatccatc 2554501 tcatcaccgg ctacacggat tgactgagac gttacgatgc ctccgaggga aataatcgca 2554561 acttctgtcg taccgccccc gatatcaaca accatgcttc cagtcggttc ccaaactggc 2554621 agattggctc cgattgctgc ggcaaaaggc tcttcaatcg gatacgcgtc acgcgctccc 2554681 gcctgtcttg tcgcatcgat aacagcgcgt tcttcaacag ctgtaatgcc tgatgggaca 2554741 cataccatta catatggttt tctggcaaac atgcctttat tttttatggc ctgattgatg 2554801 taatatttca tcatcgtcgc cgttgtttca taatcagcga taacgccgtc tttcatcggg 2554861 cgaagagcca ccacgttgcc cggtgtccgt ccaatcatat ttttcgcatc atttccgaca 2554921 gcgacaatcg atttcgtatc cgtctgcaaa gcgacaactg acggctctct cacaacaatt 2554981 ccttttcctt ttacaaaaac aagcgtattc gcagttccaa gatctatacc aaggtctcta 2555041 gcaccaattc caaacatatg tatgtatctt cctttcttaa agcaaaaata ccctaaaggg 2555101 aaaaactcat aaactctatt atagcttaat tcgacgaaaa aaaaagtgtt acaaatatcc 2555161 tttttccttt aaactcacaa attttttatc cccgatcacc aaatggtcaa gcagctcgat 2555221 gccaatcagg tttccgcatt caaacagccg tcttgtcact tcaatatctt ccctgctcgg 2555281 cgtcggatct ccagaaggat gattatgaac acagataaag gaagcggcag atcgtttaaa 2555341 cgcttcttta aacacctctc gcgggtggac aatagatgaa ttcaggcttc cgataaatac 2555401 ggtgcgttta tggatgactt gattttttgt atttaagtat aaacagacaa aatgctcctg 2555461 ggttaaaaag cgcatatcct ccatgacaag attagcgccg tcttccgggg agcgaataac 2555521 gaaatgttct tcgttggcta atttatgaat ccggcttcca agctcaactg ctgccagtat 2555581 ttgaatcgct tttaccatac cgattcccgg gatgcttgac agctcttcaa ccgatgcttc 2555641 cttgagcagg cgcagcccgt caaatgagcg cagcagccgg tttgacaggt ccaaaacaga 2555701 ttcgtgttta gtccctgtcc gcaataatat agccaaaagt tcatgattcg ctaagttctc 2555761 ggctccgact ttcaggagcc gttcccttgg cttttctttc attgggaaat ctttgagttt 2555821 taatggcaga tcgtgtatga ccaagcactc cttttctttc ccttcccgtt tatagaaccg 2555881 tcatgccctt atatcaaaat ggcgaagagc tctcattgtt tttgatatag gaaggcccat 2555941 gactgaataa taatctccgt ctattttctt tacaaaaagc gcgcctcttc cttggatgcc 2556001 gtatgcacct gctttatcca tcggctcttt tgtttcaata tatgtccaaa tctcttcttc 2556061 actgagggac caaaacgcaa cttctgtctt atcataaaaa gtctcgctgt gattttcagc 2556121 ttgaatgctg accgcggtta ttactgagtg acttcggcct gaaagcctcc gcagcataga 2556181 agcagcttct tcttgatcct gcggtttgcc aagacattcg ccgtcaaggc ataccattgt 2556241 atcagcaccg ataacgattg catgcgggtg gagatcagct acagccttag ctttttgttt 2556301 tgccaaccat tggacgtttt cttctggtga aaagtttcga tttaattttt cttctacttc 2556361 actgacaata atggagtagg gcagctggag aagatcgagg agttctttcc tgcgcggaga 2556421 ttgtgatgca agtattagcg gttttgtcat gttcgtcatc ctttcagggt ttgcttaaga 2556481 aaaaaagata ctcgtttatc ctaccaaatc acgaggcttg tcacaatttc agaaaaataa 2556541 ctttttcatg acaaaataaa aaaagcctgt cactaaagga cgaaggctca gggcactatc 2556601 tcttatttta cgacggctaa cagctcctgc tgagccttcc acccggcttc agcacttgga 2556661 tcctctaatt cctttaaagc ctgcaaaatc gcttttttct ctcctgtttc tgacgctttt 2556721 gtttcaccaa gcgacttttc tattttctct acactcgctt ttgtaatgtc ttcgtcgaga 2556781 atcgcctttg ctgcaagctc cgctgtttcc ttaaaagaat ctgtcatatc tgactctatt 2556841 gataaggaaa gctccttgcc tccccaggct tcaaaatcac tgtcgattaa aacctgtcct 2556901 aactgctgtg agacctcctt ttcacttgct aagcctgcaa taacatacgt atacccgtca 2556961 tcctttgaca gtgacacggc ggaatatcct ttttcggtca attgttctgt taacgtttcg 2557021 gcgccctttt catttgaaaa ttttccggct tgcacagcgt atgttttgta tgtaccttca 2557081 gtttgtgccg cttgtttttc tgcgcctgag gtttgtttat cagcagaagt atcccctgct 2557141 tttgccgttt ggctgcctaa agaatcctct aaagaggccg gtgctgacgc ttctttattc 2557201 cccgatatgt ttaacgcgaa taaccctaat ccagtgccaa tgacagccgc gaaggcaatc 2557261 gtcgcggcca ctctttttac cggtttggca gccccggtct ttccttttgc gtaaagcttt 2557321 gtttttttct tttgaaaagg aggaacaact ttagggtcct ctttaaacac cttgtcctcc 2557381 tcggaatccc aattgaattc atcttcatca gggtgttcct gggatgccgc aacctcttgt 2557441 tctgcctgtc ttttttcctc ccaatttgaa aatgtcatgc ttttattcgc ctctgtctca 2557501 ggcgtctctt gttcgtaaac cgtctcttct tttccattaa tcgtcacctt gagggctttt 2557561 tctgcggctt tactgttttt tttattcttt ctttttttca attccgcttc ctcccttcat 2557621 ttgcttgacc gttcttgtcg gcttttcatg ctacacactt tagcacaggc aaagaaaaaa 2557681 agaacaagac ttttgtcgcc ttgtccaaaa aacgttcgtc aaatttttca gcagtcagcc 2557741 caatgccatt ttgatataaa aagaaatgat agagtcaccg tataaatagg ctaaaatgct 2557801 ccctgcggct atagcggggg cgaagggaag cggctgcctt ttagcgagtc taccagtcag 2557861 aacagctgcc gctccatata atgcacctat caaaactgaa aagaaaaagg cagctgccag 2557921 cattttcaca ccaagcacaa agccaatcac cgcaaataat ttaatatctc ctccccctac 2557981 tcccccatgg gtgattgcgg caattacagc cagaaacaaa aatccggctg ccgcacctaa 2558041 caggcctgca taccaggaat caagcggaga aatcaatctc gcggccgcca aaaagggaag 2558101 aaagaaaatc aatattcgat ttggaatcag cataaaatga atatctgtca ctgcaacaat 2558161 aatgagaaga gagataaaca ccacagcggg aaacagttcc agcgatatgc caaagcgtat 2558221 tcctgcggcg gcaaataaac acgctgtcac aagctctgct gcgggataca taaaagaaat 2558281 cctatgcccg cagcttttac atttaccttt ttgaaatagg aatgacagga tgggaattaa 2558341 ttctgcagga gttaatgttc gccggcaaaa cgggcatgat gaacggggcg caataataga 2558401 tagatgtaag gggatacggc acccggccgt atagtaaaaa gaaccaagga taagcccgaa 2558461 gataaaaaga atggatagca tagacaacac acctttactc attgagttct ggtatggatt 2558521 gtagcaaaat ggacatcctg agctccaatt gggaatattc aattttacac atgaaaaaaa 2558581 cggcagaatc tttttttgat tctgccggag ccggatgctt ttatttcaac ctttttcgaa 2558641 tgtcagaaat aaagtaaaga gatccggtaa tcagcacaat ttcatttgag ccctttttac 2558701 tttctatgaa tttgattaca tcgtctggat cttcactcca gcttttattg ctgatttcac 2558761 ttgcatcata gagatctttt gcaagggaag cacgcgggaa atcaaaagaa gcaaaatgaa 2558821 tcgcatgagc aatggtttcc agtcttttaa tcatgttctg atacggtttg tcctttaacg 2558881 cgctaaacac cacagaaatg cgtgaattgg cgaaacgctg cttcatcgtt tccgccagct 2558941 tttcaacacc ttcttcgtta tgcgcaccgt ctaaatatac cggaggatgt tcctgaacaa 2559001 gctctaaccg tcccggccaa gcagccttca caagcccgct ccttaacgct tcgtcactga 2559061 tatgggcgat attctcctta ttgagccact ccgcagccaa aatggacaaa gcagcatttt 2559121 gtctttgatg ggtgccaatc agagatgtcc gaatatcttc atagcatttc tcttccgttt 2559181 tgaatgaaaa ctgttctcct gcaggcagag cctcttcatt gaaaataaca catgcatcat 2559241 gcaatgactg gaacggcgca gcatgccgtt cggcttcatg gcggatgacc tgtaaagctt 2559301 ccggctgggt aactgctgta acgattggaa taccttcttt aataatgccg gccttttctc 2559361 ctgcaatttc ttcaatggtg tttcccaaaa tgttcatatg atcgtgtccg atgcttgtaa 2559421 tcacagttaa gagcggttca accacattag tagaatcgaa tctaccgccc agacctgttt 2559481 caaaaataac aaaatcgacc ttatgaaact ctgcaaaata taaaaatgca caagctgtca 2559541 taatttcaaa ttctgtcggc tgtccgtatt ccgtttgatc aagggcttca acgtgcggtt 2559601 tcatttgatt gacgagtgct gtccattcct catctgaaat cggtatcccg tttacgctga 2559661 tccgttcatt aaacgtaata atataaggcg atgtaaatgt tccaaccgta tatccggctt 2559721 cctgcagcat agaacggata aaagcgacag ttgatccttt accgtttgtt cctgcgacgt 2559781 ggaacgctcg gatttttttt tcaggatgtc ctaaccgcgc catcagctgt ttcattcgac 2559841 caagtccggg cttcaccccg aatttcagcc tcccgtgaat ccagctgcgc gcatcttgat 2559901 atgcagtaaa caatgataat cccctctttt ataagacaag gcggtttctc tagaaaccgc 2559961 cccggctttt cattaaccct tcagctcagc cattcgtttt tgaacagcgt cacgcttcgc 2560021 cacataatct ttttcttttt cacgttcttc atcaattacg tgtgcaggcg cttttttcat 2560081 aaatccttca tttccaagtt tcttttggac acgctcaact tcttttgtca gtttatcaaa 2560141 ttctttttgc agacgggcaa tttcttcatc aatattgatt aagccttcaa gcggaagaat 2560201 aacctctgct cctgagacaa cggccgtcat cgccttatca acagcctcaa tatcggtgcc 2560261 gattttaagc acgctcggat tcgtaaagcg ttcaacatat gaacggttcg cttcgaggcg 2560321 ggacgctatt tcgtctgtgc ttgttttaat gtacagttca acctgcttgc tcattggcgt 2560381 attgacttca ctgcggatat tgcgcacaga acggatcagc tcaacaagaa gcttcatgtc 2560441 agctgccgct tcagtatcgg tatgctccgg cactactgca ggccattgac ttactgtaat 2560501 cgattcccct tggtgaggaa ggtgctgcca aatttcctcc gttaagaatg gcataaacgg 2560561 atggagcaga cgcatcgttt gatcaagtac gtaagcaagg atggaacggg tagttttctt 2560621 agccgcttcg tcttctccat aaagcggaag cttcgccatt tcaatatacc aatcacagaa 2560681 atcatcccaa ataaagttat ataaatggcg tcctacttca ccaaattcat atcggtcagc 2560741 aagctgggtc acgtgctcga tcgtttcatt taatcgcgtt aaaatccact tgtcagcgac 2560801 tgacttttca cctgacagat caagctcatc gtacgtcatg ccatccatat tcattaatgc 2560861 aaaacgggag gcgttccaaa ttttattggc aaaattccag gtcgattcca ctttttcata 2560921 gctgaagcgc agatcctggc caggagagct tccagtcgca aggaaataac gcagagaatc 2560981 ggctccgtac ttgtcaatca catccatcgg gtcgacaccg ttgccaagag atttactcat 2561041 tttccggcct tgctcgtcac ggattaagcc gtggattaaa acatctttga acgggcgctc 2561101 gcctgtaaat tcaatgcctt ggaaaatcat gcgtgatacc cagaagaaaa tgatatcgta 2561161 ccctgtcacg agaacatctg tcggatagta gcgtttaaag tcttcagccg ttacatcagg 2561221 ccagcccatt gtggagaaag gccatagcgc agaactgaac catgtatcca gtacgtctgt 2561281 atcctgttcc caattttcgc tgtcttccgg cgcttcaagt ccgacatata gctcgcctgt 2561341 ttctttatga taccaggcag gaatacgatg gccccaccac aattgacggg agatacacca 2561401 gtcgcggata ttttccatcc agtgtaaata cgttttttcg aaacggtcag gcacaaagtt 2561461 gaccttttct tctttttttt gcagctcaat cgctgcatca gcaagcggct gcatgcgcac 2561521 aaaccattgt gtagaaagat aaggctccac aacagccccg cttcgttcac tatggccgac 2561581 agagtgcata tgatcctcga tcttgaagag aactcccgcc tcctgtaaat ctttcacgag 2561641 ctttttgcgg cattcaaaac gatccatacc ttgatattgg agcgcatttt cattcatcgt 2561701 gccatcttca ttcatgacaa ggatgcgttc taaattgtgg cggttgccaa gctcgaagtc 2561761 gttcggatca tgagcaggcg taattttcac ggcacctgaa ccaaattcca tatcaacata 2561821 gtcatcaccg acaatcggaa tttcacgatt tacaatcggc aggatcaccg tttttccgat 2561881 aaggtgttta tagcgctcgt cttcagggtg aacggcaaca gctgtatcac cgagcattgt 2561941 ttcaggacgt gtcgtcgcaa tttcaattga gcctgaaccg tcagcaagcg gatagctcat 2562001 atgatagaat gcgccttgaa catccttgta aatcacctca atgtcggata gggctgtttt 2562061 tgtcgctggg tcccagttaa taatatattc gcctctgtag atcaggcctt tttcataaag 2562121 cttaacgaat acttccctta ccgctttgct caagccttca tccagcgtaa aacgttcacg 2562181 ggaataatct aggccaagac ctaatttcgc ccactggctg cgaataaagt cagcatattc 2562241 ttccttccac ttccacgttt cttcgaggaa tttttcacgg cctaaatcgt agcgggattt 2562301 gccttcttca cgaagtttcg cctccacttt agcctgtgtc gcgatgccgg cgtggtccat 2562361 gccaggaagc cacagcacat catagccctg catgcgtttc attcttgtta caatgtcttg 2562421 cagcgttgtg tcccatgcgt ggccaaggtg aagtctccct gttacgtttg gcggcgggat 2562481 gacaacagag tatggctctt ttgtctggtc actgcccgct tcaaaaaatt tgccttttag 2562541 ccaaaaatca tatcggtctt tttcaaccgc tgccggatca tatttcgtcg gcattgtttg 2562601 ttcattcgtt tccatcataa ccctccagca tgtttaaaaa tggctgagaa cgaaaaaaga 2562661 gctcttcatc cctgtaaaag gacgaaaagc tctttcgcgg taccaccttt tttcatgaac 2562721 tcaatcagtt catgcactta taacggataa cgggtgtttc ccgaatttct ctactcttct 2562781 ttcaagaaat tatgctcccg ggcgaccttc caatcagaca acataagaag cctttcagca 2562841 aacggcttct ctctctgcat gcgccttttt tgtactcttc ccgttctaag caggtgtatt 2562901 tatcagctca ttgtatacat tatttatgtt ctttattata gtaaaagtgt ttttgattcg 2562961 tcaatcatct tttccaaaaa caccgctttc tatacagatg ggcaggcacc tattgcccaa 2563021 gtttacatat gatgcttgta aatgcgtaga ggaggatgca ccgtgaagaa acgtttcagc 2563081 tcttattcgc tgccgccatg ggtaaggcaa attcggcttg tatccgcaca agtgattatt 2563141 cccattacga tttttcaagg aatcagaacc attttctttc cgacaacctt tgatgttttg 2563201 ctgctcgcaa tcctaatctt tttagcttgc gcccttcatt tagaatggat ataaacaaac 2563261 aagtccgcgc cattaagacg tggactcgtt ttcagcctga aattttttct cttgttcaat 2563321 ctgatgaatt ttcatcacaa acggctctat gtttttcatt tgccaataag cctttaataa 2563381 ttgtgtacat tcctcttttt catgctgtct tttcccagtt tgataaccgt tcagcacctt 2563441 gtacatggct gccggatatg ccatatagct gagaaaaagg ctgacttccg cttcacgcaa 2563501 agggaatgat ttcgtatatc cataaaacca ttcgacgcat tccggacaag ctttcggaaa 2563561 gcctctgaac atttttgtat aaaagccgag caggtcgttt tgcggcggac cgacagatgc 2563621 tctttcgaag tttgtaaaat atccggtccc ggcatcatta tacagaaaat ggtgtataga 2563681 caggctgccg tggttcatta caacccttga aacgtccttt tcctttgcgg actcatacca 2563741 gtcctccagc cgttccagcg caaagttcac cgcggaaatg gtttcagaaa aataggttat 2563801 ggcctggagt tcaaagggag aaaggtacca ttccttctcc gctctatcca caaactgctc 2563861 atagaaaatt ttatcttgtt cccacttttt tttcgtttgc ccgtaataac gttcaatctc 2563921 atcacgtcta acctttagtt cctgcgcggt tctctcgtga agacgggctg tttctctaaa 2563981 taaataagca tgtttttgat cccgttcttc ctcttggtca aattggagcc aaggcattaa 2564041 atagtagata tctccgtatt gtatgcctgc tgagaaaaac tcaccgctat ttgttctgta 2564101 aacgggaacg aatgaacgaa agcctttttc ctcaatcgcc accatatgat ctgtaaaatg 2564161 cttgccgcga ccttctttca attttttcag ggcaaatatg ccgtagtctg tatacacttt 2564221 ccaaacaaga ggactgacag gctcaataaa ttgagcagtc agtccgtatt cctgaagaac 2564281 cgattgggta tcttccattt cattcaccac attttccgat cacttacggt ttacgcatgg 2564341 ctatttttat attgaggaat atagagaatc tgtcctgctt ttaattcatc atccaaggct 2564401 aaagaattca tcctgatcag ctgctgggat gtaatttcat accgttcgca taaacgctcg 2564461 atcgtatctt cctgctgcac aatacaaatt ttcattctcg aaaactcatc cgcttctttt 2564521 gtaaagagtt ttgttaaata aagagaatta tcactttcct ttgtttgagg ttccttcgtt 2564581 tcagcagcag gagcaaccct aggaacagca tccgtttcct tcctttcagt ctcagaagat 2564641 tcaggcagct ggaaggattg aaaaggtgtt tcttccttag gctcttcagc tgatggtgtt 2564701 tttctcactt caatttcgaa gctctcttcc tcttgttctt cctcctccag cagcttaggc 2564761 gctgaataaa aagaatcctc ctcttcttgt tcaggcagga aggtacggta tgccggttca 2564821 ggcaattctt cttgagatgc ctcctccgag cttgtttttt gattgaaatg gaaatgtaaa 2564881 tcggcattgt cattctccat atatacagct gaagctgttt ctctgctatc ttctatggag 2564941 agagcggcct ctgatacact ctccaaagct tcatccggtt ccgcctcttc ttggcaaagc 2565001 gcaggatcag cctgatccga ttgagctgct tcttcatttt gagcctcttg gcgcagcgca 2565061 tattcatgat taggagacac tgttgtttcc tctttttcct ttgcaatcac agtctctgaa 2565121 tgaagctcag cttccaaagc aggcgattct tctgctccaa cgtgttcacg aagctcagtc 2565181 tccgctggag agtctgcttc ttcacgaaca tccgctattg cagctgccgg ctctgccgtt 2565241 tctttttttg ctttaacgat ctcttgaatc tctatttctg aaggatcagg ttctggctca 2565301 gattcttctg tttccgattc agcacgaacc tccgtttccg gcacagcaag ctcttctgac 2565361 tcttcttcct ctttcacatc ttctctggcc tctggttctg aagcaaccga ttcaggcggc 2565421 tcagattctg ctttttctgt ctccagttct tcacggagcc ccgctttcga gataaaaagt 2565481 tctggcggtt cggctggcgg ttcatgctga agaactgctt cctctgccga tgatgcaccc 2565541 ggttcttcta ctacactatg tgccggcggc tctgaaagct cttcctccct gaatgccgca 2565601 ggagcttcat ataaaggtat ctccggctct ttgtcttgcg tatcgtccaa aagcccttcg 2565661 atcgctaaat cagcttgaat tgttaaaatg cgcgaatccg tcaattgata gtcaaatgcg 2565721 tcaataaaga cgaagacatc ctgtaaatgg ctcactttat ttttcggaat ggtaatatcc 2565781 acaggaaaac agtgagtcag ttccgcactt ccatcctctc tctttctgac ttgttcaaca 2565841 aaccgcttat ctgtataaat ctcttcggta tgtttgtttt gatctatgtt gtactcacct 2565901 gtaagttcaa gcgatcctat gattgataca taatcattta cttcctgaac cctaatatca 2565961 ggatctaatg aaatagaaag cagttcagaa acttcctgtc ctttttggaa acagatcgat 2566021 tcttctacag aaaattgcaa tcgatgattt tgcggcaagt tcatatcctc ctttcatcta 2566081 atccttaaaa ttagatgtca ctaaaggtgt atgtatgaac tggagaaaat atgagtggga 2566141 gagcacgaaa aaaccggcac aaggagtcct tgataccggt tttcactctt atctgcggct 2566201 gatctcagca aatactttct cagctgcctg gattgtgttt tcaatatctt catcagtatg 2566261 ggccgttgag aggaaaagac cttcgaattg tgatggcgga aggaataccc cttcatttgc 2566321 catcccttta taatagcttg cgaacagctt caaatcagat gatttcgctg tttcataatt 2566381 gatgactggt tcgtttgtaa agaagaaacc gatcatcgaa cctgcacggt taaaggtatg 2566441 cggaatgcca tgagccccgg cggtttttga aattccttct tccagtctgt cgcctttttt 2566501 gatgaaattc ttgtaggatt caggtgtcag ctgtttcaat gtctctaagc cagccgtcat 2566561 cgcaagcggg ttgcctgaca atgtaccagc ttgatagatc ggaccgcttg gagcgatctg 2566621 ctccatgatt tctgcctttc cgccataagc gccgacagga agtccgcccc cgattacttt 2566681 tcctaaacaa gtcagatcag gcgttacgcc gaagtagcct tgagcgcagt tataatcgac 2566741 ccggaagcca gtcatcactt catcaaaaat cagcagggag ccgtactgct cagtgatatc 2566801 acgcagaccc tgaaggaaac cttcttgcgg cggaacaaca cccatatttc cggcaactgg 2566861 ctctacaatg actcccgcaa tgtcttcacc gaattgctgg aaagcaagct ttacactttc 2566921 taaatcattg tacggaacgg tgatggtgtt tttcgcaatg ccttcaggca cccccgggct 2566981 gtcaggcaga ccgagagtgg caacacctga accagcttta atcaagagag aatcgccgtg 2567041 tccgtggtag cagccctcaa attttaaaat cttgttgcgg cccgtatagc cccttgccaa 2567101 acggagggca ctcattgtag cctctgttcc ggagcttacc attcgtacaa tttctacaga 2567161 tggcacacga tcaatgacga gcttagccag ttcattttct acttcagtcg gagcaccaaa 2567221 gcttgtcccg tattcagcca cttttttgag gctttctacg acgcggtcat ttgtatgccc 2567281 taaaattaaa ggcccccatg acaagacgta gtcaatatat tcattcccgt caatatcaaa 2567341 gattttcgag ccttttccgc gctccataaa aatcgggtcc atgtctaccg atttaaatgc 2567401 gcgaacggga ctgttcacac cgcccggcat gagtttttgc gcttctttaa aagccgtttt 2567461 tgatttttca tagcttctca tctgcctcaa ctcctgtcaa ctgaataaaa ttactccgca 2567521 agccatttcg ctgcgtcttt cgcatgatac gtaataatca ggtcggcacc cgcgcgcttc 2567581 atgcttgtca aaatttccaa cacaatttct ttttctttga tccagccgtt ctgcgctgca 2567641 gccttcacca ttgaatactc tccgcttaca ttataagcga cgagcggcaa agtaaactca 2567701 ttttttacgt cacgcatgat atccatataa gaaagcgaag gtttgacaat caaaaagtcc 2567761 gcgccttcct caacatctga ttgtgcttcg cggagtgcct ccatacggtt ggcagggtcc 2567821 atctgatatg ttttgcggtc tccgaattgc ggtgtgctgt ttgctgcatc acggaacgga 2567881 ccgtaaaact cacttgaata tttaacagcg taagacatga tgggaatatt gacgaatcct 2567941 tctttatcaa gtgcttctct gatcactgta acaaatccgt ccatcatgtt tgatggcgca 2568001 atgatatccg cacctgcttt cgcttggctg acagctgtct gcgccaaaag ctccagcgat 2568061 tcatcattga gaatgactcc gtctttgaca agtccgcaat ggccgtggtc tgtatattcg 2568121 cacaggcacg tgtcagcgac aacaaccatt tcagggaagt gttctttaat ttctgtgatg 2568181 gctttttgga caattccgtg atcatggtac gcttgtgttc cgcaatcatc tttttcttcc 2568241 gggatgccga acacgataac agattgaatg cccagtttga ccagctccgc tacttcatcc 2568301 ttcaataaat ctaatgatac atggtgaaca tcaggcattg acggaacagc ttttttgcct 2568361 tccagccctt caacgacaaa aatcggatat ataaaatctg atggatgcaa acgtgtttcc 2568421 tttaccattt ctctcattgc ttttgatgtc cgcaggcggc ggtgtctatt aaatgattga 2568481 ctcatattct ctcttcctct cttgacatgc tgcacattaa ctcaagcatg ccatctattg 2568541 taaatgtatc aggcgtatgc gatgtgatgc cgtacgtcag aagggcatca tttgttaaag 2568601 gcccaatgct gatacaggcc gtcccattcg ccttccactt ttttaattct tctcccaaga 2568661 catgcataaa cgtatgtacg gttgatgaac tcgtaaatgt tacatagtca aaggaatatt 2568721 gacccgcagc gtctttcaat gcctcaatgc cttcttcatc cggaatcgtt tcgtagagaa 2568781 cccattcctt tacttcaaaa ccgagcggga caagctcttg ttttatcaca tcacgtgaca 2568841 aattcccttt catcacggta atggtctccc ccggttcagc atgctgctta agagcgtcag 2568901 ccaattgttc agcaatatac tcctgtggca tcacatcaac cgatacgtta tgcattttta 2568961 aacggcgcgc ggttttttca ccgacggctg caattttttt atgcgcaggg agaataagct 2569021 gattttcctt cagataagaa aaaaagaagt ctgccccgtt cacacttgta aaaacaagcc 2569081 agcctggcgc ggcaagatcc tctcttacct gttccgcaac atcattcggc aaagcgcggc 2569141 gaaacgtaat caaagaggtt aaaaccgctt taccgccaag cgcctccact ttttgctgaa 2569201 atgatgctgc ctgtgcctta ttccgggtga caagcactgt ttttcctttc aacggaaaat 2569261 cattttccat cctcgtcaag ctcccgtttt acacgatcaa ttaaatcttt tgctcctttg 2569321 tcagccataa gagcggcaca gcgctttcct acttcctccg gatcgtttcc ggtgacggtt 2569381 tctttaaaaa tgattttgcc gtcaggtgaa gcgacaagac ctgtcatttc aatttcatcc 2569441 tgtccattta acacggagta gcccgcgatc ggaacctggc agccgccctc catcgcgttt 2569501 aaaaaagcac gttccgctaa gacagtccgt tttgtatatt catctgtaaa ctgagaaaac 2569561 aacgccaaca gctcttcatc cgattctcgg cactcaatcg ccagggctcc ctgccccaca 2569621 gcaggcaaac agcgctcagg ctcaaggaat tcggttacga catcttgctt ccaacccatt 2569681 ctggaaaggc cggcagccgc taaaataatt gcgtcataat cctctgtttc cagcttttga 2569741 agtcttgtat ctatattacc tctaatccat ttaattgtaa ggtcagggcg ctcaatcaaa 2569801 agctgcgcgc ttcttcttaa actgcttgtg ccaatgacag cacctttctt catttctgaa 2569861 agctttacgc gattctttga aataagggca tcacgcgggt cctcccgttc aggaatacag 2569921 ccgatcacaa ggccttcagg caaaacagca ggcatgtcct tcatgctgtg cactgccata 2569981 tcaatctctt cgtttaaaag cgcctgttca atttctttga caaaaagccc ttttccaccc 2570041 acttttgaga gtgtaacatc gacaatccgg tcgccctttg tcacgatctc tttaatttca 2570101 aaagcaaacg aaggattgat ttccttcagt ttttgaataa cccattttgt ttgagtcata 2570161 gcgagtttgc tccgtctgga acctacttta atcgttctca tcatttcttt cctcccgaat 2570221 ctgcttggga catcgtttaa ctgaaccaat ggaattgcga caggcttcca agcaggaaat 2570281 aattgatcat cagcaccaga aaacaagccg tattccacag tgcagcgacc tttccttgca 2570341 gctccttaat cagcctgata taaagataat agctgtacag cagcaggacg acaaacgaac 2570401 caagcacttt ggcgtcaaac caatacagcg tttctagtga gacatacgcc caaatgacgc 2570461 cgagaatcaa actcagcagc agcatcggaa ccccaatgac atttaaaaca tacgccatat 2570521 aatcaagctt agataaatct tctattctca acagccattt tccccacttt ttctttttca 2570581 gcagatgata ttgaaacata tatagcacag aaaaaacgaa agaaagggaa aaagcgccgt 2570641 atgaaagaat cgccattgta atatgaatca ccaaaagctc ggatacaagc tgcccggaaa 2570701 aagcagctga ctgctgctct gtcggtgaaa atgtgtgaat ggcgatcata gaaaatccta 2570761 taacatttgt aaaaaacacg ataaagtcaa cacgtaaaag ctttgtcagt acaagtgaca 2570821 gcgtgacaag cacccaggca taaaaataaa gtgcctctgt cacatttaat accggaaacc 2570881 gccccgtcac ccacataaaa taggccaaat acacggtttg cagagtccag acaatagaaa 2570941 gcaaccagaa ggccattttt ccagccttcc ggttgtgttg aagaaaatct ataaaataaa 2571001 agagtacact taacgcgtaa atgacgattg tcccctcatt aagtcttgcc attgcagtat 2571061 caatcattca gctttcactc acttacaagt gggctaaagc ccgcttttga ttcagccttc 2571121 ttaaaagagt ggaccttctg gctgctttca acggttttca tcatttgacg gcccgcagct 2571181 tcttcaatat caaaaatctg cataaacaac gcgagctttt cttcagaatc agcatctgcc 2571241 gcaagctctt tcacctttaa aatcggatca cgaagcattt ggttaataat acttttggtg 2571301 tgtttgttca acagtttttt ctctcttgtg cttaagtgag gcagcttacg ctcaatgctg 2571361 tccatcgttt ctgactggat ggcaagcgcc ttttcgcgca atgcagaaat aacaggcaca 2571421 acaccaagtg tattcatcca ttgtttaaat tccacaatgg tttcttcaat taacagttca 2571481 actttttcag ctgtttctct ccgctctttc atgttcgctt ctacaatgcc ttccagatcg 2571541 tcgatatcat aaagaaaaac accttcaaga tcattcagcg ccggatcaag atctctaggc 2571601 acggcaatgt cgaccataaa cagcggacgt cccttgcgaa gcttattcgc gttttccatc 2571661 atctctttgg acacgacaaa ttcacttgca ccggttgaac tgattaaaat atcagcctcc 2571721 gcaagcgcgc tttcaagctg attcaagctt ctcgcttcac ctgaaaaacg gtctgcaagc 2571781 tccttcgctt tcaagtatgt tcggttaatg acagtgacct tgccgattcc ctgtccgtgc 2571841 aggttttccg cagcaagctc gcccattttt cccgcaccga gaatcaatat gtgcttgctt 2571901 gaaagatttc cgaagatttt tttggcaagt tcaactgcag catagcttac tgacaccgca 2571961 tttgagccaa tgtctgtttc ggcgtgagtc cgtttgccca ctgtaactgc ctgcttaaac 2572021 agctcattaa aaatagtccc gatcgttttt tcttgctgag ctgttttaaa gctgtcgcgt 2572081 acctgtccga gaatctgcgt ttcgccaatc accatagaat caagtccgca ggctacacgg 2572141 aataaatgct caacagcggc atcgctctca taaaacgtta agaacggtga cagctcttct 2572201 ttgcttaatt gaaaccaatc agctaaaaac ttttttatat aataacggcc ggtatgaagc 2572261 tggtcgacta ccgcataaat ttcagtgcgg ttgcaggttg agacaatgat gttttcaaga 2572321 atgcttttct cttctttcag ctgcaccatt gcttctgcca gctcattcgg ctgaaaactt 2572381 actttttcac gtatctcaat aggggcggat ttataatcta ctcccacaac aagtatatgc 2572441 atcgctctaa ttacaccccc aacacccaat cttaatttat aatcattcta acatagaact 2572501 cattatttat aataattata acatagtttc tttcacaaaa tgtgaacaga ttttaaaatt 2572561 cttatgctat attagaaaaa gcttcaggga aaagaagcat tcctattgac aataccaaaa 2572621 acagcagaaa tttactacac atcagctcta aaaaacaaga aggtgatatg catgaaacaa 2572681 aaatcaattt tattcccttg tctgctgctt gccgcttctg tatatgcatg gctagaaagc 2572741 ggccaagccg aactgttttc agggcaggat caatggcctg ttctcctcat gctgttaggc 2572801 gcagcctttg tatatcaagg aaaaaaagaa gccgtcacac cccatttttt tatcggtttg 2572861 cttctcttcg ggatcggttt acactttttt gccaagccga aatgggtatg gtggccggat 2572921 gattttgaaa tgctcctctt tatgatcggc ttctcacttc tcgtttcaac cgttcaaaaa 2572981 aaagaatatg tatatgaagc tgtgtcgatg atttgttttt ccctgttttt gtactttttc 2573041 aaacaaatta tggcatggct tgagtctgcg catattccaa cagcgcttct gaaggagtat 2573101 tggccgtttg tctttattgg aatcagttta ttgttattat tgataaaacg aaaaaaatct 2573161 atacgataaa taaaaccggt agaggatcct ctaccggttt atcatttttt tgatcgctcc 2573221 ccaagcttcg tcttttccct ttttcgtttc tgaagaaaag aggatcagct cgtcttccgg 2573281 atcaatattt aatgtttgtc ggacaacctt cgcgtgtttg tcccatttac ctttcgggat 2573341 cttatccgcc tttgtagcga taacaataac aggaatgccg taatacttta aaaattcata 2573401 catctgtaca tcatcattag atggcgcatg ccgcaaatca acgatctgca ccacagcttt 2573461 taattcctcg cgtgtcgtga tataggtttc aatcattctg ccccatgctt cacgctcaga 2573521 ctttgacact ttggcaaaac cgtagcccgg cacatccaca aaatgcagct catcattgat 2573581 aatgtagaaa ttaagcgttt gtgtttttcc cggctttgat gacgttctcg caagattttt 2573641 gcgattgatt aatgaattga taaaagacga ttttcctacg ttcgatcttc cggccaatgc 2573701 gatttccgga agcccccctt cagggtactg ttccggtttt actgcactga tcacgatttc 2573761 tgactttgtg actttcattt cttctctcct actaaggcat gttccaaaac ctcgtctaag 2573821 tgggacgcca atataaatgt cagcccctcc ctgacgcttt ccggaatatc ctctatatct 2573881 ttttcattat ctttaggcgc aataatggtc gttaatcccg ctctatgtgc gccaagcgct 2573941 ttttccttta agccgccgat cggcagcacg cgcccgcgaa gcgtgatttc cccagtcatg 2574001 ccgacttcac gcgaaaccgc ccgtcccgtt aaagcagaaa caagcgctgt tgccatcgta 2574061 ataccggctg acggaccatc ttttggcacc gcaccctctg gtacatgtat atgaatatca 2574121 tacttctcat gaaagtcagg ttcaatgcca agttcttctg ttttggatcg cacatagctg 2574181 aatgcagcct gagcagactc tctcataaca tctccgagct ttcctgtcag gattaatttc 2574241 ccttttcccg gtgaaagcga tacttcaatc gaaagcgtat ctccgccaac ggttgtatac 2574301 gcaagccctg tcactacacc aacttgatcc tctgtttcag cttgtccata tctgaaaatg 2574361 cgttttccga taaaatcttg aaggttcttc tcagtaaccg taattcgttt tcgctcttca 2574421 gcaacaatgg cttttgcagc tttacggcaa attgcggcaa gctggcgttc aaggcttctt 2574481 acacccgctt ctctcgtata gtaacgaata atatcaagaa tcgcctgatc acgcagctga 2574541 agattgcttt tcttcagccc gtgttctttg atttgctttg gaagcaagtg atcctttaca 2574601 atttcaagtt tttctatttc tgtgtagcct gcgatattaa taatttccat tctgtctctg 2574661 agcgggcccg ggattgtggc caaattgttc gccgttgcga taaacagcac tttggataaa 2574721 tcaaaggttt cttcaatata gtgatcactg aagctgctgt tttgctctgg atcaagcact 2574781 tcaagcatag cggatgatgg gtctcctcta aaatcagatg acattttgtc aatttcgtct 2574841 aataagaaga ccggattcag cttgcccgct tttttcatcc cttgaataat acgtccaggc 2574901 attgctccga cataggtccg tctgtgtccg cgtatctctg attcatcccg aactcctccg 2574961 agtgagattc tgacgaattt gcgtcccaag ctttttgcaa ttgatttggc taaagacgtt 2575021 tttccgacac ctggaggtcc tgccaaacag agaatcgggc ctttcaggga ttttgtcagc 2575081 ttctggacag ccaaatattc taaaatacgt tcttttactt tttcaagccc gtggtgctct 2575141 tcgtccaaga gacgtcctgc ttctttcaaa tcaagcttat catctgtttc atccgtccac 2575201 ggaagagcaa ccagccagtc gatatagttg cggatcacag agctttccgc agaacttgac 2575261 ggaatttttt catatctgtt caattcttta agcgctgttt ctttcacatg atcaggcatg 2575321 cctgcttctt cgattttttc cgtcagcgtc tgaacttcgc cagttttgcc ttctttatcg 2575381 ccaagctctt tttggatcgc cttcatttgt tcacgcaagt agtattcctt ctgcgtacgc 2575441 tccatcgaac gtttgacgcg ctggccgatt tttttctcaa tctccagcac ttctttttca 2575501 ttattaataa aatcaatgac cttgttcagc ctgtctttga catcagccgt ttctaaaata 2575561 tcctgcttat cctttagttt aaggggcaga tgagaagcaa cgatgtctgc cattctcccc 2575621 ggctcttcga tatcagtaac cgcagcgtac gtttcggccg agattttttt agaaattttt 2575681 atgtactgat caaagtggtc tagcaaagtc cgcatcaatg cttcgtcttc tgtatctttt 2575741 gaatcatctt catgaataag ttgaatgtca accgacgtgt aatcctcgtg ttcattgtat 2575801 ttgacgatat gggcgcgctt gaggccctcc accaacacac gaatcgtacc gttcggaagc 2575861 ttcagcattt gcttaatttt tgtataggtg ccgacagtga aaatctcgtc ttcaccaggt 2575921 tcgtctatcg aaatatcctg ctgagtggct aaaaatatca tatgatcatg catcattgcc 2575981 tgttcaagag cctgaaccga cttgtcacgt cctacatcta aatgcaaaac catcgtcggg 2576041 tacactaata aacctcttaa agggaggagc gggatgctgc gttttaattc ttctgccatg 2576101 tgactgacac ctccgtgact ttagtatgaa ccattataat acaacttttt catccttgta 2576161 caataaacgg catggttcca ttttctataa aacagtctcc tcgtagtata ccctttcttt 2576221 ctgatatgaa aaaggaaaag atgtccttca tgaaaaaaac cctattatca aaatagggtt 2576281 taaacggatt ctttattgat ttcgatatga aacggttttt gttccgttgg cggattcacc 2576341 aaaatttcat caagcacttc ttggaacgtc ttcactgcaa taatctcgat cccgtcaatc 2576401 tgctttaaga tggcctgctg attttcatat gggataatca cctttttcgc accggactgc 2576461 ttggccgctt ttattttcgg aatgacgcct ccgatgggtt tcacaagacc gttcaggctg 2576521 atttcgcccg tcatcgcaac ggtattgtca ataggaattt tgtgtatcgc cgagaaaatc 2576581 cccgccgcca tcgcaatgcc tgctgacggc ccatcaatcg gaatccctcc tgggaaattg 2576641 atgtgaatat cataatcaga aggcttcatt cccattgtcc ggagcacggt taatacattt 2576701 tcaaccgaac ccttcgccat gctttttcgc ctgatcgatt ttgattggct gccgatgctt 2576761 tcttcttcag ctattcctgt gatgttaatt gatcctttat cttgagccgc ggttacactt 2576821 acttcgattt ccagaagcga tccgctgtta ggcccataga ctgcaagccc atttacaatg 2576881 ccaacctgtg gttcaacacc gattttttgc tcgtgctttg gagtaagctg actggagtga 2576941 atgacccatt caatatcctc aatcgtaatg tcctttcgat tctccgttac agccatcccc 2577001 gctgcgattt gaatcatatt gacggcttcc cgcccgttcc gcgtgtagct ggtcaaaaga 2577061 tccagtcctt cttcggagat atttttttca attttatccg ctgctgtttt ggcaaccgtt 2577121 ttcagctcgt ccttttcaag ctcgcggaaa aaaacctcca aacagcggga ccggatagct 2577181 ggcggaattt cgtttggcat tctcgtggtc gcgccaatca agcgaaaatc agccggcagc 2577241 ccattttgaa aaatatcatg aatatgattc ggaatttgtg tattttcctc actgtaatac 2577301 gcactgtcta aaaagacttt tctgtcctca agcaccttca gcattttatt catttgaata 2577361 ggatgcagct cccctatttc atcaataaac agcacaccgc catgggcatg ggtgacagct 2577421 ccctgcttcg gctgcggaat cccagcctgt cccatcgctc cggccccttg gtatatcggg 2577481 tcatggacag agccgatgag cggatcggca attcctcttt catcaaaacg ggctgttgtc 2577541 gcatcgagtt ccacaaagac agcctgctct ttaaacggtg attgtttatg tttttttgct 2577601 tcttccaaca caagccgcgc agcagccgtt ttcccaactc ccggtggccc atagacaatc 2577661 acatgctgag gatttggccc gcataaagcc gcctttaatg ctttaatgcc gtcttcctgt 2577721 ccgacgatat ctttaaagct tttggggcgg accttctcag ataatggctc ggacaagctg 2577781 atagcgcgca ttttccgaag ctgctccatt tccttctttg attctttatc tatcgtgacc 2577841 ttttgtgtcc tttgattttt aagcaaattc caaaaataca aaccgatgat gatcccaaaa 2577901 aacagctgaa taaataacgc gatccctgtc caactcatgg tggtccctcc tgaaaaacaa 2577961 tttatgtatc caattcattc ctctgattgc tagtatctcc catagaagac gggaataaac 2578021 gtttttccgg aagagttgca tgcaaaaaaa cctcctgagt gttaccactc aggaggtttg 2578081 tgcttatctt tatgcagatg ttttatcttg gcttacctca gtgccgtctt ttaataagag 2578141 gcgaggaggc tctccgtgtg tcacagttgc cccggtgatt acacattttt caatgtcatc 2578201 acgagaaggc agctcaaaca tcacatcaag catgatgcct tcaatgatag aacggagtcc 2578261 gcgtgctcca gtcttgcgtt caattgcttt tttagcaatt tcagaaagcg cttcttcttc 2578321 aaactcaagc tcaacgttgt caagctcaag cattttcttg aattgcttaa caagagcgtt 2578381 tttcggtttt gttaagatcg caaccaatgc ttcttcgtca agcttttcaa ggcttgcaat 2578441 aaccggaaga cgtccgataa attcaggaat taacccgaaa cggagcaaat cttctggaag 2578501 cacttttgaa agaagatctt ctttctcaag atcagcagct ttattgtcgg caccgaatcc 2578561 aatcactttt tggcctaaac ggcgtttgat gatttgttcg ataccatcga aagctccgcc 2578621 gcaaatgaac aaaatatttg ttgtgtcaat ttgaatgaat tcttgatgag gatgcttacg 2578681 tccaccttga ggcggtacgc ttgccactgt accctcaaga attttaagca atgcctgctg 2578741 tacaccctca cctgacacat cacgtgtgat agacgggttt tcagattttc tagccacttt 2578801 atcgatttca tcaatataga taatgccttt ttcggctttt tccacatcat aatcagcagc 2578861 ttggatgagc ttcaagagaa tattctctac atcttcaccc acgtatccag cttcagtcaa 2578921 agatgtagcg tccgcaatcg caaacggcac atttaaaatg cgagccaatg tttgcgccag 2578981 aagggtttta ccgcttcccg tagggccgat taatgaaata ttactttttg aaagctcaac 2579041 atcatcaact ttgctgttgg agttaatgcg cttatagtgg ttatacacag caacagcaag 2579101 tgatttcttc gcttgatctt ggccgatgac atattcattc aaaatttcgc gaatttcctg 2579161 aggctttggt acgtctttaa attctacttc ttcttctgtt ccgagttctt cctctacaat 2579221 ttcagtgcag agttcgatac attcgtcaca tatatataca ccaggtccag ctacaagctt 2579281 acgaacctga tcttgtgttt ttccacagaa cgagcatttt aattgtcctt tttcctcgtt 2579341 aaatttaaac attctttcac cccttaatct tgtctcactt tttcttttac cggcagagca 2579401 aaagaaaatg attcttgaaa cgaacgagta tgtattgcat tttaccatac tttccaaaaa 2579461 gacggtaaca atgtgtttct gacttgcaca ttctatatgt atgacaaaaa acagccctgc 2579521 attaactata ttgccccaag aaaaagagat aactcataat tgtacaaaac aaggcacgaa 2579581 tgattcgcgc cctgttttat tagtactatt attatgcacc atattaacgg ttttctacaa 2579641 gaaaatcaat tgctttgcga acttttaaat cttctttcat cgcgtcagta gaaccgatgg 2579701 cttgtttaat attttcaaca ggcatgttgt atgcttcagc catttttgta agctcagcat 2579761 caacttcctc atctgatact tcaaggtttt ccgctttcgc aatcgcctca agagtcaggt 2579821 tagattttac gcgtttttca gcatcttctt tcatttgctc tttaagcgca gcttcatctt 2579881 ggcctgagaa ttgagtgtaa agctcaaggt tcatgccttg catttgcaga cgctgttcga 2579941 attctttcag catgcggtca agctcagtgt cgaccattgc ttgaggcaca tcgatttcag 2580001 cattttcaga agctttcaga acaagctctt cacgcaattt agcgtcagct tcgttttctt 2580061 ttgcttcttc taaacgtttc tttgtttttt cagttaattc agcaagtgtt tccacttctt 2580121 catcgatatc ttttgcgaat tcatcgtcaa gctcaggaag ctctttcgct ttgatttcgt 2580181 gaattttcac tttaaacaca gctggtttgc ctgcaagatc ttcagcgtgg tactcctcag 2580241 ggaatgtcac ttcaacatcc ttctcagcac ctgcttcaag gccaactaat tgatcttcga 2580301 agccagggat gaatgaacca gaacctactt ctagagagta gttttcagct tttccgcctt 2580361 cgaaagcttc gccgtcaacg aatccttcga aatcaagaac aactgtgttt ccttcttcaa 2580421 cggcgccttc ttcttttaca acaagctcag cttgacgctc ttgaagggct tttagttcgt 2580481 tttgaacatc ttcgtcagtt acagttgtgt cgtctttttc aatgcccagg cctttgtatt 2580541 cgccaagctt cacttcaggt tttactgtta ctttcgcagt gaagattaag ctttcgcctt 2580601 tttcgatttt ttcaacatcg atttcaggac ggtctacagg ctcgattcca gcttcttcaa 2580661 ccgctttagg gtattctaca ggaagaagaa tatccaaagc atcttggtaa agagcttcta 2580721 cgccaaagcg ctgttcgaat aatccgcgag gaattttacc tttacggaat ccaggaattg 2580781 aaacttgttt tactactttt ttaaatgcat catcaagtgc tgttttaaac gtttcagcat 2580841 caacttcaac cgttaaaacg ccttcgttgc cttcttgttt ttcccatttt acagacatgt 2580901 gtttccctcc aaaaatctat tcaggttgtg tcggtcttcc attctaaagc aatcattcgg 2580961 cttcgtccaa caaaaacaaa gctgccaaag atcagaatca ttatgtatag atgttaataa 2581021 tgaactgcaa agcctgtcca accgtatttc ttataacccg ttatacacaa atacaaccac 2581081 tatattataa cataacacat agcgctttca actatatggc gcgatttaca aataagaaat 2581141 ttcttcaata tcttttaaca ttgtgcaagc ttcatcgagt tctctgtctg taaattcata 2581201 catcatatga agttcttcgc tttcaatttc aatcccgtgc atctcgtaac cgactttatg 2581261 aagggcagcc gcccaaaggt cagccgacag caatttcggc tggaacggat ataaaacgta 2581321 caaatgtctt ctccacaatt cttctactgc tgcatataag gttggatttt catttccaag 2581381 tgtctcatct agcaccctga gaacacggtg aagaatcggc gcggcatcag gcggaacaat 2581441 ctctgacggt tcaattgtca acgactcgcc aaatttacta atgtgtacag gtttactgta 2581501 ctcatgctca gccaacagca tgacaatcat cgttttgata atcggatggg ctgaggggtc 2581561 ttggaggatt gttttgagca atcctgtata ctttgctacg ttacggtctt ttaaggaatg 2581621 aatgagattc atttgctcct cagggcttgc cagcactttc tcggtgtcaa ttgtatcctc 2581681 atattcttcg gcccaagcct cgtcctcacg atccggatcg gtcattttcc ggctgaaatc 2581741 cagcagctta taaaattgct cggcactttc tgccggcagc tgattttctt ccaaaacggc 2581801 ttcaatggtg cttttgactt cttcgtactt tttgagctga attaagatgg tcatgtacac 2581861 ctgcaaaacc gtaaaataat ggccataacc ttctttgagc atcttctcgc acacgctttc 2581921 tgcctcttcc agctcgccca gctctaaaaa gcagatggcc atccctaagt gaagatcgga 2581981 ttcagtatca tcatatttca tcgcttctga aaacagttca agcgcttctt gatacttttt 2582041 ttccttgagt gatgacatcc ctttttccac aaggcggtct ttcagatgag gaaaaggaat 2582101 aatttttgcg tttttcttgt catgcgtcat acctatattc ctttcaggca tttattttgt 2582161 tcaagtgtat caacacctgt gaacaaaaac aagaaatgaa aggtttcacc aggcaaaaaa 2582221 agccgccgga caaataccgg ccgctttttc aggcttgaag ccaagagctt ctttgtgatt 2582281 caaattgctt gatttcatct tccagcagca gcgttaatga aatttcatca tatccgttga 2582341 tcagcatctc tttccaatgc ggatcaactt caaatgaaat ttgattgcct tcactgtcat 2582401 gaatcagctg attttcaagg tcaacagtca tttgcaatga ctggttttca tactggccga 2582461 caagctgttt ccaattgtca tatggcatgc ggatcggaag catgccgttt ttaaagcagt 2582521 tctgatggaa aatatcagcg aatgacggcg caatgataat tttaaaccca taatcatcaa 2582581 gtgcccacgg agcgtgttca cgcgatgacc cgcagccgaa gttttctcct gctattaaaa 2582641 tggaagctcc ttgataaaca ggctggttta attcaaattc agggttcggt tcaccattcg 2582701 catcatatct ccagtcaaag aatgcaaaac gtccgtagcc tgttctttca atcctcttca 2582761 aaaattgctt aggaataatc tggtctgtat ccacattgat ccgatttaat acggctgctt 2582821 tccccgtatg tgatttcaaa ggttccatct cgcgcactcc ttacacaact gttttttcct 2582881 gataaaactt tctgacatca acgaagtgtc cgtgaatggc agccatcgca gccattgccg 2582941 ggctgacgag atgtgttctt gcaccttttc cttgtctgcc ctcgaagttg cggttagagg 2583001 ttgatgcaca gcgctctccc tcaggaacaa catcattatt catactcaaa cacatgctgc 2583061 agcctgactc tctccattca aatccagctt ccaagaaaat ctggtcaagc ccttcttttt 2583121 cagcctgaag cttcacgctt tgggatccgg gcacgacgat ggcccttacg ctgtcagcta 2583181 ccttcttccc tttgatcatg tcagcagcct gtcgaaggtc agtcatgcgg gaatttgtgc 2583241 aggaaccgat aaatacgtgc tccactttaa tgtcttcaat tttttggtga ggagtcaatc 2583301 ccatatattc ataagcacga atcgcttctt ttttatcgtc ttctgcagaa aagctttccg 2583361 gcgcaggaac ttcagaatcg acaggaagaa ccattcccgg gttaatgccc catgtcacca 2583421 taggggaaat tttgttgccg tcaaggacga tagatttatc gtaaacagcg cccgggtctg 2583481 tgcgcagcgc cttccattcc tctacggcct tgtcaaattc ttcgcctttt ggcgtgtact 2583541 tgcgattttt gcaatattca aacgtcacct cgtcaggtgc aatcaaacct gctcttgctc 2583601 ctgcttcaat tgacatgtta caaacagtca ttcgttcatc catcgtcata tttctgaata 2583661 cttccccagt gtattcaatg acgtagcctg tgccgaattt cacaccgtat ttgccgatga 2583721 cagcaaggat gacatccttt gccgttaccc ctttttgaag cgttccatct acgcgcactt 2583781 caagtgtttt tggacgctgc tgccaaagtg tctgtgtgga aaggacatgt tcaacttcac 2583841 tcgtcccgat tccaaatgca agagcgccga aagcgccatg tgttgatgta tgactgtcac 2583901 cgcacacaat cgttttccct ggaagcgtta agcctagttc aggtccgacg acatggacaa 2583961 tcccttgatc cacactgtga agatcggcaa ggcgcacgcc aaattcctca cagtttcttt 2584021 caagcgccgt tacctggcgt ttcgcaactt catcctttat ctcaaaacga ttgacagtcg 2584081 ggatgttgtg gtccattgtc gcaaatgtgt tttggggtct tctgaccttt cttccctttt 2584141 gtctcaagcc ttcaaatgcc tgaggagacg tcacctcatg aatgaggtgc aaatcaatat 2584201 agagaagatc cggctttccc tcaccatgtt ttacaatatg ctgatcccaa atcttttcga 2584261 tgattgttcg aggcatcatc ttttatttcc tccctctacc tagagctaag accgcttaac 2584321 gtaagctgtc acacattaga aattgtattt tcactcatga ttgctgcctt aacttcctct 2584381 gtaatggcct gagtgctgct gaactcttca ctccgtgcca agtctcttgt tctttttcca 2584441 gaagccaaga ctttgtttac cgcatcttct acagctttcg cttcctcttc aagcccgaaa 2584501 gatgttctca aaagcattgc cgctgacaat atggctgcga acggatttgc catcccttta 2584561 ccggcaatat caggcgcgga gccatgaaca ggttcaaaca gatgaaggcc agagcttgat 2584621 aggctggctg acgggagcat tccgagcgag cctgtaagca tggacgcttc atcgcttaaa 2584681 atatcaccga acatattttc agtcaccacg acatcaaatt gattcggtgc ataaattagc 2584741 tgcatggccg cgttatccac aagcatgtgc tcaagcttca catcaggaaa ttcttgtgca 2584801 acgtcctcag ccacttcacg ccacagccgg cttgattcaa gaacattcgc tttatctaca 2584861 gaggtcactt tgccttttct ggctgccgcc attttgaagc cctctctgat cactcgttca 2584921 atttccgttc gcttataaaa cagtgtatct actgcttcct gctcaccttc agtgtttaca 2584981 taacgtttgc tcggctggcc gaaatacaag ccgcctgtga gctcacgaac gataacgaaa 2585041 tcaacattat ctatatattc ttttttcaaa ggcgaagcgt cagaaaggct ttcaaatacc 2585101 ttcacaggcc gcaaattcgc aaacaaatca agctgttttc tgatgctgag cagccctttt 2585161 tccggtctca gttccgaagg attttgatcc catttcggtc cgccgacagc accaagcaat 2585221 atcgcgtctg catttttaca agcagcaacg gtttcctccg ggagggggtt atgatgttca 2585281 tcaatagccg cccctccaat caggccatat tcaaattcaa attcatggtt aaagcgttcg 2585341 gcaacacttt tcagtacgtc tgtcgctgat tctaatactt cagggccgat cccgtctccg 2585401 ggcaatagag caatacgttt cttcaagtta accgttctcc tttcttttat gatccgacag 2585461 ctgtgtggtt tttcaatccg ctcatattcg actggaaaac caattgacgg tttactgcgt 2585521 tcaaataggc tttcgctgat gcttctaata cgtcttgcgc tatgccccgc cctgctgatt 2585581 cttttccgtt caccaaaact cttacataca cctgggcaaa tgcatcttcg ccttttctat 2585641 tagactgaat gcggtagtct aagagctcca catccttatc gatgcagcgc tcaagcgtat 2585701 tgtagattgc ttccacgctt ccagctccag ttgcagcttc ctgaataagc tgtgcgtttt 2585761 cttgattttt caaagataga gtagccgtag ggacctgact tgttccgtaa tgtacttgca 2585821 gagaaagaaa ttcataccca atcttgcgat ctgttacttt ttcttctaaa ataagagaaa 2585881 caagatcctc atcagtgatt tcttttttct tctcagtcaa ctctttgaac atcgtaaaga 2585941 atttattaat ctcttcactg tcaaattgga atcctaaagc agtcagccgg tctttaaatg 2586001 cgtggcgtcc ggaatgttta cctaggacaa gcgcatctgc ggttacgccg acaagctccg 2586061 gtgaaataat ttcataagtc gatttttcct ttaaaaagcc gtcctgatgg atgcctgatt 2586121 catgagcaaa tgcattatct ccaacaaccg ctttgttgcg cgggacagcc atgcctgtca 2586181 gtttgcttac taaatcactt gttctcttaa tctcgttcag cgtaatacct gtttcgactt 2586241 ggtagaaatc ttttctggta tggagggcta cggcaatttc ctctaatgcc gcgtttccgg 2586301 ctctttcacc gatcccgttc acagcgcatt cgatttgatc agcgccattt tcaatcgcag 2586361 caagagagtt tgcgactgcc attcccaaat catcatgaca gtgggctgaa agctttgctt 2586421 tgtgaatgtt cggaacgttt tctttcatat atttaaagat atttccgtat tccgccgggg 2586481 ccaggtagcc gacagtgtcc ggaagattga taacactggc gcctgcgtca atcactttct 2586541 cgacgatttc tgctagaaac ggcagttcag tgcggcaggc atcttcagct gaccattgca 2586601 caatcggaaa acgttctttt gcgtatttca ccattccaac tgctctttca atgacttgtt 2586661 cacgtgtcat tttcagcttg tgcttcaaat gaatgtccga tgtcgcgata aatacatgaa 2586721 ttcttggttg agcgccatcc tttaacgctt cccaagcagc atcaatatca ccttttacac 2586781 aacgggccag accagttact gaacaatttt taatggttct tgcgatttcc tgaacagcta 2586841 aaaagtcacc tcgggacgaa gcgggaaatc ccgcttcaat gatgtctgcc ccgagtcttt 2586901 cgagctgctt agctatggca agtttctcct gtgtattcaa gttcactcca ggggactgtt 2586961 caccatcacg aagcgtcgta tcgaaaaaat taattttgcg caacggagac caccgcttcc 2587021 ttcttcttgc cttgtttcac aaacggcatc atttcacgaa gctttcttcc cactacttcg 2587081 atttgatgtt cgttctcgct tgcattgata gcgttgaaac gaggacggtt tacttggttt 2587141 tcgacgatcc actcttttgc gaatgtaccg ttttggatat cttttaatac ttctttcata 2587201 gattctttta ctttggcgtc cacaacgcga gggcctgata cgaaatctcc ccactgtgct 2587261 gtgtcagaga ttgaatatct cattcctgca agtccttctt cgtacataag gtctacgatt 2587321 aatttcagct catgaagaca ctcgaagtat gcaagttcag gctgataacc tgcttcagtt 2587381 aaggtttcaa atccggcttt gacaagcgcg cttaatccgc cgcaaagaac tgcttgctca 2587441 ccgaacaaat ctgtttctgt ttcttcttta aatgtcgttt ctaatacgcc cgctcttgcg 2587501 ccgccgattc ctttagcata agcgagggct ttgtctcttg cttctccagt cacatcttga 2587561 tagattgcga acaatgcagg tacgccagct ccttgctcat atgttcttct taccaagtgt 2587621 cccgggcctt taggggccac taagaataca tctacatccg ccggaggaac aatttgatgg 2587681 aaatgcacgt taaatccatg agcgaatact aatgattttc ctgctgtcaa ttcatctttg 2587741 atttcagctt cgtatacttt ttgctgctgc tcatccggaa gcagaaccat gatgatttcg 2587801 gcttgggctg ccgcttcttt tactgaaaat actttatgtc cgtcttcttg ggcttgagtg 2587861 aaagattttc cttgtctaac accgacgatc acgtctactc cgctttcttt aaggttcagg 2587921 gcatgtgcgt ggccttgcga accgtacccg ataaccgcta ctgtttttcc agccaatacg 2587981 ttctctttga tatcaccgtt ataatatact tttaccattt caatctctcc cttgttatgt 2588041 tttatacaat agatattgtt ttattggatg acgccttttg ctgggttccc ctcgcaaaag 2588101 ccgttgtacc tgttctcgcg atttctttaa tgccataagg ttttaataac tcaataagcg 2588161 cttcaatttt gttagattca cctgtcacct gaacaacgat gctgtctctg ctgacatcaa 2588221 cgacagaggc tctaaacggt tctatgattc cattaatctc tgttcttgtt gaaggtgcgg 2588281 agacaacctt gattaaggcc agctccctct ggacaatcga ttgatttgtg atgtctgtga 2588341 ctttcagcac atcaatctgt ttgttgagct gtttcgttaa ctgttcaaca tcattttcac 2588401 cttcaacatg aacgacgaag gtgattctgg aaacgccggc tgtttctgtg tgtccaactg 2588461 taatgctttc aatgttgtaa tgcctttttg tgaatagacc ggtgatccgg tttaacaccc 2588521 cggagcggtt caccacagtc aatgtgataa ttcttttcaa ggtttcaccc ccaccatttc 2588581 atgcagccct ttccccggag ccaccatcgg gaatactttt tcttcgctgg caacccgcac 2588641 gtcaatgaca acaggttctc ttgatgttaa tgcctcttcc agcttttcct ttgcttccgc 2588701 ttctgatgaa attctgatgc ctttaatgcc gtatgcttcg gacaatttga cgaagtcagg 2588761 ctgagaagcg aatttagatt ctgaataacg ttcttcatag aaaatttcct gccactgtct 2588821 gaccattccg agacaagcgt tatttaaaat cactaccttg accggaagat ttaattcgcg 2588881 aataacatcg agttcttgaa gcgtcatttg gaatccgccg tctccgacaa ccgcgacaac 2588941 agtagcatct ttttcggcca gctgtgcgcc gatcgccgcc ggaagaccga atcccatcgt 2589001 tccaagtccg cctgacgtga cccatttatc tgctttttgg aacggataaa attgcgctga 2589061 ccacatttga tgctggccta catccgttgc gacaatggcc tctccttttg taaattgatg 2589121 aatatattca atcaatttct gaggtttaaa accttcttct tcattatcta cataccagag 2589181 cggatactct tctttccatt ctgcgagctg ttttttccat tcgcttgaat cgctttgttt 2589241 gccgtcttgt ttgatcagct cctgcaggac aattttgctg tctccgacta caggaatctg 2589301 tgttttcatg atttttccga tttcagctgg atcaatatcg atgtgggcta tctttgcgtt 2589361 tctggcaaag tgtttcaggt ttcctgtgac acggtcatca aaacgggcgc cgatactgat 2589421 taatagatca cattcatgaa gggccatatt ggctgtataa gtaccgtgca ttcccgccat 2589481 ccctaggaaa agcggatggt cagccgggaa gcctccgagc cccaaaaggg tgtgtgccac 2589541 agggatttgc tgctgttcag cataattttt taattcttct gacgcttttc cgtgcagtac 2589601 gcccgcaccc gccaggatca ccggtttttt cgcactgctc acggcttcca caagcttgcg 2589661 gatctgcaaa taattcggct ctgttgtcgg ctggtatccc gggagattca tctcatgatc 2589721 gtagctgaat tctccttcaa ttgttgctac atctttcgga atatcaatca atacaggtcc 2589781 gggtcttcca gttgttgcaa tatggaacgc ttctttaatg atgcgcggca gatcttccgg 2589841 ctggcgaacc tggtagctgt gttttgttac tggcatcgta atccctaaaa tgtctgcttc 2589901 ctgaaatgca tcgctcccga ttacagaggt tgctacctgc cctgtaaaga cgactaacgg 2589961 caatgaatca atcatggcat cagcaaggcc tgtaacaagg tttgtcgctc ccggccctga 2590021 cgtggcaatg acgacacccg gttttccgga gacccttgcg tatccctccg ctgcatgaat 2590081 tgctccttgt tcgtgacggg gaaggatatg taccaaccct gaattgtata gcttatcgta 2590141 aatcggaagc acagccccgc ccggataacc gaagatcatt tctactttct ctttttttaa 2590201 tgattcaatc agcattaatg ctccgctcat cgtctgtgta cattcggcag atgctgaatc 2590261 cacctgtaca ttagtcccca ttttagttcc tccttttgga ttttcatcct ttaaagatca 2590321 tcttttcatt agctagatag ctgattattc aataaaaaaa gcccttccgc ccacaatcag 2590381 ccgcgcagta actgcgatag ctaaaagggg cgaaaaggct tttctttccg cggtaccacc 2590441 cttgtttacg gcctgttaat cggccgtctc atggatattt ctatccgctt tagtaacgag 2590501 tgaatcaagt tcacccggcc aagtcctact gtcatttcag actggcactc tgaggcgagt 2590561 tcaccttgta aagcttcgcc ggttctcagc taacccggtt ctctgtggaa aactttatca 2590621 aggctactta tcctcatctg cgcttttcat attcagcctt cggaacggct ttccagctgt 2590681 tcaagaaggt cgtttgtttt tcattttttt agaatcatac tgcgatgatt ttcgcttgtg 2590741 aagcttgcat ttatcttttg ttgaactcat attacgccgc tttggacgca gtgtcaacag 2590801 cattttttaa aattattaga caattttgat taatcaatct atattgtata cgctttcatt 2590861 attggtacaa aaggaattgc aaatgttaaa agtttttata atttttttat taatctatca 2590921 agaatacacc agaattattt aattttatat aaacatggaa gattttataa cacgatatgg 2590981 ttcgtatatg gattgagtct gacagatcat cttgcaatcc atttcaattt cggataggca 2591041 cttctcttgt tccctcggca tacattaatg atatcttgca aagaaaaggt gatacgatga 2591101 ataaatcatt tgcagacatg caaggatttc ctgcgggctt tccaagcttc cccaactttc 2591161 cgcagcagta ctatcctgct gtccctccct tttaccagca aagccagcag ccatttggag 2591221 gctacggata cggacagccg ttcagtcagg catacagccc gttaaccact ccctctggaa 2591281 tgtactcctc attcccatac gcttcaggat tttacggaca gcaattttca ggtgcaggct 2591341 ttagcggcca tggcggcagc ttaagtgctc cagcgataca tgccggcgga ttcagcgggg 2591401 cgccaggcgt acacggaggc tttagatatt aaagaatacc acaagggccg aacatctatt 2591461 gcggtccttt tattgtttta aaacgacttc acaagtacag tcacattttc tgtctttata 2591521 tttggaaaca ggatggaata tgattaagat gaattgaacg atattctgca caatccgtaa 2591581 gttttcgagg aggaataaaa ttgcatataa aaatagacga tttaactgga cgtcaggtgg 2591641 tttcactggt gaatgagcat ttacatagca tgacgcttat gtccccgcca gaaagcattc 2591701 atgccttagg tctagaaaaa ctaagagggc ctgaaataac attttggagc gcatgggaag 2591761 gtgatgaact agctggctgc ggagcgctaa aagaactgga cacccggcat ggagaaatca 2591821 aatcaatgcg aacatctgca tcacatttaa gaaaaggcgt tgccaaacaa gttctccagc 2591881 acatcattga agaagccgag aagcgaggct atgagcggtt aagcttagaa acgggttcaa 2591941 tggcttcatt tgagccggca agaaaattgt atgaaagctt cggtttccag tattgtgaac 2592001 cgtttgcaga ctacggtgaa gatccaaaca gtgtgtttat gacgaagaaa ttgtgagacg 2592061 gctttataag gatagataag tgcaggggaa ggtctgtctt atctatcttt ttttatattc 2592121 acacattttt cacctttatg atacacgcca atgttttcaa ttttgtttaa ttcaaagaac 2592181 agcgggaatt acaaacgaca tgaacgatat catgcaaatt cataaaggag gagattgata 2592241 tgaaaagcat agttggtgta tatgaaactc cgcaggaaac catcgcagcg attgaaggct 2592301 tacttacaaa aggctatgat tctgatgaca tttctgttgt gacaagccgg cgagatacag 2592361 attatttgga gtcacgtaca ggaacagaag tcaatcaagc tatcgatgca catcaggacg 2592421 aatctgaatc ttttttcgat aaactgaaag attatttcac aatggatgat actgctacac 2592481 acagcaaagc attatccgac ttggatatta aaactgatga aatagacaag tatcaagaag 2592541 atttggatga cggaaaactt ctggtagccg tcgatacaga tgcagatgta attgctccta 2592601 ttgataacgg caatgccctt tcaggcggct tttcaagcac aaatgaattg gattatacaa 2592661 cgaaagaaga aaaaacgatg ccgctccggg aagaacagct gaaggtcgat aaggaagacg 2592721 ttcaaaccgg cgaagtagaa ataggaaaag aagtgaaaac agaaaaaaga gatatggaca 2592781 ttccggtgag acatgatgaa atttatgtcg aacgccgtcc agtggatgaa aataaaacgg 2592841 acgctgctcc cgtcaacgat tcggaagaga tcagagttcc aatcgttgag gaaaagctgg 2592901 aagtgactaa aaaaccggtt gtcactgatg aagtggttgt cggcaaacgc actgttgaag 2592961 aaaatgaaca tatttctgaa actgtgaaaa aagaagaacc tcgtctgaat aaagaaggaa 2593021 aagttgacgg cttggatgat gatccgttaa ataacaaatg aaaatcatag accgacaaca 2593081 aaaaacctca aatcctaaat ggatttgagg tttttctttt ggtacgtccc aggagagatt 2593141 cgaactcccg accgacggct tagaaggccg ttgctctatc cagctgagct actgggacac 2593201 gttttgtttt tttgtttttc gctttaacta tcagcgacaa gatttattat atatgggatg 2593261 caataataag tcaacggttt tttagaattt ttttcatgag gaagaaaatt ttcttcctca 2593321 tgacattttc atagtgtgac tcgattttgc agatcctcaa tttcattgcc tgcttggtcg 2593381 taaaaacgga ctgtcgcagc atcattttct aatgtcagta tagcatagct ttctgtcctg 2593441 cgcaccctcg gaagccggat gctgcctggg ttaatcatca gttttccgcg cagcacttcg 2593501 cttcccgcga tgtgcgaatg cccgaagcag ataacatccg ccccgagctc ctctgcacga 2593561 tagtatacgt ttaacaaggt ctgttttata ccgtgaaggt ggccgtgtgt gactagtatt 2593621 tttcttgagc cggcagtcag aagaagctcg tccttaaaat cgccggcaaa atcgcaattg 2593681 ccttttacaa ccgcataagg ctccaatgca ggatgcctcg tctcaagctc agagtccccg 2593741 caatgaatca tgagatcaac ttctgcctca tgccgtttcg caatggtttg gagttcttct 2593801 tcaagcccat ggctgtcact gataatcagc acgttcatgt acaagcttcc tccttatgcc 2593861 tccaaaagct tagacagctt tttaagcgcg tcagccctat ggctgatttt atttttttca 2593921 tcacttgtca gttcagccat cgtcttatct ttatctttca cgataaaaat tgggtcatag 2593981 ccaaagccat attctcctct cggttcttca gcaatatacc cttcaacatg gccttcgact 2594041 gtttttgttt cctctccggg aatactcacg gccagtgcgc agcggaaacg ggcggtgcgc 2594101 tgttcttttt cgataccttt cagctcgctg agcacttttt cgatatttgc ctggtcgtct 2594161 ttctgttccc ctgcatagcg ggctgaataa accccgggtc tgccgccaag attatcgatg 2594221 gatagtccgg agtcatccgc aatcaccatt ttgttcactg ctttggcaac agcttccgct 2594281 ttcataatgg cattttcttc aaatgtatgg cctgtttctt caatttcctc tgtgaatcca 2594341 atttcagcta aagatttgac atcatagcct cttggctcaa gaatttcttt gaattccttc 2594401 acttttcccg gattatgtgt tgcaataatt gcttctttca tgatgatcaa gcctttctgt 2594461 ctttatttca gttctggcag agaatcaccc agcacttctt tttgcttgtc aatcagctct 2594521 tggattcctt tttccgcaag acccagaaga ccgttcagat cctctctaga aaaagttgcc 2594581 tcttccccgg ttccctgcaa ttccacaaaa cggccgctgc ctgtcatgat gacattcatg 2594641 tcaacttcag cagaggaatc ttcttcataa tttaaatcta acaaaattcc ctgttcctta 2594701 tcaattccaa cagagattgc agcaagaaaa tcagtgatcg gatttgtctt gattgttcct 2594761 gctttgatca gcttgccaat cgcaatcgcc atagcaagaa atgcgcctgt aatggaagct 2594821 gttctagttc ctccatcagc ttgaatgaca tcacagtcaa tccaaatcgt ccgttcaccg 2594881 agcttttcca gatctacaac agctcgaagc gcgcggccga tcaggcgttg gatctccatt 2594941 gttctgccgg aaattttccc cttagaagat tctctgattg ttctttggtt tgttgcccgc 2595001 ggcagcatgc tgtactctgc tgtaatccag cctttccctc cgccccgcaa aaacggcggt 2595061 acgcggtcct caacagacgc gttgcagatt acctttgtat ttcccgctgt tattagaaca 2595121 gaaccttccg gatggctgat aaaatccaaa tcgaatgtga ttggacgcag ctcatcgtgt 2595181 tgtcttccgt catgtctcat gttttacctc cgattgtatg tacataaacc atttttgtcc 2595241 cggaattgaa taaagaaaga ggcagccgga acgctaacct ctttcttcct agtatatcaa 2595301 aaatcccaat ttaaaaacta cccgtattca cttgagatgg tctggagacc ggttctgtga 2595361 gcttttcgcc tttttcattt accagctctg attttccgtt cactttaaca gagacgcttt 2595421 ttacatccgg ctgctccgtt aacgtcagca caatgctgtt cagcacttct gaagaaatca 2595481 ttttcgtctt ctcatcggcg ctgccgaata tagattgatt gaaatccaac gtcacgcgcc 2595541 cgtctttgat tttcggtttg ctgaccagct ttacatcttc actgaagtct gttaacagcc 2595601 cgctcacctt gctcggccct ttagccaatt cattaatggc tgctgtgatg tcgtcttttt 2595661 ccgaattgtc gattcgtttg gtcaccggca cgtagtattc actgtcttca ttttccgcca 2595721 aatagtagac tgtcagcgga tgggtagcag tgagatcatt tacaccggct gtttccaaat 2595781 taatgccgtc tttgcggctt aaatcatctg agatcggcgt ccctcctaca ggcatctcct 2595841 tcagttcatg cccgtttatt ctcagcttca ctttatctat cgaactaaat tgcgtcagcg 2595901 tccacgtcac agattgaacg attttctgtt cgtcttcttt cttataattt ttgaactcat 2595961 tagagaaatc agctatcgcc gttccatctt ttttgatgtc aacgttaacg gtggtgtcag 2596021 ccggcaatac agctctgaag ccattcggaa gaatttcaga cacaggcccg ccctgtacga 2596081 ggtattcaag cgcctgctta gccgtgctct cacttttagg aagaggcagc gtttgcgcaa 2596141 caacataccc gtttttatca atgagataaa gctccctcat aacagtagat gaggcttgat 2596201 ccgcttttgc ggtatcgctt ttttcacttt ctgttttttt ggctgctgtt gtatttgaat 2596261 tggcacccgc ttcatcgttc acgaatgtaa cgtcttgagg cggatcaatt tcctcggctg 2596321 ccttatcaga ttgaaacaaa ccgcatccgg ataaaagcaa ggcagaggtg agacaagtgg 2596381 caccaatgac tgcaggtcct tttttcagca tacttttccc tcctaaggat gtttgtacta 2596441 ttatgtatac gagcctcttt aggaaataga ccgaagaatt ccggcaaaac agaaaaaaac 2596501 ccgcaacata ccgttgcggg gaaaactatc ttttaatcgg ttcttgcagt gagatacatt 2596561 ccacatgccc gacttcatgg ccaaaccaat cgtctgcgat ttttgcaaac tgatcacgcg 2596621 cccctgttgt caggaactga tgatccgggg caatcggaga ctggttcagc agccctttat 2596681 aagagagaat tgtgctgact tcccgggctg tttcatcgcc ggacgaaata atgtttacgt 2596741 gctctcccat atatctttga atggcttctt ttaaaatagg gtaatgggtg cagcctaaaa 2596801 tcagcgaatc aattgatgtg tcttttaacg gatacagcga ggttttaaca atctcgtctg 2596861 ctgttttgtc gagaaacttc ccgctttcca caaaaggcac aagcagcggg caggcaaggt 2596921 tttcaacctt caaatcaggg tttaatgcca aaagcgcttc ttcgtatgca ttgctcttaa 2596981 tcgtattctc tgtgccgatg acaccgatat gctgattatc cgtcactttt atcgctgctc 2597041 tcgcaccagg ctggatgact ccgaccaccg gtataccgac gctgcgctgg atgtcatcca 2597101 aagcgatcgc tgttgctgta ttacaggcga tcacgagcat tttgatgtgg tggttttcga 2597161 gtaaataatt cgtcagctcc cacgtatatt gaagcacctc ttcttcaggg cgcggcccgt 2597221 aaggacaccg tttcgtatcc ccgacgtaga taatattttc tttaggtagc tgtctcatga 2597281 tttccttcgc aacggttaaa ccgccaaccc cggaatcaat gactcctatt ggttgttcca 2597341 acaaaatcgc ctcattttct cttcatttca tgctgcagtt tcatcaaaga tttttcgaag 2597401 atggctattt cttcatctgt aaacgattcg aacatatcac gcagatattc ctgtcttttt 2597461 gtaatgacct cttggataat ccgttctcct tcaggcagca gatgtatcct gacaacacgt 2597521 ctgtccgccg ggtccttgac ccgctcaaca agctcatttt tttgcatgcg gtcgattaag 2597581 tccgttgtcg tgctgcatgc cagatacatt ttgcccgata attcaccgat tgtcatatct 2597641 cctaattcat aaagccattg caagccgaca aattgcggcg gcgtaatcgc atattggtta 2597701 aggatttctc gtcctttttg cttaatgatc gcggcaatgt ggcggagtga cttttcaata 2597761 tccgcaacat gctccaaagg ttttgatgtc atttgtccat ccctcactca aggatctctt 2597821 acgcacaaaa gcgttccgtg tctattttcc ttcttttttg aagaaaatgc aagactcgca 2597881 ggagagaaat agaggacttt agtcaaacaa catcaagaaa taaaatttaa tttatgactt 2597941 gcctacgttt tgcacagcat tccaaatatg gtttcgaatg ttccaaacaa acagcaataa 2598001 ccggctcctt ccaaaagaag gaataccggc aaggattaaa gctctagctc acccattcta 2598061 agaagctcaa caacggcttg cgaacgccct ttcacaccca atttctgcat ggcatttgaa 2598121 atatggtttc gaacggtttt ctcactgata aatagctcgc ttgcaatctc ctttgttgtc 2598181 ttatcttgaa cgagcaattc gaacacttct ctttctcttt tcgttagcag cggcttcgat 2598241 tgaaattctt tctccttcaa gtattgtaac cctccttgct aaggtgagag cgaatcagaa 2598301 acgaatgggt tttgatatag tcgagatatc atatgtaaga agggcgcagg aggtgacgtt 2598361 tacaagataa ttagtttatc gtgtatgaag aagcgtttct ttctcctcat ccgtccagct 2598421 gacagccttg ccgctttcct ttgagacttg aaccatcacg actgccccgg tgaagcaggg 2598481 ttcgccttcg aggttctctc cgagatagtg caaggtaaga gatgaactgc cgactgcgct 2598541 tgttttcaca tagatgcgca actcttcata aggcatgact tggcgcaaat aatcgcattg 2598601 ctggcttgcc acgactgtca tggtctgttt gttttcactc atcatattca gctttttaaa 2598661 ataagaaatc cgcacctcct caaaatatat aaaaggggtt acattattca tatgcccaaa 2598721 catgtctgtc tcggaaaatc ttacggatac cttattgaaa aaagaaaagg atgttttcca 2598781 ttcttgaaac ggcatatcaa tataagcggg aagcttcatc ttttttcatc tccttattgt 2598841 ttaaaaaaac ctctcccatg cggaagaggt tttttcttct tatactctgt cgcttccgaa 2598901 gaaattgcgg aacgcttgta agtttgtatc tctattcaag gctgcaatcg aagtggtaag 2598961 cggaatcccc ttcggacagg attgaacaca gttttgcgag ttgccgcaat ctgcaaggcc 2599021 gccttcatcc attaatgctt ctaatcgttc agatttattc atggcgcctg tcggatgcgc 2599081 gttaaacagg cggacttgcg acatcggtgc aggccccatg aacttcgatt tgctgttcac 2599141 attcgggcaa gcttcgaggc agacgccgca tgtcatgcat tttgataatt catatgccca 2599201 ttgacgacgt ttttccggca ttctcggccc cggtcctaaa tcgtacgtac cgtcaatcgg 2599261 tatccacgct tttacttttt tcaatgaatc aaacattctg ctgcgatcaa cctgcaaatc 2599321 acgaacgact gggaatgttt tcattggttt taaacggatt ggctgttcaa gctggtcaat 2599381 aagcgccgta caagactggc ggggttttcc gtttataacc attgaacatg cgccgcatac 2599441 ttcctcaaga cagttcatat cccatgtgac aggggttgtc ttctcacctt tgacattaac 2599501 cggattccgg cggatttcca tcagagcgga aatgacgttc agattcgggc ggtatggaat 2599561 ctcaaattct tcatcataag gcgtgctgtc agctgtatct tgacgtgtga taataaatcg 2599621 tatggttttt tgttcactca tgattatttc gccaccttct tcttcgagta atcccgtttc 2599681 cgaggcgtta tcagtgatac atcgacatcc tgatactcaa attccggcgc ttcatacggg 2599741 cttacatgtt tagccattgt tgttttgagc cattcatcat cattacgttc aggataatcc 2599801 ggtttataat gggcgccccg gctttcatta cggttgtatg cgccaagggt aatcaccctc 2599861 gcaagctgaa gcatgttcga gaactggcgt gtgaacatcg ctccctggtt gctccatttt 2599921 gtcgtgtcat tgatgttgat ctttttgaag cgctccatta actcctgaat tttgtcatcc 2599981 gttttcaaaa gcttgtcatt atggcggaca accgttacgt tcgccgtcat ccactcaccg 2600041 agctctttgt gaagaacata ggcattttcg gttccgtcca tactcataat atcagcccat 2600101 ttttcttctt ctttcttaac gtgagcgtcg aataaagatg aagacatgtc ttccgctgaa 2600161 gattctaagc cgtttacata tttcaccgca ttcggaccgg ccaccatgcc tccgtaaatc 2600221 gcagacagca gggagttcgc tcccaagcgg ttgccgccgt gcatagaata atcacattcc 2600281 ccagccgcaa acagtccagg gatatttgtc atttgatcgt aatccaccca taaaccgccc 2600341 atagaataat ggaccgccgg gaagattttc attggaagct tacgcgggtc gtctcccatg 2600401 aatttctcat aaatctcaat gatgccgcca agcttaatat caagctcttt cggatcttta 2600461 tgagacagat cgagatatac catgttttca ccgttaatac cgagcttctg gttcacacac 2600521 acatcaaata tttcgcgtgt cgcaatatca cgcggcacca ggtttccgta tgccggatat 2600581 ttttcctcca ggaaatacca tggtttgccg tctttatatg tccacacgcg cccgccttca 2600641 ccacgcgctg attcactcat cagtcttagt ttgtcatcgc ccggtatggc tgtcgggtgg 2600701 atttgaatga attctccgtt tgcataatac gctccctgct gataaacgat tgacgcagca 2600761 gatcctgtat taatcatgga gttcgttgat tttccaaaga tgattcccgg tccgcccgtc 2600821 gccataatga cagcgtctga acggaaggat tcaatttgca tgtttgtcag gttttgtgca 2600881 acaattccgc ggcaggttct gtcatcatct aaaacagcgc caaggaattc ccagccttcg 2600941 tattttgtga ccagacccgc aacttcgtat ctgcgcactt gctcgtccag tgcgtaaagc 2601001 agctgctgtc ccgtcgtcgc accagcataa gcagttctgt ggtgctgtgt acccccgaat 2601061 cggcggaaat caagcaggcc ttcaggcgtc cggttaaaca tgacgcccat ccggtctaat 2601121 aagtggatga tcgaaggcgc cgcttcacac atcgccttga ccggcggctg gttggcaaga 2601181 aagtctcccc cgtataccgt gtcatcaaaa tgttcccacg gagagtcacc ttcccctttt 2601241 gtattgaccg ctccgtttat gccgccttgc gcacaaactg aatgagaacg tttgacagga 2601301 acgatggaaa acaatttaac cgccattcct gattccgctg ctttaattgt cgccatgagg 2601361 ccggcaagac ccccgccgac tacgataatg cttgattgac tcatgatagc ccctctccct 2601421 ctagtaatct agtactctta aacaaatgca aaaatcgctt ttaagcctac gtatgacagt 2601481 gcaacaaaaa taatcagcgt aacgtatgtc gaaattcttt gagaacgagg cgttaccgtg 2601541 atgccccatg taacagcgaa agaccataaa ccgttcgaga agtggaaaat tgttgataaa 2601601 acaccgacaa tgtaaaaacc aagcatagcc ggagagctca aaatattcgc catcatgtcg 2601661 aaattgacct cagcacccat ttgtgcggca atgcgggttt cccacacgtg ccagctgacg 2601721 aaaatgaggg tgatgatacc ggttacacgc tgcaggacga atagccagtt tctcatgtag 2601781 ctgtattgac cggcgttatt tttcgcagta aacgctatgt acacaccata aactgcatga 2601841 taaattaatg gtaagaagat aataaaaatt tccaaggcat acctgaaagg caggctatcc 2601901 ataaaatgag cagcgctatt gaatgcttca gcgccccttg cggcaaactg gttgacgact 2601961 aaatgctgaa taagaaagat gccgaccggt atgacgccaa gcaaggaatg caatcttcga 2602021 aaataaaact ctctgttccc agacattact ttaccccctg tttgataagt gcgaaatgtg 2602081 ctaaatctct tcccccactt ctttcaattg taagcacttt attaagattt attgacaatt 2602141 tcattttact cctccctcaa aagggcgtca agaaaacgcg tacataaatt ataattttcc 2602201 gaattgatta gttgattgaa aaattttatt ttatcaatat atatttcttg cttaattttt 2602261 cataagaatt acaggatcat tctgtaatcc tcccccctgt ttgagctata atatacgcag 2602321 gagagagggg agacagatat gaagtctaaa tttgaagcat ctattgacaa cctaaaagaa 2602381 attgaaatga acgcttatgc ctacgaacta atacgagaga tcgttctccc agatatgctt 2602441 ggccaagatt actcttccat gatgtattgg gcaggaaaac atctcgcccg taagtttcct 2602501 cttgaatcat gggaggaatt tccggccttc tttgaagaag cgggctgggg aaccctcacc 2602561 aacgtaagcg ctaaaaaaca ggagcttgaa tttgaacttg aagggccgat catttccaac 2602621 cggcttaagc atcagaaaga accttgcttt cagctggagg ctggttttat cgctgaacaa 2602681 attcaattga tgaatgatca gattgccgaa tcatatgaac aagtgaaaaa gagagccgat 2602741 aaagtggttc tgactgtgaa atgggatatg aaagacccag tgtaatcaaa aaggcggtga 2602801 ctgcatagtc ccgccttttt gattgtcatt acacagctga agggtgtttt gaaagctcaa 2602861 atgcatcgtg aagcgactcg actgctttca ccatgtcatt ttcgcttacg actgttgaca 2602921 ctttgatttc agatgtgctg accattttga ttaaaatgtt tttttgcgcc agtacagcaa 2602981 acatttcagc cgctacaccg ggatttgaga ccatgccgga tccaacaata gatactttag 2603041 ccaatttgct ttctgtctcg attttctcaa attccagcgc gtctttatac tcttcaagca 2603101 ccgcaacggt ttggtctgca tcttctgttt tgacagagaa ggaaattcca gtcttgtcct 2603161 cggcctgcgt ttggataatg atatccacgt ttatgtttct tttggcaagt gttgtaaaaa 2603221 tagtagacaa agttgtcagg ccgctagtca gcccgtaaat ggttactctt gtgatttgat 2603281 cttcaaatgc aatgcctctg acaattaaat tctgttccat ggatgattcc tcctcaatta 2603341 atgttcccgc ttcggtttct gtacttgaac gcacttctaa cggcacttgg taatttttcg 2603401 cgaactcaac tgctctcgga tgaagaacac cggcgcctaa attggcaagc tcaagcattt 2603461 catcgtatga gatgccctca agttttctcg ctgatttcac atagcgcgga tcggttgtaa 2603521 acacgcctgg cacgtctgtg tatatgtcac atttatcagc ttttaaagcg gcagccaaag 2603581 caactgctgt tgtatctgaa ccgccccggc ccaatgtcgt aatttcacaa tcctctgtca 2603641 tgccttggaa tcctgcaaca atgacaattt ttcctttttc aagctggtct gctaaaaccg 2603701 aagtgtcgat atctgtaatt ctggcgtttc cgtgaatggc ctccgtacgg attcccgcct 2603761 gccagccagt ataagacaca gcgtcatagc ctttttcctg caatgccatt gaaaggagtg 2603821 aaatcgtgac ctgctcgcct gtcgccagca gcatatccat ttcgcgtttg ctcggctggt 2603881 cagaaatagc ttttgcaagg ctgaccaatt cgtcagtgga ttttcccatt gctgaaacga 2603941 cgacaacgac ttgatggcct ttctgttttt ctgcaattgc gcggtttgcc gcattttgaa 2604001 ttttttcgac tgagccgacg gaagtgcctc cgaatttttg tacaataaga cccatgtatt 2604061 accacccttt acattttggt tcgtgcgggt gaggagaaag agcgctttgt ccacaataaa 2604121 aaaagcaatg agaggaatac tctcattgct tatcaattaa tcatcataaa tgattatgaa 2604181 caacgagata gccctccaag aaaatgattt cttgacagcc ttacatttat tcaatgcacg 2604241 gccagcaaat aataccgatg gggttttatt tgcttcggcg acgctcccct ttcagccttt 2604301 ttcacagaat ccatctttct ccaaaggcat actcttgaag ttcgcacctc tatcttcacc 2604361 atataacacg atctaactat gaaattagtt cacattttat cagatcttat ttaaaaggac 2604421 aacattattt ttgcaatttg tcgtaaagga gctgagccgc cgctgcggga acaccggctt 2604481 ttttgatgtc ctcaaggctt gcttccttca tttttttaac ggaaccgaaa tgctttaaca 2604541 gcattttctt tcttttctct ccgatacccg ggatgtcgtc caaaacggat tgaaacgcgc 2604601 tttttccccg gatttgcctg tgaaaactga ttgcaaaacg gtgcacctcg tcctgaatgc 2604661 gctgcaggag gtaaaattcc tggctgtttc gttccagata cgccacctcc agcggatcac 2604721 cgatcagtaa atttgaggtt ctgtgttttt catctttcgc taaaccggcg atcgggatat 2604781 ccaagccgag ttcattttca atgacatccc ttgctgcgtt gatctgccct tttcctccgt 2604841 caatgataat cagatcgggc agcggcagat tctcacgaag cactctcgta tagcgtcttc 2604901 tgacaacctc tctcatagaa ccgtaatcat ccggccctgt aacagttttg attttatatt 2604961 tgcggtattc ctttttgtat ggtttgccat cgataaacac aatcatcgcg gaaaccgggt 2605021 ttgtcccctg tatatttgag ttatcaaacg cttcaattct gtgcggcgta taaatattta 2605081 atgcctcacc tagtttctgc actgccccga ttgaacgctc ctcgtcccgt tcgattaaag 2605141 agaatttttc tttcaatgcg attttcgcat ttttatgggc aagcatgagc agttcttttt 2605201 tcgggccttt tttcggctgg tgaacgtttg tttccagtag ctgctcgatc atagattgat 2605261 ctatgctgtc cggaactaaa atctccttcg gaaggaagtg gttgtttttt gaatagaact 2605321 gcccgatgaa cgtgaggaac tcttcatctg cttcctgata aagcgggaac atgctgacat 2605381 cgcgttcaat gagctttcct tggcggatga aaaagacctg cacgcacatc cagcccttat 2605441 cgtacgcgta cgcgaacaca tcacggtcga ctagatcgtt catcgtcatt ttttgttttt 2605501 ccatcgttga ttcaatatgg gcaatttggt cacgaagctc ttttgctcgt tcaaactcaa 2605561 gattctcagc agcttcatgc attttctctt caagctcttt tttgacctca ttatagccgc 2605621 cccttaagaa acgtgtaatg ctttcaacca gctctctgtt cgtctcttcg gaaatatcct 2605681 ttacacacgg agcaaggcat tggcccagat gatagtaaag gcacactctg tccgggagct 2605741 tggagcattt tctgagagga tacagacggt cgagcagttt ttttgtttcc cttgctgcct 2605801 gtacattcgg atacggcccg aaatagcgcc ctttgtcttt tttgacattg cgggtgacaa 2605861 tcagccttgg gtggcgttca tgggtgagtt ttatgaaagg ataggttttg tcgtctttga 2605921 gcatgacgtt gtatttcgga tcatgctttt tgatcagatt catttctaaa ataagcgctt 2605981 caagattgga ggacgtcaca atatattcaa aatcctcgat ttccgtcaca agcctttggg 2606041 ttttcgcgtc gtgagaaccg gtgaagtagg agcgcactct gtttttcagc acttttgctt 2606101 tccctacgta gatcacagtc tgctgccggt ccttcatgag ataacaaccc ggttgatcag 2606161 gaaggagggc gagtttttct ttcagttgtt tgttcatatg ttacccttcc ttatgtttaa 2606221 tcctttattt ccagtttaac acgaacgttt gtttttctct atggttcaca attggcgaat 2606281 aaaaaaagcg atccctcaat cggaatcgct ctggcatgta agcagcggaa aattaaagat 2606341 gtttgtttac aagctcttga agcgcttctt ttggtttgaa gccgactgaa gtttcaacta 2606401 cttcgccgtc ttttaacaca agaagagtcg ggatgctcat aacgccgtat tttccggcag 2606461 tttcttggtt ttcgtctaca tcgattttta cgattttcag tttgtctccc atttcttgat 2606521 ccaattcttc aagaacaggt gcaatcattt tacaaggtcc gcaccaagga gcccagaagt 2606581 ctgccagtac gacgccttcg cttgtttcag ctgagaaaga ttgatcagtt gcttttacga 2606641 tagccattat tgaattcctc caatgtgaaa tgatgatttt tagtatagca tctcccattc 2606701 gttcacgcta ttttaatgct tacaaattat tttttcctga tcacagccgg tttactcatt 2606761 tttatatggt tgaatgggat atgctctttt tttaaaacac aaatctgata atggccccga 2606821 tcactacaat tgccccaata atcattaaaa tggtacgaag cataagatca catctcctct 2606881 tcactgtcat gtactttacc atgccctgcc ggagctgttt taaaacctga aaaagagcgc 2606941 cggcatgaag ctccggcgct cttgcgcgat taagaatcag cacgcagcgt aagtaagacg 2607001 actgacattg gcgggagttt tactttcagt ttgtttttgc tgagcgtgta ttgtctgaag 2607061 gattccggtt tgacatgatg aggatcgtca aacgtgttat gcgcattcat tttttctgcc 2607121 gtaagaatga ctccggaatg gtccgctgcc ttgtgtaggc ccctcagctc gatttccgcc 2607181 tctgctttgt tttggtgatc gatgttgcaa attgtgatat tgatatcgcc ttcagcttgt 2607241 ttcgacgctg aaatgctgat ttgcggaagc gtttcaccgt tccattcata gtcggcagac 2607301 attgtctctg tggctaaaag agaagcgtcc tggtgcacct taaacatatt gaatacatgg 2607361 tacgtcggtg tcaaaagcat ccgctctccc tcagtcaaaa tcatcgcttg aagaacattt 2607421 actgtttggg cgatgttggc catttgcacc cggcggcaat gctgatggaa aatgtggaaa 2607481 tgagaagccg ccaccagtgc atcacgaatg gtgttttgct gatataagaa accgggattc 2607541 gtgcctggct cgggatcaaa ccacgtgccc cattcatcaa taatcagccc gacccgctgc 2607601 tccggatcgt accggtccat aatcgtgccg tgtttttgaa tcaattcatc gatgtatttg 2607661 gcttttttca tcgtaataaa ccattcatct tccgtgaatt ctgtggctga tcctttgccc 2607721 ttccagaaat cccccggaat cgtgtaataa tgaagactca acccgtccat caggccagcg 2607781 gcttttttca taagcacgtc cgtccaatta aaatcatcca catttgcgcc gcctgcaatt 2607841 ttataaatgt cattcccgct gtaattgcgg acataagtct gaaaacgccg gtacagatct 2607901 gcgtagtatt cgggatgcat gttgccgccg cagccccagt tttcattgcc cacgccgaaa 2607961 tatttcagct tccaaggctc ttctcttcca ttttgctttc tccagtctga catcggcgtg 2608021 ccttcttcaa atgtcatata ctcaatccac tccgacattt cctgaacggt tccgcttccg 2608081 acattgccgc aaatatatgg ctcgcattca agcagctcgc aaagcatcat aaattcatgc 2608141 gttccgaatt catttgattc aattgtaccg ccccagtgag tgttcagcat tgtcttacgg 2608201 tcaccgacac cgtttgccca atggtattcg tccgcaaaac acccgcccgg ccacctaagg 2608261 acaggaatgt gcagctgttt gagcgcctcc agcacgtcct ttcgtatccc gttgatattg 2608321 gggatgtctg agtccgttcc gacccagatc ccctcataaa tccctcttcc taaatgctca 2608381 gcaaaatgac cgtatatatt tttgttaatg gttccttttg cgatatctgt ttgaatcact 2608441 gcttgatgtt cagacatgcc tctgatcatt cctttcatac ggatatgaaa agcaccacag 2608501 tcaaatatgt gatctgtcgt ttgcctgagg agtcagcatg aatgtaagcg cttttaaagt 2608561 aaccatatta tatatgttcg tacatgtcaa cgacattttc tattgttttt atatttgtac 2608621 gtatgtattt ataaatatga aaaaacccgg acttttaaag tccgggattt cctttatgag 2608681 tgtatattca gctgtttgaa ttcctcagtt aataacggga caacttcaaa taaatcaccg 2608741 acgatgccgt aatccgctat tttaaagata tcggcttcgg ggtctttatt gatggcgacg 2608801 atcaccttgc tgtttgacat gccggccaaa tgctggatgg cgccggaaat gccgcatgca 2608861 atgtacaaat ccggagtaac gactttcccg gtctgcccga tttggagagc ataatcgcaa 2608921 taatcagcgt cacatgcccc gcgagaagcc ccgactgcgg cccctagcac ctctgcaagc 2608981 tcctgcagcg gctgaaatcc ttccttgctt ttgactcctc ggccgcccgc aacgataatt 2609041 ttcgcttcgg agagatcaac accgtccgcc gtttttttca cgacctcttg gataacagtg 2609101 cggaggtcag taagagaaac atcaatgctt tcgatgctcc ccgatctgct ggtgtctttt 2609161 tctgaagctt gaatgttatt ggggcgaatt gttgcaaaga tcatcggatc ggttgaaatg 2609221 acgcgttcaa aagctttccc cgagtaaatc ggccgtgtga acacaacatt ccctccggta 2609281 acgcttacat ctatagcatc agaaattaag cctgtttgca gacgggcagc aagcttcggt 2609341 gaaagatcct tgcccattgc cgtatgcccg aagatgactg aatcaggatt ttcttgctcg 2609401 ataacacctc tcatgacctg gctgtacccg tctgccgtgt atgttttcag cttcgggtcc 2609461 tcagcggtaa gaactttatc tgctccgtaa tgaataagct cttgtgcaat gctttgtaca 2609521 ttttcaccga tgagaacacc gatgacttcc ccatctcctg aaatggttct tcctgcagct 2609581 attgcttcaa aggtgacatt tcgcaattcc ccatcgcgta tttctccaag cacgatcact 2609641 ttttttccca ttctaacatc cccctgtttc tttgaatgtc caagttttaa atgactttag 2609701 cttcgctgcg gagcaatgaa acaagctctt ttgcctgttc agcaggctca ccttggagaa 2609761 gcttcccggc ttcttttttc ggcggcagaa aacgttcaat ggttttcagc tttggttcag 2609821 catcctcttc gtccagatca agatcatcaa gttcaagctc ttcaagcggc tttttcttag 2609881 ccttcataat tcccggaagc gatggatagc gcggctcgtt taagccctgc tgagctgtga 2609941 caagcaatgg gagcgtcgtt ttgatttttt caacatcccc ttcgacgtcc ctttctgctt 2610001 ctgcatcagt gccgttgatt tcgagtttgg tgatcgtagt gatacacgga atgtccagta 2610061 gctcggcaag ccgaggcgcc acttgtcctg atcctccgtc aatggcaaca tttccgccga 2610121 gaatcaaatc aaactcctga tccttcatat agtggtataa aacttgagaa atggaatatt 2610181 ggtcgggttc atcaagatca tcttctatgt tgattaaaac agcttggtca caacccatgg 2610241 caagcgccgt acgcaattct ttctccgctt cttcaccgcc gaccgtgaca gcggtgatcg 2610301 tgccgccatg cttttccttc agctggatgg cttcttctat cgcgtactca tcatatggat 2610361 taatgatcca ttccgctccg tcatcctgaa tctttcctgt ttcaatgacg attttttctt 2610421 ctgtgtcaaa cgtccgtttc atcagtacaa atagattcat gatcatatcc ccttttattc 2610481 gcctttgaac tgaggctttc ttttttcgag aaatgcctgg atgccttcct tggcgtcctc 2610541 tgactcaaat gcttccccaa atcgctttgc ttcaagcttt aagctgcctt cataggaata 2610601 caccttgttg gaataaagaa gttcaagcaa agatgccagc gtttgcgggc ttttctctgc 2610661 aaacttagcg gcaagtgctt ttgctttttc aatcacttct gcctcatctt tcgctccaat 2610721 tgagacaagt ccgagatcaa gcgcttcttt tccggatatc ggttctcctg atccgatgag 2610781 ctccagtgct ttggctgtac cgacatatct cggaaggcgc tgtgtccccg caaaacctgg 2610841 aatgataccg agattaagct ccgggagccc cagcttagca tcttctgccg cgattctgat 2610901 gtgacaggcc attgcaagct ccagcccgcc tccgagagca gcgccgtgaa tcgctgcgat 2610961 aatcggtttt ggaaaacttt cgattctctc cattaactgc tggccgcgct cagcgagcaa 2611021 tgaggaatcc tcattgcctt taagcgatgt aaattcttta atatcagcgc cggctgagaa 2611081 aaatcttccc tcgccgtgaa tgataatgct tcgtacgcct gcatctgtct cacattgatc 2611141 aagacaggaa gacagctctt ctaatatccg gcttgaaagc gcgtttgccg gcggattgtg 2611201 aatcgtcaag actgccacaa attgatcaac cgcaagtgaa attgcattca taggacagaa 2611261 ctcctttact tattgtgaat tccggatacc aataattcta aaacgctgtt tgaaagcgca 2611321 acgagatcgt acttttggtc attcatcacc caagttgtca cagtttcgtc aatcgttcca 2611381 aaaatcatct gccgggcgag gcggacatcg aggccttctt ttatttcgcc tgattgtata 2611441 ccttccgtca aaatgccatc caaaatattt aagtagcctt ttaatatttc gttgattttt 2611501 tggcgcagct ccaagttgga ttggcggagc tcaagctgcg tgacaatggc gagattatgg 2611561 tcacccgcta aaagggaaaa atgctttgaa atcacaagcg ccaatttctc tttcgctgtt 2611621 gctttttctt taatgtcctc ttccatccgc tcaataaatt gacccatttt ttctttgaaa 2611681 agagaaatta aaatatcttc tttgttttta aaatagagat agatggtgcc gtccgctacc 2611741 ccggcttgtt tggcaatttt ggatacctgt gactggtggt agccgttttc tgcaatgact 2611801 tctactgctg catcaataat ctgcatatac tttggccgtt tttgcttcaa tgttcatcgt 2611861 tccttcctat agaaatgaat gactattcat tcataatttc atgataagaa ggattttcag 2611921 gtttgtcaag tttattcata ggcgttctct ttttttattt gatatgatga ttttcggttt 2611981 cttcttcaag taaacgcctt cttaaaattt ttcccaccgc cgttttcggc agctcctttc 2612041 tgaactcata ggctttgggc accttatagg gagctagacg tgatctcgca aaagcgtcca 2612101 gttcttctgt atcggctttt gcgcctttct ttaatacgac aaatgctttt actgtttctc 2612161 ccctgtagga atcgggaacg cctgcgacaa caatttcctg gatggcttca tgttcataaa 2612221 gcgcttcttc tacctcacgc gggtaaatat tgtaaccgcc ggcaatgatg atatccttct 2612281 tcctgtcagc aatatagaaa aagccttctt catccatata gcccatgtcc ccggtgaaca 2612341 gccagccatc tctcagcact gcggcggttt cctctggttt attccagtat cctttcatga 2612401 cttgcggacc ttttacaatg atttctccat gctcatacgg agcggcaagc tcacccgtct 2612461 cttcagaata gatcgcagcg tccgtactcg gccaaggaca gccgatactg cccggcttgt 2612521 tttttcccca gataaagttg gcgtgcgtca ctggggatgc ctcagacaaa ccatagcctt 2612581 ccacaagctt tccaccagtc accttttcaa atttctgctt tacctccacg gggagcgcgg 2612641 ctgatccgct aagacagctt ttaatggatg acagatcata atgctgcaat tcagggtgat 2612701 gcaaaaggcc aatgtaaatt gtcggtgcgc caggaaagag cgtcggtttg tgtttgtcga 2612761 tgattttaag tgtttcgagc ggatcaaact taggaagaag aatcatttcg aagcctagtt 2612821 taatcgaata gttcatgact gccgtcagtc cgtagacatg aaaaaatgga acgatgccca 2612881 gcactttttc agcgccttct ttcacgtcat acatccaagc ggcgcacatt tcagtatttg 2612941 ccaaaatatt ttggtgcgtg agcatgaccc cttttggagc tccggttgtt cctccggtat 2613001 actggaggac agcgatatca tgctcaggat cgatcttcgg gattgtcagg agttcagttt 2613061 tttcctgctt catacaggaa gcgaacgtgt gaatgttagc tgttttgtca aagtcgatat 2613121 gcactttttg tttttgcgtc agcgggtaaa gaatattttt cggaaaaggc aaatagtctt 2613181 ttacactggt tatcaaaatc tggtcgacta ttgataacgt tttcattttt attgccttcg 2613241 ggaaaagcaa atctaaggtg atgattacac ttacctgagc atctctaagc tggtattcaa 2613301 gctcatgctc ggtataaagc ggattcgtct gcaccacgat gccaccggca aacaagacgc 2613361 cataataaga aatcactgtt tgcgggcaat tgggcagcat aacagccact ctgtctcctt 2613421 tttgcaggcc attgcactgc aaaaaagctg caagtttaag agcatccgtc agaatgtcat 2613481 gaaaggtgag tttttttcca taaaacgata ttgcggtttt atcagggaat cgtgcggcgg 2613541 agtctgtcag gatggattgc agggttttat tcggcaacgg aagctcatgc gggatatcgt 2613601 tgggatactc ggcaagccac ggcttttgag actgcataaa acctcccctt tcgattttag 2613661 agatccacct tatcattata gcagatggac ggcaaaaaaa agaaaaagaa aggtaaatct 2613721 ttctttttct cataatatga acagatatat aagaccaatt aacaaaaaga ttcccgctgc 2613781 ggcgagcagt attttcgcaa gcttttccat ctattctccg tccccttata ttccggctgc 2613841 caccacaaaa gaaagcccga cagaaatgac aaatgaaata aagccgacag cccggttatc 2613901 attttcgatt tcctgatcaa ttttaaaccg cggagtcaaa aactcaaaaa taaagtagct 2613961 gatcagaagc ataacaaacc cgtaaacgcc ccagccgatc atttgcagca gcgaattatg 2614021 ctgggagatg gaatgctgaa atacgtttgc gattcccaaa atttttccgc cggtcgccat 2614081 tgccaccgca agatttcctt tttgaatctc ttcccagttt ttataagccg tcaccagctc 2614141 aaacacagtc aaaaagagga cgaggcagag aaccgcgaca ctgtaatatg ccgcgatttc 2614201 cacaagctcg ttttcccaaa aatcactcat ggccatactc ccttttattt tagttcaaca 2614261 accgtaacgc ctgatcctcc ctcacctgct tcaccgaaac gggaactttt gacgctgcgg 2614321 tggtttttca gaagatcctg tacgcctttt cttaaagcgc cggttccttt tccgtggatg 2614381 attgacactc ttggatatcc ggctaacacc gcatcatcca agtatttttc aacccggctg 2614441 agggcatttt catagcgttc gccgcgaaga tcaagttcaa gcgatacgtg atagtccttt 2614501 cctttgaccg ctgtaatcat tttttctttt tttggctccg gagctgattt gataaactcc 2614561 agatcttttt cttttacttt catctttaaa ataccgattt gaacgttcca ttcattgccg 2614621 cctgtttttt cgagcaatgt tcctttttgc ccgaaagtga ggactttcac ctcgtcgcca 2614681 ggcttaaagt cgcgtttttg cgttttcggc ttttccggtt tcttggactt ttcaaaagca 2614741 ggcatagcgc cttctaaccg tttcttcgcg ttaatcagct cgtgatcctt gaaggatttg 2614801 tgttcttctt ttatggtgcg caattcatga ataatgtcct cggcttcttt cattgccgct 2614861 tttacttttt cagcagcctg ctgttctgcc tcttcaagca ttttgtcttt tttgctgtta 2614921 agctcgatga tttgctgctg cagctcttta tgcagttttt ccgcttcttt tctgattgat 2614981 tctgtctcag aaagctcttc ttccgcacgt tttttgcttt gttccagcga cgcaatcatc 2615041 gtatcgactt cgttatgctc ggccgtcatt tctgacttcg cctgcccgat gatatggtcc 2615101 gggagcccga ggcgttttga aatttcgaaa gcattgcttc gacccggcac accaattaaa 2615161 agtttatagg tcggtgacag cgtttcgatg tcaaattcaa cgctggcatt catgacgcct 2615221 tctctgttat agccgtacgc cttcaattcc ggataatgcg tcgtagctaa cactcgtgca 2615281 ttggtgcgat gcacgtcatc caagatgctc atggcgaggg ccgccccctc ctgcggatct 2615341 gtccctgcac caagttcatc gaaaagcaca aggctgtttt cattgacctg ttctaaaatg 2615401 ccgacaatat tcaccatatg ggatgagaac gtacttaaac tttgctcaat cgactgttca 2615461 tcaccgatat cagcgaatac gtgctcaaat actgccgctt ctgacccttc atctgccggg 2615521 atatgaagac ctgactgcgc cattaaggtt agcaggccta acgttttaag ggtgactgtt 2615581 ttccccccgg tgtttggccc tgtgatgaca atggttgaaa aatcgcggcc aagctcgatg 2615641 tcattggcaa caacctgatc aggcggaagc aatggatggc gggctttttt caaacggata 2615701 aagccggtgt cgttcataat cggttttgtc gctttaaccg cttttgcata tctagctttt 2615761 gcaaaaataa agtcaagcgt ctgcagcact tgcaaatcta gaaatagctc ctctgtatac 2615821 tctgccgttt tctctgtcag cacacgcaaa atccgttcaa tttcttgctt ttctttcact 2615881 ttcgcctgct gaagggaatt gttcatatct acaatcgcct gcggttcaat gaatagtgtc 2615941 gcaccagagg atgaggtgtc gtgcacaatt cctccatagc tggatctgta ctcctgtttg 2616001 accgggatca caaagcggtc attccgaatc gtaacaatcg tatcagacag cattttcgat 2616061 gcggaagagg aacgcagcat cgactctaac cggtctctga ctcttgattc gagtgttctg 2616121 agctgtgtgc ggattcctct taatgtttcc gatgcatgat caagcacttc tccgtgatca 2616181 tcaatgcagg aattaatgtc ccgctctaaa tcggacagcg tgataagctg ttcagcatgc 2616241 tgatggatca gcggaatgtc gacaccgtct tcagccattt gcgtgataaa atgtttcatt 2616301 tgtttaactg cataaagcag gcctgagatt tcagtgaatt cagaaggact gagaacgctg 2616361 ccgatttccg cccgtcttaa cgctcctctg atatctacaa ggccgccaaa tggcgcttgg 2616421 cctctcagcc ggataatgtc agaagcttcg tctacttcat ccagctgttt tttgatttcg 2616481 tctatagaag cagaaggctt aagctcgaga agcatttctt ttccgagcga tgaagcggca 2616541 tgcccaataa cctgttcttt cactttatga aattcaagag ctgataatac tttttgctgc 2616601 acgattgtgt gagcctcctt acttaatcgt tgcgcttcag aaatgcctct acgtctttaa 2616661 gcgaccgggc attcagaacg tttttcgttt ccgtccatcc tttgcgcgcg gcagtaacgc 2616721 cagttttcat atcgtctaac atctcaatat tatgggcatc agtattaatc accaatgtaa 2616781 ccccttgttc gtttgctttc attaaatgct ctgtgcgcag atcaaggcgc gcagggttgg 2616841 cattgagttc aagcgccgta tttgttttcc tcgcaagctc aatcagctga tcaatatcga 2616901 tttcgtaacc ggcccgtctg ccgataaggc gcccggtcgg gtgtgcgata atgtcaacat 2616961 gcttgtttgt cagtgccgtc tcaagccgtt tcataatcac gtgttccggc tgattaaaac 2617021 tggaatgaat cgatgcaata acgatatcca tttccgcaag cacatcgtca tcataatcga 2617081 gcgtaccgtc aggcaggata tccatctcaa cgcctttcaa aatacggaag ttttcaaact 2617141 ctgcattcag cgcgtcaatt tcttttgcct gctgcttaag tctttctgca gtaagcccgt 2617201 tggcgacctt taaatattgt gagtgatcgg tgatcgccat gtattgatag ccttttttga 2617261 tgcaggcttc agccatctct ctgatcgaaa atgcgccatc gctccacgtt gagtgcatgt 2617321 ggagatcacc tttgatttgc ccgagctcta tcagttcaat gctgtcgctg taggtttcca 2617381 cttcctgtcc gctttcacga atttccggcg gaatcagcgg caggccgaag tgcgcataaa 2617441 attcacgttc actcggaaat gttttgatct ctccggtttc aactgtctca acgccgtatt 2617501 cactgatccg ctcgccgcgt tctttggcga tttggcgcat cttaatattg tgatcctttg 2617561 atcccgtaaa atgatggagt gttgtcggaa actgctcttc cgtcacaaga cggaaatcga 2617621 cgcttgtttc atattcaaag gaaaggatga cggacacctt cgtatctccg cttgcgatca 2617681 cgcttttgat gtttggcagc tcaagaagct gctctcttac ttcagccgga tgatctgtag 2617741 caatgatata atccagatcc ttcaccgttt cccgcgctct gcggagactt ccggcacgag 2617801 aaaatttgat gatatgcgta aattgagaaa gatgctcctc aatttcccgc gcgatccgga 2617861 gggcgtagcc gatcgggaac cgttcaggct gttttccggc ttccccgagc gcctgtaata 2617921 ttttttcttc cgattttttg ccgaagcccg caagaccctg gaccttttgc tgctcacagg 2617981 cttccttcag agattctgca tcgtgtacgc cgagctcttt atacagcttt gcgatttttt 2618041 tgccgccgag ccccggcagc ttcaataaag gcacgagtcc ttccggcact tctttctgaa 2618101 gcgattcgag cgtgcttgac tttccttcat ctatatactc tttaatgacg ctgtacgttc 2618161 cttttccaat gccggacagc gacatcatat cgtccatttc tgataagctt cggtcgtcct 2618221 gttccagagc tgccgccgct tttcggaagg cggatacttt aaacgggttg tcccctttga 2618281 gttccatata gactgcaatg gtttcaagca gccggataat atctttttta tgcatatcat 2618341 aacccccaga cgttcacata tgtttccatc atacttgaaa aaaacttctc cggacaagag 2618401 aagttttttt atgccccgta ctgtgtccac agctcttgta aaagccctga caagtacggt 2618461 gtatggttaa tgatcacatt tgcgagagac gattgcccca tcatttgctg caacgcgtct 2618521 accggcagaa cggatgcgac atacagcagc acaaatgtaa ataaatagac ttctagaaaa 2618581 ccgagaacgg ctcccagcat ctggttgatt tgtttaatca ccggaatgcc ggctacaata 2618641 ctcaggaacg agccgatgat tctcagtaag attttagcaa tgataaataa aacgataaac 2618701 gcaatcgcat tatagtacgc tgcttccaaa ttccccgtaa aaaaagaaag agccggctgt 2618761 cccgctgaaa aatcgggtgc gggaatccaa tgtaaatgcg gtgccacgtt tttatagaat 2618821 aaagccgcaa aggcaattga taaaataaag ctcgtcaagc ggataaactg caggataaaa 2618881 ccgcgtttta accccagtaa agtccccatc aggagcaaga ttaagatgat gatatctagc 2618941 atagttgttc aatccttttc tttaagctga cgctccagtt tttcacattt ctcttgtaat 2619001 ttgacataat cgtgcaccac atttaccgct gtcagcactg caagtttatt tatatcaagg 2619061 tatggatttt tttcattgat ttctctcatt ttatcatcaa caattccggc gacatacctc 2619121 atatgggctc tgctttcttc accgacaatc gtgaagtgct ggccgtaaat gtcaacggtt 2619181 gtttttgttt ttttgccgtc agacaacgtt tctcctccat tccgcgagaa tcctagttct 2619241 tatcataaca cgtttattaa atgaatggaa agacgagcct cccgctgtta tgatacactg 2619301 gtatatacag cgaaaagtgt aaaaaaagga gattattacg tgtcccattc agtgataaaa 2619361 gtatcgttgt ctgctattga ccaaatgaaa atgacgtaca gcggttcact tacagcctct 2619421 gttccgcagg gagccgtttt tcaggcaaaa ccgcccggct gtaccattac agcatatcaa 2619481 tcaggtaagg tcttgtttca aggaaaaaac gctgcggcag aatccgcgcg ctggggaaca 2619541 gcagagcctc aggaaaagaa gaaaacggcc aaaaagccgg ctgatccccg ctatgcccct 2619601 ccggcagata tcgccggaat gtctgttatc ggttctgacg aagtcggaac cggagattac 2619661 tttggcccaa tgacggttgt atgcgcgtac gtcgacaaaa ccatgcttcc tttaatgaag 2619721 gaactcggtg ttaaggattc taaagattta aaagatccgc aaatcatcga gattgcccga 2619781 aacctgatta aaaccattcc gtacagcctg ctggtgttaa agaatgaaaa gtataacagc 2619841 atgcaggaaa aaggcatgag ccaagggaaa atgaaagctt tgctgcacaa tcaggcgatc 2619901 acacatttat taagaaaatt ggatggagta aagcctgaag ccattttgat tgaccaattc 2619961 gctgagccag gcgtctactt caatcattta aagggcagag acattgtgaa ggagcggacc 2620021 tattttagca caaaagctga aggtattcac ctggctgtcg ccgctgcttc aatcattgca 2620081 agatattcat ttttaatgga aatggataaa ctatcacgcg cggcaggaat gacgcttcca 2620141 aaaggggccg gtccgcacgt cgatgaagcg gccgccaagc tgatcctcaa aaaaggggca 2620201 tctgcactca gaacctttac aaaactccat ttcgccaata cgcaaaaagc gcagcgcctt 2620261 gctgataaaa aacgttcata gaaaaaagct tgcagatttc tctgcaagct tttttatcag 2620321 cctcttaaaa cagcttgata tgtgtcttct aacgctttca gcactttgct gtgcgccttt 2620381 gtcacttctt cttcagtcag tgtttgttca ggattgacat actggagtga gaaagcgact 2620441 gacttcttgc cttcctccat atgctctcct tcgtatacgt caaatacggt tacctctttc 2620501 agaagcttgc ccccggcctc tttaatgacg ctctcgagct gtccgcttgt gacggtttta 2620561 tctgttacaa gagcgatatc acgtgtcaca gacggatatt ttggaatcgc cgtgtaaaca 2620621 agcggtgctg tttctgctgc gagcaacgca tgaagatcga gctcaaatac gtatgtttcc 2620681 tttatatcca gttctttttc caatgaagga tggacttggc cgatgaagcc gatcagagaa 2620741 ccattcaata aaatgttcgc tgttctgccc ggatgcagct gtttgcgttc agactgtaca 2620801 aattcaatgc tgtctaggac gttgagtttg tctaacagcc cttccacaat tcctttgaca 2620861 acaaagaaat caactggttt cttttcaccc tgccatagct gcttgcgcca taatccggta 2620921 acagctcctg ctacgcgttc tgtttcaaca ggttttgtgt cctcttcctt cgttaggaaa 2620981 acggagccaa cttcgtacag tgcaactgag tcagtctgcc tcgcaagatt gtaagaaaca 2621041 gaatcaagca gatttggaac aagactgtgt ctgagaatgc ttctttcttc actcattgga 2621101 agcgcaagca cagtattcag tgatttttca atcgcaaacg ctgtcgcttt cttctcgttt 2621161 gtcagtgagt aagtgatggc ttgtgataag cctgcgcctt caaggaagcg tctgacttta 2621221 cggcgttttg cctgatatgg cgttaatccg cctgtagttc ccgctgtctc aggaagcgta 2621281 gacggaatgt tatcgtagcc gtacagtctt gccgcttctt cgattaaatc ctcttctatt 2621341 gtaatgtcac cgcgccgtga tgggacagtc acaacgagaa gatcatccgc ttcaccgacc 2621401 gtaaaaccga gacgtttata aatgctgatc agttcttctt tactgatcgt caggcctaga 2621461 acgctgctca ctttgtcagc agatacgtga atgttatttg cttcgattgt caggtgatct 2621521 tcctcaaccg ttccagcaag cacctcaccg ccggcataca gatggatcag ctgcgcagcc 2621581 cgttctgctg caagacgtac gcgtgccgga tcaattcctt tttcaaatct tacgcttgat 2621641 tcacttctca aaccaaggtc tttggaagcc ttgcgaacct tctgcccgtt gaaatacgca 2621701 gcctcaagca aaatggtttt cgtatcttcc tgaacctctg actctgctcc tcccatgaca 2621761 ccggcaacgg cctgcgcttt cgttccgttt gtaatgacaa ggtgatcggc agacagctta 2621821 cgttcttgat catcaagtgt tacgatcatt tcattctcag ctgcttttct tactacgact 2621881 tccttagagc caaatctgtc ataatcaaac gcatgaagcg gctgtccgta ttccaacagg 2621941 acaaaatttg tgatgtcaac gacgttgttg tgcggacgaa tgcctgcatt catcagcttt 2622001 gtctgcatcc aaagcggtga cggagcaatc gtgacatttt taatgatttt tgcagtgtac 2622061 agcgggttcg cttcttgatc ttcaattttg actgaaatgt aatcagacgc ttgttctgaa 2622121 gcagccgggt aatccgtttg cggaagcttt acctcagtgt ctaaaatcgc cgcaacctcg 2622181 taagcaacac caagcatgtt catggcatcc gcgcggtttg gcgttaaacc cagctcaaga 2622241 atcgcatcgt caagctgtaa agccgctaag gcatcgcttc ctgtttcagc gtcattcggg 2622301 aatacgaaaa tgccttctgc atactccttc gccacaagtt tgctttcgat accaagctcc 2622361 tgtaaggaac agatcatgcc gtttgattct tcaccgcgaa gcttggcttt tttgattttg 2622421 aaattgcccg gcagcaccgc tccgactgtt gcaactgcga ctttttgtcc cttatccaca 2622481 ttcggcgcgc cgcaaatgat ttgtacaggg gcttcagctc cgatatccac aaggcactta 2622541 ttcagcttat cagcattcgg gtgctgctcg cgctccagca catggccgat gacaacgcct 2622601 ttgatgcctt ctcctttgta ttcaattcct tcaacctcaa taccggctct tgtaattttt 2622661 tcagcaagaa cagccgggtc catgcctttt aaatcaacat aatcctctaa ccatttataa 2622721 gaaacaaaca tccttgcatc ctcctcttac gcctgtttaa actgcgaaat aaatctgaca 2622781 tcgtttgtat agaagtggcg gatatcatca atgccatatt tcagcatcgc gatgcgctca 2622841 acacccattc cgaatgcgaa gccctgatat tccttcggat caaagccagc cattttaagc 2622901 acgttcgggt gaaccattcc ggcaccgagg atttcaatcc agcctgttcc tttacatact 2622961 gagcagccgt tcccaccgca tttaaagcat gtcacatcca cttctactga aggctcagta 2623021 aacgggaaga agcttgggcg gagtctgatt tcacggtctt gcccgaacat ttttttcgca 2623081 acaagttcaa gcgttccttt taaatcactc atgctgatgt ttttgtcaac gacaagccct 2623141 tcaatttgca taaattggtg agagtgcgtc gcatcatcgt tatcacggcg atatacttta 2623201 cccgggcaaa tgattttaac gggacctttg ccttcatgct tttccatcgt acgtgtttgg 2623261 acaggagaag tttgcgttct catcaaagtt tcctctgtga tgtaaaagct gtcctgcata 2623321 tcgcgcgctg ggtgttcttt cggaagattg agcgattcga agttgtagta atccgtttca 2623381 acctctggcc cttcctcgac tgtgtagccc ataccgataa ataaatcttc aatttcttca 2623441 atgacaacag tgagcggatg gcggccgccg actgcaacag ggttccccgg cagcgtgacg 2623501 tcaattgtct gtcctgcaag cttctgtttc atttcctctt cttcaagctt ctcgtttttg 2623561 tcagcaatcg cattggcaat acgctccctt acttcgttcg cgagcgcccc catttttgga 2623621 cgttcctcag cagaaagctt gcccattccg cgcagcactt ctgtaatcgg cccttttttt 2623681 ccgagatatt gcacccgaat atcattgaca accttcaatg agcttgccgc ttctacttgt 2623741 tctaaagctt cttgttccag ctgttttagc ttttcttcca ttttgcatcc tccttttatg 2623801 taaacaaacc gtcatatgtc tttggaaaat aaaaaaaacc cgtcccttgt acaagggacg 2623861 agttgtggcc gcggtaccac ccttatttca gacagactga tgctgtcgtc agcttcattg 2623921 acataacgga atcagattcc ggttcacctt tacgcgcagt gtacgcggtc ccggcgacaa 2623981 ctcaagaggt gaagccaatt tccggctgcg ttaaaaatgc tctcagtcag cggcattttc 2624041 tccctggaaa gcagttgatc agaaattgag gtcctctgtc acggtttttg aaatattatg 2624101 ttctattata gagaaatcca acgcttggcg caacactatc ctcgcaagtg atacacgagg 2624161 atggcagccg caaccgcaac gtttagtgat tcagcctgtc cgtaaagcgg cacgtacagg 2624221 ttcaaatccg ttttttccag caatgcagca tctacccctg caccttcatt tcctacaatg 2624281 agcgcaaagg attcagactg aggaatctcc tggtaaggcg ctccgttttg cagcgccgtg 2624341 ccgtatactt ttacgccctc tgccttcaat tcgtccacat atgaaggcag gtttcttctc 2624401 acaacaggaa tatggaagtg agatccttga gcagatcgca gtgtttttcc gttaaaggcg 2624461 tccgccgtgc cgtcaccgag tacaaccgca tccaaaccgg ccgcatcagc cgttcgaatc 2624521 attgtgccaa ggtttcccgg atcttgaaca gcgtcaatca gcagcacctt gcgtgccgtt 2624581 gccagctttt cttcaggcat atggcacaca gcggcaatct gctgcggcgt ttcggtttca 2624641 gtcacagctg aaaacgcatc ttcactcagc atatagcact ggataccagt ctcaagatct 2624701 gaaggaatcc tcgtttcatc ctttacaagg atttctttca caatgcccgg gcttttcaac 2624761 gcctcttcaa cgaggtgttc tccctctatc agaaatgtat ttgtttttgt tcgttctttt 2624821 tttgtgtgaa gctttttcca atccttcact ttttggtttt ttgccgattc tatttgtttc 2624881 actgtctatg tggcgctcct ttttttaaca tgatgttatt atatcgcaag aacagcacat 2624941 aataaaccag gtgcagggtt agaatatacg tattacattt tagaaaaagg agcgttttac 2625001 atggatctta atttacgtca tgccgtcatt gccaatgtca ccggcaataa tcaggagcag 2625061 cttgagcata caatcgtaga tgcgattcaa agcggtgaag aaaaaatgct tccagggctc 2625121 ggcgttttat tcgaagtcat ttggcagcac gcatccgaaa gtgagaaaaa cgaaatgctg 2625181 aaaacgcttg aaggcggatt aaaacccgcc gaataagaca tgaaaccggg tgacagcgcc 2625241 cggttttttt cttatataat aaaaacatga tgagggggaa cgccatgttt ttacagccgt 2625301 tattagcgaa aaaaattatt gctgaagtta aaaaaatgta cgaacgtgaa gtcattattg 2625361 taaacacgga cggtcttatt atggcaggca caaacgatga gcgtgtcgga caatttcatg 2625421 agggagcgct tatctgcgca aaagaaagac gcagcgtgat tattacaaaa gaagatgaaa 2625481 caaggttaaa aggagtgaaa gcaggcataa acctccctgt attttttgac catgatgtga 2625541 ttgccgtctt cgggctgaca ggtgagcctg cagagattca gccattcgga gaactgcttc 2625601 gaaaaatgac agaactgttc attaaggaat cgcggcactt agagcaatcc cagtggcgtg 2625661 agagaatgct ggagtccttt atgatcgatt ggctgcaatt aaaggagtgg tctcccagtt 2625721 ttcttgagaa agctcagctt cttggtgttg acctttcttc ccggcgccaa atgattctta 2625781 ttcaggggta tgagtggtca cctcatgata ttgaacaaat ggcacgcagc tggaaatcct 2625841 cgtaccctgc ggatttgttc atcaggtggg gaaatgaacg gattttgatt aatcatgaag 2625901 tgccgcagca tgaacaaagg gatcggcttt tgcggaaaat ccttcacatt tgttcgtttg 2625961 ccaataccgc aagcagccaa tatacagcag ctggcgccgg aagggctgtc gcaagctcca 2626021 gcctgacaga ttcatacgag caagcggaaa aagcgctggc tgtcagcctt aagcgaaaaa 2626081 cgcccatatt tgaagaggat ctgaagcttg atatgtgtct gacggagatc agcccgggaa 2626141 cccgaaacga atttccgcaa agagtattag gaaaggcgct agagcatcag gaacttatga 2626201 atacgatacg gactttcttt catcacgatt tgtctttgaa acaaaccgct gaagacatgc 2626261 atatacacat caatacattg cgttatcgtc tggctaaggc tgaacagctg acgggattac 2626321 gttttgaccg taccgaggac gtcgtcacga tgtacgtcgc actctatttt ttagatcaag 2626381 atacaaaata gagagagttt cagtttcatt ttttgtatgt ttctccatgg aaggctttgc 2626441 tttttttctt ttacaataga ttgaaagcgt tttttgacag ggggatgggt gaaatgatca 2626501 ccaaggatgt aaaggagcag ctgattcagg tctccggacc agaaaacttt gatgactcga 2626561 atgccggccg tctcgtctat tcatatgatg cgacgcctca gtatcagtct atgcctgatg 2626621 ccgtgattgc tccgaggaat actgatgaaa tatcacgcat tttaacaatt tgcagcgaac 2626681 atcgagtgcc gatcgttcca agaggatcag ggacaaacct gtgcggcggc acgtgcccga 2626741 ctgaaggcgg acttgtgctt ctctttaagc acatgaacca gattcttgaa attgatgaag 2626801 aaaatttaac tgccacagtt cagccgggcg tcattacgtt ggatatgatc cgggcagttg 2626861 aaagcaaagg tttattttat ccgcctgacc cgagttctat gaaaatatca actatcgggg 2626921 gcaacatcaa tgaaaattcc ggcgggctac gcggattaaa atacggtgtc acccgcgact 2626981 atgttattgg actggaggtt gttctcgcaa atggtgacat catccgcacc ggcggaaaac 2627041 tcgcaaagga tgtggccgga tacgatctca cacgtctttt tgtcggctca gaaggaacac 2627101 tcggcattgt gacagaggca atcgtcaaac tcgttccaaa gccggaaaca aagaagacgc 2627161 tgcttgccct ttatgaaaac atcgatgccg ctgctcaaac ggtatcggac attattgccg 2627221 caaaaattat acccgctacg cttgaatttc tcgatcagcc tacactattg gtgattgagg 2627281 attatgccaa aatcggactt ccgacaagcg caaaagcagt tctgttaatt gaacaagacg 2627341 ggccatttga aactgttgaa cgggatatgg aaaagattga ggcgatctgc aaaaaaggcg 2627401 acgccgtatc cgttcagacc gcacaaacag aggaggaagc gtttgccctg actgaagccc 2627461 ggcgttctgc actttctgcc ctagcccgcc tcaaaccgac gacgatttta gaggatgcga 2627521 ccgttcctcg ctcagaaatc gccaatatgg ttaaagcgat taatgatatt gctgctaaat 2627581 atgatatttc catctgcacc tttggtcatg cgggagacgg gaaccttcac ccgacatgca 2627641 cgacagacat aagaaataag gatgaaatgg aacgtgtcga acaggctttt gccgagattt 2627701 ttgagaaagc gattgaactt ggcgggacga taaccggaga gcacggagtc ggggaaatga 2627761 aagcgcctta cttggaaatg aagctgaaaa aagaaggcat tgatgcgatg aaagcgttga 2627821 aagcggcatt tgacccccgg aacatattaa atcccggcaa aatgtttgcg aaagatgcca 2627881 gaaaacgtgt ggtggcggaa agatgacaac agaaaaagaa atgaaacaga tccaaaatga 2627941 atttaaagag cgtatggatg aaggagagtt attaaattgt atgcgctgcg gcttctgtct 2628001 tccttcctgt ccgacctata tcgaatcggg atttcaggaa acacactctc cgcgtgggcg 2628061 catcgcctta atgaaagccg tagccgacgg tatgattgaa ccggatgaag atgtcgaacg 2628121 gtcgctgtca ctttgcctcg gctgccgcgc ctgtgagcct gtatgcccgt ctggcgtgaa 2628181 atacgggcag ctgcttgagg aagccagaga tattatccac caaaataaaa aacactctct 2628241 tggtgaacgt gtcatgcgaa agacggcttt tcacgagctg tttccgcatc aaaaccgcat 2628301 gcgctcagct gtaagcctta tcggtttgta tcagcgttca ggactgcaaa ccgctgtgcg 2628361 aaaatcaggc atgcttcggg tcctgcctga gcatttgcgg acgatggaag ctgttcttcc 2628421 tgatgttcca aaaagcaaag acatgaaaca tcggccgcgt ttcctgcctt ccattggccc 2628481 catgaaaaaa cgggtcgcct ttttttcggg ctgcttaatg gatacaatgt ttttaccgac 2628541 caataacgcc acattgaagc ttttacagct ggcaggctgc gacattgtca ttccgcctga 2628601 acaggcttgc tgcggggcgc ttcatggaca cagcggtgaa aaaaacacag ggaaagagct 2628661 cgcgaaacaa aatatcgctg ctttcgaagc attagacgtg gatgcagtca ttacaaacgc 2628721 aggaggatgc ggagcctttc tcactgaata tgatcatttg ctgaaggatg accctgagtg 2628781 gtcggaacgg gctgccgctt ttgttcaaaa gctgaaggat ttttcttctg ttttggttga 2628841 actcgatttc catcaaatgg atctagcact cgagacgcct caggtcgtta cctaccaaga 2628901 ttcatgtcat ctaagaaatg tgatgcatac gtcactcgag ccccgccagc ttcttaaaag 2628961 catcaaaggg gcggaattca aagaaatgga gaaagcagac agctgctgcg ggtcagcggg 2629021 aatttacaac atcgtcgaag ttgaaatgtc tatgaaaata ctggacagca aaatggctgc 2629081 cgtcaaagca accgaagcga tcctcattgt aacagcaaat cctggctgcc tgctgcagat 2629141 gaagctcggc attgaacgcg aaggactaag cggtaaagtc agagccgttc acctggctga 2629201 tttgctatta gaagcagccg ggcacaaaac atcatgagaa agcccaaaac agacattgtt 2629261 ttgggctttt gtgcgttatt ccatcggact gcaaatttcg atataatgtc catccggatc 2629321 agcgatatag gcgaccgtct gcccccatgg tttcactttc ggctccccga taatcgatac 2629381 gccttgttct ctcatccttt tgatgaccgc ttctacattt tcagtaacaa acccgatttc 2629441 aaatgtgttt gaagcagatg tatccggaat gtccagcgcc gtgatgtctc tggcgctttc 2629501 ccgggtatta agcgccaata tcgtagaccc tgtatcaaat tcgacatacg tgccgtgttc 2629561 agcacgaatc ggcagtccta aaatatcccg gtaaaaaatg aatagcccgc ttgctgtccg 2629621 atacgtatag aataagatat ttcattgata gattcattgc caacccctct cagcattttc 2629681 aatagtcctt ctagcccggt atagatgctt ccatccttaa gctcggatct ttccacatct 2629741 gcgcccattt tttcacagcc gccacgataa tgatgaagcc taacaccagc atgatgatag 2629801 ataatacgcc attcaataca ctatatcctg ctgcttcagg attgagatac acattgcgca 2629861 ccatccaata gcccgcataa ttgacagtga catataaata ggcaagcggg ataaggcaag 2629921 tcagaatgta ccggcgttta tcggcgattt tcagcacgat cgtcgctccg ataatcagcc 2629981 ccactgaagc catcagctga ttagaaacgc cgaagagcgc ccaaatggaa ccgatatctc 2630041 ctgaatacag caagtacccc cacatcaaac aggcaagcgc gctggcaaat acagagcccg 2630101 gaatccagtc tgttttcttc agcggcttat acacctcccc gaagaagtcc tggatcaaat 2630161 aacgggcgac acgtgtgccg gcgtcaatcg ctgttaaaat aaagaccgct tcaaacataa 2630221 tgacaaattg gaaaaagtat gaggccaaat ggctgaaaaa cggcattccg gtaaaaatat 2630281 aagtcatccc taccgcaagc gtgacggctc cccctgttct tccttctaag tccaaaccga 2630341 tttccccgct caattcaggc aaatgtacga cattcatgcc aagcgtacgg aaaacctcag 2630401 gcgtgctgtt aatcgcaaag taatcagcag gctgtaaagc ggtcgctgca atcagcgcca 2630461 tgataccgac aagacactca acaagcattg cgccaaacgc aaccggcttc atatcactcc 2630521 atttattcag cattttcggt gtcgttcctg agccgacaaa ggcatggaac ccagagatcg 2630581 ccccgcaggc gatggttatt gagatgaacg gccagacagg tcctgccagc accggccctc 2630641 cgccttttac gaattctgta aacgcaggga acggaatgga cggattgacg acaaacacac 2630701 caacaatcaa agcgataaaa acaccgattt tcataaagct gcttaaataa tcacgcggag 2630761 ccagaagcag ccaaacggga agcgcagccg caaaaaacgc ataaacagga agcgcgattg 2630821 caagcgtttt cgtatctagc gttaaaaagt caccgagcgc ggtagtctgt acccatggac 2630881 cgataaagac tcctgccatt aaaaagagaa agccgaccgt tgaagcgagc tttaaatttc 2630941 ccgttttctt ataaaataag cccacaccca tcgcaatcgg aatcgtaatc cccaccgcaa 2631001 atgttcccca tggattacgt tcaagcgcat gcaagacaac catcgacagg cccgccattg 2631061 tgatcgtgat gataaacagc atggacagtc ctgtacaaaa tcctgcaaca gggccaagct 2631121 catccttcgc cacttccgac agcgattttc cgtttttgcg catcgatgca aacaacacca 2631181 caatatcatg gacggctccc ccaattaccg ccccgattaa cagccacaat aatcccggca 2631241 aatagccaaa ctgcgccgcc agaattggtc cgaccagcgg cccggccgct gcgatcgcgg 2631301 caaagtggtg gccgaacgaa acccatttat ttgtaggcac atagtctttc ccatcctcaa 2631361 gcgcatgagc aggtgttggc ttgtcatcat tcactttgag aaccttcacc atcataaatg 2631421 ttccgtataa acgataggca atagccaaaa tacacattga tgctatcaca attgtaaccg 2631481 cattcatttt ctcccatccc cttttctgtt tttcataaat atatcataat ttcatggtga 2631541 aaagcggtca ttttttccta tacaaaaagc cggctggaat gggccggctc gtggcagttg 2631601 aaagacaagc cggagagaaa tctccggctt tgctattctt atgactgttt tttcaggcgg 2631661 atcacattcc aggaaagcgg cgtgaaatga gcagttaagc cgttttcgct gacagacgat 2631721 gatccgttgg aatgcggaac gacatttttt ctgttatgct ggtttgttgc tttgatatcc 2631781 tgatgctcaa gtacgatgtg ctctgcgatt tggtaggatt caaagcctct gagcgaaatc 2631841 tccgtctcca tctgatcctc agccttgttt accgcaaaaa tagtgagtgt ttcttcctct 2631901 tcagagtaca caacagcagc atcaacatat ggcacatcag tgaaatcaga acaatcgtac 2631961 ttaggagaag aaataagcgg tttcagtgac tcgccccttc cgtaaacaga agcatgcatg 2632021 tatggataga aaatcggctg tctccatgct tctccgcctt tttccgtcat gatcggcgcg 2632081 atgacattaa caagctgtgc aagacacgca attttcacac ggtctgcgtg ctgcagcatc 2632141 gtaatgagca gagagccgac taataaggca tcttcaaaat tgtaaatatc ctctaaaatc 2632201 ggacgcgcag tgatccacgg ctcgactttt ttatcagcct catttgagtg gtaccagacg 2632261 ttccattcat ccagagagag attgatagtt ttcttgctgc gtgtttttgc ttttacatag 2632321 tcacaggtcg cagcgactga tttgataaaa tgatccaaat ccatagaacg tgccaagtag 2632381 tttggcagat tgttatcccg gtttccgtag taagtgtgaa gagagatata gtcgacatgc 2632441 tcatacgtat gctcaagcac cttcgcttcc caatcgataa aggtcggcat accgctgttt 2632501 gagctgccgc aggcaacgag ttcaattgat gggtcaaccc acttcatgac ctttgctgtc 2632561 tctgcggcaa gccgtccgta ttcatcagct gttttgtggc cgatctgcca tggtccatcc 2632621 atttcgtttc ctaagcacca tgttttgatg ccatacggct gttcatagcc atgcgatctt 2632681 cttaaatcac tccagtaaga gcctttcgga tggttgcaat attcaacgag attacgggcg 2632741 gcatctatgc ctcttgtgcc aaggttgacg gccatattga cctcagtgtt cacctttttt 2632801 gcccaagata aaaattcatt tgttcccact tcattggttt ctgtcgtttg ccatgccaag 2632861 tcaagccgtc tcgggcggtt ttcgactggt ccgacaccgt cctcccagtt gtatccggat 2632921 aaaaagtttc cgcccggata gcggatgatg ggaacctgta attctttgat cagcgactgg 2632981 acatcttttc taaatccatc ttcatccgct tcagggtgat caggctcgta tatgccttca 2633041 tataccgcac gacccatatg ttcgataaac gagccataaa tccgtttatc tacttcaccg 2633101 attttatatt ctttgtctac aatcattcgc gcttttttca tcacacgttt cctccttcat 2633161 taacctttga ctccccctac cgtcaggccg gagataaagt acttttggaa aaacaagaaa 2633221 atgataatca ccggcaaaat cgcaaatact gagccggata taagcatgtc gtaattattt 2633281 ccataagggc tcagcaagct ggacagccct attggaagcg taaacatttc tttcgaccga 2633341 agcacaatca gcggccacaa gaagttgttc cagctgttta aggactgaag gataatcatc 2633401 gcaccgaaag ccggtttcat cagcggtgcc ataatcctga aaaagatgcc gaattccgta 2633461 cagccgtcca tccttgcaga gtccagcaga tctcttggaa ggccaagagc atattgcctg 2633521 aaaaagaaaa cagcaacagg tgaaacgata aacggcaata tgacacccgt atatgaatcg 2633581 atcaagtgca gtccgacagt aagtttaaac agaggaagca tcatcacttc cagcggaacc 2633641 atcataataa tcagcacaag aacaaagatg atatttctgc ccttaaaatc ataaaccgca 2633701 agcccgtacc cgatcatcga agaaaaaaac agagtgagca cagtcgtaaa aagtccgagt 2633761 acaagactgt taaaaaacca tttgaaataa atgctgccgc cattaaacag aaatgtgtag 2633821 ttatcaaaac tcatcacttt tggatcaata tcaagattca gccccacacg caaaagctca 2633881 gatgacggct ttaatgatcc taaaagcaaa cagaaaatcg gaaaaagata caataggctc 2633941 agcatcataa aaaacagggt cagcgcaatt ctataaacgc taaactgagg actgtgccgc 2634001 aacatttatc cctccccctt aaacgagcct gacagcttta atgaaatcag gctgacaaca 2634061 aggatcacaa tcaaaagcac aatgccgatg gccgctccgt atcccatttc attgtaggca 2634121 agtccctgct gatacaaata tccgacaagc gtcagaccaa tattacccgg ggaattattc 2634181 tgccaaagga cgtagctttc ctcaaacatc ctgaagccgc cgatgatgct gatggtcagc 2634241 acatatacgg ttacaggctt gagaaacggc agcgtgatgt gcagaaattt tttcattgta 2634301 ttcgcgccgt ctatatcagc ggcttcgtac agctctttcg gcacattttg caaacctgct 2634361 aaaaagtaaa ggatgttgat tcccatccat ctccatgaag caagcagcac catcaaaaac 2634421 atgccggtat gttcattgtt catccagttc tgaggtgaaa agccgagttt aagtaggatg 2634481 gaattggcca gagacgtttc catttctccg aagatcagcc gaaaaatgat ccccgcgaca 2634541 atggttgagg tcaatgccgg gataaataat gctgatttaa atatatttct aaatttgacc 2634601 agctttgaat tcaggaatat ggccagaagc aatggaacag gaatcagcac gatcagcgtc 2634661 caaaaggtgt attccagcgt attccaaagg gcggtataga acgtcgggtt gtttagcgct 2634721 gtataattag acaatccgac aaaggacacc tctcccggca aaattctttg gaagctcatg 2634781 atgaagacac taatgatggg gtatagaaaa aatacgagaa aggataaaac gaatggcgct 2634841 gtaaacagat agggcgccgc tttttttgaa taaaacagat ctcgccagcc tgattgtttc 2634901 gcagctgaag gaacgggatg aaccgttccc gttttcacag gtttcatgag aacctccccg 2634961 ctttcacttt ttgaatggga ttctatttct gtttcagttc acctgccgct ctgtccaagg 2635021 cttgtttagg cgttttttgc tgagatttaa gcgcgtcgaa caatacgctt ctgttgacaa 2635081 ggtctgaagc cttggcaaaa tcctcatgta aataaattgg attgatttca tccttgatat 2635141 cgagcagcac agaaaaaatg cctgttccgt tttggaagta atccgtgtat ttgtttttct 2635201 ctttcaattc cttggagctc caaacatccc agcgaagcgg gtcaaagccg agtacgctcc 2635261 agagtttttt atttccttct tcagagccct tcgcaaaggc caaaaactct tttgctaact 2635321 caacatgctt ggattgcttc ggtacaacag ttgccgtacc gcccaaacct gccgagcggt 2635381 cgcccccctc tttccatgcc gggagcggtc tgatggcaat cttccctttc agatcaggca 2635441 tataatcgat aaatcttccc atataccaaa tcggcatgag aactgaagca gctcctcctt 2635501 ggttcataaa gccgtagtat tcttcactgt gatgcccgcc gcccggcgca ggaatcatcg 2635561 ttttatcatt gatcatgtct tttaaatatt gaagtgtttt tacgttggtg tcattattga 2635621 ggatcagctt gccgttttta tcaaaatagc ctgagttttg ctgtgaaatc atagataaga 2635681 acgttgcgga atcatttgtt tccaccgttc ccatcggctt cccggtcact ttgcgcactt 2635741 tctgtccggc tttatggtaa tcatcccatg ttttaatatc gtcaggattg acgccggctt 2635801 ttttcatcac atccatgtta taaaacatga ccgttgtccc tacatgtgta tcgagtccgt 2635861 aaagctttcc gtttttgctg tacaatgtca gccgcgcctc aacgaattta tcgcgatcct 2635921 tttcaatcag cggagtcaag tcggcaagcg gtatgtcaga gcccttcaaa aagtttgaaa 2635981 aacgggccaa ttcgacatct gcaatatcag gaacgccttc tcccgctatt agggagatag 2636041 ataagttatc gtgcatttgt ccatatggat aaacgaccgt attcagctta attttgcggt 2636101 caggatattt tttgttccat tccttcacca tttccacata gaactgctca tgaagcccgt 2636161 taaatgtcca aaaggtcagc tcagtttcac ccgatttgcc ggatgatttt tctgctgaac 2636221 acccggcaat gactaatgtc agcaacatca tgagcacaag aaaacagaca gtcatttttt 2636281 tcatctgcgt taccccttcc attcgaggtg cgggctattc atatagacca tggttgatca 2636341 gcgttttgtt ttcattgatg attcttaatc cggtgcatcg gtctcttaag gtgtgcgcgt 2636401 gtctgaaggc atttttgacg gaatcctgcc cgacaccgat ttcgtcaaaa tacgcagggc 2636461 ctccggctga tctcagccaa tcagccagca cttctcctct cgggagtgtt tgataagccg 2636521 attggatggc ttcccggcgg cttggtgaaa attcgttcag cccgtcatcc tgagcgagct 2636581 ttctgtatgt gtcagttaat aaaacagcgg cacagcccac ctttgcccca tgaagaatct 2636641 gaggccgttt tttctccatt aactccattt caatccaatg tgaaatatga tgctcgccgc 2636701 ctgatgccgg tcgggaatga tctaatgcca gcatgacaag ccccgataca agtaaagact 2636761 ccatcaaaac ccgtatgcca gtttccgttt tcatcgcaat gtcttctgtg tgttcaatgc 2636821 aggcagcaag cgcctcctga acgatcttag ctcctgcagg cgaataaggc tcaccggcaa 2636881 gatgccggga tatttcccaa tctgctaaag acgtgatttt accgagcatg tcaccaaagc 2636941 cagccgccac cattgactgc ggtgccgctt ttaatagatc cagatcagcg aacagcgcag 2637001 atggggcctt cgtttgaatg gttgttttcg tgccgtataa aataatcggc gcaccggctg 2637061 atgtaaaacc gtctacagat ggagcagtcg gataagaaat aaacggcaaa tctctttgaa 2637121 acgccgcaaa gcggacgata tcatgaatcg tgcccgaacc gactgcgatc atgacatccg 2637181 ttggttgttt cgtatggatc agcacatgaa tgagcgatcg ttcatcagct gtcacatctc 2637241 cggcttcatt ttctggaatg atcaggcact cggcctgaaa tccttcttga ttcagtcggt 2637301 tttctaaatc aattcctgca atgcggtgtg tattcgcgtc gcagacaagg acaatatgtt 2637361 gattgttttt tcgttttaca taatccaaaa gcgaatcagc tgcttgctta ccgagaacaa 2637421 tttcttcaac ttttataggc aacgtctttt ctccggcgtt ttcaaaagca cgctgaacgt 2637481 cagctgcgat acgattcata tcagaatccc ctcctcagcc aatttggtta catccttaat 2637541 agaatccagc acataatccg gcgtgtacaa acgctgttca ccctgtttcg cagaaccagt 2637601 tagcactaag gcgcttttca tgccataaag cttccccatc gcaatgtcag attcaatgct 2637661 gtctcctata atcatgcatt catgtgcgga cagccccatt gctgtacagg cagcctccgc 2637721 catcagccat gacggttttc cgacaacaag ttcagtcttc gcttgtgcag aagtctcaat 2637781 tgccccgatc attccggcca catcaatggc atttccgtct tcgttcggaa aagagcggtc 2637841 tttgtttgta gcgataatac gagcgccgcc ggcagccgct tgaaaggctt gatttaaatc 2637901 gtcgtacgtg agcgtttcat gaagggagat cacgagccaa tccgcttcct tcggttcgct 2637961 cgcgttctgc acaccggcca gcctcagctc gtcaaccaag ccttgctccc caagcaccca 2638021 tacctttgaa aaacgataat gttttttcag aaaagccgct gtcacgcttg atgacagaac 2638081 aatgtcgttt acgtccgttt caatccccgc gccaagaagt ttttttctgc acatggcacg 2638141 ggagatattc ccccggttgc ttaaaaagac gattttcttt cccattctcc taagcgtttt 2638201 gatcgcttct cttgctcctt cgatcaactc atttcctctg aatacagtac cgtccaagtc 2638261 aatcagaatg ccagccggtg acacaggcgt atcatgactg gccataatac gcatttgctc 2638321 cgtgttttcg ataaaaatgc ttttcatgca ggactgtatt gattggggtt acatccttgt 2638381 tcagcataat ggagtgatag gccatttcgg caaccgtttc taatacaact gcgttatgaa 2638441 tggcatttaa ggcgtcagtg ccccagcaga acggtccgtg attattcacg agcacacccg 2638501 gcacctgttc gtaattatga tgctgaaagg tttccgctat gacttttcct gtattcagtt 2638561 cgtagtcatg aatgatttct tcatcgtaca tttctcgagt acatggaatc gcactgtcaa 2638621 aataatcagc atgggtcgtg cctaacggag ggatgtctct gcccgattgc gcccagcttg 2638681 tcgcccattg agaatgggta tggacaattc ccccgatatt cggaaaggct ttatatagat 2638741 aaacatgggt aggtgtatct gaagaaggtt taagcgagcc ttcgacgacc tctccatcaa 2638801 ggttcaaaac aaccaagtca tcggctgtca ggtcgctgta ttcgactccg ctaggtttga 2638861 tgacaattct ttctttttca cggtcaatgc cgctgacatt tccccacgta aaggttacca 2638921 gctgatgctc ttgaagcttc aggttggcag ccagcacttc tttttttaat gtttcaagca 2638981 tgctccatca ccctttatca attctttttg gcggcagatg aaaattgaag atttttgatc 2639041 gttttcagac gcttcatgac atggttttct tttccgaaat aatgaaccag ctctttatat 2639101 tcagcgtaca atttttcata aaccgcggcg ttttcggcat ttggcgtata agttatatct 2639161 ttcagttttc ccatgttcgc cgctgccttt ttgatatcat cgtagccgcc tttttctttg 2639221 cctgctgcaa gcgcgccgaa aatggcagat cctaaggctg gggcttgcgg tgaaccagag 2639281 attttaatgt ccatgtttgt cacatccgca taaatctgca tgacaaacgg gtttttctca 2639341 gctattccgc cggctgcgaa cagttcctca atcggaacac cgctttcttt gaatgtttcg 2639401 ataatcatcc gggttccgta agctgtcgct tcaactaacg ctctataaat ctcttcaggc 2639461 ttcgtcagca gtgtcatgcc aagcagcatc cctgttaaat ctgcatcaac aagagttgaa 2639521 cggtttccat tccaccaatc taaagcaagc aagccgcttt caccaggcgc ttgatggttt 2639581 gctttctcac tcagcagctc atgaacgcca atgttttttt cctttgcttc ctcttgataa 2639641 gctggcggga cacatgtttt cacaaaccag tcaaaatgat cgccgacaca ggactgcccg 2639701 gcttcatatc ccgcatagcc cgggagaatt ccgttgtcca caacgccgca cattcctgga 2639761 acgatatgca cctcttcacc aagtagaaca tggcacgtcg aggttcccat aatcatcagc 2639821 attttccctg gctctgtaat gccgaccgcc ggtaccgaaa catgagcgtc cacattggca 2639881 accgcaacag ccgttcccgg gagaagccct gtcagctttg ccattttttc agtcagactg 2639941 ccggcttttt ctcctactga atgaatagaa cctgacaatt tgtcctttgt aatcgttttc 2640001 attgaaggat ttaatttctc aaagaaatca tctgacggat accccgcttt ttcactccac 2640061 atcgctttat accctgcggt acaattgctt cgcttgagcg agccgcacag ctggtacacg 2640121 atccagtccg cagcctcgat gatccggtca gccgcttcat aaatgtgagg cgcttcctcg 2640181 gcaatttgca tgacctttgg aatcatccat tctgatgaaa tttttcctcc gtaccgctgt 2640241 aaaaaagcct ctccttcttc ttccgcgatt tgattgagcc gatcagcatg tttttgggcc 2640301 gcatgatgct tccagagctt cacatagctg tgcggctcct cttcatattc aggcagcatg 2640361 cataacggct gcccgctgct gtcaatagga aggatcgtac atgccgtgaa atcaattcca 2640421 atcccgataa tgtctttcgg gtcaacgccc gtctgttcga gtaaagacgg aatggttgtt 2640481 tccaagactt cgaggtaatc agcagggtgc tgcagcgccc agtcacgcgg cagcttttga 2640541 cccgtttttg gaaggacggt atcaatgaca gcatgcctgt attcttttac agcagccgca 2640601 agttcctccc ctgtttggac atgaacgagc actgctcttc ctgataaagt tccaaaatca 2640661 acccctattg tgtaagccat gtgacatccc cctctacttt tgaagccggt aaagcgcctc 2640721 gttccatttt aactcgtgtt tcagtttatg aattgtcgta tcacgggaaa tgagaacact 2640781 ttcgattccc gccatttccg cccaatcaag catttgctcc gctgtcagtt cataagacag 2640841 gcaggtatgg tgtgcaccgc cggctaaaat ccatgcctcc gctgctgttt tcaatgacgg 2640901 ctccggcttc cagagaacac gggcaaccgg taaattcggc atgtcttttt caatttcctg 2640961 gccgttgact tcattcagca caaggcggaa acgcccgcca atatcaacaa tgctagcttg 2641021 aatggcagaa ccgctgatgc cgttaaatac caaacgcgca gggtcctctt tgccgccaat 2641081 cgaaagcgaa tgaacctcga ttttcggctg atccaaagcg acagtcggac acacttcaag 2641141 catgtgagag cccagaatca tttcatttcc cggttcaaaa tggtacgtgt aatcttccat 2641201 gaaggaagtt ctttttcctt tagccatgat tttcatcatc cgtacaaggg ccgctgtctt 2641261 ccaatctcct tcaccggcaa acccatagcc tttctccatc aggcgctgaa cggcaagtcc 2641321 cggcagctgt ttcattccgt gcagcacttc aaacgatgtc gtaaacgctg tgtatccgcc 2641381 ttgctcaaga aaagcggtta atccaagttc aattttcgcc tgttctttaa tggacgctac 2641441 ctttgcttcg tcacgttttg tttcctcact gatcacatat agtctgtcat actcggcata 2641501 aagcgtgtca acctcgtcgt ccgtaatgcg atccatcact tcaacgagat ccccgatgcc 2641561 atatccgtca acctgccagc caaattgaat atgcgctccc accttgtctc cgtccgttac 2641621 cgcgacatga cgcatgttat ctccaaatct ggcaacctta atatgtctgc tttcatttaa 2641681 tgcagccgcc gtatccatcc actgggacat ttcttttttc acttcttcat catcccaata 2641741 gccggcaatg acttttcggc taagccccat tctcgagttg atgtaaccgt actctcgatc 2641801 gccatgcgcg gattggttgc tgttcataaa atccatgtca atcgtacccc acgggatatc 2641861 gcgattatat tgggtatgca aatgcataag cggtttttga taagaggaaa ggccttctat 2641921 ccacattttt gcaggggaaa atgtgtgcat ccatgtaatg atgccagcac atgtctcact 2641981 gtactccgct tctcttaaca gctctctaat ggtttccggt gaagtgacga cgggcttatg 2642041 agtgatttta tatctggaag aaatcccgct gagcccctca caaatgcttt tagcatgctg 2642101 atctacgagt tccagcgtct cttccccgta taggtgctgg cttcctgtca caaaccagaa 2642161 ttcataatcc tttgtctgaa gcatgtaaac tgcccctttc tcataaaata aaacgctttc 2642221 aaatacaaaa gatacgtact aatgatagaa aataaaccta taaataaata tttgtacgaa 2642281 caattttatt atagtaattg actattatac tgtcaatctt ttcttttaaa aaaagccggg 2642341 ggcagagccc ggctttttaa ttcaatagga cggccagccc gagctccaat tcaaatcatt 2642401 gatgagaagc tttggaatgc cgttgtcatt ggcatcatag gcatggcgaa caagaatgtt 2642461 tccgttcaca atatcctggc ctccaggtcc tttccattgg tcattgcccg aatccaaaat 2642521 ggtgcctccg ccttcaagca tgctttttcc gcttttatca agataagggc ctgtaatgct 2642581 tttggatctt ccgtaagcaa ttttgtacgt actgtttacc ccgtcacagc atttatcaaa 2642641 tgaaaccatt aaatagtaat atccattttg atacgtaaga gtaggagctt ctaaggcacc 2642701 tccattattc ggtctagctg caatcgaata gagcgagcct gtaggcttca ttgtactctt 2642761 atcgagctta gtcagcttaa tgccgctcca aaacgagccg aatgcaagcc acgggttgcc 2642821 atccttatcg aatgtcagct ccggatcaat ggcgttataa ttatttgagc ttgtcgaacg 2642881 gatcaccaag ccctcgtcct tccagccccc cgaactgatg cttgttgaag atgccaggcc 2642941 aatggcagat gtattgcttc caaaagaaga aacggaataa tatagccagt acttgccgtt 2643001 atagtattgg atgtccggcg cccactggtt ttggccataa ttcggcacat aattggacca 2643061 ccacgatagc ggtgtagtga aaatggattt ttgtacggtc caatttttag cgtctgaaga 2643121 cttcaaaacc cgcagtcccc gttcttcagt aagccctgtt ccgagcgcat accatgagct 2643181 cccctcttta atcatagtcg ggtcatgaag cagctcattg gatgcacccc aaaacgctgc 2643241 ctctgcggga gcagcagaag tgaatatcaa acctgcagcc agagctgcac tcgaaaagtg 2643301 taagaagcgt ttccatgttt ttttcttttt caattttgtt caacctcctt tattttagaa 2643361 agcgcttaca aattagatta tttatcctcc cttcctgtca aatcgactgc gtatcgtata 2643421 tcgtcatgtt caggaaattt tcggtatccc ctttattgta gtcactatgc tgtaatttgt 2643481 acagacaaaa aaatagaatc cacctcaata ggcggattct tccgtatctt tattggtacg 2643541 taatttcgtc aaccgttttt cggtctaact tcttaatgac ttctgtaatt aactttaccg 2643601 cgttttcata atcatcacga tgcagcatgg ccgcgtgcgt atgaatgtag cgggttgcaa 2643661 tggtaatgga cagcgcagga acgccatttg ccgtcaaatg gatggcaccc gaatcagttc 2643721 cgccgccggc aatggcatca aattggtacg gaatgccggc ttcctccgca gtggctacaa 2643781 ctgcatcgcg caaacctttg tgagagacca tggatgcatc gtaaacgata atctgcgggc 2643841 ctttgcccat tttgctctgc gcttccttct cggaaatgcc aggcgtgtct cctgctatcc 2643901 ctacatcaac accaaacgca atatcaggct gaatggtgtg tgcagccgtt ttcgctcccc 2643961 tcagcccgac ttcctcctgc acggttccga cgccatacac tatatttgga tgatctgtgt 2644021 tttgtaagtt tcttaacaca tcaatagcaa tcgcacagcc gatgcggttg tcccaggcct 2644081 ttgcgagtag gaatttttca ttgttcatga ccgtaaattc aaaatgcgga acgatcatat 2644141 ctcccggaag tacaccccac tccaaggctt cttcccggct tgaagctcca atatcaataa 2644201 acatgtcttt tatttccact gatttttttc ttgcttcagg agacaaaata tgaggcggct 2644261 tagatccgat aacccctgtg atttctcctt tttttgtgac aatggtgacg cgctgagcaa 2644321 gcataacctg agcccaccag ccgccaacgg tttgaaaacg gataaagcct ttatctgtga 2644381 tttgtgtcac cataaagccg acttcatcca aatgtccggc gatcataatt ttcgggccgt 2644441 tttctgcacc agtttttttt gcaattaaac tgcccaggcg atctgttgtc acctcatcag 2644501 caaatggttc tatgtatgat ttcatcactt gccttacttc tctttcattg cccggtatgc 2644561 cttttgcatc tgttaaatct ttcagcatgg tcaatgtttc atctaatttt gccatgttcc 2644621 aaaccctcct tcatcagtcc tgcattctta ttatacaaaa catggcgcta accatacgac 2644681 tatttcactt gaaaatcggg tatatgtttt tacagctttc ttttagaaaa agtgaaacct 2644741 ttttctatgc ttttcgtatt acatcagatc atcaccataa gggaggtgcc ttcacacaat 2644801 gtttgtcatg gttctaagga ttattttgct tgcacttttt gcttattgta tttatgccgt 2644861 ggtcaaatat gtcgcgaatc ctaagagaag gcttaagctg gcccaatcaa aagaacattt 2644921 ttatattatt gatgaacaaa acaatacccg gaagaatttt cagctgacgt ataaaggcgt 2644981 gctttttgag ggagaaaagc atattccttc caaggatcat ccgctgttta ttcacacgat 2645041 ctttgtctgg acagaatctc ctgagaagct gaaacatttc tctgcaaaag attttgagaa 2645101 cattgaagaa aaagtgctgg aacgatatcc aaattgtaag attgactggg accagcccat 2645161 taaactcgca aaaaaagcag aagagcgtta aacgcttttc tgctttttat aaatcaaacg 2645221 ggctgtagta aatagcgatg agaatcgctt ctattaccag aagaagcggt actccgtact 2645281 taaaagaagc gtgtttcgtt ttatgtctga aggtttgcat gccaagccag acaccgagcg 2645341 ctccaaacac gatggctatc agccacagcc ggtcttcaga aattctccac ttgtgctgct 2645401 gcgctttgcg tttgtcaatg cccatcaccc aaaaaccgca cagattaatc aacaccaaat 2645461 aagcagcaat aatcatgttg cctcatcctt tatatagaaa aagccgctct gctggagagc 2645521 ggctctatat gattacttgt ttaattgagc tttagcagca tcagcaagct gattgaatgc 2645581 agtaagatcg tttacagcaa gatcagcaag cattttacgg tttacttcga taccagaaag 2645641 cttaagaccg tgcattaaac ggctgtaaga aaggccgttc atgcgagcag ctgcgttgat 2645701 acgagtgatc caaagtttac ggaaatcacg ttttttctga cgacggtcac ggaaagcata 2645761 gtttccagat ttcatgacct gctggttagc tactttgtat aatgtatgtt ttgaaccgaa 2645821 ataacctttt gctaatttaa gaaccttttt acgacgctta cgtgtaacag ttccgccttt 2645881 tactcttggc attgaatttc cctcctaatt gttccttatc cgattacttg atgttagcaa 2645941 gcatttgttt gatacgtttg aagtctcctg cgcttacaac agcactcttg cgaagcttac 2646001 gcttttgctt ttgagatttg ttggcgaata agtgacttgt gtacgcgtga gaacgtttta 2646061 acttcccaga acctgtcttt ttaaaacgtt tagcagatcc gcggtgagtt ttcatttttg 2646121 gcatgggatt tcctccttat tgcttttcgt ttttcggtgc gagcattaag aacatgctgc 2646181 ggccgtccat ttttggtttt gtttcgactg tcgcaacctc agcacatgct tcggagaaac 2646241 ggtctaatac acgctgaccg atttctttat gagtgattgc gcgtccttta aagcggatag 2646301 aagctttcac tttatcgcct ttttcaagga atttaatcgc attgcgcaat ttcgtgttaa 2646361 agtcatgctc atcgattgtc ggacttaacc gaacttcttt taagttaatg attttttgat 2646421 tcttgcgtgc ttctttttcc tttttctgct gctcaaatcg gaacttaccg tagtccatga 2646481 ttcggcagac aggcggtttt gcattcgctg caactaacac aaggtcaaga tttgcgcggc 2646541 cggcgatttc aagtgcttcc tgacgggact tgattccaag ctggtcgcca ttttgtccga 2646601 ttaaacggac ctcacgtgca cggataccct cattaaccaa ttgatctttg ctaataatga 2646661 gccacctcca tagtttcttc gaattgattc acaactcatt ttgaatgcat tttgcaggca 2646721 aacaaaaagt gtgggcatta taaaacaccc acactacgaa catctgtatc aataaaaatg 2646781 tacggtcaac ctgccaacta catgcatgtg tcaatcaggt gagaagcggg tgcttctgct 2646841 tgtgatttat attcaattca ataactattc tacacaatac cggatcttta gtcaaggacg 2646901 acttatccgg aacaactttt acattgtaac atgggttttc tatgagcgca agagagaaaa 2646961 agaaaatctt tcatccccac ccagaataca aagaaccaac aattccccct tattacgcaa 2647021 tttacaacaa aaccaccgac aggaagaaat gtaaaacaaa gttaatctct gaccgatata 2647081 aggagcagaa gggagcctga cacatgaaca aactgataca gcttgcttta tttttcacat 2647141 tgatgttaac cggttgctcg aatagcagca catcttccga atcaaaagtc gaaaccactg 2647201 ttaagacaac ggcagcattt cctcaaaagg agctggagaa agagctaaaa aaactaaaac 2647261 ccgtttcatt ggacatgaag ttcgagagtc cactcgctac cgagttagga aagcggaagg 2647321 caaaagagga agctgaaaag caaagacaaa tcgccgctga gaaaaagctt gaaaaagagc 2647381 gggaggcgaa acgaaagaaa cagcaggagg aaaaagcgga gagacagcga ttagcagagc 2647441 agcaggctgc agagagacag cgattagccg aagcggaaag acaagctgaa cttgaaagac 2647501 agcggcaggc agcaatccaa aaagagcaga aagcgaacgc tgagaaaaag cggcaatcgc 2647561 aggcacaacg gcagcagact gaggcaccct catctaatag tcaagatcca ccatcttcct 2647621 cgagtcagac agataaaacc attcaacagc cagcttcaga gcttcctgat gacgatggtt 2647681 atggttatga agaacgaaaa aagtggcatg acgatcaagt agaatggggc attaaacaag 2647741 ggtatatcga tcccgaagac gcaccataaa ataaaaaaag ccaaggcatt cagccttggc 2647801 ttatcctccg atcagctgca cgaacacagg gatgaccaga accgttacca ctcctactac 2647861 gacaacagca atacttgcca tcgcagcttc aacttctccc atctcaatcc cgaccgctac 2647921 accaagtgca tgtccggatg ttccaagagc caatccttta gaaatcggat ttttcacttt 2647981 aaacaccttc aagaacaatg ctccgagcgc atatacgatg acagcgttaa agatgaccgc 2648041 aaaggctgtg atgtcgctga tgcccccgat gccttttgat aaaggaagcg caattgccgt 2648101 tgtagccgcc tgcggaagca tgcttttcat tacggccgaa tcgagatgaa tgcctttagc 2648161 gagcagataa acaatcgtga cagagcagat agagccggca ataatggagg ccatgatttg 2648221 ccaccagtac tttttaagct tatctctttg tttgtacaaa ggaattgcaa atgcgatcgt 2648281 tgccggttca agaaaaaact taatgatctc tcccccgtta ttataatccg cgtaggaaaa 2648341 accgccgatt tttaaaaatg cgatccccag caccatggca acaaacaaag gagtgaaaag 2648401 gaagaagcct ttcgttttct taaataaaaa ggtgccgatg ccgaatgcag caagtgatac 2648461 gacaatccca aaataaggac tcattgtgct ttccatgtga agaacctcct gtttccctta 2648521 atggtgaacg agttcgttat tgttctgcgg gctttgcact gtttttgttt tcatgtccgc 2648581 ttcggttttg cgttttccgc tcagcgacag aatcagctga gaaaacaatc ccgtagcccc 2648641 cagcaaaata atcgttgcga gcagaatgac aagaacaatt tgcaggccgt attgctgcat 2648701 cacaccaagc gaattcataa cagatatacc tgatggaaca aataaaaatc cgatcagaga 2648761 ggttaaagac gttccgagcg tctccacttg ttccagttta atgactttca aacataatag 2648821 gagaaataat aagaccaacc ctacaaccga tgccgggata ggtattggga caatagcggc 2648881 aatcatattt gaaaccagca taatgacggc aaaaataaat gcttgtgtta aaaacccgta 2648941 cactttttta gcactcattt tcttcacctc tttctctttg gtaccctcat tataaataag 2649001 aattccctgt tataaagcgc ttacaagata acatgccgta tagcgggtct gagttgcaga 2649061 atcaaatggc tgaaatgcaa aaagccgccc atcaaatatg gagcagcttt ttcaattcct 2649121 tcgcatatgt ccggctgacc ggtattttcg atccgtcttt catgatcaga ttatacgttg 2649181 aattaaacca tggctgaatt tctttaatat attcagtatt cacgacaaag ctccgatgga 2649241 cgcggataaa atcagaatcc ggcagctttt tctcaatcac aacgagtgta tcgctgaccg 2649301 tataagaatg atcgaaggtt tttacattga catgaccatc ttctgttccg gcatagataa 2649361 tgtccttcgt atccacaatc acaatcgatt cccccacaga tagcgcgagc ttgtgctggc 2649421 cggcatggct gttttgctct gtttctacaa tatcccgatt gactttttta tattttttca 2649481 gcgtttgctg aattctttct tcatcgaaag gcttggttaa ataatcaaga gcgtccacct 2649541 caaacgcttt gagcgcatac tggtcatacg ctgtcgcaaa cacaatagca ggaggatgct 2649601 tcattttctt caatcgcttt gcgatatcaa aaccgttttc tccggataaa tcaacgtcta 2649661 aaaacagcaa atcaggtttt tgatccatca tttggtcaaa agcggattcg atattttccg 2649721 cttcattgat ttccatttca tcattggtcc gcttaagcaa gtaagccagt tcatcccttg 2649781 ccagcatctc atcatcaact attaacaccc tgagcatgtt cttctccctc tttcatctgt 2649841 tgcattggca cttgaaagga aacctctgtc cctttatgaa cctcactgct gatatgcagt 2649901 gcagcctgct gtccgaataa accgatcagc cgctgattta ggttataaag cgctgtaccg 2649961 gttccctcct tagacggaaa cggtttcttc cccagttccg gcaagacgtc cggcggaatt 2650021 ccgcgtccgt tatccgccac cttcatatag acggatgcat catcagataa gacacagact 2650081 gtaaccttgc atatgtcttg ttttttcgga aacgcgtgcc gaagcgcgtt ctcgacaagc 2650141 acctgcaaaa caaacggagg gatttcaatc tgctccagtc tgctgtcgat attaagctca 2650201 attttatatt tcccgggaaa acgcgcctgt tctaatgaca aataggcgtt aagatggttc 2650261 agctcctttg agagcggaat cagcagctgt ctcgctcctt gaaggtttga acgaaaataa 2650321 acactgagct gcaataggag cttacgggtt ttttcaacat ctgtacggca taacgcagaa 2650381 atcgtgttga tcgcattaaa taaaaaatgc ggattcacct gtgcttgaag cgctttaatt 2650441 tcagcatcct tgagaagttt gctttgcagc tctgcttccc caagctcaag ctgtgtcgaa 2650501 aacagcatgg ccagcccctc ggcaagttcc tcctctacct gactcaggcc tgccgggctt 2650561 ttaaagtaca tttttaaggt gccgattgta ttgccgttcg atgtcagcgg taggacaatt 2650621 gcagcgtgca aagggcattc agcatgcgtg cattcaatct cttcctgcga aatcgccttc 2650681 ataatatgcc ctgttttaat cacctttttg gacaggccgg tgatcaagct tttcgatggg 2650741 atgtggtgat ccattcccgc accgacatgc gcaaggatct tttctttgtc agtgagagac 2650801 accgcatctg ttcctgtcag cttatggata atagccgcta cacttttaca ggagttttca 2650861 tttaatcctt ggcggaaaaa tggaagtgtc tgatcagcaa tcgtaagcac tcgatgcgtt 2650921 tcgagagccc ttgcctgttc ttccttgcga atgatcgctt gaataataga cagaaaaata 2650981 aaactgcctg ttccattgat gagtatcatc ggaattccga tcatgctgac aagctcccaa 2651041 gcgtcactga acggctttgc catcagcaaa ataatgatca tttgcagtga ctccatgccg 2651101 attcccacaa gagcggcgat gcgcggtgtc ggcattcgat atcgcttcgt aaaatacctg 2651161 ccgatcaagc ctgcaagaac acccgctaaa atagatgaga cggcacagct taaggccgtg 2651221 ctgccaccga gtgaaaaacg atgcaggccc gcaagtatgc cgatcccagc ccctacaaaa 2651281 ggacctccga gaaggccccc gatttccacg cccaaaatac gggtattcgc gatagagccc 2651341 gatggatcta tcgtaaacac ccagtcattg tttacaatca tatttctttg aatttcgatg 2651401 cctgtataat tgctgatgat gctgaaaaga gaaaaaatag aaattaaaat cgcttttcct 2651461 ttatagccgt cctgattctg aagagcttgt ctgaaaagtt tcgtatgggc gagaatgaac 2651521 cctaatataa caataatccc cactctctcc agcatcataa tcattaaatg aatcattcat 2651581 gtcacctgtt ctttccgttt tcattctagc atgttttcgt tttgcggctg actgtttttt 2651641 taaaatcgtc tgaaaacata tttcacaagg cttttatcta ttgtaaaata aaacatgagc 2651701 cttttggcag aaagatttga atctgaagca gaggagaaga tcatgaaagc cgtatttttt 2651761 gatttagatg atacactact ttgggacgaa aaaagcgtca gaacaacatt tgcagaaact 2651821 tgcttacagg cggagaaaaa atatggcctt gcccctgagg aattcgaagc agctgttcgc 2651881 gaagcggcga gagaattgta catgtcatat gagacgtatc catatacagt gatgatcggc 2651941 attaacccgt ttgaaggact gtggtccaat ttctcagagc caatcagtga aggctttcaa 2652001 aagctgaaca agattgtgcc ggagtacaga agaaatgcat ggaccaacgg actgaaagcg 2652061 cttgggatcg atgatcctgc atatggcgaa tacttgggag agttttttgc ggcagagcgc 2652121 agaaagcgcc cgtttgtata tgatgaaact tttgctgtac tcgatcaatt aaaaggcaag 2652181 tatgaattat tgcttttgac aaatggcgat cctagtctgc aaaaggagaa gcttgccggc 2652241 gtgcctgagc tcgctcctta cttcaatgaa atcgtcatct cgggcgcatt cggcaagggc 2652301 aagccggatg tttcaatttt tgaacactgc cttaagctga tgaatattga aaaagacgat 2652361 gccatcatgg tcggcgataa tttgaatact gatattttag gcgcttcaag agccggaatc 2652421 aaaaccgttt ggatcaaccg gactgataag aaaaacgaaa ctgacgtaaa gcctgattac 2652481 atcatcagca gccttcatga tttgtttcct atattagaga aataaaaaaa gcatgatctc 2652541 ttcaatgaga tcatgctttt ttattttatt ttttcgcttc agctactgcc tttttcacaa 2652601 actcatcaag tgaaatggtt tcagagttct gttctccgta tttacgcacg tttaccgctc 2652661 cgttttctgc ttcttggtca ccgaccacca gcatgtacgg gattttttgc atttgcgctt 2652721 cacggatttt gtagccgatt ttttcatcgc ggctgtcgac ttcaacacgc aggccttcac 2652781 attgcaggcg ttcctgcact tttttcgcgt agtctaaatg cacagccgga gaaaccggga 2652841 tgacttggaa ctgaaccggt gcaagccatg tcggcagcgc gcctttgtgt tcttcgatta 2652901 agaaagcaac aaagcgttcc attgttgaaa cgacacctct gtgaatgaca accggacggt 2652961 gctgcttgcc gtcctcaccg atgtatgtca ggtcgaaacg ttccggcaat aagaaatcaa 2653021 gctgaaccgt agacagtgtt tcttcttttc cgatcgcagt tttcacctga acatcaagtt 2653081 taggtccgta gaatgccgct tcaccttctg cttcgtaata gtcgtggccg atttcatcca 2653141 ttgcctcttt cagcatggat tgcgctttgt tccacatttc atcgtcatca aaatatttct 2653201 ctgtatcttc cggatcgcgg taagacagac ggaatgtgta atcacttaaa ccgaagtctt 2653261 cataaacatc ctggattaaa cggactgtac ggataaactc atccttaatt tgatccgggc 2653321 gcacaaagat gtgtgcatca tttaacgtca ttccgcgtac ccgttgaagt cctgacagcg 2653381 cacctgacat ttcatagcgg tgcatcgttc caagctctgc aatacgaatc ggaagctcgc 2653441 ggtaactgtg aatgtcttgt ttgtaaatca tcatatggtg cggacagttc atcggacgca 2653501 atacaagtgt ttcattgtcc atttccatcg gagggaacat gccttcctga taatgatccc 2653561 agtgtcctga tgtttcatac agctctttgc tgcctagcac aggtgtgtat acgtgctcat 2653621 agccgaggct gatttcttta tcgacaatgt agcgctcgat gacgcggcgg attgttgcgc 2653681 cttttggcag ccaaagcggc aggccttgtc cgactttttg agagttcgcg aacagcttta 2653741 attctttgcc aagctttctg tggtcgcgtt ctttcgcttc ttctagcata cgaagatgct 2653801 cttcaagatc agcttttttg aagaaagctg taccatatac gcgctgaagc atttggtttt 2653861 tgctgtcacc gcgccagtat gcgcctgcaa ggcttaacag cttaaattct ttgatttttc 2653921 cggttgaagg aacatggacg ccgcggcaca ggtcaaagaa ttcgccttgc tcatagatcg 2653981 aaacggtttc tccttcagga atcgcatcca atagttcaag cttcaggtcg tcgccgattt 2654041 ccgcaaaacg ggctttcgct tcttcacggc tgacttcttt tcgaacgatc ggaaggttcg 2654101 cattaacgat ttttttcatt tctttctcga ttttcggcag atcctccggt gtaatcgctt 2654161 cgtccatttc tacatcgtag taaaaaccgt tttcgataac cggaccgacg ccgaatttaa 2654221 catccttgta gatgcgttta atcgcttgag ccagcaagtg agccgcactg tggcgcataa 2654281 tttgaagacc ttcttctgag ccttctgtaa tgatttccac tgtaccgtct tcattgatcg 2654341 gcgttctcaa atcgatttct tttccgttca gttttccggc taatgacttt ttctttaatc 2654401 ccggactgat ggatgccgcg atatcttctg ttgttgttcc tttcgcaaac tccttgactg 2654461 ctccatcagg aaatgtgatt tttaccatat ctgacatctt tgtcactcct ttttttgcat 2654521 ataaaaaccc cgccccctat gaaagggacg aggttgaata aacggaatcg tggttccacc 2654581 cttttttccg caaagccaat acacggcacc tgcggctcta agctctgtaa cgggagttcc 2654641 cgtcagccat tactgttcct tttcaagagg ttcacagctg aagttcaaag gcggtaaagc 2654701 gaatggtcct tagctgggaa gcttgcagcc agggcttccc tctctttgag ccggtatcat 2654761 tccttcgtgt ccttatcaat acgtgtgtct ttcttaatct cctatgtatt ataaattgtt 2654821 caatccaaaa aatcaacacg atcgcgtttc ctttttttta aaccgacagc cttaaataga 2654881 caggctgccg gccctcatcc ttccgagtgc ttcaccggta tttctgcatc tgtaaaagca 2654941 tgcagcggga gcatttccac tctctcttga aatacgtttt gaatggtcct tgccatcatg 2655001 tgctcgggct ggtcggtata aagcacgact tcatcaggcg caatggaaat cagcggcgcg 2655061 agcaaatgag aatcaatata cataggatga tcccggacaa atcttctgtc tatgtatttc 2655121 attttttccc gttccggcac atagcgcagc tcccataatg taaaggaacc atcatggaca 2655181 atatgcactt ttttgattcg cggctgtttg gcgtccacat agtctctgag tgtttgaata 2655241 aagttttgat attcctgttc catcttatat tcatcaatcg ctgcttctgt aatatctctc 2655301 agctgcttat agtatgatcc aagtcggaag gtctgaaagg agcgaatgta aaatactcct 2655361 tcctctaaac agatcgtttg gagttcatcc aaaattgatt gtttccgtga aagcttcagc 2655421 ggctcaaacg gaagatcgtc tgcttcacct tcaataatac tgtgtgcgag ctgaaggatt 2655481 tgctgctgtt catcctggtc cgtgaaacaa tacgtttcct caatcaatga cagcatatgc 2655541 tcgtcttctt tgcattccaa aaaaaatttg accagaatcg gctccataaa acgctgaata 2655601 ggaaaagccg gattcgcttt ttcaatcccg atttttcgta tgccttcacg gacaatgata 2655661 ttgttccgat cgtccgaatg ctgaatgaga tgtaaaaaag cggctgcatc atggtcatct 2655721 tcaaagatta tttcaagcat gtttgtcccc ccttacggca tctgttacaa gtatatgggg 2655781 gatgttttta aaatagacgt aaaggtcatt ggcaaatctt aatttgattc ttggaacaag 2655841 ttttgcattt tctttctgaa gatgaacggc aatgagataa acacgatata caaagcgagc 2655901 accataaaga aagcgggcag attgccagcc aaaaagctcg cacccagcac attaagcgca 2655961 atcgtcccag ggatgattcc cacagccgtt gcggcaaaat acggcagcgc tttgacattg 2656021 gaaaggcctg ccgcatagct gacgaaatca aaattgatcg gcaggattct caaaagaaag 2656081 atatagaaaa atccgttatc ctccatttgc ttctgtatgg cttcaagcct ttcgtaatgc 2656141 ccgttctttt tcgccgaaaa caaaccagcc gcaaaaaacg aaacagctga agcgcacatc 2656201 gaaccgaata acgtataaag cgtgccgaga agcgggccaa acgcaagtcc gccagctatt 2656261 gaaataacag acaccggaaa taaaacaagt ggcctgacga tggatatccc gataaacatc 2656321 agaggtgcaa agactccgaa cgacaatacc cataccctga tttctttcgg cgatacattc 2656381 aaatacgttt tatttcccca atagagtaaa ccagcacctg caagcactgc cagccatttg 2656441 acagccgttt ttcgtttcat accctcagtt ccttcccctt tgaaccacag caattatgga 2656501 tgtcggcggt tttctccgtc aaggcggatc ggagcagcca aatataatat ccgctccatt 2656561 aatcttgcag cttttacttc ttctttttct cccctctgcg aatacgtaaa atgatgcttc 2656621 agctcgtcag gtgagaaatt agaagaaaag aacgttggca gctgctggga cattctgtgc 2656681 tgaagcaccg ttccgatgac ctcatccctt acccagcttg tcattgattc tgctccgatg 2656741 tcatcaagca ttaatacggg tgtggtcttt accatattga gcttctcttc caatgtctgg 2656801 tcttgcagcg aattcttaag ctctctcaca aattcaggca cataaacaat catggaggaa 2656861 tactcttttt ccgccagctc attggcaatt gcagcgagca taaacgtttt tcctacccca 2656921 aatttcccgt ataaatataa tcctttccct tttcccgtct cattatagct tttcaggaag 2656981 tctgtaacat gctgaaacat cgcgagtctg cttgggtcac tgatatcaac ttgctggaac 2657041 gtcgctccaa gaagatcctg ctggatatac atgcttttca taagagactg ttgtttcttc 2657101 tgctggtcga gcttccgttt gactggacat tcgtaatact cgatatcaat agacctccca 2657161 ttgacaacaa gcttcggatg gtagccctcc aacaaattgt tgcagttttc atcttccgaa 2657221 caataggagc aattcttgct ttgttcgata tattcataaa gcttatttaa gctcttttcg 2657281 atcatttttt ggtcaatcac ttcttcgttt tccttcaaaa atgcttgaac atcttgatct 2657341 ttcatgactt tttccttcat ttgttcaaga cgtttttgga aatccggcct gccggttacg 2657401 ccctgcaggg aacggccgat tggttccatc tattccttca ccccgcatct ctgtctttaa 2657461 taggcagagt attttttcag tttttgcatt tcttccatca tctttttctt ctgttcttcc 2657521 aaatcctgcg gatgcagctt ctgctgtccg gattctgaat cggacgctgt ttccttttct 2657581 gtcatccaat caggaagctt ttcttcacga atcacttttt ggtttcgttt cgaagacttt 2657641 gtttttccct cagcccattc aagatactgg cggttttctt ctattgcgag cttcatcgct 2657701 tccctgaccg ttttcacctt tttgcgtgcc caatgcgaag cgattttttg gatatagttt 2657761 ttcgacagct tcatgtcggt tttcagcatg acataataaa ttaacacatt tgtgacgcct 2657821 ggctcgagct tctgttcgaa cataatttct tctatgatct tcagatcagc ttttgacggc 2657881 tctgttccgt cagcaatgtc ctgcagaagc ttcttcgggg aaatcgcctc cagcaatgca 2657941 atcagcttcc catccagaga atcctcttct gccggttgtt cgccttcacg cagatgcacc 2658001 ggctgtgttt tttccaccaa atcgggcagc tgtccgtttc tttcaatttg ataccagtcg 2658061 ctcgccgctt ttcttaatgc ctccgtcgta atgacgtcac gctcatcaat tgcgctcatc 2658121 acaacatttt gcatttgcaa agggtcaatt ccgtacagat aagaaagctt tttgattgtg 2658181 tcccgcacct gctgggtcat cgcttttctc ggtatcatcg tctcagaaag tcccgctaaa 2658241 aacaaatcaa aatcaaacac atcctccgtt atggtgtagg acggagactg tccgacagaa 2658301 gtatactcgg acccctcggc aagccttacc gtttcctcca tatcggatgt gagcttccat 2658361 tcactcggct gcagcgattc aaacgcatga ttaaacggac gcgtaatgtc cttcgcatct 2658421 tctgaaatgg ccgggtgcgt aaaaaattgt tttaattgct gatatttcgt ttttccgacc 2658481 ctattataca gaaaaacatt cagcattccg tcttcaaaaa attcatttgg tctgagcggc 2658541 ggaaggagtt catatataaa gaggcgctcc tgccgctcgg attctttcat atatactttc 2658601 agcaatccga tgccctcgag cttcccctgt tcctgatgga tcgtttttaa gttggactgt 2658661 gtcatcccca tcagctgtct atgtgtggac tctccgcccc acagacggtt ttgttcaagc 2658721 tctccccaca atgtcatata aagagagaat gcaacagggc cgattaaggg ctggtacagt 2658781 tgtgtaataa tttgtctgtc aatatcctgc agcatcgatc tgcttttaac cacatacggg 2658841 tctacaggca gtacatcttt ccaatagtca gccatacatt ctcaaacctt ccgaatttgt 2658901 ttctaccttt cattttacac cgtttcttat atctatcaaa tgccaatttt gcacatgaga 2658961 aaagagctag aagaatcctc ttagctcttt taacgctctt tctttattaa gtcttttaat 2659021 tcatcgataa agacgtttat atctttaaac tgccgataga cggacgcgaa ccgcacatat 2659081 gcgacttcgt caatcttagc cagccggtcc atgaccattt ctccgacgag ctcactcttc 2659141 acctcggagc agccttgatt gcgaagttct ttttcaatat caaagcacat gtcttcaagc 2659201 gttttgagtg aaacaggcct tttttcacat gcttttatga ggccgcgcag cattttttct 2659261 ctgctgaatt cctcacgcac accttctttt ttcacaacga tgagcggggt ttcctccact 2659321 ttctcaaagg tcgtaaaccg gtagtggcag gattcgcact cgcgtcttcg gcgaatcgac 2659381 tttccgtcat ccacaggccg tgaatcaagg actcgtgttc cgttatgctg gcatgaagga 2659441 catttcaata aaatcagctc ccaactatat cgttccctgc aatgtatttt cggcagcctc 2659501 cgccttttaa aaatagatgt gacagcatct gtcgggagag ccgttgttaa atttgtttct 2659561 atagcattag gtggtttgtg aaaatctcct tcttatttta caaaaaaaat gaaaaaagaa 2659621 aaagctgaca ctctcgtttc tttataaaaa taaaaggagc ataagctaaa aagcgcataa 2659681 tggctttcta gcttcagctc cctttgtgtt cgcaatttac tttatagtac tttcgcttgc 2659741 gcctgtttaa tttgcacagg ccccattcct cttggtattt caatgttttc tcttgtatca 2659801 gcatgtaatg cctctgcaat gtaatcagca gcgacattag gatctaagtc tccacaagta 2659861 taaacatcaa tgctcgcata tccgtgctca ggaaaactgt gaatcgttaa gtgtgattca 2659921 gaaataatca caactccgct tacgccttgc ggtgcaaatt tgtgaaatgc aacctcgcgc 2659981 acctcagcac ctgattttag agcagcattt acaaacgttt tttcaataaa atccatgtca 2660041 ttcagcttat caaaatcgca tccccatagc tcggagataa cgtgacgccc cattgtttcc 2660101 atagtcatgg acccccctta acaagaatta aaaagtgaaa ttccaacaac tgggtcggcc 2660161 atttaccacg ggggaaagtt agtccggaga ggtcctaacc ctttaagtaa ttccgaaaca 2660221 gtctcaagca agaagttcac gaaaaatagt atactgtgtt taagtctaat ttgcaaggtg 2660281 cgttttttca gaaatatgct gttaagggtt ttttctttaa aatgtgtcca tgaccttatt 2660341 ttatacagca gacggatgtt tcattcgtgc cgctacatgg cggattagat caacaactct 2660401 gcaggagtag ccccattcgt tgtcatacca cgccagcacc tttactttcc tgtcttccat 2660461 taccattgtt gtaagcccgt caatgaccgc tgaatgcgga ttcgtattat aatcagtcga 2660521 aacgagcggt tcatctgagt aatcaagtac accgtacatc gacgttttgg cagcgcgttt 2660581 aaatgcctcg tttacttctt cagccgtaac atccgttttc agatcaacaa cgagatcaac 2660641 caatgagacg ttcggaacag ggacacgcaa ggcgaggccg tgaagttttc ctttcagatg 2660701 cggcagcaca agcgaaagcg cctttgccgc tcctgttgtt gttggaatga tggattcacc 2660761 gcaagcccgc gcccggcgca aatctttgtg cgggttatca atattttttt ggtcattcgt 2660821 atacgcatga actgtagtca tcagaccgct ctcaatgcca aactcttcat ccagcacttt 2660881 tacaacaggc gcaaggcaat ttgtcgtgca tgacgcattt gaaataatga catggcgctc 2660941 agcgtcgaat tggtcctcat ttacgcccat cacaatggta acgtcttcat tttttcccgg 2661001 agcggtcaaa atcacttttt ttgcacctgc ttctatatgg cccatcgctt tatctttagc 2661061 attaaacttc cctgttgctt cgacgactat gtcaatatca tattcccgcc aaggcagctg 2661121 ttttggatca cggctgttta acaaaagcac tttctttcca tttacgatca ggctatcttc 2661181 accagccaca acctctttgt cgtatctgcc gtgaattgtg tcatacttta ttaaatgagc 2661241 cagcgtttct gcggaatagc tggcgttaat ggccactact tgaatttgat cgtctaacat 2661301 cgcttttcta aaaaccattc ttccgattct tccaaacccg ttgatcgcta cttttacctt 2661361 catgttggac accccttatc aattatgcca tcctaatttg ttactatcta aaattagtat 2661421 aacacattaa aacaaattcg ccagtacata ttgataaaaa tcaacgatta taacgctaat 2661481 ttatgatgca tcttatgttt tcttgcacag aatatcaggc gtaagaacca aaaagcagcc 2661541 agcgctccgc actgactgcc ctcatgcttt atgattcctg ttttaactta tcattgagca 2661601 cactttcttc tagcacagaa aatgtatccc cgtacactct gttaatatga ttcgctcccc 2661661 aagcacacag catatctaaa atcccttcta agctgcggcc gtattcgctg agctcgtatt 2661721 ccactttggg aggaacttga ttatatacga ttcggttaat gacaccgtcc gcttccagct 2661781 cgcgcagctg ctgagtcagc attttttgcg tgatattggg cattaggcgt tttaattcac 2661841 ttgtgcgttt ttttccgtgc gtcagatggc ataaaatgac gcatttccat ttcccaccga 2661901 tcacttcaag agtcgcttca acagaaatgt tatatttttt cttctccata caatccattc 2661961 tcctcacagg caccaaaaag tgactatagc acttcaaagt acgtactttt atttcttaac 2662021 gatatgtttc ataatcacat ttgccggctg atttgaatct gctctttttt atttatatag 2662081 cttactcggc agaatttcaa tcatacaaca catcttacaa aggaggaaca tcatgacttc 2662141 agccaataaa agcaatattc ctgcactact ggctttggcc gtaagtgcat tcgcaatagg 2662201 gacaactgaa tttatcagtg tcggcctttt gccgctcatt gctgatgacc tggatattcc 2662261 cgtcacgaca gcaggattga ccgtttccct ttatgcgctc ggcgttacat ttggggcacc 2662321 tatattaact tcattgacct caagcatgtc acgtaagaca ctattgcttt ggatcatgtt 2662381 tatttttatt gccggtaata cgatggcagc aaccgcttca agcatcggga ttttactagc 2662441 agcacgtgtg atatcggcat tttcgcacgg tgtgtttatg tcgatcggtt cgacaatcgc 2662501 agcggatatt gtcccggagg ataaaagggc tagcgcgatt tcaattatgt ttactggcct 2662561 cactgtggca actgtaaccg gagttccttt tgggacattt atcggccagc agttcggctg 2662621 gcgtttcgcc tttatggtca ttatcgccgt cggaatcatt gctttcatta caaatggcat 2662681 tcttgtaccg tccaaattac gaaaagggac gaaaacaacg atgcgggatc aattgaagct 2662741 tgtgacaaac agccggttat tgcttttatt tgtcattaca gcgcttggat acggaggaac 2662801 attcgttgtg ttcacgtatc tgtctcccct gcttcaggaa gtaacaggct tcaaagccgg 2662861 gactgttgca gtgattctgc tcggatacgg aatagctatt gctatcggca atatgattgg 2662921 cggaaagctg tcaaaccgaa atccgattgc cgctttattc tatatgttta tcgtacaggc 2662981 aatcgttcta ttcgtactga catttacagc cccgtatcaa gcagcagggc tcattaccat 2663041 tctctgtatg ggattgctgg cctttatgaa cgtgcccggc cttcaggtgt atgtcgtcat 2663101 gctggctgag cgttttgtcc cgagtgcagt tgacgtcgca tccgcgatga atatcgctgc 2663161 ctttaatgca gggatcgcgc ttgggtcata ccttggcggt gtgatcaccg attcaatcgg 2663221 attgattcat accgcttgga taggcggatt aatggtggtc ggtgcagtca ttttaacagg 2663281 ctggagccgc ttgatggaaa aacgagatcg gcaggaagcc tgacaatttt aaaggaggaa 2663341 ataaacatga caacacattt acaagcaaaa gcaacacttc ataatggggt agaaatgcct 2663401 tggttcggcc tcggcgtgtt ccaagtggaa gaaggatctg aactggtaaa cgcagttaaa 2663461 actgccattg ttcacgggta ccgcagtatt gatactgcag caatctatgg aaatgaagct 2663521 ggagtcggag aagggattcg ggaaggcatt gaagaagcag gcatttcaag agaggatctg 2663581 tttatcacat cgaaagtatg gaatgcggat ttaggctacg aagaaacact cgccgcgttt 2663641 gaaacaagtc tgtccaaact cggtctggat tatttggatc tatacctcat ccactggcct 2663701 gtagaaggaa agtataaaga agcttggaga gcgcttgaaa cgctgtataa agaaggccgt 2663761 atcaaagcga ttggcgtaag caacttccaa attcaccatc ttgaagatct gatgacggca 2663821 gctgaaatta agcctatgat taaccaagtg gaatttcacc cgcgcctcac acaaaaagag 2663881 ttgataagat actgccaaaa tcagggcatc cagatggagg cttggtcacc tttaatgcag 2663941 ggacagctgc tggatcaccc tgtattggct gacatcgctc aaacatataa taaatctgtc 2664001 gcacaaatta ttttgcgctg ggatctgcag catggcatta taacgattcc taaatcaacg 2664061 aaggaacacc gcattaaaga aaatgcaagc gtatttgact ttgaattaac gcaggatgac 2664121 atgaaccgaa tcgatgcact gaatgaaaac ttgcgcgtcg gtcctgatcc ggacaacttt 2664181 gatttttaat ggccaaaaaa caccgttcaa tatgaacggt gttttttgta ttatgcccag 2664241 ctgttcatga tttcatcaag ctgccttttg gtctcttcaa gcgtgccgct gttatcaatg 2664301 acttgatctg ctcttgctgt tttttcctct aagggcattt gagagcggat acggctgact 2664361 gcttcttctt ctgtcagctg attgcgcttc atcagacgtt ccagttgaag ctcttttgtc 2664421 acactgacca caataatttt atcaaccaat gattccaatt tgctttcgaa caatagcggg 2664481 atatccaata caacaaatgc ctcccgattt gcaacggctt catcacggcg attgagcatt 2664541 tcctgcctga ctgcgggatg aacaattgca tttaaagcga gacgtttttg ttcatttgta 2664601 aataccagcg ctccaagctt ttttctatct atatcgccat ttgagagcag tatgtcttca 2664661 ccgaattcgt caatgatttg ccggtaggcc ggcatccctt tttctaccgc ttgttttgca 2664721 atgatatctg catctataac tgttattcct ttttcaatca gcatattggc taccgtgctt 2664781 ttgccgctag ctattcctcc cgttaaacca atgactaagg tcaagagatc cactcctttt 2664841 tacaatttcc agagcccaat cgtgattaat agaagccccg gcaaaaacgc cattttatcg 2664901 atccatttcc acttagacag aaaatggccg gcattgattc caattgatac aaacagcgag 2664961 ctcatgattg ccacggcgat gctcatcaca atcggcgaaa aaccgagaat ggctgcgcct 2665021 atacctgctc caaaggcatc aatcgataag gcaaatccca ataagaccgc ctcaattccg 2665081 ttgatcacac ccgatttgtc gatatccgca ctcatgggtt ttctcaaaat atgaatcaca 2665141 attcctaatg accgaacctc tagattaagc agtgtttttt catgcaatag gtattcttta 2665201 tcttttgccg gtttgaaaaa ttgatacaga acccacgcac cgattccaac caatatcaaa 2665261 ccgccaagct tctccgtcac atatacagga aaaaacttcg tgagaaagct tccgatcagc 2665321 atggatataa acatgacagc accggaacag caggcgataa ccaaaatcgc tttaaacggt 2665381 attttcattt ttctcaatcc gtacgtaaat ccgactgaaa aactgtccaa gctgacagcc 2665441 aacgccagca gcagtataga aaccatttgc atatccgttt cttcctttct gttggtgctc 2665501 ttgtatcaga tgtgaaatgc ccgggattca tcacaatcat atatatggga aagtgaaaaa 2665561 tccgtgtttc gaaaatggca tccttaatcc agagttactg atatatgcac cgacagcttg 2665621 gacaatgaag cattatgcta cttttttgtc tggcactttg cgcaaaaatg cgtgcctctt 2665681 cctccaacga caattttcga aatcatcgtt ccgcaatttt tgcatggctc gtcttttttt 2665741 ccgtacacaa aatgctgcag ctggaacatt ccgatttccc cttgggagtt gatatatgaa 2665801 cggactgtgc ttccgcccgc atcaatcgcc tcctgcagag tgtttttgat ttcagcgtga 2665861 agggttttga ttgttttatc tgataattga tttgcttttg tctcgggatg gacacccgct 2665921 ctgaaaagag cctcatccac ataaatgttc ccgagtccaa ctaccgtttt ttgatccagt 2665981 agggcagttt tgacagcgcg gtttgttttc gcaagccggt cttttaaata cgcacttgta 2666041 aattcttctg catccggctc cggccctaac tgagaaagcg ggagctcgcc cgcttcttct 2666101 cccggtttaa ataagtgcat ggttccaaat ttccgcacat ccctgtaccg gagctgggtt 2666161 ccatccgtca tcgtgaatat gacatgcacg tgtttatcgt caggctcctc ggcttgatga 2666221 agaccgtatt ttccttccat tcgaaggtga gaaaccataa cataatgatc taaatgaaac 2666281 agtaaaaact ttccccgtct tccgatggac tgtatcgttt ctcctgctag ttttcgcgca 2666341 aattcctccg gttcggcagg ccgtttgatg atattcggcc atctgatctc taccgatttg 2666401 attgtttttc cctttacaag cccggtcaga gtgcgccgga ccgtctcaac ctctggtaat 2666461 tccggcacat ccatcacttc ctatctctgt ttatttcgca tcgtaccaag atgggcctga 2666521 tgcaaagtcc acctttaacg gcacatctaa tgcaagcgca tgctccatca cttcaggaac 2666581 aagcttttca agaatttcaa tttcttcctt tggcgcctca aaaatcaatt catcgtgtac 2666641 ttgaagcaga agccttgctt tcaactgttt ttctttcagc ttggcagcca tgtcaatcat 2666701 ggcttttttg ataatatcag cggcgcttcc ttgaatcggc gtattcatgg ccgtccgctc 2666761 cgcaaaactt cggatattaa agttccggct cgtcagctca gggatgtagc ggcggcgatg 2666821 cataagcgtt gttacgtatc ctttttgttt cgcttcctgt actgaatctt ccatgtacgc 2666881 ttttacgcct tggaagcttt ccagatagcg gtcgataaat gctcccgctt ccttccgggt 2666941 aatgccgagg ttctgtgaca gaccgtaatc gctgatcccg taaacaatgc caaagttgac 2667001 cgctttcgcc tggcgtctca tcgcagatgt cacttcatcc ttagcgacat ggaacacatc 2667061 cattgccgtt ttcgtgtgaa tatccatatc attagtaaaa gcttcgatca gattttcatc 2667121 ctttgaaata tgggcaagca cccgcagctc gatttgtgaa taatcggctg caaaaatgag 2667181 ccagtctttt tcagacggca caaaagcttg gcgaattttc cgcccttcct caagcctgat 2667241 cggaatgttt tgcaggttcg gatcagtcga gctgagacgg ccagtttgcg ttaaggcctg 2667301 gttaaatcgc gtgtgcactt tatgcgaatc cggtctcgtc acctttaaaa gcccttcgat 2667361 atatgttgat tgaagcttgc caatttgtct gtactgtaaa atatagtcga caatatcatg 2667421 cttgtcagcc agcttttcaa gcacatcggc agacgtagaa tagcctgttt tcgttttctt 2667481 tacgacagga aggccgatct tttcaaataa gatgacgcct agctgtttcg gagaattgat 2667541 gttaaacggc tctcccgcaa tctcatggat tttttcttca tattccttca gcttcgcacc 2667601 cagttcttca cccatccgtt ttaaacggtc aacatcgacc ttgacgccag ttgattccat 2667661 ttcgccaaga ataagcgcaa gaggcatttc cagctcttca aacagttcaa gctggtcgtt 2667721 gttttccagc tcttgaacga gcttttcccg aaggctttga atcgctaacg cttttcggcc 2667781 aaggtgctca gacagtacgt cttctgacgg cactgcccgt tttgctcctt ttccataaac 2667841 tgattcatca cttgaaacga tatgcaggcc gtaatcctta gccacactcg caacgtcgtc 2667901 atatgaattg cccgggttga tgatataagc cgcaaggagc gtatcaaact cggctccttt 2667961 cagctcaatg ccctgccagc gcaaagcgac aacggcccgc ttgctgtcga agacccattt 2668021 cttctgctcg tcattttcca cccattcttt aaacacctca gactcaacgg caatgtcttt 2668081 cggaatgaaa taagctcccg tttcatttac gatcgaaaat ccgaggatcg gctcttcatg 2668141 ataattatcg ccaatctgtt caacgacaaa tgcggatgga gaaaccaata tatcgcttgt 2668201 cacgtctgtg actgttttga cattaatgtc ttccaacgat tgatcctgtt ctgcttctgc 2668261 actgtcttct ccaagccgtt caagaagcgt gttgaagcca agatctttaa agatggcaat 2668321 gacctgttca cgattaaagc cttgatattc caggccggaa acagatacct caatcggagc 2668381 atccgtcata attgtcgcaa gctccttgct catcaatgcc tgatccttaa actcctcaag 2668441 cttttccttc aatttctttc cgctcacctc gtcaatggac tccagcagct tttcaacgga 2668501 atcaaattgt tttaaaagct taatcgcagt cttttctccg acgccgggca cacccggaat 2668561 attatctgag gaatcgccca tcagaccctt catgtcaatg atttgttcag gcgtaagccc 2668621 atatttctct ttgacatgct ccggtgtgta aaattcaaca tcggtaattc cctttctcgt 2668681 aatggcaact gtcgttttgt ccgttgccag ctgggttaaa tccttatctc ctgagaaaac 2668741 cttaacttca aatccgtctt tttcagccga tttggccagt gtgccgataa tatcatccgc 2668801 ttcatattgt tccagttcat agcggctgat ctggtaggca tccagcagct cgcggataaa 2668861 cggcatttgt tcggaaagct caggcggggt tttctgtctg ccgcctttat attctttaaa 2668921 tgtgccgtga cgaaatgttg ttttcccggc atcaaacgca accagcatgt gcgtcggttt 2668981 ttcatcctca agcattttca tcaaaatcat cgcaaagccg tatacagcat tcgtatgaac 2669041 acctttatca ttgcttaaca gcggcaatgc aaaaaacgcc cggtaagcca gactgtttcc 2669101 gtctacaagc actaattttt ttcgttccgt cattcaattt cctcctaaga agcctcaggc 2669161 ttccattcat ctcttacata gtcattagct cctcttattt taacaaagtt caatttgaaa 2669221 ggaaaatacg tgaactataa gagaagacac aaaaaaggac gggaacacaa ataggttccc 2669281 gccgtcaaaa ttggctcctt ggatgaaggg gttctactac atcctaccag cataggttta 2669341 acagtgcatg aagatattgt taaacctttg taaacattag gcggactttt cagcggcccg 2669401 tttcagcgtc acggtaaaga cagttccccg tccaagctcg cttgtgacat caattttccc 2669461 ttcatgagcc tctattaaat gcttgacaat cgctaggccc agcccggttc cgcccgaatt 2669521 tctgcttctg tctttatcta cacggtaaaa gcgttcaaag atgcgcggaa tttcttcttt 2669581 ctgaattccg attccagaat cggcaacctc aatctgaatg tctttttctc tgggctttac 2669641 attgatagcc acggagcccc cctcaggcgt gtaggttaat gcattgttta cgagattaag 2669701 aaatacctgt ttcagcctgt acgggtcacc agatacatat tgagggtctt tcgggacatt 2669761 caggtgcaag gagatgcctt tctcatccgc cttatgcttc agaagcgttt caatctcacc 2669821 aagcattttg gccggctcaa acgtttcgat actgagcgtg aaattttgct gctcgatttt 2669881 tgagagatcg agcaaatcct gaaccaaaga ctgaagcctt tcgctttcct taagaataat 2669941 agagagaaat tcagaaagcg cctctttgtc ttccatcgcc ccgtccaata acgtctccgt 2670001 aaaccctttt atggacgtaa tcggtgtttt cagctcatga gaaacattgg ccacaaaatc 2670061 cttcctcatc tgctctaatt tcttcgtttc cgtcatgtca tggaaaacga gcacaattcc 2670121 tttccattca tcgtccggcc ccataatcgg aacgccgtcc acttcaaaat aacgccgttc 2670181 tattttgatc ggcagtctta acagcttgca tttctttgtc tccgtcataa aaatgtcttc 2670241 gacaagctgg atcacttctt catgttcaaa tgcatcgtga taaagacggc gcagcatatg 2670301 attcggattg atatgaaact gcttggcgta agacctgttt acgagattaa taaagcctct 2670361 tccgtcgatc ataatcagcc cggagccaat gttttcaatg actgtcagca gccgatcccg 2670421 ctgcatttcc tgcgttcgcg tcatttccat cagatcaatg gcaaggctgt tcatcgcatg 2670481 tcctagctta tcagaacgcc taatatagcc gccgtacgtc cgtgcatcgt agttgccctt 2670541 agagagttct gtggctacat ttgtcgctga ctcaattgac cttttataac gtgaggtcat 2670601 gctggaataa aaataaacaa tgacgataaa tgcggtacaa agactggccg tcagcatccc 2670661 ccacaattcg ccttttaagc cgtcgctttt ttcagaggcg gaaagcagca catatcctgt 2670721 tttttcacct tcgcttctaa gtgaaagtcc gtaataaagc ttgttatctg ttgttgacag 2670781 aataccctca tggccagaaa caagcgcctg caccttttgg gaatcagccg atctaccgtt 2670841 tgacccatac agcaccttac cgtctgtatc gataacggat gcgctcacat caagcgcgcc 2670901 gcctgcatct ttaatgattt tctcatttgc ttgattattc agattgccgg catcaagaag 2670961 cgaagccaag tattttgctt ctttttcaat gtgttcctct gctttccttt gatcagatgt 2671021 ttcaaaaagc tgctgtaaaa acagcccgag gacacaaaac accagaatca tacagacaac 2671081 gaatacagaa aaaaggcgca cacggtattt attcattcat ttttggctcc tccagtttat 2671141 accccaatcc cctaatcgtt ttaatgtaga tcggtttttt ggtattgttt tcaattttgt 2671201 cgcgaagatg gctgatgtgc acatcaacaa ttctcgtatc tccggcaaaa tcataattcc 2671261 agactgcgct cagcagcagg tctcttgtca gaactctgcc tttatgtctg cctaaataga 2671321 gcagcagttc gaattctttc ggtgtcagtt caagctgact ttctttaaag tacgcttcat 2671381 aatgatcagg caggattttc agatcgccga ttacgatctg gccttccatt tcatcgttct 2671441 tcatctcact agagggcgca gctatttccg aacgccttaa aatcgctttg actctcgcat 2671501 ttacttccct tggactgaac ggcttggtca tataatcatc agcaccgagc tccagcccta 2671561 atactttgtc gaattcctca tccttcgctg tcagcattaa aatgggaaac atcagttttt 2671621 gctgtctcag ctgcttgcat acttcgattc cgtccaattt tggaagcatc acatcaagca 2671681 caatcaaatc aggtttctct gtttccgctt ttttgagtgc ttcttcccca tccgaggcgg 2671741 taatgacatc atagcctgac cgttccaaat tgtactgtaa aagagtaaca atagattctt 2671801 catcatccac aactaaaatt ttcttgttca tgctgtgcct ccagtattat aattccccga 2671861 catcctattt ctctatttta tgtcatctta acatgtttca tgattttatt ttagcgaaag 2671921 caggacattc cgacaattcg ccttttacat catttttaaa agaaataaag acgtttatga 2671981 tagcgctttc atttatagta aaaagagaaa ggctgtatta agcaagcctt tctctctttt 2672041 tattaggata atactttcat gacatttttg acagattcaa ctgatttatt cagctgcgct 2672101 ctttcatagt ctgtcagttc aagttcaatg atttgctcaa gaccgttgcc gcctacaatt 2672161 gtaggaacac caaggtagat gccttcatag ccgtattccc cttcaagata agcaattgta 2672221 ggaaggacgc ggcgctgatc tttcaagatc gcttcgacca tttctgtcag agaagccgca 2672281 ggcgcataat acgcgcttcc gtttccaaga agattcacga tttcgcctcc gccttttcta 2672341 gtgcgctcca caattgcgtc aatccgttct ttcggaataa gagtttcaag cgggataccg 2672401 ccagcataag aataacgcac aagcggaacc atatcgtcac cgtgtccgcc gagtacgaaa 2672461 ccagtcacat ctttcactga caggtttaat tcctctgcca caaatgttct gaatcttgcc 2672521 gtatcaagca cacctgactg gccgattaca cgctctttag ggaagcctga ttctttgtac 2672581 accgcgtatg tcattgcatc aacaggattt gtcagcacca caataataga gtcaggagaa 2672641 tatttcacga tttcctgcgt aacgcttctc ataatctttt cgtttgtaga gaccagatca 2672701 tctctgctca taccaggttt tcttgcgata ccggctgtaa tgacaacaat gtcagagccg 2672761 gctgtatcct cgtaattgga tgttcccgta atttttgcgt caaagccttg aaccgggctt 2672821 gcttcaagca tatcaagcgc ttttcccttt gtcgggttct ccaattgcgg aatgtcaaca 2672881 agaacaacgt ctgccagctc tttttgagcg attaaaaatg cagttgtagc tccggtaaaa 2672941 cctgctccga taacagaaac ttttttacga gtatttccca tgtctctctt ctcctttatg 2673001 gctagtttta ggctttttcc ttgcttagtc catgtttttg atcagttctt ctccgaactc 2673061 tgaacatttc acttcagtcg ccccgtccat taatctggca aaatcgtaag ttacgacttt 2673121 agaagcgatt gttttttcca tagatttgat aaccaaatca gccgcttcgt tccatcctaa 2673181 atgctcaaga agcagaacgc ctgaaagaat aactgaagat gggtttactt tatcaaggcc 2673241 tgcatattta ggagccgttc cgtgcgtcgc ctcgaaaatc gcatgtcctg tttcgtagtt 2673301 gatgttcgct ccaggagcaa tgccgattcc gccgacttgc gcagcaagag catcagaaat 2673361 gtaatctccg ttcaagttca ttgtcgcaac gacatcaaac tcgtttggac gcgttaagat 2673421 ctgctgaagg aaaatgtcag caatgctgtc tttgataatg atttttcctg ctgcttccgc 2673481 ttcgctttgc gctttgttgg cagcgtcttt tccttgttct tcagcaatgc ggtcatattg 2673541 agcccatgtg aagactttat ctccgtattc tttttcagca agttcatagc cccagttttt 2673601 gaaggcgcct tctgtgaact tcatgatgtt tcctttgtga acaagtgtta cagatttgcg 2673661 gccatgctcg atcgcataat caatggcagc tctgaccaag cggcttgttc cttcttctga 2673721 aacaggctta atgccgatac ctgatgtctc agggaaacgg attttattga cgtttaactc 2673781 attttgaagg aagctgataa gcttttgcac ttcttcagag ccttttgcat actcgatgcc 2673841 tgcgtaaata tcttctgtat tttcacggaa gatgaccata tcagtatctt cagggcgttt 2673901 taccggtgac ggcactccag taaagtatct tacaggtctt aagcagacga ataggtcaag 2673961 ctcttgtctg agcgctacgt tcaaagaacg gataccgccg ccgacaggtg tcgttaacgg 2674021 gcctttaatc gcgatgaaat attcgcggat cacatctaat gtttcagcag ggagccactc 2674081 acctgtttta ttataagcct tttctccggc gtaaacttct ttccatgtaa ttttcttttc 2674141 gcctttgtat gctttttcta ctgctgcttc caaaaccttc gaagccgcgt tccaaatatc 2674201 aggaccggtt ccgtctcctt cgataaatgg gataatcggg ttgtttggta cgtttaatac 2674261 tccgttagag actgtaattt tttcaccttg tgccacaata aaaacctccc agtatgtaat 2674321 tcatatttag aaaacatttt atttttctta tatagaaaat aaaatgattt ttcctaacat 2674381 tcaatttaaa gtgtaaccca attttgatgt ctgaacaaga ggctaacctc attgacgcaa 2674441 gccagcctcc aatggttctt taggctcttt cttcaatcgg aacgaatttt tgtttgtcag 2674501 ggcctgtgta atctgcccgc gggcggatca gacggttgtt gtcatactgc tcaagaatat 2674561 gagcgagcca gccggacatt ctgcttacag caaaaatcgg tgtaaacaaa tcatggtcaa 2674621 taccgaggct gtgatataca gaagccgaat agaaatcaac gttaggcgga agctttttct 2674681 ctgatgtgac gatgtcttct atacgaatcg acatctcata ccatttgctt tcgcctgtca 2674741 ggttggtcag gcgcttgctc atttctttca gatgcttcgc gcgcggatca ccatgcttat 2674801 acacacggtg gccgaatccc atgatttttt ctttcttttc aagtttagcg cggatgtacg 2674861 gctcagcgtt ttccacttca ccgatttctg tcagcatttt cataacgcct tcattcgctc 2674921 cgccgtgaag aggccctttc agcgcgccga ttgctgcagt aatgcctgaa tagatgtcag 2674981 aaagtgttgc gacgcagacc ctcgctgtga acgttgacgc gttcagctca tggtcagcat 2675041 gtaaaatcaa tgctttgttg aaggcttcaa cttcaattgg tgaaggctct tcaccgttta 2675101 atgtgtaaag aaaattctcc gcaataccgt aatcttctct cggttcaaca ggctcaagac 2675161 ccttgcgaat tctggaaaac gctgcaacca ggccaggcac ctttgcctga aggcggatcg 2675221 cctttctgta gttggcttcc gggttcatgg tatcagcctc gctgtcaagc aggcctagta 2675281 atgaaattgc tgtccgaaga gcagccatgg gatgaacatt ttcgagggaa taagatttga 2675341 agtgctcaat aatttcttgc ggaacggcag cttcctttgc aagctgctgc tttaactctt 2675401 caagctcttt tttgtttggc agccttagat gccaaagcaa gtagatgatt tcttcaaaac 2675461 ttgcattctc tgtcaaatca tcgatatcat accccacata tgtaagggta tcatcaataa 2675521 tagaactaac agatgatgtt gttgctacaa ccccttcaag accgcgtgtc gctgtcatat 2675581 ataacatctc cttttcaata aatttcccct ttaagagtgt tgtaaaaaca tgaggcttac 2675641 ttaaaaagca cgatgcaagt atttctctcc cccaaaaaga aaatgcttac attttactgg 2675701 ctgctggaac taaaaccctt tgcttttgaa agaacataac aaatttttat aagcttattt 2675761 aagtttaagc ctattctcat tataaacaat aatcagacat ttgttaaatg tttacctata 2675821 attttttttt tccattctgt gatttccccg aaaaaacgcc tttatttgcg ggtttttgca 2675881 taaaaaaaag cggctttaag gccgcttttt tttatgaagt gaacagtttt acgatctgca 2675941 tggctaaata agcaatcccc gctccgatca gcggccccac cgcaactcct ccaaaaagcg 2676001 cgactgcaag aatggtcccg atcacgagag cagttgtaat atgcggatca ttttcaagca 2676061 gggtcaggcc gttttttgca atcagcgcca ctgcgatccc cgctccaagg gcgatccatg 2676121 cgtaggaaga ccgcattgct tctccaagct gcttaaatcc gatttctccc gtggcaatcg 2676181 ggacaagaac ggcgatggta ataatggtca caccccagtt aatgcctttt gactggatgg 2676241 tcggaaataa tttctgatca agcccaacga ttttgatgat caaaaggacg gatacagcaa 2676301 agagcaatga ttggtttttt gcgataagtg cgatagccaa gagtaaaatt aaaaataaat 2676361 tcgcttgtgt aaacacatgc catccctcct ttaagatgaa tgtattcata ttcagccgca 2676421 gcgtgaatac atataaaaaa taggacatgc tgacgagagg aggaccgttt ttgtgaatca 2676481 atcttatatc actatttttt tcagaaccct ctttgtcata tcaatgaccg cagggtcgat 2676541 agctgcggcc tattattcgt ttccgttaac ttatccgttc ctgatcgccc ttattctatc 2676601 ttcagtgatt catcctgttg tcgattattt ggacaaagtg acaggattcc cccgaacgat 2676661 aaatgttctg ggcgttcttg ctttttttct gctcgcagcc ttcggcgtgc tcaccattct 2676721 ggtagccgaa atcgtaacgg gaacagccta tctagcaaaa acgctgcctc cgcatatcag 2676781 cacgtttatt tcatattgcg aaaaattgtt taccactcat attcagccgc tctataacga 2676841 gttaactctt ttgtttcaag aattggaaac gaaccagcag gcttccatcg tcactcatat 2676901 ccagacactc ggtgattctg ccgctaaaaa tgccgggctc ctgctgtccc acattctaga 2676961 gatgatcccg agatttttcg ctcttcttcc caatacggcg gcggttctga ttttttctct 2677021 tctggcaacc ttttttatga caaaggattg gcataagctg aaagccatgc ttgttttaat 2677081 tctgccggat cgtgtgacag ctaacagcaa agcaatcagc agcgaattaa aaaaagcaat 2677141 gactggtttt atcaaagcac aagccgtcct cgttttcatc acgatggtga ttgtatttat 2677201 cggcctttct ctcttaaagg ttgaacacgc cgcaacaatt gcttttttaa tcgggcttgt 2677261 agatcttctc ccttacttag gtgccggctc cgtatttgtg ccctggattt tgtatttatc 2677321 gattacgggc cagctgcccc aagcaatcgg aattggtatc ctgtacctcg tcgttcttat 2677381 tcagcggcag ctgacagagc ccaagatact aagtaaatct atcgggatcg atccgctggc 2677441 aacactcatc gccctgtttg ccggctttaa attattcggg tttttaggac tgattgcggg 2677501 accggctgta ctcgtcatca tccaagcttt catcacaaca ggcgcattaa aagaaatatg 2677561 gtcctatatc accgttcagc aaaaataaaa cggcagccgt tttttcatgg ctgccgtttt 2677621 ttatttgatg atgatccgct tattcttcga cattcctctc agccatttga acagaatcgg 2677681 cttacaccag ccgcgggtaa acgggataag aagacaggcg ccggccaaat ctgataaaaa 2677741 gcccggaagc atcagcaata gaccgccaat gaaaatgcac agaccgtcag caatcgcttc 2677801 tcccggcatt ttgccatatt gaagatcacg ctgaacctta taatacactt cggttccttg 2677861 tttttttgca gctgctgcgc cgataatgcc agtcagaatc atgaatagaa ctgtcggcaa 2677921 aataccaatc agatttccta aaaataggaa tataccgatt tctattgccg gaaacacaat 2677981 aaaaagcaaa aacaaaaatc tcatatccaa gccccccaca cgtgtaacac gttctgttca 2678041 acaaaaggca tgataaagag aaaaggaagg gattcccctt ccattttcac ctgtaattaa 2678101 agaacgctcg cacggccttg atagactgcg cctctggaag cgtcaactgt aatatcctgg 2678161 ccatctgtca aaatagatgt cgcattttcc agacccacga taaccgggat gccaaggctt 2678221 aatccgacta ccgcagcatg gctagtcaaa ccgccttctt ctgtaataag agcagacgct 2678281 ttttcaaggg atgcaatcat atcacggtca gtgcttttgg taacaagtac cgcaccgtca 2678341 gtcatttttt gctcagcttc ttttgcattt tgtgcaacga caaccggacc gtaagctgat 2678401 ttgcgtccaa tgccttggcc tttagcgatg atatcgccga cagtatgaac cttcattaag 2678461 ttcgtagtgc cggactcacc gacagtgcca gctgtaataa cgataagatc gccgtgtttt 2678521 acaattccgc tgttcaatga tttttggaca gcatcctcaa gcatctcatc tgttgagctc 2678581 gcattttggc cgctttccgc gaatacgcca gatacgaggg caagctttct ggaaatagag 2678641 tcatttacag taaccgcaac aatcggagcc tgcggacggt attttgcaat catacgtgct 2678701 gtatggccgc tttctgtcgg cgttacgatc gcagcagcat tcaggttaat cgccgtatgt 2678761 gcgacagatt gtccaattgc gtctgtaatt gtcatgccca cttggtctct gcgttttgag 2678821 agaatttctt tataatttaa tgcttcttca gaacgggacg cgatgttatg cattgtttga 2678881 actgcttcaa ccgggtaact tccggcagca gtttcaccag aaagcatgat cgcatctgtt 2678941 ccgtcgaaga tcgcgtttgc aacgtcactt gcttccgcac gagtcggacg cgggttgcgc 2679001 tgcatgctgt caagcatttg tgtcgctgta ataacaggtt tgcccagcgc gttgcatttt 2679061 ttgatcagtt ctttttgcac aagcggcact tcttcagctg gaatttccac acctaagtct 2679121 ccgcgtgcaa ccattaagcc gtcagacact tcgagaatcg catcgatgtt gtcaacgccc 2679181 tcttggtttt cgattttagg gatgatttga atatcctgag cgttgtgctc ttcaagaagc 2679241 tcacggattt cgagcacatc cgtagaacgt cgaatgaaag atggtgcgat gaagtctact 2679301 ccttgctcaa taccgaaaac gatgtctcgc gcatcctttt cagtaatccc cggaagattg 2679361 acacttacgc ccggtacgtt aacacctttt ttatttttga gtgttccgtt gtttaatact 2679421 tttgttttga tttcgcgttt agcggcatct acatcaagta cctcaagacc gataaggccg 2679481 tcatctaaca gaatcgttga accttgttca acgtcatgga ctaaaccttc atatgtcact 2679541 gaaattttat ctgttgttcc tacaacctcg tccattgaaa taatgagctc tttgcctgtt 2679601 tcaagctcaa taccgccgtt ttccattgta tgtgtgcgga tttcaggacc ttttgtatca 2679661 agcagaattc caacgttctt gccaagtttt ttacttgctt cgcggatatt tttaattctt 2679721 gcaccgtgct cctcaaaatc tccgtgagaa aagtttaatc gagccacgtt cattcctgac 2679781 tccattaatt tcgtaagcat ttcaatactt tcacttgccg gaccgatggt acaaacaatt 2679841 ttagtttttc tcatttggtt cacttccttc tgaaatcttc agccttcagc tgtacattag 2679901 atagacagtt cttttgaaag ctgatacatg ttttgctcaa ctgtgtgttt tgtctcaagt 2679961 atttctataa tatcatggtc tacaagctta ttgttttgta tacctacaca gcgtccgcct 2680021 tttccttcaa gcagcagttc aactgcatat gcgccgagac ggcttgccaa cacacggtca 2680081 gcagcactcg gagaacctcc gcgctggata tggcccaata cagataccct agtttcaaga 2680141 tttgtttctt cttcaatgcg tttcccgaat tcaacaccgc tgcctacacc ttcggcaaca 2680201 ataataatac tgtgcttctt gccgcgttcg tggccgcgtt ttaagcgggc aatgatttcg 2680261 tgcatgtcat agtctgcctc agggattaag atcgattctg cgccccctgc aagaccggcc 2680321 cacaatgcga tatcgccggc atgacggccc attacttcga ttacatatgt acgttcatga 2680381 gaagtcgctg tatcgcgaat cttatcaatt gcgtcaatta ctgtatttaa agctgtatcg 2680441 aaaccgattg taaaatcagt gcccggaatg tcattatcaa ttgtacccgg tacacctaca 2680501 catggaaacc cgtgttccgt taattttttc gcacccatat aggaaccgtc tccaccgata 2680561 acaacaaggc cttcaatacc aagcttcttc aagtttgcta tccctttttc acggccttca 2680621 actgttttga attcaggaca tctcgccgta taaagcttag tccctccacg atgtataata 2680681 tcgcctactg atccgagttc aagcttttca atctttccgc tgatcaatcc cgcgtatccg 2680741 ttgtaaatac cgtaaacttc aacgtcatga tagatcgctt ttctgactac tgcgcgaact 2680801 gctgcgttca ttcccgggga atccccgccg ctcgttaata cccctattcg tttcattctc 2680861 cattcacctc agcaacatat atgattaaac ataacatgat cattgcccta aaaacaatga 2680921 aaagggatct ccatcctccc tatgaaacct tacctattat acaattaaat aaattgtttt 2680981 taaataaaat ttaaggaatg tcacaaaaaa taaacgtgag ccaaaggctt cacgtttatt 2681041 tagtttaccc cgatatattg atcttcaacc gagactttgc caattgcttt atatttttca 2681101 taacgctgct gaactaattc ttcttcgctc agcttcagta aagtttttaa cgattgttta 2681161 agggtttcgt ccatatagct tgcctgcagc ttcacatcat ggtgcgctcc gccttttact 2681221 tctttaatca tatgatctat aatacctaat tcttttaaat ccggcgcagt gattttcatt 2681281 gtttctgctg cttttttagc aagactggag tccttccata aaagtgccgc ggcaccttcc 2681341 ggagaaataa cagaataagt agagttttcc agcatatgca agtgattgcc tacacccaga 2681401 ccaagggctc cgccgcttcc gccttcacca atgacgatgc agataacagg cactcgaagg 2681461 ccggccatct caaacaggtt tttggcaata gcttcacttt gtcctctttc ttcagctgct 2681521 cgtccagggt atgccccctt cgtatcaata aaacagataa ttggtctgtt aaatttgtca 2681581 gcctgtttca tcagacgaag cgcttttctg tagccttctg gatgcggcat cccaaaattg 2681641 cggactaggt tttccttcgt gtctttgccg cgctgatgcc cgattaccgt tacagggagg 2681701 ccgtggaact tcgcaatccc gccgacaatg gcttcatcgt ccccgtacgc tctgtctccg 2681761 tgacattcaa aaaagtcggt aaacaggtgt tcgatataat caagagttgt cggacggtcc 2681821 gccagacgcg cgatttgaac ccggtcccac ggcttcaaat ttttgtaaat atcatcctga 2681881 agcttagcga gacggtcttc gagccgttcg atttccgcac ttagatccat atcggaatct 2681941 tgggtgaatt tttttagttc ggcgattttg gtttgcagtt caatcaccgg tttttcaaat 2682001 tctaatcttg gagccactca atgtcacctc ctgtttgatg catatccagc agattttcta 2682061 acgttttttt catatcgtcg cgatgaataa ccgcatcaag ctgtccatgt tttaataaaa 2682121 actcagccgt ttggaagtcc tcaggcagtt tttctcctat tgtctgttca ataatccgtc 2682181 ttccggcaaa accgatcagc gcgccaggct cagcgaaatt gtaatcgcca agggatgcaa 2682241 agcttgctga tacgcccccg gtagtcggat gcgtcattac tgaaataata agaccctgtt 2682301 cttcactgaa cagttttaac gcagagcttg tctttgccat ctgcatcaaa cttaatacgc 2682361 cttcctgcat tctagcaccg cctgaagccg taaaaataat aaacggaact ttatcagctt 2682421 ttgctttttc aatcgcaagc gtgatttttt caccgacgac tgaacccatg ctgcccattc 2682481 tgaatgaaga gtccatgacg gcgacaacag ccgggtgtcc gccgatggtg cccttgcctg 2682541 tcacaacagc ctcgtttaag gatgttttct cgcgatcttt ttcaagcttt tccagatatc 2682601 ccgggaaacc aagcggattt tccgagagca ttccctgatt aaattcctca aaggattgtt 2682661 catccatcaa gctttcgata cgctgttttg cgttcattgg gaaatgataa tcgcagttca 2682721 tgcatacccg catattttta tccaactctt tagtgagcat gattttttta cacttaggac 2682781 attttgtcat aatgccttcc ggaacatcgt gcttcgcttg atcagacggt acggaagcat 2682841 actttttctt tttcgtgaat atatccttta acaaatgatt acctcccttt tgtgaagggt 2682901 tctcttcacc gcatgtcatc aaacagatag acttgctaat aactttaccg aaactattgt 2682961 actttttttg tcaaacgctg tcatcctcaa ttcgacaact ttttattcga tgacgtgctc 2683021 ggaaaggctt gtatgaaatc agataaggtg ttgaaacgac aaggttgaca gcgcattcaa 2683081 aaataatgtt aaacccggct gaaatttttt taaggctaac cccctaaaaa aatttcagcc 2683141 gtcagtttaa cttgagaaca gcgcgccggt ctccgccaac gcgctgccat ttttggaatg 2683201 aattaaaatt attcaccaat aatcgtaagt tttcttgttt tttctgcgac ttcctcaggg 2683261 tcaacagtga ttcttgcaac acctgtttcc atcgcagctt ttgccacagc cttcgcaaca 2683321 gcaggcgcaa cacgtttatc aaacggtgca gggatgacat agtctgcgct aagctcatct 2683381 tctgaaacca gtgaagcaat ggcttcaacc gctgcgattt tcatttcctc gttaatatga 2683441 gtggcacgca catcaagcgc tccgcggaaa ataccaggga atgcaagaac attgtttact 2683501 tggttcggga agtcagaacg gccagttccg acaacgcttg ctccggcttc acgcgcatct 2683561 tccggcatga tttccggatt tggatttgcc attgcaaaga taatcggatc ttttgccatg 2683621 ctttgaacca tttcttttgt taacgcgcct gctacagaga caccgataaa tacgtcagca 2683681 tcaacgataa catctttcag agaaccgtct ttgcgatctt ggttcgtgaa cttcgccact 2683741 tcatttttga catcgttcat gccgttcggg cgcccttcat aaatggcccc tttggaatcg 2683801 cacatcacaa tgtcgcgaac gccataatga tgaagaagct tgataatcgc aatgccagcc 2683861 gcacccgcgc cgtttgcgac aactttaatg gatgacatgg attttccaga cagtttcagc 2683921 gcgttcacaa gacctgctac ggttacaatg gcagtaccgt gctgatcatc atggaaaacc 2683981 gggatgtttg tttctttttt gaggcgctct tcaatgataa agcagtttgg cgctgcaata 2684041 tcttcaaggt tgacgccgcc aaatgtcggt tccagcaatt ttacagtttc aacgatttta 2684101 tcaacatcgt ttgtgtttaa agcaatcggg aacgcatcta cgcccgcaaa gcttttgaaa 2684161 agaactgctt tcccttccat aacaggaagc gccgcttcag ggccgatgtt tccaaggcca 2684221 agcacagctg taccgtcagt tacaactgct accatgttcc ccttcattgt ataatcatat 2684281 actttgttaa tgtcttcatg aatatcctta cacggttctg caacacccgg agaatacgcg 2684341 aggcttaaat ctttcgcatt tctgacctct acttttgatt tagactccag tttcccctgg 2684401 ttgactttat gcaggtgtaa tgcttcttct cttaatgaca ttctcctaaa cactccttat 2684461 ggatattttt tgattcgtat actgctgcgt tgattgctgc attctgcgga gtaaatctat 2684521 ctgaatattt aaacaggatc acataattgc tccaattgta taacaaaaag cgaatcgtta 2684581 ccactgtttt aaaacgacgt ttttttgacc caacagctct tttaagcgat ataacacctg 2684641 gtgatctgca ttgatatgga acgactcagg tagcttaatc gtctgttttt gcctttcata 2684701 atagagataa acgcctgttt cccctttatg ctccagcaaa atgcgcttaa tctttgccag 2684761 gatctcctgg ctgtgctgac tgctttctat ttttatataa accgatggcg ctttttctgc 2684821 atccatatct tctaataatt ctgcccggga catgatgaat tggatcttat cttgtctaac 2684881 ttcacatttc cccgcagtga acaaaagagc gccttctctt aaaacgggag aaagctgtct 2684941 gaattgttca gggaagacta cggcttccat ctcgccggtt tcatcactga gcgttaaaaa 2685001 cgccatgttt tgacctgttt tcgtccgaat cgttttgatc ttcgacagca gaacgcctag 2685061 tgaaagctgc cttttgactg cccgctgagc ctgcagaatg gagactgctc cttgcgcagt 2685121 gagctgtttt cggaaggcgg agaggggatg atttgaaaaa taaatgccaa gcgtttcctt 2685181 ttcaaacgca agtaaatcca ccagaggaag ctcctccgtc tccacatact tcggcttaat 2685241 tgaaaacgat tcatctaaaa acaatcccat ttggtcatcg tccgcggcga atagctcagc 2685301 atgttccaaa gcaacatcaa tggatgcgag cagcgtggcc cggttttggc cgaattcgtc 2685361 catcgcacca gaaaagataa gtgcttcaag cattttgcga tttacgcttt ttgacggcac 2685421 gcgaaagcag aaatcgaaaa gatcttcaaa tggtttctct tttcttgctt tatatatatc 2685481 tttgactgct gagacgccta cactttttat cgcgcggagg ctgtatctga cagatccgtt 2685541 ttcaactgta aacggaaaac tgcttttatt cactgacgga ggaaggatac gaatcccgct 2685601 cccctttgct tcgtaaagat attgagagat tttatcctca ttgccaatga cgcttgtcag 2685661 caatccgcac ataaaatata acggataatg agctttcaaa tacgcaagct ggcacccgat 2685721 catgctgtat gccaccgcat ggcttctgtt aaagccatag tttgcgaatt tgacgattaa 2685781 atcgtagacc tcatttgcag tgtctacaga atactccttt tttaagcacc cttcaacaaa 2685841 atggcttcgc tctctgtcca ggatttcttt tttctttttg ctgaccgccc ttctcaatag 2685901 gtccgcttcg cctaaagaaa accccgccat acgggaagca atcatcataa tttgttcctg 2685961 atacacaatg acgccatatg tatcttccaa aatgctcctt aaatcttcat gaggatagtg 2686021 aacaggcgcc cgaccgtgtt tacggtcgat aaataacgga atattttcca tcggacccgg 2686081 ccggtacagt gcattgaccg ccacaatatc ttctaggccc gaaggtttca gccgtttcaa 2686141 gacgcttctc atccctgcag attcaagctg gaaaatgcct gtcgtatccc cttttgacag 2686201 caaggagaac gttttgtcat cgctgtagga aatacttgaa aggtctattt taatattttc 2686261 ttctttttca atcattgaag tgatggattc aataagtgtc agattcctca aacctaagaa 2686321 atccattttt aaaaggccca agtcttcaag atggtccatc gcgtattgcg ttaaatagat 2686381 cccttcatgc ccttcttgaa gcggaacaac atctgttaac ggttcttcac tcaggacaac 2686441 gcccgctgcg tgggttgatg catgccttgg cagcccttct attttccggg caattgaata 2686501 gacttgctga agcaggcttg actcccgaag ccgcttatcc agctgcggtg actgctgtct 2686561 cgcttcatcc agcgtcattc ccggtcttga aggaatgagt tttgcaagct gatctgcctc 2686621 cttcgggctg acgccgaata ctctgccgac gtcccggagc gccgcctttg ccgcaagtgt 2686681 tccaaaggtg ataatctgtg cgacgtgcat tgcaccgtat ttctgctgaa catattgaat 2686741 gacttcatcc cttctagtat cgggaaagtc aatatcaata tccggcatgc tgacgcgttc 2686801 gggatttaaa aatctttcaa acagaaggtg atgcttaatc gggtcaacat ctgtgatata 2686861 cagcacatat gccacaagag aacccgccgc agaacccctt cccggtcctg taacaatccc 2686921 tttttcatgg gcgtgcttca taaaatccca cacgatcaga aagtaatcgc tgaacttcat 2686981 ccgcttgatg acatcaagct catattgaag acggcgaagg tatcgttcat caggcttgcc 2687041 gaaacggctg cggagtccct ccatacagat atccgttaaa taatcatcag cggacgttcc 2687101 gtctggggtc ggaaaagacg gtagacgggt ctgcccgaga ctgacgtcaa cccggcattg 2687161 ttccgcgatc tctacagaag cttgcagtgc ctcgggatgc tctcgataaa tgttttgcat 2687221 ttcttcgagt ggtttcaaat cgagatcagg caaatcttca gcgggtgcat ccgtcagttt 2687281 ttcccccgct ttaatcgctt tcaaacaacg gtaggcagcc ttatcttcct tccttatgta 2687341 atgcacatcg cctgtggccg taacagggat acccgtttct tctgacagct ttagaatctg 2687401 ctcagacaag acttgattcc ctttaaaagg ctgataggag aaataaaaag ctccctttcc 2687461 gaatatagac tgaaattcca gcgaggcttg agcagcctgt tcgaacagcc ctccttcaag 2687521 aagcgtttca atatatcctt tttcgccggg cgttattgcg ataatccctt ctcgataact 2687581 gtgaagccat ttcggcttca gtccgccttt tgatttagat tgcagaacgc tgctgatttt 2687641 cagcaggttt tgatagcctg tattcgattt tgccagcagg acgagcgggt atgcttcaag 2687701 ctcgctgtca tctgtaaaaa cagaagccgt caaaccgatt attgggttga tccctctcgc 2687761 cttgcaagct ttataaaatt gaatagctcc gtacatgaca tgatcatctg tcagcgccaa 2687821 agacgcatat ccgagcctgt cagcttcact gacgagttct tccacagccg cggcgctgtt 2687881 tagcaggcta tacccgctat gcacttgcag gtgaacaaaa gacatgctat cacctctttc 2687941 tcattacgat ccatttcttc cttcattata aggccggttt ccaaaagaaa caaatgttct 2688001 tttttgactc atcatcatac ttgtcctgaa agctcaatat gatataaaag gtgaggtgat 2688061 aaagatggat caggaagcag gatttatggt gaattttatc aatagctact tcattgcgtt 2688121 aggggtgctg atcgggggcg cactcatcgg agggctcgga gcatacttgg caggcgaacc 2688181 cccgcttaca gccattacaa agcttgccaa ccggttaaaa atatgggcgc ttgtcgcagc 2688241 tatcggaggc acctttgatg cggtatacag ctttgaacgc ggcatactcg aaggcaatac 2688301 gagagatatc tttaaacagc ttcttttaat tatttcggcc atggggggcg cgcaaagcgg 2688361 ctggcttatt atatcatggc tgacccagga gcatctttct tcatgagggt cccccagcat 2688421 tacaaaaaac cgggatggca gcgttttttc gcgggaatga tgtgcggagc cgtaatcagc 2688481 tggttctttt tcctgtttac ttacggaaca ttccaagagg agcaggtcag cctcatcgaa 2688541 aagcaaaaag agcatgtaaa agacttgaac aatcaaattt cgatctatca ggaagacctc 2688601 cataaactga atgaagataa taaaagaaaa ctgctgattc aaagcgtcag cgtcaaattg 2688661 ctgaatgggg ataaatataa aatatcacag ccggataaaa cgaaattcga ggagcatgta 2688721 aaggatgata tttcagaggt gattacaaaa gacatagaga gcgtctatca aacaaaggat 2688781 ctcttgaagc ggacaattga aaataaagtc tatatgatca atgaaaaaaa atacgaggca 2688841 accgtcagag aattgattat ttatacgagg ctgacagtgg aacttgaaat ttctttcgcc 2688901 acataattat ggattttttt taaattctcc aaacttctgt cgctttttcc cattcttttt 2688961 tataaactat atgtgaggct taatggcgaa aggaaggagg aagggaaatg gaggtttaca 2689021 gtgaccgtca gttagcaaaa gatcaagcag cccgtctcag acaaggtttt tctgcatatg 2689081 ccgaaacaaa ctcactcgct tccctcatca aaaaagaact tcaatcacac aatctccaag 2689141 tctacgagga ccttactgat ttcggctgct ggttcatccc cgtcacagat gaacactaag 2689201 agagagggtc tcccctctac tcgtgttctt tacataatgt ttccagatca gctaaaatac 2689261 gatcagcttc atcccagctg taaatagagg cgcctgaagc taacggatgc cctccgccgt 2689321 tatatttccg ggcaagtccg ttaatgacag gccccttcga acggaatctg actctgattt 2689381 gatcgtcttc ttctacgaaa aacacccagg cgcgaatacc tgagatattg ccaagcgtcc 2689441 cgacaagctg cgacgcttca gaagccgttg tgccgaattt ttcaagcgta tcctttttga 2689501 tgaaaacaga agccgccccg ttttcggaca aagacacatt ttgaaagata aagccgttaa 2689561 gcttcaccac attcagtttt gtttcataca attgattaaa taactctgag gaagagaatg 2689621 gatactgaat gagctcgcct gcatatttta gtgttttttc cgtggtattc ggaaataaaa 2689681 agcgtccggt atctccaaca atgccggcgt agatcagctc tgccgctttc gtattcagct 2689741 tccagccgtg ctcttttcct tctaaataca gctcgtaaat catttcactt actgagctgg 2689801 cgcttgtatc gacccagaga aggtcaccgt atggatcttc gttcggatgg tggtcgattt 2689861 tcattagttt ggcgcctgaa ggataacgct gatcgtcgat tctttcctga tttgccgtat 2689921 cgcagacaat gacaagtgcg ccttcatatg tttcattgtc cacctcatca agggaatata 2689981 agaaagagag ggacggttca ggcgtgccga ccgcaaaaat atttttttca ggatatgttt 2690041 cacgcaggat ttccgtaagc ccacactgtg atccgtaggc atccggatca ggacgcacat 2690101 gtctatgtaa gataatcgtg tcatataatg atatggttct gatcaattct gttttcattt 2690161 gatactcctt tattgttttt attcattaaa tcacattctc tgccgacgga aaagaaaaat 2690221 aacgtcaaaa ccaagcccgt ttttgtataa aatggggttg taaactttta cgatggagga 2690281 tttcatttat gctggttctt gtttttttga ttgggctttc agcctgcttt tatgtgtact 2690341 ataaagtaaa aggcgtacgg gcaaagccat ctttggcaaa agaaatatgt tcagcaaaat 2690401 caagcatggc cttagggtca ctagtcctgt tctacgggct taaccaaatg atattattcc 2690461 attcagtatt aacgttagta atcggcggta tctttatcgt cataggagca ggaagcgctt 2690521 gggcaggtta taaagccttc aggcattaca atccccttca cgccaaagaa gctgaaagag 2690581 atcacgcgta aggggcgcct gaacgtccct tagcttcttt ccatcagctg aaccatcagc 2690641 atcgctttag acacgatatg accttggctg tgcacttcca cttccatttt cccaaacttt 2690701 ctgccggcct ccaagatgcg aggtttgact tcgatgactg attccatctg cacaggcttc 2690761 aaaaagaaga tggtgatgct ctctatgacg agttcgccgc gttttttcga gcgcaaaaat 2690821 cggtttgccg cttgcgtcaa aatggtcgta aatacgccat aagaaatggt tccaagctga 2690881 tttgtcattt gcggcgtgac ttcatactcg taaaccgttt gatcttcttt atcatcaccc 2690941 tcatctttaa acccccttga aacgatatca tcaagcttct ccccgacctg cggctgcttt 2691001 tgaatcattt gaagagcttt caatacgtct tggcggctga tcatgccgat gagtttttgg 2691061 tggccgtcag tgacgggaag cacttcgatc ccttcccata ccatcatttg cgcagctgaa 2691121 gcgacagatg ttttcccaat aaccgtgacg ggatttttgg tcatgacttt ttctatagat 2691181 gcatttcggt catggccagc aatatctttt gatgtcagaa tgccatggat tttcatttga 2691241 tcgtcgacaa ccgggaagcg gccgtgcccc gtttcaaaat ttttctcata ccatttttca 2691301 agtttatcct taggcgaaag atataccgtg cggtcagcag gtgttaggat gtcctccacc 2691361 aaaacaattt cttttttgat cagctggtca tatattgccc ggttaatcat cgcggcaact 2691421 gtaaaggtgt catagctcgt ggataaaatc ggcagttcaa gctcatctgc cagctgcaca 2691481 atgctgtcat ccgtgttaaa gcccccggtc accaatacgg ccgcgcccgc ttcaagcgcc 2691541 tgcctgtgtg cattgattct gtttccgaca atcaaaagat tccccgctgc ggtgtaacgc 2691601 atcatcgcgt caagctccat cgcgccgatg acgaatttat tcaatgtctt atggagccct 2691661 gccctgcctc cgagcacttg tccgtctata acatttacaa cctctgcata ggtaagcttt 2691721 tcaatgttct cttttttctt ttgttcaatt ctgattgtgc ccacacgttc aatcgtgctg 2691781 acaaaccctt tattctctgc ttccttgatc gctctgtacg cggttccttc gcttactttc 2691841 atttcctttg caattcttcg gacagaaatt ttttcaccga caggcagtga atcgatatac 2691901 gttaaaattt gttcatgctt cgttgccaag cctttcacct ctaaggacag tcttcttgtt 2691961 tttattataa ggtttcaaag gatttatacg caatgaggct ggaaaataaa aaagaagccc 2692021 gaccggcttc ttacagcgtt gatttcgttc cagtcaaacg caaggaccac gtgattcctt 2692081 ttacatcgta aagcggaaaa acctttattt ttcttttaaa tggacatcaa ccgctgtctt 2692141 aacaatattt cgattcccta ttttagataa aacaaataaa actgcggata gccatatcgc 2692201 ccctatggcc gtatagatca atggatgaac agctgtgttt gcgatccatt catttattaa 2692261 tgttctggca tttaccagaa taataaatcc tcctacaagc acacccatca attgcggatg 2692321 aaacttctgc accagccatg ctgcgatagg ggcagcgata attccgccgg ccattagtga 2692381 aaacacccat aaccaattga cgtcctccca tcctaatgaa ataagaaaac cggcggttgc 2692441 agatacggcg atggcaaatt cacttgtgtc tacagtcccg acaactttcc tcgggctcaa 2692501 gcctttgcgg gataataaaa tcggagtggt caccggtccc cagccgcctc cgcctgtggc 2692561 atctgcaaaa ccagcgatca ctcccaatgg gatggattgt tttcggttta acggcacatg 2692621 cttcttctca agagccggct tatattgaaa taaaaacctg atcaatacat atccgcccag 2692681 aaggagcaaa aacaaagaaa tatagggttt cgccacatct ccaggtaatt ggctgaggaa 2692741 tgccgcgcct aaaaaagcgc ctatagagcc gggaatgaca agctgataaa cggtttgttt 2692801 gtcaacattg ccaaatttaa tatgcgacac tcccgatgcg gcagtcgtta cgacttccgc 2692861 taaatggaca gaagccgaag ccacagcagg tgtgatgcca aacgccaata acaaagaagt 2692921 tgaggtaacc ccataagcca tacctaacga accgtctatt aactgcgaca ataaaccaat 2692981 aaatgcaaaa acgattaatt tcttcatcag aacaccccat ctatatcaat cagatatttt 2693041 tgactcttca ttcgaatcta acaatctctt ggcgctttca tataaaaaat aagaggcttt 2693101 gataattgca gtttcatcta ttgtaaatgc agggtggtgc caatcatgat caccgtctgt 2693161 tccaaaaaac gcaaaggatc ccggaatatg ctcaagataa taagcaaaat cttcccccgc 2693221 ggttgatggg gcgggatcaa tgacttgaag tttcgcttta tgtgcagcgt ctcgcaccag 2693281 ccccgtaatt gcctcatcat tacaaagcgg cggcggtccg gaatgccact tcacatttgc 2693341 ctttaacgag aaagcggcag aaatctgctc tgtgactgca aaaaaacgct gtttcacttg 2693401 attacgaacc tctgaatcaa atgtacgaac agtgccctca atgaccactg tatccggaat 2693461 gacattccaa gtgctgccgc cgttgatttt ccctacggtt aaaatcgcgc tttgcagcgg 2693521 gtttacattt ctgcttacaa tcgtttgcag ggcgacaata agctgagagg cgccgataat 2693581 tggatcaaaa ccattatgcg gcaatgctgc atgagcacct ttcccttcta tctctacttt 2693641 aaatcggtca acagcagcca taagcgggcc tgtttttaac cctacagtcc caaccgcgat 2693701 atccggttta ttgtgaaggc caataaccgc atcaatgcca tccagttggc cgtcctctat 2693761 cacttttgta gcgcctgcac ccgcttcctc tgctggctga aataataaac gaatctttcc 2693821 tttcagactg tcttgatttt ccttcaataa aaaggccgca ccaagaagcg ctgccgtatg 2693881 aaaatcatga ccgcacgcat gcatgatccc tttatgttta gacgcataag gcaatcctgt 2693941 tttttcttca attggcaagg cgtcaatatc agccctcaaa gcaatcgccg gaccttctga 2694001 ctcccctgct atgtctgcga acacacccgt ttttagagca gtagggcgaa tctgtatccc 2694061 cttttcttta aggcattttt ttataaaagc agttgtttca aattcttctt ttgacagttc 2694121 aggatattgg tgcaggtgcc ggcgaatgcc gatgagctgc ttttctagcg ttgagagatt 2694181 tacgggatta gactcctctt tcaacgtcag gatgtcattt cctgtagtct gatatggata 2694241 ggagccttct atatttctcc aataatccaa agacatatgt tccgctcctt tccctatccc 2694301 aatatatttt cttcagactc ttcaacataa gatgaaataa atcggttcaa tttatcagca 2694361 agaccgcccg ccccaaatct tatatacttg ctggaaactt tcggattatc ttctttcaaa 2694421 aagcttaaaa aagataaaat ataaatgcgc ctgtaagcta cttgtgtaat tccgtactca 2694481 aaaaaccagt tatcaatgac attgtatacg cctcggttga cgccatatag gttattacat 2694541 ttcttgtaaa agcagagatc cggaagattt aactcctgat gggaaagaag gctttctttt 2694601 ttgtttggtg ccataatccc aatcagctca aagcgttttg caacgcacga aatatccttt 2694661 ttaatttgct ttgttaaaga ctccaaagaa tcaaaccttc tttcttctct aattttaaag 2694721 agaatgctgc attcgatttt ttctccataa atgtctctat gaaagtcaaa caaaaaaatc 2694781 tccaatgtct tttcaaggtt agagcccacc gtcggtttca caccgatatt cataacccct 2694841 aaatgaaatt gatgattgac tgtcgccaga accccataaa ctccattacg cagcccatgt 2694901 atttttgcat ctacatttgc cgtggggaat ccaagctttc tgcctaattg ttttcctttc 2694961 acaaccgtac cggcaatgat cgtcaaaaaa gtcagcctcc tctctcagct tccgcattcg 2695021 atcagacgaa acctaatgat gtgatgaatg taaaacggat tgatgctgcg gaatgccaag 2695081 accgagattt tcccgcaatg tcccgccgcg ataatcttga cgataaagcc ctctttcttg 2695141 aagaatcgga atcacctttt ctacaaaagc atcaagtgtt cccggtatat ccgacccaac 2695201 gataaaccca tccgccgcct cagcgttgaa ccaagtttca attaaggatg cgacacgctc 2695261 tggtgttccg atgaatagag tccgtggaaa agccatttcc tgtgctacct cccgcaatgt 2695321 cagatttctg gcttttgctt ctctcttaat ccggtctgtt gtgctttgaa acgcattctt 2695381 tcccacatcg ccaatatcgg gaaatggctc atccaacggg taaacactca gatcataatc 2695441 atcaaaaaaa cgggccaaat aagtaacagc attttcaatc ggtatcaatt ctgcaaattc 2695501 acgatacttc ttttccgcct cttcttccgt atctgccaca atcgggctga tccctggaaa 2695561 aatccgcaca cttgaaggat cacgcccttc atcagcagct cggcttttca catccgcata 2695621 aaacgctttt gtctcttcta atgaattgga atgggtaaaa atcgcatccg catttttagc 2695681 agcaaactgc cggcctgttt ctgatgaacc cgcttgaaac actacaggct ctccctgctt 2695741 agagcgcccg atattcaagg gcccctctac ttgaaaatac tttcctttat gattcaggcg 2695801 atgaagcttc gcctgatcga aaaactgccc tgttttctta ttgtgtataa atgcgtcatg 2695861 ctcccaggaa ttccacagcc cgcgcacaac atccaaatgc tcttgtgcga tctcgtaacg 2695921 ttcagtgtgt tctggcaaat tagacttact atggttgcgc gccgctcctt cctgcggcga 2695981 agtaaccaga ttccagccgg ccctgccccc gctgatatgg tccagcgaca tcaattgtct 2696041 ggagatagtg aatggctcag taaaagatgt agagaacgtc cctactaaac caatattttt 2696101 ggtaaccgat gccagcgcag ataaaatggt gatcggttca aaacggttta aaaaatgagg 2696161 aatcgatttt tcagaaataa ataagccgtc tgcaatgaaa ataaaactaa acaaaccttt 2696221 ttcagctgtt tgcgcctttt tcatgtaaaa ttcaatattc gtgctggccg agggatcaac 2696281 atcgggatga cgccagccgt cagttgttcc cccgacaccg tgaatcatgg ctccaaactg 2696341 aataaaatct gcacgtgtca tctttttgcc tcctttatct gtgcatgatt agcaagtgca 2696401 agatcaaggt gttcaatgcc gatttcagtt atcccttgat actgattgcc gcgcccgatt 2696461 tcgaccacag gcacatggcg caccccatat ttcacctgta aaatatcccg aagcttttct 2696521 ttctctgaaa catcgatatt ttggaacggg aacccttttt cattcaaata attcttgact 2696581 tcctcacaat acgaacagcc ttttttactc caaaccacaa tgttcacaac atcactcatt 2696641 cttctgtccc tccttaacgt tttgcagcta aaactgcatc gctcagcagc tgataagaca 2696701 gctgtttttc tacagcattt ttgatcggtg taaaaataac aaaatcattg attttgtatg 2696761 tgcctgataa acgtgttaat tcttctgcca cttcttcctt tgttccggca ataatcccgg 2696821 ttttttgcac gatgatgtca tagggctctg tgacgttttc cagataggcc tcagcctgtt 2696881 cgcgggaacc gacgttgacc ttacgcccgt ctttcaaaac cacttttatc gattcacgcg 2696941 acacaatatg tttttccgct tcttcttttg tatgtgccgc aaaaacagcg ggggcaagat 2697001 gaaattcagc ctcagatcct ggcgggagat gcgcgtcaaa tgctcggcgg gcttccttca 2697061 gcacttcctc ttcaccgtta ataaagtaag caaagacaaa agagattccc agttttgcag 2697121 cagaaatggc actctctgtg cttcctccca atagaaaaat acccggcttc cgatcaacct 2697181 gcggcctagg acgcaatgcg gcatagcggt gggtatcagg aaaatcatcc cgaacgaaat 2697241 gagtaagctc ctccagtttt tcatcaaact gacgcaccgg ttttttatat tcggcctgca 2697301 gcgcgtctgt ggacagctga aacccgccgg gcgctttgcc cactccaaga tctatacggc 2697361 cgggagctaa cgctgataga agatggaatt gctccgctac tttataagag ctgtaatgct 2697421 gcagcatcac tccgcctgat gctaaacgaa tttttcttgt gcttgcagca agatagccta 2697481 aaagaacctc gggtgcagac cctgcaatct catcattgtt gtgatgttcg gccacccaaa 2697541 atcggtgata tccacattct tcagccattt gtgccaattt cactgtatgc tgtaatgtat 2697601 cagctgctgt ctccccttca ccaatcaagc tttggtctaa aatacttaag cggatcatat 2697661 caccggctcc tttatgtgtt cttttggttc aaataaatat tccggcgaaa cacggcggag 2697721 aaactgcctc gttctgtctt ttttggtatg gcggaagact tcctccgggg ttccttgttc 2697781 aacaatgact ccttcatcca taaaaacaac ttgatcagag acccttcttg caaactccat 2697841 ttcatgtgta acaacaatca tggtggctcc ggttttcacg atttccagca ttacctcaag 2697901 cacttcaccg accagctccg ggtcaagcgc tgccgtcggc tcatcgaaca gcagcacatc 2697961 aggatgaatg gcaagcgccc ttgctatccc taccctctgc ttttgtcctc ccgataactg 2698021 actcggataa gcgttcaatt tatcttgaag cccgaccttt ctcagttcat tttccgctac 2698081 ggcatacgcg tcttgttttc tcattttccg ggcaatcgtc aagccctcca tgacattttc 2698141 aatcaccgtt ttgtgagcaa acaggtggta ttgctgaaat accattgccg tctgttttct 2698201 gagccagtga acctcttttt tggacggaaa gcggcaatta atcactttgt catgtataga 2698261 aatgatccct tcgtctggac gttctaataa attcaggcac cgtaaaaagg tggttttccc 2698321 tgatccgctc ggcccgataa tcgtcacaac ttctcccttg cgtaccgtga gatttatccc 2698381 ttttaataca tggtggatgc caaactgttt atggatattt ttaatctcaa tcataaagtg 2698441 cctccttgaa atctggctgc ctttctctct aatactccat ttgcggattc taggattaga 2698501 gtcagcaccc aatagataat cgctgctccg ataaacgctt ctaaaaatgc ataattatca 2698561 gaagcaacga tagtcgccgt ccctgtaatc tctgggacag ccactatagc cgcgatagag 2698621 gtggtatgca aaaagccgat acccaaattt gtgaagtttg ggatggaaac cttcagcgcc 2698681 tgcggcaata ttacacgccg aaaggtttgg ctgtatgtca agccgattga ataagccgct 2698741 tcgacctgtc cggtatccat cgccagaatg cccgaccgga tgatttctgt gagataagct 2698801 ccggcagtta aagacaaggc catgatgaca aacatggaga ccggtatctc attagcggac 2698861 cagccgagat gaaaaaaact gctgacttga tctgcaacag gcggtatccc taaataaatc 2698921 aacataatgt gaagaattgc aggtgtactt cgaaagaaag acacataaaa ccttgagcaa 2698981 gccaccaagc ccttaattct aaaaattcta acaattatat ttccaagagc cacgagaaat 2699041 ccaaacacaa tcggcaaaac agccatcatc aatgtcagag gaatggtctt taccatttct 2699101 ttcatggcgg aaacgataaa tggaaagtca aattgcaatc ttctcccccc tcatccgaag 2699161 aaatatatca atgtatgttc atgtcaaaaa cagtaacaat ccttgtttga ttcttcttga 2699221 ttcgtttttc tgccactcga aagaaccatt cgaataaaac cgctacagca taataaacaa 2699281 tcgatagcgc aatgtaaact tcaagagaat ggttgcttga ggtaatcagt gtttggcccc 2699341 ttccggacat atccataaca cctattgaaa aggctagaga cgtatctttt aaagaactga 2699401 tcaccatgtt tcccatattc ggaaacgcct ggacaagtgc ctggggcaga acgattcgcc 2699461 tgaaggcctg actaccgctt aagccaatac tgtacgccgc ttccgtttgg cctttatcta 2699521 cactgcccac ccccgctcga atgatttctg cggctgccgc tgcattgctt aacgcgtagg 2699581 ttgcgacagc agcataaaac gggtccattt ttgatgtatc aatcccgata agccccgtaa 2699641 gcgccgggat cccgtaaaac acgatgaaaa gctgcaccat gataggcgtt cccctgaaaa 2699701 acgagatata cacttttgcc aattgattta caattggaat attatagatg cggggcagtg 2699761 ccagaaagag tcctaataca aaaccgaaaa gcaaggacag tgttaaaatg tataatgtaa 2699821 ccggtaaata agcggttaac gtcggcacaa aatctccaat catgttcata tcaaacgctt 2699881 tttccatcac tgctccctct ctttttacct aatactgctc tttggaatag tcgtcaccaa 2699941 gccatttcaa actgagcctt ttcaacgttc cgtcatcaat gatttcctgt aaggctttat 2700001 caatatcgtc acttaacgtt tgttcatttt tgttaaacat aaaatacact ttggcatttg 2700061 aaagcacatt accgacggtt ttttctttaa tagtgctcgt cttgttttga aagtctactg 2700121 caaaaggcgt tgagatcgtt gcgtccgcac gccccgattt cagctgattc gcagtctcat 2700181 ttgcgccttg gccctcatag gcaatctcaa acggccgtcc attatcctca ttccattttt 2700241 tcagtacaag cgctccgttg gaggttgcac tcgtaatcac ccgttttcct tttaagtctt 2700301 caattccacg gatcgtatcg ttattttgaa gcacagtaat ttttaaagga aaatggttgt 2700361 aagcaacctt gttaaacaga aattttttct cacgctcttt gcttttctcc atttgatgtg 2700421 ccacgatatc gactttatgc tgtccgaggc tgacaagcag gttggaaaat tccatcgttt 2700481 taaatgtgaa tttataatgt ggcaggcgct tatcaagctc tttgatcagt tcgacatcat 2700541 aaccggttaa atcgcctttt tcatcgataa agcaaatatt cggaaattgg gttccagttc 2700601 cgaccgtgat cgtctgtacc ttcttttgcc cggctcccgt cgtttgactg cctgcaccgc 2700661 aagctgacag aactgttata agcgaaaata atattgccat gaatgctgtt ttcgttttca 2700721 tctcatcgcc ccatttattt ttcaaaactt gattttgaat aatctgcccc gagccatttt 2700781 cggcttagtt tttttagcgt tccgtttttc tccagctttt taatcgcttg atccgtgtca 2700841 tccgccaagg tttggctgcc tttattaaac ataaagtaca cctcggtatc taataacacg 2700901 tcaccgactg tcttttggcg gaaggcgtgc gttttattct gaaaatcgac ggcaaacggt 2700961 gtagctatcg ttgcatctgc gcgcccggtt tcaatttgat tggcggtatc attgcttccc 2701021 tgtcccgcat atttcaaatg aattgggctg ccgtgcgttt tgttgtactt tgtaatataa 2701081 tctgccgcat ttgacgtggc gccaactatg actgtttttc cgtgtaagtc ttttaatgta 2701141 tgaatcttgt gattatcctc tttcaccgtg atgtacatcg gcgagtagtt atatgggact 2701201 ttatgataca aaaaacgctt ttctcgttct ttatttttgg ccatattgtg cgcaatcaca 2701261 tcaatttttt tatttccgag actcgtcagc aaatttgaga aatccatcgt tttaaattca 2701321 aatgtatatt gaggcaactc cttatcgatg gctttcatca cttcaatgtc atacccggtc 2701381 aattcacctt tttcatttaa aaacgcaata ttcggaaaat ctgttccagt gccgactatg 2701441 accgtttgag cctgacgatc tgttttgtta tttgtttgcg aacatccccc gccaagtaat 2701501 gcaaacactg acagcagcaa aaccaatcct ttacgcttat tcataggctg cctcacatca 2701561 tgcccagctg ggcgcaccta aaagcgttgg gttaaatcgt tccggaatca gaaccttgtg 2701621 catcatcaca cctatgtccc cgtctttttc ctgctcaaaa tacacttcat accctctcct 2701681 tctgtacatg tcagcaagcc aaggatgctt gcgcgccgat gtgccgagtg tcagcgcagg 2701741 agccttcagc atatctcgaa gcactttttc ttcaacatac gtaagcagct tacttccggc 2701801 gccttgccct ttatattccg gcagtgtcgc aaaccaccac acaaatggat attttgaagg 2701861 aggcgtctca ctctcccacg ggaacctgat tgtaatcgtt gaaatcagct tcccatcccg 2701921 ctccagcaca atcgctgaat gatgttcaat attttctgat accatttgga tatcagctct 2701981 cgtggatggc caatcaatat ccagctgccg aatgggctga aatgcgctgt taaccagttt 2702041 caacagctcc gatgcatctt caacagttgc cagtcgaaaa atatcatcac tcatttttgt 2702101 cactcctctt cacaaaatat ataattccta tttgtttact aagcttttat tgtttatact 2702161 ataaagcata ctctgatctt tgactaatca aaaaaagtaa accttcactt cagtaatttt 2702221 aatgatgaaa aacaggaggg agcacattgg agttacgctc aatcaaaacg tttcatacga 2702281 ttgtaaaatt tggaagcttc tataaagctg cagaaatact caactactcg cagccgacga 2702341 tatcgatgcg tatgaagcaa ttggagcagg atttaggcgt actgctgttt gaaagaggaa 2702401 aaagcctgca gttgacaaaa gcagggaagc ttttttatga acgaacagga gatcttttga 2702461 tgcaatacga ggcgcttaaa cacaacctct ccgacttaaa ggaagaagag gcaggcatta 2702521 tcaacatagg ggtttcagag ccaaccgcca gtctgatatt ccccgagatt ttaaaggatt 2702581 tcttaatgga ttacccaaag ataacggtta atatcaaggt tgatgacgcc aatacctgca 2702641 gtcaaaagct cttagacggg acgattgatt ttgcagtctg cggcgagccg gagctgattc 2702701 ttgaaaatta ctaccatcca tttttttatg acacattaaa tgtgattgta tctgatcaac 2702761 atccgctcgc tgagaagaag gctgtccatt tgtctgattt agcagaagag cgcttcatat 2702821 ttacgcccgc caattgcccc attcgcttac aaattgaaca gcatttacat agagaactcg 2702881 ggaatcgcta caaaaaaatg gagctcacaa gcagcatgtc acatgaatat tacgtacgtg 2702941 aaaacatcgg aatttcaatc tttaccagca ccgcacattc taaaccgttc aacggcacta 2703001 aagtcattcc aattctgaac ctggatatca ccccgcccat agggctgttg acaaatcaaa 2703061 aagaagttca ttttgaccgc gccacgaagg acttgatcgc ccggataacc aaacgttttc 2703121 agcagcgcag caaagaattg gaaggaacct ctgataagac cattacagga taactgaaaa 2703181 aataaaaacc acctcctgat tcatcaggag atggtttcac ggtttaaagc tcgatcgtct 2703241 caccgaccga catgactttg ccgactccgc ccggcaggct gtcagcgaat gcttctgggt 2703301 cttgttcgat gaccgggaat gtattgtaat gcaccggcac gacctgtttt gcgcgcagcc 2703361 attcagcagc aagcttggcg tcttcaggcc ccattgtaaa gttatcgcca atcggaagga 2703421 aagcaaggtc gatatgattc aattcgccaa tgagtttcat atcagagaaa agtgccgtat 2703481 cgcccgcgtg gaaaatcgtt ttatcttcta cagtcagcaa aataccggca ggcatgcctg 2703541 tgtaagtgat cgttttgttt tcttcatctg tgatggctga tccatgaaag gcctgtgtga 2703601 gcttcacttt tccaaaatcg aactggcggg agccgccaat atgcattgga tgaacattca 2703661 agcctttcca gcctaagtac acagcgagct cgttcggggc tataaccagc gcgttatttt 2703721 gcttggcgat ttgttcagta tcaccgacat ggtcattgtg gccgtgcgtt agtaagatga 2703781 catccgcttt tacatcctcc ggctttatat ccgttaatga attccctgtt aaaaacggat 2703841 caaaaataat atgatggtcc ttcgtttcca ctgtgattac agaatgtccg tgatatgtca 2703901 ctttcatttc tttcacctcg tcacatgatt ttgttttttt tattttccct ttttaaaaag 2703961 ctgaaaaact tatgttgttt gattcttgtt aatgacattg aggcctccgg tggcttcaat 2704021 gacagtccct gtcacaaggt ctgagttctc ctcacacaag aaagcgataa tcctggcaat 2704081 atcctcgcct gtaccggatc ttcctatcgg cgttttttct ttgccgattc gcattctggc 2704141 ttcctctatc gatgcttctt tcatgtcgcc gacaatgtct cctgggcaaa ccatgttggc 2704201 ggttatgccg aattcggctt cttcaatggc aattgtcttc gtcaaagaag ccaagcccac 2704261 tttcgcagcg ccaaatgccg atcggtgaag ccagccgggc gcgtgagccg caccttggaa 2704321 tccgtacgta ataatgcgtc caaattgctg ttttctcata ataggaataa ccgctttgaa 2704381 taaatgaaag acggcgctta aatttccttc cagcatgcca taccattcat catcagtata 2704441 atcggctaac tttttacgtt caaatatgta tggtccagcg ttgttaatca aaaagtcgat 2704501 ccttccgaag cggtttaagg cagcctctgc aatacgcagc agatcttctt ttttggtgac 2704561 atcacctttt acaaattgca gccggtcaag acaatcggga caggcttcct tcaggcggct 2704621 gactgcctcc tcatcctgtc tgtaattgac tgttactgaa tacccctttg caagcaacgt 2704681 ttcagtcact ttgcggccta aacccttcga accggcagta attaaagcat gtcgcacatg 2704741 aatacctccc aaagcaacgt cgccgctttc aataaagtgt ttcttcttct actttactat 2704801 aaaaggcttg caatatcact ttttacactt tggcatacaa aaaaagctgc ctgtacagac 2704861 agcttattct gcaggagatg aagactcctg atcaggcata tcgacataac cgctttgata 2704921 tgcttctgaa atgagccttg ttgtctcctg gctttcttgt tcatcataaa tatagcgttc 2704981 cggttctttt ttcatcattc tgcctcccat cattatagag gtaggttggc tataatgacg 2705041 ggattttatg aaggaaattt taacaaactc ctgctgccac gcaagctttc gctttttcaa 2705101 gcgcctgttc cacctgtttg aatccggtgc ccccggcgct cattcttttt tcaactgcgt 2705161 agtaagggtc taacacagtg taaatatctt cttcaaatag tgtgctcgcc tgctgaaact 2705221 cgccaaacgg catatcgctt aaatagatcc ctctttcgat gcatgtgtac acaagtttcc 2705281 cgaccacttc atgcgcttct ctgaacggca ttcctttttt agctaaataa tcggccagtt 2705341 ccgtcgcgtt tgaaaagtct tgttttgttg cttgcttcat gacgtctttg tttacagtca 2705401 ttgtttggat catgcctgtg aagatttgca ggctgccctc caccgttttc accgtgtcaa 2705461 acatgccctc tttgtcttcc tgcagatctt tgttgtaagc gagcggaagt cctttcatga 2705521 tcgtaaacag ccccatcata tcgccgtata cgcgtcctgt tttgccgcgg atcagctccg 2705581 ccatatcagg gtttttcttt tgcggcatca tgctgcttcc tgttgcgtac gtatcgtcaa 2705641 gctcgatgaa tttaaactcc tgcgagcacc ataaaatgat ttcttcagag aaacgggata 2705701 ggtgcatcat cagcatactg ctgttgctta aaaactccaa aatgaagtct ctgtcgctga 2705761 cgccgtccaa gctgttttca taaatggcat caaagccgag cagttccgct gaataatcac 2705821 ggtcaattgg gaaggttgtt cccgcgagcg ccccgcagcc gagcggagat ttgttaatcc 2705881 gcttcattga atcctgaaaa cgctccttgt cgcgctcaag catccagaaa tacgcaagca 2705941 gatggtgagc gaatgaaatc ggctgggcgc gctgcaaatg tgtgtagccc ggcagaatcg 2706001 tttcaacgtt cgcttccgcc ttttcaatca gcgcactttg gaatgcctca atcagctcga 2706061 tgatgtggcc gacatgattc ttcaagtata aatgcatgtc agtcgccacc tggtcattcc 2706121 ggcttctgcc ggtatgcagc ttgccgccaa gaggaccgat ttcgtcaatg agcattttct 2706181 caatgttcaa atgaatatcc tcataatcga ctgagaattc caatgctccc tcctctgctt 2706241 tttgcaaaag ggtattcagg ccctctcgga ttttcaactc ttcttctgct gtcagaatac 2706301 cgcatttttt cagcatggca gcatgtgcga gagaccctgt aatgtcttca gcaactaaat 2706361 tttggtcaaa tgatatggac gcgccgaact cgtcgaccca tttttccggt gttttttgaa 2706421 atcggcctcc ccaaagcttc ttcatgcttt aatctgctcc ttctttttca cgatgctgtt 2706481 cacttttgtc ggaagtcccc aaagctcgat aaatccgatt gctgcatggt gatcaaatgc 2706541 atcgtctttt gtatatgttg caagtttttc atcatataga gagtattccg atttacgtcc 2706601 ttctacaatt gcatggcctt taaacagctt cacgcggaca atgcctgtga catgcttttg 2706661 cgtttctttt aagaaagcgt gcagcgcgtc ttttaacggt gagaaccata agccgttgta 2706721 aatgatttct gacatttttt gctcgatgat cggtttaaag tgggctacct ctttcaccag 2706781 tgtcaaatct tctaattctt tatgcgcttt gatcagtgtc atcgcaccag ggcattcgta 2706841 tacttcccgg gatttaatgc cgacgaggcg gttttccacg tggtcgatac gtccgacacc 2706901 gtgcgcgccc gccatttcat tcagcttcaa gatcagctca gaaagcgagt aggaaacacc 2706961 gtcaatggag acaggcacgc cctgttcaaa tgcaatttca atcacttccg gcgtgtccgg 2707021 cgttttttcc agcggagctg ttaaatcgta tgcaccttct ggcggcgccg cccatggatc 2707081 ttctaaaatg ccgcactcat tggcgcgtcc ccagaggttt tggtcgatag aatacgggct 2707141 gtcaagattg atcggaatcg gaatgccgcg gctagccgca tattcaattt cttcttcacg 2707201 tgaccactgc cattcgcgaa ccggcgcgat gacttctagg tcagggttta atgatttaat 2707261 ggagacttcg aaacgaacct ggtcatttcc tttccctgtg catccgtggg caatcgcctg 2707321 tgcatcttct ttttccgcaa tttcaaccag ttttttcgcg atcagcggtc gagataatgc 2707381 cgaaacaagc gggtattttc cttcatacat tgtgtgggcc tgcaaagaga taagcgcgta 2707441 atcctgtgca aattcttctt ttgcatcgat cacgtaggag tttgtcgcgc cgacttcaag 2707501 cgctttctgc tgaacaaatg ccaaatcttt gccctcaccg acatccaggc agcaggcgat 2707561 tacattatat ccttgctcct gaagccattt tattgcgacg gaagtatcaa gacctcctga 2707621 gtatgctaat acgacttttt tctgttctga catgataaaa atcccctctc aaccgtgttt 2707681 ctattttgta taaaaataaa ttatatttaa taaaaataca ttttgtatgt atacacttta 2707741 acaagtacgt ttcgtttttt caagcctttt ataaaaaaaa cttcacctaa atttcaggtg 2707801 aagtttcata gtatttattc atttacttgt cttttctgat ttctctgacc acatgcgcaa 2707861 gttcgggaat aatcagctta ttcattgcca gctttactgc gccgcttgag cctggcgttg 2707921 agaaaacagc ggtatgctga atgacgccgg cagttgctct cgacatgatt gcggcagagc 2707981 cgatatcctc tgtataactc agcatcctga atatttctcc aaagccgggc agttctttcg 2708041 aaaacagcgg cgttatggct tcaattgtga catcccgatc tgctatgcct gtccctccgt 2708101 ttaagagtac cgcgtctgtc tgttcatcca tgcagcccgc aagcactgac cgttgcaaag 2708161 catccttttc gtcttttaca atttcatatg cggcaatatg atgaccggct tcttctaaaa 2708221 atgagatcat cagcttgccg cttttatcgg tttcatctgt cctcgtgtca ctgacagtaa 2708281 tcactttgca ccgaacgata tcgggagctt cttgtttatg ctcttgaacg ctcattggcc 2708341 cacctctttt atgttttctg tctgtcacta tcatgcatca acaaaaaagc acattcaaga 2708401 gaatgtgctt tcatgcgatt tattttgcta aacgaacaac gtcgcgcgca atcatgactt 2708461 cttcatcagt cgggatgatc atgactttta ctggagaatg cggatagctg atgaaagctt 2708521 cctcgccgcg cacgttatta agcgcagggt cccagtatac gcccatgaat tctaaaccgc 2708581 gaagaacgcg ttctctgact tccacactgt tttcaccgat accggcagta aagatgatcg 2708641 catctacacc gctcattctt gcagcgtaag aaccgatgta tttgtggatt ctgcttgcga 2708701 atacttcaag agccgtttcc gcgcgctcat ttccttcttt cgtagcttca acgatgtcac 2708761 gaagatcgct tgagaaaccg gaaatgccga gcagtccgct ttttttgttt aatgtattca 2708821 gtacttcgtc agccgtttgg cctgttttct ccatgatgta tgggatcagg gcagggtcga 2708881 tgtttccaga gcgtgtgccc attgctacac cggcaagcgg cgtaaagccc atggatgtgt 2708941 caatagattt tccgccttca acagcggcaa tacttgctcc gtttccaagg tggcaggaaa 2709001 tcaggcgcaa gtcttttaac ggacggccga gaagctctgc cgcacgctca gttacatatt 2709061 tatgtgaagt gccgtggaag ccgtatttac ggatgccgaa tttttcatag tattcatacg 2709121 gcaagctgta aaggtaagac tgctcaggca ttgtttggtg gaatgctgta tcaaatacag 2709181 ctaccgcagg aacatttgga agcacttctt tgaacgcttt aattccaacg atatttgccg 2709241 gattgtgaag cggtgccaat tcagaaatat cttcgatttc cttaatggtt tcatccgtta 2709301 ataaaacaga atcgctgaat ttttctccgc cgtgaacgac acgatggcca attccgtcaa 2709361 tttcattcaa gtctttaata atgccgaatt ccgttaactt attcagcagc attttaacag 2709421 ctaccgcatg atctggaata tcagttactt ctgtattttt ttcgccgttc acagaaattg 2709481 tgaatacgct gtcggcgata ccgattcgtt caactaaacc cttcgttaaa acggtttctg 2709541 aaggcatttc gaaaagctga aatttcaaag acgagcttcc tgcgttaatt gcaataattt 2709601 tggacatgat tgacgctcct ttatactctg tatcaacaac ttcgtttttc gtactttttt 2709661 cccggtgaat atcaacatct tctccgaaaa atatctgact tttccattta aacattgtca 2709721 tgtcggcttt tcaagtcaac ttgcgtattg ataacgctta caataagaag tcgttatttt 2709781 cagacacatt cactataggt tttgtattga tgaacgctta caatttgcgg tttttccctc 2709841 tgtattttgt gtttcaaagc tggattcaat tcgtcaagtc cggtcttcaa aagcataaat 2709901 aaaagcagct taggcatcga cctcatacgg ctgtctaagc tgcttttaaa acacttactt 2709961 ttctttttta aaccattcat caaattgagc catcatatca agcatcgcct tttgattgga 2710021 gaaagacgga agattcgcaa gcagaatttg ccccggcgct ttcgtattct ctccttgttt 2710081 ctgaagcaca aggatgcttt tggcatgagc ttcgtcttta aaaatagatt ttggcagctg 2710141 caacagtgcg ttgatatgaa ccttatcttt gaaaaactgt ttcagcttgc cgctttggga 2710201 gctctcaaac aaatgattcg gaatcataaa aaataagtag ccgcccggtt tggtatgctt 2710261 gacgctctgt tcaataaaca gatgatgagc gaaggaatgg ccttcgtcag ctttgagctc 2710321 aaacgcttct gctccttcgt cattcggata atagccgact ggcagatcac aaatgaccgt 2710381 gtcaactgga tcgataaaca acggctcaag gctgtcctgg tggaaaagct caagctcttt 2710441 tttcagaagg ttcgcttggg cataggcgat cttcaagagc acatcatcaa tttcaatgcc 2710501 aaagctgttt gccgtttttt cagacagctg gttcagcacg gtaaacagaa ggttcccagt 2710561 tcccagggct ggatcaagaa tggtcagttc ctttttgtcc gccataaatt tattcaccaa 2710621 atagctgatg aaaagcccga tcgtatccgg cgtcatttgt ctgtttggat gcgagatatc 2710681 tttcattcct ttaaggacgg caagctgaaa agccttgcgt acccactcat gctcatacgt 2710741 gccgaattcc gctttttcaa gcagagcctg aagttgtttg gttttctgat cagcaggcag 2710801 tttcagctga tccgtttttt caagaaaata catttctcct gcttcggcca gcgcctctat 2710861 atatgaaatc tgcaattcat tctttatcat aatcgcggct tcgtttaaca gctcatacac 2710921 cgcacctaca tggtcttttt gcatattgtg ttcctccttg ccatgaaaaa agctccggcg 2710981 gcagcctgga gcttttttcc ctgcttactt tactaatgcc ttagcagcct caattggctt 2711041 ttcatagttc gggtggtttg ttgcttcgct tacatattca gcgtaaacga cttttccgtt 2711101 ctcatcaagg acaaatacgg aacgcgcaag cagacgaagt tctttaatat acacaccgaa 2711161 cgcttcgcca aatgacatat ctctgtggtc agacagtgtt tccactttgt caattccgtt 2711221 agcgccgcac cagcgcgctt gcgcgaatgg aaggtctgca ctgattgtgt agacgttgac 2711281 atctccaagc tttgcagctt cttcgttaaa acggcgtgtt tgtgcatcac aaacacctgt 2711341 atcaattgaa gggataacag aaataatcgt tacctttcct ttcatgtcag ctaacgattt 2711401 ttcttcaagg ctgttagtca gcactgtgaa atcaggagct tgatctccta ccttcacttc 2711461 ttgtccgaca agtgtaaccg gaccgccttt gaatgtaatt tcagccatta taattcctcc 2711521 cttttgtatg tatgtctcta tcatagtaaa gtttcctgca aactgcaaag tttatgccaa 2711581 aaaaaagtta actgcggcca gcgcagttaa ccttttttta ataattcata ttgttcattt 2711641 ggttttgatt ttggccttgg ctttggtttt tgttattttt cttgaacatt tgctggatgc 2711701 gctcgagtgt ttgaggggct gcgtctaaaa ttttctctat taaatgggta ttttcatcta 2711761 aatgaagcat tctgatgcct gtcgatccga caattaaaaa cgcgatcggc gtaatggaca 2711821 caccgccccc gcttccgcct ccgaaaggaa gtttctgttc tcttgtctca tcgtcttccg 2711881 atttcttttc ggccggcttt ccgccaaact cgcttccgcc tgcggcgaat ccgaatccaa 2711941 ctttagaaac agttaaaatc acacttccat caggcgtttc cactggatct ccgatgatgg 2712001 tgttaacatc aatcatttcc ttcaagtttt ccattgcggt tttcattaaa ccttggatgg 2712061 gatggtctgc catatacgct tcctccttaa actgatgaat cattctttga agtcattcta 2712121 gccgacggat tcttctttaa tacggatagc tcccgtccgt atttgacgaa tttgaaagct 2712181 gcaagcatag catgtccaaa gcgaaaaaag aatatacact gaaaatgggt cttggaaaca 2712241 gggacttgaa acgacgggat cacctcatag acaggtttat tcacaaagtc caggtggtcg 2712301 tagagcattg ctgcgatacc gcccttcacg ccccatacag caccggttaa cacacctgtc 2712361 actgccgcgt cctgaattcc gattactgta acccattcta gttttgtgat atgtaaatgc 2712421 gcgagaaaag acgcgctgat tttccgcagt ctggtgacct gatgcaaaag catttcgatt 2712481 ttattaatgc tttgctgcac atcgttttgt gtaatttttt tctttccgct gctttttttc 2712541 attttggatt cagttttttg tttgatatcc actgttccgt cttctttgtt caccttaatc 2712601 gccgggattg tttttttgat ccttataagg ccaaacagcg ccgtaatctt caaggtcaat 2712661 ttgtcattat catcggcatg aagatactcc agcgcgacat ggattttcat tctgagaagc 2712721 agtacgatcc ctatgagaat aagaatggct gtcagtacat acaccatatt cttcacttcc 2712781 tctaggagca ttatcgccaa ttcctaaaaa aataaacccg gacggaagtc cgggttatcg 2712841 gttatttgcg gtataatttt tcatgcacca cggtggtatc cgcgatgtaa tcatgaatcc 2712901 cttgttttgt aggtgaaaag gcaacaacga tatataaaat ccaaatctta tcaatatacc 2712961 gtccaaccac ttcacgaaaa atcactgtac tccatgtcag cttgctatct tgcttcacag 2713021 aaaccacttt gaggccgaac accattttac caagcgtctg cctgaagtat tttgtcatga 2713081 gtgcgaaata ggcaagatac acaataagcg ttgtcacact gtaggccgag aaggtaaaca 2713141 tgccggatgt tttcggcaga tccaatacgg taaagagggg agaaacgagc aaatggttta 2713201 atccccatat cacgagccaa tcaagcagga aagcccagaa acgaacccaa aagccagcat 2713261 aggcatgtgt cagcagctcc gcttcttgcg ggcctttgat gtcattgcgc tctaactctt 2713321 catatgtcgc gtccattatt gttccctcct acttcgcata gagatacatc attctcggcg 2713381 aaccggattg cgatagaatt tctctcatat tcaaaaaatc aatttcactt ttaaacattt 2713441 tgttcgcgcc catggaaaac agtgagccta atccgaagct ttcctcataa gaaatgacag 2713501 aggcgttttt caaatccttg tgatcctttt tcatggccgt aatggtatcg tcataaaaac 2713561 caagctcatc aacgaggttc agttttttcg cctgccgtcc gtcatacacg cggccgtccg 2713621 caattttctt tacctctgct ttcggcatgc cgcgcccttt tgaaatgaca tcaacaaagc 2713681 cttcatacga attatcaacc atcgattgca tgatgttttt ttcttctttc gtcatctcac 2713741 gggaaggaga cataatgtcc ttatgggccc cgctcttaat cgtttcaaaa gaaatgccaa 2713801 gcttgtcggc aagctttgaa taattgacgc tttccataat gacgccgagt gacccggtca 2713861 gggtttccgg tgtcgcaaaa atcttatcag ccgctgttga gatgtaatag cctcctgatg 2713921 ctgccatcga acccattgac acgtaaatcg gttttttcgt ttctttcttg atttcttcca 2713981 gtttcttatg tatttcagca ctttcataca ctccgccacc cggagaattc accttcagaa 2714041 cgataccttt gaccgtcttg tcatcttttg cgcgctcaag gttttttaag aacgttctgt 2714101 ggttatatcc gtctgcacca agcagactgc ttgagtcccc attatcctga atggtgccgc 2714161 tgacctctaa tacggcaatt ttacttgagg gactgccgtt ttccagcgtc ttctcctgcg 2714221 attcatccgt cagtgatgtg agatccgttt gagcgccttt gacgctttca aagaaactca 2714281 tagagatgct gacgataata gacacgccga aaatccccag agcaatcact aatgcaatcc 2714341 atctttttgc attcattttt tctcctcctt tttcctaaac tctctcatta tacgattcaa 2714401 tatgaaaaat gtttcacttc atgagaaagc tccggcttaa cgggctgccg gcaaacgtgg 2714461 tacacttatg gccaaaggta ttttatcaca aatactggat ggcagaaaaa cttaaatatg 2714521 acagcaaagg ggaaatggga tatgaccgat caacgccgta atgtttattt ttttcacaaa 2714581 caggatcagg aaacgaacga acaagcccgc tcgttaacac aattagcgga agagcatgga 2714641 tttaccgttg tgaaccagca ctcagacgcc aatattatcg ctagcattgg cggggacggc 2714701 acatttttgc aggcagtcag aaagacgaat tttcgtgacg actgcttgta cgtcggcatt 2714761 accaaaaagg ggaaagctca tttatattgc gactttcata gtgatgagcg agaaaaaatg 2714821 gtcgatgcaa tgacgtttga acaaattgaa gtgagaaaat acccgctgat tgaagtgaca 2714881 gtggatcaag ccagtccttt tcactgctta aacgaggtat ccatccgctc aagcatcatc 2714941 aaaacctttg tgatggacgt gctgattgac gatctgcact ttgaaacgtt tagaggtgac 2715001 ggaatgatta tctcaacgcc tacagggagc accgcctata acaagtctgt tgcaggagct 2715061 gttgttgatc cattgcttcc atgcatgcag gtatcagagc ttgcatccct taacaataat 2715121 acctaccgga cactcggctc gccatttgtc ctcagctctg accgaaagct gacccttcgt 2715181 gtggtgcagg acggcaacga acacccaatc atcggcttgg acaatgaagc actcagcacg 2715241 agaaatgtga aaacgatcga aatcaaactg tctaataaga aaatcaaaac agtcaaacta 2715301 aaggacaatt cattttggga aaaagtgaag cgtacttttt tatagaaaat aaaaggacag 2715361 gctgctgcct gtccttttat gatttctcat atacaatctg gccgttaatc acggtttttt 2715421 taatctctaa aagatgaagc tgtgcggggt caatggcaaa cggatcacca ctgagaactg 2715481 taaaatccgc gtcatagcct tccgcaattt ttccgcgtga cttctcttta taaatgatac 2715541 cggcgctacc ttctgtataa agctttatcg cttcatatac aggtaaacat tcactttcat 2715601 tatagcttgg cccgttttgc tcatgactgc ttttccggag gaccgcggac tggatcccta 2715661 gaagcgggtc aacaggctca atcggggcgt ctgaaccgcc cgcgcataaa atgcctttag 2715721 atatgagggt tttccaggca aatgcagtct tcatccggtc ttttccgaga cggtcaatga 2715781 cccacggaaa gtcgcttgca acgaagtgcg gctgaaggtc aagtgcgatc ggcatgcgtg 2715841 ctgctctctc gattaattcg ttatcaagca cttgagcatg aataagccga tcatgccggc 2715901 cgtttttggg cggatgcttt tctattgcgt tcagcacttt ttcaaaagca agatcgccga 2715961 ttgcatgaac agcaacctcc atcccttttt ctctcgcttt gcgaatgagc cggccaaggg 2716021 tttcgtcatc gtgaacctga acaccatttg ttgatggatc atcctgatat ggttctttca 2716081 ataaagccgt tctcccgcca agcgccccgt ccgcaaagat tttcatagca ccgaactcca 2716141 catacgggcc ggacagcttc tccagctgct cccatcgatc gacagcttca tgatgaacga 2716201 gcaaatggca gcgaaacgga tactttccgc cagcggcagc tttctcataa gctttcatcg 2716261 gcaccgaaac atcaccataa taggacaagt cttccgaatg accgcccgtc aggccttttg 2716321 tccagcaatc ctttattgca gccgttaatg cctcatcaac atagtgctgg gagactggcg 2716381 ggacagcctt cagaatcaaa tcctgcgcct tatcaaacag gagtccggtc ggctcgccat 2716441 ttgcatcttt tacgatgact ccgccgtcag gatcaggagt atttcttgaa attcccgctg 2716501 cttgaagagc cgcagaattg acagctattg catgccggca tatacgcttg agcaagacgg 2716561 gcctgtcagg aaacaggcga tcaagatcat gcttagtcaa gtagtcaggt gtctcaaact 2716621 gattttcatt ccagccttct ccaatgagcc aatcgttttt aggaagctgc cgctctcttt 2716681 ccttcgcagc ctgtaaaatt gaatctttcg acgtcagtgc ggacagatcg agctgaagct 2716741 gtttctcacc gtggccgatc aaatgtagat ggctgtcaac aaaaccgggg aacatcactg 2716801 ctccgttcag gctgatttct tctgtttccg gcgacccgta cttttccttc aaacgttcat 2716861 agctgccggt gccttttata acaccatcct caacataaac tgcctcagtc cgatcgcctt 2716921 cttcgagcat cgtataaatg aaaccgccgt gccatatcgc cttcattcac gttcactctc 2716981 tttctttacg cctttttatt ggctttgagc tgttcttcac gttttcttaa ttccactcgt 2717041 ctgatttttg cagaagccgt tttcggcagg ctttccacaa attcaatttc tctaggatat 2717101 ttgtatggag cggtaatcgt cttcacatgg ttttgcagca ttttgacaag ctcatcactg 2717161 cgtttttcat gattttgcag gacaacatat gcctttacga tggagcctct gatttcatca 2717221 gggcttgcga caacagcaca ttcttttact tctgggtgct taacaagcgc gtcttccacc 2717281 tcgaaaggcc cgatcgtata gccggagctg ataataatat cgtcatttcg gctttcaaac 2717341 cagaagtaac cttcctcatc ttttcttgct ctgtctcccg ttaggaaata atcgccgcga 2717401 atttgtgttt tcattctttc cggatcttta aaatactctt taaagagcgc aggcgtactg 2717461 aggtgaacag cgatatcgcc aacctcacca ggtttgcaga tttcaccgtc ttcatttatg 2717521 atctccacct gatttcccgg tgtcggtttt cccatgcttc ccggtttaat aggcgtatct 2717581 ttcaaaacac caaccaaaag cgtgctttct gtttggccat atccgtcccg taccttaatg 2717641 ccaaagtgct tttggaaaac atcaatgact tcacggttga gcggctcacc tgcggaaaca 2717701 gcgctgtgca gggcagaaag atcaaagcgt ttcaagcctt caaccttcgc cattaagcgg 2717761 tattctgtcg gagtgcagca gaaaacattg attttgtagc gatttaaaag ctctagatat 2717821 ttttctgctt tgaatctgcc gtggtacaca aaaccggttg ctccgctgcc aagcaccgct 2717881 aaaaacggac tccataccca cttttgccag ccaggggcag cagttgccca gacgatatcc 2717941 ttttcagaaa tgtcaagcca agcgccggca gaagttttta aatgagcaaa tgcccatcca 2718001 tgtgtatgta caacaccttt cggctgacct gttgtcccgg atgtataaga taagaaagcc 2718061 atatcatctc ttgttgtgtc agctgtttta aattggcttc cgtccgcttc aattgataag 2718121 aggtttttcc agccggcatc attttcacca atagacagtg taatcagttt gtcagccgta 2718181 ctgacatccc ggaaagcgcc aataaattcg gagtagacga tagcgccttt tacctctgca 2718241 tgttcaatcc ggtattcaag atctttcgcg cgaagcattt cggagcacgg aatgacaacc 2718301 attcctgatt tcaggatagc caaataaaca gcataggctt caagcacccg cggaaccatt 2718361 acaatcagct tgtctccctt tttaaatcca agatcagcta aggccgctcc gattttattt 2718421 gtttcttcca tcagcttttc atacgaccaa gattcttgct tgcccgactc gtcctcccaa 2718481 agaagagcgg ttttttgtcc agcagcactg aacttttcca tttcattcac taaattatat 2718541 tgcacagggg caattaaatc ttcacgtttt aacacgaaca actcctcact ttctccaccc 2718601 attatacata aatacaggct ctttccgtaa ggatatgcct aaaagcaacc tctgtaaaca 2718661 tagattttat aggccgctgg tcctttttta tatgtaaaaa atgaaaaaga gtggggatac 2718721 ccccactcct aagccattat gtgaaattgt aaattagaat tgtcctccgc ccatgttttg 2718781 ttgagcaaaa gatacaagac gttttgtgat ctctcctcca acagaaccgt tagcgcgaga 2718841 agttgtgtct gctccaaggt ttacaccgaa ttcagaagcg atttctaatt tcatttggtc 2718901 gatcgcttga gcagctcctg gtactaaaag gttgttgctg ttacctgagt tattgttagc 2718961 catgtgtctc acctccttgt gagtatagaa tgtgtcaaaa cacatggctt cattcagaaa 2719021 aactttggta attgtataca ggagctgaaa attgatttaa aagagttcag cgaatttatc 2719081 gttagcttct tgttcgctat aaagggtcat tgtctcaatg ttatctaccg cttcttgaat 2719141 atacggctcg aaatcaacaa agctttcaaa gtgttcaatt ttctcttttt tagggcgtgt 2719201 tttcgggctt ggcggtgtaa agatcgtgca gcagtcttca aacggctgaa tacttgtctc 2719261 atatgtgcca atttcccgtg atttttcgat gatttctgtt ttgtccatgg cgattagcgg 2719321 acgcaaaatc ggtgttgacg tcaccgcatt aattgcatac atgctttcaa gcgtttggct 2719381 cgctacctga ccgaggcttt ctcccgtaat aatggcaagc ccgtttctct tttctctgat 2719441 tctgtcggct atctgaagca tgaggcggcg ggttgccgtc attgtgtaat tttcaggaat 2719501 ttgtttttgg atgagctctt gcgtttttgt aaatggaaca atatgaagtg tcatgcttcc 2719561 cccaaaacgg gacagacatt tcgccagatc cattaccttt tgctttgcgc gctcgcttgt 2719621 gtatggcggg ctgaagaaat gaacagcttc taccgacaat ccccgtttca tcgcataaaa 2719681 accggccaca gggctgtcaa aaccgccaga aagcatcagc atcgcttttc ctgctgaacc 2719741 aactggcagc ccgcctgcac ctttttcatc acgaattgtc aaaaatgttg cttcttccct 2719801 gatttcgatt ctgagcggga tgtctgggtt gcgaacatcg accgtcaatc cttctgtatt 2719861 tcgcaaaata tggccgccga tttcagcgtt catctggttt gtatctaatt caaattgctt 2719921 atacgctctc tttgtcgcga ctttaaacgt atcacctggt ttatactgat ctttgatagc 2719981 ctttagtgcg gttgccttaa tatcatcaag gcggctgtca cacttaattg ccaggctgaa 2720041 gctttgaatc ccaaacactt gctttaaatg aggaaaaaga gcctcaggat cctctccatt 2720101 taatgtaatc gtcatacgat ccctgttgga aaagtatttt aaattcggat agtctttcaa 2720161 aacgagtctg atgttttgtt ttaagcgctc aataaagctt tttctgtttt tgcctttggt 2720221 cgaaatttcc ccaaaacgaa ttaatatatg atcgtaattc atgttctacc tcatcatttc 2720281 ccttaatttt ttgatgccag gacgaagcgc gttcataaac ggttctgcca catcgcttgt 2720341 ctggctgtaa tttaaactga ttctgatgct gcttccggca atctgctctc ctttgcccat 2720401 ctctaagaga accttgctgg gcttatgttc ttttgccgag caagccgatg ttgtggagac 2720461 gaatatatcc tgttcctcaa gcatgtgtaa aagcacttcc gctttaatcc ccggtacaga 2720521 gaaattaata atgtgcggcg cgctattcat ttgaggcgtg ttgataacga cgccctcaat 2720581 ttcactcagc ctattcataa acaattcctt tacggcagtc atcgtgtcaa gccgtgtgtc 2720641 aaaatcagca gaggccagat taatggcctt ggcaagcgaa accgcaccag cagtatgttc 2720701 tgttccggcc cgtatgcctt tttgctgaga gcctcccgtt atgagcggaa taaggcgtgt 2720761 tccttctttt acaataagtg cgcctgtccc ctttaggccg tgaaatttat gccccgaaat 2720821 tgaacataga tcaatgccgg ccttttcaat tgccaagggc actttataga tgccctgcac 2720881 ataatcgacg tgaaacaaaa tgttcgaatg ctctttcagc acttctcctg ccgcttcaat 2720941 cggctgcacg gaaccgactt cattgttcac atgcatcatg ctgacaagca cggtatcggg 2721001 acggatggct gcttttagat cttcaataga aacaaatccg tcttcattca cagaaagata 2721061 agtgatatca aacccgaaca actctttcag ctgttctaac gattccgtaa cggatggatg 2721121 ttcaatagaa gtggcaatga tatgtttgcc tgtttttatc tttgacaaag ccgctccttt 2721181 taaagccgca ttattggctt ctgtggcgcc tgacgtaaat acaatatcat atttttttag 2721241 gcctaaggac cttttgattt gatttttggc tgcttgaagc agctgttccg tttcggctcc 2721301 atatcggtgc aaagatgaag gattgccaaa gtatcggctg ctcgtctgtt catatacgtt 2721361 caagacttca tcgtaaggct tcgtcgttga actattatct aaatatatca tcttttttac 2721421 tcctttatga aagcggtaca aggtatgata tttatgttac cataacaaaa tttaatagaa 2721481 aattacgaaa aactagtatt gacttctaat ttttttacca tataataaga tttgttcgtt 2721541 tcgtcatatt atctgacaat taattgacag aatattttaa cataattatt aggaggattt 2721601 ttttcatgaa acactcactg cctgtcaaag ataccattat tattggtttc atgctatttg 2721661 cgttattctt tggagcagga aatatgattt atccgccgga acttggacaa gcagccggac 2721721 acaacgtctg gaaggccatc ggcggatttt tactgacagg ggtaggcctg ccgcttctcg 2721781 gcattatcgc catcgcatta accggtaagg acgctaaagg ccttgctgac aaagcgcacc 2721841 ctgttttcgg cacaatcttt actgtcgtgc tttatttatc aatcggacca ttattcgcca 2721901 tcccgagaac aggaactgtt tcatatgaaa ttggcgctgt tccgtttttg actggtgtac 2721961 cagaaagact ttctttatta atatttacac ttatcttttt cggcgttacg tactatttag 2722021 cgttaaaccc atctaaggtt gtggatcgag tcggaaaaat tctgactccc atcaaattca 2722081 caattatttt aatcattgtt ctcaaagcca tcttcacgcc gatgggcgga ttgggcgccg 2722141 tgacagaagc atataaagga acaccggttt ttaaaggatt tttagaaggc tataaaacaa 2722201 tggacgcact tgcttcaatt gtatttggcg ttgtcgttgt aaatgctgta aaaagcaaag 2722261 gcgttacaca gtctaaagct cttgctgcag cctgcattaa agcaggtgtg attgccgctt 2722321 taggcctgac tttcatttat gtatcccttg cttatttagg tgcaacaagc acaaatgcca 2722381 ttggtcctgt tggtgaagga gctaaaattt tatctgcgtc ttcccattat ttattcggtt 2722441 cattgggcaa catcgtactc ggagcagcga ttacagtcgc atgtttaaca acaagcatcg 2722501 gccttgtcac atcttgcggc caatattttt caaaacttat tccggcatta tcatataaaa 2722561 ttgtcgttac gattgtcacg ttattcagct tgatcattgc gaatttcgga ctcgcgcaaa 2722621 ttatcgcgtt ttctgttcct attttatcag ctatctatcc gcttgccatt gtcattatcg 2722681 ttctttcctt catcgataag atctttaaag aaagacgcga agtgtacatc gcatgcttga 2722741 tcggtacagg acttttcagt attttagacg gtatcaaagc agccggtttt tcacttggat 2722801 ctttagatgt gtttctaaat gcgaatcttc ctctttacag cctcggcatc ggctgggtgc 2722861 ttccaggaat cgtcggagcg gttatcggct atgtgctgac cttattcatc ggaccatcca 2722921 aacagcttaa tgaaataagt taatgtcaca gaacgcctgc gttattgcgc aggcgttttg 2722981 taataaaaaa agagcctgct cattacactg cgggctcttt ttcatggtcg tgattatcta 2723041 agcggatatg tcagctttga ttttttcaac tgcacctggc gcagcctttt ctacagcggc 2723101 agcggcaatt tcataagagt cgtcataatc aaaagcataa aaacgtcttt ccgcttcttt 2723161 cagctgttca gataaaatat gattctggct tctgaaccgg tttccgaact gaatgatttt 2723221 ttcaatgagg atgacctgct cgacaagttc ctctgattcc cggcttgccc tgttgacgat 2723281 atcttctgct tgtttcaaat gggctccggc ttcttccata tttaatggaa gttcgtttag 2723341 ttgattgacc gtttcttgaa tatgatgatg cgcgttctcc agcatctctt gaatatggct 2723401 cggaatgcct ggaatgttgc tagtcttcag cagtcttgct gtctcagaaa ttgttttttt 2723461 caaattgctg agcgtctccc tcgcctgaag ctcttctttt ctcagcgctt gcagattttc 2723521 acgatactcg gcatgctctt ttttcacttc ttcaatttgc ttctctattg aagcaacttc 2723581 ttctactaaa agtgagtagg cgacatgctc tgcatcaagc ttatctttaa cggatgatag 2723641 cagctttcca atttcatcaa ggcgcttttc aaaagcctgc tgtttgccga gctcaccggc 2723701 tgtcagcctg tagctttcct tcaccagctc agtttccgct ttcgtatgct ctttctcttc 2723761 tttaagcttg tcgtaagcaa taatcaattc aggcattttg cttagtacgg attgaccggc 2723821 ttcaacttcg ccctccagct gctgataaac agattgaata ttttcgtcaa tgagctgcag 2723881 gattgcggac gcttcatcaa tatccagttc agtcatcagg acatgttccg ctcgtttcag 2723941 ctggtttgac agattttcta attccttatc aagctggata tgctcaagct tgtacccttt 2724001 ttctttcatt tcgccatagc catccttgag ctttgcaatc tgtccgggca ccgtctgttt 2724061 acagtcagct aacagcttcg gcacatcatc tatgtatgac tgaagccgtt caagattgcg 2724121 gtcctgctca agcagtactt ttcgtgcagt aatatagttt ccgccttctg tttcttcttc 2724181 aaattgtttg atgccgctcc aaatttcgtc cagatccttt tcaaggctgt cataaagctc 2724241 cccgtaaagg tggctgtaag ccagcaggtt ttttcgagat ttcgaatagc gctccctcac 2724301 ctgttcaatc tcttcacggc tcttttcctc acttgtgaca agatcgctga tttcccgaag 2724361 aatcttttca atgcttgatt cagccgctgt cagcaggtcg tcgatatgaa cgagcacttg 2724421 attggccttt ttaaaccggt atttgtctgc attttcctcg gcatcataaa ggagctcttc 2724481 aactttcggc atgtgggctg tgacaatctc atcccattct tcacgccact tctcaaagaa 2724541 ctcttctgtc tgacccgtca tttttaaatg ttttatttta gacatttctt ccacgatcga 2724601 ccgattcaga atttcaatct tccacgattc cagccggtcg atttcggcgt agattttttt 2724661 cctgaaaaag tagcctgccg caaacagcgc aagcagtaca attaataatc caatgacaaa 2724721 ctccataatg agcccccttg ctgtttacct taatctgtca gggtgtttta tttattcaga 2724781 aagatttcag gatatgtatt gagaaaaact gtcgttttca ttgttattat gataccatgt 2724841 aacaaacatt ttttgaccag aaatcaaaaa ctttttgtgc aaaatcggca ggatttgact 2724901 attttttcat ggggtgacat caatgcaaaa gcgagacgga catattcaca caccattttg 2724961 ccctcacggc tccaatgaca cactcagaca atatgcagaa gaagccttaa aaaaagggtt 2725021 cgaatcgatt acttttaccg aacacgcccc attgccgcca tcttttaccg atcccacgcc 2725081 gctgaaagac agcgcgatgg cgcaagcttc tttggaacgc tatattcatg aaatttccgg 2725141 attaaaaaaa gaatatcgcg gacagcttag catacggaca gggcttgaag tcgattatat 2725201 cgctgaattt gaagacgaaa ttacattatt cctagacaca tacgggccat atttagatga 2725261 cagcatctta tccgttcatt ttttgcgcac agactcttcc tatctatgcc ttgattatga 2725321 cgagcatacc ttcaaagagc tgatttcagc ctgcggaagc attgaagcgg tatatgaaca 2725381 atattaccgg agtatctatt cttccattgt agcatctctc ggcgtttata agccaaaaag 2725441 agtcggtcac atcacactcg tccaaaaatt catcaagctg tttccataca gcatgtcaga 2725501 gcatattcgc ggcctcgttt ctctgtgcct gaatgccatt gaagaaaacg gaatggagct 2725561 cgacttcaat acttccggct taagaaaaac ttacgctggc ggtatttata tcgaggattg 2725621 gatgctgaat gaagcgaagc aaaagaagat cccgcttgtg tttgggtctg atgcccatca 2725681 agcgggagat gtcggatatg cgtatgaggc gtttttggaa cggtgctagt tggtgagcgc 2725741 cacgtctcct gtccggaaga cgcttctgat ccaaatcttg atttcttcaa aatacatttt 2725801 ataaaaatac ggctcgtgcg gctgcatgta gagtacttct gaaatatatt gaggctggag 2725861 atagggcatc atcaagagag attttaattg gagaataaaa tgaggcagcg gcagcgttaa 2725921 atattcacgc tgtttttctc cttcctcaat gatcagctgg aagatatact tttccttcat 2725981 tagatatgtc gacataattt ccctgattaa tgtggagtca attgtgactt cccggtagac 2726041 aaaacgagtt aattgacgat gattatgctg ataggataaa atatcgaaaa ccaattgaag 2726101 aagctgttcc tgcgtgcttt gagtagagat attgcttgcc gctgtttcaa gcgttttgct 2726161 gtagccttcg taaaactctg aaactaagtg ttccatcaag cctcctttgc ctttaaaata 2726221 gtaggagatg tgcgcaacat ttacatcagc tgactttgcg atttcacgga cagacgtgcc 2726281 agaaaatcct ttttggttaa aaagcatgac agcagattca ataattttgt ctttggtgct 2726341 tactttcata cggctcactc cttcctcttg atactattca agcagaaagc cgctgttcct 2726401 gtaagaactt atcgacaaat gccggcagaa aagccggaac tttgttttat attatagaaa 2726461 aagtgagggt tttccatgtt ccatgtcgaa aaacaatctg gagataaaga aaaagactat 2726521 cagcttctgc taaaacagct cgaagccatg accgaagacg aaacagacca aatagctaac 2726581 tatgcaaatg cctcagcact gctgtatcat tcgctgcctg aagtcaactg ggcgggtttc 2726641 tattttgcca aagaagagga tggacagctt gtgttaggtc cgttccaagg cctgccggca 2726701 tgtgttcgga ttcctttcgg cagaggggtt tgcggcacag cgtacgcaaa cggaaaagtg 2726761 gaacgtattg aggatgtaaa cgcgtttccg ggacatatcg cctgcgatgc agcgtctcaa 2726821 tcagaaattg tgcttccgat tcgtgtagac ggaaaaattg tcggcgtctt ggacatcgac 2726881 agcccagtga aaaaccgttt cgacgaaatt gatgaaaaat acttaactca atttgccgaa 2726941 acgctagaaa aagcgttagc gcagtaatat aaaagcccaa aactgatatc gttttgggct 2727001 ttttttattt tattgagtca tgaatcatca agcggttttt cccgctccgt ttcgcgctgt 2727061 agagcgcttc atctgcctca tgcacaagct ctttcagcga cttttttgtt tctgtcgtcc 2727121 agcaggagat accgcaggaa atggttacct cgggtttcgt attttttctg accgcgtaaa 2727181 ccagtcgctc ggtaatccgt ttccccactg caaccggcac atttggcaaa taaatcgcca 2727241 gctcctctcc tccccagcgg gcaccgacat catgctttcg gatgttgctt ttaatcactg 2727301 aagcgacttg aattaaaatc tcgtccccag tctgatggcc gtacgtatca tttacatttt 2727361 taaaattatc aatatcaaca agaataaaaa cacccttttg atggattttc atgctgtatt 2727421 gaattttttc atctaaatac gctcgtgaat acagttcagt cagctgatct gttttcacga 2727481 gatgctcaag gcggtcgcga agcattgaat tggttacagc cagtgtcgcg tgatgaatca 2727541 gcgcctgaaa cagcttgtac atttcaaatg taaaagcgta cagctcctgt ttcaataaaa 2727601 ccgcaaagcc taaaagccgg tcgttttgaa tcatcggagc agccatcagc gagccgtacc 2727661 ccgccttccc aaaaacagac tggccattcc cgatgaaaac ccctttttca ccttcataca 2727721 gcttttcttt cagctcatta taaaaatctg acggcttcgc ttctttaaaa aatgctgtgc 2727781 tgcctgggag caatgttagg ttttcaaaat ggtctatatg aaaaaatccc acttcttctg 2727841 cctgaaacga ttctgccatt ctcacagcca gatcattcat tgtatcagtc aatgtcagcc 2727901 gctgattcag gcgtcgtgat gtttcattaa tcaattccaa atttgcgatg cttgctttgg 2727961 attgttcgta gagctgggca ttttcaaacg cttttcccgc ggcgtttgct aacagcgaca 2728021 tttcatcaag gcaggcatca gtaagaaagc tgtcacccgt tccttcagcc ttcaacaccc 2728081 cgtatgtgcc ctgctgtcct ttgatcggaa tataggcgac agattcattt ttccgcaaaa 2728141 tgtctccgga caaatacact ttgagcgcaa aggaatcgga tttttcccct tccatataca 2728201 gctcttttgc aggaatccct aaacattggt cttgatcgtg cgatataaat aaagaaaact 2728261 caaaaagaga aaatgtgctt gtcaagcttt ctaaaagctg cttcagcaca tctgtctgat 2728321 caagcagtga atggaacagc tctgtcattt tgtatatctt tttttggtag atcgttttgt 2728381 tatagagtct ttcctgtttc atcgactggt ttaaaaatga agcaaccacg tccggaagcc 2728441 cttcaggaat ctcttcatcc tgcctgcacg caagatggaa acgcctgccg gagccgtcct 2728501 caatcagata acatgaagcg tttatttttg aagcggaaaa acgcgcttca ccatctgcca 2728561 gttttgtcac aaagtctgat ggtgacggtg taagcgaaac acaaagggtt gaaaaatagg 2728621 tttgaatagc cgaagtcagc catatgaaag agtcggtgaa tgtgactttt tcagatttgg 2728681 ttaataaaaa atcgagcata tgataatgaa aggcggataa ttgatcttta gtttgttcta 2728741 ccatgttttt atcacctaaa agtttaccac taatttttgt ttattatatc ataaacggtg 2728801 aagcaataat ggaggaatgg ttgacttcaa aacaaataaa ttatataatg acctttgtgt 2728861 gaaatattgc agcctttttg ttcagcttct atgttttcat tttgttcctt atcaataagg 2728921 tgtatcgtgt aactctctgc tgctggagcg aggatacatg aaaacaaaat gtgcatggtc 2728981 gaatagagca gacggttttt attttccaca aaaataaaac caaaggagga gtcacattat 2729041 ggctcgctat acaggtccat cttggaaact gtcccgccgt ctaggaatct ctcttagcgg 2729101 tacaggaaaa gaattagaaa aacgccctta cgctccaggt ccacacggcc caggacaacg 2729161 taaaaaatta tcagaatacg gtttgcaatt gcaagaaaag caaaagcttc gtcacatgta 2729221 cggtgtaaac gaacgtcaat tccgcacttt gtttgacaaa gctggcaaac tagctggtaa 2729281 acacggtgaa aacttcatga ttcttttaga ttctcgtctt gataacgttg tgtacaagct 2729341 aggtttagca cgtactcgcc gtcaagctcg ccaattggtt aaccacggtc acattcttgt 2729401 agacggaagc cgcgttgaca tcccgtctta cctagtgaaa cctggtcaaa caatcggtgt 2729461 tcgcgaaaaa tcaagaaacc tttctatcat caaagaatct gttgaagtga acaacttcgt 2729521 tcctgaatac cttactttcg acgctgaaaa gcttgaaggt actttcactc gtcttcctga 2729581 gcgttctgaa cttgctccgg aaattaacga agcgcttatc gttgagttct actctcgtta 2729641 atcgttttaa aaacccctgc cgctatgcgg tcggggtttt tttatcggct ttcgcctctt 2729701 gctggccaac actatcttgc gcctgctgct cccaatgatc ccgctgcagc cgttcttttg 2729761 caatcgtaca catgagattc acgctttagc gctcctttca tttaaaaggt ggtgattggt 2729821 cgtgtttgcc ctatctaata tactcttttc ctttcattcc tatgcggtaa acaaaaagat 2729881 cctttgcctt cagtggcaaa ggatcttttt cttatttata cgtcacaagg aagtattttt 2729941 tcttcccgcg gcgcagaaca gtaaattggt tttcgatgcg gtcttcacct gatagggtat 2730001 aatttatttc cgtctggcgt tcaccgttaa tgtaaacagc tccgttttgg atgtcttcac 2730061 gcgcttggcg tttagaagga gataatttag attgcaccaa cacatctaca agtgaaagct 2730121 cttgggtgct gtcaacttcc atagaaggaa catctttaaa gcctactttt acgtcttgag 2730181 cagaaagctc tttaatattg ccgctgaaca gcgcttggga gatgttgatg gcttgctcca 2730241 gcgcctcgcg tccgtgaaca agtgatgtca cttcttctgc caggcgtttt tgcgcttcac 2730301 gtttttctgg cgccgtttct gttttttcag cgtatgcttc aatttcctct tttgaaagga 2730361 acgtgaagta tttcaagtat ttgacaacgt cacggtcgtc tgtgttgatc cagaattgat 2730421 agaattcata tggcgatgtt ttttctttat caagccagat cgcgccgcct tccgtttttc 2730481 cgaacttcgt gccgtctgct tttgtgacaa gcggaatcgt taggccaaac gcttttgctc 2730541 cttcttcttc tgattttctg atcagttcaa gacccgctgt gatgttgccc cactgatcgc 2730601 ttccgccgat ttgcagttta cagtttttgt ctctgtaaag atttaagaaa tcataagatt 2730661 gaagaatcat gtagctgaat tccgtgtacg agatgccgga ttcaattctt gagctgaccg 2730721 tatcttttgc cagcatgtaa ttgatgccga aatttttacc aacgtcacga aggaaatcga 2730781 tcacattcat tttgccgatc cagtcaaagt tgttcgcgat gacagctggg ttttctgctg 2730841 cttcaaaatc tagaaatctg gacagctggt ttttgatttt ttgggaccat tcggatacga 2730901 tgtcagcagt gtttaatgta cgctctgctt tttttccgct tggatcaccg atgaggcccg 2730961 tcgcgccgcc cacaagcgca atcggatgat gccctgcaag ctgaaaacgg cgaagtgtta 2731021 aaataggcag caggtgtccg atatgcaagc tgtctgctgt agggtcaaag cctgagtaca 2731081 agcggatttt ttcttcattc agctgtttat ttaacccttc ttcatctgtc atttgctgaa 2731141 tcaatccgcg gaaggataag tcttcaagta agttagtcat aagataaagc tcctttttta 2731201 attaaaataa aaaacgcccc ttcgtttaca cgaagggacg attgattatc gcggtaccac 2731261 cctactaata agagaatgca aacattcgtc ttatcacttt gcctgataac ggatcaggtc 2731321 cgttctttca ctactgaaag cctggccggc tttgtttgca aaagcggttc atgagtgtat 2731381 tcgatatatc cgtctgtgct gattttcacc ggccatcagc tctctggaac gtaaggatat 2731441 tctacttgtc tcaatcttta ccttttcata tgaagctata tcatttttaa cataaataaa 2731501 atcctgtgtc aacgccgcct tttaatcctc cattgttgac agatctccag ccggcagatt 2731561 aagctcccat gccttcagca cgcgcctcat gatctttccg cttctggttt tcggaagctt 2731621 atctttaaat tcgatctcac gcggagccgc atgggctgca agaccctgct ttacaaatag 2731681 gcggatctct tctttcagtt tatcagacgg ctcaaatcct tccctgagtg caataaaggc 2731741 tttaatgatt tctccacgca ccgggtcagg ctttccgata acgcctgctt ctgcaatagc 2731801 cggatgttcg acaagcttgc tttccacttc aaatgggccg acgcgctcac cggaggtcat 2731861 gatgacgtca tcaactctgc cttggaacca aaagtatccc tcttcatcca tgtaagcaga 2731921 atccccagac acataccagc cgcccggcat gaaatacgat tcatactttt cagggttatt 2731981 ccaaatggta tgcatcatgg aaggccagcc ctttttgatg gcgagattgc ccattcggta 2732041 cggcggtagc tcgttgcctt gattgtcaac gatcgctgcc tccactcctg gaatcggctt 2732101 acccattgaa cccggtttaa tatccatgca aggatagttg cagatgagct gactgcccgt 2732161 ttcggtcatc caccaggtat catggattcg tttgttaaaa actttatgtc cccatctgat 2732221 gacttccgga tttagcggct caccgacact gagcacatgc cggagtgaag ttagatcata 2732281 tttcgcagcc atttcatctc ccgctcccat cagcatccga aaagctgtcg gcgcgctgta 2732341 ccagacattg acgccaagct gttcaatcgt tccataccag ctttccgggc tgaaacgtcc 2732401 gccgacgatg acatttgtcg ctccgttcag ccacggtgca aaaatgccgt ataccgtacc 2732461 tgtcacccag cctggatcag ccgtgcacca ataaatgtct tcttccttta aatcaaggac 2732521 ccactttcct gtttgatatt gctgaatcat cgcttcatgg acatgcaaca cgccctttgg 2732581 cgtaccagtg gaacctgatg tatagtgaag cagaaagccg tcttttttat ccatccattc 2732641 gatatccaat cttgtgcttt cctgtttcgc tgcttcatca taattgatga tattcgtgcc 2732701 gctctcagcc tctcccccga ctacgaagac atgctgcaag tgaggcagtt tgtctaccgg 2732761 tattctctcc agcagctcag gcgttgtgac aacaaccttt gcctcactgt tttcaagccg 2732821 gtctttcacc gctccctcca taaatgcttc gaacagcggc ccggcgatgg cgccaatttt 2732881 gattgcgcca agcataataa aataaagctc gggtgatctc ggcataaaaa taaaaacgcg 2732941 gtcccctttt tccacatttc cataccgtct cagcacattc ccggctctgt ttgattcttc 2733001 cttcatttct ttaaatgtgt atttttcatc cctttttgcg tctttataat aaagcgctac 2733061 tttgtttttt cgaaacgatt cggcatggcg gtcaatcgct tcatacgccg cattcagttt 2733121 ccctgtctca tgccaagaga aatgtttctc tgcctcggcc caatcaaaat gccggtacgt 2733181 ttcttcatag ttttttaagt tatgatcccc ctctattgct ggtaacgctt tcaagttcat 2733241 gcccaaacat ccccctttgc tgaagttgtc acaattatta tagtatatat tcatattctt 2733301 ctcaattttt aaaatataaa ccatgttgaa aacgctttat aatttggtat tcttaaagaa 2733361 ggcatgtatt tttgataaga attgatggga cggtgaatta gtggaacatc ataaaacata 2733421 ccattcagca aacatcaaaa cagcaaccgg ctctttactg atagaagggc ctgtctctcc 2733481 agaggatttg gcaggttatg agtttcataa agatttaacc gcatttcgcc cgcctcgcga 2733541 gcagcatgaa gcgctagtcg acattgcagg ccttcccgaa gggcgcatta ttattgccag 2733601 agacggccga accattgtcg gctatgtcac gtatttatat cctgacccgc tcgaaagatg 2733661 gtctgaagga aatatggagg atttgattga gctcggagcc atcgaagtag cgccggacta 2733721 tcggggatgc gctgtcggaa agacgctcct gaccgtcagc atgatggatg aacaaatgga 2733781 aaactacatt gtgatgacga cagaatatta ctggcattgg gatttaaaag ggatgaaaaa 2733841 agatgtgtgg gaatacagaa agatcatgga aaagatgatg aatgcaggcg gattggtctg 2733901 gtttgcaacg gatgagccgg agatcagctc ccaccctgca aactgtctga tggcccgcat 2733961 tggaaaaaac gtcagccaag aatcaattga gcaatttgac aggctccgtt tttatcatcg 2734021 ttatatgtat taactgacac tgacaaaggg gaaaaaataa tgattgttga gcaaatcatg 2734081 aaaagagatg tcattacatt aacgaagacg gatacgcttg aaacagcaat atgcaaactg 2734141 aaggaattcc atatcaggca tctgcctgtt gtagatgaag aacgacacgt gatcggcatg 2734201 attacagaca gggacatgaa acaggccagc ccgagtattt ttgaagaaaa caaacgaagc 2734261 ctatttctca cacgaagcgt agattcaatt atgaaaaagg atgttgtctg cgcccacccg 2734321 ttagattttg tcgaagaaat atcagccgtg ttctacgagc atggcatcgg ctgcctacca 2734381 gtggtacacc atcaaaaatt aataggcatt ttaacaaaaa ccgatttgct gcggacgttt 2734441 gtcaaattga caggcgctga ccagccgggc tcgcaaattg agataaaagt aaacgacatc 2734501 accaaaagcc tcgctgagat cagcagtctt tgccaagacc ttcaagtgaa aatattaagc 2734561 gtgcttgttt atccgcatga cgatcccggt gtaaaagtgc ttgtcttccg tgtaaaaacg 2734621 atgaatccgc tgccgttttt gcaggcatta caaagaaatg gacaccacgt cgtatggccg 2734681 tcagagcaaa gggatctgct atgagagaca gtgtatttat ctattctcca tcctaccaaa 2734741 cctatatgtt tcatcaggag catcccttta atcagcagcg ggttctgtta acatatgatt 2734801 tgcttaagac gatcaatgcc tttgatgatg gagacattgt cacccccaga ctcgcttcag 2734861 aagaggagct ttcccttgtc cacacggacg attacattca ggccgtaaag cttgcgggcg 2734921 ccggaaagct ccccgctgaa gaaggagaaa gctacgggct cggcactgaa gacacacccg 2734981 tctttgccgg catgcacgaa gcggcatcac tcttggtcgg cggcacttta acggccgcag 2735041 actgggtcat gtcaggacaa gccctgcatg cggcaaacct tggcggaggg cttcatcacg 2735101 gctttcgcgg gagagcatca ggattctgca tatacaacga cagcgctgtg gctattcaat 2735161 atatccagaa aaaatatagc gccagagtgc tttatattga tacggacgcc caccacgggg 2735221 acggtgtgca atttacattt tacgataatc ctgacgtatg cacgctgtcc attcatgaaa 2735281 caggaaggta tttattccct ggaaccggtc agatccaaga aaaaggaagc ggaaaaggat 2735341 atggctattc ctttaatatt ccgcttgacg cttttacaga ggatgattct tttcttgagg 2735401 cttaccggac agcagcttca gaagtcgccg cgtatttcga gcccgatgtc attatcagcc 2735461 aaaacggcgc cgatgcccat tactacgacc cgctgacgca tttatcagca acaatcaata 2735521 tatacgaaga aatcccccgt cttgcacaca ctttggctca tcaatattgc ggagggaaat 2735581 ggattgcagt cggaggcggc ggatatgata tttggcgtgt cgtgccccgc gcctgggcca 2735641 gaatatggct tgaaatgaag ggaattgacc cgggtcacga gatcccgccg gaatggattg 2735701 ttaaatggca aaaacaatgc cccgtggccc ttccgtcgag ctggagcgat ccggctgatt 2735761 tatatcctcc gattccccgc aagcctgaaa ttacagaaaa aaatgcccaa actgtcagca 2735821 aagcattata tgcgatacgt tctgaacagc aaagaacaaa gtaaaaaacg acctttacga 2735881 agaggtcgtt tttgattttt taatcactat ttccacacgc cgattttcct tcatgtgttc 2735941 atttgtcttg ttatccttta ctggctttgt atccgcataa ccgacagcaa taaagcgctt 2736001 ggagggaagc ttctctttag acgtgaagta ttgaatcact ccacttgccc gtgctgctga 2736061 tagctcccag ttcgacgggt atcggtatgt cgaaatgttt cggctgtctg tatgtccctc 2736121 aacctgaatg tcatttggaa ttgtttgaag aagaacggca atttggtgaa gaagtgtttc 2736181 ggcatttttc agcacctttg cctcacctgt atcaaacagc acagcctcct gaagaacgag 2736241 cacgacaccg cgttcatccc gtttggctgt catttgggcc ttcaaatgat tgtcttttat 2736301 atatgtattt actttcttga gaagctgatc ctgctgatcc tcttgcttct tcgtatcaga 2736361 tggggatgta ttcttttttt ctatggatgt ttggtccggc tgaagcccgt tgccttcctt 2736421 ctggatcgag tccactgccg ctttgaattt ttgcagatcg atttgggaca tcgaaaagag 2736481 taaaataaag aacacaagga tcaaggtgat cagatctgta aaggttacca tccagctgga 2736541 tgaagattga ctgttttttc cgcttccatt ccttctttca aaacgttctc ttctaagctt 2736601 catgtacaga tccctttttt gtttttactt gttttggctg cttctgccat tcttcccgtg 2736661 agctgaaaac gaccagctgg ctttcaaggt tgcgcgggtt ttttccggat tgaacaccga 2736721 taatcccttc caccattacc tgcttgatga aaatttcact ttctgttttc tcttcaagct 2736781 tagccgcgat cgggttgaag accatatttg ccagtaatga accatataaa gtcgtcagaa 2736841 gcgcaatggc catgtttggt ccgagcatat gcgggtcgtt taagtttttg agcatcagca 2736901 caagcccgac gagtgttccg atcattcccc atgccggagc gaattctccc gctttttcaa 2736961 aaactcgccg cccttttcgg tgccgttcct ccattgctgc gatttctgaa tccatgacga 2737021 gccgaatcgt ttcttcatcc cagccgtcaa tcgctaaaag cagccctttt ttcaagaatg 2737081 gatctttgat ttcccgagcc tgatcatcca atgataaaag cccgtgtttt cgcgcgtgat 2737141 cggaaaggga aacaaaggtt ttcacaagat ctttcacatt gtcttcctgg cggatgaatg 2737201 cctgctttaa cacagagggc gcttttttca gctcacttgg cggaaaactg ataaaaacag 2737261 cggcgcaaag tccccctgtt acgatgaaga aagaggtcag atcaagaaaa gagcggaaac 2737321 cgcttactcc cgatcctgaa ataatcccga taacaataat aatcgttcct aacacaaatc 2737381 caacaggtgt aagataatca aaacgtttca tcatttctcc ccatgaaaaa agcaagaatt 2737441 caccataaag gtgaagcttg ctctttgttt ttcttatgac ttggttgact ttctaagctc 2737501 tatacggtgc ggcagttcga cgatatgctc ttcaaccggc tctttattca tgagcttcgt 2737561 cagcagtctc atcgcaacgg cgccgatatc atatgtcggc tgaacaactg ttgaaagctg 2737621 aggacgaacc atgaggctta atcttgtatt atcaaaaccg ataatgtcga gatcctccgg 2737681 aatggataag ccctgatcct gagcggcatg gataatgccg agtgccattt catcagttgc 2737741 agaaagaatg gctgtcggtt ttttatccag gctcatcaga tgctgcagtg cttcgagtcc 2737801 ggaatcatat gtgtaatccc cttcagctac aaattgttca ttaaacggaa ggttcgcttc 2737861 ttcaagcgca cgtttgtagc cttggagttt tttcgaacgg ttgatcggtt ctgccattgg 2737921 tccggaaacg aacgcgatgt ctgtatgtcc tttatcaacc aaaagcttca cggcatcata 2737981 aatcgcctgt tcgtaatcga tagcgactga cggtgtttcc tcctgctctt ctacagaagc 2738041 ggcaagtaca atcggcactg gagaacgctt aaattccgcc acatgctcgt ccgtaatgtt 2738101 tccgcccata aacacgatgc cgtccacttg tttgccgagc attgtgttta acaagtgcag 2738161 ctctttctcc atgttttggt cagagttgct caaaataata ttgtatttat acattgtcgc 2738221 gatatcttca attccgcgcg caagctctga atagaaaatg cttgagatat cgggaatgat 2738281 gacacctaca gttgttgttt ttttacttgc cagccctctt gccaccgcgt ttggacggta 2738341 accgagacgt tcaatggctt ccaagacttt tttcctcgtt gtcggtttta cattcgggtt 2738401 gccgttcacg acacgggaaa cggttgccat gcttacatta gcttctctcg ctacatcgta 2738461 gatcgtaata ttgctcatcc taaaaccact ccttttactg gatacactta tccttatcta 2738521 tagcataaac actttatgta gagaaatgtc ataatgtccg aatttatgtc gtttatgatt 2738581 tgtaagcgta agtcagtagt gtacattatt tttcattatt catcaaattt aattacttct 2738641 catgaaatta tacacgtttt tatagatgat gaaaacgtat acttggtttt tataactaaa 2738701 taaacgagaa agcataaaaa aaggccgcag gcgcggcctt ttggattgtt caattaagcg 2738761 ttgactttca ccattggctt cagttcattc agccattttt cgaattcagg aatcgccatt 2738821 tgctgagcag agtcagaaag tgcgactgac ggatcagggt gaacctcagc cattacgcca 2738881 tcagcaccga tcgctaaagc ggctttagct gtcggaagca agaggtcacg gcggcctgtt 2738941 gaatgcgtaa catcaacaaa gactggcaaa tgcgtttctt gtttcaaaat cggcacagct 2739001 gaaatatcca gcgtgtttct cgttgctgtt tcatatgttc tgattccgcg ctcacaaagg 2739061 ataatttggt catttccttg tgacatgatg tattcagcag cattgatgaa ttcagagatc 2739121 gttgcagcaa gaccgcgctt cagaagcact ggctttttca cggcgccggc cgctttcagc 2739181 aattcgaagt tttgcatgtt gcgcgctccg atttgaatga catcaatgta gtccagcgct 2739241 tcttcgatat gagccggagt tacgatttca ctgataaccg ccagatcaaa ttcatccgct 2739301 acacgtttta aaatttgaag gccttcaaca ccaagccctt ggaaatcgta tgggctcgta 2739361 cgaggcttaa aggctccacc gcgcaaaatt ttaatccctt gttttttcgc agctgcagcg 2739421 acttcagcta cctgctcata gctctctacc gcacatgggc cgacaatgaa tctttgctgg 2739481 ccgtctccga ttttttcgcc tttgatatca acaattgtat cttcaggttt tttcttgcgg 2739541 gagacaagca gcgctttgct gtgatcttct tcctgaagct ctaaaccggc tttgaatatc 2739601 tctttaaaaa tgtgctggat ggttgaattt tcgaacggcc cgtcattgtt ttcaatgata 2739661 ttgtttaaca ttgtgcgttc tctgacaggg tcaaatcggt tgacaccctg tgcttccttc 2739721 gctttaccga tctcttttac aacattgccg cgttcgttga ttaattttaa aatttgtagg 2739781 tttaattcgt ctgctttctg ccttaaaagc tctaactctg tgttgctcat ttttttcatc 2739841 ctttccctgc acattcattt tttattttgt agttatcatg catcttacta taagtaattc 2739901 caaatggaaa tactgaaata caaaaaattt tataaaaact ctactttatt acccaaacgc 2739961 ttttaagtga taaagtaatc tatgaagcta tcctacatga tgtgagggca atgttcaagg 2740021 gttttttaca aaaaaaagcg ccagatgata tctggacgct tttttctatg acaaatgctg 2740081 ctcaatagcg gcttctgtaa tttgtgaatg tgaggtatgc catttcactt caccgttctg 2740141 gatgatgaat atctgagggc tttcatgctt gaccccatat gtttctgcaa tgaaattgga 2740201 cagcggccgg gcttcttgta cttgaagata gtaagccggc acatcctcat gctgatttgc 2740261 aaaggcatca aactcatgaa atgctgcctg gctgatcggg catgtggtgc tgtgtttcaa 2740321 gaagacgaaa acgccttcct gttctgcaat ccgtttaaat tcttcctcag attgaataag 2740381 ctgtttagcc atgactcaag ctcttccttc cctgctcagc gattcaactg ctcagcctgt 2740441 ttttgtgcat ctttcagttc gtcttttaca tcttctttcg tctggaggac ttgatctttt 2740501 gtttcatcag ctgcctgcat cgcttcttcc ctcatatctt gcattgcagt cgatgaatcc 2740561 gttttgtcag atttggaacg gtctctcaaa tcctttacct tgttcatgat ctgtccagac 2740621 tgatccgcta caagctgtgt gatgttggaa gttttgtctt ttgcgatgct gacatattgc 2740681 gtgccttttt ccttcgcatc tgccgtcatt ttatcagttt tgtcccgtaa ggcaacagcc 2740741 tggctgccga gatcgtcgcg aagttctttg cctgatttag gcgctagaaa aagagctgta 2740801 gtggcaccga tgattccccc gattaaagtt ccgattaaaa aatctttact attaattcca 2740861 tctttgctca tcattattcc tcctcttagt atttttttct cttacagggc tgattttttc 2740921 ttttgcttcc atttctccca aatttccatt gctgcttgac tccaagtgac aacttgattg 2740981 atcttatctt gattctctct aactgatgcc gatacagacc ctgccgcttg tttcatggat 2741041 gtattgaact gctgtacaga agctcccact ccttgaacag catgaacgac cgtgttcagc 2741101 ttttctgatt tttcctgaat atcttcagcc aggcggttgg tcttatgtaa aagctcggct 2741161 gtttcagttg tgatgccctt catttgtccc tccagccctt caagagtgga tgcgacgttt 2741221 tttagtgtca gctgcagtga cttcaatgtt ttagacaagt agatcactaa tacgagaaat 2741281 gcaactgcga tgagtgcaac gctcaaataa agaataataa tcatctcaaa cctccttgct 2741341 gcaggatata ctgctgttta cccgttttct tcaatcataa acatgtgtac tgggctgtat 2741401 acatactatt ctccgttatg taagaaaatc ctttaataag ctttcccatc agataaataa 2741461 aaagcagtga gatcactgct ttttattatg ccatgacgtt ttcgtaggct ctcatatatt 2741521 tttggatatc tcctgctccc atgaagatga gaacggcttt atcatgagct tttaaaacag 2741581 atgtgtcatc ttcttcaatc agcttggcat tatgaatttt tccctggaga tcaccgatcg 2741641 tcagctttcc ggcattctca cgggctgagc cgaaaatatc gcataaatac acacagtcgg 2741701 cgccgctcag gctttctgca aattcgtcaa ggaactgctg cgtccgggta aatgtatgag 2741761 gctggaatac cgcgacaatt tcccgatcag gatacttctg tcttgccgcc tcgattgtca 2741821 cttttatttc tgtcggatga tgggcatagt catcaatcag cacttgatcc ccaagctgct 2741881 tctcattgaa tctgcgtttg acgcccccaa aggatttgag agcatgctta atgatgctgg 2741941 aatcaatttc ttcataatgg cataacgcaa tgaccgccaa tgagtttaat acattgtggt 2742001 ggccgtacgc aggaatataa aacgtatcat agaacgtatt gcggacaaag acatcaaaag 2742061 ttgtcccttc cgtgcttttt acgatgtttc tggcttgaaa atcattttct tcccccgtgc 2742121 cataatacac aaccgggacg ttcgcatgga ttttcggcag atgctcatcg tctccgcagg 2742181 caataatgcc tttgttgact tgaagagcca tctcttggaa agcgtcaaat acatcgtcaa 2742241 tgcttgagaa gtaatcaggg tgatcaaaat caatattcgt cataatcgca taatctggct 2742301 gatagcttaa gaaatggcgg cggtattcgc acgcttcaaa cacaaagtat tcgctgtttt 2742361 catttccctg gcctgttccg tctccgatta agaaagacgt cggttttgcg ttttggatca 2742421 cgtgagccag cagacccgta gtcgacgttt tgccgtgtgc gcccgtaacg gcaacactcg 2742481 tgaatttttt catgtagtcg cctaaaaact tatgataacg tatcaccgga attccctcag 2742541 acatcgcttt ttctatttca ggatgcgtgt ctgggaatgc gtttccggcg atgactgtca 2742601 tgccgggttt aatattttcc gcgctaaaag gaagaatcgt aatatttctt ttttcaagcg 2742661 ctgtttgcgt aaaaataaat ttttcgatat ccgatccttg gacagtatat ccattatcat 2742721 gaagtatttg ggcaagcgga ctcataccgg tcccttttat tccaacaaaa tgataaacag 2742781 tcataattgt acctccaaca aacgtctatc tgttccccag tatatgacgc tcatttcaat 2742841 ttgcgaccgc ggcggctgaa aagcctccct tagcggcgta ttttatatgt tttgttatgt 2742901 ttagtatcag gttatttctt tccgattaaa cccagatatc aagatttgtc tatgcacagc 2742961 tgctgtaaag cggcatagct gttaaatgct ctaaacacta tcataccatg tttggtgtga 2743021 aaatgaaccc atattattcg tttattaaat cacttgctgt gatcagcacc tctcgaggct 2743081 tgcttccttt tgcctcagag atcatgcctt ccgcttccat catgtcgatc agccttgccg 2743141 cacgattgta accgattctg aatcttcttt gcaggcttga agtgctcgca ctgttttgct 2743201 ctacaacaaa ctcacacgct tcgtaaaaca gttcgtcctc ttctttcagg gcagatcctt 2743261 gtcttacgag ctcttcttgt tcaaataaat aggtcggcgg catttggctt ctgacgtggg 2743321 aaacgacgcg gtcgatttcc cggtctgaca caaagttacc ttgcagacga accggttttc 2743381 ccgagccgtt ttccaaaaag agcatatccc cttttccgag aagcttttct gcaccggcta 2743441 tatcaataat tgttcgggaa tcaacctggc ttgagacaga aaaggcgatt ctcgttggga 2743501 tattcgcctt aatcagacct gtaatgacat cgactgacgg acgctgagtt gcgacgagaa 2743561 gatggatacc gcacgctctg gctttttggg cgatccgcgc aatgctttct tccacatcgt 2743621 ttggagccac catcatcaaa tctgcaagct catcaataat gacaactaaa tacggcagct 2743681 tttcacccat ttggtgttca gcggttaatt gattaaagcg gtcaatgtcg cggacacctg 2743741 aatgggcaaa aagctcatag cggcgctcca tttcctcaac gacccatttc aaagcagccg 2743801 tagccgcttt agcatcagta atgaccgggc tgacgaggtg aggaatttta ttgtaagggg 2743861 ccagctctac cattttcgga tcaatcagca gcacctttac ctcactcggg tcagctttat 2743921 aaagcaggct tactaatatt gtattgatgc atacgctttt tccggagcct gtagcgccgg 2743981 caatcaagcc atgcggcatt ttcttcaagt cgataacaac aggatttccc gaaatatcta 2744041 atcccagcgc agctgtgagc ggtgacttgc ttgtcctgaa agctgagctg cgaatcattt 2744101 ggcgcaaatc aaccaccttg ctcgtgcggt tcggcacttc aattccgatc gtgtttttcc 2744161 ccggaatcgg cgcttcaatc cgaatatctt tagctgagag actgagttta atatcatcgg 2744221 acaagttggt gattttattc acctttacac ccggttcagg atgcacttca aatctcgtga 2744281 cagacggacc ctgggttaca tggaccacat tggcgcggac attgaaattt ttcaaggtca 2744341 aatcaagaag ctgacgctgt tcttcgatcc acgcagtatc atcttgaacc tgcgctggcg 2744401 ggacatcaag cagtgcaaca ttcggaaata catagctgcc gcggcgctcc tctgcttttt 2744461 gctgtttatg cgtatctctt ttcagcatca tcacattaaa aggaacggat ggcccttttt 2744521 gagaagatgc gctttgttca gtccttttct cctgtacacc aggccttttt ttcggctctt 2744581 ctgaagcttc gcgaggtttg tctgcgcgaa tttcctgccg gttttcaaga gttgcagtag 2744641 acgatttgga accctgctcc atgtgttcag ttttctcaag ctctgtatgg ctgtctggct 2744701 gaacatctat cttcgtttcc tgagcctctc ccagggtgtc ataatgatta tttattatgc 2744761 tttctgatgg ctcttctgat tcttttgcca cagtttctgc ttgagccaga gcctctgatg 2744821 aatactcatg atcagtaaat aaaggctctt cctgacgaat gtccatttgt tcttcttgaa 2744881 cgaacgggga ctcagcacct tctgccgcgt tttcatgatg attgtatact gggctgtctg 2744941 acggctcttt tgctttttca tcctcagata ctgcctctgt ctgagattca ggagctgttt 2745001 gctcttcatc aagttcagcg gagaaaacag gctcttcaaa tttctctggc tgctgctccc 2745061 tttgttcttc ctcagccgtt gcaggctctt cgcggcctac ttcactgtct gaaagccctt 2745121 cagccgccgt atctgtgagc atctcaggcg gtgtttgctc ttcggcttgt tcagctggga 2745181 agaaaggctc ctctttttcc ggctgttgaa cgcctgactc aaatggcact ttgttacctg 2745241 acggctcggc tggccgtttc gccagcgcct catcatgctc cgtatccttt ctgtttaaaa 2745301 cgccagaagg ctgtttttca aattgggtat ccgggaagaa aggactttct attttggaat 2745361 gcgcctgtgt gtctgaagca ggatagccgc gttcacgttc gatctcttct gacagcagtg 2745421 ttaccttctc ttttaccgat ttatccggtt cgttcaatgt ttcagaaggc tttttcggca 2745481 catccttttt aacagatggt ttttgattga atccatagac aggcgaaggg atatttgtcg 2745541 gtttaaacgg tttcttcgcc ggctctgctg cttgatatgt atgctgctct tcttcatttc 2745601 tgggacgctc tctgtaaggt gcagcacttg gacgaggcgc ggatttcggt tcgtccgatg 2745661 gtgtgcggcg ccttctcagg tcatgatttt tgtatccgtc aggcacgact ggaaaacgga 2745721 atttgccttt tggatattca taatatattt taggatcttc caatcttttt aattgtcctt 2745781 caggatgatg tacttcttgt tgctgcggaa tttgagcggg ttttgtctcc cgttcagcat 2745841 cctcttcgct ttcgcctaaa aacaaatcaa aaaatttatg aagccaactc ataatttatc 2745901 tctaactccc ttatagtttt ctgggacggt ttttagtata ccactgctgg tcggcccaga 2745961 aaagattaag ctatcagcag aaacaaagcc gctaaacaag ggcttagcgg cttttcacat 2746021 gattcgtttt ttttggcgga tttatgggag tctaaaactg aaatgcgtct cccgcctcat 2746081 agtctccttc taacacaagg attccttttt cagcaggggc atccggcaaa tcaagctctt 2746141 tcgctgagca gatcatcccg cttgacggaa cgccacgaag ctctgcatcc ttaatgacaa 2746201 gtccgctagg catcacagca ccgactttgg caacgacaac tttttggcct tggtcaacgt 2746261 taggcgcgcc gcagacgatc tgaagcgttt cttctcctac gttgacttta catacgctta 2746321 atttatccgc attcggatgt ttttcttttg attctacata acccacaaca aacttcggag 2746381 ataaatcaac gactaatgtt tcttcaacgc cgtttctgtt taaaatctca ttcacatctt 2746441 gcacgaatgt ttctgagagc gcaacagggc cgttttcatc aatggtcaag taagaagacg 2746501 cattgaaaat gttgaagccc gttgtttctt ttgtttcgtt attgaaaatt ttgacgacgt 2746561 cgccgtgttt ttcatagcct aattgttcgc gtgtcacatc ttgaagagag atcaggagcg 2746621 tgtctcccac accttcttta ttataaaaag cgttcataag taaaaatcct ttctaatcct 2746681 ttttcggacg gcttttcgcc aggataaaca ccggttccag ctttccttca ttgtacaaaa 2746741 atgatagggc ggtaatcggg acggtgccgc ctgcaaagaa gctcatcgac atttgtccta 2746801 gaatatcata ccccgattca ttccggatgt cagcaagaat caaaacgtcc tgatgaggaa 2746861 cagagatcgc cagctcacct tctgcatgct gcttatactc atttaagatc gcttcgttca 2746921 aaatccggct tgcgtcgtat ccgtcgtttg ccctgaagaa ataaaagtaa ttgccggcaa 2746981 ccgtatcctc tttgacaacc gtcggcaggg aacggagatt aaatgcggcc gtctctctga 2747041 tccgctcttt tgtccagttt tctttctcaa gcatgcgctg gtcaattaaa cggtaggttt 2747101 tcccgagatc tagcgcgtaa taaattcttg tctctgcggt atgatcgtca taaatgagcg 2747161 ggatatcttc gctggacttg tccgggaagg aagtcgagcg gatgaccgga taaatgcgag 2747221 tttctttccc ggtcatttcc tgagccttcc cttccattgc cgtcatcgct tcggagacat 2747281 agtacacgat ctcatcaatg gcttcgtctt ttttcagttc ccattttgca ataatcggcg 2747341 gcaaatcgag tgtaatccct tttttagtcg tttgatcctc aacacggagg gtgtcttttt 2747401 ctctgtcaaa cagaaaggag cgattctcgt gctgaaggcg ctgcttcagt atatctgaca 2747461 gcttccttga ggtcattttc aaaccgatgt cctcctttac gctttagcga gagagtctgt 2747521 taaaaactgt tcaatttctt cttttgtttt gcggtctttg ctcacaaaac gatttacttc 2747581 ttttccttca ttaaacacca caaagcttgg gattccgtaa atttcccact ctgcacatgt 2747641 atcaatgaat ttgtcacggt ctacgtagta gtaggtgaat tcagggaaat tcgcttccag 2747701 ttcaggcagg aaaggctcta caaaacggca atccgggcac caatcggccg aaaacataaa 2747761 tacagaccaa tcatccttta ccgctttttc cagctcttga gttgattcaa tttttttcat 2747821 ttcatatccc tccagttgtt tatgttctta catgtttttt atcgatactc gtccatttgg 2747881 atcataccaa actgcttgag gcaaaaccac ttatatgcaa cgaatgaata tgtaagattg 2747941 gctttcccat tatcattatc atattttatt tgcattatca agctcgtttc gtttaacatc 2748001 gtgtacatga gggtgaaatt tacagatgga tatacataag gagggatttt tattatggag 2748061 tttatcgtct atttagcagg agaaatccac agcaattggc gcgaggaaat taaagaaaaa 2748121 acaaaatcac tgaagctccc gattacgttt gttggcccga tggagaatca tgaccgctca 2748181 gacaatattg gtgaagaaat tatgggcgta cagccaaatg ccgttttaaa ggatgacaaa 2748241 gcctctgaca tcaacaactt cagaaccgcc gtcctgatga ataaagcaga ctttgtgatc 2748301 gccctgtttg gcgaaaagta caaacagtgg aacacggcaa tggatgcatc atatgcgatc 2748361 gcaaaaggaa aacccctgat tatcatccgg ccggaatcgc tccaccatcc tttaaaagag 2748421 ctttccaata aagcgaatat tacggttgaa accgttaacc aagccattaa ggccctttcc 2748481 tatctatttg aaacagaata agaaaaaagc ttgtcgatcc gggcttactg ctcgttcaac 2748541 aagcttttat gaaacctaca tattttcttt aatcgcatcc actgtctgct tatcgcaggc 2748601 tgttacaagt ttgatgagca tttctttagc agcagcataa tcatcaatat gaatgatagt 2748661 agcgtttgta tgaatatagc gggaacatat tccgataacc gctgacggca caccgctgtt 2748721 cgaaatatga accttgcctg cgtctgttcc cccgccggat acaaaatatt gatatggaat 2748781 atcatgcgtt tcagccatat caagaacgaa ttccctcatt ccgcgatgca tgactgtcgt 2748841 tctgtcaaga atgcgcagca aaaagccttt tccaagctgg ccgaattcat ttttgtctcc 2748901 gctcatatcg tttgccgggc tggcgtcaag ggcgaaaaac aagtccggtt taatcatatg 2748961 agaagccgtc tgcgcgcccc ttagccctac ttcttcctga accgttgcac ccgcatagag 2749021 tgtattcgga agctctttac cgtgtaattc cttcagaagt tcaatgctta agccgcatcc 2749081 atatctgtta tcccatgctt ttgataaaat tttcttttca ttcgccatcg tcgtaaacgg 2749141 acaaacaggc acgatctgct gtcccggtct aatgccgatt ttgatggcgt cttccttatc 2749201 atccgctcca atgtcgatca tcatgttttt gatatccatc ggtcggtttc gctgcgcatc 2749261 tgtcaataaa tgcggcggta tgcttgaaat cacacccgga accggcccgt tatctgtttg 2749321 aatttcaacc cgctgcgcaa gcaaaacttg gctccaccag cctccgagcg tctggaatct 2749381 gagcagcccg ttgtctgtaa tggatgtcac catgaagccg acttcgtcca tgtgcccggc 2749441 taccataatt ctcggtgcgt cctctgcgcc tcgtctgact ccgaaaacac ttcccagtct 2749501 gtcctgaacg atgtcatctg catatttggc tagctcctgc ttcataaaag cacgaacctg 2749561 atgctcattg cccggcgcgc cgggaagctg cgtcagtgtt tggaaaagcg ctttcgtttc 2749621 ttgattcatg ttttcccctc atttctatgt agtcctttta ttttattaga aacaatgaag 2749681 ttttccaagc actctgaccc aatctgctcg atcagccgcg tattgcttaa caggatttgg 2749741 ctgtttctgt ataatgaaaa gtacgatcaa ccaggaggtg ctttattttg aaattgcgtc 2749801 atcttctttt aggagcagga cttggaattt gtacggctgt cgttgtgaga caatatgtga 2749861 tgaagcctta tatttcttca gaaaaagcgc ttcgaattgt aaaatctgct tttaagcagc 2749921 ggggcccgat tgacggatca tggatttaca cccagccgga gccctacaat attaacggag 2749981 aaacggtaca ggtatacaaa accggcatta cacgatcagc tttcggagaa ttagaacagt 2750041 atgaagtcat ggtggatgcg aaaacgggag aaattgttga tgtcattgat acaatcgcct 2750101 cttaacaccg gacaagcaaa aaatagaagc cgctgcctat gcagcggctc ttttttatta 2750161 tatcgcgcga atcggtttgt ataccggata ccacatcgca tcctgcactg cctgtataat 2750221 gtcttcaggc tcttccgtag cgacgccttc cttcattgcg gtttttgcaa cttcaacagc 2750281 aacggttgcc gaaacagtgc gcaaatcttc aacttttgga agcatcggcg ccccaggcac 2750341 cccgacattg accatacctg cgattgcccg ggcacatgct tcaaacatgc cgtcggtaat 2750401 taattttgat tttgtaacaa tcgttccaag accgagacca gggaagacaa gcgcgttgtt 2750461 tgcctgcccg atatgatacg taactccgtt atattcaact ggcgggaacg ggcttcctgt 2750521 cgtgatcagc gcacggcctt ctgtccattc gattaaatcc tccggctttg cttcagaaag 2750581 agttgtcgga tttgacattg gcaaaatcgc cggccgtttc acatgtgacg ccatttcttt 2750641 tacaatttct tcagtgaaag cgccggaaac cgtagatgtg ccgatcagga tcgtcggttt 2750701 cgcctgccga accacttcaa gaagatcaat gcctccgccg tctccgttcc gctgataatc 2750761 cttcacttca tcagccgaac gggcatacgg cttttggaaa tcaagaagct gatccatatc 2750821 atctgttaac agcccgttcc tgtctatgca ccagaagcgc ttgtatgatt cttcttcact 2750881 cagtccctcg cgcaccaatg cttcccgcag ctgttcggca attccgattc ctgccgttcc 2750941 cgctccgaat ataacaactc tgtgatctct cagcggaact ttagacgctt ttgcacagga 2751001 taagactgcg gccaaagaaa cagcgccagt tccttggata tcatcattga aggtacacac 2751061 tttatcttta tagcgtttca aaatgcttcg cgcgtttttc gccccgaaat cctcccaatg 2751121 cagcaatgca ttcggaaatg tttctctcgc cagcgcaacg tagtcgtcaa taaattggtc 2751181 ataacgttcc ccgcgcactc tggaatgctg gttgccgaca taaagcgggt cgttcaagag 2751241 gctctcctga tttgtccccg catctaaaac aacagccagc actctgctcg gatcaatgcc 2751301 cgcagccgct gtataaaccg ccagcttgcc aatagaaatt gcgattcctc cgacgcccca 2751361 gtcaccgatt cctaaaattc cttccgcatc agttgcaaca attaaatcga tcgtatcgct 2751421 ttgatcttta tactgtttaa aagcttcttt cataccgtcc gggtcatcga ttgacagata 2751481 gagccctcgt ggttttctgt attcatggct gtatctctga attgccgttc cgactgtcgg 2751541 tgtgtagaca atcgggagca tttcccctaa atggtcattt aacaggcggt aaaacagcgt 2751601 ttcattccga tcgtgcagcg ccgttaaata gacatttttg ctcaaatcgt caggctgtgc 2751661 ggaatattgt tcatacgctc ttttcgcctg atcatcaatt gttaatacct tgggcggcag 2751721 aaagcctttt aaaccaagtt cttttctttc ttcctcagta aaagcaacac ctttgttcaa 2751781 aaaaggaaca gagagcactt caaggcctct taatgttgtt tgaatgtctc cttcgtttgt 2751841 tactctgaat tgtttcaccc tgcctcttcc tttctgagca taatagtact aggtttgcat 2751901 tattagccgg aaaacatgca gggtaaacat aaaaatatgc tatcgcttca ttcgcttaac 2751961 tgactttttg atgcttccgt cctcctccca ttgaagggcg cgatactcgg catcatggta 2752021 aaaaataaac caagcatctt tttctgctgc gaacgcctgc catttctgct tttgcgggat 2752081 agaggtcatc ggataatcat cgtaagccag cacccatagc ggattgcggt gggcatgtgt 2752141 cggcatcaga tctgccatat gtacggcagt ttcacccgca tcctcgcata tcaggacact 2752201 gtgtccgtcg ctatggcctc cggtgtgatg cattgtaata ccctctgtga tcgttaaggt 2752261 gtcttcaaag gttttgactt ggccagctac agcctcccaa ttttctttcc aatacgtatt 2752321 tttcgacctg atattcggat ggcgcatttc gtcccattca acagctgatg tataaatcac 2752381 tgcattcgga aagacagaga cgagccgttc accttcatat tccgttaaac cgcatgcatg 2752441 atcaaaatga aggtgtgtca ttgcgatcac atctatatcg gcaaccgtta atccgagtgc 2752501 agctaatgag ggtttcacat tcgactcttg tgtcacgcca tagtttcgtt tttgtttatc 2752561 agtcagcttg ccgtacccaa ttccggcgtc aatgatgata ttgagcccat ccttttgaat 2752621 caaaataggg tctgttctta gttcaatctg gtttttttca ttgactggat attttttaga 2752681 ccaaagcggc tttggcacaa cgccgaacat ggcgcctccg tccatatgcg tcacgcctcc 2752741 gtcaagccag gtcaacgtga tgtttccaat tttcattgtt tccattttca ccccccccta 2752801 tcatcatggt agcaaacggc ccataaaaaa aacagactcc tgtcagagtc tgtctttacg 2752861 ttctccattc aacctcagcc cgatagatcg gctggccgag tgcagagaat ttttcttcat 2752921 attctgtcat aatattgcct tccagattgc tgttatgcaa atcgagactg acgtatgtca 2752981 gcaggaggcc gtactcagag aagctcttca aagagtactc aaataaacct cggttgtccg 2753041 ttttaaaatg aatcgatccg cctttgccca ttacttcttc atattttttg aggaagtggg 2753101 aatatgtcag gcggcgtttt tcatgccgtt tcttcggcca aggatcagaa aagttcaagt 2753161 agacccgttt cacttccccc ggctcaaaca catccgtcag cgtgtccgca tctatattca 2753221 gaagctttac attctgcgct tcgctgtctt ttactttttg gacggctgtc acgatgacgc 2753281 ttttaaataa ctcaatacca atataattga tgtcgggatt ttgtttggcc ataccagaaa 2753341 taaattggcc ttttcctgta ccaacctcga tatggatcgg attgtcgttg ccaaacactg 2753401 tgttccattt ccctttataa tcagcaggat tgctgatggc aatatctgcg ttttcagcca 2753461 aaaagtcatc agcccaaggc ttgtggcgca ttctcatatg attgacacct ctatctatta 2753521 tttcgactaa caacatacca tgaattaaaa agacccgcaa gctcgttttt ccagtgtatc 2753581 tctcttaagg ccgagcgcat aaaaaaagag ggtcccgtct gctggaacac tcctttccca 2753641 tgtataaaaa cgctctgttt tgaacaattt aacccgtatg atactgaagg gatgtgtacc 2753701 gttatgggtt tacattatga gcatcaagtt catttattga aggatatatt gactgaccat 2753761 caattggact gctgcggaac agtcgcagag tacgagcagc ttgagcgtgt gattaaatca 2753821 ctgatggcaa acaccgagct tgattcaaat ttcaaaaacg tgcttgaaga tgtttaccgc 2753881 tacagccaat caggaatatc gtccaaatcc atcgactcac acatacaaga gcatcagaac 2753941 agcctgtctc aatgggtaga gcaaatggat tcgtattcct gattaatcaa caattcgttt 2754001 catgaggata tgcagctctt ccattgcatc atgaaattcc ttatcattgc cttttgcttt 2754061 atgccaggca atgaaagtaa ttgtttcaga taacacatac caagccattc gcaaccgaag 2754121 gctttctgtc agctctatgc cgtacatgct cagccagctc tcccaagctg gcttttcgac 2754181 gtagtggtac agcaaaggcc cgaggtccat cgccggatca gcgatcatgg cgccgtccca 2754241 gtcaattaaa tacagctggt tgtcttcaga caatagccag ttattatgat tgacatcaca 2754301 atggcaaacg actttctcac cgaaatgcac ttcatgcagg tgttcttcca aatacttgat 2754361 cccttcttga atcagcggcg aagattgctg cacagcaaat acagcctgct tcagctgaga 2754421 caaaagagcc cccgggttca gcggttcttt tccaagtctc ttcagcatgt ccagcaaggc 2754481 ttttgatgtg tgtattttac gaagcaattc agcaacgggc cgtccgctca tgtctttagg 2754541 cttcagctct ctgccggtca tccagtgctg ggccgtaatg acgtccccat tttccatccg 2754601 ttttgtccaa accagcttcg gaacaatgcc ttcggcggat aaaacagcta aaaaaggtga 2754661 gctattacgt tttaaaaaaa gctgctgccc gttatgtttc gcataatatg catctcctgt 2754721 agctcctccg gcggggaaga tctcccaatc gctacctagt aattgtccca accagttcat 2754781 atcaatgttc aacccatcat ttcttaaaat attttagaat taaggctaat cgtttctagt 2754841 ctatccagcg aatgcctttt tcgtacgaat cgtataaaaa taaaaaagac agctattgag 2754901 agtctcatat gctaatcaat agccgtcctt taaattttag cgctatagca caaacttcgt 2754961 caagcaaaac tcttaagatc tgatgctaaa tataagataa ccgttccgat gccgtttact 2755021 gcaaccgttt tcttgatttc tgttgggtct tcctgaaatc ctgatggatc acataaaagc 2755081 cgataaggta tgtcgtttgg cagcctccac tcgacggagt ctggactcgc gtgatggata 2755141 acaatgatat ctttccattc gtcaacctcg tcaagatcat aaagcctgta tgcgataagg 2755201 tgttctttta gcgtcaagca ttcaagatgg cgctggatgt ctgcagcgga cctaagacgg 2755261 aatgcaggat gcgcttttct cagcgagatc agcctgcgga tatagtgaac atcttctttg 2755321 aatgtttcac ggcgatccca gtcgagctgg ttgatgctgt cactggattg atagctgttt 2755381 tccactccct gcttcgtccg gaaaaattcc tggccgctgt gaataaacgg caccccttgg 2755441 gcaagcaaaa taatcgcggc tgcaagcctt tgcctgcttc gctttcggct gtcattttct 2755501 tgaggaagcg caaagctcat tttatcccaa aaggtgtgat tgtcgtgtga ttcgacataa 2755561 ttgatggact ggcttggttc cggaacaatc ggtgctaatg ccttccatcc ggaagacccg 2755621 gcaattccat gcatcacagc ttgtgctgat tcaccgttgc cgagcgcaaa ccctgttgcc 2755681 ttaaggtgaa aggtgttccc ttttacagcg tcacgaaaca tatcattaaa aaagccgatg 2755741 cccggcattc ttggcgcgtt cgccaaagca gctttctgtt catgcggcag cggtgtagcc 2755801 aggtcccacc cttctccaaa aagcaggatt ccgggctttg ccttagttgc tttctctttc 2755861 atataaagca cggtgtcaat atctaaaatc ccgaggagat caaagcggaa gccgtcaaca 2755921 ttgtattctt caagccaata gaccacgcaa tccgcaatga attttcttgc catccttctt 2755981 tctgatgcaa tatcattgcc aacgccggtg ccgtttgatg gcatcccaca ttcgtcgtgc 2756041 cggaaaaaat aaccgggcac tgtcttttca aagggggaat tctccctctt atacacatgg 2756101 ttaaaaacaa catccagaat gactcgcaga ccgtgctgat gcagggtatt gatcatttgt 2756161 ttcagctctg tttttctcgt ttgaggatca tgaggatttg aggcatagct tccctccggg 2756221 gcaaagaaat gaagcgggtt atatccccaa ttgtatgcat caagcggctt ctcttcatca 2756281 actccggcaa aatcattcac cggcagaagc tccacatgtg tcacaccaag ctcttttaca 2756341 tacgctaatc ccgaagaact gccatttgcg gtttgtgtat cagtttccgt cagcgctaag 2756401 tattttccct tgtttatcat gccgctgttt tcatggatgg agaagtcgcg aagatgcgtc 2756461 tcatagatga cggcatccac agggtgtgag aatggtttaa gaggagcagt ccatttcatt 2756521 tgatccgggc gcaagacgac gcccttctct ccatttacag tcacagcctt ggcatactgg 2756581 tcaactgttt ccatccattc tgaattgttg cagatgcaaa acaaatactc atatccgtga 2756641 aggtcacctg tgaccgtaac ggcatagacg cctttttcca agcgagtcat ttggaatgtg 2756701 cgcccgcttt tattggggtg tgaaagcttg acagcagctg aggttgcagc aggcgcccat 2756761 actttaaata cggtatgatc cgcggtataa acggcgccca gctctccgtc ataataaaat 2756821 tcgtcatcaa acgctgccgt ccggatgacc gcgccaattt ggagatccgt tttgtggccg 2756881 ctggatgctc tgacgcaatg gatttttcca aatgtcacag gatggtcgga tacgcagacg 2756941 tacttgtatt ttgcttcaag ggagtattcc tccctgacag ccagaggaaa atctgttatt 2757001 tctgtctcaa gccgaaacgg cggtgtcatg atttcctttt gttcagcagg aatcagaaca 2757061 gtaatgatat tcatgtcatc gacatacgct tcgaagctgc ggcggatgct gaccatcgga 2757121 agctctctcc tccaaacacg tttatgtttt gattcttagg ggtgaaggac tagatgccag 2757181 acgaaacggg gtagtgccca tgatttctcc gtcagcatgg aacgggattt tgtccttcgt 2757241 gtaaaatgta atgtccttcg ctttaaacat cgtaacgcca tccatctttg tatgttttcc 2757301 aaatgccatg agacataaaa gccaatattt tttcaaaaac ggctggtttt caacgattac 2757361 gatatcaaat gtcttctcgc gcggatttgc taggggcgcc gccttcatgc ctcccccgta 2757421 aaacggatgg ttggatacaa cggcaaacca gacatcatga aattcgcgcg tctcgtcttc 2757481 cgtcgtacaa gctaatgtaa acggcttaaa ggttgccgaa gcgtgcaaat gagaaagcgg 2757541 atacacaaga aatcgaaggc ggagaaaaag aaaaacccgt ctcaacggaa attccatcgc 2757601 ctttttattg acatatgcgt caaacccgat cccgatatga ttcataaaat aaagaatctg 2757661 tgatttatcc tgaaggaaat tgacgctccc taaatgaaag gttcttgtta acgggcgctt 2757721 taccttcttg atttcctgta tcagatcgat ttttttaata gagaaccctc gcgaaaaatc 2757781 attatacgcg cccgccggca caaagctcag ctcaatatcg tcaacatctt tcagcccgtt 2757841 gacaacttca tgcatggttc cgtctccgcc aatgacgatc aggcgcttca gcttatattc 2757901 ctgtatcgtt gaaatctgtc tggcgagcac ctcggcgtgt cccggatgtt cagttaaaaa 2757961 tgaacggtgc tcaacctttc gtttgatcaa ttctttttga atggacttcc aaacacgcag 2758021 gccgtttcga tgtcctgctg tcggattaat aataaaaaac caatggctca tctttctcac 2758081 ctgcttatgt tatgagaaaa ccgctcaaat cgttctcttt tactccagcc actcctgtct 2758141 gcgataggag tcagacatgc agtaagacaa tagagccttt gcagccttta cctgatgatg 2758201 tttgatcgga gcagtgtttt tcttctgccg ctcaatccat tcttccgcgc tccgcttatc 2758261 cgctatttct aagccgtatg gcggctccgg gtaatcgatg tacgacgttc tgctcagaag 2758321 caattttcga accggaatct cagcctgttt ttcctttacg atctttgaca caaccgagtc 2758381 cgtacgaaac aggctaagcc ctggatttaa cactgatgca gtctgagagg ctgttttctt 2758441 gtcccaaaaa cgatttttag accctatgta gacactgtct tcctcagcct ctaaaaaaga 2758501 aacgcaataa atttccagag gagaaataat cacaatgctt aattcaaccg ccgcctgctg 2758561 aattttcagc acaggcttat acataataaa ataagaatca ggcagctgct gggtcagata 2758621 acgcaaaatg cggtcctgct tcacttggtt tgagagttga gatatttctg aaagagtaga 2758681 gcttgcccat ttgagctgaa aatcatataa atgcctttta taaaaagaag caagcgccac 2758741 cctgctcttc gggagcctta catgaatatc ttcttcgtcc tcaaaccatt ggtgtctctc 2758801 ttcttgtata tcggctttta tctcttcttt tcttcttttc aatgaaaatt tttttcgttt 2758861 ctgcaccggt tccggttctt cagcactggc ttgcctttct tcatgctggc gctccgctgc 2758921 ttctactagt gaaagccagc gctctttttt caaacgtaca aactggttga tataatggta 2758981 cggatcaagc tcatatctcg atatataatc atgaattttg atgatttgtg ccatgtttgt 2759041 ttctccactc cgcaatgaat taagataatt gaaatttgaa tatttcctcg tattttggtg 2759101 attggttcaa gtgtatttga aagagcgaaa atcgttcagc catcatcgaa acctcgccgc 2759161 tttcaaacgg aacatgagct ggaaatccat cttcgcctgt ccattttctt gccagcgtca 2759221 tatgaggatg atacggtctt ttttccactt gaaagccggc ctgaagtaca gcctgcttcg 2759281 tatgttcccg cagtctatca agcgttttgt ttttctttgg ctccagatgt aaaacgcgcg 2759341 gctttctgcg gtcgccgaat acatctatct tgccaaactt aattgaaaat ggatcaattt 2759401 ctgaagcaat ctctgctagc gaaccttcaa gcttctttat ttgtgtctca tccgccgctc 2759461 cgagaaaaat taacgtgata tgatagtcaa gcgggtgcac ccatttttga aacgtcaata 2759521 tcggttcgtt tttcgcagcc tggtagatcg gatttgcaat tccctcaggt atgggaacgc 2759581 cgatgaaata atgaggccgt atatctggca tccgtctgac actcccttct ttgacagcta 2759641 ttattttatc aataaagagg ctgtgcggat agaggaacag tgtatgaaaa cactctcgca 2759701 caaacgttta ttatgttagg atattatatg acacttgttt tattcagaaa ggaatgacaa 2759761 tgttgaaaat cgttgcaaac acagctgatc tgataggaga tacaccgcta gtgagattga 2759821 atcggcttca gccggaaaat gcggcacaag tctatttaaa gcttgaattt ttcaatccga 2759881 gcggcagtgt gaaagacaga gccgcttatc aaatgatcat agaagctgaa caaaacggtt 2759941 tactcaagcc gggatcagtt attatagagc cgacaagcgg aaataccggc atcgggctcg 2760001 ccatgaatgc ggcagcacgc ggatataaag caatcttagt tatgcctgat acgatgacga 2760061 aggaacggat caacctactt aaagcttacg gtgcagaggt tgtattaact cccggagagg 2760121 aaagaatgcc gggcagcatc aaaaaagcga aggagcttgc cgaacaaatt ccgaacagct 2760181 atattccaat gcagttcgat aacactgcta atcctgatgc gcaccgaaaa acaacagcgc 2760241 ctgaaatcgc ccgggcaata gaggaaatcg gaaaaccgct cggcgctttt gtagcctcct 2760301 ctggaacggg cggaaccatt accggaacag gtgaggcgct caaagagctt tttccggata 2760361 tcacggttca tgttgttgag ccagcgggtt cgcctgtatt atccggcgga aaacctggcg 2760421 cgcataaact tgtaggaacg agcccaggct ttataccgcc gattttaaat gaagacgttt 2760481 atgatgaaat tatcaaaatc tctgatgaag acgcgtatac gacgacaaga cggcttgctg 2760541 ctgaagaagg aattcttgtc ggtccttcat caggcgctgc ctgcttcgcg gcaatcgaaa 2760601 cagcgaaacg cctctctcct gacaaagttg tggtctgcat gacagctgat acaggagaac 2760661 ggtacttatc aactgattta tggtcattta tttaaaaaaa ggactggctt cagcagaagc 2760721 cggtcctttt attttgcaag ctcgtaaatg gcctgagcat ataacgctgt cgatctcagc 2760781 aggtcatcaa tttcgatata ttcatccttt tggtgtgcgc tgtcagggcg tccggggaac 2760841 agcgggccga acgcgacacc ggcttttaag gatctcgcat aagtcccccc gccgattgag 2760901 attaaatcag cttttttacc cagctggcct tcataaacct tttgcagggt tttgactaac 2760961 ggatgatctg cggacacgtg atgcggcttg ctgtctttga attctcccag ctcaaattca 2761021 gatgcgcttt cgaatgtatc gcggatcact ttgctttctg ctgtcacagg atagcggata 2761081 ttgatcccga gctcgcctcc ttgcccttct ttatagcgca gtgttccgac atttaatgtc 2761141 agctctccgc tgatttcatc ctcacagtcg atgtccagtt tttttcctct tgtatcacct 2761201 gagaacttat ctgtcacaac ttgcacaaac cgctttcctg catcgtcaag ctcagtctgc 2761261 tggagaaatt cgcacaataa aatgccggca ttgatcccat tgttcggttc catcgcatgg 2761321 caggaaagac cgtacatacg caaaatgagc tgtccgttct ctattgcagc ttcccctttt 2761381 tggtccgtcg tgcggagcat gtctttaaat gaagacagaa tctcttcatt tttcggccct 2761441 tcaatgacag cttccgcagc gtcgggcacc atgtttaagc gaaggcctga ttgaaacgag 2761501 acaagcactg cctttggttc agcttgattt gggcggtgcg gaataagtaa agaagcatcg 2761561 atgatccctt tttccgcatt aatgatcgga aaatcggcgt caggcgcaaa gcccattgtt 2761621 ggcatttctt catgcttgaa ataatgctct acgcatctcc aatcactttc ttcatctgtt 2761681 ccgataatca ttctgactcg cttggacagg ggcaaattca tgtctttcac gattttcagc 2761741 gcgtagaatg ccgccattgt cgggcctttg tcatcaatgg cgccccttgc ataaatccgt 2761801 ccgttgcgga tttcagctga aaatggatca ctcgtccacc catctcccgg cggcacgacg 2761861 tcaacatggc aaagtacgcc gataatgtca tcgccctccc cccattcaat atgacctgcg 2761921 aagccgtcaa gattttttgt tgtaaagcct tctttttctc caagctccag caatgaagtc 2761981 aggctggcat ttaccccttc tccaaacggt ttaccgggtc cggcggttgt ttcgtccatg 2762041 acactgttga ttctcaaaaa ttcctgtgta tcacgaatta aatcctcttt ttttctgatc 2762101 acttcaactt cccagttcat aatgatcccc tttccgcaag aaatgacttg caaaaaccaa 2762161 ataaaacgaa taatattaat ggtgttttgt taaaacgttc gtaattggag gatactatgt 2762221 ttcatctaaa agagcagcaa acatccataa agcaagaaat catagcaggg ctgacgacct 2762281 ttttcacaat ggtctatatc gtcgtggtca atccggtcat tctggctaac gccggggttc 2762341 ctttcgacca ggttttcacc gcaacgatta ttgcctccat tgtcggaacg ctgtggatgg 2762401 ccctggcagc aaattatccg attgctattg cgcccggcat gggcttgaac gcttatttag 2762461 cctttcatgt cgtaagcgca agcgatggcg gcatcacgta cgcaacagct ttcagcgcag 2762521 tatttacagc aggggttctc ttcattattc tatcgttaac gcctttaaga aaacaactta 2762581 tagaagcgat tccaaacaat ttaaaatacg ggatcacaac agggatcggg ctgtttattg 2762641 cttttatcgg tttgcgtcaa gcgggaattg tggcagctga tgagtcaaac ctggtcactc 2762701 tcggcaatct gcattcacct ggtgttatct taacgctggt cggccttttg atcagcgtgg 2762761 tcctgatggt gctgaatgta agcggcgctt tatttatcgg aatggcagct accgctttga 2762821 tcgccttttt caccggtcag ctccattttt caaagggatt tatgtcgctt cctcatttgc 2762881 cggaaggatt gatgatctca aatccattta ccgcttttgg cgatgtcatt catcacggcc 2762941 tgtacgctgt cgtcttttct tttctattag tcaccatttt tgatacgaca ggcacgatga 2763001 tcggagttgc cgagcaagcc gggctgatga aaaacaacaa gctgccgaac gtgcgaaaag 2763061 cgctgcttgc tgattcaacc gcgacgacag taggagctgt tttcggcaca agtccgacga 2763121 ctgcatttat cgagtcttcc gccggtgtcg cagccggggg aagaacgggg cttacggctt 2763181 tgactgtcgc ggtgatgttt gcggcttcaa tgtttttcag tccgcttgtc agcgccttgt 2763241 caggtatagc cgccatcacc tcgcctgctt tgattatcgt cggcagcctg atgatgggct 2763301 cagtttccaa tatgaactgg aaagagatgg acgaggcatt tcctgcgttt ctcgtcattc 2763361 tagccatgcc tttgacctcg agcatttcta caggaatcgc gcttggcttt atttcgtacc 2763421 caattgtaaa agcggcgcgg ggaaaatgga gagagattca tccgctcgtc atcgttttcg 2763481 ccattctgtt tttcatccag ctgtttattt tataaggata gaccaaaaaa cccaaacgtc 2763541 gccgtttggg ttttttatgt aaacaataaa gagacagcgg ccgctaaaaa acaacaggcg 2763601 gcaaacgcat agtgcaggat gttgatacag ctttttctgg cccgataata ttcatcactt 2763661 tccttatcgg tgccaattaa aaaaggggca tccatgacct tgtcaaaaat aagcgtcagg 2763721 atataacggc aaacccctgt gtataccagc agcgcaatca ccttcagcca aattggggaa 2763781 acaaatatga gaacagtgaa agctgacagt agcatgtaca tctgccttgc atactcgcca 2763841 ttcctcagca taactttaaa aaacaactcc ttatagcctg tgcagatcgt tcgtctttta 2763901 aatatccttt ttgaatttcg gtataataat ggttttcttc tcatcctgtc ttttactttt 2763961 ggcattcccg cctcctgact catcatcatc acaagtcctg caagggcaag cctgcttttt 2764021 ttctcttcag tcacctcagc ttcaaaagcc gtgaacgagg ctgtcttttt caaactgcgg 2764081 ataactgaga aaaacaaaaa taaaatgcca aaaagcgcaa gcaagtgccg ctcagtaaaa 2764141 acaatcagga tagcagaacc agcaaaaaga atagctctga caagggtatc gccaatccat 2764201 ctcgaaatgg agcgcggctt tctgatcctg tcttgcttta aggataaaaa gaatatatga 2764261 aggccaaaca aataacacaa tagagcagtg ctttctgcga atgtgatgag aacagaatga 2764321 ctgatcaagg gaaggacaat gaaaaagaga agcagccatt tagccagcgt ggccagaaaa 2764381 gaatacaaaa gcgcataccg tttgagctga tagatgattt ccttcttttg cagcaaaaac 2764441 actttgtccg cttccattaa aaatgtacga atcgaacctg taaacatgat cagcacacac 2764501 acagcataca gccatctcca ttccgccact tcagaccact cataaagaag gcctcttccg 2764561 ttcatcaaat caatatactg atagatgaca aaagcaatcg ccggcaaaac gatatagaga 2764621 gcgactgtcc agtcaatgac cgcatgcaac actttaaact gatacttata atagtcaaac 2764681 agccttcgaa aaaagagcgt acgcccgttc atagccgatc accttgaact gccttataaa 2764741 aacagtcaag caatgactgc ccctctaatc cggtcttgtc ctgaacatct tttaacgtgc 2764801 cttggagaaa taatgaacct ttctcaatca tataaaaccg gtcacagatt ttttccgcgg 2764861 tatcgagtac atgcgtgcac ataagaattc cggctccacg ttctttttca gccttaagca 2764921 tgtccacaaa gcgtttcgtc gatatcggat caaggccgat aaacggttca tcaatcacat 2764981 acatatccgg cttagagaga aaggcctgga taagcattag tttttgctgc atgcccttcg 2765041 aaaaggtgac aggcagctca tgtttgacat gatctagcga aaacgtctgc agcaggcttt 2765101 gggcccgatg cgcaaattca ctctcttcaa tgccgtgaag tgtgctgatc agatccaaat 2765161 gctcccacag cgtcagttct tcgtagaagg acggatgctc cggaatatat gcaaatgaac 2765221 agtcgttcca ggcaatatgc cctttaaaat cttctgaaag gccgagtatc gccttgattg 2765281 cggtgctttt tcctgcgccg ttagctccga tcagtccaac cagttcccct tttctgactt 2765341 ccagaaaaac atcggtgagc actttttttc ggcttgtata cccggcctgt tctattgaag 2765401 cttcaagcaa atttgtcaaa actcactcac ctccaaaatt tactacgaaa tagaataaaa 2765461 aaagtttctt taaccataat aatattgagc cgaaatacat agtaatccaa caaggatggc 2765521 tgcccaacgc gaaattggaa aaaattaata ggagttatcc ctagattcat cactgcaata 2765581 tcgtgtataa tgagggcgaa ttattttaac aattacagat gtctgccttt gttgctattt 2765641 cgtacgcagt tgatagtcgt gagttgtggt tagtcaagtc catccgatct tatgataggg 2765701 agtggttttt tgaaaccttc aacaaaccgt atgctaactc gaatcaaatc agtttacatg 2765761 tttattcaag aaaaaggtct tgtgacaaca caggaactgg ttgacgaatt cggcattaca 2765821 cctagaacga ttcaaagaga cttaaatgtg ttggcatata atgatcttgt tcatagtcca 2765881 agccgtggca agtgggagac aacgagaaag aaagtaaaga ttacctcata aattgaaaat 2765941 tacatagggc cgcctgagag cggtccgata gataacaggg cgaagaaact actgagcctt 2766001 gtttttgtgt gcttataaat aaaaccccgc attcggtatg cggggttttt gtcatgcttg 2766061 cggctcattt agcaaatgaa gctcttcctc tgtcagctca cggtattctc cgggtgccag 2766121 agcgggatct agggaaacgc gtcccatcga aagccgcttc agataaacca cttcattgcc 2766181 gactgccttt gccatttgct tgacctgatg gtattttcct tctgtaattg tcagatatat 2766241 aacggtattg ccactgtcgt ttgttttgat ttccgctttt gccggctttg ttttatagcc 2766301 gccctctatg tagacacccg tttccaaatc ggaaatgtct tcccgagaaa tctgtgattt 2766361 taaatggact tcatacgttt ttggaacatg ctttttagga gaaaggagcc gatgtgcgag 2766421 ctggccgtca tttgtgagca gcaaaaagcc ctctgtatct ttatcaagcc tgccggctgg 2766481 aaatggctca aatctcatct cctccggcgt cagcagatcg accactgttt gctgccggct 2766541 gtcctcagtc gccgacagca cgccctgcgg tttattcatc ataagataaa tgaactctcg 2766601 ataatcaacc ggttccccgt atacggtcac ctcctgcgta tcaggatcaa cgtgctcctt 2766661 tacatctttg gcaggtttgc cgtcgatcat cacggctcca gccttcacaa cggctttgac 2766721 ttcttttctg gaaccatacc cgctgttggc aagcagctta tcaagtctca ttcccaatct 2766781 ctcctttata aaagaaagcc cgcagcatgc gagccctcag tttcatcata tctagttcat 2766841 cagcctgcat gtctgccttt cctaaagaaa cctggcaaac ggcggcctaa aattttctgc 2766901 aaaaatccta atcggtagcc gcaatacagg tagacagctc cgccaacagc ggccgcgatc 2766961 accacaacaa tcgcagcttg catctggcca tcctgatagg aaataaagaa gcctaatacc 2767021 cactgcacga ttttcacggc aatacccata atggctgata agaccagcat caaaacagtt 2767081 cgtttaacaa gtatcttata cgaatagcct gcatggcgct taatcatgat aaacccatat 2767141 aaaagggaag cgatatatcc aagcgccgtc gctaaaatcg ctccgtcagc ctgcatcagc 2767201 ttgatcagcg gaacattcag cacaagcttg atcacgacac cgatcacaag gctgacaacc 2767261 gcaaattttt gcttattgat gccctgcaga atagctgcgt tgactgtaaa caaagagaac 2767321 agaattgcga caggcgaata ccaaagcaaa atgtttgccc ccagttcagg atgaaggctc 2767381 tctgacccgt aaaagaacgt atacgtcggt cctgacaata gagagatccc gacaacagcc 2767441 ggaataatta aaaacaggat cgtctgcatc gtttgattaa tctgctgatt taacagctta 2767501 tagtttccgc ttgtaaacga ttcagtaatc gttggaatta atgtcagtcc aaaagcagtt 2767561 gctagggaaa ccgggatcat cacgagcttc tgaacataca gggttagaat cgcaagcatg 2767621 tcctggctga tggcttgatg accggcttca atcatcgctt tgttaaacgt atttgtatca 2767681 atatagttat acaaagggat ggctagtccg acaaaaacgt acggagcagc atagctgaac 2767741 agctcgaaaa acattttctt gtagcttagg tttgctgtcg gacccgtatt cggcatcatc 2767801 gccagcaggc tgcccttccg tttgttccaa taaatataaa gcacgaccag ccctccgaag 2767861 gcaccgatca gcgctgcgaa ggttgcatag cccacagcga tgacaaggcc gccgttgaaa 2767921 accttcaaaa tcaagaatgt cgcactcaat agaaagatga tgcggacaat ctgttcaacg 2767981 acttgggaaa cagctgtcgg acccatcatt tggtgccctt gaaagaatcc gcggacaagg 2768041 ctcataatcg gtacgaccaa aagcgctaag ctgaccatgc ggatgacata aacgacatga 2768101 tcaattgtca ggccgttatt atccttgcct cccagcgata tttccgcaaa catcggagcc 2768161 gatagataca gaatgaaaaa ggctatcatt cctgtgacta gcataaccga catgcccgcc 2768221 ttgagcattt tcctgcttgt ctcataatcc ccttttgaat tatatttgga aacaaattta 2768281 gaaacagcgg ccggaaagcc catcgtagca atattcaaaa ataaagtgta ttggttgtat 2768341 ccgtattgaa ataatgcacc gcctgtcgcc ccgaccataa tgctgaaggg aattaaatag 2768401 accatcccca gaatccgcga tatatatgta ccgagcgtta atacaaacgt gcctcttaac 2768461 agtttgcttg acatgtttct tcatcaccat tttctacgaa gattcaactt ttctatttta 2768521 ccacaactgg gcatttagac ggtaataaat acaaaagcaa tcctgtgaac attcatgtcc 2768581 gcggcaaaag acgtttaagg agcggctttc tttcgctata atagtactgc ggacgggtgt 2768641 ccgcacacga aatgaaaaga aagttgatga taaagatgaa acaatatgac gtaatcgtaa 2768701 tcggcggagg cccttcaggc ttgatggctg cgattgcagc aggagaacag ggcgctggcg 2768761 tgttgctgat agataaagga aataaattag gacggaaact cgcgatttcc gggggcggcc 2768821 gctgcaatgt gacgaaccgc cttcctgtgg aagaaattat caagcacatc cccggcaacg 2768881 ggcgtttttt atacagcgcg ttttctgaat ttaataatga ggacattatc aagttttttg 2768941 aaaacctcgg cattcaattg aaggaagagg atcacggccg gatgtttcct gtgaccgaca 2769001 aagcccaaag tgtcgttgac gcgctgttaa acaggctaaa gcagctccgc gtaacaatca 2769061 gaacgaacga gaaaattaaa tctgttttat atgaagatgg acaggcagca gggattgtga 2769121 cgaataatgg cgaaatgatc catagccagg cagtcattat tgctgtcggc ggtaaaagcg 2769181 tgcctcatac cggaagcacg ggagacggct atgaatgggc tgaagccgcg ggccatacca 2769241 taacagagct gtttccgaca gaggttcccg tcacttctgg cgaaccgttc attaagcaaa 2769301 aaacacttca gggcttatca ctaagagatg tagccgtcag tgtgttaaat aaaaaaggca 2769361 aaccgattat cacacataaa atggacatgc tgtttaccca tttcggcctc tcaggacctg 2769421 ccattctcag atgcagccaa tttgtcgtaa aagagctgaa aaaacagcct caagtgccga 2769481 tcagaatcga cttgtatccg gatatcaatg aagaaacgct tttccaaaag atgtataaag 2769541 aactgaagga agcaccgaaa aaaaccatta aaaacgtgct gaagccttgg atgcaggagc 2769601 gctatctcct attcctgctc gaaaaaaacg gcatctctcc gaacgtatcg ttttctgagc 2769661 tgccgaagga tcctttcaga caatttgtaa gggactgcaa gcagtttact gtcctcgcaa 2769721 atggcacact gtcgcttgat aaggcatttg tcacgggagg cggggtatct gtaaaagaaa 2769781 ttgacccgaa aaagatggct tctaaaaaaa tggaggggct ttatttttgc ggtgaaattc 2769841 tggatatcca cggctacaca ggcggataca atattacctc cgcccttgtc acaggcaggc 2769901 ttgcagggct aaatgccggg caatacgccc gttcttaatc attactcttt aaatctcttg 2769961 ccgccaaact cacatttgaa cattccccgc attcatgtta gggtgagact tgttttgttt 2770021 cacctgattg cggggtaatt ttaagagagg aatgagctgc catcgtacga ccatactaag 2770081 cctgcgagca agatataggc gtacacaaaa aattagaggg tgagaaatgt tgaaacatat 2770141 atctagtgta ttttggattg tgattgcaat cacagctgca gctgtattat ggggtgttat 2770201 ttctcctgac agcctgcaaa atgtgtctca atcggcacaa gcatttatta ccgattcatt 2770261 tggttggtat tatcttttag ttgtctcttt gtttgtcggg ttttgtctct ttttgatttt 2770321 cagcccgatc ggaaaaatca aactcggaaa gcctgatgaa aaaccggaat tcgggttatt 2770381 atcatggttt gccatgctgt tcagcgcagg catgggaatc ggcttagtat tctacggtgc 2770441 ggctgaaccg atcagccatt acgcaattag ctctccatca ggtgaaacag aaacccccca 2770501 agccttcaga gatgcactcc gctatacgtt tttccactgg ggtttgcacg cttgggccat 2770561 ttatgccatt gtggcattat gcattgccta tttccaattc cgcaaaggcg cacccgggtt 2770621 aatcagcagc acactgtcac cgattctcgg ggataaagta aacggaccga tcggaaaggc 2770681 cattgactgt attgcagttt tcgccactgt tgtcggggtg tcaacaagtc ttggtcttgg 2770741 cgcaacccaa attaacggcg gtttgaatta cctgttcggc attccgaatg cgtttatcgt 2770801 ccaattggtt ttaatcatta ttgtgacagt gctcttttta ctttctgcgt ggagcggact 2770861 cggaaaagga attaagtatt taagcaacac aaacatggta ttggccggat tgttaatgtt 2770921 gtttatgctc gttgtcgggc ctacagtgct gataatgaac tcatttacag attctatcgg 2770981 acaatacatt caaaatatcg ttcaaatgag cttcagactg acaccgaacg atcctgaaaa 2771041 acgcgaatgg attaacagct ggacgatttt ctattgggca tggtggattt cctggtctcc 2771101 atttgtcggc attttcatcg cccgtgtatc cagaggccgg acgatccgcg aatttttaat 2771161 cggcgtcttg gtgacacctt gtattttgac atttctatgg ttctccattt tcggcgtatc 2771221 agccatggat ctccagcaaa aaggcgcgtt caatgtagca aagctgtcca ctgaaacgat 2771281 gctgttcgga acacttgatc actatccgct gacaatggtg acatcgatcc ttgcattgat 2771341 tctgatcgca gtattcttta tcacgtcagc tgattcagct acattcgtgc tgggcatgca 2771401 gacgtcgtac ggttctttaa atccggcgaa ttctgtgaaa ctcagctggg gtatcattca 2771461 gtccgccatg gcggctgtgc tcctatattc cggagggctt gccgctttgc agaacacagc 2771521 gattctggca gcgctgccgt tttctatcgt tatcctgctg atgattgcct ctctctatca 2771581 atcgctctca aaagaaagaa gagagatcaa aaaagcggag aaactcgata aaccaagaag 2771641 tccaagagtg aaaaaagcat attaacaaaa aagatctttc cgcgcctgcg gaaagatctt 2771701 tttatttgcg atataaaata agggcggaaa aacagtaaag ctgctcgccg tctgggtcgc 2771761 acgccgccga aaccgtatat ttgatatcta tcagctgctc ctccgatatc ccttttaaaa 2771821 atgaattgat ttccgtttgt aagtcttttt catgctcttc atcaaatacc gctaccttca 2771881 gcattttatc cgctctcctt tctctatcaa tctattccgt ttggaacagc gttatgatag 2771941 agaaatgatg attatctcgt ttccggataa aaagctttcc gtatatggga tttcctctgt 2772001 ggctcgccgc cgtgctgctc cactttcagc agcacggcat aaacaatgcg catatggcag 2772061 tagctgataa ggctgacgct gaaaaaaggg acaatgcccg gcaggtacgc aagcaagaaa 2772121 aagagagcaa cagtcagcgc aagcatagta agcgtatatt gcaaatacgc cacactgagc 2772181 aagagcgaaa atttcacata cagacgtttt ttccagtcaa aatggacaag cagcggaaac 2772241 acataaaaaa gcatggatac gaacaaaaag ccaaatatca taatggcgaa gcgcaggatg 2772301 tgcagaagga aatgacttgg ataaattaag gccaaatcaa tataaatgat cactccgatg 2772361 agcgccagta cagcgccgag cagatttgaa cgaaaaaatt cacccttgta ttcctgccaa 2772421 aacgttttga gcaccggaac gttgtcctgc ccctggatcc acttccgcat gacagcgaat 2772481 aaagccgcgg tcgcgggcat gatgccaaac acgccgagac cgagcaacgt aaaaaacagc 2772541 cacagcaagt ttgtatacgc aaatctcata atccattcgc aaaaacgcag catccgtccc 2772601 agtgagccat catgttccat ggcgccccct ccttttttgc attatacatt ctgcatctga 2772661 aaaagctctt tcatgccgat cggcttcttt tcggcaaccg agcgccacat tccctcacca 2772721 accgcgatgg agtaggctcc agcttcagcc ccggctaaaa tatcatagcg gcgcagcggg 2772781 tctttcccta aaaaaagatc ctcaagcaaa agcggatcac ctccgccatg ccccccttca 2772841 tttttgacca cttgtatcgt ctgctttgat tcaaaaagcg gatagtattc gattgtctgc 2772901 tcaggaaaag caaacggaat tctggaaggt tcgtgaaatt catttgattc aatacgtcct 2772961 tttgtgccgt tgatcgtcag ccggtagcct tcatacgggg ccgaaaaaat aatcgagtag 2773021 cttaacagtg cgccgccatc atatttgact gccgccacgt acgtatcctc gatgtcaatt 2773081 tcctcgtcaa aaatacacgc gtcaggcctg tatgcagtat ataagctgga ctggtctcct 2773141 gcttcaagat gatcatcctt tatagaagct ttagaggaac ggggatgcca ccttgaatag 2773201 tagtggcatt tttctttaac acggcacgtc ccgcaaaaac gcccgtcttc ttccggcaag 2773261 gggttccact cactgtccgg cccatagtaa ttcaaggcgc cataagcaaa tacctcttcc 2773321 ggattttgcc cgagccacca attgacgaga tcgaagtgat gtgttgattt atggacagaa 2773381 agaccgccgg aaaactgtct cgacctgttc cagcgtttaa aatagctggc gccatgatac 2773441 gtatcaatat accaatttaa atcaacagaa gtgaccctgc ctatttttcc gtccagaatc 2773501 atttctttta ttttccgatg aaacgggctg tagcgatagt taaacgcgac ggtgactttt 2773561 ccttcgcttt tggcctccgc ttcaagcacc cgattcgcat cctgcactgt tgtcaccatt 2773621 ggtttttcag taatcacatc tgtattccac tgaaggcttt ttacaatata tgcgacatgc 2773681 gtatcgtccc tgcctgccac aatgacgata tcaggctttg agacgcgcat catctcgtca 2773741 aaagcatctt cgctaaactc aggcacgtgg gccagctcgg gaaatttctt cttgcaaacg 2773801 gcaaaacgtt tcggatcggc atccagcaat cccgtaatct cataatgagt tgaaaaccgc 2773861 tccatcagtg gtttgataaa catactgaat gctctgctgc tcaatccgca aaagacgatg 2773921 ttcttcaata tcctcacctc tatcgggctt cagttagttg agaaatcagc tgcagcgctt 2773981 cctctgtttt ttcagcatac acagggataa acgccgccat atcgcgattc aattgaaaag 2774041 aatagccgtt cagctgtttt ttcccttttt cgatctgaac ggcatagatc gttttttctc 2774101 ctgttttttt attaacagtt gtataaggag atgttttttc aggaggcaat ccgtttaacg 2774161 gctgaaaatt ttccggatca tcgtaagctt gaaacatgtc ttcaggcacg atgaaaacat 2774221 ctccctcatg ggcggtaatt tcagtcagca gtttttcctg aaaagctgga aagatatcga 2774281 ccttcccggc attctgctcg gcggcctttt ttattttttc ctgtacgcca gcctgcatat 2774341 cagaaaagag aatgacatgc attccgtccg gcctgcttga gcatgatgcc aaaaagagca 2774401 ctgagacgat cacacacaaa gccgtacgta tcctttttgt catttccccg ctgacctaaa 2774461 aagaggctcc agctctgtca tagctaaaat aaacgcgccg gctccgtgca gatcgtttgt 2774521 gcttctttcg cggctgacat aatagtcata gaaaccggct gacgttccga cacatatgtc 2774581 tttgacgaga aacgctccgt cttctgatgt ttcggtttta tgctgaatca agccttgata 2774641 cgcttttagc agtgttgttt cgtaagctct gtctagatag cctttattga ttccttttgc 2774701 gattgcgtac atgtacagac aggatcctga gctttccagc cagttatcag acctgtctcc 2774761 cttatcaacg atctggtacc ataaccccgt ctctttgtct tgatagcgac agatgctttt 2774821 aatcatgtcc tgcagcgtgt ttttccacac atgacggttc ggatgcttct tcggcagctc 2774881 ttcaatcatg tcagcaagag acatgacgta ccagccgatg gaacgtgccc aaaattccgg 2774941 tgaacagcct gtctcttcat tggcccaagg catttttttc gcttcatccc aggcgtgata 2775001 aaaaagtccg gtttttgcat ccttcgtatg ctttctcatc aatgactcct gaagcacaac 2775061 ctgatcaaac agctccgtct cctgcttcag attggcatat ttcagtgcaa acggcccccc 2775121 catgtataag ccgtcaagcc acatttggta aggataaccg tctttgtgcc aaaaaccgcc 2775181 ctcagacgtc cggttcagtg ttccatataa gctgcgcagc ctttttgccg ctttgacata 2775241 ccgttcatcc ttcgtctgct cgtataatgg aaaaagaatg agacctgctt gaatggcgtc 2775301 cagttcatct cttctaaata atagattgcc attatcatcg attaagagat ctgcataagc 2775361 cttcgcatac tcaaaatacc gcttttcccc ggttgcttcc cacagccgca atacaccgca 2775421 taagaaaaca ccctgatggt agtgccagcg gtttgcaggt ggcagctcct cgactgtgta 2775481 cgtgttcata atggtgtttg ccaatgcctc cgcgtacgta agaggcgatt ttacagcgat 2775541 tgattgatcc attgatccca tccctttcct aataaattcc ttcctcgcca aatttcttcg 2775601 ccaaacgatt cgctagcatg accaaaatca gcccgaccgc cgctttaaat acgccgactg 2775661 ctgtactgta gctgaattgg ccctgtttca gccctgcagt ataaacatac gtatcaaaaa 2775721 tttccgccac ttccctgtta gtcgcattta acagcaaata cacatgctcg aagccaagct 2775781 ccagcgtgtc tccgattttc aaaatcagca aaacgacgat aacgctttta atggcgggca 2775841 gcgtaatatg ccacatttgc cgcagccgtc ccgctccgtc cattttcgcc gcttcataca 2775901 gctgggggtc aaccgctgta atggccgcca gataaatgat cgtcgaccag cccgcttccc 2775961 tccagataac ctgcagaata tacaggggcc ggaaccattc ttcgttcagc agaaaattga 2776021 ttttttcacc gccaaaaaac acaatcagtt cattaatcaa gcctccgtct accgttaaaa 2776081 gcacaaacga aagcgataca acaatgaccc aagacataaa atgcgggata taaatcagcg 2776141 tctgaacaaa ttttttaaag agagcaatcc gcacttcgtt caatagaagc gccagcagta 2776201 tcggcaccgg gaaaaatatg gccaggttca aagcaaataa cacgagcgtg ttttttaaca 2776261 agagaaaaaa tgtaggctca gtaaacagcc tgataaaatg cttcagcccc acccactcac 2776321 tgcccaaaat gccgaggaac ggctgataat cctgaaacgc aatcacaatt ccccacatcg 2776381 ggacatactt aaaaagcaaa aaataaatac accccggcaa aatcatcaag tacaaatatt 2776441 tttgttgaat cagcttgatt agtaagcgct ttcttttttc ttttttaaaa atgactgcat 2776501 caacagccgg cgcttgcgct tctgctgttt tcattttttc ctagcctcct ttcacggatt 2776561 cttgcattca ctgtagcgca gcaggcaaaa gtccgtctac aatcatatga tcacatcctg 2776621 ttttatccct ttataatcaa gggttcagcc ggtccacctg aaaaaaagac accgatatta 2776681 gaaaatgatt attgacaata tctatcaatc tttggattaa ttgtattaag gtgaagtgga 2776741 tgttatgaaa tggggggttt tatgaaaaga agccaataca agttttacta caaactgatc 2776801 acgtttttct gcctgctcag caccattccg gttattttgg tcggattatt ttcgtacgag 2776861 cactctcaga aaacggctat ttccaacgtt tcggaggaaa aattcgacac actccagcag 2776921 acccagcaaa gcatcgagca tatattgaaa accgtcgatc actctttaac ccactatgtg 2776981 agttcgccgc ctctccttcg cacattgtcc gagcctttgc actcagacca atttcaaatc 2777041 tataaccaag tgaaccaaga gctcaattat ctgcaaagct ttgataccga tctgtccaac 2777101 atgacgttag tcagttatac gaaaaaatgg tacatgaaca attccggttt gtaccgtttg 2777161 aatacagaca ctcttcatga agcagcctca gcgtacacga aacaaaaagc gagccgctcc 2777221 tattggacgc ttgaggaaaa caatcatttg atttcaacca aagaaggcac agcagaaaac 2777281 tgccgctaca atatcaattt aattaagcag cttcctttga acagcacaaa tacaaaggga 2777341 ttggccgccg caagcatccc gagctgttcg cttgtcaaaa atatgcccgg ctattcaaac 2777401 gccaacaacc tgtttatcat cgatgaaaaa ggcctcatca tccttcataa caatatgtct 2777461 gacgttggtg aatctcttca taacgacggc tttgtccaaa aagtgctggc gcaaacggcc 2777521 aatagcggac agtttgaaac agtgattgac cggattcatt ataaagtcac ctatcaaaaa 2777581 tctgactata atgcatggac ttatttttct ctcgtttccc tgcctgagtt aaaaaaagaa 2777641 gccaaatcaa tcggctggat cacttttgca gtatgcctca ttttgttaac gctttcattg 2777701 ctgttctctt ggcttggctc ccgccatttt tacaagccga tcagggtgct ttacgaatca 2777761 ttcgcaagac atggagccat acaagagaaa caacagcctc ctcaaaatga atttgagtta 2777821 attgaacaga gctttaagca gctgaaggac agaaatgacg accttgaaga aacgatgaag 2777881 cagcaggcca ctcatctgca gcaatatttt atggtcaggc ttatgcttgg aaaactgacg 2777941 gatgaggagg ttgataaccg ttttgaaagc ctcggcttaa agcaaaattg gcggcacctt 2778001 gccctgcttg tgctccaaat tgacacactg aatcatacgc cttatgagaa aaaagatatg 2778061 gatctgcttt tgtttgccgt caacagcctg attgagcgca acatcccgac ggacaaacat 2778121 cttgcccccg ccgtagttga caaacagcag gcgacgattt tgatcaatca aagcgggaca 2778181 aaggaagaat tcatggctga gctgaatgag actgcaagga tgattcagga aaaagcggaa 2778241 gctgagctgc agctgtctgt cagcatcggc atcagccagc cgtttgatgt gctgacaaaa 2778301 gcgaaaacag cctatgcgga aggctcagaa gcgttgaaat atcggctgaa agcggaaaac 2778361 aagtcgatca tcttttacga agaccttgac cagaaaaaaa ccttcaaaac ccattttcca 2778421 aagcagcttc agcatgagct gttcgatgct gtcaaagcag gagacaagga gaaagcggat 2778481 aaatgcctgc acgcgatttt acaagccatt ttcacccaga acaccaaccc gtatcaattt 2778541 caaatcgcca tcgcccgttt tttgaaccat gtgattgagc tgatgcatgt gcttgggatc 2778601 gaattgtttg agcttgaaga aaacaaaatg ctgtatgacc aaatttttga gctgaaaacg 2778661 ttcgaggata ccgaaaactg gctaaagaat gagtttattg atccgatgac agacaaagtg 2778721 aacgcccgcg cggatgccca gtacaaaaat atttccgaca acatcattca tatcatccat 2778781 catgagtttg aatccgaatt gacactggac gaaatcgcac gcaggctgca ttacaaccca 2778841 aattatttaa gcagtatttt caaaaaagaa atgggaattt cattcagcga gtatgtctca 2778901 agctaccgac accatatggc gaaaagctgg cttgccgaaa ccgacatggc ggtcaaggac 2778961 attgccgaaa agctgaaata taaaaactcc caaaacttca tcagatcatt taagaagctg 2779021 gaagggatta caccgggaaa ctaccgccag caaaaaagaa gcatgtaaaa aacccaaaac 2779081 cgcttgcgcg ttttgggttt ttccaatgtt attttgcttg tttaaacgct tcttcgtatt 2779141 cctgaataat ttgttttcct ccgcttgact cccatttttc cacttcttta tcgaactggc 2779201 tttctgtgat gtctccaatc atatatttgt aggtcgcgtc atcaatgatt ttcttcagtt 2779261 cgtcaccccg ttccgactcc gatgcggaat acaggctttc agccgggttt gagacgataa 2779321 tcttttcatt gtcctcggtc agctcctcgt acgccgtccg aagcggatct ccagtgtttt 2779381 ttaagtaggc tttatcaatg gcaattaaag cggacagcgg ctgaatatca gtctgccagt 2779441 cttttacctg gctttctttg cgtgtaaacg ttttgtcctc acctttgttg taatgaacgc 2779501 cgtcaatgcc ataagtcatc aggctataga catcttcttc ggcaattcgg tcaaaaaacg 2779561 ccaagatccg tttaagctca gcttccgttt tcacactcgt tttcgggaaa gcaaacacgc 2779621 cgttatggcc tcctgatgcc catacccgct ctttcccatc tgggcctttt atgcggttga 2779681 tgatctcgag cttcatcgat ttatcagagg catggtcgcg cagattgacc gcatctacca 2779741 tattgccaat ataaattccg gcttttcctt gagaaaacag ctcttgctgc tgggttttgc 2779801 ttgtgacggg aaaatcctta ttcatatacc cgttatcacg cagctttttc atatagttca 2779861 tcgtgtcttt gtattcctgt gtcatgaaat caggcgtgaa tttgccgccc gattccttcc 2779921 aatctgtcgg catgccttca tacgagccaa tcgttttaaa cgcgccgtaa atcaagtcat 2779981 tacggtctgc cagcccgaat gtatcatctt tcccatcctt gtccgggtcg tcctccgtaa 2780041 atgctttggc cacttcataa agctcatcca acgttttcgg ggttttcaaa tttaaattgt 2780101 ccagccagtc cttccgaatg acgatcccct gtctggaaag cgggcgctct ctgtatatcc 2780161 cgtagagctt gccgtcaatt gtcacatttt tattaatgag tttgttcatt ttgtttaagt 2780221 tgggataatc cttgatataa tcgccgattt cccaaaacat tcctgaccga aaggcattca 2780281 tgactgacga atttttaata tcctggatgg tcacgatttg cggaagattg ccggctgcaa 2780341 gcgctgcatt cagcctgtct tctttcaccg cgtctggaac ccaggtgatg tcgagttctg 2780401 tatttgtcag cttttcaatt tctttaatcg ccctgtcttt cggcggctgc tggtgataca 2780461 aaatcgccat ccaagacagc tttacctttg aatctgggcc agctttgcct tcagccgaag 2780521 actgatcagt tcctttacag cccgccagca ctccgccgag tgccagtaca agcacaatca 2780581 aaagcaccct ccatttgttt cccatcgtac ccctccgttt catatttctt tatcctttga 2780641 cagatcccag caaagctcct tttgcaaaat gcttttgtat aaacggatag acaagcagaa 2780701 cagggatggt cgccaccact atgaccgcca ttttaatggt ttgctcaggc ggcgggctgc 2780761 ccgaccccat ttcagacata tccccctgca taccgcttga tacaatgacg atttggcgca 2780821 gaagcacctg aattggccat tttgctgaat catttaagta caagatcgct gtcatatacg 2780881 tgttccaata cgtgaccgca taaaatagtg aaatcgttgc gatcgcagga agagacagcg 2780941 gcagcacaat tttaaagaat atgcccagat cattgcaccc gtcaattttc gcggactctt 2781001 ccaggcttga cgggatattt tgaaagaagt ttttcagaat gatcaggtta aaggcattaa 2781061 tggctgtcgg caaaataagc gcccagtaag aatcgagcaa tccaagcgat ttgaccacaa 2781121 ggaaagtcgg aatcatgccg ccgctaaaca gcatcgtaaa tacgacgaga aacatgagcg 2781181 gctgccggcc gattaaatca cggcgggata acccgtaagc catcagtgac gaaagaaaca 2781241 tgctgaccgc agtgcctatc actgtcacaa acacagaaac aagcaaactc ttataaataa 2781301 tatctgttga aaaaatgtag cgataagcat ctagcgaaaa agtggtcggt attaaaataa 2781361 attttttcga cacgacttct tctactgtgg caaaggatgc tgcgataaca tgaatgaacg 2781421 gaagtacgca tattaaagcg aacatcagca agaaaccata aatcaacata tcaaacagac 2781481 ggtttttcag tgaatgtgcg atagctccca cctccctttg taagcgttat catatttttg 2781541 gaaaccgagc tcagcatgtg acgatatcgt gtctaaaatg tagcaaatct gtgattgcca 2781601 tgtctataat catttgaaca gtgtccccgg ccgggcgggg gctgccgcga attgagaccg 2781661 ataacaaaag aaaaagagca taatcttaga aaatgattat gctccgttct cctcctcgtt 2781721 cagaagttca gccgtattga tttgtggcga aaacccaagt tcattcacgg cagattcaat 2781781 ggaccatggc cggcccggat tatcagagac ggcgtaataa gtgccatacc ggatgttggt 2781841 ctcaatggcg gctttgaaaa tcgacagcag atcggggtga gaaagcagtg tctttttcgt 2781901 ccgttctttt tcatgcagcg tatccatttc atctgtcacg actgttccga ttcgaaggtt 2781961 gattactgat agcttatttt ccaaataaaa caaatggccg atctgttcag aggtcagctt 2782021 taatacaccg tacaagtttt ttgacagcgg ataatcgctt gttgtgattt cccgtcctaa 2782081 gagcgagcgc ccgtcttttt catatacatc tgtgacatga ttgctgctgg cgaacacgag 2782141 cttttgaatg ccgagctccg ctgccgcacg gcacagataa tagcttgccc tatagaaaac 2782201 atccgtcatt ttttcaaact cagcgatgtc cataatatcg tatttgattt tcacagcgag 2782261 taaattcaag atggcatcgg tatcttttgg aatcttcttc aacagctcct cataatttgc 2782321 cgcgtcagcc tgaatggaag aggctttgcc atcgaaatga tctttatcaa gcacagtcac 2782381 ttcatagtct gaaataagcc cttcagcaag cagtctccca atcacaccat ttccgccggc 2782441 gatcagcact tttttcacga tgttcactcc ccttttttat agattgccca ttttcggcgg 2782501 ggctgacact tttttggcac tcacattctt aggcttattc aaaagtcacc ggcagctcct 2782561 caagcgcccg aaatccaaaa agcggccgat accgccattc aaaatccgca agattaaggc 2782621 tgggcattcg ctgcagaaga gtgttaatcg caatttgcgc ttctaatcgt gccagcgagg 2782681 accctaagca aacatgatgg ccatgcccga atgaaagatg cggattagga cttctcgtaa 2782741 tatcgaagac atcggggttc gtgaatatgc tagggtctcg attagccgct cctaacaaaa 2782801 gatagacttg ttctccttga cggatcgtca ccccgcagat gtcaatatcc tctgacgcaa 2782861 ctctggctgt catttgcgtg gggctttcat agcgtaaaca ttcctcgact gcggtaccaa 2782921 taagatctgg attttctctc agtttcaaaa gctgttctgg atgctgcagc agacaaagga 2782981 ctgaattgct gatgagattg accgttgtct catgtccggc gatcgccagc aatatgcacg 2783041 tagatgccgc ctcctcttcc gtcagcttat ccttttctct ccccttcaag agcatgctga 2783101 tcatatcctg ttgagggtgg cgttttctct tttgaatcag ctctttgaaa tatgccatag 2783161 cctgcacagc cataatattg ccctctgtta atgcctttct tgagcgggta aaatcaatcg 2783221 tttgaatgag actcgcagcc cactccttta attgctccct atcttcctcc ggtacaccta 2783281 taatgttagc tatgacaaaa cttgctaaag gaaaagcaaa gtccgaaatg acctccatct 2783341 tttttttacc ttgcacttga tcaagcaaat gatggacagt ttcaatgata tacggctgat 2783401 aactctctgt cgttctcggc gtaaacgctc cgctggcaag cgtccgcaat cgtctatgat 2783461 caggctggtt ctgaaacagc atcatttgat tttgcacatg tgaaaggtcc tgatatttgg 2783521 ttgagctctc aggcagcggg gtgcggactt tgaatctcgc atctttcaaa atagcagccg 2783581 tttcttcata tcctgtgaca taccagcccg ggtattttaa gaaactccct ttatagatag 2783641 gatgaacagc tcgcaatgtg tcgtaaaaag aatatgggtt tttcaaaaac tcagaagatg 2783701 cagttgacga tgcaattgtc acgtgatttt ctcctttctg ttcaaaaata aaaacaatcg 2783761 acatcatacc gattgctttt attgattctt tcagcttttc gcacttaaac tagccttcat 2783821 ttcttcgact gattcaactt caaagcctaa atcactcagc attttatgat cctccgtctc 2783881 ctcttgcccg gcagttgtta agtagtctcc gacaaaaatg gagtttgcgg cgtaaagccc 2783941 taatggctgc aatgtgcgga gattgacctc tcttcctccg gaaatgcgaa tttcttttga 2784001 tggattgata aaacggaaca gcgccagcac ttttaaacaa tacagcgggt ttaattcgtt 2784061 gacgccttct aacggcgtgc catcaattgc atgcaaaaaa ttcacaggaa tggaatccgc 2784121 gtcaagagcc ttcaagcttt tggcgatgtc aatgacatcc tgtttcgtct ccttcatccc 2784181 gataatggcg cctgaacacg gagacagccc cgattctttt gcgatttcaa ccgtattgac 2784241 tctgtcatcg tatgtatgtg aggttgtgat gtttgaatgg tttctctgtg acgtattcaa 2784301 attatgatta tagcggtcta ctcctgcatc tttgagccgc ttcgcctgct ctggcttcaa 2784361 cagtccaaga catgcacaaa tcttcagtcc atacgtctct ttaatttcct gaaccgcatc 2784421 tacgacctga tccacttctc tgttagacgg acctctgccg cttgccacga tacaatatgt 2784481 gccgatattc agatcgtgcg cccgcttcgc gccttcaagc agcgtttcct tattcaccat 2784541 ccggtaagac tcaatcggcg ctttcgaaat cgcagactgt gaacaatagc cgcagttttc 2784601 cgggcagagc ccggatttcg cattcataat catattgagc tttacttttt ttccgtaaaa 2784661 gtgttttctg atgtgaaaag ccccgtgcat taatagcaaa atatcttcat caggacaatg 2784721 taatattgaa agcgcctctt cgtcagtcac ttctgctcca gccagcaccc ggtctgcgag 2784781 ttccatccat tgattcattc tcataccccc acttgattca tcagtaatga tagattgata 2784841 tggtctttta ccatatgtag aaccgtttct ttcgtcacgt tggcaagctt tggcgtaacc 2784901 cctaaaatcg gcacaccgca taagcgctca atcatctcag gattggtttt ttcatcttca 2784961 tcaggagagt cactgattcc attgatgata attccggcga ttggaagccc catgctttct 2785021 gcatatttga cagttaaaaa ggtatgatta atggttccaa ggcgaggacg cgccacaata 2785081 atcatgggaa gctgcaacgc ttttatgaca tgactgacca aatagtcctc tcccaatggc 2785141 acagaaatac cgcctgcacc ttctacgatg aagcattcat gtttttctct aatccgcccc 2785201 caatggctta aaacctcttc catggtgaca gtctttccct caagtttccc tgcaacgtat 2785261 ggtgcaagcg gcgccttgaa ggcaaaaggc gtaatgtctt catgagaaag actggtctgc 2785321 gacatatctt tcagcaaact tgtatcacta tctggatgat ggcgcgatat cccgcttaaa 2785381 aatggtttat acaccccgac atgtctatta ttgtctttca ataaggcagc aagaccgctg 2785441 gatataaccg ttttccctac ttctgtatca gttcccgtca caaaaaaacc cctcaaatga 2785501 tgtgcagctc ctttccgatt gaatgaaatg tttgcagcaa atgatcaata tcacccatac 2785561 tgtggtcaga cgtgattgta attcgaatcc ggctttcacc cggcgcaacg gttggcggcc 2785621 gaatggcagg agcataaatt cccttgccct gcagtttttc agcaaatagg accgttttat 2785681 gggcatcgcc aatgactaca ggaataatcg gtgtgtgatc tcctttcacc acataaccca 2785741 tattcttcag actggttctg atcatgctga tataagaaaa taaaagctgt cgtttttccc 2785801 tgctggcttc aatgatgttg aaagcctcgt gagcagccgc acagctggct ggcggaatag 2785861 cggtttgaaa gataaatgtt ctggcatggt tcagcaaaaa gtcgatgaag accgctgatc 2785921 ctgccgcaaa acctccttcc gcgccaacag ctttgcttaa ggtgccgata acaatgtcgg 2785981 gacaaacacc aaagtattca ctcgttcctt gtcccgaatc gcccaaaact cctgttgcgt 2786041 gggcatcatc aacgaccacg aaggcatgat agcgtttcgc aagtgagatg atctgatcaa 2786101 gaggggcgat tgtgccatcc atgctgaata ctccgtctgt tacgataaaa cggcgctgat 2786161 aacgctgtgt ttcattcagc ttgttttcaa gatcattcat atcaatatgc cgataaacaa 2786221 ctgtatcagc cttagaaagt cggcagccgt cgatcatact tgcatgattg agctggtcac 2786281 ttaaaatgac atcttccttt tctggcaagg atgaaaggac accgacattg gccaagtaac 2786341 cgctcgaaaa cagcagggcc gcttctgtca gtttaaagct ggcaatcttc ttttctagct 2786401 tttcatgcca gaccgaattg cctgtcgtta aacgtgaacc gctgcttcct gtcccaaatt 2786461 gctgcaatgc tgtttgggct gcatcgatca aacgtctatc gcttgcgagc cctaaataat 2786521 tgtttgagga ccagaccgtt tgattttcgc catcaatatt cctctctgga accggcgctc 2786581 catccattga ccgcaggtta cgatgtacgc cggcttcttt cattctgtct aaccgctcgt 2786641 ttaaccagga atcaatcttc aaggctcgta acctcgtgga tcgcttgttt cataatggca 2786701 accatttccg agagctcttc agctgtgctg gcaagaggag gaagaaatgc aatcacgtcc 2786761 ccaagcggtc ttgtcagcat tcctaactct ctcattttta aggaaacttt gtatccaatc 2786821 cgccgatcag ccgggtaagg ttctttagtt tcctttgatc gtacaagctc tgcaccgcac 2786881 ataaagccaa gctgccgaat atccccaaca tgaggaagag cgtgcagatc ttgaagaaga 2786941 aaatggagct ttttactttt ttccgctact tgttccacaa tgttttcaga ttcaaataat 2787001 gccagatttt caagcgcaac cgcacagcca agctgattgc ctgtatagga atggccatgg 2787061 aaaaaggttt ttaggttttc ataatcatca tagaatgcct tatagatgtc ttcagtggca 2787121 aacgtaacgg caattggcaa atagcctcct gtaatgcctt taccggcagc catcagatca 2787181 ggctggacat tctcgtgctc gcacgcaaac atttttcctg tacggccaaa gcctgtagcg 2787241 acttcatcaa cgatcattaa gacatcgtat gttgtacata gctcgcgcac gcctgccaaa 2787301 tatccttccg gcatcacgat cataccggac gcgccttgta ccattgattc aatggaaagc 2787361 gcggcaattt cctcatgatg ttcctcaagc agctgtgcaa gctctcggag gcactgatca 2787421 cggcactcat caggatcacc gctttcagaa cgatacacat aaggaatcgg ggccttgtaa 2787481 ctctcgaaca tcaacgggcc gtatacgtgg tgaaaaagct caattgaacc gacactgacg 2787541 gcgccaatcg tatcaccgtg atacccgttt ttcattgcga tgaatttttg tttctcgggc 2787601 ttcccgatgt tcttccaata ctgaaacgcc atttttaggg ctatttccat cgcctctgcg 2787661 ccgctgtctg aataaaagac ccgcgtgagc ttttttgggc tgatgtcgat taatgtttcg 2787721 gcaagctggg ttgctggaac attggtcatg cccaataacg tggagtgcgc aatttttccg 2787781 agctgttttt ttatggcgtc atctagttct tttttgcggt gtccgtggac attaagccaa 2787841 accgatgaaa aaccgtcata gtattccttg ccgtttatgt ctttgacttt gattccagtc 2787901 ccgctttcga tgattaaggg gttttcatca taatctttca tttgggtaaa tggcagccag 2787961 aggtgctttt tacttttttc tatcaaatca tgagtcatga tcttcctccc actctattaa 2788021 aataggctgc ttctccaggt catgtatgta cgtgtttaca tcattggatc catcaataaa 2788081 aaagactcgg cagccctctt cagtcccgta ttctttcatt gctgtaatac gctgatagcc 2788141 cattttctta cccgcaacat agcctgttat gtaatccgga tcgtccgacc agcataattc 2788201 tgcaacgact gccgggtgcc ggcttacctt tgaagcgagc gcaagggcct cttttattct 2788261 tgaatgagct ggcacgtgac tgtgaagcgc ccatttttca aaattagcgt ccggccaatc 2788321 cattctggag acccgcaccc ctttttcttt tgtttgatcc attcgcttgc ctgtatgaat 2788381 atcaaacaac accgcacccc tgacatctga ccattcaggg atttgttcat atgctttttc 2788441 aatcacgtct cgtgaaacgc cttctttttc caataacaat cgggcaagct tttgtccttc 2788501 ttccgggcag ctcacttcat tcgtatgcac aggcaatggc tgaatggttt ttatcgattc 2788561 atgtacctct tcaaattgaa tttgcataaa atcaggtttt cctcttgaat gggataaccc 2788621 tttttctaat aaagcattga ctgtatgctt catctcatgg aaaggaataa gccgttctcc 2788681 gccggatata tgctttccgc cgtcttcatg agatccattc attgaagccc tcattctgac 2788741 actataaaaa gtttcttctt gcatcatttc tcgccctttc actgataact gaagaacgtg 2788801 tagcgcttct cacctaaatt gttaaccaat tatattcaaa ggttaacaat tagaatatat 2788861 tattctctcc tgtttctgtc aatagaagaa aggatcgatt tatggcagtt ggttaaaagg 2788921 aaacaaaaag accgttttca cacaaaacgg tctttttcga tttcttttta cagtcacagc 2788981 cacttttgca aaaaccggac agcttcatgc cttataactg ctgtttcgaa atgtcccgaa 2789041 gcagaacgga ccactcggta gcaatcagca gctccctgtc cagcatagac agctgtcaat 2789101 tctttttcga ttttgtccac gccctcagcc ggcgttaacc gatcgtgtac accaacaaga 2789161 ctaaggtgcg ggcgcggcgc gatcaggctt tggatctccg atgcggaaaa atgctttgca 2789221 agcgatggga cgtaataata aaagccgtgc ctgtcaagat tctgtgtttt gatcagcacg 2789281 tgatgatcca cctggctgca caaatccaca cacaccttaa tccggtcatc gagcgccgct 2789341 gtccaccacg ccatcaaacc tcccatagac atgccgatgg ttccgatcct gtcaggctga 2789401 acatcagagc gtgactgcat atagtctaac gcacttaaac tgtcataaat catcatcccc 2789461 cacatcactt ttccggtgag aagcatttct ttaaatatct cgctttccgc ttttccccgc 2789521 cgatctccaa acccccaatg atcaatcgca agaacgccgt atccgagtga agtaagctca 2789581 tcagaaaaag aaggcgtttt caaataatcc gctccctcaa tcagctcact ttttccccta 2789641 tcatactggc ctccatgcga atgctgaaac aatacggctg ggcacggtcc ttctgttttc 2789701 ttcggcttca caaaataagc gggcgccttt tcatgtccat ttaaatcgag caggagcgtt 2789761 tcaacgatat tttcttctct ttcttcaata cgtaatgtct caacactgat tggcctccga 2789821 tcaggcaaat caccaagcaa tcgaaacagt tgctttcttc tttcggctct catcccatca 2789881 cccttcctta ttcgcttact tcacatttac gagacagatc tgggttcccc tttatttttc 2789941 caacataaat cacatcattt actaaatatt tagtaaatat tatggaatat ttcgaaaaca 2790001 attattgtaa ccgcttactt ttatatgata atatcaattt atcaaaaaca gatgagttaa 2790061 tattttacta aatagatgag agggataccc atggttcgta ttaaagatat cgccttgaaa 2790121 gctaaagttt ccagcgcaac tgtgtccaga attttaaatg aagatgagtc gctttctgtt 2790181 gcgggcgaaa cgagacaaag agtcatcaac atcgctgaag agcttggtta tcaaaccgtt 2790241 gccaaacgcc gaaaatcccg cgggcaaaaa cagcgggctc agccgctgat cggtgtgctg 2790301 agctgtctgt cccctgatca ggaaaggcag gacccttatt tttcttccat tcggaaaggg 2790361 attgaaaagg aatgctttga acaggaaatt ttcattacaa attcgattca tctcggctcc 2790421 tttcaggaac atatctttcg ggaattggat ggtgtcattg tcatcggccg tgttcatgat 2790481 gaagcggtta agcatatcag cgggaggctg gagcatgccg tatttatcaa tcattcacca 2790541 gatccgcaag catacgattc gattggcatc gattttgaat cggcttcacg ccaggcgatt 2790601 gatcaccttt tcgacttagg ctacaaacgg ttaggctaca ttggcggaca agaaaaagag 2790661 catacgctga aggacggcca aagcattcgc agaacgattg aagataaacg cctgaccgct 2790721 tttttggagt cagccgcccc ccagcctgag catgtgctga tcggagaata cagcatgcgt 2790781 gagggctatc gcctgatgaa gaaagcaatc gatcaaggcc atctgccgga agcattcttt 2790841 attgccagcg attctatggc gatcggcgca ttaaaagcgc tgcaggaagc cggactgcaa 2790901 gtgccgcggg ataccgcaat cgtcagcttt aacggcattg aggaagctga atttgccagc 2790961 acgcctttaa cgacggtgaa ggtatacaca gaggaaatgg gccggacagg cgtaaaactg 2791021 ctgcttgacc gtctcaatgg ccgaacgctt cctcaacatg tcaccctgcc tacaacatta 2791081 atcgtaagac aaagctgcgg atgtacagca aaggaggtga cataagcaaa gattcatcac 2791141 gatgataagg aggaaaagat gaaacacact tttgttttat ttctctctct tattctgctt 2791201 gttctgcccg ggtgttcagc agagaaaagc tcagcagata ccgcaaaaaa gacgttaacc 2791261 atttattcta caatgtcaac cgacagtgaa agagatacgt tcagaaaact agcggcagca 2791321 ttcgaaaagg aacacagtga cattcatgtc agccttcatt tcccaggcaa tgactatgaa 2791381 aatatgatgc gtgtcagaat ggcggccaat gatttgccag atctattcga tacacatggc 2791441 tgggggaaaa tcaggtacgg agaatataca gcggatctcc gggatatgaa atggactcaa 2791501 gatcttgatc ccaatttaaa cagcatcctc aaaaataaaa gcggaaaggt gtatgcctat 2791561 ccaatcaatc aggcaaaaga cggtctggcg tataatcgca atattttaga ccgttacggc 2791621 attgctccgc cggaaaccat ggatgacttt atcaaagcac tgagaacgat taaagaaaag 2791681 agcaagggaa gcattgttcc cttctggttt gccggatatg acaaaagctc attcgcccaa 2791741 tattacgacc aattcgctac acctcttctc atcacagacc ctgcccataa tgaaaaaaaa 2791801 cagctcatca acggcacttt tcaatggagt aaattcactt atttatcaga aatcctcaaa 2791861 caaatgcaga aagaaaaatt gatcaatatc gacgccgtca cggcaaaaaa atcacagctc 2791921 attgaattaa tggcccaaaa caaaatcgcc tttacaatgc aaggcggcac actcggccaa 2791981 gacgttgccc agatcaaccc gaacgtcaag gtcggcatta tcccgacacc tgccatccat 2792041 cccggtgatg acccgatatg gatcggcggt gaacgctaca cccttgcagc atggaaagat 2792101 tcgcctcaat taaaagaggc aaaagatttt atcgcattta tggcccgccc ggccaatgcc 2792161 aaacaaatgg ctgaagccac atcgcttcct tcagggctga ccaatgtgaa agctgatatt 2792221 ttctacgcaa acgattatga gtattatcaa gatgtcaaag tcgagcctta cttcgaccgg 2792281 ttatacttgc caaacggaat gtgggatgtc ctgggcacgg ttgggcagga gctcgcggct 2792341 gacattttgg cgcctcaaga catttcgcag aagctgggaa gagaatataa acgactccgg 2792401 gagcaatccg aaacacaggg agctgaaaac aatgagtgag atcgcaaggg acgttcatgt 2792461 gaaacaggtt aagccaaaaa agcagtcctc actttggtgg atgtacattc ctgctttgct 2792521 ctccgttctg gtctttatga tttacccgtt tgtgaaaggc acattgatta cctttacaaa 2792581 ctggaacgga ttttcacaag tctaccaatg ggttggattc gcgcaatatg aaaggctgtt 2792641 ttctgatcct gatacttggc atatcttaaa aaacacgctg cattacgggc ttggcagcac 2792701 cttttttcaa aatgtggtcg ggcttctgta cgctctcctc ttaaatcaaa gcattaaaac 2792761 gaaagcggta acaagaacaa ttgtgtattt gccggtgatg atcagcccgc tcattatggg 2792821 ctacatttgg tactttttct tctcctatga cggaggcgcg ctcaacgatt tgctcggggt 2792881 cttcggcatc agccctatta atgcgctcgc cagtccctcg ctcaatccat ggatcattgt 2792941 catgattaac acctatcaat atgtcgggat cgctatggtt gtctacttag ccggtctgca 2793001 aagcattccg aaagactact atgaagcggc gcaaatggat ggcgcgaaac aaggccagca 2793061 gttttttacc atcacgctgc cgctgttaat gccctccatt accattaata tagtcatcaa 2793121 cattatcgga ggcttaaagc tgtttgacgt catcattgca ctcaccgcag gcggccccgg 2793181 aaatgcgtca caatccatgt ccacgtttat gtatgatttg tatttcaaac ggcaggatgc 2793241 cggctatgcc gcaacgcaag gcatatttat ggcatttgtc attttgatca tcagcttttg 2793301 cgcgcttgcg tactttaaaa gaaaggagac ggaaatgtca tgagagccgc ccgtacaaaa 2793361 agcatgcgga tcattacgct tcttgcagcc attgtggcct gtgcgcattt tattcctttt 2793421 tatatcctgc tgaccacttc attgaaagca aaaggagact acagttcgaa atggatattt 2793481 ccagccgaca tctcctttca taatttttca gaggcgtggg agcgcgcttc gctaggaaac 2793541 tcttttataa acaccatgat catcacaggt ttttctgcct tgttattaat tatattcggc 2793601 tcacttgccg cctacccgct tgcccggcgg gaaacgaaac tgaataaagc cgtttttgcc 2793661 ttgctgattt ccattatgat catccctccg ttaacgtcca tggttccttt gtaccgaatg 2793721 gtcgtggacg ccggaatggt caatacacac gcaatcgcca ttttcatcaa tacagcggct 2793781 tacatgccgt taaccgtatt cttatattca ggctttatcc gatcgaccat tccaaaagag 2793841 cttgtagaag ccgcaagaat tgacggtgca ggcatgctga aaatcttttt tacgattgtg 2793901 tttcctctgc tgaagccgat cactgcgacc atctgtatca tttcttgtgt ctttatttgg 2793961 aacgactatc aatttgccat tttcttttta caagatcaaa aggttcagac attaacagta 2794021 gccatggcag gttttttcgg agaaaacgca aacaaccttc atttagttgc cgcagcggca 2794081 cttatggcaa tgctgccgat ggttgttctg tttttggcgc tgcaaaaata ctttattgcc 2794141 ggcctgtctt ccggagcggt aaagggttaa cattaaaggg ggaagcaata tgaaaaagat 2794201 tacatttatc ggtgcaggga gcacgatttt cgccaaaaat gttttgggag actgcctgtt 2794261 aacagaggca ctgaatggat ttgagttcgc tctttacgac attgatccca aacgcctgca 2794321 ggaatcccag ctcatgctcg aaaatctaag agaccgttat aacccaagtg tggccatcaa 2794381 cagctatgat gacagaaaac tcgccttgca aaacgcaggc tatgtcatca atgcgattca 2794441 ggttggagga tacaaaccga gcacagtcat cgatttcgag attcctaaac ggtatgggct 2794501 gcgccagacg atcgccgata cagtaggcat cggcgggata ttcagatctc tcagaacaat 2794561 cccggtctta tttgatatcg caaaagatat ggaggaaatg tgccctgacg catggttctt 2794621 aaactataca aatccaatgg ccactcttac aggcgccatg ctccgctata ccaatatcaa 2794681 aacaatcggg ctctgccaca gtgttcaagt gtgcacgaag gatttattta aagctctcgg 2794741 aatggagcat gacggaattg aggaacgcat tgcgggcatt aatcatatgg cttggctttt 2794801 ggaagtcaaa aaagacggca cagatttata tccagaaatc aaaaggagag cgaaagaaaa 2794861 acaaaaaaca aagcatcatg atatggtgcg gtttgaatta atggataagt tcggctatta 2794921 tgtcacggaa tcgtccgaac ataacgcaga gtatcacccg tactttatta aacggaatta 2794981 ccctgaactg atcagcgagc tgcaaatccc gctcgacgaa tatccgagaa ggtgcgtcaa 2795041 gcagattgaa aattgggaga aaatgcggga tgatatcgtc aataataaaa accttacgca 2795101 cgaacgctca aaggaatatg gttcaagaat tatagaagca atggaaacaa acgaaccatt 2795161 caccttcgga ggaaacgtct tgaatacagg gctgatcacc aaccttcctt caaaagcggt 2795221 tgtggaagtg acatgcgtcg ccgacagaaa aaaaattaca ccgtgcttcg ccggagaact 2795281 gcctgagcag cttgcagcct taaaccggac gaatattaat acacagctga tgacaatcga 2795341 agcggctgtc acacgaaaaa aagaagcggt ttaccaagct gcaatgcttg atccgcatac 2795401 aagcgcggag ctttccatga aggacatcat ctccatgtgc gacgatttat ttgcagcaca 2795461 cggcgattgg cttccggaat acaaataaaa actaggggac cgctctcccc tagttttttg 2795521 gttttgtttc gccttcccag gccatcatgc cgccttcaac attgactgtt ttaaagcctt 2795581 gctcatccag gtacttgcag acgttcatgc tgcgcattcc tgagcggcag ataaatacgt 2795641 actctttgtc tttatcaagg gtttccattt tttcaggaat atcccccatg cgaatatgaa 2795701 cggcttgcgg gatcatgcct tccgctacct cttcatcttc tctgacatca attaaatata 2795761 attcttcgtc cgcctcaatt ttttctttca aagcggctgt gctgatttct tttatttcca 2795821 aagaaaacac tcctattcac agtgatcatg ttcagtatat caaagtcagc cgaacgattg 2795881 ctattctgag actgatgaaa aaaaatcccc ttttggcaaa ggggattttt tctaggctta 2795941 gtttgccaca atattgacaa gcttcccagg caccgcgatg attttccgaa tcgttttgcc 2796001 ttcaagctgc tctttgacct tttcatctgc ttgagcaagc tgttccagct gttctttcgt 2796061 tgcatcggca ggaacctgta atttcgcttt tacttttccg ttcagctgaa caacgatttc 2796121 aacttcatca tccacaagtt ttgtttcatc atatacaggc caagcttcgt aggcaattgt 2796181 gccggaatgg ccaagcttct cccatagctc ttccgctaag tgtggcgcga caggagaaag 2796241 aagcttcacg aagccttcca tatattcttt cggcagttct gttgctttat aagcttcatt 2796301 aataaagacc atcagctggg aaatacccgt gttgaaacga aggccttcat aatggtctgt 2796361 gactttcatg accgtttcat gatagacgcg ctccaatgtt tcacccgcgc cttcaacgat 2796421 ttttccatta agctcaccgc tgtcttcaat aaataggcgc catacacggt caaggaaacg 2796481 gcgcgcaccg tctaatcctg attcagacca ggcgattgaa gcatcaagag gtcccatgaa 2796541 catttcgtac aatctcagcg tatcagcacc gtgagaggcc acgatttcgt caggattgac 2796601 aacgttccct ttagatttac tcattttttc gttgttttcg ccgagaatca ttccttggtt 2796661 gtacagcttt tggaacggtt ctttcgtcgg cactacgccg atatcataaa ggaacttatg 2796721 ccagaagcgg gcatacagaa ggtgaagcac ggcatgttct gcaccgccga tatacatatc 2796781 gaccggaagc catttttcca atttttctgg tgatgccagc tgatccggat tgtgcggatc 2796841 aatatagcgc aagaaatacc agcagcttcc cgcccattgc ggcattgtat tcgtttctct 2796901 tcttcctttt ttccctgtct cagggtctgt gacttccacc cactctttaa tgttcgcaag 2796961 cggtgattcg cccgttccgc tcggtttgat ttcatccgtt tttggcaaaa tcagcggcag 2797021 ctcctcttcc gggacagctg ttgacgttcc gtcttcccaa tgaatgaccg gaatcggctc 2797081 gccccaataa cgctggcggc tgaagagcca gtcacgaaga cggtacgtca ctttcttctc 2797141 accgtttttc gtttcttcca gccaagcgat cactttttca atcgcttcct gtttgtgaag 2797201 gccgttcagg aaatcagagt tcacgtgctc gccgtcgcca gtataggctg cttcctcaac 2797261 gttcccgcct tttacgactt ccttcaccgg aaggccgaat gttttggcga attcaaaatc 2797321 acgctcatcg tgtcctggaa ctgccatgac agcacctgtt ccgtatgatg caagaacata 2797381 atccgcaatc caaatcggca gtttttctcc gtttacagga ttgatcgcat acgctcctgt 2797441 aaatacgcct gtctttgttt tcgcaagatc tgtgcgttct aggtcactct ttgattgaat 2797501 ttctttgata taagcttcaa cagcttcttt ttgctctgcc gttgtgatgt tttccaccaa 2797561 tgcgtgttcc ggggcaagga cagtgtatgt agcgccaaac agcgtatctg gtcttgttgt 2797621 aaacactgta aaggaatcat catgtccatc tatagcaaaa tgaacgtgag cgccttccga 2797681 acggccgatc cagttgcgct gcatatcttt aatgctttcc ggccaatcaa gctcttccaa 2797741 gtcctcaagg agcctgtccg cataagcggt gattttcagc atccactgct tcattgggcg 2797801 tctctctacc ggatggccgc cgcgttcgct cttgccgtca atgacttctt cgttggcaag 2797861 aacagtaccg agcgcagggc accagtttac aggcacttcg tcaacgtaag caaggccttt 2797921 ttcgtatagc tttaagaaaa tccattgcgt ccatttatag tattcagggt cagtcgtatt 2797981 gatttcgcga tcccagtcat atgagaagcc aagcgcttga atttggcggc ggaagttatc 2798041 aatattctgc ttcgtaaaca cagcggggtc gttccctgtg tcaagcgcgt actgttcagc 2798101 tggcaggccg aatgcgtccc agcccattgg atgaaggaca tcatagccct gcatgcgctt 2798161 catgcgggac agaatatccg tagctgtgta tccttcagga tggccgacgt gcaacccagc 2798221 tccagacgga taaggaaaca tgtccagcgc gtaaaatttt tgtttttcat tattatcaag 2798281 agtggcaaat gttttgtttt caagccaata tgtctgccat ttcttttcta tctctttgtg 2798341 ctgaaaactc aaagtaaaaa cctccttctg attgaatacg gcgtgtatgg ttcaagtatt 2798401 gacgggaagg agaggattat attcagaata ttcccaaact aaaaaaaact ccctcatccc 2798461 aaaaagggac gagagacttt cgttttcccg cggtaccacc ctcgttagcg cggcatacgc 2798521 cgcactcact tgatactttt aacgcagtta tgcgtcagcg gcttttcacc gctgcaactc 2798581 tgaggtgagt tcggaaacaa acttgattga ctttcaccag ccgtcaactc tctgcaacaa 2798641 tatctgtttc ttactgctcc tcttcattgt tcttatcgca accgtaatct aactgtattt 2798701 tatagaattc tgttcataag tgcaagcagg tttgtataca atgggaatgt accctgaacg 2798761 ggcggagatt gaggacaatt attcgggtgg agttttggtt tgacgtttgg actcggccgg 2798821 ttcgccgccg ctgttcagtt ctctcacaaa gtcaaaactt ctgagaacag cttcaccgcc 2798881 gtagcctgag ataatggata agatgacaag ttgaattcct gaatcggggt cagcggataa 2798941 tacaagtaaa atggaagccg tcatgccgat aaaccaatct tccaaaaatc caaggtagat 2799001 aaaccgcttc gtcattctgg gcttctccag cctgcctctc tttttcacat gaccgagaat 2799061 ccccatgatt cctccaatta cacaagcaat gagtacctga tgcagcatct tcatcatcac 2799121 cttcctaaag cccttatttc gtaaagcgac ttcaggccat ccagccccct taaacgattc 2799181 cgatgatttt cgatatctac ataccggcaa atctgtaaaa agcttgtttc ttccattata 2799241 tgtgaacaca tgatcggtaa gcttgatgca ttggattcat ttttcaccca gtgacattga 2799301 cctagtcacc tatttagcat gtagaaaacc tttccgttca tatgttcaaa ttctgttctt 2799361 atttttagtg tatacgagga caagccctaa tgacaaacaa caaactgcac ttgcttgaat 2799421 cagaacatgt gttgtgctac ggttactgta gaattcattt ttaaaaaggg gaatatcagg 2799481 ctttcgcata gcaagctgac ggcctaaggg ggatttatat ggctagtttt caatcatttg 2799541 ggataccagg acagctggaa gtcatcaaaa aagcacttga tcacgtgcga gtcggtgtgg 2799601 taattacaga tcccgcactt gaagataatc ctattgtcta cgtaaatcaa ggctttgttc 2799661 aaatgaccgg ctacgagacc gaggaaattt taggaaagaa ctgtcgcttc ttacagggga 2799721 aacacacaga tcctgcagaa gtggacaaca tcagaaccgc tttacaaaat aaagaaccgg 2799781 tcaccgttca gatccaaaac tacaaaaaag acggaacgat gttctggaat gaattaaata 2799841 ttgatccaat ggaaatagag gataaaacgt attttgtcgg aattcagaat gatatcacca 2799901 agcaaaaaga atatgaaaag cttctcgagg attccctcac ggaaattact gcactttcaa 2799961 ctcctattgt cccgattcgc aatggcattt cggctcttcc gctagtcgga aacctgacag 2800021 aggagcgatt taattccatc gtttgcacat tgacgaatat cttatcaaca tccaaagatg 2800081 attatttgat cattgattta tccggattgg cccaagtgaa cgaacaaacg gccgaccaaa 2800141 ttttcaagct gagccatttg ctgaaattga ccggaactga gttaatcatt actggcatta 2800201 agcctgaatt ggctatgaaa atgaataaac tggatgccaa tttttcgtcg ctgaaaacat 2800261 attcaaatgt aaaggatgcc gttaaagtgc ttccgattat gtaaaaagat cccgctcacc 2800321 cagctggatc tttcagattg ttgacaaaat cctaaaatgg ttttcatttt aggattttgt 2800381 catcttttca gcgtgattga aaacccttga agtctaggaa ggacgagcat aggagcggag 2800441 cgaatgttct aattcgtgag caccgaagcg caggcctgac aacgaatgcg agggtttgtc 2800501 gacacgctga aagatcccgc tcattcggcg ggatctttta ttatgaagag attgatgcct 2800561 gcttatttgt ttctttagct gattttatcc gtttgtcata tagaagcgtt gtggcaatac 2800621 tgatcagcag caataccaac agagataaaa caagagccct aatgccgtaa tgatcgacaa 2800681 gcactcctcc gaacagggga ccaatcattc tgccgcctgt cgccgcactg ttgacaaagc 2800741 cttgataaaa gccttctttc cctttagggg caagctgatt ggcaatagtc ggcacagcag 2800801 gccaaacaag catttctccg atagtcagga tcaccatcgc agcgagaaac atcggaaatt 2800861 gctttgcagt cagcagcatg ctgaaagaca caataaaaat gataaagccg atgaccattt 2800921 gcgcttttag cgactcggcc cattttttca ccacaaaact gacgagcggc tggccgagca 2800981 caatgagaat tccgttaacc gtccacagca cgctgtataa ggaaagagat attccaatgc 2801041 tttgtgtgta cgaagcaatt gtggttgacc actgagaata agccagccat ccgagtacat 2801101 agcctccgct taaaatgatc agtgcggcaa attttgcttt gctgttcaca gcatcataat 2801161 caagcacgga tgtttgggat gcatcgcccg tttgaatatt tcgaaatccg aaatatacaa 2801221 taaagaaaaa gatcagatac aatacggcat ttgccaaaaa tacatatgaa aacgagaaag 2801281 atgccacgac accgccaagc gctgaaccaa cggccacgcc cgcgttttgc gcgacatata 2801341 tcgcattaaa tgccttcctt cccccttcag gccataccga tcccgccatt gcgtagcttg 2801401 ccggaaaaac aacaccggag ccaaagccca caatcgtcag cagcacaata taggctggcc 2801461 aatcatgaaa aaagacaaga cccatcaggc ttgctaacgt aatggctatc ccaagcataa 2801521 tcgatttaaa accgccgatt ttatcaaaca aaaaacctcc gcataaattg ccagccacac 2801581 tggcgccgga attcagcatc aggacaagtc cggctactgt taacgacttt cctaaatgat 2801641 tatggatata aatcgtattc agcggccata aaaaagaagc acccgtcaca ttgataaaca 2801701 ttccaatgac taaaatttta agagcacgcg gcatactcat ccccctttct tacctaaaaa 2801761 agctcatgaa aaaaacgaaa cctaaaacgg ctccgtacga atccagttat catagcacat 2801821 tcattctatc tgtctctctc acatttttca actgatgagc gtgaaaaaat ctaacaaata 2801881 ttgtttgaaa aatgtaaaat aaatagaaaa aggggtcata ttatggaaat ggtattagca 2801941 ttcttaggtt ttctggcatg tctcattgca ctgggctatg gattatatca ccttgtcaga 2802001 tatgtactga aaaaggaaaa acgtttctca aagagacttt tttggccgct tttcattgga 2802061 ggccttgtgc tgctctttac cggggcagca ttggcagaac ctgacactgc cgcagcaaat 2802121 gccgagaaaa aatattcagc gctaaacgcc gaatataaaa acctcacaaa agagcacgaa 2802181 gaacttgaga aagaatataa atctgtcagc tctgaagcaa agaaattaaa agacaacaaa 2802241 gaagatcaag acaagcttga gaagcttaaa aacgaaaata gcgatctaaa aaagactcag 2802301 aaatcattaa aagctgagat taaagagctt caagaaaatc aaaagcagct caaagaagat 2802361 gcaaaaacgg caaaggctga aaatgaaaca cttcgacaag ataaaacaaa gcttgaaaat 2802421 caattaaaag agacggaaag ccaaaccgcc agctctcatg aagacactgg aagttcttca 2802481 aacaatacga gtaaaagtga tgaaaccaaa acagctgaca aagcagaagg ctgtaatatc 2802541 aaaggaagca gaaacggcat ctaccacacg ccaggcagta catactacga ccggacaacc 2802601 gatccggctg aaatgttttg ctcagttgaa gaagctgaag ccgccggtta tcgggcgcca 2802661 aaacgataaa caaaaagctc cagaatgtct ggagcttttt ctgtttcaca acgacgattt 2802721 aatgaccttc ttataataaa gaactgacag aaaaccaaaa atggagtaga gcgcagtata 2802781 taacaccatc accataatca taggcgccca tacctctgat ccgaataaga accagccgga 2802841 ttggacggca aagtaactgt ggaagaggcc gacaacgagc ggaatgccga agttgtacat 2802901 ttgtttgatg cgtatcccct ttatcaggtc gccctgcgta aagccgagtt ttcttaaaat 2802961 tgtatagctc ggtttttcat cttcactttc acccatttgt ttaaaataaa ggatacaacc 2803021 tgatgtaatc aggaacgtta accctaagaa gccgacgatg aacatcacca taccaaacag 2803081 tgatttttgc gcagcgcttg tatctagtct tgataaatgc tcgtttttct tgttcacctg 2803141 ttgaaaaagc tcatttgctt tttccatttg atcgtcatgt ttcacattga cgccgataaa 2803201 tgtagattgc gccagctgaa tgcgggggtc tttatccttg tccagctgtt taaacaggct 2803261 gtcatccaca atgacagcgg gcatgccccc gcttgtaaac gtgtaggaca caagaaactc 2803321 ttctcttaat cctttatatt ttaatggctg cgtctcgtgc ttgcttttta ctttaataac 2803381 accagagtcc ttgaaaacca ttattttttg cagcaagtcg gtgtatcctg agaaaacggc 2803441 ttctccagcc gccacatcga ctccttttac atctttgtcg ctaacaacag caagctgcat 2803501 attgccggga tcgccctgca tctctttcgg agttccatcc ataatatttg caatgtcaac 2803561 atttgcttgc aggacaggtg ttgccttttt tacaaacgag atgttgcttt ccctcaattt 2803621 gttttcaaat aacttggcat ctttctcatt catgaatgaa aaatcagccg ctacattttg 2803681 ttcagcggtc ttttccgacg agtaatacga gatgtaagca agagataaca gcccgatggc 2803741 gagcgctgaa acggttgtaa taatcgtcag cagcagcgca ttcgatttca ttctgaacat 2803801 gatcgaagac agtgacagaa cctcagaaat atttaagtag ccgcccttgc tttttcgaat 2803861 gatattcgag ataaacgtaa ctgatccttt ataaaacaaa aacgtcccga taatgacgct 2803921 ccccagaatg aagctcatcg caacaaacag ttcattaatg gtcttaaatt ttccgccaaa 2803981 cagctcagaa gacacatagt atcctgtcaa aatcaacacg atgcctaaag cgccgatcag 2804041 catttggaaa aatgatattt tcttcacttt gtcttcagtg gaggacgtta ctttaaacaa 2804101 agataaaata ctctgttttt tgataaacgt ataattcatg atcatgatca aaaggtaaat 2804161 gccgcagaac acaatgaccg tttggaccaa ggcctgctca gaaaaatgca gtttcgcatc 2804221 cgctttgaca tcgacaattt tgaacagaat catcaagaca agcttcgata tcgaaaaccc 2804281 ggccgctacc ccgatcgcta atgaaccgaa atacagcatg acattttctg cacttaagat 2804341 gcgaaaaatt ttatgcttcg tcattccaat taattgaaac agcccgattt ctttactccg 2804401 tctcttaata aaaatcgtat tggcatataa aatgaagatc gccactacag ccacaagcaa 2804461 aatcgaagcg gttttaatag ccgcggctcc cttgattgaa gccttcactt cgttaattgc 2804521 tggatcatac tgcagcgtga caaaggcgaa ataaagcgcc acgctaaaga tgagcgcaaa 2804581 cacatacaaa tagtaattcc ggagattctt tttcaaattt cgcaggatga gctgattaat 2804641 gttcatgctg caccccgcct aacacgcctt gcgttttcat aatatcctgg aaaaacgttt 2804701 gcctgtcctg gcccccttta ttcagctgtg tatacatttg cccgtcctta ataaaaatga 2804761 ctctgccgca gtagctggca gcgacgggat catgggtaac cataataatc gtcgcgttgc 2804821 gtttttgatt gagctggctc agcttattta atagatcgga ggccgatttc gaatcgagcg 2804881 cgccggtcgg ttcatcagcg aaaataatgc tcgggtcatg aataaacgct cttccagcgg 2804941 atgttctctg cttctggccg ccggaaattt cattcgggta tttatcccgc aattcatata 2805001 ttcccagttc cttggcaact tcctcaaact tgcgattggc ttcctttttt gatagtttcg 2805061 tgatcgataa aggcagaagg atattctctt tcactgtcaa tgtgtctaac aaattgtaat 2805121 cctgaaagat aaagcctaaa tgctgttttc taaattcagc cagctgcttt tccttcatag 2805181 ccgtcatgtc atttccatta atatgaatgg ttccgtgact gacctgatcg attgaggaca 2805241 gaacgttgag caaagtggtt tttcccgacc cggaagcacc cataatactg acgaattcgc 2805301 ccttttcaat gtgaatatcg atgcccttca gcacttcctg tttattcagc ttgtttccat 2805361 aactttttcg aattttattc gcttctaaaa tcaccattta cgcagtctcc tttatattgg 2805421 ataatctcat tataaaaagg aatgccgggc ttttccttcg atacggcgaa caaaaaagaa 2805481 aagcatgtga cattttcgtc acacgcttat gacatgttca aattgattcc gtattggaaa 2805541 ggttaatgta aaaactgttc ccgcaccaaa ctccgactca acatcaatat ggatcaataa 2805601 cggcgccgct gctttttttg ccaagtacag ccccatgcca gttgacgctt gatcatggtg 2805661 atccgttgtg gatgtaaacc ctttatcaaa aatacgcggt acatcttttg gatcaatgcc 2805721 cctgccacaa tctttcactt ggagctgcgt ctgttcccct ttttgaaagc ttttgatctc 2805781 gatttcagag gcttcgctgt atttcaccgc gtttgtcagc agctgcctga tgataaacgc 2805841 cagccatttt gcatcgctca gcacttcttt ggcctcgagc tgtatgtcaa aaccgatccc 2805901 tttttggata caccacgatt gtaaatcttt gatttcttta aagatcaaag gctgaagctg 2805961 aatgaattct actgacaggt cgttttcaat aaatgaaatg cgtttttgat gaagctgctg 2806021 atcaagaagc aggtgaatac gcagccattc atatgacagc tgggatttca gtgctttttc 2806081 ttccattcta tcaatgatta aatgcatcgc tgttaatgga gttttgacct catggatcca 2806141 tgccatcagc tcatcttttt cattttccaa tgctaagcga tgccgtgctg cggtctgctt 2806201 caagtgttct gtttgcccgg caatgcttct ttcaaccatt gcttcaaacg gcgtttccgg 2806261 ttcatttatg gctgtcacat cgagattgtt ctcccatgtt ttcaagcttt tataaaacgc 2806321 tgtttctttc cgatagcgga accaaaggaa tatgataaaa aacaagatgc acaaatacac 2806381 catataaagt acattcccaa atgatatgga aggatcgaca aaagcaatga acagcatcaa 2806441 agcctgctga aacaaaaacg cggcaatcca gctccgcctt tcgataagga atgctttaat 2806501 catagaactt gtcctcttcc ttcgcgatgt agccctggcc cacctttgtc tcgatatatg 2806561 caccaagctg cagggcgtcc agtttttttc gcaggcgatt gacattgacg gtcagcgtat 2806621 tatcactaac aaaacgctca tcgttccaca agcttctgat cagctcttcc cggctgacga 2806681 tcttgttttt ttgctctatt aattgtttta gaatgaacat ttcatttttg gtcagttcaa 2806741 cagatccttt gtcattgctg acgaggttct gctccgcgtc tacagcagcg ccgcaccacg 2806801 ttttaatcgt actcggctcc gtattataat ggtgcacacg ccggaacatc gcttggattt 2806861 tcgcgatcag cacatcaaaa tgaaatggct tttgaataaa gtcatctgcc ccgagctgca 2806921 tggacatcac catatcagca ggatgatccc gggaggataa aaagagaatc ggaacatttg 2806981 accgggagcg gatcagacgg caccaatgaa agccgtcaaa tttaggcagc tgcacatcaa 2807041 taatgacaca atcaggatta accgccgcaa attcctgcag cacctgactg aaatcctgaa 2807101 tgccgtatac atcataggac catcccgtta aacgatcctt gatttcatga aacagcgatt 2807161 catcatcttc aatcagcaaa agtttaaaca atcgactcac cgcacttttt ccttttttat 2807221 caagtgtata gcaaaacgcc agcatgcgct atagaaaaag ccggctgtct cagccggctc 2807281 gttcgcatta taattctctt ctcaacgctg tcagcacgtt ggttttggta gcttttctcg 2807341 ccgggttcat tccggaaatg actgcgaccc ctccgcaaat cacaacggca atgatcacaa 2807401 ggctcgccgg gatgtaggag aatgtgtaat tcaaatcgcc cgcatcgcca ccgcttgtgg 2807461 ccgcaagaat catcggaacg gccaggttga caaggtagct cacgccgtaa gaaatgataa 2807521 tcccaatcac acagcctaaa attccgatat acgcgctttc catcaagaac attcggcgaa 2807581 tgattgacgg gctcgcccca atcgctttca taatgccgat ctcttgcgtt ctctctgtca 2807641 ccgccatcgt catcgtgtta aaaatgccga tcgctgaaat gataactgcg atacatccga 2807701 caaagatcag tccgattttg aagaccatga agaaggtatt ggctccctca agttcagtag 2807761 tcactgatgt gacatagtac ccgtcatctg ttagatcatt tgtcagctgt tccacattct 2807821 caaacttatc agcaaaaaca ccaatgttcg tttcaacatt tccgcctttg aaatctaaga 2807881 attccgaaaa atcttttttg aattgatcac tgataaaaat atttgagtcc tccatccagt 2807941 cttgagatgg tttttttgta ataccgacaa ttttaaagtc atatgttttt gtttttgtaa 2808001 catcccctgt tttagaatct gtcttcgata cacttagttc aattgtttta tttagaatat 2808061 ctttcgtata gccctttggt tcttttatat cttctggatt tccttttgct tcctcgattt 2808121 ttttgttata ttcttccgat tcttttttcg ttaataatct ctttgcgaag tcgtatccta 2808181 ctacgatttc attttccgac tttgcgactc ttcccttttc caattccata ttggccttta 2808241 attcatcatt catattagta aaaatgagat ttgagctttc atttgtacga ttgcctaaag 2808301 tagctttgtt tggttcatac acttgcgttc tttctacaac tgaccttacg tgatcatact 2808361 tctctaaatc agctttttta atcggcttgt ctccttcctt gcccattacg ctgactttcg 2808421 ttacaatctg ctggctcatt gtcatatctg taatcgtctt ttgaatccca aatccaacgg 2808481 acgacaacac aaccaaaaac gcacacgcca ttgttgtcgc cagaatcgtc ataaagacgc 2808541 gaagcctgtt tttcttcata tttcttctga taaaatgaac ctgatcctta aacctcaacg 2808601 gtaattcctc cttttagcac accatcatga agctgaaatt ttgaatgtcc gatagaagcg 2808661 acttcatcat cgtgagtaat gatcacaaat gtaatgccac gctcacgatt cagctgctgg 2808721 atcaattcca gcacttcatg ttccgtttct gaatcaaggc ttcccgtcgg ctcatccgct 2808781 aagataatcg aaggatttaa aatcaatgct cgagcaatac tgacacgctg ctgctggccg 2808841 cctgacagtt cattcggata atgagcggcg tggttttcca gaccgacgcg tttcagcatg 2808901 tcctgcacct tttgcttccg ctcagatggc ttgattcctt ttaacgccag cggcatttcc 2808961 acattctcat acgtcgttaa acccgggatg agctgaaagc tctgaaaaat aaacccgaaa 2809021 tggtcaagcc gaaattgcgc ccattccttt tcattaaacc ccgtaacatc agtgccatta 2809081 atgacaatcc gcccttttgt cggcgatatg tagccggaaa ttaaattcaa aagcgttgat 2809141 ttccctgagc cgcttcgtcc gacaatgcag gcgatttccc ctttcgccac gctcaatgaa 2809201 acatccttca atactggaac ttcattctca cggccctttt ttccgatcgt gaaagaatgg 2809261 tcgatatgct gaacatcaat catatgttct ctctccctta caaaagtttc atttttttat 2809321 aaatcgcaaa ataactaatc aagaaaccga ttaccgcacc tgtacccatg ccaatgagat 2809381 aaccggcaaa gctctcgctt gcagtaaatc caaaatagcc gaagcccatg attcctatga 2809441 taataacgat gatctgcacc gggcggttaa gcggcttcca taagaagaaa tatccgtttc 2809501 tttcattaga cattttaaca aagctaatat agccgatgat gtaaaaaatg atagtcatga 2809561 tagccggaat gactaaataa tatggtgaat tctcagccca tttcgagtct acataaatta 2809621 tcggaatgaa atactgcacc catttaggta ctggaccatg gataaaatct attgatccgc 2809681 caaaaaggat ctcgaggttg atcacaggca ggctgatgag taaaaacggc gaaatggcca 2809741 cggtaaatga gactagaagc tgtgcgaaac tattgcctgt caaagctcct ccggccataa 2809801 ccaaagaata agccagcatg ctaacaataa tcattcccaa gctgtaattg tgaaaataaa 2809861 cggcctgatc tggcttcaaa agcatgatca gcaaaacaga caaaacataa cctatgagct 2809921 gcggcaccac aatcaccatt ccgccggtaa ggaacttcgc atgaaatatc tgccctcgtg 2809981 tatatggaag gcttaatgta aaatcaaaga agctcttgct acgttcaatc ccaagctggc 2810041 tgaccgccaa aacgactccc caaatccaaa acaatgagat aaatgagcta tttaaataat 2810101 caacgctgaa tacgcagggg ccgacccaat tttcttttcc agtgacacag ccttgataga 2810161 tgagatacat atttaaaatt gataatggat tacctaatat aaaaaccaaa atggtgataa 2810221 ctaaggcgac tttattctgc cgccactctt tgtaaagcag tccggaatcc ggcaactcac 2810281 ttccctccaa acctaaggca tttcttacac ttttgttttc ttataaatag agaagtagct 2810341 cacaaagaat ccagccactg ctccaatgat catacccaaa atataaccaa taatggaatg 2810401 tccggtatag tatccaaata aaccaaatcc aaggatgccg aaagccataa ccagaatttg 2810461 caccgggcga tctaatctgt tccataagaa aaagtgtccg ttccgttcac ttggaagctt 2810521 cttgaagctt ataaagccaa tcaagtaaaa tagcatgctc attacggctg gaatcaataa 2810581 aagatattta ctgttaatca gccattcatt tacaacgtaa ctaatcggta ctaggttcga 2810641 taaattgctt gccagagaga aataactctc aggggaaggg aatatttccc atatattcgc 2810701 accaaaaaca acttctaggt ttccaaccgg caatgcaata attaaatacg gcaatatagc 2810761 tgctgaaaac gccgttaaca gttgggcaaa agcatttcca gttaacgctc cggcggccat 2810821 caccagtgaa aaagccataa aacttatcac gattactcca atgctgctgt gctcaaaaaa 2810881 gtagacgtgt tcagggttat agacaagaat cagcagccat gcaagtaaaa agccaatcaa 2810941 ttgtgacagc acaatcacaa aaccgcctaa ccaaaatttt gtctgaaaaa tttggcttct 2811001 gttatacggg aggcttaata taaaatccat cgtgcctttc gaacgctcca ttccgaggaa 2811061 gcagaccgcc aaaatgacac ccggcaccca gttgatatct atcagattgc ttatggaata 2811121 attcacaata aaatcacaat attgcgggtc ttggcgatca agacaccctt gataagacaa 2811181 atacgtatta acgatagaaa gcggatttgc caatactaaa aacgcgatac ttaacaaaat 2811241 caccacttga ttctgcttcc actctcgata gaggagacct cggtctacca tctccgcttc 2811301 cctccaaact tcgcaatgaa cacttcttcc aggttgacag gaagctcatt ccacactttt 2811361 ggcttcagct ctctcaaaaa gctctttttc tcctcatcgc ttttcggaat cagcactgtg 2811421 taaaacacgc cggcctgatc gagcatcgga atgttttgct ctctgatggc caaattgaca 2811481 tctgtatcga aggccatttg aattttaatg tattcttctt ttaactcatc aagatccatg 2811541 acgttggtca ggctgttatc ttcaagaaaa ccaattcggt tgcacatccg ctctatgtct 2811601 tcaagccggt gggacgtaat caggatgctc gtatcacgct ctgccacttc atcgaccatc 2811661 agctgcagca catcatgcct tgtcaccgca tcaataccat ccgtcggctc atcaaggagg 2811721 atcagcgccg gtctcgccgc aaacgacaga acgagcgata gctgcttttt taagcctgtc 2811781 gacagctcac ggtatttttt cgtttccgga atttcgtatc tgttcatcag ctcattcgcg 2811841 tacgtgacat caaatttcgg atatattctt ctcaaaatat cgactaactg cttgtatgta 2811901 tacttatcgt aaaacggatt ttgaacaggc atgtagatga tattttgttt gactttcggg 2811961 tgctttttga tttctacgcc gtcaaataaa atcgttccgc tgtcagcgaa aatgatttgc 2812021 tggattaagc gaagcatcgt cgttttgccc gatccattgc gtccaagcaa tccaaagatt 2812081 tctccttttt cgattgttaa tgaaacatct tttaatactt gattgccgtc aatcgctttt 2812141 gacagctgcc gcagttcaat catttttttt gcctcccttc acatcagcgc tgatttcctt 2812201 tatccattcg tgcagttttt ccagctcaac ccctgcatag tgtgcatcga tgatgagctg 2812261 tttgagttgc tctttaatca tcgtcatctt cccttcaacc agtgtcgttt ttgcattctc 2812321 cgatatatag gtccctctgc cccgcagcgt ttcaataatc ccctctcgct caagttcttt 2812381 atacgctttg ctgacagtgt tcggattcgc aataatgatc gttgccaatt ctctgacaga 2812441 aggaagctta tcaccaggct tcatgatccc tttcaaacaa agctctttca tttgctgaat 2812501 aatttgttcg taaatgggtg ttgagcttct tggatcgatt tgaatcattt acttccctac 2812561 tttctatacg atctgaacct tttatagata aaaatgatca attatacttt tttgccattc 2812621 aaaaccgatc atcacaagaa caagaaaaaa agaacaagcg atcacagatg ccgcaatcag 2812681 cattggcacg ttacgtttgt ttcgtttttt atgtttcata actgcctccc ttaatgtcaa 2812741 tatataaatg attttatatt agtgtctata gtgtattact tcaattagta cacttaatac 2812801 aataaatact ttgactcaca aagtcaatcc tttttttaca aaaaaacgga cccttttaaa 2812861 agggtccgtt ttcctacaca tcaagagggt gctgcaggat catattattt tgcaaagatt 2812921 gaagctgaag tctcattctg tacagctgtt ctctctgctg atcatttgac gacagccata 2812981 gtttattcaa ggcatttacc gcatcttcta gctgcatttg tgcatcacta tattcttgat 2813041 cgttataatg ctcttgttta gaagcgattt tcagctgttc ttcagcataa tcataggcct 2813101 gcatacattg ctggagatgt tcatctactg attgtcttgt tgccacagta acccctcctc 2813161 ttggtaatgg aaatcatcca tcattcatat tgtagcctca tctgacttta ttcaataaag 2813221 taatttatgg tcgatattca tttgttctct tgtgaaatgc gtgctacaat tttaggatgc 2813281 aatcgtacgc aaggaggcac atgaattgtg atgcagaaca atccttttcc ttattcaaat 2813341 acggaaaaac gctatcatac attgaattat catctcagag aacatttcgg ccataaggtg 2813401 tttaaagtag cgcttgacgg cggttttgac tgtccaaatc gggatggcac cgtagcccac 2813461 ggaggctgta cgttttgcag cgcagcaggc tccggagatt ttgctggaaa ccggaccgat 2813521 gatttaatta cgcaattcca tgacatcaaa aaccgcatgc acgaaaaatg gaaggacggc 2813581 aagtacatcg cttattttca ggctttcaca aacactcacg ccccggttga ggtgcttcgt 2813641 gagaaattcg aatccgtcct cgccttagat gatgtggtcg gcatttcgat cgccacacgc 2813701 ccggactgtc tgcctgatga tgtcgttgat tacttggcag agctgaatga acgtacgtat 2813761 ttgtgggtgg agcttgggct tcaaacagtt catgaacgga ctgcactttt gatcaaccgc 2813821 gcacatgatt ttaactgcta tgtggaaggc gtcaataaat taagaaaaca cggcatacgt 2813881 gtctgctcgc atattatcaa cgggctgcct ttggaagacc gggacatgat gatggaaacg 2813941 gcaaaggccg tcgcagattt ggatgtccag ggcattaaaa tccatctgct tcacctactg 2814001 aaaggcacgc cgatggtcaa acaatatgaa aagggcaagc tggaatttct ttctcaagat 2814061 gattatgtgc agctcgtctg cgatcagctt gagatcattc cgcctgaaat gatcgtccac 2814121 cgcattacag gtgacggacc gattgagttg atgatcgggc caatgtggag cgtcaacaaa 2814181 tgggaagtgc ttggcgccat taataaagag ctagaaaatc gaggcagcta tcaaggaaag 2814241 ttctttcaac ggcttgagga ggaatcagcg ctatgatttt gaagaaaatt cttccttaca 2814301 gcaaagaact gctgaaaatg gccgcgggag agggagatat tgtcgtagat gcgacaatgg 2814361 gcaacggaca tgatacacag tttttagcgg agcttgtcgg tgaaaacggc catgtatacg 2814421 cattcgacat ccaagaatca gccgtggcca atacaaagga acggctcggt gacatgtatc 2814481 aagcgcgaac aacgttattt cacaaaagcc atgataaaat cgctgaatcc ctcccgcctg 2814541 aaacacatgg caaagtggcg gccgcggtat ttaacctcgg ctatttgccg ggcggggaca 2814601 aatcaattac gacaaacggc agttctacga tcaaagccat tgaacagctt ctcagcatca 2814661 tgaaagacga aggtctgatt gttctcgtcg tctatcatgg ccacccggaa ggcaaagctg 2814721 aaaaaaacga cgtgctcgag ttttgccggg acttggacca gcaaacagcc cgtgtattaa 2814781 catacgggtt tatcaatcag caaaatgacc cgccatttat tgtcgccatc gaaaaaaaag 2814841 ctcagatcag caaatgattt gagctttttt ctttgaattt ttcatccagg acattttttg 2814901 aaatttccgg taggctctgc cgttgatata aaagaaaagg gaggtttttc cgctggcttt 2814961 gatcagcttc tttgcgagcc ggcccatttc cttttggcct gccactttat catctgacaa 2815021 ataaacgcca agcaagccgc gattgattaa acgatggaag ttttcatgcg gaatgccttg 2815081 taaatgctcg tcggctttat ggataaagtg ttcaagccgg tccatcatct cttcatgaga 2815141 ctgataatac gagcagaaat tcaagtctcc ttccagcaag tcctcctctt gatcaatcaa 2815201 ataatcaaga agaatatgaa gaccctgtat gtaaggaaaa taactgtctc ggattttttt 2815261 agcggtgctt tctgtgaaat caggctggaa cgaatacgca accagacaga aaatgcctaa 2815321 cgttgagcct gcacaggctg aaaattcata ccattccatc tcaggcagct ctgattcata 2815381 ttgagtaaac cacttttcaa gccgcggaac acgctcatgc tcaataacgt gcttatgcac 2815441 ctgcaaatcg caataatagc cgcacagttc aagcagataa ggtttaatca tgtcatagtg 2815501 ctcaatggag ccgagaacac gctggcacgt tttaaccagt tcatgcaaat atccgctgtc 2815561 atcctgttct tccctgaatt gataatagtt ttgcagttcc gccccaactg tcagtgcgtc 2815621 ctgcattgag gcatggagca tccgaaaatc ctgcgggtcc agcgaggtgc tgcggtcaca 2815681 cagattgtcc aaataatcac taatcgtttg atacgcgatg ataaactcga cacatttctg 2815741 cttttggctg cctgacaata aggccagtat gccgccgcct tcacagtgaa acgttttgtc 2815801 ccgaatactt gcggttgcct gtgctttcaa ttcactgtta tgaatcgatt ctgatttttg 2815861 cttccatatg tccagctctt gatgaacgag cggaaaaata tctcgatata cctttgccat 2815921 caatccaaaa ggatgttccg gtactgtcaa cacatgcacc ccctactagt tcaaatatat 2815981 tgatcagtaa acgctcttgc tgctttaaaa acatcttctc tctcgggttc attgaagatc 2816041 tcatggtaaa gcccttccca ctctctgtat gctttattat gagaagcaac accattaaac 2816101 cacttgatga ccatcgtttt gtcaacaagc ttgtcatcac cggcttgcat cacaagaagc 2816161 ggaactttca aaaatgcctc tgtcggcacc attgccgatt caattgtctt taaaagctct 2816221 ctgtaccatc tgacagaaac tttcctgacg tataacgaat cattttggtc agcttcgatg 2816281 acgtcctcat tgcgcgtcgc catatcaatt gataatcccg aatcaacctt aagtgacgga 2816341 gcgatgacat tcaggccttt tgatgcaaga tcaagcgctt tattcacttt aatttgcagt 2816401 ccgagacacg gtgatgataa aataattccc gtaatccggg gatttctttg ctgtttaacc 2816461 cattcaatcg cgaccagacc gcccatgctg tgacctagaa gaaaaaccgg aagatcaaag 2816521 gttcgcgctt tatctatcca agcatctact tcatcaatgt attcttgaaa cgagcgaata 2816581 tgccctctcg ctcttgtcgt tgttccctgt ccaggcaaat cgcccatgac aacgtgataa 2816641 cccgaagacc gccacatttc aatcagccat ttatatcgtc cgtgatattc acttgccccg 2816701 tgaatgatta caatcacggc aacaggtctg tctgctttcc aggtccacat gatcttcacc 2816761 tcatacgaaa tttaaataga gaaagaagga tgaatcttat gatctaccct tataaggaac 2816821 acaagccaga tatccaccca acagccttta tagctgataa tgcaacaatt accggtgatg 2816881 tcgtgatcgg agaacagtcc agcatttggt tttctgttgt cataagggga gatgttgcgc 2816941 cgaccagaat cggaaacaga gtcaatatcc aagatttaag ctgcctccat caaagcccga 2817001 acaagacgct actcattgaa gatgacgcca cgataggcca tcaggttaca cttcatagcg 2817061 ctgttatccg caagaacgcc ttaatcggga tgggctcaat cattttagac ggagccgaaa 2817121 ttggcgaagg cgcttttatt ggtgccggca gtcttgtccc gcccggaaaa atcattccgc 2817181 ctggccatct cgcctttggc cgccctgcaa aagtcatccg ccctttgacg gaagaagacc 2817241 gaaaagatat gcaaagaata cggtcagaat atgtagaaaa gggccaatat tataaatttc 2817301 ttcaacaaac ataagacctg cttcgtctta ctttaccatt tttcaaatta tatttgaaag 2817361 caataaccat cgttaacccg gacgtcatac agttcgggtt tcgatttttc cataaaacgt 2817421 tcacatatag catgaaacgt atgactttta tcttatcaca aaactataaa cagcctctgc 2817481 aaaaacacat acctattctt tcctgttctc tattttctat gagcacacac aaaaagagcc 2817541 cactgggagc tctttttgtc agctgatatt tcgttcgctg gcagcagccg catttttttt 2817601 atgaaaccct tttccatagt acacagccag caagatgaga aaccatatcg gcccgataat 2817661 cacggctact cttgtatcag ggctgtaagc cataagaatg acgacgaatg ctagaaatgc 2817721 caatgacaca taagacgtaa acggaaataa aggcattttg tactttaatt gtttcttttc 2817781 ttccggcttc aaacttttcc tgtattttat ttgagaaagc aaaatgattg cccacgtcca 2817841 aatcgctccg aacgtcgcaa tacttgtaac ccaagtaaat accttcgcag ggacaacata 2817901 gtttaacagc actccgacta ataaagcgcc cgctgaagcc agaacagctt tacccgggat 2817961 gccgcctttc gtcagctgac catatgcttg tggcgcctct ttctgttccg ccaagttaaa 2818021 cagcatccgc cctgtgctga aaataccact gttgcatgaa gacagcgcgg ctgtcaacac 2818081 gacaaagtta atgatacctg cggccgatgg aatgcccact ttttgaaatg tgagaacaaa 2818141 tggacttcct tgagagccaa tttcctgcca cggataaata gacataatga caaataaagc 2818201 gcctacataa aaaatcaaaa tccgccaaaa tactgtatcg attgctttgg ctaacgattt 2818261 ttgcgggttt tttacttcgc cagccgtcac cccgatcatt tcaatcccta aataggcgaa 2818321 catgaccatt tgaagagaca ataaaacccc ttttaatcca tgagggaaaa atcctccgtt 2818381 gttccacaaa ttgctgattc cggttgcaat gcccccattg ccgactcctg caataatcat 2818441 caataaaccg acagcaatca tggataagat tgcaacaatt ttaatcaatg cgaaccaaaa 2818501 ttccagctcg ccgtaagctt tgacagccag gaaattaaca cccgtcataa tgaccagtgc 2818561 cgataacgcc caaatccagt ttggcacgtc cggaaaccag aaccccatat agatgccgac 2818621 agcagtgatt tcggccatac aggtgacaac ccataaaaac cagtagttcc aacctgttaa 2818681 atagcctgca agcggtccca aataatcacg cgcatacctg ctgaaggagc ctgcgaccgg 2818741 tttttgaatg gccatttccc caagcgctct cataataaaa aacatgacca ggccgcttgc 2818801 ggcatacgct accaaaatac caggccctgc taattgaata gctgatgcgg agccgaggaa 2818861 caaccctact cctatagcag ctcctaaaga cattaaagaa atatgccttt cttcgagtcc 2818921 gcggtgcagc tcttgttttt gtttttgcat gcttcttctc ccctagaaaa aaatatcatt 2818981 atatcatttt tctgaatatt ccgtacggat tgggtaaatc aatgatgatg gagaaataaa 2819041 aggataacaa caaggctttc gactactcga aagccttgtt gtctgttaca caaagatgac 2819101 ttctttaggc tgatggctca gctcttcagg catataccgt ttttcaatat tgatgctgtg 2819161 ccagatcata aagattagca cagtccaaat tttacggctg ttatcagcct tgtccgcaca 2819221 atggtcttca agaagctgaa ggacataatc cttatggata taagcatccg tttggctttc 2819281 ttgaataata ttccgcaccc attcgttcat ttcgtttttc agccaatgac ggatcggtac 2819341 agggaaacca agctttttgc ggtttaatac gtgctcaggc acaattcctt cagcggcttt 2819401 gcgaagaaga tacttcgtcg tgccgttctt cgttttcagc tcatcaggaa tttttgaagc 2819461 gacgtcgaat acgactttat ccaagaacgg cacacgcagt tccaaagaat tcgccatcgt 2819521 cattttatcc gcctttaaca aaatgtcgcc gcgcatccaa gtgtggatat cgacatactg 2819581 cattttgttg atatcgctgt acgagctgct ttctgtaaag taagtcttcg tcacatcgcg 2819641 atatgaaagg ttcggattat aatgcttcaa cagctgcttt ttgacagact cttcaaagat 2819701 tttcgcgtta ccgatataac gatcctgaag cggagtgcag ccgcgctcaa gcaggctctt 2819761 ccctctcata ccttcaggca taacggcagc aacgtgcaga agcatctttt tcaagccgga 2819821 cggaatccgt tcaaacggtt taagcgaaag cggttcacgg taaatgttat atccgccgaa 2819881 gagctcatcc gctccttcac ctgataaagc aaccgtaaca tgtttttttg cttcttttgc 2819941 aacaaagtac aacggaatcg ctgccggatc agcaagcggg tcatcaaaat gccatacgat 2820001 cttcggaagc tcattcatgt attcctcagg cgaaatgact ttgctgatat tttcaatgcc 2820061 cagcgccgct gccgtttctt tcgctacatc aacctcactg aagccctgct gttcaaagcc 2820121 gacagagaat gtttttaagc ttggatgaaa ttccttcgca acagacacaa taaaggaaga 2820181 atcaatcccg ccagacagga acgaaccgac aggaacgtca cttctcatat gaacgtttac 2820241 agagtcatag atcgcgtctc ggacttcttt cacaagcttg tcttcttcag tctgaaccgg 2820301 cttgaagttc gctttgaaat acgttttgaa tgtgatatcg ccgtccgggc ggattgtgaa 2820361 ttgtgaaccc ggctctactt ttttcacatg ggcatcaagc gtgcttggtt caggaacaaa 2820421 ttggaaagac atgtactgct gcaatgcctc tttatctatt tcaatatcat tctgagcaac 2820481 cattaaactt tttctctctg aggcaaaata aacctgatca ttgatcgttg tgtagtacaa 2820541 cggtttaatg ccgaatggat ctcttgcccc ataaagcaca tgatcgtttt tattccaaat 2820601 cagaaaggca aacataccgc gcagtttgga cgccgcttct tctttatagt gacggtaagt 2820661 cgcaagaaga acctctgtgt ccgaatccgt gttgaatgtg tacccctttg cttcaagttc 2820721 ttctctcagt tcgatatagt tatagatttc tccgttaaag ataatccaat atgtttcatc 2820781 ttcatatgat aaaggctgtc caccattttc tacatcaata atgctgagcc gtctgaatcc 2820841 gaagccgacg tgctcatcat ggaaatatcc atcactgtca ggaccgcggt gaacgatcat 2820901 ttggttcatt tgtttgatta gttcttcttg atcagcggtt tgagctaacg gatgcttgtt 2820961 aaaaaccccg acaaatccac acatagtatt gcctccataa ttaaaattgt catcattgaa 2821021 cccctattta tagacgctgt gaatagtatt tggtttcaca gttatgtaaa aaaataaaca 2821081 tgaatacaac gataaaaaag ggaaagccgc ttaaccagta agcggctata aaattattct 2821141 cctaacgctt ctttacgcag ctgctccgct ttgtctgtgc gctcccatgg aaggtcaaca 2821201 tcgtgacgtc caaagtggcc gtacgcagca gtttgtttat agatcggacg gcgcaaatca 2821261 agcattttga taatgccggc aggtcgtaaa tcaaagttat tgcgaacaac ttcaatcagt 2821321 ttttcctcag aagcttttcc tgaaccgaat gtgttgattg agattgacac aggctgtgca 2821381 acaccgatcg cgtaagcaag ctgtacttcg caagaatcag caagctcagc cgcaacgatg 2821441 tttttcgcaa cgtatcttgc cgcataagct gcagaacggt ctaccttcgt cgcgtcctta 2821501 cctgagaacg cgcctccgcc gtggcgtgca tagccgccgt acgtatcaac gatgattttg 2821561 cgtcctgtaa gtcccgcatc cccttgaggg cctccgatta cgaaacgtcc tgtagggttg 2821621 atgaaatatt ttgtttcttc atcaatcagc tcttcaggaa caaccggatt gattacatgt 2821681 tctttaatgt tgcgctgaat ttgctcaagt gtaatttcag ggtgatgctg agttgaaata 2821741 acaatcgcgt caatgcggac tggtttgtta ttttcatcgt actcaaccgt tacctgtgtt 2821801 ttgccgtcag ggcgaaggta cggaagaata tcttctttac ggacttcact taggcggcgg 2821861 gctaatttat gggcaagtga aattggaaga ggcataagct ctttcgtttc gttgcacgca 2821921 taaccgaaca ttaatccttg gtcacccgca ccaatcgctt caatttcttc gtcgctcatt 2821981 gtgccttcac gggcttcaag cgcttggtct acgcccatcg cgatatcagc agactgctca 2822041 tcaattgatg ttaaaaccgc acaagtttcc gcatcaaatc cgtattttgc acgtgtgtat 2822101 ccgatttctt taatggtttg gcgaaccgtt ttcggaatgt caacatacgt agaagttgtg 2822161 atctctccgc ttacaagaac caaacctgtt gtcacagatg tttcacaagc aacacgcgcg 2822221 ttagggtctt tctttaaaat ttcatctaaa atgctgtcag aaatctggtc acagatttta 2822281 tccggatgcc cctccgtaac agattctgat gtaaataaac gacgattttt actcatgatt 2822341 tgcttcctcc tgcacaaggc ctcccgaaag accttgtata tatgatacgg aactcgctcc 2822401 ctcttataca atgtacagtt atattagaga atgttaattg gcatatttat gaaataaaaa 2822461 aaccttttcc atcgaggaaa gggtttggtc tttgtgcctt tcactcttat cgctcaagga 2822521 atcatacaac cttgcaacag gttagcacct tggttgtctc actcagttga acataataaa 2822581 taacagagaa accggttgct gggcttcata gggcctgtcc ctccgccagc tcgggataag 2822641 agtatccgct caatgaaata tcttatcgta aaagggtttg caatgtcaat atgattcaga 2822701 agaaataggc acctatattg agggaaaaca atggaaatgc acacacaaaa aacaataaat 2822761 agtatagact atttgaaaat atatgttata ctaattcaca attagcaaaa cacaaaaaac 2822821 gataaaggaa ggtttcatat gaactcagtt gatttgaccg ctgatttaca agccttatta 2822881 acatgtccaa atgtgcgtca taatttatca gcagcacagc taacagaaaa agtcctctcc 2822941 cgaaacgaag gcattttaac atccacaggt gctgttcgcg cgacaacagg cgcttacaca 2823001 ggacgctcac ctaaagataa attcatcgtg gaggaagaaa gcacgaaaaa taagatcgat 2823061 tggggcccgg tgaatcagcc gatttcagaa gaagcgtttg agcggctgta cacgaaagtt 2823121 gtcagctatt taaaggagcg agatgaactg tttgttttcg aaggatttgc cggagcagac 2823181 gagaaataca ggctgccgat cactgtcgta aatgagttcg catggcacaa tttatttgcg 2823241 cggcagctgt ttatccgtcc ggaaggaaat gataagaaaa cagttgagca gccgttcacc 2823301 attctttctg ctccgcattt caaagcggat ccaaaaacag acggcactca ttccgaaacg 2823361 tttattattg tctctttcga aaagcggaca attttaatcg gcggaactga gtatgccggt 2823421 gaaatgaaga agtccatttt ctccattatg aatttcctgc tgcctgaaag agatatttta 2823481 tctatgcact gctccgccaa tgtcggtgaa aaaggcgatg tcgccctttt cttcggactg 2823541 tcaggaacag gaaagaccac cctgtcggca gatgctgacc gcaagctgat cggtgacgat 2823601 gaacatggct ggtctgatac aggcgtcttt aatattgaag gcggatgcta cgctaagtgt 2823661 attcatttaa gcgaggaaaa ggagccgcaa atctttaacg cgatccgctt cgggtctgtt 2823721 ctcgaaaatg tcgttgtgga tgaagataca cgcgaagcca attatgatga ttccttctat 2823781 actgaaaaca cgcgggcagc ttacccgatt catatgatta ataacatcgt gactccaagc 2823841 atggccggcc atccgtcagc cattgtattt ttgacggctg atgccttcgg agtcctgccg 2823901 ccgatcagca aactaacgaa ggagcaggcg atgtaccatt ttttgagcgg ttacacgagt 2823961 aagcttgccg gaaccgaacg tggtgtcacg tctcctgaaa cgacgttttc tacatgcttc 2824021 ggctcaccgt tcctgccgct tcctgctcac gtctatgctg aaatgctcgg caaaaagatc 2824081 gatgaacacg gcgcagacgt tttcttagtc aataccggat ggaccggggg cggctacggc 2824141 acaggcgaac gaatgaagct ttcttacact agagcaatgg tcaaagcagc gattgaaggc 2824201 aaattagagg atgctgaaat gataactgac gatattttcg gcctgcacat tccggcccat 2824261 gttcctggcg ttcctgatca tatccttcag cctgaaaaca cgtggaccaa caaggaagaa 2824321 tacaaagaaa aagcagtcta ccttgcaaat gaattcaaag agaactttaa aaagttcgca 2824381 cataccgatg ccatcgccca ggcaggcggc cctctcgtat aaaaaacaaa agccaagagc 2824441 aattatgctc ttggcttgtt ttaattgacg gaatgcaaag aagtcagctt gtatgtaatg 2824501 atggtccggc cttcttccca ttgaagcttc tgcacttcag ctgtgcctga cttttcgcca 2824561 aactttgttt tgcgtacatc cattggaatc tccatcggat atactcggta tccgtccttc 2824621 tctaacgtga atatattttc atctatgcga acttcttttc cttttgtcac aatcagtgta 2824681 ttaaattcaa caggcattcc caaagtgaaa tcccctttcg ttctcttttt tctttatcat 2824741 aacatatttc actgtcagcg gtttttcatc cattgtgtga gctgccgcac gatacgccgg 2824801 ttttcttttg gcgggaaata atgtgtgaat gtactgtagt accatgtttc caccggctta 2824861 tgcagttgtt ttagcttctc ttctaataaa taggaatgct gaatcgaaac attttggtct 2824921 ttttctccat ggattaacag cacgggagcc tgaattttgt ttacttggtc aaacggtgtc 2824981 ctccattgat attcctcagg cacctttttc ggtgttccgc cgatgactct tttcatcatt 2825041 cgccgcaaat cctgccgctc ctcgtatgta agaatcatat cactgacgcc tccccaggaa 2825101 acaaatgaag ctgcctgccc gcccatttcg atcgcagtga gcattcccat aattccgccg 2825161 cgggaaaaac cgaagatatg gattctatcc ttcttgacat ttgggtgctg ctgaagcagg 2825221 cgaaaagcag aaaatgcatc ctccctgtct tctccggcaa aatcctcatt gccttctcct 2825281 ccttgattgc ctctgtaaaa aggagcaaac accacaaacc cttgggatgc aaactggata 2825341 atccggcccg gccgaaccat gcccacgctt ttaatcccgc cgcgcaaata taaaaatccg 2825401 tcatattgtc ccggttccgc cggctcagcc agaagcccct taacccgtaa tccatttgac 2825461 agatagcaga tcgtatacaa acgcacatgc tggcttggcg acggaaatct tcttttctct 2825521 acaatcaaaa cagccgcctc cttttttcta tatgctttcc ttactccaaa attacatccg 2825581 gagaacctgg ttaggcattc acacattttt atacccatca tacgatatgt aaagcaaaaa 2825641 aggatattaa cttgatgcga aataaggagg ttgtctatgt gaacagatgg ttaaggctgg 2825701 gcttcgcctg tgtcggcagt atctttctga tgttcgccct ggcggcttgc aagcaggaag 2825761 aaacgctcac caaagtcaaa gtagctgaag tgacccattc aattttttac gcacctttat 2825821 atgttgctga gtctaaaggt ttttttaagg aagaagggct tgatgtcgat gtgaatacga 2825881 cctggggcgg agataaaacg atgacatcgc ttctttccaa cggctccgac atcgcgcttg 2825941 tcgggtcaga aacatctatt tatgtcgaag cgcaaggggc taaagatccc gtcattaatt 2826001 tcgcccagct gactcagaca gacggaacgt ttcttgtcgc gagagaagat gttgaacact 2826061 tcgactggga tcagctgaaa ggaaaaacgt ttctcggtca gcgaaaaggc ggcatgccgc 2826121 aaatggtcgg cgagtatgta ctgaacaaac ataagattga cccgcataag gatatagacc 2826181 tcatccagaa catagacttc gccaatattg ccaatgcgtt tgcttctgga accggtgagt 2826241 atgtacagct ctttgaaccg caggcttctc tctttgagaa aaaaggcatc ggccatatcg 2826301 tggcttcatt cggagaagaa tcaggagagg ttccttatac gacttttatg gcgaaacaaa 2826361 gctatttgaa gaaaaatgaa gacacagccg tcaagtttac aaaagccatt tataaggcgc 2826421 agcagtgggt tgaaaatcat tctgcgaagg acatcacaga tgccattaaa gatgaatttg 2826481 atgataccga cccagacgtc atcgaaacat ccattgaacg ctataaaaaa cagcattcat 2826541 attcaccaga ccctctgctt aacgaaaaag aatgggagct tctccaaacc attatggata 2826601 aatcgggaga actgccgaag cacattccat acaatcagct tgtaaataaa gaaattgctg 2826661 aaaaagtcac ctcggagaaa taggaggcgc catctatgtc tttcttacat gtcgaccatg 2826721 taacccatac ttatttttct attaaagaaa aaacaacggc tgtgcgggat attcatttcg 2826781 atgccgaaaa aggcgatttc atctcatttc tcggcccaag cggctgcgga aaaacaacat 2826841 tgctttccat tattgccggt ttgattgagc catcagaagg cagagttctg attgaaggcc 2826901 gtgagccgaa tcaaaaagaa cataatattg gctatatgct tcagcaggat tacttatttc 2826961 cctggaaatc tatcgaggaa aatgtgcttc tcggtttaaa aatcgccgac acgctgacag 2827021 aagaaagcaa agccgctgca ctcggtctat tgccggagtt cggcctcata gatgtggaga 2827081 aaaaatatcc gaaagaactg tcaggcggga tgcgccagcg ggctgcgctt gcaagaacac 2827141 ttgcgcctaa ccctagtctg cttttgctgg atgagccatt ttccgcgctt gattttcaga 2827201 caaagctgtc tttggaaaac ctggtattcc gcacattaaa ggaatatcaa aaaacagcag 2827261 tgcttgtcac tcatgatata ggggaagcga tagcgatgag cgatacgatc tttttatttt 2827321 caaatcagcc gggcaccatc catcagattt ttaccattcc taaggaattg gccgcgatgt 2827381 tgccttttga cgcccgtcag gaaccttcct tccagacact gtttcaaacg atatggaagg 2827441 agctgaattc tcttgagaaa cagcaaagaa accattgatc tgcttcacga gcagtatcaa 2827501 ttcaaacaga aaaaggaaaa gtggaaggtc cattcctttc agcttgccat atttattctc 2827561 tttttctcgg gctgggaaat ctccagcagg cagggctgga tcgatccgct gatcttcagc 2827621 tctccatcag ctgtgtggcg attattgctg gagaaacttg gtgacggttc tttactgtca 2827681 cacatcggcg tcactttatt tgaaacggtg cttggctttt tgctcgggac gtttatgggc 2827741 acgtgcctag ccgctttgtt atggtggtct aaccgacttg ccagaatttt agatccgtat 2827801 cttgtgattt tgaacgcaat gccgaaagtg gccctgggcc cgatcctgat tgtcgcgctc 2827861 ggtcccagtt ttatcagcat cattgcgatg ggagccatca tcagcgtcat tatcacaacc 2827921 atcgttgtct acaccgcctt ccaagaggtc gacgaaaact atacgaaagt catgaaaaca 2827981 ttcggcgcaa aaaagtgggt tatttttaaa gaagtcatac tgcctgcatc ctcccccgcg 2828041 attatttcaa cactaaaagt gaacgtcggt ttatcatggg ttggcgttat tgtaggggaa 2828101 ttcctcgttt cgaaggtcgg attaggatat atgattattt acggattcca agtcttcaat 2828161 tttacactcg tcttcttaag cctgctgatc atcgccatct tcgccactct gatgtatcag 2828221 ggcgtcgagc tgctggaaaa gaaatggacg aaggggagga cataaaaaac ccggcacatg 2828281 tgccgggttt tttattcaat ccatccagat tctttcagtt ttttcaagct gatcggaaga 2828341 acggaatcct tcataataaa gctgaatttt ttattgcggg aaaggttctc cggcagctcg 2828401 tgaaacaaaa ccgggccttt cgtttcaaag taatcagcct gcttttcaag cttttctata 2828461 tctgcaaaat atatattttt tacaatcact ttttcttttc cgagaacttt atactgtccg 2828521 agatacttga ggcttttgac tctcgcgccc gtctcttcct ttacttcccg gagcgcagcc 2828581 tcttctgcgc actccatcgg ctctactttc ccgcctggaa actcatagcc tctgtcctca 2828641 tgttctgtta aaagccattt gccgccaaaa cggcaaatca cccagacatg cttcgggctg 2828701 tccgagaaag gctgatcgtc aaaggaaagc tgaacagtat tctgataata atctttaaac 2828761 tcgtacatgt ttatccctca aatccgttcc tagctatctt ccatacatca taccacagtt 2828821 acgtttcttc ggaagccttt tatcaaaaaa taagggaaac ccagcacgcc gtcaggttct 2828881 gcatgcagac tagctcgtac agtttttttg cgatactttt gccggaaagt gcgaccgacg 2828941 ctctgggctt tattatgacc cgcgaacagg gaaaagttac ggtttgcgct taaatttatt 2829001 ttttaacgtt tctaaaagat cgacaagcat ctgaggaacc ggtatgccaa gagagctggc 2829061 tgtcacaaca atttgcacag attcataaag aatataaaac ataatagcca agtcacgaat 2829121 tgatccctgt gtattcagca gctgatcaaa aaagtggcat acagagatca gagccagcgt 2829181 gactaatttt ttgacaagcc gggcaaatac ctttttaaat gacagtttgt gaataatggt 2829241 ttccttcaaa gtcgtactga taaattcaat tgccataaga gagagcaaaa tcagaaatga 2829301 atactgaaaa cctccaaaga aaaaacccgc tgctgaaacg ctgactgcta aaaacgaaaa 2829361 gatgccaaag tctctatcca tttatcccaa catcctttca cagaaacggc cttacgatat 2829421 tctatggtaa acaagccgaa cggattggat ttttcagaaa aatggactgg ttgtcgccta 2829481 tttttcagat acaaaaagaa aagccggacg tcttttttaa gacatccggc cgttctattt 2829541 ttgaacttaa cctaggtaag cttttagcat ccagttatgt ttttcaatat tttgatggat 2829601 cgcaagaagc atgtcccctg ttgtttcgtc accgacttca tcagctaaat ccatgccgtt 2829661 tttcagctct tccgcgatga ctgtgaaatc atcatatacg ctttgaacca tttgttcagc 2829721 tgtttcattt ccagcagctt ctttgacaga agccgtttct aaggattcct tcattgttgc 2829781 aatcggtttt ccgttcagcg ccaaaagacg ttctgctaag tcatcaatat aagttgctgt 2829841 ttcgttgtac agctcctcaa acttttcatg aagagtgaag aaatctttcc ctttcacata 2829901 ccagtgataa ttatgtagtt tcacatacat gaccgtccag ttggctactt gtttgttcac 2829961 tgcttgaatc aattgttctg acatggtatc tcctccttgt tatatgacta tgtataccct 2830021 taatatcgta cgctaaaacc tcttttttac ccttatctgt cacgatttct tctattatgc 2830081 tacaattgtt aaaaaacggg aggtggaatg tcatgacgct tctcattacg ataagtattt 2830141 tgattgtgct ggctgttttg cttgtaacca tttggacgac tgtaaaagcc tataatgtaa 2830201 agcataccat tgatccacca caagaaaatc actctgattc acacaatcaa tgatgatgtg 2830261 aatgctcctc ttctgactga ttgctggcag catcggcgtc tccgacttgg acttttaagg 2830321 tcggcatgct atgctgtttt tttgctgtga catgagattg gacagtgtat acaccatctt 2830381 ccttaaacgt cgtttccaat cggtatacgc ctttttcttg tttcacctta aacatttggc 2830441 ttgcgtcttt ttccccttct ttccatactt caaactctac ttcatcggca tccgtcacag 2830501 cttcatcacc atatgataca gctgcttcat aagcagcgct ttctccggga tttacttttt 2830561 caggcccggt cagcttgaca tccaaaacct cgggcgtctc agctgtattt gctttacttt 2830621 caccagatcc gcatccatta agcaataaag cagaaaaaag cagaacaacc aacatctttt 2830681 tcatgccatc accctttcat cgtttaccta aatagtagca aacgcttaca gcaaatggta 2830741 cacaaaatat gagacgtcac aaaaaagacc tttttgctta agcgcaaaaa ggtcctttct 2830801 attttagcca aatactttta gcaattcttc tttatcctgt gaaagccaga aacgcattaa 2830861 acgtttagcg ccttccagat catgaagctt cgcttggccg cactgctttt cattcgcagc 2830921 aggtatttct gtaatctcta ccgcttcctt cattgtgtct tcaagcagat caacgatttc 2830981 cgctgatgtc ggctctccgc tcacaactag ataatagcct gtctggcagc ccattggaga 2831041 aatatcaatg atatcaaaat gatcgtattt ctcagcgtga gaacgaatcg taaacgcgag 2831101 caaatgctcg agtgtgtgaa tggtgtcagg cttcatcgcc tgtttatttg gctggcaaaa 2831161 acgaatgtca aatttattta caacgccgtc tgttcccact ttatgcacgc cgcaatgtct 2831221 tacatatgga gcaacaaccg cattatgatc aagctcaaaa ctttctactg aaggcataat 2831281 ggcactctcc ccttttttaa aaatgtaatt tcattataac atacttttcc gataagaatt 2831341 attgattaac ttttcaatct gtgttttttt tcttatactt gcatcagaaa ggttgctgaa 2831401 gaaacatgaa aaccctattc atcgctctga tcagaggata tcaaaaattc atctcgcccc 2831461 tgacaccgcc aacgtgccgc ttttatccga cctgttccca atatggaatc gaagcgatta 2831521 aaacacatgg cgctttaaaa ggcggatggc tgacaatcaa acggattttg aaatgccacc 2831581 cgttccatcc gggaggagtc gatcccgttc ctgaaaagaa acaaaaacat taattgttat 2831641 aaccgtttac gataagatcc agttttccgg ttttaggatc aatgactaag ccatggaccg 2831701 gaacgttttc agggaacagc gggtgatgtt taataacatc tacgctgtct ttcacactcg 2831761 cttccactga atcaaagctt ttaaaccatt gatcaaagtc tacaccggag tactttattg 2831821 tttcgatgcg ttcttccgga atccctcttg ctttgatttt ttcaagcatg cttttgctgc 2831881 tgattttgct catgccgcaa tcgtgatgcc cgatcacaca cacctcatct gcattcagct 2831941 cgtacactgc gacgagtata cttctcatga tgcttccgaa tgggtgtgtc acaagcgcac 2832001 cggcactttt aatgattttc acatcaccgt ttcgcaaatt catcgcatgc ggcagcagtt 2832061 caaccagacg agtatccatg caagaaagaa tcgccatttt tttatctgga aattttgatg 2832121 tttgatactt ttcatactct ctttgttcag taaatgtctt gttaaattcg agaatatcat 2832181 ttagaagact catgttcgtt gtccctttct attcttttta ctcttcaata tatcacaacc 2832241 cttgtttatt cgtcataata aaaaaagaca aaccctcagg cctgccttat ttccccatgt 2832301 tatagcgttt tttgaactgc tcaactcgtc cgcctttttc attgaatttc tggcggcctg 2832361 tataaaacgg atgcgtgtca gagcttacct ctactttaat gacaggatat gtgtttccgt 2832421 cctcccactc tgctgtttca ttagatgttt tcgtagaggt gcttagaaaa cggtagccgc 2832481 tgttgacatc ctgaaatatc actttgtggt tctttggatg aattccttct ttcatgggta 2832541 tctcctttca ataaatcgta ataattacgt tttattttat aaccttacaa acgttttgtc 2832601 aatcttctta tatccttccc tctgtttcac atcgtaaacc tcatggcatt taagaatagg 2832661 aagaataatc taaccgagga agcaaataat aaacccaaaa tacatacaga acgtcttttt 2832721 ggaaaggtgg tttacgattg tggatgattt agttttggcc agaagccttt ttggcacgac 2832781 gatgggcttt catatcattt tcgcaacact tggagtcggt ctgccgctca tgattttagt 2832841 ggcggaattg atctatcaaa aaacgaaaga tgaccattat gcgatcatgg cgaaaagatg 2832901 gacgaaagca caagccgttt tgctgggggt cgccataccg accggaacga tcgcgggcac 2832961 tcagctcgcg cttttatggc cgggatttat ggaagtcatc ggccgggtga tgtccctgcc 2833021 atttcaaatt gaaatctatg ctttttttgt tgaagcccta ttcatgtcga tttatgtata 2833081 cgctgcagac cgtttgtcac ctgcaatgag gattgttgct gttttctttg tgttagtcgg 2833141 ggcagcagca tccgctgttc tgatcacgaa tgttcacgct tttgaaggta cgcccgccgg 2833201 ttttaaaatt ttaaacggaa aaattacaga tgttgacccg tgggctgcgt tttttaatcc 2833261 tagctttttt atcactgccg gccatgtcgt gctgtccgcg tttatgactg gtgcgtttat 2833321 cgtggcttct gttgcggcgt ataaaatgat ccgaacgagg aaaaaggaaa gggtctatcg 2833381 ctttcaccgg aaagcccttt tgctcgcact gacgatcggc ggtatttttt cattgctgac 2833441 cgctttgaac ggacacgaat ctgcacagat gctgtacgaa taccagcccg aaaaattagc 2833501 cggtgcggaa ggcctatttg aaacaagatc ccacgccccg ctcgctatcg gcggttttac 2833561 cgacccgaat gaagaaaaag taaaatgggc aatcgagatt ccatgggctt taagcttttt 2833621 ggcagcgaac cgttttgaca ctgttgtaaa aggattaaat gcatttccga gagatgaatg 2833681 gccgccgctt ttcattcaca cgctgtttaa tgcgatggtt ggtgtaggca tgctgctaat 2833741 tctttattcc attatcggtg tggtctggag aaaggtgctc aagaaagacc gtttcccaac 2833801 gtggcttttg atcattttca tgacagcagg cccttttagt ctcatcggca ttgaattcgg 2833861 ctggattttc gcatgtacgg ggaggcagcc ttgggtcatc tatcatctgc tgaaaacgtc 2833921 agatgtcgta acaacgactg gctcgatcgg ggtgctgttc ttatttttca catttgttta 2833981 tgccgtgtta ggcgcagctg tcgtctacgt gctgctgtat tatttccgca agcacccggt 2834041 tgacgaagat ttaaatacag cggagtcgta atggctccgc aaacaggaaa ccaaatggaa 2834101 ggaagatcgt acaaatggag atttcaactg acgctctgat cgccatctca attatctggg 2834161 gctttgtgtt tatttacgcc gtcatggcga caatggattt tggagcggga ttttggtcta 2834221 tgatctattt aaacaaggag catatgaagg ccaccgatat tgcgaatcgc tttttgtccc 2834281 cgacttggga ggtcacaaac gtctttattg tggccatcgt cgtggcgctt ttcagttttt 2834341 tccccggcgc gacatttgtg ctcggcaccg ttttattaat tcccggaagc atgattttgc 2834401 tgcttttagc aattcgaagc ggatttctcg tgttttcaaa tacagcaaag gagcggaaaa 2834461 cgctaagata tatttccggc atctccggct ttatcattcc tgctatttta attttggtgc 2834521 ttcctgtgac acacggaggg tttatagaaa aaacggatgg aatctataac ttaaatatgt 2834581 ctaaaatctt ttcaagcccc aacgcctatt catttatcgg gtttgcgatt ttaagcacct 2834641 tatttttgtc ctcgctgttg cttgcagatt tttcaaatgt ggcagaggaa caggatgcgt 2834701 accgagccta cagaaaaagc gccctgatta ccggcccgat ttcactgttg tttgctgtat 2834761 gcattatggt aactatgcgg aatgaagcaa actggctgta cagcggaatg atgaatgatt 2834821 tttcttggat tattgcatcg ttcattacat ttgtcattgc tggaatcgct ctttttctgc 2834881 ctaacaaaag ctttggtcaa aacatcggaa aaccgcgtct cgcacttgtt gcgattggga 2834941 tacagtattt tctcgcaagc tacgcgtacg ggcgggcgca tcttccgtat atgatttatc 2835001 ccgatgtgac agtcatgtca ggcttcacag agccagcaac gttcagagcg ctgtttgcaa 2835061 cgtatatcgt tgcatttatc attctatttc cgggcttctt tttcttctgg aaaatgttta 2835121 tgcgagataa acgctatatc cgccaggagg aatagagggc aagccagccg gctatactaa 2835181 tccagaacct ttataaggag gggatggcat ggagcagaaa attctatgtg aggtcaacaa 2835241 ctgttcttat tggggcaaag gtaacaaatg caccgctgat gccatttatg ttgtcagcca 2835301 tactggtgaa acggctgaaa acagccggga aacagactgc aaaacgttta agccgcatga 2835361 tttataatta aaagaaagag ctgcatcagc cagctctttc tttttgcatg ttgagtgttc 2835421 tcagcttttt agttatgacc ccgtttgcag gtgaaaacaa aaaggcgctt gcataacata 2835481 cacctgtcat ggccgccatc gctcctgaaa tcgaaacatt aagccacgtt gcgaagaaat 2835541 agcccatgac cgccgacagc ccgccaatca acgcgctgag aatcagcata taaagaagcc 2835601 ggtctgtcag caaatgtgcc gcagccggcg gaacaatcag catggccaca accaatacgg 2835661 cacccaccga atcaaaggaa gcaacagtcg tcaaggacag catgcccatt tgcacgtaat 2835721 gaatgagcaa aaccggtatt cccaaggcta aagccatttg aggatcaaac gaagcgattt 2835781 taaactcctt atagcacaca ctgatcaaca ctacgtttaa aaccagaaca gatgccagca 2835841 tccaaaacgc tttcggccca atatcaaccc cgaataccgt caccgtattc cacggcacaa 2835901 aagcgatttc tcccattaac gagtgctcaa tatcgagatg gacattcgct ccatacacag 2835961 aaagcaaaat aaccccgatt gcaaataagg atgtaaacac aactcctatg gcagcatctg 2836021 attgaacccc cttgctatga agaagctgaa ccaagaaagc cgttaacaga ccggttgcgg 2836081 ctgcgccaat aaacatataa atcccatcga gacttcccgt cactagaaaa gcgccgacaa 2836141 tgccaagcaa cactgtgtga ctgattgcgt cggccagcat cgccatgctt ctcagcacaa 2836201 gaaatgtgcc gatcaatccg cagcttacac cgactaatac accggtagct ataatccatg 2836261 cttcaaaact catttgcgat ctgtcccttc tcggcatcat gagacgcttt tcgacgctca 2836321 ggcatccgtc catacagctt taagagtgaa taaagccgct ctctcgtttc tctcggtaaa 2836381 cggtccgggt caaagtagtc ctgatcggat tctatattgg caagttccat ttcatgcatg 2836441 agatacactt catacatccg ctgcttcaaa gctgtgtgat agcctttttc tatccctttg 2836501 cttgtgattt gccaaatccc attttcgata cgctcaatgc acctctcttg ttccaagtca 2836561 tttaatgcct taaggcataa tgaaggggat aggcgtcttt tctttcttac actttcaaca 2836621 gttacacaaa gattattctt ttcatactgt tcataaatcg ccaaaagcac ttgctccctg 2836681 cttgttctgc gccgcagcct catcagcctt atggctttag cagccaatcc ccgcttaggc 2836741 gcgcaaatca ttgaaaaaag aaagagcagc gttgcagata agatcattaa tggccctgtc 2836801 gccattccct tcatcgtggt gctaagcagg gttccggcca ctccgctgac cccgcctgta 2836861 atcccggcaa tgatgatcat cccggttaat cgttcggtcc aatatctcgc ggttatggca 2836921 ggtgtaatca gcatagccgc cattaatatc acaccaacag tctgaagccc aatgacgaca 2836981 gcacagacaa tcagacaagc caaaagcccg tttaaaaaac gcaccgggat tcctaatccc 2837041 tttgcaaacg cgagatcaaa agtaatcaat gtaaattcct taaagaaaac aatacatagg 2837101 agcagtagaa cagcggatat ccctgcaata aggatgatat cctgcctgac caatgaagca 2837161 gcctggccga ataaaaaaga atcaagcccg ctttggcttc ccgccccctg ttgctgaata 2837221 tatgtcagca gaatgatccc gacgccaaaa aacacagaaa gaacaatccc gatcgccgag 2837281 tcctcctttg tttttgaaag ccgaggaatc agctgaatac aaaacgttcc gagcagtccg 2837341 gcgagcgctg cccccagcaa aaagaaaggc agtgattttt gcccggtgaa cagaaaagcg 2837401 agacacactc ccggcagagc tgaatgggcc atcgcatcgc cgattaaact ttgctttctc 2837461 agcagcacaa agctgcccaa aacaccgctt gccgtcccga gcaaaagcgt accggccagc 2837521 acccactgtg tattcggatg ctgaagctgc agccacaaac tttcaaacat tgcgctcact 2837581 ccttatgtcc ttctgccagc actttatctt ttaaaaacgt aagccttcct ccatatgttt 2837641 tttgcaggtt ttcgatcgta aaaacgtttt ccgtcggtcc gaaagcgatt ttccttaaat 2837701 gaagcagtaa gatccaatcg aaataatcct cggcggtctg cagatcatga tggacgacaa 2837761 gcacggtttt tcctttttct ttgagttctg ccaacagcgt cataatcgcg cgctccgtcg 2837821 ctgcatcaac acctgcaaac ggttcatcca taaaataaat gtcagcgttc tggcagagtg 2837881 cccgggcaag aaacacccgc tgctgctgtc cgcctgacag ctggctgatt tgccttttcg 2837941 cataatcatg catcccgact tttgttaatg cggccttcgc catctccaca tccgctttct 2838001 ttggcctctt taataaaccg attctcccgt atcttcccat taggacgaca tcgagcgggc 2838061 ttgtggggaa atcccagtca accgagccgc gctgcggaac atatccgatt ctggtccgct 2838121 gatccttata gtctttgccg taaatagaga tgtctccgga agctctgggc acaagaccga 2838181 gaatcgtttt gatcaaggtt gattttcccg cgccgtttgg gccgataatg ccaataagtt 2838241 ttccttcagg cacctgcagc gaaatgtcct gcagtacagg ctttttatga taagcaaccg 2838301 tcacattatc aagctcaaca gggaacatat cctccacctc ttttctttat ttaagcgctt 2838361 tagtaatcgt gttgatattg tggcggaaca ttccttcgta tgtgccttct tttgtgccct 2838421 tttcacccat ggcatccgaa taaagctgac cgccgattgt gactgtatgg cctttttctt 2838481 tagcgccttc caccactgca ttgattgatt tttcagatac actgctttct acgaacacag 2838541 cttttatttg tttttctgtc agaagatcaa ccagctcctg aacatccctt aatccatagt 2838601 ccgaatctgt gctgagtccc tgcaggcctt ttaccttaaa tccatactca ttcccaaagt 2838661 acgcaaacgc atcatgagca gtcacaagca cacggctttt ctccggaata tgtgcgatct 2838721 ccttacgcga ccacttatct aaatattgca aatcttcttt gtactctttg gcatttttcc 2838781 gaaaggcatc tgcgtgctga ggcattgctt tgctgaattg cgcttcaatt tcatccaccg 2838841 catagatcca taacggaatg ctgaaccaga cgtggggatc aaacgtcttg ccttcccccg 2838901 cgggaataag cttatttttc ggaatggcct cagctactgc cgccgattgt ttttgttcgc 2838961 cgattttttg gaggacatcc tccattttcc cttccaaatg caacccgctg tacagaacaa 2839021 catcggcaga cattaatttt ttcgtgtcac cttgggaagc tttgtaaagg tgcggatcaa 2839081 cccccggtcc cattaaagag gtgactttta cgtgcttacc tccgatgttt tctgctgcat 2839141 cggcaatttg agatgttgtc gctgtcactt gtaattgctg atcagcgctt tttccggctg 2839201 aatccgttcc gcatcccgtt aaagcaaagg tcgcaaaaag tactgctgcc atcagccctt 2839261 gtctcatatt tctcctcctc tttgccatca atgtccgatt gttttatctt atgttgtcag 2839321 ttcttagaca tgtgacatta aattagccaa aagcatgttt tatttacaca ggacaaaaag 2839381 tttccctcat gcaaaattat cgcgtttggc catttttgtc aagctgattt acataaaaaa 2839441 accggctggg tcagcagccg gtccaaacga gaagggatgt attcaacgaa cacttttact 2839501 gtaacagcac agtgtcattt attcaaaata gcaaaatgct tttttcttaa ccatgctgtg 2839561 tgaaaacatc cattttggtc acatattttc gcataatatc ttggtttacc tcaaccccta 2839621 aaccaggctg ttttgacaca gaaataaatc cattatcaat acgaatatca ggagttacaa 2839681 tatcttcatc ccaatagcgt gaggatgaag atatatcgcc aggtattgtg aattgaggca 2839741 gtgaagcaag cgccacgttc tgcgctcttg atatgcctgt ttccagcatt cctccgcacc 2839801 aaacctgcat atgatgctct ttgcataaat catgaatttt taaggcttct gttaagccgc 2839861 cgacacgaga aggttttata ttaataattt tgcagcttcc tagctcaatc gcccgtctcg 2839921 catcatcaac tgaacaaatg ctctcatcaa ggcaaatggc cgttttcaaa tgtttctgca 2839981 agtggcggtg gtcaacgata tcgtcagctt ggagcggctg ctcaatcatc attaaatgat 2840041 agtcatcaag ctcctttaaa cggctgatat ccttcagttc gtaagaggaa ttggcatcgg 2840101 ccataagcgg gatggttggg aatcggctgc ggatggcctt gaccaattcc acatcctgcc 2840161 caggctgaat tttaattttt attctttgat aaccttcttt ttgatagctc tcaatttcct 2840221 tcagcatatc gtcaagaggc gccaggccga ctaccacccc ggcagggact ttatctcttg 2840281 ttccgcccaa tgcctcagca agggatacgc ccttcttttt ggcataaata tcccatacag 2840341 ccgattcaag tcccgctttt gccatccggt ttcctttata ccgcgccagg ctgtccggca 2840401 cttctgaagg gtgattgaat tcacggccga cgacatttgg gataaaaaaa tcttttagca 2840461 tatgcaaaca tgttccaatg gtttcctcgg tgtaccaagg cgaagagaaa gcggaaactt 2840521 ctccccagcc tgtgacacct gatgtatcaa tggcttccac gatcagaaat ttacgctctt 2840581 gaagcgtttc gatactgttt ttaaacggtt tctttaagtt catgctcaaa tggtaaagcg 2840641 tgattttttc tatttcgatc atagcagttc tcctttacgc gcatccttca gctgatttcg 2840701 caagagctta ttagacgcat tgcgcggcag gcggtcaagc acaaagaatt ttgccggaat 2840761 tttatacttc gccaagcgtt ctttgcagta gtcagtcaat tctcctgcgc tcacaggctt 2840821 gtgaaggaca agataggcgt gaggcacttt cccccatttt ttgtcctcag cccctgaaac 2840881 cccggcttcg gccacagcgg ggtgtgaaag cagcactgac tccacttcgg ccggataaat 2840941 gttttctccg ccggatatga tcagatctga acgtctgtct aatacatata aaaagccttc 2841001 attgtccaaa taaccaagat cacctgtttt cagccagcca ttttgaaagg aggcttcgtt 2841061 tgcgctctcc cggttaaaat agcttttcat gacattcggg cctttgacca tgatttcacc 2841121 gtgttcatac ggttcacata cctgtccgtc ccgctctatt ttgatttcac acgaaaacag 2841181 cggtttcccc gcagatccga gcttttccat gctgaattcc ggcgacaggg taacaatttg 2841241 cgagcatgtt tctgtcattc catatgactg aaagacaggg aatcctttct cacggcattc 2841301 ctcaagcaat ggcagcggtg caggaccgcc gccgagaaga atgcatctga tggattcagg 2841361 gcagcggttt gtttcttcca aaagactggc cagcatagtc tgcaccgcag atatcattgt 2841421 cacttcatgc ctgttgatag aatgcagcac atcgcttacg gaaaaacgct ggtgaagcac 2841481 gacagtcatt ccatagatca cagatttaaa taatgcggac aatccgctga tatgaaagag 2841541 cggcaatgcg ataagccagc ggtcttgttc tgttataccc aaattaagag cggacgacac 2841601 cgcactgaaa taatggtttc cgaacgtttg ctgaactccc ttgggctttc ctgtcgtacc 2841661 cgacgtatac atcagcgttg ccgttgcatc catttgcata taagcctcga tctcaatttc 2841721 ctctgctgct tctttcatca gttcatccac atcaatcgtt tgaacgatgt gttcatattc 2841781 tttcttctca aagcttgaat ctgtcaataa aaagccggat cccgaatcct ccagctgaaa 2841841 cagcctttca tgtgttgaca gcttcgtatt caaaagcacc gccttaacac caagcaaaaa 2841901 acaagcgtga acagcgtata ccatttctgc acggttttgg agcaaaatag ctgcagtatc 2841961 ccctttccga accgaatgag cggcaagctg ttccgccatt cgtttagacg cggcaaacaa 2842021 ttctgcaaat gtcacggttt ggtcttcata gatgagagcg attctctcag gtgtcagctg 2842081 tgcccgctgc atgagccagt tgggctgttc tgtcagcatg tcatcatctc cgaggtaaaa 2842141 tgtctgtatt gaaaagaaaa cagcttggac cgcaaagtct caagctgttg gtttactaga 2842201 tattgctgat cacggaaaac gagggaactg tccgaaatca ggtttgcgtt tttccttaaa 2842261 ggaatcacgg ccttcttttg cttcatctgt tgtgtagtaa agaagggtag catcccctgc 2842321 aaactgctga attccagcaa gtccgtctgt gtccgcgtta aacgcagctt taagaaagcg 2842381 cagtgcggtc gggctttttt caagcatttc ttcacaccat ttaatcgttt cttcttcaag 2842441 ctgttccaaa ggaacgactg tgttgacaag acccatgtcc agtgcttcct gtgcgttgta 2842501 ctgacggcat aggtaccaga tttcacgtgc ttttttatgt cctacaattc gagccaggta 2842561 gccagaaccg taacctgcat cgaagcttcc cactttaggg cctgtttgtc caaaaattgc 2842621 gttgtccgca gcaattgtca agtcacatac gatgtgaagc acatggcctc cgccgatcgc 2842681 atatccggac accatcgcaa caaccggttt cgggatgacg cggattaaac gctgaagatc 2842741 caatacgtta agacgaggga tctggtcgtc tcctacatat ccaccgtggc cgcgcacttt 2842801 ttggtctccg ccagaacaaa atgctttgtc ccctgcaccg gcaagcacga taaccccaac 2842861 gttttggtcg tctcttgcgt cagcaaacgc atcaatcatt tcagcaaccg ttttaggggt 2842921 aaacgcatta tgtacctcag gtcggttgat tgttattttt gcaatgccat tatacgtttc 2842981 atacaatatc tcatcgtatg tccgttttgt tttccattca gccatatgat gacctccttt 2843041 tattctctat gtgaatgagt cagatgcttg tcaaaaactc actcactatt ttaccaaaca 2843101 atcgcggctg ctccacatgg accgtatgtc ctgcttttgg aacaatctct attctactag 2843161 aaggaagcat cttatgcacc tcttgattga tggcgcaaaa tttttcgtcc cactccccgc 2843221 agatcagaag cacaggaaca tctatttcct ctacacggct ccacaaggaa ggctgtgaac 2843281 cggtgcccat gccggttaaa ctgttcgcaa gcccaatctt attgttccgc agacggcccg 2843341 atcgtatcct gtaccgaata tcttcagcca gcctctgctg agatgaaaac aaagggatat 2843401 tctcccaata cgcaacaaac gcttcgagcc cgtctcgtaa aataaaatca gcaagcttcc 2843461 ggtcccgcat gattcgttcc cgccgttccc caagtgtttt gagccccggc gtcgtgcttt 2843521 caagcacaag tgccgatacc cgctcgggat atgtcatcgc aaaagagtaa gcaagccttc 2843581 ctcccataga atacccaatc aatttcactt tgtgaagttt taattgatca aaaatctcgg 2843641 caaggtcaga aacttgccgg gttgtgctgt atcttttccc attcagcggg gcatcggttt 2843701 ccccatgccc taaacaatca attttgatca aacgggaatc aggcagcatt tcatcaagaa 2843761 aagtccatga ttgtttgctg ccggtaaacc catgcagaca gacgacggct tcggaagcat 2843821 tcggtccctc gtctgccact gcatatcgga caccatctga taccgttatg tttacagttc 2843881 ccattgtttt ttcacttccc gcacagcctc attcagcata tcgcgatgaa gctggactct 2843941 tgattggcga tccgttttga tttcaatcaa atggagtccg ggcttgtctg cctgcggcgc 2844001 gtaagctgtt ttgaattcat cccaagaagc cgggcatgaa tacgttccgc cgtaaagtgc 2844061 agccgcatgc ttgaaatcga gccctgtcgg tgtgccgaac aaatcttcaa agtgtgtctt 2844121 ctcagaagcc tgcggcaaaa aggagaaaat ccctcctccg tcattattga caagaatcac 2844181 agtaagagga atacccagct ttttggccgc cagcaggccg tttaaatcat gataaaaaga 2844241 taaatctcca atcacaaggg taacaggcgc ttttgttcct tcacataccc ccatggcaga 2844301 ggagacgaca ccgtctatcc cgtttgctcc ccggtttgaa taaatccgga aagggcggtc 2844361 ctgcttttca aaaaacgtat caacatccct gatcggcatg ctgtttccca caaacagcga 2844421 gctgttttca ggcacaagat gctgaaggat tcgatagaga ttgccttcaa acgaaacatc 2844481 ttcactgctg attgtttgca gatgctcgcg gaaccgccca ttgacaaact gccacttttc 2844541 cagccactct gaggatctgg tggcagcagt aaggcctgcc atgatctcct cagcaaaaac 2844601 agacgcatta caatgaatca tatgcgcgct tgcctgtgtc gggtctctcc accctccatc 2844661 ctcgtcaatc acgatttgct gaatcgtcgg atcatcctta agccataaga aaaccggttt 2844721 tgaaacaggc atcggtccaa accgaatgac aacatcagga cggagtttcc gcttcagctc 2844781 atcatctttt aaaaacgaat catacgcatc aataacagtg cttttatcat gaacaccatt 2844841 ccgcagatta gacagcggat ctgctaaaat tggatactga agcgcttttg acagcgcaat 2844901 aatgttttcc ttgtccgcat cactatggag ctctccgcag acgatcattc ctttttcagc 2844961 ctctgcgagc atctcagcca catcagacag ggactctcgg tcaacagact gcgtacccgt 2845021 tttcacagac acatgacggc ctgttctcat tcttccaaac ggctcatctg aaagatccgg 2845081 catcagcggt tcgcgcagcg gcacattcac atggacaggc cccatcgggc gcttttgtgc 2845141 ttctccggca gcgcggcttg ccagcgttcg gatgtatctc agcatttgcg gagactcttc 2845201 aggaagagca gagtctgtga aaaacttaac aaagttaccg aataagaagt gctgattaat 2845261 agcctgcggt gcgcctactt cgcgcagctc atgaggccga tcagcagtta acacaataat 2845321 aggcaccctt gaataatggg cttcaaccac agccggataa aagttggccg cggctgttcc 2845381 agatgtacag atcaatagta cgggacgctg cttcgctttt gccaaaccta atgcaaaaaa 2845441 tccggcagac ctttcatcaa tttggacatg gacgctgata tcgggatgcg cagcacaaag 2845501 aacagccagc ggtgtagatc ttgagcccgg acaaacgacg gcgtccgtaa ttccggaaag 2845561 ggcgaattca tcaataaaac ttccgatgta atgagtaatc gggttgactg tcaacgcctc 2845621 tcacctccta atgcagagat catcggcttc aatttaatct gtgtttcttc atattccgag 2845681 attggttccg agtcttccac aataccgcac ccggcaaaca gccttgctgt gcttccttcg 2845741 atgagccctg aacgaatggc gaccgcgaat tccccgttat cctggctgtc aatccagccg 2845801 ataggggccg cataccagcc gcgggacatc ggttcaatct ccctgatcac gtcaacagct 2845861 ttttcctgag gtgatccccc aagcgcggga gtggggtgca gcttctcaat taagtcaaaa 2845921 atcgaagcag actcgcgcag ctgtccgaca atcggcgtaa acaggtgctg aacgcttttt 2845981 gttttgtaca aaacaggtcc atcaggcttt tcaacctctg aacagcttga tacaaaagca 2846041 ttatgaatca tacctaccac aatatcatgc tcaagcaggt ttttctcatc gtttaataat 2846101 tcaaggccta tccggcggtc gtcttcttca ttcacgcctc gtttaatgga gcctgccaga 2846161 caggaagaca tgacagtgcc gccgtctctt ttgatcagtc tttccggaga cgcgccgaca 2846221 aaggttttgc cttcttgttc aattgcaaaa acatagcttg tctgctgatc gtccagaagc 2846281 gttttaagca ccggttcaat ttggattgga ccgtcaaacg tgagcagcag ctctcgggca 2846341 agaacaacct tatcatattg tttctcttta atttggcttg tggccgtttc gattgctttc 2846401 agccaatcat ccttatccag ctcttcggct gctgcaatca cagcctgatc ttcttgcttg 2846461 aaatcgggaa ccataaattc cgccgcaaaa gcttttaagc cttctaaaac agcttctgcg 2846521 tcttctcctc cgcttaccca tctgttaact gttaagaacg ggccttcagc agtcatcgtc 2846581 agcataagcg caggcacaaa gaaatcccct tccgagaaat ggtcccattg tgaacctctt 2846641 tcttcgcaag ggtcaaaaga aaatcctccg aataacacag gtcccactgc agaatgctgc 2846701 agcttttctt cttcataaat atgaaaagcc gtctttttaa agcgctccca ttgttcaaaa 2846761 acctcacgat accgctcgct gtttttttga tttgtctgga aaaccgcttc tttgccaaga 2846821 ccgactattg tcaattcact ttcaggatct gaccaaaaaa atcgattgcc tgtatatttt 2846881 tttgctccgt aattgaaaaa tgatagaggg tcaagagact cgatttgtct cgaatagctt 2846941 attaagacag catggttgac ttctttggct ttatgtaatg catgtagaac ttcctttcgg 2847001 aacgtacgct gcaccgttgt caccatgaga cattcctcca taatccttaa aatgctttta 2847061 ataccataca cctgtgtctc ctttgtgtca aacacagatc atgcagtcca aatggcctgc 2847121 cttacctatt ataaacctaa tttcagaaat gaaaaagaaa caaagcttaa atttctttct 2847181 ccactgatag caaaggttgt atccgcttac cataaaagga aaacctccta tattcctcca 2847241 cccgccattt atgaaagttc tcaggcgatc tgttcatact aaaggtatgc atcacagaga 2847301 aacgaggcga tcacattgct tacgaaagaa cagcttcagc atttaaaaaa tgaactggaa 2847361 caaacgaaaa aagatatctt aaaccgtttc aaagacaatg atcattttca gcttaactca 2847421 gcctttcctt atgattcgtg gggtgagctt tcggcatacg acaaccatcc cggcgatcag 2847481 gcgacagaac tttacgagcg tgagaaagac atcgctctag acttgcatga gagagagcac 2847541 cttcgggaca ttgagcattc attgaaggcg atagaaaacg gtacgtatgg catttgtgaa 2847601 gtcagcggaa aggaaatccc tttcgaacga cttgaagcgc ttccgactgc cacaaccctc 2847661 gcggagtatt cgtcacagga cgtggtttcc aaagaccgtc cgattgaaga agaaacacca 2847721 ttcgggcaat ttgaatttga tgatgatgaa gaaatcagag cgccatatga cagtgaggat 2847781 tcctatcagg atgtcgaaaa atatgggaac tcacaaacgc cgcaggatat ggaaaaccct 2847841 ccgctcagct atgatgatat gacgatgaat gccgaagaga atatcggcaa tacggagtct 2847901 tacgaaaatt tcatcgctac agatatcact gggaaagaaa ttaccgttta tcaaagcaga 2847961 gcccatgagc gctatgaaga agaacttgac gaagagggaa tcatgaccac attcggcgat 2848021 ctccacgctg attgaacccc caattattgg gggttctttt ccgttttcag catatcgtaa 2848081 atcagcttca gataatcctt ttgcaggccg atgtcatacc gctcgccctc tagcaatttc 2848141 ccgtatacgg tacatgcccc gagcgaagct tttatcgcat ccgttacctg cacttctcct 2848201 ccgctatcag cttctaatgc ctccagctca ttaaaaatat ccggtgtgaa aatataacgc 2848261 cctgctgcgg caaaatgaga cggagggttt tgtttaggct tttccacaat atcctgtatg 2848321 cgataaagcc ctttttcaac aggctcccct tttatcaccc cgtaatgatg taaatcctcc 2848381 gtttttgttt cttttaagcc gatcacactg gactgatatt tcgtatacgc ttcaatcagc 2848441 tgccccaaag ccggctgatt ggcggaaaaa atcagatcat ctggcaaaac gacggcaaaa 2848501 ggctctcctc ctgcaaattg ctttccgaaa gaaatggcgt cgccaagacc ctttgcataa 2848561 ggctgccgca catagtgaat ccgtatatcc ggaatgggat gctctctaag taaatgcagt 2848621 ttattcttag aggccaaaaa agcctcaagt gccaaagagg aatcaaaata gtcgacaatc 2848681 agatttttat ggctcgatac aaccatcaaa atgtcctcaa tgcctgactc ctttaattct 2848741 tcaacaagat aatgaatcac aggcttagat cctaccggaa acatttcttt cggaatcacc 2848801 ttcgtcaccg gcagatttct cgtgccgaat ccgcctgcag gaatgatcgc tttttttatc 2848861 atggtatttt cccctcagct catgtttatt acatgatatt ccaagagcgc atcccgatgt 2848921 ttgtacatct gaaattaggc ggaagcaact gggcagaaag cggaatcacg aaccagccct 2848981 tttttaatag gatattgata tatgaccagt aatcttgtaa aggagctcag gtgatgaaaa 2849041 tttgtgtggt tggcgccggg tatgtcggtt taaccctatc agcggcactg gcatccatcg 2849101 gacatgacat gatatgcaca gacaaagacg tcaaaaaaat cgggcagctg aaaaaaggag 2849161 tcattccctt ttacgagcct gggctttcag atgcaatact tcgttgcggc aatctctcgt 2849221 tttcttctga agtgaaatcg agcatggagg aatgtcccgt tatttttatc gcagtcggaa 2849281 ctccgccgcg ttcggacgga tcagctgata cgaaagccct gcagtccgtc atcggtgatt 2849341 taagcgaggc gatccgatcg tataaaacca ttattacgaa aagcactgtt ccgcccggga 2849401 caaatgaaaa catagcaaaa cagctgattg cctccggagt gtctaaaaac ctctttaata 2849461 tcgtatccaa tccggagttt ctgcgggaag gcaatgcctt atatgacatg ctgcatcctg 2849521 acaaaacagt catcggtgtt caggaagaag atcacgtatc ggcagccatc gtcaaatcca 2849581 tttacaaaca cattgatacc ccttttatcg ttacaagctt agcgggagca gagctgatca 2849641 aatatgccaa caatttcttt ttagcggcca aaatttcgtt cattaacgaa atggcccgca 2849701 tatgtgaagc ctatcaatca gatatctcag atatttcccg cgctatcggt ctagacccaa 2849761 ggatcgggaa gcactttttg caggcaggca tcggatacgg aggctcttgt tttccaaagg 2849821 atctgcaggc gctgcaattt gctgcccagg aaaaaaacac ggagaccttc ctgctccggg 2849881 ccgtgcagca cattaatgac acccagcttg gcctgtatat caaaaaaata cagtcattct 2849941 tcgaaacact tcaaggcaag aaagcggctg tactcggcat ttccttcaaa ccgaatactg 2850001 atgacatccg gaattctcag gctgtcagac tgatggaaag gctggcggag ctgggatgtg 2850061 atgttcatgc atatgatcct gaagctgtac ttccagaaca tttgcggcaa catgtaactc 2850121 agcattctca agcttttgat gcgatcgaag agagtgactt tttatttttg gcgacagaat 2850181 ggtctgagtt tttagcgttt gattggaaaa aggctgcaga tatcatgaaa gggcgtcttg 2850241 tgattgacgg acgcaacgta ctaaaaaaag aactgatcga ggcttgcggc ctgatctgta 2850301 cgggagttgg ccgtccatga aaatactcgt cacaggagca gcgggcttta tcggctccca 2850361 cctctgcgaa gaattactaa aagataagaa acataacgtt atcggaatcg atgactttat 2850421 cggtcctact ccattttcct tgaaattaaa aaaccttaaa aacctgctgc cggaaaagcg 2850481 atttacgttc ataaaggaaa atctgctgac agccgatctt gcttccttac tggaaggagt 2850541 ggacgtcatc tttcatttgg cggccatacc gggtgtccgc tcaagctggg gcaatcattt 2850601 tcacccatat gccgcacata atatccaagc gctccaaagg ctcctcgagg cgtgccggga 2850661 acattctatt caaacgttcg tctttgcatc cacctcttcc gtctatggcg aaaaacaagg 2850721 aaaagtcagc gaaaacacgt cgctttctcc tttatctccg tacggggtaa caaagcttac 2850781 gggagaaaag ctttgccatg tgtataaaca gagctttggc attccaattg tgattctccg 2850841 tttttttacc gtatacgggc caagacagcg gccggatatg gcttttcacc ggctcattaa 2850901 gcagcacctt cagcaaaagc cgcttaccat cttcggtgat gggcagcagt caagagattt 2850961 cacttatatc agcgactgtg tcaaaggcat caccgctgtt cttgggaaac cccaccttat 2851021 tggtgaaaca gtaaatatcg gcggcgcaga gcgtgcctca gtcttaaaag ttgtctccct 2851081 cattgaggat atttccggga gaaaagcaac actgcacttt tcggacaaaa tagcagggga 2851141 accgagcaac acgtgggcgg atatttcaaa agcaaaacag ctcttgcatt atgatcccgc 2851201 cacatcctta aaggatggct tgaccaacga aatcgcctat ttatcgtcgc tgtatcaggg 2851261 ggaataaaaa tgaagcttgc ctttatctgt acagaaaagc tgccggcgcc cgcagtacgc 2851321 ggcggcgcta ttcaaatgat gattgacggt gtcacgccct atttcagcag caggtacgac 2851381 ctgaccattt tttcaataga agatccatcg ctcccaaaaa gagaaacaaa agacggcgta 2851441 cattatatcc atctgccaaa agaacattac cgcgaggcgg tagccgaaga gctgcgagcc 2851501 tcttcctttg acctcattca tgtgttcaac aggcctttaa atgtctcttt atataaaaaa 2851561 gcctcaccaa acagcaagat cgttctgagc ctgcataacg aaatgttttc tgaaaaaaag 2851621 atgaccttcg cgcaaggaaa agaagtactc gacaatgtct ccatgatcac aacagtgagc 2851681 gaatttatta aacaaaccgt cattgaacgt ttccctgaag ccgaggacat cacaaaagtt 2851741 gtgtattccg gcgttgattt aaactcttat ccgcccgtct ggacgatgaa aggctcggct 2851801 gtcagaaaaa cataccggaa aaaatacggt attgaagata aaaaagttat tttattcgcc 2851861 ggccgcttaa gcccgacaaa agggcctcac cttctcattc acagcatgag acggattttg 2851921 cagcagcacc ctgatgctgt actggtcata gcaggcggga agtggttcag cgatgacagc 2851981 gaaaaccaat atgtcaccta tctgcgcacg ctggcgctgc catacagaga ccacataatc 2852041 tttacaaaat tcattcccgc agacgatatc ccaaaccttt ttctgatggc agatgtattt 2852101 gtgtgcagct ctcagtggaa cgaacccctc gcccgtgtga attatgaagc aatggcggcc 2852161 ggcacgccct taattaccac aaaccggggc ggaaacggtg aagtcgtaaa acacgaagtc 2852221 accggccttg tcatcgatag ctacaacaaa ccttcttcat ttgcaaaagc aattgacaga 2852281 gcctttacag atcaagaatt aatgaacaaa atgacaaaaa acgcccgaaa gcatgtagaa 2852341 gctttattta cctttaccca tgctgccaaa aggctcaata ctgtttacca atccgttctg 2852401 accccgaaaa acaaacaatt tccgccgcct tttctgacgc aaaattttga tttatcatct 2852461 atcaatcagc tttttgtgaa agcaaaaaca taaaacctac agctcgtgtt gcaaaacggg 2852521 ctgttttttc gctacagaga acttaaaaaa aggcataaat gtgactttat gccttgcgct 2852581 ttacagtttg agaaaaccat ggagctggtt tagattcact tggaagaatg atgatttcca 2852641 ctttagcttc ttccgctaag tctggttctt catcttcatc ctcttcttca tatgggggcg 2852701 ctgagcgttt cgaatcacgc tcctcctcag gctccagagt ggtttcgaat tttgtttctt 2852761 cttcatcatc gacgattttg cgatctgttt ccttttcctt cgtttctttt tgatattctt 2852821 tcggtgcatt gatgtgaggg agctctcgaa tgctgcccac atctaaatgc ttctcctctt 2852881 cttccttctc agctgagatt gagtcatgag cctgccatcc catcggtcca ggcggtgtaa 2852941 atacgaattg gtcgagatcc agtttagaaa tagaggcttt ttgtctcgat gacctcatgt 2853001 caattcgcct cccgatacgc ttttatcttt ttatacagtt ccggcagttt atccaaaaac 2853061 gaatctttag attcttcaac agaaatcatg ttttgcagcg cccagttata cttctcatct 2853121 gaccacgttt tcttttgctt caaataatat ttgtgcccga ttgcacagaa caaatgcgga 2853181 aacgcgagat caatccaaag tacctcgtac tgtttttctg tgagcggata cactgcgtcg 2853241 taggccgcaa gcagtgcaac catgaaatca gtatcccata cagaaagctt aaccatcact 2853301 ttattcagca gaatacgaag gtctcttgac ggcaaatcgt aggtaatcga gtgaagctcc 2853361 tttaaaaaag gctccccttc gatctcagtc aaacgtgcca atgtaaaatc ctgaaaacag 2853421 aatccgccat gctcgagtgt ctcttttgtc caggtttcgt attctgagtc atcaagcgct 2853481 ctgagagctt cttttcctct tgccagcatt ttatcagcat gttttaagaa agtttgcgaa 2853541 aatacgtcat caggatagga tgctgcgatc tgcatattcc cttcaagttc ctgcagcttc 2853601 caacggtaca atttgtgcca ttttcccagc ctgcttctct tcttgctttc atctgtgcaa 2853661 acatatcctt ttgaggcatg atgaaaatgg ccggcaaatg acatgacttt tttcatttgc 2853721 tctgcatcat agtaaatcat ttcttttcct gtcactttgt catataaact gtaagaaacc 2853781 tgatccgtgc ccaagcagct accgccattt tttgtttgat gaatcggcgc tatcggcagc 2853841 cctttctctt gtaaatgggc gtgtgcctga gtgataaaaa gcatccgctc cggtttcatt 2853901 tgcgcttctt ttagcagctt tgggccatga tcagtttcga cttcccagat tttgcgcccg 2853961 cttttgttcg atttcagcgc cacatggtcg atatgaaacg gataataact gagaatttcg 2854021 gacacaatct gttcttcatg ctctttttgg tacactctgt tcaccccttc tatctgttct 2854081 tttcatagac gctgagcaga ttttcagcca ccctctgcca gccaaaattg ctttctgcct 2854141 cacggcggct gtatttccca agccgttccc gcttttccga gctgctcagc aaatcattga 2854201 tacgttcggc atattgttta ggattttcaa agtcatgaat gatgtagccg tttttccctt 2854261 cctctatgac ctctggattg cctccccgat tgcttgtaat aataggaagt cccgcagcca 2854321 tcgcttcata atgcaccctt gctaaaggct cctgccattg cgaagagcat acaaatacat 2854381 ctgacatggt ataaaggcgc ggaatgtcct ttggcttcac aaattgaata aatgtgacat 2854441 gatccttttg catcgcacca agggtatgaa gatgtttgac atagttattt aattcattat 2854501 ctccgaacca ttttgacccg ataaacacca tcatgacatc ggggtgctcc tcaatgatgt 2854561 ccggcaaagc ctgcaataat atgtgcgggc ctttgacttt gctaagccgg ccgacaaaca 2854621 agacgatttt tttgccgtga agccccagct cgcttcgcat ctcttcgcga gctcgctgcc 2854681 cttcattcgt ccagcgaggg tggtacgttt ttaaatccac accagaatac accgtttttg 2854741 tttttgatcg tgctgacgga aaacggcttg tgatcgtctg tccgatataa tcgctgaccg 2854801 taacaatctg cgctacggag tcgatgcaaa tctcgccttc cgcctggctg attttatcgt 2854861 aagcgaacat ttcattgtga acgcttaaaa taaaaacagc atccggcgcc tgtttcttca 2854921 atttcggaac ccagcttggg cgattacaaa catgcacaag atcaaaacgg ctctttttca 2854981 gctctgctcc aacggcttct tcataacggt cttcatccaa atgcacataa tggacaccgt 2855041 ctaccttctc tctatcagcg agattcggat ctttaataga aaacacagtc acctcatgtt 2855101 tttttgcaat taaaggggca accgcttcga ggtagatttg aatggcgcct cctcgaaccg 2855161 atgggacagg aagcttctct gtggcgatca gtgctatttt catacatagc ctccattcct 2855221 gcatgatttt taactagtta gaatcatgat acggctgaac aaccaacttg tgcggaatgg 2855281 gactgcccta aaaacaaaac gggtaaacaa ccagattcat ctattaaata tagtcaaata 2855341 actcaatcat tttttccttt tgattcataa ggtaggagta aaacaggtaa ggatgtgtcc 2855401 tttaatggca gaaaaccatg aagtcattga ggaggggaat tcatcagagc ttcctttatc 2855461 agcagaagat gcaaaaaaat taacggagct ggctgaaaat gtgcttcaag gatgggatgt 2855521 gcaggctgaa aaaatagacg tcattcaggg aaaccagatg gcgcttgtct ggaaggtcca 2855581 cacagactcc ggcgcggttt gtctaaaacg aatacacagg ccagaaaaga aagcgttgtt 2855641 ttccattttc gcgcaggact atttagcaaa aaaaggcatg aatgttcctg gcatactccc 2855701 aaacaaaaaa ggcagcctat attctaagca cggctcattt ctatttgtcg tatatgactg 2855761 gatcgaagga agaccgtttg agctgactgt aaagcaggac ttggagttta tcatgaaagg 2855821 ccttgctgat tttcatacag cttccgtcgg atatcagccg ccaaatggcg ttcccatatt 2855881 taccaaatta ggtcgctggc cgaatcacta cacgaaacga tgcaaacaga tggaaacgtg 2855941 gaagctgatg gcggaggcgg aaaaagaaga tcctttctca cagctttatc ttcaggagat 2856001 agatggcttt attgaagacg ggctgcgcat caaagaccgg cttttgcaat cgacctatgt 2856061 tccatggact gaacagctga aaaaaagccc taacctttgc caccaggatt acggaaccgg 2856121 gaatacactc ttaggagaaa atgaacagat ttgggtcatc gacttagata ccgtatcatt 2856181 tgatctgcct attcgcgatt tgcgcaaaat gattattccg cttttggata cgacgggtgt 2856241 ttgggatgac gaaacattta atgtcatgct gaacgcatac gaatccagag ccccattaac 2856301 tgaagaacaa aaacaagtca tgtttattga tatgctgttt ccttacgagc tttacgatgt 2856361 cattcgcgaa aaatacgtcc gcaagtctgc tttaccgaag gaagaattag aatcagcttt 2856421 tgaatatgaa cgcattaaag caaacgcatt gcggcagctt atttaagacc atcatttccc 2856481 ccgcatatcg ggggtttgat atttataaga taaagggtaa ttaaatacat gcggaggttg 2856541 caaatatgaa aaagattgtc ggcgctttag ccgtttttgt gattacatat gcgctgtttt 2856601 cagccgcagg ctacctgttt cctgtggacc aagaatggta caattcattg aaaaaaccgg 2856661 actggacgcc aagcggaact gcgatcggca tcatttgggc catcctgttt gccctgatct 2856721 ccctttcagc agccattgta tatgctgcgt tttcatttaa aggtgcgaaa agcttttggt 2856781 ttacactttt gataaattac gtgctcaatc aagccttcag ctatttccag tttacgcaaa 2856841 aaaatctgct ggctgcatcg cttgactgcc tgcttgtcgc catcacagca atcgtattac 2856901 tgatcattgc caaaaaatac agcagagccg caagctatct tcttttgcct tattttttat 2856961 ggagtgcatt tgcgacgttc ttatccttta caatcaattc aatgaatctg tgaacaaaaa 2857021 aagccgctta tacagcggct ttttcacatc atcggcttga tgccccaaat gtccttcgca 2857081 tattcccgga tcgtgcggtc gctggagaaa tatccagaat gagcaatgtt tacaatcgaa 2857141 tgctcagacc atttccttcg ctctcgataa tcagcttgaa ttcgctcctg tgcatctgca 2857201 tatgagctga aatccttcag cacaaaatac tcatcattat gcggaagcag cgagtcaaag 2857261 atcgattcaa attcatctgc ctctccttca aaaaaaccat tgatcaactg atccgctacc 2857321 tgcctgattc tcctgtcatg ctgataatat tccctcgacc tatagccgcc gttttcctga 2857381 tacgatagaa cctcatccgc ctttaagccg aacgtgtaaa tacagtcagg gcccacccgc 2857441 tcaaggatct cgatatttgc gccgtcatgc gtgccgatcg tcaaagcccc gttcatcata 2857501 aacttcatat tccctgtacc agacgcttcc ttgcttgcgg ttgaaatttg ctcacttacg 2857561 tctgatgccg gaaaaattcg ctcagccata gaaactctat aattttctaa aaaaacaact 2857621 ttgatcagct gtttgaccgc cggatcataa ttgacttttt ctgcgacaga atggatcagc 2857681 ttaatgattt tcttggcata ataatagctt ggtgaagcct ttgccccgaa aataaaggtt 2857741 tgcgggtaga ttgaaaaccc cgaatcctcc ttgaggcggt tatacaaata cataatgtga 2857801 agaacattca gcagctgccg tttatatgca tgaagccgtt tcacctgtac gtcgaatatg 2857861 ctctcagggt tcacaaccac cccggccgtg caaaaaatca aatcggcaag ctcttgtttt 2857921 ttcttgcttt tgttgttttg aaactgttca ataaatgcag gatcagtggc gtacggttct 2857981 aaacggatca gtgattccgg ctgcttgacc cattcatcgc cgatcgcctc tgtaatgatg 2858041 gcagacaagc ctggattcgc ttttaacagc cagcgcctgt gggcaattcc attcgtctta 2858101 ttgttaaaac gattcggaaa cagcaagtga aagtcgcgca tctccctttc ctttaatata 2858161 tcggaatgta tttttgcaac gccatttaca ctgtagctgc ctactatggc cagatgagcc 2858221 attttgacaa caccatgcgc tgtaatcgcc atgttctcta tccttttcca gtctccagga 2858281 tacttttccc aaactgcacg gcaaaacctc tcattgatct cttcaataat catgtacatt 2858341 cgcgggagca gcggcttaaa caaatgaatc ggccatttct cgagcgcttc tgacaatgtt 2858401 gtatgatttg tataagaaat cgtatgtaca gtgatatgcc aagcttcttc ccagctcatg 2858461 ttctcttcat cgagcaaaat ccgcattagc tcaggcaccg caagcgcagg gtgagtgtca 2858521 ttaatatgaa tgctcacttt tttatgcagg ccggataaag atttatgtgt tttacggtaa 2858581 ttgttcacaa tgctttttaa gcttgcgcat actaaaaaat actgctgctt cagccgtaaa 2858641 attttcccct catcatgggt gtcatcggga tataagaatt cagaaaccgc ttctgtttct 2858701 cgcttataag acaaaatatt accgccgtga taatgggcat agggctcggc gttccaaagc 2858761 cttaacgtgt tgacagtgcc cgtttcatag ccgatgatcg ggatatcata aggaacagcg 2858821 gtaacaattg tcgcttgttc atggcgaaaa tgcaggcgcc cgcttttttc tgtcatatgg 2858881 acttcgcccc aaaacggcac gtccactgct tgatccgcat tccttacttc ccatacgttc 2858941 ccgtttttca gccattgctc aggcagctcc acctgatgtc cgtctacaat tttttgctca 2859001 aacaaaccat gcttataacg tatgcccatg ccgtgcccag gcaggttcaa cgaagcaagc 2859061 gaatctaaaa agcaagcggc caagcgccca agtccgccat tgccgagacc tgcatcgttc 2859121 tctatctgaa ggatctcctc taaattgatg ccgatttcct ttaaaccagc ttctacaaca 2859181 tcacgaacac caagattcat taagttttgc tcaaggagct gaccgagcag aaattcgatt 2859241 gataaataat atgtctgctt cccggaattt gatctgcttt tttcattcgt ttcgatccaa 2859301 tcagcgctga tatactctct gaccatattg cccaacgttt tatattgatc cagcttggca 2859361 gaatctttaa agctttttcc gcacgtcatt tccagacgct ttaaaaataa gtctgcaaag 2859421 cgttctttac tcgagaacat cccgtccact ccttgtcacc tgctcgaaaa tacgctgata 2859481 ctctttagcc gacttccccc agctgtaatc tgcattcata gcggtcttca cgatgctctt 2859541 ccatacatcc tgttggcaat aaaacgacag cgccctttct atcgtaaatt tcagatcatg 2859601 cgcattaaag gcggaaaacg taaagccatt gcccgttccc tcttcctcct gataggcacg 2859661 gacagtgtcg taaagaccgc ccgtttccct gacaatcgga atggcgccat attgaagagc 2859721 aatgagctgc cccaaaccgc acggctcaaa tttcgacggc atcaaaaaca tatcagagcc 2859781 cgcataaatt tgatgggcta gcggctcatc aaacccgata taagcccggc acttctcatg 2859841 aaaagcaaat tctgcatacc ggaaataatc ttcaaattca cgttctcctg tgcctagcac 2859901 aaccagctgt atgtcttgct cctcaagaag ttcgtgcata attctgcgga caagatcaag 2859961 ccccttttgt ttagtgagcc ttgtcaccat actgatcagc ggaatatcgt ttttctctgg 2860021 aagccccatc cgctgctgaa gcttcgtttt gttttccagc ttgcatgcaa gatcccctga 2860081 atcgtattgc gcctctatat aagggtcgct tttcggctga tagaacgtat catcaatgcc 2860141 atttaatatg ccggttacat catcttccct atattgcaaa acctgttcca actgctcacc 2860201 ataatacggc gtcatgattt catttctgta agtggggctc acagttgtca catgatcagc 2860261 cgcaatgatg cccgctttca taaaattaac aaatccgttg cattctaacc tttcataatg 2860321 aaaatgatcc atctcaagac ccagcaagtc atgtgtgaca tcaggaggga atatgccttg 2860381 aaactgcagg ttgtggatcg tgagcacgct tttcatccgt tcataaaaag gatgttttct 2860441 gtactcctct ttcagcaaat aattgaccat cgctgtatgc caatcgtgag tatgaacaat 2860501 atcggcttga acattcacaa ctttggcagc ctccagcaca gctcttgaaa aaaaggcaaa 2860561 ccgctcaccg tcatcataat gcccgtacaa cgaatccctg ttgaaatagt actcattgtc 2860621 gatgaagtaa taattcacat cattctctgc catatgttca attccgcaat attgctgccg 2860681 ccagccgaca gctacggtac actcagcctg ttttttcata cgctttttcc acggttcagg 2860741 tatttggctg tacttcggca gcatcacagc tacctcattg cctaatcgcg caagcgcctt 2860801 tggcagagca cctgctacat cggcaagacc tcctgatttc acaaatgggg tgcattctga 2860861 cacagcaaat aatatcttca agaattcatc agctctcctt gcaccaaacc ttttcttaat 2860921 acaagcggct gctcagctgt tcctgcagct tccgtcgcct tgccgatttt aacatcctta 2860981 tccgaaatga cctgctcaag aagacaatcc tctccaatct gcgttttttg cataataatg 2861041 cagtttttca gcttcgtacc ctttccgaca tggaccgccc tgaacaaaat gcagttttca 2861101 acctctcctt caagcacaca gccgtttgcc accaaagaat ttttgacagt gctgtgcttt 2861161 ccgtatttcg taggcggctc atccttcact tttgtataga tcggctgctg cggcaaaaac 2861221 acctgctgcc aaaaacgagg ctgaatgagc tccatactgt gggtataata tttttccacc 2861281 gaatcaatga cagcggcata acctgaatat tcataagggc aaatggtcag ggcggaagat 2861341 tccttttcaa cagcctcctg aatggtttta tagccttttt cgctatgtcc gtagatcaga 2861401 tcctttaaaa gcgttgttga catgatatag atttgcagcg actggccgtc ctgaaatacc 2861461 tcggtgacgt cgcagccaac ctcctgatgg cgtttcagca catattgaaa ttgaatgttg 2861521 catacggtat ggctgttgga gattacagca tattgctgag tgcttctgtg gaagtaatct 2861581 agatggtccg aaaactggcg aaaggaaccg aattcatcgt attcgtgatg aagatgggga 2861641 gacgggaaaa aaaagaggcc gtcctttttc cggtgcaaat cccattcctt acccgcccca 2861701 aggtgatcca tgagcgaacg gtaacgatac ttcggaaaaa ttgcaacact cctaatatcc 2861761 gcattcacca tgttggaaag cataaaatca atcagtcggt acctgccggc aaaagggatc 2861821 gccccgagcg accgctgtgc tgttaaatcc tgaagagaat gcttatatgt ggtttcatct 2861881 ataacaccta acatttgatt attgaacact gactctgccc cctcttcagt aattaaatca 2861941 attctttttc tacaaattcc tctgaaacga gcagcacctc ttcaatgtct ttttcggagc 2862001 gaatcactgc gccatccggc agcaccatcc cattaggaac gatggcattt tcaatgacta 2862061 catgctcccc aatcgtcaca tccggcatta tgacggatga tgtaacagtc gtatgcttac 2862121 caacagtcac accttgaaaa agaacggagt gagacacatt tccatataca acacaacctt 2862181 cgttcacaag cgaatcttga acctgcgcat cagatgaaat aaattgcgga ggctgatttg 2862241 gattgacgga gtaaattttc catttgcgtt caaacagctt cagctccgag tcctctttta 2862301 acaaatccat attggcttcc cacaagctct gcaccgttcc gacatccttc caatatccct 2862361 tgaacggata agcagaaagc ttctttttct cttccaaaag cagtggaata atgtctttgc 2862421 cgaagtcgtg gctagaataa gggttttgat cgtccatctc aagatactgt ttcaaaagcg 2862481 gccaattgaa tatataaatt cccattgagg caagattgct cttagggaat ttgggctttt 2862541 catcaaaatg tgtgatcgtc ccatctggat tggccttcat gatgccgaac cggcttgctt 2862601 cctcccagcc cacttcgatg acagagatgg tcacatctgc tttcttttca atgtgataat 2862661 caagcatttt gccgtagtcc attttgtata tgtgatctcc tgataaaatc agtacatact 2862721 caggatcata ctgattcaaa taattgagat tttcataaat ggagcttgcc gtccctttat 2862781 accatttgac ttctgatgac tcggcataag ggggtaaaac cgtcacgccg ccattatatc 2862841 tatccaggtc ccatgcactg ccgatcccaa tataggaatt cagctcgagc ggctgatatt 2862901 gcgttaaaat cccgactgtg tctatgcctg aattagaaca gttgcttagg gtaaaatcaa 2862961 taatcctgta ttttcccccg aaagatacag ccggtttggc catatttttt gttaatccgc 2863021 tgagacggct gcccttcccg ccggcaagga gcatggctac acattgtttt ttcatctttt 2863081 tatctctcct ctttttttaa ccgcccgtaa aatcgagatg ccgtaagggg ggatggtcat 2863141 cgtgatataa cacggtttat gatgaagtgc tcccttttta gccgataacg gctttttgtt 2863201 gatttgccct gagcctccat atgtttcact gtcactgtta agcacttcaa tgtattgagt 2863261 aaaaaaagga actccaacat catattgatg atagaccacg ggtgtaaaat tacaaatgat 2863321 gacaagcgcc tcaccgtgct tttggccata acgaataaaa gaaaagattg attgttcgtc 2863381 attatggaca tcaatccatt caaacgattg tgcacgatgg tcatgctcat aaaggatttt 2863441 gcttttttgg taaaagcgga gaagatcttg cgtaaaaacg ctggctttct gatgcatggg 2863501 gaaggagtcc aaaaaccaat caagctgttc tgtatctttc cattcatcaa attgagcaaa 2863561 ctctgatccc ataaagatca atttctttcc gggatgcact gtcatatagc ccagcaaaag 2863621 ccgatactgg gcaaatttct gccagtagtc gccaggcatt ttattgagaa gtgatttttt 2863681 tccgtatacg acttcatcat gagaaaacgg caatacaaaa tgttcactaa acgcatatag 2863741 taatgaaaaa gagataagct gatgacaatg ccgcctttct tcgggcggcg tctccatgta 2863801 tttcagtacg tcattcatcc atcccatatt ccatttataa tgaaaaccaa gccccccttc 2863861 ctcaacggca cctgtcactt gaggccattc tgtagaatct tctgcaatca tcatcacatg 2863921 gggatatgcc tctctcatgg tttgattgag tttttttaaa aaatcaacag catatggatt 2863981 cgtgtggcgt tcatcctgat ttggccaata caagatatta gccactgcat caaccctaaa 2864041 tccatctata tgatagaatt ccgcccagta caacgcattc gaaattaaaa aactatgaac 2864101 ttccggtttc cccaggtcaa agtttgccgt gccccataac cagttctccc gatcacgttc 2864161 ttctttgtat tcataaagcg gttctccatc aaacatataa aggccatgtg catctttaca 2864221 aaaatgtccg gggacccaat ccaaaatgac tccgatattt tgttgatgac attcatccac 2864281 aaacttcatc agatcatgcg gcgggccaaa cctgcttgtc gggctgtaat accccgttcc 2864341 ttggtacccc catgaacgat catatggatg ctcatacacg ggaagcagtt caatatgggt 2864401 aaacccatgc ttcttgatat aagggataag cgtctgactt aattctttat aggaataatg 2864461 cctgccatca gaatgcttct tccaagaccc aagatgcagt tcataaatga aaacaggttt 2864521 ttcatacagc gtcttagcct tctgtttctt ttgccatttt tgatcttgcc agctgtatcc 2864581 ttccaaatcg taagtaagtg acgctgtgtt tggtctgact tctgaataaa tagcgtatgg 2864641 atctgccttc agcctgatct caccgttatt cgtcacaatt tcgtatttat atcgttcctt 2864701 ttctcctata cctggaataa ataacgtcca aatgccatta tcattcactc tgtgcatcac 2864761 atgctcttct ccagaccagc tgttaaaatc tccagccact cgtacttccg acgcatgagg 2864821 cgcccacaca cagaattcat atccgctttt gccattcagc tcgcggtaat gcgagccaaa 2864881 cagctgatag cttttaaaca gactgccttc gtgaaaaaga taaacatcat gtgctgtcgg 2864941 gctggcagcg gccatgtaat catcctttct gacatcatag ttttcattta tagtatttat 2865001 tcgaagaaat aaaaaaaagc cctttcctga aagcgcttat acttatagac aattaacttc 2865061 attttctgaa gaaaaacgaa atatatggag atttttgtag tctgttttta aaataaagaa 2865121 caaaatctaa gacatatcat gatttataaa aacaaaaaaa ccttgcagga tatgcaaggc 2865181 ttctggatga cccgtacggg attcgaaccc gtgttaccgc cgtgaaaggg cggtgtctta 2865241 accgcttgac caacgggccg ataattatga tatctgtaat catatggcgg agaaggaggg 2865301 atttgaaccc tcgcgccgct tacacgacct acacccttag caggggcgcc tcttcagcca 2865361 cttgagtact tctccatttg gctccacagg caggattcga acctgcgacc gatcggttaa 2865421 cagccgatag ctctaccact gagctactgt ggaacaaaag tcatggtggg cctgaatgga 2865481 ctcgaaccat cgacctcacg cttatcaggc gtgcgctcta accagctgag ctacaggccc 2865541 atgacgatat agaaatggag cgggtgatgg gaatcgaacc cacgacatca gcttggaagg 2865601 ctgaggtttt accactaaac tacacccgca atttttattt ggggcgattg atgggaatcg 2865661 aacccacgaa tgccagagcc acaatctggt gcgttaacca cttcgccaca accgccaaag 2865721 catattgata aatggtggct cgggacggaa tcgaaccgcc gacacacgga ttttcagtcc 2865781 gttgctctac caactgagct accgagccta agtatttaaa tggcggtccg gacgggactc 2865841 gaacccgcga cctcctgcgt gacaggcagg cattctaacc aactgaacta ccggaccatt 2865901 ttaaaatttg gttgcggggg caggatttga acctgcgacc ttcgggttat gagcccgacg 2865961 agctaccgaa ctgctccacc ccgcgatgat taggaatatg tatggcggag gaagagggat 2866021 tcgaaccccc gcgggctttg acacccctgt cggttttcaa gaccgatccc ttcagccaga 2866081 cttgggtatt cctccgtata gtggtggacc ttgtaggact cgaacctacg accggacggt 2866141 tatgagccgt ctgctctaac caactgagct aaaggtccat tggtagcggc ggaggggatc 2866201 gaacccccga cctcacgggt atgaaccgta cgctctagcc agctgagcta caccgccaaa 2866261 tatttttgaa atcaagtgga gcctagcggg atcgaaccgc tgacctcctg cgtgcaaagc 2866321 aggcgctctc ccagctgagc taaggcccca agaatggtcg ggaagacagg attcgaacct 2866381 gcgaccccat ggtcccaaac catgtgctct accaagctga gctacttccc gatttcatat 2866441 agatcatggc gcgcccgaga ggagtcgaac ccctaacctt ttgatccgta gtcaaacgct 2866501 ctatccaatt gagctacggg cgcaaaactt aatgccgagg gccggacttg aaccggcacg 2866561 gtagtcacct accgcaggat tttaagtcct gtgtgtctgc caattccacc accccggcgt 2866621 ggatggtata gttggagcgg aagacgggat tcgaacccgc gacccccacc ttggcaaggt 2866681 ggtgttctac cactgaacta cttccgcaga aatggtgcgg atgaagggac ttgaaccccc 2866741 acgtctgtaa agacactaga gcctgattct agcgcgtctg ccaattccgc cacatccgca 2866801 acatgtaaat ggtgagccat gaaggactcg aaccttcgac cctctgatta aaagtcagat 2866861 gctctaccaa ctgagctaat ggctcttctt acaatagact tgaatattat atcatataaa 2866921 agtggtgccg gcaagaggac ttgaaccccc aacctactga ttacaagtca gttgctctac 2866981 caattgagct acaccggcat atatgtaaaa ccgatatgta taatgaaaaa tggtggagga 2867041 tgacgggctc gaaccgccga ccctctgctt gtaaggcaga tgctctccca gctgagctaa 2867101 tcctccatac ttgcactaac gtgcaattgc ttggcggcgt cctactctca cagggggaaa 2867161 cccccgacta ccatcggcgc tgaagagctt aacttccgtg ttcggtatgg gaacgggtgt 2867221 gacctcttcg ctatcgccac caaacaaatt gagagtgttc tctcaaaact agataacagg 2867281 tgtgacatca ttcaaaaata tggttaagtc ctcgatcgat tagtatctgt cagctccatg 2867341 tgttgccaca cttccacctc agacctatca acctgatcat ctttcaggga tcttacttcc 2867401 ttgcggaatg ggaaatctca tcttgagggg ggcttcatgc ttagatgctt tcagcactta 2867461 tcccgtccgc acatagctac ccagcgatgc ccttggcaga acaactggta caccagcggt 2867521 gcgtccatcc cggtcctctc gtactaagga cagctcctct caaatttcct gcgcccgcga 2867581 cggataggga ccgaactgtc tcacgacgtt ctgaacccag ctcgcgtacc gctttaatgg 2867641 gcgaacagcc caacccttgg gaccgactac agccccagga tgcgatgagc cgacatcgag 2867701 gtgccaaacc tccccgtcga tgtggactct tgggggagat aagcctgtta tccccggggt 2867761 agcttttatc cgttgagcga tggcccttcc atgcggaacc accggatcac taagcccgac 2867821 tttcgtccct gctcgacttg taggtctcgc agtcaagctc ccttgtgcct ttacactctg 2867881 cgaatgattt ccaaccattc tgagggaacc tttgggcgcc tccgttacct tttaggaggc 2867941 gaccgcccca gtcaaactgc ccacctgaca ctgtctcccc gcccgataag ggcggcgggt 2868001 tagaaggtca atacagccag ggtagtatcc caccgatgcc tccaccgaag ctggcgctcc 2868061 ggtttccaag gctcctacct atcctgtaca agctgtacca acattcaata tcaggctgca 2868121 gtaaagctcc acggggtctt tccgtcctgt cgcgggtaac ctgcatcttc acaggtacta 2868181 taatttcacc gagtctctcg ttgagacagt gcccagatcg ttgcgccttt cgtgcgggtc 2868241 ggaacttacc cgacaaggaa tttcgctacc ttaggaccgt tatagttacg gccgccgttt 2868301 actggggctt caattcgcac cttcgcttac gctaagcgct cctcttaacc ttccagcacc 2868361 gggcaggcgt cagcccctat acttcgcctt acggcttcgc agagacctgt gtttttgcta 2868421 aacagtcgcc tgggcctatt cactgcggct ctctcgggct tgcaccctaa cagagcaccc 2868481 cttctcccga agttacgggg tcattttgcc gagttcctta acgagagttc tctcgatcac 2868541 cttaggattc tctcctcgcc tacctgtgtc ggtttgcggt acgggcacct ctcacctcgc 2868601 tagaggcttt tcttggcagt gtggaatcag gaacttcgct actatatttc gctcgccatc 2868661 acagctcagc cttatgggaa acggatttgc ctatttccca gcctaactgc ttggacgcgg 2868721 atatccaata ccgcgcttac cctatcctcc tgcgtccccc cattgctcaa atggtgagga 2868781 ggtggtacag gaatatcaac ctgttgtcca tcgcctacgc ctttcggcct cggcttaggt 2868841 cccgactaac cctgagcgga cgagccttcc tcaggaaacc ttaggcattc ggtggagggg 2868901 attctcaccc ctctttcgct actcataccg gcattctcac ttctaagcgc tccaccagtc 2868961 cttccggtct ggcttcacag cccttagaac gctctcctac cactgttcga agaacagtcc 2869021 gcagcttcgg tgatacgttt agccccggta cattttcggc gcagagtcac tcgaccagtg 2869081 agctattacg cactctttaa atggtggctg cttctaagcc aacatcctgg ttgtctaagc 2869141 aactccacat ccttttccac ttaacgtata ctttgggacc ttagctggcg gtctgggctg 2869201 tttccctttc gactacggat cttatcactc gcagtctgac tcccaaggat aagtcattgg 2869261 cattcggagt ttgactgaat tcggtaaccc ggtaggggcc cctagtccaa tcagtgctct 2869321 acctccaaga ctcttacctt gaggctagcc ctaaagctat ttcggagaga accagctatc 2869381 tccaggttcg attggcattt cacccctacc cacacctcat ccccgcactt ttcaacgtgc 2869441 gtgggttcgg gcctccattc agtgttacct gaacttcacc ctggacatgg gtagatcacc 2869501 tggtttcggg tctacgacca cgtactcatg cgccctattc agactcgctt tcgctgcggc 2869561 tccgcatctt ctgcttaacc ttgcacggga tcgtaactcg ccggttcatt ctacaaaagg 2869621 cacgccatca cccgttaacg ggctctgact acttgtaggc acacggtttc aggatctctt 2869681 tcactcccct tccggggtgc ttttcacctt tccctcacgg tactggttca ctatcggtca 2869741 ctagggagta tttagccttg ggagatggtc ctcccggatt ccgacggaat ttcacgtgtt 2869801 ccgccgtact caggatccac tcaggagaga acgaagtttt gactacaggg ctgttacctc 2869861 ctatggcggg cctttccaga cctcttcatc tacctcgttc ttttgtaact ccgtacagag 2869921 tgtcctacaa ccccaagagg caagcctctt ggtttgggct gatcccgttt cgctcgccgc 2869981 tactcaggga atcgcatttg ctttctcttc ctccgggtac ttagatgttt cagttccccg 2870041 ggtctgcctt ctcatatcct atgaattcag atatggatac cactccatta cgagtggtgg 2870101 gtttccccat tcggaaatct ccggatcaaa gcttgcttac agctccccga agcatatcgg 2870161 tgttcgtccc gtccttcatc ggctcctagt gccaaggcat ccaccgtgcg ccctttctaa 2870221 cttaaccgtt aaaaagaatc actatgtgat atcttgtgtt actaattgaa tgtgatgtct 2870281 actgttatct agttttcaaa gaacacgttt cgaaggaatg atccttcaaa actaaacaag 2870341 acagggaacg ttctgtttat aagaccttgg gtcttatatt ccgtataata tccttagaaa 2870401 ggaggtgatc cagccgcacc ttccgatacg gctaccttgt tacgacttca ccccaatcat 2870461 ctgtcccacc ttcggcggct ggctcctaaa aggttacctc accgacttcg ggtgttacaa 2870521 actctcgtgg tgtgacgggc ggtgtgtaca aggcccggga acgtattcac cgcggcatgc 2870581 tgatccgcga ttactagcga ttccagcttc acgcagtcga gttgcagact gcgatccgaa 2870641 ctgagaacag atttgtggga ttggcttaac ctcgcggttt cgctgccctt tgttctgtcc 2870701 attgtagcac gtgtgtagcc caggtcataa ggggcatgat gatttgacgt catccccacc 2870761 ttcctccggt ttgtcaccgg cagtcacctt agagtgccca actgaatgct ggcaactaag 2870821 atcaagggtt gcgctcgttg cgggacttaa cccaacatct cacgacacga gctgacgaca 2870881 accatgcacc acctgtcact ctgcccccga aggggacgtc ctatctctag gattgtcaga 2870941 ggatgtcaag acctggtaag gttcttcgcg ttgcttcgaa ttaaaccaca tgctccaccg 2871001 cttgtgcggg cccccgtcaa ttcctttgag tttcagtctt gcgaccgtac tccccaggcg 2871061 gagtgcttaa tgcgttagct gcagcactaa ggggcggaaa ccccctaaca cttagcactc 2871121 atcgtttacg gcgtggacta ccagggtatc taatcctgtt cgctccccac gctttcgctc 2871181 ctcagcgtca gttacagacc agagagtcgc cttcgccact ggtgttcctc cacatctcta 2871241 cgcatttcac cgctacacgt ggaattccac tctcctcttc tgcactcaag ttccccagtt 2871301 tccaatgacc ctccccggtt gagccggggg ctttcacatc agacttaaga aaccgcctgc 2871361 gagcccttta cgcccaataa ttccggaaaa cgcttgccac ctacgtatta ccgcggctgc 2871421 tggcacgtag ttagccgtgg ctttctggtt aggtaccgtc aaggtaccgc cctgttcgaa 2871481 cggtacttgt tcttccctaa caacagagct ttacgatccg aaaaccttca tcactcacgc 2871541 ggcgttgctc cgtcagactt tcgtccattg cggaagattc cctactgctg cctcccgtag 2871601 gagtctgggc cgtgtctcag tcccagtgtg gccgatcacc ctctcaggtc ggctacgcat 2871661 cgttgccttg gtgagccgtt acctcaccaa ctagctaatg cgccgcgggt ccatctgtaa 2871721 gtggtagccg aagccacctt ttatgtttga atcatgcggt tcaaacaacc atccggtatt 2871781 agccccggtt tcccggagtt atcccagtct tacaggcagg ttacccacgt gttactcacc 2871841 cgtccgccgc taacatcagg gagcaagctc ccacctgtcc gctcgacttg catgtattag 2871901 gcacgccgcc agcgttcgtc ctgagccagg atcaaactct ccgataaatg gatcacaggt 2871961 taagttcacc gcatcctgcg gcgacacctg tgtgacctgc gtcgtgcagg ccctagtttg 2872021 actgactacg cacatcgcag tgcgattttt aaaaactgaa ttaacaggta cgttttgtct 2872081 tgtttagttt tcaaagatca tttcgttact tctcaatgaa gcagctttac taatataaca 2872141 ttcagcttct tttttgtcaa caactttttt caagttgttt tgaagcatct agtttgtgtc 2872201 cgctgtgcat cagcgacgtt taataatata acacctgtat ttatttattg caatagtttt 2872261 ttaaaaaaaa tctataaaac aaataaacta taatcctcgc catgatttct aaagcgtgtg 2872321 tatcatataa gtttcttaaa agaacatata catcagtcat gtgatcttgt tgtttttttc 2872381 gttttcttgt atagtagaaa cgaactaaat actgatgacc acaaggggag cattaaagct 2872441 gagagtgagc ggtttcgttc tgaccctttg aacctgttag ttaacgctgg cgtagggatg 2872501 tggcaaagtc aaatgaattg cagatcgtaa agcagtgcgt ggaacttttc tcatccttcc 2872561 gcgtgctgct tttttgttgt ccttttggtt gtctgtcaat ggaaggagat agatatgaat 2872621 caatctaagc aactggttcg ccttattgaa attgccatta tgacagcggc agccgttatt 2872681 ttagacattg tctcaggaat gtttcttagc atgcctcaag gaggctcggt ctccatcatg 2872741 atgattccga tctttttaat ttcgtttcgc tggggtgtca aagcaggtct tactacaggt 2872801 ttgttgacag gtctagtaca aatagcaatc ggaaacttgt ttgctcaaca tcctgtacag 2872861 ctattgttag attacattgt cgctttcgca gcaatcggca taagcggctg tttcgcttct 2872921 tctgtccgta aagccgctgt atcaaaaaca aaagggaaat tgattgtttc agtggtcagc 2872981 gcagttttta tcggcagttt gctgcgctat gccgcgcatg tcatttcagg agctgtgttt 2873041 ttcggcagct ttgctccaaa aggaacaccg gtatggattt attctttaac ttataatgcg 2873101 acttacatgg ttccttcatt cattatttgt gcaattgtcc tatgtttatt atttatgaca 2873161 gcaccccgtc tgcttaaaag tgacaaagcg taaaagtaac aatcccccag cgaattccgc 2873221 tgggggattt ttcgttatct gttaagaagt gtttttaaag ctgaaagatc cggccagcca 2873281 agacctactt ctttcagcct tactccggca atttcaaagt tgtcctccgc tactctttca 2873341 ggtgaatagg cctgataaaa tataatcgag ggattctgct caataaccca aacaaacata 2873401 cttgaaaaac catgttgaag caaaaactcc gctccttttg ctaagagcgc cctgcctgca 2873461 ccttgccgct ggcgctcttc cagaagataa atagcgtata actcgccgtc atagccttct 2873521 tgttcagagc gaataggtcc aaatgaagca aagccgaata ctgaaccctt ttcgtcctga 2873581 gcaacaaata ctccctttaa cgagcgactt ttccatttgt cttcaaattc cttatagttc 2873641 aggctgttta aataatcaat cgggataatt tcgtggtatg ttgtcctcca gctgtctaca 2873701 tgcacttttg caatgtcctt tatatcctct aacttcgctt cacgtacagt taccatacgg 2873761 ttctgccctt tccttactct gatttttgga tcgttttggc ttctttgatt tcatttgtta 2873821 attcattaat gctttgtttt acgtttcctt ttcctgaaaa gttctcaagc atttctttta 2873881 catcaattcc tgaggatgct tttaaacttt cttgcagact tgacattaag ttcgtcgcat 2873941 agctggttac tttgtttgct ccgcttgatt caccgcttcc tcctgtatcg acaacggtga 2874001 ttttatcaat atttgaaaga ggtgccgctg cttgtttcgc gtattccgga agcattttga 2874061 caatcatatc gaaaatcgcc gcctgcccgt actgttcaaa ggcggccgca attttctctt 2874121 ttgcttccgc ttctgcaaga cctttcaggc ggataacctc tgcttctgtc tctcctttcg 2874181 ctttttccgc ttctgctttt gctagcccgt caattcttac tttttccgcc tcagcctttg 2874241 ccattgcttc aatactgtac ttcttggcat cggcttccgc gagctgtttg gctttctcag 2874301 ctgctgcgga ctgctcaaca gaataacggt ctgcatcggc ttttttcttt acctctgagt 2874361 cgtattgacg ttcacggcga agaatttctt tttcttctag ttctatttgt ttttggcgtt 2874421 cgataatttt aacctgcatt tcctgctctg tgacttgctg gcgcgctcgg gcagtctcta 2874481 aatcatatgc ttggtcggca ttcgcttttg ccgtatcttg ttctctgcgg aattcagcca 2874541 ttttgagctg attgattttt tcagcttcag cgatttccgt cgcccgttca agttctgatt 2874601 tttttgcgtc tttatcggct tctgcccgct taattcgggt ttctttatca gcctctgctg 2874661 ttgcgatatc agcatcgcgt tttacttggg caattctcgg tttccctaat gattcaagat 2874721 aaccgttttt atcacgaaca tctttaatgg taaacgagac gattacaagt cccattttcg 2874781 cgagatcctg tgaagcgaca cgctgcacct cttgagagaa tttttctctg tttttataga 2874841 tttcttctac tgtcattgag ccgagaatgg aacgaaggtg gccttctaaa acctcccgcg 2874901 cttcctgctc acggtcgtct tttgatttcc ctaaaaattg ttcggccgct gtagcgattt 2874961 ctcctataga accgccgatt ttaataatcg cagttccatc ggccattact ggcactcctt 2875021 gttctgtata gacttcaggt gtcgaaacat cgagtttgct tgataatagg cttagcggct 2875081 ctgcctgctg gaagacggga aggacaaagg ttcctccgcc gcggacgatt ttaatacggt 2875141 tgccgccttc atcgacatga acatttttat tacccagata gctccctgtt acaattaacg 2875201 cttcatcagg ccctgctgta cgatacttcg taataaacac agctattagt gcaattaata 2875261 aaaagaatac aactccgatg atcattataa tcggcattgt catatcaaat tcctcctttt 2875321 atgttaaatg ggttcatgcg gagtaaccga aagaactccg ttgttaatat ctacgactaa 2875381 caccgttgtc ccgtaactga tctgctgatt atcaaaactg accgctgact ttgaaatggt 2875441 cccgcctatc ccttctatga ccacttcacc aaacccgtca accggcacag ctgtaatcac 2875501 tttaccgagt cttcctctga gatcatcttc tctatatgcc aatgattctt ctgcagatga 2875561 taatggcacc agtacaaaga tgtgaagcaa taccaccagc atgatcgaaa ggatgcaaga 2875621 taaaagcgca atcagcaagc ttgacagagg caatacaagt tcacctatat atccgcccgc 2875681 tgaaaaacat gtaaaaaatg agagcactaa tgtcggatta agaaacggaa tgccttctga 2875741 cagccctgaa aatacatctc cgaaaaacag gaataacagc gtaaggctgc ccgcaataat 2875801 aagcgtataa agatacattg tttgtatagg tactccaaat aactccaact tcctcatcct 2875861 ttcttcatca atgcattgat gaacggctgc cgttaccatt tatacgagac acctcgggaa 2875921 aagtttcaaa attttaagac aaataaccca tttgaagtgc tttataaatg ataattgctt 2875981 atatatatgg taatgtcatt ttaggaggag atatgatgag tatctttaat gaagccagat 2876041 tagaaacgtg gaacgaattg aaaggacttt ctgacgaaaa gctgaatcaa aagccttctg 2876101 ctgaagaatg gagcatacgg gaagttcttg accatttgaa aaaaatcgat atgaccgcac 2876161 aaaaaatgtt gaaggaacgt gtaaaggacg ctccgattaa agaaattgaa gaaaaaccgc 2876221 ttgaagtagc acaggacaga aataataaac ggaaagcccc gagtcatctt gagcctgcgc 2876281 atgattttat ttcaggcagc caaatgaaac gtgagcttga tgtggtaaga gagcagctga 2876341 ctgctgcgat tgcctctctg aaagaagaag attttgaaag agtgcttccg catcctgtgt 2876401 ttcaagagct gactgtcaga cagtggatcg attttatcgg ccatcatgaa aaacggcacc 2876461 tcagccaaat gaaagaaatt aaagaaaaga tagaaagggc ctgatttaat cagacccttt 2876521 ctgcttttcg tttgactttt cgctgatagg aatgaacttc tatttcatca cctgtgtaaa 2876581 cagcaccagg tctctccaca atacagacaa tccctctaat gcccagtgcg tggcggacga 2876641 aagccgacgc cagcttcggt tggtccggat aataagactg aatgacttct cccggctgga 2876701 tacacggatc attttcgccc tcacacagca gagccgctcc gctcggaaaa ataatccggc 2876761 ttccttcttt taatgaagta agatctggca taccgctgac tgccacattc gccccgagcc 2876821 attccggcaa aattctcggc actcccattt ttaaagcgat ttcgttgcat tcctctattg 2876881 aaacaattga aatttgtctg cggttgaaaa tttcagtccc tcttgaaaac attggttctc 2876941 tggctcccgc ttttttggtc aggccaaaat gcaagtcgcc ggggatgccg ccataatcaa 2877001 aatcaagctt gtccatttgc tttgttacga agctttttgt atctgcgata tataagcctt 2877061 ccgcttttgc agtcatacgc ttccacatca gctggcacct tccttcttat ctaaaatttc 2877121 cacctatgct tcattatccc aaaaaatccc gctctgtaaa ggagcgggat tttgattata 2877181 ccgttttagg cgtaaggtta aagcagcgtt tgtagatcca gttgtatgct ttttcattta 2877241 aatctctagg gtttccgaag gtttgcggat ctttcattgc ttctttagac aagcgttcga 2877301 tcatatcagg tgatactccc tgctcttcta aagtcggcac ttctaaatct tcgaccagat 2877361 catacatcca attgacagat gctttcgcag cttcttctgt tgtcatcttg cttgtatcaa 2877421 taccgaacgc tttcgcaata cgcgcaaact tctcaggata gcccttccag ttgtattcca 2877481 tgacagggcc catcatcgcc gctacacatt ggccgtgagc gactgggata ataccgccaa 2877541 gcgtttggct catcgcatga gcagcgcccg ctgattcact tccgtaagaa agaccggcaa 2877601 gcatcgcagc ctgcgccatt ccgtaccttg cttccagatc ctctccatca gcaaatgccc 2877661 tcttgatgta atgagcggca tactcaatcg ccattaaggc aaccgcatcc gtgattggct 2877721 gtgcaaattt cattgtatag cactcaatgg catgggcgag cgcatcaatt cccgtcatag 2877781 ctgttacatg cggaggcatt gaaacatgaa gctcaggatc aatgattgtc aagtgcgctg 2877841 caatcagcgg accgcccgtg ttgaatttga attctctttc ttcatctgtg ataaccgccc 2877901 attgggttac ttctgatccg gttccagctg tagtgggaat tgtcgtcagc ggaggaatgc 2877961 ggttttccag cggttttttc ccatctgccg cttcataatc aagcacgctt ccttcgtgag 2878021 tcgcttctac tccgattgct tttgctgtat ccatggagct tccgcctccg actgccacca 2878081 aaccattaca gttctctttt ttgtaaagct cagatccttc attcaccaga cggacaggcg 2878141 ggtttggctc aactttatta aagagtacca cttcaatgcc tgcttcttta agtgattcga 2878201 ttacgggatc agcaacaccg gctttataaa tcccagggtc tgtgacaagg agcgcttttg 2878261 aaacgcccag tgcagctact tcctcacccg tatgcttgat ggctccgatt ccatgcttaa 2878321 tcacagtcgg aatttcaaat gtgtggaatt tctgcatgct ttctaccttc atatttaatg 2878381 tcatcatcaa tctccccctc ttatgaatta aaccagttaa ccgctgccgg ttttgtattg 2878441 cggtatacat gtttgacttc tgtgtattct tcaaggccta tttttccaag ctcgcgtccg 2878501 aacccggatt gcttatatcc gccccatggc gcttgtgcaa agtacggatg aaaatcgttg 2878561 atccaaacgg ttcccattct caagcgggct gctacccgtt cgcacttttc aatgtctttt 2878621 gaccataccg ctccagccaa gccatagatg gtatcattcg caagctcgat tacctcttct 2878681 tcagagctga aggtttcgac tgtcaataca ggaccgaaaa cctcttcctg aacgattctc 2878741 atgtcagaat tacagtttga gaaaatagta ggttcataga aaaagccgtt ttgaagctca 2878801 ggatcttccg ggcgtttgcc tcctgtctcc agcttcgcgc cttcctctat tccgatctct 2878861 acatattttt ctacctttgc cctgtgctcc gccgaaataa gcggaccgct ttctgtctca 2878921 gcatgaaaac cgtttccgag ttttatgcgt tttgcccgtt tgaccagctc cgccaaaaat 2878981 tgatcatgaa tggcatcctc aacaagcaag cgggaacctg cagagcatac ttggccggcg 2879041 tggaaaaata cagcgtttaa ggcctgatca accgcaactt ctaaatccgc gtccttgaaa 2879101 acaatatttg ggtttttccc gccaagttca agggcgattt ttttgacgtt tccgcttgcc 2879161 gcccgcatga tttttttgcc tgtttcaatt ccgcccgtaa atgaaatcaa atcgacgtct 2879221 ttgtttacgg caagctcgtc gcccactgtg gctcccggtc caagaacaag atttgcgaca 2879281 ccttttggaa caccggcttc ttccatcagc ttaaagactt tgattgtcgt cagcggcgta 2879341 atctcactcg gcttcatgac gattgtgttt cctgcggcca gtgcaggggc gattttccag 2879401 ctcgcttgaa ggagcggata attccatgga gtgatctggc cgcaaacccc gattggctcc 2879461 ctaataattt tgctttctga atcaggaatc ggagatgaaa tgatctctcc gccatctttg 2879521 tctgccaagc cggcgtaata ttgaaaaaca ttggcgatat cgtccatatc ggccttgctt 2879581 tcttcgagtg tttttcctgt atcaagagat tcaagctcag ccagctcctc aagatcgcgt 2879641 ctgattaatt ccgcaatttt cagaacaatt tttccgcgtt caagcccgga tagcgatgac 2879701 cattctcctt tgtcaaatgc tctacgtgcg gctgcgattg ctttgatggc gtcctctcgc 2879761 cctccctcgc ttacagttgc aatttcttct tgattaaatg ggttgataat actgcggatc 2879821 tgttcttttt cggcactgat ccattctccg tcaatgaata atgtttgact catataagcc 2879881 tccttgacgt aaataaagtt tgttaaataa aaatttaatg tttttaacaa ccttaatcta 2879941 acatatggtt tttaaactgt caaagtccca ttttgatttt tctttttgac ttttcctcat 2880001 gtttcgttaa gataaagaac ataaagaaat aacttaacga atttaatttt ctaaaggaaa 2880061 agagggtcag tatggatgaa aatccagaat ttgcagctat agaacaggct cgggatcttg 2880121 ttattgactc cattgctgaa acgatggatc tttacggaat tacccgcagt gtcgggattt 2880181 tatatgggac gatgtatatg agggatgaga tgacgcttga cgaaatgcgt gaggagttgc 2880241 aaatgagcaa accaagcatg agcactggcg tcaaaaagct tcaagactta aatgtagtga 2880301 aaaaaacatt tcaccggggc atccgcaagc atacatttgt ggctgagaag gatttcttta 2880361 aatttttcac aaatttcttt ccacctaaat gggagcggga ggttcaagtg aatgtaacag 2880421 cgatcgagga agctcaagct gatttacaaa aggttttatg caaggaagat ctcgatgagg 2880481 atatcaaaaa tgaagcactg cagttatatg atcagctgga aagctctaaa gcttactatg 2880541 actggctgaa acggcttgct gaatcggtgc agaccggaga aatttttaaa tttataccgg 2880601 tcgaaacaaa gtaaagcaga aaacgcctgg gaaactaggc gtttttttga tgtaactact 2880661 acaaatttga aaaatacggg aaaaacaccc catttacttc caaaatattt gatggtaatt 2880721 ttatgtaggt aaaatttgta tttggccttt cagaggaggt gaaaagcggg caggcctgtt 2880781 taatttatca ttttttaggg ggaattttgt tatgaaacgc aaattattat cttctttggc 2880841 aattagtgca ttaagtctcg ggttactcgt ttctgcacct acagcttctt tcgcggctga 2880901 atctacatca actaaagctc atactgaatc cactatgaga acacagtcta cagcttcatt 2880961 gttcgcaaca atcactggcg ccagcaaaac ggaatggtct ttctcagata tcgaattgac 2881021 ttaccgtcca aacacgcttc tcagccttgg cgttatggag tttacattgc caagcggatt 2881081 tactgcaaac acgaaagaca cattgaacgg aaatgccttg cgtacaacac agatcctcaa 2881141 taacgggaaa acagtaagag ttcctttggc acttgatttg ttaggagctg gcgaattcaa 2881201 attaaaactg aataacaaaa cacttcctgc cgctggtaca tatactttcc gtgcggagaa 2881261 taaatcatta agcatcggaa ataaatttta cgcagaagcc agcattgacg tggctaagcg 2881321 cagcactcct ccgactcagc cttgcggttg caactaatgt aaaagaccgg ttaacgccgg 2881381 tcttttttgc gttttaccct cccctttttc tctaatcccc gttatctttt ttctggttta 2881441 aaatttaaat tgacaaacac tagaaacagg agtaaattct tgagtgttca atttcataca 2881501 gtctctttta ccgcttaatc aaacacgaac gggggaacca acgattggct gttttattaa 2881561 cagccttggg gtgaatctta ctaagtaaga gggggtactc tgaatcccta atccgacagc 2881621 taacctcgta ggcgtataca gagaggaggt ctattatcgg ccattctttg caatggtctt 2881681 ttttgtttca aaaacgttaa ttcactaagg gagatatgaa cattgggaag aattaaaaat 2881741 aagcaatttg ccgtgatcgg gctgggccgg tttggcggca gcatttgtaa agaacttcat 2881801 agaatggggc atgaggtcct tgcggttgat atcaacgaag aaaaggtcaa tgcatatgct 2881861 tcttacgcca ctcatgcggt aattgccaac gccaccgaag aaaacgaatt gctttcatta 2881921 ggaatacgca attttgaata tgtgattgtt gccatcggag caaatattca agcgagtacg 2881981 ctgaccaccc tattattaaa ggagcttgat attccaaata tttgggtgaa ggctcaaaac 2882041 tattatcatc acaaggtgct tgaaaaaata ggcgctgacc gcattattca tcctgaaaaa 2882101 gatatggggg ttaaaatcgc acaaagcctt tcagacgaaa atgttttgaa ttacattgat 2882161 ctatctgatg aatacagtat tgtcgagctg ctggctacgc gcaagcttga ttcaaaatcg 2882221 attattgacc tgaatgtaag agcaaagtac ggctgcacga tcctggccat taaacatcat 2882281 ggagatatct gtctttcccc cgcgcctgaa gacatcattc gcgagcaaga ttgcctggtg 2882341 atcatgggcc acaaaaagga tattaaacgt tttgaaaacg aagggatgta gacaaaggtg 2882401 acacttcaaa aggataaagt gatcaaatgg gttcggttta caccgcctca agtgcttgcc 2882461 attggttttt tccttaccat tatcatcggg gctgtcctat taatgcttcc gatttccact 2882521 acgaagccat tgtcatggat agatgccctt tttactgcgg cttccgctac aactgttaca 2882581 gggcttgctg ttgtcgatac cggcactcaa tttacggtat tcgggcaaac agtaattatg 2882641 gggctgattc agattggcgg gcttggattt atgacatttg cggtcttgat cgtcatgata 2882701 ttaggaaaaa aaatcggctt aaaagaacga atgctcgtcc aggaagcctt aaaccagccg 2882761 acaatcggcg gtgtcattgg ccttgtcaaa gtcctgtttc tgttttcgat cagtattgaa 2882821 ttgatagcag cactcatttt atccatccgg cttgtacctc aatacggctg gtcatccggc 2882881 ttgtttgcaa gtttgtttca cgcaatatct gcttttaaca atgccgggtt ttcgttgtgg 2882941 cctgataatt tgatgagcta cgttggcgat cctacagtga acctcgtgat tactttctta 2883001 tttattacag gagggatcgg atttacggtt ctgtttgatg tgatgaaaaa tcggcgtttt 2883061 aaaacttttt ctttacatac aaagctcatg cttacaggaa cgctgatgtt gaatgcgatc 2883121 gctatgctta cggtctttat tttagaatac agcaaccccg gcacgctcgg ccacctgcat 2883181 atagtggata aactgtgggc ctcctatttt caggcagtga cgccgagaac cgcagggttc 2883241 aattctctag attttggaag catgagagaa ggaacaattg tatttacttt attattgatg 2883301 tttatcggag caggaagcgc atcaacggcg agcggcatta agctgactac gttcatcgtg 2883361 attttaacat ctgttattgc ttacttgaga ggtaaaaaag aaacggttat tttccgccgt 2883421 tccatcaaat atccgattat cattaaagct ttagctgtga gcgtcaccag tttgttcatc 2883481 gtgtttttag ggattttcgc cctgacgatc acagaacaag cgccatttct tcaaattgtg 2883541 tttgaaacct tttccgcatt cggaactgtc ggccttacga tggggcttac tcctgaactg 2883601 acaacagctg gcaagtgtat catcattgtc atcatgttta tcggaagaat tggtccttta 2883661 acgttcgtgt tttcattcgc aaaaacagag caatcaaata tccgttatcc tgatggcgaa 2883721 gtgtttacag ggtgatatca aaaaaatccg gcgtgcagtc gccggatttt ttatgattcg 2883781 atatgagatt gattttgtct tttttcctgt tccgcgatga tttcgttatc ctccgcgtta 2883841 tcacgggtca ctttttgcgt aagaatcgca ccaactgcta caagtatcat aacagcgatg 2883901 taataacctt tttcattgag ttccagatta tcagcattat agagtccgat actaaacaaa 2883961 aatactcccg caaaaaaagt aaaataagct agtactgtaa aggcaaccgt gtttctgcgt 2884021 ctatatttct gcacctttgt tccctcccga aagcatagtt aaaaagtgat aacttccgtg 2884081 gaatattata cctcaaattc cccggaatgg aacaaagaat taaaaatacc agtaaaaagg 2884141 gcttaggttg cctcctttat ttcaacagct gaatcatcaa tccagccgat aagtttatca 2884201 ttgatttgga attggtacca tacagactgg cctttctgtt ttttagacac aacctttatg 2884261 tctttgccga cgtaagattg ggcagaggta agccttatgg accgatcatc agtagaaggc 2884321 ttggaccata cgtcttgaac ggcactgtct ttaatagagg cgtttaaatc cacagatttg 2884381 agggatggat ttacctcatc gtactcatct aaatcgtatt tttccacaat agcgctgatt 2884441 ttgtcagcgt agtcagggtc tgtagcatat cctgatgttt gcagggcggt tgccgcttcc 2884501 ttataattcc ctgcctcaag caccggttta tacttctttt tattccacga tgtgccacgg 2884561 acgaacaatt gggcgtgatc atccatagat tcaaaaaacg tgctgtattt tcgaaacttc 2884621 gcgcgaatgg tttttctttt ccctttttca acttcgtccg tttccatcgt gacatgatgg 2884681 cctttataat tcccttttac gccaaaaagg ttgttggcct tagcagccag ttcactgttc 2884741 ccccagtccg attcgagaat ggcctgagca attgtgatgc tggggagaac atggtatttt 2884801 tcatacaaaa tttgggcatg tccggacaga ctgtctataa atacttgctg ttcatcgatt 2884861 tcttcagttt ctttggatat ttcaatcggt tttgataaag ttgtcgctaa aacaaacaga 2884921 gctagcggaa tcgatacaag gaaaaatagt gaaatcaaga gtttacgttt tttaagtttt 2884981 ttacgggcca tgaaaacctt ccttcgaatt aaaagattac gaatgtaaaa gaatctacct 2885041 tttagaattt tacttgcact tctaatattt ttcaattctt tagggataaa gttgggaaaa 2885101 gattgcaaaa taaaaacctt ttcgctcaat gaaaaggttt ttaccatgtt tctatttttg 2885161 taaatttctg agtgcattcc gatattccgt atcatttatt actttatatg atttgacagt 2885221 tgccttcgac aaaccttgtg ctgagacggc cggtttttcc ggagctgttt tcgctttatc 2885281 atgtggttta tgtgccagct tgtgccccat tccagtggca ttcatacaaa atgacaggca 2885341 gacgagcagc acgctaagga taaaagaaat gaagaagaga tcatgataag cagtcatcat 2885401 agaatcctgt accgaaccgc tttgtctggc agcatctttt ttcgtgaaaa agccgatgag 2885461 aatgggaact cccatataga caaacaatct taaaaactga acagctgtca ttctcttgac 2885521 caaatcaggc agcgggcctc ccatggcagc tcccatcagc cctgcggcga ctgtcaggcc 2885581 tgttcccgct gcaagcatga taaacagtgc cgcgaacata taaagagatg atcgatcctg 2885641 tatatgcagc cattgaaaat tcacaaaaac gagaatgagt ccgccgataa taccgagcat 2885701 ccctggtccg actttatcgt ataacagagc gctcaaaatg gccgcgatcg ccactccgat 2885761 taaaagagtc aagcttaaaa gaatgagatg ctcctgagaa atatcataca tttgacggag 2885821 caagccttga aaagcagaaa ggctgacagc taccgttatc gtccctgcag ctatgatcaa 2885881 taagccgagc accggttttg gcagcagcat cagtttaata gatatgaagg ggtttttcac 2885941 tttatattcc acaatcaata gaccaatgag caaacataac gtcaccccga aaccaatcca 2886001 tacataaccc gatgacagcc cccatttttg cagaaaaatg aatgaaaccg ctgaggctgc 2886061 ggcaaggaag acagataaaa gaattcccgc acgatcaagc ggctgttctt gatccgccgc 2886121 tccgtgatgc tcatcatgaa gaaagaaata gctcaccgcg acaccgatca gggacaaggt 2886181 gccaaagatg aaaaacagcc atctccaatg cccgcagctt gttgcaatgg ttcccaggat 2886241 tgtaccgatg ataacagaac catagaatcc cccgatcagc acaagcagtg catagttcct 2886301 gcgttcaatc gggaatgaca gtacaagcat tggaatcata atcatcagca tgacgcctgt 2886361 tgccgcccct tgtaaaaagc gccctgccgc catcaatgca atatcgcctg aacatgcgat 2886421 gagcagtgag cctagtataa agacaggtaa tgaagccaga tagacgggac gagcaccgaa 2886481 ttttttcctc agcagcggtc ctgccggaac taacaaggca aaggccatat tgccgatcaa 2886541 tatcggattt actgatgtaa agacacttgt tccaaccgtt ttctgaacaa ggccttgaac 2886601 tgacgacaat gccgtgttag acatcaatcc cggcccgacc gctaagacgg cgagcaaaga 2886661 aatcacccaa tagtgttttg tcttcatgtt gtcatccctt cctatatgaa tacatgcgaa 2886721 acacatcatt ttttgaaaac aaaagaagct aatagatttt gcataccatt agctttcatt 2886781 ctaatattct ccctttcagg ggaaatgata ttattttatt ataattatgt gaatgaatga 2886841 gcatataatc aaatattatt tcaaatcgat tgtgttttgt caatggagta aatttcaagc 2886901 acaacataga aagcttgaaa gcttttcccc gatattgtgt ctagaactgc acttatgaat 2886961 ccctgctcgt tccctcaagc gaattaaagc aggccgtttt aatcctttca atccactatt 2887021 ccaactaata aactcaaata agttggtgat aagacaacat tttaccccca catttttttg 2887081 tgttcactgg gcgtttgccg cctctaaatt gtatatgggt aaataccatg aattaaccta 2887141 tgaaatacca atgtaaggga ggcaaaaacg aatggaactg tatgagtgta tccaagacat 2887201 ttttggcggc ttgaaaaatc catcggttaa agatttagca acgtctttaa aacaaattcc 2887261 aaacgcagca aaattgagtc aaccgtatat taaggaacca gaccagtacg cttacggccg 2887321 aaatgccatc tatcgaaata atgaattgga aattatcgtg attaacattc cgccaaacaa 2887381 ggagacaaca gtacacgatc atggtcaatc cattggttgt gcaatggtgt tagaaggaaa 2887441 gcttcttaat tctatttatc gttcaaccgg cgaacacgca gaactctcca attcatactt 2887501 tgtccacgaa ggagaatgcc ttatttcaac caaaggttta attcacaaaa tgtccaatcc 2887561 aacatctgaa cgaatggtgt ctcttcatgt ctactcccct cctttggaag acatgacggt 2887621 ctttgaggaa caaaaggagg tattggaaaa ttcatgattg acagataaac tgctcacttt 2887681 gacttcactc aactggagga ttcagagaat gaaacctttt cctcaaaaca aaaaaaccct 2887741 tatcgaataa gggtttaaag gtatggagcc aagggggctc gaacccctga cctctacgct 2887801 gccagcgtag cgctctccca gctgagctat ggccccgtat gtaacgtcat gtttattata 2887861 gatgatttta ttttgaaaaa caagctgttt cctcttgaat tgacagaaaa aataaggctc 2887921 ggaaaagagc cttatttttc gacttacatc atgatcaaaa gtaaaatcac accgagaata 2887981 attcgataga ttgcaaatgg gacaagtttg attttgttaa tcagccttaa gaagaaacgg 2888041 acgacaaaca gtgcgaccac aaaggcacag ataaagccga cgatgaaaaa cggcatcaga 2888101 tccgaactta agctgtccca atgcttcacg aggcttagaa agctggctcc catcatgatc 2888161 ggcatcgcca taataaacgt aaagtcggct gcagctcggt ggtttaatcc gagaataaca 2888221 ccgccggaaa tggttgaacc cgaacgcgag aaaccaggcc aaagggaaag acattggaat 2888281 aagccgacgg ctatcgcctg tttataggaa atgcggtcga gtgtgtctgt cgctgttttc 2888341 cgtttattga cccagtcagc aaaaagcatg aggattgccc cggcaattaa accgatggcc 2888401 acagttttaa cggaaaataa atattcatca atgtaatctt caaacaaaaa gccgagaaca 2888461 gctgcaggca cgagtccgac ggcaatttgg gcaatgctta atttatgtcc ctgctcctgg 2888521 tcgcttgtaa tatttttttt caagcccagt aaatttaaaa ttcggtcttt aaacacgata 2888581 gctactgcta aaatggagcc tagctgaata accaccttga atgagttagc agcttcttct 2888641 gacatcagat tacttgattt tagccagatg tcgtctacta tgatcatatg tcctgtcgaa 2888701 gaaaccggcg cgtactctgt taatccttct acgattccta aaatggcggc tacaaacaat 2888761 tcccatagag tcatgatttt gattctcccc attagacatt tattttttta cataacggga 2888821 gcttcccata aatggaaagc ccgtcttata taactataaa cgaaaatcac actttatgcc 2888881 ccggcgtatt ttcatttttt tcttcatcgt ataaatgtga ctgcatttta aaccagtcaa 2888941 ataaatgtgt cgtaatgact ttggcaaccg catagccggg aatcgcaaga atgattccaa 2889001 caacgccaaa cagcttgccg gctgttaaca gcagaaaaat aatcgtaatc ggatggatgt 2889061 gaaggttttt tcccataatt tgcggagaga tcagcttccc ttcaatcagc tgaacaatcg 2889121 tccaaacgat caccagctta agcagcatga gcggcgatgt cactatggca atgataatcg 2889181 caggcgtaat ggcaatcgtt ggccctaaat atggaacgat gcttgtgcaa gccgcaatga 2889241 ctgcaagcaa tgaagcataa tccagcccga taatcaaata accgataaac agcaaaaacc 2889301 cgatacagaa gctgacaatg atctggcctc tgatataaga gcttaaccga tgattcattt 2889361 cgcttaagac tgtatatgtc tgttctttca atcgagtcgg cacaaacttc agtatgtaga 2889421 ccggtaattt tcttccgtct tttagcaaat aaaatagaat aaacggaacc gtgacgatcg 2889481 aaatgataat ctcagtcagt gcgccgataa aattcccaac accggtaaag gtgctgttca 2889541 cgatcgtcgc tgcctgatcc gaaacctttg tagcaagatc agatatatta atgttcatcg 2889601 tttgctgggc ctgattgacg aagttgctgc caatcagctg tttcgtctga ttttctacga 2889661 cgtccacata tctcgggata ttgtcaatca aactcataat ttgttctttt aagaagggaa 2889721 tgatcgacac gatcgtgatc gtgatcagcc cgataaccaa taggtatagc agcaatatag 2889781 aatagattct tcttattctt cttctctcca gaaaatcgac gactgggttt aacagataaa 2889841 aaacaatgcc tgtcaaaata atcggaagtg atatcgtttt gagcagaaca ataatcgggg 2889901 tgaaaataaa tgatgttttt gtaaatacta gaatatttaa accaatcagc agcagcacaa 2889961 gcaaaaataa aacaaactta ttatccaaga agaatcgctt gaatctgccg ctccatgttt 2890021 gcaacgtctc cactatcgtt cctccgtcat acatagttta attaaattgt acactatcgt 2890081 ccctataatg aaaaataaaa accgttaatt gctggaaaag ctttctcggt tttaacattc 2890141 tatttatatc tatcatgtga ttttgttctt tttaagctat aatttagcta tatcatgcaa 2890201 aaggagcgat acgagtgata cgttttgcaa taataggaac caactggatt acagaccgct 2890261 ttcttgagtc agcagcggat atcgaagatt ttcagctgac tgctgtttat tcaagatcgg 2890321 ctgaacgcgc tggcgagttt gctgctaaac acaacgctgc gcatgccttc tcagaccttc 2890381 aggaaatggc ggcgagcgat tgctttgatg ccgtatacat agcgagcccg aacgctcttc 2890441 acaaggaaca agccgttctc tttatgaacc atggcaagca tgtgctttgt gagaagccgt 2890501 ttgcttcgaa tacaaaagaa acagaagaga tgatctcagc ggctaaggca aacggcgttg 2890561 ttctcatgga agcaatgaag accactttcc tgccgaattt caaagaactg aaaaaacacc 2890621 tgcataaaat cggcactgtc cgcagattta ccgcaagcta ctgccagtat tcctcacgat 2890681 atgacgcgtt cagaagcgga actgttttga atgcgtttca gcctgagctt tccaatgggt 2890741 cattaatgga tattggcgtc tattgtattt atccggctgt tgtgttgttt ggcgcgccga 2890801 aggatgtaaa agcaaacgga tatgctttat cctccggagt ggacggagaa ggaactgtca 2890861 ttctgtctta cgacgggttc gaagctgttc tgatgcattc caaaatctct acttcctatg 2890921 ccccggctga aatccagggt gaagacggga cgattgtaat cgatacgatt caccggcctg 2890981 aacgtgttga aatccgctac cgggacggcc gccttgaaaa catcgcgatc cctgatccta 2891041 aaccggcgat gttctatgaa gcagaagaat ttgtcacgct tataaaagag aataagctgg 2891101 aatctgaaga aaatacattt gaacggtctt tgaccaccgc aaaaattatg gaagaagcaa 2891161 gaaagcaaat ggggattgta taccctgctg atcaagctta aaaaaatccg cccgcgtgca 2891221 aatgccgcgg cggatttttt attagacaat cggagaagat gccttccttt ttaaaagcac 2891281 ctgttgctca tattctttga tgtcataaag ccatgcctct tttaccggaa cgcccatttg 2891341 ctcacagtag gaatcccaga tggctccgaa aggatatgtt ttgaattcct ccatcagggc 2891401 cagcctttct gtatagcggc cctcttcctg caattgtttt aaatatccgt tcgggagaag 2891461 cagggcatac aataaagctt tgatcatatt tctcgttccg atggtccagg cggctacacg 2891521 gttaatgctg gcatcgaaaa aatccagacc gatggctacc ttctcaagag catgatttcg 2891581 tacaatttca agagcgattt ctctcaattc atcatccaaa accactacat ggtcgctatc 2891641 ccaacgaaca ggccgcgata cgtgcaaggc aagcttgtct gtgtaaagca gcatggacga 2891701 gatcttgttt gataccgtct cagtcggatg gaaatggcct gtatcaagta aacaaagctt 2891761 atgattcgtc aaagcataag ctaaataaaa ttcatgagat ccgacaacat atgattcgga 2891821 gccaagcccg aacagcttgc tctcgattga atcaagatta tgttgttcac tgatctcctc 2891881 tgagaagatc cgatccagtg attcttttag tcttttacgc ggtgtcagcc tatcactcgg 2891941 gatatcctta tagccgtcgg gaatccaaat attcgtcaag caaggtgttc ctaattcttt 2892001 cccgaagtat tccccgatac ggcggcaagc gatgcaatgc ctgatccaaa attctctgat 2892061 gtccggatca gggtgtgaaa gggtgagtcc gtcagccgct ttctcatgcg aaaacaaggt 2892121 tggattaaaa tctaaaccga gaccaaggtt ttttgcccat ttcacccagt tttcaaaatg 2892181 ctgcggcttc aattcgtcac gttctaccgc ttccctgttt gtttctgcgt atatcgcatg 2892241 caggtttacg cggtgctttc caggaatgag agaaagagcc ttctccaaat ctcttcttaa 2892301 ttcttcagga gtttgcgctt ttccgggata attgccggtc acgtcaattc cgcctgaaag 2892361 ctcgccctta tttacttcaa agccttcaat gtcgtcaccc tgccagcagt ggatcgaaat 2892421 gggcacttgc tctaattgcc gaagcgcctc ttcaacatca attccccatt tttcatatgc 2892481 ctgttttgca ctgtcataat tggcttttat ggtcatacgg ctctctccct ttatcagttt 2892541 ttcaatccaa ataaaaaact tcctttagat ctatcgcaac aggactgaaa tccgaatttg 2892601 ttttcattaa tggcgccatc gatttccacc atctttggca aacttccgtg tccgccatct 2892661 ttctccattt ctcttcatcc tctatttcta aatatgcaaa aagcctgcct gtttcctcgt 2892721 ctagaaaaat ggaataatgg tgtgctccat gagctttgag tgcttctgcc atctcaggcc 2892781 aaatgtcatc atgccgctgt ttgtattctt cgtacttgtc ttgatggaca aacatgatac 2892841 tggcttttct tttcaaacct tttcacctct tcatcattta gatagcgctt tcaaaacagt 2892901 ttgctgaaat gactgaatga tcgtgcttct atcaatgtct ttaggtgtaa acactttgat 2892961 cggaaaggaa tttctgacga cttgccgggc ttcttttatg tctttgactt ctttggcagc 2893021 aatcatttgc atcaaaagat ttccggtggc agttgcctct atcggccctg catataccgc 2893081 ttttccactc atgtctgccg ttaattgatt taagaaatca ttccgggctc cgccgccgat 2893141 gatatgaaat tgctcgatcg gtttttctgt gattgtttcg agctctttga tggctatcgc 2893201 atagatgatg gctaaattgc tgtagatgca gcaggcaagt tcgcctgcag tacggggaat 2893261 cttttggcgg gtttgtctgc aataatgttg tatttccttt atcatgtttt ctggattcag 2893321 gaaacgttta tcatttaagt ttataaattg ctggaatggt tctgtttttt tggcttcttc 2893381 tgcaagctgc tgaaaagaat aatctgcttg tagctgctgt ttgacttctt gtatcaccca 2893441 catgccgata atgtttttga gaaagcgaat ggtgttgttt gcgccgcgtt catttgtata 2893501 gttgttttct aaagcaagat cagttattat cggtgttttg ttttcaaccc cgattaacga 2893561 ccatgttccg ctgctgatat acgcccagcc atcatttacg cctggcgccg caatgacggc 2893621 cgaggccgta tcatgtgttg cgactgtcat caccttgcac gccgggagat cataatccgg 2893681 gaaccactca tttcttagct tcccgagttc acaccccggt tcagtgagcg gcgcaaattg 2893741 ctgttccaga acagacacgg cttcaagcaa ttcaggatca agatttcccg ttgagacgtt 2893801 taaaagctgt gttgtggaca cgtttgtgat ttccgttaca gcttttccgg ttaaacaata 2893861 gcctaaataa tcaggaatca tcataatttt gtctgtcttt ttcagcagct cacggtcttc 2893921 ttcaaacaat tgatagatcg tgttgaaagg ctgaaattgt attcctgttt tttgataaat 2893981 tgcggctttt gagagggtat gttccagttt gtctattgtg tgatctgttc ttctatcacg 2894041 gtaggagatt gcttcccgca accgatcgcc tttttcgtcc agtaagacat aatcgactgc 2894101 ccatgtatca atgcctacgg tgcagtgttc atacccaagc gtctttactt tttgcagtcc 2894161 ttgcaggatt tgttttagca aatgatcaat atcccataag caatgcccgt ctctttgact 2894221 gaaaccgtta gcgaacctgt gaatctcttg tatgtcaagc ttcccttcat tcagttcacc 2894281 taccatgatt ctcccgcttg atgcgcctac atcaatggca gtataaatca tcctttcacc 2894341 ctctcttcga aagaggaaca gctgtcacct tcaccttttt gtcctcaaga gcttttaccg 2894401 atgccggatc aagtccagaa tccgtaataa ggcggctgac atcttgcagc gaggcgatat 2894461 gtgaaaactc gcggttcccc catttgcttg aatcggccat caaaatggtc tggtccgacc 2894521 tttcgatcat ccgttttttg agcagcgcct gccactcatt tgaatcactc atcccgttgt 2894581 gtacgtcaaa tcccttacat gacagaaagg ttttattgac atgataggtc tcaagtgaac 2894641 gctctgctaa cgggccggca aatgataatg atttttccag caaaatgccg cctgttgaaa 2894701 tgactgatat gttttcttta ttgctgagtt caatagctgc tttcattgag tttgtaatca 2894761 cggtgagctc aatgtcaggg agtatttttg ccatgtacca agcggttgtg cttgcatcga 2894821 gaatgattcg gtctccgctt tttacatatt tggccgcttc gtgagcgatg gctttttttt 2894881 cgatgacatt cgtgatttcc cgttcagaaa aatgaatttc tgattccttc tgctgaatac 2894941 tgaccgctcc tccgtggctc cggctcagtt tatgttcttt ttcaagcttt tcaagatcac 2895001 gccgaatggt ttcctctgtg actgaaaaaa tgtcacttaa ttcggaaacg cggatgcttg 2895061 aacgcatatt tactatttcc actatttttt gctgccgttc tgctactagc atcggtaacg 2895121 cccttcctca tatcgtagtc cgtcttatat ttttatcata gcatatatct aacgcgtaaa 2895181 agcagcaggg acgccgccgt ctaccgtgat catgcagccc gttgtttttt cggctttgga 2895241 agaagcgaag aatgcaatgg cttcggcaat atcctccggg taaatattga cgagcaatgc 2895301 tgtccgtttc cggtaatgtt cctccagctg atccggttca atcccgtacg ccgcggctcg 2895361 ttcctcacgc cagcttgaac cccagattgc cgatccttga agaactgcat caggcaaaac 2895421 ggagttgacc ctaatgccga attctccgcc ttctgctgcg atgcatcttg ctaaatgggt 2895481 ttcaagcgcc ttaacagagc tgtaggcaga ggcgtttttt cccgcataaa ctgaattttt 2895541 cgatccgaca aataccatgc ttccgcctct attttgatgt ttcatctgtt taaacgcttc 2895601 acgggctaca aggaaatagc ctgttcctaa aacattcata ttaagattcc attcttttag 2895661 acttgtttcg tcaaatgggc ttgatgtggc cagcccggca ttattgacga cgatatcaat 2895721 gccgccgtaa gcaagcgccg ctcgttcaaa agctgactgt acgtcttcct cctttgtcac 2895781 atccattttg acagccattg cccgtccttt tccgtatgca tcgtttattt ccccggcaat 2895841 tttctgtgcg ccttctatat tcagatcagc tacgatcacg tgccctccct cagctgcaaa 2895901 tcggcggcat gccgcactgc cgattccgcc ggctcctcca gttatcagcg ctacttttcg 2895961 ggaaaattct gcttccggcg gggccagcgt gagtttatat agttcgagcg gccaatattc 2896021 gacatggtag gactcatttt catgtaaaga aacaaattgc cccagagcgg ttgctccttt 2896081 cattacggcg atggccctcc gatataaagc cccgcttact ttagacatcg cataactttt 2896141 tcctgtattc accattccga ttccaggaat caatatcacc cgcggggcgg attcaaagat 2896201 ttgatcccca tcctgctgat tgcgtgtaaa gtaagcctga tactctgatg taaaggtctc 2896261 gactcctgac ttgatcagat ctgcaagctt gtgcacatct tgagtttccg gattccaatc 2896321 aatgtacagc ggaacccgtt ttgtgtgaac aaggtgatcc gggcatgccg caccgatttg 2896381 cgaaagtgct ggcgcttgga cactgtttac aaattccaag acatcgtcat gatcatcata 2896441 ggaaaggatc attttctttt cttcacttac tgctcctctg atcacaggca tgatgcctgc 2896501 caagatttgt tttcttttat cctccggcag cggctgatac cttttgcctc cgaatacctc 2896561 atgctgattg atacgatcgt taatatactg ctcggcttct tgaatgatgg atatcgtttt 2896621 ttgataacat gtttcagacg tctctcccca agtgactaag ccgtgtttct ccattaatac 2896681 aagctcggcg tgggggttgt ttgctacgcc ttcagcgatc attttagaca aagtaaatcc 2896741 aggacggacg tatggcaccc atacaaaccg atttccgtaa atgtcttcag cgatttgttt 2896801 tccattatcc gcacagcata tgctgataat cgcatctgga tgggtatggt caacatgttt 2896861 gtatggcaga aaagcgtgta atagcgtttc aattgaaggg cggggatgtt tgctgtctat 2896921 catacaatga gacaggtagt ctaccatttc ttcatcgggc atttggtccc ttttaatcag 2896981 cgggcggata tcatctaatt tcaaaccgga aaagttatgc gctttcattg ttgccaaatc 2897041 cgatccgctt ccttttaccc acatgacttc tatttcacgg cctctaaaat ccttttccgt 2897101 tgttttcata gatgtattcc ccccgcccca gttgcagaca gtgcggtctg acccgatcag 2897161 attggacctg tacaccaatt cctctacacc tttaggtagc tgtgcagctc gctctgaatc 2897221 ccatatatgt ttcaccatat ttgatattcc tccataccct tttatttgta tccgttttca 2897281 ttatatatga tttctgtttg tttttgaatc gtttttgttt atttttgctt tttaacaaaa 2897341 aaagaaagca gcagatatgc cgctttctcg tttcattatg attctatttt aaatttcttc 2897401 gtaatgtcct gaagttcttc cgccatgttt gccaacgttt ccgctgaaga gctgatttct 2897461 tccatggacg caagctgttc ttccgccgaa gctgcgatat cctgaatgcc tgctgagctt 2897521 tctttcgcca ctgcagaaat atcttcaaca gcacttgaca cttcctgtga tccggctgac 2897581 agttgttcaa ccgtcgcgtt caagttttgc aattcgccgg aaatttgggt tgtcatctca 2897641 tagatttgtt taaagctttc cgctgtttga tccgtaatct gcaagccttc tttcacttca 2897701 tgattcacgg attggaacat tgaaagtgag gtgctgattt ccctgacaat ctcttgaatt 2897761 aatccttcaa tttccttggc ggagtctgct gattgtacag caagttttct aacctcttcc 2897821 gcaactactg agaaacctct tccgtattct cccgctcttg ccgcctcaat cgcagcattt 2897881 aatgcaagca ggttggtttg atcagcaatg ccgttaatca cattcaagat gcttgtgatg 2897941 tcttgcgatt ttgtttcaag gcccttcaca accgcttccg ctttttgaac ggattggtca 2898001 attgttttca tctggccgac tgtatgctcc accagctttt ctccgctgcc cgctgcctca 2898061 gaggactgaa tcgatgattt cgtaatggtt gaagaggctt gagccacttt tgaaatcccc 2898121 tcgttcattt gagaaagatg atttgagctt gtttccagtt tctcgctttg tgcctcgttg 2898181 ccatctgaga actgttcgat ggcaagtgta atatgttcag ttgccttgct tgtttgggct 2898241 gcgcttgctg tcagctcctc agaagatgaa gcgacgtttt ctacagacgt ttgaataacg 2898301 cctattacag aacgcaatga tgcagacatt tcattaaagc tttcgccaag ctggccaaac 2898361 tcgtttttcg agtgaatgtc aatgacttct gtgagatctc cgctgctgat ttttgcagac 2898421 gttgagacaa gttttcttaa cggcttggtg atggcacgga taatatagag tatgagtatg 2898481 ccgccgatta ctattgacac gcatagaatg ataaccgcag tgttcagcac cgggcttgaa 2898541 gcatcttgca attcactgac aaaatatgtg cccgcgattt tccagccagt cagtttattt 2898601 gtcgtaaagg ccattttctt ttctttgcct tcgaatgtat attcaaatga gccttctttt 2898661 ttggaatata cttggtttgt ccaatcgccg gaaccggttg tccccggctt aatggtcgga 2898721 tgggcgatat attttttgtt gcctgtcgta ataaatgcaa agccttcttt tccgattttg 2898781 attctttttg atgcagtaag cacttcatcc aggtttaaat ctagcgctat aacccctgaa 2898841 ccgtctttta attgttttga aattgtgaca acgatatctc ctgtcgcttc atcggtatac 2898901 ggttctgaga aaacagcttg tcctttttcc gcaaccgcct gtttgtacca gtcacgtcct 2898961 gtcggatcga aacctttcgg aacaccgcta tccggatatt tataaagctt cttatcttct 2899021 gaggcagcat agattgcgcc tacatcgtcg ttaagtgtcg tgtactgctt aaatttctct 2899081 ttcagtaatg ttttgttttt gcctaacaat atgtctttat cgactgtctc actataataa 2899141 tctattgctt ttactttatc ttctaattta ttttgcagcg tactgtttag ttcttcaaca 2899201 tttcccttcg cactgcttat gagctctctg tctaacgcgt tccaagctga ttgataactg 2899261 aaatatgcta aaaccccaac cggcaaaata agcactgcca gaaacgcagc gattagcggt 2899321 ttgctgatcg atggctgttt gatccattgt atgaattttc ccattctcgt tgactcctcc 2899381 tttaagataa atctaatatc gtcaaactag gataaaaggt ttaataaaaa aactaaaaaa 2899441 aacacccaag cgcaacaagc ttgggtgtta aggcttatta ttcaatttta aatcgtttgg 2899501 tcatatcccg aagctcttcc gccatagagg aaagggtctc tgcagacgag ctgatttctt 2899561 ccatggaagc tagctgctct tcagctgacg ccgcgatatc ttgtatatgc gctgagcttt 2899621 cttttgaaat cgatgcaatg tgctcagacg ctcccgaaac ttcttcggag ctggcagaaa 2899681 gctgctgaac cgtcgcactc atattttgca gttcgccggc gatttggttc gtcatttcag 2899741 aaatgcgttt gaagctcatt tctgttttat ctgtgatgtc aagtcctgtc tgcacctctt 2899801 gattgacaga ttggaacatg ccgagtgatg tattgatttc cttcacaatt tcgatgatta 2899861 atccttcaat ctcttttgct gaatctgctg actgtactgc cagttttctt acttcttccg 2899921 ctacaacgga gaagccgcgg ccgtactcgc ctgcgcgcgc tgcttcaatt gctgcgttta 2899981 aggcaagcag gttcgtctgg tctgcgatgc cgttgatcac acgcaaaatg tttgtaatat 2900041 ctttcgattt cgtttccaat ccgcgtacga cttgctccgc ttctttaacg gacttgtcaa 2900101 tgacattcat ttggccgacg gtttgatgaa caagcttgcc gccttcactt gcaatttctg 2900161 tcgattgaac agatgaatca gtgatcactt cagaagcttg agccatattc gtcaacccgt 2900221 cattcatttg ataaatgtgc tctgctgccg tttcaatgtt ttcgttttgt ttttcattgc 2900281 cgttagaaaa ttgttcaatc gccaatgtaa tgtgctctgt tgccttgctc gtttgcgcag 2900341 ctgatgcagt cagctcctca gaggaagcgg caacattgtc taccgaatcc tggatggcgt 2900401 gtatgagaga acgaagtgac gacgccatat tgttaaagct tttgccgagc tcgcccaatt 2900461 catcttttga acggatatca atggtttccg tcaaatctcc ctcgctgatc cgcttagagg 2900521 aaccgacaag ctgtttcagc ggtgttgtaa tcgaccgaat gatcaatgtc atgacgataa 2900581 tccctatgat aatagctgcg gccaagacaa ttaaagcaag gtgaaggaca ggctgggctg 2900641 cctcatggat ttcatccaaa tacatggtgc cgccgatctt ccatcccgtc aacttgtttg 2900701 tgtcaaaggc catttttttc ttatcgccat ccatggtgta ttgaaaatcg cctttatcag 2900761 cactcaacat cttatcgagc cagtcgcctt ttaattcagt tcctgattgt tcattagggt 2900821 gtgcgacaac ttttttgtcc ttcgtcatga taaatgcgta gccttgtgtg ccgatgttga 2900881 cttttttggt tgttttcagc agattttcaa tcgtcatgtt gattgcgata acgcctgaac 2900941 catcttttgt ctgctgggcg attgtcacaa ccatcgtatt tgtcgacgcg gttttataag 2901001 ggtctgtgat cacgactttc cctttatttg caaccgcttt tttgtaccag tcgcgttcaa 2901061 ccggattata gccgcttggc atcggaagat ccggatagcg ggtaaagtgc ccttttgtgt 2901121 cacttgtata aatggattct acatccttgt taatgctgat atattgtgag aatttctctg 2901181 caatgcttgc attgcttttt gcattgtatt tctcttttgt cagccattcg ctgaaataat 2901241 cagcactgtt ttctttttcg ccgatgctgg tgttaatgat ttcgtttaat tgctgtacat 2901301 tttccaatgc gctccccatc atctgtctgt cgagtgagct gctagccgat tgatacgcaa 2901361 agatcgccaa tatgacaacc ggtatgatga ggatcgacag aaaggaaacg agaagcttcc 2901421 gtgtaattga tctttgtttt atgagttgga gtattttttt catcattcat ttctcctttt 2901481 ttatgctacc cttcatatcg gctggaaatg ggtaaatata tacagcaaaa aagaagaaat 2901541 ttaacaaaag taactaattt cccataaata aatagtattt tagacctatt atttgtctac 2901601 tttaaattgt tttgtcagat cacggagttc ttcagacatt ctttcaagcg tcagtgcaga 2901661 tgaactaatc tcctccatgg atgccagctg ttcctcagct gaagcggcga tatcttggat 2901721 gccatccgag ctttccttag aaatggcagt gatatcattt gaagctgcgg aaatttcttg 2901781 agctcccgct gacagctcct caaccgtcgc attcatgttt tgcagctcgg aagcaatttg 2901841 attggtcatt tgcgatatat gtttgaagct ctgtttagtt tcatccgtca tgacaagccc 2901901 tgtttcaact tctttgttta cggactgaag cacgttcagt gatgtgtgaa tttcttttac 2901961 tatttcactg atcagcgatt caatttcttt tgctgagtca gccgactgta ccgcgagctt 2902021 tctcacttcc tcagcgacga ctgagaagcc ccggccgtat tcacccgctc tggcagcttc 2902081 aatggcggca tttaaagcca aaagattggt ttgatccgca atgccgttga tgacacgcaa 2902141 aatattcgtg atatcctttg atttgatctc cagccctttc accacttgtt ccgctgcttt 2902201 tacggaatgg tcaattgtgt tcatttggcc ggctgttttc tggacgagtg tctccccttt 2902261 gcttgacact tcggttgaat ctgcggatgt ttctgtaatc actgctgcag cccgcgccag 2902321 ctctgccaat ccgtcattca tttcattaat ttgttcggtt gtcgtttcta ttttctcgct 2902381 ttggctttca ctgccgtttg aaaattgctc gatagccatc gtaatgtgct cagtggctct 2902441 gcttgtctgg tctgccgatg cagtcagctc ttcagacgag gaggcaacgt gttctactga 2902501 gtctttgatc ccgtgaatga gcgagcgaag cgagtgtgcc atatgattga agctctcact 2902561 cagaacgccg agttcatctt ttgaattgat ttcaatcgtt tcggttagat cgccttcact 2902621 aattttttca gcggatgcga caatgcgtct caatggcttt gtgatggatc gaatcacaaa 2902681 ataaatcgcc gtcattccag ctccgatggc aatcgccaga acgattgaag ccatgatcag 2902741 aaccctgctt gcagcatcgt gaatctcgtt tgcatacatc gtgccgctga ttttccagcc 2902801 tgttgtttgg cttgttgcaa atgccatttt tttctttttg cctttgtacg tatattcaaa 2902861 gtccccgctt ttatccttgt agagcttatc aacccagtcc ccttttagct ctgttcccgc 2902921 tttttctccg gagtaggcga tgactttctt gttttggctc aaaataaaag catagccttc 2902981 ttttccgata ttgattcctt tcgcggtagt gactaagtca tcaattttca tatcaatggc 2903041 gacaacgcct gacccatcca ccgtttgacg ggcgatggtg acgaccattt ttcctgatga 2903101 aatcgattca taaggctcag tgacaattgt tttgccttta ttggccattg cttctttgta 2903161 ccaatctcgt tccaaagcat taaagtcgct tggcatgtca gcgtacggat aacgtgtgaa 2903221 gtccccgtct ttgccgcttg aaaataccgc agcgacatta tcattcattt ggataaattg 2903281 tttaaattcc tgtttcagct ctgttttctt tttatcctga aatttttctg ctgtagccca 2903341 atcgctgaaa tatgcgaggc ttttttcagt agtgctgatt ttatcatcaa tgatgtgatc 2903401 taatatctga acattttcct ttgcgctttg cgtcatctgt acatcaagtg aggcaactgc 2903461 tgattgataa gcgctaaccg aaagggcggt tatcggaaca attaagatca gcaggaaaga 2903521 aataataagt ctccttgcaa ttgatgatct gcgaatagtg gtgagtgttt ttttcatttc 2903581 cttttgaacc ttctttcaat aatttacaaa ttatatcggc ggatcttcct ttaaattaca 2903641 ttgaaaatgg aggaaaaaat gaaaaatagt tctaaattca cctgttaaac taggacttta 2903701 ttattgttta ccatataaaa aaacagcgct ttgatagcgc tgtttttcgg tttttactcg 2903761 attttaaatt gtttcgtcag atcgcgaagc tcttctgcca tctgcgcaag agtcgtcgct 2903821 gaggaactga tttcttccat ggaagcaagc tgttcttcag ctgatgcggc aatgtcctgg 2903881 atgcttgccg agctttcttt cgacacgtct gcaatgccgc tgactgctgc tgaaacatgc 2903941 tgtgaacggt ctgacagctg ctcgacggtg gaattcatcg tctgcagctt gcccgcgatt 2904001 tcgtttgtca tgctgaaaat gctctggaag ctttcttttg tattgtctgt gacaacaagt 2904061 ccggactgta cttcctgatt gacctcttta aacatgtgaa gagaggtgtc gatttctgcg 2904121 acgatttctt ggatcagctt ttcgatttct ttcgctgaat cggctgattg gacagccagc 2904181 ttgcgcacct cctccgctac gacagagaag ccgcgtcctg actctccggc acgcgccgct 2904241 tcaatggctg catttagtgc aagcagattt gtttggtcag cgattccgtt gatgactctc 2904301 aaaatgcttg tgatgtcttt tgattttcct tctaagcctt tgacaacagc ttcagcctgc 2904361 tgaacagatt gattaatcga gttcatttgt ccgactgtct gctgcacaaa cttctcaccc 2904421 gttccggcga tttccgttga ttggatagat gcctttgtaa tatctgacga tgtttgtgag 2904481 acttgctgga gtccttcatt cattaagttc agctgatgag agctggattc aaccttttcg 2904541 ctttgctcct cgtttccgtt tgagaactgc tcaatcgcca tcgtaatatg ctcggtggct 2904601 ttactcgtct gcccggcaga tgcggtaagc tgttcggaag atgcggccac attgttcacc 2904661 gagtcctgaa tagcgctgat cagagagcgg agagattgtc ccatttcatt gaagctttcc 2904721 ccaagctctc caagctcatc ctttgaatgg atttcgatcg tttcggtcag atcccccctg 2904781 ctgatcgttt tcgatgattg aacaagacgt tttaacggtt ttgtaatcga acgaacgata 2904841 aacagaatta aaattccgcc tgccacaatg gaagcaatca gcacaatcat tcctgttgtc 2904901 agcacagact ttgaggcatc cttaatttca tccatataca ttgtgccggc tattttccaa 2904961 ccagtcagtt cgtttgtagt ataggtcatc tttttatctt cgttattaag agtatactgg 2905021 agttcaccgc tgtcattcgc atacattttg gctacccagt cgcctgaaag cttttctcca 2905081 gccttatggt tcttgtgggc gacataggtt ttgttttttg ttgcaatgaa agcataacct 2905141 tcttttccga ccttgatttg tttcatttgt tctaacaatt tatcaatggt aatatccatg 2905201 gcgacaacgc cagatccgtc cttcagctcc tgtgcaatgg taatgaccat gcttccgtca 2905261 ctcgcagcca cgtaaggatc tgtcacgaca atttcaccgc cggccttcat cgcatcctgg 2905321 taccaaggcc gttgtctcgg gtcgtatcct tccggcaatt tttcttttgg cgcttgtaca 2905381 taagtgccgt tatctgcgcc cccataaatt ctggctactc cttgattaat agatacatat 2905441 tgtgaaaatt tagctttgat ctcttcttga tttgatttcc ctttgaatgc ggatctttta 2905501 agagattcac tgaaaaaggt gactgctttc gctttttctc ccagatcatt tgtaacagtt 2905561 gtattaaatg tatcgacact gtttttcgca tttcccataa tttcctgatc cagctttccg 2905621 ctggcgcttc ggtaagagct aaattctaat ataagaatag ggataatgag aatcgcaata 2905681 aatgagacga ttaatttctt tgaaatagac ggtttcttca gccaattgat aaaagtcttc 2905741 atgtcacttg ctccttcagg tttgatacag tatatatcgg ctgcttaaaa aagttttaaa 2905801 ataaaaaatg gaagaagttc tttttggctg tcttctgcct ttttaacttt cattgcccaa 2905861 gctctttgca tatcttataa aaaacaaggg gggctaaaca tgattattgt atcaggacaa 2905921 ttgctccgtc cccaggatat tgaaaattgg cagattgatc aagatctgaa tccgctctta 2905981 aaagagatga ttgagacgcc tgttcagttt gattatcatt caattgctga actgatgttt 2906041 gagcttaaac tgcggatgaa tattgtagca gcggcaaaga cgctgcacaa aagcggggcg 2906101 aagtttgcca cttttttaaa aacatacggg aatacaacgt attggagggt ttcaccggag 2906161 ggcgccttgg agctgaaata cagaatgccg ccttcaaaag cgattcggga cattgcagag 2906221 aacggcccgt tttatgcgtt tgaatgcgca accgcaatcg ttatcattta ttacttggcc 2906281 ttaatcgata caatcggaga agataaattc aatgccagct ttgacagaat tattttatat 2906341 gactggcatt atgagaaatt gccgatatat acggaaacag gacaccactt tttccttgga 2906401 gattgtttgt attttaagaa tcctgaattt gatccgcaaa aggcgcaatg gagaggcgaa 2906461 aatgtgatac tactggggga agataaatat tttgcccatg gtcttggaat cttaaacgga 2906521 aagcaaatta ttgataagct gaattctttt aggaaaaaag gagccttaca gtcagcctac 2906581 cttctgtctc aggcgaccag actggatgtt ccgtctcttt tccgcatcgt ccgctaaaaa 2906641 gccccatcgc ctattttccg gacgatgggg tttcaaatgc ctttcgtttt cgatagaagg 2906701 gggctgtgcc aaaatattgg ttcgcagccc actccatttt ttcaaggtca tttcttgtca 2906761 cgattggatc ctggctgctc catttgataa agcggacaaa atagtagcct ttgataggaa 2906821 ccattgtaac ttttgagtga ggccagcctt caaatacaaa ctcaattttc cctctttttt 2906881 tataagaata ttgaagaatg ttcatatctg tcacctcagt ttatcaagtt acgttcggca 2906941 aagctcggta cgtttacatc cattgattaa ctatccctca tgcaggcttt ccggaaaaca 2907001 aagggtgagg cgcgtgtctc tttccctcgc tttttatttc gcatatggac gaatgccaag 2907061 cacgccttca ttcgataaag ccgcagcgtg ggcgggtgtg acaagccctc cggctatcgg 2907121 cgcttgttca gcgatcatgc ttttgtcata aaaaacagcc tattatccca tcattttgat 2907181 atagcatgtc cgggtgcgag gcccgtcaaa ttcgcagaaa taaatgccct gccacgttcc 2907241 aagaataagc cggccgtttt ccacaatgac atgctgtgaa gctccgaccg tactcgactt 2907301 catgtgtgca gctgtattgc cctccatatg gcggtccagc tcatgttccc acggatatac 2907361 ctcatcaaac cttctgagca tatctttttt gacgtccgga tcggcatttt cattaattgt 2907421 aatgcccgca gtcgtatgcg gacagtaaat cagcgctgcg ccgctcgtta tacctgtttc 2907481 ttgaagaaac gcttccacct cccgggtgat atctatcatt tcatctcgtt tggttgtttt 2907541 gatttgcagt gttttcagca tttgtttctc ctttcgtttg tccgctctca tcgcttaatt 2907601 cgttctgtgt tctttttttt cctgttaaac cgctctcata aacccgataa aacaaaaaaa 2907661 ctccagtcta aggctggagt ttagcaccat agatatattc ttgcttcata cggctttaag 2907721 agtactgatg tcatatgctt gtgcggctct gtttcaatat ttgacaagac gagtgcatct 2907781 gatgacaatg gcaatccaga gtgcctgaac aacgccggtg ttcctgtcag attggccgca 2907841 atcagtgcag tatggctctc gtttttccga agatatgcaa agatttgctg atcttccggt 2907901 aaaatgagct cgtatgtccc gttaataaaa acatcatatg tttggcgcag cttgatcaag 2907961 cttttgtaaa aatggtaaac ggatgtttta tcgttttttt gcgcctcggc attcagccat 2908021 ttgtaattct cattgattcc gatccacggt ttggcctcag aaaatccggc gtatggacca 2908081 gcattccatt gcatcggcgt tcgcgaattg tctcttccct ttttccagac aatcttcatc 2908141 acatcctcgt gtgatgtgcc tttcgctgtt tttgtttcat acaggcgttt caatgcgaca 2908201 tcatcatagt cctcaataga tggaaaagcc acgttcgtca tcccgagttc ctgtccctga 2908261 taaataaacg gtgtgccttt catgagaaaa taaacagcgg aaagcgcttt tgcactttct 2908321 ttcaggtaca ctccgtcgtc tccccacaca gaaactgaac ggggctggtc gtgattctcc 2908381 ataaacaaag cattccagcc gatcccttcc agactgtcct gccagtcagt taaaattcgt 2908441 ttaaatgcaa cgatatcaat actttcattg atctctacat cccacaggcc gagatgctca 2908501 aattgaaaaa tcatgctgaa tatgccgttt ttttctccag cccaatcagc tgcttctttt 2908561 gcagcgacgc cgtttgcttc accaactgtc ataatcggat agcgggaaaa tgtgttttcc 2908621 ttcagctctg ttaacaaatc cataatgccg tcagcattca tatgataagg aaaggaaggg 2908681 acatagtcca gtccctttgg attcggcatg tcaggaaacc cttctttttt cttaatatgc 2908741 gtaatggcat ccacccgaaa tccgtcaatt cctttatcaa gccaccaatt gatcatgtca 2908801 taaacggcat tcctcacctt ttcattttcc caattcaaat caggctgttt tttatcaaaa 2908861 aggtgcagat aatactggct tgtcttttga tcatactccc aagccggccc gccgaaaatg 2908921 ctttcccaat tgttgggcgt ttttccgttt ttgccgtctt tccaaatata ccagtcgcgc 2908981 ttttccgagt gtatggatga acgggattct atgaaccatg gatgttcgtc gcttgtgtgg 2909041 ttcacaacga gatccataat cagcttcata tccagatcat gaatgtcacc aagcagctca 2909101 tcaaaatctt ccatcgtgcc aaactcgctt aatatgtttt gataatccct gatatcatag 2909161 ccattatcgg cattcggtga atcatacagc gggcaaatcc atatgacgtc agcgcccagc 2909221 tcttttatgt aagaaagctt ggttctgatt ccttgaatat ccccgattcc gtcgccattt 2909281 gaatctttaa aactgcgggg gtaaatttgg taaactacgg cttccttcca ccaagccttt 2909341 ttcatacagc cactccttcc cagtgtaccg ttcttatata tcctatgtag aaaaaggtct 2909401 ttacagcatt gctttttaag aaatgacttg atgacacaaa aaacagccgt ttgttccccg 2909461 gctgtttttt atcaaaaatc agtttttttt atttctacaa aacggatgtg gtgatcttcg 2909521 gcgtcgagga ttttaaattc acagccctcc gcgtgtatca catcccctgc tttcagctcc 2909581 attttttgcg ttagaagcca gcctgcaatc gtatcaattt cttcattttc aatcgcaatg 2909641 tcgagaaggt cattcacttc gtctattagc gcttttccat ccatcacata atggtgctcg 2909701 ccctttttca ggatgtgcgg tgtttcatcc tgatcatact catcgcggat ttccccgacg 2909761 atttcctcga taatatcctc tacagtgaca agccccgccg ttcccccgta ttcatcgaca 2909821 agaatcgcca tgtgaatccg ctccttctgc atgcggatta aaagctgctg aacaggaatg 2909881 ctttcaatga ctctgataac gggcctcatg atttgattca gctttatcgg ctggccgaga 2909941 aaataagctt taaacatatc tttgctgttg atgatcccta aaatatgatc cttgtcatct 2910001 ttgatgacag ggtagcgtgt ataccgttca ttaatgatgt gatgaattgc ctcttcaagc 2910061 gactgctcca gagagataac cgcaatttct gtccgcggaa tcataatctc tctcgctacc 2910121 cggttgtcaa attcaaaaat cttatttaca tagcggaatt cagactgatt gatttctccc 2910181 ttttcatagc tttcagaaag gatcagcctt agttcctctt cgctgatgac aacctgatgc 2910241 tcctttaccg aatgaaagcc aaacaatttc acaagaaaac ttgcagagcc gtttaatgct 2910301 ttaataaacg ggtacgtgat tttataaaac cagatcagcg gctttgcaat ccataagctt 2910361 acagcttcag ctttttgaat agaaaccgtt ttcggggcaa gctcccccat caccacatgc 2910421 aaaaaagtga cgatgataaa tgcaactaca aatgtgacaa tgtggttaaa cggttccggt 2910481 atgcctgtca ttgtaaataa gggatgaaga aaacgttcaa atgtaggttc accaagccac 2910541 ccaaggccga gggctgtaat cgtaatcccg agctggcagg ctgataaata ctcgtcaaga 2910601 ttggagatga ttttatgtgc ggctagtgct cggctgtcac cgctttcgat gagctgattg 2910661 atttttgaac ctctgatttt gacgatcgca aattccgctg caacgaaaac agccgtaatg 2910721 ccaatcaaaa caaaaatggc gatcaattgt aaaataagca aaaaaagccc ttaccataaa 2910781 tggtaagggg ccacctcctt aacgttaatt ctcatcacga ccgtttaaga aaatcatcac 2910841 aaaacgaagt agttcaaaca gggaaaccag ggcggcggcc acatacgtta aggcagcagc 2910901 actcagcact ttatttaccc cattttcttc attgtttcgg atgaatcctt ctgacacaat 2910961 aatctgcttc gcacgtgaac ttgcattgaa ttcgacaggc aatgtaatca gctggaaaaa 2911021 gacagccgct gaaaacagta tgatgccaag cccgatcaaa ttcaggctgc cgagaagcat 2911081 gcctcctaag aaaagcaaag gagctacacc ggatgcaaaa ttcacgactg ggaagatttt 2911141 atgtctcagc acaagcgcac catatgactc ctgatgctgc aaggcatgtc cgacttcatg 2911201 ggaagctacg gatatggcgg aaattgagcg gccgtaatag accggctcag ataaacgcac 2911261 cacccgtctt gtcgggtcgt aatggtctgt taaagtgcct cttaccggtt cgaccggcac 2911321 gtcgtaaaga ccgtttatat ctaaaatccg tcttgccgtt tctgcccctg tacgtccgct 2911381 tgaggcttcc acttttgaat atttttcaaa gttgctcttt actttaaatt gtgcccaaaa 2911441 cgacaatccc aatgcggcta ttgttaaaaa tataaacagc attttttcat catcctttgt 2911501 tcatgatcat ttctctatta cgattatttt aatgagtttt ctttctcgtg tacagaaatg 2911561 cgctttttct tccggcttgg agcacacaat ccaatcagca aaaagaacag gcctgctgaa 2911621 aacaaataaa aggcgaaact gccggccagt tctttcagaa aatgaagcca ggagaagctt 2911681 ccggaaaagt gattatatga attcaaatcg aaaataaaca aaatcaccgc ggatgccgcc 2911741 agctgcgtac cgattaaaac cacgatcgtt ctttgaaaga tcgtcatctt tttcatcctt 2911801 tttgttttag tttatggaga aatccggttt tatatgtttt gtacattttt tgaaaaacat 2911861 caccggaagt gggacatact gttagaaaaa agcacgggtg tgatggaagc tatgaaagtg 2911921 acgagtgagg aaaaggaaca gctgagcaca gcaatcgacc gaatgaatga aggactggac 2911981 gcgtttatcc agctgtataa tgaatcggaa attgatgaac cgcttattca gcttgatgat 2912041 gatacagccg agttaatgaa gcaggcccga gatatgtacg gccaggaaaa gctaaatgag 2912101 aaattaaata caattattaa acagatttta tccatctcag tatctgaaga aggagaaaaa 2912161 gaatgaaatc aaatcggata tttatttcat ggctcaggtg gccgttattt atccgaatcg 2912221 gggttattat tttatgtctg attcttttgt tcggccaaat catttatata cttgagccta 2912281 agcagttcac ttcggtattc gaaggtattt ggtgggctgt cgttacggtt tctacagtcg 2912341 gttatggaga ctatgtgccg cacactccgc tgggacaggc agccggaata ctgctgattt 2912401 tgagcggagc aagctttgtc acagcgtatt tcgctacgtt atcagcggcc gcattcagca 2912461 gacagcatcg ctacattgaa ggaaaagttg cttacaaagg ccgggaccac atcattctga 2912521 tcgggtggaa tgaaaaaaca aaccggcttt tgaaggacct tcagcttgcc gccccttcca 2912581 aaacagtcgt actaatcgat gaatccttaa cagaaggccc gcttattgaa aacgttcatt 2912641 tcatacgcgg gcacgctgcc gatgatggga cactgaaacg ggccaatatt actgaagcgg 2912701 aatcagtgat gattactgcc gatcagtata aaagtgaaac tgatgctgat atgctgtcag 2912761 tgctgactct tttatctgtt aaaggtctta atccccttgc ttactgcatc gtcgagattt 2912821 taactgaccg ttttgtcacc aatgcggaac gggcaggcgc aaaccaaatc atcggaactt 2912881 cagaatttat cagccgggcg atgctgcagc attaccaagt caagttacgg ccgtctaaac 2912941 agcagaacgg aatcaagctg acacttgatc agcatgtgga gcttcttgct gttcctgacg 2913001 aactaaaggg agcggcttac aaaacctgtg ttctctattt ccttgatcac aacacaacaa 2913061 ttataggcat acaaaaaaag gaggggccga tgctttcccc tcctcttaca tacaaggtgc 2913121 tcgaaacaga tcaattcctt gccatctagt gtaacagaac atcctccaat tctttcacga 2913181 gagaggcgcc gatatccaaa aatgccggat caatttccgc gtcccgcctt tccggttcgg 2913241 aaaattgatt aaacagtgat tggaaaggcc ctccctcggc gtgatcgtca acatccgcct 2913301 gaaacacctg tctcagcata aatggcgttc cgatccggac ggccgcccct cgttcatcga 2913361 gactgccctg taccgcattg acgggaattc ttaaaaataa atagccgtct ctatcatcaa 2913421 ttttataatc aaagtagcca tgatcgtatt cccagccgcc gtttatcaca taaccgagcg 2913481 gcttcatcac ttgttccagt tcttgaagca gaaaagactg cccatctatc gcggaaggta 2913541 ttggtatcat cagaatgccc cttttttcac ttatcctgtc ccgccgaaca agacttcatt 2913601 cagaggcgcc tacatggaaa tcgttgtttc tttcgcgcgg ccaacaggaa agaaagcgca 2913661 ttcaattaag aagtaaacag ccattgccgc tgcaagccat acagctgaat cccaagacac 2913721 ataaacaacc gttgcataga gtcctaattt agtgaaaaga gtatgggttc gttttaaatg 2913781 caaaatccga tgtaccgcat cggtaaaaag ggcaagcggc aaaccaatga gaagaaagga 2913841 gtggatgaaa aaatgtgaca gcgtgccgcc aaagcttgaa gaaaaccctg tatacacggc 2913901 atcaaaggag ataaggaaac ttaaaatagc tgcagaaaaa ccggcaatga tgagatgttt 2913961 aaccaattgt ttcatgaaca tcagcacctt tctgatttta taaaaagccg accggcaaat 2914021 gccagtcagc tttctcacat taatcttcca gacgtttttc aagctctgct tttttctctt 2914081 caaagccagg tttgccgagt aacgcaaaca tattgacttt atacgcttct acaccaggct 2914141 ggtcaaacgg attgacgcca aggaggtaac cgctcatcgc gcaggctttt tcgaagaaat 2914201 atacaaggta tccaaaagta tatgcattca gctcaggaat gttaacgatt aagttcggaa 2914261 catttccgtc tgtatgggca agcattgtac cttggaatgc ttttttgtta acgaaatcaa 2914321 cagttttacc ggctaaatag ttcaagccgt caagatcgtt atccgcttcc tcaattgtca 2914381 gttcatgttt aggcttctct acgttcagga ccgtttcgaa taaatctctg cggccttctt 2914441 gtacatactg gcctaaagaa tgaaggtctg ttgaatagtt cgctgaagaa ggataaatgc 2914501 ccttctcatc tttcccttcg ctttctccga acagctgctt ccaccattcc gcaaagtatt 2914561 gaagcgccgg ttcgtagttg atgagcattt caattgtttt gcccttatta taaaggacat 2914621 tgcgaacaac cgcatattgg tatgctgggt tatcttccag ttcagatgtt gcaaaatctt 2914681 tgctcgcatc cagggcgcct ttcatcatgt cgtcaatgtt gacgccgctg acagcaatcg 2914741 gcaagagacc tacagctgtt aaaactgaat aacggccgcc gacatcgtca ggaattacga 2914801 atgattcaaa gccttcttcg ttagaaagcg tttttaatgc gccgcgctct ttatcagttg 2914861 ttgcataaat ccgcgctttc gcttcttctt taccgtattt ctcttcaaga agcttgcgga 2914921 aaatacggaa agcgattgca ggttcagttg tcgtacctga tttagaaatc acattaatag 2914981 agaagtcaac atcttcaaga agatccatga cgtctctcat ataagatgaa ctgatgttgt 2915041 tcccgataaa aatgacttgc ggattgccgc gttttgcttt tggcaaagtg ttataaaacg 2915101 cgtgattcag cgcttcaatc gctgcccgcg ctccaagata agaaccgccg atgccgacaa 2915161 caagcaagac atcagagtca gatttgattt tttccgcgct ttttttgatg cgcgcgaatt 2915221 cttctttatc ataatgttca gggaggtcca cccagcctag aaaatcgctg cccgcgcctg 2915281 ttttctcatg gatattatgg tgtgctgttt ttacaaagtc ccgcaggtat gtaagttcat 2915341 gttcgttgaa gaaagtcaac gcttttgagt agtcaaagcg tacatgcgtc attgcttgtc 2915401 cctccataac ggtataatgt tttcatcttt cactttatat gaacttatct gtgaaatcaa 2915461 gtcaagaaga aagggcggaa tgactggatt ccgccctttg ggtttataga gacgcgcgaa 2915521 ggatggcaag cacgtcatct ttgttcagtt tttggaagtt gccgaagccg ccgtgttcca 2915581 tttccttggc tgcgatatca gcaatcagct caagcttttc ttctccaata ttgtaatcag 2915641 caagacgaga aggtgcaccg aggcttgtcc agaacgcaga cagtttatcg attccttcaa 2915701 gcgcaatttc tttatctgtt ttgccttcag tatcaatgtc aaacatgttg agcataaggt 2915761 ttttaaaacg gcctacattt gtatcaagcg tgtatctcat ccaatttggg aacagtattg 2915821 ccaaaccgcc cgcgtgcgga atatcatata cagctgaaac agcgtgttcc attgtatgag 2915881 aagcccagtc accgaagtat cccatttgga gcgtgccgtt taaagcaata gtaccagcat 2915941 acaaaatcgt ttcacgaagt tcgtagtttt ccagatcttc aagaagctta ggagctgttt 2916001 cgatgaccgt ctgcaaaaca gcaaagcaca ttctatcctg aagcggcgtg ttttcaacat 2916061 tatggaagta ttgttcgaat acgtggctca tcatgtcaac catgccgtat actgtttgat 2916121 tttctggaac ggtgaacgta ttttcagggt ctaaaataga gaaacgcgga tgagtgacat 2916181 tgctgcccca tacaaatttc tcgtttgttt cccagtttgt aatcacggaa tcagggttca 2916241 tttcagaccc tgttgcagca agagttaaaa cagtgccaaa cggcagcgca tcctccgctg 2916301 ttactttttt gctgaaaata tcccaagcgt caccgtcata tttgacgcca gctgcgattg 2916361 cctttgtaca gtcaatcaca ctgcctccgc cgacagcaag cagaaaatca atgtcatgct 2916421 ctctgcaaag tcctatgcct ttttccactg tcgcaagacg cgggtttggc tctacacctg 2916481 acagctcatg aacaacagcg ccctcttctt ttaaaatgcc tgtgacttga tcataaaggc 2916541 cgttgcgttt aatgctgccg cccccgtaaa caagcagtac attcttgccg tatcgtttga 2916601 attcttttct taattgttca agctgacctt ttccaaaaat cagctttgtc ggattataat 2916661 aagtgaaatt ttccatagta aaacctccaa atgatgctgg taaaaaacag attttccatt 2916721 gtaacataag ttgacaaaaa agaaaaaggg aagcagccaa acggctattt cccctttttt 2916781 tatagtgatg ctttcaaaat tgacagcaca tcttctttgt tgagtgattt aaattggccg 2916841 aatgtaccgt tagccattgc cttgtcagcg attgtgtcaa gctgctcatc attaatatca 2916901 taatcagcaa gacggttcgg agcgccaaga cttgtccaga atgcggacag cttatcgata 2916961 ccttcaaggg caatttcttc atccgtttta cctgcttctt caacatcaaa cacgcgaact 2917021 gcaagctgtt tcatgcgggc agggttttca gacaatgtgt gtctcatcca attcgggaac 2917081 agaatcgcca gtccgccggc atgcggaata tcataaacgg ctgatactgc atgttcaata 2917141 ttatgagtag cccaatcccc tcttgccccc atagaaagca tgccgtttaa tgcgattgtt 2917201 cctgtgtaca ggatcgtctc acgcaattcg taattttcga gatcattgat cagcttaggc 2917261 gctgtttcaa tgactgtacg caaaagtgat tcacacatgc ggtcctgata cggcgtgttt 2917321 gatacatgat ggaagtattg ttcgaatacg tggctcatca tgtcaaccat cccgtagatc 2917381 gtgtggtttt taggtacggt gaatgtattc accggatcaa gaatcgagaa tttagggaat 2917441 acgagcgggc tgccccagcc gtatttttct tttgtttccc agtttgtaat aacagatcct 2917501 gagttcattt ctgaaccagt tgcagcgaga gtcaataccg ttccgaatgg caaagcatct 2917561 tttggctgat gctttttcgt aacgatatcc cacgcatcac catcatactt cgctcctgcg 2917621 gcaatcgctt ttgtacagtc gattacgctt ccgcctccga cagccagcaa gaaatcaatg 2917681 ttttgttctt tacagatggc aacaccttta ttaacagtcg acacacgagg attcggttcc 2917741 acacctgcta attcatgcac ggtcgctccg gctttattca gctgttcaat cacttgatca 2917801 tacaggccgc tgcgtttaat gctgccgcct ccgtacacaa gcaatacgtt ttttccgtaa 2917861 ggtttgagtt cctccggaag tctttccact tcgccgcgcc cgaaaattaa tttggtcgga 2917921 ttccagtatg taaagttttg catgacatct cctccttaga ttttttatta tgcagaatgt 2917981 cctcaccaca tgtaaagcaa tcagctctca ccgatcagca taccagatgg ttttattttg 2918041 caaggtgctg ggaaagaagc tgatataagc gagggcaggc cagcttccct catatggaga 2918101 atgcatgtat agattctcca atatgtcaca atctataact gttttaataa ttcatggagg 2918161 aggttgcaaa acatgagtac cattcaaaga atttgtcttg tattaaccat cattggcgcc 2918221 attaactggg gactgatcgg atttttccaa tttgacttag tagcggctat cttcggcggc 2918281 caagggtcag ctctttcccg aatcatttac ggacttgtcg gaatcgccgg cttaatcaac 2918341 ctcggtctgc tatttaagcc aaacgaggaa agatcacgtg aagaagcagc aaatcctgaa 2918401 atgcgatagg atatcaatca cgctgaaata ggattttgca tgaaatcaaa agcaccgaac 2918461 attcctgtcc ggtgcttttt tcatgcttat tttttgataa ggtctttgcg gttggacatt 2918521 tcgatccact cttcaagctt atcttttaat gtgttgaaac cttgtggtgt agaagcttct 2918581 tcgcttactt gagcagcttt aggttttctt ggtttgcttt cttttttctc aggcgcagct 2918641 tgtgtcgcac gaattgaaag gctgattttg cctttttctt catcaacagc aagtactttt 2918701 acttgtactt cgtcgccaac tgaaaggtgc tcgttgatat cttttacgaa accgtgagtc 2918761 acttcagaaa tgtgtactaa accttgagtt tcttcatcta atgcaacaaa cgcaccatac 2918821 gcttgtaatc ctgtaacttt accagtgtaa acactgccca cttcaaattt tgctgccatt 2918881 cataacaact cctaagttaa attaaatatc tgtttatacg caatttaaaa ttatatcaca 2918941 catgtcttat ttccgcaaag aaaacttttt tataaaaaat caggtttatg cacagcaaaa 2919001 agggggtaaa ctgaaaatac caaaggcttt ctagtattcc ccccttttat tggatgcgaa 2919061 caaaaggttc gtatcttttt ttatgttgtt ttgtgcagga agcgtttcat tctgactaac 2919121 gcttcttgaa gctgttcaat cgaggttgcg tatgaacaac ggatatatcc ctcaccgctc 2919181 ggaccaaaca cacttccagg aacaactgcc actttttcct gcgtcagtag ctcctcggca 2919241 aactgttctg aactcattcc catgcttttg atagatggaa aagcatagaa agcgccgccc 2919301 ggatgatgac agctgagacc gatttcattg agcgattcta caaacagatt ccgtcttctt 2919361 cgatagcttt ttttcatttt ttctacgtct tccatgccgt tcttcaggcc ttcaagggcg 2919421 gcaaactgcg ccattgcggg cgcgcacatc atcgcatact gatgaatttt aagcatggca 2919481 tcccgaagca aggatggtgc cgcggcaaaa ccgagcctcc agcccgtcat tgcaaatgct 2919541 tttgaaaagc ctgagatgac taccgtccgt tccttcattc ccggtaatgc cgctatactt 2919601 gtaaattcct catcatatgt cagctccgcg tagatctcgt cggctaagac gatgacatca 2919661 tgttttttgg caaactcagc aatctcattc agctcttcct tcgaataaac cgaacctgtc 2919721 ggattcgatg gtgagcagat gagaatggcc tttgtttttt cagtgactgc cgcttcaaaa 2919781 tcagcagccg ttgctttaaa tcctttgtct gccgttgtat gaacgtgaac cgggataccg 2919841 cctgccaaag aaacaagcgc atcgtacgca acaaaacacg gctcaggaat gatgacttcc 2919901 tcacctggat tcacaatggc gcggatcgca atatccaaag cctgacttgc ccccactgtc 2919961 acaatcagct cattatctgg cgagtagcta aggtcaaacc tgttgctcaa ataacggctg 2920021 atttcctccc gcaatgagta taaacccgca ttggccgtgt atgacgtata tccttgttca 2920081 agagagagaa tgcttgcttc gcggacattc catgcggtaa caaaatcagg ctcgccgacg 2920141 cctaaagaaa tgacgccttc catcgttgcc gccaaatcaa agaatttgcg gatgccggat 2920201 ggttttattt gttgtacata gtctgataaa tacgaagtca tttacggtga caccacgatt 2920261 cttttgtcgt cgtctcctgt ttcaaacact ttgccgtcat gcttgtattt tttcaggata 2920321 aaatgggttg tcgtagatac aactgaatca agcgttgaga gtttatccga aacaaaacgc 2920381 gctacgtcag acatcgaatt gccgcgaatc acgacagaca aatcgtatac gcctgacatc 2920441 aggtaaactg attcaacctc ttggaatcgg taaatccgtt ccgccacttc atcaaaaccg 2920501 acgccccgct tcggcgttac tttgacgtca atcatggccg taacgccctc atgtccgtcg 2920561 acttttcgcc agtcaatcat agcggaataa tcgataataa ccttttcttt ctccagtttg 2920621 tcaataattg ttttcacttc atttacaggg atgcccgcca tctttgcgat tgtttctaaa 2920681 tcggcgcggc tgttttcgtc taaaatttct aatatttctg tttctttttc tgtcaatttc 2920741 atttgattca cacctttgca atgtcaagaa atctcatgac attatatcac gttttttgac 2920801 gaatgctaag aaaaaacgag gagaaacttc cgctagaatt gacaatttca gggcataata 2920861 caaccatcaa aaaaagggag tgacacagaa tggaggcggt ttcaccaata aggcggttta 2920921 cggtcgatgg agtcaatgta tactacgaac attatcaaaa tcccggcagg caaacgctgg 2920981 tctgcgtaca cggtttttta tcatctgcat tcagcttcag aaaagtaatt cctctccttc 2921041 gggacaagta cgacatcatc gcgcttgatt tgcctccttt cggccaatct gaaaaatcaa 2921101 gaacgtttat ctatacctat caaaaccttg ctaagcttgt cattgggatt ttggagcact 2921161 tgcaagtgaa acaggctgtg cttgtcgggc attctatggg cgggcagata tcgctgtctg 2921221 ctgctctcca aaaacctgag cttttttcaa aggttgtgct gctttgcagt tcagggtatt 2921281 taaaacgttc acacccgacg attattttcg ggacccatat cccgtatttt catctttaca 2921341 tcaaacgctg gctctcgaaa gaaggcgtga tgaaaaattt attaaatgtg gtgcatgaca 2921401 aatcgctgat tgatgaggag atgattgacg gctatggcag accgtttcag gacgagcaga 2921461 ttttcaaagc catgacaagg tttatccgcc acagagaagg agatttagaa cccgagcaat 2921521 tgaagaaaat gaacaagcct gctctattga tttggggcga ggaggatcga attgtcccaa 2921581 tggagatcgg taaacggctg cacgcagatt tgcctaattc cgtgctgtac tcacttggcc 2921641 agaccggaca tctggtgcct gaagaacggc ctgaacttat ttctgaacac attgctgatt 2921701 ttatcaaata acaaaaaaac cggtgctgaa ccggtttttt taaggcgtgc aggagctgct 2921761 gtttttaatg aataaaagct ggccagccac ttcccggcag ctggcgatcg gcagcgtttg 2921821 ttcaaaagaa gtttcaaata tttgctgaat gcttttcgcc agcaagtcgg gatcgttttc 2921881 atcatagact gcctgcacga catcaacagc ctccgtttcg taaaactctt ctccatattt 2921941 aaacgggtcc catttggcaa tgatcttaat catttccctg accgcatgac tttcttccat 2922001 attcatcacc gcttataata aaatttgcag ttctatctta tcatagtgaa gcttagaaga 2922061 ataaacatac atgagggggt aacagaatga actttgataa acgagaagaa cgccttggca 2922121 cccaatcggt caaatgggat aaaacaggcg aattatttgg cgtgacagac gccctcccga 2922181 tgtgggtggc agatatggat tttcgcgccc cggaagcgat aactgaagcg ttaaaagagc 2922241 gtcttgacca cggtattttt ggttatacaa ctccagatca aaaaacgaag gatgctgtgt 2922301 gcggatggat gcaaaacagg cacggctgga aggtaaatcc ggaaagcatc acattcagcc 2922361 ccggcgttgt aacagctttg agcatggcgg tacaagcttt tacggagccg ggcgatcaag 2922421 tagttgttca gcctccagtt tatacgcctt tttaccatat ggtggagaaa aacggccggc 2922481 acattttaca taatccgctg ctagaaaaag acggcgcata tgcaatcgat tttgaagatt 2922541 tggagacaaa gcttagtgac ccaagcgtta cattgtttat tttatgcaat cctcataacc 2922601 cttctgggcg ttcatggagc cgggaagatt tactgaagct aggcgaattg tgccttgagc 2922661 atggcgtcac agttgtatcg gatgaaatcc attccgattt aatgctgtac ggacataaac 2922721 acacgccgtt cgcttcgctc tctgacgatt tcgctgatat ttccgtgaca tgtgctgctc 2922781 caagcaaaac atttaatatc gccggattgc aggcttcagc gatcattatt ccggatcgcc 2922841 tgaagcgcgc caagttttcc gcaagccttc agcgaaatgg tttaggcgga ctgaacgcgt 2922901 ttgccgtcac tgcaatcgaa gccgcgtatt caaaaggcgg accgtggctt gatgaattga 2922961 tcacttacat tgagaaaaac atgaacgaag cggaagcctt tttgagcacc gagctgccaa 2923021 aggtcaaaat gatgaagccg gatgcatcat acttgatttg gctcgacttc agcgcttacg 2923081 gcttgtccga tgcagagctt cagcaaagaa tgctaaaaaa aggaaaagtt attttagagc 2923141 ccgggacgaa atacgggcct ggcggagaag gatttatgcg cctgaacgcc ggatgctctc 2923201 ttgcaaccct gcaggacggc ctgcgccgca tcaaagccgc attatcgtaa atatagctgt 2923261 aaacgccttt acgtcttcat ttgtaaaggc gttcttaata aaggaatttt atattttact 2923321 tctaatattt agtgttataa tagattcata ttttatacga aaggatttca cacgaatgga 2923381 aattctaaaa gactatcttc tgcacatctg ctttattttg tttcctattc ttctttacca 2923441 agtgttttgg cttggaaaac ctgcgattct tgtgccaaaa ataaacagcg gtttggtcac 2923501 gctcttcgcc tgcggcgcct ccgttttatg cattattttc ccgattcatg aaatggacta 2923561 catacaatac ggccttcaga tgattcccgt tatcatttgt ttattttaca ttagtaccgc 2923621 ttccggactt acagtcgccg catctgtcct atgttttgaa ctgctttttt acgaaccttc 2923681 cgcaatgttt gttttcactt tgctgccttt tcttatcatt atcccaatct tatttcagaa 2923741 aaaatggcca ttcatgtcca aagcgaaaaa actgctgctg tctttattga tcagctgcgt 2923801 ggagattttc ctatttttcg cctcaagctg gattctttcc gccttgaata ttttaaattt 2923861 tcaaaaatca ggaattttcg tttacgaggc ggcagtctca gggcttttcc gctccagtgt 2923921 tcttctatta agcatctata ttatcgaaag catcgccgaa aatatcgccc tgcgttcaca 2923981 gcttatccat tctgaaaaaa tgacgattgt gagtgaactg gcagcgagcg tcgcccatga 2924041 ggtcaggaat ccgctgacag ttgtccgcgg gtttgtccag ctgcttttta atgacgaaac 2924101 cctacaaaac aagtcgagtg cggattacaa aaagcttgta ctgtcagagc ttgaccgggc 2924161 gcaaggcatt atcacaaact atctcgatat ggccaaacag caattatacg aaaaagaggt 2924221 ttttgaccta tctgccctta tcaaagagac aagctccctt atggtgtcgt acgccaatta 2924281 caagtcagta accgtcgagg ctgaaacaga accggacctt ttgatatacg gagacgcaac 2924341 aaagctgaag caggctgtca tcaacctgat gaaaaacagt attgaagcgg ttcctcacgg 2924401 gaaggggatg atccacatat cagccaaaag aaacggccat acgatcatga ttaacatcac 2924461 agacaatggg gtcgggatga cagaccatca aatgcaaaaa ctcggcgaac cttattattc 2924521 cttaaaaacg aacggaacgg gactcggcct caccgtaacc ttttccatta ttgaacatca 2924581 tcacgggacc atttcattta acagcagctt ccaaaaaggc actacggtga ccattaagct 2924641 tcccgctgat cttcctcact agcaaatcga ttggaacttt aatagaataa atgcgaggtg 2924701 atgacagatg agcacgtttg agacaggctc tatcgttaaa ggattttaca aaacaggtgt 2924761 atacatagga gaaatcacgg cttgcaggcc gcagcattat ttagtgaaag tgaaagcggt 2924821 tcttacccat cccgctcagg gagaccttca tcatccaaaa caggcggatg tgccattttt 2924881 tcatgagaga aaagcgctcg catatggtga acagaccaat atcccccacc atatggtgaa 2924941 gccttatgac ggtgaagtgc cggattatac cgaatctctg cgggaggcga cagcacagat 2925001 gagagccaaa ttgaatgagg atggttcgga gtgggcaaag cgctcccttc ataatctgga 2925061 cattttagaa aaagaatatt ttaaccggcc ataacccagt ctgacaaaag attgggtttt 2925121 ttacgtcgcg cgcttcaaca gttcggttaa atcgattctc tcgccgattg tgggcggttt 2925181 tggcttttcg agatactgct tatcctgctc aacaagctta aaaagtttat atgctgtgag 2925241 agcatcatca agcgctttat gatgggtgcc ggttccggaa tctccatact cttcggcagc 2925301 tttccataaa cccgtcaatg tccggtctcc aaaaaagttt ttgtattcaa gcgataaatc 2925361 tctcatttct cccttaaacg ggaaagggat atggttaaac atacagtttt gcttcagcac 2925421 tttcatatcc atgtttcccc acgtaataat tgtgctgttt ttctcaggat ccagctcgtt 2925481 tagtttacgg atgaaatcct cgaatctcat tccttcgtct acctgttttt gggttatttt 2925541 taaaaatgat ttgcagcgtt tcgtaagctt cgggaacttt ttcggtctaa catagctaga 2925601 aaacgtctca accacttcat catcaatcga ctttacaatt ccggcttcaa tgatttccgg 2925661 gaagaagttt tgaggactgt actttccatc aggcattgta aattcgaaat caataatgag 2925721 taagctgttt gtcgtcacct tttacacctg cctttcctcc gatcagaaaa tgctatcttt 2925781 atagtatatc aattcccctt ctcgacattt cttcattttc taaaaataat gaattttccc 2925841 agccgcttcg tttcttttaa attgtgaatc gtttctttat aattagtaag gaacccgaaa 2925901 taataagaag gtgatgttat ttctatccgt aagaaaaact ttgtcattgt gtggctggcg 2925961 aacttttttg tctccgctag cacaacgatg atcgttcctt ttctctcctt atacattgag 2926021 acgctcagct ctttttcaaa cggctttgtg caaaggtgga gcggctatgt gttcggcatt 2926081 acatttctca tggcgttttt ggtatccccg ttttggggac ggttcggaga caaacgcgga 2926141 tacaagaaaa tccttatggc aaccggaaca ggcattgccc tcagcatttt cttcatgggc 2926201 tttgttacat cggtgtacca attgtttttt ctgcgtatgg caatgggtct tgtaaccgga 2926261 ttcatcccga catctcttgc gatgatttcg gcacagactc cgaagagctc agctggcaaa 2926321 acactcggca cgctgcaaat ggggcaagtg tccggaagct tgttcggccc gcttttggga 2926381 ggcatgcttg ctgatcgttt cggctttacg tatacctttt ttatcacatc ctttgtgatt 2926441 ttctcgtctg ttcttctcgt gttatttggt gtcaaagaaa agcatcttgc agagaaaaca 2926501 gccaaacgta cgtcttactc gagaaaagaa gtgctctcct atatttttca ccatccggcg 2926561 ctgtgggtca tgatgctgtt aaccatgctg attcaaacag gcaatttcag tatccagccc 2926621 ctgctcgctt tatatgtaaa tgagctgcac ggacctgtca atcttgcctt tttctccggc 2926681 atggcatttt cagcaacggg gctcggaagt ttgctgctgg ctagaaaatg gggtgatctg 2926741 ggcgaccgct acggccaccg ccgcatttta atcggacttt tgctcgccgc ctctttcttt 2926801 tttattccgc aggcgctcgc gtcctcactc agcgtgctcc ttgttttcag atttttattc 2926861 ggaatggcga tgggcggttt gctgccatgc attacggcag cgatccgcgt tcaggctccc 2926921 ggcagcattc aaggtgaagt tctcggctac aatgtcagct ttcgcttttt aggaaacgtg 2926981 ctcgggcctc tgctcggcgg aatcatatcg agccatttta ccatttcggc caccttttac 2927041 gtcacggcgt ttctcttttt cgccggcgcc tgcatgcttt ggatcatgca gaaacttcgg 2927101 aaagattctt atgccaaagc aagctgattc cgagaaaaaa ctaaggaatc ttctaaattt 2927161 aaccttctcg taatctcaaa agaatggtac gatatggcta gaatttagga gaaaagagag 2927221 tgaccatgtt acgaaaaata atcggatgga ttttgctcct ttgcataatc ccattgtttg 2927281 catttacagt tatcgcttcc ggaaaagaag taaaacaaat gaagtccctg gatcaggtgc 2927341 ttgataaaaa tattgatctg aaagatatca gccttgttca gaacagctac atgtatgaca 2927401 gggacggctc ccttgtctcg gaaatcgtca gcgaccacga aaaccgtgtg ctcgttccat 2927461 ttaacaagat tcccgaggaa gtcaaacaga ttttcttaac atctgaggac cgccattttt 2927521 acgagcataa aggctttgac tttatgggaa tggtgcgggc tactgcttct aacgtaaaag 2927581 acaagaaaat tgaccagggt gccagcacca tcacacagca gctttcaaga aacttgtatt 2927641 tgagccacga acgctccttc agccgcaagc tgacagagct cgcgtattcc tatcagctgg 2927701 agaaaaaata tacgaaaaat gaaattcttg aagcttactt aaataccatt tatttcaaca 2927761 acggtgttta cggcgtcggt tcagcagctc aattctattt cagcaaaccg ctgaaatctc 2927821 tcacagtggg agaaatggct tttatctgtg ctatacctaa taaccctaca ttatatgatc 2927881 ctctcaagca ttttgactac acgaaaagcc gtcaagaacg tttacttaaa gggctaaaag 2927941 atgccggggt cattacggac aaagagctga aaaaagccgt aaaacaaaaa atcaaactgg 2928001 atgttgaaaa aagagaagac aaatatcctg actacgtttc ctacgtcaat gatgaattca 2928061 ctcagctggt gtctgaatca gaaggctttg ataaacgcct tcaaaaagca tcaggaaaac 2928121 aaaaagaaaa gatcgagaac gagctgtccg caagagtcag cacgctgatg aaagacggag 2928181 tgaaaattta tactgcactt gatccgtaca tgcaaaatca agttgtggca caaatgaatt 2928241 ccaagctccc gtatgcggac gtacagggcg gagcggctgt gattaatcac cagacgcatc 2928301 aaatcattgc tctatccggc gggaaaaact atcaaaaata tgactttaac cgcgcctacc 2928361 aggcgtacag gcagccgggt tcatccatta agccgcttct tgattacggc ccttatattg 2928421 aacagaccgg cgcgacaaca agcagcacca ttgatgccag caagttttgc agcaaagact 2928481 actgtccgca aaactacaat aaccgcactt acggcacagt gacgcttgat acggcgttta 2928541 aaaattcata taataccccg gctattagaa tgctcgaccg cgtcggcatc caaaaggcat 2928601 tcagttatat tgagccgtat cattttgcca aacttgtcga cagtgactat cttcttccgg 2928661 cggcgcttgg cggatttaca aacggcatga cgcctcttga gatgacaaag gcttatacga 2928721 cattcggaaa cagcggaagc tatacgccga gccatgcgat tacaaaggtg acagacctta 2928781 aaggaaaaac actttataaa tggaatgata aagcgactca aatattcagc gtccgcacga 2928841 acatgcagct gaaaaaactg atgtcttccg ttgtgaaaag cggaacaggg aaaaaagcat 2928901 atttcaatgc gccttacatc ggcggtaaaa ccggaacatc aaatgattat cacgatatgt 2928961 ggtttgtcgg cctgactgat acgtatacaa tgggtgtctg ggtcggaaag gatacaccga 2929021 ccagcgttga atatcttcac agcatcagcc ctcagctttc catctggaaa ggaacgctgc 2929081 aagcggctta ttaaaggatc ggaggggata tggagtgact tcagaacaaa ttccaaatcg 2929141 cgttttgctg tttgacggtg tctgcaattt atgcaatggc gccgtgcagt ttatcattaa 2929201 acgtgatccg gacggattga tttctttcac atcgctgcag tcggaaacag gacagagcct 2929261 gctgaaaaaa agcgggcttc cgactgatcg gtttgacagc tttgtcttta ttgaagacgg 2929321 ccaagtgtac acaaagtcaa ctgcagccat taaggttttc aggcatctgc gaggcccatg 2929381 gcggctcttc gtcctttttt tcgcagtgcc gaagcctgtc agagatatgg tctattcttt 2929441 cattgccaaa aaccgctata agtggtttgg caaaaaaaat gaatgtatgc tcccctcccc 2929501 ttccattaaa aaaagatttt taccgtaaat aaaaaatggc taggaagcta gccatcacag 2929561 attgttgaca aaatcctaaa acggcttcgt tttaggattt tgtcatctat tcagcgtgat 2929621 tgaaaacttt tgaagttgtg aaacggcgga aacctgagaa tctagccgcc gtttcattgc 2929681 gtacagagca cgaagcgcaa atctgaccac caaacgctga aatggctagc ttacacaggt 2929741 aagctagcca ttatgctatt ataaagcttg ataaatatga acagaatacc gataacaaag 2929801 gtaaaccaaa acagcagttc caatagaatg aatccaacta atgacatgag agaaagcgtc 2929861 gaataaatcc ggtatacggt aaacacaaag taagcgagcg tgacgaccgc aaaccagatc 2929921 acaatccaaa tgacattttg caagagcaca aaggataaaa tcccgccgcc caaataaatc 2929981 atggaaccca ttctgagttt tttcaggttg ttcccttccg gatcattagc aaaaaacagc 2930041 aatgacagct cggtcacggt atttgcaatt aatttcagag cggacagaac cataaaatat 2930101 aaaagtgcaa aggcagcaaa taacgcaagc ctgattcctt tctctgaaaa ataatcgagc 2930161 attccatcat acattccaaa tgaagacagc atcttcaacg cataaagtga agttgagatg 2930221 gataaggacg aactaaaaag caggatcgca atcagcggaa aatatcctgt caaataagta 2930281 tttttcatat aaaaaagtcc ctttctataa tctacctcat ttattatgga ggacttaaaa 2930341 cacattgaca agataaatta ttccattttt tctccttttt acgaattacg ggcccaaatc 2930401 ttcacaaagc agcattttga gagtaaagta gtacgcagga atcataaaac gtaaggaagt 2930461 tttatatgaa aaaaacatta aaactgcaaa ccagactcac catatttgtt tgtatcgttg 2930521 tattaatcgc attgctcatt acgtttttta cagtcggtgc ccaaaccacc aaacgaatta 2930581 gagatcagga aaaggccact gcgctgcaga ctgctgaaat ggtagctgaa gcgccgatga 2930641 cagccgctgc tttagaaagc ggaaaaaaac aaaaggaact gcagagctac acaaagcggg 2930701 ttcagaaaat taccggcacg gaatttgttg tcgtcatgga tatgaacggt atccgcaaaa 2930761 ctcatcctga cccgagcaaa atcggaaaaa aattcagagg cggtgatgag tccgaggtat 2930821 taaaagggca tgtccatatc agcacagcct ctggcacgct cgggaaatcg cagagagcgt 2930881 tcgtccctgt ctacgcggag aatggaaaac aggtcggtgc agtcgcggtc ggcatcaccg 2930941 taaatgaaat tgatgaagtg atcagccata gcttacggcc gctttacttt attatttgcg 2931001 tcagcatctt cgtcggtgtg atcggagccg ttatcgtcgc ccgtacagtg aaaaatatca 2931061 tgtacggact tgaaccttat gaaattgcga ctctgcttga agaacggagc gcgatgctgg 2931121 aatcgacgaa ggaaggaata ctcgctgtcg atgaacatgg caaaattaaa cttgccaacg 2931181 cggaagcaaa acgcctattc gtcaaaatgg gcatcaacac aaatcccatt gatcaggatg 2931241 tagatgacat cttgccgaaa agccgcttga aaaaggtcat tgagacaaaa aaacctcttc 2931301 aagacagaga cgtccgcatt aacgggctgg agcttgtgtt taatgaagtt cctatccagc 2931361 tgaaaggaca aactgtcgga gcgattgcaa cattccgcga caagaccgag gtaaaacatt 2931421 tagctgaaca gctttccggt gttaaaatgt atgcaaacgc actgagagcg cagtctcatg 2931481 aatttatgaa caaactgcat gtgatattag gtctcgtcca gctgaaagag tatgatgatc 2931541 ttggagatta tattaaagat atagccatac agcaaaaatc agaaacaagt gaaattataa 2931601 atgatgtcaa aagctccgta ctggccggtt ttctgcttgg aaagcaaagc tttatacgtg 2931661 agcagggcgc aaatcttgat attgaatgca acggtgtcat cccgaacgcg gcagaccctt 2931721 ctgtcatcca tgaacttatt acaatcatcg gaaatctcat caacaatggc ttagatgccg 2931781 ttgccgatat gccgaaaaaa caaatcacca tgtccatgcg cttccataac agcatacttg 2931841 atattgaaat taccgatact ggagcaggca tgtctgaaga agaccaagcc aaagtatttg 2931901 aacaaggcta ttcaacaaag ggcaaaaacc ggggattcgg cctttatttc acacagcaaa 2931961 gcatcgaaaa tttaaaaggc caaatgatcc tcacaagcga aaagaatgaa ggaacgacat 2932021 tcagtattcg catcccgtac gaaccgaagg aggaaaatca tgattaatgt actaatagtt 2932081 gaagatgacc ccatggtggg tgaattaaat aaacgatact taagccaaat agatggcttt 2932141 cagctgaaag gcatcgcttc ttcctttcaa agcgctctgc atattttagg ggagcaccat 2932201 attgacctca ttttgcttga tatttatatg ccgggaaaaa acgggctgga actgctgacg 2932261 gaattgagag cccaaaatga agcggttgac gtgattgtca tctcagcggc cagcgagctt 2932321 gacgtgatca agaaaacact tcggtacgga gctgttgatt atttaatcaa accgtttgaa 2932381 tttgaacgat tccaaacggc tctgtctgat tacagacgaa aacaaaaggt gtattcaacc 2932441 catcgcaaca tgagccaaaa agaactggac gccgagcttt ttcaaaagaa agaagcaaca 2932501 gaaaaagtgc agcttcctaa aggcctgaca aaaagcacgc tgaagctgat ctggtccagt 2932561 atccagtcat ttgaaaatga atcttttacg acagaagact tggcaaagca cacagaaatc 2932621 tctcaagtat ccatacgaaa atacttaaag tttcttgaag atatacaggt tctgaatgta 2932681 gaaatggcgt acggaacgat cggaagacct gtgtttcagt acaacgtcaa caacagtaac 2932741 attaacggaa taaagcaata tctataagaa aacgcactgc ttgctttgag cagtgcgttt 2932801 ttctgtcata tctcttgcca agatgcttga ttctattgtt gataagttat acaagaataa 2932861 caaagggctt tcacattttt aagcaaataa ttctaaaaat agataatttt taaaaaatta 2932921 tgcgaaattc tatttatttc ttattagtta aatgataaat tatgattggt tagttgatcc 2932981 cgaaaaacta agtcataagt cttacttcag aaaacgatgt cacggttttc cgcccggaac 2933041 gccttccgca tccttctctt ccccgccttt cgaaggaaat actcacacca cgcttattca 2933101 gggaagaata gaactgtctc agcgcattcc atttgttatt atcagaaaat tttatcgatt 2933161 ctaagaaatt gttcaggaca gcccatcaca tgactggccg gatcagcttt gaaccaaatt 2933221 tttctggggg gttatatctt gaataaacga aaaatcggat tggcgatgtc acttgtgatc 2933281 gcagcaggca ccatattagg agcatgcgga aacagcgaaa aaagcagcgg ctcaggcgaa 2933341 ggcaaaaaca aattcagtgt ggcgatggtt actgacgtag gcggagtgga tgacaaatcc 2933401 ttcaaccaat cagcctggga aggcatccaa gcctttggga aagagaatgg gctgaaaaaa 2933461 ggcaaaaacg gttacgacta tcttcaatcc aaatctgatg cagactatac aacgaactta 2933521 aataaattgg cgcgtgagaa ttttgactta atttacggcg tcggctactt aatggaggat 2933581 tcaatcagcg aaattgctga ccagcgtaaa aatacaaact ttgcgattat agatgctgtt 2933641 gtcgataaag acaacgtcgc aagtattacg tttaaagagc aggaaggctc atttctcgtc 2933701 ggagtggccg cagccctatc aagcaaatca ggaaaaatcg gctttgtagg cggcatggaa 2933761 tcagagttga tcaaaaaatt cgaggtcggc ttccgtgccg gcgtgcaagc agttaaccct 2933821 aaagccgttg tagaagtgaa atacgcaggg ggtttcgata aagccgatgt cggtaaagca 2933881 accgccgaaa gcatgtataa atcaggcgta gatgttattt atcactctgc gggcgccact 2933941 ggcacaggcg tctttactga agcgaaaaac ctgaaaaaag aagatccaaa acgcgatgtc 2934001 tgggtcatcg gtgtcgataa agaccaatac gcagaaggcc aggtagaagg aacagatgat 2934061 aacgtcaccc tcacttccat ggtgaaaaaa gtagatacag tcgttgaaga tgtaacgaaa 2934121 aaagcgagtg acggaaagtt cccgggcggc gaaacactta cctacgggct tgatcaagac 2934181 ggagtcggca tttctccatc taaacaaaat ctatcggatg atgtgatcaa agcggtcgat 2934241 aaatggaaga aaaaaatcat cgacggattg gaaatcccgg caactgagaa agagctgaaa 2934301 accttcaaag ctgaataaga atcgcaggga taaggaggtc gagcccttat cccttgtttt 2934361 tcttttattt tgaaataaag gagcggtcaa tcaatggaat atgtcattga aatgctcaat 2934421 atccgcaagg cgtttccagg tatcgtcgcc aatgacaata tcaatcttca agtcaaaaaa 2934481 ggcgaaatac acgcgttgct cggtgaaaac ggagcgggga aatcaacatt gatgaatgtc 2934541 cttttcgggc tgtatcagcc ggagcggggt gaaattcggg tgcgcggcga gaaggtgcac 2934601 atcaacagcc cgaacaaagc gaatgacctt ggaattggaa tggtgcacca gcactttatg 2934661 cttgttgaca cctttacagt tgctgaaaat attattctcg ggaaggagcc aaagaagttt 2934721 ggcagaattg accggaagcg tgctggccaa gaggtgcagg acatttccga tcgatacggc 2934781 ctgcagatcc atcctgaagc aaaagcagct gacatatcag tcggtatgca gcagcgcgca 2934841 gaaatattaa aaaccctcta ccgcggtgcc gacattctga tttttgatga accgacggct 2934901 gttttgacgc ctcatgaaat taaggaactg atgcaaatta tgaagaacct ggtcaaagaa 2934961 gggaagtcca tcatcttaat cacccataag ctgaaagaga ttatggagat ttgtgaccgc 2935021 gttacggtta tccgtaaagg aaaaggcatc aaaacccttg atgtccgtga tacaaaccaa 2935081 gacgaactcg ccagtctaat ggtcggccgt gaggtatcgt tcaaaactga aaagagagct 2935141 gctcagccgg gagcggaagt gcttgcgatt gacggcataa ctgtaaagga tacccgcgga 2935201 atagagacag tcagagattt gtctctttct gtcaaagcgg gagaaatagt cggcatagca 2935261 ggcgtcgacg gaaacgggca atctgagctg atcgaagcgg tgacaggact ccgcaaaaca 2935321 gattcaggaa caatcacctt aaacggaaaa cagatccaaa acctgacgcc aagaaaaatc 2935381 actgaatccg ggatcgggca tattcctcag gatcgccata aacacggtct cgtccttgat 2935441 tttccaatcg gagagaatat cctgctgcaa agctattaca aaaagccgta ttcagcattg 2935501 ggcgttttac ataaaggcga aatgtacaaa aaagcacgca gcctgatcac tgagtacgat 2935561 gtcagaacgc cggatgaata tacacacgct cgggcattgt caggcggaaa ccagcaaaaa 2935621 gcgattatcg ggcgggaaat agaccgaaat cctgatttat taattgccgc ccagccgact 2935681 cgcggccttg atgtcggagc gattgaattt gtccataaaa agctcattga gcagcgtgat 2935741 gccgggaaag ccgttcttct cctctcgttt gagcttgaag aaattatgaa tctcagtgac 2935801 agaatcgccg ttatttttga aggacgcatt atcgccagcg ttaatccgca ggaaaccact 2935861 gaacaggagc ttggtctctt gatggcagga agcacgcaaa aggaagcggg gaaagcaaat 2935921 ggttaaacga ctctctcatt tactcgtgcc gctcatcgca atcatacttg gtcttgcggc 2935981 cggcgcgttg attatgcttg tgagcggcta cagtgtggct agcggatatt cggctttgtg 2936041 gaatgggata ttcggagaaa tctattatgt cggagaaaca atccggcaaa ttacgcctta 2936101 tattttatcc ggattggctg tcgcctttgc attccgaacc ggactcttta atatcggcgt 2936161 cgagggacag ctgctcgtcg gctggacagc agcggtttgg gtcggtacgg cgtttgacgg 2936221 accggcatat attcacttgc cgctcgcatt gattacagcg gcagctgcag gaggattatg 2936281 ggggtttatt cccggcattt tgaaagcgcg attttacgtt catgaagtca ttgtcaccat 2936341 tatgatgaat tatatcgcgc tgcacatgac caattacatc atttcaaacg tcttgacaga 2936401 tcatcaggac aagacgggga aaattcacga atccgcctcc ctccgctctc cttttcttga 2936461 acagatcacc gattactcac ggctgcattt gggaatcatc gttgcccttc tcgcagcagt 2936521 tatcatgtgg tttatcatca acaaatctac aaaaggattt gagctccggg cggtcgggtt 2936581 taaccagcac gcttcccagt atgccggcat gagcgtgcgg aagaatatca tgacctccat 2936641 gcttatctcc ggcgcttttg caggtcttgc cggagccatg gagggcctag ggacattcga 2936701 atacgcagca gtgaaaggcg catttaccgg cgtaggcttt gacggtatcg ctgtcgctct 2936761 tctcggggga aacacagccg taggcgttgt actggcagca tgcctgcttg gcgggctgaa 2936821 aatcggcgca ttaaatatgc cgattgaatc aggcgttcca tcagaggtcg ttgatattgt 2936881 gattgccatt attattctat ttgtggcttc aagctatgcg attcgtttcg tcatgggcaa 2936941 attgaagaaa aagggggcga actaagtgga cattgtgcag attttatcta tcattgtccc 2937001 tgccacactc gtctatgcgg ccccgcttat tttaactgct ctcggcggcg tgttttccga 2937061 gagatcaggt gtggtgaata tcggcctaga aggcctcatg attatcgggg cgttcaccag 2937121 cgtgttattt aatttatttt ttggtcagga attaggtgcc gccgcacctt ggctttcgct 2937181 ccttgccgcc atggcagcag gcgccctgtt ttcactgatt cacgcggcag cggcgatttc 2937241 gtttcgcgcc gaccagacag tcagcggtgt cgccattaac atgctggcgc ttggggcaac 2937301 tttatttatc gtcaaactga tctacggcaa agcgcagaca gacaaaattc cagagccttt 2937361 ttataagacg aaaatccccg gtttgggcga tattcccgtc ttgggaaaga tcttcttttc 2937421 ggatgtctat tatacgtcta ttcttgcaat agcacttgcc tttatttcct ggtttatctt 2937481 gttcaaaacg ccgttcggcc ttcgtatccg ttctgtcggc gagcatccga tggcggccga 2937541 tacgatggga atcaacgtat ataaaatgcg ctacatcggc gtgatgatca gcggattgtt 2937601 cggcggtctc ggcggcggcg tatatgcctc cacaattgcg cttgatttca cgcactctac 2937661 catctccggg caaggtttta tcgccctggc agcgcttgta ttcggaaaat ggcatccgat 2937721 cggagcactg ggggccgccc tgtttttcgg attcgcccaa agcttaagca tcattggatc 2937781 gctgctccct ctttttaaag acataccaaa tgtgtatatg ctgatggctc cttatatctt 2937841 aacgattctc gctttaaccg gctttatcgg gcgggcagat gcgccaaaag ccaatggcgt 2937901 gccttatatt aaaggaaaaa gataaacatt ctcccctggg aagacgattc tcagggattt 2937961 ttttctaatc caaaagaccc ccttaattta attgtttatt agttttttaa cttaaaaaaa 2938021 tatgaagtgt taacgctttc ttgtagactg taacaaacaa tacatggggg tgtatgacat 2938081 gggagcaatt ccaaaaacgg ggacaatttc acctgagcaa aaagactcac aggagaaaaa 2938141 cctgtttcaa aaaatttggt cttgggaaat cggtgtgatt cctttgccat tatacacagt 2938201 attagctgtt attattattc ttgcagcata ttacaatgag ctgccggcaa atatgcttgg 2938261 cgggtttgcc atcattatga ttcttggtgt gtttctcgga gacataggcc aacgcatacc 2938321 gatattgaag gatattggcg gccctgctat tttatctttg tttgttcctt catttttagt 2938381 cttttacaat gtactgaatt caacatcttt agacgctgta accaacttga tgaaaacgtc 2938441 taacttcctt tatttctata tcgcttgcct tgttgtggga agtatcctcg gtatgaacag 2938501 aattgtttta atacaggggt ttatcagaat gttcgttcca ctggttgcag gaacgatcgc 2938561 ggccgttgca gccggcatcc ttgtcggatt tatttttggc tatagtgcct atgattcctt 2938621 tttctttgtt gttgtcccga ttattgccgg gggaataggt gaagggattt tgccgctttc 2938681 aatcgcctat tcacaaatac tgggctcatc cgccgatgta tttgtgtctc agctggtgcc 2938741 agccgcaatt ataggaaacg tttttgctat catatgtgca gccttaatga aaaagcttgg 2938801 cgacaagcgt ccagatctaa atgggaacgg acgtctcgta aaatctaaaa aagcaaatga 2938861 gattttcaat caaaaagaag ccgaagcaaa aattgatttt aaactaatgg gagcaggagt 2938921 tctgctcgcg tgtacattct ttatttttgg cgggttattg gagaaattca tcttcatccc 2938981 gggcgcgatc ttaatgatta tttcagctgc ggctgtcaag tatgcaaata ttcttccgaa 2939041 aaaaatggaa gaaggcgctt accagcttta taagtttatt tcttcaagct ttacatggcc 2939101 gctgatggtc ggtctcggca tcctctttat tccgttggat gacgtagcgt ctgtgatttc 2939161 tataccgttt gtcatcatct gtatttcagt tgttatcgcg atgattggtt ctggatattt 2939221 cgtaggcaag ctgatgaaca tgtatccggt tgaatccgca atcgttacct gctgccacag 2939281 cggtctcggc ggaacgggtg atgttgccat tttatcggca tcaggaagaa tgggccttat 2939341 gccgtttgcc caaatttcaa cccgtctcgg cggtgcaggc acagttattt gcgcgacagt 2939401 gctgcttcgt tttttcactt cataaacaga aagagttccg ttttatgcgg aactcttttt 2939461 ttatttattc acaatccgaa tatactctcg gggaccaaac ggcagatcct ttgattccgt 2939521 ctcactcatt ctggctgaca ggtggtgctc cagtaaatac agctcccact catcacaagc 2939581 cgccacaccg ctgcgcccgt catattgatt caacatgaat gcccctgcaa atactgagca 2939641 gaataaacct gagcacatca cgacttttgt tttcacatga ccagctcctt tccttcagct 2939701 tgatcaggat tgattttaaa tatacaaata acctcttttt tgttagactt attttgaggt 2939761 caaaagaact cataaaaatc cattacagca gttcgaagcg tggcagcttg cagaaaagtg 2939821 cgatataatt tggactaggt cgtttgaccg tatattttat acatagcgca tttttcaatt 2939881 gagaacgaga aaaggaggtc ttatctttgc agctcttaca tcttgctatt ttatcgcctt 2939941 ttttatttgc ttttatcatt cccttcttgg caaaatacgc aaaaagagtg catacgggct 2940001 ggtttgtgtt gatcctgccc gtcttgctgt ttatatactt tctcccaatg atcaggatga 2940061 cgcaatctgg agaaacactt cgatcggtat tagagtggat tccgtcactc ggcattaact 2940121 ttaccgttta tatagacggc ctcgggttat tattcgcttt actgatcaca ggcattggct 2940181 ctttggtcac tctttacagc attttttatt tatcgaaaga aaaagaacag cttgggccct 2940241 tttatgtcta cttattgatg ttcatgggcg ccatgctcgg cgtcgttcta gtagacaatg 2940301 tcatggttct ctacatgttc tgggagctta caagcctttc atcctttttg ctgatcggct 2940361 attggtataa gcgggaaaag tcgcgctatg gcgcagccaa atcacttttg attacggtca 2940421 gcggcgggct gtgcatgctc ggcggattta ttctccttta tttgataacg gattccttca 2940481 gtattcgaga gatggttcac caggttcaat taattgccgg ccacgaattg tttatcccgg 2940541 ctatgattct cattttatta ggggctttta cgaaatcggc gcaatttcct ttttacatct 2940601 ggctccctga cgcgatggaa gctccgacgc ctgtcagcgc ttatctccat tcagctacta 2940661 tggtaaaagc cggcatttat gtgattgcga gattcagtcc tattttcgcc ttttcagctc 2940721 agtggttttg gatcgtgtcc ctcgtcggcc tctttacgat ggtttggggt tcattccatg 2940781 ccgtgaaaca aactgattta aaatcgattt tggcgttttc aaccgtcagc cagctcggca 2940841 tgatcatctc catgctcgga gtcagtgctg cggcccttca ttacggacat acagaatatt 2940901 atacagttgc cgctatggct gccattttcc atttgatcaa ccacgcaacc tttaaaggaa 2940961 gcttgtttat ggcagtcggg attatcgatc acgaaacagg cacacgggat atccggaagc 2941021 taggcggcct gatggcgatt atgccgatta cttttaccat ttccttaatc gggacatttt 2941081 caatggccgg cctaccgccg tttaacggat ttttgagtaa agaaatgttt ttcacaagca 2941141 tgcttcgcgt gacacatttt gacctgttca acgtgcagac atggggcgtt ctgttccctc 2941201 ttttcgcctg gatcggaagt gtatttacgt ttatctacag catgaaattg ctgtttaaaa 2941261 cattcagagg aaattaccag cctgaacagc ttgaaaaaca ggctcacgaa gcgcctgtcg 2941321 gtatgctcgt tccaccggtc attcttgtcg ctttggctgt cagtctcttc tttttcccga 2941381 atatattgtc gtacagcctg atagagcctg cgatgaactc aatctatccg acactgcttg 2941441 acggccatga gaaattccac gttcacattt cacagtggca tggggttaca acggaattgc 2941501 tcatgactgc gggtattgtt gtgatcggaa caattggtta tttgtcgctg aataagtgga 2941561 aaggaatcta taaactgttt ccttcgaaac tcacactcaa ccggttatac gataagcttt 2941621 tgactatgat ggagaaaggc tcttaccggg tcacaaaaca atatatgacc gggtttttaa 2941681 gagattattt gctgtatatc ttcgctggtt tcatcattct gataggcgga gcttttgcca 2941741 ttaaaggcgg attttcattt aaaacggaag gcatggctaa aatcggtgta tacgaaatca 2941801 ttttgacgct tgtcatgatc agcgccacag tggcgactgt ttttgctagg tcaagactga 2941861 cggcgatcat tgcactcggt gttgtcggtt atacgcttgc attgtttttt gtcattttca 2941921 gagcgccgga cttggcattg actcagctcg tcattgaaac gatttctgtg gcactgtttc 2941981 tgctttgctt ctaccatttg ccgaaactga ggctgaaaac aaaaacgaga acgttccgga 2942041 tgacgaattt tatcatttct ttaggcgtcg gtgttatcgt tacactgctc ggcatcgcat 2942101 cctcaagcca gcggacaaaa gacagcattg cgtccttctt tgtcaaacac agccacgatc 2942161 tcggcggagg ggataatgtc gtcaatgtca ttctcgttga tttcagggga tttgatacaa 2942221 tgtttgaaat tacggtatta acgatagccg ctctcggcat ttacagcatg attaaaacaa 2942281 aagtaaaaga ggaggggaaa agcggtgaat gaacaaaaaa caaatgactt gattcttcaa 2942341 accgcgacaa agcttgtatc ctttatcatt ttgcttttct ctttctattt atttttatca 2942401 gggcataacg cgcccggagg aggctttgtc ggcggactga tcacgtcctc ttccatcgtt 2942461 ctcttgctct tggcatatga tttaaaaacc gtgcgttccc ttttgcctgt caatttcatt 2942521 tatgtcgcgg gagccggcct tctgctcgct gtattaacag gcgttggctc ctttgtcttc 2942581 ggggctcctt ttttaaccca cacattcgga tactttcagc tgccgatcct tgggaaaacg 2942641 gagctcgcca cagcgacgat atttgattta ggcgtttatc ttgttgtcgt aggcataacg 2942701 atgaccatta ttcaaacgat tggagaggaa gaataatgga aatcttaatg gctgtattag 2942761 ccggtattat ttttatggct gctacgtatt tgctgctgtc taaaagcctg cttcgcgtca 2942821 ttatcggaac agcactgtta agccatggcg ttcatttaat gcttttgact atgggaggat 2942881 taaagaaagg cgccgctccg attttgagcg agcatgccaa atcatttgtc gatccgcttc 2942941 cgcaagccct gattttgacc gcaattgtca tttcttttgg cgttacgtca ttcatcctcg 2943001 tcatggcctt tcgcgcttat caggaattga aatcggacga tatggatcaa atgaggggaa 2943061 atgatcaaca tgaataattt tgttattttg ccaatcctga tcccgctttt gtcggctatt 2943121 cttctgattt tcatgacgaa gaatcttatg ctcatgagaa tcttcagcac ggcggcatcg 2943181 gccatcggga ttgtgattag cggcatactt gtacagactg tcttcacaaa aggcatccag 2943241 acactcagcc taggcggatg gaaagcgccg tacggcattg tgcttgccgc agaccaattc 2943301 gccagccttc tcgttctcac aacagcgatc atcggtttat tggttgggct ttattccttc 2943361 cgttctgtcg gtgaaaaacg ggagcgctcc ttttactact ccggcgttca gttcttgctt 2943421 gccggcgtca gcggagcgtt tttaacaggc gatttattta atatgtacgt attttttgag 2943481 cttctgctta ttgcttccta tatgctgatt gtattaggcg gcacaaaaat tcagctgcgg 2943541 gaatccctta aatatattgt gtttaatatt gtatcgtctg ccctgtttgt cataggggtc 2943601 ggctttttat acgctgtaac cggtacgtta aacatggcgg atcttagcgt gaaaatcagc 2943661 gaatcaggac aaaccgggct gatcactgtg attggtgtcc tgctgctttt ggtatttggc 2943721 atgaagggcg gaatcttccc cctctacttt tggcttccag gctcttatta cgcgccaccg 2943781 gcggcaatct ccgcgttgtt cggcgctttg ctgacaaaag tcgggttata tgcgattacg 2943841 agggttttca cattgatttt tattcacgat acagccttta cccatcagtt gatgatttgg 2943901 ctggcggcgc tgactgtgat ttttggtgtg atcggttcac tcgcttattc gaatgtcatg 2943961 aaaattgtga tctataacat tattaccgct gtcggcgtga ttttgttcgg tgtggcagta 2944021 cacacccccg catccattca gggcgcgatc tactatctga ttcacgatat gctgattaag 2944081 ggcgctttgt tcatgctggc aggtacgctg atcgcattga ctggaaccgc gagcctgcat 2944141 aaaatgggcg ggctgatcaa acgctatcct gttcttggat ggatgttttt catttccgct 2944201 atttctcttg caggcattcc gccactgagc ggatttgtcg gcaaatttaa aattgcagag 2944261 ggcggcttcg cagaaggtga atttacgata tccatgctga ttctgctttc gagtctgctt 2944321 gtactgtact ctgtgctgag gatctttata catgcgtttt ggggcgaaga aaaagaaacg 2944381 ccaaaaccaa atcatcgaac agctaaagga cttctttatc cggcagctat ttttctcttg 2944441 ctgtcccttc tcttcggatt gggtacagaa tgggtgtcgc cttacgttga tcaagcggcc 2944501 gagacgctgc tgaatccgga aaaatatatc gaagctgttc tgaaggagta gatcgcatgg 2944561 catttcaaat tttattaaat gtgtttctcg ctttttgctg gatgttctta agcaacagtc 2944621 caagcgccgc aggattcatt acaggctata ttctgggaat gctctctctc tttttcttcc 2944681 ggcgcttttt cactcgccag ttttatctat ggaaattgat ttctattatc aagctctgtt 2944741 tcatttttat aaaggaactg taccttgcca atgtcagtgt gatgaaatca gtcttatctc 2944801 caaaactgaa tatcagaccg ggtatttttg cttttaaaac tgaactgacg aaggactggg 2944861 aaatcaccat gctttctctg ctcattacat taacgccggg aaccttggtg atggatattt 2944921 cagatgacag aacaatactt tatattcatg caatggatat cgaggatgcg gaaaaagcga 2944981 tttttgacat tcgggagtca tttgaaaaag ccatacagga ggtgagccgg tgatgtttac 2945041 gctgatcctg caaatcgcgc tcggcattat ggcagtgtct acctttttgt atgtcattcg 2945101 tgtcattaaa ggtccgactg tgcctgaccg ggtcgtggct ctggatgcaa tcggcatcaa 2945161 tctgatcgca atcacggcgc ttgtctccat tttgctgaaa acaagtgcgt ttttggatat 2945221 tattttgttg ctggggattt tatcgtttat cggaacgatc gcattttcca agttcctgga 2945281 gaaaggagag attatcgaaa atgatcgaaa ccgctaaggt cgttgtggct gtattcattt 2945341 tgctgggtgc tcttatatgc ctcattgctt catttggcgt acttcgcctt cccgatgtgt 2945401 ttacacgcgc tcatgctgct tctaaaggct caacattagg tgtcaatatg attctgctcg 2945461 gtgtcttctt ctatttgtgg tttgtgacgg gggagctctc cgctaaaatc ctgcttggga 2945521 ttctctttat ctttattacg tcgcctatcg gcgggcactt gatctgccgt gctgcgtata 2945581 actccggcgt caagcttgat gagagaagtg tgcaagatga ctataacgga atcagaaact 2945641 ttgtgattaa acgaaaagag gattcttatt tataaaaata agcagccgga caggcagagt 2945701 tccggctgtt tttttatttc ttgatgacag ccagcgtgca tctggatata cagatcagcc 2945761 tctcttgctc gtcatatatg tgaatatgat agacaatcgt cgttctgcct atatgaacgg 2945821 gctcggctat cgcctttacc gttccttcct ttacagattt taaatggttg gcgttaatct 2945881 ccaaaccaac acaagcttgc gttgtatgat caatcaggtt ctgtgcacct gcgctcgccg 2945941 cggtttccgc cagggccact gaagcgcctc catgcaaata tccgaacggc tgtaccgtcc 2946001 gatgatccac cggcatgacc gcaacgcatc gttccgctgt gttttcaaca atctcaatac 2946061 caagcgcttc aagcaatgtg tgcttcatat ccatctctac accccccaac atttaaagta 2946121 caccgtctga tttcgcaatc aaaaccgctt ccgtccgtga accgacattc agcttattga 2946181 aaatcgatgt caagctgtat tcaatggacc gcttgcttaa atgaagggca tctgcgattt 2946241 cttggtttgt aaatcccttt tcaacttctt gaagaatcag gcattctcta ggtgtgagca 2946301 catcttgttc tttttgagag gaaggagccg gctttgtttt ttgctgagtc atcagctgtt 2946361 taaagtaagc aaaatcgact aaaatttctc cgttgagtac gtggtatatg tattgggtga 2946421 tcttttcttt agattccgtt ttgctgatgg caccgtgcag acccgcacga atcgcttcct 2946481 cgaaataatc ctcgacctca taaccggtat acacgataat tttacaatga ggattctctt 2946541 gtaaaatctg tttagaaagc tccatcccat tgacctcgcc gcctagattc agatccatta 2946601 aaatgagatc atatgacgag aaatcatgct gcttgataaa ctgttcgctc ggttcaggac 2946661 tgagacaatc aacagacaaa ttcgaatccg tttccaaaat tgtcttggtg ccttccatga 2946721 cagccggatg gtcatcaatc actagtatct ttttcatgtt ttcctccctt ttactcactc 2946781 ttttccattt tataaaaaag acttggcctg tgccaagtcg tttccgttat aaatccatta 2946841 caattcgatt tcaatatcag ccttaaagcc ctttccttca cttgtttcaa tccgaaggcg 2946901 cccatctaaa gccctgactc tctccttaat gccagaaagc cccatgctca tggaatgctc 2946961 agtatttttt tcttgatcaa acccaacgcc atcgtcctca taatgaagaa cgattttgtt 2947021 ttgaatactg atgagcataa tcagcacatc cgtcgcctga gagtgcttga ccgcattaga 2947081 cagaaactct tgaatgatcc ggtacaaatt cagctgcgaa tccagatcaa gggaagccgt 2947141 aaatctcccg gtatttaaac ggatatgaaa cggaacccgc tcctgctgct gcgccaccag 2947201 cttcgacagc gccttcacca atccaagatc atacagaagc tgcggccgca gctcatgaca 2947261 cgtctccctc gtcatcgaaa tcacatcaga catctgctca ttcatctgta caagcttgtc 2947321 ctgcacctct tcacggcacg gattatcatc cttcttgaaa tcacccaaaa acagctcaca 2947381 ctggcgtttt aaggaaatca aatcctgaag aaccgaatcg tggagatcgc gggcgagtcc 2947441 tgaacgctgt ttttcttcga ttgcaaacat tagctttttc agccagatgg ggttggttcc 2947501 ctcttgtttt aagtccttca aatgttccat gagctcctca atatgcagga cattttccat 2947561 ggacacactt gtataaaaag acagtgtttt cagccacgat atttcatcac gtgttagccg 2947621 gggagtgtta atattagata aacaaagcag aacataagaa ctaccgcctc gttcaccaac 2947681 tttcataaga aagccttgat tgacttctat aattttccca atttctgaag ttacgttttc 2947741 aaattcctct tgataaaaat tccagtccgg tccaacttca tgcttatcta aaaatatcac 2947801 tttgtgatca ggagtaacct caaaggtata agctttgctt acaagcaaaa catccagtat 2947861 agtatttttc agttctttaa aaacttgttg aagagaagtt acacccctca ttagctgagt 2947921 atatttaaaa atactgtcct gatagttgaa tttttcggag aaacgtttta accgaaattt 2947981 aaaatccatg acctctttaa aataaaagac agcgaacatg acaacgaaaa aaaatacagt 2948041 ttgacgcaca gggttcatct ggatgtccat tacatcaaac agaactaatg caccaactat 2948101 tagaagagtt ggtatcatgg caagtagagc atagtatctc attcttccta agataaactc 2948161 tatatcaaac atcttattgg ctacaaattg gtatactaac ccgaacggaa ttagtactag 2948221 taatgacgcc gaagctaatg ccgggaaaat ataattacct gtaaatatta ttggaagaac 2948281 aaaaaatatc aaaaaaggcg caaatgaaag agtgtttgtt aaaattagta atttaagaat 2948341 aaacgaatgc tcagcatatt tatatttatt aagatgtaag tatatcgctg aaaaagaaaa 2948401 tagagtcaaa gttgcaaaag aaaccaaatt aagagttgct aaaaaatcaa tatctacttg 2948461 taaatagtct tgaaaaaact caataccaag attaaatatt ggtatgatat aaagaaaaga 2948521 aattctattc aaaaaagttt tacctatttc tccaaggtat ctttgtataa attgaagata 2948581 aagaatagga gaagatataa aagtaaacaa gttaatatac cgattgatta tatgtcctct 2948641 aaatggtccg cctgcactta tatatgctat cgaaatgtct aataacaata gaataagaat 2948701 ataggcagca aatgatctcc tttttttatt tactttaagt atataaaaaa tacatattat 2948761 gcttaaaaaa taaaaaaaca aaggaagtac gaacagaaaa aaactataag gtctatttag 2948821 agtaactaaa tcaaaatctt tgagatgaat cttttttcca cttctcaaaa tatccagact 2948881 gttaatatga ctcaaatatc cccatttcaa atgtttgtct gaaggttttt ctttattaat 2948941 ttttaatatg atgtctccct gtctcagacc aacaaattgt ccatatgaag attccgatat 2949001 ttcttctatc ataaattgac ttttatcatt tttatgaatc ttagtcccaa taataattcc 2949061 attcatactg atataagttg tatagcttat ataaaggata ctcaaaacaa ttacagctat 2949121 tgtgaatttt tttattaagt tcttcaatat taatccacct attaatcacc ccattgacgg 2949181 gttattggat cagccagata ataatcatta taagctttaa ttattgtttc agtttcttgc 2949241 acatcaaaac ctataaggca ggcttcttta tttttcaatt tttttaaagc ctcaggataa 2949301 tttaaaaagt agttaattag gtcttgcatc ttgtatcccc ctttgtataa cttaataagc 2949361 attcctttat tagctctttt ttttctttat ctaaatttaa ttgttctata gcagaaatac 2949421 atttctgttt atatatttcc aataataccg aaatgtattg agtaactccc gctttaatta 2949481 atttttcttg gaatttctct ttatcaagta acgatttata atataagtct ttatgtgaaa 2949541 ttaagtataa taaatcttcc gaagcatcat taaaaaggcg cttaagatat aagtaaatca 2949601 gtgtatgttt gtttttttca atatcactgc gatttccgga taaaagaaca taataatctc 2949661 cagaaatttg agctataatc cctttatagt aggaatatct ttcaactgtt tcattatatt 2949721 ctcctgtagc caataaaaca cctgctacat ttgctagtgc aatcagactt ccacatttta 2949781 atctaattac ttctaaactt tcatcttctg ttttagattt attagtgata tcgtcatgtt 2949841 gaccttgcat ggcctcgttt acgtatttta aaacatattt aaaaattaga ggattgttat 2949901 ttaatgaata aatactcgtt aatcctactg tatacaagga aagtgctgca tttaacgact 2949961 ccgagcgatt aattttcatc cataatgcat ggtgattatc ttcatcttca agatcatcca 2950021 taatatctga tgaaagaata agaatttcta ttcccgcgcc aagccttgtt gcaacatcta 2950081 aattctcccc tccaaaaaca acataatgta agattgtgga ttcagcaaag gagaatgttt 2950141 ctttagaatc aataaatgag taaagaagtt gtgacaaatc ctcgttaaat atgttttgct 2950201 ccacaatctc cttcattttc tccttgatcc ggacagaatc taaacatatc tgctcaataa 2950261 cgacttcccc cctcccattc cattttacta aatgggacat ttaaaggaca gcaggttttt 2950321 cgttttttaa caatcatata atactttatc catttattgt atcggtagaa cgaaaaaaaa 2950381 gacttgtttc caagtctttt tcacgaaatt ttcattgcat aattgtattt atcgagttga 2950441 tcaatgcttt tgttaatgtt tcgtaatgaa tctgtcgttt ctttaatatc aagttcgagt 2950501 cggaataaca attgttttac ttcttcaagt ttcttttcca tcgtttccac actccttttt 2950561 ttgaaagatc aatgaattgt gtatggtgaa cgagtcctag gtatttgatc tgttactaat 2950621 agtgtgtctg ctttcggctc atttttcacc gaaaagtatg caaaaaagtc ctgcgtgaca 2950681 ccgcaaatct caataggtcc ttatactcaa aggaatcaca acaagaacgg gactatcttt 2950741 ctatgcgaaa gagcgtttat atgtgctgaa attgagaaag attcttaatc tccttgattt 2950801 taacgggttt cgcattttca ctaagcaaga ctatagtcct tcataccgta ttttcaaaat 2950861 tgaatatgcg attcttggcg tttcctgacc gacaaacacc gaaaaagacc gcaacgctaa 2950921 agttgtggcc ttttcgcttt gtcatattcg gcaattaggg atctatacat atagaaacat 2950981 ccttttttgc gaggtgctcc catgagatat cgttatccct ggttttacgt gtatccgtat 2951041 gaggtacgcc gtccgcccgc tcctgccaac aatattgata cctttatccg ttcagcgaag 2951101 caggccgcag ggatatttgc ggatgcccag ctcgttctca gccgcattgc gggctcgcgg 2951161 gagctttcgc gccgcattct gaccgcagcc gaacagtctg ataaacaaac tataaggcgc 2951221 ctgatcaaac aaatgggcgt ccggcatgaa gtggatacgg tctttaatcc cgacggcatc 2951281 tatatcagcc ttatcggaac gcaaagccga atgattcttg ctttgcggtg gtcagaggac 2951341 cgcaatcatt ttgcgtccat aagattatga caccattcca gagcctctaa ataacattca 2951401 tacgcttctt ctttgtccag ttgattgcct aattctgagc aagtgtccca gttgttgctt 2951461 tcaattaatt tcacaagctc aagcatttgg tagtagtcgt tttgatggcc taataatgct 2951521 tgcccgactt catcttttaa aggcaattct tgaacaattt cctctatttc tctatgcagg 2951581 agggtgtcta tgagagaaaa cattccgatc agcatataag aagcaggctg cggccgggat 2951641 gtctttctcg ccagcagttc gcaaagcttt gctcttatca gagaaatctt aatgatttcg 2951701 tgcttgctgg aatgcccttt cctgcttaaa tccttaaagg aaagaatata tatccaccgt 2951761 ttgatttcat taaatcccag cagcataatg gcctgttgaa tgctttcaat tttctggctc 2951821 aaacggctgt gggatgagtt taaaaatttt aaaatttgat aggacagtga taaatcccgc 2951881 tctatgtact ctgtcacacg ctttatgtta ggctgctctt tactcagttc gttaagcagt 2951941 tcatagtaag aatagaaatg agtcgatagg tcatgcccgc tgatgatgcg cggctcgctg 2952001 aaaaagtagc cttggaataa ttgaaagccg tcttggaccg cctgtttata ttcttttcgg 2952061 gtctctactt tttccgctaa aaaaatcagg ccgcggcagc cgtaggtttg caaaattgtt 2952121 ctgcgttcca ttcgtgttgt tttgagaaaa tcaattttca atatatcaat atagctcatg 2952181 agtttttcca gtaagtcctc atcttgcgga tttattgcat aaaaatcatc aagcgccagc 2952241 atatacccca tttttttcaa ttctttgcat ctagaaatga gggccggcgt gatcggtata 2952301 tcttcaagga tttcaatgac aagctgtttc ggattgaagg aggtgggaag attcgaaaac 2952361 atcaggcttt ccgtaaaatt aacaaaacag cgtttccctt ccgtcagctt ctcaattccg 2952421 atgtttaaaa agctgttgat caccaaatct gttgttgcct gatcgccgtc tttagcgcta 2952481 tacacgttct cttcgctttc tctatacagc agttcataag caacaacctg ttcttttcta 2952541 ttaaaaatag gctgtcttgc aacaaacacc ctcattgatt tatccccctt acaatacgcg 2952601 cggctttcac ccctaagtat atcaaataat ttgacgaaaa ttgtctaaac atgaaaaata 2952661 atatatacat aaagaaaact ggcccttcgc gaatgaaagg ccagtttttc tttattcttc 2952721 ctcaagctct tcttcaattc tgcttttcac ttcgtggatc cgctgcattt tattgctcca 2952781 gcagtcctcg cttaaatcaa ccgggtattc ctccggcttg ctgattctct tatattcctc 2952841 ccaaagcagg ctgaggttat cctgcacata ctgctgtatg tctgaaatct cagggttttg 2952901 gtagcaaaga atacccttct caaaaatcag ttcatgaaga tccttcgcat aaaaattcgt 2952961 gacaaatttg ctgatgaatg tatgaaccgg gtggaacatt ctgagccgct tctgatcatt 2953021 cacctgctca tcataaagcg caatatagtc gccttcagaa tgatggttgg actgattaat 2953081 aatgcggtag actttctttc tgcccggtgt cgtcactttt tcaggattgg acgaaatttt 2953141 gatcgtgtcg accattttcc cgtcttcttc aatggcaacg agtttataaa ctgcgccgag 2953201 agccggctgg tcataggcag tgatcagctt cgtaccgaca ccccagacat caatgcgcgc 2953261 tccctgagcc tttaaattca taatggtgtg ctcatccaaa tcgcttgaag caatcacctt 2953321 cgcatctgta aatcctgctt catcaagcat tttccgggct ttttttgaca ggtacgccaa 2953381 atcgccgctg tccagacgga tgccaatgaa attaatgcgg tcgccgaatt ccttggcaac 2953441 cctaatcgcg ttcggcatgc ctgaacgaag cgtgtcatac gtgtcaacta agaagacgca 2953501 atccttatgt gtttccgcgt attttttgaa agctgtatat tcatcgcggt aagcctgcac 2953561 aagcgcatgc gcatgtgtgc cggaaaccgg gatattaaag cgctttccgg ctcttacatt 2953621 gcttgtcgcg ctaaagccgc cgattaaggc tgctctcgct ccccacatgg ccgcatccat 2953681 ttcgtgcgcc cgtcttgttc cgaattcaag cgcaacttca tcaccgatga cgcctttaat 2953741 ccgggcagcc tttgttgcga ttaatgtttg atagttcaca atgttgagca aagctgtttc 2953801 aatcagctgc gcttctacca ggggtgcctc caccctcata atcggctcat tgttaaaaac 2953861 gagttctcct tctttcatgg agtaaagtga acctgtaaaa gataagccgc gcaaatattc 2953921 aataaaatct tcatgatacc cgagttcatc ctgtaaataa ctcaaatcgc tatccgtaaa 2953981 cttgaaattt tccaagtatt caatggcttt ttccaagccc gcaaatacgg catagccatt 2954041 ttcaaacgga agccttctga aaaacagctc aaaaatcgct ttcttttcat gaatgccgtc 2954101 tctccagtac gtttccgcca tattgatctg ataaaggtct gtatgtaatg acaggctgtc 2954161 atctttaaat ccgtactcta acactgtttt tccccttcct tactctgcca cttgcgctcc 2954221 gatgctgttt gcaaaatggg aaagagccca tgcgtgcccc tcctgattaa agctggcaac 2954281 agcttgttta tgcacaacaa tccgaaaacc tttgttgtat gcgtcaacag ctgtatgcaa 2954341 cacacaaata tctgtgcaga caccggcaag atgcagttcg ccaatctgcc gctctctgag 2954401 tttgagctct aaatcagttc ccgcaaaagc agaatatctc gttttttcca tgtagtaaac 2954461 attaggttca tgttcatgtt tctgatatag aggcaaaagc tttccgtaca gatcttttcc 2954521 ttccgtgcct tttatattat gcggaggaaa aagacgggtt tcagggtgat attgatcccc 2954581 ttcatcatga gaatctactg ctaatacgac gtaatcaccg tttgtgatga attctttagt 2954641 taaattgacg atcgcctctt caatcattct gccgggctcc ccgcaggtca attttccgtc 2954701 actcgccaca aaatcattcg tataatcaat acaaataagt gcttttttca tagccggcct 2954761 ccccgccatc agtatgagaa cattatatct tatctccagt tgtaagtgaa ttgccatgaa 2954821 caaaaagaca aacggtccgt ttgtctctta cgatttcagt actgaccgat tataaatgtc 2954881 gtcctgaata tatatcaatt cacgattcac agcgatatca gccgcaatga cgatgcctaa 2954941 gggcgtatga aactggagat cagatacaat cttgaaaggc actccgtacc ggctcgccat 2955001 ttggatataa gaagagtaag actgatactg aagctctcca ttaatcaaaa gggtgacgtt 2955061 atggctgttt ttcagctcgt gctctgcctc tttatacggt ttgcttctaa gcacctgtcc 2955121 tttcgtcagt gccaaaacga ctctttctct taaagagcct aaaaacaaat ggcgctcgtc 2955181 aggctttgtc tccaaaggcc catacattcc ttgctgcaaa tagagatcca ttttatcttc 2955241 actcaaaagc ctgtcctccc gtcttgtttg tcttcattat cacctgatca ggcaggagct 2955301 aaactttcaa gcgccgttta catttctgtt acccaatgaa tgattttttt ggccagctca 2955361 ccagcagggg tttcctctgt atgccggcgc aacgacgctt ccagccgttc aggcagagtt 2955421 gctttatctt cttcatagga aatgatcgtg ctccactcca gctgcggtac cgctacaagc 2955481 gtgcgcagtt cttttctgtt ttcatgcaga tacacgtccg tgatcattcc ggtttgcgta 2955541 ttgatatttg cttttctgat tttcataaca tgacctctct attcaaagac tacccatatt 2955601 atacaataaa aaagcaacag cctcttgtga aaaggctgtt acccgttaaa cgaaactgtt 2955661 tcatcagtga tatcggcatc tttgaagaga gttttactcg tttggttgtt aatcttcaca 2955721 aaatcaccaa gctgaaatgt gcctgacccc gcccctgaat gagcgacgct tttgggcgaa 2955781 atcgcaaata cgtctccaaa gcttgccgcg gcattatccg taactgacat gatataaatc 2955841 ggccccacaa ttgcaggcat ttccccacct ccgcattgat ttacagcatc atatgcaagg 2955901 agccgataat ggtgcccgcc tattcagctg gctttgcgtt ttcctcgagt cgtgaccgct 2955961 ggcgcagctt gatcaagcgg acaatattca ggaagaacgc cttcactacc gcataaaccg 2956021 gcaccgctaa aatcatgccg agaattccgc cgaagcttcc cgctccgatt aatagcaaaa 2956081 taatcgtaag cggatgggta ttcagccgct ttccgatcac aagaggagac agcaggtttc 2956141 cgtccagctg ctgaacgatg acgaccacaa taatcgcaaa cagcgctttg gccggcgagt 2956201 ccataaaacc gacaatgaca gccggcgcgg caccgagaaa aggcccgaca tagggaatga 2956261 tattggtaat cgccatgaca atcccaagaa tcagggcata cggcagtccg gcaattaaat 2956321 agccgataaa acacgctgtt ccgacaaaaa gacagattaa cagctgcccc tggaaatatg 2956381 ccgcaagcgt atcggataaa tctttaaaaa tctttaagcc ttctgtccga taagaagccg 2956441 gtagaatttt tactgccaaa tgcggaaagc ggtgtccgtc tttcagcatg taaaaaagga 2956501 taaatggaac agtaataata acaagcgtga tgtttgtcac gacaccaaac accgcagata 2956561 aactggacgt gatattttgc ggcaggtttt ggagaaaact tgtcaatgac tgttcaattt 2956621 ttgatatcga tacataatcc tggttcatca tccaggtaaa ccattgagaa tgggacaaat 2956681 cctttgtcag cgcctgaatc tgttttatat aatcaggaag gttgttaaac agccctgtca 2956741 cctgtgcggt gatgataggt ccgactgacg ctgaaataaa ggcaagcaaa ccgataaaca 2956801 gtaaatagat caatagaatg gataatgtcc gcggaatttt tttctcaagc aggcggacga 2956861 ccggattaaa tatgaaatac aaaattcccg caattagcat cgggaaaaac aatgtcgaga 2956921 taaaaacaat aaacggctga aatacaaatg aaacttttgt tgctacaaaa ataatcagca 2956981 aaacaaataa aatctgcaat gtccaaaaat ggacttttga tttcaacaag ctttgttcct 2957041 cctagttttt ctttgtctgt cagataaaag aacttatacc ccatcattgt aacaaaaatg 2957101 aactcatatc agaactctta atataatgaa aggagtgttg gtgatgaagg ccgtgacata 2957161 cgatacagat tcagaactgg cttatatcta tgttcttcct ccgaaaaaga acaggaatgt 2957221 acggactgag gagctcagag tcaatgattg tctcctgctg gatatcagcc aagatggcaa 2957281 aatcgccgga ttcgaatgtt ttggtgaggc agcacacctc tgtgccccat ttgccgggaa 2957341 atcccggctg tatgtaaaag attcagacgg ttatcatttt cgggtctgcc agcatgcttc 2957401 agtccgttcc tgctatacgg tgtaccgtgt cactttctgt ttttcagatg gtgactatca 2957461 ggaatttgcc ggctttgacc ttgatggaac aatgtatcat agtgcgtttt tacagcgctt 2957521 aactgaaaaa taggacgtcc tgttgtacgc ctatttttca tgcgcaagca ctgttagacc 2957581 cgctcactgt aatctggggt gacggaaatc atgtgctgga ttctgatcaa acaaacagaa 2957641 tttcgggctc cttcaattgt gatatggtca ggttttacat cgatcagtct gcctctgacc 2957701 gtatctcgta ctgtctgtat aacgaacctt gagccgatga gctttttaat ggtctgatag 2957761 acataaggat cgactaaaga gaccagttgc ggactacctt ggttgaccat acttttatcc 2957821 cctttgtgtg ttttatctca gcttatgccg cgcttatgga taatgacaca ggcttacctg 2957881 ataaaacaaa ggggtgcgga gattttagga gaatacgttt ggaggcgggt gtaaaggaag 2957941 tatcgatgaa gcggagacag cgaagaaagc tggcgctgtt ccgtacttat acaggcttta 2958001 tcacggatgc ctgggcttgg tcgattaatt ggtccagctt ttctattttt tttcgtgcgg 2958061 ttgaaggatc aatttggcgg taatgatggt ggccgcccgg ctcttcatcc agttcgtccg 2958121 cttttttgac aatctgctgc agtgtgtttt tatctaattc gccttcaggc aaataggaat 2958181 ctgtatgaag caaaatggct agtgcaatct cttttgctgc tttcggttcc tcgccaagcc 2958241 gaatcagaag tttatgcgcc cgttccgccc ctttaatggc atgaatgtca tttcttttgt 2958301 atttctcata atcccacttt ccgtctgtat accattcata atggccaatg tcatgaagca 2958361 gtgccgcttt tgctgctaaa tcaggattaa tgtcagcctt cacagacagc ctgtatgcat 2958421 gataagcgca ggcaatcgca tgtgccacgc cggaacgctg aagatatttt tgtgcaattg 2958481 gatgggtgaa aacatccatt aatgtaacct ttctcatgga aacccctcct ttagatattt 2958541 ttagaatcct aacataattt gcagagaaac tcaattctta tgtcacatca ttttgatctt 2958601 cttatcatca ttgttatacc ctaaaagcaa cgtttcagtc agtatatgcg gctgttcaat 2958661 aaaatgcgct ggctgcagcc ttttgtataa aaaaaagagc agaaaatatc tgctctacaa 2958721 aaactcttta atatcataaa tgcggccgtt ttccgtccct ttttctagta aagaaagcag 2958781 cgtgccggca ataaagtccg gactgcgaag gcttcctgtt tcatttaatt tccggaatcg 2958841 ttcaatgtgg tggaaatcct ttttcgatga agaacggatg acggcctgca tctcagtgtc 2958901 catcactcca ggtgagaacg aaatcatgtt caccggcagc tcttcatcct cctgttcaaa 2958961 tccgaatgtc ctcgtaaaca tgtcgagccc ggcttttgaa ctgcaatacg cgctccatcc 2959021 cttatatgga tttttggcgg ctcctgaagt aatgttgaca accgtctttt tgccgctgta 2959081 tgaagcaaac cgttttgtaa acagctgact caaaagcacg ggcgcagtca ggttcagctg 2959141 ataatggcgc tgaagctcgt caagagacgc ttcgccggca cgtttgatcg gcgttaccat 2959201 tccggcgtta ttaataaggg taataccaga ataacgatct gaatcgatgg atgagagcaa 2959261 tgtttcaaat tgctgttcag cttcttcgag attgatgagg tctatttgat gctgcgttag 2959321 ttttttgtga gagacatctg ttttcgttct ggataaggca tggacttcat gccccttttc 2959381 taaagcctgt aatgcaatgg cttgacccag cccttttgac gctccggtga tgatataaag 2959441 ttccattgga aacctccttt tccgttatta ttgtacggca cctcttttac acaacacaag 2959501 cacgcggcct acgccttctt gttttcctgc gctgtgactt ttgggatgag gaacacgatg 2959561 cctgcaattc cgagcaggat cagtacgaca tagatcatcg gcagcagcaa tgatgatgtt 2959621 tcttgttcat cttctgtttc cgttgatgat gtctttgtca ttggtttttc agcaaaagta 2959681 attccaagct gtttcgactg ggccgcaatc gtgttggaat cctcggcatt tgttgatgta 2959741 aacaaatctt ttatcagctc ggcgtccttg tccttcggtt tatcaaaagt gatatccttt 2959801 tgttcctcag gcagttctgt tttttcttca tagtaggtat cttcatgcaa ataattcgta 2959861 tcgatttcga tgtctttttt ctcatactgg tttggcgcga catctgtatt ttcttcagtt 2959921 tgggcagccg ctgcagaggg tatgaaaagg gaaaaggaga gcatacaaat catgatcccc 2959981 ttttccatgc tgcgatcacg cttcatacgt ttcatcgctt tctgctgtgt gttcagccat 2960041 caaccggata atcagcggca gagccacggc aatcaccgta atgatcagca gaactgttat 2960101 tcccattgta aacaagtgcc cagtaccgta ctggatgtcg atatatactt tcgaaaccgg 2960161 atcttcaaat gtaaagttcg gcatgatcaa atcaataagc ggtgcgacat agaataggat 2960221 cattgctgct gaagcaaccc agccagggat tgatccgaat ctgaatgccg tccggatgaa 2960281 ggcagagctt gcgaccagca atagaatcgt aaacaccgac cacttaatcg tctgatcgtc 2960341 cggcagtgaa taaatattca agccgaacaa gctgatcata agtccgacaa ggatattcag 2960401 aattccgaat aacgctcctt tgacgagaag cggtgcgttt tggtaatacg agctgaaata 2960461 gccgattaac agactgctga tcaacacaat gacaaggatg acaaccggag gtaccgtctg 2960521 aattttttct tccggaacct ctccgctgat tttaagcgga ttcgctaagt aatcatatac 2960581 atagccattg ttttgcccgt ctactaatgt atttccgagt atgccgtata cgtcatttcg 2960641 cacgagtttc gtggaggcga catttttccc ccagttgttg tttaaggtgt cggctttcgc 2960701 ttgaacatca ttaacgcttt gctgcatgtt ggttgtgtaa tcaatgatgc cggactggcg 2960761 atcagacaat gaacccatca tgtctgacat ttgcagcact tcctggccga ccgtatcttg 2960821 gacactcagt gccatggtac cagacagccc atcgttgctg aacgtcgcag attcctgtgt 2960881 tgcgcccgtt acaagctgtt ctgacgcttt tgcggcactt tcagagattt tcgtcagttc 2960941 gtcgagaaca cctgcttgag agtcacggat atagccgctg tagtcgtccg caaatttggt 2961001 catgccgtcg atgaagctgt taatatcctc atctgtttgc atcgtgttgt ttttgagagc 2961061 ttcccagctg gctgattctt caggtgtgag agccaggact gattggacgt tgccatcttg 2961121 ctcttggatg acttcacctt taataatagt caaagagcct agatccagat tatcatttag 2961181 cgtagactta tataaattta aagagttgta atacttcatc aagttagaaa tattatcagt 2961241 ttcaattcta cttgaaaaaa ttgaacttag tttttctttc tgatctatat agcctctact 2961301 ctgcaaagtt tgtattattt cgtcttccaa attgtatatt aacctataag catcattgac 2961361 attattatca aaatcaacca acttttttgt taagtcacca atttgatcat ttaattttga 2961421 aactgtttta tttaactctt taatttcttg atttaactca tcaatatgtt tctctagttt 2961481 gttgttatgt tcctcttgtt tttcttgaag tgcattttct atttcctcta attttatcgc 2961541 tgcttcgttc agacgttttt ttgcacctga aatatcagtt tcaccgtcag ctccgtcacc 2961601 ctgtagccca tcactttgat ttgagccatc gttttcatct gcgagttcaa tcaaagagaa 2961661 atctgtttta gaggttcctg tattctccgt gtttgtatct tgttcaggaa cgttttttga 2961721 agattcttga tgtttttgtc ccgtttcaat gttagtttga acatcatttt gtgatccatt 2961781 atcttgagta ccctcttctg atgagccagt atcttcattt gttggctgat catcggatgt 2961841 tggaatatca ttcgacggtt cttcagtatt aggagaatca tcggttgatg gttcttcagc 2961901 atcgggtgtt gttggttttt cttgttcagg ttcttttaac ccttcagaga tatctttaat 2961961 ttcagttgca acatttttga gctcatcccg ctgcttctct aaatccaatt ttatatcttc 2962021 aatatcttcc ttatctgtgt catctttatt atcagatgtg tcttctccat cttccttttc 2962081 gtcgctttcc ttaggtttaa gtaaactaag gcggttcttc ccgatattct cttgcaattg 2962141 atttaaattt tgatatttaa tagcttcata ttgactttta tatcgagata gaaatgcatt 2962201 aaacatgtca ttctcaattt ttttcatacc catttcttgc aatggcactt gattttgcct 2962261 taacttttca gcattgttca acgcaaggtt tgtcagtcct atttgtgtct tcgcttggcc 2962321 gatcccggtt gccaatccgc tcatgcgttc gctgaactga ttcgcctttt gctgtgcctg 2962381 gatggcatcc agacctgtcc ggatttgctg ctgtgttgaa tcctgggctg ccaaaagcag 2962441 ctttttctga ttctcttgat attctttgta cctttcaact gtatcaatga attctttcag 2962501 cgtgtttttg gcttcctccg ccgtagaagc tttttctttt gtcgtgcctt gcgcttcatt 2962561 cattgatttc ttcagctcat cgattaagtc tttttgctgt ttgatttcac ctgctaaatc 2962621 attagagctt ggtttgtaaa agttgtacat gacattctgg aattcagatt ctttattgac 2962681 gatcttgtca aattctcctc tgatgttgtc cactttttgc gaaacaaaat tccagtataa 2962741 ggccgacatt tttttgttca ttgtcttttg ggcatcctca agctcacgct gaactttttc 2962801 tttgttaacc gcattcaggt tatcttgaat gctgaattcg agcgttgcct tttgaggatg 2962861 gtctttgtca tagctcaaaa tgttttttga gaagtctgag ggaatgtaga caatcgcatc 2962921 gtatttcttt gaagcgagac cggtctcggc cgcgcttcgg tttacgaccg tccacgaata 2962981 atcaggacgt tcacccagaa cggccgctac ttccttgccg aactgggcgg atttgtcctc 2963041 ttcatcagac tttacctcat cactcaatac gcctgtgtct tcattcacca ccgcgatttg 2963101 ccgggtagaa ttgactgctt ttttcgttgg gtcgtctccg ataaatcgga aaaacaacac 2963161 cggcagcagc aaaatgatga tgacggcgga tattaacttg atcaagcttt ttcgttgttc 2963221 tgtcatctag cactctccct ttcagcagaa cataaaggaa tttgaacttt ttgctccttc 2963281 ccgttttcca caacatatcc gaagcccggc tgaatctcag gctcctgtct ttggtacggg 2963341 agaggaatga cattttgctc agactttttc atcagcagaa tcgcgtggcg gatttgcttc 2963401 atctcagtcg tcaaggagtc atagcctttt gagaattcgc tgtggtttcc gcccgggata 2963461 aagctgaacc caagatgagc gtatgatttc atgaagttag cgagacgatc ttgtattctc 2963521 gtatcaatcg tctgctggaa tctcgttatc ccgtcaatca tcagcacgac ttgtgagaat 2963581 cgcagatttt gtgcgtctcc ttggcggacg gcttctacat acatggcttc tcttgttttg 2963641 aaaatgtctt ctgctgtttc aatccactgc tcaatatctt ctttcgtttc caaatatgaa 2963701 acatctgatt ccttcgcata atgagataag ccgcggtcaa tcgagtcaaa caggccgatc 2963761 atttcggttt catcatcaat cagatgttca agcatgactt ttaggacgtt tgttttcccg 2963821 cgctgagttt ggcctaaaat caggcagtgc ttatgcttgc ccaaatcaaa atagactggg 2963881 ctgactgttt cttcatgaag cccgatcggt acagataaag gcttgcgttc cagcttgaag 2963941 cggatagaca attctctcgt cgacaagctc tcaggcagca tcggaatcgg tgccggctgc 2964001 tccattgaag caaatcgccc ttgaagtttc tgtacgtctg atttcagctc gttgaacatg 2964061 ccgatatcat catcggcgtc aacaggcagg aacatttgcg cgaaataaag ctcttccttt 2964121 tgaatgatga cgcgtcccgg aatcggctca agattgaatt tcggacggcc gtaaatggaa 2964181 tatccttctg attgatccat gagataatgg acaatctttg ttttcaagtt atttaacaat 2964241 gactggcgga cagcattcac ccgcgttgct gtcagcataa agtagatacc caagctttgt 2964301 ccgtctctgg aaagctggac aaattccgat tcaagctcat gcatctcatc cttgacaatg 2964361 tcaaagttgt caatggtgat aaaaatgaat ggaagctctt cttcgctcag cgcattgtac 2964421 attttgatgt ggctgatttc tttttcccgg aacaaacgtt tacggcggtc aatttcttct 2964481 ttgatgcgaa tcatgaactt ttcaattttc cttgactggt ccatcaggaa gtaatccgcg 2964541 gtatgcggga gcttcgctaa tggcagcagc gttccgtttc cgaaatcaaa gatatagaca 2964601 tgaagctctt caggtgtgta tacgtccgca aaactcatca ggaacgttgc ggctgcaatc 2964661 gattttccgt agcccgaaga gccgaagatg ccgatatttc catcttccat catcttataa 2964721 gcaattggcg cctgtctttg cagatcaggt tcatcgacat acgcaaagtg gaaatggtct 2964781 ttttcgtttg aagggaaaag agtgcgcgga atacgttccg caagcggcgg cagccaaggg 2964841 cttggcagct tctcgattcc catttcatct tggatgcgtt caatttcgtc aactacagct 2964901 tcgatttcgg tttgaacgtc ttttttcgcg ttatcttcgg tatcaacctc agaaagcggg 2964961 atcagacccg tatctgtgac gatcgcgatt tcatcctcgg taccgtagac ttcctctaag 2965021 taaggcgccc cgctccatgc agattggaac agctcataca cttcattgtt tccgacctgc 2965081 aaatagccgc ggcctgttac ggtaatgttt gcggcatcgc tgtttttcaa aatttcttta 2965141 ctgtcggtgg catcctggac cttgagcgct actttaaagc gcgagttact ccagatctgg 2965201 tcgtcgatga tgccgcctgg cttctgtgtc gccaaaatca aatgaacgcc gaggcttcgt 2965261 ccgatacgcg cggcactgac aagctccctg ataaaatcag gctcctcgct tttcagctcg 2965321 gcaaactcat cagaaattaa gaacaagtga ggcatcgcca cttctgcttt cccttgcttg 2965381 tatagctttg tatagtcatt gatgtgattg acttgatact ggtcaaacag gcgctgcctt 2965441 ttttttagct cgcttttaat ggaagcaagc gcacgcatac tgaagttttt gcttccttca 2965501 atatttgtga tcgtgccgag gaggtgggga atgttacgga acggctgcgc cattcctccg 2965561 cctttatagt caattagtaa gaaagccgct tcatgcggat gaaaatgcac tgcaagtgac 2965621 aagatgtagg tctggagaaa ttcacttttc cctgatcccg ttgtccccgc aagcaagccg 2965681 tgcggaccgt gtgctttttc gtgaaggttc agatacacaa tgtcatcttt ccctttatag 2965741 ccgatcggca ctgacagcga cttcgacgat tcacttgtca gccatctttg ctgaatgccg 2965801 atttctttta cttccttcgc atgaaaaagc tccaggaacg ataccgtttc cggaatggaa 2965861 ttcgtaatgc cgacctggtg gttcagcgtc cgcagtgtgc gtgaaaaccg ttcgttatcc 2965921 tcacgctgat gatgatcgag acggaacgga attcttaccg cttttttctt ttgtattaaa 2965981 atgtcgcctt catgctcatt aatgtagcgg acaagagttg taatgttttc cgacaagctt 2966041 tcctttgttt ctgcagcgac aattgtcgag atgcccagat gctcatgctg cccttctaaa 2966101 tattcgagaa tgacatgctc agagatcagc tgctgattcg tgatgacaaa tacaaaatgc 2966161 ggtttgaact gcagtttttc tttgtcatct tcgagatcac gctctctgat caattcgtaa 2966221 agtgaagaca ggagctgatc tcgggtttgc tcattataaa taaatccttt tgcataaata 2966281 tggggcattt gaaattgcgg aagccacttc atccactccc agtctttata ctcttcttca 2966341 tgaaaaataa atacgaaacg caaatcgtga tagctgttaa agaacgacag ctgtccgatt 2966401 agctggtgaa tctcattttt cacaatttgt gatttaccga caagccccat cggaccttct 2966461 gccaaatcga ccgtcaccgg cgcattacgg atatctttat agacgcgttg catgtgctgc 2966521 gatttctcca tgaggtcatc gatatcacga ttcgccaagt ctccgccact catattgatt 2966581 tcatagcttg acggaactgt tcccgtccca agccgcagct ggagataatc cttgctttca 2966641 agtgattttt cccagatccg gtcactgatt tcacttgtta agtatttcat ttgttcaaat 2966701 gaaggaaagt gaaattcaag aacctgcttt tgcttttcag caagtgcctg aagctctttc 2966761 cgcttattgt ctaagtaaag cttatataca cgctcccgtt tttcctcgcg ttttttccgc 2966821 tggtttttat cacggaaata ttgcactgtc gaggtaatga gagtcatcat aaacatcgcc 2966881 aaagaaacga gtataaatat gccgcgcggc tggatgatgg caactacgcc catcacgatc 2966941 agcatcacaa gcggaggcag gatgacgagc cacagccctc tgttggtttg atcgctctcc 2967001 tgagagggaa aactgaaaga aacgcggtca tccggcagat cgtataccat ccgcggcgtt 2967061 cttctgtact gcggatattt tttctgcatc tctgtactcg gtttgaccgt ttctgttaac 2967121 gctgtttcaa actgggcata atgaacaatt tctaaaaggt cttgttccgt caccctcatt 2967181 tgcgtgaagt tccagaatat ttcatccccc ggcttgagcg gcgtattggc gttgattttc 2967241 tctccgttca agaagatcgt tccgctttca gggcggaccg accagctgcc gcctgcacgg 2967301 agcaaagaaa acgtgctttg ttctgcaaat gcaaaatctt gcggattcag ataaatatct 2967361 gcattcgttt tttctgagga acatacaatt tcatcccgat ttcccgtaaa ataaacggat 2967421 ttctcaggtt cactgcccgt caatatcaag cgtatatcct gctgatccgt ttggagagta 2967481 aatgatatat ccgtctcaat cgtgccgaga caatcatttc ccaggaaaac ttcgtattgg 2967541 ccgccggatt cctttctttt aagagaaatc actccgctat taaatggaat ggtgctgatc 2967601 gtaacagaat ccttcacatc aggccctatg gtcaccggat gagacgacgg gaggttagac 2967661 agatttaatt tttgaacgtt attttggtaa aaaacccata atagactcaa atggcgaacc 2967721 cccttacggc cgaatggcag catgcgatga cctgcgcttc atgtctcacg ttatttgtca 2967781 tcttttttct catctttctt ttctgtttct tttttctcgt cttctttttc cttctgttct 2967841 tcttttttcg ctttttcctc ggctgcggct ttttcttctg ccgctttctc ttctgcttgt 2967901 ttttcttcgt ctgtttgtgt ctgttcttcg cttgtatcga ctaacgatgt ttcagaatta 2967961 gactgtttat tttcttgacg ttctttttgg gctttttcaa gctcactatt tactgaatca 2968021 agttcttttt gtatgtcttc atcatttgta tcctcagata aaagctgctg tttatattta 2968081 gctagggcaa agtaaatata atcattgtat tccagcttac ggccgatact gatcgcttct 2968141 ttgtattctc ctcgaccata atcaatccaa tataagaaat gctgagggtc tgattgaagg 2968201 gtgactaaat tattttctat atttttggtt tttgcactcc ccaggttttc gacctcaaca 2968261 taggacgtcg ccagctgata ctgcaccgat tcaggcaggc tttccgcatc gtacttggac 2968321 agtgtgctga tgacttcact gtactgcttg tttaagaacg cacggttgct gtccactatc 2968381 gcctggtgct ttggctgcgc gaaaaataag gcgtacatcg aataaataag tgccggtaca 2968441 agcaaaacaa tgagccccag gccgatatat cgctggatgt tccacttctt tctcgggata 2968501 tgtatgtatg tttttgcttt ggcttcgagc tcatcaatat gggtttgaat cagctcgagc 2968561 aaatcatcat aggattcagc atctaatatc gcctttgcct ctgcggagaa cgtcagcgtt 2968621 tcattgaatt tcaggtagtc ttcaaacgca aaagcgccgt caactgccaa agccgctgcc 2968681 gctttcagct cctgccatac tctttcctca tcacgctcgt aaggaggaat gctttctttt 2968741 actccataat ggagaaaata aggcgtaagc cctttatcga atacaatgtt ttcaggagcg 2968801 acaatcaaat tcagcctcga cagattgtgc tgctgtacgg cttgaacaag ctgataggca 2968861 aactgccatt tacttttttt atccttagct ttcatgaagc ggaatgcttt ataggaggag 2968921 ggaggttgga ttgtgatgat tacttcatca tccgtcacat cgatttcttt atgaaaaaat 2968981 ggatttatat ctttgatcac gttagcttca agaccgtcga gaagctttat tttttcccgt 2969041 tgaaaggtaa atgtatagcc ggcatctgtt ttctcggcaa cagcttctaa ttggttttct 2969101 aaatatgatt tttgttcacc tgacattcaa ccagatcctt tcataatatt tcaagccggt 2969161 ctccgtttgt aatgccgcaa tcagacagct tgcattctcc ggaaaacacc ttatccttgt 2969221 tcaccactct gatccagtgc ccttcgcgcg gaggcataga tacgctttgg gcctgccaag 2969281 caatatcaat tacttttttc accgggtggt aatctgacaa tctgagatca aagacactgc 2969341 cgttataatg tttcaaatct attgtaatat caatatacat ttaggatcac ccttacatag 2969401 aaagagcgcc gtcttctttt gaatcaggcg ctccttccct ttcatactgt tatccgcgga 2969461 tttgatttgc gatgtcttgg tcagtagact caagtgtatt tgctgtttga tcaagctgct 2969521 gattcacatc ttgaagcaaa tctgacattt tgataaatga aggtttgagc tgctcgtatt 2969581 gatctgcgaa cgcttcgctt gaagcacctt cccacatgct tttcaaatca gagatcattc 2969641 ggtttaaacg atcaacctga tttaatactt cttggctttc aacgccgtat tgcttcgcca 2969701 tcgctcttag ctcttcgggt gtgacacgaa ttaatcctgc catattcctc attacctcct 2969761 gtgccatcag cctaaatatg ggctaattca cttattttta gaacgtcatt attataaaaa 2969821 cagtttttcg gcatagtcaa acaaatatgt tttaatttta caaaatgagt ccaatggttt 2969881 accccgaatc actcaaaaat gacatatact gtaaagtaaa taggtttatt ttcttaatct 2969941 tctcttcatt ctccgaataa tccaaaagac ccaaataact ctccaactcc caaaaaaaac 2970001 ctttcagaaa atttgatgct acagcaccat ttctgaaagg ttcagttttt tctttcctta 2970061 attagtcttg cctccgatga ctttcttaga agattaatag gataagctgt cgtattatat 2970121 gagacataca ctgtcctgca aaaaggcgat tacaccgcca aatgtatata gaacgtttct 2970181 ctcatgaaat tgtttttttg cttctgttct ttgttgttga ttttcacaaa caacaacaat 2970241 cataataaaa ggaaggggat gagatgtcaa agagaaatca agcacgaaaa gtagggagat 2970301 ttatgaccat gccgaatgat ccgtttaaat atagttttga cagacttgaa gatgtggctg 2970361 atcatatcag cgacgttctg cggtgcccga tcaccataga ggatgttaac cacaagctgc 2970421 ttgcctacag tacacacagc gactgcacag accctgcccg gacgtctacc attattggca 2970481 gaagggtacc ggagaaggtg attaacaagc tgtggaaaga cgggacaatt cctgctctct 2970541 taaaaacgga ccagccgatc agagtcaagc aaatcgatga agtcgggctg agcaatcgcg 2970601 tcgctatttc gatttggaaa aacaagcaag tacttggctt catatgggcg cttgagatcc 2970661 aaaaaacatt gtccgatgaa gatctgctga cattgcaaat ggcagcaaaa gcagtgaaaa 2970721 acaagcttct caaacttcaa atcagaaaaa cgaaaaatga agaacgcagc caagaatttt 2970781 tctggaaaat gctgaccgga cacatccatc aggaggatga tatggcggat gggttccata 2970841 agcttggaat ggccgctcct tcagagtttt ccgttatgat catccgcata aatggcgagc 2970901 tgactgaaaa aatcgaacag cagctgcaat atttacagga aacgacccag caggtttacg 2970961 tgctgctggc gaccgtagat tccaatgaac ttattatatt aacctcaccc aaaacagatc 2971021 atccttttca agatttaaaa cagtttgctt taagtacgca aaaacagctg aaggagcggt 2971081 ataaaataga agacgtttct atcgcttttg gcggaatata caactctatt tcttttgtct 2971141 cccgctccta tcaggaagca ttgtccgtct taaaaacgaa ggaacggttc gctgaagaga 2971201 ccaaacatct tttcagcttt tctgagttag gcatttatca atacttagat gtcttaaatg 2971261 aaaaacggaa acaggcgggc cattataatt actcgctttc caaactggaa caatatgacc 2971321 gggatcacca gtcaaatatg gtagagacgc tagagcgctt tattgaagcg gacagcaacg 2971381 tgaataccgc ttccaagctg ttaaatatac acgttaatac gttgaattac cgactcaagc 2971441 ggatcagcca gatcgctgaa attgatttga aaaatgtgaa tcaaaaattc accatctatt 2971501 tagatatcaa acttcggcac atggatttgt gaaatttcac aaatccatgt ttttttattt 2971561 tcttaatcaa acaaagaatt ttccaaaata tcaagctaca ctaaaaatat cacatataca 2971621 ggaggagaca gatatgatca taggggttcc taaagagata aaaaacaatg aaaaccgtgt 2971681 cgcattaaca cccgggggcg tttctcagct catttcaaac ggccaccggg tgctggttga 2971741 aacaggcgcg ggccttggaa gcggatttga aaatgaagcc tatgagtcag caggagcgga 2971801 aatcattgct gatccgaagc aggtctggga cgccgaaatg gtcatgaaag taaaagaacc 2971861 gctgccggaa gaatatgttt attttcgcaa aggacttgtg ctgtttacgt accttcattt 2971921 agcagctgag cctgagcttg cacaggcctt gaaggataaa ggagtaactg ccatcgcata 2971981 tgaaacggtc agtgaaggcc ggacattgcc tcttctgacg ccaatgtcag aggttgcggg 2972041 cagaatggca gcgcaaatcg gcgctcaatt cttagaaaag cctaaaggcg gaaaaggcat 2972101 tctgcttgcc ggggtgcctg gcgtttcccg cggaaaagta acaattatcg gaggaggcgt 2972161 tgtcgggaca aacgcggcga aaatggctgt cggcctcggt gcagatgtga cgatcattga 2972221 cttaaacgca gaccgcttgc gccagcttga tgacatcttc ggccatcaga ttaaaacgtt 2972281 aatttctaat ccggtcaata ttgctgatgc tgtggcggaa gcggatctcc tcatttgcgc 2972341 ggtattaatt ccgggtgcta aagctccgac tcttgtcact gaggaaatgg taaaacaaat 2972401 gaaacccggt tcagttattg ttgatgtagc gatcgaccaa ggcggcatcg tcgaaactgt 2972461 cgaccatatc acaacacatg atcagccaac atatgaaaaa cacggggttg tgcattatgc 2972521 tgtagcgaac atgccaggcg cagtccctcg tacatcaaca atcgccctga ctaacgttac 2972581 tgttccatac gcgctgcaaa tcgcgaacaa aggggcagta aaagcgctcg cagacaatac 2972641 ggcactgaga gcgggtttaa acaccgcaaa cggacacgtg acctatgaag ctgtagcaag 2972701 agatctaggc tatgagtatg ttcctgccga gaaagcttta caggatgaat catctgtggc 2972761 gggtgcttaa ttcacaataa gcttgcagaa agatttctgc aggctttttt attttttaaa 2972821 aggaaaaaag agaccatttc acgaattatg actatgaagt tgatcataaa ggaggattca 2972881 tatggctgtt cagcaatatg gcgtgttaaa aggcatagta ttagacatga agcgggaaac 2972941 agatgatgac agtcctcatt tccaagtcaa aatgctcggt gaagagaata cgtattacag 2973001 gtgcgccatc aatgtgatgt ccagttctga ggaatctgaa gtattgtatt tggctgacga 2973061 tcagtttgat tcgggctcaa ttaccatcct tccgaacatg ccgtatggat atacaaggat 2973121 caatgaagca aaccgtgaag tggcactgga ttatgtgcgg ggcaatttgt ttgacccgcg 2973181 ggaaatgaag cctttgcctc atgaaatcac gggacctgat aatgatttaa atgattttat 2973241 tgaaacctat atgaagaaag cacaagatga gaaaacgccg gtttatatat tcggttcaaa 2973301 attcggccct gaacaggctg cagataaaat attcggcttt accccgacta acggaatgca 2973361 caatatccat atgaatcaag ggaatgcaat ggatacccgc tggaaaaaag acaacggctc 2973421 ttggcatgac gggggtattc tgattcagtt tgcagatcag tgggccgctg tgtttttagc 2973481 gtttttatcc caatcttggt gtaccgatga aaacggaaac cctgtcagag attgtgatca 2973541 tacccaaacg tctgcgtaag atagaaaaag agactgcggc aagcagtctc tttttgataa 2973601 gattacacat tttcaacagt ctttaggctg tttggcctca tatcgctcca atgcgattgg 2973661 atatagtcca aacaagcttc acgccctttt tgctcatgaa cgactgtcca gccgctcggc 2973721 acatctataa aacccggcca tagggaatat tggccttctt cattgaccag caccaaatat 2973781 gtgccatccg cattttcaaa aggatttgcc attctatttc tcctccctta tttattcaac 2973841 tcttccaatt tgacagcgag aaccttgccg atttgagcca gaggttcagg ctgacataaa 2973901 tctttatgac ggcagtcgat gtcgatttgt tcaatctgtc cgttaatata aggcttccac 2973961 gagtcaggtt caatcgggtc aaaccattca ggaatgattg ttgatctgaa aaacaaaaca 2974021 tttccgcgga aggttttcgg cttataggaa cctaaaatgc cgacagaatt tacatacgta 2974081 ttcttcaaat ttaaaatgac cgtttcatcc aggctcgcaa gcgcactgcc gtcacggcga 2974141 agaatctcaa tcgccgcttc aaaatctagc ggtttttccc ctaagctgtc tggatcatac 2974201 ccgcctaacg ccagaagggc aataagcgct tcctcatcat ccggtgcctc ttttatagga 2974261 aggaagtggt tcggataggc gtccagcatc accaacaggg atacttcttc tccttgattt 2974321 tgcagctggg tagccatcgc ttgaacgaca ttcccgccca gggaccagcc cagcagatgg 2974381 tacgggcctt ttggctggac cgttcggatt tgtttaatgt aatcggcagc catgtcatca 2974441 agtgttttcg gaagctcctc gcgctgcccg attccccgtg cctgcaagcc gtagatcgga 2974501 taatctgttc ctatattggt catcaaaccg gcataacacc agctgagccc ccctgccgga 2974561 tgaacacaga ataaaggagg cttgtctccg cttgttcgga gcggcagcag aacgtcaaga 2974621 gcgctttggc ttgatcccat ttcaagtctt tcagcgagcc cggctacagt aggtgcttcg 2974681 aacaagttgc cgatgctgag ttcaacgccg agcgcttcac gaatgcggct catgagctgt 2974741 acagcaagca aggaatgtcc gcctaaatca aagaaacggt catcaatgcc gacacgcggc 2974801 aagtgaagca cctccataaa gaggtcacag agaatttctt cctgcggcgt tctcggtcct 2974861 cgtcctgtca ctgccgctgc gaaatccgga gcgggcagcg ctttacgatc aagctttcca 2974921 ttcggtgtca gcggcaattc tttcatcgtc acaaaggcag caggcaccat gtaatccggc 2974981 agtctctcag cagcatatct gcgcagttcc gccgtatcaa atgtttcttc cgaagggatg 2975041 acataagctg ctaaccgttt atctcccggc tgatcctcac gaacgatcac tgccgcatct 2975101 tcaagctgcg gatgctgaac aagcgcggct tcaatttctc ccaattcaat ccggaatccc 2975161 cgaattttca cttgatggtc tgcacggccg acatagtcga gagaaccgtc agcgcggagg 2975221 cgggccacat ccccagtgcg gtacatccgg gtgcctggag gaccgaacgg atcagctatg 2975281 aagcgttcag atgttaaacc aggccggcct agataacctc gtgctaaccc cgctcctgat 2975341 acatacagct ctccggcaac acccggcggg accggctgca ggcgttcatc cagcacgtat 2975401 acaccaagat cgggaatgcc gcagccgatc aagctgtttg cccgtaaagc tgccatgctt 2975461 cggtctaatt cgatatagct cacatgcacc gtcgtttctg taataccata catattgata 2975521 agctgcggtc tattttcagg gtggcggttg taccaatcct ctaaacggct gagttcaagc 2975581 gcttctccgc caaaaatgac atagcgcaga ctgagtgcct gtccgagatc cggctgttcc 2975641 cgttccgcct gcataaactg atagaaagca gacggtgtct ggttcagaac agtcaccccc 2975701 tctttgacaa gcaggcgcag aaacgcttct ggcgatctgc tgacgtggtg aggcacgatt 2975761 acaagacgtc cgccatgcag cagaggaccc cagatctccc acaccgaaaa atcaaacgca 2975821 taggaatgga acatggtcca gatatcacct gagctgaaac ggaaccagtg ctcggtcgct 2975881 gcaaataaac gtgttacatt ttggtgagga atcatcacac cttttggaac acctgttgag 2975941 ccggatgtat aaatgacata tgccgtattc aaaggggaaa gcggctgagt cctatcctta 2976001 ttttttggat tacctgcagg gtacgtgttt agtttctctg ccagctcggg atcatccagc 2976061 acgattttcg gcacgttttc aactggcgga atgtgatttg cagctttagt gttcgtcatg 2976121 ataaacgcag gctgtgcatc ttttagcata aaagcaattc gatcagccgg ataatccgga 2976181 tcaagaggga gataagctgc cccggccttt agcaccgcca ataggccgac agccatttcc 2976241 aacgatcggg gcagtgccaa tgccacaaat tgctccggcc cgacaccttc actaatcatc 2976301 attcgggcaa gccggtttgc tctttcattc agctctgcat agctcagttc ctgattttca 2976361 tatacaacgg caatggcatc aggacgtaaa gcagcctgct tctcaaattg ctctggcaaa 2976421 catgcgtgcg gaatcttttc agatacactt tgccaatcag tcaccatgct gctgtgttcc 2976481 tctggcgcaa gaatatccag atttccgatt tgctcgtcag gatcagactc ggcagcctcc 2976541 aacaggcgca tcaatcggtc agcaagagcc tgagcagttt cccgtttgaa aagatcagtg 2976601 ctgtattcaa gcagtccttc cattccgttt ggtgtcccgt cagcaaggcg atcttcacta 2976661 atttccagcg tcaaatcaaa cttggcagaa ccgacactgt tgattcgcag gctgctctcc 2976721 atatcaggaa gatgcagttc agcgtccggt gtgttttgga acgcaagcat gatttggaat 2976781 aaaggatgcg tcgcacgcga acgagccgga ttgagcacct ctacaagtct ctcaaacggc 2976841 agatcctgat tgtcataggc ggccagattc acttcccgta ctctgtctag aagctcacga 2976901 aagcttgggt caccggacgt atcagttctg agcaccaatg tattaatgaa cagccctaca 2976961 agatcgccca gcgcatcatc attccgtccc gcgatcggac tgccgatcgg aatgtcggtg 2977021 cccgccccga gccttgtcaa taaagcggcg agaccggatt gaagcaccat aaacaggctc 2977081 accctatttg cgcgagccag ctcctgcaat cgcttgtgaa actcgggctc aatacgaaaa 2977141 tgaatcgtat ctccatcatg actcggctca gccggacgtg aataatcggt tggcagttca 2977201 agctgatcag gcaggttttt caaggtttct ttccagaaag caagctgtcc ggcaatcaag 2977261 ctatttggat catcctcgtt tccaagcagt tcttgctgcc aaagcgcata gtctgcatac 2977321 tgcacagcaa gaggcgccca ttcgggagat cgtccgtggc agcgagccgc ataagctgtc 2977381 ccaaggtctc tggtcagcgg tgttaaggac cagccgtccc cgacaatatg atggacgaga 2977441 agaagcagca cgtactcgtc aggaccgatc acaaaaagct cggcacgaaa agcaggttca 2977501 gctgcaagat caaagctgta gcgtacagct tcggcaagcc gatcagaaag ctccttctca 2977561 gcaatttcag taacatgtaa ctcgggacag gctcgatcgg catctaaaat atgctgatag 2977621 gatgtcccct gtgattcagg gaagatcgtc cgaagacttt catgacggca gacgaggtca 2977681 taaagtgccg ctttcagcaa tccttgatcc aactcacctg acaaacggac agcaaccgga 2977741 atattataag taggactcgg tccttccaga caatgcagga accatagccg gcgctgggca 2977801 aatgagagcg ggatcttttc aggccgctca gctctctgca aagcgggaca tgcactctgc 2977861 gccaaatcaa gatgggcagc gagtccggct actgtcggtt cgtcaaagag cttggcgata 2977921 ccaagttcgg ctcccattac ctcgcgaatg cggctcatca gacgggctgc aagaagagaa 2977981 tggcccccaa gctcgaagaa actgtcatcg ataccgacgc gtgccaaacc gagaacctct 2978041 gcaaacaagt cacacaatat ctcttcctga ggagtccgcg gggcccgatc actgacagat 2978101 gtgctgaagt ctggtgccgg cagtgctttc cggtcaagct tgccattagg tgttaacggc 2978161 agctcgtcca tctccacaaa cgccgacggt accatataat caggaagact agcccccata 2978221 taacgacgaa gctctgcagt atcaatagca gcatcagcga ctacataagc cgccaatcgt 2978281 ttgtctcccg gctgatcttc ccgtacgaca accgcggcct gttcaatgtg cgggtgattg 2978341 gcaagcacgg catcaatttc tccaagttca attcggaatc cgcgaatttt gatttgatga 2978401 tccgcccgcc cgatataatc caaagaccca tcggcgcgcc agcgggcctg gtctccggtc 2978461 cgatacatcc gagttcccgg cggtccgtat ggatctgcaa cgaagcgctc cgccgttaaa 2978521 tcaggacgat ggaaataacc tctggccaag ccggttcctg caatataaag ctctccgaca 2978581 acgcccggcg gcaccggctg caatccatta tcaagcacat acacctgcgt gttccaaatc 2978641 ggtttcccaa tcggaggaac gcccttcagc ccttcttcaa gaaaagctgc ggcagaccaa 2978701 atcgttgttt cagtgggacc gtataagttc gtgactgaac aatgaaggtc ttgaagttcc 2978761 tgcaaaagac cgctcggcag cgcctcgcct cctacaagca ctctaagccc ccgaagtttc 2978821 tcaggttcac tcgttaccaa agcgtgccac agtgtcggtg tcgcctgcat aatgttaata 2978881 tcgaaatttt caatcatttg agctaatgcc tgcggctcac ggatcgtttc tttctttgcg 2978941 atcacgattt gcgctccgct aatcagcgga agatataact ccaatgctga aatatcaaaa 2979001 gcgacagtcg tcacagccaa cagcctgtct tcttctccta gagaaaatgc ctcctgcata 2979061 gacagcagaa aattgcttaa gcttttctgt gtcacaacga ctcccttcgg tcttcctgtt 2979121 gatcctgagg tatagatgat atacgcagga tggtcaagcg aaaccgatac atcctgattt 2979181 tccggcgaat agcgttttat aatctcctgt gtaacagcct gatcaagcac aagctcaggt 2979241 acagccaggt catcaggcag actggctgct atttcctcag tcgttatgat gcatgaaggt 2979301 ttcgcatcct ccagcatgta agaaatgcgg tcggctggaa actccggatc aagggggaga 2979361 tacgccgcac cagtcttgag cacaccaagc attgaagcca ccatctcagg ggaacgcggc 2979421 agcgccaaag cgacaaattg ctccggacca atcccttttt cgatcaacag acgcgcgagg 2979481 cggtttgcct cttcattgag ctttcgatag ttgacttgaa tgtcatcaca catgagagcg 2979541 atacgttctg gcgtaagaac tgcctgcttt tcgaacatgt cctgaaggct gaccagcttc 2979601 tcggattttg ccgtctcatt ccatttagaa atgacttttt ctttctcctc tggcaacaga 2979661 agctccattt gcccaatcag catgtcctct ccggcagaag ccgtttgcag cagctgcaaa 2979721 atacgctgct gatgaagctt aatatcagac tcactgtata cctcgggatt cgcatcaaca 2979781 tcaattcgca gcccgctgcc gtctgttctg tcatatacat tgattgatag atcatcaaca 2979841 ggaccggctg aaagattatg cgttgtgccc cggacgccgg caaagtcgag accgtaatca 2979901 aacggcataa gattgatttg agggccaaat aatctatgat tttctcctat caatttcaga 2979961 tcgcgcctaa gctcttcatg gcgatactta tgatgtcgcc gaatactgcg gatttcccgg 2980021 gaaatttgct gaatcagttc agaaaagctc atcgaagagc ttaccgtcag ccggagcggg 2980081 agaaggttca tcaccatagc cggtacattc agtgacgcgg accctatccg acccatcatg 2980141 ggcaggccga gcacaacatc ctcagagccg gtcatacggt gcacataaac agctgacacc 2980201 gcaatcatga cttcatgcca gcttcctgag aaatagcgcg ccgcttcttt taacgcgttt 2980261 acatcagacg gaggcagata tgccgtatga cgaagaaaac tgttagatgt tcttggcgcc 2980321 cgatcagcca agctcacaac ttcaggtgca tctgcaaaac ggtccagcca gaattgacga 2980381 tccttctcat actgctctga tccgcgataa tctgtatcct cctccaaaat ggcctggaga 2980441 gacccaaagg aacggctttt agctgtttgt ccttttataa gggcagtata tgtacttgcc 2980501 acacgctggg ctatcaggga aaaaccgaag ccgtcgatcg ctatatggtg aatgcgctga 2980561 taccaaaaga aacgatcagg cccggcaata aacagagctt cattgaacaa aggggcatac 2980621 cctaaatcaa ccggctttgc taaatcagct ttcatccagt ttaatgctgt tttttccgga 2980681 tcaggctcag agctgacgtc aatgacgtgc agctgtacat ccggagacgg gtttatcatc 2980741 tgccaaggcc cgtccatatt ttcaccgaag cggacatgca gcgattccgc ttccttgatc 2980801 acgtgccgca aagcttcttc aaaaagagca atattgactg gtccattgat ttctatatat 2980861 tccgctgtat tgtagattgg attgtccgga tcaagctgct gagcaaacca tatgccagtt 2980921 tgcgccccgg tcaaagaata ttgaagatct tttgtatcag gcatccgttt gtttaccctc 2980981 cttttataaa taatccgcgt ttggcagcac ttgctggctg cgagttgtga gcaatttctg 2981041 ccattcttcg atcgttgggc gttcagccaa ttccacgaaa gtcacctctg ccccttcacg 2981101 gcgccattgt tccaccaatg tcatgatcct taccgaatca agaccacgat cgagcaaatc 2981161 ctcttgatct gtgatgtctt ccggtgtttc ttgtagaagc tcagcaattt gtttacggat 2981221 attctcacat gtaaacacgt tctttttgcc agtgtttgct gacgtttttt gaacgtctgc 2981281 cggcgcattc tgcagctgat caagaagact gtcagtcatc acggtaaacg cacagcgtcc 2981341 agccgcatat tccagcgcca tttgatgttt ttctaatgaa aaatcagcaa ctgcatctcc 2981401 cacaaaaaag gctttaatat cctccataaa tgcttcacat gctgtaacaa gacagccgat 2981461 atgggcgtaa attcctgtaa tgatcagctg atcgcgtccc tctttgcgca tcatttcaag 2981521 cagattcgtt ctcttaaacg cgctgtatct ccattttgtc agcacaagat catcatcctc 2981581 tggtgccagc tcggttataa ttttctcctc ataaggaccg ctgtttaatc ccgggcccca 2981641 aaagtctgtc agcagcgcac ggtcatccgg attttggctt cccggctgtg cggtatagac 2981701 aacaggaatc ccaagctgaa cacattgatt cttcagcttt cgtatattcg ctgaaagctc 2981761 tgttaccgga gacgctcccg ctgtgaaagc atcaacaaaa tagttttgca tatcgtgtat 2981821 taacaagaca gcccgattcg gatcaggcac ccatgatact ttgttttgcg gcatatcaga 2981881 tgctgtcggc atttgatacg gctgaatggc aggtatagcc atatgaacac ttcctctcaa 2981941 attgttgttt tattttttaa atcctgcaag aagcttctcg gaaatggctt cacggagcgc 2982001 ttttttgctg acttttccta ctcctgtctg cgggaaggat tcgacaaatt caactcgatc 2982061 agggatttta tatgccgcca gtccgcgctc tctcaaaaat gctttaagct ctgcggcttt 2982121 tggggcttca tcccggggaa taatgaacac acaagatctt tcgccaagaa attgatcagg 2982181 catggagacc attgccgcat catggacagc cggatgcgcc agcagatgat tttctacctc 2982241 ttcagccgca accttttctc ctccacggtt aatttgatcc ttcgcccggc cttcaacgac 2982301 aatatagccg tctcgtgtca gcctgacgat atcacccgta cggtaaaaac cgtcctcagt 2982361 aaatgaagcg gcgttatgct cttctgcctt atagtaacct cgaattgtat acggcccccg 2982421 cgtcagcaga tggcctgttt caccaggttt tacgtcgcga tcatgatcat cccaaacacg 2982481 catttcatca tatggagaca tcggttttcc ttgggtgttg acaatgatct cctcaggatc 2982541 atccaatctc gtataattga cgagaccctc tgccattccg aacacctgct gcagcgtgca 2982601 gccgaaaaca gcttttaccc tgcgcgcggc ttcagcacta aacttggcac cgccgacctg 2982661 cagcacttga aggctggata aatcatcacg gcgtgaggat gccgcatcca tccataccat 2982721 cgcaagaggc ggaacaagag cggttatcgt gaccttttcc cgttcaatta aaggaaatgc 2982781 gtcatctgga cttggagaag gagataatac cactcttcct ccagcgtata atacgccgag 2982841 aacgccgggt gagctcagcg gataattgtg tgccatcggc agcgcggcca agtacaccgt 2982901 gctgtggtcg agccagcaga cctccacact ccgcttcagg ctgtatatgt agtcatcgtg 2982961 ggtcctcgga atcagtttcg atagcccggt gctcccgcca gaaagctgga ggaacgccac 2983021 atccgatgat ttgacttcag gcagttttac aggttctgca tgcaaatcct ccagcggtaa 2983081 aaattcctct gcctcacctg cgacaatgat gtttttcaaa gtcggcagct tgctttgaac 2983141 ctgtctggca agcgaacggt agtcaaaacc ggaataagcg tcgggaatga tatatgcagc 2983201 cgcttcagca aactcgcaaa aatatgtaat ttcactgctt cgatgagaag gcagtgcgaa 2983261 gactggaagc gcccccagac ggaaaagcgc gaaaatgact tcaaaaaact ctttgatatt 2983321 tggcaactgc accacaacac gatccatctg ttgaatgccg agcttttgaa atccggcagc 2983381 caggcgatca gcccttgtgt caagctctcg atagctccaa tgggtgtttc cgcatgtaat 2983441 ggcaatgcga tcaccatatt tggctgcccg gtcccttaac aaatctccaa acgtctcacc 2983501 ggcccagcag ccgttctttc gataggtctc agctaactca tcaggccaag gcgtaaatcc 2983561 tttcagcatg ttgtatccct ccagcaattc attctgttca tatgtgatcc acgcccattg 2983621 cccgcagcat tgtccgaaac tttgcggacg tctcctgaag ctcgtcctca ggctttgaac 2983681 cggccacaac accagctcca gcatacaggc ggagtgagcg ttcttctgct tctgcacaac 2983741 ggatggtcac gatccattct ccgtcaccgg catcgtcaca ccatccgacc atgccggtaa 2983801 agaaaccgcg gtcaaatggt tcaatgctga gaatcgcttc tcttgcaaga tcagtcggtg 2983861 ttccgcagac ggctggcgtc gggtggagcg ccgccgccaa ttcaagtgcg gttacagacg 2983921 ggtcggaaag ctctccctta atcacgctgg acaggtgcca catcgtttcc gttttgatca 2983981 gtgaaggctt ctccggaacc tccagcgtcc ggcagaaagg tctcagcgct gccgcaaccg 2984041 cgtcagcgac aaccgcgtgc tcatgaagat cctttgcgga agaaagcaat tcagctgccc 2984101 ggcgctggtc ttcaacagga tcattactgc gcggtcttga gccggctaat gggttggaaa 2984161 cgacctgtgt tcccatcctt gaaacgagaa gctccggact tgctccgagc aatgttctgc 2984221 ggggagacgt ttcctcctga ctggacacgt ctgcggcaaa cgtgtagcca tgcgagttat 2984281 gctgagccag atggcgaagc aattcatccg tctgaatcgg ttcaggcgat gtcaaatgca 2984341 gcgatctgga caggacgatt ttgctgagtg ttccatcggc aatgcgtgcc agcccttgtt 2984401 caacaccatt tttataatcc tcaggttcag gaacaggctt tatgtggtat gtatgcccag 2984461 cctgctgttc cttttcctca tgatcaaatt gaagcggtcc tgaccagcgc acttcttcag 2984521 gtacaacgag ccgcgctgct tttacttgat caaaaggaac ggccccgaca acaagcggcc 2984581 ggctttgccc tgattgtttt gcctgacgta acgcctctgc aattcggcca gaaagggttt 2984641 ccatttggtt ttgcccgtct gcctccggta caatttcaca tatgcctttc gctaacagta 2984701 cacgatgagg agacgctaag aaaaaggcgc ccggctgata ttcatgaagc aaatgctccg 2984761 cttttgtttc tgttataacg ttttgatcca acattctcat gaacctcctt taaattcagt 2984821 tacacgccta aggtcgcgcc gccatctacg cataaattat gcatcgtaat atgccctgcc 2984881 tggccagaaa ccaaaaagag caccgcatcc gcaatatccg aaggcttggc tagttttttg 2984941 agcgggatcc ctgttttaaa tgtctcaagt gatcctttta tgacttgctc cgctccattc 2985001 tcgtcggccc ataatgacca ctgcatgtct gtttccgttg atccgggaga tacaatgttg 2985061 cagcgaatat tgtattctgc aagctcaagg ccaaggcatt tcgtaaacat cacagccgca 2985121 gcctttgaag acgcatatgc cgccatagat gttcttggta caccggcagc attcgatccg 2985181 actgttacaa tcgaacccga tcttcggtcc atcatatatt tgctgactga acgcgaggcg 2985241 ttaaatacgc cagtcgaatt cactgagaac gtcgcctccc attcctcatc gctaagcgaa 2985301 tggatcagtc ccgggcgaag gacacccgct acattcacta aaatatcaat cggccccatt 2985361 tcacgttcga tgcgcgccgt gatctcgtca atcgccgcgc tgtctctcac atccgcagga 2985421 aaagcttctg catggcggcc ttctgctttg aggctgctca caaccttttc cagcttttca 2985481 ggattataat caactgccgc aatatgtgcg ccttgactgg caagcgtccg cgcaacagct 2985541 tcgcctattc cttgggcagc ccctgttata aaagcaattt ttccctctat accctttgca 2985601 ttcatatcat caattccttt cttcgctcta aatgccaaac agacatccag cgaaaaagac 2985661 tgctgcgcct tgaaaaacgc aatctattga taatgattat cattatcaat tataaaaata 2985721 atcatatcca aatgtcatgt gacagtcaaa tataatttca gtgacaaata tttttttaaa 2985781 ggcaaggctg agtatgtctc agcccattga tagatgcggt ccgtcagggt gaagcgcaaa 2985841 acgcagcgcc ctgctgacca aaacaggaag aactgaaata tgtccttctc ctgaaaactc 2985901 gcaaaattct gcccgtatac cttgttcaga taaaacggcc agccgctcat aaagctccct 2985961 tgcattatca ttcatccggc ttttatgatg ctgctctaat tctcctgcgg caagcaggat 2986021 attgataggc tgattgtttt tcttggtgag agagacgaaa tggtccgttt tcttgagaat 2986081 aaacggttta ttccaatgaa tggacggact tcccgcgata tacgtttgaa acgcatcggg 2986141 ctttgttagc agcacctgca gcacgaaaag ccctccgagc gaatggccaa agattgtttg 2986201 tcttttttta tcaatctggt aatctcgttc tatctccggt tttaaatcct cttcaataaa 2986261 tctgaaaaag ccctccgctc cgccatgctc cggccattct ctgccgtcgg gcctttccgg 2986321 cagcttcgat tgggctgttg gcattgtaaa atcccggtgg cgtgctgagg agaacggctc 2986381 cgctgtctca tagccaatgc cgacgatcac tgcagggatc accccggttt tttcgggtcg 2986441 gcgtccctgt attcgaacgg cttccgtcat cgttccgaag acagaattgg catccagcag 2986501 ataaatcaca ggataaccag cgggtggcgg cggcgtacta ggtttcgaga taaaaatgtg 2986561 ataggtacgg ttttcattgc gtgaagacat catacgcact tccgtaccag gaatcgtaaa 2986621 tgcgtttgat gtcccgccat ttgtccggtc tgttgtttgt tctttcatgc agtacgacat 2986681 tcctctcctt aaactaaacc gcaatgtatg ataatgattt tcactatcaa ctagacacct 2986741 caaataatag gttttcttcc aaagaaagtc aactttttcc cgaataaaaa aggcaccttg 2986801 atcaaataag gtacctgcag actatcaata tggaagtaaa aacctaataa agatgcgtat 2986861 tgtcctattt gaaatagaac cttaatccca tgtaaacctt tgattttgcc aagggtcgcc 2986921 tctcatgtga tagccattcc gctcccaaaa gccagggtga ttttctttcg taaattggat 2986981 gccgcgcagc cacttggcgc ttttccaaaa atacagatgc ggaaatacac cccgcagcgg 2987041 aaagccgtgt tcaggggtta aaggttcgcc attatgcgca taagccagaa gggaagtttc 2987101 cgctaagaaa tcatcaagcg gcagattggt cgtccagccc tcttcagcat gtaaaatgac 2987161 gtagcccgct tcttctttta cacccgcttt ttccgctata tcacaagccc gcacgccttg 2987221 ccacacatta tcaagccttg accatcccgt gacgcaatga atgtcgtttt tcgattcata 2987281 ccgtggaaag gctttgacat cttcaaagct tagcagcatc ggatggtcaa ccaaaccgta 2987341 tacttgaaga ttccatttcg tcatatcttc gtaatatggg acatctccgg tatgaagcac 2987401 aggaaatgaa gtggtgacgt tttgatttgg cggcactctt ccagattgat cggactgtct 2987461 tgtttttccg aaatacatat gggcctcctt tttgttaacc taatttaaaa tcatgttgac 2987521 aatctttttg ttctttatta ctctatgatt gtgtatgtca acctaagggg gaacaacgat 2987581 gaaacaacgt aaacttcgtg cgggagatat ggcgctgatt ggcatgttcg ccgcacttat 2987641 ggctgtcggg gccaacatta catcagtagc acccttttta caagtagccg gcattccgct 2987701 ttcgatgcag ccgtttttct gtctcttggc agctttgctt cttggcagca aacgggcagc 2987761 gattgccatg attgtatatg cacttgtggg attggccgga gcgcctgtgt ttgctcaatt 2987821 ttcagcaggc ttcgcaccgt ttgcagggaa aagcggcggg tttattatct catacattcc 2987881 ggcagcattt gcagcgggat ggtttttaga acgaaacatt cagccaagta aaattcgatt 2987941 tctcattgct tcacttatcg gaacggcgat catgtatctc atcggcacta cctatatgta 2988001 tcttgcactg aagctgtgga ttcatacgcc agtgagctac ggcacggctt ggggctttat 2988061 gatttggttt atggtaaaag atacagcgct ggctgtgata ctgtcgttta tcgcaccagc 2988121 aatctaccgc tctattcata aagcaaccgg ctttaacaga aatcacatat catctacgta 2988181 aaaaccgttc tattggacgg tttttttatc ataacgagaa aaggctcccc agtaaagggg 2988241 agcctttttc ctataaaaca agcgctgcaa tccagccaaa gatgacaagc ggaatattat 2988301 aaaatataaa tgtcggcaca caagtatccc aaatgtggtg atgctggccg tccgcactca 2988361 aacctgaagt cggcccaagc gtactgtcac tggcaggtga accggcatcg ccaagcgcag 2988421 cagcagcccc gataatcgca atcgttgcca tcgggctgaa tccaagctgc atgcatagag 2988481 gcacgaaaat ggttgtgata acaggaatgg tcgcaaaaga agatccgatc cccattgtaa 2988541 ttaataagcc gacaatgagc atcagcaatg cgcccaagga ctgactgtgt ccgataaaac 2988601 cagctgacgt tttgaccagt gactcgacat ctccggtttt cgtcaatacg tttgaaaatc 2988661 cggctgcaac aagcatgaca aagccgataa aggccattaa aaccattcca tcagtaatca 2988721 gtgagtccgc ttcatcacgc ttcatcacac cgctgacaaa cagaacaatc agaccagcga 2988781 gcgcccccat aatcattcct tctactccca aagtctgaga taagtaaagc tggacgccga 2988841 gtgacacaac aatggctaga accgcgatac caatactttt tctcgtatat ggcgatgctt 2988901 ctgcacctga aatgtctttt gtttcatatt gtttcggttt acggtatacg atcactgata 2988961 aaataaggcc gacaaccata cctgcaactg gaataatcag tgcgtacgga atatcagcaa 2989021 gcggaacgtt taacccggca tccgccatat tgtccttcag catgccttgg aagatttggc 2989081 cgaaaccgac cggaagcaaa atataaggag ccgttaagcc aaatgtaatt acacacgcga 2989141 tcagacggcg gtccatttca agttcattaa agattttcaa aagcggcgga atcagcaccg 2989201 ggataaacgc gatgtgaacc ggaacgacgt tttgcgaaaa acaagataca attaaaataa 2989261 tcagcacaat cagcacctta gacagtgctt tttttcgaga atcttcttta tttccgatta 2989321 atttaacgga ggcttccacc attgcgtccg gaagacccgt tttcgtcaaa gcggcggcaa 2989381 acgcgccaag catggcatag ctaactgcaa cggtggcatt tccgccgaga ccgtctgtga 2989441 aagctttaac cgtttcgcca agaccgagcc cgcctgttaa cccgccggcc aaggcgccta 2989501 taattaatgc gataacaata ttgacacgca gcaggcttaa tacaagcata agcaggactg 2989561 cgatgacgac tgcattcatg atgatacccc tccaaaaatc ctttagtttg ctaatgtagt 2989621 agataaataa agtacgaacg tatcgtatca taaccgatcc actttagtca actaaagatt 2989681 tcggaagaaa aaatccctgc cgcatcatac agcagggatt tttcattact cgtttttatc 2989741 ttcttccaat gtaaatcgct ccgcaagtgt agccagtgtt cttgccataa cgccagtagc 2989801 cccggccggt ccgaagcagg ttgctttatt ggcagtcgct gtgcctgcaa tatcaaggtg 2989861 aacccaaggt gttgactcag cgaattcacc aagaaacgtt cctgccataa tcgcatgtcc 2989921 ctcgcgtccc ggtgaattgc tgagatccgc catttggctg cttttcacgc gttttttatc 2989981 cttctctgtt atcggcagct gccagatcgc ctcgccgcac tcttgtgcag catcagctac 2990041 ctgctggtaa aagctttgat catttgtcat tgcaccggtt gtttctgttc ctaatgccac 2990101 aacgacgccg ccggtaagcg tagctacatc gacaagaact gatgcgccat gctgtttcgc 2990161 gtatgtaatg ccatctgcaa gcactagcct tccttcagca tccgtattaa ggatttctat 2990221 tgtttttccg cttaaagata cgatcacgtc atccggcttc atggccccgc cggagatcat 2990281 attatcggtt gatggaataa cgcacagcac gttttgttca ggacgaagct ctccgatcgt 2990341 ttccatagcc ccgagaaccg cagctgctcc tcccatatct gatttcatgc caacaattcc 2990401 agatttcgtt ttaatggagt agccgcctgt gtcaaaggta attcctttcc cgactagtcc 2990461 gacgacgtct tcccattcct ttttgccctg atatttcaac acaatcattt tcggcggttc 2990521 ggtggagcct tggtttaccg caagtattcc gcccataccg agctcttcca tctctgattt 2990581 ctccaatatc tcacactcaa aatcatattt cgccgcaagc tcttcagcat acgaagcgag 2990641 gtcagtcgct gtcagcatgt ttcccggcat attcacaagc gttctagccg aatttgtccc 2990701 ttgtccgtat gcctggccga cgcgaagccc tgcctgcact tcctgtgtat cttcatctgt 2990761 tacaacatac acggcttcaa tttgtttgtc aggctcattt gatttatgct tataatcctg 2990821 cacctcatag gaagcaagca ggcagctctc agctaaagca tgagcggcat cggctggagg 2990881 cacgtcttcc gaaataaacg tatcaagcag aacagcagtt tcttgttttc gatctttatg 2990941 aatggcttga aaaacatgag caaaacgttc cttcgcctgt tcaaacgaat aatttgcttc 2991001 tctccccagg ccaacgaaat aaatccgttt catacccgca gaagatggag ggaatacttt 2991061 tgatacttga ttcggtttcg cagagacatc accctctttt aaaagctgtg tcagatggcc 2991121 ttcgagcatt tcatcaattt ccaacgcttt tcctgtcagc tggctttttt gaaaaagccc 2991181 gacaacaagg gtttctgtat gctctgattg ttgaaccgca taaaacatga ggcttacact 2991241 cctaacgtaa tgggtatttg taatgaacaa tggtataata ggaaaaacat tctttccact 2991301 atacttattt taacaaacaa cagtctaaga cttgcttttt tcttttgaaa cacgaaggat 2991361 ttttcaaata gaaaggatgt cgccgatgga acttttaacg aattttcctt tattatcaag 2991421 cctggccgca attatttttg ctcaggtcat caaagtgccc atacagttta tcgtgtccag 2991481 aaaactggac tggtcgctgg tcacaagcac aggcggcatg cctagctctc actccgcagc 2991541 ggtcactgcg ctttctacag gcgtagcctt ggagcatgga ttagactcct cactctttgc 2991601 ggtttccgcc attttcgccg tcataaccat gtttgacgca actggcgtca gacgtcacgc 2991661 cggtgagcag gcaacagtca ttaataagct tgttattgat tttaaccgtt tcgtaaatga 2991721 agcgaaggac ttccctaagg ctgcagagaa agaaaagcaa aaaaagctga aagagcttct 2991781 cggacatcag ccgatcgaag tctttttcgg aggattaaca ggtattttac tgacattggt 2991841 actcgcttac tttttcatgt aaaaaaaacg ctcctgcttt cgctggagcg ttttattctt 2991901 tcaccgtttt atattgattt ctgaacactt gcaaagattt tgtttcattg agcttctcaa 2991961 gctcatcctc ggtaatcttt cccgttccct ttttaatcac atatacatca agggtttttt 2992021 tgccccattc attgtataca tctttgactg tctcaaagta cagatcaagg cggtttccct 2992081 taatagctga tcctgtgtcg gccacaactc cgagaccgta gttcggaatg aataaaattg 2992141 ttccgatcgg gaaaacggac gggtcagcag caaccgtgga atataaatcc cgtttcactt 2992201 tcacacctga atatgtaagc ccgtataatg gatcaccggg atttttgccc gtcgactcag 2992261 ctcctgctgt gtagcctgtt gctgttactc tttggactgg atattcatcc caatcaaatg 2992321 cctcttctaa cggttttgtt ttatcctcag ccgcggacgt ggtttgtgtt tgtttctgct 2992381 gcaatgcttt taatctcagt cctgcatgct tcaagtgctt ttcctgatgt tcctgcaccc 2992441 attttgacaa gtccttcgct tcaattcctg acactgataa aaatgtcgtg ccaaatgcaa 2992501 gcagaaataa acaggtcatc agcaaacgtc tgatcatatt caacatcatt cacctctcct 2992561 ccgaatcatt gttcccaagt ggagagagca ttattcaaaa tggtgaatga gctgaacgca 2992621 taaaaaaagc tttctttaga agaaagcggc atttaaaaca tttgatatcc tctttttcta 2992681 agcatgttga tcgctatacc ggacacgatg gcgccggcca aaccgctgac taaaatcagc 2992741 acatcagcag ccgctaatga taagacacga tgaaacaggc tggcaaagga ttctcccggc 2992801 gactggacat agctgatcag cttttctttg ctgataatga aaaggcatac aattggataa 2992861 atcacagcca taatccaaga cattctcagc agcatgttta ataagaaacc gattccaaaa 2992921 aacaagacaa aaaacaaaac aattgagatg attacgactg gcagactaat caacctattc 2992981 cacccccctg cgttgttttt agtgtaacgc gggggctgaa ataaagtcaa cggctggaaa 2993041 aagaatgact gtcttttcct gtcccctggc aagacggaca agtctctgaa ccgccgagaa 2993101 tcaattgaaa atatcctttc cctgaacaaa atgggcatgc atgtgaagcg gttgtcgttg 2993161 cagttttcat ctaatcatca ccctttttct taattttctg ataatatacc atatcaagct 2993221 gtcaacaata aagtcagatc atgtgacaaa tcttttgatg taagcggaaa catacttgtt 2993281 ttcctctcgt tctcttttta ttttggcgtt ttttaataaa gaaaacccgc ttccgcgggt 2993341 ttttagaaaa acttgaactt gccttttttc aatgtcagtc cgagtccgcc aatcataaac 2993401 agtgagcggt tatcaatgac ttttttcata aacgaagcgg gcgtgccttt cagctttctg 2993461 ccataaacaa ccccaaccgc gttatgctcg ccaagagaag ccactgttcc cttaatgtcc 2993521 ggcttgaatt cctcaagctc tccgccttta ataagcctgc caaggttttt agcgaccgtt 2993581 atgccctgct gcattgcaat ttgcgcagtc ggcggatacg ggcgctctgt atcttcattc 2993641 ataaacagcg agctgtcgcc gagaataaag acattgtcat gtcccggggc gcggagatca 2993701 gggttgactt tgactcggcc gcgcatattc tcaaaaccgg cttcctccac aatcggatgg 2993761 ccgcggacac ctgccgccca tacaacggtt tgcgatttga tctgctctgg ttcttcatct 2993821 tttttgccga ctctgactcc ttctggtgta cattcttgta cagccgttcc gatcttgaac 2993881 tcaactccgt tttcctcaag ataatgtacg gcgtaatcaa caagttccgg atcaaagccc 2993941 ggcaaaacgg tcggcgctgc ttccacacaa atgatgcgga caaggcttct gtcaacgtca 2994001 tattccttac agagctccgg cacgcgagca gccagttcgc caagaaattc aattcccgta 2994061 aatccggcac cgccaacaac gatcgttaac ctgtccggcc gtttttccgc ttccgtattg 2994121 taagtcgcaa actgcagctc aatatgttcc cgcagcaggc gcgacgtgtt gatgttggca 2994181 atcggaaacg catattcttt taagccttta atgccgaacg tttcaggcac ggcgccgagc 2994241 ccgatgacta aataatcgta ctgcaattct ccattcgcaa gcacaacttt tttctcatca 2994301 attttgattg cctttacggt atcctgtaca aaattcaccc gtgactggtt gattacatct 2994361 tttatctgat aacggcagcg gtcatgatgg agcgtacccg cgctcgcttc atgcatccat 2994421 gtcgtttcat aatgataatt gtgtttattt acaagcgtaa tgtcagcatc attcggcccg 2994481 acatacttcg tcagccttgt caccgtcatc aatccgccat atcctgcacc taaaatcacg 2994541 attttgggct tattcaatgc catcacatcc accttctctt tttttgcttt tgttagaccc 2994601 ataataaaat catcatttgt gttagcttca gcttattggc gggattttat gaaatatatt 2994661 gaaaagtttt ttgtgaagtc cttacccgta gcactattat catgtttatc cggctggccc 2994721 aagaaacatt cagaaaaaga tcatttcatt tggttattat cgtagcggcc tgcggaaata 2994781 ttttcaagaa cggatgggca cgttagatcc ttacgatttt ttctgctgac tcgtcaattt 2994841 gaacggcaat atggtataat taataacaat tttcatttag gaggcaattt tcgtatgcga 2994901 gaggatacaa aggtttatga tattacaatt ataggcgggg gaccggtcgg cttattcacc 2994961 gctttttacg gcgggatgag acaggcaagc gtcaaaatta tcgaaagcct gcctcagctc 2995021 ggcggacagc ttagcgccct ataccctgag aagtatatat atgatgtagc gggattcccg 2995081 aaaatccgcg cgcaagagct tatcaataac ctaaaagagc aaatggcgaa attcgaccaa 2995141 accatttgtc tggagcaagc ggttgaatct gttgagaaac aagcggacgg cgtgtttaag 2995201 cttgtaacaa atgaagaaac ccactactct aaaacggtca tcataactgc aggaaacggc 2995261 gcattcaaac cgagaaagct ggaacttgaa aatgccgagc agtatgaagg caaaaacctc 2995321 cattacttcg ttgatgatct gcaaaaattc gccggcagac gcgttgcgat ccttggcggt 2995381 ggagattccg cggttgactg ggcgcttatg cttgagccaa tcgcaaaaga agtatcgatc 2995441 attcaccgcc gcgacaagtt ccgagcgcac gagcacagtg tggaaaacct tcatgcgtcg 2995501 aaggttaatg tcctgacacc attcgtccct gcggagctga tcggcgaaga caaaatcgaa 2995561 cagctagtgc ttgaagaagt gaaaggcgac cgcaaagaga ttttagaaat tgatgactta 2995621 atcgtcaact acggtttcgt ttcatctctt ggaccgatca aaaactgggg cctggacatc 2995681 gagaaaaatt ccattgtcgt gaaatcaaca atggaaacaa atatcgaagg cttctttgca 2995741 gcaggtgaca tttgtacata cgaaggaaaa gtcaacctga ttgccagcgg cttcggcgag 2995801 gcaccgacag cagtgaacaa cgccaaggct tacatggacc cgaaagcccg cgtacagcct 2995861 cttcactcaa caagtctttt tgaaaataaa taataaaaaa aggagcttgt gtctgcgaca 2995921 cagctccttt tttatttgaa gatatttata taattcaatg cagttcctac aaccagcgca 2995981 atcacaaggg ctgcgactac ccagatcatt gccataataa tgcggtcctg aatcttttgg 2996041 gacttcggtg ttttttcttc gttttgggcc atcttattcg ctcctttccc atgtccatgc 2996101 cataaagaaa gcctggtgct gaacgaccaa gctttgctga acgtatatca ttcgcgtttt 2996161 gatccgctct ctaagaccat tcgttaaaac tatgatacct aaactcaccc tgcatgacaa 2996221 gcttcggcac ttgcaccaca cctgccagca aatcataatg tttgacatcc taaataaaac 2996281 agagtacatt atataaggcg aacatttcat atattatact tttaaatatt cgtttttagg 2996341 agtgaaaacc atggaaaacg tatttgatta cgaagatatt cagctaattc ctgcaaaatg 2996401 cattgtgaat agccgttcag aatgtgatac atccgtacgt ttaggcggac atacatttaa 2996461 attgcccgtc gtccctgcca atatgcagac gattatagat gaaaaactag cgatttcatt 2996521 agccgaaaat ggctactttt atgtgatgca ccgatttgag cctgagacac gaattgattt 2996581 tattaaagat atgaacgcac gcgggttatt ctcttctatc agcgtgggcg tcaaagatga 2996641 ggagtatgaa tttgtccgcc agctggcaga agaaaatctg actcctgaat acgtgacaat 2996701 tgacattgct cacgggcact caaatgctgt cattgaaatg atccagcacc ttaaaaaaca 2996761 tttgccggac agctttgtta ttgctggcaa tgtcggaacg ccggaagcgg tcagagagct 2996821 tgaaaatgcg ggagcggatg ccactaaagt cggcatcgga ccgggaaaag tatgtattac 2996881 gaaaatcaaa acaggcttcg gcacaggcgg ctggcaatta gcagcgctgc gctggtgtgc 2996941 caaggctgcc agcaaaccga ttatcgcgga tggcggcatc cgcacccatg gcgacatcgc 2997001 aaaatcaatc cgattcggcg caacgatggt catgatcggt tcactatttg ccggacacga 2997061 agaatcgcca ggccaaacga tcgaaaaaga cggaaagctt tacaaggagt acttcggctc 2997121 agcctctgaa ttccaaaaag gcgaaaagaa aaatgtcgaa ggcaaaaaaa tgcacgtggc 2997181 gcataaaggc tcaatcaagg atacactgat tgaaatggag caggatcttc aatcttctat 2997241 ttcttatgca ggcggaacaa agcttaacgc catccgcaat gtggattatg tgattgtgaa 2997301 gaattccatt tttaatgggg ataaatatta atcataaaaa aacgccaagt cagcggttct 2997361 ccgcttgagt tggcgttttc tgctacttct tcagcaaagt aagcttatat ttgctttttg 2997421 agtttatctt ccatcagttc tgccatttgt tttgcatttg gattttcttc attttgcaac 2997481 tgttcaatga cgttcatata atccgtttca tttcggttct ggcttaattt atatgccgct 2997541 tgaatgtctt ccaccttaat cttaaatcca acaatacctt tcaattcact ttctaagagt 2997601 tttggagaaa gcttatccca taacacagga ttgtcacgat gtttttcgta tttctccaac 2997661 atgattgtta attcttctgc taattcatct ttctctaaca tacttgcttt tccatacatg 2997721 tggacagcct gataattcca cgtcggaaca ttttcgcgcg aataccagga agaagaaata 2997781 taagcgtgcg gtccctgaaa catcacaagc acatcttcac aggcttcaaa cgttctccac 2997841 tgaggatttc cataagcgaa atgccccgta atatagtaat gatcgtcttt tttattgaat 2997901 cctaacggca aatgtgtggc aattggtttt ccttgttctg ttgtgacaac cgtaccaaag 2997961 gagttttctt gtacaaaatt ccaaatttct tcagcatttg tgactttaaa atattttgga 2998021 atatacatca tcatccaccc ttcgaaaaat attatatgag tgttttagcc atgattaaat 2998081 ccgtttgttc ttcatcaccc atataaaatg agtgggcgcc ggtctgaaca aaccccattt 2998141 tcttataaaa ggcaatggca ttttcatttt tttcccacac acctagccaa atgttctttt 2998201 tattacgttc cagcgcaatt tctatcgctt tattcagcag atgtttgcca agcccatgtt 2998261 tttgaaagct gttctttata taaattctct cgatttcaag tgattcagca cccatttctt 2998321 cagactgagc atcatcgata ttgaccttta catatccagc gatttcatga tcaaagtaaa 2998381 taaaaaagaa ttgcgaagac atattagata actctttttc cagctgctca gtgttaaatg 2998441 cgctttctaa ataggctttc atattttcag gtgagttctg ttctttaaaa gtgtcattga 2998501 atgtttcaat actcaattgt tgaagtgttt gtaaatcttc ccggctgcat tttttcattt 2998561 ttacactcat tgttcggatt cagccccttt atttaaaatt caattgtctt gtgtcccttt 2998621 tatatattta aacacggaac acatactgac cttgttacca ttccaaaaat cttcttcatc 2998681 accaactccc tatcgtgatt ttgttgtaaa tgcaataaaa tatactccgc attaaatata 2998741 tcgtaacttt gctgtattta caacaaaaat caaacaacaa agcagcgttt ctcttgccga 2998801 agttcccgga actctctgca tcatttcccc ataataaaaa cgcctccctt aacgatgatt 2998861 tatcgctaag aaaagcgtca gtaatagttg ctatccgttt ttagtgctta gcactcttca 2998921 ggcttgcctg cattcgttgc tgttctgaac gaagaaccgc agccgcatga agcgatggcg 2998981 tttggattgt cgatggtgaa gccgccgccg agcatggatt gtttataatc aatcacggtg 2999041 ccgttcatga tgtcaaggct ttctttgtca actagaacag tgatgccgtg ctgatcaaac 2999101 acactgtctg attcactctt ttcatgctca aagcccatgc cgtaagaaag tccgctgcag 2999161 ccgccgcctt tgacgcctac acgcagaaac gcgttttctt cttcatgctc tttcatcata 2999221 tcttttatat gcaaagctgc tgcttctgta attgttaccg ggttgctcat cattatgaac 2999281 ctccttttaa aaaccggttg ctgtctttta ttataaacat gatcgttcca attctcaaac 2999341 aaggtgtttt acaagaaata gacaccctca caaacggttt cagccggccc tgtcatcatt 2999401 acatggccgt tatctttcca gtttatcacc aaatccccgc ctgctaaatg caccgtgatg 2999461 tcttgatttc gctttgatac gccgtttaat acagatgcga ctgccgctgc acatgctcct 2999521 gtcccgcatg cctgagtaat ccctgatccc cgttcccaga cgcggaaatg caattcttgt 2999581 tcattcacgg tttcaacgaa ttccacattg atgccttccg gaaatctcgg atctttctca 2999641 atcaccggcc ccagtgtcgt taagggtgcc tgttcaatgt ctgcgatcgg aaaaacgata 2999701 tgcggatttc ccattgaaac ggcagtgcct gttagttcta cttcaccaaa tgccatcgtt 2999761 tcattgattg tgtgctcttc cccgccgtca agcataggaa gctcggattt tgtcaagcgc 2999821 ggttcgccca tatcgacagt gaccacattc acttttccgt tttcgacttg aacctccgct 2999881 ttcacaagcc cggagagagt ttcaatcaga aaagatgttt cctcaaccag cttatgctca 2999941 tatgcgtatt ttgcgacgca gcgcaggccg ttgccgcagt ttttcccttc agacccgtca 3000001 ttattaaaaa tccgcatttt aacaggcgct tggtctgatg ggcatatcag gatcattccg 3000061 tcggatccga tccctgtata aacagaagaa acctgaattg caatctctga cagtttttct 3000121 tctggaagct gttcttcaaa ttgattcaca taaatataac tgtttcccag gccgtgcatt 3000181 ttggtaaatc gaaatgagtt cataggtgcc tccaactttt tttctttttc ttagtataaa 3000241 agctattata agcggacaca atacaattat cccccgtttt tcatacataa aagctccttg 3000301 cactgacgca aggagctttt atcgtttata taaacatgcc ggcaatggct gcgctgagca 3000361 gattggctaa tgttcctgca agaacagcct tcaggccgag acgtgcgata tctgaacggc 3000421 ggctgggcgc taaaccgcca agcgtaccaa gcataatcgc aattgatgaa aaattggcga 3000481 atccgcataa cgcgaaactg ataatggtag cagttttctt agaaaactcg ccgatgtgcg 3000541 aaccgaagtt agaataagcg acaaactcat tcagcaccaa tttctggccg atatagcttc 3000601 ccgcctgcaa tgcttcatgc caaggcacgc caatcaaaaa ggcgatagga gaaaacacat 3000661 agccgagaat ggattctaat gttacgcctt ttaaaccgaa caagccgaaa gccccgccga 3000721 gaataccgtt tactacagcg attaacgcaa caaacgcaag cagcatcgcc ccaacattta 3000781 acgcaatttg cagtcctgtt gacgctccct ttgcagctgc gtcaatgaca ttggctgcgc 3000841 cttcgccttc atccattttg aaatcgcttt ttacggtttg cgttttttcc gtttcgggta 3000901 taatcaattt accaaagact agtccagctg gagcagccat aaagctggcc gccagcaagt 3000961 actcaatcgg aataccgaga agcgcgtacc caaacaaggt agatcccgca actgccgata 3001021 gaccgctcgt cataatcgta aacaactcag agcgcgtcag cccggcaatc aggggtttga 3001081 tcactaacgg agattctgat tgtcctacaa aaatattggc agcagccgcc agagattccg 3001141 ttttgcttgt tccaaggagc ttcgacaatc cgccgccaat gacacggaaa acgagctgca 3001201 tgattttcaa atgatataaa actgcaatca gtgctgagaa gaaaatgata acgggcagta 3001261 cacttaatgc aaatgccgga ctgtctccga cctttagaag cggtccaaaa ataaaactga 3001321 tgccttcatt cgcatagtca atcagaagct gtacacggct tgaaaaccat aaaaaaacag 3001381 cgcgtcccgc ttcccatttc aacacgatgt atccaaacgc cacctgtgtg cataaaccaa 3001441 cgatgacggt tcttatctta atattgcttt tcttttctga aaataaaaac gcgatagcaa 3001501 tgatcgcaac tgcgcccagc agcccccaca gaacattcat gaatactcgt acacctctta 3001561 aattttattt aaaaaaatat cttttatacg ataacaataa tattttttga tgtctacaca 3001621 tttttttagt tcttttgtac ggcaaaataa aaaagggcct gtccaggccc ttttctttaa 3001681 aacattggat tttcttcaat aaaggtatat atattctcaa caagctcagc aggcgtttca 3001741 cccatgacga cttctccgtt taccagagcg aaaagcgatt ccatacatgt cccgcagtag 3001801 cttaagcagc catattcaag gacatcaagg ttgggatcct tctccaaaat cgcccgggct 3001861 tcctgagagc cgtgagccag attgctgaca caaaattcaa tcattggatt catgcggttt 3001921 cacctcacat atgtccatta tcgcgaattt ttcactattc gtcaaagaca acggatgatt 3001981 caaaatttat tatcgtaaca tattatttct caaataacgt tttactaatt tgtgttttca 3002041 ggctaaattg taggttattt tgaaactatt attgtgattt tagatcaaat tcgatataat 3002101 tctagatgtt attttacata gttcgtattt tcttcaatgt atctatcata ctcttcggat 3002161 taaaggggaa ttcaaatgaa aaaattggtc ttgatcggcg gaggttacgg gaacatgcgc 3002221 gttcttcatc gcttattgcc aaaccagctg cctgatgatg tttcaatcac gttaattgac 3002281 agaaatcctt atcactgctt gaaaacagaa tattatgccc ttgccgcagg cacaatttct 3002341 gaccatcata tcagagtgtc attcccagag caccctcgcc tggatgtcca atacggtgat 3002401 atcacatcaa ttgatattgt acaaaaacaa gtgctgttcc aagatcgtga accgatttct 3002461 tacgatgacg ccataatcgg gctcggctgt gaggataaat atcacaacgt gccgggagcg 3002521 cctgaattca cctacagtat tcaaaccatc gatcagtccc gcgaaaccta ccaaaagctg 3002581 aataatctga gcgctaatgc caccgtcgcc attgtcggag cgggcttaag cggcgttgag 3002641 cttgcaagtg aattgagaga aagccgtgat gacctgaaca ttattttgtt cgaccgcggt 3002701 aatctcattt tatcaagctt tcccgagcgt ttaagcaaat atgtgcaaaa atggttcgaa 3002761 gagcacggtg tccgcattat taacagggca aatatcacaa aagtagaaga aggcgttgtg 3002821 tataaccacg atgatccgat ttctgcagac gccatcgtgt ggacagccgg catccagcca 3002881 aacaaagtcg tcagagactt agatgtggag aaggacgcac aagggcgtat tgtattaacg 3002941 cctcatcata atcttccagg tgatgaacat ctgtacgttg tcggcgattg cgccagtctt 3003001 cctcatgcac cgagcgccca gctggcagag gctcaagcag agcagattgt ccaaatcttg 3003061 caaaaacgct ggaatggaga agccctgcct gaatcaatgc cgcagtttaa gctgaaaggc 3003121 gtcctcggtt cactcggaaa aaaagccggc ttcgggcttg ttgctgaccg tccgctgatc 3003181 ggccgtgttc cgcgtatgct gaaatccggc ttgctgtgga tgtataaaca ccataacggt 3003241 taatgataga gaagaaccgc tgatcaagtc agcggttttc tgtataccca tgcttctcca 3003301 tttcctcata aacgtctttt aattttggat tgccttcacc gacaattttg tcttctacaa 3003361 gcacaagcgg ataaaaatac tcgtcatttc tgattttttc cgcaagctct ttcgcatgtt 3003421 cattgtcagg cggctcatga atatcgatgt actgcatctc aaaaggctga tttggatatt 3003481 ttcttttcag cgcagcctca agccactcgt atgtatcctt ggctgtcggc atatttacac 3003541 agctcgcaca aacgttttct gccccgtaca cgcttagcat gactggtttc atcacttgta 3003601 gacgccccct tctcctatgt aagtcctttc ttttaagtat acagagccta agggcgtttt 3003661 tatagaaaaa aaccgttttt gtgttgaagt ctgaatgtgc tataataggg aaagcaactt 3003721 tgcaaaccaa acaatagatt tttattgtta cactgaatat aatggtttta tgacgacgaa 3003781 aggagcgaat gtcatgactg aagttgaaat gaaagaacag gtgcaggaag tactggacaa 3003841 acttcgtccg tttttacttc gtgacggcgg tgactgtgag cttgtagacg tagatgaagg 3003901 tatcgttaag cttcgtcttc taggcgcatg cggcagctgc ccaagttcaa caattacgtt 3003961 gaaagccgga attgagcgcg ctcttcttga agaagtgccg ggtgtcgttg aagtagaaca 3004021 agtcttttaa taaagcagcc aggctgatat ttgatcagcc tggctttttt attagagatg 3004081 ttgatcaaac catgagctga tataattcag gcgcttgatc cgctgtcttg ggtgtccggt 3004141 gcgtgataaa ttgtgcgatg cattcggaaa acggacaagc ttggtttcct tgcccatttt 3004201 tttcagagcg ataaacagct gctccgcctg ctcgatcggg catcggtcat cccgctcgcc 3004261 atgcagtatc aaaagcggtg tctccacgtt tgctgcgtat tttaaaggag accggtccca 3004321 gagcttttct gtgtcctcaa acatgtcatg ctcaagctgc cagtctgtaa agaaatagcc 3004381 gatatcactg acgccgtgaa agctgatcca atttgatatc gagcgctggg taacggcagc 3004441 tttaaagcgg ttcgtctgcc cgacgatcca gttggtcata aaacctccgt agcttccgcc 3004501 cgtgacaccg agccgcttag gatcaatatg cggatctcgt ttgatagcct catccacagc 3004561 ctgcatcaca tcgtcataat cctttccccc ataatctcct ctgaccgcat tcacaaattc 3004621 ctgcccgtag ccgtggcttc ctctcggatt gatataaacg accgcgtatc ctttcgccgc 3004681 cagcacctga aactcatgaa aatatgtatg tccgtacatc atatgcggac cgccgtgtat 3004741 gttaagaata agtggatatg ttgtctcacc ttccatttgt gcaggcctca tcagccagcc 3004801 gttcaccatc acgccgtctt ctgtagcata ttgaatctct tcaggtattg atatcgtatg 3004861 ctccctgaca aacttgtcat tcgcgccagt cagctgtttc tcttcctgtc caagcgggat 3004921 actgtaaagc tcactcggtc tgtccggctt tgtcacactg gcaataaagt gctgttcatc 3004981 aggtgaaaga gaaaagctat tgatgtactc tttttccaga cgaatcggat acacaaggcc 3005041 ttcaatcgaa atataataga tgcccgtact gccttgatct gtgccgatga cataaaaccc 3005101 ttggctgtcc tttgtccaaa tcgggcgctg ttcagcacca ccgatcaatg aatctccaat 3005161 cagcgcatcc gctaaatgaa cgtccagcat ctcagtaaga catgtgaggc ggccttgttc 3005221 gatatcatag agccacgcct ttgagagcgt agcattctta tattcctttt catttccaag 3005281 caaagcaaga taccttccgt ctggtgaaaa tgagcttgat ccgaatgagc cgcgatgagg 3005341 tgtaacctgc ttaagatctc cagactccag tgacattatg taaacatcat gcggcttgct 3005401 ggcatcatct gtttcagtta aattagctga gaaaacaagc catttgccgt caggagaaaa 3005461 agcaggatca ccatgatcag ctttgtgact tgtcagctct ttcatctcac ccgactttac 3005521 gctgacaagc acaagctggg catacgcacc tctcgtcagc cctttgccgt cccgtttgta 3005581 ggagaggcct tgcacttcaa caggttcata gctgtcctgc tctgtttttt ctcggtcatc 3005641 aatgctttcc ccctctccca aactgacagt gaccagaatc gattcaccgt ccggggacca 3005701 tagcggcttt gacacgccat atgggatatc agtcagtttt cttgcttctc cgccttcagt 3005761 gctcatgata taaagctgtg ccgcatcgcc ttctcgatca gaaataaagg caagcgtgcg 3005821 cccgtccgga gaccatcttg ggtcggtgct tcgcttttct ccatgtgtcc aaggaacaga 3005881 tcctcccgtt ttcgtttcat agatccatat atttgatgta tacgaatctt tctcttgatt 3005941 tacttgtgat tttacatatg cggcacgggt accgtctggg gcgtattgag gatcggtcac 3006001 agagacaatc gctgtgatgt cgtctgcggt tatcagcttt ttcatattca tctcctcctt 3006061 tttacatgta tttcgttttt ctaaataaaa actcctttat ctccagcaaa aaaaagcgcc 3006121 ctccgctgac gctgaggaac gcttggcatg atctatacac tttttacttg atataaagga 3006181 tttcgctcta ttatacttcc ctctttcgga acggtcaaag cgtctacttc acaatgaggg 3006241 aaatgaagcg cgagctgttc ttttagctct tctccctttc ctttttcggt catgacgaga 3006301 atcgttgggc ctgctccgct gagagccgtt ccatatgcgc ccttcatctc ggcgacgtgc 3006361 tctacttttg acagctcagg cacaagcatc gcccggtacg gctgatggaa catatccttc 3006421 ttcatgattt tcccgacaag cggccaatcc ttggacatga tcgcagcaat gaggatattg 3006481 ctgacagcac ttgcttttac ggcatcggca tatggaaact ccttcggaag cacgtctctc 3006541 gcgtctcttg tcagcacttc ataaaaagga atgacaacga ctacgtcaat gtcagcattc 3006601 gggacgcgga tcatttgggt ctcgtcatcc tcatgcaggc cgatcacaag tccgccgacg 3006661 agagaagcgc cagcattgtc cgggtgtcct tcttctagac tcgctaaatg cagcttgtcc 3006721 gcttcagaca gctttaagcc gcataattca tcagccagtt caatggccgc tacaatcgct 3006781 gcggcgctgc tgccaaggcc gcgtgcaagc gggatgtcgc tccacacctt cacatggaca 3006841 ggaggcattt cttttccgta caaatctgcg gtccgtttag ccacttggta gatcaggtta 3006901 tctgtacccg ccggaattcc ggcgactgtt tctgtttcag cctcaaaaga ccatttgtcg 3006961 ctttcaaaga cggtcagctt caaatatctg ctgagcgcca ttccgactga atcaaagccg 3007021 gggcctaggt tagctgtgct tccgggaaca gtgacagaga acagcatgtc ggcttcgttc 3007081 atacacgggc cgctcctttt acatattcaa ggatgctgtc ttcatcagtc ggcaatgtga 3007141 caggcttgat ttctgaaatg tcgaccgctg tgttcggatc tttcagtccg tttcctgtta 3007201 acacagctac gaccttgctg cctttcggaa tttctccgga tttcacctgt ttcagcactc 3007261 ctgcgataga cgcgcaagaa cctggttctg caaacacgcc ttctacacgg gcgatcagct 3007321 gatatgcgtg aaggatttca tcatcagtga cttcgtcaat tttcccattg gattcctcgg 3007381 ctgcctttac agctttgtcc cagcttgccg ggtttccgat acgaatggct gtcgctattg 3007441 tttccggatt ttcaatcact tcattgcgca cgattgccgc cgcaccctca gcttcaaagc 3007501 cgcgcatttt cggaaggcct gtgccgtttt tctcatgata ttccttgaag cccttccagt 3007561 acgcagtgat gtttccagca tttccgaccg ggatcgctaa aacatcaggc gcttccccca 3007621 gctgttcgca cacttcgaag gcagcagttt tttggccttc aatgcggtaa gggttgactg 3007681 agttgacaag ggcaatcggt gatttctcac agatggaacg gacaatttta agcgcatcgt 3007741 caaagtttcc gtcaattgcg ataatctcgg ctccgtacat gacagcttga gcgagttttc 3007801 caaatgcaat ttttccgttc gggatgatga caatgcattt catgttagca cgggctgcat 3007861 atgctgccgc agcagcggaa gtgttacctg ttgacgcgca cataatcgtg tcattgcctt 3007921 cttcttttgc ctttgccaca gccataacca ttccgcgatc tttaaatgat cccgtaggat 3007981 tgacgccttc cgttttgaca tgaagctcaa ttccgagctg ctcagacagc ttcggcaggt 3008041 gaataagagg tgtgtttcct tcatgtaaag ttagcgccgg tgtttgatct gttacaggta 3008101 aaaattcttt atattgatgg ataagtcctt tccacattag ctccaaccgt tcccttctac 3008161 acgatatgtg cttttgactt cttgaacgac ttccaaatca tttaggtttt gcaggatatc 3008221 actgaaatca gcttctgatg tatgatgtgt gacaattacg atttcagcta actcatcatg 3008281 gcctttaatt ggcagctgaa ggattttttc aaagctcacg ccccgctctg agaacacaga 3008341 tgtaattttc gagaatgaac caacctcatc ttttacatga attcttaaaa actgctgtgc 3008401 ataaatgtca gacggcgatt tcatgttttt ctcatattgc ggtccgacaa agctgttgcc 3008461 ggttacacct aggcgcatat ttttcatgac agcgacgagg tcagaaacaa cggatgtcgc 3008521 tgtcggcatg cttccggctc ccggcccgta gaacatcgtc tcaccgacag cctcgccgta 3008581 tacataaaca gcgttaaact cattatgaac agcagaaagc ggatgatggt caggaagcag 3008641 tgtcggctgt acgctgacct cgattttgct gccgtcacgc tgagcaatcc cgatcagctt 3008701 cattgtatag ccgaggcgtt tgctgaagct gatgtcctcg tctgtaattt gggagatccc 3008761 ctttactttg acgtcttcca gatccacgtt catcgagaag ccgaggcgcg ccaatatcgc 3008821 cattttccgt gcggcgtcaa gcccttccac gtcagaagtc ggatcagctt cggcaaaacc 3008881 gagatcctgc gcttccttga gcacttcctc gtatgggctt ttctctttga tcattttggt 3008941 taagataaag tttgttgtgc cgttcacaat tcccatcatt tttgtaattc gatctgatga 3009001 gaggccttcc tctaacgtgc gcagaatcgg aatcccgccg gcaacactgg cttcaaagta 3009061 gatatcgcat ccattttcct tcgcttcggc aagcagctcg gagccgtaca cagccattaa 3009121 gtccttgttt gctgtgacaa catgcttttt cgatctcagc gcgtcgacca aatattgttt 3009181 tgtctgttca acgccgccga tcacctcgat gacgacatca acatctggat catcaatgac 3009241 atcatacact tctgtcgtga gcacttcctt cggcaaatct acttctctct ttttctctaa 3009301 atcttttaca agcacttttt ttatcgtaac cggacagccg acctgatgca taagcttatc 3009361 ctgatggtct tgaataattt taacgacacc gcttccgacg gtacctaaac ctaaaagccc 3009421 tacacgaatc gctttcaaaa aaactccacc tttcttttga ttgtcctctt ggaaaagaca 3009481 attgttaact caacacagac atataagtta caaacattat ataagcccgc tcctgttttg 3009541 acaagacatc attaggctga attttgcgaa tgtaaacgct taacgcattg atatgacaag 3009601 attctttatt ttctaattat ttttgtcaga ttttctcctc accttgagct gcctttgccg 3009661 agccagctga cgcgtggaac aaacagcttc tgcgcccgca tattcatgaa ttcctgcgct 3009721 gtattgagaa attgttcata acgcccacag tcattaagaa tgaagtcaag ctgttcttca 3009781 aaataatgct tttctgattc tgatgacatg taatagcttt ctacgatttc aaaataatga 3009841 agcgggaaaa gcagacggct gtataaaagg cgtttcgaaa atgaagacag cggtgtgact 3009901 tgctcgtatt cctgtaaaaa gagaaagccc tgctgattaa aatcttgtct gtgatgcaaa 3009961 aacgtatgcc tcatatattc agccaaatca cgggaagcgt ggtcaaacac ccaatccgcc 3010021 ggaatcctga tcaatgattc cggtgaccat gtatgccttt ccatccgctg atggcatatc 3010081 gttcctgaat cagcggcttg gggcttgtca tccagctcag tgtccactaa atattgtatc 3010141 gcgttttctg acagtcctaa ataatatgga aatgattcga tcattttttt atcgaatggc 3010201 tcatgcggag gggtctgaac ctttctctgc caaaatgctt ccagctgatc aattcgtttt 3010261 ccccacagat ccttccactg gccgattctt ccggccgcct tcacctcata tggatatcct 3010321 cggccttttc ggtgaaattc cgcaagctcc gctccaatgg agaacgccct gtttgaataa 3010381 gggggggccg ccttcagcag agcgtacgtt tttccctcat gttcaaatgt cagttcacct 3010441 tcttttgtaa agataaaaac cgaaacgtat gggtcacttt gttcttgtaa atactgactc 3010501 atgtaataaa gctccgccag ctctgtttct gagaattggg aaacggggac aatcagaaag 3010561 tatgaattag gcgtctgaaa gcattgatat gtgtgctggt acatggaaag ctgcctgatg 3010621 tgaatgccgt atttttcttt tattgtacct ttcaccatga tcacctgcct gttgaattag 3010681 ggctcatcac atcgtagtca tacacagccg gaattatgaa tacatatttt aatccgaaga 3010741 aggcgcaaga aaaagtcgta aacttctcaa gcattttgta taaactagta aaaaagattg 3010801 ggtgaagctg atgtcagaaa acgaacaatt cagtcagatg gaagctaaag caagagcacg 3010861 gatgaaggag cgcggcgttg aggtatcaga cattgccgag cttgtctttt ttctgcagaa 3010921 aaaatatcat ccggatttaa ccattgatga atgcacgctg aacgtcaatc gtgttctcgc 3010981 aaaacgcgag gtgcaaaacg cgattttaac gggcattgaa ttggatgttc ttgctgagca 3011041 gaaaaaattg tctgaaccgc tgcaaacgat gctggaaata gatgaaagcc tatatggagt 3011101 agatgaagtt ctggcatttt ccattgtgaa catttacgga tcgatcgggt ttacgaacta 3011161 cggttacatc gacaaagaaa aacccggaat ccttaaacga ttgaatgata aatcaaccgg 3011221 tgaatgccat acctttttag atgacatcgt cggagcgatt tccgccgcgg cttcaagcag 3011281 acttgctcac cgcgcgcggc atacagaata agggcaccct tttagggcgc ccttttttca 3011341 aatgtatgga atccattcag tcagagagtc aatggcgtga gtcggttttt ccatatcgtc 3011401 tgtcatatgt tctcttttcg ttacgcctgt gtgaacgagc agcgtatcca tacccgcgtt 3011461 aatgccggcc ataatatcag tggcgtagtt gtcgccgacc atgagtgttt cagacacatc 3011521 tgtgccgaga acgcgcatcg cctgctccat aataattgat tccggcttgc cgataaatac 3011581 aggctgtaca cctgtagata cggttaacac cgatgtcagt gagccgtttc ccggcaggag 3011641 ccctctttca gtcggaatcg caatatctcc gttagtggaa ataaagcggg cgccatttct 3011701 gattgccagg cagccaacag caaatttttc gtatgtaatg gaacggtcga tgccaacaac 3011761 gacaaaatcc gcgttttctc cgccaaatgt caggccgttt tcttcaatcg cctggcggat 3011821 tccttcctcc ccaatcacat acacagacgc gtcttttttc tgctgtgcaa tgtgctgggc 3011881 agttgccatg ctggtcgtga agacctgctc ttctgttgcc ggaatatcaa aagacacgag 3011941 cttgtccgct acctgcttcg gtgtgcgcga agagttgttt gtcacgaaaa gataaggaac 3012001 gccgcgatct ttcagcgttc tgacaaattc acacgcctcc tcgatttttt ccgtgccatt 3012061 gtacatcgtt ccgtctaaat caattaaata ccctttatat gttttcatat ccaacactcc 3012121 tgtggctttc cagttgttat ttaaacgcgg aaacaggtcc tagctctgtt tccaaatagc 3012181 ttctgatccg tttcgggaag tcctgaagag ctgtttgatg cgccttgatc agcctgtaaa 3012241 gctcgccgct gtcagcgagc agatactgtt gaaccaacgt tttgcggtag gcgatcaatt 3012301 ttttgagctc atcaccctct ttttccgtga caactttctc atcaacaagt atatccataa 3012361 tgtcgtcata gctgcccggg tcccgcataa taaagccgtc aatcatgtca ttgcctgtat 3012421 ccaaaatgca ttcgattaac agatggccta tacgctgaag tgccaattcc ccgatttcag 3012481 actgccagtc tgtttgtgag tcaaatagcg ccagctggtg ctcgaagaac cctagtgttt 3012541 tttcgatttt gcttctgtca acaaaataca tgacagcatc ccctttgtgt atatttattt 3012601 tctgatccgt ttcaagacaa aatacgcaca gccgaaattg cagtattcgt aaatatattc 3012661 atctaatgtg ctgattttcg tttcgaaggt tgccttttga ttctggtcgt caaagaagcc 3012721 cttgagcctt aactgaccgt atccccagtc tcccacaata taatcgtatt tatttaatat 3012781 atcggagtag cgggctttaa aagcctcttc gttgaagccg tctttgaaat tgtgcaccaa 3012841 ttcaaattcg gcattttgaa taagaatcat gatctcacct cttttttcac tcattcctat 3012901 cataattcat tgccccgtcc ccatcaattg ctaaagaata aatcatgcga tttggctacc 3012961 ctacacatga ggagggattg ataaatgaaa cgaaccgctg tcagcctctg cctgctgacc 3013021 ggactattat ccgggtgcgg aggcgcagga ttggataatg cccaaaatgt ccggaatcag 3013081 acgcagaatc aaaccaaacc cattcatgtg tcggaccgca acgaggcttt taacaggcat 3013141 aatgagaacg aacaatttgg ctatgtccgc tatcaaaaag aacaatttga cggagaacag 3013201 cagaaaacgc cggtgatgaa ccgggaagaa accgctcaca tgatatcaag tttaacggtt 3013261 cagctccccc atattcaaga tgctgcgaca ttggtgactg accgagaagc gcttgtcgta 3013321 tacaaaaccg attctaaaaa ccgggagctg accgccgatc aggtgaaaaa aacagcggct 3013381 tctgtgatac cgcgatacta tcacgtgtat atttccgata atccaaacca tatgcaatcc 3013441 gtcgaaaatt acagcaatct cggctctggt tcaagggata ttagagagat catgtcgggg 3013501 acgattcaag aaatgaaaac ctccccgcaa ggaagccctg tctcagagaa tgaaaatgcc 3013561 aatggagaaa cgcgtcagga catgaaaatc gataggaatg acaaaaacgc cagatgatct 3013621 ggcgttttgg cattatgctt gtgcttgacg ctttttagat gcttcgttta cttgttcatc 3013681 cgcatggtaa gaggaacgga caagcggacc ggcttcacaa tggctgaagc ctttttgcat 3013741 cgcgatttct tttaattctg caaattcatc aggatggtag tatttttgga ctttcaagtg 3013801 tttcttcgtc ggctgcagat attggccgat tgccataata tccacgttgt tcgccaagag 3013861 gtcgtccatt acttcaataa tctcttcttt tgtttcgccg agtccgatca tgatacttga 3013921 ttttgtcgga atgtcaggct gcatttcctt cgcacggcgc aaaaattcca atgaacggtc 3013981 gtacgtcgca cgcgcgcgga ctcttggcgt caggcggcga accgtttcga tattgtgatt 3014041 caggatgtct gggcgtgtat ccatcaaggt ttttaggtta tcgtagtttc cgcccatatc 3014101 agacggcagc acctcaattg ttgtgaacgg gctttttctg cggatcgcac ggacagtttc 3014161 cgcgaaaatg cctgccccgc catctttctg atcgtcacgc gcaacagccg taatgaccgc 3014221 gtgtttcaaa ttcataagcg cgactgaatc cgctacgcgt tccggctctt gcagatcaag 3014281 ctcagttgga aggcctgttt tgacagcaca gaaacggcat gctcttgtac aaacagaacc 3014341 taaaatcata aatgtcgctg tacgtctgac cgcccagcat tcatgaatat tcggacactt 3014401 tgcttcttcg catacggtat gcaggttgtt ttcccgcatg agttttttga gccctgtata 3014461 gttttcattt gtatttaatt taattttaag ccattcgggc tttctgaggt gttcgtcttt 3014521 ctttgccaat tcccatcatc tccaatatcc aatatactca atttctgaca cgaaacattc 3014581 tgaaaacgag aaaggtgcag gttttagttc tgcaacaaaa ataatgtttt tctaactaaa 3014641 gaaagtcttt tctttagaca ctttaacata ggaaaaattt ctcgacaagg gaagatgatt 3014701 actgacattt ttaagccggg ttgccgcaaa ctatgtgtat tcaatatgaa aggagattat 3014761 tttgtgaaag ttttgttatc cgctcttctt ctccttttgt ttgcatttga gccttctgcg 3014821 tctggaaaaa aactttcaga tccagtgctg tcgaaacgga tggaattata tcataaaatc 3014881 gaagctgtga cgcagatccc ttggtatgcg ctcgccgctg ttgatcaata cgaagaaaac 3014941 gtgcggagca accggaaaga tctgcctgaa aaggcgggaa tcatcagcat ctatataccc 3015001 gatgatatct ggagcgggcc tgaaaacccg aatccgaaag acgatgcgcc gttaagcatt 3015061 aaagtgtttg acggaatcgg aatggatggc gatggagacg ggaaagccga ggtcagcaac 3015121 gatgaagata tcttgtatac gttcagccaa tacttactgt cgtatggcac agatgaagac 3015181 aacatccgga tcgggctttg gaattattac cggcgtgatc agacagtggg gattatatct 3015241 gaattcatga agctgtttaa agcctacggc catattgatc tgggcgagca tgcattcccg 3015301 cttccgatca gaaccgatta cagctaccga agcacgtggg gagatgcccg cggcttcggt 3015361 ggaaggcgga ttcatgaagg tacggatatc tttgcccatt acggccttcc tgtcaaatcc 3015421 acatgttacg gcgtagttga aatgaagggc tggaaccgct tcggaggatg gagaatcggc 3015481 atcagggaca ttaacaatac gtatcattat tttgcccatc tcaatgggtt tgccaaaggg 3015541 attaaaacag gacaaatcgt tgagcctggc caagtgatcg gatcagtcgg cagctccgga 3015601 tacggcccgc cgggaaccgc cgggaagttc ccgccgcatc tgcactatgg catgtacaaa 3015661 gataacggaa gaaccgaatg gtcatttgat ccatacccgc atttgagggc gtgggagcga 3015721 tatgaatacc aaaaaaagaa gtaacaaaaa gccgcctctt caacaggcgg cttatttgct 3015781 gcttttttct ttttttgaat cggcaccgtt ttctttgctg ctcggaagct ggacagaagg 3015841 cgtgacaccc gagccgccgc ttccattata aaactgcggc acttcgccct gcactgcttt 3015901 aatcgataca ggaacattat ttgtgacgac agcggttttg ctggcaaatg gaatgatgac 3015961 cttcacttta atttcgacaa agatgctgat atcaataagt gcgttattta tgccatacgg 3016021 cttgattttg gttttgacat ctgtaaaagc gtcaccgatt aaattgaacc ggaccgggat 3016081 tttcggcccg aggtttccaa gaaggctgtt gccggttacc tgtcccagcg gaatgttgat 3016141 cataatgttt tcactggcgc cgctgtgtcc ggtatgggtt tccatctctt tcaaatgagc 3016201 ctgaagctgc tttgtcactt ttgttttcac actgtttaca acctgtgtat taaaatcgat 3016261 tgtcgttaag tttccgtttt catcagaatt catttgaaac atatctttca tattttcact 3016321 gtcagacata tagtcctcaa tcgaatcctg gatcacctct gtcgctatac gcttcgtttc 3016381 catctcgccg atgtccatta aaacaggttt gatcgagcca ttgatcatcc aaaggctgac 3016441 cgttgttgac aggataaaaa agacaacgga caggagcatc acgtaacgga aaggcaaagg 3016501 tcctctcttg cgaaaagggc cgcgatatct tggcaagaaa atcccccctt acatatcaca 3016561 atgtatgctt gtaagagggg acatagtaat agccggggcc aatttatttt atttcatcat 3016621 ttttaaaagc gcttctctgc cgctcatgcc gactttgatg ccaagatctt ccgcagcgta 3016681 cgtgacggat tctaaaggtg cgtctaacag ctggtcaatg gtgcggacac caactgcgcg 3016741 tcccgccacg atgccgcgct cctttaattt ttcattcagc agcgccacat caagcgcgcc 3016801 gcacataatg tatccgtgat cattggcgac ggccataaaa ttcgttttgg gaagctttac 3016861 tgtcacagct gtaaaaggct gtccttctat catgatcggt gtcaggttta ccacgtcaac 3016921 cactcccttc attcatcact ttatgatgaa gggcacagct tgttgtgggc tgactgcctt 3016981 attgtgcaag cttccaagca agcagatccc gcaaaaattc cggcataaaa tattcttttt 3017041 ctgcagcgtc gcgaatcaac ggaaacagtt tgccgagcgt aaacatatca agcaccgcaa 3017101 cggagtattg tttatgtttt tcaatatctt ccccgttcag tgtgatccga gtgacgtggg 3017161 tgatcccgtc atcgagccgt ttcgtttcta cctcaacgcc ggcatacacc attttcccca 3017221 tcacttctcc gcggaagccg agtcctttga tccggagctg ctccatttgt tcggaagcgg 3017281 catggacaat ggtttccttc agttcttctc ccgtcaggcg gacagccacc gggttgatcg 3017341 gatgcggaca gatgcggtgc agatccagct ttgtcacagg acctgctttt agcggaccga 3017401 gaatgacacc tgaattgacc atactgatgt ccgtctcgca ccattccttt aaggcgtatg 3017461 ccaaaagcaa aggcagctct gattcttcaa accacttcac ctcagcatct tgtgcaagct 3017521 ctgcaacggc atcggacagt ttctcctcgg cttcacgttc tttttcattg agaaacgctt 3017581 tagtttctgc ggattctcct gtccattccg ccatgttctg cacagaagcc gttttgctgt 3017641 tgatgcttcg ctgtacgctg tccaccgtga tttctacaca gccgacataa tgcccgtatt 3017701 tctcggcgct ggccagcagt accccattaa ccacttgtcc atcttcgagc aaatgatggg 3017761 tatgtgattc gaggattaca tcaatctcag gcaccgcttc agccactgct tgatcatcaa 3017821 gaatgcctaa atgtgacagc agaacgataa tatcagcctg ccctttcact tccagaatgg 3017881 tttcctttat gctttcaagg gcatccgtaa ctgtccatcc cagcttgtca tatacaggat 3017941 aatacggcac agttacacct aagaaagcaa tggacatacc gtttttcaat gatttgatat 3018001 ggtaaggcac cgcccaggac ggacggtttc catttttatc aaacaggtta gagacgatga 3018061 caggaaattc agcatgatca tataaggcag caagctcttc atgcggaagc gtaatccctt 3018121 cgttattgcc gatcgccgct ccatcaatgt gaaggcggtt taagagatcg acattcgctt 3018181 ttccgaatgt cgcctctgtc acgaattgaa aacgatcaag atgatcgcca atatcaaaaa 3018241 cgagcgtctc ttcgccgtct gactgatgct cttttctttt ctgctcgata taatctacaa 3018301 ttttcggcca gttttcaaaa tggctgtgca aatcatttgt atgatataag cggagcttct 3018361 ccttcataat atctctccct aatcgttcag ctgaaaatgc cttcataaat gagctggcag 3018421 ccgatcaaaa tcaatacgat ccgcatgatc ataacgatcg ttttcgtctg catttttctg 3018481 ttgatggcgg cgccaagctt tccgccgaac caagcgccgg gcacaagcgc gagggcgtac 3018541 agccaattga cgtgcccgga aatcatatgt gaaacagacc ctgtcataga agacaggaaa 3018601 ataataaaca tggacgttgc caccgcaacc ttcggcggaa acagaaataa cagcatcatc 3018661 gccggaacca tcagtgatcc gccgcctata ccgaaaagtc cgcctaaaaa accgacaaca 3018721 aaggcaatgg caataccgac agaggcctga tatgagtacg tataaggctc accggcatca 3018781 tcctgaaatg tccggataat tcctttgtgc gctttgttga ttggccgggc tttcgctttc 3018841 agcattaagg ataatgaaat cagaatcata aaaatgccaa accaaacgga aaacgagttt 3018901 gaattgaaca gctttgacac gtaagccccg atcatgctgc cgggacccga accgataaag 3018961 aaaatgagtc cgctcttata atcaactgtt ttatatttaa tataagccaa agttgaagaa 3019021 aggcccgtaa aaataatgac caaaagcgaa gttccaatcg caacctgcgg cgtcacatcc 3019081 tgaaacagct gcgtcactgt gcttaaaaac atcagagatg gcacaatgac aattccgccg 3019141 ccaagcccga tcagacttcc taccgtacct gcgattaatc ccagtacgac caaaatcaca 3019201 aacgacatca atcaaaacct cttttctaaa ataaatcgag ctgtctcgga gcaagtccgc 3019261 tgtactcgat atcaagcagt tcaagcatct gcttgccatt atccgcagcg tcaccgccgg 3019321 aattgttgtt gaacaggaca aaaacatcct tacattgctg ctgcaattca ttcaggtgct 3019381 ttttccaatc ctccagctcc tgttggttgt agcggtataa gtacctgacc tcccgccagt 3019441 ttttcccgcc atcaggcttc atccagccct gcttgttgcg tccgtgaaac ctgacgagcg 3019501 ttttgttttc atcggtcgcg cgcaacacgg tcggaacgct gccttctccg atttgcggtt 3019561 catcacagac actgtgaatc cagccttccg ctttcataaa tgaaagcgtc tgctcataaa 3019621 atggcggcga gaaccaggaa cggtttctga attcaagcgc gcaaggaata tctcccattt 3019681 ggtgcttaca ccatctcaaa taggcgacat tctccttctt gcagtcaaac cacggcggaa 3019741 attgaaacag caccatggcg agcttattgc tatgtaaata tggcgttaaa gacaccttaa 3019801 acgcatcaaa catctcctct tttgagtcaa agggaatttc gccgcgctga tgccctgtca 3019861 tgccctgata tgctttcacg ataaattgga aggtttcggg cgtttccttc acccactttt 3019921 cattattgcg cgccggctga atcgcgtaaa agctcgcgtc taattccacg atcggaaaat 3019981 gggaggaata ggcctgcaat tttttctggc tggccgtttt cggcggatag atgctgtcat 3020041 gatcccccca tcccgtcagt ccgatataaa tcacactcat tcacctctct tccagtttat 3020101 cacacgtgtt ttcaggtttc ctcggaaatg ctgttcatat ggcgggaaaa tgcctcacgc 3020161 aaatgctgat attgttcctc attcgtatct aaaaacgcct cttctcttga ggaaggaatg 3020221 tgctgatatt caataggcgc ctgaaactgc tcactcgtaa aatcgtacac cacaccattg 3020281 atgctgttat aaaaatgcca gctctcatcg actcttgttt tgaaaatcgt gccgccgaaa 3020341 tggtcttgaa tcaccaatgc cgtcacgccg cattggccgc atgacgggca ttcttccgtc 3020401 catttagagc tcgaatggcg cgaccaggat tgcttaagta tgtatttgac atgctccatt 3020461 gcctccgcct cctttaaaaa aagataccac gttgatgaga ttttaaaaac tagaacggag 3020521 gaaatcaaaa aacccggcgg taaaatccgc cgggcttacg aaggaacgac cagagctccg 3020581 tcaatttcag tgactttttc cccatcattg tacacgcacc ggcctttgct gtaagtggcc 3020641 gaaatgctgc agggaaatgt atgtccttcg taaatgcttt ttttatgctt tgcaaacatc 3020701 gattctcttg taacagtgta cggctccatg ctgacgagca cgaaatctgc atcacacccc 3020761 gcctcaagcc gccctttttt ctgaaggccg aatcgttttg caggggccgc cgctgtccat 3020821 tctgcgatgg tttcaaatgg aatctgatgc tcaagcgcca gttccagcat tcctaataaa 3020881 gtgaactgcc cgccgctgat tccgccccat gataaaaaca tgttatcctc ccgcttcaag 3020941 gatggacggc aaggggaatg gtctgaggaa accatgtcaa tgtccccggc aatgagcgtc 3021001 tcgatcagcg tctcttttga ttgccgtgac cggagcggag gcgcgcattt tgcgacagag 3021061 cccctttgcc gtaaatcgtc atggctgaac aagacataat gcggacatgt ttcaaccgaa 3021121 acatcaagac cttcctgttt cgcctctctg atcagccgga ccgctttcgc cgtgctgata 3021181 tggacaaaat gaaccggaca gcctgtcacc ttcgcatact gaatcgtgcg atacaccgct 3021241 tcaacttctg cttcctccgg gcgggaggcg gcgtacgcat ccgcatccac ctttccttta 3021301 ttggccaaaa ccatctgcaa gtagcttgtg atcgcgtcgc tttccgcgtg gagagcgagg 3021361 atttttcctg cagccgcgat ttctgccatg cctttgagca atgtccgttc atcaacagag 3021421 cggaactcat cagtgcctga ctttgataaa aacgctttaa acccgatcgc tcccgcttca 3021481 gccatcggac ggatgtcctc gatatggcct ggcacaaggc cgccccatag cgcaaaatcc 3021541 acggcagatt tttgcctgcc tagctcagct tttgcgagaa gatgctctgc cgtcacggtt 3021601 gatggaatac agttgagcgg catatcaaaa taggtagtgc aaccgcctgc ggccatcatt 3021661 tgagaacctg tttcaaaccc ctcccaatcc tccctgcccg gttcattaaa atgaacatgg 3021721 caatctatca caccaggaaa cacgtatttc ccgtctgcct ggatgatttc cgtcccgctt 3021781 gcttcaatgt cagaacctat ctcggcaatg acaccgtttt gaactacaat atcagcttct 3021841 ataacgccat ctggcgtaac tgccttcgca ccttttatca ccatatcgta agccatattg 3021901 atccccccat gtcaggatga cgattttcca tgtcagttta tgtaacacaa ccagttctat 3021961 tttcaacagt ttactgctac tatgatcgta ttacatcagc aaaaccgcta gaattcctat 3022021 tgaaaattat tcaccttaac caatgttttt atagaaaagg agaatgcgct atgaatattc 3022081 ttgatgtgat gaaaataccg gcttttgaaa acgccaattt aatcgctgga aaagcaggag 3022141 gggaaagaga ggttcagcat gtcaatatga tggacgctcc ggatatcgta gactttttgc 3022201 ataagaatga attgctcgtc accaccgcct atcacctgaa ggatcacccg catcaattat 3022261 ctgaactgat tcggcaaatg gcaaaacgcg gctgcgcggg cctcggcatt aaaacaaagc 3022321 gctatctgga agatatcccg aaggaaatca tcgaactggc cgattcatat gcgtttccga 3022381 tcattgagct tccggaacac atccgactcg gcgatattgt gaatgccaca ctcagccata 3022441 ttctcgatat gcgttctaac gagctgcagc aagccattta cgcgcacaaa aaattcacaa 3022501 accacattat gagcggcaag gggctgcaat ccctcctcaa aaaggtgtca gacatccttc 3022561 agcttcccgt gctgctgctt gaccagcatg ccaaaatgct gtctgcgtct catcagattt 3022621 cagttgagac cgaaaagctg aaaggcaccc tgaataccgt atccgggcca tttttcactt 3022681 gtttctctac aatctcagat cagaaaacat attctgtcct gcctatttat aatcacgaaa 3022741 aaaactgcgg ctacctgctg atacccgaca tggtgcaggc aggcgacaaa ggattgatcc 3022801 tcacgattga acaagcggcc aacgtcattt cctttgaact gctgaaggaa aatgcgctga 3022861 agcagttcag ccggcgggcc cgcaatgagt ttttcaacaa ttttattgag cggacctttt 3022921 cttcagatga cgaaatcaaa aaccgggcga aagaattcaa gctgcgctgg gatcaaaaat 3022981 acatgtgcat cgccggcaaa ctcgatcgca atgacgaatc aatcagcttt acagaaaatc 3023041 agctcgcttc cgacagcgta ttcgaatttc ttgaaggtga attatcagcc ttcccgtttc 3023101 cacctcactt ctttatgaaa ggaaatgtcg gcattattct aatcgaggcg acagacagct 3023161 ggagtgaaat gcacgcctcg gtgatcagct ttttagaaca gtttcaaaca caggtcagcg 3023221 ctcaatttaa acgaaccgtg tcctttggca tcagcaatat ctgccaaaag ctcattgatg 3023281 ttcccgacgc tttcacagaa gcttctgatg ctctgcaatc ggggcatttg tcaagaagca 3023341 ccgcatttat ccaggtgtat cacgccaaag atgtgcctga gcttctgcgc ttgctcccag 3023401 ttgaggattt gaagaaattt tacaactcca cgcttcagag cctcgctgaa aaacagcagg 3023461 aggatcaaag cctgcttcat acgctttccg tctatttaga gacacactgc caaatttcag 3023521 agacggcaaa gcgtctgtac gttcatcgca atacggtcat ataccgcctt gaaaaatgcg 3023581 aagagcttct ggggaaaagc ttaaaagatc ctgaaacaac gatgcgtttg cggcttgcat 3023641 tacgtatgca gcggctgatc agctaaagtt tgttacattt tcttacaaaa cgaatcgttt 3023701 ttcgtcactt tcagcaatca cacctgtctt tttcagctac tgtatccaat gacacccctc 3023761 gaccggaacg atattatgtt actaaagttc acatacaggg agggactata gtgaaaaaaa 3023821 gatcgtttaa ggtgtttaca cttagcctgc agcatgtgct cgccatgtat gcaggtgcga 3023881 ttttggtgcc cctgcttgtc ggcagggcgc tgaatgtaac aactgaacag ctgtcctacc 3023941 tattggcgat tgacctgtta acatgcggcg tcgctacgct tttgcaaacc ttgcgcggaa 3024001 catacatcgg catcgggctt cccgtcatgc ttggcagttc atttgtggcc gtcaccccaa 3024061 tgattgcaat cggcagcaat tacggcattc acgcgattta tggttccatc attgcggccg 3024121 gtgtgttcat ctttttgttt gcgcgttttt tcggcaagct gactgtgtta tttcctcctg 3024181 tcgtaacagg taccgttgtg accttgatcg gcctttcact tgttccgaca ggtgtgaaaa 3024241 atatggctgg cggcgaaaaa ataaacggca gcgccaaccc cgaatacggt tcgctcgaaa 3024301 accttcttct ctctgtcggt gtccttgttc tgatcttagt cctcaaccgc tttctcaaag 3024361 gatttgcccg aacactgtcc gttctgatcg gcatcgccgc cggaacagcg gcagcagcga 3024421 tcatgggcaa agtcagcttt tcttctgtta cagaagcacc gttcttccaa atcccgaagc 3024481 ctttttactt cggagcccct gcgtttgaaa tcggtccgat cttaacgatg ctgatcgtcg 3024541 gaatcgtcat tattgtggaa tcaaccggcg ttttttacgc aatcggaaag atatgcggca 3024601 gacctttaac tgacaaagat ctcgtcaaag gctatcgagc ggaaggaatc gccattctca 3024661 tcggcgggct gttcaatgcc tttccttata atacctttgc gcaaaacgcc ggcttattgc 3024721 agctgaccaa agtgaaaaca agaaacatcg tcgttaccgc aggctgtatc cttgtctgtc 3024781 tcggactgat tccgaagatt gccgcccttg catctgccgt tcctgctgct gtacttggcg 3024841 gcgcgaccgt cgtcatgttc ggcatggtga ttgcctccgg cgtcaaaatg ctcagcacag 3024901 cggatctcaa aaatcaatac cacctcctga ccatcgcatg ctcaatcgca ctcggcatcg 3024961 gcgccagcac ggcccccggg atttttgctg aattccccgc tccgatccgg attctggtca 3025021 gtgacggcac catcaccgga agcctaaccg ccatcttttt gaatctattt ttcagcttgc 3025081 gcgacaaaaa agaattaaca gcacagcaaa cagaacttcc ggtattagaa catacactcg 3025141 cattagaaaa agaggtgtaa aaaagatgaa ggaacagcac aatgccttac agctaatgat 3025201 gctggggctt cagcacatgc ttgccatgta tgcgggagcc attctcgttc cgttgatcgt 3025261 cggagcagcg atcgggctga atgcggggca gctgacgtat ttaatcgcga ttgatttgtt 3025321 tatgtgcggg gcggcaactc ttttgcagct ctggagaaac cgatatttcg gcatcggcct 3025381 tcccgttgtg ctcggatgca cgtttaccgc agtcggcccg atgatttcca tcggaagcac 3025441 ttacggtgtc ccagcgatat atggtgccat tatcgccgca ggactgattg tcgtcttagc 3025501 cgcgggcttc ttcgggaagc ttgtccgttt ttttccgcct gtcgtaaccg gatcagtcgt 3025561 catgatcatc ggcatcagcc tgattccaac ggcaatgaat aacctggccg gaggtgaagg 3025621 aagcaaagaa ttcggctcac tcgacaacgt gctcctcggg tttggcgtca cagcttttat 3025681 cttattgctg ttttatttct ttaaaggctt tatccgctcc atagcgattt tactcggtct 3025741 tatcgcagga acagcggctg catatttcat gggaaaggtc gatttttctg aggttttgga 3025801 ggcgtcttgg cttcatgttc cgtctctgtt ttatttcgga ccgccaacct ttgagctgcc 3025861 ggctgttgtc acgatgcttc tcgttgcaat tgtcagcctc gttgaatcga caggcgttta 3025921 ttttgccctc gctgatatca caaaccgcag gctgtcggag aaggatctgg aaaaaggcta 3025981 ccgggcagaa ggccttgcga ttttgctggg cggcttattt aacgcgtttc cctatacagc 3026041 tttctcgcag aatgtcggca tcgttcagct ctcaaagatg aaaagtgtca acgtcatcgc 3026101 catcacagga atcatactgg tcgcgatcgg gctggttcca aaagcagcgg ccctgacaac 3026161 agtgatcccc accccagttc tcggcggcgc aatgatcgtc atgttcggca tggtcatttc 3026221 ttacgggatc aaaatgctat ccagcgttga ccttgattcg caaggcaacc tgctgattat 3026281 cgcctcttcc gtcagcttgg ggcttggcgc tacaacagtt cccgcgttgt tttcatctct 3026341 ttcgggcgcg gcctctgtct tggcaggaag cggaattgtg atcggcagtt tgacggccat 3026401 tgcactgcac gctttttttc aaaccaaaca gccgaatagc gcagacataa aaacgtaaag 3026461 gaagatgcca atgttcacaa tggatgacct gaaccaaatg gacacacaaa cactgacaga 3026521 cacacttggc tctatttttg aacactcttc atggattgcg gagagatccg cagcactacg 3026581 gccgttttcg tccctttctg atcttcaccg caaaatgact ggcattgtaa aagctgcgga 3026641 tcgcgagaca cagcttgatt taatcaaaaa gcatccccgg ctcggaacaa agaaaacaat 3026701 gagcgatgac tcggtacgag agcagcagaa cgcagggctc ggcaaattag aacagcagga 3026761 atacgaggag tttctcatgc tgaatgaaca ctattatgat cgcttcggct ttccttttat 3026821 tttagcggtg aagggaaaga cgaaacagga cattcaccaa gccctgctgg caaggcttga 3026881 gagcgaacga gaaacggagt tccagcaggc ccttatagaa atttaccgaa tcgcccgctt 3026941 tcgtctggct gacatcatca ctgaaaaagg agagacgcaa atgaaaagaa ccatgtctta 3027001 tggcaaagga aatgtatttg cataccgaac gtatttaaaa ccgctcactg gagtgaagca 3027061 aatcccggaa tcatcttttg ccggaagaga taataccgtt gtcggcgttg atgtgacatg 3027121 cgaaattggc ggagaagcct tcctgccatc atttacagac ggagacaaca ctctcgtcgt 3027181 ggcaacggat tcaatgaaaa actttatcca gcgccatctc gcatcctatg aaggaacgac 3027241 aaccgagggg ttcctacact atgtagctca ccgattttta gatacctatt ctcatatgga 3027301 cacgatcact ctgactggcg aagacattcc gtttgaagca atgcctgcat acgaggagaa 3027361 agagctcagc acaagccgcc tcgtcttcag aagatcgcgt aatgaacgaa gccgctctgt 3027421 gctgaaagca gaacgaagcg ggaataccat aacgattaca gagcaataca gcgaaatcat 3027481 ggatcttcag ctcgtcaagg tgagcggcaa ctccttcgtc ggcttcatcc gggacgaata 3027541 tacgactctc ccggaagacg gcaaccgccc gctgtttgtc tatttaaaca tcagctggca 3027601 atatgaaaat acaaatgact catacgcttc tgatccagca cgctacgttg cggctgaaca 3027661 agtccgcgac ttagcgagca ccgtttttca cgagctcgaa accccttcaa tccaaaacct 3027721 aatctatcat atcggctgca gaatattagc gaggttcccg cagctcactg atgtcagctt 3027781 ccaatctcaa aatcacacgt gggatacggt tgtcgaagaa atcccgggct caaaaggaaa 3027841 agtctacacc gaaccgcgcc cgccatacgg tttccaacat tttaccgtga caagagaaga 3027901 cgccgagaaa gaaaaacaga aagccgctga aaaatgtcgg agcctgaaag cctgatggga 3027961 aaactgacaa cccatatttt agatttaacc tgcggcaaac cagcggcgaa cgtaaaaatt 3028021 ggattgaagc ggctgggcga aagtattatg aaagaggtat acactaacaa tgacggcagg 3028081 gtcgatgtcc ctctgctggc tggtgaagag ctgatgtcag gagagtatgt gatggaattt 3028141 catgcaggag actattttgc gagtaaaaac atgaacgcag ccgatcagcc gtttttaacc 3028201 atcgtcaccg tccgttttca gctagcagat ccagatgcac attatcatat cccgctcttg 3028261 ctgtcgccgt ttggttatca ggtgtatagg gggagttaag aaggaagccc gcctcaccgg 3028321 cgggcttctt tttgcacttc aattaacttt tgatcctagg acagtacttg aagtgatccc 3028381 cacacttagt gaaacaacag ctagaataaa cattcaccta tatttttcag gataattgcc 3028441 tacgagaaaa ataccctgta gtcctttcat ttataaatcg aggtttcaaa ctaataagtc 3028501 agctcttagc agccgagctc ccttctccaa tcctataaac agaccgcgtt ttttctcgaa 3028561 aaaatactct gaagacaatt gctgcgtttt taatagtttt gataacgcgt tctctcttac 3028621 acctttagac aaaatattca ttttttcttt tttagactta aatctatgtc gaaaataatc 3028681 gttggcatat cttatcctat ctccactaaa ggaggtgaca ttatgggatt ctacaattct 3028741 ggtggataca gtggaaactc tggttactca aacggtttcg ggagctcctt cgctttgatc 3028801 gtggtgctat tcattttgtt gatcattgtt ggagcagcta tctttaatta ttaagtttaa 3028861 ctttccttgc ctccgccgta tccaacacct ccctgtccga cagacgccat aagaagtttt 3028921 tatggcgtct ttgctatgtg ttcactaatc tttttgtaat ccagaagctg tcaagttcta 3028981 cgagatttat cgtgtgtttt cccacaacgc ttctgcgtct tgatcgcgct gtctgactga 3029041 ggctaaaaaa gtccggcttt taaaagccgg actcccgtct acccccgttc aactctcttc 3029101 taatcctgca agctgaccgc ataatcccgc catacccggt acaccggcac aaattccccg 3029161 ccagcccttc ttctatatct ttgtcagaag gttgaggggt ttcccgaaac aatgctttaa 3029221 gcgcaatgat cattcccggc gtacagtagc cgcattggaa gccgccttct tccaggaaag 3029281 cggtttgaca catatccagc tcttcttttt gaagcccctc gatggttgtg atggaatggc 3029341 cgtctgcttg ataggccatc gtcatgcacg cattggccag ttttccgtcg attaaaatag 3029401 agcaggctcc gcagcggccg attccgcagg acacctttgt cccggtcagc tgaaattcct 3029461 ttctaagcag gtcactcaga tgtgtcgtag gaacggcagc aacctcccac gcctgaccat 3029521 tcacggtcat ccggaactgt tcctttttta caggaaatgg cccggcctct tttatgtcca 3029581 ttgcttcagc ccctttctgt cgatcgcttc aagcaactct tctcttgaaa ttggcagctt 3029641 gtttatccag catccgaccg catcatgtac tgcctttaca atcgccggag tgatggcgat 3029701 tgttccgatt tcaccaacac cgcgcggtcc atatacgtct cccttcatta agtcttctat 3029761 tgcaatcagc ttcatgtcag gaacatcttt gattccggga atcaaatagt gatcgagatt 3029821 ttccgcagca taacggccat ccgtcatttt cgcttcctcc atcagtgtgt agccgagtgc 3029881 catggcagcg ccgccttcaa tttgacctcg atatccctgc ggactgacaa ccggacctgc 3029941 cgcaatagcg tgctcacaat ctatcaattt gacatcgcct gttaacagat ctacctccac 3030001 ctcaacggca gccgctccaa atgagtagag gaaatggccg cccaccacag gatcaggcgt 3030061 tgttggaaag tcaaaggccg tttcctctgc caaagggcct ttttcagcca gctccttata 3030121 cgtcaccacg agcgcctttg tgtttttgtc acgcaagcct gcagcgccgg gaataagatt 3030181 ttccgctgaa cagccgctcc attctgccgc ccgttttttc aactgagcta gaaacggctt 3030241 cttcaaacgc tggatcgcgt gccacaccat gcttgtgccg cgggatgctg tggaggagcc 3030301 tgacttcggc acttttgcgg tatccccaat aacaatggaa atatcctctg cggcacaacc 3030361 cagctcctcc atgacaatct gttcaatcgc tgctagaatc ccctgtccgc attcttcaaa 3030421 tccaaacgaa gcagtgattt tgccttcact cgaaagagac aaacggcctc ctgccgcatc 3030481 cattcggcca aaccccagcc cgccgccgtg cattgtaatt gccgctcccg tgcctctttg 3030541 cagatacccg cagttccggc ttgttttttt aagaatggga gatttagata tggcattcaa 3030601 cacctgtgcc gctccgtcag ttggtgcaat tcgatgctca agcggcccca agtcatgcgg 3030661 ttttctgata ttttttcttc tcagctcgag cgggtcgatg ccaagcatgc cgctgagacg 3030721 atcgagatgg gtttcgagtg caaatgtgat ttggttgccg ccaaagcccc gaaattcccc 3030781 cgccaccccg ttgttcgtaa atactgatat tccttcagtc cggatattcg gaatacggta 3030841 cggccccgcg gcatgctcga cagaaaaatc aagaacagcc ggtccgagcg tagcgtaagc 3030901 gcctgtgtcc gccacaattt tcacgtcgtg cgccaataga tttcccgaat gatctgcacc 3030961 cgtttttatc gtaatcttca tcggatggcg cttaatgcca gaacgtacag attcctttcg 3031021 tgtctgatga attttgacag ggcgtccgct tttcagggcc aaaagcgcag catacggctg 3031081 aatattcagc tcatccttcc ctccgaacga gccgcccatc ggacttgaca caattctgat 3031141 cttctcttca ggaatatcaa aaatacgggc aagctggaaa cggtctttat agccgtgctg 3031201 ggttcctgca tacatcgtaa aacccccgtc gtcttccgga acggctacac ctccctccgt 3031261 ttccatatac gtatgcatct gccgcggcag ctcataggtt tcttcaaaga ctgtgtcaga 3031321 tgcttgaaac ccttcttcca catcaccgtt tgaaaaaaat gcgcggtgca ggatattccc 3031381 gtcctcatgc agtctttgcg cattcggccg aagcgctttt tctggtgaat ccatgacttc 3031441 cagctcttta tactcaactt gaatcagctc cagcgccgct tccgcgattt cttccgtttc 3031501 cgcagcaact gcggcgatcg catccccgac ataccgcacc ctgtcctcac ataaaaccgg 3031561 ctgatcaggg atgacaatgc caaatcggtt taagccggga acgtctttat gtgtgacgac 3031621 ggcctgcacg ccttccattt tctcagcttt tatggtgcaa accgacacaa tctctgcatg 3031681 aggataagca cttctcagca ccttgccata cagcattcct ggaaagctga gatcggtcat 3031741 atatttcaat tcccctgtga ccttacccct tccatccggc ctgactcttg acggtttgtt 3031801 gatgatcatt tattcccctc cctcagccat cagctctgcc atgatgacgt tggcagcggc 3031861 tttttttctg tatgccgctg acataaaaac atctgaggaa aacggcagct catggataag 3031921 tgttttgtac agctcatgcg ggtcccaccc tggtgccatc catttcgctt cgctgtccaa 3031981 taatctccta ggagtgatat cggcatggcc agcggcgagg cgaatgctgc cgtctttcaa 3032041 aaaacgtcca gctgcaacag cagccgctcc ggtaaaagcc tggcgccttc caagcttgtg 3032101 ataaaataca cgctctccct ccgcccgcgg gatgatgaca cgcgtgacga tagccgttct 3032161 aaagtcttcc tcactgagcc aagcgccaag cggcagcctg attagctcct tttgatatac 3032221 gataagctca gcaccaagca caagcagaag cggaatgaaa tcaccgattt tactcgctat 3032281 gttgccgcca atcgtggcac ggctgcgaat ccccggtgca gcgacagcgg aagcagcgtc 3032341 actgaaacag ctaagcgctc tcttaatcaa agggttcttt ctgcattcat tcagtgatgt 3032401 gagccccccg atcgacacgt gggtgtcact ggtgctgatc cctcgcattt cgtcaatccc 3032461 ttcaaggctg acaaggtgct gtttcggtag agttcctttg tcccactgaa gctgaaggag 3032521 cgtgcttccc gatgcggcac acacatccgg agcaagcttc tctaaaagcg aataggcctc 3032581 atcaagcgct gccggtctcc ataattgaat attcatcctt gcttttgtca cttggccgtt 3032641 caagacatcg ccctccttac catgtcatat tcctcgggtg tatcaatatc gtccaactca 3032701 ccgctatcct ttgcctccaa aaccgctcct gctccaagct gtccgctttt caggagcctg 3032761 cgagcccctt catctccctt taatcccttt acataaggaa aacatgtcga cgagaagtag 3032821 attggcgggg tgaacgcccc taaaaacgat gacacggcaa atgactcagg agccagagcc 3032881 acaagggcat tgagatgatc gacggaaagc tgaggctggt cggctaacaa aatgacaatg 3032941 ccgtccgccc ccatgctttc tgcttttctc accccgctgc tgactgaatg cccctgaccc 3033001 ttttctgcgt cttggcaaac gtgcaggctc cagcgttttt gaaaaggcgg agcgtgatac 3033061 ggcgctccta tccactcaag ggaggcatgt tctgtccgct cgacgaccag cacgtgatca 3033121 aggcgggacg acagagcagt tttcaaggaa agtgagccta tgttttctcc ttttagcggc 3033181 aaagccagct tgttttgtcc cattcttctg cttttgccgg cagcgagaaa cacgccgatc 3033241 agataggggc ttctcataca accgccaccc gttttcttgt ttgaatgatt tctgcaacta 3033301 cacttaccgc aatttcctcg ggaccttccg caccgatttt cagcccgacc ggactgtaaa 3033361 agtgagacgg aggatgtttt ccgctcagca gccgtttcgt gcggtttgcc gaacccaaca 3033421 gtccaatata atggaggttt tgagaaaata agaagttgat gatcgtttga tcgtgctgat 3033481 aatgatgggt tgccacaaca gctgcatcat gcggaaaaaa ttgaaattcg ctaagcattt 3033541 gttccggaaa agcggtgatc agctgatccg cttttggaaa aagagaggat gtacaataag 3033601 cgggccgcca atccgtcacg ataacagaaa accctgtgtc agccgccaaa ttggccagcg 3033661 gtacattatc cggtcccgcc ccaaacagaa tgagacgcgg cttcggttca attcgctgaa 3033721 taaacatgtt agtggtttga tcgaaatgcg gtaaatgaag cgttgaaaca gtacgttgaa 3033781 tatcttgcag aggcgcgtcc ggccagttcc caaaatgtcc gttctccgtc agaaataaat 3033841 aatgggagga ttcaatcttt ataacggaag tgacagcttt gcctgaatga aggcagtccc 3033901 tcactttctc atagtgccgc cttttttcct gagtgattcg ctctgcatga acatgaataa 3033961 tgccattgca cccggctccc atgccccaag aaagatcgtc ctccgaccgc atgtcgtagg 3034021 gaatcagcgt tgatgtgagc tgatcgccca gcgcactgat tctttggaat acatcttctt 3034081 ccacacaccc gccgctcagc aagccaatcc gtctgccttt tttcttaaag agcatagagg 3034141 cgcctgcttt tcgatacgcg gagccttcaa cttgaacaat tgtcgccagt acagcctcct 3034201 cctggtcttc caggagcgca tctaacatcg tgtgaaaatt ccccaatgcc gcatcctcct 3034261 ctcgaaaatt gccgtgagaa acaactagtt cagcgtgatt ttataggtaa cttgtataaa 3034321 gaatagacga tggaagaaaa aatgactcat gatttgtcag aaaatgaaac acatagaaag 3034381 aggatttgta aaaagagtca aacgaagaaa atcagattgg agaaaacacg aaatcatatc 3034441 gttaaaaagc ttgcggagtt ccgcaagctt ttctttacac cgctgcctgg cggccagcgt 3034501 tttcatacac atccagcgct gcttggagcg cttttcctgc ttcgattcct gcgttatgtc 3034561 tgagaagcac agcctctaac ccggcaagca cgaatagcac gttttctttt ctgcagctgt 3034621 accccatcgt gccgatcctc cagatcttcc ctgcaagcgg gccgaatgag ctggcgattt 3034681 caatgccgaa ttgtgccagc agcatgtcac ggacagactc gccgtcaatg ccgccgggaa 3034741 tttcgacaca ggtgacaaca ggcattttgc agctgtcatc tccaaacaat cttagcccca 3034801 ttgcctttat ccctgctgct aatgcggctt catggtgccg atgccgctcg aaacgcgtct 3034861 caagaccttc ttcaagcacc agtctgactc cctcacgtaa ggcgtacagc atcgtcgtcg 3034921 cttctgtatg atgattgagc cgtctttcgc tccaataatc ctcaagctgg ctcaaatcaa 3034981 agtagttgct tgtaattggc cgatttcccg aaagtgctgc cctgtcagct tgtgtcgcaa 3035041 tcccgcgttc cacctttttg cgagctgcaa tcacgtccgc cacccgctca ttatatgtaa 3035101 tcggcgccat tcctgaaggc acagacaaac atttttgcgt tccgccgatg gcagcgtcaa 3035161 tcttccattc atcgacttta acctcgcagc ccccaatcgt tgcgactgca tcgacgataa 3035221 acaatgcatc ctcggtgcgg caggcttcgc cgatggcttt cagcgggtga atccgtcctg 3035281 tcgatgtttc tccatgcacc atggccacaa ttttcggctt cacttttttt atctcccgta 3035341 tgatgtcctc cgggtcaaaa accgttcccc attcgcactc cagcatatga acatttgccc 3035401 catatcgctc ggcgatttca gtcagcaaat aaccgaaacg gccgtaaatg ggaatgagca 3035461 catcatcttc cggctctatc acactagcca gcactgcttc aattcccgcc cgtgaagtgc 3035521 cgtcaatcgg gtatgcccag cggttttttg tttggaacag ctcccgaagc atctccatcg 3035581 tttcattcat aatacctgta aacgccggat caaattggcc gacaaccggg gtgctcatta 3035641 ctcttaatac acgcggatca acctcaacag gccccggtgt cataatcgtt cttaacgggg 3035701 tgcataattc tcttctgcct gacacagcca ttcctccttt atcagtaagc cagtttgtat 3035761 aataaatcag tcagtgcgcg gacgccgatc tcaagctgtc tggctgacgt atattccttc 3035821 ggtgagtggc tgacgccgcc tcggctcggc acaaacagca tacaagcagg atagcgcctt 3035881 ccgatcattt gcgcgtcatg ccctgctccg ctcaccattt cctcacagct gaagccgttt 3035941 tctaatgctg tttcaaaagc cgcagccttc agcctttcgt ccatcggcac aggctctatc 3036001 cgcatatatt catcaatcac agcgcgaatt cctttttgta ggcaaatgcc gttgatcaaa 3036061 gcaaccatgt cttgatgaaa ctgttccagc acatgctgat gctgatggcg aatatcgatt 3036121 gaaaactgga cgcggcccgg tatgacattg gctacattgg gctctgccgt tatttttccg 3036181 catgtcagac ggagctcatc cggcagctca tccgaccgca gcagcagctc atgaatgata 3036241 cggctgctgg ctgcgagcgg gtccttgcgc catttcatgg aggtggttcc tgcgtgattg 3036301 cattctcctt cgagcgtgac gagatatcgt ctctgccccg caatacttgt cacgatgccg 3036361 agatcccggc ctgacatttc caacgtcttc ccctgttcaa tatgcagctc aacaaacgcg 3036421 ctgatatctg tcctatatgc tgactgaaac acacctttgc caaaaccgct ctcatgcatc 3036481 gctgtttgga gggagactcc cgactcgtct cttggctctt ttgcatcttg ttctgaaaaa 3036541 acacccgtca tattccccga cccccaatag gtcattggaa aacggctgcc ttcctcctca 3036601 cataaggaga ccgcctcgag cgtttttttt ggcgctccgt atgtttcctt gagctgcttt 3036661 aacgcgagca ttgccgccag aacgccatag gcgccgtcgt attttcctcc attgatgaca 3036721 gtatcgatat gtgaaccggt tacaatgact tcatccggag actgggtgcc cgaaagcctt 3036781 ccaaacacat tgccgacatc gtcgaatctt gtttcaagcc cgaaagaaga catttccgtt 3036841 ttcacagcaa gctgtgcgtc catccactct tttgtgtata aaagcctcgt tacgccgcca 3036901 tccgcagacg caccgtattg ggcgagccat tcaatataat ctgtgatgct gttttttact 3036961 gaaagcttct gcttttccat gtactccccc ctctggccgc tatggtgact tcattataga 3037021 aggagcaaca tgatagttca ttgacagatt aaccaaaaaa acgtttattt tttagccaca 3037081 gtatccatcc agcaaccaga tacaccctac atgtcacaac tattttgatg taaaggtcaa 3037141 aagaaaacac ggtaaggaag agagccagca agagcgaaag agagggtcaa aatgcctttc 3037201 atatgaacaa gctaagctgg agaggcgatg ttcgcggaac ggatgaaaac agaaatgccg 3037261 gcagcccgca aaaacaggac ctaaagatat ggaaacagga gatttccgcc tcctccaaag 3037321 ggactaattt acaattttaa tgaaaaatat acaaaatgac acttctatcc tttatttcaa 3037381 ttttagataa tagatatgat ctgataaaag gagggcaagt gatgacaaaa aaagcatggt 3037441 ttctgccgct cgtctgtgta ttactgattt ccggatggct tgcgccagca gcttcagcaa 3037501 gcgcgcaaac cacattaagc cttaatgacc gattggcgtc ttccccttca ggaacgggaa 3037561 gccttctctc attagccgcc cccgctgcac cctatgctga cacagatacc tattatgaag 3037621 gggctgaagg taaaacagga gactcgctaa aaagcaccct gcaccgtatt atcagcggac 3037681 acacgatgct gtcctacagc gaagtgtgga acgcgctgaa agaaacggat gaagacccaa 3037741 gaaatccgaa taacgtcatc ctgctctata cgaatgaatc gcgttccaaa aacctgaacg 3037801 gcggcaatgt cggcgattgg aaccgcgagc atgtctgggc gaaatcccat ggcgattttg 3037861 gtacgagcaa gggacctggt actgatattc atcatttgcg cccggctgat gttcaagtta 3037921 acagcgccag aggaaatatg gattttgaca atggcggcac tgaatatgcg aaggcacccg 3037981 gaaattatta tgacggcgat tcatgggagc cccgcgatga tgtgaaaggc gatgttgccc 3038041 gcatgctgtt ttacatggct gtccgttacg agggtgatga cggctatcct gatcttgagc 3038101 ttaatgataa gacaggcaac ggctcagctc cttatcatgg caaacaatct gtcctgctcg 3038161 aatggaataa gcaggatccg gttgacgacc gcgagcggaa aagaaatgaa atcatttatg 3038221 aaaaatatca gcacaaccgc aatccattta tcgaccaccc tgaatgggcg gatgagattt 3038281 ggccgtaaga aaaaggtgct ccttttgagg agcacctttt tctaatacac agcctcttcc 3038341 gtttccgcat cgaaaaagac gacgtggtcc attttcactg agagctggat tgaatcgcct 3038401 gcatcgattc gcgtgtttcc gtccaggcgg accttgagcc gctcgtcccc agccatgaca 3038461 tgcactatga gctccgagcc cagattttca ttcacttcca cgttcgcttg aaacactgaa 3038521 tcaaacaact ggtcatttcc tgtcatttgt gtgatgtgct ccggccgtac accggcaatc 3038581 atctgttctc cggcatatcc cttttccttc agccgctttg ctttttcttc aggaatatga 3038641 agccggatcg aagaatttgt gaaaaacagc tcgccatgct gctgttctat gatgcctttc 3038701 aaaaagttca ttccgggaga gccaatgaag cctgcgacaa acaaattggc cgggtaatga 3038761 taaatgtcat gaggtttcgc cacttgctga atttcccctt cattcatgac gacaatccga 3038821 tctcccattg tcattgcttc ggtctggtca tgcgtgacat aaatgatcgt tgcctctaat 3038881 cgctggtgca gcttgctgat ttctgtccgc atcgtcactc ttagttttgc atccagatta 3038941 gaaagcggct cgtccattaa aaagaccttc ggctccctca caatcgacct gccaagcgcc 3039001 accctttgcc gctgcccgcc ggagagcgcc ttcggttttc tcttcagcaa atgttcaatt 3039061 tctaaaattc tggctgccgc atgaacccgc tcggcaattt cctgtttcgc catctttctg 3039121 agctttaatc caaacgccat attatcaaaa accgtcatat gcggataaag cgcatagttc 3039181 tggaatacca tcgcaatatc acgttctttc ggcggaagat cattgacccg ctccccatca 3039241 ataagaagat ttccttcaga aatgctttct aatccagcca ccatccgcag cgttgttgat 3039301 tttccgcatc ctgacggccc caccagcacc aaaagctcct tatcctttac atctaaatca 3039361 aagtccttca cggttaattg tgagtgatat gattttttga cgtgttcaaa tgttaatgaa 3039421 gccatcagaa aagtccccct atcttttgac ccgttatttc gtcactggaa acaacttggt 3039481 ctttctgtta tttttagagt aatcgattcc catttttgct atatttctaa aataaaaaat 3039541 gtaaatttgt attataacgt cataatacat tataatataa ataataggtt aaaaggaggc 3039601 taccctttgt taaacaacgg aagttctaca cctttataca ttcagctaaa acaaatcatc 3039661 actgatgaca tcaaaaaggg cgtgtattcc ccaaccgcca agctgcctac cgaaaacgag 3039721 ctttgcacca agtataacgt cagccgcatc accgtcagga aagccattct cgatttagtc 3039781 gaagaaggct atctgatcag gcagcaggga aagggaacgt tcgttaaaag ccctaaatta 3039841 aaacgagagc tgatcgctgt aaacggctac tcggaattta tggaatcaac cggcaaaaaa 3039901 ccgaagcatc atgtgctgtc ccatgacatc attccagcgt caaaacccat cgccgaaaag 3039961 cttcaaatcc aacccgagag ccctgtggtt gaattaaaac ggattttata taatgatgat 3040021 cagcctctca cctttgaagt gacgcattat ccgcttgatt tgtttcccgg cattgatacc 3040081 tttattgctg acggcgtctc catgcatgat attttgaaac agcaatacaa agttgtaccc 3040141 acgcacaata cgaagctatt aaacgttgta tatgcccaac aggaggaaag caaatacctg 3040201 gattgtgata tcggggatgc gctgtttgaa attgataaaa cggcttttac atcaaacgac 3040261 cagccaatct attgctcatt gtttttgatg cacacaaacc gtgtcacttt taccatcaac 3040321 agcccctaca cataacaggc ataaaaaacg agacactgct tatagtattc tcgttttttc 3040381 actgcttccc ccgtcctcca agcgataagg atagccatag ccgaaagctc cgtacacacc 3040441 gcaagttttc gcagccgttt cagcagcctg gcgcaaagca tacgttatat cctgcttcac 3040501 gcaaaaggca gtcaaaaagc ctgctataaa agaatctccc gctccaagtg tatctattat 3040561 atcagcttcc acaatcggct gatgatagac tcgatcaccc gcagacagga ttgctccttg 3040621 gccccctcgg gtcatacaaa ccattttggc tccgtaccca tgagctgttt tggcaagctc 3040681 accgcattcc gactcactca aatcgcttcc tgaaaaaaac gcatacgtca cataaggaca 3040741 gaccctcctc aaataatcat cctcccgatt ggttgaaaaa tcaaatgaga ccgggaccag 3040801 cccgcacagc tgcggaagat cgttctcaag cctgctgtac acgctcgtat gcagcagatc 3040861 atgcccgctg ataaaagata catctttctc ctgaaacgcg aggcgaagcc gggactgaat 3040921 gccgccttta tttgatctga caaaaatgcg gtccccctgt tcatcaaggg tgacaatcgc 3040981 catcccgttt tctccgtgcg cctggcggat ataatctgca ttgacctgct ccagcttgag 3041041 aacgttcaac agatgcgccg cggcttcgtc attgccgacg attccgatat aggaagactc 3041101 atgcccgagc cgcttggcaa gcacagcaac gtttaaggca tttcctcccg ggtaaaatgt 3041161 ttcttgatcc tggtagtaat ctacaacatt atctccaacc gcaatcaatt tcatagcgct 3041221 tcctccttta tccttttaca ctgccgcttg caatcccgcg gacaaaatat ttctgcatca 3041281 ataaaaatag aataataatc ggcgcggctg aaatcgttaa ccccgccagc aggacgcccc 3041341 agtctgtctg cagcgcgtct ctgaactgca tcagcccggc tggaatggtc cgtaaattct 3041401 catcatctat gaaaataatc gcaaacataa actcattcca tgtatggtaa gccgtcaaaa 3041461 tgccggatgt caccaaaatc ggcacgctca ttggtaagaa aattctgaaa aatactccaa 3041521 aacttgtaca cccatccaaa taggccgcct cctccaattc ttttgaaata gaaagaaaat 3041581 aagagcggat caaaatgatg gtgaatggga tccgataagc cgcatacggc aagattaacg 3041641 cccaatacgt attgtacagg cccagcgact gaataataga ataaagcggc acaagactga 3041701 cctgcggcgt cagcatcaat ccgccaagac atagcaccaa aaagaatcct tttcctttaa 3041761 actcaaaccg ggaaaggcca tacgctgccc atgcactgat aaagacagtg atcacacacg 3041821 tcagcgccgt aacgatgaca ctgttcataa aataagaaga aatcccctga ttccaggcgg 3041881 aaacaaaatt ttccggatgc cacgaagacg gcagcgacca gctgtgctca aaaatatcgt 3041941 cagagttttt aaaggcgctc atcaccatcc agagaagcgg ataggcaatc gcaatcagat 3042001 aaagaaacag aaaaacccac acagacgttt ctccgatata ccattttcgt ctaggcttat 3042061 ctttcacctc aatgtgctgg tcaggcaccg gctccaatct gaacgaatct gtcttcttct 3042121 gaggcagcat cagttactcc tcctttccgg ttttaaagaa cttcatttgc atgagcgata 3042181 atgcaagcgt aatgattaac acgacagtgg caatcgctga ggcgtagccc atcatatcct 3042241 ttgtaaaggc gcttttatat aaaaacgtgc tcaagacttc tgacgctttt cccggcccgc 3042301 cgcctgtcaa aatgtacggc tcattaaaga ccgtaaaggc tccggtcagc gtcatgacca 3042361 ccgcaacaaa agacatctct ttcgtctggg gaacagtaat atgaaaaaac tgctgaattt 3042421 tacccgcgcc gtcaagccgg gccgcttcat acagttcatc cggtattttt tgaatcgaca 3042481 cgatgtacag catcgcaata taaccgacag attgccactg ggacacaaaa atgacagaaa 3042541 gcatagctgt gctgtcatcc ccgagccagg ccctcgtcag ctgatcaaga ccgatggcct 3042601 gaagcagctg attcaaaagc cctgtctccg gattgtaaat aaaatcaaac aaaagcgcga 3042661 tcaccgtcat tgagatgaca accggcaaaa agaaaacggt acgaaaaaac ggcgaccatt 3042721 ttctgaccag cttatcctca agcaccgccg ccaaaatcaa accgccaaat acctggcata 3042781 caattgagat cactgcataa agcacattat tggtaagtgc ctgatagaag acaggatcat 3042841 gaaataattc aacatagttt tttaagccga taaacgtttt ttccggagaa aatgagctcc 3042901 actgaaacag gctgaggaat acattctcaa aaatcgggat ataaacgaaa agtaaaaaaa 3042961 cgagagcggg caccaaaaac aaatagggga ttattttatt ctgattgacc aagggtatct 3043021 catctccttt ataaaaagaa aaggtgcgaa gcttcacctt ttctttgatt tattcagctg 3043081 acgccctcac ctgctttgct gccttttgaa cggctttcat cacctgctgc ggtgtcatgt 3043141 cgccgccaag catttgctgg acgcccgtta ggtacgcatc tgcgacttca acatcgacat 3043201 ccatatcaaa ccatggaacc attgatttgg catcaacaat atgctgaacg gcttcacgct 3043261 gaatggctgt tgcattttct tcagtagccg taccttgcac tgcactgtat ttcccgacat 3043321 ctttcacgag cttttcgccc attcttttcg acgtcaagaa ctgcaaaaat tccatcgctt 3043381 ccttcggatg ttttgttctt gaggagatca tgaatccttc cggcgctccc gttaacgctt 3043441 ctgaagatcc tttctgcccg ctgatttcag gaaatgggaa catcccgaga ttaaccggtt 3043501 caaccagctt gatttccgct gtttccgcat atatcatcgc cgactttccg ctcttaaatt 3043561 gctgtctcac atattcgtgg tcgacggagt ttacatgttt attaaagtaa ggcatcagct 3043621 cttgaagctt ttcaagtgct tttacgtagc cttcatcagt aaattcaccc gttttggcgt 3043681 tatagtcctt ttcccgtgtt ttttcatcga ccatccgctg attaagcgtg ccgatatagt 3043741 gcgagattgt ccaagtcgcc tttgttccaa agctgatcgg tgtgtagcca tgttctttca 3043801 gcttttttga cacatcgatt aattcatccc acgtcttcgg gggatcaaga ttcagctttt 3043861 ggaaaatgtc tttattatag aagaatgatt tagcgtccat ttgccacggt acgccatatt 3043921 gcttgttttc ataagtaaat ggtgtaattt gcgattgaac gagctgtgat gaccaatcgg 3043981 tgtcattttt gtagtaggac gagagatcaa gtgctttatt gcctctgata aatttaaaag 3044041 caaactcatc gctccaagag aagtaaatgt caggagggct ggtggttccc agcatgacct 3044101 taattttatc tttataggag tcatttaaaa cggcttcaat ttgaatgtcg atatctgggt 3044161 gatctttttc aaattcctta acaacctctt caaaataact tttttccggc tcctttggcc 3044221 atctgtggaa aaatttcaat gtcacctttc cgtccgctga actgctttgg ctcgaacagc 3044281 ctgcgatggt gagcatactg acagctgcaa tgatcaagaa caacaacatt ttcttcaaag 3044341 ggttggcctc ctctggacat tagactataa tgttatataa cattatagtc taatgcataa 3044401 tggttcttca ttttcagatc aatactcaac tttccacatg tatcttctat gagataaagg 3044461 atgatttctc tcctctgcca gctcgtctgc atagcttctc agcacacgat tgagaacgag 3044521 cggagcaaga tagcctttaa ctgaatcgtc aattgcagtg aagtcgtaag atgcagcatc 3044581 aagcacagtg agctttttgc catacttttt cgagaaggta agcgcccgct cttcaagagg 3044641 tcttgtttca tctaaaccga gcaggatgat aaacggcacg gattcatcaa taatttcaaa 3044701 cggtccgtga aaatattctc cggcatgaat ggcgtgggaa tgaatccatt gcatttccat 3044761 gagaatgcag atgctgtagg agtaagcgac accgtagttt gcaccgcttg ccatggtata 3044821 aataatgctt tctttttcat gggcttttgc aaattgcttg gcgttgtcag cttcctgctt 3044881 aagggctttt tcatatacag cctgcaattg atctaagcct tcaattgctt gctcaaattt 3044941 cgtattgttt tctaatactt gcagggttcc aaaaacgatt tgatacaaaa cgccatagtt 3045001 tgtattgatc gcaagcgcct catcacccca atcgtactgg gcaacatatt gcgcttcctg 3045061 cgctaaagga gactccggtt taaacgtcat cgcaatcgta agtgcgccct tgccccttgc 3045121 aaacgcagca gctttgactg tctccggggt atttcccgaa tgcgagcaca aaataacaag 3045181 agacttttca ccaagctgaa cagggttgcg ctgaataaat tcgttggcgc tgtagagatc 3045241 ggagtttatt gattttgact ctctgtcaaa cacatactta ctcggataca taatggcaga 3045301 agaccctccg catgcgacaa agaatacatg atcaatggtt ttccctttca aatcctgcaa 3045361 gaaagcttga acctcacgat ttacttttgc tgtggcctga ctcaaatcct tcactcctcg 3045421 tttttattat ataacgttat ataacattat atattgttat attaaagtcc gcgggtagga 3045481 ttgtcaatat tattttctga aatttctcaa taatttattc ggatgacaga caaagggtct 3045541 atatgcgaaa aaatgcccaa atcaaaagcc agaacttgac ttaagctctg gcttcgctgt 3045601 tcaatccgca gactgacgtc ttatttaaaa aataccttgt ctatattgta cttcgagtgc 3045661 tgtgtattga tgatatatgt ttcgtaaatc tctctttcca ttggatcatc aactacacat 3045721 acctcaattt tataaacttc atctctgtga tgtttgatcg gtgaaacagt gtcttcgaaa 3045781 tgcttcttaa ttctctgtct taactttctg gctttaccga caaacagcag ctcgtcatga 3045841 atgttgtaaa acataaaaat gccgcctttg tcccttggga tctggtgaaa gtcgatgaat 3045901 ccgtgaatcg gttttatctt cggctcgtta tcattagctg actgctgtcg ttcagtgatg 3045961 gtgacattcg gtgcgggtat atcaattttt atcaaaatca gttcacgtcc tctttttcat 3046021 taaagataaa tgctaacaca tacagaaaag aaaagctaga acagctttat tatatttgtt 3046081 tgtcatgctc ttacttatta tgcaagtgct ccggctggat cataaggact aaggtctaat 3046141 tctgtctgct ttccgagaac tagctttgcg agctctgcac ccaaaaacgg ccccatcgtc 3046201 agtccagaag cacccaaacc gtttgcagcg tacaggcctt gaacattcgg cacggcccct 3046261 acgaccggca gaaatcccgg tgtaaacggc ctgaagccca ctcttgtttc aacagcagcc 3046321 gcatcagcaa gacccggtgc aacggctaac gctttgctca atacttcgtg ctggcctccg 3046381 gctgtcacac gaagatcatc aagaccggca tcgttttcgt gtgtggcgcc ggctacaatt 3046441 ctgccgttat caaacgacag aatgtactga tcactcggcg gcattacaac cggccacgat 3046501 cctgtatctg catctgtcat ttcaaaatgc ataatctgcg ctttttgaaa tgacacttga 3046561 aaatgaatgc caagaggctt caatatctca ttggcccatg ctcccgccgt cacaatgacc 3046621 gcgtcagccg caaactgctt tgtatctgtt tgcacgccgg tgactgttcc gttttcaaaa 3046681 agcaaggacg catttccttt gatgaccgtt gcgccgcgtt tctctgcagc gcttaaaagc 3046741 gaccggcaca gcgctcttcc gttcacacgg gcggcaccgc tgatatgaac cgattcatag 3046801 ccgtcagcta aaatcggaaa cagctttttc gtttcacttg cagacaagcg ggtaatgtcg 3046861 ccgatttccg gcgcatcctc ccgtctctta tacgcccttt cctccatttt atcgagttta 3046921 gacgcgtcag tatgaatgct gatggcaccg acacgtttgt atcctgtatc cgattcaccg 3046981 tctttttcca attgatggat taaatcctta tagtaccgcg ctcccccctt agcaagctgg 3047041 taccaatcct gattacggcg ctgcgagagc caaggacaga cgatccccgc cgccgcatca 3047101 gtcgcttgtc ccggctcttt ccgatcaatg acagtaacgc gagcgcctgt ttttgcgaga 3047161 tgataagccg tcgacgcgcc cagaatccct gcgccgacga tgatgtacga tttcatatgc 3047221 aaacaccttt tctattataa tgtctattca ttttaccaaa tcaaatgctt tccttcgacc 3047281 ttttgcccta atgtggaaaa accgcgaagt tcgtccaatc tctttactct cctatcgaat 3047341 atcctgtcac tatcaataga gaaaggatga taccatgagc gaaaatcgtc atgaaaatga 3047401 agaaaacaga cgcgatgcgg cagtggcaaa agtccaaaac agcggtaatg caaaagtcgt 3047461 ggtcagcgtg aacacagatc aggatcaggc acaggcgcag tcacaagacg gagaagacta 3047521 atgaacgaaa acatcattcc tcttaacaga catactcaag agatacccac tactgaatct 3047581 gttatcaaaa acagcggcaa ctcagaggtc catatcgaca ttcacattga tacaatgcca 3047641 attgcttttg ctatattatg ctctgcatta gccgcaaagc agatgacaaa agaggaattc 3047701 gatatggctt atactcaatt gcgagagatg aacagagaaa ataacagcag atcatctgta 3047761 aagcaaatta tcaatcaaga gacagaagaa gagtaaaaaa ccgcggcccc tcggccagcg 3047821 gtttttcttc tgcatacaaa aaggacgcga ctgaatcggt tacttctgta caatttgaat 3047881 aaggttaccg catgtatcgt cgaagacagc tattgtgact tcgcccattt ttgtcggttc 3047941 cgtcgtaaac gtcacgcctt tttcctttaa tcggttgtac tctttttgaa tatctgcaac 3048001 gccaaacatt gtggccggga ggccttcgga gaatatcttc ttttgatact ccttggcggc 3048061 aggatgttca ttcggttcga gtaaaagctc ggttccgtct tgatcatctg gagaaacaag 3048121 cgttatccac ctgaatttcc ccatgggaac gtcttccttt tttataaacc caagtttttc 3048181 tgtataaaac tccagtgcca tgtcttgatc ttgtacaaat atactggtaa caacgatttt 3048241 catactgttt ttccctcctt cgatatgaat gaagcatggt actatgctaa caatctggct 3048301 acaagcaaaa caacccacac atttatcaga ggccctgttc tgattttata aaattattct 3048361 atccatcctt tcagcaaatt tttaagcggt tcgttgttga atataagtac tcgatatttt 3048421 ccctttcgtt ttgatgttac gagtcctgca tcctccagta cagaaaggtg tttagctatc 3048481 gcctgtcgcg taatagaaag gtcgtacttt gtaataagac gtatcgtaag ttcatacaac 3048541 gtcagctcgt tgcgttcaga taattcgtct aatataagcc gccgagtcga atcgccgagt 3048601 gctttgaata tagcgtcttt gttcccattc atatattgag tataagcaac ccattagttg 3048661 catgtcaagt ataagcaact gtatggttgc gtgatataga aactgaacct atccggcgca 3048721 ggtctgaaat attctaatcg ataaggaatt aaaaccatta aaataacagt ggatatgtct 3048781 ctgaaaaata aaagaagacg aacttcaaaa gttcgtcttc tacaatcaaa ttcggcacgc 3048841 cggccatttt aaagttgata actatctcta aaccccttga taaacaaagg agttttcatc 3048901 attaaccgat agaaccttcc atttcgaact taatcaaacg gttcatttca actgcgtatt 3048961 ccatcggaag ctcttttgtg aatggctcga taaagcccat tacgatcatt tcagttgctt 3049021 cttcttcaga aataccgcgg ctcatcaagt agaagagctg ctcttcagat actttagaca 3049081 ctttcgcttc gtgctccaat gaaatgttat catttaagat ttcattgtaa ggaattgtgt 3049141 cagaagttga tttgttatcc ataatgagcg tatcacactc gatgttagag cgggcgcctt 3049201 ccgctttgcg tccgaagtgg acgattccgc ggtacgttac ttttccgccc tgttttgaaa 3049261 tcgattttga tacgattgta gatgatgtgt ttggtgcaag gtgaatcatt ttcgcacctg 3049321 catcctgatg ctggccttta cccgcaagag cgatagaaag cgtcataccg cgcgcgcctt 3049381 cgccttttag gatacaagcc ggatatttca ttgtcagctt agaaccgatg ttgccgtcga 3049441 tccattccat tgttgcgttt tcttcacaga ctgtacgctt tgttacaagg ttgtaaacgt 3049501 tgttcgccca gttttggatc gttgtataac ggcagtagcc gccttttttc acgatgatct 3049561 caacgaccgc actgtgaagt gagtttgttg tgtaaacagg cgcagtacag ccttcaacat 3049621 aatgaacgct tgcttcttcg tcaacaatga tcagtgtacg ttcgaactga cccatgttct 3049681 cagagttgat acggaagtaa gcttgtagcg gtgtttcaac cttcacgcct ttaggcacgt 3049741 agatgaaaga accgccggac caaacagctg agttaagcgc cgcaaacttg ttatcagtcg 3049801 gcgggattac ttttgcccag tgctcacgga aaatatcttc attctctttc agcgcgctgt 3049861 cagtgtcttt aaagacgatg ccttgtgctt caagatcttc tttcatgttg tggtatacaa 3049921 cctcagattc gtactgagca gaaacacccg caaggtattt ttgttcagct tcaggaatac 3049981 cgagcttgtc gaatgtttgt ttaatttctt caggaacttc atcccaagaa cgctctgaac 3050041 gctcagacgg ttttacgtag tacgtaattt cgtcaaagtt cagtgagttt aaatctccgc 3050101 cccattgagg catcggcata ttgtagaaat gctcaagtga tttcaagcgg aagtcaagca 3050161 tccattgagg ctcttctttc atgcgagaaa tttcttctac gatttctttt gtcaatccgc 3050221 gctctgaacg gaaaatggaa acgtccttgt cgtgaaaacc atacttgtat tcaccaatat 3050281 caggcatttt tttagccatc cattttcact ccaatccttt taattgccgc cttcttcttt 3050341 cgcgactcct ttttcaagtg ctttccatga cagggttgca catttgatac gggcagggaa 3050401 ttttgaaacg ccttgaaggg cttcaatatc cccgagatct atagaatcat catactcttt 3050461 cccttgcatc atatccgaga aaatcttaga catggaaagg gcagtttcaa tatctttccc 3050521 tttaatcgcc tgagtcatca tcgaagcgga tgccattgaa atggaacagc cttccccttc 3050581 aaacttcgca tcttccacga tgtctccgtc aagcttcatt gtcagtctga tgcggtcgcc 3050641 gcatgtcgga ttgttcatat ccacgacaat gctgtcattt aaaacccctt tatttcgcgg 3050701 gtttttgtaa tgatccataa tcacctgtct gtacaatgta tctaagtttg cattaaaaga 3050761 catttgtaaa atactccttt gtcttttgaa gagcttccac aagcttatca atctcttcct 3050821 ctgtattata cagataaaag cttgctcttg cagtagcagt tacatccagc catttcatca 3050881 gcggctgcgc acaatggtgg ccggctctga ctgcgattcc ctccgcatca agcacagtcg 3050941 ccacatcgtg cggatgaaca tcatcaaggt taaatgtgac aagcccggca cgctcttccg 3051001 gcccgtaaac cgttacgccg tcaagctggc ggaagcgttc aagcgcataa gctgcaagct 3051061 tgtgctcatg gcgggaaatc tcatcaagac cgatttcttc gagaaaatca atggcggcac 3051121 cgaggccgat tgctcctgca ataatcggcg tacccgcttc gaatttccac ggaagctctt 3051181 tccaagttga ttcataaagc ccgacaaagt cgatcatttc accgccgaat tcggcaggct 3051241 ccatgttttc cagcagggct ttctttccgt acagcacacc aacaccggta ggtccgcaca 3051301 ttttatggga agaaagcgca aagaagtcgc aatcgagatc ctgcacgtca attttcatgt 3051361 gaggcgtgct ttgtgcaccg tccaccacaa tgacagcccc attgtcatga gcgattttcg 3051421 ccatttcttt aatcgggttg accgtgccga gaacattaga tacatgagac accgcaacaa 3051481 tttttgtgtt gcttgtgacc gtttctctga cgtcttctaa agaaatcgtt ccgtcttcct 3051541 gcaacggaat atattttaat gtggcgccag ttgcttttac agcctgctgc cacggaatga 3051601 tattcgcatg atgctccatg taggtgatga ccacttcatc accaggtttc aggttggcgc 3051661 gcgcatagct taacgccacc atattcagtg atgtggtcgt gccttttgtg aaaataatct 3051721 cagccattga cttcgcgtta ataaacttgc ggactttttc acgcgctcct tcataaccat 3051781 ctgtcgctct ggttccaagt gtatggacgc cccggtgaac attggaattg tattggttat 3051841 aatacttatc cagtgtttca atgacagcac gcggcttctg ggaagtcgcc gcgctgtcga 3051901 gataaacgag atcatgtccg ttcacttgct gatgaaggat cgggaactgt tcacgaatat 3051961 ctgtgatatt cattacttca ctttcctttc gataacagaa actaattgtt tcttaacgcc 3052021 ttcaatcgga agttcattta ctaccggtgc aaggaatccg taaatgacta agcgttctgc 3052081 ttcttctttc ggaattccgc ggctcatcag gtagtaaagc tgaatagggt ccacacggcc 3052141 gacagatgcc gcatgtcctg cagttacatc gtcttcgtca attaaaagaa tagggtttgc 3052201 gtctccgcgt gctttttcgc taagcatcag cacgcgtgat tcttgctccg cattcgcttt 3052261 agaagcgcca tgttcgattt tgccgattcc gttaaagata gaagaagcgg aatccttcat 3052321 cacaccgtgc ttcaagatat agccttcaga agctttaccg aaatggatga tttgtgttgt 3052381 gaagttttct gtttgctctc ctcttccgac aacaaccgtt ttcgtatcgc cgtatgtgcc 3052441 gtcaccgtaa aggtttgttg tgttttcgga aatcgtgtcg ccatcgttca tcaggccgag 3052501 agcccactcg attttgctgt cgcgtccgcg cgcagcaccg cggcggttca cataagttgt 3052561 cacaccgctt gacagattat ccaccgcacc gtatgtcacg ctggcattat cacctgtgat 3052621 gacctcactg ataatattga agacagcgtc tttcgggttt acagtgctga tgtagttttc 3052681 tacatatgtt acagagctgt ggtcttcagc cacaatcagc acgtggttga atagagctgt 3052741 atcattgctt tcgtggacat aaacagcctg aaccggcgtc tccacctgaa catttttcgg 3052801 aacataaagg aatgctcctc cgttaacaag agccgcgtga agtgcagtta acttatgttc 3052861 gtcaaccttc acgccgtcct tcataaagta tttctccacc aagtcgctgt gctcgcgtgc 3052921 agcagtcaga atatcagtga agatgacgcc tttgtctttc aattcttgag aaagagaaag 3052981 atgtgccggc gtctggtcac gctgtacgta taatgtttta tcttcgtttt caatgtcgat 3053041 cagcgctttt acttcatcag tcaaatcttc taatgaagaa agcggttcgt tatccactgt 3053101 atgcttcgcg aaattcgtga agttccagtt tgtgattttt gttttgtcag gtttcggcat 3053161 cggcagatcc tcagcttgtt caagagcctg taagcgcagg ttcttcagcc aggcaggttc 3053221 ttggtgcttt tcggaaaagc ttttgagata ctcctgatct acggatagtt ttgtacctag 3053281 tgtcatatta atccccctaa cgcttacgct tcttggccaa cagtttcgtc ttcaatgcca 3053341 agttcttgtt tgatccagtc ataaccttct gcttcaagac gctgtgcaag ctctgcaccg 3053401 ccggatttta caacgcggcc ttgcatcata acgtgaacaa catccggagt gatgtagttt 3053461 aacaggcgct gatagtgagt gatcatcagg cagccgaagt tttcgctgcg cattttgttg 3053521 atcccttttg atacaacttt caaagcgtca atatcaaggc ctgagtcaat ttcatcaagg 3053581 atggcgattt tcggttcaat catcattaat tgaaggattt cgttgcgttt tttctccccg 3053641 cctgagaagc cttcgttaag atagcgctga gccatttcag ggtccatttc aaggaactcc 3053701 atgttttcgt ccattttgcg gatgaatttc atgagagaaa tttcatcgcc ttcttctctg 3053761 cgcgcgttga ttgctgagcg aaggaagtcg gcatttgtca caccgctgat ttcacttggg 3053821 tactgcattg caaggaataa gcctgcctgc gcacgctcgt ccacttccat ctccagtaca 3053881 tctttgccgt caagcgtgat gctgcctttt gttacttcat atttaggatg ccccataata 3053941 gcagctgata aagtggattt accagttccg ttcgggccca ttactgcgtg gaattctcca 3054001 ccttttattt caaggtttac accctttaag atctctttcc cttcgatttc aacgtgaaga 3054061 tctttgatcg ttaatgttga agcagccata tctatacctc caaaaatata taatcattat 3054121 tctcatttta ttctcattct aattttataa caaatgaaaa gtaaatacaa ctttttatcg 3054181 tgccttgcac attcctcaag tttaacaaag atcagcactt tattaaagcg attgaaaaag 3054241 aaaaagagtg gattcccacc cttttttaaa agattgattt tctcaataag ctcccgcaga 3054301 aatccgcttg cttttttcat aatcaagctc tctctgccgc tctactttca ttcttgtttc 3054361 cagccggcgt ccatattcct cgtatccaat tccgtgtgac agctgcatcg ctttttccat 3054421 ttctgacgta taatcgaggt tcagtctgtc ctggctgctg caaataatga atcaatccct 3054481 tcatatattt gctttttatt gtaccagtgc tgcgttggat gccgcaaaaa cgatttggcg 3054541 tgaaatagcg gcagatgaga cgaaagcatc ctttcagaac aaatgagaat ggtttttcgg 3054601 aatattcctt ctcttaatgc gtggtgtttc cgaattcctc aatgcactgt tgaacgactg 3054661 tcacgccttg gctgaaagct gcgccgcctc caaatgccgc tgccacactg acggcttcga 3054721 gaatgttttc ttctgacgct ccctgatcaa gacagccttt tgtatgatag atcatgcaat 3054781 attcgtcctg agcattgatg gcaattccga gggcgatcag ctgtttttct ctttcagtca 3054841 gagaattccc ggcaaagcac tgttcagtaa attcgttaaa ttttcttccc atcagcggca 3054901 tcttttgttc aaatgtgcct aaaccatgtt tatattgttt taacgcgtcc tgcatgcttc 3054961 ctctgtcttg attcaaagaa aatccctcca tctgtttaac attccttttt attatgaaca 3055021 gcttttagga aaatacgcga aaaaaacccc ggaattctca tccggggttt cagtcttatt 3055081 cagatacagg aagcacagct ccgtcgtatt ttttctcgat gaagtctttg atctttttag 3055141 agtgaagaac ttccatcagc gctttgattt ttgcagaatc ttcttcgcct tttcttactg 3055201 cgatgatgtt agcgtatggg ttgtttttcg ttgattctac ttcaattgcg tcttttttag 3055261 gatttaattt attttggatc gcatagttta cattgatgaa gaccgcgtct ccttctttgt 3055321 tttcatatgc ttttgccgtt aattcaggcg ctactttttt gaattcaagg tttttcgggt 3055381 ttttcttaat gtctttcaat gttgcgtcaa ctgtttccac tttagaatca agagtgatta 3055441 atccagcgtt ttcaagcatt gcaagcatac ggccttgttc agcaacgttg tttgtcagaa 3055501 tgattgtcgc accgtctgga aggtctttca gtgatttgta tgttttagag taaataccga 3055561 atggctctaa gtgaacagcg ccggcattca caagtttgta atctgtgttt tctttcattt 3055621 cttgctcaag gtaaggaatg tgctggaagt agttcgcgtc cacttcttta tcagctaaag 3055681 ctttattgta cattttgtaa tcactaagca ctttcacttt cagcgtatag cctttttctt 3055741 tcagcaatgg ttcagcttct tttaaaattt ccgcatgcgg tgtttttgtt gccgcaacga 3055801 caatttcttt cttgccggat tcagcgccgt tattcgaacc gcaggcagcc ataactcctg 3055861 caaatacaag cagtaatgca cccaaaaata gctttttcaa tgtaaatcct cccttatcgt 3055921 ttgtctataa tatttgttat tagatcaccg atgatttgaa taataaacac gatgattaaa 3055981 ataaacacag tagcaacgaa ggtaacatca gcgttattag actgatatcc ttctacgtac 3056041 gcaaggtttc caaggcctcc tgaaccaatg gctccggcaa ttgccgttga accgattaaa 3056101 gcgatggctg taaccgtaat gccagaaata agagcaggca ttgattccgg aatcagcact 3056161 ttgaaaataa tcgtagacgt tttcgcgccc attgatttag ctgcttcaat cacaccttta 3056221 tccacctcac gcagcgcgat ttcaacaagg cgcgcgtaaa atggtgccga gccgattacc 3056281 agcgccggca atgcggcgtt tggccctaag atcgtgccga ctaaaaattt cgtaaaacct 3056341 aatagtaaaa taattaaaat aaggaacgga atcgatctga atatgttaac aacggctgca 3056401 atcactgagt tgaccgcttt attctgccag aggcttcctt tgctcgtcag aaagagcagc 3056461 aagccgagga tgaccccgat gacaaaagca aacagtaaag aaatcagcgt catataaagt 3056521 gtttcatatg tcgcgttcca taattcagtt aaatcaacgt tcgggaagta tttttcaaac 3056581 attcgtgatc acctctgctt tcacctgttt gtcattaatg aatcggatca cgttttgcac 3056641 ttcttcctcg tccccgtcaa tgtggatgaa cagtgaaccg taagccccat ccttcgtctg 3056701 cgaaattttc ccttgcagaa tattgacgct gacattgaag tttctgatca tctctgtaat 3056761 cagaggctgt tcagctgact caccgacaaa tgtgagctga accatttttc ctgatgctgt 3056821 atcatcaaga aggtgctgaa gcgtctcttt cgtttcttcc ggctctgtca cctgttgaac 3056881 aaatcgtttt gtcatttgtt cctttggatt tttgaagaca tcgagaacct cgccttcttc 3056941 gaccaccttg ccgttttcca tgacggcgac tctgttgcag attttgcgta tgacatgcat 3057001 ttcgtgcgta atcagcacaa tcgtcaaacc gagtctttca ttaatatcgg acaatagatc 3057061 cagaattgaa tctgtcgttt gcggatctaa tgctgatgtc gcttcgtcac aaagaagaac 3057121 cttcggattg tttgcaagcg ctctggcaat tccgacacgc tgcttctgac cgccgctcag 3057181 ctgggacgga taagattttt cttttccttc taaacctacc agtttaatca gttcattggc 3057241 gcgcttgatc cgctcgctct ttttcacccc ggcaatttct aaaggaaaca tgatattatc 3057301 tctgacagtc cgcgaccaaa gcaaattgaa atgctggaaa atcatactga tctcatggcg 3057361 tgcttttctt aaaccgcgtc catttacttc attaatcttg gttcccgcca cttccacggt 3057421 tcctgaggtt ggtttctcaa ggccgttcag cagacggatt aaggaactct taccagctcc 3057481 gctatatcct ataattccaa aaatctcacc ttttttaatg gaaagcgaga cgttttggac 3057541 agcattgaca tctccatgtt tcgacttgta aacttttgaa acatcctgaa gattgatcaa 3057601 agcaatcacc tgccttaaca ctattctaag aaatcttccg gttttttctg caaaagaaaa 3057661 gcctttctgc acacttgagc agaaaggctt atataaaatg cctttctctc atctttcaaa 3057721 gctgaacgct tcgtgtgaat tggcaccatt tcaacagtgt tgatggttgc cgggcttcat 3057781 agggcacttc cctccacctc tcttgataag agaaatatat agtctttttc gtccggaaat 3057841 tcttaatgta gaatagcacg gcgaatgatt aaatgtcaat aaaataaatg atgtcaactt 3057901 ttactattat aataatttat tattttttaa ttttttaaaa tcctctgaaa aaatccattt 3057961 gtcagccaga gaatggcttc cagctttaac agggccctga atgacccctt tactttgagg 3058021 cttccgctct gaataaggtg ctgaagggaa atgtctccgt gcaataaatc aataatttcc 3058081 gtttggtttc cgtaaaaggt caggttggac gtttggggcg gagaaacttt tttcatttct 3058141 ccctgttcgt ttattgagac ggttaaggct tctgcttctc cttggaaggt aatgagcaat 3058201 gttgaggcat tcaaaagggg ttttaaaaac agatgctgat actcatcttc taaaacttcc 3058261 gctttctcca tatgtacaac ctcctatttg ttggtcatac atacacattt ctctctttgt 3058321 cgcaagaacc cctttataaa acgaacgaca atttcattgg atatgctgag aaatatgtca 3058381 taaatgggat gcggaagatg atttttgttt gatcagctca tataaataag aaacggaatg 3058441 aaatgcatat cctctttcga ccatctttcc gcctttaaac agcagaaaac aagggacgct 3058501 ttcaatttga tacgcttttg cgaatgtcgg agagtaattg acattgtttt gatagaaggc 3058561 gacatccggc agcatttctt tcaccactgt cagcattttg cttgcaagct ggcaggtgcc 3058621 gcaaaacgga gtatataaat atagaaggta cacatcatct tcaatgtgat caagttcgtg 3058681 ttcttggagt tctttcatgc tatacacctc gggactttct ttcaagaaaa atagtatgga 3058741 cattcagatt cgcacgcagc aatacagaag cgatatggtg cctgggcgca gccgctactt 3058801 ccttataggc tctgtcgaca tggagatggc aggcttcatt aaattcacgc ttcagctgtt 3058861 ttctcaattt ctcacctgat tcatcagcat caactaatat atagacgtct ttatcataaa 3058921 gctcgtcagc caattcctcg agcctcagct ggctgattgt tccgtttgtg cagataatgc 3058981 gcatcggttc attcaggacg ctttcgattt tctctttatc tgatttcccc tcgacaatca 3059041 taaccttttc cagctcatcc atcttcatct tgttcacctg ccgcgtcaaa tttgaaatgt 3059101 tcagattgta aaagaaggca gtgaaattca ccgccaacat taacaccagc cgttttcgta 3059161 gtcacaatct acatattttg cgtcgtctcc agagaccaca tcggctgtct tataaaattt 3059221 ctcattttca aaggaataac cggacttaag ctcatattca ttcatgcttg tcatttggcc 3059281 gatcatctca ttatcatgat ataacgagag ccggccattt tgaaagcggc ctgtcacgtc 3059341 attggtgaca tcgagctttt gtttgtcgaa agccatattg gacacctccc ataacgttag 3059401 cgtgtccaat tgcttttacg gctatcctgt tttagtcttc ttgtgtcatc tcttcgtatt 3059461 gctctgctgt catcagtttt tcaatttcag aagcgtcaga tggctcaacg acgatcatcc 3059521 atgctttttc gtacggagat tcgttgacga attccggact gtcatcaaga tcttcgttta 3059581 cttccacaac cgttccgtta atcggtgcat aaagctcaga taccgtttta acggattcaa 3059641 cactgccgaa tggctcgtcc gctttgattt cagcgcccac ttcaggaagt tcgacaaaca 3059701 cgatgtcgcc tagttcggac tgggcaaaat gcgtaattcc gattctggct ttttctcctt 3059761 caacttttac ccactcgtgt tctcctgagt aacgcaaatc ttttggtatg ctcaattgaa 3059821 tccctccatt ttttacagca ctacaataag aagataccac acttttcaaa aaaaatttac 3059881 attaagccca gttttcttca aattggtctt ctttaaatcc gacagtcact ttttcgccgt 3059941 ctgttgtaag cgggcgttta attagcatac catctgaagc cagcagttcg agctgttcgt 3060001 cctctgacat atgatacagc ttttccttga gattgagctc gcggtatttc atgccgctcg 3060061 tgttgaaaaa tttcttgaga tccagcccgc ttttttcata aagcgctttt aattcttctt 3060121 tgcttggcgg ctgctcagca atatgtattt cgtttatttc tttcccatgc tcttcaagcc 3060181 acttctttgc tttgcggcac gttccgcatt tagggtacca gtaaaaagtt aacgacatct 3060241 tcttccccct caataaaata atcgaggtta ttttaacaca gtttgtttta aaaacctaaa 3060301 acagtgcttc ttaaaaaaga gctccgcgca tgcggagctc atggccaatc agacagtata 3060361 tttctcagcc tcaaaaatgc ctgccgccgc ctcgcgtttt ttctgaatca cgtttttagg 3060421 cgttacgcgt gtcagcttgc gcagagcgga aagcatcatg cggagtgaat ctccttcttc 3060481 cattgcgata agggattcct ttgcatgcgc ttcgatttcg ttaaaggcct cttgaacgaa 3060541 aatttctgtg tacagcacct tttgcgctgc tttttcagcg ccttgtgcgg caatggcctt 3060601 ttccgttctg agcacggctg attccattgc gtatacattg ctgacgatat ccgctacgtt 3060661 cacgagaatt tcttgctcac gatcgatcgc ttttccgtat ttttgcgcgg ctaggccggc 3060721 agcaaacaac gcaatttttt tggcttgctt gacgatatat ttctcctgct ctaagacgcc 3060781 gcttccaggc tcttcaggca taagcatcat gagttcttcc tgcagcgact gcgctttttc 3060841 gaataaaggc agctcgcctt taagcgcttt tttcaggaag gtgcttggca cgattaaccg 3060901 gttgatttcg tttgtgcctt caaaaatccg attgatcctt gaatccctat aggccctttc 3060961 tacttcgtat tcctgcataa agccgtagcc tccatgaatc tgcacgcctt catcaacgat 3061021 ataatcaagc gtttcagagc cgaatacctt attcagagag cattcgatgg cgtattccgc 3061081 aatcgatttg gcgatttgcc ggccgtcctt gagatcttcg gccgtgaact ggctcatatt 3061141 gtcttcaaac agcccgacgg ttctgtatac agagctttcc atcgcataca gccttgaggc 3061201 cattgtcccg attttttcct gtgtcaatga aaaaccagca atcggcgttt taaattggcg 3061261 gcgctgattt gcgtatgccg cagacagctc gatgacgcgt ttagatgcgc cgattgtgcc 3061321 aaccgccagt ttgtaacggc cgatgtttaa aatattaaag gcgatgacat gccctttgcc 3061381 gatttctccg agcaggtttt cctttggcac ttcagcttga tccagaatga gggttcttgt 3061441 cgatgatccc ttgattccca ttttcttttc ttccggtccc gtggagacac ccgggaactc 3061501 tttttctaca ataaaggctg aaaacttgtc gccgtctacc ttagcgtaaa ctacaaatac 3061561 atcggcaaaa gcagagttgg taatccactg tttttcccct gttaatacat aatgggttcc 3061621 tgcttcattc agcacagctg ttgtttttgc tccaagtgca tcagacccag agccaggctc 3061681 agtcagagca taagcggcga tcttttcgcc tgaagcgagt ccaggcaaat attttttctt 3061741 ttgttcttct gacccgaaaa agacgatcgg caaggaaccg ataccgacat gcgcgccata 3061801 agaaagagaa aagcttcccg cacgcgaaaa tttctcagtg atgagtgccg agctgatttt 3061861 atcaaggccg agcccgccgt attcttccgg cacatcggcg ccaagcagcc ctagttcgcc 3061921 cgctttcttc aacagtctga cagaatgctc gaattgatgg ttttcgatat catctatatg 3061981 agggagaaca tcttgctcga tgtaatcctc tgttgttttc gcaatcattt tatgctcgtc 3062041 agtgaaatcc tccggtgtat acatttgatc gtatgtgaca tcctcgatta aaaatccgcc 3062101 gcctttttgt acgtcagccg ctttttttgc catttgtttt tcccccttta gcataattca 3062161 aatacaccgg ccgctcccat tccgccgccg atacacatgg tcacgactcc aaattgctcg 3062221 tttctccgtt tcatttcatg gatgagtgag agtgtaagct ttgtgcccgt acagccaagc 3062281 gggtgtccaa gcgcgattgc gcccccgttg acattcactt tttcttcatc aattcccaat 3062341 tccctgatta cttgaatggc ctgtgaggca aaagcttcat tcagttcaaa caagccgatg 3062401 tcctgcagct gaagtccggc aagcttcaaa gcgcgcggaa tcgcttccac cggtccgatt 3062461 cccatcactt ccggcggcac gccgcctacc gcaaaggagc ggaatttcac aagcggcgcc 3062521 aggccaagag catcggcttt ttcccggtcc atcagcatga cagccgccgc tccgtcactc 3062581 gtttgtgagg aattgcccgc agtcaccgtc ccgtcaacgg aaaaggccgg gcgcaatgtc 3062641 gataagatgt ctgcagtcgt ttgcgggcga acaccttcat cctgagaaaa cacaaactgt 3062701 ttttccatag gcttatggtc ttctccgatt tctgtcaccg tcacttcgac gggtacaatt 3062761 tcatctttaa attttccttc tgcaagggct ttagcggcgt tttgatggct gcgaacggca 3062821 aacgcgtctt gatcctcacg ggagacgccg tattttttcg cgacttgctc ggctgtgtgc 3062881 cccatgctca tataatattc cggtgccttt tctgccaaag caaggttcgg acgggtaaca 3062941 tgccccatca tcggaacttg cgacatggat tctgctccgc cggcgatcgc tgtatcgtag 3063001 gcgcccagca taattttttc tgctgcatac gcaatagact gaaggcctga agagcaatag 3063061 cggttaactg taatcgccgg aaccgtgtac ggcaggcccg cgagcgcacc gatatttctc 3063121 gccatattaa gcccctgctc cgcttcaggt gttgcacagc cgataatcaa gtcatcaata 3063181 ttgccttcgt agccgcctgc ccgtttcagc gtttctttta cacaaatcgc tcccaaatca 3063241 tccgggcgaa cggtggccaa cgatcctttt tttgcttttc caaccggtgt tcttgcacct 3063301 gacacaatga ctgcctcttt cataagctcc ctcctaattc cgtaaaggtt tacctttcac 3063361 aagcatatgc tgcattctcg cttgagattt tgcctctcct gacaaactca aaaacgcttc 3063421 tctttcgatc tccaataaat actcttcatc aacctctgta ccaaacggca cttttccgcc 3063481 cgcaatgaca taagcgagtt ttttcgcgat cttaaaatca tgctcagata tatagccgga 3063541 cagcttcatc tgctcagcgc caagcaagag tgccgcataa ccggtttctc ccggcacctt 3063601 gaccttttct tttacaggcg gccgccagcc ggtatcgtat aaagatgcgg ccagctgctt 3063661 cgcatcgtat aacaggtggt cttgattcac gctgatctga tccgtttctt ttaagatgtt 3063721 catctcacga gcctcttgag cggaagcgga cactttcgcc atcgcgattg tttcaaatgt 3063781 tttcattgcc gcattcatcg gatcatggcc gcggcgaaga tggttgatgt acagctcttt 3063841 gttacctcct ccgccaggga tgaggccgac accggattcc acaagtccca tataggcttc 3063901 gcttgccgct tgaatgcgcg ccgccggcag gcatgcttcc gttcctccgc cgagcgtcat 3063961 gccaaatggc gcggcgacga ccggtttcgc actgtatttg atcttcatca tcgtctcctg 3064021 aaaacggcgg atcacaaaat caacttccaa aaagttgtca tcttggactt ccattaagat 3064081 catggcgaga ttcgcgccga cgcagaaatt tttcccttga ttgccgatga caagcccctt 3064141 gtaattccgt tctgtttcct ctaatccttt gtggatcatt tgaatgatat cgaggccgat 3064201 cgcattgctt ttcgaatgaa attcaagaag ggccacatca tctccaaggt caattaagct 3064261 tgctccgctg tttttcgcaa tcacgccttt tgtttcttta agtgcttgta aatgaattcg 3064321 ttttttgttt tctttcacgg ctctgtattc gccgcggtca taataaaata ccgttccgtt 3064381 ctctttgatg tagaaggttt catttccttt gtccagcatc tcttttatcc agccaggcat 3064441 atctgctcca agctgctcaa gcttttccgc tgactgcttg aggccgatgg cgtcccacat 3064501 ctcaaaaggt cccagttccc agccgaatcc ccacttcatg gcttggtcaa tcgcatgaat 3064561 atcatcggca atctcgccaa gcagctcggc tgagtaaagc agggtttgag aagtgatatt 3064621 ccacagcaaa cggccggccc tgtcatccga ataaataagc gctttcattt tggcttttgt 3064681 cccttttgcc tgttttgccg cttcaagtgc cggtgatttc atttttgtcc gctcgccgta 3064741 agtaagcgtc actgggtcaa gctcataaat cgtttttcct tcttttttat aaaagccttg 3064801 gccggccttg cttccgatcc accctttttc cagcatatcg ttcatgaagc ttggaatgcg 3064861 aaacacttct ttttcatcgc catcagcttt gtcatacaca tttcgggcaa cgtgggcgaa 3064921 tgtatcgagg ccgaccacat caagcgttct aaaggtggcg cttttcggcc tgccgatcag 3064981 cggtcctgtg atcgaatcaa cctccccgac ctgataaccg cctttcagca tttcttggac 3065041 tgtcacgaga agcccgtaag tcccgatgcg gtttgcgata aagttcggtg tgtcctttgc 3065101 tgtaacaacg cctttcccga ggacattttc tccgaaagct gtcataaact ttaaaatatc 3065161 aggatccgtt tccttaatcg gaatgatctc tagcagcttt aaatatcgtg cgggattaaa 3065221 aaaatgcgtt ccaagaaaat gggctttaaa atcatccgac cggccttcag ccatttcctg 3065281 cactgatatg ccggatgtgt tgcttgagac gatgcttcca gtctttcgat gttcatccac 3065341 aagagcgaaa attttctttt tgacttcaag gttttcgaca acgacctcaa taatccaatc 3065401 tgcttctttc agtttttctg catcatcctc cagattgcca ggtgtaatat aggaggtatt 3065461 tttcgctgat gtgaggggag cgggcttttg tttcagcagt tttttcatcg cctgccggct 3065521 cagcctgctg cgcacctccg aactgtcctt cgtcagcccc tttttttcct cttcctttgt 3065581 caaatcgttc ggcacaatat ctagcagcag gacaggaatt ccgatgttag ccaaatgcgc 3065641 cgctatcccg gaacccatta cccccgatcc taaaacggct gccttccgaa tgtgtttgtg 3065701 catgagatat cccccttgaa cattgaatga atagtcattc attttttgac taaaaaaaat 3065761 gaaacccgtt tcttctttca tcttaaaaga tttccggttc gacttcaata gctaatttgt 3065821 tatttttttg tatgaagcct ataaaagtcg ggcaacttaa gcccggaggt gaagggaatg 3065881 gtacgagaga aaaaaaatcc gtcttcagcg gcagtcagcg cggcgagcgt aaagggagat 3065941 gccggtccga ctcagcatta cggcggcgga aaacggacaa gtcaaaatca gcagtataaa 3066001 aaacataaca tgggacaatc ataatgcagc tgcttcccac ggctgctttc actttttcaa 3066061 aattcctttt aacacaaacg ctgcattggc aggccgttcg gcaattcttc tcataaagta 3066121 gctgaaccag tccgttccat atgggacata cacacgcatt ctgtagcctt ccttggcgag 3066181 ttccttctga cgctccggcc tgatgccgta tagcatttga aactcaaatt gcgatgcggg 3066241 gatttgatgt tcggcgacga gctgtttcgt aaatgcaatg atgtcatcgt catgtgtggc 3066301 gacagccgtg tagttcccgc ttaacaactg cagctttatt aagctctgaa aatgaaggtc 3066361 cgtgcctctt ttgtcgggaa acgctacagc cgcagattct ttataagcgc cttttacaag 3066421 tctgagattc ggctttaagt cccgcatctt tctgatatct tctgccgccc ggtacaaata 3066481 cgcctgaatg accgtgccga gcttctcaaa ttcctgtttg cattgcctgt aaatagaaag 3066541 tgtctgttca taatgagaat agtcttccat atcaatggtc acagcaacat catattgctt 3066601 cgcaacggaa agaatggcgc gcaaatgagt aagagcaagt tcttctgaaa gatcgagccc 3066661 gattgaggtc agcttaagtg aaagctctga attcaattga tgttcggcaa tggcttgaat 3066721 ggctttcttg cattcctctg cgacttggtt tgcttctttt tccgaagctg catactcgcc 3066781 taaataatca attgttgcac acaaaccgga tctgtttagc cttttgacgg tcttaaccgc 3066841 cgattcaatc gtatcccctg cgacaaacct tcgtgctcca agccgcgttc cgtatgcttt 3066901 tgcgaacttg gtaagtgttt tattttgaga taagaataaa aacacatgtc tcaacatccg 3066961 actccctccc gccgtcatct tcaaaacacc tgtatataac tcccagtctg aaggaaacta 3067021 taaaatgaac agaaaccaaa ggaggatcac aatggataat cagcagcaat ctcaaatgcc 3067081 gccttccgtt atttcgacaa aggatcattt gtatctcaat gacatgctga actggaattt 3067141 gctcgcgatg aaaaaagcgc atttcatggc gcagcagtgc caggatcaaa cgttaaagca 3067201 agaactcgac cgcgtcggac acatgcatca tgatcactat caaagaatat taaagcacct 3067261 gcagccaggc cagcagcagt ccggctacat ccaataagga ggcgccagaa tgaatcagca 3067321 aaatcaaaaa atcagcaacc cgcagacacc tgtaccgaca acatcggaaa tgaatgacag 3067381 agatttcgtc aacgaattgc tgacaaccga aaaatacatg acaacagctt attgcactgc 3067441 cttgcacgaa ttcagccacg agtctcttta tcaggatatt caatccattt ttgatgagtc 3067501 acaaaaagcg caaagaaaac tatatgatct catgttccaa tatggatggt attctgttga 3067561 agcggaggat tcacaaaagc tgcagcagtc ctatcaaaaa ttccagcaga ccattcagca 3067621 gcagtctcct tatcagcaat aacaacatta gtaaaaagga tacgatgttc tttcgggcat 3067681 ctatcctttt tttgtgtaaa atcagttgac ttttcattta cgcttattta tatttaataa 3067741 gcattaacta ttttgtcatt aaaatatata tacagtgtat gtaacagagg ggaaatgaat 3067801 atgaagagtg cggatcagtt aatgtccgat attcaattat cgcttcaggc gctctttcaa 3067861 aagatacagc ctgaaatgct ggaaagcatg gagaaacaag gtgtcacccc agcgcagctg 3067921 tttgtgctgg ccagcctaaa gaaacacggc agcctcaaag tttctgaaat tgccgagcgt 3067981 atggaggtga agccaagcgc ggtgacgctg atggcagatc gccttgaaca aaaaaatctt 3068041 atcgccagaa cacacaacac aaaagacagg cgagtgattg atctcagtct tactgacgaa 3068101 ggagacataa agttcgagga ggttttggcg ggcagaaaag ccataatggc gcgctatctt 3068161 tcctttttga cggaggagga aatgctgcag gcggcgcata ttacagcaaa actcgcacaa 3068221 gcagcagaaa cggatgaaaa gcaaaacatg aaaagaggaa acggatgaaa atgagtaaag 3068281 aaggcaaaca atcaaaacga acgttattaa taacaggctt aattattgcc atgttttttt 3068341 cagcccttga cggtaccatt gtcggaacgg ccatgccgaa aattgtcggt gatctgggcg 3068401 gtttgagcat gatgacctgg ctgacaactg catatttgtt aacatcaaca accattgttc 3068461 caattgccgg taaactggct gatttattgg gacgccgcat tgtctatgta tcaggtttga 3068521 ttatttttat ggccgcttct gctttgtgcg gaatggccaa caacatgacg gaattgatta 3068581 tcttccgtgg actgcagggc atcggcggag gcatcatgat gccgatggcg atgattgtca 3068641 tcggtgactt gttcacagga aaacagcgtg ctaaattcca aggtgtcttt ggcgcaattt 3068701 acgggctggc ttcagtgatt gggccgcaaa tcggcggctg gattgtagac tcgttaaact 3068761 ggaaatgggt tttctatatt aacctgccag tcggaattat tgcggttatt tttattgcca 3068821 ggggattaca gggacgccag cagactggtc cgatcaactt cgatatcgct ggtattttca 3068881 caatgattgt cggtgtggtc agcctcctgc tcgccttaag ctttggcgga aaagattatg 3068941 catgggattc atggcagatt cttgggttgt tcgctctcgc actgatcggc attgtcagct 3069001 ttatcatcgt agaatcaaaa gcaaaagagc caatcctgcc aatgtattta tttaaaaaca 3069061 gaacatttac atttctaaac ttgatcggct tctttatgag tatcggtatg tttggcgcca 3069121 ttacgtttgt tcctttcttt atgcagggaa ttgtcggtgt aagtgcgtct gaatcgggta 3069181 caattatgac accgatgatg atttctatga ttatcacaag tatcatcggc ggacagcttg 3069241 tttataaaat tgggattaaa ccgcaaatca ttacaggcat gctggttatg gccggcggat 3069301 tcctgctgtt aacgacattg gatctcgaca cgagcaagct tgtcgctaca tcttttatgg 3069361 cgattattgg tctgggaatg ggtcttgtta tgccgattct gacattggct ttacaggaaa 3069421 gcttttcgaa ggaggagctt ggagttgtca cttcatccag ccaattcttc cgttctatcg 3069481 gcggaacatt cggcattacc atgctgggag ccgtaatgaa tgcgagatca ggaaatctat 3069541 taacagataa attggttcca tatttagact ctcttccggc acaggcaagc tcgtttgccg 3069601 cccagctaaa gggtatgatt gatacaaatc cgcaagggct gctgcaatca ctgttcagtc 3069661 cggacgcggt caaacaaatc cctgcggctt tctcatccca tattgtgccg attttaaaaa 3069721 catcgttgat ggattcgctc cacagcgtgt tttatacggg cctgatcttt atcgcagtcg 3069781 gagccgtatt caccttgttc ttaaaaccta tcaagctatc aaataagaaa gcggaagacc 3069841 aacaagaaaa agagaaggcg gcaaaagccg ttgaatcacc ttcccattaa tagagcaccc 3069901 cgcgggtatc aatccgcggg gttttttatt caatcatctg ggctcttcca tttccgaaag 3069961 accaatcctc atcctgattt ccggccagca tgataaacac atcttctttt cttacaccaa 3070021 gctcggaatg aatccggctc gcgattgagc ggtaaagtgc ttttttctgt tcagttgttc 3070081 ttgactgttt cagtgtaaaa tgaatgtata tcagttcatc agtacgctcg acttggagat 3070141 aaaatggatc ataaaaaaat tcgctttttt catattgtct gatgacttgg aaatagtcat 3070201 cttccggcac attgatttct tcaatcatcg attggtggat agtcctgctc agtttttgaa 3070261 gccacacttc gcttcttccc gaccgtaaat gaatctgtac aaatggcatc tccccgcatc 3070321 cctttcttta cagcgtctgt ccgctgtcaa ttgtgataat ttggcctgtg agtgattcct 3070381 gttcaattag tgaacaaatc aatttggcaa catcatctgg ttcagcaata cactgcagca 3070441 gcaaagagcc gatcatgctt ttcatttttt cttcccgtcc ggcccaccat ctcgttgcca 3070501 cagctcctgg tgctacaccg ctcactctga tttcaggcgc taaggcgtgg gccaatgatt 3070561 tcgttaaacc gtgcaccgct gattttgata ctgcgtaagg cattgatgag ccggcaccag 3070621 ttatccctgc gatgctgccg acgtttacga tcgccccgtc cttgcttttc ttcatgaacg 3070681 gaaccactgc ccgcgcgcag aaaaacatcc ctttcacatt gacggcatac agctcatcct 3070741 agacgtcttc tgtcgcagcc tcaagatcat ccattggaat atgccgtgta atgctggcat 3070801 tgttgactaa aatatcaacc gtgccgtgtg tgttcacgat tgcttgaatc atatcctgca 3070861 cgtcgctgtt tttggataca tctgcttgga tggcgaaggc ttgcccgcca gctttttgaa 3070921 tcatttccac tgtttcctcc gcttctgatt gcgagcgtga ataattcacc gccacaatcg 3070981 ccccacgctt tgccaattcc atactggctg cttttccgat tcctgtgccg ccccccgtta 3071041 cgagagctat tttgttcaag acattcattg ccgccactcc ttgctgttga ctaaagtata 3071101 tttctgattc cattgtaatc cagctttgat gttacgtata atgattgtta aagatactag 3071161 atatcactca gattgatagt aaacgaacgg aggagttcaa aatggaaagc ggagatttac 3071221 gtgtgtttca aatggtagct cgtgaaggga ccattacgaa agcagccctg cagcttggct 3071281 atgtacaatc gaatgtcacg gccagaattc aacaattgga agctgagctg ggtaccacac 3071341 tgtttttgcg ccataatcgg ggcatgacac tttctgcaag cggaaaattg ctgctggact 3071401 acgcaaataa aattataggc cttcttgatg aagcgtctaa agcgctctca tcctccgcag 3071461 aaccaagcgg gccgcttatg atcggctgca ctcagacaac cgccgcggta aggcttccaa 3071521 agcttctggc atcttattat gaagaacatc caaacgtcca gctgtcttta acaacaggac 3071581 atacgcaatt tctccttgat aaagttcttc gttatgaatt ggatggcgcg tttatcggat 3071641 gcgaatgcca tcatcctgag ctcgaatcct atcctgcgtt tgaggaagaa ccagtagttg 3071701 tttcggctgc ctccgtgccc gatgttgagg aagccatcac aaagccgatt ctcgtttaca 3071761 gcacaggctg ttcgtatcga gaaacacttg aaaaatggct gcgttccgtc ggtgtcacac 3071821 agccggtcat tatggaattt gggacgcttg aagcaattat cggcggggtt acagcaggtc 3071881 ttggcatctc gttgctgcca agaacggttg tgcagaaaca tgaagcagaa ggatcaattc 3071941 gattgtaccc gctgcctgaa gctctcagcc agatgaaaac agagtttatt gttcgaaaag 3072001 attcgtttat cagcagcgcg ctgagaacct ttatggattc ctttacgcca gttaaaacgg 3072061 ctgaatcaca aaaaagcagt ctgctataat gaacagactg ctttttggct attgtttgtt 3072121 tcgatgcgct tcatttaatt ccttaatatg ctgaatgatc tctttaatgc cctgcttcgc 3072181 gtcggggtat gtcgcattcc aatgcttagc gagcggaggc atgcttttgg ctatatgggt 3072241 gtacaaaatc cattgcttca cttcttcttt tagctcatcg tttgtttcac caagcagaag 3072301 ctcagtatac ttctccagca atccatcaag ctgctcctga agtttttgtt ccattttcca 3072361 tcttcctttc gaaaaaacag caaggagctt tctcaattga aagctccttc gctgcgttat 3072421 ttatccatgt gatgtgaaag ccgcttcctg gacaatgcat ctgcccctgc catgaggaat 3072481 gcaaagaggc gttccgaaga gcgggtcctg tgtaacctga cagttcatag aaaacacatt 3072541 ttgcacaaga tcacaagtga tgacctcttc cggacggcct tctgcataaa tccgtttatc 3072601 ttttatggcc acaagatgat gcgcatagcg gcacgccaag tttaagtcat ggagaaccat 3072661 aacaatcgtc cggtcttcct tttcattcag ctcaaacagc aaatcaagaa tttcaatttg 3072721 atgcgtcatg tctaaatacg tcgtcggctc gtcaagaagg atgatatccg tttcctgggc 3072781 aagcgtcatc gcgatccaag cccgctggcg ctgtccgcct gacaaagaat caacggcacg 3072841 gtcagccatg tcctcaagct ttgttgcttt aagcgctctt tcaactgctt cctcatcctc 3072901 ttttgaccac tgcttcagcc agttttggta aggatatctt ccttgcttca ccagctgatg 3072961 caccgtcagc ccctctggag ccgaaggacc ttggggcagg attgcgagct cttttgcgac 3073021 ttccttcgtc ggaagcttgg caatcgctct tccttccagc agcactgaac cgcctctcgg 3073081 cttcatcagg cgcgctaatg aacgtaaaag tgtcgatttt ccgcagccat tgctgccaat 3073141 aaatacggta atttcacctt tgggaattgt taaattcaac tcatcaataa taacggcatc 3073201 cccgtatcct aagctcagcg tttctgtaga aattgcactc atacccataa ccgctccttt 3073261 ttgctggctt tttagcagca ctatgtattg cacgttttct atatacatgc ttttaagtca 3073321 attgtcatca atgcaaatga ttccgatatt cagccatttg atatggtcat atatccctca 3073381 ttgtagcaga aaacactgac tttgaaaatc attttcaatt agttttatgg acataattga 3073441 cgtttatggg ttttttatca caagattact tcttgatttc tctgatggag ccgtccttca 3073501 gcttcaattt taaatcgata tgatcataat gactgtccag attaaatgct gccagcacac 3073561 tgtgtatcac ttctgtttca gccatttggt ctgtcacgga aagctcgctc aaaatcattt 3073621 tcatctcatc taacgcttct tctccttcct gattgacacc ggagagctta tcctgtattt 3073681 ccgctttttc ctgagtcccg ttctttgtat agattccttc ataacggtta tgctcaccat 3073741 ccccgtagct cacacgaagc gaaaaattac tgtagggaac ggacttcagc tgggtgacgg 3073801 ctgtattttc tccttctgcc tgatgctggt cttcattgaa acggcagccc gcaatcagaa 3073861 ccactgcgag acatacagcc ccggctgctc tgatcaaatg catatgtttc ccccctgtag 3073921 gattccattt attttaggta tatccagaga atgaaatcct cattcagaga agaattgaaa 3073981 aagccggggc atttaacgcc acggcttttt ctttaagatt cggtcatttg taaaaaggtt 3074041 tcggcgtcac gcacagccag cttgatggca ttctcccaga aatcgcgctt tgtgatgtca 3074101 gcgcccaaat gcttcatcgc caaatcctcc actgtcatag aagccgtatc gcgcaatagc 3074161 gccatatact tctcttcgaa tgtgtctttt tcttcaagcg ccaacgcgta aataccaaga 3074221 gaaaacaggt agccgaatgt ataagggaaa ttgtaaaacg gcaccctcgt gatgtgaaaa 3074281 tgaagctttg atgcccaaaa aagcggatga tattcttcta acgcattgca gtatgcctct 3074341 ctttgcgcct cttccatcag ctcattcaag cggctggccg gtaccactcc ccgctttcgt 3074401 tcctcgtaga atctcgtttc aaatagaaat cttgcgtgaa tgttcatgaa gaacgcaacg 3074461 cttctttgca ctttatcctc cagaagaaca agcttttctt ccctcgtctc ggcctgctgg 3074521 acagtcgcgt ccgccactat catctctgca aacgttgaag ctgtttctgc aacgttcatg 3074581 gcgtaggaac ggtttaacgg cctgacgttg agcattgctt cctgatggaa cgcgtgcccg 3074641 agttcatgcg caagggtaga gacatttgag gcgcttcccg aaaatgtcat gaaaatccgg 3074701 gattccccgc tgtccggaaa actggtgcaa aagccgccga ctctttttcc gctcctgtct 3074761 tccgcctcaa tccagccgtc ccgaaacgct ttttcagtga atgaggacag ctttttgcca 3074821 aacgttgaaa actggctggt aatgatattt gcggcttcat catacgaata gacctttccg 3074881 tcagaaccga tcggtgcctc gacatcgtac cagctgagtt tttcaaggcc gagcatggat 3074941 gctttccggt tcaaaaactg aacgaacggc ttcttgtttt cagtgatgac ctgccacatc 3075001 gtatcaagtg tttctttttt catcctgtta atttgcagcg gttccttcag gacattctcc 3075061 cagccgcgcg ctttataggt ttcaagccgg aatcccgcca aatgattcag cgtgctgctg 3075121 aaaatatctt gcttgctctc ccaagcttgg cggaaacgtt catatactgt ttttctgaca 3075181 gtacggtctt gatgatccat catattctcc gcctgaccga cagacaattg cttgttttca 3075241 ccgttttcct catacgggat cgtcattttc ccgacaacca tattgtataa gtcactccaa 3075301 gcgtgatatc cgtccaccgc aaggtttccg atcagttttt ccttaccggg gctaagcttt 3075361 tcggcaaccc tctgtcttct ttcatttaat atgtaagaaa catcgcgcaa tcccggtttt 3075421 gttaacaatt cattccacac gtcttgatta atgtccacaa gtttatgatc taatgtaacg 3075481 agcgacgatt gaaaatctgc ggaaagccga ttcatgaggc ctgatgctct atagcctttt 3075541 gatcattgat attctgggcc tggaggcaag caacaaaagc gccggcctgc tgaagcttga 3075601 cggatgtctg ttcgaataaa tcaagcaacg cggtcagccc ttcagcctct tcaggcgatt 3075661 caggcacctg aaacgcatca gtcctgtctt gaaatgcacg cagactttgt gacagcttct 3075721 caatataacc tttgaattct tccgattggc tcccgccctt aaaaaatgaa tcaagatccc 3075781 atctttggcc taccccttgc agcgccatat cacaaaaccc ctttccttct ttcgttctat 3075841 tatagaacaa ttctgaatta ttgtataaaa atttctatta caggcgtcat ttcgtgttca 3075901 ggatagtaca atagctgtag cagtttaata ggagggttag gatgaataaa aaaatagcca 3075961 tcgtgacagg agcgtccagc ggcttcggtc tgctggcagc tgtaaagctt gcccgatcat 3076021 ttttcgtgat agccacatca agacagcctg aaaaagcgga acagcttcga gaattggctg 3076081 cagcacacaa tgtgtctgat tctattcaca ttacagctct cgatgtcacc gatgaacaat 3076141 ctatagtctc attcggaaaa gctgttagtg cttacgcccc gatcgattta ctcgttaaca 3076201 acgccggaac ggcttatgga ggatttatcg aggatgtgcc gatggaacat ttcagacaac 3076261 aatttgaaac gaatgtcttc ggtgtgatcc atgtgacaaa aaccgtgctg ccttacataa 3076321 gaaagcatgg cggcgcaaag attataaacg tgagcagcat cagcggactg acaggattcc 3076381 cagcgctgtc gccatatgtt tcttccaagc atgcattgga aggtttttct gaaagcctgc 3076441 gtatcgagct gcttccgttc ggtatcgaaa ccgctttgat cgagccgggc tcatacaaga 3076501 catcgatctg gtcaacgtca ttatcaaatt ttatgtcggt gcctgctgac gattcagcct 3076561 atcatcaata ctataaaaag atcctttcct atgttcaaaa aaacggagaa gaaagcggag 3076621 atccccaaga ggttgccgac ctcatttatc aattggcaac aaaacagcac ataaagaatt 3076681 tgcgataccc gatcggaaag ggcatcaagc tcaccctgct gttccgatcg ctttttcctt 3076741 ggtctgcgtg ggagtctatc ctgaagaaaa agctattcag ctgatctaaa ttataattat 3076801 tataatttag tattgatttt tatttagtat atgatataat taagtcaaca gatcacaagg 3076861 aggacgttat cttatgaaaa ctgaaaacgc aaaaacaaat caaacattag ttgagaattc 3076921 actgaacaca caattatcaa actggtttct tttatactct aagctccacc gtttccattg 3076981 gtatgtgaaa gggcctcatt tctttacatt gcacgagaaa tttgaagaac tttatgacca 3077041 tgcggctgaa acagtggata ccatcgctga gcgcctgctg gcgattggcg gacagcctgt 3077101 tgccacagtg aaagaataca ctgagcatgc atctatcaca gacggcggaa acgaaacatc 3077161 agcatcagaa atggtacaag cattggtaaa cgactacaaa caaatcagca gcgaatctaa 3077221 attcgtgatc ggcctggctg aagaaaatca agacaatgcg acagcggact tgtttgtcgg 3077281 attaattgaa gaagttgaaa aacaagtgtg gatgctttcc tcttatttag ggtaacaaaa 3077341 aagctgaacc ttaatcgggt tcagcttttt gttttttctt agcttgaact gctttctgtc 3077401 tgcttggtca gtgttgcgtt caacgttttc gtttttccct ttcgcagcac ttggattgtt 3077461 gttttatctc cgacttttaa gtctttgtaa aggatctgac ggatatccgc actgctttcc 3077521 acgtctttac cgtttagttt gacaatgaca tcctcagatt taatacctgc tttttctgcc 3077581 ggcgaatttg cttgaacttc ttttacataa acacctttgc ccaattgatc tccaaacagg 3077641 ccgagcgtat tttcctgata ggtttcagga acttgtgaca tgtcaatcat ctgcacgcct 3077701 aaaaacggac ggtccacctt cccgttttgc agcagctggt caacaatcgg ctcgacatca 3077761 ttgcttggga tcgcaaatcc aagtgattcc acgccgcttt cgctcacctt caagctgttg 3077821 atgccgatga cctggccgct tgcattgatt aatgggcctc cgctgttccc cggattgatc 3077881 gctgcatcgg tttgcagcac gttcatttcc accgtcccct gtgttgtatc cacatcaatt 3077941 gtccggttca gtccgctaat gataccttgt gtcactgtac cggaaaactg ctgtccgagc 3078001 gggttaccga tagcgattac cttttcgcca gtgcgcagct gtgaagagtc accaaagctc 3078061 gccacttttt ttacattctt gccgctgatt tccaaaactg ccaaatcagt aatggtatcg 3078121 ctgccgacaa gcttggcagt ttccgtttct ccgttgtata gcgtaacagt cagcttgttc 3078181 gcgccttcaa cgacatggtt gtttgtaatg atatacgctt tatcgctgtc ttttttgaaa 3078241 ataacacctg acccggttcc gctttcactt tctgagctgg agcctcctcc cgtgccgaat 3078301 gtgttatttt gagaggtttg gatatttgag attccgacaa tcgtaggctc taaatcctct 3078361 accatatcag cgatgtttga tgcgttcgtt atcggcgccg ttgtaaaatt atcagactgc 3078421 acctgtttat ttgcggaagc ggtttcggtc gcctgatttt ggtctgacgg cagataaggc 3078481 gcgatgccaa gcatgaggcc cccgccgata ataccgccta aaatcgggct cagccatgcg 3078541 gctctccgtt tcttttcttt tttcacagcc gtttcttgct tttccatttc taaagcagaa 3078601 gccgtttcct gccgtcccgc ttcatacgac acaggcgcgt caagcaattc ttgttcagaa 3078661 tgtccaatca gcttctggtt ttctgtattc tgctgttctg tatgtgaagg ttcagtttga 3078721 tgttgatcgt tttggccatc acgtcgataa tccatgttct tacactcctt taacggttat 3078781 tcatttatcg ttacatattc atcgcatgta caagttcaat tgtcccaata atgaggagaa 3078841 aagcaaagca ccaaaataga atatgtttga tcatcctaca tcttcctcgc tctttttctc 3078901 ttcctttctt cccttaacca tatcataaac aaacattgtg ggataaaaat gaaaagaata 3078961 tgtgaaatta tgaaaattgc ctgccgtatg ttaaaactag tttataatga cgttgaaagg 3079021 atgtgaagag ccttgtcata caccatttat ctagttgaag atgaggataa cctgaatgaa 3079081 ctgctgacga agtatttaga gaatgagggc tggaacatta catcttttac gaaaggtgaa 3079141 gacgccagaa agaaaatgac accgtctccc cacctatgga ttctcgatat catgctgccg 3079201 gataccgacg gctatacatt aataaaagaa atcaaggcga aagatcctga cgtgccggtc 3079261 atttttattt ccgcccgaga tgcggatatt gacagagtgc ttggcttaga gcttggcagc 3079321 aatgactaca tttcaaagcc gtttttgccg cgggagctga ttatccgtgt gcaaaagctg 3079381 ctgcagctcg tatataagga agctcctcct gtccaaaaaa atgaaattgc cgtctcctcg 3079441 tatcgggtcg ctgaagacgc ccgcgaggtc tatgacgaaa acgggaatat catcaatttg 3079501 acgtcaaagg aatttgatct gctgctatta tttatccatc ataaagggca tccatactct 3079561 cgtgaggata tcctcctaaa agtgtgggga catgactact tcggaacaga ccgggtcgtt 3079621 gatgatctcg tccggagact gcgcagaaag atgcctgaat tgaaggtgga gacgatttac 3079681 ggtttcggct acaggatgat gtcatcatga aaaacaagcc gctcgcgttt cagatatggg 3079741 ttgtcatatc cggcatcctg ttagcgatat cgattttact gcttgtgtta ttttcaaaca 3079801 cgctgcgaga ttttttcact aatgaaacgt atacgacgat tgaaaatgag cagcatgttc 3079861 tgacagagta ccgcctgcca ggttcgattg aaaggcgcta ttacagcgag gaagcgacgg 3079921 cgccgacaac tgtccgctcc gtacagcacg tgctccttcc tgaaaatgaa gaggcttctt 3079981 cagacaagga tttaagcatt ctgtcatctt catttatcca caaggtgtac aagctggctg 3080041 ataagcagga agctaaaaag aaacgttaca gcgccgacgt caatggagag aaagtgtttt 3080101 ttgtcattaa aaagggactt tccgtcaatg gacaatcagc gatgatgctc tcttacgcgc 3080161 ttgattctta tcgggacgat ttggcctata ccttgttcaa acagcttctg tttattatag 3080221 ctgtcgtcat tttattaagc tggattccgg ctatttggct tgcaaagtat ttatcaaggc 3080281 ctcttgtatc atttgaaaaa cacgtcaaac ggatttctga acaggattgg gatgacccag 3080341 taaaagtgga ccggaaagat gaaatcggca aattgggcca taccatcgaa gagatgcgcc 3080401 aaaagcttgt gcaaaaggat gaaacagaaa gaactctatt gcaaaatatc tctcatgatt 3080461 taaaaacgcc ggtcatggtc atcagaggct atacacaatc aattaaagac gggatttttc 3080521 ctaaaggaga ccttgaaaac actgtagatg ttattgaatg cgaagctctt aagctggaga 3080581 aaaaaataaa ggatttatta tatttaacga agctggatta tttagcgaag caaaaagtgc 3080641 agcacgacat gttcagtatt gtggaagtga cagaagaagt catcgaacga ttgaagtggg 3080701 cgcggaaaga actatcgtgg gaaattgatg tagaagagga tattttgatg ccgggcgatc 3080761 cggagcaatg gaacaaactc ctcgaaaaca ttttggaaaa tcaaatccgc tatgctgaga 3080821 caaaaataga aatcagcatg aaacaagatg atcgaaatat cgtgatcacc attaaaaatg 3080881 acggtccgca tattgaagat gagatgctct ccagcctcta tgagcctttt aataaaggga 3080941 agaaaggcga attcggcatt ggtctaagca tcgtaaaacg aattttaact cttcataagg 3081001 catctatctc aattgaaaat gacaaaacgg gtgtaacata ccgcatagca gtgccaaaat 3081061 agactgtaga tgttttgcag tctatttttt tatgtgaaag aatagccgtt aaaatctctg 3081121 taatttgttt tgagcggctg tttgcattga tgaacccatt ttttctctga caaggtctgc 3081181 ttcggatatt tgactttctc cactttgatt cctctgtttc gcaagcggct gatcatttcg 3081241 tccaattctc tcattctaga ttcacccttt cgcttgagct ttgaccattc ggtcatctca 3081301 atttataata taaataatac atgataaaaa aacaagttac aataaggtta attttataac 3081361 agacggtgtg actatatggt catatcctag caggcctccg ggctccgaaa gggtggaacc 3081421 attgaaggaa aaagaaaaac tgattattga aacagcctta aaactatttg cccaaaaagg 3081481 atacaactca acatcagtcc aggaaatcgc aaaagaatgc aaaatatcta aaggcgcttt 3081541 ttatatttat tttccttcga aagaagcgct tcttctctct atgctgaact actattatga 3081601 taaaacgttt acccgaattt taaatattaa aacgaagggc gacagcccca gaacggctta 3081661 ccgtaaacag ctgaccgtcc tctatgaaaa cattcttgaa cacaaagatt ttatcagcat 3081721 gcagttgaag gagggttctc tgccttacac agaagaagtg gagcaatgcg caaaaaaaat 3081781 ccgccagtcc tcacttcaat ttcatatcga cagcctgctg aacatctatg gaaaaaaagc 3081841 ggaaccgtac actgctgagc tttgtttttt aatagagggc atcagccaga tttacctgga 3081901 atgcatgatt ttgctcgggt acactgtgaa gccgtctcaa ttagctgata tcattatgaa 3081961 tcgaattgat gatatggtaa aaggcatgtc tgaacgaaac gataagcctt tcatcacatt 3082021 ggaagaggcg agctctttat tcggacctct tacgcacgga cggcctgacc cgctgactga 3082081 atcaattgtg aaaagcctac gtgacaaaat taacagctta aacacaaact cctctcttga 3082141 attatcggag agcttggaca tacttgaagc agaaatgaag aaaaaaacac cgaagctggc 3082201 gatcataaaa ggaatgattc ataatctgac ggagtctgaa gctctcgcca aagatgcgga 3082261 acagcttaaa tatttattaa aacagcaaca tatttagaag aacggctgct taaaaagcag 3082321 ccgttcttcc tattacgcct ttggttttac catgtcttcc ggcttaacca tttcgttaaa 3082381 ttgctcctct gtcagcaatt caagcttcaa agctgcttct ttgagcgtca atccctcttt 3082441 atgggcaagc ttggcgattt tcgccgcgtt ttcataaccg atatgcgggt tcagcgccgt 3082501 aacaagcatt aatgaatttg acaggttttc ctgaatggtt tctttattag gctcaatacc 3082561 gacagcacat ttatcatgga atgaattcat gccgtcactg agcagctgca cagattgcag 3082621 gaagttgtaa ataataacag gcttaaacac gttcagttca aagttcccct gactcgccgc 3082681 aaagccgatt gtcgcatcgt tccccatgat ttgcgctgcg atcattgtta acgcttcgct 3082741 ttgtgtcgga ttgactttac caggcataat agagcttccc ggctcatttt caggaatgac 3082801 gatctccccg atgccgcagc ggggtccgct tgcgagccat ctgacatcgt tcgcgatttt 3082861 cattaagtca gccgcaagcg cttttaatgc gccatgcgca taagtgattt cgtcatggct 3082921 tgtcagcgcg tggaatttat tcggcgagct gctgaacgtt tggccggtca gcttagtgat 3082981 ctcttctgag acaagctctc caaactctgg gtgggcgttg atacccgttc cgacagccgt 3083041 tccaccaatt gcaagcgcac gcattttatc tgtcgcttcc aaaatcattt ccttcgaacg 3083101 gtccagcatg tgaacccatc cgctgatttc ctgtccgagg gtcagtggcg tagcatcctg 3083161 aagatgcgtg cgtccgattt tgacaatatc attgtatgct tttgcttttt catccagtgt 3083221 attgcgaagc tgatcaagcg ccggcacaag ctgctcgtaa acagccaaaa cagcggcaac 3083281 atgcatcgca gtcgggaatg tgtcgtttga gctttggctt cggttcacgt catcatttgg 3083341 atgaatcgtt tgatcagagt tcttctcttt taataaagca gtcgcacggt tggctaccac 3083401 ttcgttcatg ttcatattgc tttgtgtgcc gcttccggtc tgccatacga caagcgggaa 3083461 gttgtcatcg tacttgcctt tgagcacatc atcacaaacc gctgcaatcg cttctgcttt 3083521 ttcagcgtcc agattgccga ggcgtttatt agctagagca gtgcttcgtt ttaaaattgc 3083581 aaacgccttc acaacacgca tcggcatttt ttcagaaccg atcttaaagt tctccttgct 3083641 tcgctgtgtt tgggcgcccc aaaatttatc agcaggaact tttacttctc ccatggtgtc 3083701 tcgttcaatt ctgtattcca tttatgtatc cctccataac ggttgcttca atagatcata 3083761 attcgccaat gacacaaaaa atccttttta tttttcgatc ttggcagatt ttaattttaa 3083821 ttcaagatat acgcgggaat cctttgaata tttgtatttt ggatttgtcc tgccgtactc 3083881 ctttgatgta taagagacat cataatgctg ttcaaatgat ctaatgagct gttcaatttc 3083941 ttcttgtttt ccagctagcc ttacctgtgc cacttcgtat cctccgcttt cataaaaaaa 3084001 cttactccat gaaatactct aacacagtat atcatttttt taacaggaaa agataacctc 3084061 tactaaggtt ttggataaga ggtgacctca ttggaacaaa cagagtttaa ggaatatata 3084121 cacgataatt tagcattggt gctgccaaaa ttaaaagaaa acgatgatct ggtgaaaaac 3084181 aaaaaaatgc ttgcgaacgg actggttttt tactatctct atttcagtga aatgactgat 3084241 gagaataagg tgtcagaagc cattaaaact ttgattaaag atgaggagac cttaacgctt 3084301 gaccaggtca aaaaacgcct tgaccagctt gacgcaagac ctgttgaaac tgcaaaaaaa 3084361 acgattgaat cgattctcaa cggcaattgt gctgtgttta tcaacggatt ggataaagcc 3084421 tatattctga ccacaggaaa gaaaaaaaca agaagcctga cagagccgac aactgaaaaa 3084481 gtggttcgcg gcccaaaagt agcgtttgta gaggatattg atacaaatct cgctctgatc 3084541 agacaaagaa cctctcatcc gaaattgatc accaaaaaaa tcatgatcgg cgaaaacaag 3084601 ctgaagcctg cagccattat gtacattgaa ggcaaagcaa aaaagtccgt cataaaagaa 3084661 gtgaaggcgc ggcttaaaaa tatccagctg gaagatatcc aggacagcgg aacgctcgag 3084721 gagctcattg aagataataa atattcacca tttccgcaga tacaaaatac ggaaagacct 3084781 gacaaagtat cttcagccct gtttaacggc cgtgtggcaa ttttggtcga cagttcacca 3084841 tttgtgctgc tggtgccggt ttctctcggc atcctgatgc aatccccgga tgactactat 3084901 gaacgctgga tttcagcatc tcttatccgg tcgctgcgct ttgcttctat ctttatcacc 3084961 ttgtttttgt catcgattta tataacactt gtttccttcc atcaggggct gctgccgacc 3085021 gcactcgccg tcacgatttc ggcgaacagg gaaaacgtgc cgttccctcc gatatttgaa 3085081 gccctgctga tggaagtcac catcgagctg ctaagggaag ccggactgcg actccccaat 3085141 ccgctcggac agacgatcgg cctcgttggg ggcgtagtca tcggacaggc tgctgtagaa 3085201 gcgaatctcg tcagttcgat tttggtcatt gtcgtcagtg tcattgccct ggcatccttt 3085261 accgttcctc aatacggaat gggtctgtct ttccgggtgc tgcgttttat ttcgatgttt 3085321 tccgccgcta ttttagggct atacggcatt attttattta tgcttgtcgt ttatacgcac 3085381 ttaacgagac aaacgagctt tgggtctccg tatttttcgc caaacggatt ctttagcctg 3085441 aaaaatacgg atgactccat tatccgtctc ccaattaaaa acaaaccaaa agaggtgaat 3085501 aatccaaatg agccaaaaac agactccact gaaacttaat acctttcaag gtatttctat 3085561 tgttgcaaat acaatgcttg gggccggact tttaacattg ccgcgagcgc tgaccactaa 3085621 ggctaatacg cctgacggct ggatcacgct gatattagaa ggtttcattt ttattttctt 3085681 catttattta aacacgctca ttcagaaaaa acatcaatac ccttcactct ttgaatattt 3085741 gaaggaaggg cttgggaaat ggatcggcag catcatcggc cttttgatct gcggctattt 3085801 cctcggcgta gccagcttcg agacacgggc aatggctgaa atggtgaagt ttttcctgct 3085861 ggagagaacc ccaattcaag tcattatttt aacgtttatt tgctgcggca tttatttaat 3085921 ggttgggggc ttaagcgatg tgtcgcggct gtttcccttt tatttaacgg taaccattat 3085981 tattttgctg attgtgttcg ggatcagttt taaaattttt gatatcaata atttgcgtcc 3086041 tgttttaggc gaaggccttg gacccattgc aaactccctt accgtcgttt ccatctcttt 3086101 tttaggaatg gaagtgatgc tgtttcttcc tgaacatatg aagaaaaaga aatacacgtt 3086161 cagatatgcg tctctaggat ttctgattcc gattatctta tatatcctta cgtatattat 3086221 cgttgtcgga gctttgaccg ctcccgaggt gaaaacgctg atttggccga ctatttctct 3086281 ctttcagtcc tttgagctta aaggcatatt tattgaacgg tttgaatcct ttttactggt 3086341 ggtctggatt atccagtttt tcaccacatt tgtcatttac ggatactttg ccgctaacgg 3086401 gctaaagaag acatttggat tatcgactaa aacaagcatg gtgattatcg gcataacggt 3086461 cttttatttt tctctctggc cggatgacgc caatcaagtc atgatgtata gcgattatct 3086521 tggctatatt tttgtctccc tgtttctgct tccgttcatt ctctttttca ttgtagctct 3086581 caagaggagg attacaacaa aatgaaaatc cggattttat gtatgtttat atgcacccta 3086641 ttgctgtccg gatgctggga cagtgagaat atcgaggaat taagcttagt gatcggaata 3086701 gggctagaca agcctgacga tgaaaattta gagctgacac agcaaattct cgtgccgaaa 3086761 ataatcagcg ccaaggaggg ctcttcatct gatccgacac agctttctat cacaaagggt 3086821 aaaactgtcc atcaaatgat gagaacctct gcattaaagc ataagcctac gttttcacag 3086881 catttgcgtc tcattctgct ttccaaaagc gtgattgcgg atcaaattgg aatggacgcc 3086941 attattaacc agtttgtcag agacaacgga acaaggagga gttcctacgt ctttatcacc 3087001 aacggccgaa ctaaggatat atttaacatg aatgatgaag gcgaacccgc atccaacgtg 3087061 atatatgatc tgacagagaa taataaggtg acgatcagaa cgatggagcc agttacattg 3087121 ggggagatct cagaacactt aacctctgac gattcattcc tcatccctca tgtcggtaag 3087181 gaaaacggca agctcgcgat aaacggagcc tctatcataa aaaataaatt atggcaccgg 3087241 gacctcaccc cgattgaggt tcaaaatatc agcttatttt caggcactgt cgagggaggc 3087301 gtcattgact tgaagcgcga tggccatctc ttttcttatg aagtatattc aagcaatcgg 3087361 aagatcaaga cggcatacaa ggacggaaag ttcaaattca ccgttacccg caatattgaa 3087421 ggtcgtctat ctgaggactg gaatcccaat gaagactcgt ttaaggattc atatattaaa 3087481 agtattgaaa agacagtcga aaaacgagta cacgaaacag taacgtcatt tattacagag 3087541 aagctgcaga aagagatcaa agcggacgta accgggctgg gaaacgaggt cagaattcat 3087601 tatcctcaaa agtggaaaaa gatttcaaga aaatgggatg atgattattt cagcaatgcg 3087661 gaaatagact accgggtcaa tgtgattgtc agagacttcg gaacgaaagg cgcaaacaaa 3087721 tagcagccgc ctaattcacg agatgatttc ggtgtgcgta caccgccgcc tgcgtccggt 3087781 cactgacatc cagctttgat aaaatattcg taatatgtgt tttgactgtt ttaatcgtaa 3087841 taaacagttc ctcgcctatt tctttgtttg tctttccttc tgcgatcagg cagagtattt 3087901 cgagctcccg ttttgtaagc gattcatgcg ggagcgcgtt ttcacctgag tggcgcagcc 3087961 tggataatac ttttcccgcc acttttgact ccagcttcgg ctctcccttg cttgcggcgc 3088021 ggatggcatc ggcgatttct gccgcttttg aggttttcaa cagatagctg agcgcgccag 3088081 cttcaataac cgggtacact ttgtcatcat caatgaagct agtgagcaca ataattttcg 3088141 ggtcggaaag ctcccggcaa atttgctttg tagcttcaat gccatccatg ccctccatga 3088201 caaggtccat taaaatgaca tcaggcgaca gttccacagc aagccgaaca ccttcgctgc 3088261 cgtccgatgc ttcgccgatg acttcaatat cgggctgcgc ctccaaaaaa gccgcgagcc 3088321 ccattctgac catttcatga tcatcaatca ataatactcg aatcacgttc gttctctcct 3088381 ttttcttccg gaaaaatcgg gaccttcact tcgatttgag tgccttttcc ttctactgaa 3088441 atcacttcgg cgacaccgcc gatttcactt gcacgttctt tcatagaatt caagccgtat 3088501 gaggaggctt tcacctggtc cattttaaag ccttttccat tatcaatcac cttcagacgg 3088561 agctggctgt tctttatgcc cagaatcacg gttacttttg acgcttttga atgtctaaat 3088621 acgtttgaaa gggcctcctg cacgattctg aacaagtggt cttcaacacc cttggatatc 3088681 gctgtgtcct gtatatccca ctcaatatca atcggctgct tttttcggaa ctcgtccaaa 3088741 agctccgtaa ggccctcctt cagccctttt ccttcaaggg taacaggccg taaatggagc 3088801 agcagcgccc tcatctcatt ttgggcttcg cctgccatat gctcgaccat cctgatccgc 3088861 ttgactgttt tgtcatcagc atccttgaca tgttccagca cggctgatgt catcatcgat 3088921 atggcaaaga gctgctggct gaccgcatca tgaagatctc tggccaatcg ctggcgttct 3088981 tctgagataa ccgacttctt catttgagcc tgccattccg cacgttcatt ggaaagtttc 3089041 tggagggatg cgacttgaag ctccacgcgc ttcgccattt cgttcagctg atcagcagcc 3089101 aggccgattt catcatcacc gagcggcggt atccgataag cgaaattgcc gttttcaaag 3089161 gttaaaatgg attcaattaa tgtatcaatc cttgtcttca accggttgcc gtacatatac 3089221 cctgaggcga aaccgacggt cacgctgatc agaagcaaaa tcaggataaa cggaattccg 3089281 aaccagcttg atgacagcaa aacaagcgga tcgagccgat agtaaaacat cataaaggaa 3089341 atcaggcaaa caaaaaggag caggctgatt cccgttgtca tgcggatggc gcgccattgg 3089401 aggctggcaa gcattttttt tctcatacgt acttcacatc cacatcaccg ataaataagg 3089461 aaacggacac ttttacccgg cgctttgact cgctaaaatc agttgacgcg gcatatacct 3089521 tcgtgcttaa tccgcttttc ttcgagccga tcagattaat gtctcctata aaaacagccg 3089581 agctgacagc cacttcaagg tccgatggta cataaatatc aacgttacca atgactccgc 3089641 taatgacgat tgtactttct ccctcgggaa tcatcgcttt agataaatcg attttgatat 3089701 caccgataaa accagagaca tttaaatcgt tcaggtcaaa cggctgcttc atcatttgca 3089761 gctcaccgat aaaaaagctg cgcatgtcgg gatgttttac atcttttggc ggctcatgat 3089821 gttctttttt attgagattg acctgtttct cattcggttc aaatatcggc ttccctttga 3089881 taagcctgta gccggcgtaa atcagaaatg cggcaaacgc atagccgaat aaattaaagg 3089941 tgatgctgaa gaggtttttc aaaaatagaa acgcggcaaa gatatacatg acggagccaa 3090001 gccaatcacg ggaatatttt ttaaggaaat agccggcaat cagaaaaaag agcggccaaa 3090061 acagcagatc gcctattccg ataatttgca aaaacatact gatgccgaat aaagcaatga 3090121 tcaatccgag aagctgtttt tttgtcattc ctggtgtccg cctcctttct tctgcctagt 3090181 gctaccgtat cgctagatcc ccgctgtccg ttttgatgtc gattggatgc cggccgcttc 3090241 cttgcgtgcc tgtgatgtga tgctgttctt tatgtccttt atcagcaaat gaatacggcg 3090301 aactgacgtc accgcttgct gataaagcat tgactgcaaa gctgccattt tggggaaggc 3090361 ttacattagc atcaccgctt gtcagcgtga cagatacggg accggttacc tttttcaata 3090421 cagcattaaa atctcctgaa gtcattttca catcaagaga gcctgataca tgaaccagat 3090481 ttgcgtcccc tgaagctaaa tcaatgccgg ctgttttgga gacggtattt gaaatggaaa 3090541 catcccccga tgatgccttc actttcagat cttgaatgcg gacgtccgtc acgctcgtat 3090601 ttccgctcgc agatactgcg ttcagcccgg aaagcgcaag atggtcattc ccggccacag 3090661 acacgtcacc gcttgaggtt cgtactgcca gatcaccttt ataatcatac ggaagcctga 3090721 cgataagagt tgaacggtta aatccattca aaaattgaaa ttctttttcc tttacggtca 3090781 gctccagttt tcttttgttt tcagtaacaa ataactttcc tgagtctcct gaaatgcctg 3090841 ccgatatgtc acttcgttct tccgctataa tccggacatc cttgctatcc gactcaatga 3090901 ccatgctgtc aatgtcccgc ggcgatgcgc tggctgaatc agcttctgtg ccatttatga 3090961 aacctaggcc tgcagcaaac acatctttta cgacgacggc gaaaaaaacc agaataccgg 3091021 cagtgatcaa cagtttgcca agcatttttt tcattcggtt tcatccttct cattcattct 3091081 attataaagg aaaagcttgc gaattgatac gtgcggaagg gaaggacttg accgcaaatc 3091141 cttccccgtt ccgcttattc atttgccgct tttgtctggt ctgatttttg cagtgaaagt 3091201 gtccgcattt tttcaatctc cgcttccaca tcgtctgcga attctttacg tgtaagttct 3091261 gtgccggctt ccgctgactt tgaataattc gcgcggattt ccatttcttc aatacgattt 3091321 tcaatacgta aaaattcacg atacgcgctt tcactgtcaa ttttgtcaaa tgtcgtattc 3091381 atatgctctt tagctttcgc cgcatttgcc cgcgcaatca gcgcctgttt tttatccttt 3091441 acgtcctgaa gctttgtttc aagtgcagcc agctgctctt tcagatcagc cagctgactg 3091501 tttgcctgtt cataggaagc tttatgctca gccgccttcc cttctaaata cttcatttca 3091561 gtcagcgcct ttttcgccag ttcttcttca cctgcgtcaa atgcgagctg tgcctgattt 3091621 ttccgtttgc cagccacttc agcggcttct tcatattttt tcttaaattg ataggcaatc 3091681 gtgtgctgtt tcacaattgt ttgctttgct tttgcgatgt cgctttccat atcgcgtaca 3091741 tattgattca gcatcacctt tggattctcc attttatcaa gtccttcatg aactgacgca 3091801 acaaacatgt ctctgattct ttttaatacc atacctgatt cctcctaata tattgatatt 3091861 attttttctt caaaaattct tcccattcgt catcaaagtg agattggtag gcagcagaag 3091921 ccggttcagg atcaaaagat gatacaccgt tatcagctga tccgtttttc atcagcttcc 3091981 agccgtaata caccatagcg gccgccaatg cgattccgac gacaaacgga agtgagcaga 3092041 tgagcataat ggctccgata ccgcccacga tgattcccgt gatggttttt cccgcggcaa 3092101 accttttgat tcctgcgtat gtcatcaagc tcccgatggc gagcgggatg ataaagccga 3092161 agcttcctcc tccaaaaaag acggagatcc caaatacaat taataagaat ccgcctattg 3092221 ttttcttgtt tattttcatg cagatcctcc tttcgttttc cttgtcttca tcttatacaa 3092281 gttggaagat atgcaaaacg aatcagagat tgatttttat ataagaccgg agtcgtatct 3092341 cgcaccggac ccattggcac aaaaaaacgc catgcacgag gcatggcgtt ttaaaaccct 3092401 ttacagatga acacttgctt ccctttcttt aattaggtcg gacctttctg ctttggccaa 3092461 ttttgtaaac agcaagattc cgatacccgc aataatttcg acaatcccac cgacagcgat 3092521 cactttacct gagccgaaag cattagcggc atacccgcaa atgacagctc cggcagggat 3092581 cgaaatattt gagatcatat gtataacggc gtaaacctgc ggctgatcct cactatccac 3092641 agacgtctgg ataatcgtgt actcaggaac attaacagca ctgactgcgg caccaaaggt 3092701 aaaagcagcg aaaaagacga gcggcaaaaa ggtattcatc ccggtaataa agaaagcaaa 3092761 tccttcaata atgccggcag tgacgaataa caagccgtac ctgtttacct tgactttcgc 3092821 cagcacaaac cctaataaaa acgcgcccgc ggcggtggtg gcctttaaaa gcgagtatac 3092881 gatcggctgg ccgtttaaat cttccgcaac gtatacggca gagagcgctt cccatggggc 3092941 agccgcgaaa ttcataaaga tacagtaaat ggcgagcgga tataaaatct ggtgttttct 3093001 gacgagccta aagccgcgtt tcagtcttcc gatatatgtg cctctctgtg taacaaccgc 3093061 agactctgat tgagattcaa ccgcagtgta cttaataaaa agaacgagaa aacctgacac 3093121 caaatagagc acaagtgcga taagcatggt ataagaagga ctaataaatg taagaaaagc 3093181 gccgcataat gtgacagccc caagccggac aatttgagcg gaggattgca gcacagcgtt 3093241 tgctttttga atgccctgtt cattgacgat ttgaggaatc aaagcgatag aggcgggatt 3093301 gtaggcagct ccagtagctg aatgcacaat cataagcgtc atgacaaacc acagcggaga 3093361 gaagcccgca aaatgacata gagggataat caaaacaatc gccgcccttg tcagatctga 3093421 aaagtacatc caaaatttca gcgtggtctg tttcataaaa ggccccgtca caggcgccag 3093481 aacggcttcc ggcaaaaacg tgacagcaat caataaagca gtgccgatcg cacctttgcc 3093541 gtcataaatt aaaaaccata atattgaatt aaatgcgaac atatcgccgg atatcttgac 3093601 tattcttgag aaaaacagat aattgaaatt tctcttccag atgctatcac tttcaattaa 3093661 attcaccatc catcagagcc ccccgttgcc tattttttac atctatttat tacaatatct 3093721 catttttcca tttttcagtc aataattcat aaggttcatt ttttgtcgta aaatgggaaa 3093781 ttgacagagt gaaaaacaaa aaaagccggc atgtatttga acacgccggc tttccttttc 3093841 actttttatg attcgctgct gtttcggtcc cgaaacacaa tggcacttct ttcatattct 3093901 acatcgccaa taccgcttct tgcattcaca acccgggcgg cggcaaagaa ataatcggac 3093961 agacgattga gataacgcag cactgtttca tgaatctcct ccgatttcat cagcgccacc 3094021 actcttcgtt ctgcccgcct tgtaatggtg cgtgcgatat ggagaagcga agcacacttt 3094081 gatccgcctg gaagaataaa tttcttcagt tccggcgctt ctgctgtata ggcatcaatg 3094141 cgcgtttcta aaaaggaaac agattcttcc gttagtttat agtcttttct ttctgtgacg 3094201 attgccagat cgcctccgca gtcaaacagc tcatgctgga tggtcagcag ctcggctgtc 3094261 agatcttcaa agccgggctg cccggaaagc tctgccaaag caagcccgat aaagctgtta 3094321 agctcgtcaa tcgtgccgta gctttcgacg cgtaggctgt ccttgtccgt tctgcccccg 3094381 actaagcccg tttgtccctt atcgcctgtt tttgtatata gtttcatacc ctgaatctcc 3094441 tttacagact tattcaaaca actcagcagc ctcttttata cattcagctg tccctttctt 3094501 tatcaattgg ttcagccgct gttctatgtt ttctgattgc tgagtttgag tcgcggcgat 3094561 gagaatatca cctgtgcctc ctccgtctcc cagcactttc gtccgttctg cttcggcagc 3094621 cataagagct ttgatgaaga attgatctgc cgcatagccg ttaatcaaaa tccaaatcga 3094681 aaagccggtc tgaacgcata tgaaaacgga taactctccg tcttcatatg ttcgatacac 3094741 gaaacggtca agtctttctg aagaagccat cgcacacgtc tcctgcagtt gaaaaccgct 3094801 ttctgaaaga caggccgtaa gtccttctat cggatctggc tgatctggca gccgtttatg 3094861 gatcagcgtc ctgctccacg aaaaccctgc accgataggc gtggaggaca atgttcgaag 3094921 cgggatttcc gtttgcagaa gaatgtcatc acgccccgct tggagcaatg cttcaaatgg 3094981 gatagactgc cgcttcacgc tatctttttc aggctgaatc acaatcatcg gtttaggtga 3095041 gctttgatga accaaggcgg tgacatctgt atcgtacacc gcctttatgc tttgttctgt 3095101 aacagcatat tccggttttt gcttaggccc ggcggtaccg tttttcataa acatgagccc 3095161 atcacagtac aggcttgcgg tgttcagatc atgaaaaacg ctgacagctg ccaatccgct 3095221 ttctctcgtc aggcgtttga tcagatcaag caggtctttt tgataagcca gatcgagaaa 3095281 attagtcggc tcgtccaaaa ataaaatacg cggctgctgc gccaaagctt gtgccaaata 3095341 cacccgctgc tgttcccctc cgcttagttc gcgaatcggc ttttgcgcaa aatcggccac 3095401 tcctgtttgc tccattgctt cctgtacaat ggcttcaccc ttttcagtct gctgtctgaa 3095461 cagccccgtt tggaatggat atctgccaaa ggctacagtt tcttcgacag taaaggtgaa 3095521 ggcttgatcc attttttgcg gcaggacagc catgatttgc gccagttcct tcggtttata 3095581 gtccgccagc agttttccgg ccagataaac cctgcctttc ttggccggca gcgtacctgt 3095641 cagcaagtgc aaaagcgtgg tttttccgct tccattaggg ccgagaattc caagaaattc 3095701 tcccttctcc actgttaagc tgacattgtt gattaggcgg ctgtcgccgt atcctcccga 3095761 cagcccttct gccttcatca taagcttctc cccccgcgat gctgccgaat taaaataaga 3095821 gcgaacacag gcgctcccgc caaggacgta atgatcccga tcggcagttc aatcggctca 3095881 atgatggttc tggaaagcag atcggctaaa acaagaaacc ctgccccaag caaggcggac 3095941 aacggcagta aatgccgatg gtccgttccc cacaaaagcc ttgtgatatg cggaatcaca 3096001 aggccgacaa agccaatcgt acccgatact gccacagcgc ttcccgtcaa aagagatccg 3096061 gctattaaaa tcatcatctt cctctgctga acgctgactc caagaagctt tgctttatct 3096121 tctccatatg tcatcacgtt cagttccctt ccgtttataa tcaataaaat ggttcccaaa 3096181 agaaaaaacg ggagaaacaa aataacatag ctccagcccc tcattgagac gctgccaagc 3096241 agccaatgca caatcggaag caggttgtct cctgtcaagg cgatgataag agaaataaat 3096301 gcgcctaaaa aagagttggt gatgacaccg gtcaaaatga gggtggaaac agacatcgaa 3096361 gcatgaacga ggcggctgaa gaaaaggacc gccgccatcg tggccagtgc cgcggctaca 3096421 ctcaaaaccg ggagtgtaaa ccctccgatg acaggaaggt gcaaacctaa gaacagagtc 3096481 acaacagctc cgactgaagc accggatgac acacctagcg tatagggatc agcaagcgga 3096541 tttttcaaca atccttgaaa agcggcccct gcaatagaaa gagccgcccc cacaagggcg 3096601 gccagcacaa ctctcggcag tctgatattc atcataatat tagtgtacat cggatcatca 3096661 gaaccgatag agccgccgaa accttgatgc caaaagacac gaaaaacagc gggaatagga 3096721 atatgcaggc tgccgcaaga aattcctaag atgatgctca cggctaaaaa tgagaaacca 3096781 atgatatatg cggcataacg attattcctt aaacgtatcc gggtaaatgc tttccgcaag 3096841 ttcttcgacc ccttcgatca gacggggacc ggaacgtgtc acaagatcag ggtccacatc 3096901 atatacacga tgatgtttca cagcattgat ttcgctccag ccatcgcgtt tttccacagc 3096961 tttcgctttc acaccgtccg ttgtaacaat tgcatcagga ttgagtttta cgatcgcctc 3097021 gtctgtcatt tgcacccatc ctgtctgatc cgcagctgcg tttttagcat ggatgacatt 3097081 tagcatttca ttcataaacg tatcttttcc ggttgtataa atgtcaggat caggagaaac 3097141 ctcgataaat acgcttttct cctcgtcttt tgaaatggtt ttcgcttttt cttgaatatc 3097201 ctttagatct gatttcatgc ttttcacgag ctgatcggct tttttctccg ccccgccagc 3097261 ttctccgatc atttcgattg atttgtacac ctcggagaat gattgtgcat cattgacagt 3097321 cagcactgta atgcccgcgt ccttcagctg tttgatggca tccgctgatg ctgacatgga 3097381 agactcatgg gccagaacga gatctggttt tagagaaatg actttttcaa cgtttacatt 3097441 catatctccg actttctcaa cctttttgac ttcctttgga taggtatcgt ttgtggtgac 3097501 accgaccact ttgtcaccaa ggccgagtgc gtatgtaatt tctgtgttgc tcggcattaa 3097561 tgaaacaatc ttttttggct cttttttgat ggttacatct tggtttgacg catcatcaat 3097621 ggtgacaggg aacacttctg ttttttgttt tgcctttgaa tccttctgat ccgcaggatt 3097681 gccgcagcct gccagcataa cagcagccaa cagaagcgca gcccatatcc cggctcgttt 3097741 tttcataatc ttttcctcct aaacgaacta aaaaagcatc tctacgacgg taaagatgct 3097801 gtaaacaaca caaaaaagcc tattgtttac acatcatctg tcctcgcaga attcgtgctg 3097861 atcaaacagg caggtatcct ggctcttggc gcttggccaa ttacagtggc gggaccgcac 3097921 cggcttttac cggtttccct tttaagccgg ctgttgttca cggaccggca cctatttgac 3097981 attcgtatcc gtttttcgga gtaattatac tatatgactg acaggcttgt atatgtgtcc 3098041 tgaatgactt ttccccatat tgtgtatgga agcaaaatcc tcgtaaacac taaatttgat 3098101 cttgtatact taataccatc atctatcaaa aggaatgatt cttatggatt tacagctaaa 3098161 agaaaaactc gtcttaatca ccggctcgac gtccggtatc gggaaagccg ccgcaaaaag 3098221 ctttctgcaa gagggtgcgg cagtcattgt caacggacgc aaacaggaga ctgtcgatcg 3098281 caccattgaa gagctttctg gctatggaac agtgcacggt gctgctgccg atttgtcaaa 3098341 aacagatgaa gcagcggctt ttatcgaaaa agtaaatgaa atcggtgata tcgatatcct 3098401 tgtcaacaac cttggtttct tcgaggtaaa agacttcgcc gatgtgacag atgaagagtg 3098461 gaatcaatat ttcgaagtga acgtgatgag cgccgttcgg acaagccgtc acttccttcc 3098521 aaaaatgctt gccaaaaaca gcggccgcat tttaaatatt gcaagtgaag caggcgtcaa 3098581 accgctgcca acgatgattc catactcaat gacaaaaacg gcactgatca gcctttcaag 3098641 aggaatggct gaaatgacaa aaggcacaaa tgtgacggtc aactcagtgc tcccgggacc 3098701 tacttggaca gagggcgtgg cctcctatat ggaaggcgcc gcacaagcag ccggacagga 3098761 tacagataca tttatcaaag actatttcaa ggtcaatgag ccaacctcac ttattcagcg 3098821 atacgcgaca gcagaagaag tcgccaacac aatcgtattc ctcgcgtctg acgccgcatc 3098881 cgccattaac ggcacggcac agcgtgtgga aggcggcatt atccgttctc tgtagtataa 3098941 aaaaacgcat ccgtgtttcg gatgcgtttt ttttatacgt ctccagcaaa tggtaccggc 3099001 tgatatccgc ctgtttccag ttgtgctgaa aacaaccctc cagcgtgagg ctgctcgtat 3099061 ctctcttttt ctgtcatttg ttctgttgcc gttgtaatgt aaagggtttt taagtctctg 3099121 ccgccgaacg cgcagcacgt gacatattta gccggcacgc tgattgaatt gatttctttt 3099181 ttctgaaacg ggtcaatgtg aacaacgcgg ctgccgccaa acagcgccac ccacagcatg 3099241 ccattttggt caattgtcat gccgtccggc aatccgtctg actgatcaaa acgatagaca 3099301 ggttctggat tcgaaacatc tccgctttga ggatcatagc tgtaacgtac aatctcctgg 3099361 gtcggcgtgt cgatgtaata catcaaattc cgctcgcggt cccaatccaa accgtttgag 3099421 gtggagactt gatccttgat tttgacaaga ctgccgtcta gattcaaacg gtacagcgac 3099481 gcctgttttt gctcgccttc catgctcgtc gtccccgccc aaagccttcc gtacgggtca 3099541 catttagcat cattaaatct caggctctca tgcatgtcct tcggctgttt aattttttcc 3099601 aagctgtcat cccgaagatg atacaggtaa aacccgtcct tcatcgtcat aatcagttca 3099661 tcctttgaat atttcgcaag cgccgtcaca aaggatttga atttgattga tcggttgatt 3099721 ttttcttcag ggtcaaagat gtggagctcg ctccccagga tatcaaccca atataagcgg 3099781 ccgttctctt catcccataa cgggccttca ccaatcactg cccgagtgtc tgcttccaat 3099841 actgcatcca tgtgttacac ctctttagct tcagtctata tattgttatt cccggcaaag 3099901 aggtgtccaa accacttgat gtttattgtt ttttaaaaag gatggtaatg accgttccaa 3099961 tgttcgttct gctgttcaca tggatcgttc cgttatgcag atggacaagc tccttggcaa 3100021 tcgcgagccc gagacccgtt ccggcagttg aatcttttgt gttcgtccct ctgtagtagc 3100081 ggttaaacaa atgggtgatc gtttcttcat ccattccttt cccattgtcc ttcactttta 3100141 aagaaatatg attttttgtt tgctccagaa tgacttgaat ctctgttcct ttgccgttgt 3100201 gcttcacggc attcccaagg aggttttcta atatgcgcct gaaccacgct tcatcaaggg 3100261 caaattcaat atgctcttct ttggatacaa acgagatatc atagccttca gaaaacggat 3100321 ttttcttaaa atcctcaatg acatttttaa aaaacgggat aaggctagtg agctttctct 3100381 caataggaag agcatcattt ttcaggcgat acgttaaatt taagtcttca atcagcttag 3100441 acatgtattc agatttttct ctgacaacct gccccatttc tttcacttct tccggcgacc 3100501 agtcatactg cttcgactcg agcatcatgc tgtagccgta aatgctgctg agcggtgttt 3100561 ttaagtcatg tgacaaaccg gcaatccatt cttcccttgt cgcctggatt ttttctctgt 3100621 ttcttttatc ccttctcagc gtttcagtca gctgatccat tgattcaaat atctcaccga 3100681 agaagcggta cggctgtttg atttttccct ttttattttt gctgacagga cggccttccc 3100741 ggtttctggg ctcctcaagc ttcccttttg acagattgac cagccatcta atcgtgtgaa 3100801 aaatcggcag cccgaatcgg aacatatacc aaacggtcat ccaaatgata tacatgaaca 3100861 aaacggccat cacgagaaac atcgctttta atacaacctt caggaatgat ttgttaaact 3100921 cctgatcggt tacatagact gggttcggca ccgtagcgac catccatctg tctttattga 3100981 ggatcttaac ggaaatttcc cgcttatagt tccaaggctt agagctgtat ttaagcagct 3101041 ccagctggtt catcgttttt ctctcgcttt ttgtgctgtt gatgctgtcg agaatctttc 3101101 cattgctgtc taacaggtaa atggcgcctt ttttccgttt aatatagtcg atggtactag 3101161 acttatagtg cgctagtgag tctatctttt gttcacgctt ttcaacggaa gtcaggagct 3101221 gttcactttt tgatttccag ccggacaata gaagatacga cttatcttca atattgatgg 3101281 cccaataatt cagtttatag ttatgaagct ttttggtttt ataaatagac aaaagctctt 3101341 tcttggtata ggtgcccggc acgtcttttg gcacgccgta ggaataatca gtgtttcctt 3101401 ccgaatcaat gatttgcatc cagccgtgct gtttatcaac agatttcttc aggaaattat 3101461 ccacttccca tgtcccgtct tcgtttacat cgagatatgc ctcaagtgtg tcggtcgttg 3101521 ctttcgtcag ccctgaattg gattccgcat cgctaaaacg ggcgtctaaa tagaaaaacg 3101581 atgcaacaag cataaccgta agcagcagga tcacaatcag catctggccg aaaaagtgaa 3101641 acaaaaactt ccatcttaac ctcatgaccg cttgccttca ggatttggga taaaacgata 3101701 gccgagacct cgaacggtta caatatactc cggattgctc ggatcgcgct caatcttctc 3101761 cctaagcttg cgaatatgaa ccatgacggt gttgttgtca ccgtaggaag gatagcccca 3101821 tactttttca tatatttgat ctttggaaag caccacgtta gggtgttcac aaaaatactg 3101881 caaaagctgc agaagctggg ctgaacaggc aacggcttcc ccgcctacga tcaactcggc 3101941 attttgcgga gaaaaagtaa agtaatcata tgtgtaggtt tgatttgaac tcgtttcttt 3102001 cgattgatat gtacgcttga gatgcgctct gatccgcgcc gctaattcca gcggattaaa 3102061 tggttttgtg atatagtcat cagctccaac cgcaaagccc gataatttgt ccgcgtcgga 3102121 tgatcttgcc gtcaggaaaa aaatcggagc gtctgaatac tctctgatca atgtgcaggc 3102181 ttcaaaaccg gacattccgc ccatcatgac atccagcaca atcaagtcaa ccttattggc 3102241 cttcacaacg ggaatcgctt cttctgcgct tgccgcatcc agtatatttc gataaccttc 3102301 tttttcgaga acgcgtttga tcatgtccac aatcgctttc tcatcgtcta cgattaaaat 3102361 tgacgcattt tccactttta tgttcctttc tgtcactgtt tttttcatct tatcattata 3102421 tcgtttattt atggtacatt tttgaataca ttggagcctt ggcaaatcaa aacagcaaaa 3102481 aaggagcaaa caagcgctcc cttttgatgt tttttcatat gaaaatatta tgagttctca 3102541 tctaccatgt acaaaataaa ctcccaaaac cccggtacat cctgacataa aagcatatca 3102601 gccttttcaa acattttgat cttcagctct tgctctaaat cttctctttc ttgataggac 3102661 gtattgctga gtttttttct gatcatcggt gaaaagcatg caatcaggtg ctcaatgtca 3102721 taagtctcgt ctttttgttt ctttttttgt tcaaactggc cgtccacagc ttacttttcc 3102781 cccttttttt gcgccgctaa ctgctttctg atattctcca gccccttttt atgaatgttg 3102841 gagatgtttt gtcgggactc ccctaatgaa tctgcaatct cctgcatcgt ggcaccgtga 3102901 agatagactt tcgtcagcac acttttttgt ttgtcagtca gcttctggat cgcttggtag 3102961 agctggtaat cctgtacatg ctggctcaaa tcatcctgcc tgtctaaaaa ttcttcaaat 3103021 gcatcgctac ctgtttcgga agaaagccga tctcccgcct ccggatgatc aaccgtcagt 3103081 ggataccgtt tttggttttt gcgaacccgc ttatcaaaat caatagaaaa gatgcgaatc 3103141 attgaattca tatacttgac gatgcggatt tctttataaa attgcttaaa tagctcgtcc 3103201 aatgatcttg catctttttc gttagggctt tccattacgt ttttgaacaa acggtaatgc 3103261 tgaggattgc tcaaaaaatg cttcacgatg ggatgcttca ttatctcctt acattttgac 3103321 cgtaaaagac tttgatagtc catcaaaccg cctccctact aaattaaatg aaggaaagca 3103381 aaaaaaagta aactactact ttccgcctag tgtcttccaa aatactttgc agcagtttac 3103441 gttttatcgg ttttcctcac ttacatacat gactgcagaa aaagaaggga ggtattttcc 3103501 tatggatcag gtttttatag aggaagtcgt aaaacagatc ggcaatttgg ggtttcccgc 3103561 gctgattgca atgtatctgc tgacccgatt cgaaaagaag tttgatcaac taatagaact 3103621 aatgacagaa ctgaaagatc atgcaaaaaa ataatttttc aatcgaagtt gacttttcac 3103681 tggttttttt cacttaacaa aacagaaggg aaaacgaaag gcctttcacc ttctctttct 3103741 gctatcacat ttaaatgtaa ggaggaaaca tttcatgaaa aaacaaaatg acattccgca 3103801 gccaattaga ggagacaaag gagcaacggt aaaaatcccg cgcaatattg aaagagaccg 3103861 gcaaaaccct gatatgctcg ttccgcctga aaccgatcat ggcaccgtca gcaatatgaa 3103921 gttttcattc tctgatactc ataaccgatt agaaaaaggc ggatatgccc gggaagtgac 3103981 agtacgtgaa ttgccgattt cagaaaacct tgcatccgta aatatgcggc tgaagccagg 3104041 cgcgattcgc gagcttcact ggcataaaga agctgaatgg gcttatatga tttacggaag 3104101 tgcaagagtc acaattgtag atgaaaaagg gcgcagcttt attgacgatg taggtgaagg 3104161 agacctttgg tacttcccgt caggcctgcc gcactccatc caagcgctgg aggagggagc 3104221 tgagttcctg ctcgtgtttg acgatggatc attctctgaa aacagcacgt tccagctgac 3104281 agattggctg gcccacactc caaaagaagt cattgctgcg aacttcggcg tgacaaaaga 3104341 agagatttcc aatttgcctg gcaaagaaaa atatatattt gaaaaccaac ttcctggcag 3104401 tttaaaagat gatattgtgg aagggccgaa tggcgaagtg ccttatccat ttacttaccg 3104461 ccttcttgaa caagagccga tcgaatctga gggaggaaaa gtatacattg cagattcgac 3104521 aaacttcaaa gtgtctaaaa ccatcgcatc agcgctcgta acagtagaac ccggcgccat 3104581 gagagaactg cactggcacc cgaataccca cgaatggcaa tactacatct ccggtaaagc 3104641 tagaatgacc gtttttgcat ctgacggcca tgccagaacg tttaattacc aagccggtga 3104701 tgtcggatat gtaccatttg caatgggtca ttacgttgaa aacatcgggg atgaaccgct 3104761 tgtcttttta gaaatcttca aagacgacca ttatgctgat gtatctttaa accaatggct 3104821 tgccatgctt cctgaaacat ttgttcaagc gcaccttgac ttgggcaaag actttactga 3104881 tgtgctttca aaagaaaagc acccagtagt gaaaaagaaa tgcagtaaat aaaagacttg 3104941 cggcttgcag agagcactcg ttctctgcaa gccttcataa ggagctgaac cagtgaaaca 3105001 tcaaaaccct tcaaaacgct tattgcggct ctccataaag tacttgctgg ccgcagcagc 3105061 agtggtgttg acctattttg ctgtcatcta tatattgttt tctttagcgg gaacgagcta 3105121 ccgctcagca gctcatgtcc tgctttttgc cgtggtattc cttgttctcg gattatgctt 3105181 tgaaccattt gaacggctga tgatacatag ctttacattt ttcaagacag gaaaacgtct 3105241 attcattctc cttgctggca tcgtacagct gctgtttttg tggatgactg ctcatacaac 3105301 agaccaattg atcagcgaca tctggctgtc caccacagaa gaaatgattg tcgcagccgt 3105361 ttttttgatt ttagacaaat gcaactcggc tcttcccagc taaaaaaaga acgcattcca 3105421 attggatgcg ttctttttat tcatagcgaa gcgcgtctac aggctgaagc ttcgaagcct 3105481 tgatagacgg aagcaagccg aagataatgc cgactgccat tgaaaagatg agtgctccga 3105541 caacagctgg aatggagacg ataaaaggca tcggaaaaat gaccgtcagc agcttggcga 3105601 tgccgaagcc cgccagcaca ccgagtattc cgccaatgct tgtcagcacg acagcctcgg 3105661 ttaaaaattg aaataaaatc acacgccgct tagcaccgag cgctttctta attccgattt 3105721 ccctcgtgcg ctccgttacg gaaacgagca taatgttcat gacgccgata ccgcccacca 3105781 aaagtgaaat actggcgata ccgccaagca gcaatgcaaa tgactgatta aaggactcca 3105841 cttcctgcgc gatctcctga agatccatta cactgtactc tgctttttcc agctcagctt 3105901 ctgacagtcc ctgatttaaa agatctgcag ccattacacc cgcttcttgg atatgctcag 3105961 aagaatcagc ctgcacggca atctgcgttg gcgcgtcaaa tccttcaata agcggccaca 3106021 cttttttcgg cacgtacaaa accgggttcg catagtcgcc ttcaaacatg ctttcctgtt 3106081 gatttttttc tttaaaaaca cccacgacct taaacggcac accattcatc tcaatgcttt 3106141 tatgcagagc ttctccgtct ggaaacagtt catctctgac agcttcattg atcatcacta 3106201 cttggtgtgt gctgtttaaa tcgttttccg tcagctttct cccttcggtt attcggattg 3106261 gaaacatgtc gaagtaatca tcgtccactc catacacttg gggatacgaa acgttagtta 3106321 aatgaaaaac gctcgcgcct tctgacaagt aatataagga taatcctttg accatcggat 3106381 ctgatttgat cgcctttact gtttcttccg ctacaggcgg cgcggacgca tacgacacct 3106441 gagggccgcc gctctcctct tctccgccag acggctggta gacaacattg atggcgttgt 3106501 ttcccatgcc gatcatactt tgctttaact gctcactttg gcccttcagc attgaaacaa 3106561 tcgcgatgat tgccgctatg ccgataatga cgccaagcat tgtcagaatc gatcttaatt 3106621 tatgagagaa aatggattga aaggagattc gaatatgttc aagcatggct gatatcccct 3106681 ctctcatcta ataccaactc tccgtctctg ataaaaacgg ttctgtcagc ttttttggcg 3106741 acgtccgggt cgtgggttat cataataatg gtcttgcctt cccgatgcag ttcagaaaac 3106801 agtgccaaaa tttgttcact tgatttggta tcaagcgccc cggtcggttc atcagctaaa 3106861 ataaacctcg gctgattgac aagggccctc gctatcgcca cccgctgctt ttggccgccg 3106921 gacagcttag gcggtttgta ggagaccctg tcttttaatc cgactttttc cagcgcttca 3106981 tatgcccgtt gccttctctc ttttttcttc actttattgt agatcatcgg cagctcgaca 3107041 ttttgcagcg cggtgagacg cggcagcaaa tgaaaagttt gaaacacaaa cccgattgat 3107101 tcattgcgaa tttcggctaa agccccgtct ttccctttca atatatcgat ctggtcaagc 3107161 gtataggttc ctgaggttgg cctgtccaaa cagccgataa tattcattaa cgttgacttt 3107221 ccagaaccgg aaggccccat aatagctaaa aactcccccg cctgaacggt cagattgata 3107281 tgtttcaaga ttggaacttc ttcttttccc agcttgtacg acttcgaaat attattcagt 3107341 gtcagcattg actgtaacct gctttccttc cttgaccgcg ggatcaggat agatcacata 3107401 atcttccggc gtcaggccgc tcttaatttc caccatgtca ttttcatcag tctctccgat 3107461 ttcaacaggc tgcttaaccg ctttgtgatt ctcatcagct ttccatacgt acggttcgcc 3107521 gtcatcctga atgaccatgt cggacggcag cttgatcgtg tccgcatcag cattatcact 3107581 catcacttcg atgttgacat gatagccgac ttcaagacct ttatggctgt ctaataaaat 3107641 ggtgaaagga tagttagagg actggggatt catttcttca tcagcaaagc tttctgattc 3107701 ttcaccctcg cctgctcccg ctggaagctt gccgatcgag gtgacctttc ctttccactc 3107761 gccctcaccg cctgttttca gcgtgaccct gactttgctg ccttttttga tcgtgtccat 3107821 taacagctca ttgatttggc ttttgaccag atatttgcct gtcgaaacaa tctggatata 3107881 cgggcctgct gcctggtcgc ctgttgcacc gtcagcgata tcctgattga cgctttgaac 3107941 gattccgtca tgcttgcttg taatgacatt ggaacctttg tttttcgtca ggccagccag 3108001 ttctttttga tgctgcttca gttcaagctg gcttgttttc aaatcgaaat tggtttgatc 3108061 aagttcatct tgaagctggt ttttctcttc ttttcctgca actttcagct ttttttccgt 3108121 ttccgttatt gatttttgca aacggttgat ttgcagattt gtcatttcaa tttgcaaatt 3108181 ggcttgctcc acttcatcag aatgatcctc gccctcatac tcaaaaagct tatcgccctt 3108241 tttaacctga tcgccttctt tgacgtatgt ttttttaatg ctgccttttt ctgaatctat 3108301 gtatactttc tgctgtttct caggttcaac ctttccagaa aacgtttggc ctgattctga 3108361 atctcctccc atgtataccg cgaccgattc agcatagggc tccgatgata cggcaacttg 3108421 gttcatgtga gtaaaaaagt aaaaaccgcc agcgccgatc ccagccaata caagcacacc 3108481 ggcacatatc gcaccgccaa taagccattt tttcttcttg gacacaacga tctcctcttt 3108541 ctgtaaacta tgtaatattt tcgaaacatt ctaaccaata ttatctatta attcaaaaag 3108601 acttgcaatc cttttattga aatgacggaa tcaaatagaa aaattgtatt ttcaaagccg 3108661 aataaaaaaa atcccggctt caaaccggga ttttttcata cagtaactag ctctttttca 3108721 tttttaatca agtcatatgt caagcataca ggtttatttg tacggggatc agtcacgatt 3108781 tcggcatcaa tctgaaatac ctgcttcaaa atgtctggtg tcatgacctc cagagcagtt 3108841 ccttccttga tgaccgtgcc ttttttgagc gcgatcatat aatgagaaaa acgagctgca 3108901 tggttaagat catgaatgac cattaaaatc gtccgccctt gctctttgtt gagtctgtca 3108961 agcagctgca gaatttcaag ctgatgtgca agatcaagat acgttgtagg ttcatccagc 3109021 agaagcagtt ccgtcccttg cgcaagcgcc atggcaatcc acacacgttg acgctgtccg 3109081 cctgacaatg cctcaatcgg ccgttcagca tattcagcca tgcctgtttc ttcaagcgcc 3109141 catttgataa tccggcggtc ttcgtcattt aatctgccga atcctgattg atgcggaaac 3109201 ctgccgtacg acaccaattc gtgcactgtt aggccgctcg gcgcttcagg tgtctgtgga 3109261 agaatcgcca tatcttttgc aatgtccttt gtagacattt tatgaatcgc tttgccgttt 3109321 aaatagacgg cacctgcatg tgaacgcata attctggaca ttgtttttaa aatcgttgat 3109381 ttcccgcagc cgttcgggcc aattaaggtg gtaattttcc ctttaggaat cgatatattt 3109441 aaatcctcta caatcaccct gtcgccataa ccgattccaa gctgttccgt tgataatgaa 3109501 ttcatattcg gccccctcct ctaattcgct ttcatcaata aataaataaa gtaaggcgca 3109561 cctagcacgg aaatgacaag tccgaccgga atttctgatg gtgccaatac atttctcgcc 3109621 agcgtatcag caagcaaaaa caggaatgag ccgatgaagg cggagaccgg tatcagcgtc 3109681 tggtgacgtg gaccggtcag ccttctagcc acatgcggcg cgatcaatcc gagaaacgca 3109741 atgccccccg cagctgccac gcatgaagcg gcaagagtga ccgctgccag aagaagaatc 3109801 cgtctttcct tttcaacagc ggtgcccagc ccggtcgcca attggtctcc gagctgcata 3109861 atgttcaaat agcgtgcctt atataaagta aacagaagca agatcacaat ccaagggaga 3109921 atcgcccaga tcatattcca gttcgccccc catattgagc cggatatcca aaccgcggct 3109981 tgcataaaat catgagggtc catcttgagc tgaaaaatca gcaacagggc gttgaatccg 3110041 gcattcaccc ctatgccgac taaaatcagc cgaatcggtg tcacgccttt tttccatgcc 3110101 agaatataaa tgagaaacgc agcgaggatt gctcctgcca aagcactgaa cggcagcata 3110161 aatgttccga aaaagctaag atctgaagct gacccttgaa aaaagtatat aaaaagcact 3110221 acagcaagtg aaccgccggc gttaattccg agaataccag gctcggcaag ttcattttga 3110281 gacacgcttt gcaaaatggc tccagctacg gagatccctg ctccaacaag caaagaaagg 3110341 atgatccggg gcagcctgaa ctcaaataag acaagttcat cacgcgccgt tccttggccg 3110401 aaaaagacct gaagcgtttt aagcggtgca attttgataa cgcccaaatt gagactgata 3110461 aaaaagacca ccacgataag caaaaaggtc acagccatta caatgagcgg tttgtttgtt 3110521 tttgttttca ttacagccct ctcctttcac gacgtgccaa ataaaagaaa aagggaacgc 3110581 cgataagaga agtcagcgcg ccgacaggcg tttcaaaggg cgcatttacg agtctggccg 3110641 ctatgtcagc aaaaacaagc aaaacagcac cgagcaccgc cgagcaagga atgatccacc 3110701 gataatccac accgaccaaa aaacgggtaa tatgcggaat gatcagcccg ataaatgcaa 3110761 tggtgccggc aatggaaacc gcagctccgg tcagaattac tacaataagc atgccaacca 3110821 gtttcaccgc tgatgtatat tgtccaagcc cttttgccag atcgtcaccg agacttaaca 3110881 ctgtaacaga ccgggcgatg aaaaacgcga gcgttaaacc gacagcccct gcaataagca 3110941 aaagctggac ccccgaccat ttcacacccg ctaccccgcc tgcgtaccaa aagctgatat 3111001 cctgagcgac atcaaagcgg attgcaatgg cagttgaaat gccggtaaag aaataagtaa 3111061 ctgccgtacc cgccagagca agctttacag gcgtaagtcc gccccttgaa aacatgccta 3111121 tgcccattac cgtcgatgcc cccagccccg ctcccgcaaa ggaccatagc acaagcccca 3111181 ttgcagaaag tccgggaaaa aaggcaaacg caatcgaaac cgcaaacgca gagcctgatg 3111241 tcacacccat aatcgaaggc tctgccaaag ggtttctcgt catcccctgc atgattgctc 3111301 ccgacactgc caacaatgcg cctacaagcg cggcagccgc cgttctcgga agccgaagat 3111361 catgtataat ttggtgagat gtctttgtcg gctgataatg aaaaatggcc tcccatacag 3111421 tgcgcaaatg aatatccgct gcacctaggg atatggataa aaatgcgcca aggcaaagca 3111481 ggcatagacc tgcgataagg acgatgaccg cgccatatgt ccttgacgtc cattggattt 3111541 cttctgatgc agtccgtata tttttatgtt gactcaactg ccgtacttcc tttctgttac 3111601 tgataatgat tatcaattgc tgtttcagta tatcactttt ttcagctgat ttaatagagt 3111661 gttttgaaca aaaatgaaaa tgcatttgca aaaatatcgt gtcaaccggc acttgcagtg 3111721 gtataatcac agatgataat gattctcttt ttcatctatc ttttagaaag aaggtatgag 3111781 atatgaccca tatatacaag aaactcggag ccgcgttttt tgccctgtta ttgattgcag 3111841 cgctggcagc ctgcgggaat aactcagaaa gcaaaggttc tgcctctgat tcaaaaggcg 3111901 cagaaacctt tacatacaag gctgaaaacg gaaatgtaaa aatcccgaag catcctaaac 3111961 gggtggttgt catggcagac ggctattacg gctacttcaa aacactcggc atcaacgttg 3112021 taggtgcgcc tgagaatgta tttaaaaacc cttactacaa aggaaaaacc aacggcgtcg 3112081 aaaacatcgg agacggcact tcggttgaaa aggtcattga tttgaaccct gacctgatta 3112141 tcgtctggac aacacagggc gctgatatta aaaagcttga aaaaattgcg ccgactgtcg 3112201 cagtaaaata cgataagctc gacaacatcg aacagctgaa agaatttgca aaaatgacgg 3112261 gaactgaaga taaagctgaa aaatggctgg ccaagtggga taaaaaagtt gcggccgcta 3112321 aaacaaaaat caaaaaagcg gtcggtgaca aaaccatttc cattatgcaa acgaacggaa 3112381 aagacattta cgtatttggt aaagactttg gaagaggcgg aagcatcatt tacaaagacc 3112441 tcggcctgca ggctacaaag ctgacaaaag aaaaagccat tgaccagggg ccaggttata 3112501 caagtatttc attagagaag ctccctgact tcgccggaga ttacattttc gcgggcccat 3112561 ggcaatcagg cggtgatgat ggcggcgttt ttgaaagctc catttggaag aacctgaatg 3112621 ccgttaaaaa tggccatgta tacaagatgg atccgatcgg attctatttc acagacccga 3112681 tttcattaga aggacaactg gagtttatta cggaaagctt gactaaataa acaaaagagc 3112741 cgcctgcccg cggctctttt gcttatttat aaggaacggc tcaatttgaa tcatatcgga 3112801 tattttcttt gagccattca tattaagctg catcctcatc acgatcagtt tttttatgct 3112861 ggagagactg aaaaacgttt tttgcatatt taacgaacgg attcctaaca ggagaaattg 3112921 tgattttata aaaaagacac ctgagcaaat caggtgtctt ttcattatgc ttgtttttct 3112981 ttctggaact tgttactcac aaatggataa acgattaagc cgacaaagaa taaaccgatg 3113041 ccgagtataa atgtcgttaa atctgctgtg cctgttacga taacaaacac ggagtatgca 3113101 cacgccagta tcgcgatcaa tccgtctctt acacgggagc ctttcagctg gtcatacgtt 3113161 tcacctttga tgactacctt caagctgtag attgcagata ccagatacgg aattaaatat 3113221 gcgagtgtag ccgctgtcgt taaaaatgta aatgcgtcac ttattgtccg ggaaataacc 3113281 gagaaaatga agacctgtga catgacgttt gtaataatga gtgcaatgac cggacttccc 3113341 tttttattcg tttttgcaaa aaatgccggg aaatctcctg ctttagcggc ttggtatggc 3113401 acctcagagc caagcaaaat ccagccgagc atcgttccga ataaacaaag gatagccaaa 3113461 agcgccataa tcacgcttcc cgcgtttcca acaatcgcat agagtacatc aacaaatggt 3113521 ttttcagagc cgacaagctt atcatgcggc agaacaccca tcgtaattaa agtcacaata 3113581 atatatatgc tcaaggcaat cagcaagccg gtaattgtcg cacgtttcac atcacgctga 3113641 gagcgcgcac ggccggacag gatcaccgcg gattcaattc cgacaaacgc ccacagtgta 3113701 gaaatcgcag cgttatgaac ctggccacca attccaatgc ttgtgccgtt ttctccttga 3113761 accgggaaat aaaaatgacc gaataatgac gtttgaaaca caaacaaacc ggcaacgata 3113821 aagaagacaa aacctaatac tttagaaagc gttgtgacaa agtttaattt acttgcgccg 3113881 ttaatgctgg caacaagaat cgcgtgcgtt ccccataaca agatcgtaca tacggcaaac 3113941 gtcagtaatt ggccgagtgt cacctcttgc ccgccgatcg aaaacatctc acgtttatca 3114001 accaagatcg ggaagaacga agtcaagtaa ccggcgagac ttgtgatgat cgccacgtta 3114061 ctgatccagc tcgccaccca gtagccccac accattgtga aaccggcagc gttgcctttt 3114121 ttcgggtcag aaaacagcgc tcttgcataa ctttgcggtc ccgctgtcag ttcaggcttg 3114181 cgaatggaca agtgtccgaa cacaagtgca atcatcagca cgccggcacc tgtcaaaagc 3114241 caggcggacg tagctccaaa cggactcgca attgaagcaa gcgagctcgg caaggagaaa 3114301 attcctgatc caaccatatt tccaacgaca aacgccgtta ataaccaaaa accccatttt 3114361 tttgtctgtt ccattccagt acctccatga ttctttgtac ggaccagacc ccgagatcat 3114421 ataaacgcaa aaaaagcctg aacaaaagtc catgcttaaa gaaacacaca cccttgatct 3114481 ccggatagcc ctccgcgaaa aagcacgcgg cagtcctgca cttattcaga tacagtccca 3114541 gcatagagaa ggatcggctt tctccacact tcggcgctga tgccttttac acatgtttaa 3114601 cagcccctgt cagcctagca tgtgtgactc atcatccgcg caacctctac ctcactgaga 3114661 aagagtgagg atttaattat tcagttactc ccagaaggtt atcaaagaaa ggatgatctg 3114721 tcaaagggaa cagatggaaa atacggatag agccaagccc tatccgcatg tggttatcga 3114781 ttatttttct ttttttgcac agcttcttga agcggatcat cttttagagc tgaaccagca 3114841 tcttcaagag ctccttggat tacgtttttt tctttttcgg aacgttttcc tttatcttta 3114901 ttaaagaaac ccattcgtat cacctctttt aaaaaatagg tacatgttta agatgccttt 3114961 ttcctgaaaa attatgcggg atatttttta tcgtccaaag tcctgttgat caaacataca 3115021 ttctcttgat atatttgtaa ttcagagatt ttttgcaaaa gataaaagga gaagcggcaa 3115081 atgacaggaa aaacacacat catgggaggc atcgcttctt gtacggcagc ggcttattat 3115141 tatggatttg atccagtgct tatggctgcg tcaggcgcgg ttggagcatt aatacccgat 3115201 atctgccaca cacaaagcaa aatcgggaga aaatttccta ttttatcgaa agtggtcagc 3115261 tccgtttttg gccatcgcac ctttacacac agcctgctgt ttatgctcat catgtttttt 3115321 atcacttcta catacattcc agataaaaac atatcagccg gcctgatgat cggaatggcg 3115381 agccacttga ttcttgacgc ttggacggtg aacggaatca aattattatt cccttccacg 3115441 atccgcgttc ggcttccatt atatatgaag acaggcagtt tttctgagca gctcgtgcta 3115501 gccggcctga cccttgcttc atgttactac ttttatatgc tgtttcatgg ccgcatgttt 3115561 taaacatgag tgctgagact tgtctgaacc ggctgttttt agtaggtttt acttaagaag 3115621 catttcatgc agatgatcaa gaaaacgtga ggagtcatat tgatgaaagg aacctttttt 3115681 cacaatcagc ggtttttatg tttttcgatc ttatttatgt ggatcaaaac gtatgtgata 3115741 tataaactcg gctttgattt gcaaatcgat actctgttgg aggagctaat gctgctggtc 3115801 aacccgctca gctttattct tcctttattc gggatcggcc tgtttctaaa agaaaacaag 3115861 cagcgggcct ttttgctgat tgccaatttg gttctgactg ttatcttgat ctctaatacg 3115921 attttttacg gcttttatat cgattttatt accatcccgg ttttatttca ggccagcaac 3115981 atgagcgata tgggcagcag tgtaaaagaa ctgttccatc ctctgtttat cgccctgttt 3116041 gtggatttgg tttttctgct gttgttcgcc agaaaaacca aacacccaca gacaaaagcc 3116101 gctccccaca cgatcaaacg gtactatgca gcttcctgcg gaatgctttt atgcacactg 3116161 gcacttgcag aagtacagca gccgaagctt ttggcacatt cttttgaccg ggaaatgcta 3116221 gtcaaaagca tcggcctgtt tcagttccat atttacgata caatttctca gactgttaat 3116281 atcagcgcga aagcttttgc cgatgaagac agtataactg ccattaaaaa ctacacagag 3116341 gctgattaca gcaagcctga tcaaagcaaa ttcggtcttg caaaggggcg caatgtcatc 3116401 tttgtaacac ttgagtcgac ccaaagcttt gttctgaatg aaaaagtaaa tggaaaagaa 3116461 attaccccat ttatgaatga tctcataaaa aaaagctatt cctttgatca tttctatcag 3116521 caaacagaac aaggcaaaac atcagattca gaatttatcg tcgctaactc actgtatccc 3116581 tcccttagcg gcgccgtctt tttcacgaaa agcgaccatc aatttcatac gatgtataaa 3116641 tcgctgaagc agcacgatta ttattcagcc gtctttcacg ctaaccataa aacattttgg 3116701 aacagagatg tcatgtacga tacatttggc attgaccgct tttttgatgt tgatgatttt 3116761 catgtcactc ccgggacatc gacaagctgg ggcttaaaag acaaagaatt tttagagcag 3116821 tccgccaaaa agctgaaaag cctaccgcag ccgttctaca gcagttttat cacgttaacg 3116881 aatcattttc cgtttgagat tgatgaaaag gatcagctga tagatgaatt cgattcaagc 3116941 agtgatctgt taaaccgcta tgtgaccacg gttcgctatg aggatgaagc attgaagcat 3117001 tttatcaaaa aactgaagga cgaaggctta tacgaaaatt cgatgatcgt atttatggga 3117061 gatcattacg gcatttctga agcccataac gaggcaatgg ctgagttttt agggaaagac 3117121 gaaatcacac cgtatgacaa cgttcagctc cagcgggtgc cgtttatcat acatatcccg 3117181 ggaatcaccg atcaacagcc ggaaaccatc cctgatgccg ggggacaggt cgacgtcagg 3117241 ccgacgctga tgcatttgct cggcgttgag acaaaaggcg atatccaatt cggcaatgat 3117301 ttgctgtcgg gcgaccgcac cccattcgcc gttctgcgaa acggcagctt tattacgaac 3117361 gattatgtat acacaaagaa cacgtgctat agccaaaaaa caggtgaagt gctggaagat 3117421 caggatgcgt gcctccctta caaggagaaa gcaaacgaag aactgtctct ctctgataaa 3117481 attttaaatg gtgacctgct caggttttcc gaatgaaaaa atccctctat caagagggat 3117541 tttttacgtt tccaatatca ccttgccagt cagcttcgtt tcatagccgt ttaaatgaga 3117601 cagattcgcc ttgtagtcct cagaattcaa aatctccttc acggctttga gcaactgctc 3117661 attttttttc aaaacaacga tatcatattg ttcgtcgatg agcgggataa aatcaacact 3117721 gcccatatgt gccgcgtgct gtgccccgat tcccgcgtca gcctgtccgc ttgaaacttg 3117781 tgaagcggca gcgtaatgat cagtcacgat atcgccatat cccactacat cagccggatt 3117841 cacaccaagc aagccaagct gttcatcaag gagcaccctt gcgccagaac ccttttccct 3117901 gttgatgatc cggatatcgg ctcttttcaa gtctttccag ccttgaatgt ttttcggatt 3117961 ccctttttgc acatacagtc ctgctttgcg gagaacgaca ttgatgagac aaaacggttc 3118021 acctgtcaaa atccgtttta cataaggcgc gttatactgg cccgtttctg catcgtacaa 3118081 atggaggctg acaatgtcac acttgccttg atacatatca atcaggctgt ttaagcttcc 3118141 tttgtattta cggagcggcg tctcctgaat ggcattctcc aaatgcttgc tgaggatatc 3118201 catcgaaatg tcctgtccgc tgatcatgac atttggtctg ccgtccggct cagcctcctg 3118261 cacctgtttc ggcgcttctt ttgcagcgat gggctgagac attctcatat tcgttttata 3118321 ttgctttaaa tcttcttcat ccacacgcat ctgccttccg acacggtaag caggcagcac 3118381 gcctttttta atcaagtcat aaacggtcag ctttgatacc ttcagcagac ctgcaacttc 3118441 ttctatcgta taggaagagg tttcattcat catcatcact ctcctatttt attatacctt 3118501 ttcgccgaat gtaaaaaaac ccacataaac caaacataat cagttataat tagttatatc 3118561 taatgataag gggtgcaatc atgtttaaga agtattctat tttcatcgca gccttaactg 3118621 cttttctgct tgtagcaggc tgttcttcaa accagtcttc aacggacagc gagaaaaaag 3118681 taacgttaac catctcagct gccgccagcg cgcaggatgc acttgaggaa atccaaaaaa 3118741 attatgaaaa agatcatcaa catataacca tccaagataa ctatggctca tccggcgcct 3118801 tgcaaaaaca gatttctcaa ggagcaggag cagatctgtt cttctcagct gctgaggata 3118861 aatttaaaaa gctggtggat gatggagata tcgcaaaaaa agacagcact gaattagtcg 3118921 gtaatgaaat tgtgctggtc gtaccgaaaa acggagattc acctgtgaca agcttcagca 3118981 atctggctga atcagaaaaa atcgctcttg gcactccgga atccgtaccg gcaggagctt 3119041 atgggaaaga atcactgaca aagctgtctt tatgggacaa agtgaaggat aaaattgtgt 3119101 atggaaaaga cgttcgccaa gttctttctt atgttgaaac cggcaatgta gacgcaggtg 3119161 ttgtttataa aacagatgcc ctagtctcga aaaaggtcaa cattgttgac gaggcaaaag 3119221 cagatacaca cagcccaatt gtctatccgt taggaatcgt aaaagataca aaacaccgta 3119281 aggaagcgaa ggaattttac gaatacctgc aatctgatga agcaatgaaa gtatttgaga 3119341 aatatggctt tactgccgag tagcataagc gcttcagaat ttttcacacc cgttgtgctt 3119401 tcctttcagg tggcggcagt tgccggaatt gttgtcatta ttctcggaac acttgctgga 3119461 gcatggatgt cacgggcatc atttttcgga aaaacggcac tcgaaacatg ttttatgctt 3119521 ccgctcgttc ttccgcctac tgttgtcggt tttattctga tcgtcatttt cggaaagcac 3119581 agcttcatcg gacaagccat cgagtggatt ttccagcagc ctgtcatttt cacctggtgg 3119641 gccgctgtga tcgcctcggc tgttgtagcc tttccgctta tgtatcaatc agccaaaacc 3119701 ggatttgctg acattgatcc cgatatacaa ggtgcggcaa tggtagacgg cgctagcaga 3119761 tggaaagtgt ttatccatat ctccgtcccg cttgcctatc cttcgttact gaccggaagc 3119821 atccttagcc ttgcgcgggc gctcggagaa tttggcgcaa cactcatgtt tgcaggaaac 3119881 atccccggtg ttacgcaaac actgccgacg gcgatatatg tcgcattgga ttccggcaac 3119941 aatacccttg cttgggcgtg ggtcgtctgt attgttgtca tttccttttt gatgctgttt 3120001 ttcattcaac agaaaaaaac gcactaaaaa aactccccat aacggggagt tttttgatta 3120061 aaacagaagc tcatcaggat ttggaccgac acgctcatct ttatttaatg cgtcaatttt 3120121 gtccatgtct tcttgagaca attcgaaatc aaaaatatca gcgttttcga tgatacggtg 3120181 ttctttaatg gattttggaa tggttacaac tccatgctgc agatcccagc gcaaaatcac 3120241 ttgagccaca gatttattgt gtttttcagc aatctgtgtc agtacttcgt tatccaaaag 3120301 ctgtccctgc atgagcggag accacgcttc cagctgaatg ccttgccctt tgcagtaatc 3120361 tcttaattct ttttgcgtca agcgagggtg aaattcaact tggttcacca tcggtttgat 3120421 ttcagcatct ttcaacagct cttctaaatg atgaacttgg aaattgctga cgccgatcgc 3120481 gcgaattttg ccgtctttgt acagcttttc aagcgcgcgc catgtatctt tatatttatc 3120541 tttgccaggc caatggatca aatataaatc taagtaatca agctgcagtc tttctaggct 3120601 tttttcaaag gcagcaagcg ttgtttcata gccttgatct tcattccaca cttttgatgt 3120661 gatgaagagc tcttctcttg ccacaccgga ttctttaatc ccgatgccaa cgccttcttc 3120721 atttttgtag atcgctgctg tatcaatact gcgatagcca tttttaattg ccgctttcac 3120781 tgattcagtc gcttcattac cattttctac tttaaaaacg cccagaccga accaaggcat 3120841 ttcaactccg ttatgtaact ttacagtatc ttttaaactt gttggcactt gaacctccac 3120901 cctttcactg aaatgtaagc gtctatatta tctcacattc ctctcagccg ataccaataa 3120961 tacgcttaag accctctttt tgcttctttt ttcacagcac aggcaaatcc aaacactatt 3121021 tttttcctat tttaacaata ttgagattac aaatacattg agcagggtat gcgtgtagtg 3121081 taaccaaatg aaaacaaagg aggaaacaac ttgaaacgta ttcgtatccc aatgacactt 3121141 gctcttggtg ccgctttgac aattgcccct ttgtcctttg cttccgctga agaaaatcct 3121201 gctccgaaga tgtcgcagac aactactgct ggaacaactg ccgctgatgt aggtttaaac 3121261 gtcaacctgg atgtacttgg aattgccaac cagatcgctg atgccatcaa atccgcacag 3121321 aatagggatg gctttgtgaa aaacctcatg gagtcttcct tctacgcgtc cggccaaaaa 3121381 tataacgtca tggtctttaa tttaagccag gaatatgaag atcatttgaa cggtgtgcaa 3121441 ttttacggct cagccgttta cgacggcatt acgtatggca tttgggtatt tgaagatgga 3121501 acctttacaa acaaaggcga tggcggctgg atcaactggg ccttcagagg ctggttcgac 3121561 cgggatggca gcactgtcgc atttcatcgc ccttaatata aaaaaagctg gcgctctaac 3121621 gccagctttt tttctgcatt tattcgccgc cttcaagcat ggcggcttcg acatcattaa 3121681 tgtattggcg aagctcatgg gagatgtccc gggaaatttc cctctcttcg aagagcgttt 3121741 gaatttcatt tctgatcgcc tgcacagcct tcagcttcac ttccagcttc tgattttcaa 3121801 aatgggcact tgattttaac tcatgatggc tgtgctccag cctgaaaatt aactgcttat 3121861 agaatgtaat gacagataaa aacacttctt tatgctcatc cgtcttatgt ttttccagat 3121921 attctatcgc tgcttttgcc gttttcactc ttgttgcccg tatcaatccc gcttcattta 3121981 aaatcgacat ctccggcttt ttatgttcac cgaagaaaat ccaatacatc agcctcttga 3122041 gccttgtttt tgataacccg actttaaacg ggttggcata caaaatttcc aactcgttaa 3122101 atcgttcttg cagcacattt gctgtttctt ccgggatgtc tccccgctcc agcattttca 3122161 tcagcgcctc ttgctcagcc ttaaccccct gcgcacggac ttttcgctcg tgcttcttaa 3122221 tgcgattaga tgatgtatac tgctgaaaac gaagattttt cattttctca ttgtattcag 3122281 ctatcaccgc aagagaggcc gttttgtttg tctcattcat gtcctcttta atcgtttgaa 3122341 gggctgtttt gatcaacttg cgtctcgccg tcagcagctt cttatttcgt tcctcgtcct 3122401 cttcttcttt ttcagtcaga attggcagca caacggtggc aatgacaagc gtgcataaaa 3122461 tgacgccggc tgctaaaaag agaatcagat ttctttccgg aaacggcgta ccgtcctcca 3122521 ggaaatacgg aatggaaaaa gaacctgcaa gcgttactgc tccacgcaca ccggaaatcg 3122581 aaattaacag cgtcgaacga agacccggtt tatagatgtt ctgatcttta ttaaagaacc 3122641 atttgccgtt ccagaagaac agcacccaca ggaatctaag gagcattaat gtaaatgtga 3122701 tgactaggat atagccgatc accttcatgt tgctgatggc agtgtcgtta aagataacag 3122761 aaataacatc agggatttgc gtgccgagaa taacgaagac caggccgttc aaaataaata 3122821 aaataatgtt ccacgtactt gaggagacga tttgcagctt gatcatcgtt gattccagac 3122881 gatcctgttc aaccgcatgg gtaataccgc cagctacaac agctaaaatg cccgaaacgc 3122941 cgatttcttc agctgccaaa taaatcacaa acggcgtcag aatttgaatc agcatatgca 3123001 tcgtgacatc ctgcatgcca aggcggcgca gaaataggcg aaaacgaata atcaaaaatg 3123061 aaatgacaac cccgcacagc aagcctccga gagaaataaa gacaaagctg acagccgctt 3123121 gtgctaatga aaatgcacca gtcactgccg ctgcaatcgc aaacttaaag gccaccagac 3123181 ctgatgcatc attcatcagc ccctcacctt ccagcaggcg aagaatccct tttggcattt 3123241 tcactcttcc tgataatgcg ctgacagcga cgacatcagt cggtgaaaga atggccgcaa 3123301 gtccaaaggc cgctgccagc ggaatagcag gaatcatcca gtgaatcgtg tagccgccta 3123361 caatcacagt cgcaaataca aggccgagtg caagcaataa aatcggagcc cttaaattcc 3123421 aaagctctgc ccgcggtgtc ctctttccat cattaaatag cagaggcgcg ataaaaagaa 3123481 caaaaaacaa ttcggtgttt aattcaaaat gaagtccctg tggaaatgag gcggcaagaa 3123541 tcccaagagc cacttgaatc agcggcaccg gaataaacgg aataaaccgg ttcacgatat 3123601 tagaaatcgc aataatcgtt aataatacga gcacaactaa aaatatgtcc aaatgcatga 3123661 cctccttcgt ctgttgtgtg tcggcatgat gagccaaaaa atctgtttgt ctaaaagccc 3123721 ttgagctagg gtggccttgc atccgctatg tggtttcgca ggagttctct ccacacttgt 3123781 cttcttttat agtacccttt ttagggtatt ttttctcatg atatgctcac agtgaacttt 3123841 tttgcagaag agcaaattat agaaaaaaga gacaggaagc tactccctgt ctctcgtctt 3123901 tctttctcaa tcatgaaaat tcgtaccgtc agttgttgct ttaataatgc ccgcgcgaat 3123961 gacaaagtca ccgaaatgct cgccttcctc gcgttctttc gcatagcggg aaagaaggat 3124021 gcgcagctcg cttaaaatgt ctgcttcacc gatgttttca cggtacattt tgcttaaacg 3124081 gcttccgtca aacgcagcgc caagatacat attatatttg cccggcgcct ttccgataaa 3124141 tccgatctca ccgagtgcat gacgtgcaca gccgttcggg catcctgtca tgcgaatggt 3124201 gatttcctga tcacgaaggc cgttttcgtc aataatctct tcaatcttat ctaacagggt 3124261 cggcaaataa cgttctgctt cagccattgc caatccgcag gtcggaagag cgacgcacgc 3124321 catcgagctg cggcgaagcg ctgaatagtg cttgccgtca gttagtccgt actgttcaat 3124381 taaagcactg atttcttctt ttttatcgct tgaaacgttc gcaatcatta agttctgatt 3124441 ggctgtcagc cggaactcac ctgtatgaac tttggcgatt tcccgcaagc cagtcatcag 3124501 cttataatca tcgtaatccg ttatacggcc gccttcgaca aacagcgtga aatgccattt 3124561 atcctcgatg ccttccaccc agccatagcg gtcgccgtta tgatcgaaat gatacggctt 3124621 cgcttcttcc aggctccagc cgagacggtt ttccaattct tcttttacgt tttctaaacc 3124681 gaggcggtca actgtgtatt tgaaccgcgc atttttacgg acagaacggt tgccgtaatc 3124741 acgctgaatc gtaatcgttt tttcagcaac gtcatacatt tgctcaggcc ggcagaaacc 3124801 gatcaccttg gctaattgcg gatatgtcgc agtatcgcca tgcgtcattc ccataccgcc 3124861 gccgattgcc acgttaaaac cgatcagctt gccatcctcg acaatcgcaa tgaatccgag 3124921 atcttgtgaa aagacgtcaa tatcattaga cggcggaacg gcaataccga ttttaaactt 3124981 ccgcggcaga tagagcggtc cgtacattgg ctcgacttct tcctccggcg tgccggcaac 3125041 tctttcctca tcaagccaaa tttcatgata tgctctcgtc cgcggcagca gatcatcact 3125101 taatttttta gaccactcgt atacctctga gtggatttca gattgataag ggtttgatgc 3125161 acacatgacg ttacggttta cgtctccgca ggctgcgatc gtatccaaaa gtgctgagtg 3125221 gatcgtctga atggttttct tcatgttcca tttcagaatt ccgtgcattt ggaatgtttc 3125281 acgtgtcgtc aattttaatg tgccgttccc gtatttctgg gacaggtcat ccatgacaag 3125341 ccattgttca ggcgtcgaga cgccccctgg catacgcacg cgcagcatga actgatatgc 3125401 gggctcaagc ttctgctttt ggcgttcatt tcggaggtcg cggtcatcct gcaaataact 3125461 gccgtggtgt ttcatcaggc ggttatcatc atccggaatt cccgcactga ttcgatcgag 3125521 catcacttct ttcagcgtgc cgcgcaaata atcactttct tttttaatgc gttcaacatc 3125581 acttggagag ccgtccggtg cttttagaat tttggtcacc atgttgaaaa actcctttca 3125641 agtcaaatca atatacatca cgctgatagc gtttttgctg ctgcatatcg gcaagataag 3125701 cctccgcctc ttcgcggctc atattgcctt ctttttcgat aatttcaagc aatgtgttat 3125761 ggacgtcatg cgccatgtgc ttttcatctc cgcaaatgta aacagccgct ccttcttgaa 3125821 gccattcaaa caattctgcg ctatgttcaa gcatgcggtg ctgcacatat actttttctt 3125881 ccgtatcacg tgagaacgcc acatccattt ttgtcagcac accgtctttg agccaattct 3125941 gccactctgt ctggtaaagg aaatccgtga caaagtgctg atcgccaaag aacatccatg 3126001 cctttccttc cgctcccgtc tcctcacgct cctgcataaa cgaacggaaa ggtgcgacgc 3126061 ctgtcccagg gcccaccatg ataatcggtg tttcagggtc tttcggaagc ttaaagtttt 3126121 gattgtgctg tacataaacc ggcagtgtgt ctcccggctg cagtcgttcc gcgcacaaaa 3126181 tcgagcagac gccttttcgt tcacggccgt gcgcatcgta gcggactgcg ccgattgtta 3126241 agtgcacttc atccggattt gcggataaac tgcttgcaat cgaataaagg cgggcaggca 3126301 tttttcgcaa aatcgagaca aactcctgcg cagatacact aaatgggcca tagtcacgga 3126361 cgagatcaag caaatcgcgc ccttcaatat aggcttttac attctcctca tttcccgggg 3126421 ctaaaagctc tctaagctca tcgttccctg tcagctgggc tgcctgttca agaagcggtt 3126481 ttgtgagaac ggtaatctca tagtgagaaa tcagcgcttc tttcagcggt cggacatcac 3126541 cttgcttatt aagcgtcaca atttcttccg ggtcccaatt catttcctta aggagcagct 3126601 cgacaagttc cggatcgttt tccggataga cgccgaggct gtcaccaggc tcgtaagtca 3126661 ggccagatcc ttcaagagac agctccacat ggcgtgtttc tttatttgat cctctgccgt 3126721 ttaaatttaa attttctaac acttcagccc gaaacgggtt tgttctggaa tacgaagact 3126781 caccggtttg tgacgcagcc gccggcgcag gcgcggcgct tccgccccca gcttcattta 3126841 atcctttcaa tacaccctca agccattcgg ctgccggttc atcatagtca agatcgcaat 3126901 caacgcgcgg agaaatccgt tttccgccga gttcttctaa gcgttgatca aattctttcc 3126961 ctgtctggca gaaaaattcg tacgaactgt caccaagcgc caaaacggaa aagcgcaggt 3127021 cttcaagctt aggcgcccgt cttccgtgca gaaattcatg aaacgacagc gcgttatcag 3127081 gcggctcgcc ttctccatgc gtactgacga cgattaaaag attggttacc ttcttcagct 3127141 gattcggctt aaaatcgctc atggatgaga cggtcacttg aaaaccgctc tgttcaagct 3127201 gcttgccggc attttctgca agcccctgtg cgtttcccgt ctgtgaacca taaagaacgg 3127261 tcacttcttt tgaaacggcc ggtgccggtg cttccgctga cacagctgcc gccggcgtac 3127321 ccgcagcttc ttgggcggaa acagattgag cggataaata tccgctcagc cagattttct 3127381 gggattcggt caaggtcggc agaaggcggt taaggagctc tgcctgctcc tgattaaacg 3127441 gactgttcat tacctgaagt tgcaacgtat ccacctcaca aagttataaa ctgatcgaaa 3127501 attgcatcta attgaacttt accggaatac taggcttaag taaaatatat ttacatgatg 3127561 ataactatta agaatcctaa tgataaaacg gctatgcttc atgtaaatag aaaaaagaga 3127621 aggactccct tctcttcatt cagcaatctg atataagtga ggcggcacag cggttacaaa 3127681 cggactggct tcacctgtat aaaataccgc cagcatgtgc atcgcacggg tgcacgcagt 3127741 atataaaagc ctgcggtcgt gctctgtatg atagtgttct tcagatgcat catagacaag 3127801 cactgcgtca aattcaattc ccttcgctaa atacaccgga atcacgcaaa cacccttttg 3127861 aaatggttga ttttctttat gaatcaggcg aacatctgta tattcactca tgtgggcgtg 3127921 cgcctgtatg cattgatgcg cagtcttgca gatgacggct attgtttcgt gccctttttt 3127981 cttgagccgg ccaatttctt gcgcgagctt ttggcaaagg ctctcatgtc cttcagtttt 3128041 gacaacgagc ggcatttccc cgcttctatt aaacggctca atatccgctc catcttgaag 3128101 catcgctttg gtaaactcga caatctgcct tgttgatctg tatgttctct ttaaacgaac 3128161 atactcagca ggctcatcct caaagcacgc atccatacgc tgatccccgt ttatggtatg 3128221 cgcgtagatg gactgattga tatcaccgag cactgtcatg ctggcagccg gaaaaatgct 3128281 tctcatgtaa gccatctgaa acggtgaata gtcctgggct tcgtcaataa atagatgttt 3128341 gattttcgta tttttctttc tgccctcaat cagatcctgc atataaagaa acggtgccgc 3128401 gtcctcatag agcaatttat tatccgtaaa tgccgaacgg gtcagctcac ctatcgcatc 3128461 catcttctca tgttgaaatt ttcctcccca gccagaaaac aattgcaaat aaagttgtgt 3128521 aacatcaaga aatgcaagga gcctgactgc ctgtttgagc ggtttgaaag cttttttcac 3128581 aatgatggcg gcaagcagct gctgctctct ttgataatcg ttaaacgtac tctcgctgaa 3128641 ccgtttcctt tcctgcagtt ttttgtacac gtccaagtag tcctctttgt caagcagctc 3128701 agcttcatga acaacccaat cctttcgccg ttcctttttc tcaagcttgt taagctcact 3128761 cagcagccac ttcgcggttt gctccatccg attcggaatg gagtgatttt gatccaatga 3128821 gtaaaaatag gattgaattt gctcctttgt gatcagcttt tgtccgcgga atataatatt 3128881 tttaaaaatc atcccttcag aggaaagccg tgtgacgtat tcattaatga attgctgaaa 3128941 ggataaaccc gccttccatg tgattcctgc aagccttgtt ggaaaatcgc ctccctttgt 3129001 ttcggtcagg caatattcga gctgatcaaa ggggctttca catttgaact tgcggccaag 3129061 acgatgctcg atatattcct gaaacgtcgc ctgctccata ttctcttctc ctaactccgg 3129121 caaaacagag gagacatagc tgttaaataa gaagttgggt gaaaacaaaa cgatttgtcc 3129181 ggcatcaatg acaccgcggt gcctgtataa caaataagcg acacgctgaa gcgcagccga 3129241 tgttttcccg ctgccagccg ctccctgcac gatcaggatc ttgctttttt cattacggat 3129301 aatctgattt tgttctttct gaatcgtaga cacgatgttt ttcatttggg tatcagagtg 3129361 atggcttaat acctcttgca gcatttcatc gccaatcgtc atatcggtat taaacatcgc 3129421 cttgagagtg ccgtttttga tcataaactg gcgtttcagc accatttccc cttctatcgt 3129481 ttcaccgggc acctcgtact ccgcttttcc tggggaataa ttgtagtaca aacttgatat 3129541 cggcgccctc cagtcataga tcagaaagtg ttcctccttc tcatccaaac aggaagctaa 3129601 accgatataa attcgctctg cctgctcctc gccgttttca ataaaatcaa tccggccgaa 3129661 ataaggcgat tttttcaatt gatgaattcg tttgagctgc tgatccatgc gccgatgatt 3129721 gtgttcccga tcagacagca gctctgcctg ctgcttaatg ctagccatcg tttcaatcgc 3129781 ttcatgggca tcatcaaaat taaccttaac atcctcccaa aagctttttc ttaatccgat 3129841 gatatcatgc ttcaacccgc ccgcagacgt ttccagaaac cgctcttttt tttcgagctc 3129901 cttcagcacc tcatctattc tcgactgctc ttccttccat tccttatcct gctgattcat 3129961 gaacggcacc tccagaaaat agttgacaaa catagatgaa atactgtaaa atataattgg 3130021 atacatatat taaatatatg atgcaaactg gcaaatacaa tttataatag cacattcacc 3130081 caataccaat caaggtttgg gttatttata ttatgcagaa aaaaaccgat ttcacttcga 3130141 aatcggtttt tttgctatta attatctaag cgaaaagaac ggtttggcag cttccaatta 3130201 aacatatagg aacaaacccg gcaaacaacg agcacgaaaa acagaacgta taagccgaac 3130261 gagttcccca gccagcccaa gccgacgatt aaaccgccga gcgccgccca taccgcatag 3130321 atttccgctt tcagcacaag cggtttgcgc ccggcaagaa ggtcgcggat gatcccgccc 3130381 ccgcttcccg tcagcaccgc agccacgatc acggcactaa gcggatggcc cattttgacg 3130441 gcatacagtg cgccttggat agcaaaggca gcgaggccga tcgcatctga taaattgccc 3130501 cacttattcc aatgcttcag cagcagcttc ggaaacagaa acacaattgt aatagataaa 3130561 agcgcgattt gaaagtacgc tccctgctcc catagcgctg acaccggaac accgatcagc 3130621 aaattgcgga tcgctcctcc tccaaaagct gtgacaatcc ctaatatata aactcctaaa 3130681 atatcatatt cctcttccat cgcaacaatt gcgccgctga ctgcaaacgc aatgatgcca 3130741 atcacactaa gcagctccca agccattctg atgactccct tttatgtttg ttaaattttc 3130801 tgacgacctc tagattttat aatcgctcca gcgtaaaatc aataacattt tcatgagaaa 3130861 aaaagataaa tttagaggga atacggctat tgctgatgga catgagtttg cgaaattaaa 3130921 aaagcgcccg gcatacgcgg gcgctttttt tgttattcag atttttcgcc tttcagcagg 3130981 cacataaaaa tgataatcag gataaaagca atcagggcca ggaatggaat cgtaataaaa 3131041 ccaaaccagt taatatattg gcccgagcac ggcacgccgc tgacacatgg cttaatgccg 3131101 ctaaagccgg gcactttttg ctctaagtaa tgcatgatcg aaatgaatgc cccaataatc 3131161 gccatcggga gcacatattt tttcactcgt gtgtcccctt gaaaggtggc gatgcctaaa 3131221 atcaggacga gcggatacat gaggatacgc tggtaccagc acagttcaca tggaataaac 3131281 tttctgattt cactgaaata caggctgccc agcatagcga taagagccac aacccaggaa 3131341 gcatataaaa atacgattct atttttcata ttgttacttc cctttcagct ctttttctat 3131401 tgtctctttg atttcatcat aatccgcaaa atttttgatc actttatcat tgacgtaaat 3131461 cgtcggtgtt gcctgtatgt tcattttttg attaaggtca gaatcctttt ccacttgaga 3131521 agcgaatgtt tccttatcaa gattttcctt gagcgtctca ggttttatct ttgtggtgct 3131581 ttttgcaaga tcaccaagga ggcctggggt tacccattcc tgttccgtat ccggctgttt 3131641 ttcgaacagc ttttcatgga aatcccagaa agagtcaggg tcttccttcc atacttcttc 3131701 agatgcaaga gccgctaacc ttgaaccttt tccatggaac atgacgttca cgaaagaaaa 3131761 tttcacatcg cccttatcaa taaagtcttt ttgtattttt ggaaagatgt cactgttaaa 3131821 caccttgcaa gacggacatt tgtaatctcc gaattctact acagttaccg gtgcatcgtc 3131881 cttgccaagc acaggctgcc ctttgataga cggctgtccg gacaccgcat cattgccttg 3131941 ttccgttttg ttattaatga tgacaatggc tgctagcaat acaacaacca caaccgtaag 3132001 gatgaccgcg aatttcgcag aagactgctg tttctttttc actccgacac ctcatcgttt 3132061 taaaattaaa aaagaagcgg atcgcaattg acccacttct ttattttaac aagacaagcg 3132121 ctgataagaa aaccccgaaa aaatgaattc tctccgacaa tttatttgtt tttgagacgc 3132181 atgacgcgca tggcgttcgc cacagcaagc agtgtaacgc cgacatctga gaaaaccgct 3132241 tcccacatgg tcgcaattcc aaatgcacca agaatgagaa agatcgcttt cacacctaaa 3132301 gcaaagccga tgttttgcca cacgattcgc cgtgtccgtt tcgcaatccg aatcgcttct 3132361 gctatttttg acggctgatc tgtcatcagc acgatgtctg cggcttctac cgcggcgtct 3132421 gagccaaggc ctcccatcgc aacccctata tctgcgcgtg caagcaccgg cgtatcattg 3132481 atgccgtcac cgacaaaaat gagtttttca ctaggcaaaa gcttagcttc taatgcttcg 3132541 acctgcgcga ctttatcttg cggcagcagc tctgcatata cctcaccaat cccaagctgt 3132601 tttccgacgg cttctcccgt ttgtttcgaa tcacccgtca gcatagctgt ctgtttgatc 3132661 ccaagcgact tcagatcagc aaccgcctgt gctgcgtctt cctttatctc atccgctatg 3132721 atgattgctc cggcatagcg ttgatctaca gcaacgtgta cgattgttcc agcattttca 3132781 tccgggacat cctcaatttg ttctctttcc atgagctttt tattcccagc aaggatctca 3132841 gttccattta cctttgcaaa aatgccgtga ccggagattt cttcgtatga ctcaatctca 3132901 tcggaggaaa gcattttccc gtaagcttta cgcacagatt cagcaatcgg atgctgtgaa 3132961 tgaagctcag cgtatgccgc cgcttcaagt aatctatcct ttgtaaaacc ttccgcgggt 3133021 ttgatttctg tcacttcaaa gctgcctttt gttagtgttc ccgttttatc aaacaccgcg 3133081 tatttgactt gattcaaagc ttctaaataa ttgcttccct ttacaagcac tccggccttt 3133141 gaggccgctc cgattccacc gaagaaaccg agcggaatag agacaacaag cgcacaagga 3133201 caagaaatca ctaaaaagat aagcgcgcgg tacacccaat cggaaagcgc ggcgccagaa 3133261 agaacaagcg gcggaacaaa ggccagcaat accgcaatga tcaccacagc aggtgtataa 3133321 tacttggcaa acttcgtgat aaagttttct gtccgggctt tacggctgct cgcattctga 3133381 accaagtcta atatttttga tactgctgat tcctgatagc cctttgtgac ttcaatatgc 3133441 agaacgccgt tttgattgat aaagcctgac attacatctt gtccttccgc agcttttctc 3133501 ggaacggact cacctgttaa agcagatgta tcaaccatcg ctgacccttg cacgacctta 3133561 ccgtccaggg gtatgctttc tcccggatta accacaatga tgtctcctgt ctgaacgtcc 3133621 tccgacgaaa cctgttcgat gccgttcttt gttttgagat tggcgtaatc aggccgtatg 3133681 tccattaacg cactaattga ttttctggaa cggctgaccg cggctccttg aaaaagctca 3133741 ccgatttgat aaaacagcat aacggcgacc ccctcagggt attgctgaat cagaaaagcg 3133801 ccgattgtgg caagagccat taagaaatgc tcatcaaaca cctgaccgcg gatgatgttt 3133861 ttgactgcgc ggattataat gtcaccgccg ataatcaaat aagcaccgag gaaaaggaaa 3133921 aattcaatgg ttcccgactg aaccaaatat gccgctgcgc cgagaatgac agccgccgcc 3133981 attctgatca gcatattgac cattcgatta cgatagccat catcagctga tttctttata 3134041 tgcttttggc gaaccgttac atgcggatca attgatttca cttttttctc tactttattc 3134101 gtgacccatt gctcttcttt cccatcggct gagacagtta aggtgcttgc cgcaaaattt 3134161 accgcgcatc cgttaatgcc ttttatgcct ttgactccat tttcgatttt tcgggcacaa 3134221 ttgctgcaat ccaaaccgtc cagaacatat tcctgtttca ctagtctcac cttaccttcc 3134281 gatttagggt tccctcttca aagcgtatca atgagtattg tatttatttt atatatatga 3134341 gcatatactc atatataagt tacacctatt atatgttgtt ttccaagaaa gtgtcaatga 3134401 aaaacaaaaa ccggcatata gccggttttt cattttactt tttgcagacg aagagcattc 3134461 agaacaacgg aaacggagct gaatgccatt gctgctcctg ctatccacgg tgctaaaaat 3134521 ccaagtgctg cgattgggat gccgaggctg ttatagccaa gcgcccagaa taagttttgt 3134581 ttaatgtttt tcattgtcaa tctgctcatg cggattgcgt cggcaatgct gttcagatcg 3134641 ccgcgaataa gtgtaatgtc tgctgtttcc atggcaatgt ccgtgccagt tccaatcgcc 3134701 atgccgatgt cagctgtggc aagcgccggc gcatcgttaa ttccgtcgcc taccattgct 3134761 gtctggcggc cttctttttg caagcgggcg atttccgccg ccttttgttc aggaagaact 3134821 tccgcaatga tattcgcaat tcccgcttcc ttcgcgatgg cttctgcggt tctgcgattg 3134881 tctcctgtca tcatgatgac atcaagaccc aactctttca gacgggcaac agccttccgc 3134941 gacgtatcct taatcgtatc tgcaactgct actagccccg ctgcttctcc atcaatggat 3135001 acaagcataa ctgttttccc ttcggcctct agctcttcca tttgggcgag aagagcccca 3135061 tgctcaacct gttcgctctc cattaatttt cttgtgccga cgagaatgct ttttcctccg 3135121 gcttcagcca aaatgcctgc gccgactttt gcttcaaagc gggtaagttt cggtatctca 3135181 agccctttat ctttcacgcc agcaataatc gcttcgccaa gcggatgctc tgatcccgtt 3135241 tccgctgccg ctgcaaattg aagcaaatct ttttcttcaa aacggccgaa tggaatggca 3135301 tccgtcagac gcggcttccc gtttgtcacg gttccggttt tatcaagaac aattgtatcg 3135361 agacgatgtg ttttttctaa atgctcgccg cctttaaata aaatcccgaa ttcagcagcg 3135421 cgtccagatc cagccattat gctcgtcgga gtggcaagac cgagggcgca aggacaggca 3135481 atgacaagaa ccgcaatgaa cttgctgatc gcttcggcaa aatcgccagg agccgcccaa 3135541 agataccaaa tgagaaaagt gagaaccgca atccccaata caatgggtac aaaaatgcct 3135601 gaaatctggt cagcgagacg ctggatcggc gcttttgacc cttgtgcttc ctcaacaatt 3135661 ttgatgatat gagaaagcgc agtatccttt ccgacgttga cagctttaat tttcagaaag 3135721 ccgtttgcgt taacggttga acctgtcacg ctgtcaccag gatttttgtc aacaggaaga 3135781 ctttctcctg taatcatcga ttcgtcaacc gctgaacggc cttcaaccac ttctccgtcg 3135841 acaggaattc gttcgccagg tttgacgtaa acaatgtcat taacaagcac ttcgtcgatc 3135901 gggatgattt gctcctgtcc gtctcttaca acagtagctg ttttcgcttg aagcttcatc 3135961 agctttttaa tcgcatccga ggaacggcct tttgcttttg tttcaaacaa cttgcctaat 3136021 aaaatcagcg tcagcaaaat cgcgcttgtt tcataataaa ggccgtctgt atgcccgtga 3136081 gagccaatgc tttgaaaagt tagataaaga ctataagcgt aagcagccgt cgtaccgagg 3136141 gcgaccaata catccatatt ggcgctttta tttctaagcg ccttatacgc acccacataa 3136201 aacggccagc cgatcagaaa ctggactggt gtcgccagcg caaactgcat ccacggattg 3136261 agaaatatat ccggtaccca aatgaatgat gtaaatgtaa aatggctcac catcgcccaa 3136321 agcaatggaa atgacaggac agctgaaaaa atcagtctcg ccgtttgctt ccgttcttct 3136381 ttctttttag cagcagcctc actgtcctgt tcacccttca actttagctt atatccaagc 3136441 ttatctaccg cttctttcaa atcgctgaca gacgcttctt ttggattgta ttcgaccgta 3136501 actgtttcta aagcgaagtt tactggtgca tttgcgacgc cttctatttt gttaagccgt 3136561 ttttcaatcc gattggcgca agccgcacag gtcatgccct caatatcgaa ttcagctttt 3136621 tctgtaacga cgtgatagcc cagcttctct attttttcct gaatcgctgc agtccctgtt 3136681 tcagcaggat cgtagattac atttgatgtt tccgttgcca gattaacatt tgcatccgtg 3136741 acaccgggca tccgcttcag gcctttttca attctggcag cacatgccgc acaggtcata 3136801 ccagagacct gcatcgcgat ttccttttgt tcactcaaca tactcactcc tttatataca 3136861 cctggggggt atataaaaat gaaagaaata tcgcgcctcc ctaaaggcgc gataccttga 3136921 atcacttggc tacgtcatag ccctgatctt ctatcgcatc cgcaatatct ttgactgata 3136981 ctttgtcagc atcaaacgaa acatcgactt tacccgcttc cagattgaca tgaacggcac 3137041 tgacgccgtc cagttctcct acgcttgttt ctactgcttt gacgcagtgc tgacaagaca 3137101 ttccttcaac ttgcaatgtt ttttgttcca tatcaattcc tcctgtttat tctttctatt 3137161 ttcatcctac catacccccg tagggtatta caataaaaaa cgctttatga ttttgtgaac 3137221 tttttaaata cgtccaaaag ctcagaaatg gcctgttccc cgtctccgct tttgatggca 3137281 tctgctacac aatgatgggc atgatcctca agcaaatgaa gcgccacatt tttcattgcc 3137341 gcctgaacag ctgaaatttg cacaagaata tctacacaat atctgtcgtt ttccaccatg 3137401 ttttgaatgc ctctgacctg gccctcaatc cgcttaagcc ggtttgtaat ctgatccttt 3137461 tctttcgagc ttttatggtt taatgtttta tgttcgttat gcttttccat gcgtacacct 3137521 ctgtttaatg atattaattc ccattatact gattgtccaa acggttgtct aagcatgccg 3137581 acgcaaaaaa tgaatcagtt aggttttacc atttgatcag gagggtatat acttctgttg 3137641 ataacgcttt taaaggggag aagaaaagtg gatacgatca aggttggaat attaggatac 3137701 ggattgtccg gttctgtttt tcacgggccg ctgctggatg ttctggatga atatcaaatc 3137761 agcaaaatca tgacatcacg gacagaagaa gtgaaacggg attttccaga tgctgaggtt 3137821 gtacatgagc ttgaagaaat cacaaatgac cctgccattg agcttgtcat tgtcaccacc 3137881 ccgagcggcc ttcattacga gcatactatg gcatgcatac aggccggaaa acatgttgtg 3137941 atggaaaaac caatgacagc aacggccgaa gagggggaaa cattaaaaag ggctgccgat 3138001 gaaaaaggcg tattattaag cgtatatcat aaccgacgct gggataacga ttttttaacg 3138061 attaaaaagc tgatctctga gggatccctt gaagatatca atacatatca agtttcctat 3138121 aaccgctaca gacctgaagt tcaagcgcgg tggcgggaaa aagaaggcac tgccactggt 3138181 acgctgtatg atctcggctc ccacatcata gaccaaaccc tgcatttgtt tgggatgcct 3138241 aaagccgtga ctgcaaacgt gatggcccag cgggaaaatg ccgaaacggt tgactatttt 3138301 catttaaccc tggattatgg caagcttcaa gccattctat acggaggatc aatcgttccg 3138361 gcaaacggac ctcgttatca aatccatgga aaagattcta gctttatcaa atatggaatt 3138421 gacggacagg aagacgcact cagagcggga agaaaaccag aggatgacag ctggggtgcg 3138481 gatgttccgg agttttacgg aaagcttaca accattcgtg gctccgacaa aaaaacagaa 3138541 acgattccat cagtaaatgg ctcctacctt acttattacc gtaaaatagc ggaaagcata 3138601 cgagaaggtg ctgcgctgcc agtcactgct gaggaaggta ttaatgtcat ccgcatcatt 3138661 gaagccgcga tggaaagcag taaagagaaa cgaaccatta tgctggagca ctaaaacaaa 3138721 agcctcccca aataagggga ggctttttca ttagaatgtt tttcctgctt ctttcgcacg 3138781 cgcaatcgcg tcttctttga tttgctgtgc tttatcaggc tccgcattat gtccctctac 3138841 gaaaatgcca tcgaatgatg gtacgccgaa gaagttcatc atgatgccga tgtagcggtg 3138901 ccccatttcc atctcagccg cagggccttc tgaatagtag ccgccgcgcg cttggatatg 3138961 aattgctttt ttatcagtta acaagccgac aggaccttgt tctgtgtatt tgaatgattt 3139021 tcctgcaaca gcaacagaat cgagatacgc tttcatcact ggcgggaatg agaagttcca 3139081 taaaggagta acaaatacgt acttatcagc tgatgcaaat tgatcgctaa gctctcccaa 3139141 acggcctact ttcgcttttt cgctttcaga aagctcttca aagcctgtac ctgactgaag 3139201 ctttccccat ccgctaaata catctgcgtc aatgtgcgga atgttttctt tgtacaaatc 3139261 gatatgtaca acttcatcat ttggattcgc ttctttgtaa gattcgataa atgctttacc 3139321 tgttgccata ctgtacgaag ttgcttcgtc atgtggatga gcagtgatat ataatacttt 3139381 tgccattttt accagccctt tcgtttttaa aaatcacaca tcaattatta tcatacagat 3139441 gcataatgat tattctgtct ctcttagact ttattataga gacaaagaaa tttactttca 3139501 agtaaaacat ctcgaattaa agattattta actttcccaa acagcttact tttcaaaagc 3139561 tgttctcaag ccggaataca gcgcggacaa ttctttactg atccgaggat aatgagggac 3139621 atgcggcact tgaatatccg caggcatcct tttcatgata aaggattgct cagcctgttc 3139681 aaaaaacgcc cgcagctggt tgatctcttc atcagaaaac ggagcagacg gacggcggtg 3139741 agcttgcgcc gagagcaaat agtaccctaa gtgctgagca ccggaaatgg caggccagag 3139801 cgcatccgca ttcgcgtgag gaaactcgcc aagcgccttg tcatacgcat cccgaagcct 3139861 gacaagactc acccttaact tgtgttcgtc ggcaatttgc ccggttaaca gtttctccat 3139921 aaactgccct tccagccgga tgacattccg cacaagttct ggcagccgct tggttgaaaa 3139981 ccgccgccac aaaagcattg ttcccaacag cccgatcacg ctgccgacag ctacatcagt 3140041 cagcctcgct atcataaaat aaccggcgcc cgccccgcca tgcatacttt ctgtgataac 3140101 aagcgcattt gcggttaaaa agggaacagc cagcgcataa ttgcggacga tcagcatctc 3140161 aagaagacat tgcagcgctg caatacaaaa cgcaatataa acaccgcccg gcttaaaaaa 3140221 caggattgcg cctgccagta taacaccgat caccgttccg gccgaacgct gaatagccct 3140281 gtgaagcgta aaaacaacag tagtgccaag catgaccgct gctgccgaaa gcggaatcca 3140341 ataggagcgt gcaaagccga atgcgagggc aaacatatcg gcggcaaaca gaacaattcc 3140401 gtactttaac gctctaatca aaactggaga cttccagtca aaggcatttc tcaaaaagta 3140461 aaaagaggat ggcaggcggc ttggttcccc gtcaagctgc ttatcaaaac gtcctgaagc 3140521 gatatacaaa acctcattga tttcttcaaa cagcttccgc ctaggctcag attcattttc 3140581 attaatctga aacgtattga aaacccgtgc attcgcaagc atatctccgg tttggcgaag 3140641 tgccttttca atctgcgcgg tctctctgtc cggcgtttca gctgaaaaat gaataatggc 3140701 aataaatatg tcgtcagctt tctcaaggag gcgaaaaaat cgttcatcat gccgcgattt 3140761 tttccgtctg ttccctttcc caagaaccgt ttggcgggct gttctaagca tgagcaccgt 3140821 ctgatgctgt gcgttatgaa aacctggcgt tccgacggct gaaagacatg cagccagctg 3140881 atgatatgtt ttttgcagca ccgctccctc cggtccatgt ttgttccata accagccgat 3140941 taaagcgata cccatggcga aaatgccgcc gagaaacgtc agtcccgctc tgaacagcgc 3141001 ttgtgaagga tcggccggca gcccggaact gactaaaaag gcaaggacaa aaaacatcgg 3141061 cgcagggcct tgaatgccga gcgcgctaaa aataaacatc gccgctgcac cgatcagccc 3141121 caaaacagcc gccatcatcc aaagcatccc ggacaaaagc gtccctaaac caaatgagag 3141181 ggcgatccca atagaaacca agagcagctt caaggcgcgc tttttgtacg attcaccgcc 3141241 cgcatataaa taaacaaagc ctccgatact tgcaattaat ccgtaatccg tgtgacctgc 3141301 caatgcaccg accagcacag gaaaccctga agcgaaacct gatccgatag cctttttcca 3141361 aggaaatgga tttgcatgaa tgcgaaaggc atccttcacg ataggcatga ttctttgatt 3141421 gttcgcagca gttttgttca tttgacaaaa tccttttcaa tgaatgtgta gaacttttcc 3141481 agtttcttcg ctttagtatg cccaaaaacg cggttagctt ctcaattggt gcgcacgata 3141541 aaaaaacaga gacttatacc gtctctgctt cattacatca gtttattata aaagcggcac 3141601 ctgtcaggac tgttttgtcc ttctgccttc cttcaagagc aggtgaataa aaaataaagg 3141661 ataaatcaat agatacccat taaacagcca ccacacaaga tcaaagtcac tgctgaatgt 3141721 ccagaatgat agcgcctgca gacctgaaca acaggtcagc acaagagaaa tcagcgccat 3141781 cagcttccag tcagcacgat tcacccgctg taggtacaag ctgtacaacc ctgtgacaga 3141841 aatcaggata tccagcggaa aaaaagacca gttccaagcg atcataaacg gatggtcatg 3141901 atgtttaaaa gcccagcttt ccggtatgag cgaaaatccg gctgacagcc agtacaagat 3141961 aaaaccgata tcagtcacga gaaaaaacag cttcatatat ctcatttgta ctgcccgctt 3142021 ttatgtaccg gctcagacac cgcaacatgc tcgatcaggt ttaaagacac aacaccggca 3142081 ataatcaatc caattgaaat gactttcatg acactcacat gttcttgaaa aaacaaaaaa 3142141 ccaacgactg taatcaagac aattcccatc cctgaccata cagcataagc aactgataca 3142201 tcaatggatt taagcgtaag cgtcagaaag aaaagactcc ctccataaaa gaaaatcaac 3142261 agcaaactgg gaataagctt tgtaaaacca gacgatagct tcatgctgac agttcccgca 3142321 acctcaaaca aaatcgccaa gcatagaaac acccaattca tgtggcatca gcctcctcat 3142381 cagctgttat accgttaaac aaaacatcta caattgattc aagtacctct cctgtcgtga 3142441 actgatgttt cagcggatat tcagggtcat acacttgatt gatgctccct atatacatgt 3142501 gaacaaacag gtccggattg atgtttctga ttctcttttg ctgtttgcac tcatttaata 3142561 atgctaggac aatcgcccat tcttccttaa taaacgcgtc taatgtaagc cacgcatcgt 3142621 aatggtattt ctttagttca tttaataatc ccatgttcag cagttccatc ccctgcggaa 3142681 ggctgatcag catttgtttc accttttcga gcacatttaa actttcattt tcatagatgt 3142741 ctctttctat ttgcttcatt tcagctataa attgttcgac aaccgcctca acaagctgat 3142801 ctttagatga ataatatgca tagagcgtcc gcttgctcgt tcccagcgct gccgccaaat 3142861 cattcatcgt aaatgaaaat cctttctgct tgatcagccg gaaggtttcc gccagaattc 3142921 ttttatccat attaatcccc cgctttcggt accaagaaaa ctatttcggt accaatatta 3142981 tacggcagaa atttatggaa atcaacaata tataaaaaaa cctctcctat tgggagaggt 3143041 ttaaaagaca ctgcggacca aaccgccgtc cgcccgaagt gccgcgccat tgatcgcaga 3143101 ggaaagcgga ctgcttaaaa atgtaacgaa gtgggcgatt tcttccggac ggatcagtct 3143161 ttgaataata gatgtcggcc ggttttcttt cataaaacgt gcctcagctt cttgaacagt 3143221 caggttttca ccaggataca gcgagttcag catggtttcc acaccctctg ttaaggtaga 3143281 gcccggcatg acggtgttga ctgtgacatt cgtgccggtt gccagctccg ccaaactgcg 3143341 ggaaatggac agctgcatcg tttttgtcgc actgtaatgg gccatttcct gtgacggcat 3143401 aatcgccgct tcactggcaa tgaaaatcac acgcccttct tttttctcta tcatgttatg 3143461 caaatacctg cgtgtcagcc ttacaccgct cataatattc acttcaaaaa aacgaaacca 3143521 ttcatcgtcg ggaatatcaa agtactccgc cggttcaaaa atccctaaat tgttgaccaa 3143581 aatatcaacc tctggatatg cctgaaacag ctcattgcag ccttcttctg ttcccaaatc 3143641 aaatgcagcc ggataaagaa ccgcttcagc atgttgtgtt ttcagttcat ctatcgtttg 3143701 attcactttc tcttcccggc gtccgttaat gatcactgcc gcaccttctt cagctaacga 3143761 agaggcaata gcttttccga tccctgatgt cgaaccggtc accagtgcgg tttttccttg 3143821 taaattcagc ttcattattc atccctccgt ttttgattcc tcttatttat tgacagaaat 3143881 ctgattggtg aaacatctgc tctgcaatca gtatgaaaca gctgggattg aaatggaagt 3143941 acgcactttt tggtgcctgt ggtttggaga aaaaataaag cagaacctct taagaggttc 3144001 tgctttattg tcagtatgta tggagacggt gggagtcgaa cccacgtcca gaaacatcga 3144061 ttacttaagc gtctacgagc gtagcctgca tatttatggt ttcactcatc ttcttgcctg 3144121 cgggcgggcc ttccgagagc tagtctgttc atctcttctt acgttctcag acgggaacgc 3144181 aagcgtagcc tacttggatg tgctcttcac agacacatag gcaatgtcag gaagagctcg 3144241 ctgcgcttat taggcagcta atgctacgtt ttggttaaaa ctgttagttt tgccagttat 3144301 atttaagtgc gtgtttacga gatcgcctct cggctcgcag ctcaagctcg atccatccct 3144361 gtcgaatccg taacgtcccc ttggtataag ggaaatacgg gagaaaatat caagctctca 3144421 ctcaaactgg ctatagtctt attataacat gatcacggct cttttcaatt gtcaaatcct 3144481 tcaaatgaat ggcgtcgtga tctgatcgtg aacacagtat agcacaggcc tgattttcga 3144541 atcaagcact atgcctttag aagccttttt gactgtctct gaacgctctt tcgatttccc 3144601 gcttcgcgtc cttgcgcttc agatcttccc gtttgtcata gttcttcttc ccttttccaa 3144661 ggccgagaag cactttggca aagccgtttt ttaaatacag cttcagcgga acgagagaat 3144721 agcctttttc ctttgttaac ccgatcagct tattaatctc cttgcggtgc attaacagct 3144781 ttcttgtccg gagcggatcg tggttatagc ggtttccctg ctcatatggg ctgacgtgca 3144841 tattgtggag aaacacttct ccccgttcga ttttggcgaa ggaatcctta aggtttacgc 3144901 ggccggcgcg aatcgatttg atttcggttc cttgcagaac gatgcctgtt tcataggttt 3144961 cttctataaa ataatcgtgg ttggctttct tattttgaga taatactttt cctgaccctt 3145021 ttggcatgcc agaacctcct ctctctaagg aaaaactgtc caccttttgc gatacgctct 3145081 attttaccaa atgtcacgta ccgctacaat gaaaagctgt ttccgaaaga aagcaaatag 3145141 agcgctgcgg ccctatttgc tggttgagct gctatttctt ctttttccgt ttctgtttcg 3145201 gagcattctg gaagccgcgt tttttctttt tcttcttcgg cttagtgaac cactcccctt 3145261 tttcctcaga cggagctgga gaaacaggtg tattggtgct ttgaacacgt tttctggcag 3145321 gctttccgcg ttttctgctc cggctgctgt ccaattctct cggacgccgc ggagtgcctt 3145381 tcatgccgac aatttcaaag tcgatattgc gctcatcttt attgacatcg acaaccttga 3145441 ctgtgatttc atccccgatg cggaagacgt tgcctgtccg ctcgccaatc attgcgaaat 3145501 gctgttcgtc aaagcggtag tagtcatctg tcataaagct gacatggacg agtccttcaa 3145561 ttgtattcgg cagctcgacg aacattccga agtttgtcac agagctgatc atgccgtcaa 3145621 actcttcacc gattttatca agcatgtatt ccgctttttt cagatcatcc gtctcacgct 3145681 cggcgtcaac tgcacggcgc tccatagatg atgtatgttc ggcgatatcc ggcaggcgtt 3145741 cagcccactt ttcctgtgtc gcttcatcga ccttgccgtt gatcaaatac gttcggatca 3145801 gacggtgaac gattaagtcc gggtaacggc ggatcggtga tgtgaaatgc gtatagaatt 3145861 ccgttgacag accgaagtgc cccaagcttt gcgggtcgta tttcgcctgt ttcatcgaac 3145921 ggagcataac agtagatata accgtttcct ctggtctgtc acgcacagcg tccagaatgc 3145981 tttgcagcgc gcgcggatga atattccccg ccgttccttt caccacatag ccaaatgtcg 3146041 tcacaaattc taaaaacttt tgcagctttt cagcattcgg ctcttcgtga atccggtata 3146101 taaacgggac attcatccaa tggaaatgct ccgcaactgt ttcgtttgct acaagcataa 3146161 attcttcaat cagcttctcg gcgacagagc gttctctgat cacaacgtct ttaaccgctc 3146221 cttcgtcatc aacaagcacc tttgcttctt tgaaatcaaa gtcaacggcg ccgcggtcca 3146281 tccgcttatc gcgcagaatt tgagccagac gctccatgtc tttgaacatc ggaacaagag 3146341 gctcgtattt ttgtttcagc tcttcatcat catcaacaag aattttattc acatctgaat 3146401 atgtcattct ttccgttgtt ttgatgacac tttggaagat ctcgtgctct gtcacctgtc 3146461 cctgactgtt aattgtcatt tcacaagaaa gcgtcaggcg gtcaaccttt ggatttaagg 3146521 agcagatgcc gtttgacaat ctgtgcggaa tcatcgggat gacacggtca accagataca 3146581 cacttgtccc tctttcaagc gcttctttgt caatcggcga gttttcggtt acgtaatggc 3146641 tgacatcagc tatgtgaacg ccaagcttgt agcttccatc atcaagcttc gtcacggtaa 3146701 ctgcatcatc caaatccttc gcatccgcac catcaatggt gacaatcacc tggtcacgga 3146761 gatcacggcg gtctttcaga tctttttcat caatcgtgtc aggcgtactt gatgcctgtt 3146821 ccatcgcgtc agctggaaat tctcccggca ggccgtgctt atgaatgacc gataaaatat 3146881 caatgcccgg gtcgtttttg tggccgagaa tggtttcaac ctcaccctct gcgttcatgc 3146941 ggccttcagg atagctcgtc agcttgacaa caaccttatg cccttccgca gctccatttt 3147001 tcccattttt cggaatgaag atgtcactcg tgattttttt gtcgtccgga atgacaaagc 3147061 cgaagtttct cgtttctgta tacgtgccga caacccgctg aatcgctctt tctaaaatcc 3147121 gtatgacggt tccttcctgc ctggagccgc ttgattgtga gttcagacgc accatgacga 3147181 tatcgccgtt cattgccgta tttagctcat taggcggaat aaacacatca cttaacgacg 3147241 tatcctcagg cagcaaaaag gcgaatcctt tcgcatgggc tgaaatcttt ccttttatta 3147301 aattcatctt ctccggaatg ccgtagcggt cgcttctcgt ccgtacgata agcccttttt 3147361 cttccaaggc gactaacgct ttgacgagct ctttaaactc ctcggcttcc gtaatattta 3147421 acatctcctc aagttcctga acggtcagag gtttgtacgc ctcttccttc ataaacgaga 3147481 gaagcttttc cataaatgct tctttttcca ttatccgacc tcctgttgat taccaatcga 3147541 gcttctctaa aaattcatac acatcctgat ggacgaggtc acgttctttg tcgagtgtaa 3147601 tgacatgccc tgattcctcg taccatttca gctgtttatc atcagtttcc acttcgttgt 3147661 aaataatatt ggcgctttcg gtattaatca tgtggtcatg acgggcctgc accacaaatg 3147721 tcggtgaata aatcatatcg acattattcc gcacatcagc aattaagtct tgcagcgcct 3147781 tgagggtatt catcggcgtt ttttcgaatt ctttcatttc ctcttcaatt tgctccgggc 3147841 ttttcccctc aaactttttg taattgcgag cgtatgaaag aacgccttga tacatgacct 3147901 cttcactctt aatatgcatc ggtgcgcaca ttgggacaat tccctttatg ggtacagtgt 3147961 aacccaattt cagcgaaaaa accccgccaa gcgacagtcc gcaggcagca atgctctcat 3148021 aaccttcaga ttttaaatat tcatagccat ccattacgtt tttccaccag tcttcgggcc 3148081 ccgtatgtac aagttcttca ggcgggacgc catgtccttc atattgaggc gcgtggcacg 3148141 tatagccgcg ttcattcaaa tatcgtccca gcatccttac atccgctgta tttcctgtaa 3148201 agccatgcag caaaagcacc gctttgtctc cgcctttaaa tgtaaatggt tttggtgtca 3148261 caactttcat gctcatgtct ccctttctat ctgcacgatc attttagttt tccacagttt 3148321 aatcagaaaa aaacgttttg aatatcatcc agaaacgtga aaaaggcctg acttcacatc 3148381 agaccttata caaacattgc cctataggat ataagcaagc gcaatcgtta acacgaaaaa 3148441 caagactgcc agcactaccg taatgcggtg caaaattaaa tcaagacctc ttgctttttg 3148501 tttcccgaag agctgctccg ctccgcctga aatcgcacca gataatccgg cacttttact 3148561 ggattgaagc aaaacgacaa taataagtgc aatgctgacg ataaccaata aggtaatcaa 3148621 aactgcgtgc atcccataca cctccagact cactggctac attacttcta ttttacatga 3148681 aaagggttgg catgtcacgc tgtatcagac gccaaaaggc cggataagac gttttatctt 3148741 ggttacccta ttcatatgaa aaggtcaaag gagaaaagcg atgccgctta tcagcataga 3148801 cagcaggaaa catctttttt atgaagaata tggacaggga atccctatca tttttatcca 3148861 cccgccgggc atgggacgaa aggtttttta ttatcagcgc cttctatcca agcatttcag 3148921 ggtgattttt ccggatttaa gtggccacgg tgatagtgat cacatcgatc agccagcgtc 3148981 tatttcctat tacgcaaacg agatcgcgca attcatggac gctttgcaca ttgataaagc 3149041 tgtgttattc gggtattctg ccggaggctt aatcgcgcag catatcggct tcacccgccc 3149101 ggacaaagtg tcacacctta ttctgtccgg cgcctacccc gctgttcata acgtaatcgg 3149161 ccagaagctg cacaaactgg gaatgtatct gcttgaaaaa aaccccggtt tgctcatgaa 3149221 aatcctcgct ggcagccaca caaaagacag acagcttcgc agcatattaa cagaccatat 3149281 gaaaaaagca gaccaggccc attggcatca gtattatctg gattcgcttg gctacaactg 3149341 cattgaacag ctgccccgcc tagaaatgcc aatgctgttt atgtatggcg gcctgcggga 3149401 ctggaccttt acaaacgcag gctattaccg aagatcgtgc agacatgccg aatttttcag 3149461 attggaatat cagggacatc aattgccgac aaaacaatgg aaaacgtgca atgagctggt 3149521 gacagggttt gtgctgacac atcattcata ggaatagaaa acgcttggct tccttgcgtt 3149581 ttttgttact ttattgactt ttgtcaacga aatcatagta aaaaagatcc tcaaatttca 3149641 aattaaaata gtgaagcatt ttaccaatca caagctgccc cggccttctt tctccattca 3149701 gcacgcggct cagtgtggcg ggtgagactc cgatttccag cgcaagctga ttaagggaat 3149761 aatcgttatt aaccatatac tgcaagacat aatcacgtct aatctgtatc ttttctactg 3149821 gcactttcct caccttccat tcctgaaaaa cttttttcta tacttttaca ttacggctta 3149881 tgttaacttt tgtcaataca tttccagtct acctattccc tttagtcaat aaacatacta 3149941 aaatatgagt aacagtgagg gacggggtga gatatatgga aagctttggc gaacaattac 3150001 gggcattgcg tgaagagaga aagttaacag tcaaccagct ggcgacttat tcaggcgtaa 3150061 gcgcggccgg catctccaga atcgaaaacg gaaaacgggg cgttcccaaa cctgccacca 3150121 tcaaaaaact ggcagaggcc ttaaaaattc cttatgaggg gcttatgtac aaggctggtt 3150181 acatcgaaga agtgcatgaa gccagggccc cttatgaaac gaagtgcaag ctgcttgaaa 3150241 aagcggaggc ctatgacctg aaaaaccttg cgcttcttga gaacgaaaag tggcaatatc 3150301 tcaataaaga agatttgctc atgctggatc attatttttc gtttatttca gatgaagcga 3150361 aaaaacggtc tgctgatgac tgactcttga tagaaatgtg aggcgataga ccatgtcacc 3150421 gttcggacag caattacggg agctgcgccg cgcccgcaaa ctgacagtga atcagcttgc 3150481 ggtgtactca ggcatcagct cggccaccat ttcaaaaatt gaaaacggca aacgcgggac 3150541 gccaaaaccc gccacgatta aaaaactggc agccgtcctg aaagtgccgt acgaaaacct 3150601 aatggccgcc gcaggccata ttcaggcctt tcctgaagaa atccgcgaag catctgaagg 3150661 ctatcaatcc gtttatgaaa tttaccagac ggctgtcaca cgcggagcgg agcacctccc 3150721 gattttcaat agtcaaaaat gggaacatct ctcaaagcag gatattgaaa atctcagcaa 3150781 atacttcgat tttttgtctt cagaagcaaa aaaacgcgcc tcttcctcat aatcccctgt 3150841 ttctctttct atattttatc aatcacgctt gcatgccctc cctcgttatt tgcgttataa 3150901 tagtgacaga cgaggtgaaa agtatgaacc aatcagaaat gtgtcctaga tttgaaaaag 3150961 cagtcgacat cttaagtaaa cgctgggtcg ctttaatcgt atttcagctc ttgaacgggt 3151021 cgcagcgatt tagcgaaatt gaagcagcac ttccaaatct aagcggcaga gttctgtcag 3151081 aacggctgaa agaacttgag cttgaaggag tagtgaagcg ggatgtcatc cctgaaactc 3151141 cggttcgcat cgaatattca ttgactgata aaggaaaggc actagcaccc atattaggtg 3151201 agatttctaa atgggcgact gaatggattg acccttcctt tcttgactaa ttgctaaaat 3151261 ggttctgatc tcaaagacga gaaaagaacc gttttttatt ttccaggtga aaaaaagata 3151321 tctcagccga tatatagtac atccacacat tacgttttta aaggagacca ctatatgcga 3151381 ctgacgattt cccgcaaatt cagcctggta tttttgacac tgatcctgat caatttactt 3151441 gtaggcggaa taggcgttct taatatgcag catatcattc aaaaaacaga tgaaatcaac 3151501 acaaaatgga ttgacggcat caaaggaatc acttcaatta attatgtaac cgagcacctg 3151561 tcttctaaag aaaaggactt tctgatttat acagacaaaa gtaaaatgga tacacttgat 3151621 caagaaatga atcaaatcat ggaagacatt aaccaaaagc tcgataacta cgaaaaaacg 3151681 atctccactg ataaagagca gaaactgttc gagcagcttc aaactaaagt gaatacctat 3151741 atggatattc atgcgcaaat tatcgaaagc ggccgcacga atgacatgga caaagcaaga 3151801 ggtttattgg ttcagactga ggccagcttt gaggatatga aaaaaacaat cactcagctt 3151861 gttgacttaa atcaagaagg cagcaacaca gcggtaaaag aaacgaaggc cgtctatcat 3151921 aaagggctca tttacactgc tttgcttgtg gcagcatcaa tcctcatcag cattttcatc 3151981 tggctttata tcacgcgaaa cattgtaaag cctatcattc gcatgaagga atctgccaat 3152041 catattgccg aaggcgattt gtcgaacgat atggaggccc tcaactcaaa agacgagctg 3152101 ggtgatctga atgaagcgct gcaaaaaatg gtagggaatc tgagagatat tgtcggatat 3152161 tctaaagaca tatcaagccg ggttctttct tcttcacagg tgcttgcaac cgcaacgaat 3152221 gaaacaagat ccggcagcaa acatattacc gagacgatga acgaaatggc tgagggctct 3152281 gaacagcagg cccaagacgc ggtgacgatt gccgaatcga tgaatgagtt taccgaaagc 3152341 attgataaag cctataatca cggcatcaca atcagcgata cgtctcaaaa cgttctcgaa 3152401 ctcgcggtaa gcgggaacga aaatatggct acgtcattac agcaaatgaa aaccatccat 3152461 catattgttg aagaagccgt gcataaagtg agatcactgg aacagcattc tcaggatatt 3152521 aacaagctcg ttcaggtcat caacgggatt gccgagcaga cgaatttgct gtcccttaac 3152581 gccgcgattg aagctgcccg cgctggagaa agcggcaaag gcttcgccgt tgtggcagag 3152641 gaggtcagaa agctggctga cggcgtttct gattccgtgc aggacattac ccggattgta 3152701 aacgggacac agcaggagat ccacactgtc attacgtact tggaaagcag ctttacagaa 3152761 gtcgaaaaag gaacggaaaa cctgacagac accggacagg ctatgcagca tatcaaacaa 3152821 tccgtcaccc atgttgcaga cagcattaag gaagtaacgg atggcttgaa gcagttaaca 3152881 aaccaatcga ttaccatcaa tcaatcgatt gaaaatatcg cttctgtatc cgaagagtct 3152941 gccgccggca ttgaagaaac attttcaatt accgagcaat ccgcccattc gatggatcaa 3153001 gtgcttctaa atgctgaaga gcttgagcag ctggccaatg agcttaatga gaagatgggt 3153061 cagtttacga tttaaagaga aaaaagaggc tggactccag cctctttttc tattctatgc 3153121 agctgattga acatgtttcg ccccggttct ttttttcttc accggactta atgcccgctc 3153181 cagccaagcc atgagcaaat ccgcccctac cgccatcacc gcagttggta tcgctccggc 3153241 tagaataatc gcagttccgt ttgttgcgtt tgagccgcgt acgatcatgt ccccaaggcc 3153301 tccggcaccg acaaatgtgc cgatcgctgt aattccgatg gcaatgacga gagccgtgcg 3153361 aaggcccgcc ataatgacag aaagtgcgag cgggagctca accattctga gcacttggaa 3153421 tttcgtcatg cccattgctt ttccagattc taagtaggca tgttcaatac tgataatgcc 3153481 tgtgtacgtg tttcgaataa tcggcagcag ggaatacaga aataatgata gaatcacggt 3153541 atttgcgccg agccccataa caagcattaa gacggccagc atagcgagcg ccgggattgt 3153601 ttgaataacg tttgttacgg caaacaccca ggctgacaaa cggcgaaaat gcgcgatgag 3153661 gattccggcc ggaaccccga cgacagcggc aaataaaacg ccgtaagccg acatgagaaa 3153721 gtggcggccg aattcatcca tgacgtaact gccattctgc gcgtaatacg tcattaactg 3153781 ttcaagcacg ttcattgacc tcttccccct ttcacgattc gaaatagcga tgtttttcta 3153841 aatattcctt ggcaacgaca gacggttctt tgagattgcc gtcgacttca tagttaagct 3153901 cctgcatcgt ggctgtgtcg atttttccga gcattttctt gatgatgcct tcaagttcag 3153961 gatgttcttt gagcaccttt tccggaacaa ccggagagca gtcgtacggc gggaaaaatt 3154021 gtttatcatc ctttagcatt ttgagaccat aggacttgat tcttccatcg gttgaatacg 3154081 caagcacaat gtccattttt ccgcttttca ccgcgtcgta cacaaggccg atctgcatcg 3154141 gatacgtgcc gccgaatgtc atgccgtagg ttttcgtaaa atcctgatag ccgtttcctt 3154201 tgagcttcat ccaatagtta tcaacgccca gctttaattg cggcgcccat tttttaacgt 3154261 ctgatacggt ctctaaatgg tattggtcgg ccagctcctt gctgactgta aaggcatatg 3154321 tattatcaaa cccgtaggag tcataccact ttaaatcata tcttttttta aactcccgct 3154381 gagtaagcgc cagcgctttg tccggatctt tttcaggttc cattctcaac gtgcctgtca 3154441 gcgcgtctcc cgtatatctt gtggccgcaa tgtcgatttc cccgttcatt aaagcctgct 3154501 gctgcaccgc gttggagcca agatttttaa tcgttgttgt tttgagatca gtatggtgtt 3154561 cgatcaactg gccaagcatg ctggcgatga tttctgattc gctcatgctt tgcgcgccga 3154621 ttttaatggt ctggtctgca gcagcgctga gaccaggaag cgaacagccg ctcagcgtca 3154681 gcgttgccgc aagtgctaaa cctatcatta atttgagata ttttcttttc atgagccgcc 3154741 tccttatgac aattccttca atctctgcat gccggcaggt gtcagttttc gttcagcaac 3154801 tgccagcaca taatcaatca caattgccaa tatcgtgaca ggtaccgcgc ccccgatgat 3154861 atattccggc tgatataaat tcagtccgat aaaaatgtaa tcacccaatc cgccgcctcc 3154921 gataaaggaa gcaagcgtgg cccagccgat taagtaaatc gtcgatgttc tgattcccgc 3154981 catgatcact ggtgcggcaa gcggcagctc caccaagcgg acttgttcag ccggcgtcat 3155041 tcctattcct ttaccagact cgagcagatt tttgttgacg ccgcgaatgc cggtatacgt 3155101 gttgcgaaga atcggcaata cggaatagaa aaacaaagcc acaatggccg gaaccttccc 3155161 tacaccaagg agcgggataa aaaaagcgag gatggccaga ctcggcagcg tctgaatgat 3155221 attgacaatg ccgataatgg tgccggctcc ttttttcatt ctggtaagca caaccccgag 3155281 ggggacggca accagcacac ctaagatcac agcaatgagc gatatcgtaa tatgctcgta 3155341 tgttttataa agaagctctc ccccattggt ttgcaaaaat tgaacaatat gatgcatgac 3155401 ttatcgcccc tccctatgac aatgctgcga gctgcttttc ttctccccag agggagtcat 3155461 acacgatgtc gaccagactt gccctcgtca caattccgat caggcgtcgg tcttcatcca 3155521 caacgggaac atatttgaca ccccgtttta aaattttgcg gaccgtgtcg cgcagcagtg 3155581 tgccgcccag tactgtgtat atatcttcat gtaaaacttc actgacgaga ttggcctttt 3155641 tccggcattg atcaatgatt tcaacatcga catagccttg cagaacgcgc tcgtcattga 3155701 cgaccagcaa tgaatcgacc cgttcctgcc tcatcagctg aatggcctca gaaagcgttt 3155761 tatccgcggt gatcgttaca ggctgtgtgt tcataatctg gtcaacccgt tcaacatccg 3155821 ggctggatga ctgaatcagc cgctccttgc cgataaattc ctcaacaaat tcgtctgccg 3155881 gatttcttaa aatgtcatcg ggcgttccaa cttgaacgat ttctcccgct tttaaaatca 3155941 caatccggtc tgccagctta atcgcttcat ccatatcgtg ggtaacaaat acgatggttt 3156001 tatgtaaggt tttttgcagt tttttaaatt cttcctggag ggaatccctc gtaatcgggt 3156061 cgagtgcccc aaacggttca tccattaaga taagcggcgg ctccgcggca agtgcccgta 3156121 atacaccaat tcgctgctgc tgccccccgc ttaattcatg agggtaacgg tctacatatt 3156181 ctggccccat atcgaccaat tttaaaagct cacgcgcccg ctctttccgc tgctgctccg 3156241 gccatttcag cagttttggg acgagtgaga tattctgctg aatggtcata tggggaaaca 3156301 ggccgatctg ctgaatcaca tagccaattt tgcgcctgag ctctacagga tcctggtcca 3156361 tgatgttttc gccgtcaatg aaaatcttcc cggcggaagg ctcaattaat cggttaatca 3156421 ttttcattgt tgtcgttttt ccgcagccgc tcggcccgat aaagcagata aattcgcctt 3156481 ttgcaatctt aagatttacg ttgttcacgg cttttttgcc gcccttgtat gttttcgaga 3156541 cattttctaa tgtcagcaaa catcgcacct ccaaaattaa gtttattcaa tttgttcagt 3156601 ttaaatttaa tttttcagac aattgaatgc ttcccattat agaataaagt ttataaaata 3156661 aaaagtttac aatttgttca tattatttat aaagtatgtg taaacgctga tttacccgca 3156721 ttgacgtgtg ttgatctcct tattgctcca atttcctgcc aaattctctt ttgacagcat 3156781 tttcgccgta tcaaaaatgt ggtatattga catcggaatt gttagctgaa aggatgaaac 3156841 cgttggagaa agatccgtta acgatcattg aacaagccga ggaccatttt atagaaagaa 3156901 tcgcggaaaa catgcatgca tttggaatgc cctctaccgt cggacgagtg ctgggcatta 3156961 tttatatgaa tcgaaaaccg atgacgctta cggaattatc tgaggccacc ggcatgagta 3157021 aaacacgtat gagccaggta gtgcgggaaa tgcttgatgc caacattgcc gagaaggtat 3157081 tcgaaaaagg cgtgcgaaaa gatttatatg aggttgagca ggactactat caaacattta 3157141 tcacgctgtt ttcagccacc tggagcaaag tcgtcagcaa aaacaaaatg atgcataaaa 3157201 aactcaatcg ggagctgctt agcgtgttgg atgaagagct tactcctgaa gcggaagaaa 3157261 aagtgaatga gctgctgaag gaattaaagg aatggctcga ttattataat tggctcagcc 3157321 gtttgattga gttttttgag agcgaagaca tttttaaata tgtgccgaag ccgtaaaaag 3157381 ttcccaaatt caattctggg aactttttta agtccaatcc aaatggttga atatcaaact 3157441 tcaagaaaac aaacaaaata atgcataatt tacattaatt tattaattat ccattttttg 3157501 ttgattattc tgactagcta ttatataatc tttttgaaat gattatatta gcttagagga 3157561 ggtaatctac atcaaaaaaa agggaattat tactgtaatg actatatgtt tcctattatt 3157621 ttcttcttat tactttagca atatttcacc tcagaatcca ctgttcaaaa aaaatttttt 3157681 gcaacaattg tctccccaag gctttggctt ttatagtaaa agccctacag aagaaaacat 3157741 ttcatttcac acaaaagaaa atttaaagtt acctaatgca cttcccaata atttttttgg 3157801 gataaaaaga gaaggaagag ttcaggcaat agaattaggc aaaattgtag agaatatcga 3157861 tccaaagaat tggaaaactt gtgaaaacaa caactcctgc acaaatttag agaaacaaat 3157921 aaagcctatt aaggttataa aaaatgaaga ttatatacat cttagcaaag gagaatacct 3157981 aatatatcgc caaaaaccac tctcatggta ttggatagac tttaagcaaa ctacctcttt 3158041 tgaaagaaag gtgctaaaaa taaaaatagt atgaagatat taaatagttt agaaggttat 3158101 attgacacct ataatccatg gaaaaataca tatgcacttt ttagaagttt acttggtttc 3158161 tcaacattac tagtactatt attcaatagt actgatattt tatttagtta tagtgcaaat 3158221 aatgtcacat gtgaaaatgt ctatatccct accgcttttt gttttgctaa agaatatagt 3158281 atcaattttg agattataag atacttaatg atttttatat taaccttagt ggttataggg 3158341 tggagaccta gatttaccgg tttatttcac tggtatattt gctatagtat tcaaacttca 3158401 gctttaacta tcgatggtgg agagcaaatt gcaactgttc tttcttttct tatattacct 3158461 gttacattat tagattcaag gcgaaatcat tggaatataa agaaaaacaa taatgaatct 3158521 ttcacaaaga agacagtatt gttttatata atgacaataa ttaaaattca agtttttatc 3158581 atttatttaa acgcagcttt agagcgattg aaaaataaag agtgggcaga aggaacagca 3158641 atttactatt tcttttctga tccggtgttt ggattacctg aatatcaact taacttaatg 3158701 aatccactac ttgaaagcaa ttttattgtt gtcatcactt ggttagtaac tatttttgag 3158761 ttgttcttag cagcaagcat aatttcaaat atcagaataa agagaattgc ccttgttttg 3158821 ggaatattat ttcatattgg gataatattc agcattggta ttgtaagttt tggcttgatc 3158881 atgatatcag cattaattat atatctgcat cctgtacaac aaaatatcac tatgaattgg 3158941 tgttctcctt tatttaaata tatatatgta aaaggaaaga gaaatttcaa aagaatagga 3159001 ggtgaatcag tcaagtttct tacaaaattg tttcatagct aacatttaga taatggagaa 3159061 ataacttaat ggaggtataa taatttgaaa agtaaattac ttaggctatt gattgtttcc 3159121 atggtaacga tattggtttt ttcattagta ggactctcta aggagtcaag tacatctgct 3159181 aaagaaaacc atacattttc tggagaagat tactttagag gacttttatt tggacaaggg 3159241 gaagttggta aattaatttc aaacgatttg gaccctaaac tcgtaaaaga ggcaaatagt 3159301 acagaaggta aaaagttagt aaatgatgta gtcaaattta taaaaaaaga tcaaccacaa 3159361 tatatggatg aattgaaaca atcgattgac agcaaagacc ctaaaaaact cattgaaaat 3159421 atgaccaaag cagaccaact tatccaaaaa tatgctaaga aaaatgaaaa cgtaaaatac 3159481 tcttctaata aagttactcc atcttgtggg ctttatgccg tctgtgtagc agctggatat 3159541 ttatatgttg tgggcgttaa cgcagttgca ttacaaacgg ctgccgcagt aacaactgca 3159601 gtgtggaaat acgttgccaa atattcctct tcagcttcta ataattctga tttagaagcg 3159661 gctgctgcaa aaaccctaaa attgattcat caataatcca ttataattga gtgtcttgcg 3159721 gattgctccg caagacactt tttcaacgtg aaccgtttaa ttttttgtaa taatgatatg 3159781 aagctagtgt tgaaataact aatgctagaa gaactagcac aatcataata agaattatat 3159841 attctcctgt aaaaaatgaa agaacagcta ttataaaacc acacactaca agtactttag 3159901 aggcaaagcg atttcccagt ttccaaacag tctcatcttt taatgtccaa ggtgtcctca 3159961 atccaataag atggttttgt tctgctagct gcatagaatt tccaccaata attaaaaaga 3160021 taccaacacc aagccctatt attaaatcaa tattcacttc gtatcctaaa cttatcaata 3160081 gagttgagag ttgtaaaata tataaaagga ttaacatatt attagaagct aggaaaagca 3160141 atgctttatt tttttgtgta gacttaatag ttaacatata aaaagtaaga taataaataa 3160201 gcataacaac aggtataata aatattgtta aaggtttaga tacaattgca gccggtttat 3160261 ttcctgacca ttgtatcggt atttcttctg gaaggtattg atataatata attgaagtca 3160321 agaaactcaa acatacaata attatggaaa ttatattttt cttcataaat cgttatcccc 3160381 tttatttata aagttaagca tccaatttat tgagtcttga agtactgttg tatttagaga 3160441 gtaataaata aattgtcctt tgcgatggtc acttatgact tccgcttgct ttaaaatatt 3160501 caagtggtgc gaaatactcg gtttgctgat attaaaatgc tcagcaatat ctcccgcagt 3160561 catatcccct ccttttaaca aatccaaaat ttttctcctt gttggatctg atatagcttt 3160621 gaaaacatta ttcatagcgt tttctccttt acaaaaaaac atttagacat ttagatattt 3160681 gtataaatgt attattttca ttataacttg aattttttta aaaacaaccc tcaaattggt 3160741 tataatatct gatttttgta ttttttcaaa tactcggata atcccaacgc tggaaaatat 3160801 gtttaacaga tactaacaca tgttgtttat ttaaaaaaac cacctctgtt gtatttaaat 3160861 agaggtggtt tttctatcag ctataataaa atttcctttt ttctttttaa tcgggcttaa 3160921 tgctcgttca agccagccca tgaccaaatc ggcaatcacc gccatcagag ctgtggggat 3160981 cgctcccgct aatataatcg cggttccgtt tgtggcgttt gatcctctga cgatgatgtc 3161041 cccgagaccg ccagcaccga caaatgtccc gatggccgta atgccgatcg caatgacaag 3161101 cgcggtgcgc aggccggcca ttatgacaga aagcgcaagc ggaagctcga ccatccgcag 3161161 cacttgaaat tttgtcatcc ccattgcttt tcccgattca agataggcgt gctcaatact 3161221 gataatccct gtatacgtat ttctgataat cggcagaaga gaatacagaa ataatgacaa 3161281 tatcaccgta ttagcgccca gccccatgac aagcatcagc acggcgagca tggcgagagc 3161341 cgggatggtc tgaatgacat tcgtgaccgc aaaaacccat ccgcttaatc ttctgtatct 3161401 ggctatcagg atgccgagcg gaattccaac aatggcggca aataaaacgc catacaccga 3161461 catcagaaaa tggcggtaaa attcctgcag cacgtaaccg ccgttttgcg aatagtatgt 3161521 gccaagctgc tgtagtactt ccatatgatc cacctctttt cttagtcaaa ataatgatgt 3161581 ttctctaaaa attcctttgc tacgacagac ggctccttca gcttgccatc cacctcataa 3161641 ttaagttcct gcatcgtttc cgtgtcgatt tgcccaatca gcttattgat cacaccttca 3161701 agttccggat gctccttaag caccttttcc ggaatcaccg gtgaacagtc atacggcgga 3161761 aagaaacgct tatcgtcttt taagattttc agatcatatg ctttaatccg tccatccgtt 3161821 gaataagcca aaaccgcatc cattttcccg tttttgactg cgtcatagac tagcccgatc 3161881 tgcattggat aagttgtgcc gaactcaaag ccatatgtgc tgacaaagcc tttatacccg 3161941 tcgccttttc gtttcagcca agcattgtcg acgcctaatt tatattggga agcatttttc 3162001 ttcaggtcag acacggtgtt aatatgctcc ttttccgcaa acttttttgt tacggtgaag 3162061 gcatatgtgt tatcaaagcc gtaggaatca aaccatttat aagaaaagcg cttttgaaac 3162121 tcgttctgca caatgttcag cgcttttttc ggatctttct ccgcttcctt gccgagggtg 3162181 cttgttaaat ctgttccgga atagcgcgtg gctgaaatat caatgtcacc gcccagcatc 3162241 gcttggtgct gaacatagtt tgagccgagg tttttcacta aagcagtatt caaatctgta 3162301 tcatgttcaa taagctgcgc gatcatattc gctacaattt ctgattctgt catgctctgc 3162361 gccccgattt tgatcgtatc gtcagaagcg ccgcctagac ccggcagaga gcagccgcct 3162421 agcagcatga caaagacgag agcaaacgcg ccaagccatt tgatttttgt cattttcaac 3162481 agtgccaact ccttacgata cttccttcat cccttgcaag cctttcggcg tcacctttcg 3162541 ttctgtcaca gccagaacat aatcaataat aattgccaga attgtgacag gcacggcacc 3162601 gccaatgata tattcaggct ggtataggtt cagtccgata aaaatatagt ccccgaggcc 3162661 gcctcccccg ataaacgacg caagtgtcgc ccagccaatt aggtagatcg ttgatgtgcg 3162721 gatccccgcc atgatgatgg gaatcgccag cgggatttca acgagccgaa tctgctccca 3162781 gccggtcatg ccaattcctt tccccgattc caggaggttt ttatttacac ctttaatgcc 3162841 ggtatacgta ttgcgcagga tcggcagtac cgaatagaaa aataaagcga caatcgcagg 3162901 cacttttcct acgccgagaa gcggaataaa aaaggctaaa atcgccagac tcggcagggt 3162961 ttgcacaatg tttacgaaac cgataaccgc acctgcgcct tttttcattc tggtaagagc 3163021 aacgccgagc ggcactgcaa cgataatgcc caatacaacg gctatgagtg aaatatataa 3163081 atgctctcct gttttataca gcagctctcc gccgttcgtt tgcaaaaaag tcatcatttg 3163141 attcatctta aaagagctcc tcccctggtc agatcgtcat gagctggttt tcctcgtcgc 3163201 cccaaatgga atcgtatacg atatcaacga ggctcgctct tgtcacaatc cctgctaaat 3163261 ggttctgttc atcgaccacc ggaacatact tgatcccctg cttcaaaatt tttcggactg 3163321 tatcgcgaag aagcgcccct ttttgaacgg tatatatatc tgaacggtat acatcgccaa 3163381 cgatgctcgc ttttttgcgg ttttgatcaa tcatttccac atcaacatag cccttcagca 3163441 cgttttgccg gtccacaacg agcagcgagt caacacgttt ttctctcatc agctgaatcg 3163501 cctgagaaag cgttttgtcc gcagataccg tcaccggcgt tctgttcatc atttgctcta 3163561 cccgctcgat atccggtctt gactgaatca ggcgctcttt cccgataaat tcttcaacaa 3163621 actcatttgc cgggtttcga agaatctcat caggtgtgcc gacttgaacg atttctcccg 3163681 cttttaatat cacaatcctg tcagcaagct taatcgcttc atccatatcg tgggttacaa 3163741 acacaatcgt tttgtttaag gttctctgca gttttttgaa ttcttcctga agggaatcac 3163801 gcgtaatcgg atcaagcgct ccgaacggtt catccattaa aatgagaggg ggttccgctg 3163861 ccagggcgcg cagcacgccg attctctgct gctgtccgcc gctgagctca tgcggataac 3163921 ggtctaaata ctctgggccc atatccacaa gctttaacag ctcgcgcgcc cgttctttcc 3163981 gtttttcctc aggccatttc agcagctttg gtacgagtga gatgttctgc tggatggtca 3164041 tatgggggaa caaaccaatc tgctgtatca catagccgat ttttctcctc agctcaaccg 3164101 ggtcctgttc cataatattt tctccgtcga taaagatcct tccagacgat ggttctatca 3164161 gtctgttgat catcttcatc gtcgtcgttt ttccgcagcc gctcgggccg ataaaacaga 3164221 taaattcacc ttttgcaata tctaaatcaa tgctgttcac agcttttttg ccgcctttat 3164281 atacttttga cacttgttcc aatttcagca atccgtgcac ctccgcaggt ttcctttaaa 3164341 ttttctgaaa agtataatcc ttattatagt ttgaactttg taaaataaaa agtttacaat 3164401 gtgttgaaat tatatgttat ttatagatta tttattgtta tgaccgagac ggaaagggtg 3164461 ttcttacaat tactccggat acctcccact tcctctgcat tcagctattt tcaacaccag 3164521 gaagaaatat gatatattga caccatcaat tgccatttga agggatgatc agctgtgaaa 3164581 aaaaccgctc tcgacatcat tgaacatgct gaagagcatc tcattgagaa gattgccgaa 3164641 aatatgcata cgtttggaat gccttcaact gtcggacgtg tgctcggaat tatttatatg 3164701 aatcgaaaac caatgacctt aagcgagctc tctgaggcaa cgggcatgag caaaacacgg 3164761 atgagccagg ttgtccggga aatgatcgat gccaatatcg ccgaaaaggt gtttgaaaaa 3164821 ggcgtacgaa aagaccttta tgacgtcgag caggattatt atcaaacctt catttcttta 3164881 tttgcggcga attggacaaa ggtcgtgagc aaaaacaaag tgctgtataa aaaattaaac 3164941 cgggagctga gtgatctttt acaaagggac gggcttaccc cggaagcgga agagaaagtc 3165001 aatcagctgc tgaatgaatt aaaagaatgg cttcattact atgattggct gagcaggttg 3165061 attgaatttt ttgagagtga ggaagtcttt cggtatgtgc cgaaaacaaa agaatgcagc 3165121 tctctaaaat aagagagctg ctttttgcat catgaagtta agaccggaaa catgcctttc 3165181 agcccggcac caatcatccc gaccgcaacc acggctaaga ttaatcccat cagtctggta 3165241 atcacattca tctcggtttt tccgagtttg ctgctgataa aagcagaata gtggaaaaag 3165301 agaaaggtca gggcaataac ggcggctatg ccgatcatga cagccgcata atgaccaatg 3165361 ccgctatgtc cggcggaaag gctcatcact gttgcaatcg ttccgggccc agcaatgatc 3165421 ggaatggata aaggtgtgac tgatatatcc gctttttcct tgctttcctt atgttcatca 3165481 tggtgaagag attgcacgtg cgattctttc gcattcaata gattataggc aatgccgaaa 3165541 atgaatatgc cgcccgccac tcggagcgcg tgaatgttga tatcaaacag tttaaagata 3165601 agatgaccga aaaccaaaaa agctgcgaga ataaaaaagg ataaaatagc tgccttccgg 3165661 gcaatcgctt ttctttccgc tgcagtatag ccttctgtca gcgtcagaaa tatcggtacg 3165721 tttccgatcg gattcgatac tgcgaataaa gaaatgaaga cgtgaacgat aaatgagaac 3165781 atcatatacc tccttgttga tagtctctgc acaggaaata gaatgattct ccaccctttt 3165841 acccggaggc gatttcccgg taaaccttta tagcctgtca gaaacgcgcc atgctacaat 3165901 gaagtgacaa attgaatagg aaggacgtat acagatgttc aaaaaaattg cggcagatgc 3165961 cttgggctta tctgatatcg gaaaaattat cgaacctcag gactatgaca aaacagacgc 3166021 agatgactat gtcatgcatg aagataatga gaaaatttat ttcttgatta aaacaaaagc 3166081 agacgagtat tgctttacga acctggccct gatccatgtg gacggcgaac gcgccacttc 3166141 ctcaaaacga acgttgaaac gctatcctta ttcgcaatat aaaatctctg acgtttttct 3166201 tgaaactgcc ggaaaagtgg atttggatgt tgaaattaag ttcaagctgg gcggtgaaca 3166261 attcgacatt gatgtccaca aagaccagat tgaaaagtta aaagaccttt ataaagcact 3166321 gcttcgcatc gctgaaacaa cctatgaaaa tgacatttta atcaatcaag cggagcaaag 3166381 cttagataaa gcagtgacga ttcttcacca tacccgccct gagcacgtca atattgaaac 3166441 gcaatacaaa gagctgaccg aattcggatt cacttggctg acatccgttc gctcgcagta 3166501 tcatattaag gattttgggg atgtatttga gaaatatatt aataactaga taaaaaaaga 3166561 cacagctgct atcgtgctcg tgtctttttt tgtatgaata ttgattactt tacaactttt 3166621 ttcttttata ataaaactat tagtctattt tccctatatt acagataaag gagttatttt 3166681 atgtattgtc ctcaatgcgg ccatcaaaca gatggcggaa atttttgtga gaaatgcgga 3166741 tcaccgctcc ccggtcaatc aggccaccag catgcagctc aaactggagc cgctgcaaag 3166801 caagcagcaa aacagttcgg ttcatttgtc ttatccgtcc tgaaacgccc ttatcaggaa 3166861 tgtaaagcaa caggcggaga acagctgatc agcgcaatca ttacgatggt tcttttcagt 3166921 ttgctgaccc ctttgatgtt ttatattctt ttttcagacg gtcccggaag cgtaagcttt 3166981 acagcaatct tcttagagcc aaccatttat tttattttat ttctatttgg cctgcatgca 3167041 tgcatctttt tcgccctgaa aatcgcggga aaccaagtgt ctttcaagga ttcattctca 3167101 agattcggag catttcttat tccttttacg gctattttga ttcttgccct tttcttcttt 3167161 ttattacata cagacatttg ctttaccata ttagccgttg gtttaatcgg tgcattcttc 3167221 gccattcctc ctgcgatgct gagcagttac cagcattcat ataaagggaa ggttgatttc 3167281 atttactcaa cgattgtgat ttatctgatc atctgcgtta catttcagct tattatcgaa 3167341 cactatgtca aagaaatttt ccgttatatg ctcttttaaa aacaacccca tcacctgctg 3167401 gtgatggggt tgttttattg aatagacgtt aagtaaattc ttccgttctt cactacgccg 3167461 gtgtaggtcc agttatatgt tctgagcttt ggactgccgc ctgattttgt gatatagaat 3167521 tcttcatacg tcttaatcgt gatagccgac ccattttggc tccagctttt cacttcatag 3167581 ttattaaagt cttctgttgt cccctcttta tttaatttcg acacgagatg ctgctggtcg 3167641 gaataaaggg aactgccttt ttcaaggctg tcttccatca gtgagaaatt attttgattc 3167701 acggcatctg cctgactttg cagataactg cccataaata atgtcacttg ttcatctgta 3167761 acatcgccgc ttgcagagct ttcactgcct ttgtttttcg agccagccca ggcggaagtg 3167821 tatgtctctg gtttatcatt tttgattttc tttatatttg tgcctgcaga ttcgaatgtt 3167881 gattctgcat cttcgaaaat ccactttttc tgttttttat catatgaaag aagatattca 3167941 taactcggac tgtcgtcagt catttcagac tttgtatagt cgttatacga agaagactgg 3168001 tgaagttctt ttcctgttac cgatacctgc cacgttccgt cgtttttctg agagagggca 3168061 aatgtgtcca ggtcaaaatc agtttccaag tatctatctt ttaagtatga atccgcgctt 3168121 ttcatagaat cgacggtgtc cttcgtctcc gccttccaat tggcacttgc ctctgtcatc 3168181 tgggctgtat tcccatcaga tagagctttg gagtattgtt ttgttgtttt gacaattgtg 3168241 ttcataatct gttcctgtgt atcttgatca ggaattaacg ttaactccat ttctttatca 3168301 tcgatcggaa cgccggcagt ttttgttttt ccccacggaa attctgcctc gactgaagct 3168361 gtcattgatc catctgtcag cagcggacca tatgttacgg atttgaacgg atctttatga 3168421 attgatttac cgttaatcag caaatctccc ttcccgctct tgatgtcatt cgctaagctg 3168481 aatgtcacat cgtctgcttc caatgagaga tcaacacgaa agctgctatc gccaatcgcc 3168541 tgaatgtctt cctttttcac aaggtcaacg acatcgtttt tcagtttggc tgagactgta 3168601 tattcgccgg gaatgtacgg accaagggtt tgtgcttgat ctgctttctt tacagatccg 3168661 gcttcctctt tattgacata tagatcggta tttttataat tgctgctcac ttcaaaataa 3168721 acaggtgcta cctttaagtc ataatggtca aataccagca ggcttttccc gtctttttcc 3168781 gcatatacga tatccttctg ggctgtttca tcacgcagcg atgcaaaaag ttcatctttt 3168841 ttgtctggat gatccttcaa atatgtaaga aacggtttta cattattttt agtgagttta 3168901 agattgtcat ttaccggtgt aagcagagtc gcgatttggt cctgatcccc atcatttacg 3168961 gcctgttcaa acttgtctac taacctatcc tttgaagtaa aatacgctcc ggttttatat 3169021 gcggcgaata atataacgca cgccgcggca atgctgctcc ataaaatgat ggttttctta 3169081 gggatcggtt ttcgcggagc ctgcctcgtt tctgcagtgc tagctgtttc ttgatttgcc 3169141 tgtttgctgc cccctccgat cggggtgccg cattgtttac aaaacttggc tccttcatta 3169201 ttctgggagc cgcaattctt acaaaataac atgactttcc tcctattcta ctaatttgat 3169261 aacatttact gcttttcata ttttataata aaacagaatg aaattgggaa cgaatgaaaa 3169321 aattaaatgt ctatcagact aaaaaggtgg aatgaatatg caaaagctca ggattgaatt 3169381 aggagaagaa acaaatgacg aattatatga tctattgctg ctcgccgatc catcgaaaga 3169441 cattgtagat gaatatcttg agaggggaga atgttacaca gcttgggccg gtgatgagct 3169501 tgcaggggtt tatgtattgc taaaaacaag gccgcaaaca gttgaaattg taaatattgc 3169561 ggtaaaagaa tctcttcaga agaaaggctt tggcaaacag cttgtacttg acgccatcga 3169621 aaaagcgaag aagctggggg cggacacgat tgaaatcgga acggggaatt cgagcattca 3169681 tcagctttcc ctctatcaaa aatgcggatt ccgcattcag gcgatcgacc acgatttctt 3169741 tctcagacat tatgatgagg acatttttga aaacgggatt caatgccgcg atatggtaag 3169801 gctttatttg gatctctgaa agcataaaaa agccgccgag agaaaatccc ggcggtcttt 3169861 ttattacttg tttaagttgt agaaagagtt gataccgtgg tattgagcag tttcagccaa 3169921 ctgatcttcg atgcgaagaa gctggttgta tttcgcaaca cggtccgtac gagacggagc 3169981 acctgttttg atttgtcctg cgtttgttgc cacagcgatg tcagcgattg tgctgtcttc 3170041 agtttcacca gaacggtgag agataacagc tgtgtagcct gcgcgtttcg ccatttcgat 3170101 cgcatcgaat gtttcagtca atgtaccgat ttggtttact ttgatcagga tagagttgcc 3170161 tacgccgttt ttaatacctt cagaaagttt tttcgtgttt gtaacgaaga ggtcgtcacc 3170221 aacaagctga acttttttgc caagacgctc agtaagaagc ttgtggcctt cccagtcgtt 3170281 ttcgtcaagt ccgtcttcga tcgagatgat tgggtattta gaaacaagct cttcatacca 3170341 gtcaaccatt tcagcagatg ttttcacaac gccttcgcca gacagatggt atttgccgtc 3170401 ttctttgttg tagaactcag aagatgcagc atccatagca agtttaactt cttcgccagg 3170461 tttgaagccg gctttttcga ttgcttcaac gattgtttga agcgcttctt cgttagaacc 3170521 aaggtttgga gcgaatccgc cttcgtcacc tacagcagtg tttaagcctt ttgcgcttaa 3170581 tactgatttc aggctgtgga agatttgagc gcccatgcga agtgcttcac ggaagttagg 3170641 agcacctaca ggcatgatca tgaattcttg aatatccacg ttgttatcag catgctctcc 3170701 gccgtttacg atgttcatca tcggtacagg aagcgttttt gagttgaatc ctccaaggta 3170761 ttggtaaaga ggaatctgta agaaatcagc agcagcacgc gcacaagcca tagatacgcc 3170821 aaggattgcg ttcgcaccaa gtttgccttt gttttcagta ccgtcaagct cgattaaaag 3170881 ctgatcgatt gcgttttgtt cagttacatc aaagccaaga agctctggag caatgatttc 3170941 gtttacgttg ttaacagctg ttaacacgcc ttttccaagg taacggtctt tgtcgccgtc 3171001 acgaagctca accgcttcgt attcacctgt agaagctccg cttggcacta atgcgcggcc 3171061 gaaagctcct gtttctgtat atacttcaac ttcaactgtt gggttgccgc gggagtctaa 3171121 tacttcgcgt gcataaacat caacaatgta tggcatgagt tttgtctctc cttttgattt 3171181 tcaaattatt tttgaattaa agatgttcct gtcatttctt tcggtttttc aacaccaaga 3171241 aggtctaata acgttggtgc aaggtcgcct aggattccgc cttcacgcag cgtaatgcct 3171301 tctttcgtta caatcacagg gactgggttt gttgtatgcg cagtgtgcgg ttcgcctgat 3171361 tctgtaatca gaatgtcagc attaccgtga tcagcggtaa tgatagcgtg tccgccttta 3171421 gcaaggatcg cgtcaacgac ttcgcccaag cattcgtcca ctgcttcaat tgctttaatt 3171481 gttggttcaa ccattccgga gtggccgacc atatcagggt ttgcgaagtt aagaatgatc 3171541 gcgtcatgct tgtcagcttc aatttctttg acaagcgcgt ctttcacttc atacgcactc 3171601 atctcaggct tcaagtcata cgttgcaact ttaggcgagt tgatgagaat acgctcttca 3171661 cccgggaatt cagcttcacg gccgccgctc ataaagaacg tgacgtgcgg atacttttca 3171721 gtttctgcaa ttcgaagctg ttttaacccg tgctgagata atacttctcc gactgtgtta 3171781 tcaagattta tcggtttaaa cgctacatag ccgtcaactg tttcactgaa gtgagtcagg 3171841 cagacgaaat acaggttctt tggataattc tcgccgcggt cgaagtcacg gaagtctttg 3171901 tttgtgaacg tgttggaaat ctggatggcg cggtccggtc tgaaattata gaaaatcaca 3171961 gaatcgccgt cttggatttt cgcaacaggc tcaccgtttt cttttgtgat gacagatgga 3172021 atcacgaatt catcgtagat accatttgca tatgaatcat caacaacatc cagggcgctg 3172081 cggtaagatg ggccttcgcc gtacgccatt gcgcggtacg ctttttctac acggtcccag 3172141 cgtttgtcgc ggtccataga gtagtaacgt ccggaaatgc tggcgatttc acctacaccg 3172201 atttccttga tttgatcgtt caactggttg atgtacgttt tcgctgtctg cggacctaca 3172261 tcacggccgt caaggaagcc atggatataa acctttgtca gcccttcttt tttcgcaagc 3172321 tttaacagtg cgaataaatg attgatatgg ctgtgcacgc ctccgtcaga taaaagaccg 3172381 aacaggtgca aggctttgtt gttttctttc gcgttgctga tcgcgtcaag gaatgtttga 3172441 ttgcgttcga actctccttc acgaatggca acatttacgc gtgttaagct ttggtacaca 3172501 atacgtcccg caccgatatt taagtgacct acttcggagt tccccatttg cccttcagga 3172561 agacctacag cctcgcctga agcagtcaaa gtttgatgag gatactggtt ccaatagcgg 3172621 tcaaaattcg gttttttcgc taaagcgact gcgttcccta ctgtttcgtt acgtaatccg 3172681 aacccatcaa gaatgatgag tgcagctggt tttttactca tattgacctt cctccaataa 3172741 ttgaacgaat gactgtggct caaggctcgc gccgccgacc aaagcaccgt caatatcgga 3172801 ctctgccata tattctttaa tgtttgcagg ctttacgctt ccgccatatt ggatgcgaag 3172861 cttgtctgca gcttcttggc tgaagctttc agcgacggtt ttacggatat gcgcacacac 3172921 gtcattcgca tctttcgctg tagaagattt gcctgttccg attgcccaga ttggctcata 3172981 cgcaataaca gaagcagcaa cttgttcttc agaaagacca gcaaggcctt ttttcacttg 3173041 gtcagcaaca agatcatttg ttttgccggc ttcacgctct tcaagcgttt cacctacaca 3173101 gatgatcggc acaatgccgt gtttgaaagc tgcgtgtgct tttttgttaa ctgtttcatc 3173161 agtttcagcg aacatttcac ggcgctcaga gtggccgatg acgcagtagt caacgccaag 3173221 gtctttcaga gcaaccgggc tgatttcgcc tgtgaacgcg ccgctttctt cgaagtgcat 3173281 gttttgagcg ccgactttta ggtcagtgcc tttcacagca gaagcaagct tttctaagaa 3173341 aagcgctggc gcgcaaacaa cagcttcagc tttgtctgct gctggaatgg aagatttcac 3173401 ttcttcaacg aagctgacag cttcgccgag tgttttgttc attttccagt taccggcgat 3173461 aattggtttt ctcatctgtt ccacttcctt atagcagttt tgagattatt tatcgttcag 3173521 tgcagctacc cctggaagct ctttgccttc cataaactca agggatgcgc cgccgcctgt 3173581 tgagatgtgg ctcattttgt cagcaaggcc gaatttttca accgctgccg cagagtctcc 3173641 tccgccgatg acagagtatg tatctttcgc ctctgccaat gcttccgcaa ccgcttttgt 3173701 tccttgagcg aacaagtcga tttcgaatac gcccattggt ccgttccaca cgacaagttt 3173761 gctgtttttg atgacgtcag catacgtttc gcgtgttttc gtaccaatgt cgattgcttc 3173821 taaatcacta gggatttcag agatcggcac aattttcacg tttgcatcgt tagagaaatc 3173881 atctgcaacg agtacatctt caggcatgta gaagttaacg cctttttctt tagcgcggtc 3173941 cataaatgat ttcgcaagct cgattttatc ctcttcaaga agagatttcc cgacttcata 3174001 gccaagcgct tttacgaaag tataagcaag acctccgccg atgatcaggt tgtctacttt 3174061 atcaagaaga ctttcgatta caccgatttt gtcttttact ttcgctccgc cgatgatcgc 3174121 tgtgaacggg cggtcaggat tggaaaccgc ttttccaagt acatcaagct ctttttccat 3174181 taagaaacct gcaactgctg gcagatgctc ggcaattcca gctgtagatg cgtgagcacg 3174241 gtgggcagca ccgaatgcgt catttacata tacatctgca agctcagcaa atgcttttgc 3174301 aagctcagga tcatttttct cttcaccagg atagaaacgt acgttttcca atacaagaac 3174361 gtctccgtcc ttcatctcag aaatttgtgc ttttacagca tcgccgtatg cttcatccgc 3174421 ttttttcact tctttgccaa gcagttcgcc gagacgtgca gcgacaggag ttaaacgaag 3174481 ctcctcaacc acttcgcctt tcgggcggcc taagtggctc gcaagaagga cttttgcgcc 3174541 ttggtctgca aggtgtttga ttgttggaag cgcagcacgg atacgtgtat cgtctgttac 3174601 ttccccgtct ttcattggaa cgttaaagtc aacgcggcag aatacaactt tgccttttac 3174661 gtcgatgtct ttgagagttt ttttattcat gcctaggaga tcctccttca aaatggtttg 3174721 catacagcac gaaaaacgtg aaaccgtctg ttcaagcgat aactccgcta gggcagatcg 3174781 cagtcttttt cggcacaggg cagttcgtct aaaagccagg gcagcggcct taggcgaaag 3174841 cgccggcaaa gctgcttaaa acgcggtcgt ttctctatca cagagcgttt tctgaaagcc 3174901 ggtcttcatg gaaaaaggga aagggagtcc gtccccttcc cttgtccgct ttcattatag 3174961 cgcttctatt cgaaagaacc aagtcaggtc ctttttcagc tataaattaa agaccttttt 3175021 ttgcgatgta agctgcaagg tcaacaacgc ggttagagta gccgctttcg ttatcgtacc 3175081 aagagattac ttttaccatg ctgccttcca taaccattgt agaaagagca tcgattgtag 3175141 aagagttttt gtttccgttg tagtcgccag aaactaatgg ctcttcgctg tagccaagga 3175201 ttcctttaag gtcgccttca gccgcttctt taagagctgc gtttacttct tcagctgtta 3175261 cttcttggtt cagttcagca accaagtcaa ctagagaaac gtttggagtt ggaacacgca 3175321 ttgctccacc gttcagtttg ccttttagtt caggaagaac tagagaaact gctttagcag 3175381 caccagttga tgttgggatg atgttttcag ctgctgcacg cgcacgacgg tagtctttgt 3175441 gcggaagatc aaggatttgc tgatcgtttg tgtaagagtg aacagttgtc atcataccgc 3175501 gtttgatgcc gaatttatcg ttaagtactt ttgcaaacgg cgcaaggcag tttgttgtgc 3175561 aagatgcgtt agagataaca tcgtggttag ccgcatcgta tttatcttcg ttaacaccca 3175621 taacgattgt gatatcttct tcgttagcag gagcagagat gattactttt ttcgcgccag 3175681 cttctaagtg tttcgcagcg tctgcgcgtt ttgtgaagaa accagtagat tcaactacga 3175741 tttcaacgcc ttgtttgccc cagctaagtt tagcaggatc gcgttctgca gaaacttcaa 3175801 ttgttttgcc gttaacaaca aggttgttac cgtcaactga aacttcagcg tctaattttc 3175861 cgtgtacaga atcatattgt aaaaggtgag ccagcatgtt agcatctgtt aaatcgttaa 3175921 ccgctactac ctcaacttca ggattgttta atgctgcgcg gaatacgtta cgtccaatac 3175981 gaccaaaacc gttaataccg acttttactg ccatgattgt ttcctccttt aaataagtga 3176041 gagatattta tattgaggga ttattcatcc cttaataact tctttgcggc tccttcgtct 3176101 gtgacgagaa ccgtgttgcg tggcttttta aagtaagcct cgatcgcttc ggcttttgat 3176161 gatccgcccg ctaccgcaat aatatcgggg atggcgtcta tgtcatccag ctgcattccg 3176221 acagaatgca ctttgtgaac cacttcgccg tccgcgttaa aatagtagcc gaacgcttcc 3176281 gtcaccgcgt cgttatcatc tattttcttt aaatcttcta aaggcgtgtt tctgcgctga 3176341 gccatagttt tagcttcgcc gattccgtga accagcatac tcgctgattt aatggtgttc 3176401 agcacctctt tgacagaagg ctcttcaata atagatgaat aggcgccttg tgacagctgt 3176461 cccggaacaa acaaaagccg gtaagtgcct gaagccttct ccgccatatg cgcgcatatg 3176521 gtgttcgcct ggtttttcac gtcttcgcct aaaccgcctc ttgcaggcac aaacaaaagc 3176581 tcgcggtttt tagaatccgg cgtcatcatt tcggcgacag cttcaattgt cgtaccgcca 3176641 gttacagcga cgatattttt gcctgaaaat ctttttttca tacatgcgac agccgctctt 3176701 cccatttctt ttttgaccca tggggattga tcgctgtctc cggatacgat aatggcatcc 3176761 tttagattta aacgttcttt taatgtcttt tccaaaagag tcaaacctaa aacatctttc 3176821 atcgtatctt ccaaaacaga aagcagttca tagccctctt ctgtcaatgt catgccgttt 3176881 gtcttaatat cgaccaggtt ctgttccttt aaaaactgaa cctcgcccct cagcacacgc 3176941 tcgctgattc cgagactggc agacaggctt cttcgcccga tgggttctgt cagcctgata 3177001 tactgcaaga tttcaaacct cttttgcata acgagcagaa gatcaggcaa taattttttt 3177061 tgagcttgta ttaactggtt catgactcaa acgttccttc cttttttgct ggacattata 3177121 tgtcccgcta tgacaaaaaa cgtcccgtca tagccaaaaa aaatcatttc tgctttcttt 3177181 aattatttta acagggtgga attgtttatt caactgttaa gagccaattc atcgacaata 3177241 ttcgcagagt tttcatgccg cgtcgtttta tccagcaata ttttatccta tatatcttta 3177301 tcttatacag aaagcgccaa atggtgcatc ccaatataaa cagcccttcc cgtagaaagg 3177361 gctgtttcat taaagcgttt tcattttatc caaagctttt caatttcctc gagcgatttg 3177421 ttcttcgttt ctggacagat cgtaacgaca aacaggaaac aaaggatgtt aatcaccgca 3177481 aagatccaaa atgtataggc gagcccgaaa gaatcgatca tcattggcac aaactgtccg 3177541 atcgcccagt ttgctcccca taaaaagatg gtcgcaatgc ccgcggcccg cgcacgcaga 3177601 tggttcggga agatttcaga aatcataatc catgtgatcg gtccgaccga gacacagaaa 3177661 gcagcgacaa aacctaatat aaggacgatc atcatgatcc cgcttgttaa ctcaaaataa 3177721 aacgacgtcc cgattaaaat cataaaaata gccataaaag cagaaccgat ggacatcagt 3177781 ttttttcgtc cgactttatc aatcagcaac accgcaataa cggtaaaaat aacttctaca 3177841 accccgacga tacaagtcgt cacaaatccg gcgttttgcc cgaatcccat cattttaaag 3177901 atttccggcc cgtagtaagt aatcgcgttc atgccgatga cttggttaaa cagcgccagc 3177961 aggattccaa tgacaagcgc ctttctgaga cccggcttaa acagctggga gagcgacccc 3178021 atttgttcta tttttaaaga gttctcaatg ttctttaatt cttcttttgc aacagtttct 3178081 ccattaatac gtgtcaggat ctttaaagct tcatttgttt tgcccgcttt cgccagccat 3178141 ctcggacttt ccgggacgac gagcaggaca aggaaaaaaa tgacggatgg caccattcca 3178201 taagcaagca tccatctcca gccggtgtgc acgccccatt cgtatgttcc ggaccgctgc 3178261 acagctagat taataaagta tgttgcggaa atacccagta tcgtaaagag ctgatataac 3178321 gaagataaac ttccgcgtat agcgggcggt gccgcttctg taatatacgt aacagagagc 3178381 gatgagccca tcccgattcc cagccccccg ataatccttg caatgattaa ggtggacacg 3178441 tcttgagaaa gcgctgaaac gattgctgat atcgcaaata acaaagcggc tgtcattaaa 3178501 atttttctcc ggccgaatct gtcacttaaa aatccggata tcccgacgcc cacaactcct 3178561 ccaatcataa tgcttgaaat gacaagtccc tccataaacg gactcaggct gtataaatct 3178621 ttcagaaaac cgatggcgcc agaaatcact gccgtgtcat agccatacaa taagccgcca 3178681 agccccgccg cacatgagat caaaatgaca aatcccattg aatggcttct tgttacagga 3178741 acatttggtt ctaattgagt tggagtattc ttcatttccc tgccctcccg aatgttgagt 3178801 aaagcgtttt catttaaacc ttcaattgta cgtacttata ttaaaattta acgaaaatta 3178861 catttaatta gtacgtacaa atatagaata atcttgtttg cattttctgt caatgttttc 3178921 ttacaaagaa cgctgtgata tactgaaatt tgtccgtata cattttggag gaatggatat 3178981 gttaccaaaa tacgcgcaag taaaagaaga aatcagttct tggattaatc aaggcaaaat 3179041 actgcccgat caaaaaatcc ctaccgaaaa cgaattaatg cagcaattcg gcgtcagccg 3179101 gcataccatc cgcaaagcga tcggagacct cgtatcacaa ggtctgctgt acagcgtgca 3179161 aggcggaggc acctttgtcg cttcacgctc tgctaagtca gcgctgcatt ccaataaaac 3179221 gatcggtgtt ttgacaactt acatatcaga ctatattttc ccgagcatca tcagaggaat 3179281 cgagtcctat ttaagcgagc aggggtattc tatgcttttg acaagcacaa acaacaaccc 3179341 ggacaatgaa agaagaggct tagaaaacct gctgtcccag catattgacg gactcatcgt 3179401 agaaccgaca aaaagcgccc ttcaaacccc aaacatcggc tattatctga acttggagaa 3179461 aaacggcatt ccttttgcga tgattaacgc gtcatatgcc gagcttgccg cgccaagttt 3179521 taccttggat gatgtgaaag gcgggatgat ggcggcggag catttgcttt ctctcggcca 3179581 cacgcatatg atgggtattt ttaaagctga tgacacacaa ggcgtgaaac ggatgaacgg 3179641 atttatacag gcgcaccggg agcgtgagtt gtttccttct ccggatatga tcgtgacatt 3179701 tacaacggaa gaaaaagaat caaaacttct ggagaaagta aaagccacac tggagaaaaa 3179761 cagcaagcac atgccgacag ccattctttg ttataacgat gaaattgcgc tgaaggtgat 3179821 tgatatgctg agggagatgg atcttaaagt gccggaggat atgtctattg tcgggtacga 3179881 tgattcacat ttcgcccaaa tctcagaagt gaaactaacc tctgtcaaac atccgaaatc 3179941 agtgcttgga aaagcagccg ccaaatatgt cattgactgc ttagagcata aaaagccgaa 3180001 gcaagaggat gtcatatttg agcctgagtt gatcattcgc cagtccgcac gaaaactgaa 3180061 tgaataaaaa aagcaatgta tgggtctccc cgctacattg ctttttttat agctgttatc 3180121 tgtttttcca aacgtcagcg atgatttcaa acgaacgcat tctgtctgcg tgttcaaagg 3180181 tttctgagtt aaccataatt tcgtcagcct gtgtcgtttt gacgaaatct tcaagcttcg 3180241 ccttcacttc ttccggacct ccgacaatcg tggagctcag ctgctcattg accatcgctt 3180301 tttcatacgg gctccagatt tggtccatat cctcaacagg cggtttaagc tggttaggcg 3180361 taccgcggac aagatcaaga aacctttgat aatgggaagt cgcaaggtgc tgcgctttct 3180421 cgtttgtatc tgccgcgata atggtgacac cgaccatcgc atacggttcg tcgagcacgt 3180481 ctgacggcgt gaaggaattg cggtacagct ccaaagcggg aaccgtattc gccggtgaga 3180541 aatgggccgc gaacgcaaac ggaagaccaa gttcgccagc cagacgggcg ctgaagccgc 3180601 ttgagcccag cagccaaatc ggcacatcta tgccctctcc gggaatggcg cgaacttgat 3180661 tgcgcacatt tcctgacggt ttaaaataat tgcgcagttc ctctaattgt tctggaaaat 3180721 cctccccgct gttgatgttt ctgcggagcg ctctggctgt caattggtct gttcccggcg 3180781 cacgtccaag ccccagatca atccgcccgg gatacagtgt ttccagtgtg ccgaattgtt 3180841 cagcaatgac taatgaagag tggttgggga gcataatgcc gccggaaccg acgcggattt 3180901 tcttcgtgcc tccggcaata tggccaatca aaactgcggt ggcagagctt gcaacacctt 3180961 ctatattatg atgttcagca agccagtaac ggtgatagcc ccattcctct gcccggcgcg 3181021 ccaagtccat gctgtttcgg aatgattctg caatcgttcc tccctgaaca accggagata 3181081 aattcaagac agaaagcaag gtatctttgc gttggttgtt agacatattg ttctcctttg 3181141 caaatgtgtt atcagtaaac agcccaaagc tgtcaggtca tgattgaaag aacttctatc 3181201 acaccataac acaactgcat tcaggaataa aagaatttga ttcgatgaaa ttcgaacaat 3181261 ataaaacgaa cggtttggaa cattattctg ctccaaacaa ctccttagcc atctcaataa 3181321 agagcttagc cgccagagaa gcctccttta gcgacggaac agcaagctgc acatcacggt 3181381 atacctgcgg gtccaattcc ctggtcacca catgctctgg cagcggcatc cccgacatgg 3181441 acatttctga taaaatggcc aggcccaggc cttctctgat catactgatc gaggtgttga 3181501 tgttatagac cgtgaaagct gggtgcagcg tagcacccgc ctgcctgaac atatcgataa 3181561 atggtgattc atagccgccg tcacagacga tcatcggttc atggtcaaga tctttcagcg 3181621 taatggctga atgactggca agcgggtgat cgtccctgag cacgacagcc attttgtctt 3181681 ttttcaaatg aatgtactcc atctcctctg ttggatacag aagaatccca acatctatca 3181741 tccgcgtatg aagccactcc ttgacttcat ttacagttcc ctcgtgcagc acgagctcaa 3181801 gtttcggata tttttgttta aattcactga tcagcttcgg cataaaataa gccgaggcag 3181861 ttgagaatgt gccgatatgg atcgttccca gttcaagccc tttttccgct gctgctacct 3181921 gctcaacttt ttcaatgcct tttaagactt ctctgatgtg tactaagatc tgttttcccg 3181981 tatccgtcag catcaggcca ttgcggcggt cacgaatgat cagctttaca tcaagctcag 3182041 cttcgatcgc agaaatcgca tggctgacag ccggctgtgt catgttcagc gcctgacccg 3182101 cttttgtaaa gcttcccgtt tcagctattt tcacaaaaac ctttaattga gtaatggtca 3182161 taacaattta cttatgctcc ttataaaaaa gattcatttt atttatctta tgttctaccg 3182221 tatcatatga tggaaaagtt ctacaaggag tgaatgaaca atgaagcagc tcccaaaaac 3182281 gcggacagct ctcctgctcg catttctcgt catcatgtgg ggcgtcaatt ggccgctgtc 3182341 caaagccgcg ctcgcctatt ctccgccatt attgttcgcg ggcatccgaa cgctgatcgg 3182401 cgggctttta ttagtcatag tcgcactgcc gcgtattcat aaattacgct taaaagaaac 3182461 gtggccgatt tatcttgttt ctgctctttt aaatattaca ttattctacg gcctgcaaac 3182521 gatcgggctg aattatcttc cggccggcct gttttctgca atcgtcttct tccagcctgt 3182581 tctgatgggt gtattttctt ggctgtggct cggcgaatcc atgtttgtaa tgaaagtgat 3182641 tggcctcatc ctcggttttg cgggagtagc cgtcattagt gctgcgggct ttggcgggca 3182701 tatttctgtc attggggttc tgctggctct cggctccgca gtcagctggg cgctcgggac 3182761 agtatatatg aaaaaaacag gcagccgcgt cgattccatc tggatggtcg ctctgcagct 3182821 gacgatcgga agcgtgtttc tgcttatctc cggcttttgg acagaaagct tttcggcgat 3182881 ccaatggaca gctccgttta ttacgagcct gctgttcatc tccgtattcg ttatcgcact 3182941 cggctggctt gtctttttta cgcttgtcgg ttcaggagaa gcaagcaagg tcgcatctta 3183001 tacttttttg attccgctca tatcaatcgt ggccagctcc attttcctgc atgaaccgct 3183061 cacccttagc ctcttggcag ggctgctgct gattgtcacg agcatctgtc tcgtgaatac 3183121 aaaatcaaaa gcgcagaaag ctgcggcgat tggtataaac gagaaagctg cacaataata 3183181 aaaaccctct tgccggatgc ggcaagaggg tttcttattt actgatgctt gcgtcctttg 3183241 accaaatatg caactgtaat caaaaggtag atcgccgcag taatgccggt aatgacaatt 3183301 gatgttgtca tgatgacccc gatcagaatg gcgagtaatg ccacaatcgc aaaccatgtc 3183361 gtgtacggga accattttac ataataggcc ggtgtttccg tttgctgttt tctcgatttt 3183421 aaatgagcga atccgatgat cagccaaatg aataaaacgg tatatcccaa tgatcccatt 3183481 aaataattaa atgtttggct tcctgcgaac agagaaatca atacgccaat atagagagaa 3183541 gaagtgcaca tcagaatcgc aaacatcggt acgtttttcg atgaaagctt cgagaagacc 3183601 tttggaagcc ttccgtcact tgcctgtgta tacaaaatgc gtgatgatcc gtataaacct 3183661 gaattcatag aagaaatgat cgccagcagg atgactgcat tcatgatatg atccgcgccc 3183721 ggaatgccta ccattttaaa gaccatcacg aaaggacttt ccggaacgga attgacttgg 3183781 ttccatggaa tcaggctgac gatgatgaaa aacggcagca ggtaaaacgc gacaatccgt 3183841 gtcagtgtgc tgcggacagc tttcgggaca accttttccg gattttttgt ctctgcaagc 3183901 gttacaccga taatttctgt accgccgtaa gagtagatga cgacaagcat cgccgtgatc 3183961 agccctgtgc cgccgtgcgg gaaaaatccg ccgtggtctg tcaggttgga aaatccggat 3184021 gctgtatgat caccgaatga tacaaataag agcagcaatc ccagaataat aaagataata 3184081 ataacggtaa tcttgatcat tgccagccaa tattcagttt cggcgaagat tttaacagaa 3184141 agcaagttta caatcgtgac gataagagaa attcctaatg ccaacaccca gatcgggcag 3184201 cccggcagcc aatattgaat gaaaatcgca gctacaacag cttcagccgc aatgttaagc 3184261 acccacattt tccagtagat ccagtccaaa aagtaagcag cgtaatttcc caatacctgc 3184321 tggacaagat cacggaaggt tctggcgtta cggtttcgaa cagccatttc cgccagcccc 3184381 tgcataataa acagcaaaat aatcccgccg agcaggtatg cgataatgac agatggccct 3184441 gccacatcga tcgctgagct gctcccctta aataaacctg cgccgattgc tccgcccagc 3184501 gccatcatca taatatggcg ggacgtcatc gtgcgtttta acgtttgatt gtcgtttttc 3184561 atcctcttct acctctcctt ctcgttttca aaaacaaaaa agcccgccgt ctcctaccta 3184621 atctaataga taaagagacg acgagccttc ggctgaccgc ggtaccactc ttgttgattc 3184681 ttcatgaaga atcctgcttt tgacctgtaa cgaaggttag ccgttaaaac atagggaata 3184741 ttcaatctat tccgttccgt cttaccactc ccgggcgagt tcaaagaaga atcaggctgc 3184801 gtcgcaccac cccgcagctc tctgttctga tcactttctt ttactgctcc caatctatgt 3184861 gttttagttt tctgaaaaac tcaaatttta tgatctgaat atattaacat aatatacgtg 3184921 cttctctttt aactgtcaat aacttcagag aaaaaagaaa ctgttatttt gtcccttttc 3184981 gaatggcttt ccaaaaggat tctgactcgt ttcctaatgc gtaaactgaa acacctgcta 3185041 ttttatattg ctttgccaga tggcttttcg tttgaacggt tttttcgttt tcataccaca 3185101 cgacatgttt atgcttcttt ttgtcaacat aagaaaacgt catcgagcct gattttttgt 3185161 tgaatgccgg ctttgctttt tgttttttga tgagggattt gagctcattc cattccctta 3185221 ttgtgctggt acttccgtct tttacatccc agtcatagcc gtacgcaggg attcccatga 3185281 tgactttatt ggctttgatc tttttgactg aaaactgcag agagcttttg atccagtttg 3185341 tgcttgccac tgaccccggc tcaccccaaa tgccgtgttc atcgtaggtc atgacttgta 3185401 cgaagtcggc atatttgccg attttcgcat aatcatacgg ccagctccag tcatcatttt 3185461 tatcatcggc gcttttggcc ggaacggata ccattgtttt aatatgtttc ttattcaaag 3185521 cctgtgagac atattgaatg aagttcgagt atgcagcgcg gtcttctgga tttactgctt 3185581 caaaatcgat attgattccg taatatgagt gctttttggc cagtgtaatt aactgatctg 3185641 tgaatcgttt tttcgctgtt ttattgctca tgacccgact cgctaaatct ccgtcaaaat 3185701 cataaatggc atcattatag tttgaaatga cagcccatgt cttgattttt ttctttttcg 3185761 catatgtcag ctgcttagtt ggggcatcgc caatgatttg tccgtttttt tcaaacgcaa 3185821 atgtatcggt tgcgatggca ttcatgtatg tatgatattt cgtaagagaa ttgtatgaag 3185881 ccgtatcccc agtcgtgtag cctactgtca taccggctgc cttcgcttct ccttttgtat 3185941 acataaacag aacaatcgca atcgccagtg aaaccgctat gatcagccat tttttcatcg 3186001 catttcctcc tgtatcaagt catactcttc tcatcggcca aaaaattgga agttgaagtt 3186061 ttttcaagca aaaagcccgg catatgcctg ccgggcttcc tgagttcagc ggtcagagac 3186121 gagaatatat gctgccttta ctggtccatg cacccccaca actaaatcca tttcaatgtc 3186181 ggctgagtta ctcggtccgg taatgtagtt gatacatgaa ggaacagtga caccgttcgc 3186241 aatgttttgg cggatgatat cactggcttg tgtcattctc ggtacaatgc ttgatttcgg 3186301 cacgatcgca atataagtcg ttggcaaaag gctgacagag cggccgatgt cttttgagga 3186361 gaagaggaca accgtccccg actcagccaa tgtaatttcg ctgaatgtaa tccctacatt 3186421 ggcttgctcc gcttttttaa tattttcctc gcctttgtca gcatcccact cccagaccgg 3186481 cgttccttca ctcggccagt ccttggtgag caggcttttc agtccgtatt cttcaaagcg 3186541 ggggtccttc ggaatgatga cagggcctcc agaaaagcgg ctgacttgct cgcgcagggc 3186601 atcgtaaagg ccggttgaat ccgtttcaat cagctctgta tggattttga cacaatggtt 3186661 tttgagcact gtgactaagt catccgctga ataaccttca agtgttttat attgcggctg 3186721 atgcgcccat tcagggactg ccacgcctcc tgttcttcgt tcacggccca ggctggatgc 3186781 gattcggttt aaaaagctct cttgattctg aatggttccc ttcgtcatca ctgctcctcc 3186841 ttcgtgcgtt cacttgtttc tctgtccgca aaccagtctc tgaatctcga tttatgcggt 3186901 gccgggaagt cgcgaatctg ggtccaattt ttaagcgggc cgggcccttt cgaaattttt 3186961 tcgtcctctg taaaaggcgt catggcggcc ggcgcccatt ttgagcccat tttgtaaagc 3187021 gataaggagg atgcgccaag tccgaatgct ttcattgcaa gcttttcact gatcggcgcc 3187081 ctgccttctt tttcgacgat attctgacga tgcttgagta gcagctcatg aagcgggatt 3187141 ttgaccgggc aggcttctga acaagcagcg cacagtgaag atgcgtacgg cagctcctta 3187201 taatcgtcat aaccgccgag caacggtgat aaaacagctc cgatcggccc cgagtagatt 3187261 gagccgtatg aatgtccgcc gacatggcgg tacacaggac agacattgat acaggcggca 3187321 cagcggatac attgcagcac agactggaat tccgttccaa ggatattgga tcgtccatta 3187381 tcaacgatga caagatggaa ttcttccgga ccgtccactt caccttccag cttcggaccc 3187441 gtcaaagctg taatatagct tgtcagccgc tgtccgacag cacttctagt cagcatgctg 3187501 actagcactt caaattcaga aaatgacggg acaatccgct ccattcccat gacggtaatt 3187561 tgtgttttcg gcaaggtgct cacaagccgt ccatttcctt cattggtcac aaggctgacg 3187621 gaacccgtgt cagcgatggc gaagttacag ccggtaatgc cgatatccgc ttccagaaac 3187681 tttttccgga gaatggcgcg cgcatgcatc accagctctt ccggtttttc tgtatgttga 3187741 tagtccagtc tttctttaaa cacatcgcgt atctgctctt tatttttatg aagagcgggc 3187801 gctacgatat gtgacggcgg atcgtgatca tcaatctgca aaatatactc gccgagatcg 3187861 gtttctacga cttcacagcc ttccttctcc agcacctcat tcagattgat ttcctctgtg 3187921 accattgatt tagatttcac aattttcttc ccgttcttct tttgaatgac atcccgaata 3187981 taggaagacg cctcttccgc tgttttcgcg aaatagacat gtccgcctct tttcgccaca 3188041 ttttcggcaa gctgtccgag atagaaatca aggttttcaa ggacatgctg cctgatttcc 3188101 tctgataatg agcgccactc ctcccagttt cccagttctt ctgctgcctc taggcgccgc 3188161 gtccgcagac gctcctgtgc acctgaaaca gcgcctctca taaattcatt atcaatcccc 3188221 tgtgataccc gctctttaaa agcgtcagta ccgattttca tcgccatgat cctttccccc 3188281 tctgaatcca gttttatctg ctgttgagca cttcggcgat gtgcatcact ttgacattct 3188341 tatcttttcg gccaagccgt cccccgatat tcatcaaaca gccgcagtca gcaccgatca 3188401 gcacctctgc tcccgtttcc tccacacatt cgactttttc atcgaccatc tgctcagaaa 3188461 tctgcgccat cttgactgag aacgttcctc cgaatccgca gcagttatgt ttgcccggaa 3188521 gctctgtaaa ctgcaggccc ttcacatggc tcaacagctt catcggctcc ttccgaacac 3188581 ccagcagcct agtcatatgg cacgacgtat gtaaggtcgc ttttgtatga agggtcgcgc 3188641 cgacatcctc taccccaagg acgttcacaa taaaatctgt cagttcatac gttttatccg 3188701 ccagcttttt cgctttatcg gcccatttcg gatcatcctg aaacaggtgc ggatactccc 3188761 ggaacatcgt tgtgcaggaa cccgaaggac tgacaacata ttcggaatcc tgaaacgttt 3188821 cgatcatccg tttcattgct tttttggcgt catgtacata gccgctgttg taagccggct 3188881 gtccgcagca aatctgccct tctggaaaat caacctcgca cccaagccgc tccagcagct 3188941 caaccgttgc ttttccgaca tttgtttgaa acatatcaac aagacaagtg acaaaaagtg 3189001 agactttcat gatgaacccc tctctcatcc ccaatatatg atcaggtcat ctgatgacct 3189061 gagttaaaat aactatatga atatcgtaca ctattctgac aatggaagga aagagttttc 3189121 tagggatatt ttcatttgtg gcatatcaaa aacactcccg atctcccagg agtgcagtat 3189181 atggttagat ccagcccttt tcctcagcga tgctggcggc ttctgtccga tttttcgcat 3189241 taagcttttg gatgatttct gagatatagt ttcgaactgt gccttgagat aaatagagct 3189301 ccagcgtaat gtcttttgtt gtcttgccta aagccgcaag cctcagaatt tcttgctctc 3189361 taacggttag cggattttcg tctcgcatca tattaaacgt cagctcaggg ctgaagacac 3189421 gttttccctt tacacatttt cgaatggcat cggccagatc gtcaatttca ccgtctttca 3189481 gcagatagcc atgtgcaccg gcctttacgg cgcgttcaaa atatccgggg cgggcaaagg 3189541 tggttaaaat aatgaccttg ctgacgcagc cttttttcat taattcctct gccacattca 3189601 gcccgcttcg aaccggcatt tcaatgtcca taatgcatac atccggctcc agcttcaaaa 3189661 tagcatgtag cgcctcttcc ccgtttaatg cttgtccgat gactgtcata tcctcttcta 3189721 aatcaagcaa agatcccaaa gcgcctaaaa gcattcgctg gtcctcagca ataaacagac 3189781 gaatcattct tttcgtcctc caatcattct gcttttttaa taagcggaat cgtcagtgcc 3189841 acaaccgttc cgttatggtc tgaaaccgtt aatccccctt caatgagcat gagccgttct 3189901 tccattcccc acaggccatt cccaaacatt ttctccttcg gcgctccctt tccgtcatcc 3189961 cgtattacga tcctcatttt gtcagcaaat tgagaaatgg tgatggcaca gtgggttgct 3190021 ttgctgtgct tgataatgtt agtcacggct tcccgcatac acatactgat aatattttga 3190081 gtgacgggag atatcactga aaagtcgtcg gctccttcgt attgaaaggt aatgttcccc 3190141 gctcttaata tgtgctgaat gtttacgagc tcctctgtta tcgtgaccgt tctcatatca 3190201 gaaaccagct ctcgaacttg cttgagtgcg gagcgtgaac tggtttccat ttcttttgcc 3190261 tcaagcttgg tccgttctgg atcagatgca gccagccgct gaatgagctg gctttttaat 3190321 gtaagcagcg acagggtgtg gccaagagta tcgtgaagat cacgggcgat tcgaacacgt 3190381 tcctcccttt tagagagttc ttttatctgt tcgttggctt gtgcaagctt agcttcaagc 3190441 tcaatcctcc gaaacataga acgaattccg aatggagaaa tgagcataat gacgagaaac 3190501 gggagaacag aaaaaagctc ccgaagcgag accgaattcg cgataaattg gtataggcat 3190561 ggaaaaagca gtataaagat taaagcgcag aacgcacggt taaaattcgt tttctctttg 3190621 taataaccaa caaagtttgc cggaaaaaaa cctaagtata tataggtgat attgtaaaac 3190681 acactataca tcaaaataac cgccatttgc acgataagcc aatatgtaaa cgaagctttg 3190741 cccacgctgc agaataactg gcgatatgcc gctacaaaaa ggagcagcat accatatccg 3190801 atcccctgtt tgacccctga ttcttttaat aaagagagga acggcataat cgtatacacc 3190861 agaaagatat aagggaaaaa cccgaattcc ttcgggaaaa tagatattgc ctttttcatg 3190921 tattacaccg cttcttgttt tcttcttata tatttagata gtagcatgaa gagcatcata 3190981 taagcgatta atatcagaat atttttccaa gtcggactcc caccccggac aagttcccac 3191041 gctccgctcc cgaaatgata agacggaagc cactggccaa tgctctgcat catgtcaggc 3191101 atgacctcaa acggcatcca catccctccg cctaaagcca gcagcatata aagcacatta 3191161 ctgattccgg ccgctgtttc tacttttctc atgaggccga ttagtgtgcc taatgctaaa 3191221 aaaggcaatg cgccaaacaa aatccacagt ccgctcatca tccattcaaa cggtgacaag 3191281 gcaatatcat tgatgattgc gccgaacaga aatatgacgg taattgataa aacgtgaatg 3191341 acactttggc cgatcatctg agctgataaa tagatatgat ccggaagagg cgtaaggcgg 3191401 ataaaggcgg cccagccttg tgaccgttct tgtaccattc ggatgccaag cgtcatgata 3191461 gaggaaccca tcacgctgaa gactgtcatc gacatcaggt aatgggcttc ccatgcacgt 3191521 tgatcaggga cgttggtatt cactacattt gtaaagaaat aataaaaggc aatcggcatg 3191581 atcagagacc aaagcacaaa gtacttgttc ctaagcaccc ttttcatttc agcgatgctt 3191641 tgcttttgca gcacgttcac tcacatcgcc tccctgttgc cgtcagccag ctggcgaaat 3191701 gcctcatcga gcgttgcttg ctcaattcga atatcccgtg catgtatgtt ttcttgaaag 3191761 atcagcgcca acactttgtc tgtatttgat gtctggatga tggttctctc atgctcgtgg 3191821 atcactctct cgacttccgg gtgacaagac agcctttcca atgattcact tgaatgaagc 3191881 gtaaaggaaa cagactgttt ttgaattctt gagcggattt gcattggtga gccgtctgca 3191941 acaagctgtc cttcagtaaa aaataggatt cgctgtgcgg catcatctgc ttcctgtaaa 3192001 taatgagttg aaaaaataat cgtttttcct tggtccgaca gtccgtgaat ggtctgccag 3192061 aatcggtgtc ttgatgaagt gtccatgccg actgtcggtt catcaagtat aagcagctcc 3192121 gggttcccgg caagagccaa agcaaagctc aaacggcgtt tttgtccgcc ggataatttt 3192181 tctgctcttg ttttcaaatc ttctttggtg agtgctgtta acgaaacgag ttctttcatg 3192241 gacaatggat tcggataata gctccggaag agttcaagga tttcatccac cttaaggccc 3192301 ggcatgacac ttacttcctg aagcattaca cctatttttt cacgaacctg ttgatcatcg 3192361 ggaacccggt taaatagttt gatttctccc tcactcggtt tcagcaatcc taatatcatc 3192421 gagacgacgg tcgtcttccc tgccccattt ggcccgagaa tggctgcaat ttctcctttt 3192481 tcaatactga agctgatgtt gtttacagcg gtttttcgct ggaaatgttt tgtcacgttg 3192541 cttactgtta ctgcttcttt catcacatga gcacctcctg atcgtttaca ttgattgtaa 3192601 aatgacggag aagacgatgt tagtatgggg tgtcatgatg atggagtgac aaatgtcatt 3192661 tttttctcac cccggtgtct aggcaatcct cctcctgcat cttccaattc atccatcttt 3192721 tctatctccc atgtcctctt tcttttaaac tgctgtgaca ttcatagaaa gatacactct 3192781 tcaaaccatc cgagtgttat gatagaaata ttgaacttta tattactttc cggctgaaag 3192841 gagccaatca tgaacgaagc gattttgtct agaaatcatg tgaaggtgaa aggcagcggc 3192901 aaagcatcta tcatgttcgc acctggtttt ggatgcgatc aaagcgtgtg gaatgccgtg 3192961 gcacctgcct ttgaagaaga tcatcgggtg attttatttg attacgtcgg ttcgggacat 3193021 tcagatttgc gcgcatatga cctgaatcgt taccagacac ttgacggcta tgcccaggat 3193081 gttcttgatg tttgtgaagc tttagatctg aaggaaaccg tgtttgtggg tcactccgtc 3193141 ggggccttga ttgggatgct tgcatccatc cgccgcccgg agcttttttc ccatctggtg 3193201 atggtggggc cttctccttg ctatttgaat gatccgcctg agtattacgg aggatttgaa 3193261 gaggagcagc tccttggctt gctggagatg atggagaaaa attatatcgg ctgggcgact 3193321 gtatttgcgg caaccgttct gaatcagcca gatcggcctg aaattaagga agagcttgaa 3193381 agccgttttt gttctactga tcctgtcatt gcccgccaat tcgcgaaagc ggcgtttttt 3193441 tctgatcacc gagaggatct ttcgaaggta acggttccct ctcttattct ccaatgtgca 3193501 gatgatatca tcgcacctgc aacagtaggt aagtatatgc atcagcatct gccttatagc 3193561 agtctgaaac aaatggaggc tcgcggacat tgccctcata tgagccatcc agatgagacg 3193621 atacagctga tcggcgatta tttaaaagca cacgtgtgat ataggaacga aagggataga 3193681 ggtgaccctc ttagatggac aaacaattga atgatgcacc atgcggtttc ctcgctttgt 3193741 cagaagaggg gtcgatcata gctgccaacc gcacccttat caagattctg gattatgaac 3193801 cggagcaggt tatcggccag cacatgaata tgatgttgac cattcccgcg cagcttttct 3193861 gccagcttta tttttttccg cttttgaaat tggagcatca catcgaagaa atatacattt 3193921 ccctgaaagc aagagatgga gaagaaattc ccgtccttat caatgctatt gcgagacacg 3193981 atagcggggc ttctgtcttt gattgtgttc tgattccaat gcgaaagcga aatgaatatg 3194041 aaaatgagct gctgatagcc agaaatgagg ctcaggaagc tttgcttgcc aaacagaaag 3194101 ccaatgcgga gttagaaatt gccttggaaa cgctgaaagc aaaacaagaa gaacttcttg 3194161 agatcaataa acaaaatcaa caatttaaat taaacaccaa aagagagctt gaactcgcca 3194221 gaaagatcca gaaaaactcg ttgactgaac cgattgtaaa cgatcaggtt cagattgact 3194281 cttattacaa cgcatcgagt gaattgtcag gtgatcttta cggatattat caaatcgatg 3194341 aacaccgtta cggcattatt atccttgatg tgatggggca cggaatttca tctgcattga 3194401 ttacgatgtc tcttcatcct ttgttccagc gccagatcac gcaaggtctc agccccgtta 3194461 aagttatgaa ggaattggac cggcaccttc acagcttgtt tcaaaatgat gaggaagcaa 3194521 gacattattg cactgctatt tatctcgaga ttgatatagc acggcaaaga attgattatg 3194581 tcaacgcagg gcatccgccg gcactttggc aggacgatag cggaactcaa catctgcttc 3194641 acgcgacctc gcctccgatc gggatgtttg aagacttaga gtttcagtca agcagccttt 3194701 catacacgga ggacggaaga ttgcttctgt atacggatgg cgtgatggat cctacggctt 3194761 catgttattt atttgattta ctaaaggatc atcctgattc gccaatcgct gacctgaagg 3194821 agaaaatcct tacatcactg cagcatcaaa aggaagctca tcataagagt gatgacgaat 3194881 gttttatatt agttgatgta aaataaaatg atccatgaga cataacaatg atttgttaca 3194941 tctcatggat ttttttgttt cagcgtttct ttggaatatg tcctgactcc gcatattgaa 3195001 acacctgcaa ggaaggcagc gggtgtccat taaaatcaaa taaagcttga ttatctacag 3195061 cacttccccc ataccacttc ccggcgtctt cagggtcgta ttcagcagca tagctggacg 3195121 cccaccctga cccgtatgtt tcccataaca ctttgttttt ctctatctgt gtcttcggcc 3195181 cgactggaat ccacgccggc tcccagtaga aaacaccaag tcctgctttg cccgtattcg 3195241 ccactgcctc cattacatct cttactgcag ttgcctggcc ttgaacagaa attggatatg 3195301 gcaacgtctg cccgcttttt ggtgctgtat ttccatgccc atcgccatcc tcagcggtat 3195361 aggtgtacga tgtctccgcc accatgactt ttttgccgta cgtattggca acagccttca 3195421 gcacggaggt caaattttgt aatgtgccat gccagaaagg ataataggag ctagcaaaca 3195481 catcataatc cactttgttt ttgctgagtg tttctgcaat aaatgaatac cttccagccg 3195541 tttcaggatt ggtaaaatgc agggcgacca aaatatttga atttgtctcc ctgaccgctc 3195601 ggcttccttc attaaataat tggcacatct tcgtccaatc agtctcaccg gcaaatcctc 3195661 ctgttgtttc atttccgacc tgaaccatgc cgatgtcaac gccttccttg atcatctttt 3195721 gcaggctttg tttcgtatac tcatagagct ttgctttttt tgcttcaaag ctgagattcg 3195781 cccaggcttt gggcaccttt tgtttcgctg gatcggccca gaaatcagag tagtgaaagt 3195841 cggccagcac cttcattccg ttcgctgtcg ctctttttcc gatttcgatg gctttttgaa 3195901 catcattgtt tcccccgcca tacccgttgc catttgaatc atacgggtga ttccagatgc 3195961 ggacgcgaac atagttgacc ccagcctgtt ttaaagttgt aaagatatcc tggcgttttc 3196021 cgtttgtatt gtaaaaggtg acaccgctgt tttccaaagc aataacgctg gatacatctg 3196081 cccctttgat aaaatccttg ttcatcccct ctactttttt aacaaaaaga tcctctgccc 3196141 gaagctctga cacgtgcttc tccttctcaa tggcagcggc atatcctgtt gaactacatg 3196201 cactccacac gatggcagcc gcaaagaaca ttttcacttt gcttttcatg atttcatccc 3196261 cccaagactt agcaagcgtt ttcattctat agaaaaaaga atccgcccat atcgagcgga 3196321 gcatcagcct aatgtgtgtt tacgacaatt ctcacttcat acttttccat cgtcaggtcg 3196381 cctgacaata tgtctcctgt cattatgtcc ttcacactct gatcaaacgt gaccagctgt 3196441 ttttcttccg tgaaattcat gacaaaaata taatcattgt cctgatcctg cctcgcttgt 3196501 acggagacgc cttttccgtg ccgaaccgga aaaactggag agagagacag gtctgtgatc 3196561 agaccctcat agaaatcacg ctgaaattga tcctccaaac gcgcgccgat aaaatacgcc 3196621 ttgccctgct gatactcatg gcttgtgacc gctggcgtgc gcgcataaaa atcttcttga 3196681 tacaccgctt ccactgaagc tgtctttaca tcaatcacgg ttgcataatc cttcatttca 3196741 tatatttggc tgcggtagct gacagcgttt cgatccttcg gatacagggt gtccgtttca 3196801 agaggctcaa ctccaaatat agcttgaaga tccggatgcc atccgcctgt gtatgttaag 3196861 tcatgctcat tcacaacccc gctgatatac gtcatgacta aggtgccgcc gtcagccgta 3196921 aacgctttta aacgggaaac ggtgtcctcg ctgattaaat acagcatcgg gacgatcagc 3196981 agtttatatg gtgaaaagtc ttgttctttc gtgatgacgt cgacagggat atcgtgttcc 3197041 cagaatgtgc ggtaatgctg ctgaagcgtt tgcggataac gttttgtcgc cttcgcaaac 3197101 ccctgagcat cctcgagcgc ccaatgattt tcccagtcat ataaaatcgc ggtttgagcc 3197161 ggcctcttcg ttccgacaac ttcggacagc cgttccaatg tctcgcctac cttggccact 3197221 tcttgaaaga cgcggttctt cgggctattg tcatgatcca caaccgctcc gtgtaatttt 3197281 tctgatgacc cccgtgattt gcggtattgg aaatagagaa cgctgtccga gccgtgggca 3197341 atcatttgca tggatgacag cagattcatg cccgggcgct ttgccttgtt gacgttatgc 3197401 caattgaccg cgcttggcgt acactccatt aataagaagg gctgctgctt caagcttcgg 3197461 tacagatcat tgataaagcc gaccttcatc gccaaatcag ctgtgctttc ccagtcattg 3197521 tgccagacag gataagcgtc ccagctgatg gcatcgacat gctttgcaaa tttgctgtag 3197581 tcgaggccct gatacgggat caaatccggt gtgtcagcca taaaattcgt tgtgataggg 3197641 atatcaggcg tcaattcttt cagcggaatg atttcatttt cataaaacga aatcgtttga 3197701 tcggtgacga accggcgcca atctaaattc aggccatgca agccattttc accgatcggc 3197761 gaagggcttt caatttgtga ccagtcattg aacgtatggc tccaaaaagg ggtccaccac 3197821 gcatggttca atgtcttgag gctgttgtca tatttcgatt tcagccactc ccggaaagca 3197881 tgctggcata aatcacagtg gcaatctccc ccgtattcgt ttgaaatgtg ccacattaac 3197941 agcgccgggt gatgtccgta tcgttctgct aataagcggt tgatgtgccg tgttttttct 3198001 cggtagactt tagatgtgag gcagtggttg tgccttccgc cgtgcagctg tttgacgcgg 3198061 gaggcattga cgcgcaaaac ttccggatag gtttgcgaca gccaggccgg acgggctccg 3198121 ctcggcgttg ctaatatgac ccggccgcct atactgtgaa tccgctcaaa aatatcatcc 3198181 agccattcaa attgatatac gccctcctcc ggctcaagtg cgctccatgc aaaaatgccg 3198241 acagaaaacg tattcgtatg agaaagcttc atcagtttga tatcgtcagc taaaatatcg 3198301 ggccgatcca gccactgatc ggggttgtag tctcccccat ggagcataaa ttttgctttt 3198361 gttacgtgcg ttttttcaag ctttgacatc acattctcct ccttgttctc ttagcccttc 3198421 gttccgcctg cggttaatcc ggacacaaaa ttcttttgca gcataataaa gatgacggca 3198481 accggtatgc tgataagcag ggctccggcc gcaaatgtcg tatagctggc ccccatgaca 3198541 tcattcacta aattgaatag accgacgggc aatgtatatg attcaggcgt tctcaatatg 3198601 gttgaggaca gcacaaaatc tccgagcgga ccggtaaagc cgttcatggc cacgactgcc 3198661 gccatcggtt ttgataatgg cagaatgatc tggaagaaga ttctggtgct gctggctccg 3198721 tcaatcttgg cgctttcgtc taaatccatc ggaatggaat ccatgtaccc tttcatcaaa 3198781 tacgtattca tcgggatcag gccgccgata taaagcaaga ttagcagcca gtggctattg 3198841 atcattccca agatttgcgc cagcacaaac aaggcaatta aagctgaaaa ctgaggaatc 3198901 atctgcagca ataaaaagag cgttaaagcg tatttcctcc ctttaaaccg aaagcgcgaa 3198961 aacgcatagg ccgtaaacgt cacacagagc aaagaccctg ccattgtaaa caggctgatc 3199021 ttcatagagt tgacatacca ctgcacatat tgaaggcttt ccttgcccgc aaataattcc 3199081 ttgtaatgat cgaatgtcgg atgcttcgga atgatggatg tactgattaa gctgttgccg 3199141 ggattaaagc ttgcgcctgc cgtccaaagg agaggataaa caatgatgac cgccataaag 3199201 gctagcaaca agtaagagaa aaggagacgg atatatcttc tgactttcat atctgccagc 3199261 ataccttatg cctcctcttt aaaagacttt gtctgtctga actgccacaa tgcgatggag 3199321 ataacaaata cagataataa aatggttaaa gccgcagcaa gtgaatattg gctggactgc 3199381 attgtcaatt tataaatcca tgaaacgagg atatctgtcc cgccggctgt tgatccggtt 3199441 acagccggac ctccgccatt gaatagatag ataatattaa agttattaaa gttaaacgta 3199501 aactgagtaa tgataatcgg agccattgca atgaacacca tcggaagcgt gatgtatctc 3199561 agctttgaaa agacagaagc gccatcaatc gtagctgctt catacagatc gtccgggatg 3199621 gattgcaata cgcctgttga gacgagaaag atgtacggaa atccgagcca gccctgcatg 3199681 agaatcaatg caagcctcga ccaattggca tctgtcatcc acggaagcgg atctatcccg 3199741 aagaaagcca agatgtcgtg attcatcgca ccgaagctat cattaaacag tcccgcaaaa 3199801 attaaaatcg tcacaaaacc gggaacggcc catggcaaaa tcagaatcgt ccgaaaaaaa 3199861 cgtttaaacc gaaggtcttt ctggttaaca atgatcgcga gaaaaatccc caaggtgact 3199921 tgcagtgtgg atgcagcaag tgtccaaacc accgtccaag ccagtacatc aaaaaaagtc 3199981 gacctccaaa tatcaactgt gaaaatattt gcgaacgttt gaaaaccgac ccaatcaatt 3200041 aattttgcag gaggagaatg atacaaatca tagtttgtaa acgctaatgc aaagctgaat 3200101 aagataggaa agatcacggc gaaaattaaa ataaacaaag atgggccgct gacgacataa 3200161 ggatagccct cagaaatgat atgctggtat tgttccttta aggaacttaa tggcttattt 3200221 tcatcacgct gttttccgct ttggaacgca tcgcgaagat ttacataata caccgcaagg 3200281 ccaaagcagg tcacgatgac agcaataatc ccttccgcca gcagaaaaac ggaattatcc 3200341 cgcggcactt ctgttcccag tgtaaagatt ccccaaaacc ccatattgag cagatctcca 3200401 aagaccgcaa aaaacgatgc gcctaagaaa agaaagacaa taccttttat ccattgcttg 3200461 ttataaaatt gcccgagtcc cggaatgata gaaagcaaca aagcgacttg acgatgctgc 3200521 accgttttca cctctcttac aatacaaatc tagctttctc tttattttcc gctgtgcttt 3200581 gccttaattt gtcctttggc cgtttcagct gcttgatcca atgcttgttt cggatctgcc 3200641 ttccctgttg caaccgtctg taatgctgaa tcagccggcg tccatatttc attcatttcc 3200701 ggaatatttg gtgttggctc tgagaaacgg gattgttcag taacagcccg tgccgcctcg 3200761 cttttcataa tagccgggtc attggctagg gatttcacag caggaacttc tttcgtttct 3200821 tcatatcgtg ttttagaatt tttttcattt gccaggaaaa cggctaattc ttgcgccagc 3200881 tcttcattct ttgaaaatgc actgacgttg tagcttttga cgccgataaa ggagctcatg 3200941 tttttcccat tttccagctt cggcagtttc gtaatgccat aattgattcc tgcattcgaa 3201001 aaggcttcta cattccatgg accagaaata attgcggcgg cttttccttc tgtgaacagc 3201061 gattccaaca cgttaatccc ttgttctcca ataatgccag ccgggaacag gccatctttg 3201121 taaaacttct gaatcagcgc cgcacctttg acagctcctt cattattgat tccaatgtct 3201181 gacgggttat agctcccatc tttggccttt ccaaaaatgt atccgccata tccgctcatc 3201241 acactttctg cataataaat ttgatcgaat agggctaaaa agccaaattt gctgccgtca 3201301 gcagtctttt tggaatagtc gtaccactct tccagcgttt tgggcaattc cttttctgtg 3201361 atgagatctt tgttgtaaaa aagcacagtc gtttcgaccg cttttggcag tccataaagc 3201421 ttttgatcta ccatttgaga ctgaatggaa gcgtcagtat aaagtgattg aacgtctttt 3201481 ttgacatgta attccttgag taatccttcc gtgacagcgg ttccgatttg gtcccctggc 3201541 attgttaaca cgtcagggcc tgtgccggcc ggtccatcca ttcgcaaatc ttcaatctgc 3201601 ttggcatacg gtttttcaac gactttgacc ttcacatcat gctctttttc aaatgcagcc 3201661 acagcgtctt taatgccgtt gctcttttct ttatcctccc atacaacaag ctctgaccct 3201721 tttgaactcg atttggcgct gctgctttcc tttgggccgc aagccgccaa ggataaactg 3201781 acagctgcgc agagcatgaa tacggaacac ttttttgcca ttttcattga ttgtcaccct 3201841 ttcggtagga atgaaagcgc tttaaagata atatagcatg cctgagaaaa tgtgtaaaca 3201901 aactatttac ttcatagagt aaattttttt acctaaataa aaaatgactt agtgtcctaa 3201961 gtcatcctta attcatactc ttcctgacga ttaattctgc gcccacatat aatgttttta 3202021 ccgttcttct cttgtcctgc acttgttcaa gcagtaattg aacagcgttt ttacataatt 3202081 catgtatatc aatatgaaac gtcgtcagag gaggcgagac atacttcgcg aagctgatgt 3202141 tgttgatact cacaatgctt accctgtttg gtatggcaat tcctttttcg ttcagggctt 3202201 gcagacagcc cactgcaatc gggtccgctg caatcataaa agcagtcgga agctgatcgc 3202261 ctaatgtgtc gatcgctgct gacatcaggc ggtagccgtt ttctacagag aatccgcgat 3202321 gacagaaaat atagcgctcg tccagcatgg ctttttccct catataggat ctgaaggttt 3202381 gttcacggat gtccatttca tcctgattgg tattcggatt tttgtatgtg ccgccgataa 3202441 aaccgatgct cttatgcccc ttctcagtca ggatgtttac cgtcttcctt gtcatttgtg 3202501 ccaaatcggg ccttaccgag tcaaaatgat cgggatcagg agttgaatcg atgaacacgc 3202561 cgttttcagt gagatttctg aggaaagcca gctcttcatc tgaaaatgtg ccgacggcaa 3202621 taaacccttc cgtatgttca ggaatgctct cgattccatc cgctatttta taagtggtca 3202681 tatcgacatt gaatgctttc gccagtttct ctacttctaa tctcatcgtt ttaaaataga 3202741 catcttctaa ttcttcttta tctgtcagcc aatataaaaa cgcaatatgt ttcaccagcg 3202801 gccttactgt ttttttgcgg taattgagct tttccgccgc ttcatagatt ttctcccgtg 3202861 tctcatcagg aacagaaagg ctttcatcgt tatttaaaac gcgggaaacg gttgagattg 3202921 aaaatcccgc ttcctgcgcg atatctttaa ttgtcgccat tgtatctgcc tccattattc 3202981 agctcgcatt gttttagtaa aatattttac tttctttttc acaaatgtca agtgcacaaa 3203041 gccctctggc tgccatgtaa aaagactgaa ccatttgcgg ctcagtctca gttgttcgta 3203101 tcattcggaa ccggcggaat tgcccgggaa atgagttggt tattgcacat tttcctcgaa 3203161 atatcccgaa agcacatctt ccacattcgt caaatgcgcc agcatggcgg cttccgcctg 3203221 tgcaccgttc ccggcagcca cagcattgta aatccgttcg tgctcctcat acagccgctg 3203281 aacggaggtc ttcttggaaa acagccagat tttcctcgtt tccctcattg tttccagcag 3203341 caatgatgac acgtgattca tcaagtgttt aagaagttca ttttgagaag cgtccgcaag 3203401 cgcaagatga aatgcaaagt ctgctttctc tcccagctcc ccgtccgctt caatgctgcc 3203461 catttccttt agtgcatcct gaattctttc gagatctgct tctgtccttt tttcagccgc 3203521 tagtgaagcc acgccgattt caagcagttt tctgacctcg agcagctgct tgacgtcctc 3203581 ttttttcatc agaagggcgg ctgagagcgg ctgagaaatt tgattgagct caaattcctt 3203641 cagatacgtg ccttctccct gtttcatttc gacaagcccc atcgctttta gcgcagaaag 3203701 tgcttcgcga accgctgaac ggctgacttg aaagctctca gcaagcgcct gaacagagtc 3203761 cagtttatcc cccggcttca attcgccatt tttgatcata tctaataggg catccgctac 3203821 ttcttcatat atttttttgt tttaatctgt ttatatttca atgcaattca ccccgtaact 3203881 tgtaggtctg gctgtttacg atctattata ctctgttttg tgggccgcca aaagattttg 3203941 actattttgt caaaaagtct tgtactttga tttttttcaa aatataatgc taggtaactg 3204001 gtcttattac ccagtcatca gatgatcata tcatctatag aaaccgctta catatggcgc 3204061 cagtttatgt ttcaaggagg ggtttgggat gcaatggaca caggcatata cgcctatagg 3204121 gggaaatttg ctattatcag cgcttgccgc acttgtaccg attattttct ttttttgggc 3204181 actcgcgatt aaacggatga aggggtatac agcaggcttg gccacattgg ggatcgccct 3204241 tatcattgct gtattggttt atcgtatgcc ggcggaaaaa gcgctgatgt ccgcgacaca 3204301 aggagccgta tacggattgt tgccgatcgg ctggatcatt gtgacgtctg tttttttgta 3204361 taaaatcact gtgaaaacgg gacagtttga tatcattcgc agctctgttc tctcgattac 3204421 tgatgaccga cggcttcaag ctctcttgat cgctttttca ttcggggctt ttttagaagg 3204481 ggcagcaggc ttcggagcgc cggtcgccat ttctgccgcg ctgctggtcg gtctcggctt 3204541 taatcctctt tatgctgcgg ggatctgttt gatcgccaat acggcgccgg ttgcctttgg 3204601 ggcaattggg attccaatta cagccgtaga agggccgaca gggattccgg cgatggagat 3204661 ttcgcaaatg gttgggcggc agctgccgtt tttatccgta tttattcctc tttatttaat 3204721 catcatcatg agcgggttca ggaaagcctt ggagatctgg ccggcgattc tcgtatccgg 3204781 tgtttccttt gctgttgttc aatatctcag ttccaatttt ttagggcctg agctgcccga 3204841 tgttttgtca gctcttgttt caatggctgc gcttgctgtg tttttgaaat ggtggaagcc 3204901 gaaaacaaca ttccggtttg ccggtgaaca agagtcggcc gcctcaattg aaacggcgcg 3204961 cacaaatccg gcggcgcctg catacagagg cggacagatt tttaaggctt ggtcgccatt 3205021 tctgctgctg acggcgatga tttccgtatg gggcattcca tctgtcaaat ccgcgctgac 3205081 cgggcattat gaaggctctg cggtgttctt gaagtggctg aatgctgttg gagaaaaact 3205141 gactttttcc cccggtgtgc cttttttgaa caatcagatt gtcaatgctg acggtacgcc 3205201 gattgaagcg gtttacaagt tggaggtgct tggttcggcc ggcaccgcga tattgattgc 3205261 cgcagtgctg tcaaaattca tcacggcgat ttcgtggaaa gactggggaa ccgtttttaa 3205321 agaaacagtc caggaattga agcttccgat tttgaccatt gcttctgtcg ttggttttgc 3205381 ctatgtcacc aactcctcgg gaatgagcac gacactcggg atgacactcg cgctgacagg 3205441 ttcgatgttt accttctttt cgcccgttct cggctggctc ggcgtcttca ttaccggctc 3205501 ggatacttct gccaacctgc tgttcggcaa cctgcagaaa gtcaccgcat tatcagtcgg 3205561 catggacccc gttctgtctg tggccgccaa ctcttcaggc ggtgtcacag gaaaaatgat 3205621 ttcaccgcag tcgatagcgg tggcgtgcgc cgcggtagga ctcgccggaa aggagtcaga 3205681 tcttttccgc tttaccatta aacacagtct gtttttgctg ctgctcgtct gtatcatcac 3205741 ctttttgcag catcacgtat tcagctggat gattccttaa aaaaatcctc ccgtctaggg 3205801 aggattttat ttatatcgct ttctcgctgc cgatgacgga atattcattt gatcgcgata 3205861 ttttgccacg gtgcgtctcg agatttggat gccgtgttgt tcatacagca aatcgacaag 3205921 cttttggtct gaaagcggtt ttgttttgtc ctcttgattg atcaggtttt ccagatgcgt 3205981 tttgactgca taattcgacg catctccatc acctgaagcc tcggcttttg ctgagaaaaa 3206041 gagtttcatc tcaaacagcc cgtaaggcgt ttgtattgtt ttccctttaa tggcccggct 3206101 cacagttgat tcatgaaggc ttagacagtc tgccacctct ctgagagtca gcggcttcat 3206161 tgcgcttcgc cctttcagaa agaaatcctt ttggcgtgtg atcagttcat tgataattct 3206221 cgtgattgtc tgttttcgct gccgcagcgc gcggctcagc cagcgccact cctgatattt 3206281 cgcagataaa taggagacag tatcctgaca ggagccggat gataaaagcg ttctgtactg 3206341 cggatgcaga tcgatctcgg gaaacgagcg ggtattcagt tccgctgcga tgtgcccatt 3206401 ttttacggtg ataaaaatgt caggctcaat atacacatct tgctctggcc gggcaaacag 3206461 aaggccaggt ctaggatgaa gagccgcgat atcatctgag atatcttgaa tggtatgaag 3206521 cggaattccc gtctctactg aaagcgtttt ccattttttt tgcgcaaaag catcaaaatg 3206581 agctgaaacc agcatttccg cttgttcatt tctgttcggc agccgctgta attgaagaag 3206641 gatgcattcc tgcaaagatc tcgcgccgat tccagccggt tctaacgact ggagttttgc 3206701 caaaacagcc tccgcttcct tggccgatac agataatcgc cgtgctgcct cctctatatc 3206761 ttcttccaag tacccgtttg aatcaagcga atgaatcaga taattaaaaa tctttttttc 3206821 agtgtttgtc agattcatat cgagtgactg ctgttttaac gcatcctgca atgttttttg 3206881 cggattactt aattgaaggc ccgcttcctg tgcattcatc ctgtttttgt ttgttttatg 3206941 gtaagatagt ggcggtgtgt ctgtttcctt tcgttcaata agagggtttt ccagtgagag 3207001 ctcatcaatg tactcggcga gttctgccga atgatagcca agcagcgtga tggcctgcct 3207061 gagctcctgt gtcagttgag gctttaatac ttgtacttgc tgaagtttca tatccatctt 3207121 gctcactccc ctttcttcat tgtacatgat tgagatcaca ccgtatacat ttatgaaaaa 3207181 ggagctgcca aagaaatgtc tgaacttttt tccgtccctt attttattga gaatttaaaa 3207241 cagcatattg aaatgaatca gtctgaggat aaaatccacg cgatgaacag ctactaccgt 3207301 tccgtcgtct caacactagt gcaggaccag ctgacgaaaa acgcagttgt cctgaaacgg 3207361 attcagcatt tagatgaagc atacaacaaa gtcaaacgtg gagaatcaaa ataaaccttc 3207421 cgctcacatg tgagcaggaa ggttttcctt ctttgaggcg tgctggatga gacgggtgct 3207481 tggcacgcct tccatccagg tatgaaagta attggcgttt ttcccgtagg aattatcaat 3207541 gaccgtgttt tctttttgaa gaagagaaga caggatgtgg ccgtgcagcc ttgatgtttc 3207601 caccgattcg taacggctga aaaaccgaat cgctttttgg acgatataat ccgagtattt 3207661 ttcccatata tacgcaatgg gcaaagggtt gcctgctttt ttattcaaga cgttcagcgt 3207721 ttggagaaaa gcaatcgtcc ggcggtctga agctgacagc accgtgcgcc agtcgtagct 3207781 ttccgcttct gcgtgttcct gaagcgcctg gtttgcttca tgatctgttc ggataaatct 3207841 cagcttttga ttggacggct gctgcgtggg aatgacggga aacagctgat gagccatatc 3207901 aggcagaagc tgaatgtgat ttgttgtaaa ataggcctgt gccgtagcat aggaggcttt 3207961 ttcccttgtc atgatgtgaa ggttcgcatg cttagaaaat atctctgccg tccgcttgag 3208021 gttgtctttg ttttgaaaat aaatcgattg cggcaggatc acaattttgt ggttcggata 3208081 ggtttggacg attttctctc taaagccttg ataatacgga tacagatccc cgaagtttcc 3208141 gcctccctgg cagacgatga tgagattcgg atcaagcttt cgcccgattg ggaaattgtc 3208201 tggattccag cgttttctga cccgaatccc gtgttcttta aagaaggctt ctgttccttt 3208261 cataataaat aaatccccta cattcccata tagaggatag tcagcatata taatctctga 3208321 ttgtttcgga atgacgtcga gcagcccgga cagtttctgt ttcaggctga tcatcgaatg 3208381 cttgctgtcc atttcttcac ctcgacagta tggaataagt gcagtagcac ttcaatgacc 3208441 cggccttgct catcttctgt catattggac cccgatggga gacagattcc tcgcttgaac 3208501 aaatcttcgc atacgcttcc tgtatcttca tgagaataaa ataaagccgg atcgaacagc 3208561 ggctgggtat ggagcggctt ccacagcgga cgggcttcaa tgttttcttc agcaagacgt 3208621 tgaactatgt catatgggct gagcccgtta tcaagtgtga gcgtggtgag ccagcgattg 3208681 gatacgcctg ctgcgtactc tggcataaag cggacgccgt ctaagtgacc gagcgcattt 3208741 ttgtatctcg tgaaaatggt ccttcttttc tccactcgct catccagcac ctcaagctgg 3208801 gcaatgccga cgccggctaa gatattgctc agcctgtaat tatgtccaat ttcactgtgc 3208861 tgataatgaa cagccggctc tcgtgcctgc gaagcgagaa atcttgcttt ttcaattgcg 3208921 gcttcatcat ttgaaacgag catccctccc cctgatgtgg tgatgatttt gttcccgtta 3208981 aatgaaaaaa tgccgaagcg cccgaatgtt ccgctttgct tccctttata gactgtgccg 3209041 agagattcgg ctgcgtcctc aatgacagga actccgtatg catcacacag gcttacgatt 3209101 tcatccattt tcgcgctctg cccatataga ttgacggcaa ttaccgcttt tggcagtgtt 3209161 ccgtttcttt tcgcttcctc caatgctctt tcaagggctg tcggcgacat attccacgta 3209221 tcaggctcag aatcaataaa gacgggcacc gctttttcat atagaatcgg attggcggtt 3209281 gctacaaatg tgaaggactg gcaaaacacg ctgtcacctt cttttacctc aagcaaacgc 3209341 agcgcgagat gaatcgccgc cgttcctgag ccgaccgcag ctgctgcttt tacaccgact 3209401 cgttctgcca gctgttcttc aaatgaattc acgagcggcc caagcggcgc aatccagttt 3209461 gagcgaaagg cttctgaaat atagtgctgc tccctgccgc tcatatgagg gggagataag 3209521 tagatttttt tatgcataga atcatccttt gtttgatgtt tgaatggaag aaatgatgcg 3209581 tgccggagca ccggccgccg ttaccctgtc cggtatggaa cggatcaccg cggagccggc 3209641 tccgacaatg ctccaagccc cgattatgat ctgcggtatg acggatgcac cggttccgac 3209701 gtgagcgcct tcctgaacgg aaaccgctcc tgacagcgtg gcacgcgggg acagatgaac 3209761 gtaatcgctg atttgattgt cgtgctctgc cactgcaccc gtattgatga tgcagtgggc 3209821 gccgatgcgc gcatccgcct gaatgatcgc gcccgccata atcactgtcc cttccccaat 3209881 gacagccgac ttgctgacga tggctgacgg gtgaatcaat gtaataaaat catctttccc 3209941 cagtcccagt cgctccgcca gctgttttct gacactgtta ttcccaacag caatcagaaa 3210001 cagcacatca ggaatgagcc tgcgcagttc agtaacggct ttcggcggtc ctgtgtacca 3210061 ttcttttccg ccttcgaacg ttttgaattt atcatccagc accgcggcta agcgcgtatc 3210121 tgagcgggcg tttatcagct ctctgatcac ctttccgtga ccgccgtcac ccacaatggc 3210181 cacatttttc atgaggacac atctccgctt ccggtaaacc gttccgcggt cacatgattg 3210241 gtttgctgaa tcccttctga aacaaggacc tttcgcaccg tcaaacataa aattttcaaa 3210301 tcgagaaaaa atgaccagtt gtcaacgtac caaacatcta attcaaattt cttttcccag 3210361 gaaatcgcgt ttctgccatt gatttgcgcc cagcctgtga tacccggctt cacctcatgg 3210421 cgccgtgcct gtttttctgt ataaagaggc agatagtcca tcaaaagcgg ccgcggcccg 3210481 acaaggctca gatcgccctt caggacattc aggagctgcg gaagctcatc aatgctcagc 3210541 tttctgatca gcctgcccgt tttcgtcagc cggacttcat caggcagcag atttccttta 3210601 ctgtcccgtt catccgtcat tgtccggaac ttatataggg tgaacggttt gccgtgcagg 3210661 cccggcctta cttgcttaaa gaagacaggt gatcctattt tcagcctgac aacggcgatg 3210721 gtgaacagaa tgatcacact tgtacagcac aacaaaaaaa tggcggccgt cagatcaaaa 3210781 agtcgtttca ggatcaaaga ttcacagctc ctttcgtttt tcgaaaccgt tttaatacca 3210841 gctgtctttc ctcttttgta caaacgagca taaaagcgaa aacagcgtag caaaagctga 3210901 ctgtcactcc cgtcgctatc aatgacggcc agctgtcaat cttcacaatg aactgaattg 3210961 ccttacagac cgtccaggca aatacagcgg ctgaaagagg cccgattatg cctttaagga 3211021 acacgtgctt tttgtagcct gtaatgcggg atacgtaaag cggcgtaaag atggcatttt 3211081 ttaaaataag agaaatggcc cctgccaatg ttatgccgta cagaccgaga tgagccggcc 3211141 cgctcagcgt gaccgccagc accacattca ccgcacctaa cagcagggta acaatcgccg 3211201 gtgttttttg ttgattaaaa gcggtccata tataaaacag cggcataaag gcgaggctga 3211261 caaccaagta tccggcatga ataaataaaa gcggtgctat cgttgaaaag gacggtccga 3211321 gccagattgt cagaaaaggt cccgccaatc cgcccaataa ggcagcagga agtgcaagca 3211381 aaagaccatt gagccttact gccttattgg cgtaattcat caatccttcc atatcgcctt 3211441 ttgaataata tgaagtcatg atgggcgcaa acagggatgc gaccgttccg gccaagctgc 3211501 gcaaaagcag cggaaactgg ataatcgccg cgtatttccc ggatgcagac gcccccagca 3211561 tcaaattggc ggttaacaga tcaatctgca aaaaaagcag gacgccgatt tgattgacgg 3211621 agctccatgc gcccgcttga aacagctcct tgcttgtacg gaatgaaaga tccttcatac 3211681 gaaacgaaaa ccacggaatc agctttttga agaaatagaa agacagcaca gacgcaataa 3211741 cagcaccagc taaagctgca agctggatct gccagatttt cggcgcaaag catgcaaaca 3211801 ggagcagcac agacagcacc cgtataagca tttgcaccgc ctgaatggaa ctggtgatat 3211861 aaaggcggtt ggcataaaat ggtgcagcgc cgaagcccgc catcagaaac gttaaaataa 3211921 acagcacact gccgattaaa atcgacaaac gcacatctgc caaaagcgct tgcggcacat 3211981 tcatgacgcg gtcaataaaa aaagccgaac ccgcaagcgg cagcaagagc agcaaggaaa 3212041 tcaaaacaga ggcggctaaa taattgctga tatacgcatt tgctttctcc cgctctcccc 3212101 tgtgggcagc aacagaaaag aaccgaacga caaccgagct gagcgccacg gtaataaccg 3212161 aaaagtaatt aatcacattt tgtgtcaagt gaacaaagcc aaacgcttcg acaccgagcg 3212221 ttttgacaat aaaaggcgtc atccaaaccg ataggaaaac agacaagaga aaagccgtga 3212281 gattcgcgct gaaatttatc gtgaatttca tgcctgcttc gcactgcctt tcattgtccc 3212341 ccgctgctcg aaaaacagct tgatgagaaa agtgagccgc catttacaca gtgctaatac 3212401 caaacgctct cctcttaata atttctcatg ctgaaacggt gtatgtctga cagcctgccg 3212461 caccatgtca taggataaaa tctgtctgat cttctttttg atgtctttcg gcgaattcgg 3212521 agaagcacag gcatttgcca aaagcatcgg aagctggtgc ctgcaaatgt acacattcaa 3212581 atcttcttta catgcgcctg ctaagccgta gtgattgtag aatgcgattt tagcctgata 3212641 ttgtttttga agatgttcat ccatcgccgg cttataaggg atttctgtca ggctgttcgg 3212701 gttttcacga taaatgtaca atccttcatc aagcattttc acccgctccg cttcgcgaaa 3212761 agcggacaaa ttaaagggag agtcttcagc aaaacggatg tcttcatcaa acagcagatt 3212821 cgccctttca aaaagctcac gacggtaaag ataacgccat acataccaga taaatctcgt 3212881 ttcgtgagca tgtttaagct gttcagtcat ttctggtttc gtcagcacgc ggtttgcctc 3212941 aagctgcggc ggcacatatg tccgcctgtc cgatgactgc ttgtaaaaac cgcatccgac 3213001 gatgtcaagc tgattttgct ccgcttcttc agtcagcctc tggaacatgg cggatgatac 3213061 ataatcgtct ccgtctacaa agccgatgta agtgccccgc gcggccttta ttcccgtatt 3213121 tcgcgctgaa ctaagcccgc cgtttgcctg atgaatgacc cggattctcg catcccgttt 3213181 tgcatagtcc tctgcaattt cgcctgaacg atccggtgtt ccgtcattca cgaggatgat 3213241 ttcaatatca gaaagcgttt gacgaagcaa agaatcaatg cactcttcta taaatggttc 3213301 aacattatac atcgggacaa taatgctgac gagcgggatc attgcgcttc accgctgatt 3213361 ttgtcacgca gacctttaaa atacacatct ctcggaaagc ctgcacggga tgtttctttt 3213421 gttaaaagct cattgactgc ggctgttacg cgctctggct ccggatgttc tatcagcttc 3213481 atgaacggga tgtctttaag ccattgatag ccctccatca ccttatggtc aaaggagcga 3213541 atgacaacac acggcgttcc tgtcagcgcg caaaaaatca tgccatgaag cctgtcagtg 3213601 acgacggctt ctgcgctttg cagcttagac cacagtgctt caagttcatg ttcgcgtgta 3213661 tcgcggctga cccggcggcc gatcgttgtc gtaaaggatt tgatctcgcc gaattcctca 3213721 catagcgcag ccttgacccg gttcctctgc tcctcctgaa gcacgctttc ctgatcctcg 3213781 cgcaaacaca tataaacccc ttcgcgttct gcgggagcct tgcttctgtc taaatacagc 3213841 accatgtccg gctgcttcaa aattgttttt tcttgaaaat gctgtttcat aaattgatac 3213901 gttgtttcat cccgcgccat cagcaatagg ccggggtgcg cattataaat tttctgtgcc 3213961 cgtttcagct ctttgcgccc ttttttcgtg tcagaaaaat gagccgttgc cggaagctgg 3214021 acaacccgat agtcatggaa tgttttaatg atgaagcggc gcgtccactc ctcataacgg 3214081 tataaatccc ccatgtttcc gccgccgatg ataaagacca tatcctccgg atggcgcgag 3214141 cggatcaggc tttttgctga tttgtaaatg tccttcatat cgacctcgac gatgtcaaag 3214201 tccgggtatt cttgctcaag aaatgccttg ctggcataag caattgcgtg atctcccaaa 3214261 ttgtcatggg acggcagcag ggtcagtatg atttttttct gatgtgctgc ggcctttacc 3214321 ggttgatctg ccgctcccag ccaatattgg gacgggtatt tgacctttag cagcagccat 3214381 tctgcaaaat tgattttcaa cgattgtaac gacatgtcct caccctctgt ttctcatttt 3214441 gtactcgatc acccgctgat acacagccga tgccatagcg acgaacggaa tcattctgta 3214501 tttcgccatc agaagcaggc atgaccgttt tgcgtcaaaa ggagcagtac ccgtttttga 3214561 aagactttct tgaaacaccg ggtccgcgca tatcacgcca acatttctaa gcttttcaaa 3214621 cagccggcgg ctgccgctcg ttttccattc attcagcata cagatgctgc tgtgaagaac 3214681 gataaaggta tcaagctcct tgcgatactc ctccagtttg ttgttctcct gtaaaaacgc 3214741 cgcattcgtc tcatacagcg caagtcctga ttcaaacaat tttttctgat agcgctgcac 3214801 aatggaggaa aggtgaattc gataatgata gagcggcgtt tttacgtagg atactgagcg 3214861 ggcgaaaaaa tgagccctga agctgaaaaa ctgatcctcg acatgctcca gctcgcctcg 3214921 gagcggaaac gacagccgat gggcttcaat catgcttctt ctgtacagtt tgttccatga 3214981 aaaccctctg accttccctt cgaataacgc cttgatatag tgctccttcg gctgatcctg 3215041 ataggtttgg gcaatgtcag agtccatggt tttgccagtg tcctcaaact ctgcggcgta 3215101 attgcaaatg accagatcag tttcatcgcc tgctgtccgg agcatctgct cgcaataatc 3215161 aggctcaatc caatcgtctg aatcgataaa cgcgataaat tcgccgcgtg cagcttcaat 3215221 gcctttattc cgaaccgcac cgagtccctg gttttcctga tgaatcacct tgaacctgtt 3215281 gtccattttg gcgtattctt ctgcgatatc cgggctggcg tcagctgaac cgtcattgac 3215341 aatgatgatt tcaatattgt ccattgtctg gttccgcagt gattcgagac acgttctgat 3215401 atatgtttct gtgttataaa cagcgactaa cagactaacc gcaggtgttt ccataatgac 3215461 cggctcctcg tgcataaatt accgggaaaa aatcgttctg taaggcagaa ccgatgaatc 3215521 gaccggcata agcaaataac tgtaaagaaa ataacaaaca acgatagcga tatagataag 3215581 agcgttcgat ttttcatcaa atatcctgac gaaataaggg actaggatca tttgatacag 3215641 accgaaataa atattgaatc tggcaaaaat cacgtccttt gtggccaaaa ggccgaacaa 3215701 aaaacctagc aggcacaaat tgacgacaat atcaatttgc ggccacagac tccgcagtcg 3215761 ttctttatag caaaatgcaa ggaacagcgg cagaaccaaa acagcgattt tgatcacatt 3215821 cattccattt gtgttcgtca tgagccattt ttcataatgg ctgtatgagc tgttttcaag 3215881 tacaacgaca aacacagaaa taaatttttg atataaaaat gtcatgccga gaaataaagc 3215941 ggataggccg aatatcgccg gtgaccaggc ttttcttctg acaataaagt acactggaat 3216001 cataatcagc gccgacgaat gaaagagcga gctgaccagc acaatcagga aatatcgctt 3216061 ccagttcccg ctaatgatat aacggatcgc ccaaaacaaa acagctgcca ccatgtattg 3216121 cctgatgccg ttaaaagatg cgtaataatg aaaggttccc aaaaataaaa agacactcag 3216181 ctcaaacggc ctgccatagt cggcgagtgt cttcataata aagctgtagg tcacgaccgc 3216241 caccgtaaaa tacatgattt gaggatcttc cgtgatgaaa ttcatcagcc aaaggagtgc 3216301 ggtaaacccc ggatctgtcg ctgttttcgc tgtgccgaaa ccgaatatct gccacacatt 3216361 ttgataatcg cccgccaatt cgtacaacag cgtgtacgtc tgaaaatccg tgccgactcg 3216421 atagcggaga cctgacacga gcacaagtga agcgagcgga atccagatca aaagcttatt 3216481 cggccgatac cccgtggcaa gcgaatcatc acggccgccg cacattttag cgaaccaaga 3216541 ccaaataaat acaatcccca tattgacggc atatacaatc atcggttatg gtccttttcc 3216601 gtgctgatgt tgtatacatt cagcagcgct cctacatttt gctgtgcatc gtagccaagt 3216661 tgagcgagtg tttctttgat gaactcacgc ttcggcctgc ctgcggcggc cgcccttgca 3216721 atggtttcag cccagacgct gatcggctca gaaagactta atcttgtgac aagcccgaga 3216781 ccggcgtcga ctttttctgt aatgctgtct gaaatgatgc atggaagccc cgacgcctgc 3216841 gcttccacaa gcacaaccgg caagccttcg tacagagacg gcatgacaaa tacatcgaat 3216901 gttcgcatca gttcatggat ccgttcttcc gtgcctaaaa agaggacgtc tgatagcaaa 3216961 ttctgctgcc gcgcctcctc ctctatctcc ccgcacaacg gcccgtctcc cgccagaacg 3217021 agctgaaagc gaatgcctct ttccttgaga tgtgcggcaa gcttcaacag gaacgcgtgg 3217081 tttttcactt catgaaaccg ggccacatgg ccaatgatga gccggtcggc tgcaatgccg 3217141 cgtgctgctt tttcttcatc agccgcctgc ccatttgggg cgaacaactc aaggtcaatc 3217201 ccgttaggaa gaaggtgaac acgctcccgc tccatattgg actgtccaaa taaaaacctg 3217261 cccgcatcct ctccgcaggc acacagcgct gtcgcatttg ccaaaatgag ccgcctgaac 3217321 acgagcagct gcaatcgatc cttccagttg aagccggtct tccaagacgt attgtgggag 3217381 tggcataccc tgaccggcac tccggcgagc cttgccgcaa gggcgataaa acccgtttgg 3217441 aaatccgtgt gcgcatgaac ggcgctgaac ggcccatttt cttttatcgc gtttctcaca 3217501 ttcctcacaa atgtaagggg attgctttgc ccaatgctcg ggacataaaa aagccgcccg 3217561 cctaaagata aaatctcttc atcataagcg cacggatcat ttcgatacgt taaaaaatca 3217621 aattgcactt tgcttttgtc catcttccga tataaattca ttaccatggt ttccgcgccg 3217681 cccctgttca tgccgctgag aacatggagc acgcgctttt ggctgctatt catgcttgac 3217741 aagcccttcc ttttggttca tcactctttt tttatggtag cgattcatca cagctgcagg 3217801 cataaaggcg cgaattaacg gttttgcgat atatatgtaa tcagataaag gaagcttcaa 3217861 gcgtctgcac gcctgataga caagaatggc attgtcgatt gaatacgtaa atgaccgccg 3217921 tttgaatgca tcgctgtctt ccctcacttt atacaaggct tcctgaagat tatagcccct 3217981 gaagccctct tcaaaaaagc gaagccacaa atcaatatct tccattcgtc tcgtccgccg 3218041 caccgaccgg tagcctttca gcgtgcggta ggcactcgct ctcatcataa tcgtgccgtg 3218101 gcaaaatgga gtcccttttg ccatgatgcc cggctccgga acagaaggca gaatgcgggc 3218161 gcctcttacg ccaaattcat caaacacaag catgccggtg ccaaccacct gatagtgtcg 3218221 gtgcttttct aaaaacgcga cctgcttttc cagacggcgc ggaaacgaaa ggtcatctcc 3218281 gtcctgacgt gcgatataat cgcctgtcgc atgcgaaaga caatgattta atgatgcggc 3218341 aagccgctta tttgttttgt tttgaatcag tttgatgcgg tcgctgtaat gagcggcata 3218401 ctgcttcgcg atacggagcg tgccgtctgt tgacgcatca tcgcacaaaa tcagctccca 3218461 atttttatag gattggctga gtatggattc tatgctttct gccaaagtgc gttcgcaatt 3218521 ataaatgccc ataatgacag aaactttcgg tcctgagttc atacgctttt ctcctttgta 3218581 tccatatcca tgtacgcgga ataaatatct gccatttctt ccaccgttcg cgcctccgag 3218641 aagcgcaagg ctgtttttcg gccttcctgt cccagctttc ggcagagctc cggcttatgg 3218701 taaagctgtt caatccggcg ggcaaaagca gcactgtcac cgattttgat cagaaaaccg 3218761 ttttctccgt cgcggatgat ttcccgatgc ccgcgattat ctgtggcgat cgccggttgt 3218821 tctgccgcca ttccctcaag cacattcata ccgaggcctt ctctaatgct ggatgcgaca 3218881 gatacatccg caagctgaat caactcatgt atgtcgctgc aaaagccgta aaaacagaca 3218941 tgggcggagg caccaagctt ttcagctaac gtttgatacg tatgttccat tgccccttcc 3219001 ccggcaaaca caaggcggag tgagggaatt ttttctttta gcaaggctgc ggcttcaatt 3219061 aactgcttct ggtttttgtt cagattgagc tcagccggat aaaccaatat aaaatcatct 3219121 tcacggaacc cgtgcttttc tctgagtctt tgctgctcta tcggactgac aggccggaaa 3219181 cgctcggtat tgacgccaat gccgtgaatt ttctgcgtcc ttccgcccgg cctttgaagt 3219241 cctttcgccc gtatgtaatc ctcttcatta atcgtaatca ggcagtctgt atatgctgaa 3219301 agccatttct caaccggata gtaaagaagc caatttttca tcggtgcccc tttgcagaag 3219361 tgaaatccgt gcgctgtgta cagcaccttt gttccgtgcc gccgtgcctg cctcgccgcc 3219421 agtctggcga gaacgccgcc gaccggtgta tggcaatgga caatgtcgta ttcataagtg 3219481 tcaatcactt tcttcagctg cctataaacg gccaggttct gagggtcaaa aggtgacctg 3219541 cgaatcggga tggagaattt ctcatccaca tacggcagct tggtttgtcc gttcgcggcg 3219601 acatgaacct cccagcccat ttgcttgaac catttaaaat aagggaggtg aaaggcctta 3219661 aaatgataat caacagtcgc gcaaaacaat atctttttcg tcattttcac tccccctaat 3219721 gaacgctggc agccgtcatt tcttctgatg tattgattgc cgcaaacagc ctcgctctca 3219781 ggtcggcttc cggcagctca tgaaaatcct cgataaagcg catcagcacc ggccaatcgc 3219841 cgtccaccgc tttaccgatg tgaatttttg gaaagatttg ttcagcatgg acttcatttt 3219901 tgttcagcaa ttcttcatac attttttcgc ccggacgaat gcctgtgaat tcgattggaa 3219961 cctgctcagt cgtgtagccg gacaaatgaa tgaggttttt ggcaagatcc acaatcttta 3220021 cgggctctcc catatcgaga acgaaaattt gacgcccttt cgccagtgcc ccagcctgaa 3220081 tcacaagcct tgatgcctcg ggaatcgtca tgaaatagcg ggtcattgcc ggatgtgtta 3220141 ctgtcaccgg gccgcctttt tcaatctgtt ttttgaaaat tggaatgacg ctgccgcggc 3220201 tcccgagtac attgccgaag cgaacagcaa caaatttggt tctgctgact ttcccaagat 3220261 tcataataat catctctgcg aatcgttttg tcgcccccat tacgttggct gggttcaccg 3220321 ctttgtccga tgaaatcagc acgaatgtct cagttcccga catatcggct gcttccgcga 3220381 cattttttgt tccgataata ttgtttttga ccgcctcttc tggattgtgt tccattaaag 3220441 gcacatgctt atgggcagct gcatgataga caacatgcgg ctcgtatttt ttcatcaagg 3220501 taaacatttt atcgcggtcc tgcacatcag cgatttccgt atggaacaca atgtgtttgc 3220561 cgaatcgtcc gttcagctct gtataaatcg aatgaatgct gttttcccca tggccgagca 3220621 gaatgatttc cttaggctga aacgcgctga tctgacggca gatttccgag ccgattgatc 3220681 cgcccgctcc cgtgacgaga actgtttttc ctttgatgcg gttcgaaatt tcgctagtgt 3220741 cgagggttac cggctttctg ccgagcaagt cctcagcttt tacatctctg atttgtccgg 3220801 cagttcgtgt gccaagcagc atttcatcaa aatgaggcat aattttaatg cttactccgg 3220861 ttcgcacaca ttctttatat aacacctgaa gctcatgggt gcggagtgaa ggaatggcaa 3220921 taataatata attaattttg agcttttgca ccgcaggcat gatactttct tttccgccga 3220981 ttacgggcag ccccataatt tctaatttat gcttcgtttg gtcgtcatca ataaaagcga 3221041 caggtatgat atcaggttca tctttcgaaa gcagctgcct gaccatcaga gtcccacctg 3221101 agcccgcccc gataatcagc gcgcgggacg aggcgcagcg ttttttcctg atgctttcgt 3221161 ttaatactct ggataaaata cgggtccctc caatagacaa aagctgaagc acccagcacg 3221221 cggttaacag acggaagaac atcgtgtgat acacagcata ctgaatgacg ccggtcacag 3221281 cggctgaaag cgtaatgccc ttaagcagga caatcagctc gccaagcccg gtgtatgtcc 3221341 acacctgttt atactgattg aacaggaaag cacacacatg atagctgagg agcaagctga 3221401 cagcggtaag cagtaatgct ccggagtcat aaaattgata ggaatctttt aaaaattgat 3221461 atcctgcaat aactgaattt aaaacgaggt aagtatccag cgcaataatc attgacagtc 3221521 ttctccggta actcaacctt ttccccccta attcttttat cggtttagct gcggcggttt 3221581 tcgtctctcc aaaaaatcgg cagcagctaa accgacaata cgtcctatgt atatatgaga 3221641 taagtgggca tttaacccat cctcacgccc cgccagcgac gaccagcatc taaggcagca 3221701 acttcagctg cccacagcag agccgagtgc ctccattgat acaggtcagg agacatcacc 3221761 tttacaaaaa ctagtaggaa tagtgttccg attttttcat tttctttttg tttaaaagag 3221821 cgcctaacag cttcgcattg gattgttcca gtgcatcttt tgctttcaga acggtatcgg 3221881 tttttgtttt tccgcttaaa acgacgagca cgctgccgtc tgtctgattt gctagaatct 3221941 gagcatctgc aacagccaaa agaggagggg aatcaaagat gacgaggctg aattgttcat 3222001 agatctcaga tattaaatct cccattgctt ttgaagacaa cagttctgcc gggtttggcg 3222061 gggtcggccc gcttgtcagt acatataagt tatcgatcgg cgtcttttgc accgtctcac 3222121 tgagtgaagc attgccgacc agcacatttg tcagcccggt tacattatca acctgaaacg 3222181 tctgattgat ggtcggcttt cttaaatcgg catccaccag cagtactttc ttttcctgct 3222241 gctgcgcaaa gacagccgca agattcgctg cactgaacga tttaccttca ccaggcacag 3222301 aggaggtgac gaggatagat cgcaagttgg tctggacaga tgagaactca atgtttgtcc 3222361 gaatggtgcg atattgttcc gcaacaactg atttattgtg taaaacagat atttgagcca 3222421 aacctcgcct tgctttcttt tttctaaaga tcactcgctt cactccccga aatgttttat 3222481 cccgcgattc cgccctttgt ggacatcagg aacggagcct aagcatggca atccggttct 3222541 ctcgctgagc tgccgtgcgc ttttgcatgt atcatcgaga aaatgcagaa aaaatgccag 3222601 tgtaatgccg cccatgacag cagcgccaaa agccatgacc atatttcgca gcctggccgg 3222661 cttgatcatc gggctttccg aagccttcgc ctctgataat atatgtacgc cttgtacatt 3222721 cattctttca tctacttctt tttcaaactt gttcactaac gtgttcgcaa tctcagctgc 3222781 tttcgccgga tcgtgatcct gaacggcaac gttgattatt tctgattcat tttcactgct 3222841 ggtaaccact tttcctttca gcgaggaagc cgattcagat aggtgcaatt ccgccttaac 3222901 ttcttccatc aaggcagtgc ttttcataat cgattggaac gtgctgctat actgaagatt 3222961 tcgctggatg tcactgagat tcgagttttc ttcaccgtct gattcatgaa ccagcacctg 3223021 tgtcgacgcc tggtaggtcg gtgaaatgac cttaaattgc acaaaaccca taataagggt 3223081 gacgccgatt gtgatgagca gaatcagcac gaatctgtgt ctgacaatcg catataattc 3223141 tttgaaactc atattctcat tcatgtattc atagccttca gccttcccgc ggctggcttc 3223201 ccgcgcccct ttctgttaat gattggatta taaaagaaaa cgttattatt taaaaattgc 3223261 aaaataagcc aataagttct ctttagagaa caaaatcatg attttcctct aatttactgc 3223321 acttccctta ttattttaaa ttttataaag aacgaaaaat tccttataat gaacgaaata 3223381 acgacaggaa tagaggagaa tttcatatta tgattggaag aattatccgt ttgtaccgta 3223441 aaagaaaagg ctattctatt aatcagctgg ctgttgagtc aggcgtatcc aaatcctatt 3223501 taagcaagat tgaaagaggc gttcacacga atccgtccgt tcaattttta aaaaaagttt 3223561 ctgccacact ggaagttgaa ttaacagaat tatttgacgc agaaacaatg atgtatgaaa 3223621 aaatcagcgg cggtgaagaa gaatggcgcg tacatttagt gcaagccgta caagccggga 3223681 tggaaaagga agaattgttc acttttacga acagactcaa gaaagaacag cctgaaactg 3223741 cctcttaccg caaccgcaaa ctgacggaat ccaatataga agaatggaaa gcgctgatgg 3223801 cggaggcaag agaaatcggc ttgtctgtcc atgaagtcaa atccttttta aaaacaaagg 3223861 gaagatgatg atcggttaaa gggctaacgt tcgcatctat aggggaaatc tgtttataat 3223921 gggggaaaaa gggagagaac acaatgactc atcaaatagt aacgactcaa tacggcaaag 3223981 taaaaggcac aacggaaaac ggcgtacata agtggaaagg catcccctat gccaagccgc 3224041 ctgtcggaca atggcgtttt aaagcacctg agccgcctga agtgtgggaa gatgtgcttg 3224101 atgccacagc gtacggctct atttgcccgc agccgtctga tttgctgtca ctttcgtata 3224161 ctgagctgcc ccgccagtcc gaggattgct tgtatgtcaa tgtatttgcg cctgacaccc 3224221 caagtaaaaa tcttcctgtc atggtgtgga ttcacggagg cgctttttat ctaggagcgg 3224281 gcagtgagcc attgtatgac ggatcaaaac ttgcggcaca gggagaagtc attgtcgtta 3224341 cattgaacta tcggctgggg ccgtttggct ttttgcactt gtcttcattt aatgaggcgt 3224401 attctgataa ccttgggctt ttagaccaag ccgccgcgct gaaatgggtg cgagagaata 3224461 tttcagcgtt tggcggtgat cccgataacg taacagtatt tggagaatcc gccggcggga 3224521 tgagcattgc cgcgctgctt gctatgcctg cggcaaaagg cctgttccag aaagcaatca 3224581 tggaaagcgg cgcttctcga acgatgacga aagaacaagc ggcgagcacc tcggcagcct 3224641 ttttacaggt ccttgggatt aacgagggcc aactggataa attgcatacg gtttctgcgg 3224701 aagatttgct aaaagcggct gatcagcttc ggattgcaga aaaagaaaat atctttcagc 3224761 tgttcttcca gcccgccctt gatccgaaaa cgctgcctga agaaccagaa aaagcgatcg 3224821 cagaaggggc tgcttccggt attccgctat taattggaac aacccgtgat gaaggatatt 3224881 tatttttcac cccggattca gacgttcatt ctcaggaaac gcttgatgca gcgctcgagt 3224941 atttactagg gaagccgctg gcagagaaag ttgccgattt gtatccgcgt tctctggaaa 3225001 gccaaattca tatgatgact gatttattat tttggcgccc tgccgtcgcc tatgcatccg 3225061 cacagtctca ttacgcccct gtctggatgt acaggttcga ttggcacccg aagaagccgc 3225121 cgtacaataa agcgtttcac gcattagagc ttccttttgt ctttggaaat ctggacggat 3225181 tggaacgaat ggcaaaagcg gagattacgg atgaggtgaa acagctttct cacacgatac 3225241 aatcagcgtg gatcacgttc gccaaaacag gaaacccaag caccgaagct gtgaattggc 3225301 ctgcgtatca tgaagaaacg agagagacgc tgattttaga ctcagagatt acgatcgaaa 3225361 acgatcccga atctgaaaaa aggcagaagc tattcccttc aaaaggagaa taaatatggg 3225421 gaaaacagga tacattggtg ctgccattgt tgtggcagct tgtatcatta ttttgtcggc 3225481 cgtggtatgt ttacgggaca cagtctatta ccagcctatg cgctggactg gcatcatact 3225541 gtttttcgcg ggaattgtga tggttcccgc atactcagca aaaagaaaac ccggaaaaga 3225601 gaagtaattc tcttttccgg gtttttatgt ttattataat cttcccgcgc gaatatcgtc 3225661 tgtcattccc tcataaggag ccttcgaaat cacttcttcg ttgtcgactc cttcattttt 3225721 cagaaatgta atttccgcaa attcaggtac aacgtatttt ggatacgttt catatttttc 3225781 gcgggattct ttcatcaaat caatgtggtc attttggtag caaaccgtaa tttcaggatg 3225841 ttcatgcacc catttcggga agaaaataat gccatgcatg cgtttttcat ttggcataaa 3225901 gtttaatgaa acatccgtgc cagtcggctc tgtccaagac actttatata cgccttctgt 3225961 cagtttgaca atattcactt cctgatctcg aacccagcgt ccggcaacca ttccgctatg 3226021 aattctataa tcaattgtat ggtcgttttt aatataaatc tcgtattccc atccgttttc 3226081 atacgtataa atcatgtggc ttccgataaa gttttccatc ttacacactc tccttagtct 3226141 tttactgtac ttcataaatg tctagtagaa cgtaatcagg ggttctttct gcggaaccga 3226201 taaacaagcg gtcatggagc cattgataga cttcactgcc tgtttcaaac gtcggtaccg 3226261 tacgaaaata aacatgctcc ggttcaataa tttccccggc tgccgcttgt tttcgaaacg 3226321 gcttgctgac ttgccgtatt ccattgtttt caatgtaaat cagttcatga tctgctgttt 3226381 caatcacata cctggcagat aaatctgttc tgccgttagc gcgaatcatt tgtgaatcgg 3226441 caccgcccgg caaaatacgt ccctttactt ccccggttat tgttcccgaa cgaatcggaa 3226501 tgaatcatct cagtcccagg cttgtctcac caatcgtgat aggcggatca accttgattt 3226561 ctaaagaggc gaatggtttt aaaaccggct tcttcacgag aaccacctca ccttcagaaa 3226621 aaatcatgta actatttaca tgttcacttt aacaccattg cagttaactg tcaaacaata 3226681 ggaacataaa aaaacaagga ctgtttgaag acagtccttg tctgaagcta gctttgataa 3226741 gcaagatatg tgctgacagt gcttttggca agacaggcag aggaatctat aatcggaatc 3226801 tcactttgaa tatgatctaa caccgcattt aaatccgtgc aggctgaaat gatgatgtct 3226861 gcatgctgac tgatttcttc atatagcgtc tgccacaatg cttgtgtatg ctgcatatga 3226921 tttggctgtt tgattgcggc gataagctgg ttcacagcct gctgccaatg gtccttgtga 3226981 ataacttctt gtccatttcc cttcagaact ttttggtaga tggcggattg gatggttggc 3227041 tctgttccta aaaccaccgc tttttttgcg ggatgcggaa tctcttttat cgtttcctca 3227101 acaatatgca acataggaac tgacaatgcc tgctgaatct cttcatagta gacatgcgcc 3227161 gtattacaag gcagcgcaat gaaatccacg cctgttttct cgagctttac cgctccgtcg 3227221 ataatcgctt ttttcatctc gtcatggtca attggacgat ctgcatagaa gggcgtcggg 3227281 catgaataga tcatcatgtg cggatagtca atatcgtttg aagccccata cagcttctga 3227341 cagtaatcaa tcaccttatc aataaacggc gaggtcgatt tcggccccat tccggctaat 3227401 attccgatca tcaaattcat tcctttctac ttcgtacgga ccgcttcttc ctctgagcca 3227461 tcctcataga ggataaagct tttcgcagca tcctcaccta atgtaaactc gacttcaaca 3227521 gacaatgctc gcagaaagaa acgggtttcc gaggaaggaa ataactccag tctcagctgt 3227581 ccggcgatct ccaaataaag ccgttcattc tcggttgtca cctgtgcagc cgtcccatcc 3227641 tgcaacaggt agctgccaac atagcggctg tatatcgccg tatcaattgc ttttttcttt 3227701 ttatcagcag gacgttccgg gacatcatat ggctggccaa atagaatatg ttccgccgcc 3227761 ttcagaatcg cttgttcata ttcagtatcc tcttccttat tactcaaata gatcagcgtt 3227821 ttacgatgat cgatatatcg gatcatcatc gtcgaatagc cgggccatcc tccgctgtgg 3227881 ctgacaatcc gccctttttc aggactgttt tgcagcaccc agccaaagcc ataatcaatt 3227941 gtttctccat tgttgaggcg cactggagaa aacgcagatt ccttagaagc cttgctgatg 3228001 aaatcgtcct gatataaagc ctgatcaaat cgaaacaaat cgcttgtgac agagttaacc 3228061 gtcccatctc cctgtatgcc atcgagatac acaacatagt tcgtttcctc cagctcatca 3228121 gggaggacgt atgtttcgga atgtacatca tacacatatc catatgcata atgatcaatt 3228181 cgctcaggcg aaagcctcct gttatacact cttgtttcat tcatgcctgc cggtaaaaaa 3228241 atacttgttt ttataaaatc cgcatagctc atgccagatg ctttttcaat gataaccgcc 3228301 agcagcacat accccgtatt gctgtacatc cagccttcat tcggttcaaa ataaccagat 3228361 agcccctcat tcatcagcat atcgacaata tcctgattca ccgcaatctt gtgtgaatcc 3228421 caattggcaa aaaaccatcc catataatca ggaagccctg acgtatggtt caataaatgc 3228481 cgaatcgtta cgccctgata cggaaaaccg ggcagccagc gatccacttt atcctcatag 3228541 ccaagaatcc ccttctcctc cagcaagatg attcccaatg ctgtaaaagg ctttgacaaa 3228601 gacgctaact caaacaaaga gttggttttc aacgggcgtt tttccgtcat ttccgcatag 3228661 ccaaaagagt ggtgatataa aatatcgcca ccctccgcag ccagaaccgt cccgttaaac 3228721 tgatgttttt cgcctaatgt ctcaaataac gtctgaagat gctttctttt attctgcttc 3228781 attcctccac ctcccatatc tctgtacgtt actaacctac taacgtttca aatattttga 3228841 aaaatccttc agttagagat cctttttaac ccatcacata tacctgccgt tcactattat 3228901 ttagtgaaat gagatattat gatattttct gaattgtgat taaaaaggca actttatgcc 3228961 catgcaacag aaactataaa aaatacagag aatgaaaaga aacagataga ttttttagtt 3229021 ctttaggccc gtagtctgca aatcctttta tgattttcta tcaaacaaaa gaggaaaata 3229081 gaccagttgc aatccaaacg agagtctaat agaatgaggt cgaaaagtaa atcgcgcggg 3229141 tttgttactg ataaagcagg caagacctaa aatgtgtaaa gggcaaagtg tatactttgg 3229201 cgtcacccct tacatatttt aggtcttttt ttattgtgcg taactaactt gccatcttca 3229261 aacaggaggg ctggaagaag cagaccgcta acacagtaca taaaaaagga gacatgaacg 3229321 atgaacatca aaaagtttgc aaaacaagca acagtattaa cctttactac cgcactgctg 3229381 gcaggaggcg caactcaagc gtttgcgaaa gaaacgaacc aaaagccata taaggaaaca 3229441 tacggcattt cccatattac acgccatgat atgctgcaaa tccctgaaca gcaaaaaaat 3229501 gaaaaatatc aagttcctga attcgattcg tccacaatta aaaatatctc ttctgcaaaa 3229561 ggcctggacg tttgggacag ctggccatta caaaacgctg acggcactgt cgcaaactat 3229621 cacggctacc acatcgtctt tgcattagcc ggagatccta aaaatgcgga tgacacatcg 3229681 atttacatgt tctatcaaaa agtcggcgaa acttctattg acagctggaa aaacgctggc 3229741 cgcgtcttta aagacagcga caaattcgat gcaaatgatt ctatcctaaa agaccaaaca 3229801 caagaatggt caggttcagc cacatttaca tctgacggaa aaatccgttt attctacact 3229861 gatttctccg gtaaacatta cggcaaacaa acactgacaa ctgcacaagt taacgtatca 3229921 gcatcagaca gctctttgaa catcaacggt gtagaggatt ataaatcaat ctttgacggt 3229981 gacggaaaaa cgtatcaaaa tgtacagcag ttcatcgatg aaggcaacta cagctcaggc 3230041 gacaaccata cgctgagaga tcctcactac gtagaagata aaggccacaa atacttagta 3230101 tttgaagcaa acactggaac tgaagatggc taccaaggcg aagaatcttt atttaacaaa 3230161 gcatactatg gcaaaagcac atcattcttc cgtcaagaaa gtcaaaaact tctgcaaagc 3230221 gataaaaaac gcacggctga gttagcaaac ggcgctctcg gtatgattga gctaaacgat 3230281 gattacacac tgaaaaaagt gatgaaaccg ctgattgcat ctaacacagt aacagatgaa 3230341 attgaacgcg cgaacgtctt taaaatgaac ggcaaatggt acctgttcac tgactcccgc 3230401 ggatcaaaaa tgacgattga cggcattacg tctaacgata tttacatgct tggttatgtt 3230461 tctaattctt taactggccc atacaagccg ctgaacaaaa ctggccttgt gttaaaaatg 3230521 gatcttgatc ctaacgatgt aacctttact tactcacact tcgctgtacc tcaagcgaaa 3230581 ggaaacaatg tcgtgattac aagctatatg acaaacagag gattctacgc agacaaacaa 3230641 tcaacgtttg cgccaagctt cctgctgaac atcaaaggca agaaaacatc tgttgtcaaa 3230701 gacagcatcc ttgaacaagg acaattaaca gttaacaaat aaaaacgcaa aagaaaatgc 3230761 cgatatccta ttggcatttt cttttatttc ttatcaacat aaaggtgaat cccatatgaa 3230821 ctatataaaa gcaggcaaat ggctaaccgt attcctaacc tttttaggaa tattgctgtt 3230881 tatcgactta tttccaaaag aagaacatga ccaaaaaaca aaatcaaaac agaagccgga 3230941 ctaccgggcg gcatatcatt ttacgacgcc ggataaatgg aaaaatgacc ctcaaaaacc 3231001 gatctatttt gatggcaagt atcattattt ctatctatat aaccgggatt acccaaaagg 3231061 caacggcaca gaatggcgcc atgccgtctc agaggatttg gtgcactgga ccgatgaagg 3231121 cgtggcgatt ccgaaatata caaacccgga cggtgatatt tggaccggtt ccgtcgtggt 3231181 ggataaagag aacacagccg gcttcgggaa aaatgcgctt gtcgcgattg tgacacagcc 3231241 ctcagccaaa gacaaaaaac aggaacaata tttgtggtac agcacagata agggaaaatc 3231301 attcaaattc tacagtggca accccgttat gcctaatccg ggcacagacg atttcagaga 3231361 tccgaaagtc atatgggatg accaagataa caaatgggtc atggtcatgg ctgaaggatc 3231421 aaaaatcggc ttttatgaat ccgataatct taaggactgg cattacacaa gcggattctt 3231481 cccagaacag gcgggaatgg tggaatgtcc cgacctctac atgatgcggg caagcgacgg 3231541 aacgaataag tgggttctcg gtgccagcgc gaatggcaaa ccgtggggca aaccaaatac 3231601 gtacgcctac tggaccggaa gcttcgacgg aaaagaattc aaagcggatc agactgaagc 3231661 ccaatggctt gactatggct tcgactggta tggcggtgtg acgttcgaag acagcaaaag 3231721 cacagatcca ttagaaaagc ggtatgcgct tgcctggatg aacaattggg attatgccaa 3231781 caacaccccg acaatgaaga acggctttaa cggcacagat tctgtcatac gcgaactccg 3231841 gctgaaggag caggatggaa catacagcct cgtctcacag ccgattgaag ctttggagca 3231901 gctgactgtt tcaactgacg aaatagagga tcaggatgtg aacggatcaa aaacattgtc 3231961 gataacaggt gatacgtacc agcttgatac ggatctttct tggtcagagc taaagaatgc 3232021 aggcgtcagg ctcagagaat cagaagacca aaaacgccat attgatgtcg gcattttcgc 3232081 tgaaggcggc tatgcttatg tcaatagagc agccacaaat cagcctgaca aaagcaatac 3232141 ctatgtcgaa agcaaagctc cttatgatgt aaacaaacgt aaggtgcatt tgaaaatact 3232201 tgtcgataaa acaacgatag aagtatttgt tggcgacggg aaaaccgttt tttcaaatga 3232261 agtcttccca aagcctgaag ataaaggaat taccctttat tctgacggcg gcacagcctc 3232321 cttcaaaaat ataacagtga aacactttga ttcgattcat gaataaaaac aggggcggcg 3232381 caggctgccc ctgttttttt attaggagcg gtattctctg ttacatattg ggcattgtaa 3232441 ggaatataag gctggtttca aaggaggaag cgaatgtcta aacaaggaaa ttttcaaaaa 3232501 tcaatgtcgc tgtttgatct gattttgatt gggatgggag ccatctttgg atcagcgtgg 3232561 ctgttcgctg tcagtaatgt cgcttcaaaa gcagggccct ccggcgcttt ttcctggatc 3232621 ctcggaggag ccattatttt gttaatcggg cttgtatatg cggagctcgg agccgctctg 3232681 ccccgtaccg gaggcatcat tcgatacccc gtttattcac atggccacct tgtcggctac 3232741 ttaatttcgt ttgtcacgat tgtcgcttat acaagcttga tttcaattga agtgacagct 3232801 gtgcgccagt atgtggccta ttggtttccc ggcctgacca ttaaagggtc tgattcgcct 3232861 accatttccg gctggatctt gcagtttgcc ctattatgct tgtttttcct gctgaattat 3232921 tggagcgtca aaaccttcgc taaggcgaat ttcatcatat cgatttttaa atatattgtg 3232981 ccgattacca tcattattgt gctgatcttt cattttcagc cggagaattt atccgttcaa 3233041 ggatttgcac cgtttggatt tacaggtatt caggctgcca tctcgacagg cggcgtcatg 3233101 tttgcgtatc tcggcctgca tccgattgta tctgtagcag gtgaagtcca aaatccaaaa 3233161 cgcaatatcc cgatcgcttt aatcatttgc atcatcgttt caaccatcat ttatactgtt 3233221 ttgcaggtca cctttattgg tgcaatcccg acagaaacac tgaaacatgg ctggccggca 3233281 attggccggg agttctcatt gccgtttaag gatattgcgg tcatgctcgg gttaggctgg 3233341 cttgcaacgc ttgtcatttt agacgccatt ctgtctcccg gaggaaacgg gaatatcttt 3233401 atgaatacga catcccgcct tgtttacgcc tgggcgcgta acggcacatt atttggcata 3233461 ttctcaaagg tcaataaaga tacggggaca ccccgcgctt cgctttggct ttcgtttgcc 3233521 ctgtccattt tctggacact tccctttcct tcgtggaacg cgctcgtcaa tgtctgttca 3233581 gtcgcgctca ttctttcata tgcgattgca cccatttctt cagctgcgct gagggtcaac 3233641 gcgaaggact taaacaggcc gttttattta aagggaatga gcattatcgg gccgctttcc 3233701 tttatattta cagcgtttat cgtgtactgg tcaggatgga aaacagtctc ctggctgctc 3233761 ggttcacaac tcgtgatgtt tttgatctat ctctgtttca gcaaatatac gcctaaagaa 3233821 gatgtcagcc ttgctcagca gctgaaatca gcctggtggc ttatcgggtt ttatattatg 3233881 atgctgatct tttcctacat cggttctttc ggacatggtt tagggattat cagcaatccc 3233941 gtcgacctca ttttagtcgc gatcggctca cttgcgattt attactgggc aaagtatacc 3234001 gggctcccaa aagccgccat tgattatgat aaataaagaa gcaagaggtt ttcttgcttc 3234061 tttattcttt acaaacaaac atacacgcga taaaatgaat gagagtcagt cattactgga 3234121 ggtgttcctc atgccaaaac aaacatcggg taaatacgaa aaaatattgc aggcggccat 3234181 agaagtcatt tctgaaaaag gcctcgacaa agcttctatt tctgatattg tcaaaaaggc 3234241 cggcactgcc caaggaacat tctatttgta tttttcatct aaaaatgccc tcataccggc 3234301 cattgcagaa aatctcctca cccatacact tgatcaaatc aaaggtaggc tccatgggga 3234361 cgaggatttt tggaccgttt tagatatatt aattgatgag acatttctca ttacagaacg 3234421 ccataaggat attattgtcc tctgttattc cgggcttgcg atcgaccact ccatggaaaa 3234481 atgggagacg atctatcagc cttattattc ctggcttgaa aaaatcatca acaaggccat 3234541 tgcaaaccat gaggtaacgg aaggaatcaa ttcaaaatgg acggccagaa cgattatcaa 3234601 cttggtcgag aatactgcgg aacgattcta tatcggattt gaacaagatg aaaatgttga 3234661 agtgtataaa aaggaaattt tcactttctt aaaacggagc ttaggtactg cttaaaaaat 3234721 gactgggtaa caccgctcat tttttaatgc cctaaaaatg actgacgttc attcataaaa 3234781 tagagaggtg tttcatttga attgggttct tgtttttatt gcagggcttt tagaggttgt 3234841 ttgggcctct tccctcaaac atgccgattc gcttttggat tggatcatca tttttatctt 3234901 aatcgcggtc agctttatcc tgttgatccg ctcttatcaa aaaatcccga tggccgcggc 3234961 gtacactgtg tttgtgggaa tcggaaccgt cggaacatat ctgactggaa ttgttctggg 3235021 cgaatccttc tcagcagccc aaatgttctt tttagcttta ttgctggctg gcattttagg 3235081 aatgaaatta tttacgaaag aaagcaaatc tcagccggga ggtgaaaaat aatggcatgg 3235141 tttttattag tgattgccgg catagaagaa attatagctg ccattgccat gaaatatata 3235201 gacggaacaa gaaaaaaatg gccgatcatt gtgatgactg ttggattcgg cttatccttt 3235261 tactgcctgt cccaagcgat gatcgtcctg cctgccggag tcgcatatgc cgtctggact 3235321 ggcattggaa gcattggtgt ttcggcggtc gggctcatct ggtttaagga gcggtttcag 3235381 ctttcacagg tgatttcact ttgccttatc ctagccggcg tcatcggcct gcgtcttacg 3235441 tcatcttcat aaaatcaagg catatacagc tgtatatgcc tttgccatta agcttcgtga 3235501 tgtttttgaa gatgaagcgg cggcgggatg agccagcctt tgttttttag cagccttaag 3235561 tattttgcgc cggttgccgc tttcgacata tgaaattgcc caaacatcat ggcaatatcc 3235621 tcacgaatcg attgccccat cattttgctg catgtcacaa gacctgcagc attttctgct 3235681 gccgcggaag ccgccacatc cggatcgaga aaccgtgcac caggcggaat atcgttaaga 3235741 tctgctgtcg gcggttcagg agaagccggc ggcagcgcca ccccgttttc tttcaggatc 3235801 gtgctgacct gtttgatttc atcttggcat ttctcaatag actcacgaag cagcttcttc 3235861 aggtcgtcat caccgacatg attcaatagc atttggtaat tgccgaccat tttattgccc 3235921 gccatcacat aactccacaa gccgaatacc tcaccgtaat gcatcggttc atcctgcgga 3235981 tttccgctta aaatacccat gctcattctc ctcccatatt caatattgca catttcataa 3236041 cgtgcccaag cggaggaaca tttatgtttc agcggaaaag atttatgaaa tgaaacaaaa 3236101 caaaaaagac aagagtggca agttgccaaa ccattgtctt tcctgttgtt tgattggacg 3236161 cactgaaggg attcgcaccc cgacagacaa gataccggaa accattcaag tgctttttag 3236221 tatgagtcat tgattctgtc tttaataaac tttaacgaga tggcgggatg ctttgcggaa 3236281 aacgaaatac attttcgggg tcatatttcg cctttatttc tcgaagccgc gcaaagtttg 3236341 cgccataata ttcttttccg aagttttcaa tgttttgatc tggaacatta acatatgaac 3236401 ctgctacata tggttgcatc agctgacgca ctctttcaac tgatgcaaga tttgaatctt 3236461 cttgtgattt atttttccaa ctagccgtcc attccgtata aaataatgga tggcgccaaa 3236521 aaaaggcagt ttcgtcttta gggactctgc ttatagcacc accccaattg ataaaaaaga 3236581 aattggcttc tgttccagta gcatcttcca aaaattttct catgattgaa atgggttcgt 3236641 cagaccaaaa atcatgaccc catgccgagg agaatttaac actctgatca tttctgccag 3236701 ggatgggttc gtcagggtct aagaaatcta tagcatctgg atagtataat gttttgatat 3236761 ctgcttctgt tggagttccc gcatgtaata aaggttttaa taatcgaatc aattcagttt 3236821 tcgaaccgag gaaaattcct tctgcatgac acaaaccatt tattttgctg taaatttcaa 3236881 ggtagcatcc taatcgttca tctacaaacg gagcccattt ctgccaagct ttaaataccg 3236941 tttctaattg ttcccacggc cagataatat tgaagacggt tgcagtttta ggggcacgat 3237001 gaactttgaa tgtatattgg gtattatatc caaagttacc tcctcctccg cctctagaag 3237061 cccatagcaa atcctcattg tgagattgat ctgcgtgaat aatccttcct tttgcatcta 3237121 ccgttttcag cgcgagaagg ttatcactta taaggccaat cgatcgtgag agtacaccaa 3237181 atccgccgcc catcgtaatt cccccgattc caactgttgg gctatctcca aacggagcca 3237241 taaaaccgtc tcgagctaat ccctttacaa gcgggccaac gggaatacca gtttgaacgg 3237301 ttgcaatagc gttttcttca tctaagaaaa ctttattcat gtcactcaca tcaataacaa 3237361 ttcctccact tactactgaa aggttcttat ctaaagcatg gcgaccgctt ctgacacgta 3237421 agggcacttt attctcacga gcccatttaa tggcattact tacatcgtat gaattttgcg 3237481 caaaaacaaa gacaagagga tagacatcca cataagggtt ccaattctta atagcctctg 3237541 tatagccggg gtctcctttg aagattacac gccctgtcaa ctgtgttgat cccatatatt 3237601 atttcactcc caaagaaatt cgattcagat actaaaatat gcaggagctg gataatcgca 3237661 tagacaaatg atctacgaac tataaatata atacgctaag gcctttttcg tcggtgaggt 3237721 ctgctgagaa acatttttca aacaattttg agcaaacttc ctgtccaatc ctccaacaag 3237781 cgttttttct tatcgttttt aggagcagtg tccagttttt ttcggagtga atattcgttt 3237841 aggccaaaag aaaagagaga tgaagaagtg tttagtacca gaggtataca tccatacaac 3237901 agactctaga tcatcatata ctgaatgtat gtagaaagga gacatcagct ttggcaaaat 3237961 atcggattat gacctttgac ggcggcggta ccttaggtgc tttaagttta caactattaa 3238021 acagattggc taggcaaaac ccgaagttaa ttagtcgaac ccatgtattt tcgggaaatt 3238081 caatcggttc atttactgcc cttgcattag caagcggaag atctccgagg gaaacacttc 3238141 agtattttga ggatgaaatc ctacccgcat tcagcatttc ccggccaggc ggacctgttt 3238201 tcaaccaaca attaccctat tccggtttta ttaaagcggt aagaaatttt ttcccagcag 3238261 atcttcaact tatagattta agaaaacgaa ttgttgtccc atcattcaaa ttatactctc 3238321 aaaaactgga ccgttggact cctgtcttat ttcacaattt tcccggctct ccctatttaa 3238381 atgaaaaagt gagtgatgtc atactgcgga gcagcggtgc tcccgcgacg caacgcgcct 3238441 atcaaaacta tgtggacgga tatgtagtag caacgaatcc cagtacagcc agtatcgcgt 3238501 ttgcagttgg taaagccaac gtgccattgg atcaaattgc ggtattgtcc atcggaacag 3238561 gtgaagcccc gactcggtta agaagagata cgaggggatg gggaatggta agtgcagata 3238621 acatacgtcc cgaaaatctg aagaaccttc ctccaaattg gggagtcctt ttggacaggt 3238681 cgcctaatga acctttactg ccatttcttc agatgattgc tggcggtaat gggtactatg 3238741 aatccatggt cagtgcgaat cttctgggag atcgtttttt ccggttagat ccgcggattc 3238801 cgaacttctc caaaacggac cctgccgtcg ttcccgctgt cattgaaatt gcgaacaaaa 3238861 caaacttaca gcctgcgaat caatttatag agaagaactg ggggagcaaa taattattta 3238921 ttttaaatca attctcgctt atacaatttt gtccgagaga agattctcaa aataaataca 3238981 ggcaatgggt agaaccggat ttttttaaag gtttgttaat cacaagctaa taagatgaat 3239041 gaaaaaatca attcatactt cttcttttga aagtgagggt tcaaactaaa gaatgtaatt 3239101 gaaatgttac tctaaggtat gcaattccct ttttcacaca aaaaaagaca agagcggcaa 3239161 atcgccaaac ccttgtcttt cctgttgttc tattggacgc gctcggaggg attcgaaccc 3239221 ccgacagacg tggtaccgga aaccaccgct ctatccaact gagctacgag cgcatataga 3239281 ctgcgttatg agaacgtcag cacaactaat tatacgataa ttcctttcaa ataacaaccc 3239341 tctatttcga gaggccgttt tttaaataga caaagcatct taattggcaa tctgacatac 3239401 gatggtttga acccctgtat ttttggggaa aatgggaaaa agagacgact ttgcatatca 3239461 ggccagcttt ttgtttgacc tttattgacc aaaaatgtat catgtaacta catacttacc 3239521 taaaaggtga aggaggagca ttatgaattt aatacctaca gtcattgaac aaacgaaccg 3239581 cggggaaaga gcgtatgaca tttattctcg tctattaaag gatcgtatca tcatgcttgg 3239641 atctgcgatt gatgacaacg ttgcgaactc catcgtgtca cagcttttat tcttagcagc 3239701 agaagaccct gaaaaagaaa tttctcttta catcaacagc ccgggcggct ctattacagc 3239761 cggtatggcg atctatgata ccatgcagtt tattaagccg aaggtatcta caatttgtat 3239821 cggtatggct gcgtcaatgg gcgcgttcct gcttgcagcc ggcgaaaaag gcaaacgcta 3239881 tgcgcttcca aacagtgaag tcatgattca ccagcctctt ggcggtgcgc aaggtcaagc 3239941 gacagaaatt gaaattgctg cgaaacgcat tctcttgctt cgcgacaaat taaacaaagt 3240001 cctagctgaa cgtactggcc agccgcttga agtgatcgaa cgcgacacag accgtgataa 3240061 cttcaagtct gctgaagaag cgcttgaata cggcctgatt gacaaaattt tgactcacac 3240121 agaagacaaa aagtaataac acaacctgca agagctgcgt ctcttgcagg tttttttcat 3240181 ttcaaggaat tgactccctt attctatact gctcccattc ctcatgtaac agctcaagcg 3240241 tcaaatcact cgtctgcctc acaaccagat cagcaccaag catcggctgt ccttgaccga 3240301 caccaaccgc aaacatcccc gcagatttga ttgcagaaat gcctgcttct gcgtcttcta 3240361 ttgccgcgca atcagcaggg gaaacatcga gcatcgctgc agctgttaaa aagatgtcag 3240421 gatcaggctt ccccttcgca agagtcgtcg gatcaacaat ggcatgaaaa tcatcgataa 3240481 ttgccaagcg tcttaaaatc ttaggagcat tgcgacttga agatgctaac ccgattttta 3240541 tattttcgtt tttcaattga catagaagcc tgccaatccc cggtaaaaga tcttccggcg 3240601 tcaatttgct gatcagcatt tgataatcgc gatttttccg atgcataagc tcttgtttct 3240661 ccgcatttgt atactttgtt tccgccccgc caaagatcaa tatgctttca agtgactctt 3240721 ctctgctgat tccttttagc ctttcattca tgtctctgtc aaaagggata tcgatttgtt 3240781 ctgcgatgtg cttccaagcg agaaaatgat attcagcagt atctgttatc actccgtcta 3240841 aatcaaaaat gaccgctttc atatactaat gcccatcaca gcttcataag gtttgaggct 3240901 aatactcttt aagtcagccc gctcctgcgg atagtttgaa attagcactt tccaacgctc 3240961 atgaatcagt tctggaggcg cttcgaacag agccttttct tccgataaat tcacaacgac 3241021 aagaagcttt tcccctcgat attctcgaag gtaagaaaag acctgcggat cattctcctg 3241081 caacagctga taatcgccat atatcataat cttatattgc tttcgtaatt gaatgagctt 3241141 ctgatagtaa aagaaaatcg aatcttgatc ttccaaagac tctttcacat tgatatcttg 3241201 atagcgggaa tttaccggta tccacgggtc tccggctgtg aatcccgcat gttttccggc 3241261 atcccactgc atcggtgttc tcgcatgatc ccttcctttt atcatcacgg ctttgacaaa 3241321 ctctttttct gacatcgttt tgttttcgac gactagttca cgatatgcat tctttatttc 3241381 aagatcatca tacatctcca gcggcatatc gctgttgacc atgccgattt cttctccctg 3241441 gtaaataaac ggcgttcctt tcatgccgtg cagaaccgtt gcaaatgcct tcgcacattc 3241501 cttacgcagt ttcctgtcat tgccccagcg ggaaataacc ctcggctggt catggttctc 3241561 aaaataaagg gtattccagc cgacattcat taacccggtc tgccaccttg tcatcgtctt 3241621 ttttaaagca atcaaatcaa acggcttgat ctgccatttc ccatttggcg agttttgttc 3241681 tttatcaata tccatatgtt caaatgtaaa gatcatattc agctcttgcc tgcttgcatc 3241741 tgtgtacttt ttcgcctctt caatatcaga gccgtttgcc tctccgactg tcatgcagtc 3241801 gtaatgagaa agcacttccc tgttcatctc ttgaataaac tcatgaagac gtgggccgtt 3241861 agagtgataa cggccgacaa tatagctgcg gctgtgatcc gtttcgtagt ccggaaaatc 3241921 ggtgtattta gaaatagagc caatcacatc catccgccag ccgtcaacgc ctctatccat 3241981 ccagaatctc attacatcat aaacttcccg gcgaacggct tcgttttccc aatttaaatc 3242041 aggctgtttt ttcgaaaagt agtgcaaata atactgccct gttccttcat cgtatgtcca 3242101 cgctgagcct gaaaagatcg atccccaatt attcggctct gagccgtccg gtttaggatc 3242161 tttccaaaga taataatccc ggtaaggatt gtccttcgac ttgcggcttt cagcaaacca 3242221 agcatgctca tctgatgtgt ggttcacgac caaatccatg acgattttca ttccgcgttt 3242281 atggacttca tcaatcagct gaaacatatc ttcatttgtc ccaaactttt cgtacatgtt 3242341 tttgtaatcg ctgatatcat atccgttgtc atcctgcggg gaatcaaata ccggggagag 3242401 ccagatgaca tccgccccga ggtttttgat gtaatccagc ttttgaatca caccttgcaa 3242461 atctccgaat ccatctccat tggcatcata aaaactgcgc gggtaaattt gataaacgac 3242521 agcttctttc caccattcac tcattaggcg ttctcctttc acatcgtccc tgtaggacaa 3242581 ccggttcctc ataaacgttc atgtgcagcg gctcgccttt tacaagctca aaaataacgc 3242641 gcttttcgtc aaccgtcaca ttgattaatc gatttcgata attgatgttg aatgaatatt 3242701 cgtcccattc tttcggcaaa aacggagcaa atgacagcgt ctcattcgcg gtgcgcatgc 3242761 ctgcaaagcc atgaacgatt gccagccagc tacccgtcat tgaagtaata tgcaagcctt 3242821 cttccgtatc atgattgtaa ttatcaagat caagccttgc tgtgcgctta tataattcga 3242881 gcgctttctt ttccagcttg agttcggctg cgagaatcgc atggacagag ggcgataggc 3242941 ttgattcatg aacagtcatc ggctcataaa attcaaaatt tcgccgtttt tcttccattg 3243001 taaaacggtc attaaaaaga taaatgcctt ggagaacatc tgcctgctta ataaaattgg 3243061 agcggagaat cttgtcccat gaccaattct ggtaaagagg ccgttccgct ggatctaatt 3243121 cgtcaactgt ttgcaggtct ttgtccaaga acgtgtcatg ctgaacgaaa atttgcagtt 3243181 cttcactaaa tggatagtac atgtgctgga tgatttctct ccagacttcc aattctactt 3243241 cctgcacatc cagatggcgg cgtttctccg ctgagatact ttcgagactt tgtagagtat 3243301 actccaacgt ccaagccgca atgacattcg tataccaatt gttgttaacg ttgttttcgt 3243361 attcattcgg ccctgtgacg ccatggatca tatacttatt ttttcgtttc gagaagtgaa 3243421 cacggtcggc ccaaaatctg ctgactgcca caagtacgtc tatcccgtat tcttccatat 3243481 agttacggtc gcctgtataa ttgatataat tgtagatcgc ataacagatc gcgccattgc 3243541 ggtgaatttc ttcaaaggtg atttcccatt cgttgtggca ttcatcacct gtgaacgtca 3243601 ccatcggata aagtgccccc ttcatcccca attttgcagc gtttcgtttg gcagcctcca 3243661 actgatgata gcgatacaaa agcaggtttt tcgtcacctc cggctcggct gtcgccaaat 3243721 acatcggaac ggcgtacgcc tcagtatccc aatatgcggc acctccatat ttctcgccag 3243781 taaatccttt cggcccgata ttcaaacggg catcgccccc gtaatatgtc gagaataact 3243841 gaaagatatt gtagcggatt ccttgttgaa gctcctcatc tcctttaatc tcaatgtccg 3243901 cttttgccca tctttccttc catcgatcag tgtgcctccg ttttgcatct tcatagccgt 3243961 tctctaccac atccgccaaa agctccttgg ctttcgataa aagctcttcc tcccgaaaat 3244021 cacgggaagt cgtgacaatc acaaactttt tcaatgatgc cttcgtttga taactgtagc 3244081 gattctcgac atacatttca gtcgttttaa agctttcatg gacaaaaccc tccgtctcgt 3244141 ttgccattgc ggctaatacc gtgaagcgcg gtgttccaaa tggattttcg atcgtttttg 3244201 ccgctaaatg gccgctgtga gaatcagcac ctttcgcttc ctcctgccaa aactgttctt 3244261 ggtagttaga atcttcattt gccacatttc catccaggta aggaacaagc gtaatgacag 3244321 catctcccgt caagcactcc gcttcataat gaatcgcaca gagttctttt acagcaaggc 3244381 taagaaaccg ctctgacctg attctgacgg ttttatcttg aatgcggaca acagcgcttc 3244441 gccgcagaat cccctctttc atattgagtt ctacctcaaa taattcgatt gggttttgat 3244501 ggagatcgat tttttcaccg tcaacatata ggcctatgcc cataaagttc atcgcattga 3244561 tcacttttcc gaaatattct ggatacccgt ttttccacca gcctactcgc gttttgtcgg 3244621 ggaaccacac gcctgcaata tatgtgcctt ggtgactgtc gcctgaatag ccttcttcaa 3244681 aattccctct gacccccata tagccattgg caagagacgt caggctttcc agcagccgtg 3244741 tatgctcctt attaaatgta tttgttttga ttttccattc atcaatctca aataaccgct 3244801 gatttatcat catttcctcc cgaatgtaag tttccattat cacggcgggt tttggtcaaa 3244861 tatctaaatg caaaagagat catcaaagta acgccacacg aatggatcat caatacagta 3244921 atcaaatcaa aatgaaccat gccgatagca gctgccgcaa atgccggcag tgctgatgcg 3244981 caaatcgcta tagaggccgc ttccttgaat gatgcaatag agaccatgtt tgatattttt 3245041 gtgatccaga ggccacctgc aagaacaaac gttaacaaaa gctggatcat agaaaccacc 3245101 gtatatgcca gcatcatgat catcggctta tactgtgcca accacaatgt atcgatcaag 3245161 acctctacat catggacgtt tggtttctcg agcttaacgt ccattttcgc atagccaaca 3245221 gaaaaccccg tttcgttttg atcggtgatc accagttgat caggttgaaa tatgatggcg 3245281 ttttcaaatc cagttacttt caatcgccca ttttcaccgc ttgtctcata ttcatgcttc 3245341 atatcgactg ccatcacatt ctgcccatct tcaatcctct cagagctctt cccgcctgtt 3245401 agttttccgt tcctgatttg aaaaccctgc aattgatcag caaattgatc attaactcct 3245461 tgaatcgctg acggcatgaa agatgaaacg ctgaagcgat ccattttcac aaacgaaacc 3245521 gctaacggcg ccattaagca ggccgttaaa aacagaaaga gaaaagagag ctgcagccag 3245581 ctgaaggtat tcccatagcg gcaaacacct gatggggatg cagccgcctt caggcagcgg 3245641 atgataaagc ttttattctc cagattcttc attggcatta cccctttgtt ccgccggctg 3245701 tcaaaccgga cacaaagttc ttttggagaa aaaagaatag aacgcatatc ggcagtgcgg 3245761 ctagtatggc accggctgca aatagagcta ctttttgctg ctgcggatta gaaataaagg 3245821 attgtaatcc tacagcgatg gtcagccttt ccggtgagcg aagcagaaat ttcgtcagca 3245881 aatagtcgcc aaacggtgcc ataaacgccc aaagcgcttg taccgcgagc attggcttaa 3245941 caagcggtag aacaattgaa gcgaaaatcc tcagatgtcc cgctccgtca attcgcgcgg 3246001 cttcatcaat ttctctcggc acagtatcaa aataaccttt catcagccac gtgttcatcg 3246061 gaattccgcc gccgatatag atcgctgtta aaaaccagta ttgatcgagt gcgcctatta 3246121 gcatcgccaa gacataaaaa gcagtcagcg ccgccattgt cggcaccatt tgaatgatta 3246181 aaaagaatat caggctcttt tttctgcctg caaaccgata gcggctgtac gagtacccgg 3246241 caagtgtcac aatcgtaacc tgcaaaacca tgaccgatag cgcgatgaca agtgtattgc 3246301 tgtaccaatt gagataaagc gtttcgtcaa atagccgctt aaaatgatcc aatgtccaag 3246361 aacccgaaaa atcgagctga aaagccgccg aattccccac acggaaggct gatgatgccg 3246421 taatcagcaa cggatatata atgacaatac ttaaaagcgt caaaaataaa tacgtacaga 3246481 ttttattaag cattctggca gtgctcgcgt tcacctacat aacctcctca ttgccaaaag 3246541 cattcgattt tttgaaagca atcagtgaaa ttccaatgac aatgaaagaa attaacagtg 3246601 tcacagccgc cgcaacggaa tattggggtg atgtgcctgt tgtcagttta taaatccacg 3246661 aaattaagat atcggtcgat ccggccccgg ctcccgcact gcctggccct ccctcattaa 3246721 ataaatagat gatcgagaaa ttattgaaat taaacgtata ctgagtaatc atcacgggtg 3246781 ctgtggcaaa taaaatcatc gggaatgtaa tatgccgaaa acgctgaata aaagtggccc 3246841 cgtcaatctt tgccgcttca tacaattcac ctggaatcgc ctgaagcact cccgttacca 3246901 tgacatatat atatggaaag ccgagccacg tttgaatcat aatgagggct gtctttgtcc 3246961 agaaaggatc ggtcttccac gcgatcgcag gcagctcgac aaacggcagg tgattgaata 3247021 atggtatcac ctgtgcattc accgctccta tgctgtcgtt aaacatgttg gaaaaactca 3247081 tgattgtaat aaacgccgga acagcccatg gaaataagaa aatcattcga aatatccgct 3247141 tgccttttat aaaatcctga ttgacgaaaa gtgccgtcac aatacctaaa atgatttgca 3247201 gcgttgttgc acagattgtc cagataaccg tccagcccag tacattcaca aatgtttcac 3247261 gataggagcc aaggaaaaaa atatttaaga aatttttaaa cccgacccag tcaatcagac 3247321 gattaggcgg aatatgataa aaatcatagt ttgttaatgc aacaaacaga gtcaccaaaa 3247381 ccggaaaaat aatcacaaac accatcatga tatatgccgg cagtgtaaat agatacggaa 3247441 aacctttatc gcccgcatga cagatcatat ccttggctgt tgtattgact tccaaacccg 3247501 ccgctttcat agcggcggtc ttacgtgaat catgaatatt aaagatatag aacatgagga 3247561 aaatcattgt cacgatcaat tgcagcgtgc cttcaatcag cataaacagc gagtgatctt 3247621 caccgggaac acttcccaat gtcatcaatc cggttagcgc ctgtataccg aaaacgcata 3247681 attcaaaagc aaacaagcct gtgatggcaa gaaataagag cccctttgac aactgctgat 3247741 tcgcaatctg cccaagtcct ggaatgatcg ataaaagccc tgcctttcgt ttttgctttg 3247801 taagtgtgtg atgtttattc atttttccgc cctctattct tccggacgct atcccgccgt 3247861 tttatttcac atacttttct ttaatatttt cctttatgac gtttacagca tcattcgctg 3247921 atgtttgtgt cgattttttt cctgaagctg catcaaaaat taaactttcc gctcctgtcc 3247981 atacttcagc catttccgga atatttggag tcggcgttgc tgtttcatat tgtttaatca 3248041 cagctgacgt cagttcattc ttttgctcat cggctttctt ccttgcagcc gtgttggccg 3248101 gaacttcgtt tgtatcctca taaaaagcgt aagcattggc atcatttgca gcatactcaa 3248161 gccatttttc agccagctcg ggctcttttg tatatttcga ggcaacccag cccttcccgc 3248221 cagcaaaagg ggcgtattct tctccatttg gcaatgtcgg aatgggagcc gctccgtagt 3248281 tcaatttagc ctctttatag ttggcagctg accaaggacc gccaatgatc gcagccgctt 3248341 tgccttctaa aaacatctgc tgaataaagt cgtctgcgct tgaattgtct tgcattcctt 3248401 tcggccaata tgtctcaaac catttctccg catatttcac cgcttctaca gcccctttat 3248461 tgttcaggcc gatgtccccg gaatctgtgc cgttttttcc aaacacatat ccgccgtatc 3248521 cagccaataa gccgtacgac atataaaagt cagtccattt tgctaaaaat ccggttgatt 3248581 ttcctttttc cgaagcaaac gcgaatcgag gatcttccgt taacttttca aggtctttaa 3248641 atgtttttgg cgctgttttt aaaagatctt tgttgtaata caaaataagt gtctcaatga 3248701 ctagcggcat tccgtacact ttgccgtcaa ctgtcacctg ctgcatttct ttatcaccaa 3248761 agctttttgt gttagatggc ttaatatcaa gtaaatgtcc ttgttgtccc aaaccgccga 3248821 tccggtcata tgcagcaagc ataacatcag gcgcattacc cgccgggcca tcaagaggaa 3248881 gcgcttctaa ctgttcgaac atttgctttt caacaatttt tactgtgaca tcattttctt 3248941 tttcgaactt tgtttttatg ctttcaatgt attctttata cgtttcttcg acagacacag 3249001 tcagcacctt tttgccatca gagcttgctg gattttttga acttgagcag gcggcaaggc 3249061 cgattgccag gaatgatgcc gccaatatgg cgaacccctt ttttaaaaga accatctctt 3249121 ttcctccttc tatttacgaa actataacaa ttgtattgtc ctatagaaag cggttacaac 3249181 aactttcgat ttgttaccga taacagaatg ttatacaggg gcggcagcac tcaaaatcaa 3249241 aaattctccc ggctgaacgg caatgacatc gtgatgctgt agcggctgct ctgtccatgc 3249301 atcacagatt ttcttattcc tatcaatatt caactctcgt aaactgacgt gttgaaccac 3249361 attcccttga ttaaagaaat aaatcagtat tttttcatca agagtccgcg aaaagctaat 3249421 gaaatcattt ttgtcgtcca gcagattcca ctcaagatgt ccttcagtca ataaagtgtt 3249481 ttcctgcttg cgtaaagcaa ttaaccgttt cataaattgc agcatgtctt ggttttgctt 3249541 ctctttttcc caaaccatac atttccggca taatggatca ttttcgccgt tcagcccgat 3249601 ttccgttccg taataaatgc atggtgagcc tgtctgggca aacataaagg ccagcaacgc 3249661 gcgtgctttc ttctcatcat tgcggcatct ggtcaaaagg cgctttgtat catggctatc 3249721 cagtaaatta aacatcacct cattggcctg cttcattcca ttcatcaaat gtgcattgac 3249781 acggtgagcc atacgtgaag ctgagatcgt ctggtcagca aagtattcaa tcataggctc 3249841 tgtaaaaggg taattcatcg ccgcatgaaa ttcatcccct ctaagccagg gttcggcaga 3249901 atgccagatc tcacctaaaa tataaacatc aggcttttca gtagatacag cctgcctaaa 3249961 tgtcttccaa aaaacgtgat ccacttcatt tgcgacatcc aaacgccagc cgtcaatgtc 3250021 aaattcgcga atccagtaca aagcaatatc aagcaaatat ttctgcacct cgggattagc 3250081 cgtgtttagc ttcggcatat cagctgtaaa agcaaatctg tcataattgt cgtctgtgac 3250141 gggaaaagag tgaatatgga accagtcctt atagcgggat tgatctccgt ttttgacgac 3250201 atcctgccat tgcggagacg cgcttcctat atggttaaaa accgcatcaa gcataattct 3250261 catcccccgc tgatgcagct ggctgaccaa tgtacgaaaa agctcaggat ccccgaaatg 3250321 cggatcaata gaaaagtaat ccagcgtgtc gtatttatga ttagaaggcg cggaaaagat 3250381 cggtgtcaga taaatgccgt tcacccctaa atcctctaaa taatcaagct tgtcaacaat 3250441 tccttgtaaa tcccctccaa aaaaatcatt gacgtccggg tccttgctcc cccacggcaa 3250501 tgcattcttc ggtgacaagt cttctcttcc atttgcaaaa cgctccggaa aaatttgata 3250561 ccaaaccgtt gacttgaccc attcaggcgc ttgaaatgta tcagcctcgt gaacaaacgg 3250621 aaatttaaag taataatgaa tcgtttccag tgttttttcg ttataagggc atacacccga 3250681 acttccgaaa aagatgtctt catgatcgtc tgttacaaca aacgcatatt gtaaacgcct 3250741 aaatggcggc accacttcag caaaccaata gtcatgcatt tctgtagcag caattttcct 3250801 catcggctgc tcgtttgccg accatttgcc gtcgttgtac tcatagggat caccccaaat 3250861 gaatcgaatg tgatctgcat cacctttttt cgtccgaatc ttgatatgca cagtccgccc 3250921 atcataagaa taagcatctg tgctgaatgg ctggtgatga atcgctgcat attccatcat 3250981 gtttccccct ttgatttccg ttttattgaa gccggctcat agtttgaaag tatcatgatg 3251041 aaattgtggg aacaatcctt ttcaccctgt taccgataac agaataaggc gcttacagcg 3251101 ttgattctcg tacaattaac tctggttcaa aaaatagact tccttgtgca gcgccgtctt 3251161 cattcatttt tttcagcaac attttcgcac aggcttcccc catttcaaca acaggctgtc 3251221 tgaccgtagt caagcgcggc gaggagatgc gatcaagaaa cacaccgtca ttcccggtaa 3251281 ccgcaacgtc ttctggaatt cgctttccaa gggattgcgc cgcacgaatg acgccgagcg 3251341 cgattcgatc agatgcgcag acaaatgcgg cctgattgtc catggatttc agcagttctc 3251401 ttgcaaggca ttcacttttc ttagaactgt tgtcgatccg aaacatattc gattttttaa 3251461 agcttttatt catcgcccgt atatacccct gttctcttgc acgttcgaaa ggctcatcta 3251521 aatcaatgcc aaaaaagaca acttcccgct cccccagccc cataacatgg cgggttgcca 3251581 taaaagtgcc tttctcgtta ttcacatcga taaagtcata gcccatttca ttttgtccaa 3251641 atacgacgag cggcttctca aaagctttta ttacaccttc aaaatcgttc tttctcaagc 3251701 cggtggcaat aatgccgtca cattggccaa tattaagaga atttcttgtc acaagctgga 3251761 gagcatagtg attgcgatcc agctccctgc tgattcctgt cagcaggttc atgtaatatg 3251821 gttctgtcgt atccatttcc tcaagtatca atagtttcac aacctgtgtt ctgttttgca 3251881 cgagcgctct cgccgcataa ttagggatgt aattcagctc tttcatcgca gaatgaacaa 3251941 gctttttcaa ttcatccgtc accgtctcag ggtgattgat cactcgtgat accgtcattt 3252001 tcgaaacatt tgcttttttc gccacatctg acaatgttgc cattttcatc ccctccttat 3252061 ctgtgcttat tatccaaact agtgataaag tcctctatta ctgctaaata tacgatgcag 3252121 gccaaagaga aataaaaaag agatttccct taaggaaacc tcactttgtt aaaaacactc 3252181 gatttttcat ggattcatac gctaggtggc agactcattc tctccacttc catcagaaaa 3252241 tctctttttt aaatttctgt ccactttttt tctaaaatcg gataagaata attttgcatt 3252301 tgctcaatta actcatccgg ccgtgacgag ctgtgaatca gttttaggtg cgattcgtta 3252361 gaaaaccctt cttgaatgct gtatttcacc attttcatca ttggttcaaa atatccgttt 3252421 acattgtaca gtccaattgg cttttggtgg atgccgatct gtgcccagca cagcacttca 3252481 aataattctt catatgtacc gaagccgccc ggcatcgaga taaagccgtc cgccagctcg 3252541 ctcattttag cctttcgttc atgcatcccg tttacttcaa tcagctcagt cagattctga 3252601 tggacaacct ccccgctgaa caaaccgctc ggcatgaccc cgattgcagt tccgccgttt 3252661 tccataatcg cgtcagcaat cgtgcccatc aagcctacgc gggagccccc atagacaagg 3252721 ccgattccct gctcagccat atacacgcca agctctgccg cttttctttt atacgcttca 3252781 tttcccccag ggtttgatcc cgcaaataca caaatggttt tcatcttgtc atctccgcat 3252841 ctatatatcg tgttaaacat tcaaaaacac actatatatt gtcccatctt catgtgataa 3252901 tatcaatatg aaatacataa agaatgcagg agtgatgagg ttgcagctgg ctgatgcaga 3252961 aaaatggatg aaagagtttt acgaaaaaag aggctggaca gaatacggac cttttattcg 3253021 cgtcggcttt ttaatggagg aagccggaga actggcccgg gctgtcaggg cgtatgaaat 3253081 cggcagagac cggccggatg agaaagaatc gtcacgcgct gagcaaaaac aagaattgat 3253141 tgaagaaatg ggagatgtca tcggaaatat cgccattctt gctgatatgt atggtgtctc 3253201 tttagaagac gtcatgaagg cccaccaaga aaaactgaca aaacgatttg agcatgcata 3253261 aaaaagcggc cgcgatggcc gcttttttta acctgtgatt tcatcatggt gatcaaagaa 3253321 atgctgcttt cctattttgt gaaaaaggcc tgttttatgc agtagctcct tcggctgcga 3253381 ttgcaatcct acaatcatca gctttccatt gtggcgttta attcgattca taatgttccc 3253441 aagcaccgct tcagctgacg tatccatata gtgcacctta ttcatgagca gaataagggt 3253501 tttcggtttt ttctgtacat gctccagcaa tgacgattca agggaatcaa ttgatccgaa 3253561 aaacagcggc ccttctatgg catacatgct gacagatgga tcttctctct tcgccagaac 3253621 aggatgcgtt tcctgattgt ggatgcgggt cgcttcgctc attcttctga taaagaacac 3253681 gaatgcaagc agcaatccgg ttgccacacc gatgattaag tcaaacagaa ccgtaagggc 3253741 gaaggtcgcc gccaaaataa aggaatcagc atttttcagt ctcagcatgt ttgcgacttc 3253801 cttgcgctca ctcatattcc atgcgaccac catgagaatc ggtgccatac tggcgagcgg 3253861 cacatgggac gcataaggcg caaatacaag caggacaagg agaacgacta cgccgtgaac 3253921 gacgccggaa actggggaaa ccgctccgtt ttttatattg gtcgccgttc tcgcaatcgc 3253981 tcctgtagcc gggattccgc caaacagggg cgctgccata ttcgcaatcc cctggccgac 3254041 aagctccttg ttgctgtcat gctttgagcc cttcatgtta tcagcgacca ttgcggacaa 3254101 aatcgactca agtcctccaa gaagcgcgat gacaagcgca gccggaaaca gcataaccat 3254161 tttatccaaa gtaagctcag gaaactgaaa ttccggcaaa tggcggggga tttctccata 3254221 agttgacccg atcgttgcca tgcggtcagg gaaaaagaca accgcgacca ctgtggaaat 3254281 aagaagcgcc aacaaagcgc ccggcacttt aggcatcacc ttggcggata caagcaaaat 3254341 gacgagcccg atcacagctg tcaaaatggc atacacgtta aaggtgccga gctgctgcac 3254401 aatttcaaac atgttgtgat gaaagttctc atgtttttca acatttctca atccgagaaa 3254461 attagcgatt tgttccgtaa agatcagcac ggcaattccg gctgtaaaac cgacgataac 3254521 gggtttgggc acgaatttca ttatttttcc gagcttaaac agcccaaaca gtaccagcat 3254581 cactcctgcc ataaaccccg caatcagcag attttccaag ccgtactgca tgataatgcc 3254641 gaataaaatc gggacaaagg cgcccgtcgg accgccaatc tgatattttg atcctccaaa 3254701 caaagaaata caaatccctg ctataacaac agtgtatagc ccatattcag gctcgactcc 3254761 cgaggcaatg gcaaacgcca ttcctaaagg aattgccacg acacctacta cgatacctgc 3254821 aatcaagtct ttctgaaatt tctgcaaatt gtatcccttg aatctccctg agaatcgcat 3254881 attttgttat aacctccctt atgagtgatt gtttataagc tcagtttcat aaccgttaat 3254941 gaccacatca agttttcctg tttcagggtg aatgacaagc ccgtgaaccg gcactttttt 3255001 cggaagcagc ggatggttct taatcatgtt cacactgtgg gaaacgcttt cttccacgct 3255061 gtgaaaacca gtcagccacg ttttcaaatc gagtccggca ctcgtcagca aattcaggca 3255121 gctatcctcc accccgcgtt cctttgcttt ctcaagaatc gaggacgcat tcagccctga 3255181 cattccgcat tcatgatggc cgacaatgca tacctcttca gcctgcaatt cataaatcgc 3255241 gaccagtatg cttcgcatca cgcttccaaa tgggtgagaa acgatggctc ccgcgttttt 3255301 tacaatttta gcatcaccgt ttttaagccc cattgcttgc ggaagaagtt ctgtaagcct 3255361 tgtatccata caggtgacaa tgacgagctt tttcgaagga aactttgtcg ttttgtacgg 3255421 ttcatacttc ttctcactga caaaccgctg attgtgttcc aaaattgatg ttaaagaaac 3255481 catttgattc atctcccatc catatgattt tgcaagcctt cttacccagc ttacagtaag 3255541 gaattatagc ataggaataa gccaagaaaa ggttttcaaa aaaagacact ataattggac 3255601 tgtagaatca aaacataaac atttatatct ttcaaagata ataaaattta tatttaatgc 3255661 atcctataat ccggctgcag ttcgtatatc gatgatttgt ctgacaaaaa atatgggtga 3255721 attctgataa ttaaaaaact tttttaagca gatttagctg ttcgatcttc attttaagtt 3255781 caaaagaacc agaaattaaa aaaacgcagc tatattttta acatctattt attttcgata 3255841 taatgaatta gacaacagcc ataaaggggg agccttgttg aaaccatttg tatttatcac 3255901 aaaaccgatt cctgaagaga ttgaagcatt catcggtgaa cattgccgtt atgaagtatg 3255961 gcaggaggat acgcttccga gtgacgtgct atttgaaaaa ttaaaagaag cggaggggct 3256021 tttaacatca gggacgtccg gaccgtcaat caatcgtgag ttgctggaac acgcgcctaa 3256081 gctcaaagtg gtcagcaacc aatcagtagg ctacgataac ttcgatatag aagcaatgaa 3256141 agaaagagga gtcgtcggga ctcatacacc ttatacactg gatgacacag ttgcagatct 3256201 ggctttttca ctgattctgt cttccgccag acgtgttgcc gaactggacc gttttgtcag 3256261 agcaggaaaa tggggaaccg tggaagagga agcgcttttc ggaattgatg ttcatcatca 3256321 aacgttaggc attatcggca tgggcagaat tggagaacaa gcagcgagac gcgccaaatt 3256381 tggttttgat atggaagtgc tttatcataa ccgacatcgc aaacaagaaa cagaagacag 3256441 catcggcgtt aagtatgcag agcttgatac attgctggag caatctgatt ttattcttct 3256501 cattacgccg ctgactgatg aaacctatca catgatagga gaacgcgaat ttaagttgat 3256561 gaagaattca gcaattttcg tcaatatttc ccggggaaag acagttgatg aaaaagcact 3256621 gattcgcgct cttcaggaag gctggatcag gggagccggc ttagatgtat acgaaaaaga 3256681 gcctgtcacc caagataatc cgctcctgca gctggataat gtcacgctgc ttcctcatat 3256741 cggttcagca acagctaaag tgcgcttcaa catgtgcaaa caggccgccg aaaatatgct 3256801 cgcagcgatc caagggcaaa caccgaaaaa tcttacaaga gaatttcaat aaatcaaaaa 3256861 tccggtctga taacagaccg gatttcatat tacatacgct gaagaacagc acgcttataa 3256921 atatgacggg tgacgatata ataaagagcc tggaatacaa aataaatgaa gatgacaatt 3256981 acggcctcaa gaaataaatt ggaattcagc atattactta acgctgcata cgcaaagccc 3257041 gcgtgaatcg tacctgcgat aaatgggatg aagaataaaa atcctatttg ctttccaagg 3257101 atcgagtgaa tctctttgtc cgtaacccct atcctcttta acgctaacac ctgcactccc 3257161 gtatcttcta tttccgtaaa catccgcaaa tacagcatgc ttccttgcac gataaaaaac 3257221 agcacgctga caaacagacc aataaacagc attaatgcaa ctccctgctt cacaatttga 3257281 taactaggag cacgtgtttg aaaatcagat gtatgttctt tcggcaccat gttttcaagc 3257341 ttttcagaga catccaccgt ctcctgccaa tgctcaagct cataacctac cattctcatc 3257401 tgttccttca gcggcacatc ctgtgacaga ctgtcaaagc tcttttcgct gacaaccaat 3257461 aaacggctga ctccatcgac agacatcaat atccctttgt tttgctgctt tttcatgaca 3257521 taggaaaggg tttttcctga cttcatatga aatgctgctg tttccccttc tccaaatgtg 3257581 tctttcacca tcatttgaaa agaaacatta ataaatgctt cattttcttg taaatgaata 3257641 actgggaacc ctttttcctt tgcgacttga ttatagactt tttctgaaat cagcaaagct 3257701 tcagcttcca tcttcttatt tccatacggc aagtctgact gaaaagtgac aggaatccct 3257761 gtggcatcca ccttatacgt gataacagca tgagcttttt tcaatgtatt ctcagccgtc 3257821 tcaggcttca tgacctgaaa gcgggaagca tccttttcca cccaggaaac agactgagga 3257881 atgctttgct cctcctgcct ttgtaaatcg gaataaaaca tatagatgac acctgtagct 3257941 gttagtatga ccgctgtaat gacagaggtt aaaaacagca tgcgtgcatg atccttcagc 3258001 ctgaatatca tgttggaacg cacaatgata tttgtgcctt tgtagaagct gtgtttcttt 3258061 cggtacagca tgcggaaaaa tgccacactg ctttgggtaa aaaagaaata cgtgccaatt 3258121 aacactaaaa tcaaaattgg aaaaacccga aacatcatgt caattgcatt ggctgttgca 3258181 gatagataat aaccgctgcc aagacatagc aaagacaata cagtgagcca tttcgaataa 3258241 actggcaaac ttttcggctt tttggctgat ttaatcagtt caatgatttc cagcttccga 3258301 atccgtccca gtgataaaat gagcagcgtc tgaaacagga tgagaaagcc ggcaattgtc 3258361 atcacaaacg ctttcggcac aatggcaaac gaaatcggca ccttcacgct gagcatccat 3258421 gtcatgatca taaaaaacag ttttgaaaat aacaggcctg ctccaatgcc ggccgcaatc 3258481 gccgcaagag aaataagtga ctgctcataa taaatcatct tgcgaagctg ctgctttgat 3258541 gtgccaaaca gtgtcagcag cccaaactct ttctttcttg cctgcaaaaa cgctgaattg 3258601 gaatatgtga tgaaaaatat acaaaacaca atgatgacga caagagctgc gctcaagcat 3258661 gttttgacaa ggcttcctcc atatatattg tcttcattga catcaggatg aaaaataaat 3258721 gatgtgaaga caaaaaacac cgaaacggca aacacacagc ttaaaaagta ggccacatac 3258781 cgttgcagat tcccaagaat gtttttacgg gcgatagttc tcaaattcat gaaaatcgcc 3258841 tcccaacaca ctcaaggtat ccaatatact ttgataaaac acctgcctgt ttgttcctct 3258901 gtgaatctct gaaaagaaac gtccgtcttt aataaaaaca atccgtttac agaaacttgc 3258961 tgctgtggca tcatgcgtaa ccaacaaaat cgtcgcttcc ttttcctcat tcagctgagc 3259021 cagtgtgttc atcacttgct ttgccgattt tgagtcgagg tttcctgtcg gttcatcggc 3259081 aagaatgagc gccggattgt gaataatcgc tctggcacaa gctgcccgct gctgctgtcc 3259141 gcccgacacc tcatatgtgc ggtgatcgag aatatgcttt atttgcagcg tatccgccag 3259201 ttcatccaat cgagcttcca tttctctcag ctttacctta tccaatgcga gcggcaagag 3259261 aatattttca cgaatcgtca gcgtatcaag cagattaaaa tcctgaaaga cgaagccgag 3259321 ttctcttctg cgaaacaaag ccagctcttg gtcctttaac gttttcggct gaatgccgtt 3259381 gatcatcatc tcgccctggg tcggcttatc aatggtagcc agcaaattca aaagcgtggt 3259441 ttttccgctt cccgacggcc ccataatccc gacaaattct ccttttgaca cactgagatc 3259501 aaaggcgctg agcgcttggt atgatattgt tcctttattt gaatagtatg ttttcgatag 3259561 gttcgttgtt tgcaacacgt tcatgttctg ctcctccttt ttctttatta taaaaaggaa 3259621 gtcagcatcc tcccatcgaa ctttcttgca attccgctcc ccaatcttac aatgctgtca 3259681 cattcacgag ggtgtcactt gaaaacacga tggtcatcac agtgccagcc ccttcttttg 3259741 attccgcata cagcttatgg ccgagacggc tgcacacctg ttttgctaaa taaaggccca 3259801 ttccagttgc ctctttcatg gttcgtccgt tttctccggt aaaaaacgcg tcaaaaatcc 3259861 gcggcagatc ctgcggcggt atgccgattc cttcgtcggc aaccgacaag cgcgtctcat 3259921 gtccctgtgt ttcaatccgg attgtaatag ggtctcccac accttgcttt gaatatttta 3259981 aggcgttgaa aaggatttgc tcaacaacaa aggaaagcca cttttgatca ctggaaatct 3260041 gaacggcatt tggcggcaca tgtaatgttg gaaaaaggcg ccgcttgata aactgacgtt 3260101 tttcctgatt gatcagtgaa cgaaccattt ctgccaaatc aaaggtttgc ggctttacat 3260161 caaatgcaaa ttcctccagc cgggccgttt gcagcatcat atcaagaccg tggcgaaatc 3260221 tctcattctc atcctccagc tcctctaaaa acgtcggaaa agaggatgag gttccgtttt 3260281 ttccttcctg aatcattaag gatatgacag ataccggtgt tttcatatgg tggacccatt 3260341 ggttggtgaa ggtgtaatgc tgtttttgct gattgatata ttgtgagagc ctgctttcgt 3260401 attgctgccc gagtgcgttg atcatcttcg tccaaagcgc ttgctctcct gttcttggct 3260461 ttctggcttt caaagactgt ccgatgtcat tcgaagaaga ggcttgttct gcaagctttt 3260521 taacatatgt gagaaaggaa aattgccgaa cataatcagc agcaaaacct gcggctaaaa 3260581 gagtaccggg caaaatccat atgtacatca tattttcttt ggaaggttct gcgccgctct 3260641 ctacaatgct taaatacgca atcagcatgg cggaccctat ccctaataat gaaaatagaa 3260701 taatggctaa gcggtcgatg agataagtct ttaacattcc gcttcatcct tccgattgac 3260761 ttgaaattga taaccttgtc ctctgattgt ggaaatgcaa tctgtcagtc ctgcattctc 3260821 cagttttctc cgcagccgat tgacattgac cgttaacgta ttgtcatcga caaaatcaac 3260881 gtcatcccat aacgcctcca atagttcatc acgagagaca atttttttat gctccctcac 3260941 aaaaatcgag agaagctgga attctttttg ggaaaacaaa atccggacgc tgttccattc 3261001 ggcctcattc tgatcaggat aaatcgtcag cccgccaagc tccactattc tagattcctg 3261061 cggcaaagag ggcgaatatt caccatatgt gcggcgcagg acgcttttga ttttggccat 3261121 cactacctct agatggaacg gctttgtgat ataatcatcg ccgccatttt caatcgccat 3261181 tacctgattc agctcatcgg tccgtgccga tataaagata atcggcgcat tggaaatggt 3261241 acggatttgc ctgcaccaat aaaacccgtc aaaaaaaggc aggttgatat caagcagcac 3261301 aagatcaggc ttcatttctg caaattccaa ttttatatca ttcagctgtt cagcaatttt 3261361 cacttcatat ccgtattttt gaagatgacc gcccagcaaa gaagcaatcc gctcatcatc 3261421 ttccacaagc aaaatccgat acacgttgat cccccttata tgtacatcac gatgattttt 3261481 ctagaagatt ccaaaattat tatagcatgt gcggaatagt aaatcggtct ttttcttttt 3261541 gttatgatag aatgataaag gtaaaatttt cataataggc aggtgtcgtg atgaagaaaa 3261601 tcatgctgtt tctggcaatg acgtcaattc tttcagcatg tcagcccaac tataccggga 3261661 aatacataga aattggggat acactaactg actataccaa agagtgcttt aaagagaatg 3261721 aaattcctta taaatacgaa aagggaaaac tgtatatccc agaagacgca tttgatacag 3261781 caatctacac ttgttcataa gaaaaagctt gcagataacc tgcaagcttt tcacgttaca 3261841 aaaaatgagt atttaatttc tcttcaaatc ctgaagggcc gatgtcgctt ttttgaatgt 3261901 taccgccgtt ttcataaatc gtaaaatggc gctctgacat gaccatcctt ccgctcggcg 3261961 tcagctttga ggcaagcagg gatttgttaa aaggagattt ttcatgagag tgaatgatgt 3262021 ccttcatgtt atctaaatca ccgagatcac tctcttcaag ggtaaaggcg tacccaattt 3262081 gccagccttc tcctttgtcc atcagcagaa catagctgcc cttttctgtc tcttcctttt 3262141 tgattcggaa tgacccgact ggtgactgta ccgtttctcc ggaaagcggt atcggctgga 3262201 gcgccaggtt gatgccgaag ccgatatcaa cgaggtaatc gccgttttcc gcagacagcc 3262261 atacagcagc atgcgtccct tctagtgccc atccctcttg atcgcctgca taaaccgttc 3262321 ctcgaatgag cttcacatga aacccggcct cacgcaagac aaaataaagg aaaccattta 3262381 gatcgtagca taggccgccg tgctgatctt tgagcagacg tcgccatagc tcttcttttg 3262441 tgatcttata attctctttt gcaagtacgg cacggttttc gaatggaaaa cggtatgcca 3262501 ttgctttaag aaaaagggga agatcgccga agctgacatg gtctttctcc cagccgattt 3262561 tctgaaagca gtcttttaga aagtcactca tttttatcac ctaaacttct tcttgaacgt 3262621 aagcagccag cttctccagc gcctcttgtt catcttctcc ctgggcaatc aaggtaacct 3262681 cagtgcctgt gcttaccgca aggctcatca gccccatgat gcttttggcg tttacttttt 3262741 tcccatcctt ctcaagaaac acatctgacg taaaccggtt tgcttcttgt acaaacaaag 3262801 cagcaggacg tgcttgcagt cctgtcttta atcgaacttc cactttctgt tgaaccataa 3262861 gatctcccct tttctttacg gttattttaa agtgacggtt tgccctgtcc gcagctgttc 3262921 tgcgatttcg tcaagttttc tcagcctgtg attgatccct gatttgctga ttttcccgct 3262981 tgctaccatt tcccctagct ctttcagcgt cacttcctga taatcaatcc gcagctgcgc 3263041 aatttcccga agtttttcag gcagcgcctc caggccgatt ctttcatcga tgtatttaat 3263101 attttccacc tgtctcagcg atgcgccgat cgttttgttt aagttggctg tttcacaatt 3263161 gacgaggcgg ttgaccgaat ttctcatgtc ccgaacgatt ctgacatcct caaatcgcag 3263221 aagcgaattg tgagcgccaa ttacgttcag aaactctgta atcttttcag cctcttttaa 3263281 ataggtaata tagccttttt tccgttcaag cgttttgctg tttaactgaa actcatttaa 3263341 caggtcacat aatgaatcgt tatgctcctt ataaagagag aagatttcta aatgatacga 3263401 ggaggtttcc gggttattga ccgaacctcc tgccaaaaat gctcctctca tataagaacg 3263461 cttgcagcat ctctttttga ccagctcttt cgaaatactt cgttcaaaca caaaattctc 3263521 cccgagtatt tttaaatcct ctaagatcgc ttttgcattt tctgaaaaac gcacaatata 3263581 gacgttattc tttttcagcc gcattttctt tctgaccagc agctcgaccg acacatcata 3263641 ttgttttttc agcaatgtat agatgcggcg ggcaatcgcc gcgttttcgg tttgaacatc 3263701 gagtacgaga tggcggtttg taaatgataa agctccattc atccgaatga gtgcagacag 3263761 ctcggcatta atgcagcagt ccttcacttc cagattcgtt aattcttttt ttgtttctga 3263821 tgcaaatgac atatagccac ctcatttcaa ggcttcattc tttcagtaaa tcaacaagaa 3263881 gagaggccac tttatgtgta tcgtgacgta ttacgtcatt tttatacgtt acaatttgat 3263941 ctctgatgac ttcaagcccc atcgctttca gctcttcgat atcaaaatca acaggacgcg 3264001 ccgattccat ttcgtactta cgttttattt cgtcgggaat gtcttcactg ttcactaata 3264061 tcgtatcaat aaaaccacag cccatatgct gattgagcgc tttcacatga tcagcagcgg 3264121 tgtaatggag cgtttcgccg ggctgagtca tcacgttgca aatgtatact tttttcgccg 3264181 gcgcctttat cacttcttcc ccgatttttg ggacgagcaa attgggaaga atgctggtat 3264241 agaggcttcc cgggccgata ataatcaaat ccgcttccct gattacgtct attgtttccg 3264301 gcagcggatc aatctgttca ggcgtgagaa aaacacgctt aatgcgctgt ccgtattctg 3264361 ggatcgttga ctcgcctgag accacgcggc catcttccat ctcagcatgc aaaacgacac 3264421 tggcattggc agccggcaaa acctttcctc ttacattcag caccttgctc atttctgtga 3264481 cagcgtgaaa aaaatcaccg gttatatttg tcatcgctgc caaaatcaaa ttcccgagag 3264541 aatggcctgt taagtcattc cctttattga agcggtgctg aaaaagatct tcaacaagcg 3264601 gctccacatc ggataaagcg gcaagcacat ttctgatgtc tccgggaggc ggaattttca 3264661 gttcattccg cagacggcca gagctccccc catcatcggc aactgttaca atggccgtga 3264721 tgtcaacggg tttatgcttt aggccccgaa gcaatacaga aagacctgta ccgccgccaa 3264781 agattgcgat tttcggcttt tgtcccatct tatttccggc ttctcttttc aatgtcccgg 3264841 tgagtaacat gagtatagta atcctttttg aaataatcag ctaaattctc ggctaatgtc 3264901 acagagcggt gctggccccc tgtgcagccg atcgcaatga caacctggct ttttccttct 3264961 cttttgtaag atggaagcat aaagctcagc agatcaatta atttctcatt gaacttttgc 3265021 gtttcattcc acttcatgac gtaagaggaa acctctttat ccttgccagt cagcggccgc 3265081 atgctttcga tatagtacgg attcggcaaa aatctgacat caaagacgag atctgcatca 3265141 attggaatac cgtatttaaa accaaatgac atcacattta cggtaaatgt ctctccttgg 3265201 tttgtcgcaa agtgcttcac gattttttca cgcaaatcac gcggcttcat gtcagacgta 3265261 tcgtaaatga tttgagagcg gccttttaat tcctcaagca gctctcgttc tagcgcgatg 3265321 ccttcaagcg gcaggccagt cgctgccagc ggatgcgagc gtctcgtttc tttatatctt 3265381 gtgacgagaa tggaatcctt cgcgtccagg aataaaattc gcggtgtgat ccacggattt 3265441 tcggccattt catccagcgc ttcaatcagc cggtcaaaaa attcgcggcc gcgcaaatcc 3265501 atcacgagcg caactttgct cattttcgaa tttgattcct tcatcagctc taaaaacttc 3265561 ggaagcaatg aaggcggaag attatcgacg cagaaatagc cgagatcttc aaagctttgg 3265621 atcgcgacag ttttccccgc tcccgacatt ccagttataa tgacaagctg aatatcatgt 3265681 gattcactaa cactcatctt tctcccccct gacttgtctt tctatttgat gtgctgcggg 3265741 tctaaacgat aactgagcag ctcaaattcc ggtgtatacg taaatgtgcc gtgcagcagc 3265801 ccttgtccct tcatcataaa atcaaggata tggccgtctc caggggccat aggcaggttc 3265861 tgaatgtcat tgacatcgtg ccactgcagt ttgccttcct ctgattctga tacattttgt 3265921 cctgtatatg aatcagcgac aaacgtaaac atcatccact cggagacaat gtggtcaccg 3265981 tctttaataa taaaggtaaa aacgcctttt aattgaggat ttatgatata gataccagtc 3266041 tcttctctgt actctctgat gacggagtct ctgactgatt ctccgctctc catcttgcct 3266101 cccggcgcga cccaccatcc gcgtctcggc ttttgaagca gaagaacttt gtcatccgtc 3266161 tgaagcacac aatttgtcac tctttgcaag tacgtcacct aaccttcgtc ctgtcatcgt 3266221 ctctttatta taccgcttca agatgcctcc cacaatgaag agacattgac aatcttttct 3266281 tctattttac agcatattca ttccttaatt cagatgattt tgctgtaact ggaattctct 3266341 tttatttatg gacaaaaaaa ggacacggat aactggagaa tccgtgccaa aaaagtgtat 3266401 tcattataaa aagggggtca attactttat taatcataac cgaaaagcat tacacatgtg 3266461 ttacagcgga attaaaaccc agtaacgtaa tgtgaaactc gtatgacagc cctttttatt 3266521 ttaaggtttt cagcgtttct tggagctctt cgacataatg ttgtacgctt tgtgccgcaa 3266581 tgcttccgtc tcctgtagcc gttacgattt ggcgcagtga tttttcgcgg atgtctccgg 3266641 cagcgaaaat cccttcaacc ttagtttcca tgcggtcgtt tgtttcgata tagccttctt 3266701 cattcgtaat gcccaggttt tcaaacggtt tagacagagg aagcatgccg atgtaaatga 3266761 atacgccgtc tgttttgaat tcactttctt caccggttac cgtatcgaca agcgttacgt 3266821 taccgacttt gccgttttcc tcatgaattt ccttcacagt tttgttccat aggaagtcaa 3266881 ctttttcatt atcaaatgct ctcgcttgaa gaatactttg agcacggagt ttatcacgtc 3266941 tgtgaacaat cgttactttt gaagcgaaac gagtcagata tacgccttct tcaaccgcgg 3267001 aatctccgcc gccaacaacg acaagttctt tgcctttaaa gaaagcgccg tcacatactg 3267061 cacaataaga tacaccgcgt ccgcccaatt ctttttcgcc aggcacgccg atttttttat 3267121 attccgcacc tgcagcaatg atgacagcac gggctttata ttcctttgaa ccagctttga 3267181 ctactttgta ctctttgccg tcaatgacct ctttaatatc gccataagcg tattcagcgc 3267241 cgaatttttt cgcgtgttca aacattttgt tagaaagctc aggcccaagg atactttcga 3267301 atccaggata gttttctaca tcttccgtat tggccatttg tccgccagga attcctcttt 3267361 caatcattaa tgtcgataaa ttcgctcttg atgtgtatac agcggccgtc atcccagcag 3267421 ggcccgcgcc gattataatc acgtcataaa ttttttcttc tgacacacta ttcactcctt 3267481 aaaccatctt ttcaagtttg ggctctttct tataagataa gaatccccat caaacgtatt 3267541 ccttacccat atcctataaa atctcatggt gatacgctat ttttttgctc aacacgatta 3267601 aatgtattcg aaaagggtat atgttaataa agaaagagcc ttctgtttat agaaggccct 3267661 tgtcatattt attattgaac aacacgtctt acaacacctt taaatgctgc tttccagtaa 3267721 ggattgctca tagagtcaac agatacgcca tgagatgtat tgtcgtttag gaaagtaccg 3267781 tttcctaagt agattcctac gtgtccattt gttttgtaag tgtcaaagaa cacaaggtct 3267841 ccgcgtttca tttcagacgc gctgacagct tgtcctctgc caactaacgt atcagttgtt 3267901 gttccgccta caggtccaag gttaacacct gcagaagcgt atgcccagcg tacgaatgat 3267961 gagcagtcaa aaatacggtt gttgatatca gactgagtgc gtccgccgcc aaacttgtac 3268021 ggagattgtc ctacaatgct tgaaccaacg ctgatcgcgc cttcaattcc gccagagttg 3268081 ctgataacag tgccgcctga attgctgttt gagccgctgc tcttcttaga agatgagccg 3268141 tttgacgaac tgtttgatga accgttagaa gaattgtctg aagaattgtc tgaagaatca 3268201 tcagatgagc ttgcttttga tgattcagtt gtcgccgttt gactgtcatc tgtttgtgtt 3268261 tcatcagatg ctttttgtgc ttcttcctgc tttttgatca aagcagccgc tgcttcttgt 3268321 tcttttttga tgcgtgcttg ttcagcttca gtatttgctt tttgatttgc aagttcagac 3268381 gcctctgatt ttaattcaga aatcgcttta gccgttttct tttggcttgc ttttgcttcg 3268441 tcgaaaagct tgtctttttc attaagctgt ttatcaaggt ctttttgcat tgtttctaat 3268501 ttagccaagg cagcttgaac ttctttcagc ttgtcattca aatccgcttc agaatcttcg 3268561 agcttcgctt tatcctgctc ttgctgtttg attaaatctt tgtctgcgtc cacaatagat 3268621 gaaaccgcag tcgcacgaga gataaagtca ccaaagcttg ttgatcctaa aagaacatct 3268681 atgtatcctt gagatccgcc gctttcctgt aaagaacgaa cgcgtttttt caggatttca 3268741 ttgcgttttt cgatgcgtgc ttcagtttct ttaatctctt ttttcagttt tttgatttct 3268801 tcttttgttt tatcgttttc ttctttttta tcttcaatct tgttgcttgt atcaagcgcc 3268861 ttatcgttaa tgtctttcag ttctttttca atctttgatt gattttcctg aagctcggtt 3268921 aattcttttt ccttcgcttc aatgctggaa gcaacctcag attgcttgct ttcgattttt 3268981 tgtttctttt catctaatgt ttccgccgat gcagttttac ttgtaaatgg gatcaaaaaa 3269041 ctgcttgtcc cgatgacgga agccaaacca agtgtaatta aactctttct cactttttat 3269101 atcctccctt ttactgtgaa cctgtcctca tttggaatcg tattttgaac atcaagtttc 3269161 gttcctcata ctctacgagg aatgatggtt gtttatggtt aattattctg tgcatctctt 3269221 attctggttg tatagcgttt atttcacatc atatgtaaaa aacactaatt ccttatgtac 3269281 gagaatcatt ataccatcaa gtttcgacaa attagcgata aattttatta catttatgtt 3269341 tcaaacagat gtcaagtcac acatcatttg tcatttttct taagcgtgta aaaaaactgt 3269401 cgatattatt ttcttaatat aatctatcta acaaaaaaag agtcgattaa ataaatcaac 3269461 tctttaaaat ttactattct agaatatcat caatatattt catatatttc gtcaaagttg 3269521 ccggagagat gccgaatcgg gccgctgtgt cttttttcgt gtcttgcttg ccatgggctt 3269581 ctttccaaat ataacagatg gctgctgccc agcctttctc attcttcaac ggagcagctg 3269641 cacgaatttg ctggatgaca tgaaaaaccc agcagctcat gacttctgtt ttcatctctt 3269701 ctttttcagc ttgctctaat agtttgaccg tttgataagc gaaaagtgca tcctctgaaa 3269761 cgtcagcagc cgcagaatct ccattcagaa gcagctttac aaaatgagtt tcaaaaggag 3269821 cggtaattct ctttgagcgt atcaccgctt caagatgctc tgtttctccc tttgtgctgc 3269881 tgatataata ggctgcgagt cgctgctcca cagatgaagg aagagcttcc ctccgctcaa 3269941 tccaaggcgc cgggcggtct tcgccgggat attgcgactc gacttttctc cagatcgtct 3270001 cggcaaagtc ggtatgtccc gtaaaataag cagagcagga aagccagtaa aagaaggtgt 3270061 cgtcaccctc aaagccggtt ttatataatg atttgagcca tttatatccg atctcgtagc 3270121 ggccgacaag cgccaaagta gcacccaatt tataacgctg ctccaatagc atcggataga 3270181 cattggagag ctgatcactc aattccgcca ctttttcgtc ttctctttca taatagtaga 3270241 aaacgagaag attgcataag gcgtgaagat ttccttcatt atgagaaagc acttcataag 3270301 cggtttgctt cgcttttaca acgtttcctg aatagaaata ggcaagcgcg agattgttgt 3270361 atgctgacca aagctccgga tattcagttg tgatttcctc aagcgccgca accgcttcag 3270421 caagctggcc gctttccagc aatgactttg cccgatcctg tttcaccagc agttcatcct 3270481 gatcatacaa cgaatcctca atgccgtcgt ctcctaaatc gagcaaatca agcagactat 3270541 cgttttcttc ggcgaattca ccatccgggt ccgcatcaga ataagcggcc gcttctttat 3270601 aagcttcctg gaagagcccc agatgggcaa agttattcgc tttaaagtaa tggcactccg 3270661 gcatttcggc ctccagattt gccatgatat agtcaagaag atcgttcgac tcttgatact 3270721 ggcccatttc cgaataaatg accgcaagct gtgaaagcat ctctgaatcc tccggctcca 3270781 aatgaaccgc gcgctgaatc agtttgcttg cccgttttag attgcgctct ttatacgctt 3270841 tcaagccttt atgaaaaaaa tattgtccat cttgaagcag ctggacaatt tgtgcgtgat 3270901 ttttatgttc agaagtgtgt tttcccacaa ctaccctccg ttttatacaa tattaccgtc 3270961 agtagtatac cataaatcgt aagcccctca atagttcaaa aggaaggatt gggaaaatcc 3271021 ctcctctttt ttattggctg attcgaccaa aatttacccg gctttgtttt ctaagtccgc 3271081 attcattttc agctgctgtt cagcaaaatc ccggtaaagg ccatgggaag ccattaactc 3271141 atggtgtgtt ccacgaccgg taatttcccc tttttcaaca aacaaaagct ggtccgcatc 3271201 tacaacggta gataggcggt gagcgataac aatcgttgtg cggccctcca tcagcacctc 3271261 cagcgcctgc tgaactgatt tttcagattg gctgtcgaga cttgaggtag cttcatcgag 3271321 cataagaatg cttgggttac ggagaagcgc tctcgcaatc gcgattcttt gcctttgtcc 3271381 gcctgacagc ataatgccgc gttcgcccac ttctgtatca aactgattcg gcagctcctt 3271441 tataaaattg agcgcatatg ccatctccgc ggctttttcg atctcagcat ccgtcacatc 3271501 tcgttctaac ccgtagcaaa tattttctct gattgtcccg gacattaacg ggctttcctg 3271561 tgatacatac ccgatatgct ccctccacga ttcaagcgag taagtatcga ccggctcgtc 3271621 ccccagccga atggtccctg cagtcggaga ataaaagcgt tcaagcagct taaacagcgt 3271681 cgtttttccc ccgccgctcg gaccgacgat cgctgtcact ttccctgctt caatgacggc 3271741 gctgacctct tttaagatca gctgatcagg cttatatcca aaagacacgc gatcaagctg 3271801 gataggcaga tgtgcatttt caatttgttt tcctgtcact gtatcttcct cttcctctgc 3271861 caaaatctca atcattcgtt ctgttgcacc gattgatttt tgcagctgtg tgaaaaacgt 3271921 tgtaatctgg cccatcggca taataatttg aaacaaatat aaaataaaag ccacgagcgc 3271981 tccggctgtg agctcgcctg atgagacctg catgccgcca tatccgatca ctgcgacaag 3272041 cgctgccatt aacacgagtg aaataagcgg gccgacaagc gattgaacct tggcttcacg 3272101 aacgccaagc ttaaataatg aggaaatccc catcttcccg cgcccatatt cgacatcctc 3272161 cgcatttgaa gccttaacaa gtctgatttc cgggagaatt tgattaagca ggcctgtaaa 3272221 acgagccgtt tcatcttgcg tttcccgtga aatggagaac attttccgtc caatcggcac 3272281 caaaataaga gcggccagcg gaacgaccac taacacaagc agtgtcagct tccagttcat 3272341 aataaacaag attgtcaatg atccaatgac agaaatgatg cctgtaataa atccgctgat 3272401 atgggttgta atcaattctt tgaccaccat cgtatcgttc gttacacggc tgactgtttc 3272461 tccggaagca tttgtatcga aataagagac aggcagctta attaatttct tccataataa 3272521 ctcccgcagc ccggaaatga ttttttgtcc attatagtta agcgcatagg tggcataagc 3272581 gcttaaaccc gcctgaacga aaaacaccag cgcgatcaaa ccgatttgcg tgcctgacag 3272641 atttgacata gaaaaaccat cgacaagctg cttcgttaat aatggaatga gcaggctgac 3272701 cagcgtggtt actacactga gggcaagcgc aaaggcgagc tttccataag aaggattggt 3272761 ccgtcttact aaggcaaaaa agggtttcaa tttactttta gatttttgtt tcttggttgg 3272821 catatatttt cctcctgttt cagcgttcag aaaggtgaaa agtcatagca aaaggatgat 3272881 ttttactctt tctcaatcat atcaatggag aaagactttt tcagtatatt tttgccgtga 3272941 tcaaaataaa aatctcccac tcattgtttg aataggagat ttttgtgtta gacatctttc 3273001 actggcttct tttttctgta agtcaatgtt acatcctgct gtcgcaggtc ttctattatc 3273061 attttgtacc gatcaacttt tgcggtatgt tcttctttta tcatctgaag ggcagctttt 3273121 cgtttttcgc tattagactc aagctctttt tttatttttt ttacaatcaa ccctttttgc 3273181 cctttgattt cctcttttaa tgaagactca aatttctttg tcaggctgag aaagtcgttg 3273241 atcggttgat tgagggtgcc cgctttcccc ttcatttcat cttgggtaag aaacatatag 3273301 gtcgttgata caatttctgt ttcactttct gaaaataagg aagtcactct tcatattcct 3273361 cctaagactg aaaatcaaat aactgagaaa tcatttcttc tttttcaaac agcttttcaa 3273421 tactctcgcg gatatttttg ataaaatctc ttttttctgt tgtctgtttt tttaattcag 3273481 caacaattcc atcatttgca ggaagcgcac ctgtgtggaa tgattcatga actgagattt 3273541 tctccaattt atcgaatgtg tggctgaaac cagctgcaag ccggaattga agatcgaagg 3273601 cataatgcga agggttttct tccatatgat gaatagccgt gatgatcgcc tgctttttgt 3273661 ctatgaagtc ttcatcgatt tcctgactgt aaaccttctg gtacttagaa atcgcatctt 3273721 ccatatcttc aacgattttc ataccgtttt gatagattct gacagcggat gagagattga 3273781 cttgaatcgt ttctcccgag ccactcttcc ctgtaaaata aatatcggag cctttatagc 3273841 tgaagccttt ttcctttgac aaggcgttga gcatttgaac gatgctgtgg ccgtcgacga 3273901 taagttttag tgcgtctttt gtttctgtgt cgagtgtttt caatgaggac agaattgatt 3273961 ttacatagtc cactatttca ccaacgtctt ttaaagcttg cataaattgg ccatgtttta 3274021 gatggtctat gaaatgttcg taccgtgact ctatgcctcg catactcgca ttaatattcg 3274081 ttaattcttt tttgatgact ttcttttgcg tttcatcaat ataaccattt tcagctaact 3274141 gatctacgac cggtccgctg tttctcaaca aggtatgaag aaaacctaaa aacgacggca 3274201 gttcctcttt tattcggcca tacatttgct taacatcatc aaaatgctca tataggacac 3274261 ttactttctt taaagcgccg tctgtgtttt tcactttttc aatcaggtct atgtctatcc 3274321 cgctggctgc ctttataaaa ccgttcaagc cgtctttttc atagtcatcc ttatattttt 3274381 gaaggaattt ttgaattgac ctcacatctt cgtcaggaac cccatccata atgtttcgga 3274441 tgccttttac acttgtattt gtatctgcca tcttcacatc accgaatgta ataaaatcgg 3274501 ccttgccgct gactccatac agcgggtcat cttttgagat gcgctgagtg atgtttgttg 3274561 ttacgccttt gtcttcataa tatttttgga tttctttttt taacttttct ggcgggatgg 3274621 aatctatatc ttcatattta taactaaatt tcctaataac atatctatat aaactttcat 3274681 cagtttcaag taattgatca atattgactt gagctccatt taccccataa acttcatcat 3274741 attctccatc aatcaattgc accataactt ggttattatt tgcaagtgaa tgtcctaagg 3274801 cgaatgtttt taaatcctca gagttacctg ctgctttctt tgctttgtta gtaaactcct 3274861 ttgtagcctc atactgacta tgatcaattc ctaaaaaaag accaaaaaag ttatatgacc 3274921 aatccttatt atcggcacta ccttctgaaa taatctgaag ctgatcaata tgttttttct 3274981 catctattat atggattgcc gttccatcgt aacctgattc tctggtcgaa ctttgtatac 3275041 ttgtattctg atttacaagt tcattggagg tgtaaatttc aattttcata ttctcaggaa 3275101 gatcgtggtg ggtttcctct ttataaattc tgcgtatatc tgcttcgaaa tccttcttag 3275161 ctttcttaac ttcactcgca atagttgagg caaacttttg tttatagtca tattctaaat 3275221 caattaacct taactttacg ttctcattct caaatacatt tttatttccc atcttatttc 3275281 tcctttttat ctattaaaaa ggtgatagaa ttaattaatt tctcaacttt atttttagcc 3275341 ttttcttcat ctaaggagca tggttgattt tcatttttgc atccaagggt aaaggcgtat 3275401 tctactccta ggttatcttc ctctgtagac ttaacatatc caaaataact gtatgaataa 3275461 ttatattttc tatcaatatc gtcaaagatg tcttttttct tggcagtgta aatatccgtt 3275521 ttctttttgc tgcttttttt gtattcgcct ttataatcat tttttccact aacaatatct 3275581 agcattgtct taggttcatt cgcaaaactt tcttctttgt aatatgttac atggccatca 3275641 aacattacat tggtgtcttt atcataacta ttaaatccaa tactttcttt gtttttcccg 3275701 gttaacgatg atcttcttga tagatacttt ccatcctccg gaaacaacat cctaaaccct 3275761 ttcagcttag attccagcaa ataatatcct ggttcctctt cttttgttga caccatgtac 3275821 tctctcgttt tctcgtcctg aaacgcaggt acttgaggca gatccttggg atccatgtct 3275881 tttggtttta ccgcttctgt tttattgtca tttgtgctgt ttttatcatt gtcattcata 3275941 ctgcatcctc ctgtcagggc aagtaataag ctgaagcaaa taaagatgat ctttttcatt 3276001 acgaacctcc acgggttttg tgagaatagt attctatttt tatatcaaaa ataattctat 3276061 tgacctggtt aagagatgat tatttcatcc tttttcatgt tacatcatgg cggaatttgg 3276121 ataaatagga aatgagactc ggttttgatc tccttttatt aactaatcat atataacacc 3276181 caatataaat ctaaatacct attacttttt tcacaaaaca aaaagagccg tatcatccgg 3276241 ctctttactc ttcaatctca gaatggcgtt ttttcaatac gtcaagcaca tcatccagcg 3276301 gcagggattg ttctctgagc aggacaagca ggtgatacag caggtctgcc gcttcccatt 3276361 tgagttcctc atgatcccgg tttttcgcgg cgatgatgac ttcggatgct tcttctccga 3276421 cttttttcaa aatcttatcg acgccttcac ggaagaggta cgtggtgtaa gctccttcag 3276481 gcatttccgc ttggcgttcc gcgatcaccc gctccagttc gttcatgatg ccgaatcggt 3276541 ccgcggcctg ttcttctgtt tgttcctttg taaaacagct gtagctgcca gtgtggcatg 3276601 ccgggcctga cggttctacg agtacgagca gcgcgtcttg atcgcagtca taccggatac 3276661 ctttgacggc ttgcgtgttc cctgaggttt ctcctttatg ccataacgct tggcgtgagc 3276721 ggctgtaaaa ccatgtttcc ttcgtttcca gcgttttttc gtacgattcc ttgttcatat 3276781 acgcaagtgt cagcacttct ttgcttgccg catcctgcac gatagcagga attaatccgt 3276841 cctcgttaaa acgcagttca tctgcctgtt tcatctcaca ttcaccccgt actctttcaa 3276901 gtatgatttc acttctttaa tcgatgtttc tttataatga aaaattgagg cggccagcgc 3276961 ggcgtcggct tctccttttg taaaagcctc aagcatatgc tgtgcgtttc ccgcgcctcc 3277021 cgaagcgata acagggacgg ggacagcttc ggaaacaagc tttgtcagcg tgtggtcgaa 3277081 accttttttc tcaccgtcgg agtccatgct tgtcagcaat atttctcctg ccccgcgttt 3277141 gacgccttct tttgcccacg cggtgacctc ccaatctgtt ttctttctgc cgccgtgcgt 3277201 gtagacctta tatgtgtcag attctttgtc atacttggca tcaatggcaa gtacgatgca 3277261 ttgagaaccg aaaaactcgg ctccttctgt aatcagctca gggcggagaa cagctgccgt 3277321 gttcaccgac actttgtccg ctccggcacg cagtatcgtt ttcatatcgc tgagctgatt 3277381 gatgccgccg ccgactgtaa acggaatggc aagcttcgcg gcaacctgct ccacaacgtc 3277441 aaccatcgtc tttcgtcctt cgtgcgaggc ggagatatca agaaaaacaa gttcatccgc 3277501 accttcccgg tcgtacactt cggcgagttc aactgggtca ccggcatcct tcaattcgag 3277561 aaattgaatt cctttgacaa cgcgtccttc tttgacatca aggcatggga taatccgttt 3277621 tgtgatcatt tgcgcttcac cctttcaagc gcctcactca gcgtaaactg attggtatac 3277681 agcgcttttc cgatgatcgc tccagagacg ccgtccgcct cattgcgggc gagagcttcg 3277741 agatccgcga cggagctgac tccgccggaa gcgatcaccg atttccccgt ttccttagca 3277801 agctcgaccg tgcttttaac attggggcct gacagcattc catctgtcgc gatgtcagta 3277861 aaaataaaga cttccgcacc ttcattggct agctctttgc ccagttcagt tgccttaagg 3277921 gttgatgttt caagccatcc ctctgttgaa acaaaaccgt ttctcgcatc cagtccgatt 3277981 gcaattttct cgccatattg tttcagcatt tttttgacaa acggagggtt agaaactgct 3278041 gagcttccca ggatcacccg ctcgactcct gctgataaat attcatagac gtcattttca 3278101 gaacggatcc caccgccgat ttcgactttc aggttcagct tttgcgcaat ctcaatcaca 3278161 tggcggtcat tcactctttt cccttctttg gccccgtcga gatcaacgag atggatccat 3278221 tcggcaccct ctttctcaaa taactcagcc atgtcgtacg gtgaatcgcc atatatcgtt 3278281 tccttattat aatccccttg aacaaggcga acacatttgc cgtttctcat atcaattgcc 3278341 ggatataatg taaaagcact cattttttca ccttctgttc tgctgccatt ttcgtaaatt 3278401 gggttaaaat agacattccg accgtgctgc ttttttccgg atgaaattgg gcgccgaaga 3278461 cgtttctttt tccgactaca gcaggcactc gtacaccata atcggcgctt gccagaagcg 3278521 cgttctcctc catcccgtca atgtaatagg aatgaacgaa gtaagcgtag ccttgttctg 3278581 ttttagtcag cagcggagat tcattatgaa aagaaagacg attccagccc atatgcggaa 3278641 ccttcagctt gtttcctttt tcatcttctg ctttcagcct gactgctttt ccttttaaca 3278701 gcccgagtcc tgaagcggtg ccgttttctt cgctttcttc aaataaaagc tgcatgccga 3278761 ggcagatccc gagaagcagc cttccctctg agaccatatc gtgaatcaat tgatcaagct 3278821 tcgtgtagcc caaattgtcc atcgcgtctc caaatgaacc gactcccggc aaaatgaaag 3278881 catcagcttc tttcagctcc tccggctttt cagaaacaaa atacggcacg ccgacacgtt 3278941 caagcgcctt tgagacactg tataaattcc ccattccgta atctatcacg ccgatcattt 3279001 acagcatccc tttcgttgac ggtattcctt taactcgcgg atcgatcgtt gtcgcttcat 3279061 caagcgcacg tcccagtgct ttaaaaacgg cttcaatcat gtggtgggta tttgttccat 3279121 aatgaacgat gacgtgcagg ttcattcgag cttcgagcgc cagcttccac aaaaattcat 3279181 gtacaagctc cgtatcgaaa gttccgactt tagcagccgg gaaatcagcg cgcatttcta 3279241 agtgcggccg gttgcttaaa tcaatcacaa cttgagcaag tgcctcatcc atcggcacaa 3279301 acgccgatcc gtagcgtttg attccttttt tatcgcccaa cgcttcgagc agcgcctgcc 3279361 ctaagcagat gccgatatct tcagtcgtgt ggtgatcatc tatatcaaca tcgccttttg 3279421 cgttaatgga aagatcaaat tggccgtgtt tcgtgaataa atccaacata tgtgtcataa 3279481 acggcacatc tgttttaata tccgcttgtc ctccgccgtc tattgtaaat gccagctcaa 3279541 tatctgtttc gtttgttttc ctgacgcgtt ccgcttttct catttagaaa tcctccgttc 3279601 tctcgcttca attgatctgg catgggcttc taacccttcc agtctggcaa aagccgcgat 3279661 gctttcggca tgttcttcaa aggctgattg actgtaagaa ataatgctcg atttcttttg 3279721 aaaatcagtt acgtttaatg gacttgaaaa tctggctgtt ccgtttgtcg gaagcacatg 3279781 gttcggtccg gcaaaataat caccgacagg ctcagggctg tatctgccta agaaaattgc 3279841 acccgcatgt ttgatactgc caagcaaagc ttccggagac tgtgttatga tttctaaatg 3279901 ctctggcgcg agtgtattga cagtctcaat cgcttctacc attgtttccg ccacatatat 3279961 acaaccgtaa tctctcactg aagcttccgc tatttctctt cgcggcaagg tttccagctg 3280021 cttattcacc tcggctgaaa ccgtctcggc cagcgccatg gaatctgtga caaacacaca 3280081 tgagctaagc ttatcgtgtt ccgcctgtga cagcagatcg gctgcaattt cgctcggaat 3280141 cgctgtttca tcagccagca cgacgatttc actcggtccg gcaatcatat cgatatcgac 3280201 atcgccgaac acttctcgtt tggcaagcgc gacataaatg ttgcccggac ccgtgatttt 3280261 atccaccggc tcaatggttt ctgttccgta tgctaacgcc gcaatcgcct gagcgccgcc 3280321 cattttgtaa atgtctttta tgcccagctc ggctgcagca accaaaactc caggagacag 3280381 cagaccgtct tttcccggag gcgtgacgag aacgattctt tcaacgcccg ctacgagcgc 3280441 cggaatcaca ttcatcaaaa cagatgaagg atatgcggcc gttccccccg gcacatatac 3280501 accggcggaa tccagcgccg tcactttctg ccccagcatt gtgccgtcct ttctgtgata 3280561 aaaccaggag gattgcagct gtctttcgtg atattcccta atattttcga ttgcctgcct 3280621 aatcacctga agaagacgtg aatccagtga ggtgtatgcc tcctcaaatt cttcttttgt 3280681 gaccagcggg ctgtctattt cgatgcagtc aaatttcgcc gtgtagctgc gaaccgcctg 3280741 atcaccgttt gctttaacat cttcaataat ggaccggacc gtctttcttt gctcttccgt 3280801 tccggcatcg atggaacgct tgagagaaag ccgttccgct ccgctgatgg ttttgatctt 3280861 cattttgccg tctctccttc cacaacgaga gataggcggg atgccatttc gtcaatcaca 3280921 tcgtctttca tgcgatagct taccgggttg acaataaagc gagaggtaat gtcacaaatg 3280981 tgctccgttt caacaagccc attttctttc agcgtctgtc ctgtggaaac aatgtccact 3281041 atccgatctg caagcccaat gagcggagcc agttcaattg aaccgttgag cttaataatc 3281101 tcgacttgtt ctccctgctc tctgaaataa ctggaagcca cattcggata ctttgtcgcg 3281161 attcttggcg ctactccgct ccagtctgta ttcggaagtc cggcgacagc taagtggcat 3281221 ttgctgatgt ttaaatccag tacctcatac acatcgcgtt cctcctccag catgacatcc 3281281 ttgcccgcaa ttccgacgtc tgccacgcca tgctccacat acgtggttac gtccatcggc 3281341 ttcgctaata taaaccgaag attttcctcc ggcacatcga tgatcagttt tctcgaatct 3281401 tcaaactcct cagggagcct gtagcctgcc tgcctcagca gccctgccgc ttcttcaaat 3281461 atccggccct ttggcatcgc cattgtgagt aacttaccca ttttgctctt cctttctggc 3281521 accgataaaa taagtgacgt ttgcaaaaga ttttgtcatc tggtcgatat tttctattcc 3281581 cgataaatct tgaagaacca ctttgttccc tttcatgcgt tcttcattcg cataagcgat 3281641 ggcttgcgcc cgctgctctt tgctgaaaat aacagcgtct atttcacaag gttcgtcctt 3281701 catatgaagg gcttcaatca gccggtcgat ccgaagcccg aagcctgttg ccggtgcagg 3281761 tgaatcaaaa tggcccagca gcttgttgta acggccgccg cttccaatga caaaaccgac 3281821 attctcggcg tacacttcaa ataaaatccc tgtgtaatag ctcatgtggc tgaccatatt 3281881 cagatccagg cggacatttt ccgtacatcc gtaatcctca agaatgtccc acagcgcctt 3281941 cagctcatca accacgcttt ttccttgcgc agaatcgacg atttcctcgg cacgtccgca 3282001 tacttctata ccgccccgca gttcaaggag ctcaagcagc ctgcttttat caatggagga 3282061 aagcgggaga gacttgacat gctctctgta gccgacgtag ttcttttcat ataagaacct 3282121 ccgcagcaca tcagctcgtt caacgtttcc gagcacctca acaaacaaag catccgcaat 3282181 gccggcatgg ccaattgcaa ttttaaagga tgccagccca gcgtttttta atgccccgac 3282241 gactaaagca atgacctccg catccgcgct cgtcgtgccg tcaccgatta actccactcc 3282301 gacctgctcg aactcagccg gacgtccgcc ttcacgctcc tgagccctga atacatttgc 3282361 cgcatagccg actcttagcg gatgaccgtg tttcagaagc ttcgatgccg ccacccttgc 3282421 aatcggcccc gtcatatccg ggcgaagcac caatgtcttg ccgtcctgat caagtagctt 3282481 aaacagctgc tgctcttcaa ttgctgactg gacgccaacg gtatcgtaaa actccagtgt 3282541 cggcgtttcc ataaattgat atccccattt atcaatcaaa tcggttaacg atcgtctcac 3282601 cttttttttc gtttcgtata aaccgggcag tgtatctctc atgccgtgcg gtttttcaaa 3282661 cataaacatc aacccgagca cctccgctgt tatcttatga aggaaaattc cgaatccttt 3282721 agttcgctaa tatgataata tgttagcaga tgaaagaatg aaaatcaacg cttaacttca 3282781 gtaaggatat ttttagttca aatatccttc tcctcattat gaaaaaatca tgaataatgt 3282841 attaaaggta cgtaatatct caaattcttt atgtttggca tgctataata caaatcaaat 3282901 agagaacaag gagataaaga tgaaaacact gcgaactcta tgtgtcctga tgattctttc 3282961 aggcgttatt tttttcggac ttaaaataga tgcaaaagat atagatattc cttttttgaa 3283021 cagccttaaa aaagtggttt ctgatagcga tacagactca gctgcgaata gcaaaaagga 3283081 gctgaaggga agcgcaaaac cgctggatgt catcctttac aatcaaatgg acgcaccccg 3283141 gctctataac ggctgtgaag taacaagcct tgcgatggtg ctgaattatg cgggatacga 3283201 cgtgacaaaa aataccctgg caaatcaggt tgccacagtg cctttgacat acagcagcgg 3283261 attaaagggt gatccgaatg acggatttgt cggggatatg gcgaatggcc ctggtctcgg 3283321 tgtctaccat cgaccgatct atcagctggc gaaaacctat gcgggagaca aagtgtctga 3283381 tctgactgga aaaagtattt ccgctgttta tcagcagctt gaaaaaggca atccagtttg 3283441 ggttattacg acagccaact ttacgccagt tgacaacatg cagacatgga aaacgccaaa 3283501 cggaacgata gaaattacgt acagcgaaca cagcgtcgcc gttacgggat atgatgataa 3283561 atatgtgtat ctcaatgatc cgtatggcta taaaaacaga aaaaccgata gaacaagctt 3283621 tgaaaaagcg tggaaacaaa tgggcagcca ggccgtggtt attcaaaagt aaacacctga 3283681 agcctcacta tgctctattc tgagcaaata cgacaatatt catgcttttt gtatcaatcg 3283741 gtaagatcga ttcattttcc atttttcacc caaaattgtc tttactttca ggctgtctgt 3283801 ttttatgatt aaagcagatt cagccttgcc ccgatctatg cgagagaagc cggtgcaagt 3283861 cgctgacgct tctcttgcaa aaaatgaaag atatccgggg aggatttatc attgaaaaaa 3283921 atcgtgtcta tcctatttat gttcggtttg gttatgggtt tcagccagtt tcagccatca 3283981 accgtttttg cagctgacaa agtggtgcac gaaacaatta tcgtaccaaa aaatacaaca 3284041 tatgacggga aaggacagcg gtttgtggca gggaaagaat taggtgacgg aagccagtca 3284101 gaaaaccaag accctgtttt tcgtgtggag gatggagcaa ccctgaaaaa tgtggtgctt 3284161 ggtgcacctg cagctgatgg cgtgcacact tatggaaacg ttaacattca gaatgtgaaa 3284221 tgggaagatg ttggtgagga tgcgttaacg gtgaagaagg aaggaaaagt gacgatcgac 3284281 ggcggttctg ctcaaaaagc gtcagataag atattccaaa tcaataaagc cagtaccttc 3284341 acagtgaaaa atttcacggc ggataatggc gggaagttca ttagacagct tggtggttca 3284401 accttccacg ttgatgtgat catcgacaag tgcaccatca caaacatgaa ggaagcgata 3284461 ttccggacgg acagcaaaac aagcacggtc agaatgacaa atacacgcta ctctaatgtc 3284521 ggtcaaaaat ggattggtgt tcagcatatt tacgaaaaca acaacactca attttaacaa 3284581 aaaaagtccg ctgatgttat tcagcggact ttttcaatct ttcttgcatt tcttccttcg 3284641 tatagatgat cctcatcgga tttccgccga caaatgcccc gtcaggcaca tccttatgga 3284701 caagcgttcc ggcggacaca actgcgccat ctcctatttt caccccgggc agaatggtcg 3284761 tgttggcacc aatcatcact tcgtccccga tcagaacttt gccgatccgg tattcgtgaa 3284821 tcaaatactc atgggccaga atggtcgtat tgtacccgat gattgtattt gttccgactg 3284881 agatcttttc cggaaacatg atatctggca tcaccatgag ggcaaaggat gtctgttttc 3284941 caaccttcat ccgcagaaat gtgcggtaca gccagttttt catccctata aacggcgtat 3285001 atctcgcaat ttgaatgaca atgaaatttt tgacgacctt taaaaaaggt accgtttgat 3285061 agacatgcca cagtgagttg gcccccgaga ccggatgacg atctgttttt ctcacagatt 3285121 acttcactcc aacgatttgt aatagatcac tcattttctc aagcataaaa tccggctcat 3285181 gcttcgccag catttccggc cctttaatcg tccatgcgac tcctgccgtt tttgtaccgg 3285241 cgtttttccc tgccagcaca tcatggtaat tatcaccgac cataatggct tccgccggct 3285301 cgcttcctag ctgtttcagc gctaacagca caggctcggg atcaggcttt gcattcgtca 3285361 catcatcaag ggtgacaact gtttcaaaga attcgccgat tcccgtgagc ttgaggccca 3285421 tattgacagt atctcttaat tttgttgtca caattcctaa tgtaaagccg gcttttttta 3285481 atgcatccag ggtctcatat accgtttcat attcagtgac gagtgaatca tgcatgtcat 3285541 gattgtacgc tctgtacata gcgatcatat cctcgcattt atcagggtcc atcgaagaga 3285601 acgtatcaaa aagagacggc ccgataaatg caaggacatc ttctcgttta tacttgctcg 3285661 gataataatg ctccagtgta tgcaaaaagg acgcgataat taattcattc gtattaataa 3285721 gcgttccgtc taaatcaaac agaatcgtcg ttacttgttt gtcactcata ttgcttcctt 3285781 tccaaccgct gagggtttcc attttttcca cgtgtgcgca atagccattg tcagcagaac 3285841 tgctgtggtg acacgaatca aaagaagcgg ccagaccggt atgccaagcg gaataaagac 3285901 aagtgtatct tccacgaccg cgtggcaggc aacgagaaat ataaatgcca atgtcatgtc 3285961 ccgcttgctc acgccgtcat cctcgacagc tttgatcatg acacccgctc cgtaggccag 3286021 accaatcgtc agtcccgtca ccatcgtcat agacgtattt ttattcatgc caagcagctg 3286081 cgtaaacggc gacagccacc tggaaaaccg ataaagccag cctaaatctc ttaaaaactg 3286141 gatgataatc atcagcggga tcactattgc cgccagctgc aaaacaccaa gtccggcttt 3286201 cgttaatgct tctgccaaca ttcctagcca gctgtctggc gccgcgctct tcgcagcgat 3286261 aaaaccgtac tgcgccgttt cctttccgcc atgccaaatg aggttgatga cgatggctga 3286321 cacagcggcc aaaccgatgc gcacggccaa tatgacgcca attctgatac caacctttgc 3286381 ggcaactgtc gattcgataa tcaagttatg acagaaagaa agcataacag ctaaaataaa 3286441 gacttctttc acagataaat ccaatgttaa aatcccggca attcccgcat acagattcag 3286501 catatttccc agtacaagcg gaatggccgc ttcaccagaa agcccgaaga gacccattac 3286561 cggtgtgatc agccgtacaa gccaatccat gacaggggta tgctggagca aagtgaccaa 3286621 tagcgttacc gggaaaatca ctttacccag cgtccatgtt gtttgaaaac ctgctgcaag 3286681 accggccaga aagatcttct tcatccctca tccccctttg ttgacgtcta ctccgcgtac 3286741 cgctccttcg agtatccctt gacgcgtctg aagatgatgg ctgccacagc caaaacaatc 3286801 aatacgattg aaatcacctg agcgatgcga agtgaatcag tcagcattaa gctgtcagtc 3286861 cgcattcctt caataaagta tcttccgatt gaataccaaa tgatatagat caagaacatc 3286921 tcgcctctac gcaaattcgc tctgcgcagc agcagtaaaa caatgacgcc gacaaagctc 3286981 catagtgatt catataaaaa agtaggatga taatattgcc cattgatata catttgattg 3287041 atgataaatt caggcaggtg caggttttct aaaaaggctc tgctgacagc ctcgccgtgc 3287101 gcttcctgat tcatgaagtt cccccagcgg ccgatcgcct ggccgagcaa aatgctgggc 3287161 gcggcaatat ccgcaagctt ccagaacgaa aggtttttca ctctcgaaaa cacataaccc 3287221 gttaaaatgg cgccgattaa tccgccatga atggcaatgc cgcccttcca aatcttaatg 3287281 atttctcccg gatgtgccgc ataatagtcc cattcaaagg caacataata aattcgtgcg 3287341 caaataatcg caattggaat ggcaaacagg acaagatcaa taaacgtatc tttctgcagc 3287401 ccccgttttt cactttccct catcgctatc cacagcccga gcaaagcgcc gagaccgata 3287461 atgattccgt accagtggac ggctaacggc cccagctgaa atgctatcgg attgagtggt 3287521 tctatcgctt cattcattta acgccaactc ctattcttct tgttcaccgt cttcaatgac 3287581 gtccgccagc ttgttggtaa attgttcagc ggcattcagc cccatccgct tcaatctgaa 3287641 gttcattgct gccacttcga tgatgactgc aagatttcgg cctgggcgga cgggaatcgt 3287701 cagttttgta atttctgtat caatgatttt catggtctct tcctcaagtc cgagccggtc 3287761 gtattgcttg ccctgctccc agagttcaag attcatgaca atcgtgattc gtttattgct 3287821 tctgaccgcg ccagcgccaa atagcgtcat cacattgata atgccaaggc ccctgatctc 3287881 aagaaggtgc tcaattaatt ccggagcgtt tcccacaaga gtatcctgat cctcctgccg 3287941 tatttcaacg caatcatcgg caacaaggcg atgccctctt ttcacaagct ctagcgctgt 3288001 ttcgcttttt ccgacgccgc tttttcctgt gatcagcacg ccgacaccat atatatcgac 3288061 aagaacgcca tgaattgctg tggtaggcgc cagcctgctc tcaaggaagt tggttaaacg 3288121 gcttgacagt cttgtcgttt tcagcggcga tctgaggaca ggcaccccat ttttctcgga 3288181 ggcgtcaatc agctcctgcg ggatgggcat atctctagaa agaataatag ctggtgttac 3288241 atcagtgcac agagaatcca ttcgctgctt tttctcctct tcaggaagct gttcaaagaa 3288301 agaaagctct gtttttccga gaagctgcac gcgctccctc gggtaatatg taaaatatcc 3288361 ggcaatttca atacctggtc ttgataggtc actcattgta atcgggcggt taattccttc 3288421 ttctccgctg attaattcca aattgaactg ttccattacg tcttttgtgc gaacctttgc 3288481 cacgatatgt tcctcctgtt ccgggctgcc ccgagcttgc tcacaatact ttcattttat 3288541 cactttcggg cttgaaccta aaacagattt tataaaaggg gggaaaacac ctcagctggt 3288601 ctagatcact agtctgaaaa agagtaaaat aaaggtattc aaattccaga aaggcggatc 3288661 atctatggca gagagtcttc ttatcaaaga cattgcgatc gtgacagaaa atgaagtaat 3288721 caaaaacggc tatgtcggaa tcaatgacgg aaaaatcagc acagtttcaa cagaacggcc 3288781 caaggagcca tattcaaaag agattcaagc acctgcggat tccgttttgc ttcccggcat 3288841 gattgacatt catatccacg gcggctatgg cgcagataca atggatgcta gcttttccac 3288901 gctcgacatc atgtcgtcaa gactgcccga agaaggcacg acgagctttt tagccacaac 3288961 gattacccaa gagcatggga acatttctca agctttggtg aacgcaagag agtggaaagc 3289021 ggctgaagag tcctctttat taggtgcaga actgctcggc attcatttag agggcccctt 3289081 tgtttcgcct aaaagagccg gagcgcagcc aaaggagtgg attaggcctt cggatgttga 3289141 gcttttcaaa aagtggcagc aggaggcggg cggactgatc aaaattgtta cacttgcgcc 3289201 ggaggaggat cagcattttg aactgatccg ccatttgaaa gacgaatcga ttatcgcatc 3289261 catggggcac acggatgccg attccgcatt gctgtcggat gccgcaaaag caggggcgag 3289321 ccatatgact catctgtaca acgcgatgag cccgtttcat caccgagagc ccggagtgat 3289381 cggaacggcg ctggcccatg atgggtttgt gacagagctt atcgccgatg gcattcactc 3289441 ccatccttta gctgcaaagc ttgctttttt ggcgaaaggc agcagcaagc tcattttaat 3289501 taccgattcc atgagggcaa aaggactgaa agacggcgta tatgagttcg gcggccaaag 3289561 tgtgacggta agaggacgaa cagcacttct ttcagacgga acccttgccg gttcgatcct 3289621 caaaatgaac gaaggcgcac ggcatatgcg tgagtttaca aattgctctt ggacggatat 3289681 agctaatata acttctgaaa acgcggccaa acagctgggc atctttgacc gaaaaggcag 3289741 tgtgactgtg ggaaaagatg cagatttggt gattgtcagc agtgattgcg aggtgattct 3289801 caccatttgc cgcggaaaca ttgcatttat atccaaggag gctgaccaga tatgaaagta 3289861 atggaatgtc aaacgtatga agagctaagc caaatagcag ccagaataac ggcagataca 3289921 atcaaagaaa aacctgatgc tgttctcggt ttagcgacgg gcggcacacc ggaaggcacg 3289981 tatcgccagc tgatccgcct gcaccaaact gagaatctct catttcaaaa catcactaca 3290041 gttaatttgg atgagtacgc cggactttca agcgatgacc cgaacagcta tcacttctat 3290101 atgaacgacc gtttttttca gcatatcgac agcaagccta gccggcattt tattccgaat 3290161 ggaaatgcag acgatttgga ggccgaatgc agacggtatg aacagctagt cgattccctc 3290221 ggcgacactg acattcagct tctcggcatc ggccgaaacg gacacatcgg ctttaacgaa 3290281 ccgggaacgt ctttcaagtc gcgaactcat gttgtgacat taaatgagca aacccgccaa 3290341 gcgaatgcca gatattttcc ctccatagac agcgtgccga aaaaagcact gacaatggga 3290401 attcaaacga tactctcaag caagcgcatt ctgctgctta tttctggaaa aagcaaagcg 3290461 gaagctgttc gtaagctgtt agaaggaaac ataagcgaag attttcccgc atctgctttg 3290521 cacctgcatt ccgatgttac ggttttgatt gatcgtgaag ccgcgtcatt aagaccttga 3290581 aaggaacatg ctgacttatg aatatcaata aacaatcgcc tattccgatt tactatcaga 3290641 ttatggagca attaaaaacc caaattaaga acggagagct gcagccggat atgcctcttc 3290701 cttctgagcg cgaatatgcc gaacaattcg ggatcagccg gatgacagtt cgccaggcgc 3290761 tttctaattt agttaatgaa ggcttgctct atcgcctgaa agggcggggc acctttgtca 3290821 gcaagccaaa aatggaacaa gcacttcaag ggctgacaag ctttaccgag gatatgaaaa 3290881 gccgcgggat gacaccgggc agcaggctca ttgattatca gcttattgat tcaactgagg 3290941 agctcgcggc tatattaggc tgcgggcacc cctcctctat ccataaaatc actcgggtgc 3291001 ggctggcaaa tgatattccg atggcgattg agtcctcaca tattccgttt gagcttgcgg 3291061 gtgaattgaa cgaatcgcat tttcagtcgt cgatctatga tcatattgaa aggtacaaca 3291121 gcataccgat ttcccgtgca aaacaggagc ttgagccaag cgctgccacc acggaagaag 3291181 cgaatattct tggtattcaa aagggagcgc ctgtcctatt aattaaacga acaacatatc 3291241 tgcagaacgg aactgctttt gagcatgcaa aatccgtata cagaggcgac cgttatacat 3291301 ttgtccacta tatggatcgt ctttcataaa aaaagcctcc aacccttttt aaggattgga 3291361 gacatggcga aaatcaaact ggtctggtgc cggacgatat gtttcttttt tcgtcttgaa 3291421 cttccagatc ggtgatttcg ttttgccgtt aaaactgtct tccactataa tgtaccaata 3291481 ataaacagac tgcggttcaa gatgatccca gcggaattca gctgtgtccc cgctcttcac 3291541 ttgctcccgt tttccgagct cttcattggt atatacgtta cattcaaaat aatcggtttc 3291601 cacctttttg attcttggct tcaaatcaag cgaaagggaa aattcatcct tgttgccata 3291661 ggtatccgta tcatagtagt tcttatcctt tacatacgga gagtacgtcg atacgtgcac 3291721 catgtcattg gcttggtcaa attgaagcaa acgcaaatac ccttggccgc cttctggccc 3291781 gccctgataa tcggccagca tttgatgcac aagacgatcc ggtttcccat caccatcatc 3291841 atccagctca tctgtttttc tcatcgcact atgataatgc ccgctcaaca ccatcacgac 3291901 attcgggttc ggctttacga tttctttgaa tattttctct ccgattgggc ttctgtttcc 3291961 gctgaccagc aaatactcat gaaaagctaa aatggccatc cggtcaggat gcttcttcag 3292021 cacctgattc atccacgcga tgtcttcatc cgtaatgccc catcccatgt acagcatgat 3292081 ataatcattg ccgttgctag aaatcaggtc ataatgtccg cggttatttt tataggaacc 3292141 gccataatga aattttttat caaaacgatc gctgccaaaa tatttgccaa acgccctgta 3292201 ggagccgtcc ttatgtccga catcgtgatt gccggccagc acgccgtaag gaattccgct 3292261 cttatccaga acggacattg accgatcagc gtttttccac tgtctgatat cggcggaatc 3292321 atctacaata tcacccgtgt ggaacacata tttgatattg agctgctttt gattatcttt 3292381 tatccattcg gtctgtttat caaaaatatg cggatagctt tcggcgtaat actgtgtatc 3292441 agacatccag acaaatgtgt acatatcctt cgcaggagga atttcatcct gtacaatcac 3292501 attcattttc gactcccgta caaaatcggc ggcaatcaca gacgctttca gcgtaaacgg 3292561 tttgtcatcc ttcgcgacga agctgtcaac aggctgccat tcgtttgtcc gataattcca 3292621 agcatacatc gtcacctttc tccccggcaa agaactgccc ttccagactg attctgccag 3292681 atcattctca tcaattgatg gatcaaccgt cacttcaaag cgatgataag ggaaaagctc 3292741 tttgttttct gtcgatactg tttttccatc agcagctgat acccgctcca attctttatt 3292801 cgtaaatggg gtctcccttt ccggcacaaa gcttttcggc ggttcagtca gtgacgcgtg 3292861 cttaaatatt ttcacatgat tgcgcgctgt atattgaaat cccctataaa aaccaacatc 3292921 catggcatca ttcgtcggat ctttcacccg tacagaaagc ttggccttat gcgtgtcggc 3292981 ttcgctgtct ataacctccg gctggtccgg atgctctcgt tcggttttaa atatcctctc 3293041 aatcactgtt ttattgcccg cgagatccgt tgctgtcact tttagagaat gttttcccgg 3293101 caaaaggtca gaagatgacg tatgatatgg gagtgtaatg ctttctccat ctaacgacgc 3293161 ctccgcttcc tcaattctgc tccatttatc atacatatcc gcctgcagga taaggtttcc 3293221 tttatacgtt tgcccctcgg tgatattcgg ctcaatgtga ggtcctgaat tatctacccg 3293281 tacaaccagg ctgacatttt ccttcccgtc gcttgcttga atatggtgag cgccttcaga 3293341 aagctttgat gtatcccact ccagcagctg tgatgtaaat agtccgtcag gcagattgaa 3293401 ctgaaattgc cagcttttat tcgagcgctg attatcgcca ataaagagtt ccttctcagg 3293461 agacaccctc tgatctctga tcaccgttcc atccgataac accaatcggg cgtttttgac 3293521 taagaagtca tcacggtttt cagccgtatc aaacggagac accttcgaac ctgaacgtat 3293581 cgtaatacgc tgcagctgct tccctttccg aagcagtgtc tctggcaatg gaacagaata 3293641 ggtgcggtat ttatttgttg tatcatcgaa caccttcagc actttgcctt ccatcgttac 3293701 cgcgttttta aaataaaggt tcgttttcct cgtatcgaat gcaaaatata cttctttttc 3293761 catcgcgggc tctgtcactt gttttttccc gtcaatccat agcttaatgc tgtcagctcg 3293821 cccttctgtc gtggctttga gaaattgagt tcccgacagc gtgtctctgt tttcaatatt 3293881 catccgcaga ccgtgcgcct tgcttgtttg tttaatatca atcattttga ccggcgttct 3293941 cgcttcattg atcccgtccc cggccgccac ataatactct agctgatcct tcccgatcaa 3294001 ttcaggcgaa tacacaatat aatggaagag attatcgttg cggtcttttt cagcaagaat 3294061 tcgcttaaac ggtttgttct catccgtccg gtagtaaaag gccactgttt tcactaggct 3294121 tcggtcccgt atgtcagccc gcagctcaat gctttcagca gggcggacag gcttgcggtc 3294181 agtcaaatcc tcaatgaccg gcttttcttt atcgagcttg attttccgtt tctggtcggg 3294241 cacctgtgcc tgtaatacgg ttccgggaga cggattcttt tccccgattg aaatgttcag 3294301 aagttctgct gttccgttca gtggatactt ataaagcact gatgacagcc ggcgcagcgc 3294361 atgtttccga taatgcgcaa ccgaaatgtc ctttcctgta ttcgttgata tcacaacggc 3294421 ccgcggcctc gtattggcca taccctctgt ctcgtctatc accgcaagat tttttccttc 3294481 ttttagttgt gtctgataat aacgattgaa atccgctgac gtcaattctg gatgcccggc 3294541 aggcttcagc cagacgacaa acgtttcgcc ggatggtatc aagatccttt catcaggtct 3294601 ccaaatcaga tcggagtcag gcccttcttt tgggtagcgg taacggatat ggtagtcttt 3294661 aaaatcaatc gttctgtcag tcgtattaaa aatctcaata aattcataac cgtctgcgcg 3294721 tcctatattc ttcgtatcaa ccgccagctc tgtgatcaga agctccggaa tatgggcaag 3294781 gtcagcctgg tatccttcaa gcttcagttt cttcgtctcc gactcaaccc gctgcttccc 3294841 attcgacatc acaatgtaat actcaagctc gctgttccaa atcaaacgtt tcggaatttg 3294901 tgccaaaaac ttgcggaccg ctccgggggt cgggtccatc ggcaccattt tgtagcccag 3294961 ctcattactt tgtttataaa aaagaaaggc ggaaaatgct tgatacgaat tatcgcgaac 3295021 ttgagcctca atcattagat tgcttctcat ttcagctttc acatcaattt gaggaggatt 3295081 ttcaagcaag ggtatgtaat gaggcgtttg aaatagttcc tgctgtacaa caggaaaagc 3295141 tttcgattca tgatggccgc cagacaaaac ggaaagaaaa gacagtaata tagaagcaat 3295201 aaccgtgtat ttcctcatca aagcacctcc cttttcatgt attttgcgtc tgaacaggga 3295261 agcttatgag ttcatttttg tgcataaaga acaaaaaaac gtctgtctct tgaaaattcc 3295321 actattaccc agtaaactaa ggatagttaa ccagttaaca attaaatcag agaggcaaat 3295381 tgatggacaa cagcattcat gatgaattat ttcaagctat acaacaattc gcattaaaaa 3295441 gggataaacg cgtctggcaa aaggtgcaga taccatccat tggcatatcc tcacaacatc 3295501 acgatcacct caaaaaagac tggactttga cccagcttca cattgtttcc tgcatacata 3295561 ccagccaaaa tgtgaacaac agcttcttag catcccgttt acacatctca aaagccgctg 3295621 tttcaaaagc ggttcatgct ttgttgaaac acaatatcat tacagtgaca aaaaagcctg 3295681 gcaacaaaaa agaaattttt tatacgctaa ctgatagcgg cagaaaattg gcggcattac 3295741 atgaacagct tcatgagaaa gcaaaggagc aatataaaca gcttttcaat gaattttcaa 3295801 ttgatgattt aaaaacagtg actgcgtttt tcaacttgtg gatcaaatat atgtaaaaag 3295861 agtctcaccc gcatgggaga gacctttgga attctattat gccccgtcaa acgcaacgag 3295921 aagtgaaaca ggtccgcgtg tatacagacc ggactcagca taacaaaaat cttcctctaa 3295981 tctgatattc cgcatcttat ccagcacaat attagctaca atttcgattt cgtttttggc 3296041 aaaagctgct cctacacagt tatgaatgcc ggatccgaaa gcgagatgcc gggcggcgcc 3296101 gctaaaagcg ctcttgatac caagatcttc ccgatgaata ttaaacacgt caggctgttc 3296161 aaatgcttca gggtcccggt tagccgcacc gatcatacaa aaaacaatcg tatctttttt 3296221 gatttccata ccgccgacca ctgtatcttg ggacagctgc cgcggaatca gctgaaccgg 3296281 cggtttataa cgcaatgtct ccgcaatggc tctcggaact aacgaacggt cagccaaaac 3296341 atcattcatc tgctcaggat tgttgagcaa atggtagatc atcagtgcca gcgtcttatc 3296401 agccggttcc gttgcggcta acagcacatt aagaatcagt gcgagtatat ccttgtccga 3296461 cagcgccatg ccttcatatt cagaagtaca taggatcgaa attaaatctg atcccggatt 3296521 gacgcgacgt tctttaatga ccggcatcaa gtattgggaa agctgttcgc tgcaccataa 3296581 cgaatgtgcc cgcgcttcag gagattgaga gatactcgtg ataaaatcgg caactccgct 3296641 gtgccactca gagatttttt catggtctct tttatccagc ccgagcatgt ccatcgtgac 3296701 gcacaccgca aacgtctttc caaaatcatt gacgagatca cttttccctc tttcaagata 3296761 aggcgctaac aagttttctg cattttgttt aatcaatgga gacagatgat ccagtgcgtc 3296821 accgataaag cttctcacta caattcttct tttggcagag tgttcttttc catgcatttg 3296881 ggccagcaca gggcctcgca tgactggttc ggcacgctca acaagtgatt tcgtcgtgaa 3296941 gatatccgga tgctgaagga tatagcggac atcatgatag cggctgataa aataactgtc 3297001 tatcgactct tcataatgaa ccggatcttc ctcccgcagt tgtgaaaaat aagcatatgg 3297061 attgttttga aattgatcag aaagcacact aaacaattta atcgattggc tcatgtttta 3297121 ctccccctat catccttcag atgtgatccg tttctcagaa agcatctgcg ccatttcctg 3297181 tacaatgaga tacccttgat tcggccgcat acaaatagaa aattcatggt tactgatctt 3297241 ctcacccagc ttccacggac gatgataagc aaggagtgtc tcttccacct ctaaaatatc 3297301 cggagctccg ataaaaaacg gcagctcagc tatgacatat tccacagcca aattcagcat 3297361 atcctcactg acttcttcca tcatcaaact gacgccccgc gcacgcccga ttatcgcttc 3297421 acgagacatg tccaaacaag catgtcgaaa atgaggctgc tcaaaaaatg catgttcaac 3297481 ttcttgtctc aacagctggt aggctttgtt atctataaaa tcagaaaatg tatgaatcgc 3297541 cttcggatcc ccgccatgag ccacaagggc tctttctgca aatctcctgt ttcgtgatac 3297601 ctctttcctt acttttcgtt cagcctttcc tctcggagtt ccaagcgctt ctagaagatt 3297661 agccgcctca tgccctgcaa gtaaaactga aacgctttta aattgagctt tcgcccatcc 3297721 aattaatctg taaatataat cctctgaaaa cctgctgtta aatgggctga tccccaccaa 3297781 aacatgcctg cgccgttcaa atatttctct gcagttttct gttaatgcct cagcaataaa 3297841 atgcacagac cttctttccg ttaccattcc ggtcatctca ttcaccccta aaacttatcc 3297901 cgctttaagt catcaccctc aaatacaaga tggaatagct agaacaactg aacaagacga 3297961 atggcaggca tcacttaaag tttccaaatg ttttttaaga ttttaataat cattttcaat 3298021 acccatatca tgataaatgt ttactagtaa acattagtca ttttatccct tttccttcca 3298081 aacgtcaata tgatctgtgc ccaaatattt gaaaataaat gtaaacatca cattttccac 3298141 acacttttta cacgcatatt cagcatgaca tatcaacaaa tagtctaaac accaacaatt 3298201 gacaacgaaa acaagaaaag ataaaataaa attgttcacc agtaaacgat ttgttttatt 3298261 gtttcatcgt aaactattat tcctaagaaa gaaggtagcc tatgtctgat ttgacaaaac 3298321 agatgatata cgacatatac gtgagactgc tgcaccttaa tgaacaaaaa gcgaacactt 3298381 cacttcagca attttttaag gaggccgcag aagaggatgt agctgaaatt cccaaaaata 3298441 tgacaagcat tcacgtcatt gactgcatcg gccagcatga acccattaat aatgccggaa 3298501 ttgccagaaa aatgaactta tcgaaagcga atgtaacgaa aatcagcaca aaactgatca 3298561 aggaagaatt cattaacagc tatcagctga cagataacaa aaaagaagtt tattttaaat 3298621 taacccgtaa aggcagacgg attttcgact tacatgagaa actgcataaa aaaaaggagc 3298681 tggcttttta ccaattcctc gattcatttt cacaagaaga acaaaaggct gtattgaagt 3298741 ttctagagca gttgacgtca acacttgaag cagaacaaac cgatgggact ccagacaaac 3298801 ctgtaaagta aacaaaaagg cggtgtacac tttggctcat acaaaatcaa aggcagtatt 3298861 gatcttatac actgtttgct tcagtgcatt ttttgcatct ttaagccaga acatttattc 3298921 acctattctt ccgatcatta aagaatcatt ccatgtttcc acagctatgg tgaacctgtc 3298981 agtctcagtt tttatgattg tgacagcaat aatgcaaatt atattaggag cgatcattga 3299041 ttttaaaggc gctcggatcg tcttgattac cggtattctg gcaacggcag cagccagcat 3299101 cggctgtgcg gtgactactg actttacctt gtttctgata ttcagaatga tacaggcagc 3299161 cggttccgca gcactgcctc ttattgctgc cacaacgatc ggacagctgt ttacaggaaa 3299221 tgaacgcggg agtgcaatgg gaacgtatca aatgctcctg tctgtcgcac cggctattgc 3299281 tccagttcta ggaggattca taggcggagc agccggatac gaagggattt tttggatact 3299341 tgcggccatc tctatcgttt tgctggtgac aaacagcatc acctttccta aagattctcc 3299401 aactgaatct atgcagcaag ccaaaggcaa tgtgttcgct cattataaat caatatttac 3299461 aaatcgaaca gggaacgtca ttttgacttt aagttttgtt ctctttttca tttattttgc 3299521 agtaattgtc tacctcccaa tattgctgac agagcattac catatagatg tgggtatagc 3299581 aggactgtta tatttgccgc tggcgctgag cacgattgca ggtacgtttc tgtttaaaag 3299641 aatacaggca aaaatcgggc tgcacacctt gtttatcgga agcaatgtga ttgccgcctg 3299701 cagcatcatt ttatttgctg ttacacattc cgtttctctc gttctcatgg ctctgacgct 3299761 ggcactgttt ggcatctcga tgggggttat tcctcccttg tactctacaa tgattactaa 3299821 tgaatttgag cacaacagag ggagtgcaat cggaatgttt aactttatcc gatatacagg 3299881 catggcagca ggtccgatgg tatctgccta cttgctcaca atgatgccgt ctgccatgtc 3299941 ctttagcctc ctaggccttg gatttgccgc attgagcttt tgccttcttc cgccaatgtt 3300001 ttcgccgcag aagcgcacga aacaaaaaaa gcaccacatg taaaaaagct gcctttgcgg 3300061 gcagcttttt ttattttttt ctaagcggct ctaaaatgcc tttttgaatc agcaaatgga 3300121 agaccgacag gataacggat gcccatatcg ctgtgccgaa gccgtcgatt tgaaagctgt 3300181 cacccataat ggacgcggtc atcataagcg tgatggcgtt aatcacaaac aagaagagtc 3300241 caagcgtcac catggtgacc ggcagtgtaa atataattaa aagcggttta atcagcacgt 3300301 ttaagatcga taaaatgagg ctggcgataa tcgctgcccc aatgctgctg atatggatgg 3300361 agtcaatata tccatcaatg acgattaata acaatgcatt gactaaaatg ctgactgccc 3300421 attttaccat gtcatttcat atccctttct gacgggacga taaaaatcca aatgatataa 3300481 atgagcaaaa ccggcaagac acttgtcata atggctaaga tgacagttat gactctgagg 3300541 agtgatgcgt cccaattgaa atattccgcg agacctccga taacaccggc gattttctta 3300601 tttttttctg agcgataaag cttattcatt cgatcacctc tgtgagtact ttagtttgat 3300661 ggcgcctgtt agtgattctg agaagacggt gatgttttga tcatgtgcct gatttgaagt 3300721 gaacatcatt tctttttgaa tcgtatcatt tttttccttc agcatctcta catccattaa 3300781 ttcatgggac agcgtaccaa gattgctttt cagctctgcc ttcactgcga gatcgtccgg 3300841 aattgcaagc tctacatttc cagtcgttgt ttttgcataa atggagcggc agtctgattc 3300901 tgttacgtta atcgcaatat ttccgttaaa gctttgaacg tcaatggatt cgcttttccc 3300961 tcggagatcg atcaatccgt taatggtttc cgcttctatc gtaccgcagc tgtggcttgc 3301021 gagcttaatt tgcccgttgg ccgtttcagc tatggctttt tcggctgtta aatacgagaa 3301081 cgacagcacg ccgtttgtcg ttttcgctga gaactctttt acatgtaaat gttcccctct 3301141 gactggaccg ttaaacagct tcacccgaat cttatcatac tccttctgag gaatatacaa 3301201 agtgacattc gttttcatcg tctttttctc agtacggata aaaaacttat tacctttgat 3301261 ttcacattca atatgctgaa gaaatgcgtg tctcgccgca tcctggctgt cagcgcgata 3301321 taccttcgcc tggcattccg ctctgatatc gtcatcttcc caagggacga tatttacgct 3301381 gccattggca atttgcagct caacactgga aaagtcagta tctttaaatt gaaaaatgtg 3301441 ctgaacatca tacgcatggc caaagtttaa atcaaggtca acttccttga cctttttcac 3301501 agcagaatca atccagtcaa acagcttggc tcctaaagac ggtttgccgc tttctttttt 3301561 tgccgttgta aatggctctt cctcgtcatg aacgtgaact gagagcgctg tgattttctc 3301621 ttctttttcc ttgtagtcgc tgtcaagctt ttcaatcagt gtcaaagctt cttgtgctgt 3301681 aagctttcct tcctcaacaa gcttaaggat tcgttccttt tcttgcttca ttacgatctc 3301741 ctccccattg tctacttatg ctgcacgcag gaccttaatg ccctgaatca cattccaaat 3301801 gataatgcca atgacaacta agaaataaat aaccgctccc ccgatgatta caaatacagg 3301861 aagcaagctg tctccatcaa tcgcaacggc tccgccaagt aaagcaataa aaaggaacag 3301921 ccagccgaca aacggaacaa tgtgagaaat aagagagcgt atcgcatggc gttttgtttc 3301981 tttctcattt acaacaaaat atgcgacaat cggcacaatg attggcgcaa tgaacacact 3302041 gaaataacaa agtgatgcaa taatagcttg attacggttc aattcattcc acactcctat 3302101 tgtgaattgt ccatgacaaa agatcaggga cgttttactt atttatacgt ttaaaatctc 3302161 ttcaggtttc aaattcattc tttagacatg ctccgattta cggaaattgg attttaaaaa 3302221 gttttagaag tagaatcttc cggctatacc gattacaata tgtaaaaagc ttacggcaac 3302281 caaggaggct ggacaagcaa tggagaaaga tcccagtgac tatacagtaa cacaagaatc 3302341 agtgttaaag ctgattcagg aacaaaaaag aatgaatcgt gaaatgatca ccgagcttga 3302401 gcagattcac ggacccttcc cgatctctca cgatatccaa tatataaaag tgctgctcga 3302461 cagcagcaac acacatattg ttcaagattt aatgagtgta agtaagcagc tgtataagaa 3302521 gactttgtaa ttgcggaaaa catatcattc attataactg aaacaaagct aaaggttaga 3302581 tgacaatatc ttgccttttt tgttttgaaa aaacaagtga ttccctggct gtcacaaaat 3302641 gattgtaaca aaaaaagcct gccggcacat ccagttaatg gactctgtcg gcaagctgta 3302701 actatcagaa agagatagcc gttcaaaatt aacgtaacaa ttgaagcacg ttttgcggct 3302761 gttggtttgc ttgagcaagc atcgcttgag aagcttgaga aggaatgttg ttctttgtga 3302821 actcgctcat ttctttcgcc atgtcaacgt cacggatacg ggactcagca gctgtcaggt 3302881 tttcagaaga agcaccaagg ttgttgattg tgtgctctag acggttttgt accgcaccaa 3302941 gtttagcacg ttggtttgag acattgttga ttgcagtatc aatactttca agttgtgtat 3303001 caaaaggagt attagcaaaa tctgttacat taagtgcgtt tactcctaaa gcagttgatg 3303061 acatgctgtc aatgttaact gtaagctgct ggccagcatt tgctccaatt tggaaagtga 3303121 aaccatcagt ttcagtacca tctaataact ttttgccgtt gaattcagta cgatttgaaa 3303181 tgccatcaac ttcctcaata agcgcatcca tttcatcttt aattgcacca agatcttctg 3303241 cttgttgtgt acctgtgttt cctgcttgaa cagtaagttc acttctaaac ctattatgcc 3303301 gtaaagaaaa agcttgcctg ctaagcccaa ggatggactt gccgacaagc tgtcccctct 3303361 taacagaggg ttttaagatg tagctgtttc ttttgctttc aagagcgatt tcatgcgtgt 3303421 tttgtcacgt tcgataacag gctttaaata acggcctgta tacgattctt caacttcagt 3303481 gatttcctca ggcgttccag acgcgacaat ggttccgcct ccggctccgc cttccgggcc 3303541 caaatccaca atgtaatcgg ccgtcttaat gatatcaaga ttgtgctcaa taaccagtac 3303601 agtgtctccg ttgtctacca accgttgcag cacgacaaga agcctggcga tatcgtcgac 3303661 atgcaaacct gtcgtcggct catctaaaat gtagagcgta cgtccggttg agcgtttgtg 3303721 cagctctgac gcgagcttca cgcgctgcgc ttctccgcct gacaaggtcg tcgccggctg 3303781 gccgagcgta atataaccta aaccaacatc ataaagggtt tggagcttgc gtttgatttt 3303841 cgggatattt tcaaagaaag aaagagcatc ttcaaccgtc atatcaagca catcagagat 3303901 gctttttcct ttgtacgtca cttcaagcgt ttcacggtta tagcgtttgc cgtgacacac 3303961 ctcgcatgga acgtatacgt caggaaggaa gtgcatttca attttaataa tcccgtctcc 3304021 gcggcaggct tcacatcgtc cgcccttcac gttgaagctg aaacggcctt ttttatagcc 3304081 gcggaccttc gcttcatttg tctgcgcgaa tacatcacga atgtcatcaa atacaccggt 3304141 gtatgtcgca gggttggatc tcggcgttct tccgattggc gcctggtcaa tgtcaatgac 3304201 tttatctaaa tgatccaaac ctttaatctc tttatggctg ccgggcttcg ctttcgcttt 3304261 atgaagcttt tgcgccagcg ccttatgcaa aatttcatta acgagtgtac tctttcctga 3304321 accggaaaca cctgtaactg ctgtaaacgt cccaagcggg aacttggcat tcactttttt 3304381 caggttgttt tctgatgcac ctttaatttc aatgtaacgt ccgtccggct ttcttctttc 3304441 aggaggcaat gggataaact ttttccctga taaatagctg cccgttaatg aatttggatc 3304501 ttccatcact tcttccggcg tacccgcaga tatcacctgt ccgccgtgaa tgccggctcc 3304561 cggtccaata tctattaaat aatctgctgc catcatcgtg tcctcatcat gttcgacaac 3304621 aatcagcgtg ttcccgaggt ctctcatatt tttcagagcg ctgatcaagc ggtcgttatc 3304681 acgctgatgc agaccgatag acggctcatc taaaatataa agcacaccgg ataaacgcga 3304741 gccaatttga gtcgccagcc tgatgcgctg cgcctctcct ccggacaatg tacccgctgc 3304801 cctgctcaat gtcaggtaat cgaggccgac tttgtccaga aagcttaagc gctccacaat 3304861 ttcgcgcaaa atcaaattgg cgatctgcat atccttctca gaaagggtaa gatctttaaa 3304921 gaaggcaagt gcgtcggcga cagacagctc ggtaattttc ccaatgtggc ggccgtcaat 3304981 cagtacggca agcgcctctt tctttaaccg atagcctttg cacgtcggac aagacttctg 3305041 agacatatac tgctccattt gctcacgtat gaaatcggag cctgtctcct tatagcgtct 3305101 ttcaatgttg cgcaatacgc cttcaaattg aatttcacct tcgcggattt gtccaaaatc 3305161 attttcatat cggaaataaa tcaggtcatc cccgctgccg tacagcactt tatccagttg 3305221 atgcttcggc aaatctttga ccggcacatc catatcaatc ccgtagtggg tgcagactgc 3305281 ctcaagcagc tgaggataat attgtgagct gatcggtgtc caaggggcga ccgcattctc 3305341 cttcaatgac aaatcttgat tggggatgac aagatcggca tccacttcaa gcttcattcc 3305401 gagaccgtca cacgtcggac acgccccgaa cggactgtta aacgaaaaca gacgcggctc 3305461 aagctcacca attgaaaatc cgcagtgcgg acaggcatga tgctcgctga acatcagctc 3305521 ttcctcaccg atgacatcga tcataacccg tccttcacct aaacgaagcg ccgtttccaa 3305581 tgaatctgac agccgggctg ccacgccttc tttcacgaca atccggtcaa tgactacctc 3305641 aatggaatgc ttcttgttct tttctaattc gatatcgtcg gaaagctcag ccatctcgcc 3305701 gtcaattctg actctgacat agccttgttt cctaatctgt tcaagcactt tgacatgagc 3305761 gccttttcgg cccgagacaa tcggcgccag cacctgaagc ttcgtccgtt ccgggtattc 3305821 cagaattctg tccaccattt gctcgatggt ctgggatgta atctcaattc cgtgttccgg 3305881 acaatgaggc ttccctactc tcgcatataa aagacgcaga taatcataaa tctcagttac 3305941 cgtaccgaca gtagacctcg gattgcggct cgttgttttc tgatcaatgc tgatggcggg 3306001 agagagcccc tcaattgcat ccacatccgg cttatccatt tgccctaaaa actggcgggc 3306061 ataggcagac agcgactcga cataccgtct ctgtccttca gcatatatcg tgtcaaaggc 3306121 aagggaggat ttacctgatc cggacaaacc cgtgacaacg acaagctgat ctctcggaat 3306181 cgttacatct atatttttca ggttatgcgc cctggctccc ttcacctcta tccgatccat 3306241 agccatttgt tcatcatcct tccgctttta gctctaaaag taaatcgcga agctccgcgg 3306301 ctctctcaaa gtcaagcgcc ttggcggctt ccttcatttc atgctccatc tgttcaacga 3306361 ctttctggcg ttctttcttc gtcattttcg acagcttcgg cgcggctttt gttttgtatt 3306421 ccgctttatc ctcagctgct actgtggcac gaatgacatc gcgaatttct ttatttatcg 3306481 ttttcggcgt aatgccgtgc tcttcgttaa accgctcctg ctgctcgcgg cggcgttttg 3306541 tttcattaat cgcaatttcc atagacttcg ttattttatc ggcgtacata atgacgcggc 3306601 cttccgcatt tctcgctgcc cgtccgatgg tctggatcag cgaccgctcc gaacgaagga 3306661 aaccttcctt atccgcatcc aaaatcgcaa caagggatac ttcgggaatg tccaaacctt 3306721 ccctcagcag gttgatgccg acaagcacat cgtacttgcc aaggcgcagg tcgcggataa 3306781 tttcaatccg ttcaagcgtc ttgatctcag aatgcagata gtttacttta atgccgattt 3306841 cctttaaata atcggtcaga tcctctgaca tcttcttcgt caaagttgtc acaagcaccc 3306901 gttcattccg ctcgattctt gcttgaattt cgccgatcaa gtcgtcaatc tgaccttcga 3306961 ttggacggac gtcaataagc gggtcaagaa gccccgtcgg acgaatgatc tgttcgacca 3307021 tttcatctgt atgttcaatc tcgtacggcc ctggtgttgc tgatacatac acgatattgt 3307081 gcatatgctt ttcaaattcc tcaaaacgaa gcggacggtt atcaagcgct gatggaagcc 3307141 ggaagccgtg atccacgagc acctgtttcc gcgcctggtc tccgttaaac atgccgcgca 3307201 cctgaggaat tgtcacatgc gactcatcca ccacgatcat aaaatcgtct gggaaataat 3307261 caagaagcgt atacggcgtt gaacctggag gccgcagagt caaatgtctt gaatagttct 3307321 cgatgccgga gcagaaaccc atttcacgca tcatttcaag atcatatctt gtccgctgct 3307381 ctaaacgctg cgcttcaagg agctttccgt tttcatgcat gaccttcagc tgctcctcaa 3307441 gctccttctc gatattttga atcgccttct ccattttctc ggcccgcgtt acgaagtggg 3307501 atgccgggaa aatcgcaaca tgatctcggt cgccgagaat ttctcctgtc agcgcatcta 3307561 cttcccgaat ccgttcgatt tcgtcaccga aaaattcaac tctgacacaa tgctcatcac 3307621 gggatgccgg aaagatttcc actacatccc cgcgcacacg aaatgtaccg cgctgaaagt 3307681 cgatatcgtt gcgggcatat tggatgtcta caagttttct gagcagctcg ttgcgctcaa 3307741 tttccatttc agtccgcagt gacacgacca tttcccggta ttcctcaggc gaaccgaggc 3307801 cgtatataca agacacactc gcaataataa tgacatctct gcgctcaaac aaagctgatg 3307861 tggcggagtg tctcagttta tcaatttcat cattaatact agcgtctttc tctataaatg 3307921 tatccgtttg aggcacatac gcctccggct gataataatc atagtagctg acaaaatact 3307981 cgacagcatt gttcggaaaa aattccttga actcactgta aagctgtcca gcaagggttt 3308041 tgttatgggc aatcacgaga gtcggcttat tgacttcttt aatcaaattg gacaccgtaa 3308101 atgttttccc agttcctgtt gcacccagca gagtctgatg cttcttgccc tcctgaattc 3308161 ctttcacaag cttttcaatg gctttcggct gatctccctg gggctgatat ttcgagacta 3308221 actcaaagcg atctttcaca aaaataagcc tccgtttctt taacgaaatc ttcctataga 3308281 tatagtaaca caatggaaag caaaatcact aaaaatacga actaaagttc ggtggttttt 3308341 tatttccagc tgtttttgtg tataaaaaac ctgcttttaa aacgtaaaag caggtattca 3308401 gtctttatat tcattatgtc cgatttattc ttcttttttc tctgcagctt ttttggccat 3308461 atacagtccg ccagccacaa gagacacaac atccaatcct acaataaaat acgtttctgt 3308521 atagcctttt aaataagagg caaacagcaa tgcagctgtt aaagcgatcg ccacataatg 3308581 attaaaggtg actctagtaa atagaacaac aagcataaaa gggaaaaaca atgcaaaaac 3308641 ggcttttgta atcaacaaaa accctcctca gggattcttc atctgatctg attatagtaa 3308701 aaaatgaaga atcggacaat cgtgcattcg ctccctctac ttacaccata ccccttttca 3308761 gccaaaatca atcaccatat ttgcattttg gtgccggtca aaacttattc catggtgccg 3308821 ctgttctaat cagcggcact ttttttatta catcatcaag tccgccgcca gattccgaga 3308881 ataaaagaaa ataggcatac agtaccagta cggccgcatt tttcaggata atataaccaa 3308941 cttaactatt cattttattt aggactttct gcgtttgaca gcattttcct gaaaacctac 3309001 aattaaatga tagtgtttac tatcattttt taaacacagg ctccgcaata aaaagactag 3309061 agagaaaaac aaaatgaatg aagaaaagag gggtttcaaa tatgtattct gttttatttc 3309121 gccaggcaga agagtccagc cagctggctg gagcaaaagg aatgaatttg attaaattga 3309181 ccaaacacgg tcttcctgtt ccggacgggt ttattattca aacgaatgcg ctcgcacgtt 3309241 ttatggagga caaccagctt caagagacta gtgaaaacgt cgaaggcggg atcatttccg 3309301 gaacattttc ggatgagctg aaagatgagc tgactagttc cttttataag cttagagaat 3309361 catatcgatc cgtagccgtg cgttcttcgt ctgcttcgga agatttagaa ggcgcctcat 3309421 tcgcgggtca atatgaaacc tacttaaata tcaaaacaga ggaagagttt ctggctaaag 3309481 tgaaagaatg ctgggcctca tttttttctg ggcgggtcag cagctataag aaaaaaatga 3309541 acaatcaaat cgcagagccg ttaatgggaa tagtcgttca ggggctgatc gattcagaaa 3309601 tgtcaggtgt tatcttcagc cgcaaccctg ttacccatga tgatagagag cttttaatca 3309661 gcgccagcta cgggttgggt gaagctgttg tttcaggaaa tgttacccca gacacgttca 3309721 ttgttaataa atcttcgttt gagattcaga aagaaatagg tgcaaaggaa atctacatgg 3309781 agtctgcggc agaaggaatt gctgaaaaag aaacgagtga agacatgcgc agccgttttt 3309841 gccttacaga tgaacaagtg attgaattgg ctgaaatcac aaaaaaaacc gaagacctgt 3309901 acggatatcc tgttgatata gaatttggaa ttgctgatca tcaaatatac cttctgcaag 3309961 ctcgcccgat tacaaccatt gatcaggaca aaaaagcggc agaagaaaaa cgcagcttca 3310021 tgattaccga cactgatatg aatgatttct ggcttaacat ggagtctaat attgaaggtc 3310081 cggtgagtcc gttattttca tccttcatcg tgccggcatt ggaatatggc ttgaagaaga 3310141 gcatgcaaaa gtttccgatt ggtgtagttg ttgatgaagt aaaactttat cgcggacata 3310201 tttattccaa aaaccaaggc ggacagcagc ctccttctga agactgcggc aaagagcttt 3310261 tcccgatttt atcggagcat atgtatgaca tcatcaatca cacatacctc cctttttacc 3310321 ggacactgga ccagctcgca caaactgagc ataccgcaga aagcgcactg gaagcttttc 3310381 aaaaactaaa ggccttttat ctcacggctt atgaagagca ctttaatatc gttttcccgc 3310441 aaatcctttt aacaaacaaa ctgcaagcga tgtatcagga cattcaagga gagtccgaaa 3310501 acgctcattt ttacgagatg ctgacaggaa aaatgaacaa atcactggaa acggaccgtt 3310561 gcttatggct attttctgtg gaagttcagg agaacccgaa ccttctggcc atttttgaaa 3310621 acaacaagcc tgaacagctc caggagaaat tggaacaaac agatgaggga agacacttcc 3310681 tgaagaacgt ccatgaattc ttgcaagaat acggatggag atctgttaaa agtcatgatc 3310741 tgattgaaca aatctgggtg gaaaatccgt atttcgctct ggccaatatt caaaattatg 3310801 tccgtaatgg ctatcatttt gacaatgaat ttcagaaaac aaaagaaaaa cgagagaaat 3310861 tatacaatga attcttggaa agcatagaag atcccggttt acgcaccgaa tttgaccgct 3310921 attatcaatg gacactgaac tctgcaaata taaaagatga tcaccacttt tatattgacg 3310981 ccatgctgga tgccaaggcg agaatctttc tgctgaagat aggtgaattg ctggcggaaa 3311041 acggtgtcat tcaagatcgg gaggaccttt ggttcttata tgacgacgaa gtggaacaag 3311101 cgcttcttca ccctgtatcc ctgcaagaaa aggctgaaaa acgcagacag atttttcatg 3311161 agtatgagct ggcccaagcc ccggcctacc tcggcacccc gacaaaagaa cagctcaaag 3311221 cagctgaaga aattgtcggc gctgtgatag aggatgaaaa aaacacagag aatcatattt 3311281 ttggcattgc ggcatcaagc ggcattgcga caggtccggt gaaaatcatt cgggacgcca 3311341 atgaattttc tcaattcgcg cctggagacg tactcgtttg caagatgacc acaccgctat 3311401 ggaccagcct gtttcaagac gccaaagcga ttattacaga cacaggcggc attttgtctc 3311461 acgctgcgat tattgcccgt gaatacggca ttccagccgt tctcggcaca cgcacggcaa 3311521 ccgaaagact gcgagacggt gacatcatca ctgttgacgg aagcagcggc aaaatcacag 3311581 ttgtcagccg gtcctgatgc gtccccctct ttcttataca agcggggcgg gtgtatactt 3311641 gtcctgccag tatattcgtg aggtgaaacg tattgagacc gacaaacaag agaatccttg 3311701 atgctgccat gcagctgctc gtcaaaaaag gatatcgcgc aacgactaca aaagaaattg 3311761 cagaaaaagc aaatgtaagt gaagcgacga ttttcaggaa ctttaaaaac aaacaaggac 3311821 tagttgaggc tttgctttct cagcattctt caaacagagg cagcattttg gaacaaacag 3311881 aaggggattt gtacaaagac ctgcttcata tcggaacctg tctcttggag gagctcgaac 3311941 atagaaaaga tatcattaaa atcagctttc gtgaaccggc catgtttcag gatgtcatta 3312001 accacgtcac tgaatatccc caatctatga aacagctatt ggttgattat ctcaaaacga 3312061 tgggtgagaa aggggttatt cagacaggaa atgaagcgga acatgccgac gtgttcatgt 3312121 cgattatctt cggttatttc attcaccgtc tccacttagg agaccgggtc atatcaatgc 3312181 cccaggaaaa aatgctggag catagcacag ctctatttgt caaaggaatt tctgctgatt 3312241 aactccttgg cataataaaa aggaggatcc caatgagctc aagaaaagaa tgggcgctga 3312301 tcgtctcgct attattgggg gccattctgg ttcccattaa ctcaacgatg atcgcggtcg 3312361 cgctctcatc tatttcccat acgtataacg agtccatcgc aagcatcact tgggtggtta 3312421 ccgtttattt aatcgtgatg gcagtcacac agccgattgc aggaaagctc ggtgacatgt 3312481 acggcaataa aacaatgtac ttatggggag tcggcctttt tctaatcgca tctctaggct 3312541 gcgccctttc accgagtctg ctcctgttaa ttgtctttcg ggcattgcag gctgtcggcg 3312601 gggcattgct tacgccaaac agcattgcca ttatccggca tgttgtttct gaaaaacgcc 3312661 taccgaaagt gtttggattt ttcggactgg gcgcgggact tggtgcagca ctcgggcctt 3312721 ttatcggctc tatactgatt gacagcttca gctggcattc gattttttgg gtcaacatcc 3312781 cgttcctcgc cattgcttta tttacggcat taacgatgtt tcctcaatat aaagaaaata 3312841 aatctgacgc gccgctggat atcatcggct ctctcttgct tgcaggcagc atcgtttcca 3312901 ttatcctgct gacgaaaaat gaggctccat ggggatatac tgtatacagt gtattgatac 3312961 ttctttttgt tccgcttttt ttcagaagag aaaaacgtac ccagcacccc atcattgact 3313021 ttgcactgtt taaaagctca acctttacaa atgcgaatct atcagtcttg ttaagcaatt 3313081 tgatgatgta tgccgtctta ttgattatgc cgttatttat gacgaaccaa tttgggctta 3313141 atacatctaa cagcgggatg gcgctttctg tattttcgat cttcatgtca gccagcaact 3313201 gggtgggcgc gcagctccat cacaaatggg gagccaaaaa aatcattttt ctttcatttg 3313261 ccatgatggc tggtgcgaat ctattatttt tgctgttaag cagctcgcat tctgtcttgt 3313321 tcctcatgct ctctcttatc cttggcgggc tcgcttccgg agtcggtctg accagcatgc 3313381 aggtttcatc ccttgccaca gtagaccccg gtatgtcagg agtggcatct gggattttct 3313441 cgaccttccg ttatttcgga agcatcattt catcagcctt aattggcctg atttcgggat 3313501 atcacaccct atttatgatt ctctttgctg tatccatcat cggcgttttt gtttcattgg 3313561 gcatcaaatc tgatgaaacg gcacggatag aaaaaaactc agcgtaacac aaaacagccc 3313621 ggcatcgcat catcctgcgg tgccgggctg ccttttatga tcccgaagcg actgcttcgt 3313681 cttcacggtc atcctttacg aagaggatgc ccaattcatg atgttctcct tcataagaag 3313741 ctcgctggtc aaaacgaatt tctccattca aaccgataat ttcaagcttt acatatgcac 3313801 ggttatgctg aagcgcttca tagaaatcag aaacgttctt aaccggtatg ccattgactt 3313861 tcgttatgat ttccccgatt ttcaattcca gatcctcagc cggcgtattg gggataatcc 3313921 caagcaccat taagccctga tcccttttcg agaaataaaa cggagccgcg ttatcattca 3313981 ctctttgctt tatggacaga aaaatacgcc ctaacaaagc ggtacagacc gctgcacccg 3314041 caagcggcgt ccacagtaag ctcgctgcac cgagaactgc gacggcaaga ccgagaatac 3314101 aaacgcgttt cgctgtgatc cttatactcg tttcaggcag cgatccctgt accctttgtc 3314161 caaatccgac aaagtaagga atccatagaa aatggaatga gccgccggga accgtaaaca 3314221 cgggccacca gctaaggtgc gattctaaac cattaccggg cacgagaagg aacagcggca 3314281 aaagccaaac ccggtttgcc agctgctgtc cgatcggcaa accgcggctg cttacgacaa 3314341 gtgccggtga tgttctcaca tgcgcagaac gataagcaac cgctccttca gtgataatca 3314401 gcaaacctag aaacacagcc acagccggcc aaacaactgc aaatccttgc ggaaatctct 3314461 ccagaaaggg ctccgcctga tatatttgca gtccaaaacc tatcagcata ctcacactga 3314521 cgatatatgc agcagacatc cagtttgcgc gaagagtgaa cgctgccgct gcagtgataa 3314581 cggcaataat cgcaagtaaa ccgagaggaa tcgatattcc gagtccacct aaaataactg 3314641 acaaaagaag acctggaatc agtccctttg tatatgtaaa tttcagatca tcataaatat 3314701 ctgctattct tgtatgaaag gtttttcgtt cccgtttgat tcttacatag ccgaaagcca 3314761 aggttatgat gataaaaaac cagaaaagcg ggtgtaagaa gaacaagccc gcgcttttta 3314821 acagttcaat tccccattga acagacacta tctctcaccg cctcaagcca aacatgttac 3314881 tcatattcta tcaaatatta aatggcttgg atatcctcag gagagtttat ctctcttgcg 3314941 tcatccacag cgtgacattc gatagtgaaa aatcctttaa atagtggttt acatccacat 3315001 ccaataaccc gctgattaga tgcatcgacc tttttatatc tgtcagatta attcctaatc 3315061 gcttatggtt tttcattaag tagttaaaat aatgtttggc gcattcctca ttaatgtcat 3315121 ttactgattc gacattggtg taattgacca aatatctgct gaacagcata agaagactta 3315181 gtgcttttgt agctgaaaat gttacgtctt gtgttctgtc ttttaattgt tccactaatt 3315241 cataatattt ttttttcacg cacaatactt gccctcttca attgtgaacc cccattttct 3315301 ttatacagat aagcacgggc cagtataagc agcagtactg gagtgctaac aagcattctc 3315361 gctaacgtta ctctttaaat acctgtcgtt cagctgccat taacctgatt actgttcttt 3315421 ttagaacctt cttatattgt atgaagtaaa caaagactag gcaacttgca aaagtttcat 3315481 tttaaatgca tattaactcg ttagaaagtc tctctcatat attgatatcg ggtaataaca 3315541 gtcctttata aatgtttatt tgtgaaaatt tttttaattt cttgtcaaaa actcattttt 3315601 tatgtgactt atgatccata atctctttaa gcacaaagaa acaggagatg aaataccatc 3315661 tcctttaatt gacaaataat gatttcaatg ctgtttgaag ctgcaaatca tttttttcat 3315721 ctgatttttt cttttctatc tgctgattta atgtctctgc agtgcgagtg tcgatcacac 3315781 cggttttatt cagcttgttt tgatcctgaa aagccataac cgcttttttc atgtctttgc 3315841 tgaaatagcc atcctcacgt cccggatcaa agctgagacc ttttaacaat acctgcgcat 3315901 gcttgacgtc ttcattgttc atgtccactt taagcggctc tttcagctgt aagggcccgg 3315961 cggaaaaata atcgggctgc ttaatcgcaa tggtcggttc aattcctttc ttatgaatcc 3316021 agtttccatt tggcgtcagc cacttgtaaa gcgttaattt gatgttgctg ccgtccccca 3316081 ttggcacagc ctgttgaacc gttccctttc caaaagacgt atcgcctaca acatcataat 3316141 ggccagcttc ctttaatgcg ccggcaagaa tttctgatgc agaggcactt cctttatccg 3316201 taatcacatt gacagggtac gcttttttat gggtcaatgt tgaaaaataa cgttttttat 3316261 ctccattgcg ttcagcaatc tgaatatacg gctgatcctt tgtaacgaaa tgcttaagaa 3316321 tttcttccac actttgaaga tatccacccg ggttgccgcg tacatcaatg acaagtcctt 3316381 ctatttcttt tttctcaagc tccctcagcg cttttgcaaa atcctctgcg gtgtgctcag 3316441 aaaaagtaga gatggcaata tatccgacag aatgcccctg tacttttttc tctgatgcaa 3316501 aaaccgtttc gagcggaatc tcagctctct tgatccggaa tgacaactgc ttcttcgttc 3316561 caggccgctg aatcttcatt gaaacgctgg accctttttt tcctcttatt tttaacacag 3316621 cgtggtttaa atccttgccg gccatcgatt ctccattgat gctgataatt tcatcattag 3316681 gcttcaaccc ggctttttcc gctggcgatt tcttgaatgg agaaacaata ataattttgc 3316741 cgtcttccat tccaacctca gccccgatgc cttcaaatga ggaatcaaga gaatcagaaa 3316801 attgcttagc tgtctgcttg tccatgtaaa cagaataagg atcatttagc gtagacagca 3316861 ttccctggat ggctccctcg agcagctttt ctctatctac tttttctacg tactcattcg 3316921 aaattaactc atacgctttt tcgattttgt ccatagcttt atcccgttca gagtcagctt 3316981 gtgccgtcgc gggaactgct gcagtctggg gcttatccat ctcaagcagg ttgattcccg 3317041 catatacacc ggcgcctccg aacagcatgc tccctgctgc tatcacagcc attatttttt 3317101 gattcatcct ttactcctcc tgtatgccag actgtcttta ccaaaaccta gagatagtat 3317161 atgtaaagga tggagatttc atgtaatcat agaagaaaaa gaaggcaaat gaaaagccgt 3317221 cccgaaaacg gaacggcttt ttcactttat actcgcagaa acttgcggat ggaagtcaga 3317281 cttccccata ctccaattac tgcgccgatt gcaatcagca ctagcgaaac ttggaataca 3317341 aatggattat aaggaagaag agagacaaat gatccttgaa cctttggaac gacccatccg 3317401 atgacgtatt ggtaagtgct cagcaccagt gcaatcggaa tcacagaacc gaatacgcct 3317461 agcagcaatc cttcaaggaa aaacggccag cggataaacc agtttgtcgc gccgacaagc 3317521 ttcatgattt caatttcttt tcttcttgcg aaaattgtaa ttttaatggt gttggaaatt 3317581 aagaacatcg ccgtaaatac caggccgata attaacgcga ttccgatgtt gcgggaaacg 3317641 ccgaccactt taaacaaacg gctgacctct tcttttccat aagtgacttt ataaacatga 3317701 tccatttttt cgatcttttt cgccacgttc ggcgtatcat gcggatctgt cgttttgacg 3317761 acaaacgcat cattaagcgg gttttcctga tccttcattg tcagggattt tccgctgtca 3317821 ccaaaactgt caaccagctg gtcaagctct ttttctttag atgaaaaagt gacactctga 3317881 atgcccttca gttccttaat atcgttctga agcttgtcct gtgccttctg atctgcagtc 3317941 agatcaatca gcactttgat ttcgacttgt ttttctgcat tcgtggccat gttattcaaa 3318001 ttcagcataa tcactaaaaa cacgccgact aaaatcagcg taacggttac agcactaatg 3318061 gatgcaaatg tcatccatgt gtttctcccg agagatttaa aactctcacg caagtggcgc 3318121 ccgagaattt taatcatatg aaccatactc ccctcttgac tcatcacgca caatgatacc 3318181 atcttcgatt gcaatgacac gtttcttcat ggtgtttacg atttctttat tatgtgtcgc 3318241 catcacgact gttgtcccgc ggttgttaat ttcctccagc gtcttcatga cttcccagga 3318301 cgtatccgga tcaaggtttc ctgtcggttc atcagcaatg acaacatcag ggttgttcac 3318361 aattgatctg gcaatagata cacgctgctg ctccccgcct gaaagctggt caggaaattg 3318421 tcgcgcttta tgcttcagct gcacgagatc aagcacttca agcacccgtt tcttaatgac 3318481 agacggctgt tctccaatca cttcaagggc aaatgccaca ttttcaaaaa cagtaagttt 3318541 cggaagaagc ttgaaatcct gaaagacaac acctattttg cggcgcacga aaggaatctc 3318601 tttttcttta attgtcgcga gatctttatg attgattaaa atttgtcctt ttgtcggttt 3318661 ttcttctctg taaatcattt taataaaagt agatttacct gctccgctcg gaccaacaac 3318721 atacacaaac tcgccgggat gaatggtaac agaaatccca ttgagtgctt ttacgccgtt 3318781 cggataggct ttatatactt ccttcatctc tatcatgaaa tcacctaatc ttttatatca 3318841 ttttatctat cacacggtca tactcttcga atgcattcga caatttatga cccattcatt 3318901 tgtaaaaaga tgaaaaatct gaaagttccc tttttcaata cacttcatta tacgtcaaat 3318961 ttagacataa tactattaca gtttcttttc attcatattg tcaaggcata aaaacatcct 3319021 tgccagcact cggcaaggat gtttttatct tacttttttt ctgacagcca tttggcaata 3319081 acagcggctt cgttatcatc tacaagcccc tttggcatat tgccgcggcc gtttttaata 3319141 atgctttcaa ttttgtgttc atcgtatttg cctccgacct cttggagatt aggccctgac 3319201 acaccttcta aatccttgcc gtggcagcct acgcagcttt gctgatataa ttcttcccct 3319261 tcagatgcag tggcttccgt cttgctgcca gtgtctgtct tctcttcttt tgcatcgttt 3319321 gatccgcagg cagccaacag aacagaaagc gcaaatccaa tcattagtat cgataacttt 3319381 gatttcatgt tgagaagcac aactccttta cgatctcttc catattataa cctcgtttaa 3319441 gcgcgtttga aaccctcgcc cagcacctcg ctcgcgtctg ctacaattac aaaagctgac 3319501 tcatcaatct gtttgacgat ttgtttcaat ttggtgaatt cagtttgccc aaccacgcac 3319561 attaaaatcg gacggtcatc gtcagtatat ccgccgactg cagaaatttt tgtcacgcct 3319621 ctgtcaatct tctgtaagac agcctccttg acagcctgct cctgctttgt aatgatgagc 3319681 gccatttttg aacgattaaa gccgacttgc acaacatcaa tggttttgct ggacacatag 3319741 acgccaagca tggcatataa gccttgctca atattaaata caatcatagc cgtaacaacg 3319801 atcattccgt caatgatggc gagacacttc cccaatgaca gaccggagta cttatgaatg 3319861 atctgtgcag ccaaggctgt acctcccgtc gaacctttcc ctaagtacac aataccaatt 3319921 ccgataccta tcccgacacc gccaaaaatc gccgccagga gttcatgatg agtggcgggc 3319981 tgaatatccc ttgtcagaaa cactactagc ggcaaaaaca cagaacctgc aagcgtcttt 3320041 agtccaaatt tcccgccgag caaaatgacg ccagcaataa ataaagggat attaataatc 3320101 cactgtacat acgctgcttc aaaaccatat gattgtaaaa tcgtactgat cccgctgacc 3320161 ccgccggcgg caatcttatt cggaagcaaa aatacattaa aggacacggc cgtaatcgct 3320221 gctcctatca atatgtatac ataatcccgc aaaatccaca atgttttatt ccgtacgtcc 3320281 atcatatatc ctccgtttct tccaatgctc tccgatagca ttttaatcct tccctgatta 3320341 gatgtaaata acacccaaat acagtggtaa tatgctaaag cagcagtgaa atcaaggata 3320401 taagaaataa aaaaacacac ccgtatgcat caggtgtgtt tttcagctta tgaaagctta 3320461 gaacgcaggt aggcatcaat aaacgtatca atgtcaccat ccattacagc ttgaacgttc 3320521 cccatttctg tattggtccg atggtctttt accatggaat acggatggaa tacataagaa 3320581 cggatttggc tgccccagcc gatttctttt tgttcaccgc gaatttcatc cagctctgcc 3320641 tgctgctctt caattctgcg ctgatacagc ttggccttca gcattttcat ggctctttca 3320701 cggtttttaa tttgtgagcg ctccgtttgg catgtcacaa ctacgttcgt cggcaagtga 3320761 gtaatccgaa cggctgaatc cgtcgtattg acgtgctgtc cgcccgcgcc gcttgcacgg 3320821 tacgtgtcaa ctttaatatc ctccgtacga atatcaatat caatttcatc gttaaattca 3320881 ggcatgactt cacatgaaac gaaagatgtg tggcggcggc ctgatgaatc aaatggtgag 3320941 atccgcacaa gacgatgaac acctttttct gctttgagat acccgtaagc gttgtgtcct 3321001 ttgatgagca atgtcactga cttgattccc gcctcgtcac ctggaaggta atcgagagtc 3321061 tctactttaa agccgcggcg ctctccccat cttgtataca ttctaagaag catagagccc 3321121 cagtcctgtg actctgtacc gccagcacca gggtgcagtt ctaaaatcgc gttattttta 3321181 tcatacggct cgctgagaag aagctgaagc tcaaactcat tgaactcttt tgttaatgac 3321241 tttagttctt tttcaagctc aagctggaga tcagtgtccg gctcttcttt caaaagatca 3321301 tgagtcattt gtaattcttc gtgggattca ttcaattttt tatacgaatt gacataatcc 3321361 tttaaaccgt ttgcttcatt tataaccgtt tgagcttttt gctgatcatt ccagaattcc 3321421 ggatcagcca tttgttcatc tagctcagca atgcgggcct cctttgattc gaggtcaaag 3321481 agacccccta aagtccgcta aacgagaagc catattttcg agctctgctc taatttctga 3321541 taattccatt tcattcacct cattaaaaga tccgcaggcg cctgcaggcg ccgcggtcag 3321601 taaacttgcc ggggcgaact attcagtacg gccgcagcaa tttttatatt ttttcccgct 3321661 tccgcagtgg catggggcat ttcgtccgat atcaaccact ttgcgaaccg gtgctttctt 3321721 tgcttttttg ttatcgtcgc cttcttgcgg ctgatgagct gttgtttgac cttgtacaac 3321781 ctcttcacgc tccagattgt tttcaatctc agctttcatc acaaattttg cgacttcgtc 3321841 ctcaattgat tcaatcatat gctcaaacat cgcaaaacct tccatttgat actcacgaag 3321901 cgggttcgtc tgcgcgtaag cacgaaggtg aatcccttgg cggagctgat ccatcgcatc 3321961 aatatgatcc atccatttag aatcaacggc acgaagaacg ataacttttt cgaattcgcg 3322021 catttgctct ttgccgaatt gctcttcctt ctcattatat tttgtgatga tgcgatccat 3322081 aatgagctca agcatttcat ccggttcttt gccgaagata tcgctcttct caagtgcacc 3322141 ttcatcaaga taagttgtgt tgataagatc aactagaccg tcaagcttcc actcctcagg 3322201 aagctcttct cttggcgtat aggctgcaat tgcgcgttcg agagaagact tgatcatatt 3322261 ttcaacgatt tcacgcaggt tttcagagtc aatgacttca aagcgctgct tataaatgac 3322321 ctcacgctgc tggcggagaa catcatcata ttgcagaagc tgtttacgcg aatcgaagtt 3322381 attgccttcg acgcgttttt gagacgattc aaccgcgcga gataccattt tgctttggat 3322441 tggagtagag tcgtccatgc cgaagcggtc aagcatcgcc attgtccgct cagctccgaa 3322501 tctgcgcatc aattcatctt ccatagaaag ataaaattga gtaatccccg ggtctccctg 3322561 acgtccggaa cgacctcgaa gctgattgtc aatccggcgt gattcatgtc gttctgttcc 3322621 gactacagcg agcccgccaa gctcttttac accttcgcca agcttaatgt ccgttccgcg 3322681 ccccgccatg ttagtcgcaa tcgtaactgc gcctttttgg ccggcctctt caatgatctg 3322741 cgcttcacgt tcatggtttt tggcatttaa cacttgatgc ggaattcctt tgtttttaag 3322801 cagcttagaa atcaattcag atgtttcaac ggcaaccgta ccgactagaa caggctgtcc 3322861 cgtcatgtaa cgctgtgcga catcctccgc aactgcctta aactttcctt ccatcgtgcg 3322921 gtaaattaaa tccgggcggt catcacggac aacaggcctg ttggtaggga tcgtgacaac 3322981 ctgcatgttg tagatgttgc ggaattcttc ttcctctgtc ttagctgtac ccgtcatacc 3323041 ggcaagtttt tcgtacattc ggaagtagtt ttggaacgta atcgtcgcca aggtcatgct 3323101 ttcgttttga atctcaagcc cttcctttgc ttcaatcgct tggtgaagcc cctcactgta 3323161 gcggcggcct ttcatcagac gtcccgtgaa ggaatcaaca ataacaacct gtccgtcttc 3323221 cactacatag tcaacgtcct tttgcatcgc aacgtgagct tttaaggcct ggttgatatg 3323281 gtggttgagc gcgacatgct tcacatcaaa gaggttatcg atgccgaatg ctttttccgc 3323341 cttcgtcatt ccttcttcag taagctgtac agcttttgtt ttgatatcgt acgtgtaatc 3323401 cttctccgct tttaacgtgc ggacaaaagc atttgcctgt acgtacagct tagtggattt 3323461 tgcagcttgt ccagaaatga taagcggtgt tcttgcttca tcaattaaaa tagagtcaac 3323521 ttcatctatt accgcaaaat gaagcgggcg ctgaaccatc tgctctttat aaagaaccat 3323581 attgtcacgc aaatagtcga agccaagctc gttgtttgtg gagtaagtaa tatcagcggc 3323641 ataagcttcc cgtttttcgt cttttgacat tgagtttaaa ttcaaaccga cagtcaaacc 3323701 gagaaactcg aaaattttcc ccatttgctc agcgtcacgg cttgccaagt attcgttgac 3323761 agtcacgacg tgtacgcctt taccggttaa cgcatttaaa taaacaggca gggtagacgt 3323821 taatgttttc ccttcccctg ttttcatttc cgctatattt ccgtcatgaa gcgccacgcc 3323881 ccccatgagc tggactttaa acggaaacat gcctgttacg cggcgtgaag cttctcgaac 3323941 aacagcgaaa gcttcaacaa gaagatcatc cgttgtcgcc cctttttcaa gacgctcttt 3324001 aaattcaatt gttttatgtt tcaatgcgtc gtcagagaga ttttcatagt ctccgcgaat 3324061 cgcatcaata tcgttagcaa ttttttcgta tctattcagc gtacgttttg ttggatcaaa 3324121 cattttattt aaaattccaa gcatttataa cgctcctcta tcatcacacg cctattttag 3324181 aggcatgtat aaataattta ctagtccatg tatacctctc attatcatat catacctttt 3324241 gttatttcca aagaatttgc aaataagaaa aacaaaaacc ttccgcggac atcacggaag 3324301 gcttctcttc attattcagt cggttcaatt aagccatatt tcccgtcatt tctgcggtac 3324361 acgacatttg taaggtttgt ttccgcattt gtgaaaacaa agaaattatg gccgagcata 3324421 ttcatttgca agatcgcttc ttcactatcc atcggcttta aattaaagcg tttctgacgg 3324481 acgatgtcca agctctcctc ctcttctatg tcatcctgaa ccgcaatatc tgtatcagag 3324541 ccaagaccgt ttgccaataa atattttgga gagccctgct cacggaattt acggtttact 3324601 ttcgttttat gcttacggat ttgacgttcc agtttgtttg ttgcgagatc aattgcgttg 3324661 tacatatcct cgttatgcac ctcggaccga agcgccagat ctgtcatcgg aatcgtaacc 3324721 tcaaccttag actccttgtc attgtaaaac ttcaagttga cgttcacatc agcatccacg 3324781 ctatggtcaa aatagcgctc cagcttgccg atcttcctct cgacatgatc ctttaacgcg 3324841 ggtgtcactt caatattttc tcctctgatg ttatagttca tcaaagaacg cctccctttt 3324901 attaaggata tgtatctatt tctcttttac cctttacaat tcctgctgaa acataaatct 3324961 tttgtgaaaa ttcagtgaac tttgtcgaat tttgtttgta tttgctctgt tattggcggt 3325021 tcggaggtat atgtatatgc tgattgaacg aaacaaatac ctcacacacg cctaattgat 3325081 taaaaagggt tccatacatt gatgaataga cagcatccat tttctataat gaatcagaaa 3325141 atgttccttt aaatactcac agaactcatg agagggaaaa gagaaagaga ccaattgatc 3325201 aaactccgca aaaatttggt caaatgcttt cacacaaatt tcagcacacc gcgaatccat 3325261 aatgaagaga agtgttgaat gtgttgaatc caaataaaaa aaggcttgga tcagatcttg 3325321 gtagatccga tccccttctg tttttgataa attctcttca gcctctatca aataacacaa 3325381 cccctcttcg atggtaaaaa gaagatgata ataagctgat aaaagcgtat aatcttcaat 3325441 gctcttcaag gcactcacct atttacgctt gtcataatat gtgccgtcaa tcgtaatgtt 3325501 gttataaggg tttaaatacg tcgtatgcat cacacgtttt cttttcatct gctgaagttc 3325561 tgttgcgatt gactgcttca gtctttccat ttccttcaca atcagctgat cccatgtcaa 3325621 aataagtttc atctgctttc gctcttcttc tgaaagcggc agagatatct cctgaatcag 3325681 ttcagaccgt gtagccacaa agtcttcaat ttgctttaaa agttcatcgc tttccggcgt 3325741 attttgtatg tgtgacagca tactcttcgt ctcagtgtat agttgatcta tattattcat 3325801 gcgatcccgc ctgatccgtg ccggtccttc cgctcacttt gaatggcttg tttccaagca 3325861 tcgcgaaaat ctgttacata accttcaacc tcagccagca tgcccgtatc atttttgata 3325921 tttgcctgta ccaatctgcg atacatataa tcgtacatcg cacccataga agcggaaagc 3325981 tctatgttac ggttaagtgt aaaatttaat tcctgaataa tattttgcgc tttaatcaga 3326041 ttttcatttt tacgttccat atcatcattc tcaatggcct gagcggcaag tcttataaat 3326101 ttcaaacagc cattatacag cataagcgtc agctccccgg gtgtagccgt attcactgaa 3326161 ttttgctgat aggctgtata tggattttgg atcgccatgt gtcatcctcc aaattacatt 3326221 tattgtacaa gaagctgtga taaataggac gcttgttcgt tcattttttg aatcgcagaa 3326281 tccattgcac tgaattttga ataatagcgg ttttctatgg tattcaatct gtcctgcata 3326341 tcagttattt cagtacttat cgagtttaaa ttttttccaa tggaatagct actagctccc 3326401 attgtcgagt tcccagcttt agcttcaata cttttcacag tacttctaag tgtattagta 3326461 atccgcttca taataccttt atcgctatag ttactatcat ttgttccact tgtaaaaaga 3326521 ttagcaactc cttgaggatc ttctgctatt tttgctttca atttctcttc gttaatctct 3326581 aagtgccctc gcagttggta agcacttgaa gttgtgatgc caaattcagt taattgatag 3326641 gttttcccat ccgcattcac ttgagtataa aagtcagtcc gcatttggtt cgtgccagtg 3326701 ctgatgcttg aatcgtttct cagcaatccg cttttcgcct tctcctccca gagctctacc 3326761 tctttatcgg acatggcttc tttttgttca ctcgtgagtg gcgtatagtc tcggtatttt 3326821 tcttctttca gcttttcatt caggctgtca accagttcat tgtatttatc tacaaactct 3326881 ttgatttggt tataaatccc atcaacatca gtagaaacag atgtggtaac agggcctgtg 3326941 gctgcagttg tatttttaat cgaataagta acaccattca ccgtgaaatt gtttgtcagc 3327001 ttctccattt caaagccgtt gattgtgact ttggcatttg tgccttcttt gtaagcagta 3327061 agcttattat cagcatccaa agaaaaacca agctgaccgg acataaagtc agctgtagca 3327121 gagtctgctg cctgtatgct tcctcctgca cctgttgctt tagaagaaaa cgcaatcgtt 3327181 tctacgtact ctgtaccatt ccaaatttta tctttaaatg ctgatactcc tagatctgag 3327241 ctgttaagtt tagaaatcac attatcaatc gtatcggcac tcgtcacact aatgttcact 3327301 gtttttgctg ttgtttcgcc aggcgcaaca acgttaaatg ccaaattgta atcgccttgt 3327361 gtgtatcccg tataattgtt tgccttatac gttgctgcag ttgccaagct cgccacttca 3327421 acagtagacg aagaatttgg cgcacttacg cttcctgtag cagttaacac agactcatta 3327481 gagcttgtca cagttttgct ctgatacgtg ctcggatatg tcaacgtatt tttagacata 3327541 taatcttgca attcttttat ttttgagttt acttcacgat agctgtcacg ctgccattca 3327601 agagtctgct ttttttgtgt cagcttatca agcggcgctc tttctgtctg catcagcttt 3327661 gatacgatat catctatatc cattcctgac gccagacctg ttattcttgt gaccatctca 3327721 aaccactcct attctacttt ttttcatcta caaataaccc aagaaattca gtcatagccg 3327781 cataaaaatc aagccaccgt tttggtggaa tttcgcggat cacttcattt gtagagtcct 3327841 ctattacctt tacatagtat tcatttaact tgtcatgaag ctcgaacttc agatgaactt 3327901 gcgaaggttc caaaagcttg ttcatttccc ccaccatttc agcaagattg gtatatgaaa 3327961 cttgatgaac aggaacctcg ttatcattat ctttctgatt atgtatttga gtatcataac 3328021 gatcccaaac aggttgtaac gtagtgagcc tttcaatgtt caattgatca tcccctatgc 3328081 cccaatctat cgtttatatc gactaagtcg agataagatt acacatattt ttggaaaaaa 3328141 atcttctgtt ttagatttct tgtatggaaa tacatttata aaaagttagt ggagaatccg 3328201 gttattatat catgagttag tgacaggatg aggaatgatt aggagataga aatttaaatt 3328261 aaaagaccct ggcaacgcca aggtcttttt taaaattaac gtaataattg aagtacgttt 3328321 tgcggctgtt ggtttgcttg agcaagcata gcttgagaag cctgagaaag aatgttgttc 3328381 tttgtgaatt cgctcatctc tttagccatg tcaacgtcac ggatacgaga ctcagcagct 3328441 gtcaagtttt caccagaagc gcttaagttg ttaattgtgt gctctagacg attttgtacc 3328501 gcaccaagct tagcacgttg agaagaaact tggttgatcg cttcatcaac aactttcaat 3328561 tgagcatcga aaccgatatc agcagtatct gctgcattat ctgcgaattt tgttacgtca 3328621 agatcattaa ctgaatgaag agctgcaatt gaaccatcag cttctttaat tccaagagcg 3328681 tcagcaccca tatcctcaat atttacagag atttgctgtg tagcatttgc tccgatttgg 3328741 aataccaagt tcttttgatt tgcaggagta gctgtgtcaa ctttgtaagt gccatcgagc 3328801 aatttcttac cattgaattc tgtacgattt gaaataccat cgatttcatc tgttaaagct 3328861 gaaatttcat cttgaataga ttgcaaatca gttgctttgt cctgagttcc agtgtttcca 3328921 gcttgaacaa ctagctcacg aacacgttga aggatcgcat gagtttcagt taatgcaccc 3328981 tcagctgttt ggataagaga gattccgtct tgagagtttt tagaagccat ttcaagacct 3329041 ctgatttgtc ctctcatttt ttcagagatc gcaagacctg ctgcgtcatc tcccgcacgg 3329101 ttgatgcgaa gacctgaaga aagtttctcc atgttctttt ggctcgcact gttgtttgaa 3329161 gacaaacggt tcagtgtgtt aagcgctgca atattgtggt taattctcat tgttttgttc 3329221 ctccctgaat atgttgttaa ggcacgtcct tgtgccctta ttttgtaact ggctgagtct 3329281 tttgcgcctc ctcccggcta catcattaat atcggattgt ctctgatttt gttaatacaa 3329341 aaataaaaaa atcctcactt tttttgtgag gataatgcgg agatcacatc gctggataac 3329401 gctgctgcac ggttattttc ttcctgaatg gtcaagtaaa tttctttcct gtgaatatca 3329461 atatgctttg gggcgtcaat tccaagcttc acttgatccc cttcaaccgc aatcactttt 3329521 acttcaatat cagcacctat ttgaatcgct tcgtttattt tccgcgataa aactagcatg 3329581 attctcctcc aatcggatgc tttgtcgtat atgaggagtc gtgtaaaacg acttgcttag 3329641 ccatcatgtt cttgcgattc acaataatgg gagccaataa attcgcagta gacttttcaa 3329701 atggctctgc catagtcaat attgtcatga cttctacgtc ttgaatatta tcgatatcca 3329761 aaagttcagc agttgattca tcaagatcaa attcataatt cttaaaaaag ataaacggac 3329821 ttacgacgat aaacgcaaga ttttctgaag tgacggactg cagtgccacg aatggagagt 3329881 cttctgaaag cggaagtatg acgaactgtt tttcttctaa aaagcctgga atcccgcttt 3329941 caaaaagaat gatttgttct tcttttatgt tcatttggcc atggtacttc gtatgaatga 3330001 tcattgttca cgatcctttt ctttttactt ttcgggtgat tctttcgggt attctacatc 3330061 tatatttaaa tcagggtatt gaagcatgtc aaccttaaca tttcctggcg tatattcaac 3330121 aattggctta tgcggctcag cctgaataac aggctttcgc ggcgtaatct gcacatcaag 3330181 ctgtgacgga gtatattgta ttttcaccct cgaaagagaa ggagcataat tttcgcctaa 3330241 ttgaatttgg tgcatttcag agttcctcct tgcttgtgaa gcgattgggt tccccttatt 3330301 ttcaatcttc ataagctcgt cgccttcttc tgcagtgcgt gctattccct ccattacatc 3330361 ctcatgccct tgttgggcgg cttcttcaat tctcttgaaa acatgctttc tgtctaattc 3330421 ttcccatgct tgtgtctggt caatcgtgag ttttccaggt gtcaccgata tttccatttc 3330481 cgcactcggc tgttcgatct ctagatcagc ttgaggctgc tccattttta agctggcagg 3330541 cgtcgttgtt aaaccaattt ttccttgaac actatgcata atcaatctgg gaatctgcat 3330601 cactctacct cctgaactat aaaaaaagcg aactcctaag agccgcttac tttaaaaagt 3330661 caatcaatgt aggctgaaca atttgcgcat taacggccag agtagccctg tgcacacttt 3330721 gctgcgcaat aaattcagtt attacttctt ccagttctac atcttcattg tctgataaca 3330781 ctttggtagc tgtttcttct tgcgctgaca gtcttgtatt aaccagttca agacgattat 3330841 atctcgctcc aagatcagat cgttcagcgc tcatgccgtc agaaaaatga tcaatatcat 3330901 ttaaaacact gtccatgcca tctagcgaac cagaatttag tgctttctca aaagaatcaa 3330961 gcatttcaaa tacattctgc ccgctttcag aagtgcctcc aaaagctgac tttggatctg 3331021 aattcacttt caatgacata ttatttgata tattgactac gacatcagct gtatcagaaa 3331081 ttgtataagt tccgtctccg ttatctgtaa ccggaggctt atctgaattt gtgccattaa 3331141 agatatatct gccgttcact tgtgtattcg caatatttaa aagctgttcc tttaactgct 3331201 ttacctctac gccaatcgct tgccgctccg gctcgccgtt tgtatcattt tgagcttcaa 3331261 ccgctaattc tctgaccttt gacaagatgt caattccttc tgtaatgttt gtttctgtgt 3331321 tttcgagcca ggtaaaggct tgagaagcat tgcttttgta ctgctgcact tgagacagtt 3331381 gcgtattata ctttaagctt ttcattgcta ctacaggatc gtcggaagct tttgagattt 3331441 tttttcctga agaaatctgc gactggagtt tatccagctt cgagtagctt gaaccgatat 3331501 atctcagtga gttttgctgt atcatgcctt gtgttactct catgtgactc tacctacctt 3331561 cctccaacac ccatgccgtt gatcacttta tcaagcaatt cgtcttgtaa agtcaccatt 3331621 cttgcagctg cattgtatgc gtgttggaat tgaatcatat tcgtcatttc ttcgtctaaa 3331681 gaaactgcgc tcatttgctg acggtttatg tcagcatcat tcagctgtgt ttctgtatta 3331741 gacgccagtc gattagcctc ttgagcttcg atccctagct cgccaatcag acccgcataa 3331801 taatctaaaa cactagtttc tttaccgtta atggttattt taccggttaa aacatttgct 3331861 aattttgtag catttgcgtt atcgttggct gcgccagtca gtgagaaagc aatgtttgcg 3331921 ccttttgaat ctattatgct gtcagccact ttgatcttgc ccgccgcgcc cttggcaggt 3331981 tcagtttcac cgccagtaaa atcaaaaaag tctccgcctt gttcaccgct cttggtcaca 3332041 ccatttctgt gcacttcatt gaaagctttc gcgaattcaa gcgccatatt gtcaagatca 3332101 gaaagcattt ccgggtatac gcccttttct tggccatctg ctgttatata cccataagac 3332161 tctataaacc ctaaaaggga tcccttgctg ctaaaggact ccgcctgtac agctgtatcc 3332221 ccgattgaaa tacttgatac taacccagtt tcattatcat agttggctgc aagttctgaa 3332281 acctcgtaat ttttaccgtc caaaacagtt cctagcgact gtttattttt atcaaggatt 3332341 tcaattgata cagttccttc agcagatgca agtgcattcc cgcctgattt gttgtagctg 3332401 actttgatat caaccattga ggataattta tcgatcagca aatctcgctg gtcatataag 3332461 ccattcggaa gaagcccgac cggctctact tgtgcaattt gcttatttaa actgtttaac 3332521 tgagaaagca gagaattgac atccaacaca gttgtattta gctctgcttt taaattcgat 3332581 tggacatttg taagtgattc agaaatataa ttaaacgttt cagctacagc ttgtcctttt 3332641 cgagcaacaa cagaacgtgc actttcttca tttgtattat tcgataattc ctgcagggaa 3332701 ttccaaaacg aattgagcac actgttcaag ccgctgtcat ccgtttcatt taaaacgcct 3332761 tccatttggg acagcgcttt tgccttcgtg tcatagtatc cggcactgtt gttttgaaga 3332821 cggtattggt agtcaagaaa gatatctctt attctctcaa ctgattttcc ttgaacgccc 3332881 gtacccattt gtcccgctgt tttttctgca tttttagata cagcagggaa atagtcagtt 3332941 gcctccaatg agacccgctg tcttgtataa ccatcagtat tggcatttgc cacgttattt 3333001 gcagtagtgc ttaacgctgc ctgctgagcg cttaacgccc gccttgcagt ttcaagcccc 3333061 ataaaggtag atgtcatttt ctgaattcct ttctgctaag cttttgaatc aaacagtttc 3333121 attttgctac ttttcggcag ctcagcttta attgatttgc tgtaattgaa gttattttcc 3333181 ttaggaacca gcatatcgta cgaaatagag atgaattgca gcgcgtctct tgtcagctgc 3333241 ctattcatct catttacttt tttcagacgt ccgagaactt gagaaagaga ttcgtatagt 3333301 tgttccagct cttccttttc actgcctgag gttttggcga tacatgcgga aatagtatta 3333361 ttttcgctat atccgagaaa ggccgaagtt gttttgatcc ggtcatcttc tgtctgcgtg 3333421 attgcttgaa tatatttttg ctcttttgtc aaaatgttag aaagctcttt tgttttgccg 3333481 gctttgagcg cttccgtctt ttcttcagac agcgtgagca ggtgctcatg cagaacgcaa 3333541 agtcgcttca attgttcaat aattgccttc gctgacatgg gctttctcct tttttattgc 3333601 tttttataaa aattaatcat atttttcgca atatgatttg cgtctacttt gtatgacccg 3333661 ttttcaattt gcgctttaag ctgcgcaatt ttttcctgtc gtgaaccagt gactgcgtcg 3333721 gatgcatgtt gcatttcttt agcctgtgat gaaatttcaa ttttatcttg aggttgtgca 3333781 acagtttttt gcaccgcttg cttatcataa tttttttgat atggattaac ggattgtgtt 3333841 ccaaattgat tgattttcat aggattcctc tcgctttccg ttgcagtctt taaacaatct 3333901 taaccctttt atcgactgcg ttttcagtta gtttagggaa tcagctgttt ttggtattat 3333961 aggcatagta tgtgtctttt ttactatttt ctttctcgat tttcagagca tcctcgtggt 3334021 tcaaatgatc catttgatcc ttaatatcag actggcaagc cttgcagaac ttgccttctc 3334081 taatcgatgt cccgcacctt tcacaagggt atgccaaatt aggaagatga gtgatctgaa 3334141 ttcgcttctg cctgatgaat ttcaatatca gctcttcttc cacacctgtt tcctcagtta 3334201 tccggctcaa agttgattgc cggttttcct gttttcttaa aaatttatag acagtctcaa 3334261 atgatttttc ttcttcctta atacacgcct gacatacggt ttgcagcttt gtttttaaaa 3334321 ataaagcatt gcatttcgga caattagcca gttctcccat ctttttttct ccttattaga 3334381 taatatgcct gtgtcaattt ctagtgatta tatcggcata aaaacagaat catttagctt 3334441 ctgatcaagg taaaagatga cactgaagcg gcttttcctt tttctaataa gcagcgggct 3334501 gcgaagtgca aggtggcgcc tgttgtataa agatcgtcta ttaaaatgat attcatacct 3334561 tctgctgaat tattttttgt atcaaaaatg cactctgaca gcaggcgttc tgttttcttt 3334621 ttctttgact gtttctcatt attcaggcga atgaggggat ggtgggaagg ccggtctaaa 3334681 cattctgcca agagatgtgc ctggttaaat ccgcgctctt cttcccgttc cttgctcagc 3334741 ggaataggta caagaacaaa atgcttatcg gggtaaacct tagaaaaggt tgaagaaaaa 3334801 tcacttttaa atgcatttat gatttctgca tctcctctaa atttaaaacg ggagagcgtt 3334861 tctttcatca tatcattata tgtgtaaact gaacggtttt gacgcaatag caaactgtct 3334921 ctgatccttg ttctccacac ctcgcaatcc ctgcatacgg catgaacaga ttgaggtctg 3334981 ccgcacaggg ggcagatatg tcctgtgatt ttctttaatt tgcttctgca agaataacaa 3335041 accttttcat caggctttag taaaaaaagg gctctccatg taacatcttg agaaaattgc 3335101 gaatcacata ataaacagat cagtttatga atgcctcctc ctgcttcgtt tgacataaat 3335161 cgcttggact ctctgaaact actgcagcag attcagccaa aatgacaagc attgctgtgt 3335221 ttttttgttt atctaccagc tcagctttcg tatatgcgat ctttttaaaa tcagtaacgt 3335281 aggatggact cactttgttt aaagaaagtg ccaatacatc gttttggcat acttggcaag 3335341 tacaggccat atgaagctgg tccatatatc ggtcgagcag ttctttcatt acgatttctt 3335401 ttgaattgac aagcattttt acagctcctc atcatcggtt atatgagtat actgtaccac 3335461 gttttcaaat aatggctagt ctgtacattc aacttttgct gccaattcat tcatttcttt 3335521 tatatgcttt cttgcatcga gcatactctt tgttttgccg aagtgaaagt aaatgacatc 3335581 gccgtccgca tattctttat gccggccggt tcttcctgca atttgaacaa gtgcgctttc 3335641 cgtaaagata gacgattccg ctcctagtac acccgtttgc accttgggga ctgtgacgcc 3335701 tctttccagt attgttgttg tgattaatag atcgagctga ccatctctga attgctgcac 3335761 tttctccttt ctatgcttgt cttccgcgtg cacagatgcg gttcggcaat gaacaccttt 3335821 aaagcacgca gcagcctttt ccagaataga aacggaagga acgaataaaa aaacaggcct 3335881 cccttctttt acatgaaact ctatccatct tttcaccgct ggcggaattt tatttcggtt 3335941 taatttcttc ttccagtttc cacaccatac aaagcgcggt tcgggtaaag gtttccggtg 3336001 gtgtcttgcg gggatgcgaa ctgaatgtaa ctgtccgttc agtgcttttc tttttaattc 3336061 tttaggaggt gttgcactta aataaacgag ggtgctgttt ttctttcttg ctttttgaac 3336121 agcgaattga agggtttgat cagcagaata tggaaaagcg tcaacttcat caatgatcat 3336181 aacatcgatt gcatctttat atcgcaaaag ctgatgcgta gtggaaatca taagcggaga 3336241 tagccgccct ttgtcatcgc ttcctccgta aagcgctgaa atgtcagcac cctgaaaggc 3336301 agccttgagt cttggagcaa gctctaatac aacatcggtg cgaggtgttg caatacatac 3336361 acgcagtcct tgatttaacg ctgattctat accaggaaac agcatttctg ttttgccagc 3336421 gccgcaaacc gcccagatga ggagctcttc tttttttgat attgcttcaa ttaaaacatt 3336481 ggcggctttt tgctgtccgc ttgaaagctt gccatcccat gtcagcttaa tagacttcca 3336541 gtttgattca ttttcctctt tccatgaata taaaggaacc tcctcactca ctctgcccat 3336601 catgacacag gaacggcaat acagcttatt ctttccagat gagtgataaa aagaaaaata 3336661 ccgctgatca gtttgtccgc acctattaca tctatatctc cgtttattta tggatataga 3336721 attttcagca gtgatatatc cattcttgat atgccattca atcatctcat cggaaaatga 3336781 gagctcagtc ctgagcaaat gacggcttcg aagcgtctgc tgcaattctt ttgaaaagga 3336841 actgtttttt tcaactggca cattcacata gcacgcctcc tttcgaaaca gtatgcctga 3336901 atgaatattt tctgtccaac tattaaaata agaatataaa aaaatctccg ctctaaaaac 3336961 ggagatttgg ccttatttaa aacaccagca aattcctaac gcaccttcac ccaaatgagt 3337021 gccgattacc gcgccaaaat agctgttata aaattcaaca tgaggatatt ttgcagaaag 3337081 ctcttcaatg attttcgctg cttcttcctc tcgattagcg tggataacag cagctcgcat 3337141 aggcaaccct ttactcgcat cttcgtctaa aagctcataa attcgcgaaa ttgctttttt 3337201 acgtgtgcga atcttctcaa aaggcacaat taccttattg tcaaaatgaa ggataggctt 3337261 tacctttaga agactaccaa tgaaggcttg ggcgctgctt aatcgcccgc cgcgctgaag 3337321 atgggctaag tcatctacca taaaataagc tcgaactgtt tttttcattt cttccagttc 3337381 ttttataata tcttccggcg atgatgctcc gtttttgatt aattcagcag ctttaagggc 3337441 ataaaagcct tgagccaagc agctgatctc tgagtcaaat ggatacacat caatattgtc 3337501 gaccatcgaa tcagccgctg ctgcactgct gaatgttccg ctgatcccgc tggaaagatg 3337561 gatactgata accgcatcat aagacttgcc aagctcttca tacaacgcaa ccagctcgcc 3337621 gattggcggc tgagaagtcg tcgggagctc attatgtttt ttcacttctt cataaaagct 3337681 tttccagtcc aactcaattt cttcacggta agtctcctcc ctaaaaacaa cctggagagg 3337741 gatcatatgt atctgatgtt gttcacgcat ttctttcgga atatatgccg tgctgtctgt 3337801 tacgactgca atattcatag cttcgatacc tgccttattg ctttataact ctattgtaag 3337861 ggaaacggca gcctaaaaaa agacctgcct agtaaaaggc aagtctccta ttatactatc 3337921 tcatttctac ccagccattt ttaatggcga ccacaacggc ttgcgtccgg tcgtttacat 3337981 tcattttttg taaaatattg ctgacatggt ttttaacggt tttctcactg ataaacaatg 3338041 attcaccaat accgcggttg ctttttccgt ctgcaagcat ctgcagcact tcacattccc 3338101 gcctagttaa aatatgtaat ggtctgcgga tttcagggta aacctcatgt tgagggtgtg 3338161 cagaaactcc gcttgttgca aggcggcgga attcgttaac gaggttgtga gtaaccttcg 3338221 gatggaggta agatccgccc tcagccacta ctttaaccgc ttcaattaat gtatcagcat 3338281 ccatctcttt cagcagataa cctcttgcac ctgttttcag ggcatgtgtt acataatttt 3338341 cgtcatcgtg aattgataga ataattactt tagattcagg atacagctct acaagctgtt 3338401 ttgtagcttc cacaccattt acgtttggca tattgatatc catgatcaca acatcaggat 3338461 gatagtgctc aacaatacga gccgcttcgt ccccgtcatc accttcggct accacttcaa 3338521 aggtaggttc aaaatccaat atccgtttaa caccttcacg aaataactga tggtcgtcga 3338581 taataacaat gtttacttta gtcacaagcc acgcctcctt gtattattgt tctatatact 3338641 ctagcattcg gtcaatatgc cttttggctc tattttacaa atcatagtca aagagataac 3338701 ggaaccttaa tcataataaa tgtcccaaga cctattttcg aatctattgt catcgttcct 3338761 tccaataaat ctactctttc tttcatgccc agcaagccga atgatttgtt tttcttctct 3338821 ttcgcttcct tcaggtcgaa ccctttaccg ttatctttta tcattaaaat cacaaaatcc 3338881 tttgtgatct caactttgac tgtaatttct tcagattcag aatgctttag cgcattagac 3338941 acagcttcct gtgcgagcct gaagagcgca acctcaaact gaggcgctag cctctgatcc 3339001 tctgtttctc caatgcactg aaaatgtatt ttgaccttcc cgttatattc ctcggttgta 3339061 tatagatatt ttcttaaagt tggaatcagg cctaggtcat caagggccat cggtcttaaa 3339121 tcatatataa tccttctcac ttcgtaaagg gcattccgaa cattttggcg gagattttta 3339181 atttcttgga atccgtcctc tgcgccccgg tcacggaaaa tccgctcgat taattccgat 3339241 ctcatcataa cattcgccag catttgagcg ggtccgtcat ggatttctct tgagactctt 3339301 tttcgctctt cttcctgcgc ctcaataatt cttaagccga aatcctgttt tgcctgagca 3339361 tcagcaagaa gcagtccaac ttcgcgcaaa tcctgattca agtagttgag cacaactgta 3339421 atttggctta ctaatgattc tgaccgctca atgatttcct gaagccctag caatctgcgc 3339481 tccaaatcgt cccgccgttc gcgcaattgc ttctcacgct gctggatcat cgtcaattct 3339541 acctgcagct tatgggcttt ttcataagca ttgcggattt cctcttcact gaatctatga 3339601 aaattacggc tgacctcgga taaacggttt ctcgcatggc gagtttgcac ttcaagttta 3339661 tcgccaagct caatcacttc atacacctgc tgtttaattt gtttcagttc ttcgaccagc 3339721 tgttcatact gctggcgtga ctgctccccg atttgaaaaa cctcgtcctt gctcccgtca 3339781 acggttttca gcatcttcat caaaatagaa tccagcactt tggaatccat ctttgtttta 3339841 ttcataattt ccctccgtca cggcgttgtc atatattttt attataaatg taattgatct 3339901 gcaaattatg tcgaattata atgaaagaat gcgtatattc tagaaaaaaa catttttata 3339961 tactatctac tctttatgat accaaaatac gcacaaaaat tctaaagact gtacgaattt 3340021 gtataggcag tcttttatgc ttagcaggag ggtcagctag catgctgcac agctatttta 3340081 ctgtgaaaga agcgggagaa cacgagattg ttatagaaaa atcgcgtttt atctgtcatt 3340141 taagccgtgt ttctaccgaa caagaggcac aggaatttat acagaaaata aagaaacagc 3340201 actggaatgc gactcataat tgctcggctt atgttattgg cgagaatgat catatccaaa 3340261 aagccaatga tgacggggaa ccaagcggta cagcgggagt gccgatgctc gaggttttaa 3340321 aaaaacgcag gctgaaggat acttgcgccg tcgttacacg ctacttcgga ggcattaagc 3340381 ttggtgctgg cggattaatt cgcgcttatg ggaaatcagt gtctgaagga ttaaatcata 3340441 taggtgttgt agaacggaag cttatgcgaa tcatgcatac ttctgcagat tacacatggc 3340501 ttggcaagat tgaaaatgaa ttaagggagt cacaatttct gttaaaggaa atccattatt 3340561 cagaaaatgt tgaattcgaa acatacgtgg aagaaaaaga aaccaacgct ttttctgaat 3340621 ggatgacaga actgacaaat ggaaagagtg atattaaaga gggagagttg acgtatcttg 3340681 aaaaagccgt caatcacata aaggagactg aataatggct gaacgcgtta gagtgcgtgt 3340741 gcgaaaaaag aaaaagagca aacgtaggaa aattttaaaa agaataatgt tattgttcgc 3340801 ccttgcacta ttggtagttg tagggcttgg cgggtataaa ctttataaaa ccattaacgc 3340861 tgcggatgaa tcgtacgatg ccctatcccg cgggaataaa tcaaatcttc gcaacgaagt 3340921 tgtagacatg aagaaaaaac cattttctat tttatttatg ggaatagagg attacgcgac 3340981 taaaggacaa aaagggagat cagactctct tattgttgtt accctggatc ccaaaaataa 3341041 aaccatgaaa atgctgagca ttccgcgtga cacacgtgtg caattagctg gtgacacaac 3341101 gggaagcaag acgaagatca atgccgctta cagcaaaggc ggtaaagatg aaacagttga 3341161 aactgttgaa aacttcttgc aaatcccgat cgataaatat gtcacagttg attttgacgg 3341221 atttaaagat gtgattaatg aagtcggcgg tattgatgtt gacgtgcctt tcgatttcga 3341281 tgaaaaaagt gatgtagacg aaagcaaacg gatttacttc aaaaaaggcg agatgcattt 3341341 gaacggcgaa gaagccttag catatgcccg gatgagaaaa caggataaac gcggagactt 3341401 tggccgtaat gacagacaaa aacaaatctt aaacgcgctg attgaccgca tgtcaagtgc 3341461 aagcaacatt gctaaaattg ataaaatcgc agaaaaagcc agcgaaaacg ttgaaaccaa 3341521 tattcgcatt actgaaggtt tagcgcttca gcagatttac agcggcttta ccagcaaaaa 3341581 aatcgacaca ttgagcatta caggttctga tttgtattta gggcctaaca acacatatta 3341641 ctttgaacct gatgctacaa atctcgagaa agtcagaaaa acgcttcaag agcatttaga 3341701 ttatactcct gatacaagca ctggcacttc cggtaccgaa gacgggactg acagctcaag 3341761 cagttctggc agcactggca gcactggcac aacaactgac gggacgacga acggaagcag 3341821 ctattcgaat gacagcagca caagctcaaa caacagtaca acgaattcaa caactgattc 3341881 atcctattaa aaaatgcccg gtccttttag aggatcgggc atttttgcgc agaaaaaaac 3341941 tccggcacat aagccggagt ttttaattcc ttttcaccag ccgtttataa aactttgtaa 3342001 acggcttaaa tttttcattc acgagtcctg tcacttctgc tatgatttgc ataaaaataa 3342061 tcaaaatgaa gataataaac aaagaaagcc aaattgtggc acttttaagt acaatcgcac 3342121 tgatactgaa aataaatcca attaaataaa taactaagac cgacatccga tgtgaaaggc 3342181 caaaggccat cagtctatgg tgaatatgcg acttatcagg cgctgaaatc ggctgtttgt 3342241 ttaatattct tctgatgata gcaaatgttg tatcaaaaat cggtacgcct aatataataa 3342301 tcgggataac gatactgaac aatgtgacac ttttatacag gcctaataat gaaagaatcg 3342361 agatactata ccctaaaaac agtgatcccg tatctcccat aaagattttt gccggatgga 3342421 agttgtaaaa caaaaacccc agcgtgctgg caataacgac taatgagagt gacagaatga 3342481 gcacttttcc gccggatagc gccatgacag caatcgttga caggccgata acagaaagac 3342541 cggcagcaag gccatccaat ccatcaatca ggttaattgc gttcgtgatg ccgacaatcc 3342601 ataataccgt cagcggataa gccatccatc ctaactcaaa tcgttctgtt aaaaaaggta 3342661 ctgagaaaaa gtccattttt aagccagtgc ttacaatcat aatggctaca cctaattgaa 3342721 tcaaaaactt aacttttgca cttaattgat atttatcgtc aagaatacct aacacaataa 3342781 tgatgaatgc tccgactgta attgccgtca tccttgtttc tgtgtaaata ccggatgcaa 3342841 gcacgcctgc aaccaccccg ataaatatgg ccagcccgcc catgcggggc atgattttgt 3342901 catgtacttt tcgattgctg ggctggtcaa ctgcacctat tttaatcgca atccttttta 3342961 cgattggggt tatgattaaa actgtcagca gcgagacaat aaacgcaaca acaatgcgaa 3343021 tcatgcgttc gtcaagcata aagaagtctc ctttggaatt aaatgaagtc tttatttata 3343081 tagagaaccg ttccttccat tataccttct ccttagttat tataacaagc ttcatcaaaa 3343141 agaaacacgt ataatcaaaa aacgcgcatc ccaatttata ggactacgca tgtttttgaa 3343201 tccctgtata tttcataatt tgtctaaata agcaattcca atcttgtgtc cgggcgatgt 3343261 ttcggcgcat ttctttatag gtctcgtctc cgttttgacc gagaactttt tcacaagcgg 3343321 ctataaaatc aatcggatga tcgccctcta catattcgta tacatacggc ttttgcattt 3343381 ttgaggttga cggaagatta gtgcctacaa caggttttcc tgccgctaaa aattcaaata 3343441 gtttcagcgg aaacacagct tgattatacg gtgattgttt atatggcata atgccaatgt 3343501 cgataagctc catataatga ggcacttctt ttggatctgc cggaccggtc catatgacat 3343561 tgggaagcct cagcagctct tgaaacgaaa catcaccatt ggtggcatcc gggccaaccc 3343621 ataaaaatgt ccaatcaggc ttttgcagtg ccgcttcttt aatcatttta aaatcgagct 3343681 tcggtttaat cccgccaata aaacctaaca ctattccttc tctcccctgc agtatactgc 3343741 gatcgggagc ttgtttattt gcagaaaaca gctcatactc cacaccgttt tccacagtat 3343801 gaaccttttc tcgtcctgca gtcagttttt tgtctacttc cttgtgaaga taatctgatg 3343861 aacaggttat tgaatctgct cgttgtataa ttctcagctc tgccgattta atgacttttc 3343921 gccggaattc agacagcaga tttgatcggc cgctgatcgg cgcagcccat aggtcactgc 3343981 agtcataaat gacctgatcc caagaataca gcgaagacag cagcgggaat ccgggaaacg 3344041 tgtaccataa acagcagcgt tcaccgtttg cagaagcagg tgtaagctca tcgagtaatg 3344101 gggagagctt atgtctgtaa aagacatctg tatatcgtcc gaaacgaaac atttttttct 3344161 gcagcaggtc tttgacagcg aattgcctga tgccagaatg gacttcctga aactctttcc 3344221 cttgggcacg cggagccgga catacccaaa taacttcctt cgtttcctcc tgagcagcta 3344281 aaaattctgc cagccggtgc cttctgtatc tcaattggtc ttttccccat tcagcagtgg 3344341 caacgatgac atgaatgatt gcttcttttg tttccacctt catcaccttt tctctctgtt 3344401 tgcagctata atcttttttt caccgcgttt tttgcatatt gaacaaaaca ccatgttgct 3344461 ttcataaaat gaagccgttc gatctccctg tagacaaacc acgttttttt cgcagccttc 3344521 catttgttgc tggaaattga attattgaca agccgatatt cagccaggca ttcattcatt 3344581 ccataggcag taaatccttt ttttaaaaga gacagccatg tggctaagtc ctgtctcgtt 3344641 ctgatattcg gcatttggat ctgtcccgtt tgctccctgt caatcatcac cgtcaagcag 3344701 ccgataattg tatttttcag ggcgtcatcg tacgtcaggc tttccggcgc atgaataaat 3344761 ttatcgagcg gggtcccgtc ctgcgccatt aagctgtagc ccgtgaaaga gaacgcacag 3344821 gagcgctcca tcataaactc aagctgcttt tccagtttgt cttttttcca tttgtcatca 3344881 ctgtccaaaa atgctacgta gcgcccttga gcgcgttcca acgctttgtt gcgagcaacc 3344941 gcagctccgg agttctcttc cagatacacc acatgaattc tttcgtctat tttttcatac 3345001 tgctgtaaaa tgtcgcgggt cccatccgtt gagcaatcat ccacgataat catttcccaa 3345061 tgaggatggc tctgatctaa taccgaatga accgtgtctt caatatagtc acgcgcatta 3345121 taggaaggtg taatgacaga tacgagaggt ttccaattgg tcatgatcac atctccatcg 3345181 tatgatttta aaaggattct ctgaaaaatt caggaatgac aacgaacata aaggcaatcg 3345241 taaggccaat cataacgccg agaactgctt tctttttcgg agacataccg ccgcctgctg 3345301 tctcacttac ggtttcggaa tcagtaacac ttgccgcttt caggttaagc tgtgtgtttt 3345361 tgagttcata taaaaatctc tctttatcca ctttggaatc ctcgctcacc gactcgcctt 3345421 caagcgcgtc tatgctgctg cggatgacgg cttctctttc tgcatacagc ttttgatcgt 3345481 ttttgaggaa ggtggaggat atggcgttta agacagattc cgttctatcc ttatcctcgt 3345541 cactatagct taaagtcagt aacgatttgg attccgtatt gattgtaagc ttctctttga 3345601 tctctgctac atcttcatcc ttttcatcag gaagcgcctc cttcaaaaag gagtcgctct 3345661 ttaatagaag cggaatctct tctgtgctgt tataaaccgg atgatcatag ctccccacag 3345721 ccaaagtatc ttcagctgta tagctctttt gatcagcgat ctgtgacggc aggatatacc 3345781 ccgccgcacc taatataatt ggcaccgcta tgatccaaat gatatttttt tttatgcgac 3345841 gggctattct tatcaatata tcgttcatat aagtctccct gctttttgta gtctgtttat 3345901 ctgtacatcg gctcaggcat ttgtctggat cgccttaaca cattcacggc ggcgatgacg 3345961 agcgccataa acacccaatg gaaaaataaa tttgaaacag agcttgggct gatacttgat 3346021 accaggaaac tgaccatagc ggtaataagt ccttctgtga tcagttttga ctgattttct 3346081 aattttcttt cataaaactt gtaaagcacc catatgaggt aggcataaac ggacaaatat 3346141 cccagcatga tgaacaaacc aaaattagca agaatttcaa caagccagtt atgcacctct 3346201 gccacattgt cagtatcata tacagcataa tgctcaagat aataggatac atttcctgcc 3346261 ccgactccga atccgtatga atcaaggaaa aaatgccaag cgtttttcag cagatttgcc 3346321 cgagccacat ttgatggaag cctgtcatga aatgaatgca gcgtctgcgg ggccagaaac 3346381 agctcccaaa actttgaata gattttgctg gcgaaaagaa ctgcgaaaag agcaattccc 3346441 gccgccgaca gccatatagc cattctcttt aaaacaggcg gcaatacaat gaagatgtag 3346501 acagcaatac ctgcaaaaat gcccagaagg ctggctcttg aaccagtggc aaaaattaaa 3346561 tacaacgcac agagcgagag cacaaggcca attgccttga tgtatccatt cttaatgttt 3346621 ttcatcatcg tgatgtaaaa aaagaagctg atggataaaa aggtcgcaaa gtcattttga 3346681 ttaaaaaaga ccgatgtcgg ataatgctgc ttgtactccg gtccgctgta caatgtggaa 3346741 ctcgcaagat gatggtgggt gatatgattg taaaaaccaa tgatcatcag aaataccgtc 3346801 atcaccagcc aaatggcata aacaatcatc agccgctcca ttttttgcac gtacatgaca 3346861 ataagataaa tgaagaagat ccccattgcc aataaggcta aatacttgag gccaactgtt 3346921 accgacttgg cccacagcag agaaacaagg ccatatataa accaaaaggc gaaaaagagt 3346981 aaaatccctt ttacttgcag cccatgccat ctttcaatat gggttcgatt ccgaaccatg 3347041 ccgaaaatat gaaggcaacc cgctgcaatg agcagaagcc ggtaaaggaa caaactgaaa 3347101 aatccaagat gaatggcaaa aaatgcatta tttaaaaaag tgcaggcgat caaaatatag 3347161 attacagcca taaagagccg ttcttttgtt gtaaatgcgg ttgcaagcgt cagtaaaaac 3347221 aggccaattg ccaacaccgc aagcacagca gccatctgca tgaaacctat atctttatgg 3347281 atggctccca gcaataggac gactccaaat atagcagcgg ccagtaacgc tagcgtatgg 3347341 accgctgatc gtttgatact cacatgttta acccctttcc tgatgtttca ggagccggcg 3347401 gccgagccta gcagccggca gcttcaacca agtaacactt tttcttttta taaattgacg 3347461 cttcccaagt ctttagccaa ttcttcaagc ggcaagcccg gaaaatactt gtcagagggt 3347521 tccgttcccc gaacagcggg acggccgata gagtgataaa tgtatccggc tgcctgcatc 3347581 tcttcaagtg aaaataaatt tctgccgtca atgatgactg gctgttttaa gagggttttc 3347641 acttttacaa gctccatttc tttcacttcc ggccaatccg ttaaaatcag gcatgcatca 3347701 gtgtcttcca tcgcagcata cacatctgtg taatactcga cctgttcgcc aaggatcgct 3347761 gaagcttcag gaatagcaat cggatcgtat gcttttacat gggcgcccag ctgctgcagc 3347821 attgggataa tatcaagcgc tggagcggat ctcacatcgt tcgtattcgg tttgaaggct 3347881 aatcccagga ctgaaatggt tctccctttg acgcttccca taacagtcaa aagtttatct 3347941 acaatatgaa cacgctgctt ttcgttcgtt tcaatgacag cttcgatgag cttgaatgga 3348001 tagcctgccg attttgcgat ttgaagcagc gcggttgtat cctttggaaa acatgaaccg 3348061 ccgaatccaa taccagcttt aaggaacttt ctgccgatac ggctgtcaag accaacacca 3348121 tcagcaactt ttgaaacgtc tgcgccgact cgctcacaaa tgtttgcgat atcgttgata 3348181 aaggaaatct ttgtcgccag aaatgcattc gcggcgtatt taatcatttc tgcactttct 3348241 aggtttgttt taatgacagg agcatggaat ggctgatgaa gttcctcaat gatggcagcg 3348301 gctttatgac ttgttgaacc aatcacggca cgctccatat tcatcgtgtc atgaatcgct 3348361 gacccttccc gaaggaattc agggttagat acaacatcaa atgagtatct cccctttgag 3348421 gctttttgaa cgatagattg caccagtttc cctgttccaa ccgggactgt gcttttattt 3348481 acgatcactt tgtagccgtt aagatgctca ccgattgttt tcgccgccgc tttgacgtac 3348541 gttaaatcag cttcacctgt tttggacata ggcgttccga ctgcaatata aataatatct 3348601 gaggcccgaa tggcagacgg gatatcgttc gtaaaggtca ggcgctgatc cagcacattt 3348661 ttttcaacta agtctgcaag ccctggttca tagattggga ttaccccatt tttcaggctt 3348721 ctgatttttg attcatcgat atcacagcaa acaactttat tgccgatctc cgcaaagcaa 3348781 gtgcctgata cgagtcctac ataacctgtt ccaatgacag ctattttttt cacagcgctc 3348841 aaccctctcc tgtaaaatga tcttccaatt tataatggtc gcagtgtctt acgattaaac 3348901 ggacgttttc gtgaccgtct gatactgatg atgcaaggcc ttggcgtttt ttcctgcgtc 3348961 aaattgagcc tgcacggttt catacaagtc atctgctact tccggcttcc atatttgctc 3349021 atgttcgtac cgagtgatcg cttccgccaa ggcttgagcg gatttcggtt taatcagcag 3349081 atgttggtgc tttccgaata aagacgacac tccgccaaca tccgtacaaa taacaggaac 3349141 ccttagcgcc agcgcctcaa tcacaacagt cggcatcccc tcactgtaag aaggaagtac 3349201 gaatagatct gccgcaagta aatagtctct tacctgatga ttcgggactt ggcctgtgac 3349261 gatatgcccc ttctgcgtca gcgtcgattt tgcgggacca tccccgacaa agactgcctt 3349321 aggagagtcc tgcagcgatt cgatcgcttc agacagttca aaaatgcctt tctctctgac 3349381 cagccggccg acatagacag ccagacgctg atcgagcggg agtccgagtc tttttctgat 3349441 ttcctctttc gtctcctcat tcccctgaaa acggctgagc tgtatgccga ttggcaaaac 3349501 cgagctgtca aagcccgaaa gctttttggc ttcttcctga agcttgtggc tgactgctaa 3349561 aacaactgac gcagaaccta cggcacgctt gaaggcttta aacgcacctt tgctgtaatg 3349621 cggatagaca ttcacatcac tgccatgcaa ggtcaggaca taaggaattt gcgctgactc 3349681 tgacacgact gccgcagccc cgcccgatgg catggcaaaa tgcgcatgga tcagatccgg 3349741 atataggtcg cgctgtttca ttgtttttaa aacggctgat gcgattctcc gatgaggctg 3349801 cgcccacttc agctggccgg gaactgcccg atagaaaggc cggtaaaccg gtatcccctt 3349861 tctaatctca tactccggtc tgacatcctt ttttcgatat gtctttttca gcatgcggac 3349921 aggtgctgaa tgaaaaggcc gtgggcatat cacagtgata tcaagcccga gtttttgcag 3349981 ctcttgcacc tgtgtctcat gaaacacacc ctctccgggt ttcatactgc tcggatatac 3350041 gcttgtgatc cacaaaatct tcatgacaaa cgtccttttc ttagtagttt gcttttcgtt 3350101 tgagggtacg cttttaccaa aagaaagaga tagcacagcg ccccagccgc aactgaaatg 3350161 gccagccgca tttctgcctg catactgaag tgttcggtac tgaggcttac accaaacgcg 3350221 atgatgccca tcgccgcagt aatcagaaat ggcttcataa tcgactggaa ataagctgaa 3350281 aggttaagct tgatgacata tgccaaaagc cagcgcccaa tcaggaaatt aacaacgctg 3350341 ataatggcat acacccatgc gactgtcagc aggcttcccg tctgtacagc tgcaaacagt 3350401 gataatccgt acagcagcag cacgccggaa tcccaataaa acgctaagtc agctcttcct 3350461 ttagccagca acacagatcc atttggattc atgagcactc ttagtattcc gacaatcgca 3350521 agaacattta ggatcggaac agcagcaagc catttttctc cgaaaaccgc tgtgataaag 3350581 gcgtctgaca cagacacgag cccgattaac agcggaaacg aaacaagcgc cagcattttt 3350641 gtcatattca gaaagccttc tctgatcacg ctgttttcat atttgttttt tgcgaaaata 3350701 gggaatgcca cccgtgtgac aatcggattg atcttcaaaa ccggaatggt gacaatctga 3350761 taagcgaggt tataaatccc caatgcttca gcaccaataa accggccgat caaaatcatg 3350821 tcgatatttg ctcccagcct gttcacaaga cgggatgaaa gctgaaaggc tccaaaagaa 3350881 aagaaatcct tcatgcctct caaatcaaaa acaaaagcag gatgccactt ttttcggtat 3350941 acagcccaat ataaaatccc tttactggac tgcagcagga cttgagaaat cacgtacgcc 3351001 aaaatcgcat ccatcataaa aaccgctatc gctaaatatc cgaatgacaa tacatttgaa 3351061 aaaatctcta ttttgcttaa cgtattaaaa tgcagctgct tttgcagcat atactgatat 3351121 tgctgtccaa ttggcgcgat caaaaacata atcgccagaa tccgaaccag aaacaccagc 3351181 tcttctcttt gataaaatcc cgcaatgaca ggactgctca catataaaag aacaaacagc 3351241 aaaacgcccg tcataatgtt aagccaatac aatgttgaca gctggcgctc cgtcgcgtcg 3351301 tctctctgaa ttaatgctgc gccaaaaccc atatcgagca caatctgggc gaaaactgta 3351361 accgttgtga tcatgccgac aagcccaaat tctgttaagg tcatcatatt tccaagcagg 3351421 gcaaactgaa caatttgtat gattgtaata cacatggttg aaatacttgt ccactttgca 3351481 ccgctcatga tttgttttgt aatacttggc atcatattcc ctacttcttt ttaagctcag 3351541 attgatggtg aataatggaa tcccgtttta tcttgcacca tcacccgtcc aaactacttt 3351601 acaagttttt aacataattt ttaattctaa agtgaaagtc agattgcgaa tgtaatataa 3351661 atcaaatatc agcttttcct tcggcgtcat atcgtaaccg ccgttcacct gagcccagac 3351721 gctgtgtaaa gcctggaatc tcattctgga atttttccgt aaatacgggc cgttccggac 3351781 gagggccaat catactcata tcgcctttca gcacattaaa cagctgagga agctcgtcaa 3351841 ttctcgttct tctgataaaa gctccgatcc ttgtcacccg cggatcttgc ttctgtgccc 3351901 aaaccgcccc agacttctcg gcatctattt tcatggaacg aagcttataa agcttaaatg 3351961 gcttcccgcc tttccctacg cgttcctgcg tataaatggc aggccccggc gtctccaaac 3352021 aaatcaaaat tgaaaatacc gcaatcattg gcagcgcaat cgccaatcca atgagcgcaa 3352081 accaaatatc cattacgcgc tttattgcca aataacgagc cgtcttttca gataatgtaa 3352141 aagaatgtat ttgttgaact gagaattcac gactcacatt catgcttttc tctgcactca 3352201 ctgacacaca cctcacgatt tgtttgggat gttatgatga cctatgccag tcagtttagc 3352261 agacggatgt taattggatg taaatggtat gttaagaagt gtgaattacg tgttttttct 3352321 gataaatgtt gttaatactc ttttactatt ttatatacaa gtcctatttg ttttaatcat 3352381 ttcatataaa aaagagacaa atctgtgatt agatttgtct ctttcgatta tctgtaataa 3352441 gatactgtgc cgtcatgaat agcttgtgca gctttatctt tataaaccgc ttgcttcaat 3352501 ttacttgcat ctgatgcatt agtgataaag gcagtttcaa ctaaaacact cggcatttta 3352561 gaatatttaa taacatagaa agcagctgtt tttactcccc ggtctctcgt tccaagatta 3352621 gccgctaact ttggttgaat ttgttcagcc agtctcttgc tatttgcagc ttgatatgtt 3352681 gtatcgtagt acgtctcact tccatttggt gatgagctat cattagcatt tgcatgtata 3352741 ctgagaaata aatctgcttg tgcagaagct gctttattta ctctctcctg taaagaataa 3352801 aaagtatcat tagatcttga cagtactgga agagcacctg aagcatttag ctttgtattg 3352861 actcttttcg ctatatcaag gttgacttct ttctcaagga gtccattgcc gattgctcct 3352921 gaatcttgat caccgtgacc cggatcaata aagattgttt cacctacaac tggattcttt 3352981 agctgattag caacctttgt gcttacggca ggagtgtttc cgataatcat aaagtttgac 3353041 atgtttttac ttccaataat tttacgggct cctgtagata aattttcacc atttgtaaga 3353101 ataagagatt gcttcttctt agctgccagt gtagctcctg caatagagtc agggtagctg 3353161 aatccattgc ttacatatac ggtgcttgtt gataaattaa gtttttgtac gatatttgca 3353221 gcaagctcat atctgtttga accgctaatt cttgtaggag aaggtaactt gttgtatacc 3353281 gtattgctga tacttccagt gcctcctaca acaacggtac tcgaaattcc cttatctttt 3353341 atcacagacg tagtcgcact atttatagat gttttatttg taaaaagaat tggatacccg 3353401 tttttcgctg cataagggat gacggccgga gcgtctgcat ataagaagcc gttcaaaata 3353461 acagcttttg aagtcgcacc catcgctttt gccacccgtg cagccgtatc ataacggttg 3353521 cttcctgcaa ttcgtttaat acttatcccc aagcttttaa tctggttagc agtgttagaa 3353581 gaaacagcag gtgttccgcc tacaataatt acatttttag tctgcatctc tttcaatctt 3353641 gttttcgttt catatgaaag cttatcagaa ttagtgtaaa gcaatggcgc attcttctgg 3353701 taagcaagag gtgctgctga aatagcatct gcataggaac tcccaccaac aattacagct 3353761 gtacttgctg ttgaatacat ttgctttgat atttgtacag cagtgccgta tctattgctt 3353821 cccccaactc ttttcactga gttatcggcc aaagctgttg gcacaaaaag tatgagcccc 3353881 agaaaacaca ttgttaggac ttttatataa gaacgcaatt gatttcctcc ttaaatggcg 3353941 ttatatccta aaataatcaa taacttgtca gagttgtacc tggatagtaa aatttcaaaa 3354001 ttgaactata tgaatctcca gcttctgctc ttgcttttgc tccatattga ctcattccga 3354061 tcccgtgacc atatccttta ccgctgattg tgtactttga agtatctttt tttacagtca 3354121 cataagtact tttaaataca gtcgctccaa tcattgttct taactcactt gttggtacac 3354181 taatggttgt aattttgctc aagttatagg agccagtact gcttttaaca aaatacttca 3354241 ctttcatcga tgctgttttt gcacgctgcc cttgtgtcgt tccactaaag cttaaatcgt 3354301 caatacttgc aattttgaca gaatcagcgc ttgtttcttt atttttcaag atccagttct 3354361 taactccgga aagtcttgca gaatcagttt cagtcgctga agaccaccaa gaagaaggct 3354421 tcgttaagtc caaagatttc gtatctagct gttgttttga caaagtaagc gtccagccta 3354481 tttgaggatc ctttgtatct ttttttgcaa tcaagtaagg tacacttgac gaccacactt 3354541 cattactagc ttctgtgtaa ccaccattac tggaagaata agctgcagtt ataagagatc 3354601 cattatattt cagaactttc cccttcgttt gctctaccgc tttattggta ttcgaattcc 3354661 aactgtagcc accataaact tgaaaagcgg ttgtatcagg tacagtagtt cctgtttttg 3354721 ttattgagta ggttcttgca gcgacagtct gtgctttaag agcctcaagt gaccagctag 3354781 caggcatttc attcggaatt actcctttta agtaatcctc aaatggaata ttctcattta 3354841 ccggtcggat atatttagta gactcaatag agaaattaac cgtgccaaga tactgctttc 3354901 catcaagact aattctgttt gaagtagaat agttttctgg tttaattctt agggagtttc 3354961 cgtaagtttt gatgttttca aggtttaatt ttccgctgtt gatttttaga ttataggtgc 3355021 caccgtcagc taaataaaat tcatcagcaa gtgaattctc aacttcagca gaaattgaac 3355081 tggtacttcc aataaagtcg tatgcatatg tggctttatc tttcgttata cttttagccg 3355141 cagccggaac gctatcttgt ttaacaaata aaatttggct gtttttcttc gaggcaagcg 3355201 aagcgcctat caatacgtct gcatattttg tcccgttcgt cattacgact ttatcagcct 3355261 tcaactttag ttgcttaatt atatttgccg taagttcata tctggttgat ccaggaatcc 3355321 tttgcacagt tgaagttttt ttaatttggt tttctacact atcactgacg ctaaatgaac 3355381 tgcctataat gatgacttgt tttggcaaat cataatccgg aagcttgtct ttctctgtaa 3355441 gcaaaatagg gtatccgtgt gctgctgcat atggagcaat ggctaaagcg tcttgaaata 3355501 ctcttccggt tacaacgatc gctttatcat agctgcccat ttgctttgca atattttctg 3355561 ataagacata tctatttttt ccgcttatcc ttttcacagc gccatatgat ttcagcttgt 3355621 tttctacgtc ttttgaaatg cttcgcgctc ccccaatgat taaaatatta tcagggttaa 3355681 acttagcaat ttgtctttca gtagtttttg ttaacgtgtc aggctgagta aataaaactg 3355741 gtgcgttcag ttttttcgcc aatggaataa caggcaatgc atcaataaaa atatctcggt 3355801 tcaccaatat cactgtatta ggatttttcc actggctgtt ggatgcaaga gtcgcagttt 3355861 cgtatcgtga agcgcctgca aaacgatccg taacagcaac attatctcca gttactttat 3355921 aaaatcctgt tggcgataga ctgatgctag atttatttcc aatataattt aacaatttaa 3355981 ctgagatgtt tgagtctgct gcaaaagaaa ctgatggaat caataataag attgcagcaa 3356041 gtgaacacac tatcaattgt ttgcaagatt tcaaaatttc aggttcctcc ctatatctta 3356101 gttggcacgt tcaatatctt ttaacagaag ctgaccctca tcattttttt catatgtaat 3356161 cgtgacctta tctccactgt taaacttatc aagatcactt gtcgattctt cagtgatatc 3356221 aagactaacc ggctcattat ctactgttac ttctattgta tgagtatcag ctaaccctac 3356281 ataagtacct tcttttgttt caatgttact gtctggcgat acatcttcac cttgactctt 3356341 ttgactatta accccgcaac ccgaaagaag caatataaag aacagtaaag caataaattt 3356401 tttcattttt ttcacctcat tatattttat cgtcaaccta ttttatattt taaagaaaaa 3356461 ttaagaaaca atgaaacttt tttttataaa aaacgactat tttaggattt cattcttgta 3356521 ttaaatagag ttgtatttat tggaaattta actcataatg aaagtaattt aacagacgag 3356581 gtgcaaagga tgagaaacga acgcagaaaa aagaaaaaaa ctttattact gacaatttta 3356641 acgataatcg gacttcttgt actcggaact ggcggctatg catactactt atggcataaa 3356701 gcagcttcaa ccgtggcaag tattcatgaa agcattgata aatctaaaaa gagggataaa 3356761 gaggtcagta tcaataaaaa agatcctttt tccgtcttaa tcatgggtgt ggatgaacgc 3356821 gacggcgata agggccgtgc cgatacgctc atttatatga ccgttaaccc aaaaacgaat 3356881 acaaccgaca tggtcagcat tccgcgtgac acgtatacaa aaattatcgg aaaaggcaca 3356941 atggataaaa tcaaccattc atacgctttc ggcggcacac agatgacggt agacactgtt 3357001 gagaacttcc tcgatgttcc ggttgattat tttgtgaaag tgaacatgga aagctttaga 3357061 gacgttgttg atacacttgg cggcattaca gttaacagca cattcgcgtt cagttatgac 3357121 ggttattcgt tcggcaaagg agaaatcacg ctgaacggaa aagaagcgct cgcttatacc 3357181 cggatgagaa aagaagatcc gagaggcgac ttcggacgcc aggaccgcca gcgccaagtc 3357241 atccaaggta ttattaataa aggcgctaat atttcttcca tcacgaaatt cggagatatg 3357301 tttaaagttg ttgaaaataa tgtgaaaacg aacttgacct tcgataacat gtgggatatc 3357361 cagtccgatt acaaaggtgc gcggaaacat attaaacagc acgaactaaa aggtacaggc 3357421 acgaaaatca atggaattta ctactaccaa gctgatgaaa gcgccctttc cgatattaca 3357481 aaagagctga aggaaagcct cgaaaagtaa aacaaaaaga agcttcgcac aatgtgcaaa 3357541 gcttcttttt tatttgcctg taaatgaatc cggttgttct tttcgatacc cgtaatgaaa 3357601 cagcaattct tccacaatcc ggcgggaagc ctctccatct ccatacggat tagaagcctg 3357661 ggacattttc ttgtactcat caggatcagt taacagctgt tttgcaagct gataaatgtt 3357721 ttcctcatcc gtacctgcaa gtttcagcgt tcccgcttcc actccttcag gccgttccgt 3357781 cgtatcacgc agaacaagaa ccggtttccc gagagatggg gcttcctcct gcacgccgcc 3357841 cgaatcggtc aatataaaat gcgatttcgc tgcaaagtta tggaaatcga tcacctctaa 3357901 aggttcaatc agatgcactc tgtcagaatc accaaaatgc ttatgagccg cttcccggac 3357961 aacaggattc aggtgcacag ggtaaacgac ttgtacatct tcaaattccc ctacaattct 3358021 gcggatggcc ttaaacatgt tttccattgg ctcacccaaa ttttcccggc ggtgagcggt 3358081 caagagaatc attttatcct cacccacctg atcgagaaca ggatgtgagt aaccatccct 3358141 aaccgttgtg ttgagtgcgt caatcgctgt attgcccgtt acaaaaatag agtcggcctt 3358201 tttgttttct tttaataaat tgtctttcgc ctggcctgtc ggagcaaaat gcaaatcagc 3358261 aatcgcccct gtcatctgtc gattgagctc ttccggaaac ggggaatact tattccctgt 3358321 acggagcccc gcctccacat gaccgacagc aatttgatgg taaaaagcgg ctaggcttcc 3358381 ggcaaacgtc gtcgtcgtat caccatggac aagcacaata tcgggtttga tatctttaaa 3358441 caactcatcc aatcttacaa gtgcgttaga cgtaatctct gccagtgtct gccgctcctt 3358501 cataatgttc aaatcgaagt caggcttgat gtgaaacgca tctaacacct gatcgagcat 3358561 ctgtctgtgc tgtgcagtta ccgttacata ggaatctatt tcaggatatt ttttcaattc 3358621 aagcacaagc ggtgccatct tgatcgcttc aggcctggtc ccgaaaacgg tcatcacttt 3358681 tagttttttc atatttgtca cctggttttc tgctatagta aataaattca tactacatat 3358741 tctacatgaa aatgcatcat tttaaatcat ttcattcttg attcaaataa aatgatataa 3358801 gttttaatat taaggataaa gcttgtttaa aaatggttta tccgatatca taaaaatgtg 3358861 taaaaacata ttgaaaaggg taaatagaga atagtttaac cataaatttt ttcgatcata 3358921 aggaaggtgc cttttaaatg aaaaaagtac gtaaagccat aattccagca gcaggcttag 3358981 gaacacgttt tcttccggct acgaaagcaa tgccgaaaga aatgcttcct atcgttgata 3359041 aacctaccat tcaatacata attgaagaag ctgttgaagc cggtattgaa gatattatta 3359101 tcgtaacagg aaaaagcaag cgtgcgattg aggatcattt tgattactct cctgagcttg 3359161 aaagaaacct agaagaaaaa ggaaaaactg agctgcttga aaaagtgaaa aaggcttcta 3359221 acctggctga cattcactat atccgccaaa aagaacctaa aggtctcgga catgctgtct 3359281 ggtgcgcacg caactttatc ggcgatgagc cgtttgcggt actgcttggt gacgatattg 3359341 ttcaggctga aactccaggg ttgcgccaat taatggatga atatgaaaaa acactttctt 3359401 ctattatcgg tgttcagcag gtgcccgaag aagaaacaca ccgctacggc attattgacc 3359461 cgctgacaag tgaaggccgc cgttatcagg tgaaaaactt cgttgaaaaa ccgcctaaag 3359521 gcacagcacc ttctaatctt gccatcttag gccgttacgt attcacgcct gagatcttca 3359581 tgtatttaga agagcagcag gttggcgccg gcggagaaat tcagctcaca gacgccattc 3359641 aaaagctgaa tgaaattcaa agagtgtttg cttacgattt tgaaggcaag cgttatgatg 3359701 ttggtgaaaa gctcggcttt atcacaacaa ctcttgaatt tgcgatgcag gataaagagc 3359761 ttcgcgatca gctcgttcca tttatggaag gtttactaaa caaagaagaa atctaaacaa 3359821 aaaggctatt ggacattcat ccaatagcct ttttttattt caacatcaaa gtcaatgtat 3359881 gctcttcatt atcaactgcg aagacctgat caacggcctg ccgcaaaaat taataatccc 3359941 agacaaacac actgattgta gagttaaaca aactaaatga aaacataaat acaaacatgc 3360001 agattaaata gtaaatatct tgtattcaat gcaagctaag taaacaccac ttgctaaaag 3360061 aacaatgact aaacaaccag cattacaaaa taattaaata aatttgaagc aattacaaca 3360121 gaaggcagtg aactgtcgga aagttcattt tggctaccat attaatccct ttaactacgc 3360181 tgttggattt atcaagaatt gtcgggctaa tagaaaacca cggaatcaaa ccagccagca 3360241 ttcaaacgat aaaaggcact tctccgatac ctgttatgac cagcttactg ttgcgcatcc 3360301 caaatacaaa ccagtacgcc atcattagaa taaggggatt taaaacctgc cataatacac 3360361 caaaataatt gattttttgg atctttcggt taaagaaatt taaaagtacc agtgaatatt 3360421 gtaacaaatg ttgagttttt ttcactttta aaaagtaaag agaagtctcg cagaacttct 3360481 cccaacattt gaagtgtcaa tataaaacaa accaacctca tttagcaact ttattattat 3360541 ctaattccaa aatagcatta taaatacgat tcctattatt tttatcagta tatgcaaaaa 3360601 agttatctac tctttttcta tacttatctt ccatacgact attgtttttc atataataga 3360661 taactttatc cactaagcta ttatgatttt ctaatacatc accaaacccc atttttttat 3360721 aatcataata atcaagttta aaatggtatg acttttcgta ttgataataa ataacaggtt 3360781 ttttctcata tgcaaaatca aacgcaacag atgaaaaatc agtaatcatt atattagaag 3360841 aattaaatag catttgatag ctgctgttat agtcggcaaa ctccacataa tcatgctttt 3360901 caaagtctac aatctgttgc tgaatatctg ggtgaggaaa aaaagttatt ttataattat 3360961 ttttcttagc aaattcgatt agccgttcat cattaatcaa agcattatac ctagaaaaat 3361021 attcactatc tttaaatttc gggttgtacg gtcttactcc ttttgcctga tctttcggta 3361081 atacaatatc ttttctccaa gtcggcatta ttagaagttg cttttctccc tcactcttct 3361141 taagattatc gtatctcgga aatccaccca acaaaatatt ctctttttta tagttgtaat 3361201 tccctttcac aatagaccga tattcaggtt tggcagaagt gactaataat ttgatattct 3361261 tgttgtattt gtttaaccat tcagaatgat ctgccattgt tattccgtgc tgtaaaaaga 3361321 taaactcaaa gttaaataaa tctctaaaat aaatctccat attaaaaaat ggatttacaa 3361381 cccatatatc tgcatgtgtc gatattactt tggaagagga taaggttaaa attttatgtc 3361441 taaaagatct gtatggtatg acctttccat attttttgat tctgtcgtaa tccttgctat 3361501 ctttttttat tataaagtat ttttttaccc catcattctt gttgattgca tatttaaaga 3361561 ggtgctcggc attatcatca gctttgtctt gtctgtctat gaataaccat actggttttc 3361621 tattaaaaat agtgaaaaca tggtgtacca ttcttgccat cagtgccttc ttaatcgctg 3361681 attttcgttt ttttgatttt tcccctgatt tatgtaggga ttttaagaaa cgaaactctt 3361741 ttataaatct atttttaaaa ttgttttttt tgaacattaa ttttttataa ttataataaa 3361801 aaatataatc ttttttagcc acataagtat tatataaatc gtttgacaaa cctgaatact 3361861 tgaaaaaacg aagttttgtc aacttccttt ttttaccctt agttataaaa aactcaatat 3361921 gatgattatc tgctagatga cctttgggaa tatctattga aaaaccggga tattttttta 3361981 ttacttctcc taaacttata taatcattat gctgtctttt tatattcttt gcttttattt 3362041 ttgtttcgcc aattttagca taaaacttaa aacctttaga attaaacagc gagctccaaa 3362101 agccttctat gtgaatggaa tcctcatttt cttctaaaat ttcaatagtt aaagtttgat 3362161 ccgataattt cgaaacaatt ttaccttctc tgtataaata ataatcctgt tcagtttctc 3362221 tttcatatac atacctacta taattttcac cgtgctttat ttttaaagca tgatataaat 3362281 agaaatggct gacacttttt gtttcaatga tgacatcgtc gtcaatatac gacaatactt 3362341 ctcgaatcaa tgttaaaaat tcactgtatt cattttcgtc taaaggtgtt tcactgatat 3362401 ccttaatcaa taatttccac ttcaaatcat gcataaccat atattgaaga aataaaggta 3362461 ttttctgttc atgatttttt ataatatcga ttaaattctt tgagaaagtg ataagtgaat 3362521 ggttaaacca attcttattt gctttagcag tctgcatggc agatgatcca tcttctctaa 3362581 ctctataatg gtattttgcc tctttaacca gaccatactt tttcttttgc gatatgatta 3362641 aattaactag tttggcatct tcacctattt tacaattttc atcaaacctg atatttttca 3362701 aggcatcttt ttttataaat gtagaacaac aatgagttaa tatatgatgc ggttcttttt 3362761 ctacatccaa aattcttgta gaagaaaact tattatttag attatgttct ccagttcttc 3362821 cttctgcaaa aaaaataggg attgctacaa tatcaatttc attcttatgt tcgtcaaaga 3362881 agtttaaaac attttcgaat gttccttctg aaactaaatc atccggatcc aaaaattgaa 3362941 tatatctacc ttcagcatac tttaaaccat aatttcgagc actgctcact ccgccattct 3363001 gtttctttgc atagacaatg ttattgggat atttctgagc atattcttta caaatgattt 3363061 cacttttatc ggggctatca tcattcacca gtattaactg aatattctca aaaccaatag 3363121 tttggttaat gatactttct atagcttcag tgagatacaa ctcaacatta taaatcggca 3363181 ttataacact gaaatcatag ttaaaacttt tttcgttcat aaaagattac tcctaacata 3363241 atgtttatat gaataagaat tcgggtaaat aaaattaaga aacaagagag tactaatttt 3363301 tgcaaaacaa ttttaattta gtaaaatgta tgaaaagcat tccttacctt tttttaaaaa 3363361 cccttgtaag caaactttta aaaatgttca catggttaag ttctaaagaa tcatttggtg 3363421 tttttagtac aaagtcaaat gcaaaggccc aaatcggtat ttcgacaaca aaaccagcat 3363481 atctaaaatc tcttaattta tatccccata cttcaattgt ttttttcagt tcttttcgtt 3363541 tgcatttttt taatctttta aaatatttta tatatattct gtcattttct ttcatctcat 3363601 aatactggtt aataaagtgc cctgttaatt caagtctaag cccttttatt tttgccgaag 3363661 taacagtaca tgaactatgc agtactcttt ctttttttat attttcaaga gcttctgtat 3363721 tttcttttaa taagtgaaac ataaattctt tatagtacat cggcatatct tgttctttta 3363781 taaattgcgg gtcaataaat tttaaaactt taataaaatc atcaacaaaa actctttgtt 3363841 cttgttgatc taaaacagac ttataaacat ctctatagtt cggatataaa aacagtttta 3363901 tatgatatac aattaaaaat tgcaaataag gcaaaactat atcatatttg ttgaatgaat 3363961 ccatcaacaa agtcatgtaa cattcattca acaaatatgt gtaccttttt ttgttaaacc 3364021 atgaacgatc aactaaagaa tcctgttctt tccgttttct ataaaaatac tttccttctg 3364081 caactgctcc gtatcttttt tctttcagta ataactggtt aaaaaagata gcgtcttccc 3364141 aaaactttat agattcatca aaaaggacgg tactagttag tgtatgtctt ctgtaaaaag 3364201 tgccgccaat ataaaaatga atagctttat aatcgttgag aatatttata actcttgttc 3364261 ctttttcaaa tctattattt aatttatgtc ccccttcttt ttcacctgtg taataaacag 3364321 gtaataccgc aatatttaca tgttcggaat cacaaaaaaa atcataaaca ctttgcagcg 3364381 cattttgaga gaatgcatcg tcagaatcaa gaaaaccaat aaatttagat ctttcgctta 3364441 catttgataa tccacaattt cttgcagcag aaggtccaga gttttcaatt ttcatgattt 3364501 taatattatt aggatataga tttttaaagg attcacaaat ttgaggactg ctgtcaacac 3364561 taccatcatc tattaatatc agttctatat tttccttaaa tccaattgac tggttaagga 3364621 cactctctat tgaatatctt aaataatttt cagaattata tattggtata attatagaaa 3364681 acatgtttgt acctctttat ttagaagtta aaggatcgtt tcaattactc ttttagaagc 3364741 cttgcctctt ctaaattaca aaatttatta taaaaatcct catagttatg atctatataa 3364801 ggattatgta acaactcttt taccgtatct ataagttctt cacttgtttg aagcaagttt 3364861 cctggcgttt tttgctgaaa attaaagtaa aaacctctga tacagtctct ataagccggg 3364921 agatcataca caaaaaatac aaggtttttt taaaaattca tattatcaaa aaagacagaa 3364981 gaataatcca taatcaataa atcactaatt aaatataaat ctcgaatatc tttatttaaa 3365041 gaaacatcgt tcacaaaata tttatatttc cctaattaaa ttgttctgaa actggataat 3365101 accattctta caagaataac catagagtct ccaaggttcc ctcttcattt cctctaatca 3365161 aattaaagtt aaatttatac tggccagctt tcttaaaatt cattatcccg caaagttggt 3365221 gcatataaaa ttatttttct ttaattcctt atttgataat gtagaattgg taggggattg 3365281 tagctaaact gtttccagaa tagctttcaa ataaaattaa tttattgttt cttggcagaa 3365341 ggacaaaaat tttaaacaaa actgaataaa ctctaactag taaacttctg caattggtta 3365401 taataaaaat ttcatcagtg aactccttaa agagtgaaga ttaatattta cgcaaacaag 3365461 aaaaaaagaa gcaactgaat ttacttcaag cctcttttag ttagtgcttc tataaactag 3365521 ccatatcttt tctgatttgg gtagttgaaa tgcctgctat tcttgtaagg taaatggcct 3365581 catagtattc ctttgtagac aatcgtacga ttaagtaatc ccaggttctt ttgctctttc 3365641 cagtagcttc atatgtccat agtgaaataa atcaaacatt ccgtacgtat cactttcttc 3365701 attagataac atcaccttcc aaccttttcc aacttagaaa aaacaaaaat ccttaactga 3365761 ttgtttatca tttcgacata ttttttacgt tccattaata ataaacaata atagcatatg 3365821 ttcctataaa agttaaggct ctttaaaaat gtaaatcatc agcacttttt gacaatatcg 3365881 ttgcattgat gtgtattttt tacagatctg atatcttatc tatactcatt acaacaagtt 3365941 ttctattccg gaagagtcaa ttctttttgt cgcgttttca agtgtaatga ttttctttct 3366001 gctgcgtcat ttattttgta cgccctcctc atattacttc atcgtcaaaa cgtgaaggaa 3366061 ttgtaatacg tagttcctaa aaattttcgt ggtaaaattt agtgaagtct ttatcaggct 3366121 aagggacttt atctaaacta cgaattacat atggagatat atagatgaaa aggagggttg 3366181 atatgatata aacgaaaatc aattagataa aggaaaaact gaacacttct gaaaaaagtg 3366241 ataagtttct ttcactatat cctccaaaaa gaacctaaag gtcttggaca tgctgtctgg 3366301 ttcgcgccta actttatcgg cgatgagccg tttgcgtttc tgcttggaga cgatattgtt 3366361 caggctgaca caccagggtt gcgccaatta acggatgaat atgaaagaac actttcttct 3366421 attatcggtg ttcagcaagt gcctgaagat gaaacacact gttatggcat catcgccccg 3366481 ctgacaagtg aaggccgccg ttatcaggtg aaaaacttca ttgaaaaacc gcctaaagac 3366541 acagcacctt ctaatcttgc catcttaggc cgttacgtat tcacgcctga gattttcatg 3366601 tatttagagg agcagcaggt tggcgccggc ggagaaattc agcttacaga cgccattcaa 3366661 aaactgaatg aaattcaaag agtgtttgct tacgattttg aaggcaagcg ttatgatgtt 3366721 ggtgaaaagc tcggcttcat cacaacaact cttgaatttg cgatgcagga taaagagctt 3366781 cgcgatcagc tcgttccatt tatggaaggt ttactaaaca aagaagaaat ctaaacaaaa 3366841 aggctattgg acattcatcc aatagccttt ttttatttca acatcaaagt cagtgtatgc 3366901 tcttcattat caactgcaaa aacctgatca tctgtattca caagaaaacg cttcttgctg 3366961 ctgtcataca atacatcgct atcacttaag gatagtgacg ccgggttgat aggagaaatg 3367021 ttatgaaaaa taagctctgt tgctttatca ttctccagta cataactgat tttttcataa 3367081 tcaaaattca gcgtttttct gccgtcagcc ttatttcctt cagtataacc attcaatttc 3367141 gattgaatgc tggtgctgct gtctcctagg aatttcagaa agtattcata ggaagatgct 3367201 gcgttttgcg agacataaga cgtaaatgca gtggcatgca attcagcgtg tttcatgtta 3367261 gttgcaacag cgctctgttt cacataataa gagtgcccgt caaactttat tttcgctgct 3367321 tgtttgcctt ttgcagctac cgttactttt gtaccgaatg gcagtgtaac gtcagccttc 3367381 tgtttcaaac cctgatcctt ataagcagcc gctttttcat ttgctataaa cccttgctta 3367441 ttgattgcag ttaagcgttc ctctgacttg ccctttgcat cgccatgatg gttcttcact 3367501 tcattttgcg gaatagcgcc aaacgaagca attgtacgaa gcggggcatt aaagaacatc 3367561 gttcccgcca tgaagacagt cagaatagac aaaatagcaa tttgaatggc attggccagt 3367621 gatttcggct ttttcttctt tttgcggaaa cgggcaaacg cttcaggatc ttctttcttc 3367681 ctctcttctg tctgctcttt tttatatgtc tctttttctt ttttcgatag cttattaaac 3367741 cagtcaataa acgctttgta ctctttcaca accgtttttg tttcatcaaa catacgaagc 3367801 tcgccatagt gcatccaagc aacacggtca cacatctttt caatctgacc gattgagtgg 3367861 ctgacaaaga aaatcgtttt tccttgcttt ttaaactcat ttattctgtc tacacacttc 3367921 tgataaaacg tttggtcccc cacagaaaga gcttcgtcaa taattaaaat gtcaggatca 3367981 atatgcacgg agatcgcgaa accgagacgc gacttcatcc cgctggaata gtttttaacc 3368041 ggctgattaa taaaatcgcc aatctcggca aattcaacga tgctgtcata catatcatca 3368101 atttctttat tggttaaccc catcatcaaa cacttgagcc ggacattgtc ccggcccgtt 3368161 aattggttat tcaaaccggc agcaatcgca atcagcgacg gctggccgtt catttcaatt 3368221 tcaccgctgg tcggcggaat aattttagcc agcaggttag acatggtcga ttttcctgac 3368281 ccgtttattc ctacaaagcc gattgtctcc ccttcataca cgtcaaagga gacattccgc 3368341 acagcaaaaa aaccattatc cttagccgga aaaaacaatc ctttaatctt gtccgattgt 3368401 tttttataca aatgatactg ctttgaaaca tttcgaaacg aaacttttag tttcatcgta 3368461 aaatctcctt acgtattaaa gaaagtcaac aaacttgtct ctgaatttca tatgcaggat 3368521 agaacctact aacaataaaa ggaatgtgaa caaccaaaag tacagcgtgt acttcatgtc 3368581 atggaaaaac catgctccat ctaagaagct gttccggaat ccttcaataa tatagaatag 3368641 tggattcaac ttcagaacag gcactaattc ggggtggctt tgaccgagtt tcgcattaac 3368701 atcccaaaaa attggcaaca agaaaaacaa aagtcttgtt acggcctgca gcaaaaattg 3368761 ataatctcta atcagcacac tgatcgttga gttaaacaaa ctaaacgaaa acataaaagc 3368821 aatcatacag atgaagtaat aaatatattg taaccaatgc acactcggga acacaccatt 3368881 aactaggagt acaatgatat aaatcaccat catgatcata taactaaata agttagatgc 3368941 aattgccacg gacggtagag aactaatcgg gaagttcatt ttagccacca tattaatgcg 3369001 cttaaataca ctatttgatc catcaagtat agttggactg atgaaaaacc atgggattaa 3369061 tcctgccagc atccaaataa taaaaggcac ttcgcccgct ccggttgtca caggaccgcc 3369121 ctttctaatc cccataccaa atacgaacca gtaggccagc atttggataa gcggatttaa 3369181 gaactgccat aagacaccta aataattcat ttgatattta gacttggttt cataagccgc 3369241 caatcttaaa attaaaggaa atgacgttat ttgctctctg agtatacgca acaaatcatt 3369301 cattttttat cttccttaga cttaattgtt tttgggaatc tttctgttta aaatttgaaa 3369361 gcaccgctga ttattgtaac agatcctgca ttttttttca cttctcaaca agtatctaaa 3369421 aagctgccga aaaatcgaca gctatacatt ttataaaata acctaaatta ttcagcttta 3369481 aatacagtat taacaacctt ttcagatgaa cgtcctgact ctaaatagca aaacttatca 3369541 tagaaaggac caaaagaaac cggaagctta taatcaggcg atgagatctg cttgatagcc 3369601 tcaatcgttt cttcagtagt ttttaccaaa ggaccaggag cttctttttc aaaatcaaag 3369661 tagaaaccac gcaacttgtc ccggtaggtt tcgatgtcag ggacaaagaa tagcattggc 3369721 cgttttaaat ttgcaaaatc aaagaatact gaagaataat cagtaatcag caaatcagaa 3369781 accatataca attctcgaat atcctcataa gcagaaaaat catatgcaaa tccttcaaaa 3369841 ggacctaaat caaaattctc agctaccaga taatgcattc ttaagattac aatatattca 3369901 tttccaagtt cttgtctaag ttgatgcaaa tctaaatcga gatcgaactt ataacgccct 3369961 tttgcataga actgatcatc tctccatgta ggggcatata aaataacctt tttatcacga 3370021 ggaatattta acctactctt tatcaatgat attgtttcct cattattatc attatgaaga 3370081 aaatcatttc taggatatcc agattcaatc attgtcttgt taaactgaaa cgcccgtgta 3370141 aagatctcag ttgaataacc atttggggaa atcaagtaat cccaattaga agcttccttg 3370201 ataaaattcc ttttatattt tttggtgttt gtaccaggca tatggacttc ttccatatcc 3370261 attgcaagtc tttttaaagg tgtgccatgc catgtttgta aatatgttgt atgactaggt 3370321 ttcggaatcc ataatggaag ccggctgtta acaacccaat actcagctct tgccatagcg 3370381 aagagccatt ttaatgagag gcgattaatg taaggaattc ccttttcatc aaaaggcgct 3370441 gaatattgtt tatttacact ccaatacatt ttatactcag ggtggttttc ccgcatatat 3370501 tcgtaaatcg ctctcggatt acaactgtat tgtttcccat taaaactttc aaaaatgact 3370561 gttttccttt taactggcat tctgctagcc atcatgaata gagatttgta tgttttagtg 3370621 attaacttgt ttctcatttt tgtgatcttt tttatttttg atactaatct cttcttcttt 3370681 cctttaataa agtatttcat ccttgttttc aggctatagt cgtttactct gatacctaga 3370741 gtctgctttt tctttttctt aaagacttca taacgaactg gtgcgttgtt tgttttaata 3370801 atacttacta atccttttaa tttgtttttt cgatctccta aaacaagagc agtgctgttg 3370861 aactgaatat ccgttccttc atcgtcattg catatatact ccataaaaag acgataaaca 3370921 taacgttttt catttgagaa aggaatttct ttcaaaggca ctttcacttc aaaatcatac 3370981 agttccggaa caaaaccatc tgctctcatg ttttccaggc catgtgtttt tctttctagc 3371041 ttgattggaa atttttcctc aataggtgtt tctccaccct tttttaaaat aaggttcaag 3371101 ttttttatcc gatattgatt ttcggaactc aggtaccccg cataacctgt tatgcttatt 3371161 tcttcagagc taatctcgat ttgatcaaat ctgatgattt tggcctctct tttcacctta 3371221 atagaaaagt tgcctttatc agttgtataa ggtaaaatca aaagttctgt ggtttgatcg 3371281 acatgaaagg cgcgctcaat tgaatttact tcagcagaaa gacgcttcaa gagtggttcc 3371341 tgctccgcat cttcatattt ttttcgaaat tcgacataaa aatcatatgt ttgtcccatt 3371401 tcaacaggca taggcaaaac atgagcattt atctcagttt tatactctaa tgagccagtg 3371461 ttttgaagcg gaaattcaga ttccgttcct gaacgtctct ctttcagctt taaaaataac 3371521 tggtaatcct ctaaaaattg gtgttctgaa tcaattgaga ttaacaattc aagacttcct 3371581 aaattgtttt tcaagctttt caaaatacat ttaatcacag tgttttcaat cattactttt 3371641 ttctgctcct ctgtataaaa gctctttcct ttttgcttcc ttttattagt gtcaactact 3371701 aaggacatta actctctttt atttccgtga ccctccaaga gaaattgcct ttaactgttg 3371761 tatagggctc tactctatag ccattattag tatctatact gtttcctgac aattttgttt 3371821 cttcactcga aagtcttcgc attgttttaa tatggccatt tgcattgaaa acaatataaa 3371881 aatcaataac ttgggtttta ttagcagcta tcttttcaat atttacatct ttttcgagat 3371941 caattacaaa cagttgatca ttttgtaagt ttgttgaaat aatttcagcc ttattctttc 3372001 tgtccaagcc cactaaacgt atttttttaa tatcattatg atcaaaattc tcaatgtcaa 3372061 tttctatttt agttttatca aaatcctcag tataggaact aatagaagga tctttttttc 3372121 caaccttttt agagaacttc tctctttcta ttcgcacctc aatcatctga ttaagagcaa 3372181 aagcccaatt ttcaatatag ttgggtcttg aatatttttc agccatttta aaagcttgtt 3372241 ctgaaaattt ttgatgagta ctttcatctt tcatcaaaga gataatagct tgacccaatt 3372301 tctctatatt atactgttca atgacatatc catttgctcc gtcagtaact aagctccttg 3372361 ctccgtaatc ataatcgtat gttacaactg gacatccatt gctcagtgcc tccatatttg 3372421 atagaccgaa cccttcaaaa tgagaggttg aaatggttag ccaagctttt tgaaactctg 3372481 agtcagggtt atccgtatag cctttcaaaa agacattgtt ctgcagtttg gtatcttcaa 3372541 tttctttttt tattttttcg aaatcttcac ccgatccgaa tatatcaagt tttgcttcag 3372601 gaatttcttt cacgactaaa ctaaatgctt ttactgcatg tatcagattt ttcatagatg 3372661 caagtcttga aataatgaca gctttgtatt tttcactcgg cacattcaat acagcgggat 3372721 caagaggctt atcaattgta tgcggagtaa agaaaaacgt ctcttgttcc cctgaaatca 3372781 atttaaaatc ttctagctgc tcctcagtta taaaaaagac agcatccaaa ttatacatct 3372841 gactaaatac ttctttatag cgacccttaa tttgatattt attgctgccg taatgcttgt 3372901 tatgaataat tgctccataa taggaagaag gtgatttttt cactttaaag acatgtttgt 3372961 cttgcggtct gctgtccact aaaaacaact taggtttatc attttgtttt tgcagatatt 3373021 ctatccaata ttgacgcagt tccgattcat cttttacttt tatctcaccc tcaagggagt 3373081 accaaataat atgagataat tgaacatctt tttcttcatt gttccataca tagagtttgt 3373141 ctaaatatac ttgattttgg tcattaatat attcctgcag atacatcttg tttagctgca 3373201 catcataatg agtaacgaga actaagtttc cgttcttcgt atattcctct ctctttatga 3373261 gctggttttt atcattccaa tagtcgacgt accggatagt ttctccatct ccgtagtaaa 3373321 ctacagacat ttcattgttc ttcttaccaa acaatctcaa cagagttttt gcaaatttcc 3373381 ccattccaac ttgctttttt atctggtcaa ggcctatcct ttcttcgtat gatcttttcc 3373441 catttgttct aacacttaaa aaatcatcga atagattaat aacacttgtg aattttttat 3373501 caatcttacc gttgctgtac aattcatcaa tttttgaaga caactctaaa tcaaaacgaa 3373561 acgttaagaa aaaggtgttt tggttacact cttctccaaa taattttgaa cgcaataata 3373621 atgatttcgt cagaccgcca taattacttg gcagtccacc agagataaaa taataatcca 3373681 tgtcaggaat ttgttttata ttagattcac tcaccgcatg taaagacaat tttttactcc 3373741 ctttcggcat ctagaatata tgatcattga aatttatatc tacccggata ctttagtcac 3373801 aaaaatcaat gtaagcatca aaaagtactt cttatttcaa taagaagtac tttaattaga 3373861 tattgaacca atgatatcag gatcctaaat tataaaccag caatttcctc tttgatcttt 3373921 gttgtagaga tgccttctgt tcttgggagg taaacaacct cacactgatc tttgagaaag 3373981 tcaaatttac cttcccagtc atcccccata acaaaaacat caatattatg atcaataata 3374041 tcttgctttt tttgctccca attcttttca ggaattactt cgtccacata tcgaatggtt 3374101 tctaaaatta atttacggtg ctcatagctg tgataagctt ttttttgctt ttgtaaattg 3374161 aattcatccg ttgaaatagc aacaactaaa taatcaccaa gctgctttgc acgctcaagc 3374221 aatttaatgt gaccccaatg cagtaaatca aaagttccat atgtgataac ttttttcatt 3374281 taaagaaacg ctccttccta atgttaaaca ctattaaaaa cactactgac gttagcgatt 3374341 aaattctaaa aacctgtttg tattccttat atcgacatat ttctcgtatg tcttcactga 3374401 tcattaatta tagcataccg cctaaaaaag gttaagtact catgaggaga aaaacattcc 3374461 aaaatatgta attacactca gactccattg gcaccaaggt ctgttgttca ttcgttcatt 3374521 caattgtaaa attggaaaca tatttaaatt taatgtaaag ataatgttaa tcctttgttg 3374581 aagatttatg ttaaaatata aggtagcttg attttgcttt tagaaactct cggtttttaa 3374641 ctatataaat agaatcttaa aggaaggagg agccagacat gcaaacagag actattcaca 3374701 atattcctta tgttaacagt aacttaacat catttatcga ttacctagag aaacattata 3374761 ttgatcaaaa gattggtgct gtcatttcca cagtcaaccc tgaaattgca tttgcagcta 3374821 ttaaagatcg ggactacttt gatgtactat cttcttcaaa cttcattttg cctgatggga 3374881 tcggtgtagt catgatgtca cgtttgacta acaacaggct tcagtcccga atcgcaggtt 3374941 acgatgtttt taaagaactt ctgggcgttg ctaacaaaaa gaaaaaacgc atatttctgt 3375001 acggtgcgaa gaaagatgtt ataaaaggtg ttgtatccaa aatttcttct gaatacccaa 3375061 acattaaaat cgcaggttat tcagacggtt atgttcaaga tcgcacccta gtggcaaaac 3375121 aaattgcaag agcaaatcct gacatggtat tcgtagcttt agggtatcct catcaagaga 3375181 aattcattca taactacaga cacttgttcc ctaaagccgt atctataggt ctaggaggaa 3375241 gctttgatgt atttagcggt aatgtcaaac gggccccttc ctggatgata cgtttaaatt 3375301 tagaatggtt ctaccggtta atcttgaatc catggcgatg gaaaagaatg cttagcatcc 3375361 caaaatatgc tttaacggtt ttaaaagaag aaaaaaacaa aaaaactttc tatccaaagc 3375421 ctgaaaaaga tcatacaaaa cagatttaaa aacaaaactt tcaaataaat ggatgataaa 3375481 aatgaaaata agatcactac tggcgaattg ctatttgtat tttttatcag caatcgcctt 3375541 ttttctgcaa tgggtgaaac ctgaaagcaa agtgaccctc ctgatctcat tcgaagcaaa 3375601 cgcaaaagcg attcttgagg aatatgaaca aggacaatac tcttataaac ttaacatcct 3375661 gtatacccag caggcctctg ctattgccga gagcttcccg aatgtagatg catatttatt 3375721 acaagaaaaa aaccctatcc atctcattaa agctgtatac ctaatgttta acagtaaagt 3375781 gatcataaca gataattact ttctattaac aagtgtgtta aataagcgga agcaaacgaa 3375841 atgtatccaa gtatggcacg caaatggctc actcaaaaaa tttggtttgg aagacattac 3375901 aaacatgcaa cggacgaaaa ctgatattaa aaggttccaa aaagtataca gttcgtatga 3375961 ttatttaact gttggctcag aagagatggc aaatatcttc aagaaatcat ttggaataaa 3376021 ggataaccaa ttattaaaaa taggtgtacc tttaacagac ccttattacc gagaaaacaa 3376081 gaaaaaaatt tcagatactc taaacataca aagaaaaaaa ataatcctct atgcaccgac 3376141 gtttagagat tataatatgc aatcaattca attgcctttt acagaagaac aattaattca 3376201 tcagttaaaa gaagaatatg ttttatttgt taagctgcat cccgccattc agaacaatat 3376261 tgatattaaa tattccagtg attatattaa agatgtttct aactatgcct tgtttgatct 3376321 actcatggct gcagacatat taatcactga ctattcttct gttccctttg aattttcgat 3376381 tttaaataaa cccattcttt tttatactta cgatttaaaa ctttatcaac agaagcgggg 3376441 attggttgat aattatcttt ccataatacc tggaagagcc tgctatgaca gtgaatcatt 3376501 aataaatgaa attcaaaccc catttaatta ttccaaaata aaagtttttt ccgatagatg 3376561 gaataagtat tctgatggga attcaagcca aaatttattg aatttcatcg aaaatttaat 3376621 aagctaaatg atgacacttg ttcaaaacag aacaagtgtt cttttttcta ttgaataccg 3376681 aacgtatgtt tgctttaatg taattagttg cttatggcag caaataataa tagaggtggt 3376741 aaatttatga gaaaaaaaga actgtttgat ttcaccaaca tcacgccaaa attatttact 3376801 gaactacgtg tagcagacaa aaccgtactt caatcattca atttcgatga gaaaaaccac 3376861 caaatttata caacccaagt cgcaagtgga ttaggaaaag acaacaccca aagctatcgc 3376921 ataactcgtc tatctcttga aggtttacaa ttagacagca tgctgttgaa acatggaggt 3376981 catggtacaa atattggaat tgaaaaccgt aatggcacca tttatatttg gtctctatac 3377041 gataaaccaa acgaaacaga taaaagtgaa ttagtttgtt tcccatataa agcaggcgcg 3377101 actttagatg aaaattctaa agaacttcag cgattctcga atatgccttt cgatcatagg 3377161 gttacacctg ctcttgatat gaagaataga cagttggcaa ttagacaata cgatacaaaa 3377221 aataataata ataaacagtg ggtgacaatc tttaacctgg acgatgcaat agcaaataaa 3377281 aacaatcctc tttatactat taacattcct gacgaacttc attatttaca aggtttcttt 3377341 ttagatgacg gttatttata ttggtataca ggagatacaa acagcaaaag ctatccgaat 3377401 ctcataactg tatttgattc cgataataaa atagtgctgc aaaaagaaat tactgttggc 3377461 aaagacttgt ccaccagata tgagaataac ttccgtgaac cggaagggat ctgtatgtac 3377521 accaatcctg aaactggggc aaaatcatta atggtgggaa ttacaagtgg aaaagaagga 3377581 aatcgtataa gcagaattta tgcataccat tcttatgaaa acttcatgaa tcatgtacct 3377641 atgcttcgat cccctttatt aaaaaccgtg gggcaccaag atacacctcc agaaagattt 3377701 caaccattta ttcaaacctt cattttagag tataatgctc aaaacaaaaa atggatggtt 3377761 ccgacttcag gttatttacc atcttacaca tcaaatttag tccgaaatat tactatcaat 3377821 gcagatggaa acttgcaagt cacattaaat gaacgctata ttagtttact gcatcaatcg 3377881 atagaaggag atttccgctt aaaacaaaag gatatccgaa tgggatcctg gtattttgcc 3377941 ggcggagaaa aatcaaatgt gcttgaaata ggttttatga aagggagtac aaaaatcaga 3378001 cccgatgatg cagccatctc aaatgcttca agaatgagta tttttatgat tgttgcggac 3378061 aagattgagg tgtgataatc aaataggctg tagctattta atagctacag cctatttgca 3378121 actttctaag ttttttatcg atattccgga acatcaaaat aaagtgtata accgtccagc 3378181 aatgaataca ggctgtacat gcggtttact tgtttgtacg cccagccgat gtctgttgcg 3378241 tattgatgtg tcgctgtagc tgaccatctc attttgtaca gtgtgtcttg attgtaagct 3378301 gtgttgtgga tatacgatga gcctatgaat ttagctccgc cgataatggc cgcttctggt 3378361 gtgaaccagc cctgctcgta cgcatatttg gctccgtagt aattcggatt gctgtcgtat 3378421 gctccaattc catacatgtt gtatacggtt tttccgttat aggttaatcc attggctaaa 3378481 gcggatgtcc cgtttcctgt ttccagaaga gcgtgtgaga ttaaatacag ttcgttgatg 3378541 ctatattgat tggcggcatc gataaatgcc tttgctctcc ctgtcaggat gcctttaccc 3378601 gcaagcactt tctgatttac ctcagtaacg ctgagacccg ctgtctgtga cagcttgaga 3378661 aattggaagt agtatttgct gtctctggaa aagttattcg gatccacgta ttgaactact 3378721 tcatcactgc ttgcgtttcg ccagcccaaa ttgatcttag cccagccgtt tatctgtccg 3378781 atgactttca ctttatcgcc ttttttaaac tggccgatca cgtttgtcgg gctgacttcc 3378841 ggcgttgacc ggatatttag tacatcagcc gtaacagttg atgttgctgt attaatgtac 3378901 gtgagcgata cgtaagccgc tccgtctgtt tgcggactta ctgtcatttg tttttggacc 3378961 atatcacgaa gcgagagatt gtagtttgtt ttcatgattt gcgggccgtt tttgatcttc 3379021 acgatagatg atgtccatcc gtataattgt tttagcttcg ttgatgccgc agcagctgta 3379081 tcattgcctg tgaactgctc atttacgctg attttataaa gcgtattgct tttcgttgta 3379141 tagctcgggg ttacactttt cgatttaaga taggttaacc cattgttcaa tgcggttttg 3379201 ctgctaagct gtgttgtcac gattttgtat tgtgtatatg cagtctggcc tgtttttgat 3379261 gttgtgactg cgatatgatt ttgtttgaaa aatgttaaaa cgcggtcaat ctcttcttgg 3379321 ctgatgatag cttcagttgt gatttgatag ctgctcgcag ctgtctgacc ggttttctgg 3379381 cttgctactg atatatgatt cgatttgaaa aacgtgagtg cctgattgac tttcgtttga 3379441 tcaagcagag attcggttgt gattttaaac gtgtcagcta tttgtttttt gacggatttc 3379501 gcagaagcac ttagctgatt tttctttaat atgttcaaac cctttgtgac ttttgcttga 3379561 tctgatgttt cttctgagat gagctgatat tgattttctg ctgttgatcc agctgctgtt 3379621 tttgcagctt ttactttttt ctgagcaaag aaggctgctg ctttgtttgc ttgctgctcg 3379681 cctaaaatct ttgccgtcgt gatttgataa gctgcagacg ttgtcgtttt tttgacgctg 3379741 gatgacgtgt aatgccattt tttcttttta aagaaagtgt ctattttttg gagctgctgt 3379801 tttgttatac ccttcatatt cacggtatat gatgtgcttt ttccaacctg ttgataactg 3379861 ccggatacgc cagtgttttt cttgatttgg ctgatggcgt cctttactgt actcagccct 3379921 ttgaaataag ctgattggac attgtatgac tcaacggttg ttttttgatt gatggacttg 3379981 tagctgcctg tgatgccagt gctctgtttc agctgctgca atagagtttt ggcattggct 3380041 tcacctgaaa tggcggcagt tgtgaacgta taataggctt gccctttcac tgtttccttt 3380101 aatgatgcct gcagcccaga ttccttttgg aaggcgtttt tgatctgcgc tgctctgctg 3380161 tctcccacga ttgtgccaga ctgaatggtt gtgacagaca ccgtgtgtgt gatgggctga 3380221 tacgagcttt taatccccgt ttgcttggcc aggctctgga taagcgcctt gacttttgtc 3380281 tcatcagcaa tgtctgatgt catgacgttc atatagggct gagctgctcc gtaagctttt 3380341 acagcgccag ccactcccgt ctcctgtttc agctttgcta ggatagtgtt ggcctgtttt 3380401 tctccggaga tggcacctga cgagatggtg acatatggct gtttgcttcc aacaggactt 3380461 gacgttcctg taattgatgt ctgtttggcg agtccgctca gtattgcttt cgcttctgat 3380521 tcgctatgaa tgcctgaggc ggaaatttgg taggtcgttg ttgtgcctga agcctgatag 3380581 gatgcatccc agccagtatc tttttccagt ttggcgacag cttgtgaggc ttggctttct 3380641 gtactgaacg tattcgacgg ctctacttta tatagtgagt agtcggtata cgcggctgcc 3380701 tgggcagaac cagacatggc aaaaaaggca agggacgcgg cggatagaag cataggtgcg 3380761 attagtctct ttttcattcc ttctcctctt tcttattcta tgagtatata aaactagttt 3380821 atttatcggc acgcgcatgc ttcatttata ggtgaatcac ttccattttc taataaaaaa 3380881 acttaacctc gaagtgagat taagtttaaa tatgagacac gataagggta caagttcctt 3380941 ttatcgtaaa atcgggcatt tgagccggca aaataaagtg atcacctttt ttgagcggac 3381001 atgttttgtc ctcatacttg agcaaaccgc ttccttctat cacgctgcaa atcagaaagg 3381061 attcatcctg agccatttca gcttcgccat tgatgtccca tttataaacc gaaaaatatt 3381121 ccccttggac aaatgtttta atggttattc cttttcttga ttctgtcgat tcatctatat 3381181 acccgtccac atggggaacc gtggcggcat tgaccgcttt ggcaaaatga agctctctcg 3381241 gacttccgtt gctatcaaga cggtcataat cgtacacccg gtatgtggca tctgaatttt 3381301 gctgagtctc taaaacaagg gcccccttgc acaatgcgtg cagcgttccg ctcggcacat 3381361 aatagaaatc acccggttta attttgattc ttcgcagcag gccctcccag tcaccgctgt 3381421 tgatcattgt gacaagttcg gtttttgagc gggccgtatg cccgtaaatg atttctgcgt 3381481 tttccttaca gtcgataatg taccagcatt ccgtcttgcc gagttctccc tcttcgtttt 3381541 ctccggcata gtaatcatca gggtgaactt taattgacgt atcttccttc acatccagca 3381601 gctttgtcag aagcggaaac cgatccccct ctacgccgcc gaatacttca cggtgctctt 3381661 cccaaagctc gatcaatgtc tttcctttat acgggccatt tgcaacagtg ctcggtcctt 3381721 ttggatgagc ggaaatggcc cagcattccc ccgttgattc tgaaggaata ctgtatccaa 3381781 atctatctcg taaagcggtt ccgccccaga ttttttcttt aaacacaggc gttagaaaaa 3381841 tcggtgattg cgtcatgatc cgtacccctc ccctgtaaat aactgatcat cattttcccg 3381901 gtgcgcccct cttacaaacg cccgtataag ctgccttttt cctatgacaa catatgtaca 3381961 aagcatcatc ttttcattac cccttcaaag aaaacgcttc ctatctatta tatcacgtcg 3382021 aaaagaagct ttgtttcagc cttttcctcg ataagaataa ttctcctttt ttgatacaaa 3382081 ttaataaaaa ccgtcaatat gtttaagaag gagagaaact atgcaaatcg actctgatct 3382141 ccagaacaat ttagacacac tgaaaaaaac attgggacaa aacgacgata tgatgtttta 3382201 tacatttgct ttcggagata gcagacaaaa ggcgtgttta ctgtatattg acggtctgac 3382261 agagaataaa atgctggcgc aatacgtcat ttctccttta caaaaagagg cgttggccca 3382321 taaggaatgc tcgattgaag acttatccgc cttttttttc ggctttcacc acagcgttgt 3382381 ttctacaatg aaagaaatag agcagctcgt tttttcaggg caagccattt tgctcgctga 3382441 tggctatcgc ggaggattag ctttcgacac aaagtcagtc gcaacacgca gtcttgatga 3382501 accctcctcc gaagtcgtgg aacgcggccc taaaatagga tttattgaaa agctgcggac 3382561 aaacacggcg cttttgcgtg aacggacgag tgatcctaat ctcgtcatca aagaaatgac 3382621 actcggaaaa aggaccaaaa agaaaatcgc tgtcgcttat attcaggata tcgccccaga 3382681 ttatgtcgtc aaagaagtgt ttaaaaggct gaaatcagtc aatatagata atttgccgga 3382741 atcggggacg cttgaacagc tgattgaaga cgaaccattt tcaattttcc ccacaatatt 3382801 aagcacagaa cgaccggacc gggtcgaaag ttctctatta gaagggcgag tgtccatatt 3382861 agtggatggt acgccgtttg ctttgattgt accggctacg gttgacgaat ttattcattc 3382921 gcccgatgat tacagccagc gctggatccc aatgtcactt gtacgccttc ttcgttattc 3382981 cagcatcctg atcaccattt atttgcccgg tctgtatatt tctctcgttt cttttcacac 3383041 cgggctattg ccgactagaa tggccatttc cattgcaggc agcaggctta acgtaccatt 3383101 cccgcctttt gtagaggcct ttatcatgat ctttacgatc gaattgattc gagaagccgg 3383161 attaaggctg cctaagccga ttggacagac aattggcctt atcggcggcg ttgtcatcgg 3383221 acaggcagct gttcaggcgc aaattgtcag tgcgcttatg gtcattgtcg tttctgtcac 3383281 agcactggca tcctttaccg ttccttcata cgcctataac tttccgctgc ggatcattcg 3383341 gatcggggtt atgataagtg caacagcgct tggcatgtac ggcgttataa tggtttatct 3383401 gtttgtgatc ggccatctca tgcgcctgaa aagctttggc caggattaca ttatcccgat 3383461 catggcgcag cctggacagg atttgaaaga cacagtcatc cgtattccca cgatgttttt 3383521 aaaaagaaga ccgacacgaa acgatcccga agataacatc agacaaaggt gatggctatg 3383581 aggaaatcag agcataaact gacatttatg cagacgctca ttatgatcag cagcacattg 3383641 attggtgccg gggtgctgac ccttccccgc tcagccgccg aaaccggcag tccgagcgga 3383701 tggctaatga tactgctcca gggcgttatt tttattatca tcgttctgct ttttttgcct 3383761 tttcttcaaa aaaacagcgg aaaaactctt tttaagctca acagcattgt agctggaaaa 3383821 ttcatcggct ttctattgaa tttatatatc tgtctatatt tcattgggat tgtttgcttt 3383881 caagctcgga ttttgggaga ggttgtcgga ttctttttgt tgaaaaatac gccaatggca 3383941 gttgtggtgt ttatatttct tgcagttgcc atctatcatg taggcggagg cgtttattca 3384001 attgcaaaag tatacgctta tatttttcct ataaccctta ttatttttat gatgcttctg 3384061 atgttcagct ttcgcttgtt ccagcttgat tttatccggc cggtatttga aggaggctat 3384121 caaagctttt tctctttatt cccaaaaaca ttattatatt tctccggatt tgaaatcatt 3384181 ttttacctgg tcccctttat gagagatcca aagcaagtga aaaaggctgt tgctctgggc 3384241 atcgcgactt ccacattgtt ctacagcatt actttgctca ttgtgattgg ctgtatgact 3384301 gtggctgagg caaaaacggt gacatggccg accatttccc ttattcacgc attagaggtt 3384361 ccgggtattt ttattgaacg atttgatttg ttcttacagc tgacctggac agcccagcaa 3384421 tttgcctgta tgctcggatc ctttaaaggc gcccatatcg ggttaacgga aatctttcat 3384481 ctaaaaaata aaaacaatgc atggctgctg actgcaatgc tggctgcgac gtttttcata 3384541 acgatgtatc ccaaggactt gaatgacgtg ttttattacg ggacgcttct tggatatgct 3384601 ttcttaattg tgattacaat tccattcttc gtctggtttt taagctggat acagaaaaaa 3384661 atagggaggg ggcagctgca atgaaaacag catcaaaatt ctccgtcatg ttttttatgc 3384721 tgctggccct ctgcggctgc tgggatgtca aagatatcga gcaactatcc ttcgccagag 3384781 ggctggcgat cgatgagaca aatgatcacc agtacaaact gacgtatcaa aatcttcttc 3384841 cccaaagcga agacagccaa gcatccggaa aacccgaatt tgttaatgta acgtcccacg 3384901 ggaaaacgat tctggaagca gtcagtgatg tatccatcaa ggaccctcct gtttatagcg 3384961 atcatttaaa agtgatcctt ctgggagaaa aactgatgag gaatcaaaat gtagaccaag 3385021 tcctcaacca ctttatccgg gatgatgagc tgcggcgaag cagctatttg atggcagcca 3385081 gagggaatgc agctgatgtt ttcacaaaag gaaaccccaa tcagcagcag ccgatgccct 3385141 ccgaaaaact gattgatttg acaactcaca gcggatataa cggtaagatt atgataccgc 3385201 tgcgcatcgg aagagcttct gtctactctc agaacgggta cagttatctt attcaagccg 3385261 tgaaaaacga aaagggaaaa gccaagtatg acggagcagg cattatcaaa aggggcagca 3385321 ataaactcgt tgggtttctt tcagctgatg aaacccaaac actgtcatgg gtcatgggga 3385381 cgatccaagg cggtgtcatg ccgacgacag ataaaggaca tccgattacg tttgaaatta 3385441 aaaagtcgaa aacgaaaatt aagcccgtca ttgaaaacgg aaagcctgtc tttcatattt 3385501 ctgttaaaac gaagggcatc ctgacagaag accaaaaccc gaatgaaaac tcctttagca 3385561 aaagttattt gcacaggctg gaaaacattt ttgaaaaaaa gcttgaacga gatgtaaagc 3385621 aggtgatgga taaactgcag cacgagtata aaaccgatcc ggtcttttta tcagaccaca 3385681 taaggattca acaccctgac tactggaata aagtaaaagg gcattgggat gaaatatttt 3385741 ctgagactga ttttaagtac gatatttctt ttaaaatcat taactttggc acggtgggaa 3385801 agtaagcaat caaaagggtg cgcatgatcg cgcacccttt tttatgttcc gacagtctgc 3385861 tgttttccgg ccgctcctcc ctgtccgttt ttgtcccgta aatcctgctc aatttcttca 3385921 aggcttcttc cctttgtctc tgtcacttta aatcggacaa ataagaacgc catgataccg 3385981 atcgcggcat aaatcaggaa taaataactg attccgatcg cttccattaa tattggatag 3386041 gttaatgaaa caatcagtgt cccaacgtgc aacattaagg tcgaaacacc ggtcccgatt 3386101 cctctgacgt gaagcgggaa caattcagga agcatcaccc acacaaccgg tccccagctg 3386161 accgcaaaga caacgataaa cacgcctaaa caaatgacgg tcgtccatga ggcagccgga 3386221 gtgttatcga aaaagagatt tactaaagcg agaacgatca agctgatcac catgcccgca 3386281 ttcccgaata gcagtaacgg ctttcttcca atcttgtcga tgattttaat cgctactaat 3386341 gtcatgagaa cattgactgt gccgattccg accgtgccta aaatcgaagc ggagtttccg 3386401 aatccgacgt ttgtaaaggt ctttggcgca tagtagatga tcgtattcgt tccgataaat 3386461 tgctgcaaaa aagcgagtcc caaacctgca ataagcgctg ggcgcaccca tggatcgaac 3386521 agctccttca gaccgccttc atcctgcttt tccgcttctt ttatatcatg tatttcctga 3386581 tcaatatctt ttgtgccacg caatttttca agaattttct tcgctttgct ttcttcgcca 3386641 ttcgtgaaca gccagcgcgg gctctccggc ataaacaaaa tgccaataag caagagcaat 3386701 gacggcacag cagccaatcc aagcatccag cgccacgctt cggcatcggc aaatatgtaa 3386761 ttgacaatgt aagaaagaag gatgccgacc gtgatcatca gctgattcag tgatgacagc 3386821 gccccgcgtt tatgttttgg cgccagttca gataaataaa ggggtacgat tgtcgtcgat 3386881 gttccgactg caagtcccaa aatgatgcga aacagcacca tgactcctgt atttggggcc 3386941 agtgccacac caagaccgcc tatacaaaac agcagcgcgg ctgccataat tgcttttttt 3387001 cttccgaaac ggtcagtcag cttgccggcc gctcctgagc ccaatatcgc cccaaccagc 3387061 aaggagctga caacaagacc ttctgtaaac gcgtttaagc ctaactcctt tttcataaat 3387121 aaaatagctc cggaaatcac tccggtatca tagccatata acgcgcctcc aagagctccg 3387181 aaaaaataaa gccatatatt tgactgcttt ttcataaaga tgactccctt tctccatcag 3387241 ctgcaatgac attgtctgtg ggattttttt agaaatcttt tagcctcttt ttccggccat 3387301 taaacctttt tatttttctg atcataagtt ttccaatcat ttacttgtat ttttttcaat 3387361 gtcgccgaaa cattttacct gctgcggcgt ccaatataag gtgattcagt acattatcgt 3387421 tatcaatttt caaaaacaag aacttataaa tataggaata tttatcgaaa aatgtctttc 3387481 gagtagttgc cccatggcaa atagaatggt acgcttcaaa tattaaagaa acgtgaggta 3387541 ttgatatatg gaagaacgat cacagcgcag aaagaaaaaa agaaaactaa aaaaatgggt 3387601 gaaagttgtt gccggattaa tggctttttt agtcattgcg gcaggctctg tcggcgccta 3387661 tgcttttgta aagctgaaca atgcttctaa ggaagctcat gtcagccttg cacgcggaga 3387721 acaatctgta aaacggatca aagaatttga tcctggaaaa gattcttttt ctgtattgct 3387781 cttaggaatt gatgccaggg agaaaaacgg cgagaccgtc gatcaggcaa gaagtgacgc 3387841 gaatgtgctg gttacattta atcggaaaga aaaaacagct aaaatgctga gcattccgcg 3387901 tgacgcctat gtaaacatcc caggccacgg gtatgataaa ttcacacatg ctcacgctta 3387961 cggcggcgtt gacttaactg tgaaaacagt tgaagaaatg ctggatattc cagtcgatta 3388021 tgtcgtagaa agcaatttca cggcttttga agacgtcgta aacgagttaa atggcgtcaa 3388081 agtaactgta aaaagcgata aagtcattca gcaaatcaaa aaagatacaa aaggtaaagt 3388141 cgttcttcaa aaaggaacac atacgcttga tggggaagaa gcgctcgctt acgtaagaac 3388201 acgtaaagcg gacagtgacc ttttacgcgg gcaaagacaa atggaagtgc tgagcgccat 3388261 tatagataaa tcaaaatcat tgagctcaat tccggcttat gatgatattg tggatacgat 3388321 ggggcaaaat ttaaaaatga acttatctct taaagatgcc atcggcctgt tcccgttcat 3388381 cacttcattg aaatcagttg agtctattca gctgacgggt tatgattatg aacctgccgg 3388441 agtctattat ttcaaattga atcagcaaaa gctgcaggaa gttaaaaaag agctgcaaaa 3388501 cgatttaggt gtataatgaa cgggatggcg attacgccat cccgttttac atatttcctt 3388561 gttgaaaatt atcaaagtaa cgtttagcct taatttatat ggattatgtt tcacaggcaa 3388621 gctgaacata ctacacgaag cagcttcatt tttaaggagg ttcccctaca tatgaaatgt 3388681 attgcgattg atctagacgg aacattactg aataaagaaa gcgtcatttc tgcggaaaac 3388741 agagaggcga tcaagcgggc cgttgatgcc ggcatcctcg tcaccatttg cacgggaaga 3388801 gcgacatttg atgtaaaagc gctgctggat gacttggaca tccctatcat tgcagctaat 3388861 ggcggtacga tccacgacac gggttaccgt ttgatcagcc ggacattaat ggatcaggaa 3388921 gccggtaaag cgattgctga ttacttactt tcaaaaaaca tttactttga ggtatataca 3388981 gatgaccatc tgctttctcc ttttgacggc gaagctaagc tgcacgcgga gcttgacatt 3389041 ctaaagagcg caaacccaaa cgagcagacg gatgacttgt ggcaaggagc catgactcaa 3389101 ttcaaacagt ttggcattaa accaatccct catatcgaat cggtttttga cggcggtgaa 3389161 aacatttata agcttctttg cttctccttt gatatggaca agctgaaaca agcgaaggaa 3389221 gaactgaagc atcataaaaa actggcgcaa acctcttcag gaaaacatat tatcgaaatc 3389281 ctgccggcct cgtcaggaaa aggacgcgcg ttaacaaagc tggctgacat atacggaatt 3389341 gaaacacagg atatctatgc gatcggcgat agtccaaacg atttgtccat gtttgaagtc 3389401 gccggacacc gtatcgccat ggaaaatgcg attgatgaat taaaagaaaa aagcaccttt 3389461 gtcacaaaaa gcaatgacga aaatggtgtg gcctacttta tagaccagct tctttcgggg 3389521 caatatgcat aaagaaaaga ctccagagat tggagtcttt ttcttttatt gcacccgtat 3389581 acttcctgcg tatttatcct tccaatatgt gctcgtgttc atattggtaa tggtcacgcc 3389641 gtttgataat gtgacatgaa caacttgtcc gtttccgata tagatggagg gatttaagct 3389701 tgttgattga aagaacacaa tgtctcccgg cttcaggtcc gccttctcaa tcttagttcc 3389761 ggcattgtac tggcttgttg cgtatcgagg cagggaaata ccggctgctt tctggtatac 3389821 atattggaca aatccagctg tatcaaatcc cgtctcaggt gttactccgc cctgtttgta 3389881 aggcacttct ccgacataaa gcgtcgcttc ggaaacaatc ggattttctt tcgggattgt 3389941 caggttgtca aatcggcgaa tacccgtcat cttcgatttc cagtaatcct ctgacaaata 3390001 ggaaatggtt actttttctg accggcttgc ctgaatgaac ctgcctgcgc ccgcataaat 3390061 gcctgcatgt gaaattcccg ttttatacgt attgctgaaa tagacgacat caccaggctt 3390121 tatgttctga ggggctacct tctcgcccac tgcccactgc tgttcggctg atcgcggtag 3390181 ataaatgccg agtgcctgtt gaaacacata ttgcacaagc cccgagcaat caaagccctc 3390241 tgacggcgtg cttccgccaa acacatatgg gacaccgata tatttttcgg cctcctgaac 3390301 gacaggaaca tcagccgttg ccggatcggc agcgattcgt ctcgccccga tataagttcc 3390361 gctccaatag ctgctttttt tgtaattggt gatgataacc ccttttgact gtgtactgtg 3390421 aaccatttgg ccgtctccga tataaagggc gtcatgtgtc ggaacagtgc cggtgcttcc 3390481 ctctttcttg aaaaacaaaa tatcacccgg cttcaggttt tccggtttta cagctgttcc 3390541 gattttatac tggtcgttta cagatctcgg cagatgaata tcagccttac tgaacacata 3390601 ttgtatcaat cctgatggat cgaaaccctc tttcggcgtt tccccgccat atttatactg 3390661 atatccaagc aggttttttg cttcgctgac aatcaattct gatgatgtat cagcttccgc 3390721 aatctccgct tttgtcataa ttggaaccaa aaaacaaatg ataaccgcca caagcaaaaa 3390781 cttcttccag tttgccagtg tgttcacttt tattatctcc tcctcttttt gcagttttaa 3390841 catcggtatt tttttgaata tgttaagaga ctttttaata tttttacaga atgaatatgc 3390901 tgggcaaata aaaagagagt gtctcatcag acactctctt ttttgaatta tttattggcg 3390961 tttaccggtt cttcctgctg ctggatttta ttcatttcca tatcaatctt ctgtttttcc 3391021 tgatctgtca gctgatcatt gaatttaaaa gctgacataa acatgaacac gatggctacg 3391081 gcaacaaacg gccagatggc tttgacaaat ttcatcttta tcactccgat tatttagatt 3391141 ttagtttgtc actatgatca atatcaaacg tcagttttcc gtcttctact ttccaagcga 3391201 aattagagtc tttcgtcagt tcgcgaataa tggttttctg tttaaggctg tcttttttca 3391261 caggcgcagg tgtcgcttca tggatatcga tcggtgtcac ttcaaagcgt cctgttccat 3391321 ttttcttcag gtgatactga accagtgcac tgtctcttgt tctcgtccag ccttggtcaa 3391381 agacaaagtt gccgaggctg tagaaaatga cggttccgtt atatacttca atcggttcta 3391441 agacgtgcgg gtgatggccg acgatgatgt cagctcccgc atcagacatg gctcttgcaa 3391501 gctggcgctg gcggtcattt ggatcattgt catactcttg tccccagtgt gactgcacaa 3391561 caacaatgtc cgcatgtttt ttcgcttctg aaatcatagg gatgaagatt tcaggatctg 3391621 cgggcagcac gcccggcgta ttctttttag ccgcgaaacc tttcccggac acatcggtaa 3391681 agccaagcgt cgcaatcgtt accccgttga ctttctggta cgaaattttc tttttcgcat 3391741 cacttaagct gtatcccgct ccaacgatat caagattttg cttcgcaaat tctccaagcg 3391801 tatctttcat gccctgaacg ccgtaatcca ttgcgtggtt gttggcgctg ttgagaaccg 3391861 tgaaattcat atccttcaag actttcactg attccttatt cgtctgcaga tgaatctctt 3391921 tatctgcttg tttataattc ttttgatagg ttaccgggtt ttcaaagttt cctgctacat 3391981 aatccgaggc tctaaagatc ggttcaacat attgaaaaat actgtctgcc cctttttgct 3392041 ccgttacttt ttcaacatag cgtcccatca taatatcgcc tacaaatgag gctgagagta 3392101 cgtcgtcaga atacgttttg accttcggcg tttccgcttt tcccgcccac atgaaagcga 3392161 acataaggac aaaaacgatc ggaatggcaa taaatacgtg cttattggtt ttcttttttt 3392221 gctgttttgt cagctttagc agcttttcat gaaagctcag ttcttttttc atcgtttgac 3392281 acaccttaca ttaaattaag tagtaaacaa acatgatagc aaaggtcgct ccgctcaata 3392341 gcagcgtgct tccgaacgta atggttaaac cttgtttctg aatggtattg gcaattaaac 3392401 ctggcacgat gatgccgatt cctcgaaatt ctgcgatttc aaatggtaca atcgggtata 3392461 gaaaatcaaa cgcgattttt aggacgatcc ctgttatcag catggcagcg aattttctgc 3392521 gtccgtacaa aatcataaat ttggataaac cgtatttcac aatgacatac gtgagcaagc 3392581 tcactagcaa aacaagtaaa ataaagaccg gctgattaaa cacaagtcct aaatatcccg 3392641 gtacaacaag tcctgccggc acgatccctg ttttttccgc aaaaattaaa ctgagtagta 3392701 cacctaaaat tagtgcgatg tataaatctg atccgaacat gtctgcattt ccccctagct 3392761 tacgagctgc tttaccttgt attcgtggat tttttcaatt aaaggctctg cggcaccatg 3392821 aatattgccg acgccatata tgacacggtt gtgcattctt ttctttaaca attccataat 3392881 ttcatctgtt gacttatact ctagatcatg cagtttgtct gcaggaattt tgccttcttc 3392941 gtaggctttt acgatcggtt ctgttgtttc accgattaag atcagttcac ttgcttcaat 3393001 ataaggcaat acgtcatttg cgaattgctg tgtccgatcg acacggtctg cgcggcagtt 3393061 catgatgatg atcggatcat cggtcgggta accgatttct tttacacgtt tccatatatt 3393121 caaagtagaa gaagcgtcgt ttgcggcaaa cccattaaca aagtgcccag gctcgctcgg 3393181 actgatcagc ggaagaattc tcattgctcc cggatctggc ggcgcattca gcattccctt 3393241 aaatgctgtt tcttcgtcaa tgccgagtgc ttgagccaca cccagcgcca gagaagcgtt 3393301 atcagggaat accatgtatt caaatttacg taaatactca tctgtaattt ttgagttatc 3393361 agcaatgatg acttttgtgt ttcgttcttt tgctttttgt ttaaagaact cggtatattc 3393421 actatctgta atgacaagat ggccattata aggaattgta gcagtaaacg cttctgcaat 3393481 ttcatcaagc gtcggcccca tgacatccat atggtcttcc aaaacattca caatgacgcc 3393541 gatattggcc tgcagaagtt cttcctgaaa gatgatttga taatctgggt taacagccat 3393601 gcattcactg acaatcgcgt tagcccctct ttctactgtt tctctcatga cttctttttg 3393661 ctctccgata ttcggcccct gaggtttccg tttaatcggc ttttcctccg gtgtgtccca 3393721 gtaaatcatt cttgcatctg ttcctgttgt ttttccaaca gtcttgtaac cggcttctat 3393781 taatattccg gttgtcagcc ttgtcacagt cgattttccg cggatgccgt taatattcac 3393841 ccgaacaggg agggcatcaa tgtttttctg atgtcgtcgt ttttctaata ttccgatgac 3393901 cagtatgaca gcacaggcta taatgagtaa ccacattgct tttcgacatc tccttctata 3393961 ttgttgtaaa ttcattcatc agtatataga atcactatga attctcaatc ggcattatgt 3394021 aacataatct tccctaatcg actaagccaa acttctcttt tgaaagagat tttataccta 3394081 caaactgttt tctatttttg gaaaacagca ggacttatac cttatcactt tttaaaaaaa 3394141 tcaaagagaa tgcgctttca tttttctcct gatatccttc tggacgtata gtcacaccct 3394201 gctgtttgta tttaatatgc atttcaaatc aatctttttt tcagcctttg ttatcaagca 3394261 tttcctgcta tcatgcgtgt ttccggttct tatgaacaca aaataatttt atcctgtttc 3394321 ttaaggacaa ggtcataatg tcatcctttc tgcatggaat aagcaatatg aggcccattc 3394381 caaaatgact aaggaggttc gagatgaaaa cgctaaacat acgagtccga attctctaac 3394441 ataattaaac attttctggg atgatagtct tttctgtttc tccccattta caggtctaaa 3394501 cgcatgactt tgaaacaatt ttaataaaac ttaatatttg ttcaagaaat cttcatccat 3394561 atttgtgaag actttgtcaa aaaaagagtg aaaaccttaa atttttcaat tatatataca 3394621 atttacaatt agatttcttt tgatattttt attgctaact tcggattgtt catgataatc 3394681 tatctatgta aacggttaca taaacaagga ggagctgttt tggctacaat taaagatgtc 3394741 gccggagcgg cgggcgtttc agttgcgacg gtttcccgca acctgaatga taacggctat 3394801 gtacacgaag aaacgcgaac gcgtgtcata gcggcgatgg cgaagctgaa ctattacccg 3394861 aatgaagtcg ccagatctct atataaaaga gaatcccgac tgatcggact tttgctcccg 3394921 gatatcacaa accctttctt cccccagctt gcccgcggtg cggaggatga attgaaccgg 3394981 gaaggctatc gccttatttt cggcaacagt gacgaggaat tgaaaaaaga acttgaatac 3395041 cttcaaacct ttaagcaaaa tcatgtcgca ggcattattg ccgcaacgaa ttacccggat 3395101 ctcgaggaat acagcggcat gaattatcca gttgtttttc tggacagaac gcttgaaggg 3395161 gctccttctg tgtccagtga cggctataca ggagtaaagt tagccgccca ggctatcatt 3395221 cacggaaaaa gccagcgcat tacgctcttg agaggacccg ctcacctgcc gaccgctcaa 3395281 gaccgattta acggcgcttt ggaaatctta aagcaggctg aagttgattt tcaggtcatt 3395341 gagacagctt cattttcaat taaagatgca caatcgatgg cgaaggagct gtttgcctct 3395401 tatccagcga cagatggtgt gatcgcgagt aatgatattc aagccgctgc cgttttacat 3395461 gaagcattgc ggcgcggaaa aaacgtgccg gaggacattc aaattatcgg ctatgatgac 3395521 attccgcaaa gcggacttct gttcccgcca ctttctacaa ttaaacagcc cgcatatgat 3395581 atggggaaag aagctgccaa actgcttttg ggtatcatta aaaaacagcc gctggcagaa 3395641 acggcaattc aaatgcctgt cacctatata ggaagaaaga cgacaagaaa ggaagattaa 3395701 gatgcgtaat atttgtgtga ttggtagctg ttctatggat ttagtggtca cctcggacaa 3395761 acgcccaaaa gccggtgaaa cggttcttgg cacgtcattt cagactgtgc cgggcggcaa 3395821 aggagcaaat caggccgttg ccgcagccag acttggggcg caagtgttta tggtcggcaa 3395881 agttggagac gatcattatg gaacagctat tttgaataat ctcaaagcta acggcgttcg 3395941 cactgattat atggaaccgg ttacacatac ggaaagcgga accgctcata ttgtgcttgc 3396001 tgaaggcgac aacagcattg tcgttgtcaa aggcgcgaac gatgacatca ccccagcgta 3396061 tgcgttaaac gcgctcgaac agattgaaaa ggtcgatatg gtgctgattc agcaggaaat 3396121 cccagaagaa acggttgatg aggtgtgcaa atactgccat tctcacgata tcccgatcat 3396181 actaaaccca gcaccggccc gcccgctcaa gcaggaaaca attgatcacg ctacctatct 3396241 gacgccgaat gaacacgagg cttcgatttt attccctgag cttaccattt ccgaagctct 3396301 ggcgctttat ccggcaaagc tctttattac ggaaggaaaa caaggcgtcc gctattcggc 3396361 tggcagcaaa gaggtgctca tcccgtcctt ccctgtagaa cccgttgata caaccggagc 3396421 cggtgatacg tttaacgcag catttgccgt ggccctggct gagggaaaag acattgaagc 3396481 cgcattgcgg tttgccaatc gtgccgcttc cctttctgtc tgctccttcg gtgcccaagg 3396541 cggaatgccg acaagaaatg aagtagagga gctgctgtca tgaaaaaaca cggtatactg 3396601 aacagccatc ttgccaagat tttagccgac cttggccaca ctgataaaat tgtcatcgcg 3396661 gatgccggac tgccggttcc tgacggcgtt ttgaaaattg atctttcact gaagccgggc 3396721 cttccggctt tccaagatac agcggcagta ctggctgagg aaatggcggt cgaaaaagtc 3396781 attgctgcag ctgaaataaa agcatccaat caggagaatg cgaaatttct agaaaatctt 3396841 ttctctgaac aagagattga atacctttct cacgaggagt ttaagctgct gacaaaagat 3396901 gcaaaggcag tcataagaac aggagaattc acaccatatg ccaactgcat cctgcaggca 3396961 ggtgtacttt tctagaaagg aagatgaaac atgcagattg aaatgaaaga cattcataaa 3397021 acattcggaa aaaatcaggt gctgtcaggc gtttcctttc agctcatgcc tggcgaggtt 3397081 cacgcattaa tgggagaaaa cggcgccggc aagtccacgc ttatgaacat tttgacaggc 3397141 ctgcacaaag cagataaagg tcaaatcagc ataaacggaa acgaaacgta tttttccaat 3397201 ccgaaagaag cggaacagca tggaatagcc tttatccatc aggaattgaa tatctggccg 3397261 gaaatgaccg ttcttgagaa tctatttatc ggtaaagaga tatcctccaa gctgggcgtt 3397321 ttacaaacaa gaaaaatgaa agcgctagca aaagagcaat ttgacaaact ttccgtctct 3397381 ctttctcttg atcaagaagc cggcgaatgt tccgtcggac agcagcaaat gatcgaaatt 3397441 gcaaaagcgc ttatgacaaa tgccgaggta atcattatgg atgaaccgac cgcagcgttg 3397501 actgaacgtg aaatcagcaa gctctttgag gtcattacag cgttaaaaaa gaacggcgtc 3397561 tccattgtct atatttcgca tcgcatggaa gaaatttttg cgatttgcga cagaattacc 3397621 atcatgcgtg acggaaaaac ggtagataca acaaacatct cagaaactga ttttgatgaa 3397681 gtcgtcaaaa aaatggtcgg acgggagctg actgaacgat atccaaaacg cactccttct 3397741 ctcggtgaca aagtattcga ggtgaaaaat gcttccgtaa aagggagttt tgaggacgtc 3397801 agcttttatg tgcgttccgg tgagatcgtc ggtgtttcag gattaatggg agccggccgg 3397861 acagaaatga tgagagcgct gttcggcgtt gacaggctgg acacgggtga gatatggatc 3397921 gctgggaaaa aaacggctat taagaacccg caggaagccg tgaaaaaagg tctcggcttt 3397981 attacagaga atcgcaagga tgaagggctc ctgctcgaca cctcgatccg cgaaaatatt 3398041 gccctgccca atctgtccag cttctcacca aagggtctca ttgatcataa gcgggaggct 3398101 gaatttgtcg atctgttaat caagcgcctc actatcaaaa cagcatcacc ggaaacgcac 3398161 gcacgccatt tatcaggagg aaaccagcaa aaagtggtga tagccaagtg gatcggcatc 3398221 ggaccgaaag tgcttatctt ggatgagcca accagaggtg tggatgttgg cgccaaacga 3398281 gagatttata cgctgatgaa tgagctgacc gaacgcggtg tcgctatcat catggtgtca 3398341 tcagagcttc ctgaaattct gggaatgagc gatcggatta tcgttgtcca tgaaggcaga 3398401 atcagcggcg aaatccatgc gcgagaagca acacaagaac gaattatgac acttgccacg 3398461 ggagggcggt aatatgaaaa cggaacaact gcaaacagaa caaaaacgga ttcacttcga 3398521 cggagtcatg caaaaactcg gcccgtttct tggtttattt attctcgtta tcattgtatc 3398581 tattttaaat cccagctttc ttgaaccgct gaatatttta aacctgcttc gccaggtcgc 3398641 cattaacgga ttaatcgcgt tcgggatgac ctttgttatt ttgacaggcg gcattgatct 3398701 ttctgttggc gctattcttg ccctgtccag tgctttagtt gcggggatga ttgtgtccgg 3398761 tgtcgatccg gttctcgcga tcatccttgg ctgtatcatt ggtgccgtac taggcatgat 3398821 caacggatta ttgattacta aaggaaaaat ggcgcccttt atcgccacgc ttgcgaccat 3398881 gactgtgttt cgcggactga cgctagtgta tacagatgga aatccgatta ccggacttgg 3398941 cacaaactac ggttttcaga tgttcggacg cggttacttt ttaggcattc ctgtaccggc 3399001 aattacgatg gttcttgcct ttgtcatcct ttgggtgctt cttcataaaa caccattcgg 3399061 acgccgaacg tacgctatcg gcggcaacga aaaagccgcg ctcatttcag gcatcaaagt 3399121 gacgcgcgtg aaagtgatga tctattcttt agccgggctt ttatccgctc ttgcaggtgc 3399181 catattgact tcccgcctgc attcggccca gccgactgcg ggagaatcgt acgaacttga 3399241 tgctatcgcg gcagtcgtct taggagggac aagtctttcc ggcggccgag gacgcattgt 3399301 cggcacgtta atcggggtgc tgatcatcgg cacacttaat aacggactta atctgcttgg 3399361 cgtctcatca ttttatcagc tggttgtcaa agggattgtt atcttaattg cggtattgtt 3399421 agaccgcaag aagtcagctt aggagggttt tacatgaaaa aggctgtatc cgtcatttta 3399481 acgttatcat tatttttgtt aaccgcctgt tcgcttgagc ctccccaatg ggcaaagcca 3399541 tcaaactcgg ggaacaaaaa ggaattcacc attggcttgt ccgtctcaac gcttaataat 3399601 cctttttttg tctcattaaa aaagggtatc gaaaaagaag ctaaaaaacg gggaatgaaa 3399661 gtcatcattg ttgatgcaca aaatgattca tcgaaacaga cgagtgacgt ggaagattta 3399721 attcagcaag gtgttgatgc attattaatc aacccgactg attcttcggc gatctcaacg 3399781 gcagtagaat ctgcaaacgc agtcggtgtg cccgtcgtaa caatcgatcg atctgcggaa 3399841 caaggaaaag ttgaaaccct cgttgcttcc gataatgtaa aaggcggtga aatggccgcg 3399901 gcgtttattg ccgacaaact tggaaaagga gcaaaggtgg cagagcttga aggcgtcccc 3399961 ggcgcatctg ccacacggga acgcggctca ggattccata acatcgcaga ccaaaagctc 3400021 caagttgtca caaaacaatc agctgacttt gaccgcacga aaggcctgac tgtcatggaa 3400081 aacctgctgc agggacatcc tgatatccaa gctgtttttg ctcacaacga tgaaatggcg 3400141 ctcggtgctc tcgaggcaat taacagctcg gggaaagaca tattggtgat cggttttgac 3400201 ggcaataaag atgcgctcgc ttccattaaa gacagaaagc tgtcagccac cgtcgctcag 3400261 cagcctgaat taatcggtaa attggctaca gaagcagcag atgatatttt gcacgggaaa 3400321 aaagtgcaaa aaacaatatc cgcgcctctc aaactagaaa cacaaaaata attgtctgat 3400381 gtttaggaac ctgcgataac gtgaatagag atatagaatg aattatttct cttacgtgag 3400441 gagaggaacg gcatgaacaa accaacaaaa ctattttcaa cattagcact tgcggctgga 3400501 atgactgcgg cggctgctgg cggcgctggc acgatccatg ctcaacagcc agaaacaacg 3400561 gtaagcattg atgatttata cagttatccg attgattctt atttggtatc agcagaggct 3400621 ctaaatgtca gaacgaagcc ttccgcatca agccagaaag ccgatacgct gcacttagga 3400681 gatagcctaa agctgatttc cttctcaaat gctgactggg caaaggttaa gtataaaaat 3400741 ggaaaaacag gatttgtatc cactcattac attgttaaag cagcgacaac ggtaaaaacc 3400801 aaaacaaaaa caaaagtgta tacatccgct gacggaaaga gcattaagac tcttccagca 3400861 gacacaagcg tttctttttt aggctggagt aaaacgaata aaggcggttt tgattttgat 3400921 tgggtattcg ttgattacgg cggtacgaca ggttatatga aaacaaagga tttacacatg 3400981 acaaaataac tgagagggat tccgcataaa tgcggaatcc cttttattat gaattgattt 3401041 gtcacattcc caagatattt ctcaggaaat attgtcgtat gctgtgtcga aaccttacat 3401101 gatcatcgac atttttgttc acgctaaaaa gcggaggtgt aaatatggat caatttgaag 3401161 cagcatatga atcgtataaa gcccggcaaa caactgccga tcaagaaaat gttccatctg 3401221 gaaaagaaga aattattgcg gttagaagaa atgaggaaga caatattatc gcagtgaaaa 3401281 ccaatacagg aagagagctc gactacccta ctgcgctgtc agaagcaaaa tcaggaaaac 3401341 tcgctcatgt tgatgtcttc cataaatacg ggcgtgacat tttgcgaagt gaaccggacg 3401401 gcatcaagga aaataacctg tctgagctgc cggattttta aacaaataca gccctgccgt 3401461 atgttggaca gggctgtatt ttaaacaaaa ggctgctgga tgtattcggc taaccgtttt 3401521 gcactgtgag aaatatcctc tgcagctgca taattcacgc catagaacac atatggaggc 3401581 agatacttca tgccgatcag attactcgtg gcctgaaatg gtttcaatag ctcactgatc 3401641 gagtaatgat ttgctccgcc cgcttgatat ttttccgctt cgctccctgt tgatacagcc 3401701 agcatcagct ccttgccatg caaggcattt ccttctgaac caaaagccca gccataagtc 3401761 agcacaagat cctgccattt tttcaagagc ggcggagagc tgtaccaata tagcgggaat 3401821 tgaaagacaa tccgatcgta ttcctcgcac agctgctgtt ccttcgcaac atctatcgct 3401881 tcatccgggt attccttata aagatcccgt actgtgatat tgtcatgttt actcaattcc 3401941 tcagcccacg ccttattaac aactgaggtc tccatatgag gatgcactgc caaaaccaat 3402001 attttcatca gaccacacct ttactgtttt gatgttattt tatctaaaat caggaaaaga 3402061 gccaaataaa aagaaagccc tgctaaaagg ggctttcttt ttttctttta ttcagggctt 3402121 ccttcagttg tttcgatatc tttcgcaaaa tcagggttat ccagattcgc attaaagaaa 3402181 tccgctgtgt tcggaagtct gagattcatg ttcatttttt gagaaatcgt aaccgtgcaa 3402241 tcctcaagca catagtcaaa aacgtgtccg cctgaattgc gtccttcgtc aatgaagtgc 3402301 aggtgatagc cagaaacggc gattccgttt gcataagctg gtgtcaagaa acctacaatc 3402361 gttcctctca cgttgtcgaa gttgaaaatc ggctgtgttt tgaccgcttc aaccattggc 3402421 acgtaaggtt tttcttgaag ttctactgtt cttgtctgca cctttttaaa caatccgtca 3402481 atgcgaattg cataaaataa gtttctgctt ggcagcatgc tgttgatctc tttttcaaag 3402541 tcttcgcgtg tcattttcgc atcaattttg tgcgtcatgt ccggtgtaaa gaacgtaaat 3402601 gaacagaacg gtgaacggtc tccattttgg accggtgtcg cggttccgtc tgagcgaaga 3402661 cggtaaaatt cgccgtcaaa cccaatcagc tctccgtcaa gcttgttaaa ggttccgata 3402721 ccgaagtctc catatttcgg aatctctgac agttcaaaat ctccgtcata tactccgtct 3402781 aatagagaag tcattgttga tacttgataa atctggctca caggctgatc tttttgacca 3402841 cggctgagca cttgaatgtt gctttctcgt ttcatatttc ccttcactcc ttttatttag 3402901 tgctgttcat aaaacagtgt cgtgatgcgc agagtgctag agagctttcg ttttcatgag 3402961 ttccccgaat tctttcggaa gcttgtcact tgctaaatta atgttatcac tgtagtcaac 3403021 cgggacatcg atgatgacag gaccttcagc gttcatgcct tgacgcagaa catctgccag 3403081 ctggtctggt gattctacgc gcaagccagt tgctccgaag ctttccgcat atttcacgat 3403141 atcgatattt ccgaaatcga ccgcagatgt acggttatat tttttcaatt gctggaatgc 3403201 aaccatgtca tatgtgctgt cgttccatac aatgtgtaca attggtgctt ttagtcgaac 3403261 tgctgtctct aattccattg ctgagaataa gaaaccgccg tcaccagaga cagaaaccac 3403321 tttttctccc ggtttcacca atgaagcgcc gattgcccaa ggaagcgcaa cgccgagtgt 3403381 ttgcataccg ttactgatca ttaatgttaa cggctcgtag ctgcggaaat aacgtgacat 3403441 ccaaatggcg tgcgaaccga tatcgcaagt tactgtaaca tgatcatcga ctgcattacg 3403501 caactcttta acgatttcaa gagggtgcgc tctgtctgat ttccaatctg caggcacctg 3403561 ctcaccttca tgcatatatt gttttaaatc agaaaggatt ttctgctcac gctctgcaaa 3403621 ttccactttc acagcatcgt gttcgatatg attgatcgtg gacggaatgt caccgatcaa 3403681 ttcaagatca ggctggtaag catgatcaat gtcagcgata atctcgtcta aatggataat 3403741 tgtccggtct ccattgatat tccagaattt cggatcatat tcaatcgggt catagccgat 3403801 cgtcagaaca acatctgcct gctctagcag taaatcgcca ggctggttgc ggaacaaacc 3403861 gatacggcca aaatattgat cctctaaatc tctagaaagg gtaccggcag cttgatatgt 3403921 ttcaacaaat ggaagctgaa cctttttcaa aagcttgcga accgctttaa ttgcttccgg 3403981 tcttccgcct ttcatgccga ccaaaacgac aggaagtttt gctgtttgga tttttgctat 3404041 ggccgcactg attgcatcat ctgctgcagg accgagtttt ggcgctgcaa cagcacgcac 3404101 gtttttcgta tttgtgactt cattcacaac atcttgcgga aagctcacaa aagcggcccc 3404161 agcctgccct gctgacgcta tcctaaatgc atttgtaaca gcttccggta tattttttac 3404221 atcttgaact tctacactgt attttgtaat cggctggaat agcgccgcat tatccaaaga 3404281 ttgatgtgtc cgttttaaac gatctgcacg gatcacgttt ccagcaagcg caacgacagg 3404341 gtctccttca gtgttcgctg tcagcaggcc tgttgccaag ttagaggcac ccggtcctga 3404401 tgtgactaac acgactcccg gttttccagt taaacggccg actgcttggg ccatgaatgc 3404461 tgcgttttgt tcgtgccggg caacgataat ttcaggtcct ttatcttgta aagcgtcaaa 3404521 taccgcatca atttttgcac ctggaatgcc aaatacatgt gtgacacctt gctccactaa 3404581 gcaatcaaca acaagctccg cccctctgtt tttcacaagg gatttttgtt cttttgttgc 3404641 ttttgtcaac accctcactc cttattatgc attttaaacg taaaatttta aatatcttgt 3404701 gataagtttc actatacact ctttggaaat tgacctccaa tatcgattcg ccttatgatt 3404761 aatatgtaat acgaattatt aacctatgga aaggaatgca tattgaatgg agcttcgcca 3404821 tcttcaatac tttatcgcag tagccgaaga gcttcatttc ggaaaggctg cccggcggct 3404881 gaacatgacg cagcctcctc tcagccagca gatcaaacag ctggaggaag aagtcggagt 3404941 tacgcttctg aaaaggacaa aacgatttgt cgagcttacc gcagcaggag aaatcttttt 3405001 aaatcattgc cgcatggcat tgatgcaaat cggacaagga attgaactgg cacagcggac 3405061 ggcccgcggc gagcaaggcc ttctcgtaat cggttttgtc ggatcagcta catatgaatt 3405121 tctgccgccg attgtccggg aatatcgtaa aaaattccca tctgtgaaaa tagaactgcg 3405181 tgaaatatcc tcgtctaggc agcaggagga gctactaaag ggcaacattg atattggtat 3405241 acttcatcct cccttacagc atacagcttt acatatcgaa accgcccaaa gcagcccttg 3405301 tgttttagct ttgcctaagc aacacccatt gacttctaag gaatcaatta cgattgagga 3405361 tttaagagat gaaccaatta ttactgttgc taaagaagca tggcctactc tatacatgga 3405421 ttttattcag ttctgtgaac aagcgggctt cagacccaac attgtccagg aagccacaga 3405481 atatcaaatg gtgattggtt tagtcagtgc cggaattggt atgacatttg ttccttcctc 3405541 ggccaaaaaa ttatttaatt tggatgttac ttatcgaaaa atggaccaaa tacagcttaa 3405601 tgcagaatgg gttatcgctt accgcaaaga caatcataat ccgcttataa agcattttat 3405661 tcatatttca aattgtcagc agacaagaac taaagagagt gatgcaggta catgaacaat 3405721 acttgcaatc tcttttttct tttgggattc ttatggaatt tttattaatt taatataatc 3405781 gcttagtaca actttatatc agtatacgta tacatacagt acaaatagtt ggcaaggaca 3405841 tcagtaagcg caggacatta gtttgatttt aaaaatgaaa gatagagagg tgaagtaaat 3405901 tattgagttc accggcatat tcacattgct cgcttttttc gtaacaatga tttttatttt 3405961 ctggagacca aaaggactaa atgaagctat ccccgccaca tttggcgctt taatggtttt 3406021 attgtgcgga agtgtgtcat tggcagactt aggggaaatc ggaacaaaag tcacgggtgc 3406081 atcggttaca atccttgcca ctatgattat ggccattgca ctagaaagct ttggtttctt 3406141 ttattgggtg gctgcaaaac tgctccaaca atccaagggt tcaggcatca agcttttttg 3406201 gctaaccaat ttgctctgct ttctcatgac cattttcctt aataatgatg ggagcatttt 3406261 gatcacaact ccaatccttt tgcttgtact aaaatattta ggtttaaaaa aacatcaaaa 3406321 agccccatat ttattaagcg gtgttttaat agccacagcc tctagcgcac cgattggcgt 3406381 aagtaatatt gttaatttaa tttctctcaa aatcattgga atggatctat atcttcacac 3406441 cgccatgatg tttgtcccta gtatgatggg actcattttt atgacttgtc tactgtttat 3406501 gttcttttat aaacgtcttc ccaaaagcct gccagatata ccgggccatt ttcagtctct 3406561 gcggcataga aggtaccatc ctcttcattc gccatcagct cctttaccag aacgaaatca 3406621 aacaaaaatc atgttgtttg tgcttgcatt tgtttttctc gtcagaatga gtctatttgc 3406681 agcatcatat accggtattt ctgttcctct agtcgctgtc atcggatctt ttatcctgtt 3406741 gagctggaga tggatttatt tcaaaacctc cccaagagac ttgttatata aatcgccttg 3406801 gcacattttt atattcgctt ttactatgta tgtcttaatt tatggtctgc ataatattgg 3406861 attcacagag ttacttgtga gttattttga acctgtggtt tctggaagcc tcgcccatgc 3406921 aactttcgca tcaggtatct ctacttcagt tttttctaat ctctttaaca accatccagc 3406981 gttaatgatc agtactttta ccttaactga aatgaccctg aatccttcaa caacaaaaat 3407041 catctacttg gcaaatatta tcggcagtga tatcggttca ttattattac ctatgggaac 3407101 cttagcaacg cttatttgga tgcatatatt aaaacagcat gatgaaagta tttcatgggg 3407161 cgaatatata aaaacgacca ttatcatcat tccgctgact gttcttttta cgttaacatg 3407221 tttatatttt tggatcagtt ggttatttct ttagcacagt atgaaacgaa aaactgcctt 3407281 ctgcttttca agagggcagt tttgtataca ctagggaaga tgcattgtct ttagatgatt 3407341 taacttccaa atgactggct ctccacttgc gttaataagc tcaatgatat tattagagac 3407401 accctttaat agtccgactt tttctggcac ctctcccata tcaaatatga ccaattcacc 3407461 aatatttttt ttgatctgct cctcaaaatt acgcacaaga ggaactttgg aaggcacgac 3407521 cggcaattgt gagttgtcaa gagtatacgg tgtttgttca gttgaataag gggtaaacca 3407581 ttttaaatga tgcatagata taaaaagtat tttaaatacg ggtgagaaaa atacaatata 3407641 atcgtttaaa acatttgtaa catatccatg gatcgatcga cccccagtta cataaacttc 3407701 aataaactgg cctttgacct tgtttaatgt atttctatat gaaaaagctt gagtttctgc 3407761 ctctatcatt ggatcttccg gattgatcaa aaatggcttc tcagtactgg tcactatttt 3407821 cgccttgttt atttgatgaa gatgcaacaa gggaatataa agataattgc agccatcaaa 3407881 aataacaaaa atatcctgtc cgatatctat gagggtgccg acaaaccttg tatctcctga 3407941 aatgacaacc tcaacatctg tgttaaggaa ttgattcaaa cctttcacga ttctcctcct 3408001 ttaactgaaa aagggcatca ctttatctga tgctcctcca ttatctatta aaatttacgt 3408061 ttccagtgat agtctatcgt tctgacaatc gtttcatagc tataatcttc cttttgtttt 3408121 cctgaacttt ttattgaact tgaatagcct ggtgatcttg atgattgata atctgaagat 3408181 cttggtgatc gtttagatga ttttgatgat tgataatctg aagattttaa tgatcgttta 3408241 gatgattttg aagaactttt tgaacgtgac gaacggccag atttggatga ttgataatcc 3408301 gaagatttta gtgatcgttt agatgatttt gaagaacttt ttgaacgtga cgaacgacca 3408361 gatttggatg attgatcatc tgaagatttt agtgatcgtt tagatgattt tgatgagcta 3408421 tatgattttg aagaaatgaa cgaattgctg tccttatcat tattgtcttc ctggttttgt 3408481 tcattttttt gatcctcttt tttgtacgac ccttttggac ctaagctgat gctttttatg 3408541 tgaaaaggat agatgcgaag cacctcttga tttttcacta tagtataatg gccgtcggca 3408601 ttatctacaa ggataccctc aatggcttcc ggacctccac gattaattga aacccattta 3408661 tgagtcagac tcttaaaaac ctcgcttaaa tcatcagctt ccaaaactcc aactggcgtc 3408721 tgctcttcta ttttcaaatc aggctcgtgt ttacttatac ttttgatgtg atggatatta 3408781 aaatacacta ccccatcctc atttgtgttt aacgcagcgt aatcatctcc cagccagacc 3408841 aatcttcctt ttttagattc cggaccccct tggttaaatt gaactgattg gtttattaaa 3408901 tgtccgatta agctatgaaa atcatcagca tcgagcattt cctcagtctc aattgttgtg 3408961 gtgctattat tggtatcctc agtaatactt ttcacatgct ccaactgata ataaattatt 3409021 tttttttcag cttgtaaagc tatataatct gattttacag ctgttaattt tcctttttta 3409081 gattccggac ctccacgata tacagtaaca attttatctt tcattgagtg caaaaagtta 3409141 taatacgata tttcattatt tgaatgatat ttcattctcc tcttgctcat tcaaattcct 3409201 cctagtcact tatacataga tgataaacat actgcatata tacgtgtcac atttatttgt 3409261 tgaactaatt caatagccta attgtcgctt tttccgcgaa tacccatttt cacgcattca 3409321 taaaatactt aaatgatctt tgaggtattg tgaacggttt ttaatatact cgcagatcac 3409381 atccggctca cggtcaaaac gctcaatatc attcttttta tacgggtcca tgaggacaaa 3409441 cggcctaatc cgttcataca tcgccatgat tttcggttcc atatattcta ttgtaaaaag 3409501 agattggagc gttttttcta acaggcgctt gtaggacttg cgaaactcgg attcatccaa 3409561 tatccgggcg gttagtgtat taaatccttg aattcttaca taatcggcag ccatccgctc 3409621 tccatggata tccctgcccc aagtcgcatc ataatcccaa ggaatcacct caaataatcc 3409681 ggtttccccg cttctgtata atgcgtagtt gtggacaaac ccgtcatagt tcgaggtgaa 3409741 tacaatacca gcaagccagc gcaaatactt atcgacatcc acgtgttttg tcacttctga 3409801 cttaaactga gctttaggga ccgtattaat tttaaaaatc atatcttgta aataaaaatc 3409861 atcttcctca gtccctgttt tcttttcata tccaagctcc agcgatgttt tcgtttccct 3409921 ttctaaatcg ctcatcagag aaaagttggc atcatcatcc accgcataaa aaatcgcgcc 3409981 atcagccagc ttccttttcg ccaaataata ttcatctacg gattcaagtt caagataaac 3410041 cccttcattc ttcccattca tctttacaaa cgcaaactct gcctttggag acagtgtccc 3410101 tagctccgag aaaaaatcca gagacaattt gtttctcatc aaggaagggt ctttatactc 3410161 cgcatttaag tgaatctctc gcgcgccgcg gaatgttttc ggctgataaa aggaaatatg 3410221 gtatgacttc tttttgaagt ctctgatatg tgatccccga taagcgatat caatatccag 3410281 ccttttttga tttaccttca tcacagctgg caccggatca tcgtcccata tatccttttt 3410341 taattcacgc aagtcttttg gatgaacaaa cagctgataa agcggtaaat tggattgatt 3410401 cttcatccat aatcctcctt acaaatttta ggcttttatt tttataagat ctcagcggaa 3410461 cacttataca ctttttaaaa ccgcgcgtac tatgagggta gtaaggatct tcatccttaa 3410521 catattttta aaaggaggat ttcaaattgg gccactattc ccattctgac atcgaagaag 3410581 cggtgaaatc cgcaaaaaaa gaaggtttaa aggattattt ataccaagag cctcatggaa 3410641 aaaaacgcag tcataaaaag tcgcaccgca ctcacaaaaa atctcgcagc cataaaaaat 3410701 catactgctc tcacaaaaaa tctcgcagtc acaaaaaatc attctgttct cacaaaaaat 3410761 ctcgcagcca caaaaaatca tactgctctc acaagaaatc tcgcagccac aaaaaatcgt 3410821 accgttctca caaaaaatct cgcagctata aaaaatctta ccgttcttac aaaaaatctc 3410881 gtagctataa aaaatcttgc cgttcttaca aaaaatctcg cagctacaaa aagtcttact 3410941 gttctcacaa gaaaaaatct cgcagctata agaagtcatg ccgcacacac aaaaaatctt 3411001 atcgttccca taagaaatac tacaaaaaac cgcaccacca ctgcgacgac tacaaaagac 3411061 acgatgatta tgacagcaaa aaagaatact ggaaagacgg caattgctgg gtagtcaaaa 3411121 agaaatacaa ataatctaag ttttcattgt ttcaataggc tgccggcgga ggtacggaag 3411181 cctatttttt tatttgccct gtattagata tatgtcatga cataacatat gcaacccgca 3411241 tcatttggtt tcctttaaac catttcgtta taatcaaggt atcctaacga taaaggcggt 3411301 tgttgctatg tacatatttc aagctgatca gcttagtgcc aaagacacat acaagctatt 3411361 gtcaggtacc gttattcccc gccccattgc atttgtgaca acactttctt caggaggagc 3411421 ggtaaatgcc gcgcctttca gtttttataa cgtcgtcagc tcagatcctc cgcttctcag 3411481 tatttctgtt aacaggacgg aaggacgcca aaaagataca gcacgaaacg cagtggagaa 3411541 cggagaattt gtcgttcatg tcagtgatga agccatcatt gaagatatca atgaaacagc 3411601 tgcaagctta aggccggatg aaagcgagct tacacgcacc tcgcttcatc ctgttgaaag 3411661 caaagctgtt tcagttcccg gcattaagga agcccgcgtt cgctttgagt gcaaattaga 3411721 gcggcatatt acctttgaca atgatcaagg catcactaca gcagatctgc tcatcggaag 3411781 agttgtctgc ttccacctag atgaaaaggt gtatgatgca gaaaagggat atattttaac 3411841 ggatgaatta aagcctgcct cacgattggc gggaaatcac tatgccaagc tgggggaaga 3411901 attcacactg attcgtccca gctgaagaga aggactattt aaatagaaga aactagtcaa 3411961 aaagacctta tgattacaaa atatcgcctg taaataactg aaaaaatatc aaaaaaaaga 3412021 acacccagag caagctcggg gtgttctttt atgaaacgtt tttccttttt cttcgtataa 3412081 aggtagatta ggaggaattg gaatgacaaa cttttggatt ttaatgctga tcgctattac 3412141 catcagtctc gcctctcaat tttttataaa gaaaaaatac ggtattgata aatccggctg 3412201 gcgatataag catgtcagca atacacacaa atggatcgaa atcactttac ttattttgtt 3412261 tgtgttttca ctctcctttt ttccagttga atatttgctt cttttatttt ttattgtgat 3412321 tgactcaata cgtattttta tggagtggca ttatagacct gaagataaac agtatatgta 3412381 ccacattgta gaggtctccc ttatgtttat gcttttgatt tatgtttgta ccctatagtt 3412441 atttaaatcc ccacagccgc tccgtctccc cgaggatcgg ctccgccttg gagaaagcct 3412501 tcttcatcaa ctttgattgc agccgcttgt cccatcagcg gatcatagtc accgacaacc 3412561 tccacgagat gcccgctgtc tttcagtttt tggattgttt tgtctgtgaa tctgccctcg 3412621 actctgagac cttcgtattc ctctccccac gttctgcccc atacccagcg cggttcgctg 3412681 attgcctgct gtggatgcat tccgtagtcc agcattcggg taatgatggc cgtctgggtc 3412741 tgcggctggc cttcgccgcc ttgtgtgccg tacagaattt ttggctttcc gcctttacag 3412801 accatagccg gcatcaacgt atggaaggtg cgctttctcg gttcaagcgt gttgacatga 3412861 ttttcatcca gtgagaaaaa cgatccgcgg ttttgcagta atatgcctgt atcaccggca 3412921 gtgactgccg agccaaattc aaagtacagg ctttgaatga atgacactgc gttgccatcc 3412981 gcatcgatta cggccgcata tgccgtatca cttcccaccg gcctgctttc tgccggtatt 3413041 gcgagatagc cgatttcttc tgccaattgt tttgcataac gtttgtccaa aagcctttca 3413101 agcggaatgt ctgcaaacgc cggatcagtc aggacggcat cccgatctag aaaactcttt 3413161 ttcaatgcct ccacaagcac gtgataatac tcaaatgaac cgtgttcgat ttgggtgaaa 3413221 tcatagtttt ccaaaatgtt cagtgttaat aaaccggtaa atccctgaga attcggcggc 3413281 gcctgataca cactgtatcc tcgataatca cttgatacag gcgctgccca ctcaccccga 3413341 tgcgctttaa aatcatcgat tgtcatgtaa ctgccgttat tctgtaaatg tgagacaatc 3413401 cgctgagcga gatctccttc ataaaatgcg cttcttcctt tttcagcaat caagttcaga 3413461 ctgtctgcaa gctctttttg cacaaaccgc tctcccggga caggtgcttt gccccttctc 3413521 gtgaagatgt cagccgtgta aggcgtggaa gccagcagtt caatattctt ttctgtgtga 3413581 cgacactgat cagctgatac aggaaaccca ttttgggcat aatcgcgtgc gggctccaat 3413641 acatctgcaa gagacagacg cccgtactcc ttcaggaccg catcccagct atcaaccatt 3413701 cccggcacgg taatagcact gtcaattccc cgcagcggaa tcgcgctttt tcccttatat 3413761 acatctctcg ttacgttttt tcctgaacgg ccgctgccat tgtagacttt tactgccttt 3413821 gtttcctggt gaaaggtcag ccaaaaggaa tccccgccaa gtccggtcat atgcgggtac 3413881 acaaccgcaa gacaagcact caccgcaaca gcggcgtcaa acgcgttgcc tcccttatcc 3413941 agtatgcggt ttccggcttg agaagcgaga taatgcggac tgacgaccat ttgctttgta 3414001 ccgatgacag atttgttcat cacaagtccc cttttttaag aaattttctt cagtataggg 3414061 agcctgattt ttcacatcta ctgatccggc agaaaaactg acgaactttc ttcttttcgc 3414121 aaataataag atattttcgc attcatttcg aaaacaaatg aaaaattatt atttctatac 3414181 gtaactttta tgataaaatg attgctaaaa ggctacgaaa gcaggtggag caattgagtc 3414241 atgaatatca aatccccaac cttgtacttg atgagactga taaacaaatt ctcacgattt 3414301 tgcatgaaga aggcagaatt tcttatacgg atcttggcaa aagagtcgat ttgtcacggg 3414361 tcgccgttca ggcccgtatc aaccaattaa ttgaagccgg tgttattgaa aaattcaccg 3414421 ctgtcatcaa tcccgctaaa atcggcatcc atgtttccgt gtttttcaat gtcgaggtag 3414481 aaccgcaatt tttagaagag gtcgctctta agcttgagga agagcctgcg gtcaccagcc 3414541 tttatcacat gacaggcccg agcaagctgc atatgcatgg gatctttacc aacgatcaag 3414601 aaatggaaga attcttaaca aaacggctgt atccattgcg aggcgtcgtc agtgttgatt 3414661 gccagatgct gatcaaacga tacaaaagcc gtatgggaat gaagctgtaa aggagagaaa 3414721 caaatgaaaa accatcctta tcgggatatg acggccgcaa tggttcgcac cggcatatta 3414781 gggttcggcg gcggaccttc cgtgattccg ctgatccgcc atgaagcggt caataaatat 3414841 aaatggattg acgatgatga attcggagaa atattagcaa tcgctaatgc gcttcccgga 3414901 ccgattgcca ccaaaatggc tgcttatctg ggctttaagc taaaaggcac attaggtgca 3414961 attgtggcga tcctcgccca cattctgcct acatgtcttg cgatggtggg cttgtttgcg 3415021 gctgtaaatg tgttaagcca ttcagcaatt gttgcaggta tgattggtgc cgtcacgccg 3415081 gtaattgcgg tcatgctcgg aatcatggcg tacgagtttg gccaaaaagc gcttaaaggt 3415141 ttcggctggg ttaccggcat cctgtttttt atcatcgctt ttatcggcct gcaaacttta 3415201 cagattaatc ccggcctggt cattatcatt ttcttagctt acggggcgtt tcattttaaa 3415261 ctgaaagaca aaatcacaaa taaacattca aaagataaag gaatgtcagc ctcatgatat 3415321 cgatctattt atttatggcg ttttttatcg caaacctact gggatatggc ggcggacctg 3415381 cgtctatccc gctaatgttt gaagaagtcg taaacagata cagctggctc tcaaacgatc 3415441 aattctcaaa tatgctcgca cttgcgaacg cattgccggg cccgatcgcc acgaaaatcg 3415501 ctgcgtatgt cggctacagc gcaggcgggt ggcccggctt cctaattgcc ctgatcgcaa 3415561 ccgtcgtacc gtcggcgctc gcattgatcg tcctgctgcg catcatccag cgcttccgcc 3415621 aatcacctgt catcaaaggc atgacgctgt ccgtccagcc tgtcatcgcg gtcatgatgc 3415681 tcattcttac ctggcaaatc ggcgcagacg gcatcaaagc gatcggctgg gtccaatcga 3415741 tcgtgattac gggaatttcg ctccttgcca tgacaaaatt caaaatgcat ccggcatttt 3415801 tgattattgc ggcgttttta tatgggggcc ttgtgatccc ttatttatag aaaaaagcac 3415861 ctggacaggt gcttttttat tttagcccag aaatgccgtt tgatatgaca gctgtttctt 3415921 ctcctgcgtc actcttgatc atgtgcttga cttgcagcgt ggttcctgcc attctcacag 3415981 attgcttcaa ctgggacgaa ttggtttcaa cttgtatcca aacaggaggc tggaccttcc 3416041 aaaataaata gagtgcaaga atcagcaagc cagcaatgac cgacagcaaa aacttcatat 3416101 cgcatcgctt cttttcagta agcggctcgc agcggacagc gcctgatgat cacgaagaat 3416161 atcgcctgga cgattgcctt ctcccagcac atagccttta aaggacattc ccataaaatg 3416221 aaaaatatgt tcgaattgct gaatcagcgg cagccctttt atttttggat tgtctccgcc 3416281 cactgctatt acatatgcct gtttcactga catttgctgt ttaaaatcag gaaatctcgg 3416341 atctctcaac gtctgtgacc agcgatcaat aaacagcttt aatgtccctg acatgccaaa 3416401 ccaataaatt ggggtggcga atataagaat atggcactgc aatatccgtt caatgataga 3416461 atcgtagtca tcttgaacag gacgaaagcc gccttgggcg tgacgcagat cttcaattgg 3416521 ttgaattgga tatttctgca aataaatgtg ctccgcatcg aatccttgaa cagccttctc 3416581 cgcaagaaca tccgtatttc cgccagaccg agttccgccg ttaataaccg caattttcat 3416641 gatgcatctg ctcctttgtt tacgaatgat tttcttcatc atataatgga ttcatcaatc 3416701 aatacagatg attatttcga ttaatccaat cgctaaaacc gatttagaaa ggaagagaac 3416761 aagtggaatt gaagcagctg atcaccttta ttacggcggc tgaacatgta aacttcaccc 3416821 taaccgccaa aatgcttaat tatgcacaat caagcgttac ctctcagatc aaatcacttg 3416881 aagaagaaat cggaacgcct ttatttgaac ggctcggcaa gcggcttatc ttgacagaag 3416941 caggaaaaac gttcaaatct tatgcacaga agatcattgc gttaacagaa gaagcgaaaa 3417001 tggccacaaa tcaagtaaga gaaacaaccg gaaccttaaa aatcggggcg acggaaagcc 3417061 agtgcacata ccgcctgccc cctatcataa aagaatttaa acaggctttt ccccaagtaa 3417121 agctcatatt caaaccatat atctccaatg aacaagcgaa agaacagctc ttacagggcc 3417181 agcttgatat caccttcatc ttggatgtaa accggatgga agacgcactg cacgttgaat 3417241 ctttgattca ggatgagatc aaaatggtgg ctgctaatga ccatcctttt cctgcggatt 3417301 taccagtaac attgaaggat cttcaaaacg aaactcttct gctgacagag gacggctgct 3417361 cgtaccgcac gctctttgag aacaatttgc atgactccgg tatctatcct aacaaattgg 3417421 aattcgtcag catagaagcc atcaaacaat gcgtgatggc cggacttggg attggaatct 3417481 tgcctgaaat gacagtaaaa gatgatattg cagcaggccg gatgaaagaa ctcaattggc 3417541 agagcgattg ccccgttttc actcaattag catggcataa ggacaagtgg atgtctgcgc 3417601 cattaaaggc ttttatcgat ttgacacgga aaacattcaa ataaaacctc tccacaagga 3417661 cgacaaggtt tttgagacca gggcacacac atacaaaaaa aacacttgat gacttagagc 3417721 cccaagtgtt acacgtgatt tttctgataa aacgttcgca aaacatgcgt ctcaaggtca 3417781 gccaggcgga cagggatcgg cagcctgctt tcttgattga tcaagctcat cgtgatctga 3417841 tagctgctgt ctaaatcaat ataattaccg caagacaaga aaataggctt cacgtcccgc 3417901 cgcgttcgca gcgcccgtcc atatacctcg ccgtcaatga taatatcggt gtatgcgcct 3417961 acttcaattt caggcgtcac gaaatcgcag cctttgattt tgagataggt tttcgctatc 3418021 ccaatcgtcg gcttgcccag aaaaaaagcc gcatgggtgg caacgcccat atgattgtaa 3418081 tgcagatatc cgttgccatc aaacaagaag acatccggct ccgtctccag ctttttcgcc 3418141 gcctcgatga tcaagggcag ctcgcgaaac gcaagaaaac cggaaacata cggcacgctg 3418201 attctcccca tgctgtgcac tttttcaatg acttcttttg tatcagcgtc aattacgata 3418261 atacagcaca ctccgtatgg ttctccatcc tgctcccaat aggccaggtc gacgcctgcg 3418321 caggtgttga tggagtctgg atggatcgtg ggggataggt tgatacgatt tttaaggtta 3418381 aattgcactt gtaaaaagtc ttgttccttt ttcatatcaa atttatgcac atcaaatacc 3418441 ttcataacga ttgctcactc tcgacctaaa ttaatgtgag tctctcttct cgattctagt 3418501 atttcaaaat gaggactatc tgtatctatc tcgtacttat ttaatagatt gccttcttca 3418561 tcccaattct tttcagaaat tagtatggaa tgctcatact gttgctcact ttttttcctg 3418621 ccattttcaa accaaattat gcttataccg tgcaattgcc catatcggta ttctttttca 3418681 ctttttttat tcccgttttc ataaaattca catgttaaac catgggccag accattctta 3418741 tatttagtaa aatagatgat ttgaccattt ggatataatt cgtaagccag ccctgtaaac 3418801 ggctggccat tttcgtcttc aggattatct aaaatctcat cacttaccga agagaaccat 3418861 aaatcctcaa agtccactcc cttttctttt atactcttca tatcatattc attttccata 3418921 ctttaaagcc tccggtatat aatttgtatt ttgagttata tattcacaat gtggacatct 3418981 aggcattggg acaccttctg gcatcttttt atttattttc ctagcactta ctacatatac 3419041 cattaaatct tttaaatccg catcaggtct ttgaagtaac gcttcattta gagcattaac 3419101 ttcggcatga gaacccgccc ctgacgtctt tatataacct tctttaagtt ctgtaggcat 3419161 atttacaatt ctatcatgaa taagtggatg tagtacctta ggtggcttcc catctatatt 3419221 gtttattcca aaataataat tgcctgtttt tttgtccaat acaccagcta ccgcagggcc 3419281 tctttgtttt ttagttagac cagaagattt aattctacta agttcgttta gtacttctgc 3419341 ccttagattt attcgatggt gaagatcttc tttagacaat acaccatgct tatttcttaa 3419401 atattgaagc ctagtttgtt tttcttcagt agtcttagca atattgctaa taaggctttc 3419461 attactcact ttattgacat atggagcatt tttttggtac aaccgatcaa agtagtgtgc 3419521 caatcctgct ccaccaataa tagtaatagc ttccagcgcc ccttgcttcc gcttctcctc 3419581 agacactttg tttccgaaca tatcccggcc tgtgacagct tctgagaatc cgtttgacgc 3419641 aacaaggccg tatgcgccca tttctgtcat tttgagaatg tctaaggatt tgcctgtttt 3419701 gtaggcgtct aatgcgtgtt cagcagcgat agctgctttt ccggttttgt agatggcttt 3419761 tccgcctttg aaggcccggc ctgcccagcc gacgactggt atgaatccgg cagcggccat 3419821 agctcctgct gtcacacgct ccgcggtgga gagtttttct ccggtaaccg gatcaacgcc 3419881 ttcggttgct cttttataat cataatagcc agtgacttct ccagtaaagt tgcaaactcc 3419941 atcccatgtt ttttcgtacc acggtttgtt tgcttcttcc tcggcttttt cctggagccg 3420001 tcttgcttct gcttgctggg tttttgcatc gatataggtt gttccttgat tttctacttc 3420061 aatgacgctt ttgtagactt cattgctgtg gaaggctttt ttgtcatagt acatagggga 3420121 tgcgctcttc ccattgctgg tggcctgcat gagaacagaa tatttggtga gcactgcgtt 3420181 gtccagagat tctaaatttt gatattcagt ggtcagggat tcatcaagct tatcgacagc 3420241 tgtgattgta tcacgtctga ttttttgggc atcgcccatc ttatctgcat agtcgtcaag 3420301 cgtgtacatg tcgagatcaa taatatcgct gatgcctgac aaaatagaat cgatttcttc 3420361 tttatgagcg gagacaatct ctgaggcttt caggtctcca ttgggcagct catgatccaa 3420421 aaaagaagtt tccacatatg aatcattcag ttcttgatct ttaatatctc ctgaaatgcc 3420481 gtttaaaaac gcaatttgag cagagacaag cgtcagccag ctgtctacga tttctgcctg 3420541 tccctgaaaa aaatctttaa tattgtccgc gccatttcct ttaaaattat cgcctaaatc 3420601 ggcaactccc tgaaacgctt ttttcagcgt attcagctgc tcttcaagcg tctcatattg 3420661 cttttttctg ctcttcgctt cttcgattaa agattttgat tcaaatactt tactcatcgc 3420721 actgcccttt ctgttctatt ttaccgctat cgcctcgtcc tgctctttga gtgaatctac 3420781 gttatccttt gtatcctcga tatttttctg taccgctttt ttgtaatctc cgagcatggt 3420841 tttgatgttc tcctcacgct catggtattt tttcgtataa tcgaggctgt tttttccgtt 3420901 ggatcctgcg gcgccgattg atacgtcagc aagcgcatct ttgacagaat ctaatgtttt 3420961 gatgactgtg tcgtacttca gcttaatttc tgacataaaa aaagatcacc accattttag 3421021 tttactaatt gtatttccga cttcttccgc gaactcttct ccctttttaa gaagatctgc 3421081 tgcaccattt gctatgaaca attccgatgc atatttagct ttatcccatt caagatcaaa 3421141 aattttcccg ttaatcgaag ccatatactc gttatattta tcattcacaa tcttagatgc 3421201 ttccgatttc gcctcttctc ttcccttgtc gaaatcatcg gcttttgttc ccgtccaatg 3421261 cttgcccaat tccggtttca caatttcttt gatttcagtg attgcctctt cttgcagtgt 3421321 gtctatgtcc ttttttgctt ttttcagctt ttcgatcttg tcttccacgt ctgaaatttt 3421381 tccgttgagc gaacttttga tatccgctag catactttca taacccatct gaatcacctc 3421441 ttaatactca aaaagtcgta tggaggggct gatgaagata gacttttcca tactttattt 3421501 ccatatatta tattttaaaa tagccagaag gcggcttaaa tagggtaaat ggcttaattt 3421561 aggcatataa cgctcttgaa atgtaggtat ttgatcttgt ttttgttcgt tatacagcta 3421621 ataaaagcgt tttataaaat gaaatcacct aatgtcatag ttataaaggc acttgaaaga 3421681 ggcagatgtt gttgatctgc ctctttcggc gctgagctta ttgttcatgt ttatgttctt 3421741 catctggtcg gccatgtctg attttgtcat ttggcttcta ttattccccc cttctgaccc 3421801 tttggatcaa aagcttgtat tagctgcagt cccagttgta cagaacgttt gaaaagtctt 3421861 ttttccttag atcttcaggt gtgatgaaaa aattggcgat gccgacgtct ccccacattg 3421921 aatcgatatc atcgtctgaa tcaatttgta acagcatgat ggtgtgttct ttatatgcgt 3421981 attcccgggg atcatgctgg gtaaaagaag cgtatccgcc aattttatgg ccaaatccgt 3422041 tttcagccag ttcattataa atgtcttctt catcctcgcc gaactgacca aagaactcca 3422101 ttgtttccat gcccgtatac tgctcaaatt gaaaatctgt aggcagcacc cattccgaag 3422161 atttcacagg ctcgactgcc gcttctgata aaatcggaaa atcacattcg cctgtgccaa 3422221 taaatgaaaa atcagaaaca agctcgtcat cgttttctac gatattttca aaatagatca 3422281 ctctgaaatt cttttgttca catcgatcgt caaaattcaa tccatagacg tcatcatgaa 3422341 cagaaatgta gaactgcagg atacctgaag aagggtagcc gtcaagctgg ggaatgtgcg 3422401 agaaattaat ctgcgccaga agtttcatcg gctgtccatt ttcgtcagtc ggatatgttt 3422461 catgcttggg gaaataggga tcaccggcaa ttttgctgtc atatcgtcct gttttcccct 3422521 ttctcacatt cagtttcacg tattctttcg ctgatttctc cagcaagtcg cggtacggtc 3422581 tcattttttc gggcagatga ttcatcagat tctctccttt tccggcatct ccaaggtttt 3422641 attttctggt tttcttctaa tgtttttcaa acgaatgttt aaagaagccc tacttctgca 3422701 taattttcca aacaatagtt aaatagtagc aaatgtattc agcaccccgc aatagatgaa 3422761 aaaaagactg gtgcgcaacc agcctttctt tttcatctat tgaattgcac ctgacggaac 3422821 aaccgccttc cgtccgacag aataatactc cactcctgca gccaaagcct catccaatgt 3422881 gtagcagttt ctgccgtcaa atatgagcgg cgtttccatc aaatcctgat aagccgctaa 3422941 cgggaattgt ttaatgtcag cccagtcggt taaaatcatg acggcgtcag accctttgac 3423001 agcttcctcg atcgtctctt tatattcaac agcttgcggg agaacatgct ttgcatggct 3423061 aactgcaatg ggatcgtagg ctctgatacg ggcgtcgagc gcagcgagac ggtctgcaat 3423121 aacaattgac ggcgcttctc tcatatcgtc ggtattcggt ttaaatgaca ggcctaaaag 3423181 ggcaatcgtt tttcccgtca ccccaccgag cctgttcagc gctttatcaa ccagcatcgc 3423241 ctgctgattg ttgttgactt tgataacgga tttcagcagt tcaaaatcat gctcgacatt 3423301 gccggcaatt tgcacgaggg cgtttgtgtc ctttggaaaa caagagccgc cgtagcctat 3423361 gcccgctttt aaaaactggc tcccgatccg cttatcctgt cccatcccgt atgcgactgc 3423421 ttcaatatcg gcgccgacct tttcacatat attcgaaatt tcgtttataa aactgatctt 3423481 agtggccaga aaagcatttg aggcatattt gatcatctcg gcgcttctga tatccgtttg 3423541 gtaaatcggg atttgaaacg gacggaagag ctcctccagc gtatttgctg ttttctcatc 3423601 ggccgtcccg atcacgatcc tgtcaccatg aaaggtatca tagatcgccg acccctcacg 3423661 caaaaattcc ggattggatg cgaccgaaat actgacaggc tccgctagat gttcagtaat 3423721 cagtccatta atcaaatcgt ttgtcccaac gggcactgtg cttttcgtta ccacgactgt 3423781 atctcgtttg acatgctttg cgatgcgttt ggccgcatct gtaatttgct ccagattggc 3423841 gtgcccgtcg cttttctgcg gtgtgccgac cgctataaaa atgatgtctg cctgtgccaa 3423901 gcctttctca tagctcgttt caaagttcag ccgtccatca gctgtatttt ttctcatcag 3423961 ctcttcaaga cctggttcaa atatggggga aatgcccttt ctcatttcat caatcttgtg 3424021 agcgtcaata tcaatgcagg ttacatgatg tccaatctca gaaagagaaa cacctgtcac 3424081 aagaccgaca tagcctgttc cgatgactgt tatattcatt gtttccctcc aacagttaaa 3424141 ttgctgcttt gcagcttccg taatatcgta tgagaacatc ctatcatgaa tgcgaatgat 3424201 ctcccgcata gcctgtcggg tacagcctgt acagatttct gaaatgtgat tcaaccatac 3424261 aatacactat tatatcgctc tcaaaaagaa agtggtgaaa tgagaatcgg ctgttaaaaa 3424321 aaaccaaaca attttcttct tttgaccggc tgcggaggct gtctgaagat ggtctgattc 3424381 cgcaggagaa gctctgcatt ttccgtcagc atataaggaa gttccgagcc gaattctttc 3424441 tctagaacat aaagagcctc ttgagtgtga aaatttctcg ttttcacatt atgggcatct 3424501 gaggctacga aatggatcaa attggcttca accagccgga gagaaaatgc tttcagctgc 3424561 ttgccgaaga tccccgcaag acttcctgaa gtaatctgag atgctgctcc tttttccaca 3424621 agatgataca gcaaggacgg gttttcgcga atttccctgt tgcgttcagg atgggcgata 3424681 accggaatat atcctttcag ctgcaaatca taaaaaagct gctccgcata tcggggaacg 3424741 tgatcaaacg gaaactcaat caagatgtat tttgtatcat tcagcgaaag cagctgacgt 3424801 ttggcaaggt cttgttccac ctcgccgtag attctgattt cctgtcccgg aagcacatgt 3424861 aaaggaatgt cttctttgat taaacgtttg tttaactgat ctgctgcttc tctgactgcg 3424921 gctggctcgt ttttatacac accgttgtta tgatgaggtg tcgcaatgat cgtccggatt 3424981 ccctgacgaa cagctgctct tgccatttct atgctgtcgg ccgaatcacc tgccccgtca 3425041 tccattgcgg gaagaatgtg acagtgaata tcgatcatgt cctagccccc ttttttcgca 3425101 aaaataaata acgggcacga tgcacgttat ttatttttgc atgaaattgt ccttggttcc 3425161 gtaatatccg tattcagagt gcttcgaaag ctttttgccg ttcataatcg ccccaaggag 3425221 cttgcttttg cacgttgcaa gcgcctcttt cgcttttgcg gcttgttctt tttctgtttt 3425281 cccgcttgaa ataaccagaa cagaaccgtc tgccacgttg cctaaaatct gtgcatctgc 3425341 tacggcaaga ataggcggcg tatcaaaaat gaccatatca tatgccgcac acgcttcgta 3425401 tgcaagctcc ttcatccact tcgaggagag aagctcggcc gggtttggcg ggatcgggcc 3425461 gctcgtcagc acgtcaagat gtttttcatt cgatgcttgt acagcctgct ccatagagct 3425521 tttctttaat aaaacagatg ttaagccaac cgtattttca agaaaaaaag ccgtatgtac 3425581 tgttggtttt cgcaaatcag catcaatcag gagcactttt tttccctgtt gggcgaatac 3425641 gacagccagg ttggcggccg ttgttgattt tccttccccc ggacaagccg atgtaatcat 3425701 gactgatttc atttgccggt ccactgaagc aaattctata ttcgtgcgaa tcgtccgata 3425761 ttgttcagag ttcaaggatt tcggctctgt cattgcaatg acatttctct gcatccgcga 3425821 gcctctgttt tttctaagcg ccaaaatgtc cactccccgt tttttcagat tggaaaccct 3425881 gtaaggtctt tgctgttttc tgctcattcg caatggtgga aactgtccct aaaacaggta 3425941 tgtccagcaa ggattcgagc tgctcttccg atttgatcgt attatccaaa tgctcaagca 3426001 ggaaggccag tccgatgctt cccgccaatc cggccgcaaa cgcgatggca atgtttagta 3426061 gcggctttgg cgatacaggg gacgggtgtt ctgaaacctc ggcttttgac agaatgctga 3426121 cattgtcaac attcataatg gatgtgattt tgtcttgaaa aacagatgct atagtattgg 3426181 caatatgagc cgctgtttcc gcgttttcat ccctgactga tatgttgacc acttgggagt 3426241 cctgttcgct ggatacggta attttgtcat tcagttcttg ggatgtcatc gacaggccca 3426301 tttctttaat gacttcatct aagatggcag ggctcttaat gatgacattg tacgtattga 3426361 ttaactgaag attggtttgg acatcgttaa attggacttc ttttcgttca tttttcgatt 3426421 ggttgaccag aatctgagtt gaattttcat agatgggtgt aagtgcgaag aaactaatga 3426481 gtccgccggc agcagtggca gccgcggtta caatcataat caaaagtatg cgttttgtta 3426541 acgttgataa tatctctttt aagcttgtag attctcccat gatacctcca aatctcttat 3426601 aacatccttt tccatctacg attatacaac gttgaaaccg catttctcca gcttttcacg 3426661 tgacataatt cgacattttt ttacaatgcg ttatgttagt actttttatg taagcgctat 3426721 atttactgtg ttgacagtgc tgtctcattt tctcttattc gggcagtcac gttctctcgc 3426781 ataaaaaaat cccgctaaag gcgtgcggga tttttatgtt gcatatccat ttttaatatg 3426841 agaaatcaaa ttttcaagca tttccttcgt cgtcatctca gatgactgct caccaatttc 3426901 atgtgcatgc atcaaaattt tcagaaattc ttcttgattc aatttctttt cactcatctt 3426961 ttttttcctt tcagcttcca ttaagttgaa aacacgatta ttatatgatg ctggttatca 3427021 atttgcaatc tctaatacat cattcgacac atcctatttt ttatgtcctt ttttaggaaa 3427081 aactttttaa ggccgatgtg ttgcgatata atagagaaat tggatctttt tattacgtga 3427141 ctcggttagg agcgataatc atgcttcaga atatgatttc caaagacgat gtgctggcat 3427201 ctgctgaaca gttaaaagaa cttcttcctt acaatgagga aaatgttcag ctgatcaaaa 3427261 aagcccttat tttatatcgg caggattcag tctatcgttt acaagcagtg agtccgacgg 3427321 aagttacggc ttacgtgcag gatgttgtgc ctgtgcgggt cacattgaac ttgtttgtca 3427381 tagtcaaaag cggctgttca tgtccgtccg gaagaatctg ccgccatatg ctggctgtgt 3427441 ttttatatgt atatgcaatg ttcgagcgag tgggtacttt tacagagtat tggctggaga 3427501 gggaaaagct tgaggaaagc aaagagctcg tccgccgcca gtttcaggaa aaggtgctgc 3427561 ctaatgaaga atcactttca agctggcttg ctttttttga ttcagagttt tctctctggc 3427621 aggcacgtac gccagaaggc agccaaaaca tgcagggcct ctattacggc tacctgtccg 3427681 cattaaaaaa acatgcgccg aacaagccgg agctgaaaag cctgtatcag attcattccg 3427741 cgattgcggt ttggcttcgc atgttcacat tgattgaagc gggcaagcta aaccccgaac 3427801 aagattttta ttccctcaat ccgtacgttg aacagctgat ggatacaatc tacagctcta 3427861 ttgataaatt aaaaacgtac gcgctgtctt ttgcgcttga tccgtttttg gataaaacac 3427921 cggatgttat ccggcatttg ctgttgaaag aagaaatttt ccaatatgaa cgcatccgcg 3427981 tcttcggtga aatttggagt gcgctgctgt cgcggccaaa atgggtggca cgcgaacagg 3428041 agatattgaa aaaagaagca ggacggcgtt tttctcccga attgcaattc gggcgcctgc 3428101 atttggaatt cctgcaaaaa aatgatgacg ttatttttga ggaagcggat caattcccgc 3428161 cggaagcgct cccttataca ttccaatggc tgagtgaaat gactgccaag aaggactgga 3428221 aacggcttaa aacatggtac cagcaaattg aaccaattgc gatgggttat acgaagctgg 3428281 ataagccgtt taaagagatt cgcgatgtga tcggcgagct gttccttctg ttgaatgcct 3428341 atgtgcagca aaccaatgat caagcgctgt ttgagcgctt tgccgcgggc tgtctgccgt 3428401 atacgttcac agaatacagc catcatttat atgaaaaaaa acgctatgcc gagtggattg 3428461 aaattcatag ccttgtcggc ttttccatca atgaaatgga taaaatgatg ctcaaggaaa 3428521 ttgcagcgag cgaccctgag gcgcttatac cggcttacca tagagaagtg gcttttttca 3428581 ttgatcagaa gaaccgtagc tcgtacaagg aagccgcccg gtatttgaaa aaattgcgca 3428641 ccctgtacaa aaaagcgaaa aagcagaagg tgtgggagcg gtatattcag ctgctgagct 3428701 cgcattacaa gcgcctgcgt gcgcttcaag aagaactgca gaaaggaaag ttgattgatg 3428761 gcgagtctta aagaaattct catccacgtc gaacaaatgg aagatgggtc atttacgctc 3428821 tcagcctttg atgagaatga gcagcctctt ccctacagcc atatgaaaaa gcatttgttc 3428881 caatggcatg aatcctcatt ttacggaacc tttctagagg atgtcagctt catcgggacg 3428941 actgctgtcc ttctatctcc atggatgact gtagagcttc tcggcaaaaa ctcgttcaac 3429001 tcattcagct ccgtgcagct tacagaagaa acggagccgc tgatcgaggc ggcatcgacc 3429061 atctatgaat ttatcgcgga cggcgatttt atgcctgact atgacgcatg gacaaacggt 3429121 gtttttcgct ggaaggaccg cgataatata ctggaaggct ttactgcgga atggttttcc 3429181 gctgccgtac aggattacat ccagtacgac gatgacctgc gggagaaatg ggaacatatc 3429241 aaggaaaaat cgcctgcggt tacgacattc cgtggccatt ttcttgatga agaggatttt 3429301 ctggaaggca ttggctggat tgacgatcaa tctccattta ctgtcggctt gcgcttaaat 3429361 gaaccggact ttgacggaga cgaatggaag atcgagatgt ttttacgcga taaaaagagc 3429421 ggtgctgtag aattctttga cggactgaag agcctcaaaa aatcgtggca ggcgtacagc 3429481 gataaaatcg cgcgtgagca ggaccgcttt cacagaacgg ttccgtggct gtcgtttgat 3429541 tccgggacaa cgctgatctc ggaggaagaa gcctggatct tcctgtcaga agcaagtgag 3429601 acgcttgtcg atatgggggt agaaatcctc ctgccgtcct ggtggcagat tgtcagagac 3429661 agcaacatga tgctgaaagc aaaggtgtct tcctccccgc gcggcgagtc atttgtcggc 3429721 atgaatgcac tgcttgattt caactggcgg tttgcgacaa atggaattga actgactgag 3429781 gctgaattta atgagcttgt cgccagcaac aggcgccttg ttaatatccg cgggcaatgg 3429841 gttaaaatcg atccgcagtt tatcaaacag atgaaacgcc tgatggaaaa agcagaatca 3429901 gagggactcc acatgtctga tattctggcg cgggagctaa tggatcagca ggatggcgga 3429961 cttgaggatt cggacctgat tgatacatct gcttttgccg gcattcagtt tgatctgtct 3430021 aaacagctca ggtcactgat tcgaaagctc actgccgcgg aaaacctgcc ggagcacaaa 3430081 gtcagtcctt ctttcaaagg aacgctccgc ccttatcaga aatacggcat gaactggctg 3430141 ctgtttctgc gggaaagcgg ttttggcgcc tgtctggctg acgatatggg gcttgggaaa 3430201 acgattcaaa tgatcgccta tttccttcac gtgaaggaaa gcggccgaca aaaaacgcct 3430261 catttgatta ttgcgccgac atccgtactt ggcaactggc agcgggagct tcaaaccttt 3430321 gcccctgatc tgtctgtcgc gctccattat gggccgcgcc ggccaaaggg tgatgatttc 3430381 gccgcgcatt atgaaaacgc agacgtggtg ctcacttcat acggtctgtc acatgccgat 3430441 actgaagagc tttcttctgt gacatggaac acgatctgcc ttgatgaagc gcaaaatatt 3430501 aaaaacgcgc atacgaagca atcacgcgca atcaggaagc tgaaggggct tcaccatatc 3430561 gcgctgagcg gcacgccgat ggaaaaccga ctgactgagc tgtggtctat ttttgacttc 3430621 atgaataaag gctacctcgg cagtttgacc ggcttccata aacgctatgt gctgccgatc 3430681 gaaaaagacc gggacgaaaa gagaatcgga cagcttcagc aattaatccg gccattcctt 3430741 ctccgccgga cgaaacggga tgaagaggtc gcgcttaatc ttcctgagaa gctggaagaa 3430801 aaagaattta tccctctgtc agccgagcag gcatcccttt atgagcagct cgtcaaagac 3430861 acttttgacc atatgacatc cctgaccggc atgcagcgaa aagcgctgat cctcagcatg 3430921 cttggacggc tcaagcaaat atgcgatcat cccgcgcttt atttaaagga agagcaaacc 3430981 gagctgctgg ccggcagatc agtcaagctc gaaaaattgc tggaactgat gacagcgatc 3431041 cgcgcccaaa acgaaagctg cctgattttc acgcaataca ttcagatggg gaacatgatg 3431101 aagcggctgc ttgaaaaaac gttcggggaa cctgtgcaat ttttaaatgg gagtctctcc 3431161 aagcaagagc gggatacact cgttgagaaa tttcaaagga aagaatatcc gacactgatt 3431221 ctttcactca aagctggagg caccggactt aatttgaccg ccgccaatca cgtcatccat 3431281 tatgacagat ggtggaaccc ggcggttgaa aatcaagcga ctgaccgtgc ataccgcata 3431341 ggccaggagc gctttgtcca cgttcataaa atgattacga caggaacaat cgaagaaaaa 3431401 attgatgtca tgcttgaatc caagcaaacc ctgaacgatc aaattatcca aagtgaaaac 3431461 tggattaccg agctttccac acaggagctc gaagaattgt ttacattaag cgctacagcg 3431521 caataatcat gactaaaaaa gctggctcta aaagagccag cttttttccg ttcatagccg 3431581 tcacgccgaa tttccaaaaa atccgttacg ccggttatca acagggtgcg cttttgtggc 3431641 agcacatata cttacaacaa atgtttcatc atatgtgcga caccgtgttc gtcattggtt 3431701 aaggtgacag catcggctat cgatttgatg tcttcccggg cattgcccat cgctacacct 3431761 tttcccgcag cctccagcat cgatttgtca tttaaactgt cacctacagc agcagtttcc 3431821 tcgagcggaa tattcagctg ttttgcaagc ctcttcagcg cctgcccctt ggaagctttg 3431881 cgggaagaaa gctcaaagtt gtgctcagcc gaactgacaa gcgtcaaatc ttcggcatgc 3431941 tcatatcttt tccagcctgc ctcaagcttt tctttgaaga aagaaaagcc gagaatattg 3432001 taaaaatcga ttggctcatc ggcttcaaac agctcttgaa aggagttaat gtaagcaaag 3432061 cccgattggc tgtattgcac ctcggccgcc tgcttaagga cagaaagatc cgcttccgga 3432121 tttgcgcttc tgaatctgtc gagctcaaca tcaagaagtt ctctgccgtt ttgcggcgta 3432181 taaatcgctg aacctgtgaa tacctcataa taatagtttt ccgactcaag ccatgagaga 3432241 atgtcatacg cccgtttctt atcaatcgtt tcgtgatgat aaagcctgcc ctcgggatcg 3432301 tgaatgacgg cgccgtttgc actgatgacc catgttttga tccccagcgg ttcaaagatt 3432361 gacatgacgt caaaatgagc gcgcccagtt gacaccacca cttcaatgcc gtcccgctgc 3432421 gcctgccgca gtgcgttttc attttccaag cttacctgat gcttgctgtt gagtaaggtt 3432481 ccatctaagt caatcgcaat taatttcacg tttgtcagtc ctttccttca tcctgctctg 3432541 tcacgagaag ctcaacgccg tttcggtcaa gcaagtcaca aaatgcctga ttcggcagcc 3432601 tgtctgtaat caagaggtcg atttcattca gctccgcata ctgataaaaa ctggtgctgc 3432661 ccagcttaga atggtctgca agcgcaatta cctgctttgc ctgctgtatc attttccgct 3432721 tcaccatgcc atcctcttca tgcgcaattg taatgccatg ttcggaaatg ccgaccacac 3432781 caatcagcgc tttatcaaca tggtagcttg agagcttttc aatcacagag gacccgtaca 3432841 gaaagcggtg ctccttttcc agcttgcctc ccagcagata aatttcaatt ccctctttat 3432901 cggacagcac atccgcaaga ttaatcgaat tggtgattac ggtacaatca accgcattca 3432961 aatgctttgc acatgcctga acagttgtag aggcgtctaa aatcacccgg tctccatcat 3433021 gaataagcga tgctgcaagc ctgccgatct tatttttttc ctcagacact gttttcaggc 3433081 ggccggaata gctttgaatt ttctgatgca cagtcggtaa aatggcgccg cctcttgtgc 3433141 ggatgatggc attctgttcc tcaagtttca caagatctcg tcgcgctgta tcccttgaca 3433201 cttgcaggag cgtacagatc tgctccgttg taattcggtt atgctgtttt aaaaaatcca 3433261 aaatcgctac taatctttct tcttggtaca cgccctcatt ccttttctca gcaatcattt 3433321 ataagtaatt ataagttttt atttgatttt attcaacatt aataagtgat tttaagtaaa 3433381 aatgcgtcga gagaaccaat ttttcctaag taggcaaaaa gaaagaacca gtctggtcga 3433441 ctggtcaatt ttgaggggat gatgcgaaga tccggataat agtgaatgga tagataacgg 3433501 gaggagcagg ggtgtcaatc agcagctttt tcccggggtt tagggtccat aaaacgaaca 3433561 gtgtcagcca acacttctgt tacatacacg ttaacgcctt cctcgttttc atagcttctt 3433621 gtctgaatcc gtccgcttac gccgacgaga gaaccttttt ggcaatacaa cgccgtgttt 3433681 tcagctgttt ttctccaaag tgtgcaattg acgtaatcag cttcgatttc acctgaagca 3433741 ttcttgaagc tgcggttcac cgcgagcgta acatgtgcaa ctgccgcacc ggcggaagtg 3433801 tagcgaagat caggatcttt tgtaagacgt ccgacaagca tgacctgatt gaacatgcga 3433861 ttcctcctct ccttgcggtt gtatgtattg taaatgatgc aacaagaaaa gaaaaacgct 3433921 taaaaatggc tttcagcctc tgtttttatc tttcgttttc atttttcctt cagctaaaaa 3433981 catcttttgc ttttttcctt tgaagaaata tgtacttttt aaaaaacgga aaaagatttg 3434041 ctttgtcagc cagttttgcg tattcatgcg cacataggaa gagccatccc acgcaaacca 3434101 ctgaaagctc aatttttttt ccggcattga cagcttgatt ttatactgct ccatgccatc 3434161 ttgtgtttcg tataaaaaac ttattcttcc ttttttgttc agatgaacct caaacacttc 3434221 tttacggctt aacatatatg ttacttcctt ttgaatcaaa tgactttcag aaggaacgcc 3434281 gtcaatataa atttctttta aacgaaattg attcatacca catctctccg taatccatag 3434341 tcagttacag tataatgaaa aaatagaaat tattaaatgt ttcgctcata caaaattctt 3434401 tagccccaac attgcaggat tttttcctcg aaaacgttta tgttataatg gaaggcaaga 3434461 aaactttgga agtaatcggg gtgagaagaa atgaaaacct ttaaactggt tgacctgaat 3434521 gtggaacgag tggacaagga agaacaatca attgaacagt ttccccttat tgacggactg 3434581 attataaata aagaagacgg tgaaaatcac tggctgattg aggcgcttgt acagaaagaa 3434641 catctgtctt tttttgaaca gcttcaaaac agccaatctg aagccaaagt atttgtaacg 3434701 atcacgaaaa aaagcaatcg ccccgcccag ctgacagcag cagtgaaaaa tatcgtcaag 3434761 ctggaagaaa gcattcaggt tttactctac ggacaaatgg tcacaagaaa acagcagggc 3434821 actgaaacca ttctcgagtc ccttgtaaaa gagggctata caggaacaaa actcattgag 3434881 gcatttaagc aaaaattata aatatgaggg ggcatgttcc ccaaaacaga ctcagaaccg 3434941 aagagcatca caatagacat ttagaataga tatgttctgc atgaaaaaag ctgccgtttt 3435001 gaacggcagc ttttctcttc gtgctttcac tcttgcatat ttaatttgta tggccaaaag 3435061 aatcaaccaa ttcccctttc acaacgaggc gcccttcggt tttgaccgcc ttgtcacatg 3435121 tgattaacgt aatctccttt ttgtttgtct cctcaactac atctgcatcc atttccgata 3435181 tgatgtcttt cgatgttaca gaatagatat aatccttttt aaaatccgtg atgacaattt 3435241 gggcacctgt ttttatgttt tccagaggtc cgaacagaag attcttttgc ttcaaatgat 3435301 ggcccgccaa cggataattt ccctcaccca ttttttgatc ccggcgcatt gttgccgccc 3435361 ctatcaaaag attttcattg gttgtgcctt ttacgatcgg aagctccaga tcgacacttt 3435421 taattgttat ccgccgcctt gattgtgaag taaaaataag tatatttcac gtgctttcga 3435481 cgttctccac ttgactggaa tgctttaatg gcgatcccgg catctgtagc ttcaggcttt 3435541 ccttcagagg aatcagaaat ctcaaactct attttctcag tgttcagcac ataaccggct 3435601 ggcgctttcg tttcaacaaa agcgtattgt cccggtgcaa ggcctgaagc tgtgacttga 3435661 tgatgccgga tatgactggt ttcgaagtct gtatgaaaat tcgcgaacga ttcagcatgg 3435721 ttgatcttcc ggttctgatc attacagctg ccattatcgg ccatgacaaa tacaaggctt 3435781 ttcatgccgg agcgaatgac attttgcaaa aaccctatca ttactctgaa tttatggcgc 3435841 gtattcaaaa cctgataatg atgaaacata cagcaaatca agccacaaga atggaaatgg 3435901 cgtttctcca gtcgcaaatc aagcctcatt ttctttataa tgtattaaac acgattattt 3435961 ctctcactca tttggatatt gaaaaggccc gggaggtaac agaggaattt accaactatt 3436021 taagaatgag ttttgacttt caaaatacat cagccatcag ttccttcaga catgagcttt 3436081 cgattatcaa ttcctatctt tctatagaaa agacgcgatt cagtaatcgg cttgaggttc 3436141 ttttcgatat agatgaagac attgacttta tccttccgcc tttaatgatt cagcccttgg 3436201 tggaaaatgc cgttcttcac ggtgtcagca agaaaagagg cggaggatgg atcaaactga 3436261 cagctaaaaa acaaagcaaa aatgagtatc acatcaaagt agaggataac ggtcccggga 3436321 taactccgga aaaacaaata gatctcttat caacggattt tgatcgcagc gtcggattga 3436381 aaaatatcaa tcagcggctg aaacattttt gcggaagcga gttgatgatc agcagcactc 3436441 cggatgcagg cacctctgtc tcaatgctca ttcatctcgc tgaaacaaca ggaagcccta 3436501 aagaactgaa ggacacagaa cgaacctaaa cgaaaattga gataaaaaaa gacgccgttt 3436561 ctaacggcat cttttttatt ccggcgactt tgcttgctgc ttcagcaggt ctctgatttc 3436621 tttcagcagc tcctcctgcg catccaccgc ttcctccgca gcctcttctt ctgcttcttt 3436681 tttgcgcctt aacccattca aagtccgaat gacgataaaa atggagaacg atataattaa 3436741 gaagttcaca atcgtctgta taaagctgcc atatttcact acagcatcgc caaacgtaaa 3436801 cgacaggcct gaaaagtcaa gccctcccag cagcaaaccg accaaaggca taatgatatc 3436861 atttactaga gatgtgacga tctttccgaa agcgccgcct atcacaacac caatcgcaag 3436921 gtctacgata ttcccccgca tggcaaaggc tttaaattca ttccacatac aatcacctgc 3436981 ttttctatat ttgtaaagaa aaaaagacaa atgtgccgct ggccatctgc cttttttcaa 3437041 ttattctccg agggcaaaag tcagttctac ttcgcaaacg acttcgccat caactgtggc 3437101 aacgcctttt ccgcgcccga ttgtgccgcg ggcacgaatg atttcaacct caaggtgaag 3437161 ctggtcacca ggcttgactt gttttttaaa gcggcagtta tcaatgcctg caaaaaaagc 3437221 cagtctgccg cggttttctt ctttaatcaa catcgcaaca gctccgactt gagcgagtgc 3437281 ttctacgatt aatacgccgg gcataaccgg gtactgagga aaatgtccgt taaagaactc 3437341 ttcattagcg gttacatttt tatagccttt tgcccgtttg ccctcttcaa cttccgtaat 3437401 ccgatccaca agcaaaaacg gataacggtg aggaataatt tctttaattt gctgagtatc 3437461 aagcattgtc ttgacatctc cttcatctgc attagtatgt atagcaatca tcaaagatcc 3437521 aatctgtaca tttgaaaagt atattatgaa ttaatctctt tttcaaccgc gctaaaatgt 3437581 aaccaactgt caatgagagc cgtcaaaagt tatgatatga taattataga ttttaccaat 3437641 agcaaagagg taggaaaatg atttcgaagt ttattgaaaa aagaatgcta aacatgttag 3437701 acgagtggta ttccgcaatg agcaaacgca aaatgaatca cgtttgcaca ctgaaagaga 3437761 aaattgatca gcaccttcca aagatcaaaa agaacacaaa actttggatg cgttatcaat 3437821 tgtttcaggc ccgccatcag ctgctttttg aaaaccagaa cggactcgat tcattgttcg 3437881 atggcctata tggcctggaa gacaaaatgg atgatgaatt gaaatattat ctgtattttt 3437941 tctctgggtt atatgagatg gtaaaaacag ctccgaaaca tgcagtacat cattttaaaa 3438001 aagctgaaca gtacctggcc gccattcaca atacgtttga agccgctgat ttatattatc 3438061 aaaccgccgg cgcctattac ttgatgaaat caccgccgct ttccgtccaa tacgtcaaaa 3438121 aagcattaca catctatttg caccaattcg gctatatcaa aaaggtaatc acctgtaaac 3438181 ttttgctcgc cgtgaattat attgatcaag aacgctatga aaaagctgaa cagcttttca 3438241 aagaaatcat taagaaaacc cagcaactac atgacgaaaa cctgctatgc cacgcttatt 3438301 ataaccttgg ctttttaaaa gcgaccgaga aaaaagacca ggaagcgctt ctttacttta 3438361 gaaaagtatt aaagaatcaa gaatttgaaa tgaattcacc agtctcatat cttcattgtg 3438421 tgtacgagtc tgtcagagcg ctttttaaaa cagggaacat cacagaagct aaagccgtcc 3438481 ttcaaaaagg aaaagaatta tctgaaaagg tagacattca aaccatttat ttaaaattaa 3438541 aaacgcttga agccctctac acatcagccg aagaccctta tgagcagctg ctcgaatatg 3438601 tgcttgaatt agaaaaaatc gaggcgtggg tggatttaga agtgctgtta gaagatatta 3438661 cggaatacta caaaaaaaag gacgatttcg aaaaagccgc tttttttatc atgcgcggct 3438721 gattgaaaaa cgcccatttt cttattatct gactgaattg attaaaccga gcatttgatc 3438781 tcccattgtg atcgttctgc tgttcagctg atatgaacgc tgggacgtga tcaaatctgt 3438841 catttgttct gaaatatcga cattggacat ctcaagtgag ccctgctgca tgccgatgtt 3438901 ttgtctatta gcgccgttca gctcttcaaa agctgccgca ttatcaatag agaaaaggtt 3438961 attcccttcg gatttcagct cttgagggtt attcacttgg acaacgccaa gattaaaccg 3439021 ctgaaccgcg tttccgtcag atgcggttaa ggtgccgttc ttattaatgg tgatattctt 3439081 cattgagctg tcgatgttca ctgtattgcc gttctcatca agtacgggat acccatttcc 3439141 agtgacgagc tgcagctggt tggcattcgc agcggacggc gttacataca gcgccccgtc 3439201 cctcgtatac tggcggtttc catttacatt tacctgaaga tactggtatg gagacgtaaa 3439261 tgcgatatcc agatcgcgat cggtcttctg aatgcttcct tgatcagaga ctaggcgtga 3439321 actcatcatc gctccgacgc caaggcgcaa gccgggcggc gtttttcggg cttttgccac 3439381 ttcctcgttt ttttcatcaa cctgatcgaa ttgctgtctg acaagctcag aaaaattcgt 3439441 atcttttgcc ttatagccgg ttgtgttgct gtttgaaagg ttgctgctga ttgtgtcaat 3439501 ctgctgctgc agctggttta aggttgttga tgccgttagc attgacctga gcatagttga 3439561 tgtcccccgt ttttttcttc cgttttctta aatttttcca atttcatttg ctgctttatc 3439621 catactttta tcgtaagcct gaataacctt ctgattcgcc tcaaacgatc tgtacgcttc 3439681 agtcatttct gtataggcgc ttgtcacatc cacgtttgaa agctctgaga cgccttgttt 3439741 taatgaatag gctacctgat tatttccggc tgcgcttggc agatcattac cgtccgccgt 3439801 gctgtacaaa tcatttccgt cccgtttgag attgcggaca tcttccgcca ttctgacatc 3439861 aatctggccg gctgtgcgtc cgttcgttgt cacagtaccg ttttcagaca cagtgaaatt 3439921 ctcattatca acagtgattg gctggcgatc cgtcgataaa atagggcgtc cgttgatcgt 3439981 cagctgattg ttctcattta gtgaaaatgt gctgcttttt gaataacgga ttccatccgc 3440041 tgtttgaacc ggataaaaaa gagcagcttt ttcattggtt tccgcactca tcggaacttg 3440101 attttcgatc aatgcaatgt ctgtaggctg gtctgtggac ttcaggcttc cctgtgtaaa 3440161 gagaggcttg agctcctgca tatatactcc ggtattcacg gaaccgattt ccgtccttga 3440221 tgtcccggcc ggagattttg attctattct gctgagcagc atctcaggga acgcgcgcat 3440281 agagccttga tcagctttat atcctgatgt atttgcgtta gcaatattat ttgaaagcat 3440341 ttccgttctt cgctgctggg caatcattgc ggatgttgct gtatataatc cttttaacaa 3440401 atttcccacc tctaaaaatg gcattttttc cagttgtcat ataggaacgt tcgttctata 3440461 ataaaaactc agtattttat cctattatcg tcatttaaca tcttttcgtg aaggcttttt 3440521 cataaaaaaa cctcattctt tttcagaatg aggtttgtga aatcagctta gtttgcgttt 3440581 aggaagcttg tccatattat caagcatgac acctgtgccg atggctacgc aatccatagg 3440641 attttcagca acgaggaccg gtaccttcag ctcttcagca agcagctggt caaggccgtt 3440701 taagagcgcg cctccgccgg taataataac gccgcggtca ataatatcag cagaaagttc 3440761 aggcggtgtt ctttcgagca cttgttttgc agcctgaaca ataacagcga cagattcacg 3440821 aagggcttct tcaacttctt tactgtttac tgtaattgtt cttggaagac cggaaaccat 3440881 gtcccgtccg cgaatggaaa tttcctcgtg acgtgcgtct gggaaaacag ttgcgacttt 3440941 aatcttaata tcctccgcag tacgttcgcc gatcagcagc ttgtactcgc gtttgatata 3441001 atttaagatt tccatgtcaa acttgtcccc agccatttta atagaagagg aggtgacaat 3441061 atcgcccatt gaaataaccg cgatatccgt cgtcccgcct ccgatgtcta caaccatgtt 3441121 accgcttggc tggaatattt ccatacccgc gccgatagcg gcaactttag gttcttcttc 3441181 aaggtacaca tgtttcccgc cgcttttttc tgcagcttct ttaattgctt tttgctcaac 3441241 ggatgtaata ttcgtcgggc agcaaatgag catgcgcggc tttgagaaca ggccttttac 3441301 attcagcttg ttaataaaat gtttcagcat tgcttctgtt acttcaaagt cagcaataac 3441361 tccgtctttc agcgggcgaa tcgcaacaat attcccaggt gtacgtccaa ccattcgtct 3441421 tgcctcttcg ccaaccgcca gcactttgcc gctgttttta tcaagtgcaa caacggaagg 3441481 ttcattcaga acaattcctt tacctttaac atggatcagt acatttgcag taccgaggtc 3441541 aataccaata tcccttgcaa acatctattt atatcctcct tgaaaatctg tttcacagta 3441601 aatatccaca ttgtgcccta attatatata ttatcataaa atatagaaaa aaagttggaa 3441661 gcacaataag ttctttacaa atttttgcgg atgttttatg aacgatttca agaaggcaat 3441721 gccaggtgat tacgattgct gaacaggctc tccttcgaga atttcatctt ttttatattt 3441781 gagctttgtc gcttctcctc ctcttaaatg cctgatggat ttatgataat cgagtatttc 3441841 tttcacttcg tttgccaagt cggggttaat ttcaggcaga cgctctgtta aatccttgtg 3441901 tactgtactt ttggaaacac caaattcctt cgcaatgaca cgaacggttt tctttgtctc 3441961 cacgatgtac ttccctatct tgattgttcg ctctttgatg taatcgtgca caccactcga 3442021 cctccctaaa atggatgtga gaagtgtgaa atgagatccg tattctgtaa agagtcgttc 3442081 attatgccgc ttcttcgttg tatggtttta aaagtaagtt tgtgaaatat gcccacgatc 3442141 cctcacctca aacactctct ttgttaggtt tgtaacagtg tattagcatt cttttgggaa 3442201 tatgctaaaa actcaataag gacaaggggt gaaacgaact ttttcagatt cagcaaacta 3442261 tttcgcgtca ctaaattttc atctttacaa ctattgatcg ctcctgtaaa atgaaataag 3442321 caattagtta cttaggtaag ttttttagaa ggagaccgac atgtcctacg tcaacagaca 3442381 cctcattcat caaatcaacc aaagcgcccg cctgattgcc aagaaagcca atgaacagct 3442441 agagccattc ggcctttatt catctcaatg gtcagtttta tattgtttgc gtacgatcgg 3442501 accaatgact caaaaagaga tttggtccta tttaaatgtg gaagcgccga ctgtgactcg 3442561 gacgatcaaa cgcctggagg agaacggctg ggttcagaga cggcaaggtg aagacaaacg 3442621 ggaaaaactt gttgtcctca caaaagaagc cgagaaaaaa tacgaagaaa tcaatgtgaa 3442681 aatgttgaaa ttcgaggaag agctgcttgc agatttccgg gatgaagata aagaagcttt 3442741 ttctcattta ttccgcatgt ttttacaaca atgaaaataa ggaagtgaca tacatttgaa 3442801 aaaagcggat gcgatatgga ccaaggattt tattatggtc ctgcttgtca atttatttgt 3442861 gtttgtgttc ttttatacat ttttaactgt attgccgatc tatacactgc aagagcttgg 3442921 cggcacagaa tcacaaggcg ggcttttaat cagcctgttc cttctgtctg cgatcattac 3442981 acggcctttc tccggagcca tcgttgagcg tttcgggaag aaaagaatgg cgattgtatc 3443041 aatggcgctc ttcgccctat catcttttct gtatatgccg attcataact tttccctgct 3443101 gctcggattg cggttcttcc aagggatttg gttcagcatt ttaacgactg ttacaggtgc 3443161 aattgccgct gatattattc cagccaaacg gcgcggtgaa gggcttggat actttgccat 3443221 gtctatgaac ctcgctatgg cgatcgggcc tttccttggc ctgaatttga tgagagtggt 3443281 aagctttcct gtattcttta cagcctttgc gctgtttatg gttgcgggct tacttgtttc 3443341 gttcttgata aaagtgccgc aaagtaagga cagcggcacg actgtattcc gttttgcgtt 3443401 ctcggatatg tttgaaaagg gcgcactcaa aattgcgacg gtcggtttgt ttatttcttt 3443461 ctgttattca acagtcacat catatctgtc tgtattcgcc aaatcagttg acctttcgga 3443521 tatcagcgga tatttctttg tttgttttgc ggtgacaatg atgattgcac gcccgttcac 3443581 agggaaattg ttcgacaaag tcggaccggg cattgtcatt tatccatcaa tcctgatttt 3443641 ctctgtcgga ctctgcatgc tgtccttcac acatagcggc ttaatgcttc tgctttcagg 3443701 ggcggttatc ggtcttggct acggatcaat cgttccttgc atgcaaacat tggcgattca 3443761 gaaatctccg gctcaccgct ccggttttgc gacggcaacg ttctttacct tctttgacag 3443821 cggaattgct gtaggatcgt atgtattcgg attgtttgta gcatctgccg gcttctctgc 3443881 catttattta acagcggggc tgttcgtttt aattgctctg cttctctaca cgtggagcca 3443941 gaaaaaacct gcagaggctg aaggaaaagt gtctattgca gaataacttg tcagactgcc 3444001 gggaaatccc ggcagtcttt tttccattaa aacacggcgc cctctcggtt gaacgagaga 3444061 acgccgctta tagcaattat tcaatgacag gccgcgcagg tgaatcagga tctaacgaaa 3444121 aatcatagga cgcttcatca cgaaacatcg gatcggcata tatggattgt tgatcgtttt 3444181 ttgttgcttt tcgatacgaa gaaaatgaat catattcttt ctttttccac atccatatgc 3444241 cgtcttgatc cgcttccttg tggtacacgt tatgattgac cgtattacct tcgttttctg 3444301 taaagtcgtt tccgataaat aatctggaat caccggccgt caatatattc ttttcaattg 3444361 tgttgttttt cgtatcgtac tgcagcagca gctgtccgcc gtacagtccc tttgtgtcat 3444421 tccggtacat aatattgcgg gcaatcagag aattgctggt gccgccccgc tttttgtcat 3444481 atcctccgat tgaaataccg gtgtacgcat tgttgtacac tttgttgtct gtgatctgaa 3444541 tggcatttgc atactttcct ttgtgttcag acgttgcttc aatcccaata tcgttatcgt 3444601 aaactgtgtt gttcttaatt tcgatatcgt gtcctccatc gacataaatc ccgcccgctg 3444661 agtattcatc tccataagca ggattgccgt aagtcgagtt ttgataaact gtattgtttt 3444721 ctacgactcc gtttcgcacg taatcgtttt tatccgcggt tccctcataa ccaattagat 3444781 caatcccgat gttattattg ttgcggacca cattgcctgc aactgtgaag ccgtcgatat 3444841 taccgttcag cacaactgct tcactcgctc caagcgtcag tttctcaact gtattgtcct 3444901 cgattcggat gtctttcatg ctgccagtcc cataaactgc gattccgtga gcatttcctt 3444961 catccgctgt tgtcttaatc ccccggatgt gattatcctt aatggcgata tgactgctgg 3445021 accctgatac ataaatccct atagcagttg cttcctcaga tgaaacagaa agatcttgaa 3445081 ttgttaaacc gctgatggca atgtcatgtt tatcgtgaat acgaataagc ggtgtttcat 3445141 attcagcgtt cgcaacggat tcaccgctaa tcacgacgtt ttcattttca tagtttcgga 3445201 atgtgatagg ctttccgtcc gtaccgctgt gctttacatc aagggtctca tgatacgtgc 3445261 cctcccgaat catgacagtt gtgccggcag cagccttctc agatgcgtgt gccaatgtac 3445321 gaaacggctt ttcttttgtt ccttcatttt gatcactgcc atttggcgaa acatacagat 3445381 aatccccaga tccttcctca ttcgcttttg tcttatcata aacgaaagcg aggatgacag 3445441 acgttaaaac acccgccaaa agaataaaat accattttct cattttcgat tcccatttcg 3445501 ttttagaata gatttctaaa accattataa atgttctatt tatggaaaac catttcaaaa 3445561 atatgaaaat ataccgtcta aatagatctt attcagcctg gcggacctgc gcatgttcaa 3445621 ctgtttcaat tgccaatgat gcaggcgggt gaacacgcat cagaacaatg tagaaaagaa 3445681 aggaaatcag cacacctaca aaccaagaaa tatcgtataa gctcttcaat acaggaacat 3445741 acatgccaat cagcgaaatc agcgctccta acattgtggc tgcaaacgca cggtaattgt 3445801 agcccttcca atacacatac cgtcctgttt cggaatacag gtcatctacc gagagctcac 3445861 gtttgcgaat gataaaatag tcggccatca tcacgcctgc caccggtcca agcatgccgc 3445921 ctattaagcc aagaaacgca tacacgcttg tcgcgctctc catcagcttc cacggaaccg 3445981 taaataaagc gagcaacgct gtgataaagc tgccacgttt gaaattgata tatttcggca 3446041 gggcattcgc tatatcataa gcgggtgata cgatattcgc cgcgacattt acagagatcg 3446101 tggcgatgca gagtgtgatc acggacaaga cgatgacata agggttatca aaccgcgcca 3446161 aaatatcgac aacatcccaa atcggctctc cgaacgcgac ctgcgagccg gaggtcaccg 3446221 taatacttgc gaatgcgaac agcgcaaacg ttcccggcaa accgtaaaat tgtcctttga 3446281 tttgctcttt ttgtgtttca gcaaaccgtg taaaatcagg tatatttaag atcaatgtcg 3446341 cccagatgcc gatgatgcca gtaactccgg cagcaaacgg ccagaatgtt tctgaaaacg 3446401 tatgaaactt tcctggttga gagtatatcg ggcccaatcc tccagcaata tcaacggccc 3446461 accataccat gccgccaaat accagataca ctaaaggccc tgcccacacc tcaaaacgtt 3446521 taatcgactc catgccgtga tgcaatacga gtaaatgaat ggcccaaaag aatacaaagg 3446581 aaagcaaacc ggacaagtga atgccgagaa tgttccactc gccgccaatt tctccccaac 3446641 ctggccacat attcaaaagc aaaatgttca gtgccgtgct acccgcaaag gtctggatgc 3446701 caagccacat gatagctgta aacgccctta gaagcgcggg gatattcgcg ccgtatatcc 3446761 cgtaagaagc ccgaatgatc actggaaacg gcagcccgta ttttgtcccc gcatggccgt 3446821 ttaaggcaag agcgccaaat aggataagtg atgccgtaat aatgatcgcc agcacctgcc 3446881 aaggcgaaag gccgatcgca attaatcctc ccacggtcgc gtaggtcggt atgttatgta 3446941 tacatcccat ccaaatggag gcaaagttca ttgctttcca cgtccgtttt tcctgtccca 3447001 aaggcaccag atcttcattg ctcagcctgt tggattgctg ctgactctct tttaatttca 3447061 tagccggctc ccctttccat attgtctata tgtcgtcaca cgttatgttt tttgacatta 3447121 gatgtcactt aatataactg aagagtcaga caataacact ggctatgata tacaattttc 3447181 ccgtttgtat ttgaacagct taaacaagaa aaagagacag acctcagagc ccgtctcttt 3447241 cttaagatgc agttttcatt aatgcagcaa atctcacagc cattaacagg cttgctccgc 3447301 ccgctataat cataatgatt cccatcatat caaaatgggc tgccgtgatt tctttaccaa 3447361 aaagaatgcc aaggatcacc gaagacaaaa tcgatcctag gtaacggcag gtttgaaaca 3447421 ggcctgaagt cgttcctacc atgttggaag gactcgtttc cagcatcgct gcctgaagcg 3447481 cgacattgcc cagtccgtag cctataccca agagcgacag aatgaggcct ttaccgatgg 3447541 tctggacatt gataaaaaag atggttaaga gcacggctcc agccgtcatc aaaagcgctc 3447601 ccgcaaagat cggcttgacg acaccagatc ggtcgatcca tttgccggtt agaggtgaca 3447661 caacgatgct cattccagac ataaacagca taaacaggcc gctcgtttga acagaaagat 3447721 gcatttcatc ctgaaagtaa cttggcaaac caaaaaataa acaatagaag aaaacattca 3447781 ataaaataaa ctgaacatac acggctgaca ggtttcgctg tgttttaaac agacggacat 3447841 caataaacgg cttatccgtt ttcagctcgc gccagacaaa cgcacagagc agaagcaagc 3447901 caagcacacc ttcaaccgca tgcggcgacg tgctgaacga cagcaaaaag gatagaagga 3447961 aaatgattcc cccggcaaat aaaacaattc caagaatatc gagctgccga ataatggttt 3448021 tgattcctgc cccttttttc tgatctttcg ggaacatata caggcccaat aagaagctga 3448081 ggataataaa cggcaaatta acgataaaga tcgccggcca gcctccccat acaatcaaaa 3448141 acccgccggc tgtcggcccc agcgccgtca tggcggacgc aaaaatagag agtacagcca 3448201 aggctgaagc ttggcgctca tgaatatgat tccgaatcaa gccgacacct gacggataaa 3448261 tcgcactgct ccccaccgat tgaaacagcc gcatgaccaa taatgtcata aacgtcggcg 3448321 caaacggcgc cccgatggca gaaaccgcaa caagaataag cccgaataaa aacaagcgtt 3448381 tccgcccaat caaatcaccg agctttcccg ttacgggctg cgctacggca ctcgccaagt 3448441 aaaacgagga aatcagccag gaaaccgttg taaacgagag gtgaaactca tgctggatgc 3448501 tatggagcgc aagagagatc atagacgagt tcagcggatt cagcattgtt cccgaagcca 3448561 cagctgttaa aaaaacagct cggctttttt tcgataacat catttcactt gttccagaaa 3448621 ctcttccgtt gtccgcgatt taccgattct cgggaaaata aagcgcagtg tggcttcatg 3448681 ctcttcatcg ctaaatgtgg acatggcatc tgtaataaaa atctgctgat agccaagctg 3448741 aaatgcctcc cgtgctgtgc tttccacccc gatattcgtt gcgatgccgc acaatacaat 3448801 cgtatcaatg ccgcgacgtc tcagctgcaa gtctaaatct gtgccaaaaa aagcacccca 3448861 ttgccgtttt gtcacagtat aatcgccatc ctgcacaccg atttccggaa caaattcggc 3448921 ccagtccgcc ggcatttccc ctgaacctcc ctgcgcaggc tcatccgttt gcggcttcag 3448981 ggcgtccgct ccatcatgaa aggctacatt tacaaagctg atgaacccgt tatgtttccg 3449041 aaattcatct acgagctttt tcgcgttcgg gacaacctgg ccgctttgat caatcggcac 3449101 aattcccttt tgtaaatcaa tgataaccaa tgctgttttt tgaaaatcaa tgttgagtgt 3449161 attcatcata cgtctcctcc tgatactgtt agtgtttctc acattgcata ttttactctt 3449221 cacactgcct aagttctttt atgatgcttg tgaaattctc agaaggagcg ttttctcatg 3449281 atttttcttt tatgtagtag taacaggttg tgcatacgaa caaaccggca agcactgtaa 3449341 tcataaaggg cgtcatcgct tcatcacctg cctgctgtct atcggttcct gcctgaaaat 3449401 gcccatgaat ttgcggcggt ccatccaaag caggataaga cacataacca ttaatatcgt 3449461 gctaagatcc tgcacgccaa tatcaaaaca atagttaatc aagacgatgt tcacaataat 3449521 gggcataaaa ataaccgccc ctaatgcagc cgttcgcgga atcagtaata aaacagctgc 3449581 caggatttca ccaaaaccta taaacagttc atagacatga gaataaccga aaaatgtcca 3449641 cgcgatcgta aaccccttcc cggcagccgc ctcgatttca ggcgtcacct cgccaaactg 3449701 gccaattacc actttcgcca gaccgtacac gaaaaaatta aaggctaaaa acaatcggaa 3449761 cgtcgcggga atcgacttgc gtaccgcttt cctcagcctg ccgcctttat tcatcataca 3449821 tccccctcag tgtattattt gatgtagtac acttaataca gtatagagta ttctaattaa 3449881 tgtcaattcc cttttcagct catatgaata gtttctttta tagatacaaa gtcttatatc 3449941 gcaaaaaatg ccattctcct tcctttccat ccctcgataa catttctcaa aaaccatgtc 3450001 aggaaatctt acatgaaaat gttttatcat tcttttttct ctataatgaa gaaatataat 3450061 aattgctttt tattctgaaa gatacggagg aatgagacat gcaaatgggc gatacagttt 3450121 ttatgttctt ttgcgcttta ctcgtgtggc tgatgacccc gggattagcg ttattttatg 3450181 gaggaatggt aaagagcaaa aatgtgctga gcactgccat gcacagtttc tcttccattg 3450241 ccatcgtttc catcgtttgg gtgctgttcg gatatacact tgccttcgca ccaggcaatt 3450301 caatcatcgg cgggctggag tgggcaggcc tcaaaggggt cggatttgat ccgggagatt 3450361 acagcgatac catcccccac tcgttattta tgatgttcca aatgacgttc gccgttctga 3450421 ctacagcgat tatttccggg gctttcgcag agcggatgcg attcggcgct tttcttttat 3450481 tctcggtttt atgggcctct ttggtttaca cacccgtagc gcactgggta tggggcggcg 3450541 gctggatcgg ccagcttgga gcgctcgatt tcgctggcgg caatgttgtt catatttcct 3450601 ccggggtggc aggacttgtt cttgccattg tgctcggcaa acggaaagac ggtacagcgt 3450661 cttctccgca taacctcatt tacaccttct taggaggagc tttgatttgg ttcggctggt 3450721 tcggctttaa cgtcggcagc gcattgacct tagatggtgt ggccatgtac gcgttcatca 3450781 acacaaacac cgcggctgca gccgggatcg ccggctggat cttagtagaa tggatcatta 3450841 acaaaaaacc gacaatgctc ggagcggtat ctggggcaat cgccgggctt gtcgccatta 3450901 cgccggctgc cggatttgtc acaccgttcg cttccattat tatcggcatc atcggcggag 3450961 ctgtttgttt ctggggagta ttctcgctta aaaagaaatt cggatacgac gacgcgcttg 3451021 acgcctttgg cctgcacggg atcggcggca catggggcgg aatcgcaaca ggattattcg 3451081 caacaacctc tgttaactca gcgggcgcag atgggttatt ttacggtgat gcaagcttaa 3451141 tctggaaaca aatcgtcgcc atcgccgcca cttatgtttt tgtatttatt gtcactttcg 3451201 ttattattaa aattgtaagc ctcttccttc cccttcgcgc aactgaagaa gaagagtcac 3451261 ttgggcttga cttaacgatg cacggggaaa aagcatatca agattctatg tgaggagtga 3451321 cgctatgagc ggtcaaatgt tcaaggtaga aattgtaacg cgtccggcaa attttgaaaa 3451381 gctgaagcag gaactcggaa aaatcggagt gacctctctg actttctcca atgtacacgg 3451441 ctgcggcctt caaaaagcac atacggagct ctatcgaggg gtaaaaatag aaagcaatgt 3451501 atacgagcgt ttaaaaatag aaattgtggt cagcaaggtt cctgttgatc aagtgacaga 3451561 gaccgctaaa agggtgctga aaacgggatc accaggtgac ggtaaaatat ttgtctatga 3451621 aatcagcaat acgatcaaca tccgcacagg cgaagaagga cctgaagcac tttaatatcg 3451681 gtacgagatt cggacactcc ggatctcttt ttttgtgcac agaatccccc cagaaaccgc 3451741 gattcctctt cgaattctct tcaagcgccg ttatttcaga caatctctat ttttatttga 3451801 aacttttcat gagtaagatt agtctactaa atataaaaat gtaaaaggtg attatttgaa 3451861 ctacgaaatt tttaaagcaa tccatggact atctcatcac aattcagttc tcgattccat 3451921 tatggtcttc atcacggaat atgccattgt cgcctatgcc cttatcctat tggcaatctg 3451981 gctgtttggg aacacacaaa gcagaaaaca tgtgctatac gcaggcatca caggaattgc 3452041 aggccttgtg atcaactatt tgattacgct tgtttatttc gaaccgcgcc cgttcgttgc 3452101 gcatacagtg catacactga ttccgcatgc tgcggatgct tcatttccaa gtgaccatac 3452161 gacaggtgca ttagcgattt ctattgcgat gcttttcaga aaccgcaaaa tcggctggcc 3452221 gcttgtcatt tttgggcttt tgacaggctt ttcgagaatt tgggtgggac atcactatcc 3452281 ggtagatgta ttgggcagcc tcgttgtcgc catcattatc gggttccttt tctttagatt 3452341 ttcagatctg cttcgcccgt tcgtcgattt ggtcgtgagg atctacgaag ccattatcaa 3452401 taaactgacg aaaaaaccaa ccgatcaaaa tttctaagaa agacaaaagc cggcgtctga 3452461 aatcaagaca gccggcttta atatttctca tacatctctt gttttcttcg cttcgccaac 3452521 acatataaac cataaaacaa cccaattcca acagcatcga tgagcacatc ccggatacaa 3452581 ccattcctgc tgaagaagag ctgaagaact tctgtgaaaa aagcaaacgc aaatgagccg 3452641 gctgcagctg atcttatgct gccccgctgt ttccacagca aatatgtcag cacaaagaag 3452701 gaaaacgcgt gtccgatttt ttgaataaac gcttcaggta cagtaagctc agtaaaatcc 3452761 ataactaaaa attgagacag atcagggtgc ggctgaaaat gaaaagccac cgtttgcgat 3452821 acgaccatgc cgctgaagct ttccgtacag acagaaagca ggataaaaaa gatccagcct 3452881 gcgagcaata ggcggttcat gacataacct cctttataac gtacgtgcct acatgtaact 3452941 acatagacgg taaaacaaag caaaaagtaa cagaaaaaaa cgcccatcac aaggatagac 3453001 gttttcttca ttaagactgt tcagtgtctt ctgttgtgct gctttcttta gaaccagatt 3453061 tgtcagttga atcatccttt ttctcaccgg atttttcttc tgttcctttt tcagttgatc 3453121 cgtccttttt ctcggaagat tgctgaatgg attcttctgt ttcttgggtg gcagcttttt 3453181 caatagaaga aactggtttg tccataaagt ttaacggatt cattgcaacc ccatctttac 3453241 ggatttcaaa gtgcacgtgg tttccgctgt cttcactgta aaggttcttg ccagattttc 3453301 cgatcacttg attttgtttt actttgtcac cttgctctac gcttacttcg gaaagagatt 3453361 gatacacagt cgataaaccg tcggcatgtt ctacttccac aacatatccc agcactggat 3453421 ctttttcagc tttaacaacc gtaccgctca gagaagcaga gacatcgaaa tcttttccgt 3453481 ctttctcagc taagtcaatt cctttgctta ggctgtacgt gttattatag gtaacgagtg 3453541 ctgcttcttt ctcttctttt gcggcatcgg tttcatagaa ctttttcaca acagaaacgt 3453601 tttcagaatc aacaaccggc attgcgacat tttccattga ctttcctact tcaactgcat 3453661 cgtcgttgtt gtcatatgcg gagtttccgc cgttatcagc caactgatcc tttacctcat 3453721 catttgatac tgattgatac caaaggacag ctgttaaaat gacggccgca ctgactaagt 3453781 aaattgcagg gaacacccag cgtttacgaa aaaactgctg aagttttttg acttgagaag 3453841 ttttcttttc ttcctctctc attgtttcat cacctcagca acattctgaa cacttttctg 3453901 aaaatatata caacctatcc aaaaaaactt ttttagatgt agtttgcaca gactgaacga 3453961 aaatatgtat ttttttgaga ggagtgccaa aaacgtatga acatgacatt gcgtcttgct 3454021 gaacatagag acttggaggc tgttgtggcg atttataatt caacgattgc ttctcgaatg 3454081 gtaacagccg ataccgaacc ggtaactcct gaagaccgga tggaatggtt ttcgggacat 3454141 acagagtcac gtccgctcta tgtggccgag gatgaaaacg gaaacgtcgc tgcctggatc 3454201 agctttgaaa cattttatgg aaggccagcc tataataaaa cagcggaagt cagcatatac 3454261 attgacgaag catgccgcgg caaaggtgtt ggatcatatt tgcttcaaga agcgctccgc 3454321 attgccccga atcttggcat ccgctcactt atggccttca ttttcgggca taataaacca 3454381 agcctgaagc tgtttgaaaa gcacgggttt gcagaatggg gactattccc cggcatcgcc 3454441 gaaatggacg ggaaaagata cgatttaaaa attttaggga gagagctttc atgattagtc 3454501 tggataaaga tgaaaacgaa attgaacatc ataatgaaga aaatagcctt gttgaacagg 3454561 agactgcacc tgttggacag gagagccgcc agctgagcgc ctccgctgtc aagtcgctat 3454621 ccgacattgc caagtggggc aaaatttctg gcatcttgtt aatcattatg ggatcgcttg 3454681 tcactctgtc tgttttgatg acagtgattg gcgccatccc gggcgtactg ctcattattt 3454741 caggcgtatt tttgatgcgc tcagcaaaag cagccgcgga agccgaagga aatctaaccg 3454801 gcagcgctgg cgaaagcatg cttgaaaatt acgggacatt tataaaaatg cagctgtttt 3454861 atgcagcatc cagtatcgtt actgtcctga tcgggatcat tgtagccatt ttcgtgctgg 3454921 tggtaatcgg cattgctgct tttgagaaca cgccttcgta tgatgatccg gattcttatt 3454981 attatgagga tgatccggtg tttgaataat gatgagacag gacagggcat gagttccata 3455041 taaacggaac catgcctatt ttatttgact attcaaagca ggccggcgta aacaccaaat 3455101 cctgaagcaa gcatacaata gacatctcta gtagaggaaa tcaacaaagc aacgctgtta 3455161 cccagaaatg aatatcaaaa aaacggatga agtcggaatc aatccgaaac cgcacttttt 3455221 atttcgggtg tctgcatgca aaaaaacaca cccggatcgt ctggaaaatc tcaacaatcc 3455281 gggtgcagat cttctttaat acattttttt gcgtctgtct tcctcagtca aaaattcaac 3455341 aaaactccgc atcgcaaaag gctcttcctt tatttgtcgt gcgtaggagc ttttccgctc 3455401 ttctgaaagg atttcgctct ttttgatcct gttcagcata tagatgtgaa ccgttttttg 3455461 gatttgttta tgctgatagc ctgcctcttt aaaaaatgcg agcccgagcg ccgccaaaag 3455521 ggcgaatatg cctgcgctga tcagggactc cctgtcagct gaagcatgaa atagaaaagc 3455581 agctaaatta aagagagaga atgcagcaag cggaatagca agaaaacggt aaatgacggt 3455641 ttttttcatg aaaggctgta cggccttttg aattttttgc atttctgttt tgatgaaccc 3455701 cggcatttgt tcgactctgt aaaagttcat ataatcctcc ccctttattt gatgtttcaa 3455761 gcttcacgaa cgttatcata tgtgtttatt ttaacgcagg tgcaagctgg ttttaaagaa 3455821 atctgcccgt atttttcacg aagaatctgg atcgccgctc tttattcttt taaaatgtga 3455881 gtgttataat ttgtaatggg aatcagatca ctgttattca tggaatacta atggcaatct 3455941 tcttgataaa tatgaatgag cggggttaca aagtgagtat ttcttccatc cttttatcac 3456001 tttttttcat tttaaatatt cttttggcca tcattgtcat cttcaaagaa cggcgcgatg 3456061 ccagtgcatc ttgggcgtgg ctgcttgttc ttttctttat tcccgtttta ggctttattt 3456121 tatacttatt attcggccat aatctcagac gcaagcattt gtttcaatgg gaagaccgga 3456181 aaaagattgg aattgaaagg ctgctgaagc atcagcttga agatttagaa accaagcaat 3456241 ttcagtttaa caaccgggca acctttgata acaaagattt aatttatatg ctgattatga 3456301 ataaccatgc tgtgtttaca gaggataatt cagttgacgt cattacagat ggacgggata 3456361 aatttcagcg gctgctgagt gacatttcaa aggctaagga tcatatccat ttacagtatt 3456421 atatttataa aggcgatgaa ttaggcaaaa aattgcggga cgctctcatc caaaaggcga 3456481 aagaaggtgt tcaggtcaga gtgctttatg atgaactcgg gtccagaacg ctgagaaaaa 3456541 agttttttaa agagcttcgc gaggctggcg ggcatgtgga ggtctttttc ccgtcaaagc 3456601 tcaggccgat taacctgcgg ctgaattacc ggaaccatcg aaagcttgtg atcatagacg 3456661 gtatgaccgg ttatgtcgga ggctttaacg tcggagatga gtatctaggg cttaatccga 3456721 aattcggtta ttggcgggat acgcatatcc ggctgcaagg aacggccgtg cacgccatcc 3456781 aaacacgatt catccttgac tggaaccaag cttctcatca ccatacgctg acatatattc 3456841 caaatcactt tcctgattac ggcccaaaag gcaacgtcgg gatgcagatt gtcacaagcg 3456901 gccctgattc ggaatgggaa caaattaaaa atggctacat caaaatgatt tcgaacgcca 3456961 agcgttccat tttgatacaa acaccttatt ttatcccaga tgcaagcctg ctggatgctt 3457021 taaggatcgc ttgcctttcg ggcattgacg ttaacattat gattccgaac aagcccgatc 3457081 acgcctttgt atactgggcg acactttcgt atatcggcga tctgctgaaa gccggagcca 3457141 ctgtctatat ttacgataac ggctttattc acgcgaaaac catcgtggtg gatgacgaaa 3457201 tcgcttcagt cggcacagcg aacattgatg tccgaagctt caggctgaat tttgaggtta 3457261 atgcatttat ttacgatatc accattgcta aaaaactggt ttcaactttt aaagaagatt 3457321 tgctagtatc cagaaaattc acctatgagg agtatctgca gcgcccgttg tggattcgaa 3457381 taaaagaatc cgtctcgcgg ctgttgtcgc cgatcttata agatgcgtaa acccccggcc 3457441 tttacggccg ggggttttcc tgatggtcac agtaaatgat gattgcctcc cgcaaaaaag 3457501 cggcaagacc ttctccatat tgattgattg aatcggtaaa tcgctcgtca gtgatataca 3457561 cttccccgag tcctctgaaa atgtcgagtg tgcaatcgta atgatattgg caaatatgat 3457621 cgcgaaatgc ccccacagcg gcctgaatct ctgcatcatc gggcccatgc ttcattcgcg 3457681 ccgcaattcg tctgtaaatc gaatcaaatt cagccatgat cgtgcgccaa tcatctgccg 3457741 agtatgcaga tgtccttttc tctgtttctt ctgcgatttc ctttccatac agctttctga 3457801 cttcatcagc gtatgtctgc tggtgctctt caatgtcttt catgcttaat ccggcaaata 3457861 aatccctctt attcatcgtt tcccctccat caacggacaa aagcgtcctg tcaattgttt 3457921 gaatcatctc atccattctt tgttttttct tcatcaatat ctccttttgc gactgaagtg 3457981 ccgctttccg gtcaaaattc ggatgatcca gcatctcttt aatctcatcc agacgaaacc 3458041 cgatttcctt gaaaaataaa atctgttgca gtctttccag gtctgcgtca ctgtacaaac 3458101 gatacccagc atcagtaagc gctgaaggat tcagaagctc aatattgtca tagtgatgaa 3458161 gcgtccgaat gctaacgcct gatatctccg ccacttgttt aacttgatat ttcatacata 3458221 acacctcctc ttttttatcg taaacaatca cgcaacgtta gggtcaatcc ccaaaatgtt 3458281 attttctata tacaaaactt ctcacaaata gtgtataaaa gaaaagtgag tatttttttg 3458341 taaaggggag ccagtataca tgaatcctga aacaatgaac aaaaccctca tcagcatttc 3458401 gaaatgggga aaagctacag gcattttatt tattattatg ggcgcaatta ccgcgctttc 3458461 aggcgcgttc ttttttctaa tcggtgccgt gccaggcgta ctgcaaatta tttccggtat 3458521 ctttttgatg aggtcagcta gggaagcagg ccaaatggct gaacacaata gcggacagtc 3458581 tgaagactta atgctggaga attacgcgaa attcgtaaag atgcaaggga tttatttgat 3458641 cgtaagcatt gctgtatcca ttcttgcgat tatcgccttc ttcatctttt taatgcttgg 3458701 gattgctgac ggccttttca gcgatacgta cagcacttat taatgagaaa aacccggagc 3458761 tggctccggg ttttttatta ttccgcttcg cttaccactg tgaagcgttc atttttgtgt 3458821 tcgggatgtt caagctcgtc caacacggca atggcataat ctgcatagct gatatagctg 3458881 tctccttttg catttacgat gacattgtct tttccttttt ggtaagagcc agtccgtttt 3458941 cctgctggat caaaaaatgc cgcaggactg aggaacgtcc aggaaatgga gtctgtctgc 3459001 tgcaaatctt tcaggttctc gccttgattt gatgcagttg gcaaatattc tttcggaaat 3459061 tccggcgtat ccattaaacg ggttgttttg gcttcatcaa caaacaggct tcccgctccg 3459121 ccaacaacaa gcaatcttgt gtgcttcgcg tcctttaaaa tgctgatgag tgctcttcct 3459181 gcttcaacat gaagatgttc ttggccgggt gctgctccaa aagcgtttac gaccgcgtcg 3459241 aaaggcttga tgtcttccgc agtcagttca aacacatctt tttccaaaat cgctacgtct 3459301 tgctcctgca cttttgaagc gtttctgacg atggctgtca cttcatggcc tctttttttc 3459361 gcttctttca aaatctcgtt tcccgctttc ccgcttgcgc ctataatacc aattttcatt 3459421 tttcatttcc tccttatttg taacaatttt agttacatgt tagcggtgag aagtcatccc 3459481 ttttgattaa aagagatgat tcataacatc ttttaatgac ttgcttgcca gttcattttc 3459541 catcgctctt tgcacacttt caaacgtttc atccagagcg ttctgaattt ttttccctac 3459601 cggacatttc ggattcgggt tttcatgaac cgcaaagagt tcttcttgct tttggacagc 3459661 ccggtacact tctaaaagag aaatatcagc aggatctttt ttgaggcttg cacccggcac 3459721 cccggcgcgt gatgtgagaa tatcagcttt tttcagcagg ctgatcattc ttcgcacaac 3459781 taccggattc gtgttgacac tgtctgcaat gatttctgaa gatgtttttt catccatcga 3459841 gatgagggat aaaatatgaa tggcaacagc aagacggctg ttaatcatgt tttttcacca 3459901 ccgttgtaac tataatagtt acatttgatt cgtttgtcaa catctaatat acactaaata 3459961 catgggtttt gtgcaccgtt tttagtcaat agaacggccg gatgcactcc ggccgcgtct 3460021 tatcaaaata agaaatatct ttgtccaagt gggacataat cgacaggctg gcaagacaat 3460081 tcctccccgt cagcaaagac ctgataggtt tttggatcaa tctcaatctt cggcaaagcc 3460141 gaattcagct tcatatccag cttgctcagc tttctgatat ttttgactgg agaaatcctt 3460201 ttttccagcc ctaagctttc cgccacacca cgctctatgc ttgcctgaga cataaatgta 3460261 atcgaggttg agcggttggc ttttccgtaa gacgcataca tttggcgcat gaaaaccggt 3460321 tcaggagtcg ggatggacgc gttcggatct cccatttgcg cacgtgcaat catgccgccc 3460381 tttaagacca gttccggttt cacgccgaaa aataccgggt cccacagaac gagatcagca 3460441 agcttccctt tttccaccga gccgacctca tggctgagcc cgtgcgtaat tgccggatta 3460501 atcgtgtatt tggcaatgta ccgttttgcg cgcacattgt cattcccgtt ttcaccggca 3460561 agagcgccgc gctgtttttt cattttatcg gctacctgcc atgttcggat gatcacttca 3460621 ccgacccgcc ccatcgcttg ggaatccgat gatgtcatgc tgatcgcacc tatatcatgg 3460681 agaatatcct ccgcggcaat cgtcgccgcc ctgattctgg aatggctgaa tgccacatct 3460741 tcaggcactt tcgcatctaa atggtggcag accatcatca tgtcaagatg ctcatccatc 3460801 gtattaacgg tataaggaat ggttggcgtt gtagatgacg gcagaatgtt cgcgtaagag 3460861 gcgagcttca taatatccgg agcgtgaccg ccgcctgccc cttcaatgtg ataagtatga 3460921 ataacccggt ccccgatcgc gtcgagcgtg ttttccaaaa agcccgcttc gttaatcgta 3460981 tcggtatgga tggcaacttg aatatcagcc tcgtccacga cttccataca cgttttaatg 3461041 gcgcttggcg tcgttcccca gtcttcatgg agcttaagac cgatggcgcc tgcttccacc 3461101 tgctcgatca gcggcgcttt atcggatgca ttcccttttc ctaagaagcc gacattgatc 3461161 ggaaactcct cggccgcttc cagcatcctc gccatatacc acgccccgga cgtacatgtt 3461221 gtcgctttgc ttcctgtagc gggtcctgtt ccgcctccca aaagggtcgt cacacctgaa 3461281 gaaagcgcaa cttccatctg ctgaggacaa ataaaatgaa tgtgcgtgtc cactcccccg 3461341 gctgttaaaa ttttgccttc accggaaatc acctctgtcc ccgctccgat gaccatgtgc 3461401 ggatcgactc catccatgat atcaggattt ccgctttttc cgacaccgac aatccggccg 3461461 tctttcacac cgacatccgc tttgacaatg cctgtgtaat ccaatagcac gacgttggtg 3461521 ataaccaaat ccaaagcgcc gtccttccct gtgattctgc cgttttggcc catgccgtct 3461581 cggatagttt ttccgccgcc aaagatcatt tcttcaccgt atactgtgaa atccttttcg 3461641 acttcgatcc ataaatccgt gtcgcccaat ctgattttat cgcccgttgt cgggccaaac 3461701 agttccgcat attcctcccg tgacattttc atcggattac accctccatc cagccggctt 3461761 gttttaagtt ggccaacgtt ttttctttgc cgcgttcatc gataaacgtg tcggccattc 3461821 cgttcagccc tctaattgtc ttgcgtcctc tgatttccac tagtgagacc gttttctgct 3461881 ctcccggctc aaaacggacc gacgtgcctg atggaacatc aagacgcatg ccgatcgcca 3461941 gctcacggtc aaataataaa gccccgttgg cctccgcaaa atgaaaatgc gaaccgactt 3462001 gaatggagcg tgatccggtg ttttttaccg ttacctcccg tatctcacgg ccttcattaa 3462061 tcgtaatggt tccctcagca atttgaaatg ctcccggctt catgacttca cctccgcaga 3462121 aattggctga tgtaccgtaa caagctttac accatccgga aatgtggcct ccacctgaat 3462181 gctgtccagc atctcaggca caccctccat cacatctttt tccgttaata catggcggcc 3462241 ggcttccatc agctctgcta ctcccttccc atcacgtgcg ccttccataa taaagcaggt 3462301 gatataagca gcagcctcag gatagttcag cagaacgccc cgcgcctttc gctgtttggc 3462361 taattccccc gctgcaaaaa tgagcaattt ctcttgttca actggtgtca gtttcatctg 3462421 tagtcctcct tcttttgtca tataaagcag atgcggctac tacgaatttg cggaacagtc 3462481 aggcgggaca tcacctccct ttcttcgaga atgggggtca tacggtaaga tgcctttcaa 3462541 agcggcatgc cgtttcttca tcagccttgc catggtcaac aaccgttccc ctgtcgatca 3462601 cggaaagatc agattaacgc gttttccaga ctgcgctcga ctaagataac aaatgtcttt 3462661 ttttctggaa atttctataa taacttgtct gactagttcg acaattaaaa tctgaattcc 3462721 ttccaattgt ttattaagta aaatattttt cagatttacc atcagcgctc tggtgattgc 3462781 aagctgctgc tgttgaccgc cttttcgttt tgaacaaacg tttgattaaa acaaatagcc 3462841 ccctctgttt agccggagtc ggcctaatac agcgacaatc tgccccgggc gaagctaagg 3462901 ctgtgcaaaa ccatcgattg atcataacca gacgttacat tcctgatggc agcccgttgt 3462961 tttgctccgc aaccggaagc atggcatgga ggccagtctg aggcgccgac ctccacgata 3463021 ccgagaaccc gactattgcc attaactccg catcatggac ggtcacttcg ctgatcgcca 3463081 ccgttcctct taatgagtga agaattccgg ccttcactga atccccgctt gtgtcgatat 3463141 caactgtttt ctcgcactcc cgtggcttcc gacactttct tcggtgcagt acattccgtc 3463201 atcaaaaccc ctttgtttga tttcttcaaa tgatgttata aaagtttaca acttatgtca 3463261 tcattatata gaagaggcct attaattcaa agaatattta aaaaatttag ttaccttgac 3463321 caaatcagct tctttttttg ttatatttat tcacatcaga aaaagcgaaa aaaaagacaa 3463381 gaaacatttc gtttcctgcc tcttccgtac gattaatctt tatctgaaaa tttatccttg 3463441 gctttcccga tatccttttg gatttcgcct tttgccttat cttttttgcc ttcagcctgc 3463501 atgtccgttc tgtcagccat atctccgact ttatccttca cttctccttt ggctttattg 3463561 aagccgccct tcattttgtc ttttacacta tcgttaccca tgttaattct cccctctcaa 3463621 ttatgtgtgt acttgttaac ttcccgatct gagaggcaat aaacattcta atgttattta 3463681 tcgatttcgt agcgctctcc gtaacggagc accttgtata tcgccagccc gtctgatgac 3463741 tttttctccg aatatcggac cggcagcagg gcaaaaaaca cataatacgt agaaaaatag 3463801 acaaactgat agaaaaacac attcggcttt aatacactgt gtataatcag cagattgatt 3463861 gcaaaaatcg tgatgaggtt aaacaagcag ccccctgcat acacgagtgc atttgagaat 3463921 cgattgtcaa ttttcaactc cccgtaccgg caaaaagaat cgataaaata aatcgttctg 3463981 aaccgtatgg gtccaatttt aagcagcgtt tttcccatgc ctatatccaa cgatcccttt 3464041 ccgccaaaaa taaaagccat aaagctgtgc cctgaaacat gtataatctg tacaagcggc 3464101 agaacaatga ggaaagacca cagaaacttc accatatcat taaaaccaaa cattgaattc 3464161 cccctcacat gcatatctgc atcccaaaac ggcttttgtt caaaaaacag tgctgtagcg 3464221 atttttcctg ttctccccgg aaataaacgt tccgatgctc cccttttttt gcataaaaaa 3464281 aaaccatctg ccagcagatg gttttgtctc atacttcata taaacaatcg ttcctttgaa 3464341 tcatctctct catgctgacc gctttttcat aaaaatacac cgcttcttta tattgttcgc 3464401 gatgactgaa ataagaggca gcatctaaag caaattcttc aatatataca tacaggccct 3464461 tttcttccat ataatcaaat acttcttgaa tcatattcaa attgacagat tccacatata 3464521 atgcctgcag aaatttatat tttgccagac tgaagaagtc gtttcgtttt tgggcaatgg 3464581 caatcccttt ttcatagtac cgtatcgcgg cttcgctatc ttgttttttg aaaagaacgc 3464641 gagtcaggct gaagagcgct tttggaagct gttccagctg ataatcctcg aagacaggaa 3464701 gcgctttttc aaagtattcg gcggcctgat ccagctcccc cttgtcatca tagcaattac 3464761 caatattata aagggctgat ccgatcaaac ggggctgtcc ttccaataaa gcaaggcgat 3464821 acgcgtcatc taaatgttca agcgcttttt cataatttct gtagtcaatg tagtttcctg 3464881 atatgacgaa atggcattga attcttctga ctctgtaaaa atcgtgagcc ttatacgtct 3464941 ccagcgcctg tacggcatgg ttcatggaaa agtgcgtctg cttcataata taaaagactt 3465001 ccgccacttt aaaatgaaat tccgctcttt caatttcatc ttctacaaac gcaagcatct 3465061 tctcagcttt ccgataaaag gatatagccg agatgtaatt gttctgttca aattcgtaca 3465121 ttcctctaaa caagtgaaaa taatactcag ataatccgga gatgctgtcc tgattgcttt 3465181 ccagcgtttt gatcaattca cgatattgaa gctgagattc ctcgtgcagg tcaggcttta 3465241 cataatccag cataatttgg tgccggtagc tgatcagctg ataatacagg agaagcagct 3465301 gatcctcttc catctgttcg atatctagat caatttcttc tttcagtttt acggcatcag 3465361 ccacttgaaa tgctaaaatg tgcttatacc acttattgat tttcactcct acttgagatg 3465421 acgggatctc gtacgcggcc atgcccctcc aaccctttct attttctaat tggttatatt 3465481 ttatcataat gtatggcttt ggaattaaat tttcttacaa tgattccttc tttatgccta 3465541 tccttatata tttcggtttt tctacgtatt ttttgcactc ggattctaat aaaaaagctt 3465601 accggacagt gccgataagc ttttgacttc aaattaaccg ccaatataag acatttccac 3465661 tttctttttg ccagatgctt ttgatagcgt acgatcgact gaatactgat cgatccgatt 3465721 tttccatact gtcccgatca tttctgatag ttcgtcatca cttaattcct ggcgaaccgg 3465781 agctctgagg tcaaatccgc ttgaagcgaa taagcaggta aacagctctc ctctcgcaga 3465841 aagacgggct ctgttgcaag atccgcagaa tgcatcagat acagatgata tgacgccaat 3465901 ttctccggag ccgtccaagt agcggaatct ggaagccact tcgcctatat aattaggcgc 3465961 tatcggctca accggcatgt gtttattgat caaatctatg atttccgcct ttgtcatgac 3466021 gtctttcttt tcccattggt tggtgttgcc tacgtccata aattcaatga atctcaggat 3466081 atgccctttt tctttaaaat aacgggccat aggcagtata tctttttcat tgacgccctt 3466141 ttgaacgacc atattgattt taacaccgag ccccgcttgc ttcgccgctt caatgccttc 3466201 cagcaccttg ctgacagaaa caccgcgccc gtttatcttc ttaaaacgct cgtcttctaa 3466261 agaatcaagg ctgatcgtaa cccttttcag cccagcctcc ttgagcctct tagcataaac 3466321 aggcagcagt gatccgtttg tcgtcatcgc gatgtcacga atacccggta tgcgggccag 3466381 ttttttgatt aattccggca tatcctttct catgaggggc tctccgccgg tcaagcggat 3466441 tttttcaacg ccaaatcttg tgacaaacaa tgtcgcaagc cgttccagct cctcaaatga 3466501 aagcagctcc tctttcttta aaaaaggata atccgggccg aataattcgg cgggcataca 3466561 gtacgtgcat cggaagttgc agcggtctgt aacagaaatg cgaaggtctc tcagcggtct 3466621 gtttctttta tccaacatct gacgcgactc tgtaatcata gctacagccc cttcctactc 3466681 cctgattctc tcagggtgtg tatatacatt aaatgatccg tttctgacaa atccaatcgc 3466741 tgtgatattc aattcttcag ccatttgaat cgcaagctcc gtcggggccg atttggaaat 3466801 gacaatcgac acgccgattt tggccgcttt taacaggacc tctgatgaga ttctgccgct 3466861 gaacacaatc agtttgtcgc gtacggacat cccgtttaga aggcagtgtc cgtatagttt 3466921 atcaagtgcg ttgtgccgac cgatatctgt gcgcatcaac agaagcttct ctgtgtcgca 3466981 aagcgccgca ttatggacgc ctcccgtatc ctgaaacgtc ccgctccctt gctgcatgtc 3467041 tttcataagc gccagacatg cctcaggcga tatcttgatt tggctgacag ccgtcttggc 3467101 tgttttgaca tcctgctgaa aataaaaatg acggcccttt ccgcagcatg agccgatcac 3467161 ccgtttcgta taatcctttt gatccaatgt ctcagggtga acgaggtcga catatacaaa 3467221 accgagactt tcatctattg taaacctttt aatttctttt tgaaatcgta taacaccctc 3467281 tgatgcgaga aatccgatga caagctcttc gatatgctca ggcgtacaaa cgagcgtcac 3467341 aaattcactg ccattcagta tcactgtcaa agggaattcc gtcaccatcc ggtcttctac 3467401 tttgcttatt tccccttgtt catagcgcca tacatccctg accgcagtta ctttatcgtt 3467461 caatgtctct tcccctccgc aatgttcctg cctttatatt ttttcacact cctcggattt 3467521 tgtcgaattc tgagacacaa aaagagccct ctatataaag ggcttttaca ggatgtgatg 3467581 acggcggtgt ttaggcagga cgcctaagca tttagccgcc gttcctttta taacacgtga 3467641 gcaccaatgt gcattgacaa cgaacgcggg gtttgtcgac acgctgagac acctctgtat 3467701 aaaggactct atgtttgatt atgctgattc tttttcagaa ccgtaaacag cacaatagct 3467761 gcgatcaagg tgagaatgct gacaaaaaag aaggctgcca gttttagaag aacaccaagc 3467821 aatataaatg caacggtggc tataagaaaa atcattccga ataatttcat atgttcaacc 3467881 cctttttagg gtatcattcc cgcccaaact gtttttaaac caataaaaaa ggcgcctggg 3467941 ggagcgcctg atctttaggt tccttactca gtaaattttt gtgcttcttt ttcccaagcc 3468001 tgttcgaact catccgcact gttcgctgaa atatattctc cgccgccagc gacagctgct 3468061 tgtttcatct cttcattacc cttgacatca aagttgaagc caatgatgtt tacaatcgta 3468121 tccacatttg atgcacggag cttttcgatt tccgccgcag ggtctccgcc gcacgtttct 3468181 tcaccgtcag tgattaaata caccacgttt ttcccgtctg cgtcaaatgc ttcaaattct 3468241 tttcttgtgt ctgcaagtgc tttggcaatc ggtgtccatc cagtcggctt gagctcactc 3468301 aatgaattgt caaacagaga cccttcatat ggatgaaggc cgtaaatggt ttccgtcgta 3468361 ctgcacgaaa gggctttacc ggacagttta ttgttccctg catgcccgaa aacgcgaagc 3468421 ataagatttg tatcctttgg aagaagttcg gcaaaagatt ttactgattt tttggcaatg 3468481 tctattttgc gctctcctcc tgttttttga accatgcttc cgcttccgtc aaacaaaaca 3468541 gctacatttg tatcagcctg tttctcagcg gcaaaagacg gggaggcaat ggaaacagtc 3468601 aacaatccaa tgataccggc agccagcaat tttttcatat gattacttcc tttctttttc 3468661 atattttcca actatatgtt ggattcttct ttatgctaga atacgaaaat gcaaaaagat 3468721 ataggacatg ctgccttttg tgctgctttc acgatctgtc caaaatcgct tgaaatgccg 3468781 ttcattttta gccatttccg cccagaaagc ataaacagct tgtgtgatca ttcattcttt 3468841 tttcgccttg attatgacag aaaaacggaa atctgctact atgctacagg cagacagcta 3468901 attagttttg aagtttttgt tacatacaaa aagaggctga ccatcaccag cctctttttt 3468961 cttatttaga taacattagt gattgctgag tgaaaatttt ctcaacatct ttttgggtat 3469021 aagccgggaa gtattcaccg ccgcctactt tcgcaattgc gttcagctgg cctttgtatc 3469081 cctctttata atcaaagccg atcacattaa cagtgatatt gtctttttgc agttcctttg 3469141 ctgttttaat cgggtttcct ccgcacgttt cctcaccgtc tgtcaacaga tacaccactt 3469201 tttccccttt tgcatcaagc tggtcaaaag aagatttcgc ctcgttcagc gctttggcaa 3469261 ttggcgtcca gccagtcggc ccaattgtat tgagagaatt gaggaagctt tgctcgttaa 3469321 agctttggaa gccgtatacg ttgcgaatgg cttcacatga ctgaactttt ccggaatttt 3469381 tattgtttcc ttcagagcca aacacgctca ttttcacctg agttccttct ggcaatgagc 3469441 tcgcaaactt tgaaatttct tttttggctg aattaaattt agatacacca tctattcttt 3469501 tcgccatact tccgctggca tcaagcaaga ccgccacgtt cgccggcgct ttagcctccg 3469561 tttctgtctt ttcagctgca aaagcaggtg aagttaatcc aaaaagcaat cctgtcatca 3469621 tgatcagtga aaatcttttc ttcatgttcg taccccttta ccaatttgtt tctgcgtgca 3469681 gatgttcaac gctgaacata atctatcgta atcaacaaaa accgagaaat aaatagggcg 3469741 ggcttcccca ttgctgttgt ttacttttgc atagaaacct atgtttttat tagtgatttc 3469801 cacctaacgc ccctatgaaa agagaagatt gtccgccttt cggctttcgt tatatgagtc 3469861 tgtcgaagtc tgtcgacaaa tgtggatgac tttaccacaa tctcaaagcc tgaaatcagg 3469921 aaaaaaggac tgatccttaa agacggtcag aagctcctct aaaccgtttc agctactctt 3469981 agataaaaga tattcaggaa cagaaaaaga cgcccaatga gcgtcttttt ctactttttc 3470041 gccatatatt tattcaaaaa cgcatctgcc tcagaaattt gtgtgccttg gtaatagtac 3470101 tttacaatgt catcaaccgt tttgccttct ttggccataa aattcgctcc gtattggctc 3470161 atccccacac cgtggccaaa tcctctcgtc gtgactgtaa ttgtgtctcc atttcgcttc 3470221 cattcaaaat cggcggagtt gagacccaac ttttcacgta tgtctcttcc tttcagcgtc 3470281 ttgccgttaa tgacggcagt tgcgacctgg tggcccggtg tctcgccggt aatcttccct 3470341 actgcgctag atccatccag cttgacgcca agcttttgct gaaattctgc cgctgtaaag 3470401 gttttcgttg ccttatattt cggagacttt ttatcccatg ggcttttgac gctttttaaa 3470461 tatgggatag cacttgtcca ataagcttct gcattctctg tgtagccgtt gcttgtggag 3470521 aaaaaggatg cttcaatcgg ctggttgttg tacgttaaga ttttgccttg cgtactggct 3470581 accgcatctg tgattttctt cagttttgtc tcatagcttg tgccccactg ttttttcagc 3470641 tccgctttgc ttttatacac ctggaacatc tgtgtatcat ccaccagtga gcctttagga 3470701 gcttctaccg ctgaatttga caccatcagt ctgacaataa atgttctggc ggcaagcgcc 3470761 tgggctttca gcgcttcagg tttaaaggtt gccggcattt cggaggcgac gactccaatc 3470821 acatactctt caagcggaat gttttctacg gattgatttg cggttcgata gacgggaata 3470881 gaaacaggtg atgctttcaa tgtttctgct cctttcgatg ctggtttcgt gctgactgct 3470941 gtcttttctg attctacgct ggcccccgct tccttattat gctggaatgg tataaccaag 3471001 agtgtgggaa ccaagagaat caatgcacat agtacggata gtgtgattgc gaattgtttc 3471061 atattcagct gcctcctgct cgggattcga ctctagtcta gtctatgggc agggacaagc 3471121 taatatgact ctcgttttgg acagaaactt tatttgtcat ttacgtattc ttttttgcta 3471181 ttttgcgcat aatgatgata atacacaaaa aataaaaaac cagtatgcca gagtgacata 3471241 ctgattttca agtaagttta tgcatttaag tcagaaacga cttctttatt ctcttgctca 3471301 gaagcagact catcatttac acgttcgatg tctgcgccca gagcggcaag cttctgatgg 3471361 aaatcaacgt aaccgcggtc taagtgcttc aattcagtaa cacgtgtgtg accttcagcc 3471421 actaaccccg caagaatcag cgctgcacct gcacgcaaat cagtcgctgc aacttcagct 3471481 ccctgaagct gtacaggacc gttaatgatg acagaacgtc cttcaatctt gatatcacca 3471541 ttcatacggc ggaattcttc cgcatgcata aaacggtttt caaaaacggt ttctgtaatc 3471601 atgcttgtgc cgcttgcacg aagcagaagc gccatcattt gtgactgcat atcagtcggg 3471661 aagcccgggt gaggcattgt tttgatgtca atcggtttaa gctctttcgg gccgatgaca 3471721 cgcagacctt caccttcatc cttaattgtt acacccatct cttccatttt tgcaattaaa 3471781 gaggtgaggt gctcaggaac cgctcctttt actaatacgt ttccttcagt gattgcagca 3471841 gcaaccataa atgtgcccgc ttcaatacgg tcaggaataa tatggtgttt tacgccgtga 3471901 agcttttcga ctccttcaat tttgatggtg ccggtgccag ctccgcggat ttttccgccc 3471961 atgccgttga tatagtttgc taaatcaacg atttcgggtt cttttgccac gttttccagc 3472021 gttgttgttc cttcagctag agcggctgcc ataatcaggt tctctgtagc tcctacactt 3472081 gggaagtcca gataaatttt tgcgccttgc agtcggcctt ttacttcagc ttcaatgaag 3472141 ccattaccga ctttgatttc tgcgcccatt gcttcaaaac cttttaaatg ctgatcaatc 3472201 ggtctggaac caattgcgca tccgcccgga agtgcaactc ttgcatgacc tgtacgcgca 3472261 agaagcggcc ccatgacaag cacagacgca cgcattttac gaacatattc aaaaggtgct 3472321 tcagtttgca aagcgtatga agcatttaca gtcacttcat tattttcaaa atgcacatct 3472381 gctcctaaat gacgcaacac ttcgttaatt gtatatacat cggagagcgt aggtacatca 3472441 caaattacgc ttttttcttc acttgctaat aaagatgcag cgataacagg taaaacggca 3472501 tttttagcgc cttcaacttt gactgtgccg tttaacttct gaccgccgcg gacgatgatt 3472561 ttttccaagg tattcccctc cgcgtcccta aattctctat attaatattc agtcgtaacg 3472621 attggtgtgc caaccgtaac ggtatgtttt ccgcccattc ctgcacttct aagtgcaatt 3472681 tgcaaattca ttttatgttt cgaggtcata atgtactctt cccactcatc tgtaaacgca 3472741 gaaatagaaa cgaaatttgg ctcaactaca tgttctactg atcttgcttg aaattcattt 3472801 aataactgat ttgctttttt ttgcaaaaca atattcatat tatcatctaa gtgaccattt 3472861 agacaagtaa aaataactac tttttcttgg aatatcccaa gtgtctcccg ttcaaactgt 3472921 tcatatgtat cattccagct atccggtgtc tctagactca tttgctcata taataaatac 3472981 gaagttggat tgtgtttttt gagggttgtg acaagctgca gtctaaaaga agtacgattt 3473041 tttttgtcag tatatgtgcc aattgccttt atcattttat cttcccgtgc aatcacccaa 3473101 tcatattgac gatactcttg ttttaaacgt tgcacttttt gataaaattc tttttcggtc 3473161 agtgacaagt tttgttttgc atgcaatgtc cacttatcta ttgacacatc ttgacgttcc 3473221 atcccctctg ccatctgtgc taacggcgtt aattcactcg catgaatggt atggaaaaca 3473281 gcaatgacga agcttaacat gacggaaatg ataatagcgt ggcttacttg ttttttcttc 3473341 atgttcatct ctccccctta tccccagttt taccggaggc aagaggcgcc atacgtaaaa 3473401 atcttcgtca aaactcgagc tattcgcttc aacccgcttc tcccaaccat ttaataatgt 3473461 tcaaaaccta ttaaaataga tagggaagct gctgtgaata attgaggtaa tctaaaaaga 3473521 aattggcaac ggccgttcca atggcgattg tcagcaaaat catcaggagt cttgcctgca 3473581 cgactttgcc ttttttgatt aacggatcta tattgacggc ttgcaacgcc caccaagtca 3473641 ctgctataaa aatcaggtga acgacaatgc cgattgcagc ctgctgtccc aatacactca 3473701 tctattacac tcctttctct gcgttcatac cctttcttat tatataagaa gcacagataa 3473761 agatgataca ttttatacag aacggaataa tcagccaaat ctagggctaa tccccgctta 3473821 aagtgcgatt cttttacatg gtatacttta ttggaaagga gctggcaaat gtgaatcatt 3473881 ctttttttca gcctgaaaag caatatggtg aggacctgcc aatttttgat caggaatggg 3473941 aagcaattgc attctattat gattatagac agtcacagat tgaagaactg aatgaattgt 3474001 gtcagttttt taacatttct cttacctata cgagagaaag ccttgaagag cttgaaaacc 3474061 tctattttca aagtatacaa gaacttttgc ttgctgattg gaatcttcct attgaagaat 3474121 tcgagaaaat gatcagtgtt tatcttatag attgtgtgat tgcccgccat gaagatgctg 3474181 aatgggttgt aaaaccttat ccctataaag acggcgctta tacacttggc tttagaagac 3474241 atcgcaaatc gtggcataca atgaatgcct gtgatggttt atacctgcgt ccaaaagagg 3474301 atcgcccgtt gctgtcgctg tttgattctc ttgtgcgttc ataaaaaaat ccttctcata 3474361 aagagaagga ttttttctta tttccctgct acatccaatc tgttcaaagc ccgctgtaac 3474421 gcaagctcag cccgacgaat gtcagtatca tctgattgag aattcaaacg ctcctgcgcc 3474481 cgctggcgtg cagcttcagc gcgctcttta tcgatgcctt ccgctgtctc ggcagcctgg 3474541 gcaaggatgg tgacatgatc aggacggact tctacaaaac cgccgctgac ggcaaccatt 3474601 tcagtctgcc cgtctttttt cagacggaca gcgccgattt taagaggagc cacggttgga 3474661 atatggcctg gcaaaatacc gagatcgccg ctttcggctc tcacactcac catttcgata 3474721 tccgcatcgt atactgggcc gtcgggagta acgatattga ctttaacggt cttcatgctt 3474781 ttaccctcct aggaccagat taaacttcta cacccatttc ttttgctttc tcaacaactt 3474841 cttcgatacg gcctacaaga cggaatgcat cttctggaag atggtcatat ttaccggcta 3474901 agatttcttt gaagccttgt accgtctctt ttacaggcac gtaagaacct ttttgtccag 3474961 tgaactgttc agccacgtgg aagttctgag aaaggaagaa ctggatacga cgtgcgcggt 3475021 gaacgacaag tttgtcttcc tcgcctaatt catccatacc gagaatcgca atgatatcct 3475081 gaagctcttt gtaacgctga agcgttgact gtacttcacg cgcaaccgca tagtgctctt 3475141 ctccaacaat ttcaggagca agggcgcgtg atgtagatgc caacggatca accgcagggt 3475201 aaatacccat ttcagttaat ttacgctcaa ggtttgttgt cgcatccaag tgagcgaacg 3475261 ttgtcgccgg cgccgggtca gtgtagtcat cggcaggcac gtagatcgcc tggatagatg 3475321 taactgatcc aacgttcgta gacgtgatac gctcttggag ctgacccatc tcagttgcaa 3475381 gcgtcggctg ataaccaacc gctgaaggca tacggccaag aagggctgaa acctctgaac 3475441 ccgcttgtgt gaaacggaaa atgttatcga tgaagaacag tacgtcctgt ccttgtacat 3475501 cacggaagtg ctcagccatt gtaaggcctg tcaaagcaac acgcatacgt gcgcccggcg 3475561 gctcgttcat ttgtccgaat accatggctg ttttgttgat tacgccagag tcactcattt 3475621 cgtagaaaag gtcgttccct tcacgagtac gctctcctac gccggcgaat acagagatac 3475681 cgccgtgctc ttgcgcgatg ttgttgatta attcctggat taatacggtt ttacctacac 3475741 cggcaccacc gaacaatccg attttaccgc ccttaatgta aggagcaagc aaatcaacaa 3475801 ctttaatacc tgtttcaaga atttcaactt ctgttgaaag ctgatcgaat gaaggcgcct 3475861 gtctgtgaat cggatccttt ttcgcatccg caggaaccgg ctcattcaaa tcaatatttt 3475921 ctccgagaac gttaaataca cgtccaagtg ttacatcacc aaccggtact gagattggcg 3475981 ctcctgtatc tacagcttcc ataccgcgct gaacaccatc tgtagatgcc attgcgattg 3476041 tacggactgt atcatcacct aaatgaagag cgacctcaag cgttaaatca atacctactt 3476101 cgttttcact tgcagctggc tgtgaaattt taatcgcatt ataaatttca ggcaagtgac 3476161 cgtcttcaaa acgcacgtcg acgaccggtc ctaatacctg gctaacgcgt cctttcttca 3476221 tcgctatccc tcctgacaaa atctttctat tctaaagcgg ctgctccgcc gacaatttcc 3476281 gtaatttctt gtgtgatggc tgcttggcga gcgcggttgt aagaaagcga aagtgaatcg 3476341 ataagttcct tcgcgttgtc tgtcgcgttt ttcatcgccg tcattcttgc agcgtgctca 3476401 cttgctttac tgtcaagaag cgcaccgaag attaagcttt ctgcatattg aggaagcaaa 3476461 acctccagaa cctcctcttc agatggttca aattcataag acgccgttct ttttccgccg 3476521 ccgctgccca aatcagataa cggcagaagt tttttctccg ttacttcttg agtaatggcg 3476581 ctgacaaaat ggttataaac aaggtgcaat tcatcaaacg caccgtctat aaacatttga 3476641 atcgtttgac gggcaagatc tttaatttct gtaaacgtta cttcatctcc aagtcctgtt 3476701 aactcggaaa tgatcggaat ctcccgtttc ttaaagaaat cacggcccac tcttccgatg 3476761 gcaatcaccg catactcatc cttagactga tgacgttctt gcatggcctg ataagcactc 3476821 cgtaaaaccg aactgttaaa agcgccggca agaccgcggt cagacgtaat gacaaggtat 3476881 gccgtttttt tcacttctct gctgagaagc atcgggtgct tcacgttgcc ggaaactctt 3476941 ccgacgtttg acacaacctc ttggatttta tccatatatg gcacaaatga ttttgcattg 3477001 ttttcagcac gattcagctt agccgcagat accatctgca tggcttttgt aatctgactt 3477061 gtttttttcg ttgacgtgat ccttgactta atatcgcgta atgaggccaa agatttcacc 3477121 accttttctc ttcatctgcg taaaaagaga gaaaaagaga acctttttct ctcatcagca 3477181 ttcgagttag ttgcttggtg caaatgtgcg tttgaagcct tcgattgcag ctttgaagtc 3477241 ttcatcagca ggaaggtttc ctgttttcgc aattccgtca agcaggtctt tatggttttg 3477301 gtcaaggtac atgtagtact cttcttcaaa acgtctgata tccgccacag gaatatcatc 3477361 gagatatcct tttgtcagcg cataaagaat agctacttgc ttttcaaccg gaagcggctt 3477421 gttcagatcc tgcttcagca cttcaactgt acgcgcaccg cggttcagtt ttgcctgagt 3477481 cgcttggtcg aggtcagaac cgaattgagc gaatgcttcc agctcacggt atgacgcaag 3477541 gtcaagacgc aaagtacctg atactttttt catcgctttg atttgcgctg agccgccgac 3477601 acgggataca gacaatccgg cattgatcgc tggacgtacg cctgagaaga acaaatcaga 3477661 ttgcaggaag atctgtccgt cggtgatgga aatgacgttc gtcggaatat aagcagagat 3477721 atctccggct tgtgtttcta cgaacggcag agctgtaatt gatcctgcgc ctttcgcgtc 3477781 gctaagcttt gctgcacgct caagcagacg ggaatgaaga tagaatacat ccccagggaa 3477841 cgcttcacgg cctggcggac ggcgaagaag caaggacagc tcacggtaag cggccgcttg 3477901 tttagaaaga tcatcgtata caacaagaac gtgcttgccg ttgtacataa attcttctgc 3477961 cattgtaacc ccagcatacg gtgccaggta cagaagcggt gccggctgtg acgcagacgc 3478021 cgttacaaca attgtataat caagcgcgcc gtgtttacgc aatgtttcta ctacgccgcg 3478081 gactgttgat tctttttggc cgatcgcaac atatacacag atcatgtctt ggtctttttg 3478141 gttcaggatc gcatcgatcg caacagatgt tttacctgtt tgacggtcac cgatgatcag 3478201 ctcacgctgg ccgcggccga ttggaatcag tgcatcgatc gctttgatac cggtttgaag 3478261 cggttcatga acggatttac ggtccataac gcctggtgca gggctttcga tcggacgagt 3478321 tttgcttgtc agaatcgggc ctagtccgtc aaccggctgg cctagcgggt ttacaatacg 3478381 gccgattaac tcttcaccaa caggaacctc catgatgcgg cctgttcttt ttacttcgtc 3478441 tccctcacgg atctcactga aaggtcctaa gatgacgata cctacgtttg attcctcaag 3478501 gttttgagcc atacccaaaa caccgtttga aaattcgaca agttcaccgg ccatacagtt 3478561 gtcaaggccg tgcacacgtg caataccgtc accgacttgg atgactgtac ctacgtcttg 3478621 aacttcaata tcagattgat aattttgtat ttgctgtttt atcagcgtgc taatctcttc 3478681 agctttgatg ctcacttagg tttcacccct tctatcgatt ttccccggct aattgacgtt 3478741 caatgcgctg aagcttcccg cttacgctgc cgtcataaat ccggtttcca atgcggactt 3478801 taataccgcc tattaaatcc gtctgcactt catttctgat tctcagtgaa gcgactccgg 3478861 ctttttttgc aaacacttgt gataatggta acatttctgc atccgtcagc ggtttcactg 3478921 aatatacgat tgcgtcttct gtttgacggg ccacatttgc gagtttgata aactcatctg 3478981 tgagctcagg gacaatcgcg gcacgatggc ggtcaatcaa aagaaaaatc gtattgagta 3479041 cggactgtga caaagagcca aatgcatttt gaatcagctc ttttttcttc gcagccggca 3479101 ccttcggatg gttcaacaca tcattaagcg ctttttcatt ttgaaatact tgttttacaa 3479161 caattagctc ttcttctact tgattcagct gagcggactc attggctata tcaaaaagag 3479221 ctgatgcata tcgtttagag acagctgatc cactcatcgg ctttctccta cctctttaag 3479281 atagtcctgg atcaatttct cttgcgcttg ttcatccagt tctttttcga tcactttcga 3479341 cgcaatcatg acagaaagag acgctacttg ctcacggaga gcagaaaccg cctgttcctt 3479401 ttccttcacg atttcagttc ttgctgcttc tttcagacgt tcagattctg cacgtgcagc 3479461 ctgaataatc tcttcttttt gcttctctcc cagtttcttt gcgttttcga taagagtttg 3479521 ggattcctgt cttgcttctt ttaaaagaac gcgctgctct tcaatcagct gctgcgcttc 3479581 tttatttttt tcttcagcag acgtaatttc tccagcgatg tggtcttcac gctgtttcat 3479641 tatgtttaat agcggcccta aagcgtattt cttcagaagc gctaataaga ttaacatagc 3479701 taacagttgg aacaggatat ctccgccgtt aaacgacaat cctagttcaa gtggtaattg 3479761 agacatctac tacggcaact cccttctgca ggtttttctt tgctgatcca gcagccgcac 3479821 ttgtctcttt tcagccggca aggcgggatg cttatcagac ataaagcaat ggcgaaggtt 3479881 ctcttggaat gatcttcgcc atttttagtt catataaggc ttttatgctt agccaaagaa 3479941 cgctaagaat gcgataacga cagcgataat aggaagggct tcaactaatg cgatacccat 3480001 gaacataaga gttctcagtt ctttacctgc ttccggctga cgggcaatcc cctctaccgt 3480061 acgtgaaaca atcaaaccgt taccaatacc tgcaccaagt gcgcctaaac caattgcaat 3480121 cgcagctgct attaaattca tgaaaaagtt cctcctttaa aatgttatcc gtttggatat 3480181 aatgttttaa tgatcatgac tgattttatg agacatgtac accatcgtca gcattgtaaa 3480241 gataaatgcc tggatagcac caataaataa actgaatgct tgccatgcca gcatcggcag 3480301 aatggcaccg attgtaccga caagaccgag agccacgctt tgcgaataat ggcttgttgc 3480361 taatcccgca agcaggccga gaagaatctc accggcgaag atgttaccat acagccgcaa 3480421 acctagagtc agcgtattcg caaactcttc gatgattttc atcgggagca tgaatggaac 3480481 aggtcttaaa tagtctttgg aatattcctt gagccctttc atcttcacac catagtagtg 3480541 ggttaaagca acaaccatca cggctagcgt taatgtaatg gcaggatcgg ctgtcggaga 3480601 cttccaccag agctcatgtc cgattgtaat agagaacggc agccccagca tattcgacac 3480661 aaatatgtac atcagcaatg tgacaccaag tgccaagaag ttagcccctg tttttaaatc 3480721 cattgtactg ccaataatat tgcggacgaa atcaacaatc cattccataa agttctgggc 3480781 ttttccggga cggatcgaaa gcgttcttgt cgtcaatata gcaatcaata aaacaatcac 3480841 actcgccaca gtaatcatca gaatgtttgt cagattaaaa gtaagaccta gaaattctat 3480901 agttctgtaa ccatgattca aagggttttc acctctcttc cattgatgaa cgtttaagct 3480961 ggataaagga atctatcata atgacagggt atattgtcat taatccaata actgtacttg 3481021 ccatatgaaa gtattcggga tttttatagg caacagccac agcaagaatc gcattgcacc 3481081 accgcgctgc gctcccgaga gatcgtatgg actttccttt ctctacagct ctgtcaaaag 3481141 cattcattct tctgacgagc agtaaaaaat taaacaaact gaaaacagtt cccagaataa 3481201 ggcctaaaaa aacggtttta tacgctgtta aaccataacc cagtacatac actgccaaaa 3481261 tgaacaataa atatttgcgt tgtctgctaa atgtaagctt gggatcgtcc atcaattatc 3481321 tgtctcctga tgaaaaaata atgtatagct tggatacggc aaaaatcagc ggttaaccct 3481381 tagtagaaga ccttttttga ccggcaaaac gggcctgttc gaaaaaatca ttcatccgca 3481441 agccttgcag ggatgctgtt tcattcgctt aaataaatcc tcataatacg ggtttgctga 3481501 gaggatttac attgaggatg aggactataa tgaaagctat gaaaaccttc tcataatacc 3481561 ctcgtttagc atacaatagc ccctaacatg tgtcaatctg tttaaagtta aaaaactttt 3481621 tatactttac gtctccacag aatgttcaca ttttcaccta taattgtata cagattcacc 3481681 gaatagcaaa aaactggata aaaaaatgaa accccctttt ggggatttca ttttttattt 3481741 tgttccaaac atgcggtcac ccgcatctcc gagacctgga acaatatatc ctttttcatt 3481801 taatttttca tctagcgccg caatgtaaat atcaacgtcc gaatgatgct tctgcaattc 3481861 ttccacaccc tccggcgctg ctacaagaca catgaaacgg atatttttcg caccgcgttt 3481921 tttaaggctg tgaatggctt caactgcgga accgcctgta gcgagcatcg ggtcaaccac 3481981 gatgaattca cgctcttcca catcagaagg aagcttgaca tagtattcca cgggttttaa 3482041 ggtttctgga tcacggtaaa ggccgacatg tcccactttt gccgcaggaa tcagctttaa 3482101 aatgccgtca accattccca atcctgctct gaggatagga accactccga gttttttccc 3482161 tgagatgact ttcgatttcg cagcctgaac cggtgtattg atatccactt cttccagagg 3482221 aagatcgcgg gtaatttcaa atgccatgag tgtagccact tcatctacta actctctaaa 3482281 atccttcgta cctgtatttt cattccgtat atatgtcagc ttgtgctgaa ttaaaggatg 3482341 atcaaataca taaacctttc ccatactgtg tttcagctcc ttttttattg tcccatcaac 3482401 aattacacac ttctattgat tctacaaaaa aagacattga gtttcaagaa catcgtcaaa 3482461 aaacccgccg ggcataagcc caagcgggtt ttaggatctt aataatctaa ttctttatat 3482521 aaaggaaatt tatcagtcag agcagctaca cgctgtcttg cttcttcaag ttttccttca 3482581 tcttcgtggt ttttcaatgc aagcgcaatg atagcaccga cttcttctaa tgcgtctccg 3482641 tcaaaaccgc ggctggttac agcagctgta ccaagacgga tgccgcttgt tacgaaaggt 3482701 ttttcaggat catatggaat cgcgtttttg ttagacgtaa taccaatttc atcaagtaca 3482761 tgctccgcaa ccttaccagt cagtccgagc gaacgaaggt caacaaggat aaggtggttg 3482821 tctgttccgc ctgaaacgag ctggatgccc tctttcgtta aggcttcagc cagacgtttc 3482881 gcgtttgaaa tgacgttttg tgcatatgtt ttgaaatcgt cctgcaatac ttcaccgaat 3482941 gaaacagctt ttgcggcaat aacgtgcatc agagggccgc cttgaattcc agggaagatc 3483001 gatttatcaa ttttcttgcc aaactcttca cggcaaagga tcataccgcc gcgaggaccg 3483061 cgaagtgttt tatgtgttgt tgttgtaacg aaatcagcgt aaggaaccgg gtttggatga 3483121 aggcctgccg caacaagtcc tgcgatatgt gccatatcca ccatgaagta agcgccgact 3483181 tcatcagcaa tttcacggaa tttcttaaag tcgattgtac gaggatacgc acttgctcct 3483241 gctacgataa gcttcggttt atgagcgagg gctttttcac gcacgtcatc gtaatcaata 3483301 tattgagttt ctttatctac gccgtactca acaaagttat attgaacacc gctgaagttg 3483361 actgggcttc cgtgtgttaa atggccgccg tgggagaggt tcatcccaag tacagtatcg 3483421 ccttgctcca aaatcgtgaa gtacactgcc atgtttgctt gtgcgcctga atgaggctga 3483481 acgtttacat gctccgctcc aaagatttcc ttcgcgcggt cacgggcgat atcttcaacg 3483541 acatcgacgt gctcgcatcc gccgtagtag cgtttgcccg gatatccttc tgcgtactta 3483601 tttgtcaaaa cagatccttg tgcttccata accgcttcac ttacaaagtt ctcagaagca 3483661 atcaattcga tcttagtctg ttggcgttca cgctcatttt taatggcgtt aaacacttgt 3483721 tcgtcttgcg caggtaaatg tttcatcagc gagatcctct cctatccgta tcctgttctt 3483781 tgtttttacc atcactattg tacatggttt ttaaggccga tgtaaaagat tatttttaaa 3483841 aaatctaaat ttttattggt aaaaacgaat attaataact taaatttaat ttaaagttcg 3483901 gaatttattt cactatctta aaataaaaga aaagactggc tatgcagtcc tttcattcgc 3483961 actcataaac cgcccgcact ccgccgatta gtttcggccg tgtacgcgcc aatgtcacat 3484021 gagctgaacc gaggctgttt tgagagacac gcacagggac agccaccggt ttcagatgca 3484081 tgccgataaa cgtatcgcct atatcaattc cggcgtcagc ctgaatggtt tcaacaagaa 3484141 caggagactt catctgctta aacgcataag acgccatcgc tccgcccgct tttggaacgg 3484201 gcacggcaga aacggttgga agcctgaaca gcttggctgt ttctgcttcg acgacaagcg 3484261 ctctgtttaa atgctcgcag cattgaaacg ccagatggat tcccgttttt tcccggagct 3484321 cagcaagtcc gctgtagatg ctttcagcga tatctacact gcccgatgtg ccgatccggc 3484381 tgccggccac ttcgctcgtg ctgcatccaa ggacgaagag ctgatcttgt ttcaattccg 3484441 cttggtcctg aaactcagac agcatcgtct tccacgtttg tttcaactca ttcattaaac 3484501 agcaccccta caggtttttc tcttcataat cggagatttt tccaatacgc gtttggtgtc 3484561 ttcccccggt aaactcagta gtcagccaga tttttgcgat ttcccgagcc aaaccaggtc 3484621 cgatcacccg ttcacccatc gcaaggatgt ttgtgtcatt atgctccctc gtcgccttcg 3484681 cgctgaaggt atcgtgcgcc agcgcgcagc gaatcccttt tactttatta gcggaaatgc 3484741 tcatgccgat gcctgtcccg caaattaaaa tgcctctgtc aacttcgccg ctaaccactt 3484801 tttcggccac cggaaaagca taatccggat aatcgacaga gccgctgccg cagtcacagc 3484861 ccatatcaat atattcaatt tgcaattcgt ccattaactc tttgatttca tttcgaatgt 3484921 gaacgccgcc atgatccgat gcaatggcta ctttcatctg cttttcctcc cagcgtgtgt 3484981 gatgcggccc gcccgcttta ttgaccgcgc agcctgtccg ctctttgatt cacaccatat 3485041 gatgtgcttt tcactatatt ctactccttc acgcaggatt tgcaaatgac ctgtttgcag 3485101 attttctgac aacttatcta cggtcttttt tcagctgttt tgccagctgc cgaagaagct 3485161 cttcaagctc atctcgcgtt tgtttataga tgtcaattga gccgccgaac ggatcgagga 3485221 catcaccatg gctgcctgtg acatattctt ttaacgtaaa cactttatca cgataacgtc 3485281 caaattggct ggcaatgatc tgtttgtgct gatgggtcat agccagaacc aaatcagccg 3485341 attccataag ttcttcagtt aatggagaag acacatgatt aagggcaatg tgtttttcaa 3485401 acagcgcttc gactgcatga ggcgtcgctt tcccattagg tgaagcaaac acgcctgccg 3485461 agcggacatt gacattcagc ccttcccttt ctgcaattga tttaaaaagc gcctcagcca 3485521 ttgggctgcg gcacgtattt ccagtacaga caaaaataat atccatgtca gtcacccctt 3485581 atttttctct attatatatg aagaaaaaag aaacggcgac ttcgtttctt ttattggtat 3485641 attaaattgg caaaagcagc tttaatccaa acacgattaa tatgatgccc ccgagcgctt 3485701 cgctgtatgt gccaagccat gactgcactt gttttccgac cagcaggccc agccatgtca 3485761 acatcatgct gaacagcccg aacagggtaa ttgtgaggag cggatgcgag ccgtatatcc 3485821 ccaagctcaa gccgacggaa aagctgtcaa ggctgacgcc gatggcaaac agcaataagc 3485881 ccggccctgc cggtgacatg aatcgttctt ctgactgttt aaaagaggcc ataagcattt 3485941 gaaccccaag aacaaaaagc agcgccccac cgatataaac cgctaacacg ccgaggagcc 3486001 ctgacagcat gttaccggcc gccatccctg cgagaggcat gatgacgtga aagaggccga 3486061 tgatgaaacc aatatagaat atctgcttct ttctaagttt gaccatgccc attccaaggc 3486121 cgacagaaaa agcatccatc cctaaagcaa acgccatgat gcttaatgta atcagttcgc 3486181 ctataaacaa atccgacata cataaataac ccccttggac acgccccgct tttttagcct 3486241 atgcgtgtcc aaaaagggtt agaacatctg actgctttca gcgaatcact cttcctccgg 3486301 cggctttcat cagcctgttc ataatagcaa gaccgacacc tgtatccgga aaggattccg 3486361 ctataatgaa atccacctta ttctcatcaa agctgcgcaa agcatcatac agccctgccg 3486421 caacagtctc aagctgagcc cgtcttccgc agctcttcac ataatcagcg gaataaacgc 3486481 ccgctttttc ttctgtcgtc aggacaccga cccgtcttcc accctgttga tattcttgaa 3486541 tgaggtgctg aatgcgctct gggctgcctt cgcaaatggc aagaggcgct gtcggcgcat 3486601 aatgtgtata tttcatccct ggagaaatcg gcttctcgtt ttggtcgctg agccctttat 3486661 ccacatggat cggcccgatc accgcttcaa tttgttcctt cgtaatgccg ccaggacgca 3486721 agagaacagg gatgtcgtcc gcacatgaaa gcacagttga ttcgaccccg attccggtag 3486781 ggcctccatc cacaataccg gctatgcggc catccaagtc gtgagccaca tgctccgctt 3486841 ttgtgggact tggcttgcct gatagattgg cgctcggtgc tgcaatcggc agtcccgatt 3486901 cgcgaatcaa tgcaagggca agcggatgat ccggcattct aatggcaacc gtttcaagac 3486961 ctgccgttac acgaggtgaa agcgcatcag gtttgcaagg cagaatgagc gtaagtgctc 3487021 ccggccaaaa ccgtttcatc aatgttttcg ccttttccgg cgccgggccc gttaaatcct 3487081 caagctggct gatatccgca atgtggacaa tcaggggatt atcgctcggc cgccctttcg 3487141 cctcatatat ttttttgacg gcatccgtat tttttgcgtt tgcgcctagg ccatatactg 3487201 tttctgtcgg aaaggcaacg acctcatttt ctcggagcaa agcggctgct tgtgcaattt 3487261 gtggatcatt tgtggataac tcgtcagtta catccacaaa ccatcttttc gttttcattt 3487321 ctgaccaaac tccttattca caacaataaa acgattgttt tacgcgtgta atccttttga 3487381 aagtataaaa gatgtcctgt aataaaacaa gcgttatcca caaattgtgg acaacgctaa 3487441 taaagaagtg gataagtatg tgtataaact gcacttatcc agacgctttt ttcatcaaaa 3487501 cggctccttc tgtttgccgc gattcacaga agtgatcaga agaaaacagc tcctccggta 3487561 cactctcagc tctttcaaaa cccatggccg tcagaaagtc cgcagaggaa tgctgatttg 3487621 ctactaggta cacggttttg atctgatgct tttcgcacag cacctccatg ctttgaaaaa 3487681 gcgtgacgat gtggccttgg tgaagcttgt ccgatatgac aagtgatcgc agcagcccct 3487741 ggtcacagct tattttttca ataccgaggc atccggcaat gtttttctca ctgtcctcca 3487801 gcataagaaa ttgagtgaag ccttctttca cgccttcata gctggttttt gcctgtttta 3487861 aaaatgcctc gagcacatct ccgtcttttt cccttgccac ccgcagttga taaaacatcc 3487921 gttcaccccg tttttgcgtt ctttcttcca atctatgagg caaatctatt tttagaccag 3487981 atgattagga aaaaaggtcg gaaatccatt cgactaaaaa gaatttcact tctgtgccgt 3488041 cttctttttc ttcgttctct tcttttttgg ctttttccgc tttagcggtt acgtcctcaa 3488101 gcactttttc agtctgcttt tttgaggctt ctttatcttc ttgttctttg acggcttccc 3488161 cgttagaaaa atcaagaaag cagaggggcg ggaacagcac acaccaccag ttggcgccgt 3488221 ctccgtttcc aagcgtaatc aaaatcgctt catactcacc agcgggatat accatgttgc 3488281 cgtaaagctt tgtcggaaac gagattttgt caaaatcaac ggatatcgac tgattcgctc 3488341 cttctttctc cattgtttcc tttgcaattg ctttgatttc aggcagcttt gaacgaatca 3488401 cgcgacgcgc ttcttcaata gaagtaatat cctttaccca agttgtgatt tctttattca 3488461 ccgcgtctct tatatgacgt tttaattgct ggtcttgatc actatcgctg tttgccagta 3488521 ttctcaaacg aatcgcctga tcaggtatga ccaccggctg attttccgat ttttgtgccg 3488581 tctcttcttt tgccagccct acgagcgctc cggataataa aagaaagata tatatacaaa 3488641 tgattactgt ttttttcatc ggtccccacc gttcctctcc gtgctttgtt tctagcccta 3488701 ttatggacaa ggagagcctg ggataaacgt gcagggtgaa aaaaatctag caagctgtta 3488761 atcttattta tggtacgata gtgttttagg aggtttaaga tgaaatacaa ttatacagtg 3488821 ctgttatcag cattcacgat gtccgttctt tattcagtaa tttatattca ttcatttatc 3488881 attgccgctc tcatcacaat ggcattttat tttctgtttc cttatttgat cttcgcactg 3488941 ccgcttcaaa tcatgatgaa taaaaagccg aaacgtttca gccctttgta tctgctgtat 3489001 taccttgccg ctgcttttat tgccaacgcg atcattttcg gcatgcttca gccttcggga 3489061 caatctctgt ttcaaaatac agccttttat cttttcgctg tattaacagc tcttatctat 3489121 tggatatggg attctgtttt actgcaaaaa aaggaagcct aagaggcttc cttttttatt 3489181 aaaacaaaat cgtcagtaaa taacatagaa tggaaggtat cgccgcaaca aagaaagcgg 3489241 ccgccatttt catgcgagat gtacggcctt ctttggtttc tgaatggtag tttgcccgct 3489301 gatcgcttcc gcttacagcc aaacccgatg taatgatcgc gagccccact aaaacgagag 3489361 acgcaacgcc aaaaatcgct tcatatgaaa gagcctgcgg aaaaatggtg ccaatcatgc 3489421 tctcaatcgc aatgagcagg attcctgctg tcagggcctt tttcatgttt acatcccctt 3489481 tgctggtgtt aaacagcttg atccattcac tcgccagcaa gctgcttatt tatttttatg 3489541 aatcagagcg catatggttc tgtcttttcc attaatatct ttcagcactt ccacttccgc 3489601 ccccttaaac gccttgagga tcaggtcttt gaccgccgct ccctgtttcc agccgatttc 3489661 aaaaacgaca aatactttat ccttcataac aagcggaatg tcttccataa accgcttata 3489721 aaatttcagc ccgtctccgc catcggtgag tgcgtgcagc ggctcatgaa aacggacaat 3489781 ttccgataaa tcagccattt cttcctctga aatatatggc gggtttgaga caatgatatc 3489841 cgcttttttt cccgccttaa taaaaggctc aagcagatcg ccctgataaa agcgcacatt 3489901 cgctccgagt ttttctgcat tggcagaggc gacttgcagc gcctctttcg aaatatcgac 3489961 cgccgacaca gaaaagcttt ggttttcaag cgcaagcgtg acggctattg cgccgctccc 3490021 tgtaccaacg tcaacaactt cgagcttgcc gtcttcagaa aaaacactcc gatatttttc 3490081 aagcaaatga aagacaactt cttcagtttc cggccgcggg atcagcacat catcattcac 3490141 cataaattcc cgtccataaa aaaactcttt tcctataatg tattgaaccg gcacgccctc 3490201 tttatgcatc tcaacgtgac gcttaaagcg atacagttcg tcttcaccaa tcggttcctg 3490261 taagcttgcg agcagcttgc ttctctccat tccggtatca taaagcaata ggagctcggc 3490321 cgcattttct tctcttcccg cttcggttaa ataagaagaa gcccatttca gggcttcgaa 3490381 tatcgtcttc atcttaacct tccgactgct gaagcttgct tgcctgatct tcaacaatca 3490441 gcgcttcaac cacttcgtca agttttcctt caagaatctg atcaagcttt tgaatcgtca 3490501 aaccgattct gtgatccgtc acacggtttt gcgggaagtt gtatgtgcgg atacgttcag 3490561 agcggtcacc agatccgact gctgatttcc gtgtttgatc atattcagcc tgggcttcct 3490621 gctgaaattt atcatagatt ctggcacgga gaaccttcat tgctttttct ttgttcttaa 3490681 tttgagattt ttcatcctgg catgatacaa caacacctgt cggcaagtga gtcagacgaa 3490741 ccgcagacat tgttgtgtta acgctttgtc cgcccggtcc gcttgaagca aatgtatcga 3490801 cacggatatc cttctcatgg atgtcgacct ctacctcttc tgcctcagga agacatgcca 3490861 ctgttgcagt ggatgtatgg atgcgtccgc ctgattctgt ttccggaaca cgctgtacgc 3490921 ggtgggcgcc gttttcatat ttgagtttag aatacgcgcc gcttcctgta atcataaaga 3490981 tgatctcttt gtagccgccc gttccggtta cattcgcttc catgacctct gttttccagc 3491041 cctgaagctc agcataacgg gaatacattc tgtacagatt gcccgcgaat aaagcggctt 3491101 cctcgcctcc cgcagccccg cggatctcca tgataacgtt tttgtcgtca ttaggatctt 3491161 tcgggatcag gagcaccttc agccgttctg acagtgtttc cgtttccttc tgaagttcag 3491221 aaatctcttc cttcaccatg tcgcgcatct cagcatccag cttctcttca agcatcgctt 3491281 ttgcatcagc cagctgttct gacgcatctc tgtattgtct atatacgtca actgtttctt 3491341 gtatatcaga ttgctctttt gaatattctc ttagcttttt cggatcgttg actacttctg 3491401 gatcgctcaa aagctcattt aatttctcgt atcgttcttc aattgatttt aaacggtcta 3491461 acacggtctt cacctctgtt ttcctgtgcg taacattctc attatagtat agtgattaac 3491521 cccagtcaaa agcatttcaa tcccagctgg aaaagctccc tctgctatac tggaattcga 3491581 ggagggatga tgttgctgaa atccatacat catattgcaa tcatatgttc agattacgaa 3491641 aagtcgaaag ctttctacgt acataagctt ggttttcagg tgattcaaga aacgtaccgc 3491701 gaagagcgcg gctcctataa gcttgatttg tcgcttaacg gctcgtatgt cattgagctg 3491761 ttctcgtttc ccgatccgcc cgaacgacaa acccggcctg aagccgcagg cctgcgccac 3491821 ctcgccttta cagtcggcag cttggataaa gctgttcaag agcttcatga aaaaggaatc 3491881 gaaacagagc caatcagaac agatccgctg accggcaagc gtttcacctt cttttttgat 3491941 cctgaccagc ttccattaga actgtatgaa caataacagt ttttgaagaa aaaaaggaga 3492001 tacccacttt ctttgccgaa tcttttcttg ttttgtctaa cgggaaggga accgcattct 3492061 atggtcgaat acctagctta aaaggaggta tgggatcatg aatacaaata tggtagcaag 3492121 tgaactcggc gtctccgcaa agacggtgca gcggtgggtg aagcagctga atcttccggc 3492181 cgaacgcaat gagctcggac actattcgtt cacggcagaa gacgtgaagg ttctaaaatc 3492241 cgttcaaaaa caaatctctg aaggcacggc gattcaggat attcatctgc cgaaaagcgc 3492301 taaaaagcgc acaggcttcc ttgtccaaaa aacaagtagc gacacagaac gaagaatcga 3492361 gcagcttgaa caaaagctgg acaccctttt acagcaaagg caggacgaaa gcgaattgat 3492421 ggcaaggatg tcggaactgg aacgccagct gaaacaaaaa gccgatgaag gtgtatctta 3492481 ccagctgctt cagcaccgca gagaaatcga tgatattctt gcagatctgc aatcactgac 3492541 ctcacaaatg aaagaattca ccgctcattc gatccccgag actgctgctg cttctgaaaa 3492601 aaccaaaaca agaaaaaaac cgctgctgtc actgttcaaa tttcaaacct aaagcaaaaa 3492661 gctcccttaa agggagcttt ttttgttacg cagtaagcgc gataatgatt ggaagtgaaa 3492721 tcaatgacag aatcgcactg accacaaacg cagttgcagt ttcttcttct tgtttctcga 3492781 aacgagtcgc aatcatggct gcaacggcag aaccagggaa tgcaacaaga aggattgctt 3492841 ttgttgtttg gtcagctgga agtccgatag caagagcaat caggaacatt aacgcaggct 3492901 gaaccgcaac ttttagtaac gcaataccga tagccggcat actgagttta attttacgaa 3492961 taccaacggt aacaccaaca gcgaagagag caacaccaga tgttgtgctt ccaagctgat 3493021 caagcatttt aacacccagc tcaggaagag tgaaattgaa aaccagcacc aagatcatac 3493081 tgattaacgg agcagctgca agcggctcac aaagaccatg caggattgat tttcctgtca 3493141 tcttccagaa gctgtcgcca ctctcttcgt ttttcttaga agactcacca acagtagcga 3493201 taatgatcgc gagcggatca agaatcgcgt taaccacgat acctgtgacc gcgatcggaa 3493261 tcgcaacttc attcgctccg aataagcttc ccaataccgg gatacccata aatgcgaatg 3493321 tcggctgtgc agagttcaaa gaaaatacag atgagttcgt taaatcatac ttgaatataa 3493381 atctgcaaac caaaagaatg atgatataga aaccaacaat cccaataatt aaagaaatca 3493441 ttaaaggtac ttgtgataaa aattcacttc tggaagttgt caaaatacca gcgataaagt 3493501 gagctggaag tgcgtatttc gttactaacg tacttacccc ttttgccgac ttggcatcat 3493561 aacttccaaa atgtcctgca aaccaaccca gcacgataac aaagaagatc ggcgccagga 3493621 ggattaagat atctaagatg ctcaaaatat tctcctccaa atcctatgtc cgtatacttt 3493681 agctttacaa aaagctttcc ctcggacaga aaaatttact cgctaattat ttcgcgatga 3493741 cttttttgta ttcaggtgtc cacattgcat caagtaccgc ttgtttcaca tcttcaggct 3493801 gacgatttgc cacgccgtct ttaattgctg cttcagcaac ggcaatcgca acttggatag 3493861 aaacctcttg aagcttatca atgcttggaa gcaatcctgc tccaggtgtt tcaagatcaa 3493921 ccatttcagc aatcgcatca gcagttgcag caaacatagc aggtgtaatg atacgcgctt 3493981 cagctacaat tgaaccaagt ccaagaccag ggaacgcgaa tgcgttgtta gattgtccga 3494041 tttcataaga aacaccgttg tattctacat tgtcaaatgg gcttcctgtt gcaataagca 3494101 cttttccgtc agtccatttg aacagatctt caggaacagc ttcagcaagg tgagtcgggt 3494161 tagacatcgg catgataacc ggacggtcta cgtgagatgc catttctttt acaatttcct 3494221 ctgtgaatgc acctgaaacc cctgaagtac caatcaagat tgttggtttc gcttgacgaa 3494281 caacttcatc gaatggaatt tgaccttttt catcgcgctt ccagtctttc acttcatccg 3494341 cattgcgaag gtaaggtttt tggaaatcaa ggatgccttc gatgtcttca gtcagcaagc 3494401 ctctgtaatc aagtgtgtag aaacgtttgt tagcttcttc ttcagataat ccggctagca 3494461 ccattgtgtc acggatttgg tcagcaatac cgataccagc agaaccagca ccgaagataa 3494521 caacacgctg atctttaata gaagcgccgg ttttcttcat agcggcaagc acacctgcaa 3494581 gtgtaatcgc gccagtacct tgaatatcat cattaaatgt caggatttca tgattgtatt 3494641 ttttcatgat gttgcgtgca tttttgttgc caaggtcttc ccagtgaaga agcgctttag 3494701 ggaagaattt caatgcagct tttacataag cgtcaatgaa agcttcgtag cgttcacctt 3494761 gaacacgttc atgcttgtta ccaatatata aaggatcgtt tagaagtttt tcgttgttcg 3494821 taccgacatc aagcacaacc gggataacac ggctagggtc aataccagct gcagcagtgt 3494881 agacagccaa tttaccgatt gcaatattaa taccgcctac accccagtca ccgataccga 3494941 gaatgctttc ggagtcagta gcaacgataa gatcaatatc gcctgctgtc gcatgaaggt 3495001 tttcaaacgc tttttcaata ccgtcaatgt tatcgattga caagtagatt ccttgaggtc 3495061 ttctatattc atggctgtat tcctgaatcg cttcaccaac tgttggcgtg tacacaacag 3495121 gaagcatttc gcgaagatgg tttttcagca atttatagaa aagaacttcg ttacggtttg 3495181 caagatcact taagtaaaca ttttgacgaa ggcggtcagg ctgcgcttgg aattgctcgt 3495241 acgcgcgttg tgcttgttga tcaagagaaa gtacagttgg cggcagaagc ccttctaagc 3495301 cgagttcttg tctttcttct agtgaaaaag caacgccttt atttaaagta ggaatagata 3495361 aaacttcttt tcctctaaga gttgtttcta agtggccttc tttcgttttt tttatgttat 3495421 tcaagcaaat ctccttcttt cttgaaatag ttaaccaagt taagtaataa cccatctaaa 3495481 atatgaccga tcatgatctt tatgcgactt tgtgacaatt attcgaacaa tgtctcaaaa 3495541 ctatttacat tacgtaagct attgtatgcc tgtcaaaatc aaaattcaag agaagaaaat 3495601 tacttaattt tttaatatac ttatttaaat tttttaattg aatattatca gaatataaaa 3495661 aaaacaccgg tgtttttagc cggtgcattc tatctttata cccatgtttt ggactatttt 3495721 ttagatttac ctgggacttc gtgatgatgt ctgcatcttg cttcatatga ttcagctgca 3495781 ccaaccaaaa tgaccggatc atcgtaagaa gcaggtttgc cgtcaatgag gcgctgtgtt 3495841 ctgctcgccg gtgatccgca aacagaacag acggcttgca gctttgtcac actttccgca 3495901 atcgccatga tattcgggac gacaccgaac ggctctcccc taaaatccat atcaaggcct 3495961 gctgctatca cacggtagcc tttatcggca agagatgata aaacctcaac aatttcctga 3496021 tcaaaaaact gcacttcatc aaccgcaacc acatctgtac tttcactgat gtgatcccaa 3496081 atgtccgcag cagacgaaat ggcatagctc gtcatcgatg ttccattatg ggagacaaca 3496141 gcagcttcgc tgtatcggtt atcaattaca ggcttaaata ccctgacttc ctgcttggca 3496201 taagttgctc tcttcactct tctgatcagc tcttcagatt tccccgagaa catgctgccg 3496261 caaatcagct caagccaccc gctttgtttc attatgtaca taggcttcgc tcccctctct 3496321 ctgccagctg tgttttagac aatataaaaa acaggcaaga ctgctgcttg cctgttgaga 3496381 aatctattat tacttaagac cgtatttttt gttaaagcga tcaacacgac catcagcaga 3496441 agcgaatttt tgacggccag tgtagaatgg gtggcattca gagcaaatct caacgcgtac 3496501 ctcttctttt actgagcctg tttcaaattc atttccgcaa gcgcatttaa ctgttgcttt 3496561 tttgaaatta ggatgaattc ctgctttcat tgtatccatc tccttccgcc ctgaatcccg 3496621 tgtggaaaca gagttattat ttcggagcat tgtccgaaac gcatatgaga aaattatatc 3496681 agtgatttac ttcttttgca aatacaattt accttcttgc agatgataga tttgcctgtt 3496741 tccattcttg attgagaata tcgaaaaatt cctggtttgt tttggttttt ttcatttttc 3496801 tcatgaactt ttctgcgaaa tcaggtgaat cagacatcgt tttgcggata gaccataaac 3496861 gatcaagatg ctctttaggc acaagcagct cttctttgcg cgttcctgaa cggcggatat 3496921 cgatggcagg gaagatgcgg cgctcggcaa gagagcggtc aagatggagc tccatgttgc 3496981 ctgttccctt gaattcttca taaatgacat catccatacg tgaacctgta tcgaccagag 3497041 ccgtagcaag gatggttaag ctgccgccct cttcgatatt tctcgcagcc ccaaagaagc 3497101 gtttcggacg gtggaacgcc gctgggtcaa tccccccgga aagcgttctt ccacttggcg 3497161 gaatcactaa gttgtaggcg cgggcaagac gtgtgatgct gtccatcagg ataatgacgt 3497221 cttttttgtg ttccacgaga cgcatcgcac gttcaagcac aagctcggcc actttgatat 3497281 ggttttccgg cacttcatca aacgttgagc tgacgacatc cccagctaca gagcgctcga 3497341 tatcggttac ttcctcaggt ctttcgtcaa ttaaaagcac gatcagctct gcttcaggct 3497401 ggttcgctgt aatgctgttg gcaatttcct tcagcaacat cgtttttccg gctttcggcg 3497461 gcgcaacaat caatccgcgc tgcccaaatc caaccggcgc catcatgtcc ataattcttg 3497521 tagacaagaa gttcggcttt gtttcaagca ccatttgacg atccggataa agtggcgtaa 3497581 gagccgggaa atgcacacgc tcttttgcag attcgggatc atccccattt actgcttcaa 3497641 cgtgcaaaag tccatagtaa cgctcatttt cttttggcgg gcgaaccttg ccagatactt 3497701 tgtctccgtt ccgcaaatcg aaacggcgga tttgtgaagc tgagatgtaa atgtcttctg 3497761 agcttggaga gtagttgatc ggtctcagga atccgaaacc ttcagactgg atgatctcga 3497821 gaacgccttc cataaacagc agatcttcct gttctgcatt cgctttcaga atggcgaaaa 3497881 tgagttcttt ttttgtcagt ttgctgtaat aggagatttt ataatgtctt gcaagttcat 3497941 aaagctcttt caatttcata ttttccaaag aggaaataga tacgtctttc ataaaaacac 3498001 cacgcttttc atagtcaata tcttactctg aacatgtcat ctgctgcttt tgcacaacat 3498061 ccgccaaagc acattctttt tttaacataa aggaacttct atcggtaaca cttccaccca 3498121 tgatcggcgc ttttgttaaa aggattgtct taatgagttt tgaaggaagc gaggacaaaa 3498181 acatgagaag atcaatactt atatcgtctg tatgcggtag aaattgaaac tttcctagtg 3498241 cttaaaagaa ggtattacgc agtaaaattc gcagcactct ttatttttac cttatttcaa 3498301 aaaattattc aactgaaata aggttttgac acggaattga tagagttgac gcttttctgc 3498361 aaaagttaaa gcgggctcac acccgctttt tctgtttgtt atggacggat tacaagattt 3498421 ggtttctttt tcaagctgtg tctgccgtca acgaaacgaa cagtgcccga ttttgcacgg 3498481 ataactaagc tttcagttgt accgacagag cctttgaatt gaactccttt taacagctcg 3498541 ccgtcagtaa cccctgtagc tgcaaaaatc gcgtcatcac ccttcacaag gtcttccatg 3498601 cgaagcactt tgcttaaatc aaggcccatt ttgtgacagc gagtgatttc ttcttcgctt 3498661 tgcggaagaa gtttaccaat gatttctccg ccgagtgctt ttagcgcaac agcggaaagc 3498721 acaccctcag gagcgccgcc tgatccgaac aggatatcaa cgcccgtgtg gtcgaaagcc 3498781 gtgttgatgg cgcctgcgac atcgccgtca ttgatcaatt tgattctggc gccggcctca 3498841 cgaagctcgg aaatgatttt tgcgtgtctt tcacggttta aaattgtggc aacgacgtcc 3498901 tcaacgtcct tgtttttcgc ttttgccacc gctttaaggt tgtcaatgac aggtgcttcg 3498961 atgtcaatgc agcccaccgc ttccggaccg actgcgattt tttgcatata catgtcagga 3499021 gcattcagaa gcgtgccatg gtctgcgacc gcgataaccg tcagcgcgtt ccagccgccg 3499081 cttgctaaga tgtttgtgcc ttcaagaggg tcaactgcga catcaacgcg agggccgtac 3499141 ccgtttccga gtttttcccc gatatacagc attggcgctt cgtccatttc cccttcaccg 3499201 attacaacgg tccctttcat cggcactgta tcaaaaacgt ctctcattgc acttgttgcc 3499261 gcttcatcag cctcatcttt ttttccccgg cccatccatc ttgctgatgc caatgccgca 3499321 gcttctgtca cacgtaccaa ttccattgat aaacttcttt ccatttcaac acgatctcct 3499381 ctcacaagaa accattatga attttgaagc tgttctattt cttcgtcagt cattctttca 3499441 cgccaaattg tcgctccaag cccctcaagc ttcttctcaa ggctgctgta tcctcggtca 3499501 atatgctcca gtcccgtaat ttccgtgacg ccatcagcca tcagtccggc taccaccaag 3499561 caggctccgg cacgcagatc actcgccttc acttttgcgc cttgaagctc gacaggacct 3499621 gtgatgatgg cagatctgcc ttctactttc atattggcac ccattcgtct cagctcatca 3499681 atgtgcttga atcttgccga gtagatggtg tctgtgacga cactcgtccc tttcgccctt 3499741 gtcaggagcg ccgtcatcgg ctgctgtaaa tcagtcggaa accccgggta tacgagggtt 3499801 ttgacgtcaa ccggctttaa gttcttctgc ccgccgacaa tgaggagctg gtcgtcgctt 3499861 gtttcgatat gatagcccat ttctctcagc tttgccgtta acgactcaag atgagtaggg 3499921 atgacgttat cgataatgac ttccttgccc attgcagccc ctgcaatcat aaatgtcccg 3499981 gcttcaattc tgtccggaat gatcgtatgc ttgcagccgt gcagttcctt cacgccgtcg 3500041 attcgaatca cattggtgcc cgcacctttg attttggcgc ccatgctggt aagcaatgtc 3500101 gcgacgtcaa tgatctcagg ctccttggca gcgttttcga tgatcgtttt cccttctgcc 3500161 aaaacagcgg cgagcataat gttaatcgtt gccccaacgc ttacgacatc taaataaatc 3500221 cgtgcgcctc tcagcctttc agctcgcaaa taaatggcgc cttgttcatt ggttacttca 3500281 gctccgagtg cttcaaagcc tttgatatgc tgatcaatcg gacggggccc taagtgacag 3500341 ccgccaggca atccaatgac cgcctgcttg aagcggccga gcatcgcccc cattaaataa 3500401 tatgacgcgc gaagcttttt tactttcccg ttaggaagcg gcatgctgat catcgacgta 3500461 gggtcaacaa ccatttcccc attctcaaaa tgcacgttgc cgccgatttc ctttaacagg 3500521 tcacgcagcg tttcaatatc tgaaatctct ggaagccctt caattgtcac ctcggaattt 3500581 gccaaaatgg ttgcaggtat taacgcaaca gcgctgtttt tagcgccgct gatatgtact 3500641 gtaccgttta acgagtcacc gccggcaata ttcaactttt ccatgatagt ctccttccat 3500701 aagaagatag ctgcggagct aaataaaatg tcattttatt ctgtctctgc aaataaagct 3500761 catgtccaaa atctagccaa ttcgaagaga aagaatacaa cacattgtaa aatatcagga 3500821 agaaaatagc gaagctttgg ggggtacagg tttcaaaaga tgcacagaga cccgccggct 3500881 cgagagacat cgtcgtcatc cggcaaaagc agtacgcata cccttcattc cgatatcagc 3500941 ttctgcagcc caatgattcc ttctctgtaa agcggcgtca gcatctgaag atccgctgta 3501001 tcaggtcggt gaaatacaaa ggccgcggca aacaggcata aagctgtttg ccgccccttt 3501061 cattatttgt tccagtctgc caggaattgt tcgattcctt tgtctgttaa cgggtgttta 3501121 gtgagcgcat gaatgacttt cagcggcatt gtgccgatat gagcccctct aagagcagct 3501181 tctgtcacgt gctgcggatg gcggattgac gctgcaatga tttgcgtgtc aaggccgtga 3501241 atgtcaaaaa tctgtttaac ttctgaaatc aggtcaagcc cgttgtggcc gatgtcatct 3501301 aaacgtccca ggaatggaga tacatatgtt gcccccgctc tggcagcaag aagcgcctgg 3501361 ttggcattga agatcaatgt aacgtttgtt ttgatgccta agtcagtaag tgctcttacc 3501421 gcttttaaac cgtcagacgt cattgggatt ttcaccgtaa tgttcggagc gatcttcgcc 3501481 agttcttttc cttcctcgat catttcctca gctttcaaag aaataacctc tgcgcttaca 3501541 gaccctttca cgacgtctgt gatctcgcga agacggtcgt ggaatgatac gttagcttcc 3501601 tttgctacta aactaggatt cgtcgttaca ccggcgagaa ttcctaattc attcgcttct 3501661 ctaatttcat cgatattggc tgtatcaaca aagaataaca ttttcaaaaa gcctccctga 3501721 ttaagaaatt ttctgaactg cgaatatgat tgcgctttct aaagatagac ggaaaaccgc 3501781 ctgtcaagct gtcaggcggc tataaaaagt tccaattgaa ttaagcttgg tttgaagaac 3501841 caaattcacg cattttaccg ataactgttt ctttgatcgc ttcacgagct ggtccaaggt 3501901 atttacgtgg atcgtactcg tcaggcttag ctgccaatgt ttcgcgaaca gcttttgcag 3501961 aagaaatttg gttttcagta ttcacgttga ttttagctgt accaagtgaa attgattttt 3502021 tgatgtcagc agtcggaatt ccagtaccgc cgtgaagaac tagcggaagg ccagttgatt 3502081 ttccgatctc ttccatttct ttgaagccaa ggtttggctc acctttgtaa gggccgtgaa 3502141 cagaacctaa tgcaggtgca aggcagtcga tgccagtgcg ctcaacaagc tcttggcact 3502201 ctttaggatc agcgtagatt acgccttcag cgataacgtc atcttcttgt ccgcctactg 3502261 ttccaagctc agcttctaca gatactccgt ggaaatgagc aagctcaaca actttagcag 3502321 ttgttgctac gttttcttca aatggatggt gagaagcgtc gatcattaca gatgtgaaac 3502381 ctgcatgaat cgctttcgca caagattcaa agcttgaacc gtggtctaag tgaatcgcaa 3502441 caggaactgt cactttgtac tcttccataa gtgcttttac catagcaacg actgttttga 3502501 agccgcccat gtagcgtccc gcaccttcgg aaacaccaag gatcactgga gatttttctt 3502561 cttcagctgc ttgtaaaatc gcttgagtaa actcaaggtt gtttaagtta aattgtccta 3502621 cagcgtaccc tttttcttta gctgtattca acatttccgt catagaaact aaaggcatgt 3502681 cgaatgtcct ccttatgtag cctgattgtc ttctagcgaa aaaagctttc caccctagca 3502741 tgacccatat attgctgtca tatgtaaata ctcagatcgc tttttctcca taactaggat 3502801 accaactttt cgacaaatcg gcaacataat gacatgattc atttgtttct tctttttgtc 3502861 agttagactt caggggcaga tattttttga cggcgtctct gatttcgtcg atgtcaaacg 3502921 gcttggcaaa gtgcgtcaga gcgcccaatt ccttcgattc ctggatcatg tcgagctctc 3502981 cgtatgccgt catgataatg acccggatgt tttcgtcaat gaccttcatc cgttttaaga 3503041 tttcgattcc gtccatgccg ggaattttca tgtccaacag cacaaggtcg ggccgttctt 3503101 ttgtcacaat gtcaagcgcc tgcaggccgt tcgcagcctg aaacgtctgg tagccttctt 3503161 tattgaacac ttcatttagc aaaatacgaa tgccgtattg atcatcaacg attaaaattt 3503221 tttcattcat cattttacac cccaatatta tgattttcgt caaaagtaag cagtattgta 3503281 tgtattctgt ttgattttcc tatttccttt aattataata gtctacttta cgacattttc 3503341 tgagcatttt ctcttttgtt gtatactgat attgtacgtt ataaaggagg attcacttat 3503401 gttgaaaata ttcacgacgc agttaacagg tattttttcc cgcattcagg ataaggaatc 3503461 tgacgcgatt gaagatgggg cgcggctgct tgctcaagcg gtgatcagcg ggcattccat 3503521 ttatttatac ggagcgaatg agcttcaggg cgtcttttat gaggccaccg aaagcaaaga 3503581 acccttccca tctgtcaaag cctttccaga aaacgctgag gaagtgacag aaagcgacag 3503641 ggtgctgatg ttttgctcag ggacgggcac agccgaagaa caggagctcg caaaagagct 3503701 ttatgaaaaa ggtgcgggag tcgtatgcgt atcgcccgca gccaaagaca gtgcgggaat 3503761 agaacagtat tgtgatgtgc atattgattc taaattaaaa atgccgcttg ttcccgatga 3503821 agacggcacc cgttacgggt ttccctcttt aatgacagca ctgtatgtct atcacgcttt 3503881 atcgtttaca ctaaaagaaa ttctgcaaga gtatgcataa tatcttattg tacatgctgg 3503941 aacttgccgg aaacaaataa aaaagacttg cccgcttttg acaaacggca agtctttttt 3504001 attacttctg atttgcagct tcgacagacg ctccgataaa gcctttgaat agaggctgag 3504061 gtcttgtcgg tcttgacttg aactctgggt ggaactgaga agccacgaac caagggtggt 3504121 ctttcagctc gatgatttca acaaggcgtc catcagggct tgtgcctgag aatacgaagc 3504181 cttgctcttc catttgctgt ctgaattcat tgttaaactc atagcggtgg cggtggcgct 3504241 cgtacaccac ttcatcctga tacacttcaa aggctttcgt gccttcttca agcttacaag 3504301 ggtaaaggcc gagacgaagc gttcccccaa gatcctcaac atccttttgt tcaggaagaa 3504361 gatcaatgat cgggtattga gttgacggat caatttccgc tgagtgagcg ccttttaagc 3504421 ccaatacgtt tcgtgcgtat tcaatagacg ccacctgcat gcccaagcaa atgcccaaga 3504481 acggaatgtt gttttcgcgc gcgtattttg tcgcgacgat tttcccttca acaccgcggt 3504541 ctccgaatcc gcccggcaca atgatgccgt ctgttccgct tgtgagttct gcgatattgt 3504601 tttctgtcac ttcttccgcg ttgatccact tcacttttac atctgtgtca aacgcatagc 3504661 ccgcatggcg gagagactcg acaacagaaa tgtatgcgtc aggaagctca acgtatttgc 3504721 cgacaaggcc gattgtaatc gtttgagaca ggttgctgac tttgttaaca agctctttcc 3504781 actcggacat ttccgcttct ttgcatgcca atttcatgtg ctcgcaaaca agcttatcaa 3504841 gcccttgttt ttgaagctcc agcggaatgg agtaaaggtt gtccgcatct tcacattcaa 3504901 taaccgcttt tgtatcgatg tcgcagaaaa gcgcgatttt atctttcata tcttgagaaa 3504961 tcggcatttc tgtacgaacg acgatgatgt ttggctgaat gcccaagctg cgcaattctt 3505021 ttacgctgtg ctgtgtcggt tttgttttta attcgccagc agctttaatg taaggcacga 3505081 gcgtacagtg gatgtacatt acgttttcac ggccgatgtc gctcttcatt tggcggatcg 3505141 cttcaaggaa tggcagtgat tcgatgtctc cgacagtacc gccgatttct gtaatgacaa 3505201 catctgcgtt tgtctctttc cctgcgcggt aaacacggtc tttcaattcg tttgtgatgt 3505261 gcggaatgac ctgtacggtt cctccaaggt aatctccgcg gcgttctttt ttaagaactg 3505321 ttgaatagat tttacctgtt gtcacgttgc tgaatttatt caggttaatg tcgataaaac 3505381 gctcatagtg accaaggtcc aagtctgttt cagcgccgtc atccgttacg aatacttcac 3505441 cgtgctggta cgggctcatt gttcccgggt caacgttgat gtatggatcg aatttttgaa 3505501 tcgtcacgtt cagtccgcgg tttttcagca aacgccctaa tgaagctgct acaataccct 3505561 ttccaagtga ggatacaact cccccggtta caaaaatata tttcgtcatt tcgtttgctc 3505621 ctctcttcgc tcttagctac atttttaaaa tgtactattt tataaaaaat catttagcct 3505681 tttaaatgat ttataagaaa aatgaggggt gaaaataaga aagctccctt tcaatttctt 3505741 gaaagggagc ataacgtact atgttctctc ttcgtttttg aagagcccaa aatacatact 3505801 acatagttcg actatgaaag tcaagatcgt tttgaagatg aaatctgata ctatttaatt 3505861 tcctcttctt catcatcata gtcttcatca tcttcatcaa taatatcttc ttcgatctca 3505921 agatcatcgt cgtcttcatc aagatcttct tcgtcaaaat cgtcggcttc aagatcgagt 3505981 tcttcctcaa cttcatccaa atcaaggtcg tcttcgtcga tctcttcaaa ctcgtcaaga 3506041 tcaagatctt cttcgactgc tttcttcgct tttttctttt tcgccttgac tgtcggctga 3506101 gtttcttcat caagctgatc ataaggatac cagctgcgaa gcccccacgt ctggtcagaa 3506161 agcgccagga agcggccgtc aatgtttaaa tctgtataaa attgagcaat gcggtctcca 3506221 agctcttctt ttttcacgcc gagcaaagat gcgatttcat ttaaaagctc ctgaaaagga 3506281 actggttttt tatgttcttc aaataattcg tgagcgattt caactaaagc catttccttt 3506341 agctcttcct gtgaatattg tttgataccc aaggtcggac actccctttc tattacttat 3506401 atgtatctgt tttatcaata atgaaagcga ttttgtatcg ttcttataca aaccatacct 3506461 ctcattataa acaaaataaa acagaatatg ctacccttaa cagcgttaat ttaaataatt 3506521 ttacaagagt gatccgactg agagatgttt tccgttaatc cgcgagcatt ctggagatga 3506581 ccagtctttg aatttcttga gtgccttcat agatttgcgt gatttttgca tcacgcatat 3506641 agcgttctac cggataatct tttgtatagc cgtagccgcc gaaaatctgc acggcttcgg 3506701 tcgttacctt catcgccgta tccccagcca tcagtttgga catggcggaa gcttttccat 3506761 atggaaggcc cgatgattct aaccatgcag cctgataggt cagtagcctt gaagcttcta 3506821 tcattgtcgc catatccgcg agtttaaaag cgatgccctg ctgctcggcg atcgattttc 3506881 cgaattgctt tcgctctttt gcatattgaa gcgccgcatc aagcgctcct tgggcgatgc 3506941 ctacagcttg tgcagctatg ccgtttctgc ctccgtcaag cgtcttcatc gcgattttga 3507001 agccttctcc ttcttctccg agacgctttg atgcgggcac tacacaatct tcgaacatga 3507061 tttccgttgt cggtgaagaa cggatgccca gcttcttttc tttcttgcct gtaaaaaatc 3507121 cttcaaaatc cttttctact ataaaagcgg taacgccttt tttctttttc tcgggatcgg 3507181 tgacggcaaa aacaatgtaa atatcagcaa cgccgccgtt tgtgataaac actttggaac 3507241 catttaacac atagtcatcg ccgattcgtt cagcagttgt tttcatgctg ccggcgtcag 3507301 agccagaccc tgcttcggtc aaagcgaatg cgccgatttt ctctccgaga gccagctgtg 3507361 ttaagtactc tgtcttctgt tcctctgtcc caaaggcaaa cagcggccag ctgcaaagag 3507421 agatatgggc ggaaagcgtc acaccggtgg aggcgcacac ttttgacagc tcttccaccg 3507481 cgatgacgta ggctaaatag tcacttccaa ttccgccgta atcttcaggc catggaattc 3507541 ccgtcaggcc cagatttgcc atttcccgaa acagctcgcg atcgaagcgt tcttgttcgt 3507601 cccgttcagc cgctgtcggg gccacctcat gcttcgcaaa atcgcgcacc aattttcgta 3507661 tcatctcatg ttcttctgat aatgaaaaat tcattgcttc tcccccattt tcagatcagc 3507721 gcctaaaacg gattgagcca gaagctcgac gacgtcgtac gttttgactt ggtcttcggc 3507781 ttccttcgcc tttgtgccgt ccccaagcat cgtgagacaa tacggacagc cagaactgat 3507841 caccgatggg ttgactgcga gcgcttgctc tgtcctggcg acgttaatcc tgttgcctgt 3507901 ttcttcctcc atccacatta atcccccgcc ggctccgcag cacatgccgg tttcccggct 3507961 tctctccatt tcaacaagct gcacgcccgg aatggctttc aaaatctctc tcggcggatc 3508021 atagacttca ttgtaccggc ccaaatagca cgaatcatgg aaggtaatcg tctcatgaag 3508081 cgggtgctgc ggtcttaatt ttccgttttt cacaagctcg gccagcactt ctgtatgatg 3508141 ataaacctcg ccttcaaatc cgaaatccgg atattcgttt ttaaataaat tgtatgcatg 3508201 gggatcgatc gtaacgattt ttttgacatc atttttttca aattcagaaa tattcttctc 3508261 agccagctct tggaacaaaa attcatttcc gaggcggcgc ggcgtgtctc ctgaattttt 3508321 ttctttattg ccgagaatcg cgaaggacac gcccgcgtga ttgagcagct tggcaaagga 3508381 aattgcgatt ttctggcttc tgttgtcgta agaccccatg gagcctaccc agaaaaggta 3508441 ctcaaattct tttccttctt ttttcatttc ttttacagtc ggaatctcag catccggcgc 3508501 ctcgtcacgc caattttcac gttccttgcg gttgagtccc cacggattcc cttgccgctc 3508561 aatacttgtc attgcgcgct gggcgtcact gtccattttt ccttctgtca gtacgaggta 3508621 gcggcggagg tcgatgattt tatccacgtg ctcattcatg accgggcatt gatcctcaca 3508681 gttccggcaa gtggtgcatg cccaaatttc ttcctctgtg atgacgtcgc cgatcaagct 3508741 tggattgtaa tcaagcgccg ctgcggcttc ctgcgatccg ctgcccgctg acgccgcagc 3508801 cagctgattg cctctcgtat gccgaaacgc tgctgcgggc acccatgggg agcgcgaggt 3508861 gacggcagcg cctttttccg tgagatggtc tctgagacgc aaaatcaagt ccatcggaga 3508921 aagcattttt ccggtgcctg ttgcaggaca catattggta cagcggccgc actcgacaca 3508981 cgcgtataga tcaagcagct gagactgtct gaaatcctca atttttcccg ctccgtagct 3509041 ttctttcgtt tcgtcggtaa aatcaatttt ttcaagtttt ccggcagatt ccattcgatt 3509101 gaaaaagacg tttgccgggc cggcgattaa atgggcatgc tttgactgag gcacgtacac 3509161 taaaaagcta agcaagaata ggagatggat ccaccatgcg atatagaaaa tcaccgccgc 3509221 gcctgttttc ccgacaccgc taagcataaa cgcaatacct gaggcaattg gctcgctcca 3509281 agaaagccca tgctcatgcc aaatcagatt catcccgttc ccaagcagaa cggtcagcat 3509341 taatcctccg ataaaaatga gaacgagtcc ggctttgaaa ccgcgtttca gcctcacgag 3509401 cttttcgata taacgtctgt agaatgccca cccaacagca attaaaatga gaaacgtaac 3509461 aatttcctga aaaaaggtga aggcgggata gaccgggcca agcgacagat tccggccggg 3509521 agccagtcct ttgatgataa agtcaattgc tccgaactga accaatataa atccgtagaa 3509581 aaacatgacg tgaatgattc cgcttttctt gtccttgagc agttttttct gtccgaatac 3509641 attcacccat atggcgtgaa gccgttcctt gaaccgttga tcaaattgtt ctttctggcc 3509701 gagcttgatg taggccagtc tcgttttgac caagtaaaca aacaaataga cagcgtaagc 3509761 ggttacaatc agaaataata atgcatttgc gatgagaaag ccgctcattc caattccccc 3509821 tttttactga taaagaccgc gatcccctac ccccgaatct gtataagatt atctttatga 3509881 taaataatga atgagtgttc agtcaataat taaattcctg ctgttcgggc acactacctt 3509941 tactacggaa aggagtgccg gtatgaaggt atttatcgtg attatgatca ttgtcgttat 3510001 tttctttgcc ttgattctgc ttgatatctt catgggccgt gccggataca gaaaaaaggc 3510061 gtacgagcct gttttttcaa aaaagaagag tgacatcgaa ttgatccact gcggcgctga 3510121 tctcgttgag cggatgatga atgatattcg ccaggccgcc tcttctgttc acatgatgtt 3510181 ttttattatg aaaaatgatg aggtcagcca caatatgtat accttgctga aaacaaaagc 3510241 ccaagctggc gtatccgttt atttgcttct ggattgggcg ggctgccggg caattaaaaa 3510301 aacggcgctt cagacgatga aaaatgccgg cgtccatgtc catgtgatga atcgtccccg 3510361 ttttcctttt ttcttttttc acatgcaaaa acggaatcac cggaagatta cggtgataga 3510421 cggaaaaatc ggttatatcg gcgggtttaa tatcgccgaa gaatatcttg gaaagaaggc 3510481 gaagttcggc aattgggagg attatcatct gcgcatgatc ggagaaggcg tacatgatct 3510541 tcaaacgctt tttgcttctg atctaaaacg aaataccgga atcgaactgg gttcggatgt 3510601 ttggccaaag cttcagcaag ggactatttc tcacaagatc tatgcgaccg acggttattc 3510661 ccttgaaaac atatacttgg ccaacattgc ccaagcgaag aatcgcctta cggtttgcac 3510721 gccttattac attccatcaa aaccgcttca agaggccctt attaacgcaa gaaaaaacgg 3510781 cgtatccgtg agaatcattg taccgatgaa atcagaccat ccgctggtac gagaagcggc 3510841 ttttacgtat tattcggagc tcttggatgc cggctgtctt atttatcgtt attatcaagg 3510901 gttttatcat gtaaaagccc tcatcataga cgaccatctc agcattatcg gaacagccaa 3510961 cttcgataaa cggagcctgt tcttaaatga agaggtgaat gttgaaattg atgacgaagc 3511021 gtttacaagt gaagtctatg ccacaattga ggaggatatg aaaaagtcgg agctgctgac 3511081 gatggaggat ttcagcaagc gcacattcag gcagcgcccg gcggaatggc tcggcagggc 3511141 attatcttat ttcttataaa ggagagttcc tatgattttc agattcgggt tcgtttcaaa 3511201 tgcgatgagc ctttgggatg cgtctcccgc taaaacattg acattcgcgc gttattcaaa 3511261 gctttcaaag actgaaagaa aagaagcgct tctgactgtg acaaaagcca atttgcgcaa 3511321 tacgatgaga acccttcact atatcatcgg ccacggcatt cctttgtacc gtttttccag 3511381 ttcgattgtg ccgctggcta cgcatcccga cgtgatgtgg gattttgtaa caccgtttca 3511441 aaaagagttt cgggagattg gagagcttgt taaaacccat caactgcgaa caagctttca 3511501 tccaaatcaa ttcactctgt ttacgagccc gaaggaatcc gtcacaaaaa atgcggtaac 3511561 agatatggcg tatcactacc gcatgcttga ggccatgggc attgctgatc gctccgttat 3511621 caacattcat attggcggcg cttacggaaa taaagacacc gccactgcac aatttcatca 3511681 aaatataaaa cagctgccgc aggagatcaa agagcggatg acacttgaaa atgatgataa 3511741 aacatataca acggaagaaa cgcttcaggt ctgtgagcag gaggatgttc cgtttgtctt 3511801 tgactttcat catttttacg ccaatccaga cgatcacgcc gacctgaatg tagcactgcc 3511861 ccgcatgatc aaaacgtggg agcggatcgg ccttcagcca aaggttcact tgtcttcccc 3511921 aaaatcggag caagcgatac gcagccacgc cgattatgtt gacgccaact ttttgctgcc 3511981 actgttggaa cgctttaggc aatggggaac taatattgat ttcatgattg aagcaaagca 3512041 gaaagacaag gcgcttctcc gcttgatgga tgaattaagc tccatccgcg gtgtcaaacg 3512101 catcgggggc ggtgcgctgc aatggaagtc ataaatgtgc aaaaataggt ttacgacttg 3512161 tcagctttgg gaacttaggc tatataagac aacaatcgat ggaggagaaa gatcatgaaa 3512221 aatatcaagt ctctgaaagt agccgcacag gcctttactt taagaaattt gattcatctt 3512281 tataaaatgt gccattccgg aagccacgag gtttatattt attcaaagaa aacgatgtgc 3512341 aaaatcaaaa gcttaattga gcttgaaacg ttccgcatgg ctcataatga aaaggaatat 3512401 ctgatcgtag ttgaaggaac aaaagcatca cagctcattg aaaaattcca aaatctcatc 3512461 gagcctgctg agagagaagc gctctaactt acatacaaaa aaggatagac atctgtctat 3512521 cctttttctt atgctcttac ataatggagc tgaaccgctt gtccaaattg ttttgtccct 3512581 tttaaccgca gttttgtttc atttgttagt tcgtgaaaca gcgggatgcc gcttcctaaa 3512641 acgacgggaa taacagtgat gatgaattcg tcgatggcat cttctttcat aaagtcattc 3512701 acaagctctg ccccgccagc tatccagatg tttgagcctt tttcctgttt caaacgggca 3512761 gtgaaggctc tggctccctc attgataaac gtcacatgtt catcttgata actgtcgggc 3512821 gatcctgtaa aaacatagca ggttttatcc tgatacggga aaaccggtgt tagcacttta 3512881 acgtgctcat atgtgctccg ccctaaaatg actgtatcaa cagtctgata aaaatcactg 3512941 tagccgttgt caccttcacc ttcaaattca tccagccaat cgatgcttcc atcttctttt 3513001 gcgatcatcc cgtccaatga aacagcaatg tacagcacag tttttctttc catgttctcc 3513061 tcctatcgat gcaccatttg cccgaattgc gcttgatgca gcctgctgta taggcctccg 3513121 gcttcgatca ggtcttgatg acggccttgt tcttcaatac cgttgtttgt gacgactaca 3513181 attctgtccg cgtctttgat tgttgccagc ctgtgggcga tgacaagcgt cgtgcgcccc 3513241 tcagacaact cttgaagcgc cttttggatc gccgcttccg tctctgtatc aagggctgag 3513301 gtggcttcgt cgagaatcaa gatcgacgga tttttcaaga acatccttgc aattgacaga 3513361 cgctgttttt gcccgccgga aagcttcacg ccgcgttcgc caatcatagt atccaaccca 3513421 tcgggcatgt tatggacgag ctcttccaga tgcgcctgct tcacagcttg ccaaatgtct 3513481 tcttctgatg cgcctagtcg gccgtaggcg atattttctc taagcgtgcc cgagaataag 3513541 aaaacgtcct gctgcacgac gccaatctgc ccgcgcaacg aagaaagcgt catgtctttt 3513601 atactgatgc cgtcaatcgt aatgtcgccc tccgatgctt cataaaaacg cggaagcaga 3513661 ctgcaaagcg ttgatttccc agcacctgac ggaccgacga acgccaccgt ttcccccgct 3513721 tgaatggata ggttgatgtc attgaggaca ttgtgatggt catcatagcc aaacgaaaca 3513781 tgtttatagc ggatattgcc cttcaggccg gaaacatctt tcgaatcagg tgagtcctga 3513841 atatccggct ctgtctccat gagctccata tagcttttga aacccgcgat ccccctcgga 3513901 tacatttcga taatggcatt aattttgtca ataggcctga acagcacatt cgtcaagagt 3513961 acaaacgcca caaattcccc gtacgataag gagccgcgaa tgacaaacca cgtcccgcac 3514021 aaaaggacaa acagcgtgac aaaccgggtc agcatatagc tgattgaacc gtttttcgcc 3514081 atgattttgt aggaagaaag ctttgtgaca cgaaaacgct ggttgttgac ggcgaagcgt 3514141 tctttttcaa atgcttcatt tccgaacgcc tgcacaagcc ggatgccgcc gatgttattt 3514201 tctacacgcg cgctgaagtc tccgatatcc ttgttcagcg tggtaaatgc tttggtcatt 3514261 tttttgttga aataaagcgc tagccaaatg acgatcggca taatgataaa cgttaataaa 3514321 gcaagctgcc agttaataaa cagcatcact ccgaacgccc cgagaatggt catgaccgca 3514381 atgaataagt cttccggtcc gtgatgggcg acttcaccga tatacattaa atcgttcgtg 3514441 agcttcgaca tcagcgttcc cgtcttgttg ttgtcgtaaa atttgaacga gagcttttgc 3514501 aaatggtcaa aaagcgactt tctcatatca gtctcaatat tgataccaag catgtgtccc 3514561 cagtaggtca cgatatactg aagagccgag ctgagcgcgt acaccgcaaa taacccgatt 3514621 gaggtcgcga tgatcagtcc ccagtccctg cccggcagca aggtatcaat aaaataattg 3514681 acgatcaaag gaaaactcag ctccattaaa cctcccgcga tcgctgagaa aaagtcgaga 3514741 aagaacaacg ttttatatgg tttataatat gaaaaaaatt gccgcagcac cctatcttcc 3514801 cccaatgtat aaataactga taatatttct caattatact atacacgggc tgttttgtaa 3514861 gatcagattt cttttttctt acagaacacc tgaaaacagg cgggcaaacg actcttttgt 3514921 ccggtcagcc acacctcttt tataaaagcc gacagggctg agcttttcac tttcctgcat 3514981 atcctcttca aaatgggcct caagggttcg gatcgcttcg gcatccgtga agaacacatt 3515041 cacttcaaag ttgagctgaa agctgcgcat gtccatattc gcggtaccga cggaggcgag 3515101 atcgccatca atgatcatga ctttttgatg catgaagcct ttttggtagg agtacacttc 3515161 aatgccctca aggagcagct ccgggaaata ggacctcgac gcgtattggg tcaaaaagct 3515221 gtcgttcttc tccggcacca taacccttac ctctaccccc tttgtcgccg ctgcttttag 3515281 cgccgtgcga atggattcat tggggacaaa atagggcgtg gcgatccata ttgatttctg 3515341 cgctgaagaa atcatttcat aataaaggtc gctcatgctt tccttcatgt cagggcctgt 3515401 cgcgacaatt tgataaatgc ctcctccttc cacgggaacc ggggtattgt actcctcttg 3515461 atcaattagc acttcattgg agacatattc ccaatccagc ataaagatag cgtggagcgt 3515521 ttgcacaatt tccccctcaa gccgcaggtg tgtatctctc caaaatccga tgtacggatc 3515581 tctgctgata tattccttcc cgacatttaa tccacccaca aaaccggttt tcccatcgat 3515641 gatcacgatt ttccggtgat ttctgaaatt cagcttctgg ttgaaaaacc cgtatttcag 3515701 cggagaaaac gggacgatgt ccacccccgc ttgtttcatt ctcataatat ctcttcttgc 3515761 cagcttcatg cttcctgccg catcgtataa aaacctcacc tcgacaccct ggcgcgcttt 3515821 ctccatcata atatccatca tgccgcgtcc gagcatgtct gatttaaaca tgtagtattc 3515881 aatatgtatg taagattccg cttttctcat tgctttgaaa atgtccggga aggtttcttc 3515941 gccgtttttc agcactttga tgttgctttt cgtattgata ttcatatggg cagccctgat 3516001 ggaatatgta aagaacctct cttgattgtc cttcagccct gtcacttcgg gcgtttcctc 3516061 cttgtcaaac agcttcctga gcttttccct gttgtacatt cgttttgtct taaacagctt 3516121 tccctttaca taaagctgtc ccgaaaacag ataaaacacg tagccgacga ttggaaaaaa 3516181 gacaagaata tggatccata gcagcgtgtg ctgcgaggtg cggttttcaa gaattaatga 3516241 atagatgctg aacaaaataa tgcttatata gcaaagcaat cctccgtaaa actcaagtct 3516301 ggaaaccgga aaaaaccaaa tgacatatgc cccgatgagc atcatatata aaaagaaaaa 3516361 ttccagtctc cttttcagca tcctgattct ctccaatctg attcaattac ctctgtatta 3516421 cctctttttt ctaatcgata aaccttgtaa gtaaaaaacc tctccgccaa aggaggagag 3516481 gtttagagaa aactaactgt cacggaattc atccgcatcg tttctgcaga aataaagcaa 3516541 gactattggc aacgccgagt gacaacatga gcggcaagct gaacccgctc agcactccgg 3516601 caagcgccga aaagaaggcg gcgctgtgac tgcaaatacg gtggatagag taaatttgat 3516661 acccattctg atgagagaaa atatataaaa cgggaaattg atcagaaaga tataaggagt 3516721 tagtcaggct gaatcataat ctggctgttc cgccggttta aaatgagtaa aatccttgat 3516781 gttatttcca tatacaaaca taacaggatt cccggcagcc cagccattac cttggcagaa 3516841 aaaaccccct cttgcaaggg ggattttcac gagcgtttcc gatatacaac gtagctgcgg 3516901 gtcagatact tgagcggcag actgaacaca tgaaccaatc tcgtaaacgg ccacaggata 3516961 aaaacgacgt atcctatcac aatatgaaac ttaaaccata gcgggacact ctccatcaaa 3517021 gaggcgtcag gcctgaacaa aacgatttcc ctgaaccagg gcccgactgt ggtccggtaa 3517081 tcaaatcctt tcgaatcaat gttgagaaac gtggccgcaa cgcctgacag catcatgaac 3517141 agcagcagga ggagcgtaag gatatcggat ggcgagctcg ttttgcggat tcttttgtca 3517201 aacagccttc tgtacgtcag gatgacaagt ccggtacatg ccgcaatgcc cgccggcaag 3517261 ccagcgccaa tcgccatttt gtgatacata tgctctgaaa tgccaaggga agcatacacg 3517321 ccttctggga tcagaatccc catgacatgc ccgccgacaa cgcacagcag tccccagtga 3517381 aaaagtgtgc tgccagccgc aagttttttc ttttctaaca gctcgcttga tttcgccgtc 3517441 cagccaaatt ggtcatgctg atagcggtaa atatggccgc cgataaagat tgtcaataca 3517501 atgtatggca taatacccca gaggatctgc ccgctcatgc ctgaacagcc ccttcaacgc 3517561 tttcacgtac gccaatgttt tcaagcgcgg ccagcagcac gtgcagcagt tcagcgtata 3517621 tactgtcatt tttttcgaga cgggatgcca gctccctcac attggacaga tatttctcaa 3517681 acacgcttct cgctgcttca atttctgcag ccgcagcaaa ttccagcatc agcggcagat 3517741 aatcaggcag ctctttctct gtcggcagga aaccggattg ctcgtatgtg ttttttaaat 3517801 gcagcaattc aatgccgcgt tccctttgct cgcctgagtt aaagtaggtg acatacatat 3517861 ttgttttttt cccgaagtcg aatgtataga catagtgttc aatcagcgct tccggagaat 3517921 agctggctga cgtctcgaaa aagtgcagca gcttctcccg gatttgccgg ttgccgattt 3517981 cttggataag agccttccaa tcgggaagct cggctctcca ctcttcatcc ggataagaga 3518041 gaagacagga aagagcagag aacgtgattt gccggtctgt ggtgttcatc ttgttacacc 3518101 tcatttatca aaagttagaa acaggagccg gggccgcctg aaaatgataa gccgcagctt 3518161 ccttgttcag cgtataaatc tgatacttct tctcgatggc tgctcggaat cacaaagcgg 3518221 tcatcatatt tggcaatcgc aagcagccga tacatatctt caatttgctg ttctgttaag 3518281 ccgacactgg agatcagttc cggatcgatt gatttattcg tctggaccgc tctcatatac 3518341 tggcgcatga cagacatttt ctttaatgtt gaccgaatat gatccgtatc accggctgtt 3518401 aacagctgcg ccaaataatc tatcgggatt ctcatttggt cgatagccgg aaaaatatct 3518461 tccgccgttt gccggctgcc ttttccttca aagagattca taatcgggct gagcggcgga 3518521 atgtaccaca ccattggcag cgtgcggtac tcaggatgaa gcggcagcgc gatcttccag 3518581 tcaatgatca ttttatagat cggtgattgc tgcgcggcct ctatccattc agccggaatg 3518641 ccttgttctt ttgccagttt ggcaacctca ggatcattcg gatcaagaaa aacgtccaat 3518701 tgggaatggt agagatcctt ttcattttca acagatgccg cttcctccac tttgtccgcg 3518761 tcatatagca tgacgccgag gtagcggatt ctgccaacac acgtctcaga gcagatggtt 3518821 ggcagtcccg cctccaaacg cggaaagcag agtgtgcatt tttccgcttt gttcgtttgc 3518881 cagttaaaat agactttttt ataaggacag gatgagacgc aatatctcca tgaacggcat 3518941 gcgttttgat ccacaagcac aatgccgtcc tcctcgcgtt tgtacatggc gccggatgga 3519001 caggatgaga cgcatgccgg gttgatgcag tgctcgcaaa tacggggcaa atacatcata 3519061 aagacgtcat cgaattctgt tttgatcgat tcctccatct tttgtacgtt gggatcttca 3519121 agtcccgtaa tgtggccgcc tgcgagatcg tcctcccagt tcggtcccca ttcgatattc 3519181 atgaaatccc ccgtcaagga cgatttcggg cgtgctaccg gctggtgttt tttctgcggg 3519241 ctgttcgtta atgtttcata atcatagttc caaggttcat agtaatcatc aattgacggc 3519301 tgattcggat tatagaaaag gcctgcaagc cgattggttt tcgagcccga tttcagctcg 3519361 agctttcctt ttttcaatgt ccagccgcct ttatatttgt cctggtcctc ccattgcttc 3519421 gggtagccga tgcccggctt tgtttctaca ttattgaagt acatatattc cgcaccggaa 3519481 cggtttgtcc acgtgttttt gcaggtgacg ctgcacgtgt ggcagccgat gcatttatcc 3519541 aagttcatga ccataccgat ttgcgcttta atcttcaagc caatcgacct ccttcagctt 3519601 gcggatgacg acgttcaggt cgcgctgatt ccccgttgga ccgtaataat taaagccgta 3519661 gctgagctgg gcgtagccac cgatcatctg tgtcggcttg acgtgaatcc ttgtcgggct 3519721 gttatgggtg cctccgcggt tattcgtcag ctttgtgccg ggcacgttga tgtggcggtc 3519781 ctgggcatgg tgcataaacg ccattccttt aggaatccga tgagacaaaa cggctctcgc 3519841 gacgacaacg ccgtttcggt tgaagcattc aatccaatcg ttgtctttga tatccgtgtc 3519901 ctctgcatca tctttattca tccacacggt cggcccgccg cggaacagcg tcagcatcgg 3519961 cagagaatca aaatacatgc tgtggacaga ccatttatta tgcggcgtca aataattgag 3520021 gacgatttct tttccctctt gatcaggccg tttgctcaga aacgggcgat gctggaggat 3520081 cggtttgaat gtcgccatcg tttcaccgaa ttccatcatc agttcatgat cgacataata 3520141 ggattgtctg cctgtcagcg tccgccacgg aattaatttt tcaacattcg ttgtaaacgg 3520201 cgaatacctg cgccctcctt tttcagagcc ggtaaacgct ggagacgtga tcaccgtttt 3520261 cggctgggct gtaatttgtt cgaacgtaaa gcattcttcc tcgcgttctt ccgccaggtc 3520321 tttcagcttc aggttcgtga tgttttcaag tgattcccat gcttttactg cgacctttcc 3520381 attcgaagtg gatgataggg ttaaaatcgc ttctgcagcc tgctttgctt cacttatatt 3520441 tggacatccc tttgccacgc tgtccgaggt gatttctccc agtctctgtt tgagtgattc 3520501 atattcatcg gctattgacc agctcatccc ttttgttccg ctcggcttta aagcaacgtt 3520561 cggaccaagt gcagtcattt tatgaaaaat gtgtttgtaa tcccgttcaa cgacttggat 3520621 gttcggcatc gtttttcccg gaatggcttc acattcgcct ttgctccagt cattgatttt 3520681 gccgaatggc tgggccaatt cctgcatggt gtcgtggagc agcggtgtcg caaccacttc 3520741 tttcaccggc tccatatcga cttcttctgc cagatcggaa acggcttttg acagcgcctt 3520801 gaaaatatcc cagtctgact tcgattccca cggagccgag atcgcaggag caaatggatg 3520861 aatgaacgga tgcatatctg tgctgctgag atcgtgtttt tcataccatg tcgccgccgg 3520921 cagcacgata tcggaataca gcgccgtacc cgccattcga aaatcaagat tgattaataa 3520981 gtcgagcttt ccttccggcg cctgctcccg ccatttgatt tcttctgggc ggatgctgtc 3521041 gctgtcgtca ttcattaaac cgttcgttgt ccccagcaaa tgcttgagaa aatattcatg 3521101 cccttttcct gagcttgaga tcagatttgc ccgccataca aagagattcc ttgggaaatt 3521161 cacttcattg tcaggatctt caatcgcgaa tttcagtttt ttctcttgga gctgtgaggc 3521221 cacgtacgca cctacgtctt caggtgttgc tgcccctgct ttttcagctt ctttatacag 3521281 atcgatgcca ttttgattga aagtcgggta agacggaagc caccctagcc gcgccgccag 3521341 cacattgtaa tcagcgtggt gcttgtagcg ggatgaagca gcaatcggtg atgccaaatc 3521401 actgatcggc tggtcctcat aacgccactg atctgtcgca aagtagaaaa atgaggtgcc 3521461 attttgcagc ttgggcacgc cttcccagtc ctttgcagtt gcaatcgtct gccacccttc 3521521 agcaggtcgg agcttttcct gccccacgta atgggcccag cctccgccgt ttacgccttg 3521581 ggcgcctaca agtaaaacaa gatttaacac tgctcggtag atcgtgtcgg agttgaacca 3521641 gtggttaatg ccggccccta cgataatcat ggaccggccg tctgtatcga tcgcattttg 3521701 ggcaaactct ctggcaatct taacgacagc ttcttttttg attcctgtca tttgttcctg 3521761 ccaggcaggc gtaaacggct cagggtcatc ataggagaca gccgatcgtt cgccgatgcc 3521821 ccggttcacg ccgtagttag ccagtatcaa gtcaaacacg gtcgtgatgt acgtttcttc 3521881 accgttcagg ttcatttttt taataggaag atcccgctcg agcactttgt ttccgtcatt 3521941 tgaaaaatac gggatgcgca ccgtgccgat ttcgtcctct attcccagca cagagagacg 3522001 gggttcaatc ggttccccgg tttcttcatc aatcatgtgc aggttccatt tctgctgccc 3522061 gtcccagcgc gagcccattg tcccttgggg tatggcaaat gaacttgtct gttcatccca 3522121 aaccgcaggc ttccactgat catgctttgt cttccgcccg atgtccttcg catgcagaaa 3522181 ccgtcccgct gtgtatacgc cattttcttt tgacagagtg acgagaaatg gaaaatcagt 3522241 gtattgcttc gcgtactcaa taaaacgttc agtttcttgg ttcacgtaaa attcctgcag 3522301 aataacgtga cccatcgcca tcgcaagcgc cccgtcagtc ccttggcgaa tactcagcca 3522361 gtcatccgcg aactttgagg attccgcaaa atctggactg atcgaaatga ccttagcgcc 3522421 tttatagcgg gcctccgcca aaaaatgcgc gtcaggcgtt ctcgttaacg gaacgttgga 3522481 gccccatgtg ataatatagc cggaattgta ccaatcactg ctttccggaa cgtccgtctg 3522541 gtcaccccaa atttgcgggg atgctggagg aagatccgca taccagtcat aaaaactgag 3522601 catagggcct ccgattaacg acataaaccg ggagcctgat gcgtggctga tcatggacat 3522661 ggccggaatc ggagaaaaac cgacgtttcg gtcaggcccg tatttcatca ctgtatacag 3522721 cagagaggct gaaatcagct tcagcacctc cggccattca gcgcgcacaa aaccgccttt 3522781 ccctctcgcc tgtttatagg acttcgcttt ttcagggttt tcgacgatcg atttccaggc 3522841 ttccaatgga ttttgatgcg tctgcaatgc ctcccgccac aaattgatca gcacaccgcg 3522901 cacgtatgga tatttcacac ggagcgggct gtagatatac catgaaaaac tggccccccg 3522961 cgggcagcct ctcggttcaa aatcaggcat atccgggcct gttgatggat aattcaaatt 3523021 ttgcccttcc cacgtgacta ttccgttttt cacataaata ttccagctgc aagaccctgt 3523081 acagttgacg ccgtgggtgg agcgaacgac tttgtcgtac tgccatctgt ttctgtatac 3523141 attctcccaa tcgcgatcct cgcgggtagt ttggctatgt ttatttgaat ggtgttcgat 3523201 aggagagaaa taattcaatc tcctaaacaa cggactcctt ttctttttct tcatgagagt 3523261 tcactccttc cgagtcaggt gatgctaagt tcactataaa cagagacagc gtgtttcctt 3523321 gtgaactatg tcacacactc tgcttttttc acaaaatgtt cacacaaagg agaaggaagg 3523381 ctgcgttcag gcaggacgct tgggtcatta gctgcctttc attcaaagat caaaaaaaac 3523441 cggctctatt taagaaccgg gctcagcgtt ttcatcctgt gatgtatgca gataccgcaa 3523501 aaataattga taggaacaaa aaacattttg ctgaagcata gccaaaaagt tcatttgcag 3523561 ctgcggatga taagacatca ttttcttaaa tatgtaatat gggatgttga gaatcagaat 3523621 gtctgaagtg gcattgactg agataaaggg cgataaataa agcccgcctt tttcatcaat 3523681 cggaaacaca tcgccttttt cccacagcgc aacggttttc gacccttcag ggagccttgt 3523741 gtccataaaa cggacactgc cttttaatac aatataaaca gattgagaat gaagaaaaga 3523801 tggagactga tcacatgaac cgcggataaa cgtgccgttt ttcagcaagg tttcgacaat 3523861 ggatagaggc acttcattaa acataggaag ttgtttcaga aataataaat agtcacactg 3523921 attcatagga aaacctcctg tgctaaggat agctttagtg tagctcgact gagcctgtac 3523981 agcagtgatg tatttcacag cctgtatgat gaatgtcact tatcaggagg gtgaatgcat 3524041 ttataatgaa agaaaaaagg aggatttcga tgaaggcgct gattccgaag cagcacgggg 3524101 cgtgggcgat gctgctgatc ccatttttac tcggcatggt caagggaggc cccgttattt 3524161 ggcatattcc gctcttcctt ggttggcttt tcctatactt agcggtttat cccgttacgc 3524221 ttgccttaaa aaagaaacaa agcaaaccat atcaaaagtg gatgtgttat tacggttttc 3524281 ccacctgctg ctttttgatg atctcggtct ttcataagcc gcctctcatc tgggtgggcg 3524341 tttctttact gccgctgttt ctcatacata tgtattttgc ccgcagaaaa aacgaacgag 3524401 ccttattgaa tgatgttgca ggtgtcttgt tcttttgttc gggcgggttt gcgagctgct 3524461 ggctggggat gggaaccctt gacggctggg cttggtttat tttcttgcag tctgctttat 3524521 tttttatcgg gagttccttt tatgtgaaat cggtgatccg cgagagaaaa aacagggcat 3524581 ttgcatactg gtcatgggga tatcacctgc tgctcccctt tttatccgct cttttcggag 3524641 caggatgggc gtttctcgct tttatcccga gcagcttgcg ggcatggttt tttcatggaa 3524701 gggattggcc cgtaaaaacg attggcattc tggaaatcgt gaatgcctgc ttctttcttg 3524761 ccgtcatgtg cctgtttatc acaaggtaaa aaaacaagga caccgctgtc cttgtttttt 3524821 tcagtcaata ttgcaaatct ccagcgggca attttcacac tcaatctcac atcgtaaata 3524881 gtcccgcttg tgcaaaataa tttttccgga ttcgtctatc gaaataaccc cttttttgcg 3524941 gagatctccg agcatacgat tgacgctttc ccgtgcagcc gcgcaaaact ttgccaaatc 3525001 ctgatttgtc aggacaatgt taatcagaat gccgtcgctt cgctccactc cgtagctgtt 3525061 tgataagcgg ataagggtag aatagagcgc cccctttttg ccatgaagaa gcagatccct 3525121 gattttggac tgaatcttcc ggaggtgcgt gctcatccat ttcatgaact caaatgtcaa 3525181 agcgccgttt tggattaatt ctttttccag cttattttta ttaatgacga gcacctcgcc 3525241 atcctctagt acttttgcac tgagcatata ccttggttct tcagtgaaaa gtgttaattc 3525301 tccgacgata tcatgctttt ggcagattct aagcgtcagg tcttttccgt cagatgtcag 3525361 cttgccgatt tcaatgagtc ctgattgaat cagataaagc tcttctgcat ccattccttc 3525421 ccgaaacaaa tacgtgtgtt tttccatttt tcttttcgtg ctgatcgatt ccagcaattc 3525481 atacagatcg ctggatataa gatcactatc agatggtcga acagagagaa aattcatgag 3525541 ctcacctcga agaaagtcac gttgtgtgtt tattgtaacg tgaattgatt tgtacccatc 3525601 gagaaaaaac taacaatctt gtgaatgccc cagtgttagt tgatgctctg gctgtttctc 3525661 tccgtgtgtg ttttcattct ttcctgccaa tacatccata tgacaaggac aaaactggct 3525721 aacgccacct ctgaaagcgc cataaacccg atcgcgtact ggcctgttgc ctgaaataca 3525781 ctcgccaata tgagcggagg aaaaaagccg cctaaaccgc ccatggcaga cacaatccca 3525841 ttggcaatcc ccgcttgctt cgaaaaatag aaaggcacca gtttaaaaac agttccgttt 3525901 cctatgcctg agcagacggc cacggttaat gatccaaacg tataaaggcc gattgtcggc 3525961 gagaacgata ggataatgcc tgataatgta agcccggcaa aaacaaacat caagatgcgg 3526021 agcgggctca ttttatcagc caggaatccg cccgcaggcc tgagcagcgt agaaaccgca 3526081 ataaagccag ccgtccgcaa gccggcatct gcaggattca gcccaaaatg ctccaccaga 3526141 aagttcggca gatagatagt gaaggcgaca aaggcaccga acgtaataaa ataaaacagg 3526201 ctcagaaacc atagcacatg atttcggtaa acagctttga tttgagtctt aacagaaact 3526261 ttgaccttct tctcatgcct gtcgccaaac aatacgtgca gtaaggcaaa gacagccagc 3526321 aaaatcagat acatttgcac ggttgatttc cacccgacgg cttgagcgat aaccggcgct 3526381 gcaaatgtcg taacggctgt cccgatattt cctgcaccgt aaatcccatt gacgacaccg 3526441 tgcttttctt tcggataata tttcgggagg gaggtcaccc caatggaaaa caccgctccc 3526501 ccgatcccta agaaaaagcc gcctgcgatt aaatcaaaca gagaatccgc gatactgatc 3526561 caaaatacag gaaataaaag caggatgaag ctgaccataa acatgagccg cgcgccaaac 3526621 ctgttcgtta aataccctaa aggaatgcgg agaagcgacc cgaggatcac aggaatcgcg 3526681 gtcactaaag aaatctcacc cttgcttaaa tgaatatcta atgtgatttg ggaaatgagt 3526741 gatgaaatca gcacccaaac cataaaccct gccaccaagc ttaatgactg taacgataat 3526801 tgaatgtgtt gacggttgat catttggctt gcccctttca atgattcaat aatcagtctt 3526861 atcatacaaa aactagccaa acaggattgt gaattacatc acacgttttt ctcataaaaa 3526921 aaggacaaag cccgaagact ttgtcctttt gatcgtgatt acattttttc cggagccgat 3526981 acgccgatca gctgaagcgc attgttcagc gtaatttgcg ttgccttcat taaagccagg 3527041 cgcgcgcggc ttttctcttc attttcaggg tcgatgactt tctctgcgtt gtagaagctg 3527101 tgcagagcag aagccagatc ataaatatag ttagtgacac ggtgcggaat tcgtttttcc 3527161 gctgcttccg ccactgcctc tgggaagccg ccgatcgttt tcagcagatc gtattctttt 3527221 tctgattgaa tatggctgaa atcaagatct gccgccggtt taagcccctg ctcttcccct 3527281 tggcgaagca tgctgcaaat acgggcatgc gcgtattgtg cataatacac agggttttcg 3527341 ttagatgttg atacagcaag atctaagtca aaatccatat gggtgtctgc acttcgcatt 3527401 gcaaagaagt aacgcacggc atccaagccg acttcttcaa tcaggtcacg catcgttacg 3527461 gctttaccgg tccgtttgct cattttcatt ttctcgccgt ttttgtaaag gtgaacgagc 3527521 tgaatgattt ctacttcaag cgttcctttt tcatagccca gcgcttcgat tgccgctttc 3527581 atacgcggga tgtagccgtg gtgatcggcg ccccaaacgt tgatcagctt atcaaagccg 3527641 cggtcaagct tgtccttatg atacgcgata tcaggaagaa ggtacgtgta cgtgccgtcc 3527701 ttcttgatca atacgcggtc tttatcatcg ccgaaagtcg tggaacggaa ccaagtcgcg 3527761 ccgtcttctt catagacgtg gcctttttcg cggagcgctt caagcgcctt gtcgattttt 3527821 ccattttggt acagtgaagt ttctgaatac cacacatcaa acggcacacg gaagttttcc 3527881 aagtccttgc gaagcttttc cagctcgtat ttcaggccgt attcacggaa aaacgcgagg 3527941 cgttcacttt cctcttcgtt aacgaaacga tcaccgtatt cctcagcgag acgctttccg 3528001 atcgcaatga tatcctcacc gcggtagcca tcctccggca tcggtttttc caatccgagt 3528061 gcttcaaagt aacggacttc aacagaaagc gccagattgt tgatttggtt tcccgcatcg 3528121 ttaatgtagt attcgcggct tacatcgtaa cccgcttttg aaagcacgtt gcacaaggaa 3528181 tcgccgacag ccgccccgcg cgcatgcccg aggtgaaggt ctcccgtcgg attcgctgat 3528241 acgaattcta cctgaactcg ttcaccgttt ccgatgttcg tttccccgta tgcttcccct 3528301 gcttccagta cagacggaat cagctttgtt aaatattgat tgttcatata gaaattgata 3528361 aaacccgggc cggcgatatc cagtttttca atcgaagcct tccctttatc aaaatgggcg 3528421 acaatctctt cagcgatttg acgcggcgct ttttttgcca ctcttgccaa ctgcatcgcc 3528481 atattcgttg agtagtcgcc gtgtgtttta tctttcggtg tttctaaaac aacattggga 3528541 atctggcttt cttcagccag tcccgctttc agaacggccg ctttgatttc ttctttcagc 3528601 acgtccttca tttgttccgc aatgttcatg cgtgagttcc tccctcatac gtgatcgtca 3528661 tattatgtaa atgctcctgc tcgtctccga catgcatgtc atatgcgatg ctgatacggc 3528721 ctttttcttc atcgagatca gattgaatcg attttgtgct tgttttcagc tcaagctcac 3528781 caaatgacat tttatattta gcaattgtgg aagctcccgt tacgaaacgc tgattcattt 3528841 tgacagcgcc tgacctcatg accaggactt cgccttcgct tactttcaca atcgttttga 3528901 ctttgcctaa gtcgtgttct tcataataag atagatacac tttattttgt tttacatagt 3528961 aaaatccggt ggtgcggaat tcgatgactt cttggtttcc gtcatcctcg atcacagact 3529021 tcacatggag tgttatcggt gtctcttgct tcattctgac acgtcctttt catcattcca 3529081 ctttgacttg aatagtataa tcattcggtt tgtaaacttc aactgcttct atcttaccat 3529141 cattgctcat cagatttgaa gataaacctc ataaaaagca tttccttata tagaagagaa 3529201 aatcatatca ctaattacct ttaggaaatg ttacattttt ccgaaatcta tcatttcctt 3529261 ttcacatttt tttcaaaata tatgtattga attagtaatt tgatagtttt aagataaaag 3529321 tacaacatag atctgctaga aaaacaaaaa aagggaggat tcaattatga aaaaagctgt 3529381 cattgtagaa aacaaaggtt gtgcaacatg ctcgatcgga gccgcttgtc tagtggacgg 3529441 tcctatccct gattttgaaa ttgccggtgc aacaggtcta ttcggtctat gggggtaagg 3529501 atctcccaaa agggcatagt cattctacta tgcccttttt aagtaaatta caatttttaa 3529561 ctaaaatcta cctcttggat atacatacac aaccgttttt catttgaatc atatgtatag 3529621 gggatggtat tttgtttata gagcagatgt ttccatttat taatgaaagt gtaagagttc 3529681 accagcttcc tgagggcggc gtgttagaaa tcgactactt gcgcgataat gtctccattt 3529741 ctgactttga gtatttggat ctcaacaaaa cggcttacga gctctgcatg cgcatggatg 3529801 gccaaaaaac agctgagcag attttagctg agcaatgtgc agtgtatgat gaatcaccgg 3529861 aagaccataa agattggtat tacgacatgc tcaacatgct ccagaacaag caggttattc 3529921 agcttggaaa ccgggccagc cgccatacaa tcaccacgag cggaagcaat gaatttccga 3529981 tgcccctgca cgccaccttt gaactgacgc accgctgtaa tttgaaatgc gcccactgtt 3530041 atttggaaag ctcacctgaa gcgctcggca ccgtgtcgat tgagcaattc aaaaaaacgg 3530101 ctgatatgct gtttgataac ggtgtattga catgcgaaat cacaggtgga gaaatttttg 3530161 tccatccaaa cgccaatgag attcttgact atgtgtgtaa aaagttcaaa aaagtcgctg 3530221 tcttaacaaa cggaacactc atgcgaaaag agagcctgga gcttttgaag acttacaagc 3530281 aaaaaatcat cgtcggcatt tctctagata gtgtcaattc cgaggtccat gactccttta 3530341 gagggagaaa aggctctttt gcccaaactt gtaaaacgat aaaattgttg agtgaccacg 3530401 gtatatttgt cagagtcgct atgtctgtct tcgaaaaaaa catgtgggaa atccacgata 3530461 tggcccaaaa ggttcgggat ctcggggcga aggcgttttc ttacaattgg gttgacgatt 3530521 tcggaagagg cagggatatt gtccatccaa cgaaagacgc cgagcagcac cgcaagttta 3530581 tggaatacga gcaacatgtg attgatgagt ttaaagatct gattccgatt attccctatg 3530641 agagaaaacg cgcggcaaat tgcggcgctg gctggaagtc cattgtgatc agtccgttcg 3530701 gcgaagtacg tccttgcgcc ctctttccaa aggaattttc attgggaaat atttttcatg 3530761 attcctatga aagcatcttt aactcccctc tcgtccataa actgtggcaa gcgcaagcgc 3530821 cgcggttcag cgaacattgc atgaaagaca aatgcccgtt cagcggctat tgcggaggct 3530881 gttacttaaa agggctgaac tctaacaaat atcaccggaa aaacatttgc tcttgggcga 3530941 aaaatgaaca attagaagac gtggtccagc ttatttagga gggaaacgat ttgtcaccag 3531001 cacaaagaag aattttactg tatatccttt catttatctt tgtcatcggc gcagtcgtct 3531061 attttgtcaa aagcgattat ctgtttacgc tgattttcat tgccattgcc attctgttcg 3531121 ggatgcgcgc gcggaaggct gactcgcgat gagcattttg gatatacacg atgtatccgt 3531181 ttggtatgaa cgggacaacg tcatcttaga acaagtggat ttacatttag aaaaaggcgc 3531241 cgtttacggg ttacttgggg taaacggcgc cggaaaaacg acactgatta atacgctgac 3531301 aggcgtgaac cgcaatttca gcgggcgttt tacactgtgc ggaattgaag cggaggccgg 3531361 catgccgcag aaaacatcag atcagctgaa gactcaccgt tacttcgccg ccgattatcc 3531421 gctgctattt acagaaatta cggcgaagga ctatgtgtct ttcgtccatt cgctttatca 3531481 aaaggatttt tcagagcagc agtttgccag tttggccgag gcctttcatt tttcgaaata 3531541 catcaatagg agaatttcgg agctgtcctt ggggaacagg caaaaggttg tattgatgac 3531601 aggcttattg ctgcgcgctc ccctgtttat tttggatgag ccgctcgtcg gtttggatgt 3531661 ggaatcgata gaggtctttt atcagaaaat gcgtgagtac tgtgaagcag gcggaaccat 3531721 tttgttttct tctcatctgc tcgatgtcgt gcaaagattt tgtgattatg cggctattct 3531781 tcacaacaaa cagatccaaa aggtcattcc gattggagag gagaccgatc tgcggcggga 3531841 atttttcgag gtgatcggcc atgaataaca taatccctat catgtctttg ctgttcaaac 3531901 agctttacag ccggcaaggg aaaaaggacg ccatccgcat tgccgcaggc cttgtcattc 3531961 tggccgtgtt tgaaatcggg ctgatccgcc aggccggcat tgatgaatcg gtgttgcgca 3532021 aaacgtatat catactcgcg cttcttttga tgaacacata tatggtgttt ctttccgtga 3532081 catcacaatg gaaggaatct tatatgaagc tgagctgcct gctgccgatt tcttcacgga 3532141 gcttttggct cgcccagagt gtcgttttgt ttgtcgatac ctgtttgaga agaactttat 3532201 tcttttttat tttaccgctg ttcttatttg gaaacggaac gctgtcaggg gcgcaaacat 3532261 tgttttggct cggcaggttt tcgtttttta ccgtttactc cattattttc ggagttgtgc 3532321 taagcaacca cttcgtcaaa aagaagaact tgatgtttct gctgcatgcg gcgatattcg 3532381 cctgtgtatg tatcagcgcc gctttgatgc cggccgccac gattccgctt tgcgcggttc 3532441 atatcctgtg ggcggtggtc attgactttc ctgtctttct gcaggcgcct ccgcagcagg 3532501 gcaagatgca ttcatttatg cggcgatctg aattttcgtt ttacaaaaga gaatggaacc 3532561 gatttatctc ttctaaagcg atgctgttaa attacgcggt aatggcggta ttcagcggct 3532621 tcttttcgtt ccagatgatg aacaccggca tcttcaatca gcaagtgatt tatatcgtga 3532681 tttccgcgct tttgctcatc tgctcgccga tcgccctttt gtattcgatt gaaaaaaatg 3532741 accggatgct gctcatcacg cttccgatca agcgaaaaac gatgttttgg gcgaaatatc 3532801 gcttttattc aggcctattg gcaggcggat ttctccttgt cgtgatgatt gtgggtttca 3532861 tcagcggccg ttcgatttca gttctcactt ttttgcagtg cattgagttg ctgctggcgg 3532921 gagcgtatat caggttaact gcggatgaaa aaaggccctc cttcagctgg cagacggagc 3532981 agcagctatg gagcggtttc tcaaaatatc ggtcttatct gttttgtctt cccctattct 3533041 tagccatatt agccggcacc gctgtatcct tggcggtcat tccgatagcc ggtctggtca 3533101 tagtctatta cctgcaaaaa caggatggtg gtttctttga tacaagcaaa agagaacggc 3533161 ttggaagtta acctgctgaa gactcatcaa ttttcaacta tttcaatcgc cgcgagcttt 3533221 ctgaaaccga tcgaaagcgc ggcggaacct gaggaagaaa cgatttattt ttacggcgcc 3533281 gccgcatacc tgaaggagca aatcattgac gcttttggtt atgctgccgg cagccgtttc 3533341 atgtactcag cgaatctctt ttttgatcag cagctgaaaa cctgcgggac ccgtttgatt 3533401 cacccattat ataacgggaa tcttcatgtt gacgccctga tgaaaacttt tgcagacttg 3533461 tctttccctt cttctctttc attcgaagca tttgaaaagg ccaggaatga gctgctgctg 3533521 aaaatcgaaa agaaattcac tgatcccttc tcctactcgg cggctcgctt ggctgaggag 3533581 gtcttcggaa acccgatgta cggcacaggc atgtttggcc ggagagacag gataaaggcg 3533641 attcatccta aacggtttct cgacgcaacg gactttatcg ttgatttagt gtcccagcaa 3533701 aaacagctga acatattggg acaagtacaa gcatgtgatg ttcggggaca tgccccgcaa 3533761 acgtccgctg taacgtccgg aagaataccc gtaaaccggc atgtttttga aacagagaca 3533821 cgcagcgctg caggtccttc cgtcttgaca ctcggatttg actgcggaga gatgaaagat 3533881 gccagcgatt atatcaaaat acagctaata gacggattac tgggaaagta cggccattcc 3533941 gctttattca agcacttcag agagaaggat ctggcagtct atcacgttat cacccgttac 3534001 gatgtcatga acaatttgct gcttgtttca atatgtacag atcagcttca tgagaaagac 3534061 attcccccgc gcgttttgga agctgtctca gcttttcata cagatgagcg ggaactagaa 3534121 caggcaaagc agtttttacg caatgaattg ctgctgcaat tcgattctcc cgaaggtcta 3534181 ttggcctata tgggggtcct gcgccgcttc tcctgcacga aagaagcctt gctggatggc 3534241 atctcagcgg ttacatgccg tgatgtattg caattcatag cgaccatcaa ttatatcgga 3534301 gctcatgtag taaggggatg aagagatgga aaagaaagcc ttttttcaac agctggatga 3534361 acgaaccgat atcagataca cagacagcgg actaaaaata ttcagattga aattcccccg 3534421 cgcccacctg cggctgtgca atgtaaaaat cgattttgga agccgggatg tatgtatacg 3534481 ggcagaatcc ggtgatacac tgcttccgta tggcacagca cattttttag agcatcttct 3534541 cttctggcat aacggccgca atctgtacag tgattttttt gcgcatggcg cgcttttaaa 3534601 cgcattcact acctacaccg ataccaattt catgtttacc tcattaccgg atcggctcag 3534661 acaaacgatt cccatcctgc ttgatgcttt atggaaccac tcatttgaca agaagattgt 3534721 cgctcaggaa aaagctgtga ttacaagcga aattcaaaca gcacacctta accatcagct 3534781 ctcatatcat tatcagctga tcagcatgct ttctccctcc tcaccagctg ccgttttccc 3534841 cgcaggcaga atcgaagata ttgaggcgct ggacatcagt gatttacaaa aagcctataa 3534901 ggctgcctac caagcccatc ggatgacgct gtttttgatt gggggctcag aaaatacaga 3534961 aacgcttttg cctcctcacc tccagctgga aaagcgtccg gattatcatg ctgaaagaaa 3535021 aatcatcccg gcatgccctc cagtcctctc acaaaaaatg atgctgggtg atgaggagcg 3535081 gatggaagat acctggaccg gattacagat cggcgcactt cccgggcaaa acgatctgtt 3535141 gtcgataaag ctttattggg atatcgcggc tcgtattcta tttcaattag attcaccgtt 3535201 ttttcaagag attcagcaaa cgtaccgcct ggaaatcgat cgcttgtcag ccgagactta 3535261 tatatatgag gatggcggtt tcttgatcct tcacagtcaa gggacccatt cttcagctta 3535321 tatcgatgtg gcttcatact atgtcacaca gaagaaagaa caggttgccg cctggcttca 3535381 atacggcaag gactctttga cagacgcgat catttatgac agcgattatg tgcgtaaatg 3535441 cttcgagtgg gcagccgagt gtgacaggtg cgattgctcg tttcttgaca tgtaccacat 3535501 cattcaagat atggatgcgc aggttttctt gtctctcatt gatgcaatgg catcttctaa 3535561 caaagcgatc attcacgttt ctcagaaaga ggcgatcaga caatgaaaca aagcactgtc 3535621 tttacccttt tattgctgct tataggtatg gcggcttatt ccttcggctg ggttcaggcc 3535681 gttgccgaag ccgccgccca atatgtacag atgatcaaca atgatgctgt gcggctcgga 3535741 ctgctggctt gtaccgctgc cctcctgatg ctgcctgctt ttctctatct tcactatgtc 3535801 acccaatccg tgaaaaacat gacagcagct tttcagaaac tcacacagtc tcatcaaagc 3535861 tgctgtgact ttcagcaaca caacttgtgc agccgatatg cagaagacgt caaatcgctg 3535921 cgtgacagct ataaaaacgt ccgccaaaca tacgtgatgg ctgccgtgtt gtgccaagtc 3535981 atcatattcg gctgcatgtt cgaaatcgtt aaagccgtcc ctttccgcct tcatacgccc 3536041 cctgcctttt caatgggact tgcgatgcta ctgatcctgt atttattgtt ttgcatgcga 3536101 acgtatttgc ggcagctttt ccggcacggc agcctgttca gaaaagtgtt tgcgggagca 3536161 ctggcagcag ccgggatttg gtggatgctc agtttctcta taagtgaact gctgtttctg 3536221 attatcctgg ctgccattca gcaaatcgga tcatttattt ataaacgatt ctcttatcac 3536281 agcaccgctt ctcttgatct ataaaatagc tacatcgcaa tcgcagacgg acccgcgcca 3536341 accggaatca ccgtcacggc tgtataatca cttgtgcggt acacggtcac agcattgtcg 3536401 ttgggctgtg ccgcataaat atactgtttg tccggcgtta cggcgaggtc aaaggcgccg 3536461 gggagagaca cgtttgcaat gatcctctgt ctggccgtat taactacgta taagttatta 3536521 atgagaaacg gttcactata tggctctaga aaataagctc tagtactatc gagagaaaat 3536581 acaatcgtcc tcagcgtttc aaataaacgg ctgaagtccc ctcccctgct taatggtgac 3536641 aaactaatct ccgttacacc tttcggccac agctcaccat tcaatacgta cgcaaaattt 3536701 ccagcgtaag gagttgtaat taaactggga aattcaaatg tatctatgat actttctacc 3536761 aactgcccag tatttacatc atatttatca accgaccaac tgcttccatt agcggtatag 3536821 acatactgtc cattcggatc aagagcaaag tctaaagcgc cgggtatcgg aatgacatca 3536881 atgaccgatt gagaggccgt gttaatcaca tatatagatc cggcggccat cacgtatgcg 3536941 aactcatctg ttggatcaaa ttcgattttt ctcggccctc ctccaacagt aatggtattt 3537001 atgatggtta atgttttatt atcaatcact gagacaaggt tggtatttcc atggaggaca 3537061 tacgtgaatg ctttatcgaa agtaacgcct agattagttg gcacgtcaga aaaagggatt 3537121 gtttttacaa cagtgtttaa atctgcatca ataaccgaaa ccgtgctgtc tccagtattg 3537181 gcagtaaaca catacgattg agggtctggt gatggcggta aaacaagtgt cccggccacc 3537241 gtaagcggac tgccgtagaa aggcggtaca atgagcagat cttccactgt tatttgactg 3537301 aaatcaggac agcggccaga ctgtgctgca taataaacaa cttgatcaat ctcttcagta 3537361 tgaatcacag aaacagcccc gtctccttgt ccatattgat ttcgtacagg cgacacactg 3537421 acaagaagcg taatggtccc ttgtactctc acagcatatc gaacaccgat atcttctggt 3537481 tccggcccag tctggattaa gcaaggctca ctgatacagg acaaattgtc tgtactccat 3537541 gtaacagccg ctgacgcttc ggccgtatca accttgaagc cctcagggaa atctatcggc 3537601 acttgaaacg gcgcttcccg gctaatttcc tcatcacaaa aacagaaaca attttcctgt 3537661 aaagcagaaa gatcattctt tttcatgatt tcacgtcctt ttagaaatgc acaacatgca 3537721 gcggttaaat cgtaatggca cccggtgaaa ccccaagaga tatcacagtt tcctcagaat 3537781 aatcatctgt gttgtaaaca atgatgctct gctctataaa acgagttgca tacagaaaat 3537841 cgccattcgg ggtaaacgca tagtctgttg ctgattgcgg aacatttcct ataacgcctg 3537901 ctccatttgg actgacagaa tataaattgc cagtgaagcc gtcatataaa tacacctctg 3537961 ctccactcgt aaacattcga tattcccctt catactccag ctcttgggtg ctgctgatgg 3538021 taaacgtatt taaatcaata accgtcaaat aattaaaaaa gaattcttgt tctaatacat 3538081 aggcataccg ctccggccaa tttgtttcta tggttgatac gataagctct cgttcaattg 3538141 ttcctgtgac ttcaccggta gttaggtcca ctttttgcac tattccaaaa ttcagaacat 3538201 aggcgaataa cccattggga tcgattgcaa catcatatcc ttccacagga atcgacctat 3538261 ccacagttaa cgtatcaatt ccaatcacat aaaccgcagt accggtgaaa acataagcaa 3538321 actcatgatt agggataaat ctaatcaatc gaggcggctg atccagcaat atagttgctg 3538381 tcactgttaa tgtgtcataa tcgatgacag aaatcacatt attgttggga tgtaagacaa 3538441 acacagcgct tttatctggc gtaatttcaa tacctgccgg attgtacgga agagcaatcg 3538501 ttgtcacaac agtatcggtg tttgtatcaa tcacagaaac tgattgatca tttggattcg 3538561 ctgtaaacgc gtagacgggt tccggctccg gtacaagcac aattgtcccc gtcaccgata 3538621 aaggactgcc gtaaaacggc ggaacaacaa caaggttctc aatcgtgatg tcactgatat 3538681 ccgggcaatc atccgattca tcggaataat agacgacttg atcgatttct gcattgtgaa 3538741 tgacggaaac agccccgtcc ccttgtccat attgatttcg gacaggtgag acactgacga 3538801 gtagcgtaac ggttccctgc aggcgcactg caaattgaac accgacctca tcaggctcag 3538861 gccccgtttg aattaagcaa cggtcactga cacaagaaag gctgtctgca ttccacgtca 3538921 cgtttgcaac agcttcagcc ggatcaacga caaacccttc aggtaattca atcggtgctt 3538981 gaaacatggc ttctcggctt gcttctccct cacaaaaaca taagcactct tcttgttctg 3539041 ctcctgcttt ttctttaaag gaaagcttgt tttttctcat tccttcactt ccttttcaga 3539101 catacactgc tcacgcagat ataacagaat atggaagggt aacgtgtttg cttgtacaaa 3539161 ttgctgaggg taaacgcttc tttttgaaaa tatatctcca aacatgcggt gtaacgaaag 3539221 aaaaaattgc ggtttttttg cgcttctcac aagaatgttg atgataaaat atgacatata 3539281 tagaattatg aagggaggga tttgcaaacg tgacaggtgt catatcttct tcttccatcg 3539341 gagaaaagat taacgaatgg tatatgtaca tacgccgatt cagcataccc gatgcagaat 3539401 atttgcgacg agaaatcaag caagagctgg atcaaatgga agaagatcaa gaccttcatt 3539461 tgtactattc actgatggag tttcggcaca acctaatgct tgagtacctt gaaccgttag 3539521 aaaaaatgag gattgaggaa cagccgagac tgtctgatct gctgcttgag attgataaaa 3539581 aacaggctcg tttaactggt ctgcttgagt actattttaa cttcttcaga ggcatgtacg 3539641 agctggacca gcgggaatat ctgtcggcta ttaaattttt caaaaaggcc gaaagcaagc 3539701 tgatattcgt taaggatcgg atagagaaag ctgagttttt ctttaagatg tctgaatctt 3539761 attactatat gaaacaaacg tatttttcaa tggactatgc acggcaagca tatgaaatat 3539821 acaaagaaca tgaagcttat aatataagat tgctgcagtg tcattcttta tttgccacca 3539881 attttttaga tttaaaacag tatgaggatg ccatctcaca ttttcaaaaa gcttattcta 3539941 tggcagaagc tgaaaagcag ccccaattaa tggggagaac tttgtacaat atcgggcttt 3540001 gtaaaaacag ccaaagccaa tatgaggatg ccatacctta tttcaaaaga gcaatagctg 3540061 tttttgaaga atcaaatatt cttccttcct tacctcaagc gtatttttta attacacaga 3540121 tccattataa attaggaaaa atagataaag ctcatgaata tcatagtaag ggaatggctt 3540181 attcacaaaa ggccggagat gtaatatatt tatcagagtt tgaatttttg aaatctttat 3540241 acttatcagg cccggatgaa gaagcaattc aaggattttt tgattttctc gaaagtaaaa 3540301 tgttgtatgc tgatcttgaa gatttcgcta ttgatgtggc aaaatattat catgaacgta 3540361 aaaattttca aaaagcttct gcttattttt tgaaggtgga acaagtaagg caacttattc 3540421 aaggaggagt gagtttgtat gaaattgaag tctaaactat tactctcttg tctggctcta 3540481 agcactgtgt tcgtggcaac aactattgca aatgcaccta cacaccaaat tgaagttgca 3540541 caacgaggaa tgatttaacc gccgtccatc ggcggttttt tcgtcccctc tttaccaaag 3540601 tctcccaatc catgctatga tcttttcaat aatcttgaag agagtggaaa tgcagcatgt 3540661 ctctaaaaag tgtgagaacc cactttactc aatggaatcg agaaaatgat gtgacggagt 3540721 tcgaaacgtc gagtgcgaca gttgaacagg cagctgagac aatcggcgta agcctgtcta 3540781 gaatcgccaa gtccctgtcc ttcagagggg aaggagatca ggtgattctg attgtggcag 3540841 ccggcgatgc caagatcgac aacaaaaagt ccaggcaaac atttggcttt aaagcaagaa 3540901 tgctctctcc taatgaggtg ctggagcaga caggccatga aattggagga gtttgcccat 3540961 ttggattggc tcatgatcct gaggtttatc ttgatgtatc gctgaaacgg tttcagactg 3541021 ttttccccgc atgcggcagc agaaactccg ctattgaatt aacaccgaaa gaattatccg 3541081 aattttcttt ctcaaaagtg tggattgatg tttgtaaaga ctgggaataa aaaaacatcc 3541141 agacatcgtc tggatgttta cttatttcac aaacccaagc agcatttcac ggatgatttt 3541201 gctggctgtg tttgccgttt gctctgagtg gtcgtatacc ggcgcgactt ccactaaatc 3541261 agcgcccttt acgtttacct ctgaacgcgc aatttcatgg accgatgcaa gcagttcttt 3541321 agacgtgatg ccgccggcgt caaccgttcc tgtacccggt gcgtgtgcag ggtctaatac 3541381 gtcaatgtca attgtgacat aaaccggacg gcccgccagc ttcggaagca cctctttcag 3541441 cggttcaagc acttcaaatt ttgagatgtg catgccgttt tccttcgccc attcaaactc 3541501 ttctttcatg ccggaacgga ttccgaatga atacacattg tgcggtccga tcaattctgc 3541561 cgccttacgg atcggcgtgg agtgagaaag cggttctccc tcataatcaa cacgaagatc 3541621 tgtatgtgcg tcaaaatgga taatcgcaag gtctgggtat ttcttgtaca tcgctttaat 3541681 gacaggccat gacacgaggt gctccccgcc catacccatt gggaacttcc ctttttctaa 3541741 aatgctgtcc acgtactctt caatcatatc caggcttcgc tgcggatttc cgaacggcag 3541801 cggaatgtcg ccagcgtcaa agaagttcaa gtcagccaga tcgcggtcta aatatgggct 3541861 gtattcctca aggccgattg acacctcacg gattctgctt ggaccaaagc gtgagcccgg 3541921 gcgatagctg actgtccagt ccatcggcat gccgtaaaga atggcgtccg cctcttccca 3541981 ctcgggacgg ctcgcgataa atacttttcc tgaataagct tcatcaaatc tcatctataa 3542041 taccctcgct ttcctgtaaa aaagcgcaag attcgctcct gcgccatacc ttcattattt 3542101 aatcaggtca ctcacaaatt tcggcagaac aaacgccgct ttatgaatat cttttgtgta 3542161 atatttcgtc tcaatatcga agaaacggct gtcttccact gcaagcggat catatttttt 3542221 cgagccaatt gtaaatgtcc acaaaccgct tggatatgtc ggaatgttcg ccgtatacag 3542281 cttcgtaatc gggaagattt ccttcacgtc gcgctgtaca tttgtgatta attccggtgt 3542341 aaaccatggg ttgtccgtct gcgcaacgaa aataccgtct tctttcagcg cttttgcgat 3542401 tcctgcgtag aatccttttg taaacaggtt tacagccggt ccgactggtt cagtcgaatc 3542461 taccatgatg acgtcatatt gattttcaga ttttgcaatg tgcataaatc cgtcatctac 3542521 ctgcacgtca acgcgcggat catccagttt gcctgcgata gaaggaagga actttttaga 3542581 gtattcgata accttgccgt caatatctac aagtgtcgct tttttcacgc ttgggtgctt 3542641 caggatttct ctgataacgc cgccgtcacc gccgccgact acgagaacgt gctccggatt 3542701 tgggtgcgtg aataatggga catgcgccac catttcgtga taaacgaatt cgtctttttc 3542761 agatgtcatc accatgccgt ccaaaaaaag catgttgccg aactcttctg tttccaccat 3542821 ttctaaatgc tgaaactccg tttgttctgt atgtaacgtc ttgttaacct tcatcgtaat 3542881 gccaaagttt ttcgtctgct tctctgtgta ccaaagttcg ctcaattgtc atctcccttt 3542941 cgaggctgta ttcatttatt gtaagcgtct tatcagcttt tattctcggt tgaaatctca 3543001 ttttcaccta aggaaaaagt atagaggatg gcggggaaaa agtaaagatg cgtcctgttc 3543061 tgcgatgttt aaaaacgatc tttttttctc ataatagtag aaacataaaa aaagggggaa 3543121 cccgttgtgg atgcaatgac aaataaacgg ctgagactga cgctgaaaac cgttcgcgcc 3543181 tttatctttt taggggcttt tgcggccttg gcggcagctg ctgtgtttat gactgtcatt 3543241 ttgatagcca aataccaggg cgctccctcg gtgcaagtgc cgcaatccac gattttgtac 3543301 gcgagtgacg gctcaaagct cggggaaacg aactacggcg aaaagcgcta ttgggtcccc 3543361 ttaaaggaca tgaatccgac gatcgtaaaa gcgacagtgg cgattgaaga ccagaatttc 3543421 tacgatcatc acggctttga ttataaacgc atggccggcg cggcgcttgc tgacctgaaa 3543481 gcatttgcca aggttcaggg tgcaagcacc atcacccagc aatatgcgag aaacttatac 3543541 cttgaacacg acaaaacgtg gaaacggaaa tggaatgagg cgttctacac gatccgtctg 3543601 gaacaaaact attctaagga cgagatatta gaaggctatt taaatacgat ttactacggc 3543661 cacggcgcct acggcattga agcagcttcc cgcctgtatt tcggcaagca tgccaaaaac 3543721 ctgacggatg cggaggcggc gcttttggca ggaatcccga aaggcccttc cggctattca 3543781 ccgtatgtca atgagacgaa ggccaaggaa cgccagaaaa cgattgtgcg gatgatggaa 3543841 aagcagcaga tgatcagcca aaagaaagcg gatgaattga tcaaggaacc tctttcctat 3543901 cagcctttga ataaacaagt ttccaagaga aaggctcctt atttctacga caatgcgatg 3543961 agagagctgg aaaaaaagct cggcatgaca cgggagcaaa ttgaaacgag cgggttaaac 3544021 gtctatacaa cggtagataa acggatgcag cgcatcgccg aggagaccat taccgaaacg 3544081 gttaacgcgg gctctgacat tcaagtcggg ttttcagcca ttgatccccg caccggaaac 3544141 gttctcgccc ttgtcggcgg cagggattat caaaaaagcc cgtttgaccg gacgacacag 3544201 gcgaagcgcc agcctgcttc gacgatcaag ccgttgctgt actataaagc gattcagagc 3544261 ggatttacgc cagtcacttt gatgaaaagc gaagaaaccg agtttcaaat tgatgcaaag 3544321 ggagaaacct attctccaag caactataac ggatactatg ccaacaagcc gattacgctt 3544381 ctgcaggcgc tggcgctttc cgacaatatt tacgctgtga aaacgcatct ttttctcggc 3544441 acgaacaaac ttgtaaagac ggcaaaggaa ttcggcatta ccgcccatct tcaagcactg 3544501 ccgtccctgg cactcggcac cgaacccgta cgtccgattg agatggtcaa cgcctatgcc 3544561 atgctcgcaa atggcggaaa gaaaatcgaa ccgactttta tttcaagagt aacggacgca 3544621 gccggccacg tgctgtacga aaacccgaat cagcataaac aggtgcttga tgaaaaagcc 3544681 gcttttgtca cagcgagtat gatgacaggc atgtttgata tcgatttaaa tggatatacg 3544741 tcggttacgg ggcgaacgat agccaaccgc ctgacaagaa cgtatgccgg aaaatcagga 3544801 accaccagcg cagacagctg gatgatcggc ttcaatccga agctggccgc cggtgtttgg 3544861 accggctatg acaaaaacag caccatcgac tcggtcgaag aaaaaagcta tgctaaaacc 3544921 atttgggcgg acttcatgga ggacgcgctc aaaggcgaac cggaaaccgc gttcaagccg 3544981 ccaaaaggcg taaccggtgt gtacattgat ccggaaacag gctactcatc aggtcccggc 3545041 tgcgccgcta agcattacac atattttgtg aaagggacag aacccgcaaa cgtgtgctac 3545101 ggggcagaac ccgcaaaaca aacaaaagac cggcttccat ccaaagaaaa gcccgcttcc 3545161 gagaaaaagt ggtgggacaa atggctgggg cgacatcatt gaaaataacc cggctcctcg 3545221 gaggccgggt tattcgtatg gttccttcat aatcgatgga agaatgttag acaatcgagc 3545281 tgaacaatca gttttgggat aaagtggtga atttctcatt tcttcggcgc tggctttcat 3545341 ctcccagtcg ccgactcata tccccctaaa aatgaaaaac cccgagtctt gtttcggctc 3545401 gggattttcc atgtcctatt tctgtatcac cagtttactc aatgtttacg aaaaatatct 3545461 caaatacttt aaaagttcac aaaaaattca taaattaatt gttttctgga agcaggctcg 3545521 tttttaactc atctgaggaa cggtcccata ggccctgatc atgctttttc agaaattcgc 3545581 ctagtacacg cttcgagctg tcgtccattt tatcaacgat gattttccgt ttcatggatt 3545641 tatccatcag attcacatgc tcaggcagtg acttgtagcc tcttctgatg cttctgtcga 3545701 ccgtcatttc acaggctgtc acaccagcgt aataaggccc ctcttctttt ctgtcaatcg 3545761 ttacccacac aagccagtat ggttttccgt tcggcacttc ttctttattc gggagaaatt 3545821 taattccttt ttcaacggtg ctgcgggcat gcatagcgcc gatgtctacg aacgcttctt 3545881 tttcctctac atcaacgaat acgggagaaa tgttatcaag gctgagtgcc cctacgccaa 3545941 aaccgccgtg tccgtctgtc ggatcacttt tgataatatt aaacccgatt gattttttct 3546001 ttttttcttc catgaagttc tacctcctac aaaagcggtt gaaatatcgc tgaaaacagc 3546061 tttaaaatcg aatctcttcc tgcattgagc atcggccaca gcacgtaaga tcctagcggt 3546121 gtcacaaaca gcaccaaaaa tacgataaag ccgtagctct ccgcctgcgt cattttggca 3546181 cgcacgcccg gcggaacgag atcttctata attcgatagc catcgagcgg aggaagcggc 3546241 agcagattaa ataaaaacaa gacaagattc agctgtatcc aaatagaaaa aaactgatcc 3546301 agccccgtgc tgaacgccgc aagcatttcc attccgtacg catgcatcaa cactaacaaa 3546361 aagaaaccaa taaacgcaag aatcaggtta ctgacgggcc cggctataga tacgagcaca 3546421 ccagcaagcc ggggtttctt aaagaaacgg cgattcacgg gaatggggcg cgcccacccg 3546481 aatccggcca ccagaatcaa aatggttccg aacggatcaa ggtgtttaat gggattcagc 3546541 gtcagtcttc cttgtttttt cgccgtatcg tcaccgaatt tgtatgcgac ataagcgtgg 3546601 gcaagctcgt gcatcgtaaa cgacacaatt agcgtgatga cgaggtatgg cattaaagat 3546661 aacggataat ataaaaaacg gtccaagtga gatatccctc tttctcaaaa tgcaagaatt 3546721 tactttattc agtatactat aagaagcctc tttttctaaa gagaggaaac gagataaagg 3546781 aggattcagc acccatgcca tacgtaactg tcaaaatgct cgaaggccgt acagacgagc 3546841 aaaaacgcaa tcttgtcgag aaagtaacag aagccgtaaa ggaaacaacc ggtgcttctg 3546901 aagaaaaaat tgttgtcttt atagaagaaa tgagaaaaga ccattatgcc gtcgcaggca 3546961 aacgcctgag cgatatggaa taatctctat aaagccggcg cttcgcgcac cggcttttat 3547021 tatccctatt gagccagctt cgcaataatc gccaagaacg tctttttctc ttcggctgtt 3547081 aaacgttcaa acatgccatc aatcagctgc tggcggtttt cgatcatttg ttcagccgct 3547141 ccccggcccg attcagaaag agtaatccat acagtgcggc ggtcattgtt atttctggat 3547201 ctctcaataa acccttcctg ctctaaatga ttcagagctg tggtcgtggc agagggagac 3547261 agtgtgacct ccttcaaaat atcctttatg gtgcagctcc catgtctgta tatgatccgc 3547321 agaataaacc ctcttacatt attcacgtgt ttcggaacgg tggcttcatc taattgcttc 3547381 gtgcttttca aatactttgt aagtgcgtga tccagcaaat ttgcttccag tttgtcatgg 3547441 tccatgtcaa tttccccatt tcgagatgca ttcataacat acgaacgata tgatttactt 3547501 attattttac tgattccgaa tagggaaagt caaaaaagca aaatgtgaat tcacagcttt 3547561 tatcctacat gcctcgattt tccacctgtt tcacaagttt atctttaaaa gtttggaaag 3547621 gaacgtgttc attctgctga tgtccgaatc ggcggacgtt taccgcattc tcctgctcct 3547681 catgatctcc aagcaccagc acgtacggaa ttttttgcac ctgcgattct ctgattttat 3547741 agccgagctt ctcattgcgc tcatcaatgc cggctcttat ccccgcctgc ttcagctccg 3547801 cctgcacttt tctgcaatag tctaagtgaa cgtgcgaaac cggtatgatt tgaacctgga 3547861 tcggtgcgag ccagactgga aaagccccac cgtaatgctc gatcaaaatg ccgaagaaac 3547921 ggtcgattga gccgaaaacc gctctgtgga tgacaacggg acgaaccttc tcattgagtt 3547981 cgttgatata tgttaaatca aatttttccg gcatttgaaa atcaagctga attgtcgcgc 3548041 attggtggct ccgtttcagg gcatctttta tatggaaatc aattttcggc ccgtaaaacg 3548101 ccccatcgcc ttcattgatc tcataagaga ggccaagctc ctcaaggacg cgtgctaagg 3548161 cacgttccga cgcttcccaa aggctgtcat cgcctaatga atcctccggg cgagtcgaaa 3548221 gctcaacaga atactcgaaa ccaaatgtcc gatatacctc atcaatcagc cgaatcgctt 3548281 ctttgatctc actctcaatc tgatcctccc gaacgaaaat atgggcgtca tcctgacaga 3548341 acgtccgaac gcgaagcatt ccgtttaaag cgccgctgta ttcatggcgg tgcacctgtc 3548401 cgaattccgc catgcgaatc ggcagatccc gataagaata caggctgttt ttaaagatga 3548461 gcatgtggcc ggggcaattc atcggcttca ttgcgaatct tgtatcatcc acttctgaaa 3548521 agtacatatt gtcgcgataa tggtcccaat ggcctgactg ctcccataac cgctgattca 3548581 tcataaacgg cgtacgcacc tcatcgtagc cggcatttgt ttgcagctca cgcgagaagc 3548641 gctccagctc attgcggaca atctgccctt tcggcaaata aaacggcatc cccggcgctt 3548701 cttcagaaaa cataaacagc cctaactgtt tgccgagctt gcgatggtct cgttttgccg 3548761 cttcttctag catatgcagg tgcgcatcca aatctttttt cttttgaaac gcaaccccgt 3548821 acacccgctg caggacttca tttttgctgt ctccgcgcca ataagcgcct gatactcttg 3548881 tcagtttgaa cgccttgatc atccctgtag aaggaagatg cggccctcgg cacaggtcaa 3548941 cgaattcccc ttgctggtac agtgtgatat cctccccgcg cggaatatcc tttaaaatct 3549001 caagcttgag ccgctcgtct ttttgtgcaa acagctcttc agcttcttcg taagaaacct 3549061 ctatacgttt gatttcaagg ttctcattta ttatgttttt catttctttt tcgatggcct 3549121 ctaagtctcc tgatgccaag cttttcccca gcttcatgtc atagtagaag ccgtctaaaa 3549181 tcacaggccc tacccccaat gacacttcgc cgtacagccg ttttactgct tgggccagca 3549241 cgtgcgctgt tgtgtggcga agcacctgca agccttcttg tgaatcgagt gtgacaatcg 3549301 aaagctcagc atcctcctcc agcttgaaac tgagatcaac aagcttgccg ttgacctgac 3549361 ctgcggccgc cttcttttgc agactggaac tgatcgaacc agccgcttct ttgattgtga 3549421 tgcctttcgg atattcctgg atctgtccgt ccggaagctg aatgtgtaca tgtttgctca 3549481 ttttagaaca ctccttattc attgttgtat ataaaaaaac acacccgtcc cgcagatagg 3549541 gacgagtgtg tgattaaccc gtggttccac ccaagttccc gacaaatact atgttgtcgg 3549601 ctcggtgctg taacgcagca tagacggcat tggttacttc agttccccaa tgctgctcca 3549661 aggcggtaaa tgatattcct aagctgggaa gctctcacct ttccttccct ctctgaaaac 3549721 cgtaactatc attcatgtcc ttttcatcgc atgtattcaa ttcataaaaa aacacacccg 3549781 tcccacagat agggacgagt gtgtgattaa cccgtggttc cacccaagtt cccgacaaat 3549841 actatgttgt cggctcggtg ctgtaacgca gcatagacgg cattggttac ttcagttccc 3549901 caatgctgct ccaaggcggt aaatgatatt cctaagctgg gaagctctca cctttccttc 3549961 cctctctgaa aaccgtaact atcattcatg tccttttctt cgcatgtatt caattcaaat 3550021 aaaaaaacac acccatccct ctaaaaggga cgaatgtgtt gatcatccgt ggttccaccc 3550081 aaattcccga tcaattacac atgatgatcg gcttaaagat gctgtaacgc agcatgacgg 3550141 tatcagatac ttgttttccc tgatacggct caaaggcggt aagctgcttt ccctgcgtta 3550201 ggaagatctc agctgtcctt ccctctctgg aaaccgtaaa aagcatctcg tgtccttatc 3550261 agtgcctgtt gtttcaataa ttttttatat cttactatat attcccacaa agcgcaatca 3550321 gtgatttaca ttttttctga cgcggcagtc ccgttatggg cagccagaaa cagccataca 3550381 agcaatgcag cgaggctgta tgccgctccc atcatcaaaa acgcaaaccc ggcaccagca 3550441 taccaagtgg cggacagatg aatgatcacc ccggttatcg ctacgccgac caaggctccg 3550501 atttgccggt ttgcatttaa cgccgcaccg gcgatattcg tatgtctttg cccggcagcc 3550561 tgcatgatca cagttgtcat ggcaggaact gtaataccgg tacagaggtt cataacagac 3550621 atcaacaccg ccagctgcca ataaggaaaa tccggagaaa tcagcacaaa caacagcaat 3550681 gcaatgatac agctgaccgc cattgataca aacataagct gaccggcttc aaaccgattc 3550741 gccagacggg caaacagcag attgccgatc acgaagaccg ccatcatcgg cagcagctcc 3550801 actccagcca taaaggaact tgcccctcct gcttcctgca aaaaaaggct gagcataaac 3550861 atgccgccaa aaagggcgaa attcagcaaa aacccgataa attgggcagc tgagaagcgg 3550921 ccgtttttgt ataaggacgc cggcaggatg ggtgtttttg cagaaatttc ccgcagcaaa 3550981 aacagcacaa atgccaaaac cgctgcagta aatgctacaa gaatcactgg cgagcgccag 3551041 cccgctgaag gcccctgtat caaagcatag gaaagaaacc cgagagccat catgccaagc 3551101 agatgcccga tgatgttcac gcggctgctt ttcccaggaa cgcggctgag gattcggtaa 3551161 gctgaaatga gcgcagcagc ccctattggc acattgatca gaaaaatact ctgccagccc 3551221 gccaactgta ccagcacgcc cccgataaaa ggcccaaggg ctgaagcggc ggaaacaagc 3551281 gcggcccaca gtccaaacat tctcgcccgc gcccgctcat caaggtaaga ggcagccaaa 3551341 aggctgagtg agcttggcat aaacaaagct gccccaattc cctgtatgag acgtccggca 3551401 atcagcatct gcccatttat agatgcagcg catagacagg aggccataac aaaaacggct 3551461 agacccaaga tatagatcgt cttcgagccg aaacggtcag ccaaggctcc gcccgccagc 3551521 agaagcgacg caaaagtaag aatgtacccg tccacaaccc acgttacacc tgaaagtgac 3551581 attgaaagag tgtttttcat atcagccatc gccacattca caacggtcac atcaagagtt 3551641 gccatgagga aaccaagtgc gagcacgatc agcacggata tgcctgttga tgatgttgat 3551701 tcttgtatag acccgctatt tttcattaca attgcccttt cacttgcttg attacccaat 3551761 catctatttt ttcaagatca tacaattccc cgactctgtc cataacatgc tgcaaggatt 3551821 cttctctcat aagattggac catttatcct cgatttccgc catgactgtc tccagcacac 3551881 agtgactttc accctcaaat acagattgca gcaagccttt cccctgatac atcgaacctc 3551941 tgccttcgac cgcttgataa acatcataaa gcgtaatgtc agccaaaggc ttcgtcaggg 3552001 taaaaccgcc cttcgtccct ggtaaggatt ctgccaaacc ggcttgaacc aatgttctca 3552061 tcagcttctt caagtaagac ggagacacgc gcaatcgctg gcttatagcc tctgacgtca 3552121 aagaagcctg taccggcagc cgtgacagta acagcagcac agaaaccgcc tgctccattc 3552181 ctgatttcat tttcatccta ttcactcctg attcattatg gataactatt atccataatg 3552241 aatctcttag cagcttttgt caataaaaaa agcaaaagaa acggatcatt tcttttgctt 3552301 ggtatggtta acaaatctgc ttcagttcct ctatgtattg aagcgcttcg tcatattctt 3552361 catttgtata tttttgcttg cttttgatgg taaagacttt ttctttcttt tcctcatcct 3552421 caagcccgtc aaagtaaagg atcgtggaaa ccagctctaa aaaccgtgat gaacggctgt 3552481 ttacactgtc gatatagcct ttcatatccg gcatgtccag atcagcatgg tctaaaaatg 3552541 cggagcctgt ctcagtcagc gaataccggt attgaaagta gccgcccttt ttttccttca 3552601 cctcatgcag aaatccaagg ttgcacagct cttcaatctg gagcgtcagt tcctctgaat 3552661 atggtccgta aaagtgaaaa tcatatttct catagaaagg aaactgcatt ttcttggcga 3552721 tataaatcat tttctgcagc ttctttcgcc cgatgatttc tccagaatcc gagaacacct 3552781 tcatcagttt tgcatgttct ttcaacaaat tcccgacatc tcctttttcc ttctttccaa 3552841 tttctatgtc agtcccagca gctgccggat tttcattttc gcttccggat gtttagtgcc 3552901 gtcacaaatc aagtcctttg gatagtacag cttgtggtcc gtccgccgtt tacctgagat 3552961 ggattccaca atagccgact gtctggacag ctctttaatt tggccgtttt gcgtcaagag 3553021 atggatcggc agacgctcct cttcctctcc tggtcggtaa aaatcgtatg gcagatctga 3553081 tgaagaatca acgaccaaat aatagctcgg atcgatcccc gcctctttga acaatgaagt 3553141 cagctcaaaa taagccgaca tttcttcatt cggattgaat tcaacgtatt ggaaaagctg 3553201 gcggttaatg aatctgcggc acaagtcgga taaaatcgcg tcttcttcat cctcccaggc 3553261 ctggaagtaa tacaaaataa tagattcatc cagctttaca taatcctcca gtgtcaattt 3553321 tccttcaaaa atagaataga aatgaaccgg agcgtgagtg aagacatagc cttcatcgtg 3553381 cagctgcttc gccctgtgaa gaatcttcgt taaaatgacc tctgcacttc tagtcacagg 3553441 atggaagtag acctgccagt acatttggta acggctcatg atatagtctt cgacagcgtg 3553501 cattccgctt tctttaatga cgatctgatc ctcgcgcggc cgcatcaccc gaagaatccg 3553561 ctccatatca aaatggccgt agctgacgcc cgtataatat gcgtcgcgct ggaggtaatc 3553621 catgcggtct gcgtcaatct gactcgaaat caggctgacc acttgcttgt ttttatatgt 3553681 tttggcaatg acttcagcaa catcctgagg gaaacccggg ctcacctttc tgagcacctg 3553741 attaacctcc gtgtctccca aaatgatacc tcttgtaaaa tcctcgtggt caaggtgaaa 3553801 gaccttttca aatgaatgcg agaacggccc gtgcccgagg tcatgaagca gcgccgcggc 3553861 caaacagagt tcgcgctcac tgtcatccca ttcagggcgg cctttaaaga cgtcatcaac 3553921 cattcttctg acaatttcat agacaccgag agaatggttg aaccggctgt gctcagcccc 3553981 atggaacgtc aaataggtcg ttccgagctg cttaattctg cggagacgct gaaattcacg 3554041 ggttccgatc aaatcccata tcagcttgtc ccgaacatga acatagcggt gcaccggatc 3554101 tttaaacact ttttcttctg ataattttcc atttggatac gccatcgtca ttccctcttt 3554161 tttttagccg tgtttctatt atatcgactc tattctttga aaacatcctt gaatttgccc 3554221 ggcgatttgt tccatcttca tgaaaaacac atcttgtgaa gcaaaaaagc ctgacctgag 3554281 ggccgaggct aagaaaaaat atgtttttac ttttttattt tcttttttac tttgtcaatc 3554341 agctcatcct ctgtcggagc tgacagcggg cgattgttca caaaagcaaa tgattttttc 3554401 cgtccgggcc cgcaataaga ttggcatcct acctcaacct ttgcgtccgg gtccacttct 3554461 ttcaaacgcg gcagcaatgt tttgatatta gtggcttggc aatcatcaca cactcgaaat 3554521 tcattagcca tgacgtacgc ttcccttcat ttctatgttc atctatgtga ataacctaaa 3554581 atcacgtttc aaaaaaaatc acatcacact tcattttaca aggattcgac tgttcctgca 3554641 agccgctcca tccttcgtat ctcctattct ttcagccaat ttgtataaat attttccaac 3554701 ctggacattc taataccatg aaaagaaaaa tgggagttga gataaatgac aaaacagcga 3554761 caagacgctt ggtcagagga aaacgatctg cttttagccg aaacagtgct tcggcatgtg 3554821 agggagggca gcactcagct gaacgccttt gaagaagtcg gcgataaatt aaaccggaca 3554881 tccgcagcct gcggattcag atggaacgca gtggtccgcc atcaatatga aaaagcgctt 3554941 cagcttgcga agaaacaacg aaaacagcgg atgagagcgc tcggaaacgg gcagcccgcg 3555001 aaaaaaagat tattatatca gcctcctgcc gttgatcctg aaatcattca agaaaccgct 3555061 gcagaagagc cggttaaaac ggaaacacca tctgtcgaaa atgagcaacc tttaatgtct 3555121 ggcgaacaca tgccttttgt tgatgaaagc tttaaggaag agttagctag tctatcacac 3555181 ttattgtctc ctcaaacgcc tgcagctgcg cctgagatga cgatgaatga tgtgatccgc 3555241 ttcctgcaga attacgaagg caatcacgag caatcatcag cattaaaaat ggaaaacgag 3555301 cgtttaaaga aagaaaatca ggaattgcaa aacaaaacag agcagctaga ggcagaagtt 3555361 caaaagcttg aaaaagacca aaaaacgatc caagaagatt atgaaacctt ggtgaaaatt 3555421 atgaacagag ccagaaagct agttttattt gaagaagatg aacatgcctc tccgtccttc 3555481 aaaatggacc ggaacggcaa tttagaaaaa ttagcggaat gacatagaaa aatcccaaaa 3555541 cgggcagctg ttttgggatt ttcgccatgt gcaaaatccc cttttctatt gagaaaagag 3555601 aatttcctca ttttgcagcc ggatcagcta ttcttgtaaa atgaggccaa gcttatgtga 3555661 atctattaag acatgtgagc tgcctcggcc gttttttgtt tccgaggcgc agcagaaatg 3555721 accaaaagcc ccagcatcat aagcgcaatg cccagccacg aggaaggcga aagcatttcc 3555781 cctatgaaaa acacgccaag caatgaagcc gtcagcggtt cagctaaaga cagcgtgacc 3555841 gccgccgagg ccggaacccc ggtaagccct ttcgcaaaca aaaagtatgc ggcacatgtt 3555901 gcaattaacc cgatgtaaag gcttgttccc agtcctctag gggtcaatat ccacgagata 3555961 tctaactgcc ataatagcgg cgtcagcaag atggcgctga tcatgaatac aacggcggag 3556021 gtcgctcgcg gaggctgggt tttcatcatc gctttactga tgagcgtata gcctgcaaaa 3556081 gaagcacccg ctccaagcgc cataagaaca ccagccacat caatccgaac attggaactg 3556141 tcggaaaaca gaagccagca acccgctaaa gccagcacag tcgcaatcca ccaggagttt 3556201 cgcgggcgtt tcttcaatac agcccattcg agggtcccgg caatgatagg cgcactgccg 3556261 atggcaatca cagttcccac tgcaattccc gtttctttaa ccgctgtgaa aaacagcggc 3556321 tggtaacacg ccatacaaac agcggctaaa aatacgagcg gccatgccca atttttcacg 3556381 tgaagctccc ggctgatcca aaccgcaagc agcatggcgc ttcctcctat taataacctg 3556441 aacgctccaa atgccagcgg tgtggcgctt tctggagcca atgcctgaac ggttcccgtg 3556501 gtcccccaga aaaaagccgc aatcaataca aaaaggctgt aaatattccc cttcatctgc 3556561 ctctcccctt taatatggat gctgatgtca ttttatcgtt tttctttttg tcgtggttat 3556621 ctgtatgtaa gaaggactta tctgaaaata agattattga ggtaaaatgc cgcttgagat 3556681 aaaaaatgca tgccggcata tacagccggc atgcgaagaa cgttcaccca aatacctttg 3556741 cattccgctc agccatccgg acgaggtttt tctcaaattc catttcctca tcaatggaca 3556801 gtccagctga ataaagatgg gtgcttaacg cttttaattc cgtcaataaa gcgaacatta 3556861 agtcttgtac ggagatgtct ttttgaagaa gctcacttaa ggacgccatc gtttccggac 3556921 gtatttccgg atagacgcct tttttatcgt tttgtttgtc tttcagcgcc gcttgataga 3556981 atcgtctgat caagtcggcc ctttcactgc cgcttttatc tgcacagaga taaatttgaa 3557041 cagcgactcc gccgcgaacg cgtctctgag agatgccggc gaactttttg ccatttatac 3557101 tgaggtcata gctgccggga caataagacc cttcaatttc ataggcttcg atctttgcgt 3557161 tgtacggtct cagcattcgt ctcatcagct cgaccatcgc ttcatatcct ttgtctatat 3557221 cgatgccttt cttttcgtcc tcgaatatga gagagatatt taaaacaccg tcatccaata 3557281 cgacggcaag accgccggaa ttgcgtacga tcacacggta tccttcgctc tccagcaagg 3557341 agataccatc ctgcaaaaac gggaggcgtg tatcctgtat tccaaggaca attgtatcgt 3557401 ggtgcaccca tgagcgcgct gtcgccggcg acacgccttt tccgacggac atgcatagcg 3557461 tatcatccat tgcgaaggat tgcttcgcat caaataaagg gccgagactg gattggtcaa 3557521 tgactctcca tttcggctgc atcagtaaat caatcggttg gtttgccatc tatgtaaaac 3557581 cctttcatgt taggcttatt gaacgaaaac tattatatca tttcagcagc tgtgattgat 3557641 aattgctttt cagcatcgta ataaaaattt ctttattttt tgtattctcc atgagaggag 3557701 aatgaatgta agacagcttg cgctttaacg agaaattatt aatatgcaga attgaaattt 3557761 cgcggtggat caaatcctta cgcagcacgc ttctggatag aaccgaaagt cccatgccgt 3557821 taatcaccgc ttcctttaca ccttgattgc tgctgatggt aaacattgat ttcggccgaa 3557881 gtccatttga actgagtaca tgatcgagat attctctcgt cccggagcct ttctctcttg 3557941 tcacccacgc ttcgttctgc aaatcgctga tcgaaatctc tttccgcccg gcgagcggat 3558001 gctgatttgg agcggcaatg cacatttcat cctccatgaa cggttcaatt tccagctcat 3558061 tctcgtttgt atgtccttca atcagcccga tatcagcctg aagcatccgc acacgctcgc 3558121 tgacctcctc tgtattgcca atcatgacat ctagattcag ctctggatac agcttttgca 3558181 gctgggccaa tagcggcgga agaatatact caccgattgt aaagcttgca gctattttca 3558241 attcaccctt cacatagtga tgatgcgcat agatttcagc cttggcttgt tcgtagagaa 3558301 acaccatttg ctttgctctt tgatataaaa tgtctcctgt cggcgttgtc gtaaagtgtt 3558361 ttggcgacct gttcagaaga gccgtttgaa attctttctc aagatttttg atatgcagac 3558421 tgacgctggg ctgggagatc atcagctttt ccgccgcttt tgtgaagttt ttttcttcta 3558481 ccaccgctat aaacgttttc agcacgtcgt aatacaaaaa ccccacccct gtcattaatg 3558541 aaatatatgg ttatgattag ttttctttat tgtactcata tcatccgtct tggtaaagaa 3558601 gggctataca gaagcgcaaa aaaggcagcc ctcggtcgag agctgccatt gtcttcaatt 3558661 ttattacagt gcttgcgccg ctgtaattaa tgcgagattg taaacatctt cagcgttaca 3558721 tcctcttgaa aggtcgttta caggcatatt taaaccttgc aggattggtc ctaccgcttc 3558781 aaagttgccc aaacgctgag cgattttata gccgatgttt cctgcttcaa gacttgggaa 3558841 tacgaatacg ttagcgtccc ctttgatctc ggaatccggc gcttttttct cagctacaga 3558901 tggaacaaat gcagcatcaa attggaattc gccgtcaagt gtcagttcag gcgctttttc 3558961 tttcgcgatt ttcactgcat ccgctacttt ttctgtttca tcagattttg ctgagccttt 3559021 tgtagagaag ctgagcattg ccacgcgagg ctcaatgtcg aacatttttg ccgtattggc 3559081 actttcgatc gcaatctcgg caagatcttg gctgtcaggt gcaatgttga tcgcgcaatc 3559141 tgcgaatacg tattgctctt ctccgcgagc catgatgaac acgcctgaag tctttttcac 3559201 gccttctttt gttttgatga tttgaagagc cgggcggaca gtgtcagcag ttgagtgagc 3559261 agctccgctt acaagtccgt ctgcaagtcc tttatacacc agcattgtac cgaagtagtt 3559321 ctcgtctaat aatgctttac gagcctgttc ttcagtcgct ttgcctttgc ggcgttctac 3559381 gaatgcttgt acaaggtctt ccatgccttc atatgtatga ggatcataaa tcttaacgcc 3559441 gcccagcgta aggttcaatt cttttgcttt tgcttggatc tcattttcat tgccgatcac 3559501 aatcggattc agcactttgt ttcctgcaag cttgctgacc gcttctaaaa tacgctcgtc 3559561 taagccttca ggaaatacaa ttttaacgtc ttttccagct actttttctt gcactgttga 3559621 aaataaatct gccacaataa aacctcctca aaaagttaca aaaacgcttt cttttactag 3559681 catactcttc ttccaatcaa attcaaacag ccaactttca ttatagcgct ttcataaaaa 3559741 aatcttattt ttctaactaa tttaagtgac tcaatcttcc cttataggtt cttctatttt 3559801 gatggagtta tacggaaggg atgttcaagg tttctccaca gtagaatcgg ataaactatg 3559861 gtatagtgaa ggcaatcatg aaaagataat gggagtgaag ataaatgagt gaacagcaaa 3559921 tgacgaatga agcggcaaaa acgcttgacg gctggtatgc gcttcatgat ttccgcacaa 3559981 tggattgggc ttcctggaag cttctgtcca gtgatgagcg ccaatctatc atacatgaat 3560041 tcaccgggtt gcttgaaaaa tggggcgtag cccaaaaaga aggaaaagga tcgcaaactc 3560101 tttacagcat cgtcggccaa aaagctgatt ttatgctgat gatccttcgt cctacaatgg 3560161 aagaattaaa tcaaattgag cttgaattca acaaatcaag acttgctgag ttcaccattc 3560221 cggcatactc ctacgtatca gtggtagagc tgagcaacta cttggcaagc ggtgacggcg 3560281 atccttatga aaatccgcat gtgcgcgctc gcctttaccc tgaactgccg gaatctaaat 3560341 atgtatgctt ctatccaatg gataaaagaa gatctggcaa cgacaactgg tatatgcttt 3560401 caatggaaga acgcagaaac ttgatgagaa gccacggttt aatcggccgc agctatgcgg 3560461 gcaaagtcaa acagatcatc accggctctg tcggctttga cgattacgag tggggcgtta 3560521 cattatttag cgatgatgtc cttcaattca agaagctagt gtacgaaatg cgttttgacg 3560581 aagtcagcgc tcgctatggc gaatttggtt cattctttgt cggcaatcac ctttcgcttg 3560641 atacacttcc tcaattctta tatgtataat atcccctccc gccctatccg gcgggagttt 3560701 ttcaattctc ctttatcaga atttaaataa aatttgctat tttcttcgtt ttttcttacg 3560761 atgtagataa taatccattt ttttcaaagg ggtgcagtta tttgtcaaaa cgaaccgcat 3560821 ttgttatggg agccagtcaa gggatcggga aagcaatcgc tctgaaatta gcagaccagc 3560881 acttttccct cgtcattaat tcgcgaaatt tggataatat tgaatctgtc aaagaagaca 3560941 ttttggccaa gcatcctgag gcgagcgtca ttgtccttgc gggcgatatg tctgaccagc 3561001 atacgagagc gggcattttt cagaaaatcg aatctcaatg cggacggctt gatgttctga 3561061 ttaataatat cccgggcggc gcgcctgaca catttgataa ctgcaatata gaggatatga 3561121 cggccacgtt cactcaaaag accgttgcct atattgacgc aatcaagcgt gcttcctcac 3561181 tgatgaaaca aaacgagttt ggcagaatca tcaacattgt cggaaatctg tggaaagaac 3561241 ccggcgccaa catgttcaca aacagtatga tgaatgccgc tttaattaac gccagtaaaa 3561301 atatttccat ccagcttgct cctcacaaca ttactgtcaa ctgtctgaat cctggtttta 3561361 tcgctacaga ccgttatcat caatttgtgg aaaatgtgat gaaaaagaac agcatatcca 3561421 aacagaaagc agaagaacag attgcttccg ggattccgat gaaacgggtc ggatcagccg 3561481 aagaaaccgc agcgctcgcc gcatttcttg cctctgagga agcctcctac atcacgggac 3561541 agcaaatttc cgctgacggc ggcagcatga aaagcatata aaaacatccc gctttttagc 3561601 gggatgtttc ttgtaatgac ccgaacggca ggttcagctt ttgaatccgc gtgacaaatt 3561661 cccgcagatc ctcctgcttc gacaccattg agattctgac atgccttttt ccgttgcttc 3561721 caaaaatttc gcccggtgtg actacgacat gggcatgctc cagcaagtaa tcggaaaatt 3561781 ggtgagatgt ctcaaacgta ttcggaattt cagcccatac gtaaaaggtt ccttttggct 3561841 tttccatctt ccagcccagt tccttttcac aaagcgccgt aaaaaagtca attcgttcct 3561901 tataaattcg tttcaacgat tccgtatgct ccggatctcc agaaagcgcc gcactcgctg 3561961 cctgctgcag cccgccgaac atgccgacaa atacatgatc ctgaaattca ttgacggcct 3562021 gaatgatttt ttcgttccca accgcaaacg ccattctcca gccggccatg ttaaatgttt 3562081 ttgaaaatga ataaagctct gctccgacag ttttggcatc ctctgcctca agaaagctgg 3562141 ccggtttttg atcgaattca aacgccccgt atgcaaaatc atgaatcaaa tggatgttat 3562201 gctctttcgc aaaagcagca gcttttgcat aaaaagccgc atcagccaca gctccagtgg 3562261 ggttgttcgg atagtttaaa aacataagct tcgctttttc cagcacggct ggatcaatct 3562321 tttcaaaatc cggcagatag ccattttctt catacagcgg catttcgtaa agctcagctc 3562381 gcgccatcgt aatccctgat aaatattcag gatagcctgg attcgggact aaagcgatgt 3562441 ctcccggatt gagcaggcat tgtgtcagca catacaatcc ggctttcccg cctccgaaaa 3562501 gcgcgacttc cgtttcagga ttgattgtca ctccgtattc ccttttatag aaagcggcga 3562561 tcgcttcctt taaaaaagga tagcccctga aagggccgta tccatgaaac gaaggattca 3562621 gagaagcctc ccgcaaagcc tcgacaatat gcggcggagt gggaaggtca gggttcccct 3562681 gtccgagatt aatgatatgg gctcccgttt tttccatttc ctttaccttt tgaaaaacga 3562741 gagaaaactc ctgccttgga agtgtcttga tgacatcgga cggtgttatt tccatctaaa 3562801 agactccttt ttgctccgtt ttgttatccc gttccaaaaa cgatttgttg acgagcttcg 3562861 tatgcaaaaa caaaccgcat acgatcacga caatcagccc cataatgacc ggagcgctta 3562921 ggatgttaat gaacattgaa ccaatagaaa tgcataatcc gatagacgct tcggccactg 3562981 aaaaaatgcg cccttgaatc tggtttgccg cattttcctg aaccttcact tttgcaagca 3563041 cttccccgta ttccatcgcg atgaaaaaga ggatcgccgc gatgacagaa acagcgaata 3563101 tcggtgtgaa taaaaacagc gccagcgaga caatggataa aacggtaaag tacgtcaggc 3563161 ctctattgtt gttaaagccc catttgctga caagcgccgc tccgataaag ccgccgaagc 3563221 cgatgcagaa cgtgagaata aagttgccga tttccccgtc acccagaaag cggctgacaa 3563281 tcggaaaata gctgtacaca actccccaca gcaaagccat tgtaatcatc gtaaacatgg 3563341 cgtttaatac gaatgaattg gttttgattt ccttgagtcc ttccttaaaa gactgaaagg 3563401 cctctttaat gttttcagat tgaatcggca caaattgcag cttgatgcgg ctgataaaaa 3563461 atgccgaaac caagtatgtc acaccgttaa aggcaacagc cagctctaca gatccgccta 3563521 acagaaagag ccctccggca gccgccccga cgataatgga gatggttgtc gcttttgcaa 3563581 ataacgtgtt gatgctttta atatctgatt ccaaggacga catgacagcg agacgggcgg 3563641 gattaaaaaa cacgccgctt ccataagtaa taaacagcag ggccagaaaa atcagcggat 3563701 actcgccttt tggaagaaat gtgagcccca aaaagatgat gcctctgatg atatccgtcc 3563761 acagcatgat cttaattctg tctaaccggt cgaccagaac acccaaaaac ggctgaaaca 3563821 ccatcggaat gcttctgacc acgatgaccc cggacgtcac ccaataatcg tgataatatg 3563881 tagacaaaat gagcagggca gggagaacac aatagtctcc catgaacgat agcgcctgcc 3563941 cgtaaagcaa gtatttagag ttgggtttca gctgtttcat actggcagca catactttgc 3564001 cgtcagcttc gcatgctgct gaatttgtct gattgattca gccacatcct gtgaattact 3564061 gcctttcagt tcaaatgcag caatggaatt gaaagcttca aacaatgtca aatcaactga 3564121 agtgcctggt gctgcggccg aaaaagaaac gatttcagta tcccctttta aaagcccgtc 3564181 cggaatatcg atcgcttcaa tgaccaaatc ctcagcagtt tcaggaattt ggccattttg 3564241 tttgaaatgc tgcgggtaca aatggcagtc ggcaacataa taaggctctt gatccaataa 3564301 tccgtccggc agatcggcgt cttttccgaa acagaggaca tctaataata attgcgccat 3564361 atcaaggcca aagacctttt taatattggg gatcatattc cagccggcaa atctggctgc 3564421 cgactctatt aaacccggtt ctctgttttt cattagcttg atctctgtat gtgttgcgca 3564481 attttgcagt ccaagccctt catttgcctt tttggcagct tcgacaattt tcttttttgc 3564541 ctcttcatcc agaatggacg gcgtaatgtg ggatgtctct gtaaacccga tttgcggcgt 3564601 tttatcatga atggcgatcg ggaaatactc accgtcagcc atgatgcctt ctatactgat 3564661 atagtcggag tacccttctg tttgatacca gtctccgtac tcaccctgta aaaattcttc 3564721 agcgataaac ggcgcttcaa acgtaaccgc ctttggcacg ttaattgatt tcagatagtc 3564781 attgactctg ttaaattcat cttctgccgt ctcagtgtcc gtaatcagcg ttacaccgat 3564841 agaactcgct aagtatgtag gctttaagat aagaggtgtg ccgatctctt caagagcagc 3564901 acggaaatct tcaagagttg tgactcgttt gtttttgatc gatttgactc cggccttatt 3564961 aaaagcgtcc ctcattttat ttttatctct ggcattttcg gctgcctgca cgccggcacc 3565021 tctcaagccc agacgttcac aggctttcgc catcggagca atgaataatt cattgtttgt 3565081 tgtgatggca tccgccccaa acatttcggc aaccttgacg atttgctcga cgacctcttc 3565141 ctcaggcttg ttatgatctt catgcgccca ataaatggaa tcagggtgtt caaaatcagc 3565201 taaactctta aaatagtctt tatcttttat gaccgcgacc gagtattttt caatcaatgc 3565261 tgcatgggag gctgtaattg caaaaggtct tggaataaag ctgaccaggt tatatttttc 3565321 agcagcgctt ttataaaaca tgtgcggcgg gcagcctcca agatcagcga tgaccaatac 3565381 tgtttttctc tccatatgta aaacactcct tctctattgt gcggtgtatc ctccgtctgc 3565441 ggtgatggcg cttccggtca tatagcttga taaatccgag gctaaaaaca gcatcacatt 3565501 tgcgatttct tcaggtttcc caagcctcag cagcggattt accttcgctt tttctttttt 3565561 aatctcttca agtgtgcctt cattattttc aaggaatgat ttttcattca gcggtgtgtc 3565621 gatgatcccc gggcatacgc agttcacccg aatttgatgt ttcgcataat caacggccat 3565681 tgatttagtc agctgcaaaa ccccgccttt gctggcgtta taagcaggaa tatcaggcca 3565741 tgccacgagt ccgccgacag agcacgtatt aatgatgttg cccttgccgg cggccagcat 3565801 atgcttgagt gcatgtttgc tcattaaaaa catgccggtc aaattgactt gcagcacctt 3565861 gttccaatcg ctgagctcca tctcgtgaat aggcgccacg atttcgatgc ctgcattatt 3565921 aatcaagaca tcgagcccgc caaatgtatg aaccgccgat tcaactgcgt gctggcaggc 3565981 agcttcgtct gtgatgtccg tttgcacaaa gtgcagcctg tcattatttt cttttcgtac 3566041 cattgcttct ccttgcgctt catcaatatc cgccacaacc acattggcct gctggcccaa 3566101 aaaagcctga accgcagcat aaccaatgcc tgatgcgcct cctgtgatga ggacggtttt 3566161 atcggtgagg ttcatgatca ttcatccgcc ttcatttttt ttgcttttgc cctgttatag 3566221 cgcggcggga agaagatatt aatcgatttt gattcttttt ctgaacggtt gatggcacca 3566281 tgatcttcgc gaggctcaca gaaataggct gtgccgaatt tcatctcgac tgtgcagcct 3566341 tcgaccgtca tgtcatagcc gccgccgatg cagatgccta tttgttcatt ccgatgttta 3566401 tggaaaggca tttctccgcc atttccaggg attttggcaa gcataatttc tacccaatcc 3566461 tcaacaaaga acgtgacttc catgcccggc agcaggtctc ttgttttgaa aatatccaaa 3566521 aagtagtcct caggacttgt atatgtttca tcagctttca gccgcttgat atcaatagca 3566581 atcacttctt ggtctgtgtc gtttcttgcc ccgtgaggca catgcggcgg cgcgatatag 3566641 gcagattcca aggctgtcat ttttcttgtc acatctccga cagtcatcat cagctcgcca 3566701 gaaacgacca tgccgatttg gacctcctta tgctgatggg gttcaacatt ggtatgcggc 3566761 gggacgtaag acattaatac ttcagtatcc cctcgtacgg ttgaatactg cctcactccg 3566821 ttttcccatt caattaattt cggtgtcggg aaataaagct cctgcatatc ttctttagtt 3566881 ttcatcatca acgtctcctt ttccaaataa tgaccagctc attggaatgc ttttgaatgt 3566941 ttttacaaag gttagcccgt acttttgccg tgcaagctca ttggttaagg caatgtcata 3567001 caaaccttct tttacttttc ttgcggcttg actggttgaa ttgactagtt tgaaacgaac 3567061 atctttgcgg gtaaaatatt ttattaaatt aataggtgaa ggatgtgaaa caataacaga 3567121 tgtatcaagc atatcgtctc tgaattcaaa atcaggacga acagccaggc cgtacatcgg 3567181 tgtatcgcac ctgaagatct gcaatagctg caaatccggc ctcatgtaga aatgcttaat 3567241 gccatcgtaa gcatgtggga cgatggtata ttccagcggg ctttggagcg tcctttcgat 3567301 gcacgattca aaagtatcat gcaaggacaa tttactgttc agcccttgta gaagagtaaa 3567361 attggaaatg aaatgctttg ctgcgtactc actgcttgtc ccctcagggc cgagcgtgtt 3567421 gactgtaatg agtttggata gtgaatcagt tctttttttt gtctgaatgc tattatccaa 3567481 tataatcatg agcaccaacc aatcttttaa aattttaagt aaattttatc cagtggaaat 3567541 tgaactgtca atgttttttg aaaatattga taattattcc catacaaaca aaaaaaccct 3567601 ttaaaaaggg tttttaatta taggaattta gaaactttgt ttattgagat aaggactgat 3567661 cggccttctg ctcaagtttg ccgtactttt tatatgcgaa tacactgagc acaaatccga 3567721 ggactgtgat ggcggcgcaa atcaatccga cagctgcata gccgtatgcc acatatacgg 3567781 gtcccattaa agcagaacct aatgtcacgg ccagattcga ggcgagactg taaaacacca 3567841 tgacttttcc tcgatgacgc tctgagcagt cactcaaaat ggtgctgagc agcgtcaccg 3567901 tcaaactttg cattaatccc caaataaata ggctggcgat taacagaaac atagacgccg 3567961 gcgcatatgg taaacacgcc agcagaacgc tgatgacccc cagcgcaatc aaaagggagc 3568021 gcatttttcc gatgcggtcg gctatctttc ctgtaatcac actcatggaa aacccgattc 3568081 cataaatcat gataaataag cccgcagccg tgtttcctcc ggtaaaaacg tcctgaagat 3568141 aggtgcctaa aaaggaatac ataccgtaaa aaccaatcat attacaaaag gttattgtga 3568201 tataaacagg tacacgaggg actttcagcg catcccggaa tgttcctgcg ggctcttcta 3568261 tttcttcctt gccgctgttt ttatgttggg catggcggcg catttcaagg agaatcagca 3568321 gaacaactaa aacacccatc agggcgaaaa tccaaaacgt ccatctccaa tgcaggacgc 3568381 cgccgataaa tgatccgagc ggcactccga aaatcagcgc cagcgaccag cttgaaacga 3568441 tcagtcccat caccttgccc cggtatgtat aaggaacacg atcaccgaca actgcgtaag 3568501 cggtcggaac aaacgctccc gcagccaatc ccgaaagcgc ccggcctaaa aagaagaaaa 3568561 aaatattttg agctaaagcg catatcaccg ttcctatgat aaaaatcata agcccggcca 3568621 ataagctcag ttctctggag tatttatcgc ctaatggaac caaaagcggc gcaccgataa 3568681 aaatcataac gccgtaaata ctgatagata acgcaaggac gctgacatct gagctgaagg 3568741 cttttgctaa atccggcagc agcggtgaga tcacaagctc ttcagatccg gctgcaaata 3568801 cccccatcgt taaagccagt gccaacaata acggaaaatg atgttttgtt ttgatgtcat 3568861 tgttttgatt gctgttcatt ctttctcaaa cacctcttcc ataatcttct tatcataaag 3568921 ttgtattata gtttagcatt gttttttctc tatttacaat tcgaacgaaa tatttataag 3568981 ttttattatt ttcatttaaa tcccattata tatttctata tttcattcta aaaatacatg 3569041 aggatgtaac acgtaaaaaa agctctccgg cctcccggag agctttttct attgcgcctc 3569101 tgtctgcttt ttttcaatcg tttcatgatt tatacgcttt ttgatgctta gatgatagta 3569161 tgcataacag aaaataatga tcggcacacc gcagtataag ccaattcttt gatccggaat 3569221 gaaaataagg ctgatcaaca cgcagccata taaacaaaat ccgagaatcg ggactagcgg 3569281 ataaagcggc gttctgaact ccagatcatt cacatttccg ccttctgcca ggaaacgcct 3569341 gcgaaagaaa aattgcgacg cacaaatgga catccacgcg acaactgtca ccatgcccga 3569401 gattgagata caccataaat acactgtttc tgcagccatg acacttgtca gcagcgaaca 3569461 gcctgaaatg cctagcgtaa tcagcagggc attcatcggc acgccttttt ttgtcagtct 3569521 ggtgagaaag gagggaccca tttgatttga tgaaagtgac cacatcatac gcgacgccgc 3569581 atacaatccc gaattagcaa cagataaaat ggccgttaag atgacaaagt tcatgatatc 3569641 tgccgaaaat gggatgccga tttgatcgag tactgctaca aacgggcttt caatcacccc 3569701 cgccgttttg tacggaagga tggcaaccaa gacgaacata gcgagcacaa agaaaaacag 3569761 cgtgcgccaa ataacatttc gaatggactt tggcagtgtt ttttccgggc tttcactttc 3569821 ccctgccgca atgccgacaa gctccgttcc ctggaacgag aagtttacca tgaccagcgt 3569881 aaacataacg gccagcaccc cattagggaa aagccctcta tcagtcataa agttagacaa 3569941 aaagggtgtc tcctgtccgc ctttaaagtc aatcaagcca aacacagcgg ctccgccaat 3570001 cacaataaat aatatgatcg ccgccacttt gatgcttgaa aaccaaaatt ccatttccgc 3570061 aaagcttctg acagagagcg cattaatcaa aaagatgacg atgccgaaca cgaggcacca 3570121 tatccagatc ggaacggagg gcagccacct ttgcatcaaa atgcctgctg acgtcagctc 3570181 taaccctact gtattggccc agctgaacca atacagccag ccaatcataa agcctgtcga 3570241 ctgtcccaga aatttagtgg cgtaggcctg aaacgatccg gccaccggca tggcaacagc 3570301 caattctcct aaacaaagca tgacgagata cattaaaaat ccgccgatga tatacgcggc 3570361 aatggcgccg agcggtcccg cctggctaat ggtaaagcca gagcctagaa acagcccagt 3570421 gccaatcacc cctcccaaag caatcataaa caaatgcctg cttttcatgc tgcgctgcaa 3570481 ttcattttta tgattctgca tcatccttcc ccctttggtt cttttgccgt gatggtcatc 3570541 cggtagcttt gcaaaagatg aacggtggtt tgctgtatga ggagaggcaa tacatgaaat 3570601 gtgtacggtt tatagactcg ttctgtccat ttatggccgt cttttccgta cacgcccata 3570661 ttaatggatg gaatattcag cttgcgtatg tctttgaacg gaatggtccc aatcatattc 3570721 cacccaggga agttcctgat aaaagaatca atttcgccat cggtttcgtg cagtgataaa 3570781 aaactgccgt ctgccaagta ggggaaaaac tttttgaaga caaatgtttc gcctgtcgat 3570841 tcagcggttt tgtcagccgc ttctttaatc acatgctgca aaagctgatc tcttgcgcta 3570901 tcttctttca aatagttatg cggcaggtaa ggaggtgcgt aaaatagaat gacttttgcg 3570961 ccttgatcgg ggtcaagctt ttgaagctct tcgattgcct gaaagcatct catgcgaagt 3571021 tcaaggtgct cgttggcttt gaatgtctgc tcgatacact gctcgggatc tattccccgg 3571081 tttctcagct tttctaagta ttgctccagg ctatacactt gaatgcccca tgataaatgt 3571141 ttctttggca ggttggctct ttttacatat tcttcgtaat aatctgataa tttttgttct 3571201 gtctcccggc atgcttcctc agtgacttca ataagcaaat ccatcatttc ttttgctgtt 3571261 ctttcataaa taaaacaatt gaaatacaag ctggtgctga cagccgtttg cacattatag 3571321 gattccttgt tatcacgctg atacaaacag gatgggggca gaaccaactc cccttcaacc 3571381 ttttctgcca gatggatgtt attgtggaga cggcttgtga tttcagatga aatgaaattt 3571441 gggtcaatcc ctgccagtgt atcgccaaca tggacttcac gcccgtaaat gtaaaagcaa 3571501 ggcaacagtt ttcccgcggc tccggtatag atatatcttg tctgatcacc atcgtaaagc 3571561 ggggtaataa aatccgtatt aatagcagcc aaatagtgaa gctgtttttc tttttttagc 3571621 cggttcagct ctgaaatgct ggcgagaatg cccgaatgct ggctctcctc atcgggattg 3571681 gccataaaca atacatttcc cggcaacgtc tcaaggttct ccgaaaaatg caggagattg 3571741 gctaaatgca cggcgatgcc gctttgcata tcgacagatc ctcttccgaa catccactcg 3571801 cctgatttgg catcccgctg aacatcctga tcgaactcat agcggctgaa atactcggcc 3571861 aatttctcac aatcaaaagc gatatccttt aaagggccga aatcttcaat tccaactgta 3571921 tccagatggg catggtaaat gactgtattt cggctttctc catgtccttt aataaacgca 3571981 aaaatatttt tgcgtttgta tgggtcattg ggaatggcct gttcccacac atgactgggg 3572041 ttttcctgaa aataaggata gctcgtgatc acttctttga tgaaatctgc ttttgtccct 3572101 tctccaacgg tgccgttcac gctgctgagg ctgaccagag atgctgtcag cgcctccact 3572161 ctttcagccg gattcatgtg actgattttt gtatactgca taaattgtcc tcctgatcaa 3572221 aaagttgaaa tcgtgcgatc cgctaaagaa tcgcacgatt ttatttctct caaatcaaaa 3572281 agcttcggac gttgttttgg cttgcatatg aagaattaag taatcgggac cgcctgcttt 3572341 tgagtctgtt cctgacatat taaaaccgcc gaacggctga tagccgacaa ttgctccggt 3572401 acatcctctg ttaaaatata ggtttccgac atggaaatcc tcgcgcgccc gttcaatgtg 3572461 cgcacggttt ttcgtcagaa gcgcacctgt taatccgtat tccgtgttat tggcaatctc 3572521 cagcatatga tcgaaatcac gcgctttgca aatcgcaaca accgggccga aaatttcttc 3572581 ctgcatcaag cgggcgtttt catcaacatc tgcaaagatc gtcggctgaa taaagtagcc 3572641 ttttgaatca tcgccttctc cgccggccaa tagcttgcct tcagatttgc cgatttcaat 3572701 gtatttcatc actttgttgt aggatgcttc atgaatcacg ggacccatat acgtatcagg 3572761 atcttctgga ttgccgacag tcagcgtttt ggtcagcgcc acagcttttt ccaccacttc 3572821 atcatacaca tcctgatgaa tgaccgcgcg ggagcccgca gaacacttct gtcctgaata 3572881 tccaaatgct gaatacacga tagaggatgc agcaaggtca agatcagcgt ccttgtcgac 3572941 aagcactgtg tcttttccgc ccatttctgc aattacccgt ttgagccatt tttggcccgg 3573001 ctgcactttg gcagctcgct cataaatccg gcagccgact gcacgggaac ctgtaaatga 3573061 gacaaaccgt gtcttcggat gctcaactaa gaaatcaccg atctccgcac catctcccgg 3573121 aatgtaattc agaacgccgt ttggcagacc cgcttcctcc atgacctcga caaattttgc 3573181 tgccactacc ggggctgcgt cagccggttt taagagaatc gtatttcctg tcacaatcgc 3573241 tgccaccgct gttcccgcca taatcgcgag cgggaagtta aatggagaaa tgacgatgcc 3573301 gacgccaagc gcttcgtaat gatattgatt gacctcgcca gcacggctct tcaccggagc 3573361 cccttccttg agctttaaca tttggcgcgc gtagaactct aaaaagtcta tcgcttcagc 3573421 cgtgtccgca tctgcttcct tccacggttt tcctgcttcc ttcacaagat agcttgaaaa 3573481 ttcatgcttt cttctgcgca aaatagccgc tgccttaaag agaatatttg cgcggtgctc 3573541 cggtctttgt tttttccagg aatcaaatgc ctgcaatgcg gcttgcatcg ctttttcagc 3573601 aagctcttga tccgctgtag acgcgtaccc aatgatctct tctttatttg ccgggttaat 3573661 agaaatgatt ttgcggtccg tttcaatttt ttctccattt atgacaagcg gataatgctt 3573721 gccgagctga gtgtttacaa aggccaatga ctccccaaat gcagttttat tctttgcttc 3573781 cgtaaaatcg gtaaatggtt cgtgcgcgta tgtgactgtc atatgtagtc cccctcgtgt 3573841 tatgaaatat atcttcgcat atgaataaaa atgcaagaat catgccattt tcttgtcttt 3573901 tgctgaaaaa acttgttgaa tcgaacagaa atttgtctaa caggtgatca cctttctctt 3573961 tttccgatct tgaacgcaaa tttattttgc gttttttgct ctttacgcaa aaaacaaatg 3574021 caaaattatt ttgcggaggc ttctcaaatt agacccatcc gcggaaacgc gatgcttctg 3574081 ccgattttct gatgcccgtc atgtaagccg ccaaacgcat atccacttta tgtgttgccg 3574141 ctgtttgata aattgtttcg aacgagctga ccatgacgct tctcagtttt tctgcaacct 3574201 cttcttccga ccaataatat ccttggttgt tttgcaccca ttcaaaataa gaaaccgtga 3574261 cgccgccggc actcgctagg atatccggca caagcagcac gcctctttca ttcaggatct 3574321 tagtggcatc aatggttgtc gggccgttcg ccgcttcaac gacgattgac gcctgaatgt 3574381 tatgtgcgtt tttggctgtg atttgattgg agatcgcggc aggcactaaa atatcgcaat 3574441 ccttttcaag cagctcctca tttgtgatga cgtcagtaaa taaattggtg accataccaa 3574501 agctgtcccg tttatcgagc aaataaggga tatcaaggcc gtctgggttg tagagcccgc 3574561 cattggcatc agaaatcccg atcaccttcg cgcccgcatc gtgcatgaat ttggccagga 3574621 agctacccgc gtttccaaag ccctgtatga tgatgcgcgc gttttgcagc ttgatccctt 3574681 ttttcttcac cgcctcttca atacaaatcg tgacgccctg tgccgtcgct gtttcccgtc 3574741 cttgcgatcc tcccaaaaca agcggtttac ctgtaataaa gcccggagaa tcgaattccc 3574801 gcagccggct gtactcatcc atcatccacg ccataatctg cgaattggtg tacacatcgg 3574861 gagctggaat atcctttgtc ggaccgacga tctggctgat ggcacggaca taccccctgc 3574921 tcagcctttc cagttctcca aatgacattg tccgcggatc acaaataata ccgcccttcc 3574981 cgccgccgta aggaagattg gcaatcccgc atttgagcgt catccaaatg gataatgcct 3575041 ttacttcctc ttcattaact tctggatgga agcgaacgcc cccctttgtc ggaccgacag 3575101 catcattgtg ctgtgaccgg tagcctgtga acactttgac gctcccattg tccattttga 3575161 ccggaatgcg gacagtgagc attctctgcg gctctttcat gagttcatac atatctcccg 3575221 gataacccag cttccgaagg gcttccttaa tgattgtttg ggtagacaga aataagttaa 3575281 gagcttcttt ttcttcatct ttcgagactt gctttgctga catctttttc acctcattgt 3575341 ttttttggcc ggctgtaatg taagcgcttt aaaaaatcag cccgccaatt cctttcttca 3575401 ttggattcac ccttatcatc atgcaagatc cgtaccagct tttgaatcca caaaaaaaga 3575461 gactgaaaac atctcagtct ctgactacaa atctatcgat taacggggat caatcaccag 3575521 ctgcgtttca gcataaaaac tgccgattcc caaaccgttt actacatcgc ctttaatcgt 3575581 gtaagtgcct gcgcgaggaa gagttttacg caccatgaca aggtcaaatt cggatgcgcc 3575641 taacaaatca agcgtaagcg ggagtctgac tgtttttcca tcgtttaaaa tctgtgtttc 3575701 tttcagtgtt cttccattca ctgaatctct tgtcgtagca tgaaacccgt caggaaattg 3575761 aaattctacc gctccaagag aaagcaccgc atttggttta tatgtcactt caatatcaga 3575821 aatggtccac tctttcgtgc tgttaactgt ttttgcctcg attgatgcag actgtgcatg 3575881 agcttggccc gaaggaagta agattgatag taaaacagct gaactgatga ataatgaaga 3575941 tacgaatgaa gttcttttta gcatgacatt tccccctaat tgattgttga aatttggcca 3576001 gagcgtcctc tgcagaaaaa gcgctttttc ataattcgcg aattaccagt tctttttctt 3576061 aaaaattaat ctatcatcat tttccatgga agtaaatgtt ttttaaggaa tattaacact 3576121 tggaattcaa tgagaattcc ttcctgttta tacaaggttc aaatggacga tttccctctc 3576181 tttttctagt aacatctgcc tgacatttta tatcttttat cctattttaa aaaagggcaa 3576241 aaaaagtcga agatgcctct gctcttcgat tgatcacgtt cctattttta tctgaattca 3576301 gtgttccagt taaaaccgat cgtctcatca tcccacggaa ttcttttttc atcaggctga 3576361 tccgggttat acgacatggt ggtaaaatag ataattgtca gcggcgtctc tcccagcact 3576421 ctatatccgt gagccacccc ttttgggatt aataacagca tcgggttgtc ttcgcccata 3576481 taatagacgt ccgtttctcc ttttgtcttt gaatcctctc gaagatcgta taggacaacc 3576541 tgagcgtggc cggttgggaa gaaccagaga tcatcctgct tctcatgata atgaaatgcc 3576601 ttaatcacac ccggatagct tttcgaccaa gaggcctgcc caaaatgctc aaggagattc 3576661 tcatcgtccc ggaccagctc agcaaaaaag cctctgtcat cgctatgctt catcaatttt 3576721 ttcaccttga ctccatcaat cacacgcact gctcctttcc tgcaaatact ctcgtaacgc 3576781 ttcccgccag tggcgggggc ggatgccggc ttcttcaata gcccgatggc tcagcacaga 3576841 gtatgccgga cggggcgttt tgttcccgta ttcctctgtc gttacagaca aaatggctgt 3576901 ttccagcccg ctttcttcca taattgccgt cgcaaactca taccagctgc atatgcctga 3576961 attgctgaca tgatagatgc ccggcggatg gctgaacagc ttgatgaccg cttctgctaa 3577021 atccttcgta taagtcggcg aaccaatttg atcgctgaca acccgaagct cttgtttcgt 3577081 ttcagcaagt ttcagcatgg tttcaacgaa attactgccg ccatgtccgt acacccacga 3577141 tgtcctgatg atcgtgctgt cttttgtcgt taatcgtatc agttcttctc cgagcctttt 3577201 gcttttgcca taaatggttt tcggatcgag gggatcgtct tccctatatg gctgggttcc 3577261 tttcccattg aatacatagt ccgtgctgat atgaacatat tgagctccga tgcgggttga 3577321 ctcaagcgct gtataataag cgccgattcc gttaatcaag tacgctttat caagctcttt 3577381 ctcgcattga tcaaccgacg taaacgcggc gctattgacc acgatatccg gctgataatg 3577441 gccaaacgaa tgccgtactg agcgctggtc agcaatgttc atcatcttct ttgttaacgc 3577501 aatgacctca tatccggctt gcttcagctg gcggcatagt tccaagccaa gctgtcctcc 3577561 cgccccagtc accaatacct ttgtcaatca gatcaccttc tcatcggtca ttgtctgtat 3577621 accactgaat cgtacgcgca atgccttctt caaacgtcac ttcctgccgc cagcccagtt 3577681 cgtttttcag ctttgatgca ttgatcgcat agcgccggtc atgccctttt cggtcttcca 3577741 cgtgggcgaa caattcctca cagcccagat gcttcaaaat gacactcgcc agctctttat 3577801 tcgtgcgttc atttccgccg ccgatgttat acacctcgcc gtcggtccct ttttctaaaa 3577861 tcagcttgat cgcgcggcaa tgatcctccg caaacagcca gtctcggatc tggagtccat 3577921 cgccatacag cggaacaggc aggccctgct tcgcatgacg gataatcgtc ggaatcattt 3577981 tttcgctgtg ctgataaggt ccgtaattgt tgctgcatcg tgtaatgatg gccggaagct 3578041 tgtgggtttt cacataagac aacacgagca aatcagagct tgctttgctg gctgagtatg 3578101 ggttattagg agaaagcggc gtcgtttctg taaacgcggg atcatccgct tttaaatccc 3578161 cgtatacctc atctgttgaa atatgaatca gcttcttggc ttttcctttc aagaccgctt 3578221 ccgccaatcg gtatgtcccc atgacatttg tggtgataaa cggctccgct tgggaaatgc 3578281 ttctgtccac atgcgattct gctgcgaagt gaatgacgcc atcgtaggtc tcgtcaaaag 3578341 cgcggtcgat atcctcctga acgctgatgt ccccttttac aaagcgaaaa cggctgtttt 3578401 gctttaattt ttccatttcc tccgggtggc tggcgtacgt cagtttatct aaaacggtaa 3578461 tgcgcgcatc cgtttccctc agcatgagct ttgtaaacgt gagcccgatg aagccggccc 3578521 cgcctgtaat taaatatgat tttgccatca cttttcgtcc tgtcctttcc gtaaagcctg 3578581 gtgtacaagc tgggaagcga gataaagcga ttcgtgagtt ccggcatcta cccaccagcc 3578641 tgataacaca tcatacgtaa gctggctgtt ttcgatgtat agattattca catcggtgat 3578701 ttccagctcg ccgcgctttg atggtgatat ttgttcaata tatgaaaaca cctctgcatc 3578761 atacatataa atgccggtaa cacaaaggtt ggtcggtggc tgttcgggct tttcgatgat 3578821 ggaacgaatc cgcttgtttt tctcatcaat ctcagcaatc ccgaaacgtt ccgggtcatc 3578881 aacttctttc agaagcactt ttgctccttt cccctgctgt tcaaagcgtt ctgtataagg 3578941 ctttaatgaa tcttcaaata tattatcacc taataataaa atgaaagact cttttttcgt 3579001 aaagcgcttt gcataagaca gcccatccga aatgcccgat gctgccggct gtacttgata 3579061 agtgatagta acgccaagct cttccccgtt cccaagcagt ttgtaaaatt gcggcatatg 3579121 ctccttttgg ctgatgagta aaatgtcttt tattccggct tcctgcagct tcataatcga 3579181 ccagtatatc atcggatacg ggcctacagg aagcaaatgc ttgttgacgg ctttcgttaa 3579241 gggcataagg cgtgagccgt ttcctccggc taaaataaca cctttcacat taacacttcc 3579301 ttacatgcat ttttatatct cttgttcata taaatcttga agaatagctg ttacccgtat 3579361 aatgcctttg ccatccacga gcggccttcc tcccttgtgc aaagaaaggc gaagaggata 3579421 gctgctcata atgcgtgaca tctgatagat gagtgtttca tccggtacaa gctcacccaa 3579481 tccaagatca agagcggcgc cttggtcagc aaatgttttg gctgtagccg tttgatgctc 3579541 aacctgagaa agaacaaggc acggcacgcc gatgcaaatg gcttcatata gagagatgcc 3579601 gccagcgaca atggctgcgt ccgcttgttt catcaaacct gccatatcat ttgtctgttc 3579661 gatcatcttg tactgcggct tcttttcgat ccgccttcgg actgcctctt gatgcggtga 3579721 agcgctcccc atcacaaaca tcatgttttt gtcttttatg tcggggactt gatcagcggc 3579781 agccagcact ttaaaaataa gctgcttcgg atcacttcct cctaatgcaa caaggatatt 3579841 gcggcagtct ttcttaagtg tgtaatcctc tcttgcggcc tgaaaggcgg ggtgaagaat 3579901 aagatagtcc ggaccttcat agatgcgtgt gtttccctga acgtacaccc tgcttctgat 3579961 gtcaccgtaa attccgttaa tgactgcgtc actatattga atcgatttac cgtttttctc 3580021 ttcaaaaaga acaattttcg catctgtctc cgtctttatt ttctttaaca gctctgcagg 3580081 cgcgcctaga atatcaaaca aaagcaaatc aagcttcttg ctttttattt cccggagaat 3580141 aaattcgtgc tgctgcagct ccggctttac gatgacctgc caatgctctt catgaagaaa 3580201 cgcttcagaa tcctgattcg tataaaacgt aatcaagcat cgctgtttga gcccctccgc 3580261 aagcctcttc atccggacaa catggcccat tcccttttca tagccgccgt ctgcgaagat 3580321 cccaacatgc atggctagtc agcctctcgt tcggttgccg catcggggtt ccggttcaga 3580381 agggtgataa gctctgaggc ggatacatcg gggcgctcgc ctgctttttg atagagggcc 3580441 tttatcgatt catagtcttc ctttgtatca atggtcagcc gatattgagg ggcgcgaaat 3580501 cgttccggcg cctctaaaaa ctgaacacga taaagagctg gatgattcct tatatataac 3580561 gtgacatgct cctgatattg atcctccaaa gcctgaatac ggctgatgtc aattaacagg 3580621 ttggcgttga ccacttcgcc gcaaatccct aatggggcat tcaggatata cgtataatcc 3580681 gagccttgat caaaatgcgc ctgaatcatt acatcgagca gctcaggatc gacaaacgga 3580741 ttatcacctg ttaaccggat gatgactgac ggtttaacag cttctatgac cttcacaaac 3580801 ctatcgagga cacgttcttc gctcccgcgg aaaacacgaa agccttgttt gatacagtgc 3580861 gcctctaata tgtcgtcagt ttctttgtca gacgtggcga tgacaagatt atcccgatcc 3580921 ttttggtaaa acgcgctttg ccggacacgg tgaacgagaa tatcaagtaa acgattcgat 3580981 ccgagcggcc gaagcacttt tcccggaagc cttgttgaac ccattcttgc ttgaatgata 3581041 aagagaatat cattcatgaa acgggctgtc cttcagtaaa atgtcatccc agacaatgcc 3581101 tgtgtcggct ggaatgtctc ttacagcccg aacaccgctg gtcagcagtt caaaaaatct 3581161 cgggtgcagc ccctgcggct tttgtccggg ccgaagcact gcgatattgt cttcactaaa 3581221 ggcttcacct ttttgaatcg gagctgttgt aaaaatgcct ctgtatgcaa agtttctgat 3581281 ttctccttcg atggcggtcg ttgttttgta tgaactgcca agcagttttt cagagaccgg 3581341 ctttgtgatc ccctgtttca gctcagcttc cgttttcctg atgccatcga ccatttcttt 3581401 caattcatcc ggatttaatg caaacgagtg gtcagcaccc ggcagatttt tatcgatcgt 3581461 aaaatgcttt tctatcagtt ttgctccgag ccgaaccgcg gcacacggcg cttctgtcgg 3581521 atgctcgcta tgatcggaga agccgattac cgcctcagga aaagcggcgg caagcatcgg 3581581 aatgacgctg aggttgctgt actccggcgg tgctgggtat ttcgccacac aatgcattat 3581641 ggcaatttga ttgtttccct ctgccctgat ggtgcgccaa gcttcgtgaa catcagagat 3581701 ttcagctccg gctgtcgaga aaatcatcgg cctgttcagc cgggcgacat atttaagcag 3581761 cgggagatgg ttaatttcat aggatgcgat tttaaaagcg ctcggcgagg tagactgaag 3581821 cagatcagct gacccctcgt cacataccgt acttaaaaag atcacctgct tttcgcggca 3581881 gtaatccaat agcggtaaaa tccactcagc aggcatttcc atagattgaa ccaaagaaaa 3581941 aatagagacg tccttgcccg ctgccgtctt gtacaaacca ggatctttct ggtacatcct 3582001 atcagcttgg aacatttgaa atttcacggc atccgctccc gcttccgccg cggcgtctat 3582061 cagcgcaaaa gcctgatcaa gcttcccgtc atgattaatc cccgcctcag caataataaa 3582121 aacaggagcg tctttgccta cagttttatt cgcgatctga aacgctgcca ttatttcgcc 3582181 tccttgcccg gccaaatatg ataatagtaa tacgattgtt cagcggtgaa gcccattcgt 3582241 tcataaaggc ggatcgccct tacattgtga agctgcgtcc ccgctgttac cgttctatgc 3582301 ttctgggtct ccggttgttc tatgagattc gccaataaat gaaacgcaat acgtttccct 3582361 tcaaatcccg gctttacagc catcaaatcg agaatgcact catcatctct tgataagccc 3582421 tgaagatagc cgatgacctc gccattgtgt ttagcgacaa tattgaccgc cgcccttcca 3582481 ttcagattgt ttcgtgtcca ctcctgaaat atttcgtttg ctgcatcgcg gctgagatga 3582541 ggatcctgaa aatatctgct ttttgtaaac gagtctcggg ccagctcaca tatcgcttct 3582601 gtgtctccgg gctcaggcgg gcccagttca aaaaatggcg gtgttttgtc ataaaaagac 3582661 ggaggcatcg ccagcttcag caaactcccg acaaagtaag aggatggctg ctgttgtatc 3582721 acatgcgcgg ctccgatatc ttcagccgga acacggacaa agataaaatc cgtttcatcc 3582781 atttggcgta cagtataaaa agcttcaaac agcctcttta gctgcccggt actatttgcc 3582841 gcaagaagtt tgacgttcat gactttcttc tgaagcacct tgctttccca caaagaatct 3582901 tcgtaaagca atacgccttg gagcctgctg ttttcaaaaa ggccgaggga aaattgatac 3582961 ggaacatcca atgtaagctt tctgctttgg agaaattcct caattgcctc tttggagaca 3583021 ttttctttta ccgtatacac ttaatcagcc ccttttacga tatcccgcac agcttcaatg 3583081 acatcatcta catcatcgtc agacattgat ggatagagcg ggagagaaag ggttcgttta 3583141 tagtaattca tggcattcgg aaagtccgct tccttatatc caaattgctt ttgataatac 3583201 ggatgaatgt gtactggaat aaaatgaacg ctagtgccga tattgtattc atcctttaaa 3583261 gccgtaatca tttcgctgcg cgtaaccccg gccttttttt catcaacttg cagaacatat 3583321 agatgccagg cgtgcctgcc gtcatcatgg acaaacggcg tgatcagccc aggaatctgc 3583381 tgaaaagcgg tttgatagcg gccggcaatc tcttctctcc gtttctgcat atcatccagc 3583441 cgtttcagct gatgaagtcc gagggccgcc tgcaaatcaa acatattcat cttatagccg 3583501 ggcgattcga cttcatagta ccagctgcca tttgaagaat aacggttcca tgcggcttta 3583561 ctcatgccgt gaaggcttag cacccgtatc ttatcggcaa gctcctcatc atcagtcgtc 3583621 agcatgccgc cttcccctgt cgcgaggttt ttggtggcgt aaaagctgaa tgccgttgca 3583681 tccccgatag aaccgatcat tctttgctta taagtcgtat ataccgcatg tgccgcatcc 3583741 tccagcacga ataaaccatg attttgggca acagccaata ttgcatccat atcgcaggac 3583801 tgcccgccaa agtggacggg cacaactgct ttcgttcgcg gtgtgacggc cgcctcaagc 3583861 tttaccgggt caatattgag cgtgttttcg tcaatatccg caaacacagg cgtcgctccc 3583921 gtatgaataa tcgtattggc ggtcgagctg aacgtaagcg gagaggtaat gacctcgtcc 3583981 ccgggcccaa tcccttttgc tttcaaagcc aaaaataaag ctgcggtaca tgaattcacc 3584041 gccacggcgt gcttcgcccc gacaaacgcg gcaaactctt tttcaaactg ctgaaccttc 3584101 gggcctttag agagccatcc cgattcaagc gtttctgtaa cctcctgaat ttcttcctta 3584161 ccgattaacg gcaatgagta agggagaaaa tgatttctct tttgcaccat ttctttgcgc 3584221 tcctatcatt ttattcagta tcttcccgcc tgtaatcaac ccctgttttg gctttcagtt 3584281 ccgcaaataa agcatttgtt gattctgcca ccggataatt agccgctatg aatgccaggc 3584341 gcgcctcttc tgctttttga tgcacgtcgg gacttcgaag aacctcaacc aaggtgtgcg 3584401 ccagttcatc cggctggtca aacataaaat cgccaagaga ctcataatac ggatacgagc 3584461 gatttccgga cgattttcct atcagcacag gcttttgaaa cagcatggct tcaagaccga 3584521 ctgtcgaggt ttgcgtcact gcggcatcaa catacggcag caaatcataa agctccagct 3584581 cctttttgat gactctgcat gcttgatgtt ttttcgccgc ctcgtgatac agatcaagct 3584641 tgttttttcc gatttcccac gggtggggtt tgataatgat ttgcagctgc ttctgatcag 3584701 aaagcccctg cagcacaccg gaataaaagt cttctgaaaa gggctgagtg gcaatgagca 3584761 caattttttt agtcggctga aaagcaagtt ttcgatagaa tatggacata tccataggcg 3584821 ttctgttaaa aatctgatcg aagcggggat gtcccgttac gagaatctgc tcgggtttac 3584881 agccttttcg tatgaaccac tctgcttcat acgcaccaaa aacagcttga taggttgtaa 3584941 aaacaggaat gaaggcttca tctcccatca atgcgccatg ctgaagacaa atgctgacgg 3585001 ccccttttct ttgacacatg agagcgagca ccctgctgta aatgtcttct gccgttccga 3585061 caataacagc tgaaatcttt tcctgttcaa acagcgcatc aactgtatca atggcctcta 3585121 taaataaagg aatatctttg aaaagccggt cgcgaaacgc ttgatcacca aatgccgggt 3585181 gatcatcata aggggcgaga agcgaacagg ctgtttcgag atactgcttc gaatcgcctt 3585241 tttggcatga atccgcaatc tcccgcttgc taattacagg cagatcacaa taatgcggca 3585301 aactccatct ggccaaaaca gccgtttttt caggatcaaa ttgatagtaa ttttcgtttg 3585361 aaaaacgcag gtaatcaaag tgcaaaatga ctttcccttt aacaggttcg tcatttgttt 3585421 taacgatgtt ttggattctt tcttcaaaaa acggctgaat ctgtccctca tcgatatgct 3585481 gatccaccga tccgaataat tccggttctt cttccatcat caccctcagt tcagggctga 3585541 tgtattgata aaaattactg ataagcccaa gcggaatccc tttgtagcga agtttgtcaa 3585601 aaagctccac gtacttccgg tacagcaccc aataattgct taaataggcc gacaagctct 3585661 caccccattc caagcttttt taatgattca cgcagctctc ggcaatttcg ctgcggagga 3585721 aggttcctga caaattcatt tttttctaat tcaaacagct gaaagtgaat cgattggtcg 3585781 gtaatataat tcaggtccag ctcctcatcc agtgggtaaa acggataaaa atgattgact 3585841 ctccaaaaga accgggcatc tcctatacgg taaaacgccg ggctttcatc ccaataggag 3585901 ccaaacttct cctttacctt ctcaagcacc gaatacctgt gcatcaccga gcaatgatca 3585961 attgcgcacg gcgcgttcca tgtcacttga gcggcaggcc tgacagtttc ttttacaatg 3586021 tcacgattct cgtttaaatg ataggttttg gaggctgagt aaatcacagc cttttcagga 3586081 tgggtatcga gctcccgcac cattttcagg aggcggtccg gcatatagat gttgtcatcc 3586141 gtcgcatagg tgatatattc accctccgcc atctcaatcg cctgattgat cagtgccgcg 3586201 tatctcgttt tttctgttct ttccttcact ccagatatat cgctttgata aaaacgcact 3586261 cggttatcat tcaaaaaagg acggattaca ttcagcgtct cttcattgga gttgtcatcc 3586321 ataataaaca attcaaaatc tgaaaacgtt tgtgagagta tgctagaaat ggactttgcc 3586381 acataatcgc ttttgttata gctcgtcata atgactgata ctttaggcaa atcctacacc 3586441 tccttcttgg aacttcacac ctgaaactat cgttatctta tgttgcttat gctcaagttg 3586501 cgctagggat acaaaccaat atgcgaaaag tttgtgtatg tttctgaaaa acagcggctg 3586561 cccagagcga aatctgatcg gtccgctgtt ctttttcagc ataatccaag catcagcctc 3586621 ataaggtgaa agagataaaa atcgcaccag cgactaagat cgttttccat cggaggtgag 3586681 tcatcgcgga gcgttcacct atacatccag aacatgtttt gaatggtttt cataaaaagg 3586741 aggaacgata tgaaaccgaa aaaaaatcaa tatcagcaaa tgcaggcatt tgataatatg 3586801 caggggtatc agcctcagtt tggcgccaac ccgtacccgc agcaaggcca aggctcacaa 3586861 atgcagacaa tggggatgca gccaatgatg ccaatgcagc agggacagca aggacaacaa 3586921 ggacagcagg gatttggatt cccgggccag cagcagggcg gcggttttca aattccatcg 3586981 gggcctacac cgtcaggacc gggccaaagc gttcccggca tgctgcctgt tgaggaatct 3587041 tacatcgaga atattttgcg cctgaatcgg ggaaaaacgg ccaccattta tatgacattt 3587101 gaaaacagca aggaatgggg ctcgaagatt tttcgcggcg tcatcgaagc tgcgggccgg 3587161 gatcacatta ttatcagcga cccgaaatca ggaacacgct acctgctcct gacaatctac 3587221 ctcgattaca ttacatttga tgaagaaatt gcttatacgt atccatattc catggcgtcc 3587281 tattcgccaa gataagaaaa aagccaatca ctcatatgat gaggattggc ttttttgttt 3587341 atagatattt gacggctgcg acaacgatca taatccaaga aataataaac gccacaccgc 3587401 cgagcggggt gatcgctcca agaatggaga tttgcgtcac acttagaata tataagcttc 3587461 cggaaaacag cacaattccc gcaaacatca gccagccggc tgtcgtgaca ctgcctatgc 3587521 cggataattt atcagccaga aacgcgacaa cgaataaccc aagggcgtga tacatatgat 3587581 actgcacgcc tgtgtgccaa acctgaagat acttatcagg tattttccct tctaatccgt 3587641 gagcgccgaa tgctccgagt cccacggcaa gcagggcgtt aatggcccct aatatgataa 3587701 aaactttcat ctatctctcc cgccttttcg ttaaactcat atcatttatc ttatcgcacc 3587761 tgcaccaaaa ttcaatgttt gttctccgtt gacacgagat tgtcggattt tctcctgcgc 3587821 caaagctgga actggtcagc tgctattgca gcaagcgtcc ctaatacgag cccgttgctt 3587881 aatagagaaa taaataccgg atgcaatccc tttaacgcag tttcaggaac aaacatgata 3587941 ccgacccctg tcagcagtga gataccgatg atagacctca ccctttttga ttcttctttc 3588001 tcatatgaat caaattcggc aaaggccaga ccgcccattg cggagaacac aacaaaattc 3588061 accgcaaatc caacgggtga cggcaggctc gcaaacgtat tcataaaaaa cgggatcacg 3588121 ctgatcacga taaccagaat actgccgagc ataaacggtt ttttagaagg catcttggtc 3588181 gtttcaataa aacctgcggc tcccgaaatc ggaacaggcg caatagctcc cgtcaaaccg 3588241 ctaagcagat ggctgaatga agctgcaaaa ccggcatggc gttcatgatg ctttccatca 3588301 ggctgtttgc tgaatttttt catggcgatg tccacgacct tcatgctcgc cagcatattc 3588361 acgatcagca agatggtaat aaaaatagaa gtgatgatca ggccgctgtt aaataacggg 3588421 gtcccaaaag gaaacaggga aggcagctga aacagccggt ccggcatttc aatcggcttt 3588481 gcggctccgg cagccgcaaa cagcacccac ccgccgaaca aggctaataa aatagaatat 3588541 tgcttaaaaa acatgatgtt cgaatttgtc attataaaag cggcagcgat cacaacaagc 3588601 gccaggccaa atacaagacc gtccaccccg tcctgtcgat aaccgattcc gagaattcct 3588661 tttataatgg gctgactcag ctgcatgaca agaagcaata aatagacgcc cgttacaacc 3588721 ggagtaaaca attttgcaag tctgtcaatg accttgaaaa cacttaacaa aaagaaacat 3588781 acagcgctta caagaagagc tccctgcaaa ccccgcagtg tgtctccata tgtcgcaaac 3588841 acagttcccg tcagccctgc gtaaatcgta tacactcccc accacaagcc ggctgggctt 3588901 tcattgatcg gcagtctgtg gcctttcaaa cactgaatga cggcggcaat tcccagtaca 3588961 aaaaaagtgc tttgaatcaa tcttgcagaa tctgagtgat ccagatgaaa cgactgggca 3589021 accgccaccg gaacaacaat cgccgcagca ataataaacg ctgtccattg cagcgcgcca 3589081 agaaccaatt tcacgtaagc tcaacctctc tctttaaaaa tcaaataaag actctccgtt 3589141 tccatcctct tcctgcttct ctttttcttg ctttcgatat ttgtttaatc ccgcgctccc 3589201 catcattttt tccatcatca gctggtctgt cgatggcggc gcggcgggac ttggcgtaac 3589261 gctcggctgt atgcggggcg cgctcgcgtt ctccggctga tcaagcacga catcacacag 3589321 agaacggaca accgctacat aacgcttcag ctcctcatcc cgttcagccg tttttgcttt 3589381 ttttagctct tcttccatct tttgaatcaa agcagatata tgaatgttca tgaagcaccc 3589441 tccaaaaaaa taaatgttgt cttcctgcat tttatcaaat tcctgctgaa aacgcagata 3589501 tgagtttgtt attttttctg acaaaccttg cgcgattgac aagcagaaga gatttttcac 3589561 ataataaatc accatacctt acaaaaagga gaaacggaat gaacagcatc ccctctatca 3589621 tcagcaagca taaagcctat tttgcggcgg gacatacgag accgcttgaa tcgagactga 3589681 acattttgcg aaagctgaaa caagccgtca gaactcatga agccgatctc atagccgctc 3589741 tctaccagga tctccataaa tccgagcaag aagcatactc aacagaaatc ggaatcgtct 3589801 tggaggaaat cagctttgtc atgaaacggc tgagaaaatg gtccaagccg aaacgagtca 3589861 aaacgccgtt gactcatcta ggctccaaaa gcatcatcat ccctgagccg tatggaaccg 3589921 ttttggtgat tgcgccttgg aactatccct tgcagctggc gctttctccg ttgattggcg 3589981 ccattgcggc ggggaacacg gtcgttctca agccatcaga atatacgccg gctgtttctg 3590041 ctattctttc caaactcatc agcagcgttt ttccaactga ttatgtcgct atggcagaag 3590101 gcgggcccga tgtcagcaca gcattattac agcagccctt tgactacatt ttctttaccg 3590161 gcagtgtagc tgtaggaaaa atcgtcatgg aggccgccgc caaacaatta attcccgtaa 3590221 ccttggagct cggcggcaaa agtccctgca tcgtccataa agatgctgac attcagcttg 3590281 ccgccaaacg catcgtcttc gggaaattta caaatgcggg acaaacctgc atcgcaccgg 3590341 attatttatt tgtccacgag gacatcaaaa cgaagctcac agaagaaatg aagcgtgcga 3590401 tcagagaatt ttacggccct cagccggaac ggaatccaca gtacggcaaa atcgtcagtg 3590461 agcgccacta tcagcggctg ctcagctttc tgaatgatgg catcccgctc acaggcggac 3590521 aatctgatcc caatcatcac aaaattgcgc cgaccattct cgaacaagtg agagatgact 3590581 ctccagtgat gcaggaggag attttcgggc cgattcttcc gctctttaca taccgcaata 3590641 tcggggaagt cattgagaaa gtccaatcgc gccctaagcc gctcgccctg tatctcttca 3590701 ccacaaacaa agaaattgag cgcgctgttt taggaaatct gtcgtttggc gggggctgtg 3590761 tcaatgatac gttaatgcat gttgcgacgc cgtatttgcc attcggcggc gtcggggaaa 3590821 gcggcatcgg cagctatcac gggtttgaca gttttaacac attcacgcac aaaaaaagcg 3590881 tcgtcaaaca aacgaaccgt ttcgacttcg catttcgtta tccttcctcc aaaaacgggc 3590941 tgcgaatgat tcgaaaaata ctcaaataaa aaagcgcaga tcacctgcgc tttttacaaa 3591001 tccttaatac accaatcaat cggcgcctct cccattttct ccaaataggc attcgcccgg 3591061 gaaaacggtc tgctcccgaa aaatccgttt ctcgcagaaa acgggctggg atgcgtcgat 3591121 tcaatgataa aatgcttgga ggtgtcgatc cgttcttttt tcatttgagc atgccgtccc 3591181 cacaaaataa agataaccgg ccgctctctt tcactcagca cgtcaataat tcggtccgtc 3591241 agtcgctccc agccttttcc cttatgggaa ttcgcctgtc cgcgccttac tgtcagcaca 3591301 gtattcagca aaagaacgcc ttgctttgcc cagctcacaa gcgacccgtg attcgggatg 3591361 ctgcacccga tgtcctgctg cagctcaaga aagatatttt ttaacgaagg cggctgcttt 3591421 acaccgggct tgacagagaa gcttaaacct tgagcctgtc ccggcccgtg atacggatct 3591481 tgacccaaaa tgacgacctt gacatcatca tatgatgtat aatgcagcgc gttgaaaata 3591541 tcccggctgt ccggataaat cgtttgctcc gcgtattccc tcttcagcat ctctctgagc 3591601 tcttgataat acggtttctc aaactcttcc tttagctgat tccaccagct gtcttgtaaa 3591661 agctgtttca agattcaggc ctccttacga acgatgaagt ctggaataga caggctcgcc 3591721 atcccaaacc atttcacttt ttgcttcccg cctcttcatc tcaggctctt caagcaggac 3591781 ggcaaagttt ttcgtcggca gctccccgag tccgtgcttt tcacttaaac gatccaaata 3591841 ttgcttccgc ttggcgccaa ggtcagcaga ctgattgtct cccgcgtcac tgaaggcata 3591901 aatcacgctg gcgcaaggga cacgcttcac ccggtaatcc ttggccgcgc gcaaataaaa 3591961 atcccagtcc cagtaattgt gcacatcagc atcgaaatac ccgatttcat catgcagaaa 3592021 acgtctgtac atgctgcccg acggcacgta tgtagaaaac actctcatat cctcatagtc 3592081 agcggtataa gcaaacaatt tccgtgacac tggatacctt gttccgtttt tctcttcaaa 3592141 cgaaactatt tccgcatcag aatgaacgaa gtctgccgtt tctatttcct ttgccatttt 3592201 ctcgatatgc cctggcgtaa agaaatcatc gtcatcacac agcataatgc aatccccaga 3592261 cgcctctttt acaccggcat ttctcgcagc cacatgcccc gagttctttt ctaaattgat 3592321 gacagcaatc ggcagctccg gataaagtgc tttgaccggc acgaccgatt ccccggcatc 3592381 attcacaata ataatttcat acggcatcaa ggtctggcgg gaaatcgact ccaaaagctc 3592441 acacaaagcc ggaatccgat tataggtcac aattacgata gaaatcttca tgatgctctc 3592501 cttctcattt tcatagtcat gtactattaa aacatatatt ggacgggaga tcagtgggaa 3592561 tatcctactg aaacggcata ctacaatgat agaaacagca aagtggctcc gatcagaagc 3592621 accatgatca gcatcagatc tccaaagaca tgaaagatat ctttcatgcg gacgccattc 3592681 ggaaggataa gacgccacag cttagattga tagaccggca gcagcaccag tgcataagaa 3592741 agacacaaaa atgtaaaagc cggcggcaca aaagcacagc ctgcatcgtc ccaattcatc 3592801 atgatgtctt tcatactaga tccatccaat aaaaacaaag atatcatgag ggctagcaac 3592861 acaaaggacc ccaattgaac ctcaaacagg cgcattttct ggttatatgc aaatcggacc 3592921 gcccaaaacc agacataagc atatgaacat agcagcgtaa gaatggcacc tgctgtaaag 3592981 acgacatcag gcagccgatc aagcagaaaa acaaaaggca agctggctgc catagccaag 3593041 agcatgcagc caccagtaaa caaaaatact gccccatgag ctacaaaacc atataaacaa 3593101 gagctaatcc tcacgacata cacctccttt acatagaaat tctatgtata tacctaaaaa 3593161 atcagacaag ctgacgcctg ccaatataac agcccattcg gccaaataac ggaaataaca 3593221 gcgttgcaaa agcacaagtt ccaacaaacc aaggtgtcaa caaggattga aacagcgcag 3593281 caggaattac attgaataga aaaacaagca taaaaatgac gtttggcacc attgagatca 3593341 gaatcgtatg tagaacaagc ttttctccgc gttttccaaa ctccttcacg ccttgatacc 3593401 caatcagcac ccagtagatc atatatgcag ctaagatcag ccaaacagaa acagaaatgc 3593461 ctttccatac tgcttgaaca aacggtgatt caagccatac atgcattatt gtaatcgcaa 3593521 tgccgacagc gaatagggca ctgttacaga aaagatggaa catcaaaaac gcacgaaacg 3593581 ttactggctg tattttctta aacgaagaaa caatgtcagt tggtgttcca aacgcctgca 3593641 ataaagtctg catagcttcc tcctcactct ttccttcctg aaaagagcga aacagatgat 3593701 gttcaatatg gctctcaatc tcttctatca tcgcctcacc ctcaggaagc cctttaagcc 3593761 cgcttttgat ttcggataca tatgtttctt tatccatttt gtccgctcca cttcagtatt 3593821 cggtccatca tggctgaaaa tacgctccat tccttcgtgc gttccgccag cacttctttg 3593881 ccctcgtctg taatccggta atatttgcgg tccggtcctt tctcctgctt ctcccagtag 3593941 gaagaaatat acccttggcg ttcaagcttg tgaagagaag gatacaaggt cccttctttc 3594001 atctgcagtt catttccgct gcggcttccc atttctttta caagctcata gccgtacatc 3594061 ggccgctcgt tcagaagcgt caataccaat ataaccgtgc ttcccttaac cagctcacga 3594121 tttaacatct caaaacccct acctagtttt cttatgtagc attttacgaa agcccgttga 3594181 gattgtcaaa tgattcctat agatcttcta tattgtgata cagagaaaat ctaactataa 3594241 tgaaagacaa aacatgatgg aggttcaaga catgtctatg cataaagcac tcaccattgc 3594301 cggctcagat tccagcggcg gtgctgggat tcaagctgat ttaaaaacat ttcaagaaaa 3594361 aaacgtatac gggatgaccg ccttaacggt gatcgttgcg atggacccaa acaacagctg 3594421 gaaccatcag gtattcccga tcgatactga tacaatccgc gcccagcttg caacaattac 3594481 ggacggcatc ggcgtggacg ccatgaaaac aggaatgctg ccaaccgttg acattatcga 3594541 gcttgcggca aaaacgatca aagaaaaaca attaaaaaat gtggtaattg acccggttat 3594601 ggtttgcaaa ggtgctaatg aagtccttta tccggagcac gcccaagccc tgcgtgagca 3594661 attggctccg ctagccactg tcattacgcc aaacttgttt gaagccagcc agctcagcgg 3594721 catggatgaa ctaaaaacag ttgacgatat gatcgaagcc gcgaaaaaaa ttcacgcact 3594781 cggcgctcaa tatgtcgtca ttacaggcgg aggcaaactc aaacacgaga aagccgttga 3594841 tgttctctat gacggagaaa cagcggaagt ccttgaaagc gaaatgatcg atacgcctta 3594901 tacacatggc gcaggctgta cattctcagc agccgtgaca gcggagcttg ccaaaggtgc 3594961 ggaagtcaaa gaagccattt acgcagcgaa agaattcatc acagcggcca ttaaagaatc 3595021 cttcccgcta aaccagtatg ttggtcctac gaagcattct gcactgcgcc tgaatcaaca 3595081 atcataaaaa aaggggctgc cttacagaga ggcagccctt tttaaatcac cgaagacttt 3595141 tcacagaaaa aactgccgat cccatcggca gcctgtttat ttgattttta aattgtttgc 3595201 agatttcctc aaaaatgttt ctatcgactg aacaaaaagt gcatattcct tcatttgttc 3595261 atatgcccgc gtgagaattt ccgccgtttc actgtgcggc gttgttccgc caagcatttt 3595321 tttcagctga agcagcacat ccttatattc ttctcgctta tcttcaactt ggttagcagc 3595381 cttttccaaa cattccggtg ttatcttctg ttcatgtata ttcaagaaaa caactccttt 3595441 tacagaaaaa aatagtaggt tatcgttgaa gaatagcaca gatggctcag atttcacata 3595501 agaaaataga aggattttct acataagtgt ccaaattccg acattcattt cagatttccc 3595561 ggtcgcactg gctgttactt catgatttcc cgggaaagga aaatatcttg cactcaagac 3595621 ctcttctccg ttattgataa agatttccac agatgacgcg tcgagaaaca tgtgtacggt 3595681 atgcaaatcc ttgatgcggc aatgtctcgc ttctgttctt tttccgtcaa agctctttcg 3595741 ttccagcgta acaatcccct cgtctttatg gaaggaaaac gtagccgttc cgcggatact 3595801 gattgaaaag ccagactccg tatgaatgtc ttccagtaga atctcagttc tttcaggttt 3595861 ttccactgga agcgcaccag atgatccatg catgttgatg tgtatttttt tctcatttct 3595921 gcgcatggct tttagctcag gcagcggctg ctgaatcagc ttctgtcctg aaagcgtcag 3595981 ctgtctcggc agcgtcatgc agtgaatcca gtggcagtca atggtcggat gggacccttc 3596041 atcctgatca ggcaccgcca tccatgcaaa taaaatccgc cttccctgat cgtcttcaag 3596101 tgtttgcggc gcgtaaaaat caaaaccttg atcaagctcc gtaaattcac catgcttcag 3596161 ttcaggcttg ttataatcga ggcggccgac aaaataacct gattgatata cgttctgata 3596221 acggaaaccg tcagcctcaa gcccttgagg cgaaacaatc agcacatccg atccttgaag 3596281 ggaaaacaaa tcagggcatt cccacatgta tccaaaatcg tccagcccgt tgaagcccgc 3596341 gccggttatc gggccaagaa atctccactc tgtcaggtta tcagaagcaa acaacacagc 3596401 ctgccctttc aaattctctg tttgcgcacc aatcaccata taccatgtgc cttcatgctc 3596461 ccataccttc ggatcgcgaa aatgcgccgt atatccttcc ggaaggcggg cgacgacacc 3596521 ctttttctca aaggacagcc cgtcgtcaga aacagcaagg cattgatacg tttcccgatt 3596581 tccatcctga tccctgacat ttcctgtgta aaaaagatag agccgatcgt ctttcgtgac 3596641 agcgctgccc gagtagcagc cgtttttatc aaaccaatca ctcggagcca gcgcaatctc 3596701 ttcccgcttc caattcacaa catcctgtgt cgtataatgc ccccaaaatt ttgcgccgtg 3596761 ccccgtctga aacggctgcc actgaaagaa tacatgatag ctgcccttcc aataaatcac 3596821 gccattcggg tcattcagca gcccaaccgg cggcatgata tgaaaatgct ggcggtgcgg 3596881 atcgctgtta gcgatgggct cttttttctc cacttcttca taagcccggc gacgaagctc 3596941 ctggtcatgt gctgtcattt tttcctctcc tcatcctcat taatcttcat gacaaatgct 3597001 gcaatgaacg ctgacactgc cgcaatcgcc atgccaatca gatagtgaat caagttgctg 3597061 aagccaaacg gagccgcaat ggcgatcatc ggaattcccg ttaacccgta agcgtttgca 3597121 gctacatgtg taaagacgac atatgcccca cccaatgcgc ctccgatcat cgcggcgata 3597181 aacggttttc ggtagcgcag attgactccg aatatgacgg gctcagtaat gccgagaaaa 3597241 gcggaaaatg ctgccggaag cgcgatttct tttgtctttg cctttttcgc cataaagaag 3597301 acggcaagac ctgccccgcc ctgtgcgaca ttcgccattg accagatcgg cagcaagtag 3597361 tttttgccta tatctgcaat tagccctgcc tcaatcgcat ggaagctgtg atgaacgcct 3597421 gtcagcacga tgagtgaata cgtgcccccg aaaatcagac ctgcgacaaa accggcatgg 3597481 tcatatacat aagttaaagc aaccgtaatg ccggagccaa gcgctctgcc tagagggcca 3597541 atcgcgataa aagcaacaaa cccggtgaca atcacagtaa caaatggtgt aacaagcaaa 3597601 tccaccgcat gtggaaccac ttttctcgtc catttctcta ccttgctcat cacatacacc 3597661 gcaagcagga cagggataac agttccctgg tagccgagaa gagcgatatc aaatccgaaa 3597721 agatgcatgt aatcaggtgt cgcttccgcc aatccccatg gatttaaaag attcggatga 3597781 atcatgattc ccccgatgac cgctcccaag tatggattgc tgccaaactc ttttgaagcg 3597841 ctgaccccga ttagaatcgg caagaaaatg aatgctgcac ttgaaaacat atcaagcagc 3597901 tgcaaaagcg cagaatcctt gctcatccaa tgaaacgcat tgatcatacc cagcaatccc 3597961 attaataggc cgctggctac aatagctggg atgattggaa caaaaatatt agaaagcgtt 3598021 ttcgcaaatc tcgcagcggg attcagcttt tcttttgccg catcctgatg attgacgtgt 3598081 tcttcacgct cgatatcagc ttctttagaa aaggcatcga atactttatt cacaaggcct 3598141 gttccgaaaa tgatctggta ctggccagag ctgctgaaag cccctttaac gccatcaagc 3598201 tcttctactt gtgcttgatc tatctttgat tcatctttca tcactaaacg cagtcttgtt 3598261 gcacaatgag ccgcgctgat aatattttct ttccctccga gaagctcaat gaggcgtttt 3598321 gcagtctctt tgtaatccat ctatttctcc cccttttatt taaacaaaaa agacctaaaa 3598381 ttcgccaacg aataaaggac acagcgatcc tttttcattt acgcaaattt taggtcttgc 3598441 ctgctttacc agtcacaatc ccgcttattc agattaagaa tacgctttca tcataaatca 3598501 tgatagcgtt ttcgtcaact atttttttag ttaaatagtt tgatataaca tgtagacaaa 3598561 aattcgtaaa aattaattgt gaaatacttc acaatatcgt gctatactat gctcaatcat 3598621 gaaagaaagc aggaaaagac aatggaaact caagcattac aaaaggttga acagtatgct 3598681 ttgaaaaaac aaaacatatt cgcttcaagc aaaatccgtt atgtgcttcg gtccattttg 3598741 gccagtatat ttattggttt tggcattaca gccgcaagca aaacaggcag ctatttcttt 3598801 atggctgatt ctccgtttgc ctttccggca gccgctgtca ctttcggggc cgctattctg 3598861 atgattgctt acggaggcgg agatttattt accggcaaca ccttttattt cacctatacc 3598921 gcgctccgga aaaaaatcag ctggcgcgac accctatact tgtggatgtc aagctatgcc 3598981 ggcaatttaa tcggcgccat tctgtttgcc atcctgatca gcgcgacggg actttttgag 3599041 gagccttctg ttcattcctt tttgattcat ttggcagagc acaaaatgga gccgccggct 3599101 tccgaattgt ttttcagagg aatgctgtgc aattggcttg tgtgcctcgc ctttttcatt 3599161 ccaatgtctc tcaaagggga aggagcaaag ctttttacca tgatgctttt cgttttctgc 3599221 ttctttattt ccggctttga acacagcatt gccaatatgt gcacattcgc catctcgctt 3599281 ttgatcgagc accctgatac agtgacactg atgggagcag tcagaaactt aatccccgtt 3599341 acgctcggca atctgaccgc gggaatagtt atgatgggct ggatgtacta cacactgaat 3599401 cctgatcaat aaaaaaactt ccagagatca ctccctgcaa gtcaaagcgg ttattccgag 3599461 agatcttgaa gacgctggac atgcagcgtg atatagccgg cctcggattc cggcaaatgt 3599521 aattgatatt catttttcaa aaactccgcc agctccagcg cacattgata ggcgaatgaa 3599581 tacttttttt ggatgaaata aagcatctcc tcgtccatac gatggagcgc ttcatttgat 3599641 tccaaccggc tgaccgcgta tcgcaaatgc gtgacaaggc gttgatagga aatgctgttt 3599701 tcatccacct ttcgattaaa gtattgtttt attttctcta tcatttcttt gatcatggtc 3599761 gtatgcttca gcgctgaata catgctctcc gcatccatct tcgccgtatg gatgtgaagg 3599821 gcaatataac ccgcttcatc ttcaggcaga gacacgccca atgtctcttt tacatgtccg 3599881 atcgcccaca ggccgatctc atattctttt ttatagagcg cctttatctc atgcagcaat 3599941 ttattctgca caagcagccc attttgaatc ctttcgatcg caaaggacaa atggtcggaa 3600001 agcgcgatat gaatgtgatc gctcagcggc gccgcgagct ctccttccgc atagctgatg 3600061 atatcctcag ctatttctat atgctcctcc ggcagtgttt gcaggatttg tttgaacttt 3600121 tcattctcgt cgcgcacgac aaagatcttt tccactttat tcatagggat gagatcattt 3600181 ttcttttttt gaaaagcgat tcccggtccc atcacgattt tttcctgatc atcctctttt 3600241 attaaagccg cattgttgtt taatacttta tagattttca agaggttatc tctcccgcca 3600301 atttgctttt gactgggatt ttacctcctt ttgaccgcca tgtaaagatg cgggcccgct 3600361 ctctcctgct ttggcgattc cttgaaggct tgcaaacatc ttcttttata aagcgcggcg 3600421 gctttcgctt tctgcttttc ttcctcattc acagccatcc gccattcata aaacgaaacg 3600481 agtcctgcgg cctgcacagc cgcctttctt tggtatgtac gctgagccga atagaccgcg 3600541 gcagccgcag tttttctgtc cggcgtcacc cagttcatca aaaagaccat ccacacccgt 3600601 aaagatacaa gcaaacgttt catagaaaaa catccctccg cttctttttg gcaggcagcc 3600661 tttttagcag cccgttttct cagccgcagc ccgcaagaaa agacggccga tttcttttct 3600721 cgcaaactag cggctctagc aaaactcatg actctatgat agaccgtgga aagagaattc 3600781 tttgtcacaa tatgagtgaa aaaaccaact agtttttaga agttttgttg aaagctgaaa 3600841 gaattgaaat gaaaattgga gaaccgcttt gaaaacttta tacacaagtt atcccaaaga 3600901 taagaacaac ttaatcacaa gagatatcca catgtccaca aactctatct atattttgta 3600961 tacgaacgta tattcctaac tatatatata cacaggttta ttcacttata cacagggttc 3601021 tgtgtataac tccttcgtta tacacaaaca aaatccaata aatggtccaa atgacacaag 3601081 gatttttttg aattttcaag aaatatatac tagatctttc acattttttc taaatacaaa 3601141 gggggaaaca cattgaaaaa ggggatcatt cgctttctgc ttgtaagttt cgtcttattt 3601201 tttgcgttat ccacaggcat tacgggcgtt caggcagctc cggcttcttc aaaaacgtcg 3601261 gctgatctgg aaaaagccga ggtattcggt gatatcgata tgacgacaag caaaaaaaca 3601321 accgttatag tggaattaaa agaaaaatcc ttggcagaag cgaaggaagc gggagaaagc 3601381 caatcgaaaa gcaagctgaa aaccgctcgc accaaagcaa aaaacaaagc aatcaaagca 3601441 gtgaaaaacg gaaaagtaaa ccgggaatat gagcaggtat tctcaggctt ctctatgaag 3601501 cttccagcta atgagattcc aaaacttcta gcggtaaaag acgttaaggc agtgtacccg 3601561 aacgtcacat ataaaacaga caatatgaag gataaagacg tcacaatctc cgaagacgcc 3601621 gtatctccgc aaatggatga cagtgcgcct tatatcggag caaacgatgc atgggattta 3601681 ggctacacag gaaaaggcat caaggtggcg attattgaca ctggggttga atacaatcac 3601741 ccagatctga agaaaaactt tggacaatat aaaggatacg attttgtgga caatgattac 3601801 gatccaaaag aaacaccaac cggcgatccg aggggcgagg caactgacca tggcacacac 3601861 gtagccggaa ctgtggctgc aaacggaacg attaaaggcg tagcgcctga tgccacactt 3601921 cttgcttatc gtgtgttagg gcctggcgga agcggcacaa cggaaaacgt catcgcgggc 3601981 gtggaacgtg cagtgcagga cggggcagat gtgatgaacc tgtctctcgg aaactcttta 3602041 aacaacccgg actgggcgac aagcacagcg cttgactggg ccatgtcaga aggcgttgtc 3602101 gctgttacct caaacggcaa cagcggaccg aacggctgga cagtcggatc gccgggcaca 3602161 tcaagagaag cgatttctgt cggtgcgact cagctgccgc tcaatgaata cgccgtcact 3602221 ttcggctcct actcttcagc aaaagtgatg ggctacaaca aagaggacga cgtcaaagcg 3602281 ctcaataaca aagaagttga gcttgtcgaa gcgggaatcg gcgaagcaaa ggattttgaa 3602341 gggaaagacc tgacaggcaa agtcgccgtt gtcaaacgag gcagcattgc atttgtggat 3602401 aaagcggata acgctaaaaa agccggtgca atcggcatgg ttgtgtataa caacctctct 3602461 ggagaaattg aagccaatgt gccaggcatg tctgtcccaa cgattaagct ttcattagaa 3602521 gacggcgaaa aactcgtcag cgccctgaaa gctggtgaga caaaaacaac attcaagttg 3602581 acggtctcaa aagcgctcgg tgaacaagtc gctgatttct catcacgcgg ccctgttatg 3602641 gatacgtgga tgattaagcc tgatatttcc gcgccagggg tcaatatcgt gagcacgatc 3602701 ccaacacacg atcctgacca tccatacggc tacggatcaa aacaaggaac aagcatggca 3602761 tcgcctcata ttgccggagc ggttgccgtt attaaacaag ccaaaccaaa gtggagcgtt 3602821 gaacagatta aagccgccat catgaatacc gctgtcactt taaaggatag cgatggggaa 3602881 gtatatccgc ataacgctca aggcgcaggc agcgcaagaa ttatgaacgc aatcaaagcc 3602941 gattcgctcg tctcacctgg aagctattca tacggcacgt tcttgaagga aaacggaaac 3603001 gaaacaaaaa atgaaacgtt tacgattgaa aatcaatctt ccattagaaa gtcatacaca 3603061 cttgaatact catttaatgg cagcggcatt tccacatccg gcacaagccg tgttgtgatt 3603121 ccggcacatc aaaccgggaa agccactgca aaagtaaagg tcaatacgaa gaaaacaaaa 3603181 gctggcacct atgaaggaac ggttatcgtc agagaaggcg gaaaaacggt cgctaaggta 3603241 cctacattgc tgattgtgaa agagcccgat tatccgagag tcacatctgt ctctgtcagc 3603301 gaagggtctg tacaaggtac ctatcaaatt gaaacctacc ttcctgcggg agcggaagag 3603361 ctggcgttcc tcgtctatga cagcaacctt gatttcgcag gccaagccgg catttataaa 3603421 aaccaagata aaggttacca gtactttgac tgggacggca cgattaatgg cggaaccaaa 3603481 cttccggccg gagagtatta cttgctcgca tatgccgcga acaaaggcaa gtcaagccag 3603541 gttttgaccg aagaaccttt cactgttgaa taagaaaaag ccctgccgat tcggcagggc 3603601 tttttaaaga tcagtcagca aacgcctcct gcaataagcg atacgatcgg agcttatctt 3603661 caaaatgatg cgtgatggtc accaccatga tttcctctgt ttcatacgcg ttactcaaag 3603721 ctaacagccg ctccttaacc tgttctttcg taccaacaat cattcgattt cgattatcag 3603781 caattcgtct ctgttcataa ggagaatacg tatttttccg aacagcttca tacgaaggaa 3603841 ctccctctaa aggaataccc tgctctcccg ccaaaagtgt aaaatcaagc acagccccaa 3603901 gctcctctgc cttctcctcc gtgtcagcac aaagaacaaa aacagcaact gccgctcgag 3603961 gcgtatctcc taacacagac ggtttgaatc gcctcttata ctgtctgaca gtaccctctc 3604021 cgccctctcc attgataaaa tgggcaaaca tatagccagc gccagattca gctgcgagca 3604081 gcgcgctttc tccagatgag ccgagcagcc acacatccgg agccgttgaa atatgcggcg 3604141 cagcggtcag attcggaaaa cggtgtttgt catccgccaa atcatgcaaa tacatggtca 3604201 gctccttaat ttgctgcgga tactgatcag cattgcgctt accaccgtca ttcagcgccc 3604261 atgatgcaat cggcattccc cccggtgctc tgccaagccc caggtcaatt cttcctggtg 3604321 tcagcccctc cagaacacga aagttttcag ctactttata agcactgtaa tgcggcagca 3604381 tgactcctcc tgatccaaca cgaattcgct ttgttttcgc tgctatatga ctgattagca 3604441 cctcaggact ggaccctgcc agccgttttg aaaagtgatg ctcagaaacc caaaatctct 3604501 tatatccaag gtcctcagca gcttgggcaa gcgcaacggt ttgctgtaag gccgtttctg 3604561 cattgctgcc ctctgatact ggagattgat ctaatatact taatgaaacc atccctacca 3604621 cctcatcctc atcgtatcac tgatccccta ttttttctcc aaagccgctc acactgctta 3604681 tcagtgtccc ctatcattcg ccatttattt gtgaaagcat gtccctattt gtcggaatat 3604741 gttacacgtg aaacataaaa acccctccag acggagaggt ttgctttagt ttttattaaa 3604801 gcccttttct ttcacgtagt catttaaata cgtacgcggc ttttgcttca taaagttcag 3604861 tatttgatcg gaccacgttt cttcccgctt cccgtttgtt ctttctctat agtaatcaga 3604921 aatggttttg tcatacgtat tcatagtatg acggaaatcg tctgtgttca cattatacgt 3604981 attttcatga taaacggcct gctttggcaa tctcggtttt ttgccggaaa ggttcgcagg 3605041 atggcctact gccagtccga aaagcgggag cacatggtca ggcgtttgca gcacctctgt 3605101 caccttgtcc aattcattcc gaatgccgcc gatatagcaa atgccaagcc ccatggattc 3605161 agcggcaatg ctcatatttt gcgctgccag cgccgcatca atcaagctaa ccataaacat 3605221 ttctgtattc tcgagcagct cagaaatatg ttcacctttt tcctcagcca gttgttgatg 3605281 gcggtacaaa tccgcacaaa atacaaaaaa gtgtccgttc ttctcaacgt aaggctgatt 3605341 cccagcaagc acggacagct cacgtttttt ctcaggatca gaaaccccga taatcgaata 3605401 tgcctgcaca tagctggatg tagacgcagc ctgcgcactt ttcactaatg tatcaatttc 3605461 ttcagctgtc aaaagctgat cagtaaaaga ccggattgac cgatgattca aaatggtttc 3605521 gattgtgtta ttcatcacaa aaacctcctt atcacttttt atcatatccg aaaaaaagtg 3605581 atctcaaaag tgaaatgctc tgcacaaaaa aagacagcct ctgtaaaggc tgtctgcata 3605641 tcaagaatta aaaagataac ttctgtattt cgtcagctgc acacttgcat tatatacaat 3605701 cccaaatccg attaacgtgg aaagtgtcga gcttccccca tagctgacaa acagcagcgg 3605761 aatcccggta acaggcataa tgccaatgtt cattccgata ttctggaatg tgtggatcac 3605821 aattaacgcc gtatagccaa cgcaaaagaa agaagcgaaa cggttaaacg gatgtatttt 3605881 gtctatcaga acaacaagcc tgtagattaa aaagaagaac atgatgacaa caattgcaca 3605941 gcctataaag ccaaatgact cacctattat agaaaagata aagtcagtcg tactctctgg 3606001 aacataaacc ttcaaattag aaataccatt acctaaaata ccaccagatc ctattgccat 3606061 gatggcctgg tcaacttgcc agctgtcatt tgaatcttcc tgtgtctcat ttgaagcaga 3606121 cacccaagaa gtgacccgct taatttgata atcctgtatt ccaactgatt tagcaacgtc 3606181 aggaaagttt atcattacta ataaaattaa tgaaatgagt aagatacctg aaccagctat 3606241 gatcgcaatc aatttccaat ttatccctga cataaaaacc attacaagaa cgataaacat 3606301 acatattccc gcagtcccag catcctgcat caggataaga cctacaggaa taactgcgac 3606361 acccgcaatc tttaataaca agtggatatc atccctaagc gtccgaactc ctttaggatt 3606421 tgcttttcca ataactgaag caagcatcat aatcaaacca accttcataa actctgacgg 3606481 ctgtattgtt attctaccga tcctaaacca actttttgcc cctttaataa caggtgcaat 3606541 agactcggga ctgattttaa gaataatcaa agataaaata ccaatgataa aaatatataa 3606601 acttaacttt tcaagctgtt ctaaatcaaa gtacaaaaga actgtaatgg ctacagcccc 3606661 caaaagataa aacacaattt gctgaatcca atccgtgttc ccatactgcc caaactgacc 3606721 ggcagcatat attgatacta cgcttataat aaaaaacaca ccaaatataa aaatcaaatc 3606781 cccctggtaa aaggggcttt gctgtttctt atatcgactc attctatccc gccttacatt 3606841 ttcatcggaa aatcactaat gtttattata catgaaccac gttcaagatg acacgtgaag 3606901 ctcgcttcct tttatgtttt ttcagcattt gcggcgcttt ttcagctaca cgaaatatga 3606961 cgtatcataa accgaaatgt ttcgattgac acaaaacttt tcaaatgaaa aaaacgccat 3607021 accaatagaa tttgttaaaa aacgaatgcg ataatgtgtt atgttcccaa ataatgtgat 3607081 acctcatata gaaatagcta aaaattcaga gccccatgcc catacattct cctagcacat 3607141 taaacgaaaa aataagacga tagatccagt ccatttctgc aaaaacacgt atcaatttct 3607201 ggaaaacatg gtataataat tgtaacagaa tgttcaaaaa acaatcacaa aacagacaca 3607261 actcagttcc tctatttcat ttttgtaaac gttatcacaa aatgaaagga gacgggtatg 3607321 atggacatgt tttttgctta cttattggtt gccagcgcaa cgcctctctt tatttggctt 3607381 gataacaaaa aagtcgcact ctcagctatt ccgccaatca ttttaatgtg ggtattcttc 3607441 ttcttttacg caacagaaag cctttctcca cttggacaca ctctcatgat tatcttgttt 3607501 gccgttaacg tcattgtcgc tcatatcgcc gcatttatca tttacggcct tccgtatctt 3607561 cgcagaaagc gaagcagctg aagacagcaa aaaaccctct tccactgaag agggtttttt 3607621 gtattattcg ttatggcctg aatgctctga gtgttcagcg cctccaggag gatttccgtc 3607681 catatggtca ccatggtgat agtgagccgc gaaaatccag atggatccaa gtacgataac 3607741 gatcgcgcca aagaatccga acagcgtgtt tccgacttgg atcgtgccgt tttcgctctc 3607801 tgtcatatgc atgaacatga gaagctgcag cgccgcctga atgaaggcga agccgaagat 3607861 aatccaaagt tttgctgatg agctcaggtc agtatacact gcaacccata gagccagcag 3607921 ggtcaaaacg atagacagga taaaacctac aatgtgtttc catggaaagt gactgtgttc 3607981 agcagatttg tttgccattt tacagacccc ccaatcccat gagatagaca cctgtaaaga 3608041 tgaaaatcca tacaacatct aagaagtgcc agtacaagct tgagataaag attttagatg 3608101 aagtttgcgg agttaagccg cgtttcttca actgaatcag aattcctgtg atccagaaaa 3608161 tcccgattgt tacgtgagtt ccgtgagttc caagtaaaac aaagaatcca gaccagaacg 3608221 cacttgtact gagagccgct ccttcatgta catagtgaac aaactcgttg atctcgcatc 3608281 cgacgaagcc ggcaccgaga agaagagtga taattgtcca aatgactacg ccttttaaac 3608341 ttccgcggcg catttcatga acagcgatcc cgcaggtaaa gctgctgatc agcagcaaga 3608401 acgtcataat cattaccaga ttgacttcaa atagttcgtc tggcaagaca cctccagctg 3608461 ttctgttttt aagaacgaag aaggttgcaa atagtgttga gaacaacaca atttctgccc 3608521 ctaaaaagat ccaaaacccg agaatattaa gtctgccggt ttcagattga tattccatag 3608581 gcgcgttaga attgccgtgt tctgcatgtt ccataactca cgcctcctta ttcggaaatc 3608641 tttctttccg tctcttttat ttcatcaaca ctaatgtagt agccgttgtc gtattcgaat 3608701 gaacgcagaa ccatgcagag caggactccg atcaatccga ctacgcccat ccagtaccat 3608761 tcaaagacaa gtccaaagcc tgcgagaccg aaggcaacag acataaagaa cggtctgcct 3608821 gagttgcttg gcatatggat tttcttgaat ttgctttcag ggtataattc agttttttct 3608881 tctttcatat gcaggaatgc atcttgagat ttgacttcag gaagcaccgc aaagttgtaa 3608941 tgcggcggaa tcgcagaaga agtcgcccaa tcaagcgtac gtcccacacc ccatgaatct 3609001 ccgctgattt cacgagtaga gtaacggaag ctgtagtaga tgttatagca aaggattaag 3609061 aatcctacac ccatcatgaa agctccgact gttgagataa agttcaatgt tgtccagccg 3609121 tcattcggtc cgtatgtgta aatacggcgc ggcatgcctt gaagccccaa gaaatattgc 3609181 gggaagaaac aaatattgaa cccgatcata aagatccaga agaaccattt tccgattctt 3609241 tcgttcagct tgtggccgaa catttttgga taccagaaaa taaatccggc gaaacaagca 3609301 aatacagtac ccgcaatcag cacatagtgg aagtgagata caaggaagta cgtattatgg 3609361 tattgataat ccgctgctgc catcgcaagc ataacccctg taaccccgcc gataacgaag 3609421 ttaggaatga acgcaagcgc ccacagcata ggtgttgtaa agctgattcg gcctttatac 3609481 attgtaaaga gccagttaaa gattttaacc ccggttggga ttgagattgc cattgtcgta 3609541 attgagaaga atgagttaac ggacgcactg ttccccattg tgaagaagtg gtgagtccaa 3609601 actaagaaac tcaatacaga gatggcgata atagaaccaa ccatcgcttt gtaaccaaac 3609661 aattgttttc ttgcaaagct tgagatgatt tctgagaaaa taccaaacgc cggaagaata 3609721 acgatatata cttcaggatg tccccaaatc cagaacaagt tagcccaaag catcggcata 3609781 ccgcctgctt ccaatgtgaa aaagtgagcg ccgaacaaac gatcaaatga taaaagtgct 3609841 aatgctactg taagtacagg gaacgcaaac acgataataa ccattgtgat cagtgttgtc 3609901 catgtgaaca tcggcatacg cattaatgtc atgccttttg ttctcatttt taagattgtt 3609961 accataaagt tgatccctgt catcagggta ccgataccgg caatctgaag tccgaggagg 3610021 tagtagttct cacccggccc agggctcatg tcgttacttg caagcggcat ataactcgtc 3610081 cagcctgcgt tcggagaacc tccgataacg aaagaaatat tgaaaagcat cgcccctaca 3610141 aagaacgtcc agaagctcag gttgttcaag taagggaacg caacgtcgcg ggcaccgatt 3610201 tgaagaggca caacaacgtt gataagaccg attaagaacg gcatcgccat gaagatgatc 3610261 atgattgtac cgtgagttgt aaaaatttca ttatagtggt ttgagtctaa aaaactgtta 3610321 ttcggaagcg ctagctgggc acgcatcatc agaccgtcga caccgccacg gaataacata 3610381 attacagcag atataatata catgattccg agttttttat ggtcaacagt agttatccat 3610441 tcagaccaca gccatttcca ctttttgaag taagtcagaa caaaaataat ggcaatggtt 3610501 gaaagcgcaa tggaaacttg tgcgcccaga attaatgggt caccagttac gaaaaattcg 3610561 tcccatttga atttcatgca ggcttcctcc tttcctgatc aatatcattc ttctgtatca 3610621 tcagacttct taaattcgtt tttctttacg ttttcaaacg gatctgtttt agaatgcggt 3610681 gaaacggctt gatagccaag gcgtttgcgc gcctccatcg cgtactcagc gtcttgtccg 3610741 tgatcaacgt atttcaagtg agtagaagag aacgttaatt cgtccacatt ttcaggaagc 3610801 atcaattcat catacttctc ttttgtcagc ttaggagcct cgttctgagt ctttttcacc 3610861 cagctgttaa agtctttttc tgtgactgca ttcacatcaa actcttggtc tgcaaaatgt 3610921 tcacctgtga agttcgcgtt gcggccttcg taagtaccca ctttgtcagc ctgtaagtat 3610981 tgatccatca gcattcctgc catcgcatat ttttgccctc caagctgagg aatccatagc 3611041 gaagccattg aatctgcaga tgagattttg aacaagatcg ggcggtcgac aggaatgttt 3611101 aagtagttga ccgtttcaat atcctgttca gggtagctaa atacccattt ccagtctacc 3611161 gaagtagcat aaacaacaag aggctctttg tcttttgttg cttcaggagc tttttctaac 3611221 gaatatatcg tctgtactgt tggcacagaa agtgcaatga cgattaaaat tgggatcact 3611281 gtccagacta cttctaaaaa cgtgttaccg tgaatttctg ggttataaga tccattatct 3611341 ttgcctttac ggtcgcggta ttttactaaa ataatggtaa atagaacaaa gacgaccccg 3611401 acgataaaca gcataaatcc gatagataac aggattaaat cactttgctg ttcagctaca 3611461 ggtcctttcg gatctagtac tgaagcattg ctgcatcccc caaggacgaa aaccacagtt 3611521 aacagcgcta atacaagcaa cggttttaat gctctgaaca agaagatcac catccttcct 3611581 attgatgtaa taaatctgaa gtgcatactt cctcaaaatc ttttctctac tttgttatgc 3611641 tatcaaaaac ttcacttatt agctttattt ttttataaac ttcatcccat tttcgcttaa 3611701 atgtcataaa atcgacaaaa attgctccaa ctttattcac atctatcgct taagatgaaa 3611761 agtttctagt tatttccgca tataaagtaa agaaagatga tgaagaacta attctgacaa 3611821 attaaggttt accacaataa aaaacttagg tcaatcaaaa atttcatttt gttaaacttt 3611881 ctagatagga attatttttt cctcgtctag catcttttca cacggttacc attttaacgc 3611941 atcaaatatt gaaagaaaag gcgcaatgaa gagccaatat gctctgaatt gtccgtattt 3612001 ttttatgaga gcatccagtt gtttatctta tacaaaaaag aggaatgata taagcaaata 3612061 aataaaaaat aggatgtgtt gcatgatgag ttttcttatt tcacttatcg tcgctattat 3612121 tatcggatgg cttggaagcc tgtttgtaaa aggagatatg cccggaggaa ttatcgggtc 3612181 tatgatcgca ggtcttatag gcgcctggat cggacacggg ctgcttggaa catgggggcc 3612241 gcacctagcc ggatttgcca ttattccagc ggtaatcggc gcagccattg ttgtctttct 3612301 agtaagcctg ttaaccagaa aaagaggata aaagcagcag cacccgaagc gtcagcgctt 3612361 tgggtgtttg ttttgccata aaaatcgaaa aagcctcaac cctagcggtt gaggcttttg 3612421 actggtttgg cgcccaactg atcgatgaac cttctgaagg cctgttttcc ctctgctgtc 3612481 tgcttaaata caccggcgtg ttcaaggatg cgcgcgaata catgtcccag ctcttctttt 3612541 atgactagat ctacgttctc ttttgttatg gttctttttt ccatcgtccg aagagcccac 3612601 tcactatgct ttgcagtgag cggattttgt tctaaggctg ttttcggatc agcagaacat 3612661 agcgccgctg ccgtttcttt catttcctcc tgtaagcggc caggcaatat cgccaatccc 3612721 atgacctcaa tcaggccgat attttctttt ttaatatggt ggacttcttg atgaggatga 3612781 aatattccta atggatgctc ctcatccgtc cggttgttcc tcagtacgat atcgagttcg 3612841 tacaagtctc ccctgcgccg cgcaatcggt gtgaccgtat tatggggcgt atcgcctgta 3612901 taggcggcaa tgccggcttt ttcatcggaa tacgtctgcc acgtgcggaa gatatggtca 3612961 gcagcttcgg cgacatgacc cggttcgtct ccttggagcc tgagcacaga catcggccac 3613021 ttcactaagc ccagcgacac gccgggataa tcatttaatt cataaacgtc ttccgcttct 3613081 gcacgtgcca ttggaaaatc atgcgcgccg ccttggaaat gatcatggct taggatgctg 3613141 ccgccgacaa tcggcagatc cgcgtttgaa ccgataaaat aatgcggata ttggccaaga 3613201 aatgacagca gcctttcaaa tgtttttttg ctgatctcca tcggttcatg ttcacctttt 3613261 aagacaatgc agtgctccgg ataatagaca tatggcgaga attgcaggaa ccattgttcg 3613321 tcctcaagga tgaccggaat gattctgtga ttttgccggg ctggatgatt cacgcttccc 3613381 tcgaagccga cattttcttt acacagcaaa cacatcggat aatttgtctg ttcctgctct 3613441 tttgcagccg caatcgcttt cgggtccttt tcaggctttg ataggttaat ggtcatttcc 3613501 agctcgccat attcggtcgg caccgtccaa tgaacatttt tggcgattct gtcagtccgt 3613561 atataataga catcctctga atattgatag aattcctttg tcgcctgttt tgggccgtat 3613621 aatgcttttg tctcttcaaa tttgcgaatg acctcggacg gggcaggcac aaaacagccc 3613681 atcagctttg cgctgagcag gtcacggtac gtatctgtat ccgcttccat tcggccggtt 3613741 tcggcagccc atttatagat gggagctagc aagtccggca ggctttgtga ctgcttgatg 3613801 ctggtgctgg agttcggctc gggatgtgtg atgcccagcg cttcataaag acggtttctc 3613861 gtatattccc gatcccagat cgaaatcaat tttcgttcca ggccatactc aagcagctgt 3613921 tccagatgtt caataatact catatgtcac tcccccttta gttctctcgc tccctctccg 3613981 atatccgcga cataaaagtc cgctcggagc cctgtttttt cttgatatct gtctccaacc 3614041 ttctgaataa aatcatcaac gaactcatct tttacaatgc tgatggtgca gccgccaaag 3614101 cctgctcccg tcattcttga tccaattaca ccttcgtgat cccatgccgc aaacacaagc 3614161 tcatcaagtt cagggcatgt tacttcatag tcatccttca atgaaaggtg ggattccttc 3614221 attaactgcc cgatttcatc tatattgttc tctttgaaca tatgggccgt cttaatagca 3614281 cgatgatttt cgtatacagc gtgctttgcc cggcgtctgt tcgtttcatt ttggatcagg 3614341 ctggaatgcg catcgaaatc agaaggcttg atgtcgccca gtgcggcaat atcgaggcct 3614401 tttttcagat caagcaatgc atcattgcat tcttggcgtc tcgtattata gctggagtca 3614461 gccaatgtcc tttttttgtt cgtgttcgcg atgaccagcg cgaggcctga gacattgagt 3614521 ttgctatatt catagtcaag cgtgtcacag ttcagcagca tcgcatgatg ttttttcccc 3614581 attccaattg caaattggtc cataattccg caattgacgc cgataaaatg gttttccgca 3614641 tgctgcgcca ttttcacaag ctcaagcgca tctacttcag gatgaaaata actttggagc 3614701 acgaccccca tcagcagttc aatagaagcg gaagacgaca gtcccgcccc gtttggaata 3614761 ttccctgaaa atacaatgtc aaagccatgg ggaactgcat atcccctctg ttgaaattca 3614821 taaatcacgc cttttgggta gttcgcccag tcgtcttctt tttgatagcg aatgtcgtca 3614881 aggctgcatt ccttgatgcc tgcgtttcta aagttatctg aatacatccg gacaagcccg 3614941 tcgtttcttt ctgcaacagc agcatatgta cccattgtca gcgcgcacgg aaagacatgc 3615001 ccgccgttat agtctgtatg ttctccaatc agattcactc ttccaggtgc gaaaaaaaac 3615061 cgtaacccct ctttttctcc gaatacactt gcaaatatcc cctttagctc ttcccgcatg 3615121 tgcaatcacc tttctggttt ttatttttta ttccccttat ttcttcatag aaaacggcag 3615181 atcatatgct gcagtcctct catacccctt cttcttttgt ttttttaaag acgagccatt 3615241 tgctcgcaac atagttgacg acaacaatga ccgcgttgtc gagtattttg gccaaggttt 3615301 catttgtatt gaactggccg acaagaatga tcatcatgcc taaatctatg ccgagagaca 3615361 ggacccgaac gctgaaaaaa gcagtgagct ctttcagcag gctctgcaga tcatgtgttt 3615421 tttgctgaaa cacatataat ttatttgtta tgtaagcaaa cagcacggac aaaatccaag 3615481 cggcaacagt ggcggctttg taatccacat tcatgatctc taccaatata taaaagctgg 3615541 cgatattcac aatggttgtg aaaaccccca taatgatata cataattatt tctctatact 3615601 tcactgatgt tcctcgcttt ctgaaaaact tttcaaaatt cttggcctct cgtgctctct 3615661 gtctaaagta aaaaataccg agagtgcgtc taaaaagctg cggaaggtgg ctggctggcc 3615721 caatacatat gattgtttga tgattccgtc gaggactgca catattattt tagccgtata 3615781 ttcaggatca atacaggcgt caatcagctt tctctccttc agccacttaa tatataacac 3615841 attttcttcc acccacaatt cgtacagccg gacataggcc ttgcatttct ttaagacttt 3615901 atatgtcggc atgttcatgg caaacgaggt gatgtcccac gacggcttat ttatgtaata 3615961 ggaataaagc agttctgcag cgtgttttgc agcctcgtcc aatgtcagcg atttcactga 3616021 ctcccgctcc atttgatcaa gataccctat aatgatcttt tttttcatct gacgtttttc 3616081 gagaaggtac agcagaaaat cgtccttgct gacaaaatga acataaaatg ctcctttgct 3616141 gtacccggcg gctctgctga tatcttctac agaaaccgga tcatacgctc ggtcaatcaa 3616201 caaattcacg ccagcgtcta taaaactttc aaatgttgct tctcttttaa tttgaaattt 3616261 gttttttttc atatttttct cctggcggta atgattaccc ttatcttaca ccggatcaat 3616321 ctttagcggt atttatttct ttaaacggtt atgctattcg gtttcccagg ggtcattttt 3616381 aataggctaa atgatttatt ttcatttaca tactatccag tcagtattta attgtttatt 3616441 attataaata aggtccattg gttatattag tcattttttt agggaatagg taggtggttt 3616501 ttccttcagt ttgtgaacac cgagcaacta tgtgtgaaat ttgttgtact cgcctccatc 3616561 atcgcgctgg cttgtctttt attgcccgca tgttgcagga aaacatttta tacaattgga 3616621 ggttactatg aaaactcatg ttaaaaaaga tttggacaaa ggttggcata tgttaattca 3616681 agaagctaga tccattggat taggcattca tgatgtgagg cagtttttag aatctgagac 3616741 agcatcaaga aagaaaaacc acaaaaaaac cgtccggcaa gactagtccg aacaggcgga 3616801 tctatttacc tctggctttt ctatcacctg atctgagttt tcaccatatc ctctattcaa 3616861 aagcaaatcg ctgcgctgag cttgaggaca aacggtgtgt cagctaacta cgacagacag 3616921 ccggtgatgc gatcacctct tggcacatgc attgtcataa agaggtgatg cgaacatgat 3616981 aaccgtgctc tggtaaacag cagctttgct gagaacaagc tgcattcggt gaggttttga 3617041 aagcaaactc gtttatacac ggccgagctt gaaaaccttc gcctgtcttt agaccactgt 3617101 gttcacctct tcacgacttc cttctttttt catcctccag ctattgtaca acgcataaat 3617161 cggactttca gtacatacct attggtgtac ctttttgctt acgtttagcg aataaaagga 3617221 ggaaagccat gtacaaagct gattataaac agattgctgc aacgccgtct tttcaagctt 3617281 ttttaaagca gaaacgcgct tttattgttc cttctgcgat tttctttttt gttttttatt 3617341 tttcactccc tgttttgaca tcttatttca cctttttgaa tgcaccggcc attggagctg 3617401 tttcatgggc ttggctgttc gccatcgccc aattcgctat gacctggata ctgagtactg 3617461 tgtattcccg gagagccgcc catttcgata agtatgtaag cgctttaaaa gaggatctga 3617521 agggtgaaca gacatgaata tgactgcttt tttattattt ttggcgattg ttggcctgac 3617581 gcttattatc acgtattttg ccgcgaagcg gacgaaaacg acgagtgagt tttatacggc 3617641 gggcggcggg ctcaccggcg ttcagaatgg actggcaatt gccggtgact acatgtctgc 3617701 cgcctcgttt ctcgggattg ccggaatgat tgcgttatat ggatttgatg gcttctttta 3617761 cagcatcggt tttctggtgg cttatctcgt tgtcttgtac atcgtggcgg agccgcttcg 3617821 gaatcttgga aagtacacga tggcagacat gattgccgct cgctttaaag aaaagaaaat 3617881 ccgcggtgtc gcggctctca ataccattgc catctctact ttttatatga tcgcccagct 3617941 cgtgggggcg ggcgcgctga tcaaactgct tctagggctg gattataccg cggctgtcct 3618001 catcgtcgga gtgctgatga ccatttatgt cgtgtttggc ggcatgatcg cgacaagctg 3618061 ggttcaaatt attaaagctg ttttgctgat ggccggcaca ctcgtgattt cgattatcgt 3618121 gttttcgaaa ttcggcttta gccttaatac catgtttgaa cagatgaaaa cggctactcc 3618181 gcttggcgct gattttttga accccggaaa taaatacaag gtgccgcttg agaccttgtc 3618241 gttaaacttg gcactcgtgc tgggaaccgc cgggcttccg catatattga tccggtttta 3618301 taccgttaag gatgccaaga cggcccgtac atccgttgtg tcagcgacat ggattatcgg 3618361 tgtgttttac attatgacgg tatttctcgg ctttggtgcc gcggcatttg tcggttttga 3618421 cgcgattacg gcggctgatc aagcgggaaa tatggcggct ccgcttttag caaaagcgct 3618481 cggaggagac tttctgttcg cgtttgtatc agccatcgcc tttgccacca ttttggctgt 3618541 cgtgacaggg ttggtgctgt ctgccgcctc agcatttgcc catgatattt acagccagat 3618601 catcagaaag ggagaagcaa ctgaaaaaga acaaatgaaa gcggccagat gggcttctgt 3618661 cgccgtgtca gtgctctcga ttctccttgc gatttttgca caatccttaa atgtggcgtt 3618721 ccttgttgca ctcgcgtttg cggtagccgc cagcgcaaac cttccgctga ttgtgtttac 3618781 agtcttctgg aaacgattca atgcctcagg cgctttatgg ggcagcctga caggcctgat 3618841 cagcgcgctt gtgctggtat cgatgagccc tagtgtgtgg gacccggccg gaggtgctat 3618901 ttttaccggt gatccgctca ttccgctatc taatccagga attatttcca tcccgctcgg 3618961 ctttctcggc gcgtggctcg gaacggtgct gtcgtctgat aaaacaattg atgaagatac 3619021 gtttgcagaa attcaggtga aggcgcatac tggcgtccat atggaacagg aataaaaaaa 3619081 gctctcttta tcgagagctt tttccttact ttttcttctg ctcgtcagaa atcgcttttt 3619141 caaatacatc cttgccggca gcacccggaa ttacagtgtc accgataata aaggttggaa 3619201 cggctgtgat gtcagcctct tcataggcgt gcttcaaggc ttggcgctgc acgtcctgat 3619261 atgttcttgt ttccagtgct gatttgaatg atgcaccgtc taatcccact tcctcggcga 3619321 gcttcgtcaa gatgtcaata tcgccgatat tttggtcctc ctggaaaaat gcctgaaaga 3619381 cacgggtgtt gtattcatgt cctttattgt attccttcgc aaaatggaag ccttcaaacg 3619441 cgaggtctgt atacggatgg ggcgagacgt ttggaaaatt gatctcgact cctaatttct 3619501 ccgccattgg ctgaattgat gtctgccaca tgtactgttt agaaggatca ttgaccggat 3619561 caagctgagg agatgggctt gggcgcagtt caaacggcat ccactcgact tcaacatcct 3619621 ttccttttat cgcttcttca aaagcggctt ttccaacaaa acaaaatggg cagacgtaat 3619681 ctgaataaac tttaatgtgt actgtcatga taatctcctt tcatactaaa ttgattttaa 3619741 actgtaacaa ttaaagttac aactgttttt taataaagaa gccgatttag gcttctttca 3619801 gattgatgac aaaatcctaa aaagttttag gattttgtca tcctttcagc gtgattgaaa 3619861 acccttgaag tctaggaaag ccgagcattg gagcggagcg aatgctctaa ttcgtgagca 3619921 ccaacgcaca ggcttgacaa cgaatgcgag ggtttgtcga cacgctgaaa gaagcctgta 3619981 aaggcttctt ttatgattcc agcaaacgct gggcaatata ttctcctttt ttgcagccgc 3620041 ctgggcatgc gtataaagca gaaccgattg tttgtgtata ttcgtttaac gcatcctttg 3620101 ctgaaagagc cttcagcatc gggataaact gattgtcggg atttttttga aaactgataa 3620161 acaggagacc tgcatccata tagccggttt tcggatcaag tccttctgtg taagagaaag 3620221 ctcttcgcaa aatttgtttc ccagtagatt tcgctagact gacgtgtgaa ttagacggaa 3620281 tttgattcag cttcacggga tctgtttcct ttttctgccc aaaaggcgcc cccgagcttt 3620341 ttctgcggcc gaaggtatcc tcttggtcct tgagggaaga gcggtcccat acctcaagga 3620401 acattttgat tttccgaaaa gccatatagg tgccgcccgt catccagtca ggctcaccag 3620461 actgaatcca cacgatcgag ttcatcaacg tgtcatcctt cgtgctctgg ttgcctgttc 3620521 catctttaaa cccgaagagg ttgcgcggtg tttcaccatt ttttccaccg cttaaaaagc 3620581 ctttgttcac aaaacggacc tcacaagtgc cgaccgcttg atttagcagg ttacgcagcg 3620641 cgtgaaacgc cacttgctcg tcgtctgcac acacttgaat gcagatgtcc ccgcctccct 3620701 gcttttcatc caggttgtca ttgggcatcg ctggaagagc ggctaggtgc ttcggttttt 3620761 tgcttttcag tccgaagcgg tcctttccgt ctttttcaaa aaagccaggc ccgaatccga 3620821 atgtgaccgt taagttggaa ggggataaat cagcagactc acctgtatcc tgcggcggca 3620881 gatactgatt tctctgctcc gctgacattt tcttgccaga cgtcagcatc tgtgtgagac 3620941 ttgtccagtt tctaaataac gtaatgatgt cgcttttgtc ttttgctgtt acatccagtg 3621001 cagcaaaata gacatacgtc tgatgggcag ttgtgattcc ggcctgatgc tttccgtaaa 3621061 acggaacaat ctgctcctcc tctttttcat cctttttcga tggcttagcc gcagtctgaa 3621121 caagcggagc gagaccgccg agaccgctgg caccgatcgc aacggctgcc cccgccatcg 3621181 ctccccattt taaaatgtcc cgtctgtgaa tttgttctgg ctttttctgt tcatcgctca 3621241 tgatgttaca aaactccttt tatagcacat tcgcaatctt cgacatggtt tcagaaagag 3621301 tcgtcagctt agtgctcagc tctctgattt gcttttcact taatttatca taagacgtat 3621361 aggactgatc atttgttttg tattttgcca ttaaaacttc aaattcgctg aactccgtat 3621421 ccagtttttc cgtcaagtcg gagtgatctt ttacaagcgc gcttttcact gtttgataaa 3621481 cggcttcgga gccttccaca tttgccataa ggtcaactaa atcaattcgt gagtagcgct 3621541 cttcttctcc cgtgattttc gaaattccgg cttcgttcag aagctccatc gcgcctgcaa 3621601 caatttgttc aggtgttaat ttcagtgatt gaattgaacc gtcaagctct tttacatcct 3621661 tgagaagctg gtcagctgtt gccttttccc cggaaatatc ttgatccttc caaatggcct 3621721 tctcaagctt atggaagcct gtccatttgt ctccttcttc aacatcgttt tctcgtgcgt 3621781 caattttcgg atcaagatct ccgaggcttt cagcgatcgg ttcgattcgc tcgtaataaa 3621841 cacgcgcttt cgcatataac gttttggact tttcgatatc gccggatttc acagcacccg 3621901 taaatgcttc agtcgctttg acaagctggt cactctgctc tttgacatag cctttatact 3621961 catccgctgc ttttgccagc tgatcgctag cctttttgcc gctcttcttc gcttctgtca 3622021 ggtcttctaa ggatgctttc aatgactcgg attctgtctt gatttttcct gcatccggtt 3622081 tgtctttttg cgcttctgtg tagattggct gaagatgctt ttcgatttct gtatattcga 3622141 atggatagtc gctgcgaata tcgttttcaa aggaaagcca gtagctgttt aactctttcc 3622201 ccttcttttc aatctctttt tggtctcctt tttccactga gtcattcagc ttagaaatga 3622261 tggtttccat tttatttacg gatgcggtga tttctttagt gaccccgctt ttttcagatg 3622321 aagctttttc tttggttgaa gatgtgtcat tggctccgca gcctgcgcac agcgcaagga 3622381 tgcatccggc tgatacagcg atttttgtga aattcatttt gtcagttcct ttccgtttgt 3622441 aaaatgtttt gccgcttctg aaacaagcgc aatcagtaaa aagagtaaaa tcaacatttg 3622501 cggaatcgtg ctgtacacag acggataaat tcctagcacc gatacagacg gcagccagct 3622561 ttctgcatca gacggaagaa tgcccgccag ttgaaggctg tgaacgccgg ttccgagaaa 3622621 tttcacgcac atatacagga caaccgccat tgatagaaga aaaaacggct tcaatggaat 3622681 gcgcattccg agcttgatca tcagaacacc gacgatgacg agaacgataa gccctgcggc 3622741 agttccgccg atcagttcag tgagcgggag cttcccgaca agcccgatga aaaagatgac 3622801 cgtttcgaga ccttctctta caactgccag aaatgcaatg agcgcaaagg aaagcaggct 3622861 tcgttttttt agtgcctgtg acttctggat attgattttt tctctccatt tatccattga 3622921 ggcgtttctg tgcagccaca ccccgacata caaaagcatg acagcggaca gtacgccggt 3622981 aacgccgcca agcaagaaat tgttttctcc gaatacactg gaggagaaca gaaccgtgac 3623041 accgatgccg gctgctaagg aaacagccat gccggcggac gccccgcccc agatccatgt 3623101 cgaggaacgc gtaacccgcg ctttttttgt catggttaat agcgctccga tgacaaggag 3623161 ggcctccatt ccttcacgaa ccgggatcag cgccgcatcc caccagctgt agctgcttga 3623221 agcgatcggc tcgagcaatt gaatcatttc gtcaatttgc tttgatacct tttcaggatg 3623281 gctgccgatc tccgccttca tcagcgccag attttcctcc gatgtcgtat aggcttcttt 3623341 cgattgggac acgacatctc cctcaacagc gagccaggat gtaactaaat tgtcgattgc 3623401 ggatgacgct tcatccaatt gttttttttc tatgaactgt tttgtgtctt tcaagctttg 3623461 tatataggct gttaaggacg cccttgattg acctgaggat gtctttttca gcacgacagc 3623521 ctgctgatag gtttctaaat gagacgcaag ctcttcaagc tgtgttttga gcttacgtgc 3623581 gtcttgattg ataaaagaaa gagaaatcat cgcgatattc gcgtccattt cactgtgaga 3623641 agaaaggttt tctttcttaa tagaaggttc ttcttttttc cacttcgcct tgaaggtgtc 3623701 aaacgtttgt tgtgccgaat ccatatcccc gtcttttacg gatttgatca tttgcttgtt 3623761 taattgaatt aatgcggcga tcggatcatc ttccgcatgt gccgcagaac cgaaaaccat 3623821 caacaagctg aatagaataa gtgccagccc ccgagccatc atgttcctcc tataattgaa 3623881 aatgattatc attgtataac ataatcatag ccagttcctg tcctttgtca attaaaattt 3623941 gaaggtctga aaaccttgat ggacagcaaa aaagctgtcc ttttacagaa cagccctttg 3624001 aaggaaaatg aacgattatc ttcctgtttt atacgtttga atttcctcac gaaacttgcg 3624061 tgcagcactc tcaggatcct ccgcctgact gatggcgctg atcatactga cgccatcggc 3624121 ccccgcttgg ataacaggtg cggcattatc tattgtgatt ccgccgatgc cgacaattgg 3624181 aatgctgatg ccttggcggc gcactgcttc gataagagat acaccctgta ccgctctcgt 3624241 atcttttttc gtttcagtcg gatagatcgg cccaagcccg acataatccg ctccgtcttc 3624301 ttcggcttgc ttcacctcag acatcgtatg ggcagaaacg ccgagaatca tatcacctat 3624361 ggcagctctt acctctttcg catttgcgtc ttcctggccg atgtggatac catcagcttt 3624421 cagattcaga gccaattcca catcatcatt gacaatgaac ggaacaccag cttcacggca 3624481 agctgcctgc gctttttcag caaatttaat ccgagcctct cctgtcagcg catccccgcc 3624541 tttttcacgg aactggtaca gggtggcacc gccttttaac gctttttgta caactgtaac 3624601 aggatcggct ttcgtattgt ttgaccccat aatgaagtat acagataata actctttcat 3624661 catttcccga gaaatacgag tcatgagaca gtcacccttt ctatagtcgc ccattcttgg 3624721 acgtcttgtt cagtaacagt tgaaagcttg ttcagcaatt caatctgaaa gcttccaggg 3624781 cctttgtcag ccgtctgctg tgcggcaagc tgagcggcga ccccatacga agaaatggcc 3624841 gcaatagcag caaacaatgg attttcttcc acagcgcaaa acgcaccgac gacggaagtc 3624901 agcaggcaac cggcgcctgt cacttttgtc agcagcttgt ggccgttatg aagggtgtat 3624961 acatgtgacg tgtcggctat gacatcaact tcaccagtta tcgcaatgac cgtgtttagc 3625021 ttttgtgccg cctgctgagc cagccggatg atgtcgcctc caccttcacc cgcatcaaca 3625081 cctttgatca gccaatcggt cacgccgacg gtatgggcaa tttccgccgc atttcctctg 3625141 attgcagcaa ggcgcacctc acgaatgatg tcacgtgccg attcagtgcg gaacggtgtt 3625201 gctccggcac cgacaggatc aagaatgacg ggaacgccat gttcattagc tgattttccc 3625261 gcgatgatca tcgcttcgac tgactccttg ctcagtgttc cgatatttaa aacgagtgca 3625321 cccgcaattt tcgccatatc ggcgacctct tcttttgcgt acgccataac gggcgatgcg 3625381 ccgagcgcga gcaggccgtt tgctgtgaaa ttcgttacga cattgttggt tatgctatgc 3625441 accagtgggc tatgccggcg gacagccgta agacattttg ctgctgattg tgcatccata 3625501 tttgcatcat cctttactat cttttttcgg gtcccataaa tacgatttcg tatgttcgag 3625561 ccaagctctg gcggcaaacg acaagtacct gtcctttctc caaataatgg cgaggtgcca 3625621 agggatgacc ggatcgacaa gcggaatgac tttcactttt tccgggtcaa ggccgcggca 3625681 gatccgttcc ggcaaaagcc cgatcccaag gttggcggat accatctcac taataaaatc 3625741 ccattgtgat gtttcataaa tgatatgggg ccggaaccca gccttgatac attccgtcat 3625801 aattcggttg tgcaggacaa aatcctctct gaagaaaata aaaggctcgt ccttcaactc 3625861 acgcagctga cattctttct catcagccag ccggtgggaa gggtgaacga caagcattaa 3625921 ggtttctttt acgattgtaa acgaatgaaa gatatcttcg tttgcgggaa ggaccacaac 3625981 gccgatatca agagagccgt ccccgacacc ttcttggact tttatagaac cgtcttcgac 3626041 tagctgaaag gtgacattcg gatagttttc acggaaatcg ccgagcactc tggggaaaaa 3626101 ccccgatccg atcatcggcg gcagtccaat ccgtacgtgc cctttcttga cttccataat 3626161 atcatttaat tctgacgtca ggttttgaaa tgatttaatg atttcctgcg cctgcacata 3626221 catgctatga ccggcatcag tcagttccac ctgcctgccg tttcggtaaa acagttcaat 3626281 tccgagctct tcttctaaat ttttgatcat ttttgatatc gtcggctgag aaacataaag 3626341 ggattgggaa gccttcgtaa aactttttaa acgggcgact tccaagaaat atgttaaatg 3626401 gcggatatcc atgcgcttca ccctttctat agacaaaagg aatacttctt attcttaata 3626461 tatattttac ctatagagag accttatgta caataagtat ataagggagg catcaatatg 3626521 aaaaaactgt tgctaaccgt tattcaaatc gctctgttat ttatatttgc tcggctgatt 3626581 aattgggtga cagcccttct tcatataaat attcccggca gtataatagg gattgtgatt 3626641 cttttcacat tattgcactt taacattatc aagcttgaat ggatcgagct tggtgcagcg 3626701 tggcttctcg gggagctgct tttatttttt atcccgtctg ccgtcggagt gattgaatac 3626761 ggagacatta tgtcgaaatt tggtgtcagc attctgcttg ttgtcatcat cagcacgttt 3626821 gtcgtgatgg tgtctacagg aacgcttaca caactcatcg caaagagaaa ggagaaaaag 3626881 catacgtgtt catcggaatt gtaagtttgt ttttaacggt tttggtgtat ttaggagcaa 3626941 aaaaggtata tcaacgcttt ccgcgtgttt atacgtcgcc gctattggtg acgcccgctg 3627001 tattagtcgg tctgctgctg ctggtgaatg tcccgtacga gtcctataat ctcggcggcg 3627061 gattgctgac cgatatgcta cagccggcca ccgtggcatt cgcgatcccg ttatataaat 3627121 atttccctgt tttaaagaaa tacgcagtgg aaattatttt gaatgtggcc gtcggttcat 3627181 gcatcgcgat tatttctacc gctcttattg cgaaatggct tcacctcggc accggcttaa 3627241 ttgacagcct cgtcccaaga tcagtgacaa cgccgatcgc gatgaacgta tctgaaatga 3627301 tcggcggtat gcctgccgtc acagccgtgt ttgtgatttt aaccgctttg ctcggcacag 3627361 tgatcggccc gatggtcatc cgttatttcc gcattgataa cgaaattgcg cggggcgtgc 3627421 tgcttggcac aagcgcgcac ggagcgggaa cgtcaaaggc atttgagctc agctctgtgt 3627481 ccggcacgat ttccagcgtg tcgatgatct tagctgcgat tatgacgctt tgcgcggcgc 3627541 cgtttttgct ttcatttatg taaaaaactg tcctctcgag ggcagttttt tttatgtgct 3627601 tccccttatt gaaaagctgg cgaattccaa tataatgtat ttgtggatac caaaggaggc 3627661 accctgatgc acaacttgca ggtgaggcgg cattatgccg cgttaaaagg attttatttg 3627721 tttgcttttc tcggtacggg cagcataatt cccttactca gtatgtattt aacgaaggaa 3627781 cagcatttaa gcggatcaca ggtcggcttg atcatgtcac tgggcccgat tgtgatgatt 3627841 ttctttcagc cgttttgggg catgctgagc gactatacgc aaaaaacgaa aggcctgctg 3627901 gcggtttgca catcaatcac aggcatcatt ggattagcct atattgcatt tgacagtttc 3627961 cctctgttta ttttgattgc ggcctgtttt gcagcctttc aaagcacgat tattccactt 3628021 tcggacagca tttcactaag gtacacacaa gaaacaaacg gcaactacgg cggaatccgc 3628081 ctgtttggtt ctctcggctt cggtgtcgcg gtgtttgcca tgggacaggt gacgaaccag 3628141 ctgtacccca ttcacgtgat ctttatcttt ggctgtgcct ttctgtgcat tgctgccata 3628201 ttggcttcac aagtgcccgg ccagcagaaa acaacaaagg tcaatatccg caaaggattc 3628261 cgggagctta tcagcaacaa aactttcctc atctttatga tcatcacctt tacgacattt 3628321 gctccaaact tagcgaacaa tacgtatttc agtctttttc tggacaaaag cggcgcgtca 3628381 ctttccgcta tcggcatttt atttttcatc ggtgtcattt cagaaattcc atttatgaga 3628441 ttcgcccaaa catttataga taaaatgggg ctgctcaacg tcattatgct gtcaggcgga 3628501 gtctcattat tcaggtgggc gctctatttc acggcgcctt cactatggat catttatgcg 3628561 acggtctttc ttcagggagt ggccatcggt ttatttatcc cggcggcgct tcaatatgtg 3628621 aaaaagatta ccccaagaca cgttgaagcg acggcgctga ccatgtacgc cgccattggc 3628681 aacgggttcg gcaactggtt ctgcacattt gcaggcgggt acatttttga ctacgtgtcg 3628741 atcttcgcag tctacttgct ttttggcatt ctgagcatag caggctttgg cctgacatta 3628801 tatttaatga aggctgaaaa aaacaaacat acacttcatc agccggctgt tacttttaaa 3628861 ccataatgac tataatgaac aaaagaaagg atgtgcgtta tgaacgggca agagcgaaac 3628921 agcatttcga aagggttgca ggttgatatt gtattgaaag cagatcaaaa aacaggaaaa 3628981 ctgacgagag ggacagtgaa ggatattttg acgaaatcaa actttcatcc gcatggcatt 3629041 aaagtccgtc ttgaagatgg ccgcatcggc cgcgaccagc agatcgtttc tacataaaaa 3629101 aaagctgccc ctgaacaggg cagctttttc atttattttt tctgcagaag gaccactttc 3629161 aggtagttgc cttccggaaa tgccgaaatc gttttgaaat cctccggcag cgtaaattcc 3629221 tcaatgatcg tgtagcgttc atttgtttct ttaaaggcgg catcaataaa gcctttgaac 3629281 ttcttcatgc caaaggcgct gctgtttgta gaggcaacaa tgacaccctt gtcagcagtg 3629341 atggcgatcg tttccttcag caggttttta taatccttgg ccgcgctgaa ggtgcgtttt 3629401 tttgtgcgcg caaaggaagg cggatctaga ataatcagat caaagcgcaa atcctttttt 3629461 gcagcatatg aaaaatagtt aaaaacgtcc atcactttaa tgtcgtgcgc ttcgtaatcc 3629521 agcttgttca cgctgaattg ctcgatcgtt ttggcaagac ttcgatttgc cacgtcgacg 3629581 cttgttgttt tctccgctcc gccaagcgcc gccgccacgg agaatgcacc cgtataagaa 3629641 aacgtattta aaacggtttt cccttttgca tagcggtctc tgatcgcctt gcgcacatgt 3629701 ctctgatcca aaaagatgcc cgtcatggcg ccttcattca gatccaccgc gtattgaatg 3629761 ccattctctt ggatgatgat cgggaactcg ccccttctcc ctttcacgaa gtcatcatct 3629821 tcaacgtatt gtccagccgt gtcgaagcgt ttcttctcgt aaatcgcttt ataatcaaga 3629881 tccatctcat ccaatgcgga aatcagcatg tctttaaagg tgtaaattcc cttgctgtac 3629941 cattgaatca gcaggtagcc gtcataatag tcgatggtga cgccgccgac accgtcaccc 3630001 tcaccgttga acaggcggaa agctgttgta tcttgagcct caaatagttt ggcgcgcgct 3630061 tgggccgctt ttgttaattt gctgagaaaa aatgcttggt caatctgttc atgtttattg 3630121 cgggtaagcg tccagccaac ccctttgttt tgcaggccgt aatagccccg cgcgagaaac 3630181 tcgccgccgc tctcagacac gatatcaacg aggtctcctt ctttcatgtg ccccgcactc 3630241 cctgcgagag cttctttttc aataagggga tagccttttt ttattttggc agcgtgtgct 3630301 ttttttaggg tgagtagctt catatatgtc gtcctctttc cgtttgcttt ctcttatggt 3630361 accacaaaac gccaagatgt ctgcattgac agaaaggaaa ggtttttcta cgatagacaa 3630421 aaagagttac gaggaggagc agcatggcaa aacgaattga ccatacaggc atcatggtaa 3630481 gagatattaa cgcgtccatc acattttatg aagaggtact aggcatgaaa ttgaaggatc 3630541 gcatcactca cacgaacggt gtaatcgagc ttgcttttct tggctttgaa gacggcccgg 3630601 aaacagaaat tgaactgatt caaggctaca gcagcgagct tcccgctgaa ggaaaagtgc 3630661 accacattgc cctgctgacg gatgacatcg cggctgaata tacaaaagcg gaaaaaatga 3630721 acgcaaaatt tatcgacgag gagatcacaa cacttccaaa cggataccgt tatttctata 3630781 tcgaaggccc tgacggtgag tggattgagt tctttcagcg gtaaaaataa agaacgtaca 3630841 ttttgtgatg tacgttcttt tttatctata ccaactgata tacgttgact catcgcaaat 3630901 catagcttcc cagcccatac gctcaaccaa ttcatggatg tttttatctt tggctaaaaa 3630961 gacattaatg aatgagtcat atacactcat aaacacaaaa tccattttct catcagttaa 3631021 aacgagctct gttgcggctt catcaagaac cgtccgcaag ttggcttcag ttatgtccaa 3631081 aacgccgcgg ttttccacaa tcggttctgc gtaataaaac cgattggatc cgttcgcacc 3631141 taataccttt accaaactcg gaatatgaaa atttgaaata tgatcctcac tgggataata 3631201 gaggtctcca tttatgtttt catgtaacac ctcagccaaa tcctctctcg cgaactcgtc 3631261 ccttaaagcg cctatcgacg tcattaaagc cagcgccagc tcagcatgtg tttgaaagcc 3631321 gcaagaagac ataaccttct tccaggaaac agccttgcct attcctctta tttcattatc 3631381 gtttggataa atatgttcat aatcattttt tctttttgca ttctcccatc cttcaggcat 3631441 ttggataaaa ggagaaaaga taagagcagc agatgagtat tcaactggta cttgttgtaa 3631501 gattggtgat tcgtcatcta accatatata atctagcatg cgcacctcct ttacatattc 3631561 taacattcct ttcgtttgaa agagatgatc agccctatga caggctgatc atctatcaca 3631621 tcacattttt atccccagat tcaaccgcac tctcttcccg ccatttttga tgatcccata 3631681 ttctgaaaaa cggatagtag atagcacagg tgatcagcag atttaccagc tgcataactg 3631741 cgcccgacac ctttccgcct gtcgccaggt aacctgatat gagcggcggc atcgtccatg 3631801 gcaccgcgat tccggccggt cttgccacca gcccggtgct catgccgata taagtcgcgg 3631861 taatcgtgag gagcggtgcg atgataaatg ggacaataag gaggggattc atgacaatcg 3631921 gcatgccgaa aatgatcggc tcgttgatat taaatagcgc agggccgatt cctaatcgtc 3631981 caagctgctt catttgtttg ctgcgggagc gcacaagcat cgtcaggaca agcgccagcg 3632041 tcgccccgct tccgccgaca ttgatccaaa tttgaaaaaa ctgagtcgta aaaatactcg 3632101 gcagcgcctc gcctgcttgg aaggcgagac ggttggcatc catcgcgccg taccaaatcg 3632161 gcgccatgat tccgccaatg atggaagccc cgtgaatccc gcacgaccaa agcagcatct 3632221 gcacaaattc agcgatcagg cttccgccga gactgccgcc aaggatggaa agcggtgtgc 3632281 caagcaggtc tcctacgaca ttgtgcagac tctgaaaagg tgtcatttca atcagaagac 3632341 gcgccagcca tacgagaagc acaatgataa agccgggaat cagcgcgaca aatgatttgc 3632401 ttaccgcagg cggcacaccg tctggcattt tgaagacgat atttttttga ataatgtacc 3632461 gatagatttc ggttgaaaac aaggcgatca gcatggcgac aaataagccc ttgctgccga 3632521 gcagcgtgat cgggattccg ccccctacca tgatggactc cgttgagcca tgcggtgtaa 3632581 acggcacctc aaacggtgtt gccagcagaa atgcggcaat tgaaatcgct ccggcagaaa 3632641 gggcatcgac accatagctt tctgccagcc gataggcgat cccaaaagcg gcaatcatcg 3632701 ccataatatc aaacgaagcg ttaacaggat atccgagctt atcggcccac tcgttcccaa 3632761 acacactcgc catgaaatca gcataccccg gaatcggcaa gctcgttaaa atcaagaaga 3632821 cagacccgat aataatcagc ggcatggtca ggataattcc gtcacgcaaa gcgctgagat 3632881 gccgctgccc ggcaattttc ccggcgacag gcattatttt ttcctccatc acccgagtga 3632941 atgtgctcat cttaaaaacc cccttttctc attgctttgt gaacaacctc cgcaatgttt 3633001 tctttatctt attttgaaaa cgcttacaaa ttcatttgga aaatttcctc ttcatgcgga 3633061 aaaaatctgc attttgctaa acaaccctgc ccatgaaaaa ttttttcctt cttactatta 3633121 atctctcttt ttttctccga tatatatatc aaacatcata gaaaaaggag atgaatcatg 3633181 aaaaacatgt cttgcaaact tgttgtatca gtcactctgt ttttcagttt tctcaccata 3633241 ggccctctcg ctcatgcgca aaacagcagc gagaaagagg ttattgtggt ttataaaaac 3633301 aaggccggaa aggaaaccat cctggacagt gatgctgatg ttgaacagca gtataagcat 3633361 cttcccgcgg tagcggtcac agcagaccag gagacagtaa aagaattaaa gcaggatcct 3633421 gatattttgt atgtagaaaa caacgtatca tttaccgcag cagacagcac ggatttcaaa 3633481 gtgctgtcag acggcactga cacctctgac aactttgagc aatggaacct tgagcccatt 3633541 caggtgaaac aggcttggaa ggcaggactg acaggaaaaa atatcaaaat tgccgtcatt 3633601 gacagcggga tctcccccca cgatgacctg tcgattgccg gcgggtattc agctgtcagt 3633661 tatacctctt cttacaaaga tgataacggc cacggaacac atgtcgcagg gattatcgga 3633721 gccaagcata acggctacgg aattgacggc atcgcaccgg aagcacaaat atacgcggtt 3633781 aaagcgcttg atcagaacgg ctcgggggat cttcaaagtc ttctccaagg aattgactgg 3633841 tcgatcgcaa acaggatgga catcgtcaat atgagccttg gcacgacgtc agacagcaaa 3633901 atccttcatg acgccgtgaa caaagcatat gaacaaggtg ttctgcttgt tgccgcaagc 3633961 ggtaacgacg gaaacggcaa gccagtgaat tatccggcgg catacagcag tgtcgttgcg 3634021 gtttcagcaa caaacgaaaa gaatcagctt gcctcctttt caacaactgg agatgaagtt 3634081 gaattttcag caccggggac aaacatcaca agcacttact taaaccagta ttatgcaacg 3634141 ggaagcggaa catcccaagc gacaccgcac gccgctgcca tgtttgcctt gttaaaacag 3634201 cgtgatcctg ccgagacaaa cgtccagctt cgcgaggaaa tgcggaaaaa catcgttgat 3634261 cttggtaccg caggccgcga tcagcaattt ggctacggct taatccagta taaagcacag 3634321 gcaacagatt cagcgtacgc ggcagcagag caagcggtga aaaaagcgga acaaacaaaa 3634381 gcacaaatcg atatcaacaa agcgcgagaa ctcatcagcc agctgccgaa ctccgacgcc 3634441 aaaactgccc tgcacaaaag actggataaa gtacagtcat acagaaatgt aaaagatgcg 3634501 aaagacaaag tcgcaaaggc agaaaaatat aaaacacagc aaaccgttga cacagcacaa 3634561 actgccatca acaagctgcc aaacggaaca gacaaaaaga accttcaaaa acgcttagac 3634621 caagtaaaac gatacatcgc gtcaaagcaa gcgaaagaca aagttgcgaa agcggaaaaa 3634681 agcaaaaaga aaacagatgt ggacagcgca caatcagcaa ttggcaagct gcctgcaagt 3634741 tcagaaaaaa cgtccctgca gaaacgcctt aacaaagtga agagcaccaa tttgaagacg 3634801 gcacagcaat ccgtatctgc ggctgaaaag aaatcaactg atgcaaatgc ggcaaaagca 3634861 caatcagccg tcaatcagct tcaagcaggc aaggacaaaa cggcattgca aaaacggtta 3634921 gacaaagtga agaaaaaggt ggcggcggct gaagcaaaaa aagtggaaac tgcaaaggca 3634981 aaagtgaaga aagcggaaaa agacaaaaca aagaaatcaa agacatccgc tcagtctgca 3635041 gtgaatcaat taaaagcatc caatgaaaaa acaaagctgc aaaaacggct gaacgccgtc 3635101 aaaccgaaaa agtaaccaaa aacctttaag atttgcattc caagtcttaa aggttttttt 3635161 cattctaaga acaccacaca caaccttttt cccatccatt gtacaggctt ttcatactat 3635221 tgctatacag ccatgaacag cataaaatga acgttattac agttatcacc acatatggcg 3635281 ggattgtgac tgggcaggca ggcaagaccc aatgatgcaa agggagtatt aatgcctaaa 3635341 aaacagggca ttttaactct tcttttcgtg ttgggctcat aacggcgcct tggacaaccc 3635401 cctattctca tgctccgtcg tcgacgcggg catttttgtc attttcagcc ggtatttctc 3635461 acttttttca ttttgattgt caacttttca tttgatacga tgaacaagcc gacttttctt 3635521 cagcaaagga ggttttaatt gcttgcataa agagattgca aaagaattac tgctgctcgc 3635581 aggaggaaaa aacaatatta tcagcatcag ccattgtacg acccgtcttc gttttgatgt 3635641 aaaggacgag acgaaaattg atatacatgc cattgagaac ctgcaaggtg tgcagggcac 3635701 ctttttccgc tatgggcttt tccagattat cttcggagca ggcgtcgtca acaaaatata 3635761 taaagaagtc gttcatgtat gggagaccgc gccttctgaa gagcctgtcc accagaaaaa 3635821 agccagccgg aagctgaacc ctgccgcagc ttttgcgaaa acactgtccg atatttttgt 3635881 gccgattatt ccggcaataa cagcaagcgg cctgctcatg gggctgatcg gcatgattaa 3635941 ggtgtttcat tggttcgctg ccggcagccc atggattaaa atgctcgacc tcgtgtccag 3636001 cacagccttt attttactgc cgattttagt cggcttcagt gctgcacggc aatttggcag 3636061 caacccatac ctaggggcag tgattgcagg gcttttgacg catcctgatc tgctggaccc 3636121 gtctatgctc ggcagcaaaa ccccgtcttc tttagacata tgggggcttc atatcccaat 3636181 gatgggctat cagggttcca tgataccgat tcttctttcc gtttttgtca tgagcaaaat 3636241 tgagaagcta ttaaaatcga ttgtgccgaa gtcgcttgat gtcgtgatca ttccctttat 3636301 tacggtcatg gtgacagggt gcctcgcgct gattgtgatg aatcccgccg cgtccatcat 3636361 cggccagatc atgacacaat cgatcgtcta tatttatgat cacgccggca ttgctgccgg 3636421 agctcttttc ggcggcatct actccaccat cgtcctatct ggattgcatc atagctttta 3636481 tgcaattgag gcaacgctgc ttgctaatcc gcatgtcggt gtcaactttt tagtgccgat 3636541 atggtcgatg gcgaatgtgg cccaaggcgg agcggggctt gcggtattcc tcaaaacgaa 3636601 acaatcaagc ctgaagaaaa ttgcgctccc cgcttctctg accgcgtttt taggcattgt 3636661 tgagccgatt gtattcgggg taaatctcaa attgatccgt ccctttatcg gagcagccat 3636721 cggcggtgct attggcggag catacgtggt tgcggtacaa gttgtggcaa attcctacgg 3636781 actgacaggc attccgatga tttcaatcgt gctgccgttt ggcgccgcta attttgttca 3636841 ttatatgatc ggtttcttga tcgcagccgt ctctgctttt atagctacat tgtttctcgg 3636901 gtttaaagaa gagacagaat aactggattt attcgatttc attcataaaa cgggggatga 3636961 aaggacaaaa aagctatgaa aattaaaaga atcttaaatc ataatgctat cgtcgtaaag 3637021 gatcaaaatg aagagaagat tctcttgggt gcaggaattg cgtttaacaa aaagaagaat 3637081 gatattgtcg atccgtcaaa aatagaaaaa acctttatca gaaaagatac acctgactat 3637141 aagcagttcg aagagatttt agaaacattg cctgaagacc acattcagat ttctgagcaa 3637201 attatctctc atgccgaaaa agagctgaac atcaaaatca acgagcgcat tcatgtcgct 3637261 ttttcagacc atctttcttt tgcaattgaa cgcctgagca atgggatggt tatcaaaaat 3637321 ccgctgctga atgaaatcaa agtcctttat ccaaaggagt tccagatcgg cttatgggcc 3637381 agagcactga ttaaagataa actggggatt cacattcctg atgatgaaat cggcaatatc 3637441 gccatgcata tccacacagc aagaaacaat gccggcgata tgacacaaac gcttgatatt 3637501 acaacaatga tccgtgatat tatcgagatt atcgaaattc aactgtctat taatatcgtt 3637561 gaagatacca tctcttatga aaggctcgtg acccatctcc gctttgccat tcagcatatc 3637621 aaagcaggcg aatccattta cgagctggac gcagaaatga ttgacatcat taaagagaag 3637681 tttaaggatg ccttcctgtg tgccctaagc atcggcacct ttgtgaagaa ggaatacggc 3637741 tttgagtttc ctgaaaaaga attgtgctac atcgccatgc atattcagcg gttctaccaa 3637801 cggtcagtcg cacgctgaga caaacaaaaa acgcttttga tcatctcaaa agcgtttttt 3637861 tatctgattt attggttgat cgccggattc ccaatcgtat tccacttcgt ataggacatg 3637921 taatggaaat actcatcgcg atacggatgt tttgtattgg agttccaagg cttttctccg 3637981 ccgcagaagt gcacgattgc cgggttttct cttgtttcat tatattgctt ccgccctaac 3638041 agagtcgatg gggttttcag ctttaacatg atataggttt gagcgttcca gcgcggatga 3638101 agttcatacc actgatcata caagatcgca ttcagtgcat cttggtcatg cagcacaaga 3638161 aagtcttcgt ctgggtgttc attgataaag ttgatgactt tttctgtgat gttttgcttt 3638221 ctccaagact caaaatcaat aatcatgata cctgagttaa aatacttccc tgtatcagtg 3638281 acgttcattt ctttcaggcg ttcatgctgc cccgcatcct caacagcggc tacggtgtat 3638341 ggcgcaatgt ctaagtccca tagcttagaa atatcctcta ggacaagcgc atcacaatcg 3638401 atgtaaatca ttcgtttgat gctttcatcc ttaattaagt cgggaatcga aatgcggtaa 3638461 tacgcggctt ttgtaatatg gctgctctca accgcatgtt catacatgtt ggtatccact 3638521 tctaaaaact caatcggcac tccgaatttc aaagtggttt cttccagtct ttttttgtta 3638581 tcaggcttaa ttccgccatc aatgacgtat aattttacct ctctctcctg atccatgtta 3638641 gtcaataaag aaacgaacat cccacctaaa tgacgagcat aattatcatc tgcgcatgat 3638701 acgatatgca tgatttcatc tttcctcaat ggtattcatc tccctttttg ttgtacaagt 3638761 tacataccct ttttcaaaaa aataaacacg ttctccgaca tttttttaaa cagaatgtgt 3638821 gatacaacaa aaaaggtgtc attttttgaa gatgcgataa agccaataaa gaatgaaaaa 3638881 gcttgcgatt gtgatggctt cagccgagac gatataccac ggccatggcc cgagaacatc 3638941 taagagagag gaaccgcccg gttttttcgt caaatacata taattcgcgc caagccagcg 3639001 atcaatcaga aaaatacaga cgccgtacac attaacaagc aggactgtca cccataacga 3639061 gcgctggccc attctgtagg tgccaatcac agccatcagc agacaggata aaaacacaga 3639121 cccgtgagaa ataaaaaaga ggatatatcg gatatgcgga aatgaaaaca taccgaggtc 3639181 aggagtggca agagcctgaa tcgaactgcc gatgccgaca aaaaacaaaa acacaaacag 3639241 ctttctgctt tttgtcacta acataatagc tgacaaatac accgacaggt cactaagctg 3639301 gagaggcaat gaagtgcgca ccgaccacct gtccgtggcg accatccata tttgatagcc 3639361 gatttgcgaa ccaagcaaaa gaaacacaaa cagagaacgc aaaaaccggc tggccctcgg 3639421 ctgcttgacc tcatcttgga acaaaaacaa cagaatggcc aaaagggaga taatcgctaa 3639481 cgtcactaca tgctctgtcg aaaacagatg aaacggatca tgcttatagt cggattgaac 3639541 atatttttgc aaaactgcac ccccgttttc gggtttttgt ttattttggc gttgtttggg 3639601 ctttttttat tcaaccgata tatgggcttg aagttcacac cagactctgt taaaattcgt 3639661 ttcatagcta atgattctga taatttaagg caggcctaaa aaatggaacg ttcacatcaa 3639721 catcagcagc ttcggaagga agaacacgat acactttcta agctcaaaca aatgcccgtc 3639781 gagtcactca acctggaagc catttcgatc gctacgaatc tgtatcggtc tgcacaaagg 3639841 ctccgtgtca aaatggagac tgaggttctt tctacctata acctttcttg gaccgctttc 3639901 tccattcttt atgatctatg ggtatgggga gcgctcgaaa cgagaaaaat cgctgagctg 3639961 tcagggatat ctacagctac agcaagcaac gtgatcaaaa cgctcgaaaa aaagagtttt 3640021 tgccgtaaaa gcatcgacac aagagatcgg cgactcgtgt ttgtctcaat caccgattcc 3640081 ggcaaacaag cgatcgaaga actctacccg gagtttcaca aaggggaaac agagctcatt 3640141 gcgggaatga cgaaggacga acagaaaata ttgacagggc tgcttagaaa ggtagctgac 3640201 aatcttcata caacataagc tttgacggga atccagtagc ggtttgtctc cctgtttcag 3640261 agagccggcg gtaggtgcga gccggcgcac aggcaaacgt gaattacctc cccaagcttt 3640321 ctttgtgaac cttagtagca aagaacggga aaccgttatt cgaatgagcg gaagacaatg 3640381 tcttcaacca gggtggtacc gcgtgcattg agccacgtcc cttattggga tgggctcttt 3640441 tttgtgtttg taaaaaagga ggaaaaatga tgagaacatt tgagcagctc acagcgtcac 3640501 aacaaaaaga ggtagaaaga cagcttcagc tatacatgac aggcgcccac gaagtcatac 3640561 cgccggagga attaaaggca aagctcgtga aatcaatttc cacgggcacg ccgcttaaaa 3640621 ttaagctcgg attagatccg tctgcaccgg atgtacattt gggccatacg gttgtgttaa 3640681 ataagcttcg ccaatttcaa gaaaacggcc acattgtcca gctgttaatt ggggatttca 3640741 caggaaaaat tggtgatccg accggaaaat cggcagccag aaagcaactg actgatgaag 3640801 aagttcagca caatgccaaa acctactttg agcaattcgg aaaagtgctt gatccagaaa 3640861 aagtcgagct tcactataac tcaaaatggc tgaaaacatt gaatctagaa gatgtcattg 3640921 aattagcagg gaaaataacg gtagcccgcc tgatggagcg cgacgacttt gaagaacgca 3640981 tcgccatgca aaaaccaatc tcactgcatg aattctttta cccattgatg cagggctatg 3641041 attctgtcgt tctcgaaagt gatattgaat taggcggaac ggatcagcat ttcaatgtcc 3641101 tcatgggacg gcatttccaa gaacgataca acaaagaaaa acaagtcgtc atccttatgc 3641161 cgctcttgga aggcttggat ggcgtcgaga aaatgtcgaa gtcgaaacac aactacattg 3641221 gcattaacga acatccaaac gacatgtacg gaaaaacgat gtcactgccc gacagcctga 3641281 tgaaaaagta catccacttg gcgacagact tagagcttga agagaaaaaa cagctcgtaa 3641341 aagacttaga aaccggcgcc gttcatccgc gtgatgccaa aatgctttta gccagaacaa 3641401 tcgtccgaat gtatcacgga gagaaagcag cagaagctgc cgaacactcg tttaaaacag 3641461 tctttcagga aaacagcctg ccggaagata taccggccgt aaactggaaa ggcgaaaaaa 3641521 cgatagcgat gattgatctg ctcgtcaagc taaagctcct ctcttcgaag agcgaggcgc 3641581 gccgcatgat tcaaaacgga ggtgtacgca tcgacggaga gaaagtaaca gatgttcacg 3641641 ccaaagcaga gataagagag aatatgatca tccaagtcgg caaacgcaag tttttaaagc 3641701 tccaataatc tgatattccg aaacgcttat gacccttcat tcataagcgt ttttttgcag 3641761 gtataaagca ctgtcttttc aaaaacgctc tccatcttgc aggaaactcc tttagcatcc 3641821 cgaaatattc cccaaccata catttagggg aggtttattt ttgatgaaaa agcttttgac 3641881 tgtcatgacg atggctgttt taactgccgg cacactgctc ttgccggcac agagtgtcac 3641941 ccctgccgcg cacgctgtac aaatatcaaa tagcgagcgc gagcttccat tcaaagcaaa 3642001 acatgcgtac tctaccattt ctcagctaag tgaagcaatc ggccccagaa tagccggaac 3642061 tgcagctgaa aaaaagagtg ccctattgat cgcctcatca atgagaaaat taaagcttga 3642121 tgtgaaggtt caacgattca acattcctga ccggcttgag ggtacactgt cttcagcagg 3642181 acgcgatatt cttctccaag cggcgtcggg ctcagctccg actgaggaac aagggctgac 3642241 ggccccgctt tacaatgcgg gattgggcta tcaaaaggac tttaccgctg acgccaaggg 3642301 caaaatcgcc ttgatttcca gaggagacct gacttattac gagaaagcca aaaatgccga 3642361 agccgccgga gcgaaagctg tcatcattta taacaacaaa gaaagcctcg tgcctatgac 3642421 gccaaacctg tcgggaaata aagtcggcat tccggtcgtc ggcattaaga aagaagacgg 3642481 cgaagcactt acccagcaaa aagaagccac cttaaaacta aaagcattca caaaccaaac 3642541 ctcccagaat atcatcggaa tcaaaaaacc aaagaacatc aaacatccag acattgtgta 3642601 cgtgaccgcc cattacgaca gtgttccttt ttcgcccgga gcaaatgaca acggctcagg 3642661 tacctctgtt atgctggaga tggcgcgtgt cttaaaaagc gttccatctg ataaagaaat 3642721 ccgctttatc gctttcggcg ccgaagagct cggcctgctc ggctcctctc actatgtaga 3642781 tcatctatcg gaaaaagagc tgaaacgaag cgaagtgaac ttcaacttag atatggtagg 3642841 cacaagctgg gaaaaagcgt ctgagctgta tgtcaacaca ttggatggcc aatctaacta 3642901 tgtttgggaa tccagccgta cggctgctga aaaaattggg tttgacagcc tgtctctgac 3642961 acagggagga tcatctgatc atgtgccatt ccacgaagcc ggcattgatt ccgctaactt 3643021 tatttgggga gacccggaaa cagaagaagt tgagccgtgg tatcataccc ctgaagactc 3643081 gatcgaacat atcagcaaag aacgcctcca gcaagcaggc gatcttgtga cagccgctgt 3643141 ctatgaggct gtgaaaaaag agaagaaacc gaaaaccatt aagaaacaaa tgaaggcgaa 3643201 agcatctgac atttttgaag atatcaaata aaaaaagacg gcacttgggt gccgtctttt 3643261 ttaatccact tctttcttaa tccccagcat tttctcatct aggtaatggg caatctccgc 3643321 ggcttctttc agctcatctg ttaattgctt aggaacgtca ttgttcaatt tataataaat 3643381 tttatgttca aggctcgccc agaaatccat cgcgattgtc cggatttgaa tttctgcttt 3643441 gacgtattcc acacggttcg ttaaattcac aggcatctca atgattaaat gcaggcttcg 3643501 atagccattc ggtttgggtg tctggatata atcctttacc tttacgattc tcaaatcttc 3643561 atgctgcttc aacacattca cgacattata aatgtcagaa ataaaggaac agatgatgcg 3643621 cacgccggca atgtcgtgaa tatgctcctt catttccttc gtcgtaatct cacagccctt 3643681 tctcattaac ttattcacga tgctttcaaa gctttttaca cgggattttg tatgttcaat 3643741 cgggttgtgt ccgtgaatga ggttatattc ctggctgata attgagaact ttgtatcgag 3643801 cgcatctagc gcaaatttat aaactaataa ctcatttttc caatcttcca ttactgtttt 3643861 taaatcgtcc atatgtgtta cagataaatc catgttcgtc atctccttta acggaacttt 3643921 atccgctgtc catgtactag acgtccctgt ctgctgcaag gttctatgaa tttttttaca 3643981 aaatgcggtc gattgtaaca aaaaaagacc gcatgaaacg agcggtcttt tttattatcg 3644041 gaaatagctg atcaataatc cgatcgagag caggaatccg aaaaatgtat ttgtttgggc 3644101 tgttgatttc attgcgacaa tcatattcat cggcatttcg ttctggacga agcccttcac 3644161 tgcctgaacc ggcttaggca cgctcaaaaa gacgacaaac agccatgggc ttgcggcacc 3644221 ggtaataacc aagccgacaa cccagatata agcgacggca aacgacgcag ctaacagagt 3644281 aacagctccc ttatgcccca tcaaaatcgc caatgttttg cgtccgcctt ttttgtcctc 3644341 ttcaatatca cgaatgttgt tcgacaggtt aatcgcgccg acaagaatcg caatcgggat 3644401 ggaaatcaaa atgctctgca tattgatctt atctgtctga atgaaaaacg aaatcagcac 3644461 aaacaccgaa cccatgcaaa tgcctgagaa taattcaccg aacggcgtgt acgcaatcgg 3644521 cagcggcccg cctgtataca ggtagccgat cgccatgccg acaaggccga tcagcgcaag 3644581 ccaccagctg ctgctggcac aaatatagac accgagcaaa atggcaatcc cgtatgaggc 3644641 aagagctaat tgcaaaatcg ttttaggctt cattccgtgg cgtacaatgg cccctccgat 3644701 tccgactgat tctgctgtat ctaatccgcg tttaaaatca tagtattcat taaataagtt 3644761 cgtcgcgatc tggatccata ggcaagaaaa cagcatagcc aaaaacagca gcagatcaac 3644821 cttcacataa aacatcgcca aaacggttcc gagcagcaca ggcacaaacg atgcggttaa 3644881 cgtatgagga cgggttaact gccaaaggat ctgccccatg ctttcttttt gcggcgctgt 3644941 ctgaccctca cccttatttg tttggttcat cttcctcttc ctttctatta aaaggcttac 3645001 tttttttcag ccggcagctt aataaaaaac tccttttgct tccttatcta tcataatgac 3645061 ttctccctta tttcacaaga taccgcaaga aggcgttttc tttcttatta tacgcttctc 3645121 gccctgattt cattaggttt ctgctttcac ttgaacgaac aggtacagaa aaattttttt 3645181 aagtacatta cactttttaa aagttaaaaa gatcttttga ctccaggtat cttttccttt 3645241 attatgaatc agctcgaaac attccattct tgcccttgca ggtataaaga ttcattttca 3645301 aaaacatacg ccgatatatt aatttgaggg agattaggga aaaaatgaaa ctttttgagc 3645361 atctgatcgt caaataatca tgtgattgtc gaaaaaacgg gaagggaatt tttgatatgc 3645421 tgcaattaat gaaacagctg tatgaaaaac ccgctgtcaa gtggacatgt catacaggct 3645481 tttatttgat gatactgctt gttttgtttt ttatgtatgg ttttcacacc gcgaataccg 3645541 gttcatatat ttataacgat ttctaattgg agagagaata actatgaaac ttttacatgc 3645601 tattcaaaca catgcggaaa cttatccgca aaccgatgcc ttccgctctc aaggccagtc 3645661 gctcacgtat caggaattat gggagcagtc tgaccgcgcg gctgccgcga tccaaaaacg 3645721 catttctggg gaaaagaaat ctcctatcct tgtgtacggc cacatggagc cgcacatgat 3645781 cgtttccttc ttgggaagtg tcaaagcggg acatccttat attccggttg acctgtctat 3645841 tccgtccgaa cggattgcga aaattatcga aagctctgga gcagaattgc tgatccatgc 3645901 agcaggactc tcaattgatg cagtcggcca gcagattcag acagtttctg cggaagaact 3645961 gctggaaaac gaaggcggct ctgtcagcca agatcaatgg gtcaaagaac acgaaacgtt 3646021 ttatatcatt tacacttccg ggagcacagg aaatccgaaa ggcgtgcaga tttccgctgc 3646081 gaaccttcaa agcttcacag actggatttg tgcagacttt ccagtcagcg gaggaaaaat 3646141 atttttaaac caagcgccgt tctcatttga tttgtctgtc atggacctat atccgtgcct 3646201 tcaatcaggc gggactttac attgcgtgac aaaggatgct gtgaataagc cgaaagtctt 3646261 atttgaagag ctgaagaagt ccgggctgaa tgtgtggaca tcaacacctt cctttgtgca 3646321 aatgtgcctg atggatccgg gtttttcaca ggatctgctg cctcatgcgg acacatttat 3646381 gttttgcgga gaggttcttc cggtttctgt ggccaaagcg ctgcttgagc gttttccgaa 3646441 agcgaagatt tttaatacgt acggcccgac tgaagcgaca gtggctgtca catcggttga 3646501 aattacgaat gacgtcatca gccgcagcga atcgcttcca gtgggcttcg ccaaaccaga 3646561 tatgaacatt ttcattatgg atgaagaggg acagccgctt cctgagggag aaaaaggaga 3646621 aatcgtcatt gcagggccga gtgtaagccg aggctacctt ggtgagccag agctgacgga 3646681 aaaagcgttt ttctctcatg aaggccagtg ggcataccga actggcgatg ccggctttat 3646741 tcaagacggt cagattttct gccaaggacg tttggatttt cagattaaac ttcacggcta 3646801 tcgaatggag ctggaggaaa tcgagttcca tgtcagacag tcacagtacg ttcgttctgc 3646861 tgtcgtgatt ccttatcagc caaacggaac agttgagtat ctgatcgctg ctattgtgcc 3646921 tgaggagcat gagttcgaga aggaattcca gctgacaagc gctattaaaa aagagcttgc 3646981 cgcttctctt ccggcatata tgatcccgag aaaatttatc tatcaggatc acattcaaat 3647041 gacggctaac ggcaaaattg accgaaaacg cattggcgaa gaggttcttg tatgacgcct 3647101 tacagctcgt ttttattctt tatactgctt ggcattcttc ttctgccgac gatcattctc 3647161 ggcttaaacg gaaaaagatt tcaagcatac aacatgttca tatctatcat tatattggct 3647221 ttaatttttt cgcacgactt acacggggtc atcgcgctgt gcctgtttac aatatggcag 3647281 gtgctcctga tcagcggcta tctggcatac cggcagaaag cgaacagcgg ctttgtcttt 3647341 tgcggagctg ttatcgcgtc tattctgcct ttatttctgt caaaaatatg gccgtttctt 3647401 tcacacccgc agccgcatca tccgccgcat aacctgatca gctttttagg gatttcatat 3647461 ttaaccttta aaggcgttca gctgattatg gaagcaagag acggactgct gaaagaacag 3647521 ctgccattgc accgtctgct gtatttcatc ctgtttttcc cgacgatttc ctccggcccg 3647581 atcgacagat accgccggtt cgtcaaggat gaacagaagg cttggacgaa agaagaatac 3647641 gccgacctgc tgtatacggg aatccataaa atcttcatcg gtttcctgta taaatttatt 3647701 atcggctacg cgatcaatac gtacttcatc atgaatcttc ccgcaatcac gcacaataag 3647761 attcttggga acctgctgta catgtacggc tacagcatgt atttattctt tgatttcgcc 3647821 ggctacacga tgtttgccgt cggggtcagc tacattatgg gcattaaatc accagaaaac 3647881 tttaataaac cgtttatcag taaaaatatt aaagatttct ggaatcgctg gcatatgtct 3647941 ctgtcatttt ggttcagaga ttatgtgttt atgagattcg tattttggat gactaagaaa 3648001 aagtggatca aaaaccgtat ggccgtctca aacatcgggt atttcctgct gtttatgctg 3648061 atgggggttt ggcacgggct cgcgccgcaa tatatcattt acggcctcta tcacgccgtt 3648121 ctgatgacgt gttacaactt tttcgagaag tggaataaga aatataaatg gctgccgtcc 3648181 aaccgctgga caaccattct cgctattgtg atcacattcc atttcgtttg cttcgggttt 3648241 tatattttct caggaaaacc atttcatcac caccattaaa ggagattaga aagctatgga 3648301 ttttaaacaa gaggtattag acgttttagc agaggtttgc caggatgaca tcgtaaagga 3648361 aaatcctgat attgaaattt ttgaagaagg tttgcttgat tcttttggaa cagtagaatt 3648421 gctgcttgcg attgaaaacc gttttgatat tttagtgccg atcactgaat ttgaccggga 3648481 cgtttggaat acacctaaca acattgtaaa tcagctgtct gagttgaaat aatgaaaaag 3648541 cgttttttcg gtccaattat tttggcgttt attctattcg caggcgccat cgcaattcca 3648601 tcttcatggc tgacaggctt catcaccgat aagcgtgtga aagagtcagc aacagccttg 3648661 aatccgagta tgtttcaagg gctatattta caagatcaga tgctcaaaga tccgacatat 3648721 cttccgattt acgggtcttc tgagctttct cggctggacg agttccaccc atctaattat 3648781 tttcaggtaa acaatgaggg attcacgcca taccttgtcg gcaaaggcgg atcccagtca 3648841 ttgattcatt ctttaaactt cgctgcccac atggatcagc tgaagggcaa aaaaatcgta 3648901 ttcatcgtgt ctccgcaatg gtttattaag cgcgggtctg atgaacagca tttcgcgccg 3648961 aactattctg cgctgcaagg gcttgatttg gcatttaacg atcagatcga tcctgaaatt 3649021 aaaaagaaaa tgatgaaacg catgcttcgc tttaaggctg tgcaaaacga tgccattctt 3649081 tctgagctgt acaaagcaat ggtaaacggt cagacgtgga aagtgaacgc gctgaagccg 3649141 gcggcgaaag tgtattacag catgctggaa aagaaagatc tgtattattc aacgacagaa 3649201 tcatccgggc caaagcgcta tatctcgcag tcagtaaagg ataagtcatg gtctgaattg 3649261 aataaactag cggatcaatc gggcaaacgc cactccggtt ctaacgattt tcacatcgac 3649321 aaccctgtct ataaaaagct gaagccgaaa gtgcctaagc tgaaagggaa aaacaaagga 3649381 agatcgtatg cggtgtcacc ggaatatggc gactttgaaa tgatgctcga tatcctgaag 3649441 gatgcgggcg cagagcctat gtttgtcacc attcctgtta acgggaaatg gtacgattac 3649501 acgggcttcc cgaaaaaagg acgcactgac tattacaaaa aggtaaataa acaaatcaga 3649561 gcgaagggct tccaggttgc tgatttctca gggcatgaat atgacccgta tttcatgaaa 3649621 gacaccattc acatcggctg gaaaggctgg gtgtatgtcg ataaagcaat tgacgaattt 3649681 tataaaaccg gaaaagtcac ttcatcctga gcatctcata ggacgcggct gcatatttcc 3649741 tgctaagatt tgtaatagta aaggaatcac agccaactta attaagaggt gttacatcca 3649801 atgaagatga caaataatac ggttttaatc acagggggtt ctgctggcat cgggcttgaa 3649861 ctggccaagc gcctgctgga acttggcaat gaagttatca tttgcggacg cagcgaagca 3649921 cgtcttgcag aagcgaagca gcagctccca aacatccata caaagcaatg tgatgttgca 3649981 gaccgttcgc agcgggaagc attgtatgaa tgggctttaa aggaatatcc gaacttgaat 3650041 gttctcgtca acaacgccgg cattcaaaag gaaattgact ttaaaaaagg gacagaggag 3650101 ctttttgtgg acggtgatga aattgaactt aatttccaag cgcctgtcca tttatccgcc 3650161 cttttcacac ctcatttgat gaagcagccc gaggcggcaa tcgttcaggt cacatccggg 3650221 cttgcgttta acccgttagc tgtttatccg gtgtactgcg caacaaaagc ggcacttcac 3650281 tcgttctcgc ttacgctcag acaccagctc cgcgacacga gcgtggaagt gattgaaatg 3650341 gcaccgccta tggtggacac gggcttaaac caaaaatcac gcgataaaca aggcctgacg 3650401 taccggggca tttcatctga agaatatgtt caatatttct tggacggctt gaaggaaggc 3650461 aaacaggaga ttacaaatga acgtgttgaa ggtcttcggg atgccactcg cgccgattat 3650521 gacaggttat tcgagcaaat gaacacgcag gagaattaat ttctcctgct tttttcatat 3650581 gaatttctta caaatttgag caaacctatt gcgattattt gttgaaggta tacaatagaa 3650641 tataattatt ttcaaataag tttgataata taaacaattt aacagcaggg agattgacca 3650701 tgactaaaca aacaattcgc gttgaattga catcaacaaa aaaaccgaaa ccagacccaa 3650761 atcagctttc gttcggaaga gtgtttacag accacatgtt tgtaatggac tatgccgcag 3650821 ataaaggttg gtacgatcca agaatcattc cttatcaacc cttatcaatg gatccggctg 3650881 caatggtcta tcactacggc caaaccgtgt ttgaagggtt aaaggcttac gtgtcagagg 3650941 atgaccatgt tctgcttttc agaccggaaa aaaatatgga acgcctgaat caatcaaacg 3651001 accgcctctg catcccgcaa attgatgaag aacaggttct tgaaggctta aagcagcttg 3651061 tcgcaattga taaagactgg attccaaatg cggagggcac gtccctttac atccgtccgt 3651121 tcatcatcgc aaccgagcct ttccttggtg ttgcggcatc tcatacgtat aagctcttga 3651181 tcattctttc tccggtcggc tcttattaca aagaaggcat taagccggtc aaaatcgctg 3651241 ttgaaagtga atttgtccgt gcggtaaaag gcggaacagg aaatgccaaa accgcaggaa 3651301 actatgcttc aagcttaaaa gcgcagcagg tagccgaaga gaaaggattt tctcaagtac 3651361 tctggctgga cggcattgag aagaaataca tcgaagaagt cggaagcatg aacatcttct 3651421 tcaaaatcaa cggtgaaatc gtaacaccga tgctgaacgg gagcatcctg gaaggcatta 3651481 cgcgcaattc agtcatcgcc ttgcttaagc attggggcct tcaagtttca gaacgaaaaa 3651541 ttgcgatcga tgaggtcatc caagcccata aagacggcat cctggaagaa gccttcggaa 3651601 caggtacagc agctgttatt tccccagtcg gcgagctgat ctggcaggat gaaacacttt 3651661 cgatcaacaa cggtgaaaca ggagaaatcg caaaaaaact atatgacacg attacaggca 3651721 ttcaaaaagg cgctgtcgca gacgaattcg gatggacgac cgaagtcgca gcgctgactg 3651781 aaagcaagta agaaaaaagc cggcccatta caggccggct ttttttacgc ttcaattttg 3651841 ttgaaaaact gcggcagata cgctttgtgc gcctctagca tttcgtctaa aatctgtttg 3651901 gccacagtat cggacgggac aagcgggtta atcgtcatgg caaggagcgc agtttgatag 3651961 tcacctgtaa ctgccgcttc tgccgcgaca cgttcaaagg atttgatttg ctggacaagg 3652021 ccgcggacag acaccggcaa gtcgccgaca gcaattggct tagggccggt tttcgtcatc 3652081 acacagttca cttcaactgc ggaatcgtct ggaatactcg ctattgcacc attattgatc 3652141 gtgttcaccg gctgaatgtc atgtttatca ttataaatgg agctgattaa gttacatgct 3652201 gcatcactgt agtaagctcc gccccgtttt tccagctgcg gcggtttgat cgcaaggttt 3652261 ggatctttat aaagctcgaa cagctctttt tcgaccttct gtacgacttc agcgcgggtg 3652321 ccctccgttt gtgatgcttc cagttcgtgc tccagcatct cttttgtttt aaaatagtaa 3652381 cggtgatagc cgcaagggat gacattgagc gcttttaaga aatccggttc ccattcggcg 3652441 cctgagatat ttttcatcgt catcgcgttt ttcgggtcgc ccatcgcctc gatgacttgc 3652501 tccttcacac ttacgccgtc caagaaaaca tccagcccga ataccatatg gttcagtccg 3652561 gcaaattgga cttctacgcg gtccacatct acatcaagcg ctttggctac gcccattttg 3652621 atgccgattg gaacattgca aagaccgacg actttcttca ggttggagta gcgaagcaag 3652681 gcttctgtta ccatgccggc agggtttgtg aagttaacaa gccaagcgtt cgggcaaagc 3652741 tcttctatgt cctttgcgat ctcaaggatg accggaattg tgcgcaatcc tttaaacaga 3652801 cctcccgggc cgtttgtttc ctggcctatc actccgtatt ttagcggaat gcgctcatcc 3652861 tttgctcttg cctgcaaaag tccgacgcgg aattgggtcg tgacaaagtc tgcgtctttc 3652921 agcgcctttc tccggtcgag cgtaagatga atgtcaatcg ggacgccagc tttttcaacc 3652981 atccgtttgg cgagtgtgcc gacaatattc agcttttctt cgccctcggg gatatcgaca 3653041 agccataatt cacggacagg cagctcatca taccgtttaa tgaacccctc cactagctcg 3653101 ggcgtatagc ttgaacctcc gccaatcgtt acaatcttca atccttttgt catatgcttg 3653161 ctcccctttg ctcggtgatt ttttcatata actcaatgat ctctgcagcc atatccttca 3653221 ctgtcattgc attcattaaa tgatcctgtg catgaaccat cagaagcgtc atttccgtct 3653281 tttctccgcc cgcttcattt tggatcagct ctgtctgata atgatgggct tttgacaatt 3653341 cttcagcagc gtcttgaagc tttttccgcg cttcttctgc gtcaccgctt ttcgcagcgg 3653401 caatggcctc cattgcggag ctcctaccgt ttcctccgtg aaggatgatt tgaaaaatga 3653461 tttgttccat ttcctcattc acgcgattca cttcctttct ctacagagcc gcttctttgt 3653521 catctgttgc tgcaggcgtt tggaccagct ccagatcgtt ttcttctttc agcttctgct 3653581 tatcccacat tctgaagaat ggatagtaga caacaaagga cacggcaata ttaatggctt 3653641 gcatgaccgc gcctgagact tttcctcctg tcgccaagta gcctgaaaag atcggcggca 3653701 tggtccacgg cactgcgata cccgccggtt tggcgacaag gccggtgctc attccgatgt 3653761 acgtgagtgt cactgtgaca agcggcgtga tgataaacgg aagtaagagc attgggttca 3653821 tgacgatcgg cattccgaat ataatcggtt cgttaatatt gaagatggcc gggccgaccg 3653881 caagcttccc gagctgcttc atttgtttgc ttcgggcgcg caggaacatc gtgacaacca 3653941 gtgccaatgt ggcgccgctt ccgccaatat tgacccagat atcgaaaaat tgctgggtga 3654001 aaatcttagg aagctcctca ccggcttgga atgcgatccg gttggcatcc attgcgccgt 3654061 accaaatcgg tgccatgacg ccgccaacaa tgtttgcacc gtgaaggccg caggcccata 3654121 aaagcatttt gacggcttcg gcgacaaggc ttcctccaag gcttcctccc agaatggaaa 3654181 gcggagtccc caataaaacg cttacaatat tatgaaggct ttcaaacggt gtcgcttcaa 3654241 caatcagccg ggctgcccaa attaggaaga tgacggcaaa gccggggatt aacgcgacaa 3654301 atgacttgct taccgccggc gggacaccgt ccggcatttt gaagactaaa ttgcgctgga 3654361 taataaggcg gtaaatctct gtggacacca ttgcgataat catggcgaca aataagcctt 3654421 tgcttcccat gagcgaaagc ggaatcccgc cgccaaccat gatttctttc gtcgcgccat 3654481 ccggcataaa cggcacttga taaggtgttg ctaataaaaa tgccgcaagg gaaatggctc 3654541 cggccgacaa ggcatcaaca ccgtatttct cggcgagccg gtaggcaatg ccgaacgcgg 3654601 cgacaagacc cataatttca aaggtcgcgt cgactgggta ggccagtttt tcagaccagg 3654661 agctgccaaa cgtttttgcc ataaactcag cgtatcccgg gatcgggagg ttgccaatga 3654721 tgaggaaaaa ggaaccgatg ataatcaggg gcatcgtgag gatgatacca tcacgcagcg 3654781 cctgcaaatg acgctgtccc gcaattcttc ccgctatagg catgaccttt tcttctaaga 3654841 tctgattgac tttattcaca tagcccgccc ctctctatga cacatgtcca agctgttcag 3654901 ctgatttcag cacttccgcc ccattgcacg ttccataatg gacggtatta atgacgtcta 3654961 ccggaacccc ctttgactct cctaattttt tgagctgcgg aagcatgtaa cggacttgcg 3655021 gaccgagaag caatacatcc gctttatcga tatgattttg tacagaatcg cctgaaactg 3655081 cccaaatggt atagtctttt ccctgttcct gcgcactttt ttccatcttg ctcaccagta 3655141 agctagtaga catgcctgct gcacaaacga gtaatatatt catgtaaaag accccctaga 3655201 gtttgatcaa ttttgtaatg tcctgctgtt gctatcatca tattatgaaa tcgctttcat 3655261 aaacactcag ggtttttccg caggcaacgg aaaaaaggta tatacaggct gtcagctcag 3655321 cattttttgg tcaaacacat ccgaaagctc ttgatatgaa cggcatttga tcagctggtt 3655381 catcgccgcc gggtcatcca aaatgctgcc aagcagttta tacatgcttt gtaaatccgc 3655441 tttgttctcc ttttcgacac aaagcagaca gacaaattga actcgctgac tctcccaatc 3655501 gatcggtttt ttgagcgtac aaacggccca aaacgttgtt ttcgtctgcg gaacaagcgg 3655561 gtgcgggatg gcaacaagat tgccaaaaca cgttggcgac atgtcttctc tttcaaaaat 3655621 ggaatctatg atttcttcat cggcaaagcc gcattcgacc actttctgcc ctaaaaattg 3655681 aatcacttct tcttttgagc gcagatcctc ctgaaaaaaa acgagttctt tttttaggta 3655741 gcgattggct ttttcctttt catcactcag aatagattct atttttgtaa agtcagttcc 3655801 gcctaagatg gtgttaacct tcagtactgg tacagggagc tcttttttaa tcggaatggt 3655861 gctgatgaca aaatcaattg attcgtagga catttgatca agactataat actcagccgt 3655921 tccaagaata tcgagccgct tgccgaaatg ggaacgcagt ttttcgcgca gaagctgggc 3655981 gcttccggct cccgatgcgc atacaatgat acagcgtttc ggcgggcttt ctgttttttt 3656041 tcgttcaatc gcggcgccaa agtggagagc caaatatcca atttcgtttt catgaatctc 3656101 aatacccgtt tgttccttta tcacgattcc ggcaatgatc ccggcttcaa aagcgagtgg 3656161 ataatgttcc ttgatcgctg ccagcatcgg atttcgaaga ttcatgccgt atcggttgcg 3656221 gctgatcgcc ggcttcatat gcagtgccaa gccgattttc agctctttgt catgcaggat 3656281 gccaagcttc agttcacgat caacagcttt gatcatggca agtgtcagct gatcggtttc 3656341 ctcttctatt gaaaatgtgt cctctccgca ttgtgattgt gtcattcgtt ttgtgccaag 3656401 gagatgcatg gtgatgtagg ccgtctcgtc tttcggaaac gtaacggaaa gctttgattc 3656461 cagctctttt acgatggctt ctgcagcctg gtactccttt tgatgcagga tatgatccat 3656521 atctttcggg aaaagagaaa catagttttc cgttctgatc cgtttacagg cgatagcgat 3656581 atggataatg aggttattca gtcccatgtt ggacagaggg atgcggtcgt ttttcatttt 3656641 tttcaagatg gcggaacgga tgatctcaat ttcttctttt ggcaaaatat cagccttttc 3656701 atttaaaaca tctatctccg tttctctttc atcaacaatg tactccgcca tgcagtacct 3656761 catctgcacc tcgtccccgc gcagcttgaa gccgtaattc ggacgtgttt ccatgacgat 3656821 gcggtaaggc agcagacgtt tctttacttc ctttaaatcc gtttggagtg tagattttga 3656881 gataaatagt tcttcagcaa gttcatcgag cttgagataa tggtccgcca gcagcagacg 3656941 tttcataaga taggccattc tctcctccgg caataccggc aggccctttt tttgctgaaa 3657001 ttcatcttgc agcagtgttc tgaatacttg ctcgtcatca atgcggagct tgtagccgga 3657061 gcctcttaca gattgtacaa aggcaccgtg gccgcttagc acaccttgaa gttcctttat 3657121 atcattgcgg actgtccgcg tcgttacgtt taattgcgcg gcaaaaaacg aacttgtcac 3657181 cggggcttca gccgccatca gcaagcgcag aatatcacgt agtcgcccat gaagcatgag 3657241 aaaaacctcc taactagtag atgcagggat tcagtgaata ggcagaaagg atgatgaagg 3657301 gatgcgaaat gtatataaat tctataatgg agagaatggc aagtcaatga acatccggag 3657361 gactagaggg aaaactgacc tataaaaaaa cagccgggat cagccggctg ttctagatgc 3657421 ggacatattc ttttgtttag acgccttgcg gtccttcatg atttttcgaa caatcgggta 3657481 aatgaccggc gcccatttga taacggtttt gatcatcttt ttcaaagctc cgattctccc 3657541 ttcttttttc tcaaccattc ccctgattgc ctcttcctta aacatgctaa cgcgacacgt 3657601 acctgtttcc cgtcacccag aaacgccatg gataatcgcg tgcctccccg ctgttgtcaa 3657661 tgccgatgcg cgggccggtt gaaattgctt ccggtgtgta cccgctttcg atgtaaagcg 3657721 gctgttccgt gatccagcgt ccgtagtcat tcatcgtgac gccaagcgct ttcgtcagct 3657781 ttcctggtcc gtttgtccat tccctcggac tcctgcccgg ccttctctcc tccattaaca 3657841 gctggccttc atgcggctca atcgccctga ttaatactgc ttgcgggaca tcctcttccg 3657901 ccgcaacgac attcagcaat gtatgggtgt gcatcacgta tgtatatacc cgcccagctt 3657961 ctgcaaacat gatctcagtc cgcttcgtcc ggcggttgtt aaagctgtgg gccgctctgt 3658021 ctccagcccc catataggcc tctgtttcca caatatagcc tgacgctgtg ccttcgtctg 3658081 tttcttttac aagaaggcag cccagaagcg atggggcaag ctcaagagcg gttttttgat 3658141 aaaacgtgat gggcagcgga tttttttctc tcgtcacgaa tcgacctctc cttttaccga 3658201 tttttgtaca ttgtaccatt cccgaagcag atcaaaaaaa acggctgttt taaaatcttt 3658261 ccattcaggg aatattgtta ccgttcaaaa aaggagggcc aaccattgaa agatgatcat 3658321 caaaacaagc agcaccaatc aaatgcccaa gggagcgagg aagcgttttc tcataagaca 3658381 tccgggaaaa acgagtcaga ggatacctta acgaataggc aggggcatcc tgttactgac 3658441 aaccagaatg tgagaaccgt cgggaataga gggcctacaa cacttgagaa ctatgatttt 3658501 ctcgaaaaga tcagccactt cgaccgggaa cgcatcccag agcgggttgt tcatgccagg 3658561 ggagcaggtg cacatggata ttttgaagcg tacggaagct tcggagacga accgatttca 3658621 acatacacaa gggccaagct ctttcaggaa aaaggcaaga aaacaccggc atttgtccgt 3658681 ttttcaactg tgaatcatgg aaaacactcg cctgaaacat tgagagaccc gcgcggtttt 3658741 gctgtaaagc tatatacaga agacggaaac tgggatttgg tcggaaacaa cctgaaaatc 3658801 ttttttatcc gcgacccgct gaaatttccg gatcttgtac acgcatttca gcctgatcca 3658861 gtgacaaaca tccaggatgg tgaacgtatc ttcgatttca tttctcaatc tcctgaagcg 3658921 acacacatga tcaccttctt gttttcgcct tggggcattc cggccaacta ccggcaaatg 3658981 cagggttcag gcgtacatgc ctataaatgg gtgaatgagg agggcaaggc cgttctcgtg 3659041 aaataccatt ttgaaccgaa gcagggcatc cgcaacctga cacagaagga agcagaagag 3659101 attcaaggga aaaactttaa ccatgccaca caggatctat atgacgcgat tgaaaatggc 3659161 gattatccag agtgggaagt atatgctcaa atcatgagcg atgatgagca tcctgaactg 3659221 gactttgatc ctcttgatcc aacaaaactg tggtataaag acgatttccc atggaaaccg 3659281 atcggcaaat tggttctgaa caaaaatccg gaaaactacc atgcggaagt ggagcaagct 3659341 tcatttggaa cgggagtgct tgtcgacggg cttgattttt cagacgacaa attgctccag 3659401 gggcgtacgt ttgcctactc tgatacgcag cgctaccgtg taggcgcaaa ttacctgcag 3659461 cttccgatca actcgccgaa aaagcatgtc gccaccaacc aggaaggcgg gcaaatgcaa 3659521 tatcgggtcg atagagcaga aggacaaaac ccgcacgtca actacgagcc atccattatg 3659581 ggcgggctga aggaagcgaa gcaagacgga aaagaccata cgccgcatgt cgaaggtgat 3659641 gtaaagcgtg aagcgattga cagaacaaac aacttcggac aggctggaga aacgtaccgg 3659701 agatttactg aatttgagcg gaacgaattg attacgaatt tggtgaatac gctttctacg 3659761 tgccgaaaag aaattcagga tcaaatgatt gagaatttca caaaagctga tcctgactac 3659821 ggaaaacgcg tagcagaagg gctaaaaaag gtctccgaaa acaacagcaa cgggccgatc 3659881 ggcacaactg aaacggaaca ggctgcaaag caggctgaac aggagagtca tccgtctgat 3659941 ccgtattaac aacagcgaac agggcttttt tagaagccct gtttttttat ttttctattg 3660001 aaacgctttc aataattgtg ttgtacttgg aaggaaaggg gtggagagat acgatggaat 3660061 tacagcagga cttgattcct cagaaaaaaa caatcggcgc tttagatcac gccgtttttt 3660121 tatgcatggt attttgtttc tggttttcag gctatattta cgttcctgta ttcagtctgt 3660181 atttggagga tctgcacttt tcatatggcg caatcggcat cattctcggc agctacgggg 3660241 tcacgcaaat ccttctgcga ttcccgctcg gccttttgtc agacatcctg ttttccttgc 3660301 gcaagcaatt gttaattgcc gggttcggct tttccgtcct cagcagcctg ctttttctga 3660361 tgtttgattc tttcttcttc gtgctggccg cccggctttt cgcgggaatc actgcttcta 3660421 cgtgggtgat ggcgaccatt ttatacgcac attatttcaa caatggcaat gcatcaaaag 3660481 caatgggcat catgcagttt tttaccgtca tgcctcagtt tgccagcatt gtgttctgcg 3660541 ggctcgccgc agcccattta gggaggcagg ttcctttttg gatggcgctg gcagcttctg 3660601 ccgcaggtct ggtgatctgc tgctttattc aggatccgtc tgctcctccc gcaaaccgtg 3660661 gcaccattcg tgtcaatcag tacatcaaag atacattgcg gctgccaaag ctgaagcttt 3660721 tcaccatcct gtctatgacg gcccatgccg tattatttat cacagtgttt ggttttacgc 3660781 cgctttacat gaatcagctc ggaatgggcg acgcggagct gctttgggtg atgagcgcct 3660841 ttttcctccc acacgcagcc gccacattaa gctttgtgtt tctgcgcttt acaagccgta 3660901 tcgcttactc cgtgatgctc attagtttcg ctgtcaccgg ggtctgtttg ctatatgttc 3660961 cttttttagc tgcattgttc acggtttgca tcacacacgc ctgtattggg ctggcgctcg 3661021 gcttcgtttt tcctctgctg ctaagccatg tcgtcgaaat cagttctgcc cgtttaaaaa 3661081 tgtcagtgat ggggttttac caatcatttt atgcgctagg catcttcctc gggccccttc 3661141 ttgccggaaa aatcgcacag cttatcgggc ttgcgggagt tttttatgga gccggttctc 3661201 tggcatttgc cgcctttttt gtgatgctcg cgcaaaaacg taacatgatc aattaatagc 3661261 tttcataccg ccggaagcgc cacacagaaa acacggccag aagcatgatg cacagaatgg 3661321 agaaagtgag tgaccatccg aaaaaatctg cccgctctcc atgaagaagg atatgctccg 3661381 cctgcttgca aatctcagcc ggaagccact tcgcaccatc tggaaatagt gaaacagcaa 3661441 aggaaacggc tgctgtgagc ccgatcccgc aagccgcagc tgctccgaca gaccggaata 3661501 tcgtacttcc ggcaaggccg gcggtcacaa taaatatcac ccaaagagcg taaaggccaa 3661561 ggcttgcggc aaagcggctg aatgatgcgt cctcaaacag cagccggacg taatagtaag 3661621 caagcccgta tccagctgca aacgacataa tgccgatcac gctttggatg agccatttac 3661681 tcacgatata atgggctgcc gtcacaggcc gcgacataat cagcgctgtt accccttgat 3661741 ttctttcatt ggctacactg cccatcacgc taaagatgac cagagccatg ccaagcgtgt 3661801 tgaattgaga aagcgtgctg accatcactt cagacccgga gggcatcgta aaactgattt 3661861 tcatgccgtc aggaaggttc cctccatgtg cgatgatttc cggcatataa taaatggtca 3661921 gcggctgtgt cagcccgacg atcatcatcg caatcggcag ccaaatcagc ttgccgcttt 3661981 tccatccttc cagccactcc ttctgcaata gcgccatcat caccttcatg cgtgcaccac 3662041 ctttagatag acgtcttcta gagactccgt tttctgttca aagcgggtga cggtcaatcc 3662101 ctttcggata cagtcactta ataatgaccg gccagcgtgt atatcaggca gctcgaaaac 3662161 cgcttgggac ggattcttat agacaatagc tgagacgtaa ggcttctctt caagccaacc 3662221 ttccagcttc tctttcactg aaagggtaaa aacgttcgtt tgctgctgtt gtttcagctc 3662281 ctgtaactcg cctttccatg aaatctcacc gtttttcata atcaccactt gatcacacac 3662341 ctgttctgca tcgtgcaaaa catgtgtaga aaacagaacg gccatatgct ttttcagctc 3662401 ccgcatcatg tccagcacct cgaaccgtcc tgtcggatca agcgcagaca ccggttcatc 3662461 caatatcaaa aacttcggtt tatggagcag tgcctgtgcc agaccgagtc tttgtttcat 3662521 gcctcctgaa tagcccccga tccttttgtg cgccgcttcg tgcaaaccga caaattccag 3662581 catctcgccg attttctctt ggcattttct cttcgaaagg ccggacagtc tccccgcaaa 3662641 tgtcaaaaat tcatttgcgg tcatccacga ataaaaagca ggatactgcg ggaggtaccc 3662701 aatcaaacgc cgatccagct ttttctctcc taacagcttt atggttccag aggttggcga 3662761 aagcagtccg gccagcattt gcagagtcgt ggttttgccg gctccattag gtcctaatag 3662821 tgcgacacac tcattttcat tcacgtgaaa actgacattc tttacagctt catggtgcct 3662881 gtacgatttg cataatgatt caatagacag catatcggct tacctttgct ttctgccgac 3662941 ggtgaaaaat aaaatcggcc cgataatatt gatacatacg atgattgcag cccacatcca 3663001 ctttggcccg ttcgtccgct cttcttttat acagctgata agggcaaaca ccgccaaagc 3663061 cagctgtaat acaatcagcg gcaaaatcat ttcccaagaa atattcattg cttgatcccc 3663121 cttttcttcc gatccggcct aatgacaaaa aagtaataac aaatcagagg catcggtgct 3663181 tgaatcaatc cgacaatccc ccaaacccat gccatgtgat tacgtttttt cgcatcaata 3663241 aataaaaaga ttccctgcgc caatacgatg agacaagccg caaccgttat gataatttct 3663301 gtttgtgtca tccgcgtttc acctcgcatt cgccgagatg cctttttttc tcagccgcaa 3663361 tcaaaatcgg cagcaccgca agcacacaaa cctgaagcac aataaacaca gcaggagctt 3663421 gagtgaaagc taagattgca gcactcacaa ccatcagcgc gcagaataca aataaaatga 3663481 tctcttgaag aagttttttt ctgtattcag ctttcatttg tgacagctgg tgaagcagtt 3663541 ctttttgatt cggtatagag ggattggctg tttgatcaat ttttttccat tctgacttta 3663601 aatgatcaga aagcttttct ttattcatca tcccactcct ttctgatttg ctggagccct 3663661 ttatgaactc tggactttac agtgccttct ttgatttgaa gcatcacccc gatttcagcg 3663721 taggtatagc cgtagtaatg ccttaataaa accggtgtgc gcagtttagg gtccagcttt 3663781 gaaaacagat cgagcgtttc gctccactct gcccctttcg ccgacacgtc ccacttgatc 3663841 ttgcggattg tttcctccgt aactgtctga ttccgtttcc attctctctt tctctttttc 3663901 tggtgatcga gatagagccg cgatgcaatg gagatcagcc atgtggagaa ttttgaacgg 3663961 ccctgaaagc ttcttaaatg gatgtaccct ttcagaaagg tttcctgaac aagttcctcg 3664021 ctgagatcgg ggtgaaggga aagctttaac aagtatttat ataagaaaga atagtgatag 3664081 tggaaaaggg ctgtaaacgc ctcgtcgttt ccctctttcg cctgctggat cagccgctgt 3664141 tcttcttgtg tatccaatga ccgtgatccc cccttttttg tttttctgcc ttatgagacg 3664201 acaccggatt caaaagcgtt catctttttt acaattcttt tcagccattg acagatcagg 3664261 cttcccggcc gtttggctgc atatccttat ttgtaaaccc ccttatagtc tgttaagcta 3664321 tgactttatg tcgatttcaa aaaaacatcc aatatggagg acgatgcatt gaaagtagaa 3664381 aggcgaacga ttgaatatat tccgaatgaa gaaagacatg gtaaagcgaa agatttattt 3664441 cccgtatggt tcggggctaa tatgcatatc accacgttag tgaccggcac gattcccgtt 3664501 gcaatgggac ttaatctgtt ttggagtgtt gccgctatta tttgcggaac cttaatcggt 3664561 gccatattta tggcttctca ttccgcgcaa ggccctcagc taggcatccc gcaaatgatt 3664621 caaagccgtg cccaattcgg cgtaatcgga gcgattcttc ccctcttctt agtcatgttt 3664681 atctaccttg gtttcttcgc aagcagcacg attctggcgg ccggaacctt aagcagcttt 3664741 gttcccatcc cgggatcatg gagcattata ggcttaagtg ccgtatgttt tttactcacc 3664801 attttcggcc atgatttgat tcacaaaatg caaaaaatcc tttcttggac ctcttttgct 3664861 gtattttttg ctgcaacgat tctcattttt caattgccga ttccggcagg cagctggata 3664921 cccggagcga ttgatctgcc aattttccta gtggcagtca gcgcagttgc gacgtggcag 3664981 cttgcctacg cgccgtatgt tgccgattat tcaagatatc tgccagttaa aacaccggct 3665041 tcaaaaacat tttggtacag ctatgcaggt acatctgtca gctccatctg gatgatgctg 3665101 ctcggcgcat tgctgacaac ctcacttcct gactttacgg caaactcagg cagccagatt 3665161 gtccaattgt tcggtccctt ctcgtttatt atgctgatca ttgtgctatt tgggcaaatg 3665221 gcaatcaatg tttttaacct gtatggggct ttcatgtcca cgacaacaac gctggagccg 3665281 tttctgaaat taaaagtcac gcccaaagtc agaatcatca tgatcctggg tgtcacgctt 3665341 gtcggcacag tcttaagcct actgggacag agcaatttta tggaactgtt tttgaatttt 3665401 atctttttca tcagttattt cttaattccg tggacggcaa tcaatttagt cgattactac 3665461 ttcgtccgcc acggaaagta tcaagtcaaa gccatgttcg acgtaaacgg gccttatgga 3665521 aaggtcaatt ggatcaccac aattgcgttc gttctgtcta tcttgctgga aattccgttt 3665581 atcaacacaa gcttttacat cggaccgctt gccaaaatgt ttggcggcgg agacatcgca 3665641 tggattatcg gcttggccgt gccttctgtg ctttactatg tattaatgaa accgcgtctg 3665701 aaaaaacggg cggggtatca agaaaagctg tcttctctct gaagacagct tttttatcat 3665761 tcaaatcgtt tccacacgcg gggcaggatg tcagatagct catgagcgag caacgtatga 3665821 gcggagtgct cgtccgtcca gagctcggcg cacgcaccat gcaaatagac cgcgtttaat 3665881 acggcgtgct ttggatcttc atggcagcag agcatcccca atatcatgcc cgtcagcgtg 3665941 tcaccggttc cgcccttggc gagcgccccg tttccggttg gattgagcca gcagtctcca 3666001 tcaggaaacg cgatgacggt ttggtttcct tttaacacaa tgacagtctg cagctgagcc 3666061 gcccattcct ttgcatattc cgctcttttt ttctgcaatt cgttcacggg cacccctgtc 3666121 attcggaaaa actcgcccgg gtgcggcgtg aggatgacgg ggccctcccg tttcggatat 3666181 gtgcgcttcg ccagcgctcc ggcatccaaa ataacaggac aatcagccgt aagcacatga 3666241 tcgactgcct gctgtacgct ttccgtttgc ggaaggcccg gtccgatggc aatggcccgg 3666301 tacgtctctt caagctgagc atccgccgcc tttttccagc cgtcacgcca ataggtcgcc 3666361 tcgggcaaaa caggaacaat tagcgggatt acgttttctg atgtaccgat gacaagcttg 3666421 ccgagaccgc tccgcatggc cccaagccct gcaagcagcg ctgctcccgg catgtcgtca 3666481 cttccagcca gcagcaaagc cgtaccgtac gtgcctttat ggctctccgc atctctttca 3666541 ggaagcgtgg cccttacatg ctcttccgtc caaaatggaa cattcatctc tatccctcct 3666601 ctgctttctt ttcctatttt tcctgtccct tttctttttc aaacaaaaaa gacagccttt 3666661 tagggctgtc ttttatttta caggaacatc aaggtgatac aggcggcgat atcgttcgtt 3666721 tgccgccagc agctcctcat gggttccttc catttctgtt ttgccgtttt cgagaaatac 3666781 gattttatcg gctgcttcca ctcccgcgag atggtgtgta atccataaaa tcgtttttcc 3666841 tttcagcacc tcaaacaccg tttccatcaa ttcacgttcg gtaataggat cgaggccgac 3666901 tgttggctca tcgaggatga tgatcggtgt atcctgcagc aaaatcctcg caagtgcgat 3666961 ccgctggcgc tctccaccgg aaaaacggat gccggtttct tgtacagagg tatgatatcc 3667021 gtcaggcaat gactcaatgt agtcatgcag cttgacctgc tttgcggcgc ggcgcacatc 3667081 ctcgtcgctt gcttctccgt ttccgagcct gatgttgttc aaaatgcttg tatcaaacag 3667141 gtgcggtttt tgatttaaca cggccaccgc atccgcaatc tgatccttta acagcgctgt 3667201 ctccactccg tttaacgtca cagaaccgga gtccggtttc aaggcgcctt cgattaatgc 3667261 aagcgatgtt gatttcccag agccgcttcg gccgagcagc gccatttttt ctccttggcg 3667321 cagcgtaaag gaaaagttgt gcagcacttg gctgctgttg tcataagaaa acgtcacatc 3667381 acgaaaggcc aaggtgacat cttgaagatc gagaatttga tcccctgatt cagtttgtga 3667441 cgcctccggc tgaggagcca cattgttcat gcgtctgata gaatcctgat agcccggcac 3667501 ttcgcctaag gcatccgaaa gcggcaaaaa ggcttccgtc aacggaaaca ccactagcac 3667561 aaaagcggca atcatcgttt tagcgagctc gccgtccgct tgctgtcccg ctgtccaaaa 3667621 cagcatcagc aaaataaggc cagcgacaag gcattgcgca gcaaagtccc gccatcttgt 3667681 aaagcgttgt tttttccgtt caagctcaaa ccaatcacgt tcctcttttt cataagcatc 3667741 aataaaagca tgccggcgtc cgctgaacat ccagtcgctg acacccatca cagcatctgt 3667801 cagacggctg tacagcacat tccgtccgct tttcagcttc gcattcttcg ctctcgtcac 3667861 gagcaaagac acaaccggaa acaatacaac aagaacaaac aaatacagcg caagcaatat 3667921 ggcaaacggc caagagaaga agccgagcgc tatcactgac acagcataca ggagcaaggc 3667981 tgagatcgca ggaaaaatcg tttttaagaa agcatcctgc aaatgctcaa tatcctcaga 3668041 caaaatgccg agcatatccc ccgtgcgaaa acgggaacgc agcatcaaag cacccggctc 3668101 aagcatattg taaaggcgga cgcgcatgtc agatacgatt ttcaaaatga tgtgatggcc 3668161 gacgagccgt tccacatatc gcgacacaga gcgcgcaatc ccaaaggtgc gcacagcgac 3668221 aatcggcaca taaatgagca gaatgttttc cggccttgtc gccgctttag aaatcaaaaa 3668281 acctgaggtg aacatgagaa aagcagcaga aaaaatcgtc accgcaccca aaaagataac 3668341 cagaacgaac aggcgggcat tttgcttgat atacggcaaa atccattctt ctttcttcat 3668401 gctctttccc ccagttgtgc cttcacgagt ttggtataca caccgttttt ctccagcagt 3668461 tcattgtgag tcccaatttc cgcaaccctg cccccgtcaa gcacgataat ttcgtccata 3668521 tcgagcatcc agtgaaggcg gtgagtcgcg agaaagacga gcttatcctc aaataaatcc 3668581 agcatcgttt cttttatttc atattctgtt tcgatatcaa gatgggcggt cggctcatcc 3668641 agcagcagga tcggacggtt tcccaaaaag gcgcgggcca gcgcgacacg ctgtgcctgg 3668701 ccgccgctga gcgcccggcc gccttccccg atccgcccct ctaatccgtc aggaaggttg 3668761 ttcaccagct ccgtcagtcc cgctgaggca gcagcacgtg ttgtatcctc tgccgaagcg 3668821 cttggatggt agaagcgaat gttgttgcca agcgtatcat caaaaatgta cggatgctgg 3668881 ggaatgtaaa gaaggttctt ctgccagctg ccgtcctgca aatgggaccg gcttgtacca 3668941 ttaacctcaa tcatcccgcc atccggctct aaaaatccgc cgagaatatc aattaatgtt 3669001 gattttccgg cgccgcttgc accgataatg ccgatttttt tcttgccttt gaatgagaga 3669061 tgaatatcag acaccgaacg gccgactgac acgcctgaca gcttcagctc atcctgatcg 3669121 gaccaagctt cgagctgaag cggcgtctct tctttaaaac caggctgcga caaaatctct 3669181 tgaatggttt ttcctgcttc ctggccgttc agcgttgcat gataatcatt ccccacttcc 3669241 cgcaccggca aaaaatactc aggcgccaga ataagcgccg ttaaagcagg gccaagcaaa 3669301 atatcgccgt caatgaggcg caggcccaga aatactgcga ctgtcgccac cgacagcatc 3669361 gtgaaaaaat cgagggcgaa tgatgacaaa aacgccaccc ggagtgtgct catcgttgcc 3669421 ttgcgatacc gctcactcac atagaaaata tttttgctgt gtgacttgct caaacctagg 3669481 aaacgcaatg tctccagccc gcgaagagaa tcaacaaaat gattggaaag tctctgatag 3669541 gatttccact gacgatccgc ttttctctgc gcgacaaggc cgaggagaat cataaagatg 3669601 atcagaatcg gcatagcagc gactaaaatg atggctgatg tccgatcctg aaaaaacaca 3669661 taaatgacaa ctgccgcagg cacaatcgcc atgctgacca ttttcggcag aaacagctcc 3669721 aggtagcggc ggaactggct gatgccttcc atcgccagcg tcaccatttg ccccgtcccc 3669781 tctttctttg caaagcgggg gcctaatcgg aacagctgat caagaaaact tttcctcaaa 3669841 tctgctcctg tccgggcggc gtattgatag acgattttct gtcgcgccac cgtcatcccg 3669901 tgccgggcga taaaagcgat gaggaaaaag ccgatcaccg gtaaaaggga ggtaatgccc 3669961 ttcccgttga acagtccggt tacggcctca ctcagccact ctgcctgcat aataatggcg 3670021 gctgtctgaa tcaacgttaa acaagtaatc aaggtgagaa tccgcttcat tcctttatat 3670081 cgaaacaggt cttttcccat taataagtca taggctcctt atggctgacg cgcttccgga 3670141 agacataata gctccagatc tggctgccga tgacgaacgg caatagcgtt aatgctgcaa 3670201 ttgacatgac tttaagcgaa taatctccag aagaagcgtt agctactgtt aaatcgtatg 3670261 cgctatgaag cgagctgacc attacacgag ggaataggga aataaagatc attcccacgg 3670321 tcagcgccag accagcgcct gtcatcccaa atgtccagcc gtcttttttc ttacgaataa 3670381 atacagccgc gagcataaag cagatgacaa tcaaaacagc gagcggaatg gtaatctcgc 3670441 cgcggcgtgt aaacatgtct gtctgatacg cagaaagggc cgcgaaggca agaaccgcta 3670501 caaaaacaac acccattatc ttttgcgcca ttttccgggc gcggttttgc aaatcaccaa 3670561 tcgtacgcag cgtgataaac attaatccat gctggaagca aagaagcgtt accgtcacac 3670621 cgccaagtat agaatataca ttgatataat cagatacatg tgcgtgaatg ttcatgtcgg 3670681 catcaatcgg catcccgcgg aataatgtcg tgaacagcac accaagcaca aacggaggaa 3670741 ttagactgcc gaaaaaaacg acccagtccc aaacctttac ccattttaaa tgatccacct 3670801 tgccgcggaa ctcaaacgcg accccgcggc ccattaacgc aagcagcact atgacaaacg 3670861 gaatgtaata accgctcagc atcgttgcat accagtttgg gaatgccgcg aaaatggcgc 3670921 ctgcgccagt caaaagccac acttcattcg cgtcccagaa cggcccgatc gtgttgatca 3670981 gcactctgcg ttctaattca ttatggccaa gaaaacgggt cgccatgccg accccgaaat 3671041 caaagccttc caaaaagaag aatcctacaa acaatacagc aacgagtata aaccaaagat 3671101 catgaagaga tgccatggta tacctcctga ctaaatggat ctgttgatac aggcacatca 3671161 tgatgattat catgctccgc acctttttta atctcacgga taaacaagaa gacaagcagt 3671221 gcaccaagaa tcatgtacat cacaccgaat gcgatgattg agaataacaa ggaacccgct 3671281 gttacgttag gcgacacaga ttgagcggtt gtcattaacc ccataaccgt ccaaggctga 3671341 cgtccgattt ctgtcataat ccagcccgcg gagtttgcaa gaaacgggaa ggaaatcaac 3671401 gcgatcatga tgcgcaaata ccatttgctg ttttcaagct ttttacggcg gtttaaccaa 3671461 aggccgccta acgcagcaag aatcatgaca acacctgctc ctaccatgat gcggaagctc 3671521 cagaatgtcg ttttcactgg cggaatgtag tcgccttttc cgtatatttt ttcgtactca 3671581 gcctgaaggg ttttcatccc tttgacactt ccgctgaatt tctgataagc caagtagctc 3671641 aaggcataag gaactttgat ttcatttgag cttttttcat tttttgtatc gatcgtcgca 3671701 aaagcggtcc aagcagcagg gtcaccgctg tcttcccata ggccttcact ggcagccatt 3671761 ttcatcggct gtgattccat caagtgctca gcctgcatgt gtccgctaag gccgacgcca 3671821 agaccggcac aaagaccgac gatcattgcg agtttaaaag attgcttaaa gaacggcact 3671881 tcttttttct tcagcagttt aaaagcactc actccggcaa taaagaaagc tccagtggca 3671941 agcgcaccga aaataacgtg cgggaattca acccaaagct gagggtttgt aatcaacgcg 3672001 ccaaaatcat tcatttccgc gcggccgttt ttgatcgtaa agccgaccgg ctcctgcata 3672061 aaggagtttg ctgttaaaat ccagaaagat gacatgatcg ttccgaatga tacgagccat 3672121 atgcagagcg cgtgaatttt cttcggcagg cggtcccagc caaaaatcca taatccgata 3672181 aaaatagatt ccatgaaaaa cgccaataat gcttcaatcg caagcggagc gccaaataca 3672241 tctccgacaa aacgggagta atctgaccag ttcagtccaa actggaattc ttgcaaaatc 3672301 cccgttacaa caccgactgc gaaatttatt aagaataagt gtccccaaaa ctttgccatt 3672361 ttgagataca gctcattttt ctttacaaga taaagagtct ccatcaacgc aaccataaac 3672421 acaagcccga tagacatcgg cacaaacaag aagtgaaaca acgttgttga tgcaaattgt 3672481 atgcgggcta ataccaattc actcatgctt tctcctccat ttccggttaa aactgttaat 3672541 ttgctcacta cttcacaaat agaaccgaga ctttgatcag taattcacaa aatagacgaa 3672601 aaaaatattg ctcaatattt cacaaatgtg tcaaaaagtc atccaatatg atgcaagatt 3672661 gccagactga ccaaatgaca caatctctga ctggttcata ttaagtactt tacaacgatt 3672721 catttcaaaa ataaagccta aaatacctaa aaagtcccgc actatgtgac ggatttttgt 3672781 ctattttgtt gcttatttat gtcggctgct aggataaatg accctttatt atcgtacatc 3672841 aacacatcgt tccttgcgaa caaaatgctt gcccccgccc cagcactcga gtctcagcat 3672901 tccgtcttaa accgatttta gtcagaatgc ctcttttcat ttgaaccggt aagaggagaa 3672961 aagttgaata gtaaattttt aatatattaa taatttcaat tttttagtat acttaacata 3673021 gtgaacaatt tcactgcatc aagaataggg gaggtttttc aatgggagag cttcaaacac 3673081 acatgcaatt gcaaacggat acaattcacg aaggggttcg aaaagagaat tggtttgcga 3673141 aagccatgaa tataaaagta ggcatcatac cgcttcctgt gtatgccttg ctgtttatat 3673201 taatcactgt ttttgttatg catcacgatg taaaaagtga cattttgaca tccattgccg 3673261 tcatggcgtt tttcgggttt acctttgccc aaatcggcaa atcgataccg attgttcgtt 3673321 ctatcggcgg cccggccatc ctagctactt ttattccgtc cgctgtcgtg tactatcacc 3673381 tgctgcctaa tgatatcgtc aaatccacca cagaatttac agaaaactca aactttctat 3673441 atttgtttat cgccggtatt gtcgtcggaa gcattctcgg catgaaaaga gaaacactcg 3673501 taaaagcatt catgaaaatc tttattccgc ttattgtcgg ttctgtcaca gccgctattg 3673561 tcggactggc tgtcgggaca ttgctcggac tcggatttca gcataccctg ctgtacattg 3673621 tcattccgat catggctgga ggagtcggag aaggcgctat cccgctgtcc atcggatatt 3673681 ctgacatcat gcccatttct caaggggaag cgtttgcact tgttctgcca tcgattatgc 3673741 tgggcagctt gtgcgcgatt attctagcgg gattgctgaa ccgaatcgga aagaaaaaac 3673801 cggaatggac aggcaacggc aaagtggacc gctccgaaga agagtcccct gcgctggagg 3673861 aatctcaaag cggacagcaa atgttcaacc tttctttatt tgcgtcaggc ggtatccttg 3673921 ctgtttcttt atacttagtc ggcatgctcg ctcacgattt tttcggtttt ccggcacccg 3673981 ttgccatgct gttactggct gttctaatca agctgttcag attggtgcct gcctcaattg 3674041 aaaatggcgc gtttggagtg tcccgcttct tttcaacagc tgtgacctac ccgcttctct 3674101 ttgcgattgg ggtatccatg acgccgtggg acaagcttgt cgccgctttt aacctcagca 3674161 atattatcac gattctgtct gtcgttgtga ccatgatggc cgttggcttc ttcactggaa 3674221 aatggctgaa catgtatccg attgaaaccg ccattattaa tgcatgccat tctgggcaag 3674281 gcggcacggg tgacgttgcc attttaagcg ccgctgaaag gcttgagcta atgcctttcg 3674341 cccaggtgtc tacccgcatc gggggcgcga ttacagtatc cttaacctta ttgctgctgc 3674401 accagtttta ttgatccccg caagcaagtt cttcgtcaaa cgaaagagct tgcttttttg 3674461 catgtccatg tttttgcaag ttcccatccc atgctatagt aatagttgga aatactagat 3674521 agaaaggaat ctggcatgcc tatgggaact catctatttc tctttatgct tctcgggctg 3674581 ggattttatt tgatatcagc cctagctgca aaactcattc cggccataga cttctggatt 3674641 gatattgttc tatgggtcgg cgctgcggct tacatcttct ctcatctctc attcatggac 3674701 ggcattgtct cactcgcgac aatgttctac tgctattgga ccgcaatgga tctcattgtt 3674761 tcagagcgtg tggaaaaacc ttcgggagac tggcaggaaa tcgagcttgc caaaaacaaa 3674821 acacgcctcc tgtcagacat tacgctgacc gccattgtgt ttgcaggggc tgtcattttt 3674881 ttcatctatg gacctgacac aagccctctc aaatatgtga tccttctcgg aatgatctcc 3674941 ggcggagggg cacttgtgaa gcgaatactg aatgttttta gcgtaaaggt tttttattca 3675001 gcagccttag aaaaattgca tatcagctca cactatgaaa cccgtacata cccgctttcc 3675061 gatttgaaga acattcagct tgaatcaaca gcagatctct taaagctcca tccgcttctg 3675121 acgatgtatt catcccgttt agatttgaca acaagctttc agcaagtcat taaactgtct 3675181 cttcccggcg aaacactgtt tctgacggtg aaggaaccgc aaaaatggaa aacaattctt 3675241 caggaataca cagatgcaga aaacaatgtg gacaatgtga tttctgtttt gccgttttat 3675301 catcgaaaaa atgtgaagcg gctgctcggt aagctttatt ttgccgccag cgtaaaaggg 3675361 gtatccgctt acgccttatt ggtgctcgcg ttatacgcat tacacgcctc tccatgggtc 3675421 atggctgttg ccgtaatcct atattgggta ttcaacatgt atatgtcaga ccgtgtgttg 3675481 cgggcggcga tggacgccaa gtcttgtcat catccgcatg tacaggccgc ggccgataag 3675541 attttcagat cggccggcat ttcccatgtc cgcatatacg aaacggagag tgatgattac 3675601 aacggaatgg cagtaggcat gaatgtcggg aggtcaatgg tcatcctgac aagcgccaca 3675661 ctaacacttc cacagcgtgt cattgaaggc attctggccc atgaggcgat tcatatcaaa 3675721 aaacgtgacg ttctgtcatc acagcttttg cgttttctat atcttggagc tgtcgtgggg 3675781 attttcctct tgtttgagca gcatatcacc catcccgagg cccacaaaat tgcgctttgg 3675841 gctttcatta tggcaatcat tatcctattc cagctctatc aatccttttg ttcacaatgg 3675901 atggaggtgc gtgctgacaa ccttggcgca tcattgctgg acggcggtta caaacaaatg 3675961 gctgaagcct tgagaatctt ggcggttcgg caagatgagg atatacagaa acaaagtgcc 3676021 tatagctctg aagcaggtga agacgagctt caaattgatt ctctcacccg tgataaaagc 3676081 tggtttttca gattgattga ttttcagttc gctcctcatc ctcctatgta ttggcgtgtc 3676141 ggcactttat tgtcaaacaa aggacatggg gtgctaaagc gctggctcag agaccgactg 3676201 aaagaatcga tcactttgaa atgaaaccgg tcagcgtttc atccgtataa cagatatggt 3676261 gaaaaaaggg agtgacgcga agtgattgtg atcatcttat tgtttatatc tattattgtt 3676321 tttctttcag tcattcagcc gcagccctcg aaaaacaaaa gccgccagca ggcggacagc 3676381 gggtatttcg gttattcaga tcatagctca caccatgatg gatgcagcag tgacggaggt 3676441 ttcagcgatt ccggctgtgg cggcggaggg ggcggcgatt aaacgccgcc tttttttatt 3676501 tcattgattc gatgtacgca ccaaaagccg agcctgacat gcctggggac acgcgcacac 3676561 gatggagggc atacattccc tggtctctcg aagccgcgcc cggttctgtc gtcacgccca 3676621 tttgatagcc tgttttttca gcggccttca gcgtctcctc attgtagcgc cctaccggat 3676681 agctgatgat ggtggtttgc tgatgaaaca tgttgtcgaa cagctttttc gaatcagcca 3676741 tctcactttg ctgctgttga ggcgttaatc cgttcagctc aaggtggtca atcgtatggc 3676801 tttcaatcga tatgccgtgc tgtgccattt ccttcatttg ttcctctgtc agatggtgct 3676861 tatgtccgat cgatttgccg atcataaaaa tcgttgcctt catcccgtac tttttcagca 3676921 ccggatacgc atcttgataa ttgtcggtgt acccgtcatc aaatgtgatc agcacgcact 3676981 tctcactcgg ttttttatcc tgcgtcagca tgagagatgc ctctttcggc gttaatgtct 3677041 gatagccgtt atcatgaagc cacttcatat gcgcctcgaa ttctttcttt ggcacacgga 3677101 ggctgtttcc tgaagaaatg ctgtggtaca tcaaaatcgg cagctttgcc ggtttctctg 3677161 ttttgatcca tgcggatgta tcgtcttctt ttttctgaac ttgtactgcc tttttttccg 3677221 gtttcttttg ttccgctttt ggcatcggct gctctgcatt cgcctcttga tcagcacaag 3677281 ccgcaagagc caaacagctg cccaaaagaa agatgcttaa aaacaatcgt ttcatcgttc 3677341 tcctgctttc tgtctatttc ttcctccttt ttcatcggtt tgattctgag attttcaata 3677401 gcaaaaaacc ggacatgtct ccatgtccgg tttttttgat cttatcggat tctcacttct 3677461 gtctcactgt caaagaaatg gcctttattc atatcaaatg caaccgtcag ctcatcgccc 3677521 gattgaatat cgaggcgggc gtcgatccgc gcaataaagt cttggttgtc tatctgcgaa 3677581 taaatcataa tttcagaacc gagcagctct gcaacattaa ttttcgcctt aatcgaagag 3677641 ttcttatatg attccacgac aatcaattca tcatgtatat cctcaggacg gatgccgaag 3677701 atgacctctt tgccgatgta gcctttttca cgcagcactt tcatttttcc ttccgggacg 3677761 gttaatgccg cagaaccgat tttgattaag ccatccgtga gctttccttt gaaaaaattc 3677821 atcgccggtg atccgataaa cccgccgaca aagacgtttt cagggaattc atatacatcc 3677881 ttcggcgtcc cgatctgctg aattttccca tctttcatga ctacaatccg tgtcgccatt 3677941 gtcagcgctt ctgtctggtc atgcgtcaca taaatcgttg tagtctgcaa tctctggtgg 3678001 agcttaatga tttccgcccg catttgcacc ctcagcttcg cgtccaggtt tgacaaaggc 3678061 tcatccatca ggaacacctt tgcatcccgc acgattgccc ggcccagcgc aacccgctgt 3678121 ctctgtccgc ctgacagcgc tttcggttta cggtgcaaat attcctcaag cccgagaatt 3678181 ttagcggctt cttcgactct ttttttgatt tcaggcttcg gcattttccg aagcttgagc 3678241 ccgaacgcga tattatcgta gaccgtcata tgcggataaa gcgcgtagtt ctgaaatacc 3678301 atcgcgatat ccctgtcctt tggcgctaca tcattgaccc gttttccttc aatataaaaa 3678361 tcacctttcg aaatttcttc aagtcctgcg accattcgca gcgtcgttga tttcccgcag 3678421 ccggacgggc cgacgaatac gataaattcc ttatcggcaa tatgaaggtt aaagtcatca 3678481 accgccggtt ccttctgatc ataaaattta taaatgtgct ccatccgcaa ttcagccatc 3678541 taacatcccc ctttgttatt gtaaacgctt tcttatattg agtgtaacag caattccctc 3678601 tcgctaaaat gggcagcgtt cataaaatca cccagccatt tttcgtgcat atttccaatt 3678661 tattctgaac tttcattttg caggcagata aaataggcaa gaagcgcgcc tttgtacgat 3678721 ttgatatcta tccctgaccg ctcaataaat ttatcaatcc gatattgcag gctgttgcga 3678781 tgcagatgca gctttttcgc tgttaatgtg acgtttgagt tgttttcaat aaacagctta 3678841 atggtcttcc ttagctcaga ttcacttcca aataaaagct cagcttcttc agagagcagt 3678901 gtttccagtt tttctttttc tgtttctaat aatagaaaag gaaagatcat ctcaaaggtc 3678961 acactctgca cctgaggcag ccgtttttca gcaaacagga aatacgcctg ttcacgagcg 3679021 taatgttttc gcagacactc atccggctcg taaaatcttc cggcgtaaaa acggacactg 3679081 aagtagaaat cactttcaag aaccttagcg agcgattcca gttcgtcctt ctccgccgcc 3679141 gcttcacttt cctgctcgac aatcacacct ctgtcctcat ggatccacac aatcacaaaa 3679201 gacaccggcc aaaaatggcg aaccgcttcc gtaaaggacg tcctttctat tttgccgaat 3679261 aaatgaaagt gaacaaatct cgtccgtttc tttatatacg ccggcaattc ccctctggaa 3679321 aaaaggaacg aaaaccactt gttttcctca ggtgatttca tagacagttg attgccctca 3679381 tccgcaggcg tcaaaaatga ctgcagcacc aatacttctt tttcactgat ctctgttttc 3679441 ggaatggaga tatatctctg attgctctca tcaaaaaaac atagacagcc ttcccttatg 3679501 caaagctcct cagacacaat cgaaccggga taaatagcca gcagcgattt catagagtct 3679561 cctctcttat gtaaggatct gtatattcag tataaggcga aacacacatg ttctccacta 3679621 aaaaagagta tatccggtat agatagacga gaaactgaaa gggaaacctc attcgtttac 3679681 atattggctt cagcggaaat agaagaagac atgcaggacc aaaggagggt catcttatga 3679741 gtttcgaaac gttaaacaaa agttttatca acggaaaatg gactggggga gaaagcggac 3679801 gtacggagga cattttgaat ccgtatgacc agtctgtgat cacaacagca tctttggcaa 3679861 cgggcaaaca gcttgaggat gcgtttgaca ttgcacagaa agcccaaaaa gagtgggcca 3679921 agagcacgac ggaagaccga aaagccgtgc tgcaaaaagc gcgcggctat ttacacgaaa 3679981 accgtgatga catcattatg atgatcgccc gcgaaactgg cggaacgatc attaaatcaa 3680041 caatcgagct ggaacaaacg attgcgattt tagatgaagc catgacgtat actggtgaat 3680101 taggcggcgt caaagaggtg ccatccgaca ttgaagggaa aaccaataag atttaccgcc 3680161 ttccgctagg tgtcatttca tcgatttctc catttaattt cccaatgaat ctatccatga 3680221 gatccattgc gcccgcaatt gcgctgggta acagcgttgt tcacaagcct gatatccaaa 3680281 ctgctatttc cggcgggacc atcattgcga aagcgtttga acacgccggt cttcctgccg 3680341 gtgtccttaa cgtcatgctg acggatgtaa aggaaatcgg ggacggcatg ctcaccaatc 3680401 caatcccgag attaatcagc tttacagggt caacagcagt cgggcgccac atcggtgaaa 3680461 tcgccggtcg cgccttcaaa cgaatggcac ttgagctcgg cggcaacaat ccatttgccg 3680521 ttctttcaga tgcggatgtc gatcgtgctg tggatgccgc gattttcgga aaatttattc 3680581 accagggaca aatctgtatg attatcaaca ggatcatcgt tcatcaagat gtatacgatg 3680641 agtttgtaga aaaattcacc gcccgtgtca aacagcttcc gtacggcgat caaaccgatc 3680701 cgaaaaccgt tgtcggcccg ctgatcaacg agcgccaaat cgagaaagcg ctggagatca 3680761 ttgagcaggc aaagacagac ggcattgagc ttgcggttga aggaaaacgc gtcggaaacg 3680821 tgctgacgcc gtacgtcttt gtcggtgcgg acaacaacag caaaattgcc caaacggagc 3680881 tgtttgcccc aatcgcaacc attattaaag ctggcagcga ccaggaagcg attgacatgg 3680941 caaatgatac tgaatacggc ctcagctctg cggttttcac ttctgattta gaaaaaggcg 3681001 aaaagttcgc cctgcaaatt gacagcggca tgacccatgt caacgaccag tccgtcaatg 3681061 attcgccgaa tattgccttt ggcggaaaca aagcaagcgg tgtcggccgt ttcggcaatc 3681121 cgtgggtcgt cgaggaattt accgtgacga aatggatttc gatacagaag caataccgca 3681181 aatatccgtt ctaaatgaaa aaatccctct gtttcaagta cagagggatt tttctttatt 3681241 tagatatatc cacaaaccct tcgccaaaca catcgcgtac gtcatgtacg atcacaaacg 3681301 cttttttgtc gcagcttcta atgatttttt tcagcataga cagctcctgt ttgttaatga 3681361 cgatatacaa aatctctttt gactggcccg tataatttcc cttccctgat aaaatcgtca 3681421 cgccccgatc catcaaggta tttacctgct ctgcaatctc actcttattt tctgaaatga 3681481 ccgtaatggc ttttttcgta ttcaaacctt caataatgaa gtccatcact ttggtaccga 3681541 tatacagcat cacgatcgta aacatcattt tttctgcacc aataataaaa taagagctaa 3681601 atactacgat taaatcaaaa aacaagagtg catagctgat attccagtct aaatatttat 3681661 tagcaattct ggccagaatc gcggaaccgg ccgtcgtccc gccgacccgg ataatcatgc 3681721 cgatcccgac tccggcaaat acacctgcga aaatcgtatt aatgatcaat tcatcagacg 3681781 gaatgctcca cccatgtgtc agatgaagaa aaagcgaatt tgccgcaacc gcaatgatcg 3681841 tataaaccgt tgtttttcca tcaagaaact tgtagccgat taaaagcaaa aacgcattta 3681901 agataaagtt cgtgacacca ggagaccatt gaaacagata atacaaaatc agcgtaatcc 3681961 cagtgactcc gccttcccca agatcattgg gaatcgcaaa taaattaacc gcaagcgcga 3682021 agaaaaaagc gccaatcaca agcataagta catccagcat tctctttttc atcacgaaaa 3682081 cactcctttt cattgttctg ttctagcaaa taaaaaaacc caggagaacg ctctcgaaaa 3682141 agagcagaaa ctcctgggct tttatcccac cgtgtcataa cagccaagct gctatgtgtt 3682201 ttctctcggt cacagtccaa tttgcattgc ggaaccctag aaaaccactg tttttatcat 3682261 atccttttca ctttccaata ttagcattat aagggacggt tcgaattggt tcaaggggta 3682321 tttgcggagt tttcatcaga taagctggaa aaaaatacga tttatctatt aaaaaagaac 3682381 agatataacc gataagaaaa aaagcatata ttttacaagc gaatgtaact ataaatgata 3682441 ataattataa gaaattcata attttatatt gactaagaga aataatatag gcattatagt 3682501 acatatgttt cgtacatttt attacatagg aggaaatata atggcaggaa aactagtacc 3682561 ctgtaaagct tgcggtcaag aaattgcaaa gggtgtaaaa aaatgtccta actgcggtaa 3682621 ggatcaacgt aactttttta tgcgacataa aatcattacg tttattctcg cagttgttgt 3682681 catcattatt atcggtaata tgattggcgg cggaggcggc tcagaagcca cttccaaaac 3682741 atcaagcagc agcaaagcag aaactgaaaa aacatacaat atcggtgata ccgtaaaaac 3682801 tgaaaaaact gaagtgacgg ttacgaaggt agaggacaga gatactgtcg gtactcaata 3682861 tgttgaaaag aaagcatctg agggaggtac aattgtagct gttcaatata caattaaaaa 3682921 cgtatctaaa aagccgatta gctctttttc aattccaact gttaaattag ttgatgctga 3682981 tggtacttct tatgattctg atattgatgc ttctgtaaac tatgcaactg agacaaaagt 3683041 tgataactct aaaattttga gtgatctaaa tcctaatatt aaagtaacag gtgtaaaagc 3683101 atttgaagtt gacaaggaag cttatgcaaa aggcacttgg aaactaaaat tcagtaatga 3683161 tgttattgtg aaaatcaaat aacagctaac aagggtgcct gtttaggcac ccttgttctt 3683221 taaaaaaggc cttctcaatt gagaaggcct ccattcttat tccgcactct tatacccatt 3683281 cacattagaa gactgccatc tccaggaatc agcacacatt tcctcaaggc cgcgtttcgc 3683341 ttcccagcct agttctcgct tggctttcgc aggatctgca aagcatgtgg cgatgtctcc 3683401 cggacggcgg tccgcaaaac ggtatggaac ctctttccct gacacttttt caaaggcttt 3683461 gaccatttcc agcacgctgt agcctgtgcc tgttccaagg ttgtatgcat cggctcctgt 3683521 agagttcaat actttttcca gcgccttgac gtggccttct gcgagatcaa cgacgtgaat 3683581 ataatcgcgt acgcctgtcc cgtcttttgt cggatagtca tttccgaata cgcttaattg 3683641 ctcgagcttc ccgactgcta cctgtgccac atacggcata aggttatttg ggattccgtt 3683701 cgggtcttca ccgatccgtc cgcttggatg cgcgccgaac gggttaaagt aacgaagcag 3683761 cgcaacgctc cactcattgt cggctgtatg caaatcacgc aatatttgtt caagcatgag 3683821 cttcgtctgc ccataaggat ttgtcgcgcc taatggaaag tcttccgtaa tcggcgatgt 3683881 ttccggaacg ccgtatactg tcgcagatga actgaatacg attttcttga cgccgtattt 3683941 ctccatggcc tcgcataaaa taaacgttcc tgtcaaattg ttatgataat atttgagggg 3684001 aatcgccaca gattcgccga ctgcttttaa ccctgcaaaa tgaatcacag cttcgatttc 3684061 attttcagca aaaacggaat ctaccgcttc ccggtccaat aaatccgctt cgtagaacgt 3684121 taaatctttt cctgtaatct ccttgacacg gttcagcgct tcagctgaac tgttggacag 3684181 attatcaaga acaacaatct cgtagccgct gttcaatagt tcaacacatg tgtggctgcc 3684241 aatgtaaccg gcaccgccag taacaagtat tgccatgatg taaaccctcc taaaaaatga 3684301 cctgttttca ttatatagtg tttagaaccg gtccacatcc atttttaaga agtttaatcg 3684361 tttattaata gttttttcat attttttagc ttaaaccctt gccagcaatt cgatagaggt 3684421 ttcagcaaga atgtgctctt tcatttcttg atagagctca ttcaagtaaa agcccggctg 3684481 aagattcagc tcagcatcta aagcatagac cgtcaatgta tacgcatgat ccttgtcagg 3684541 cggtgtcggc ccgcaatact ggtgaatcac ctttggatcg ttgcttcccg caagcggtga 3684601 agcaaagctg ttttgccctt gtatcatcaa gtcctgtctt tcctcactcg catgttcagg 3684661 aagctctccg atgtaagccg gaatattagc cgctgtccag tgaatccagc tgaatccgca 3684721 tacgggaatg gcgtcatgat cgatgaaagt aagtgcgagc gtctttgctc cggacgggat 3684781 gtcatcaaaa tgaattggaa aggatacaaa tgggtttcct tctctcttat atttttcatc 3684841 cgcgtatttt gaatacttgt catgtaaata tggatttgct tctacgtata tgttcatatg 3684901 aatccctctc tctattttct cgttctatag gtatactaaa cgaatcgatg tataatcagt 3684961 gataaacaaa tacgcatgta aacgtaacaa tttgttatgg ataacttgca gtgaaggaga 3685021 tatttcatgg atttaaaatg gctgcaaacc tttattgccg cagcggaatc agagagcttc 3685081 agggaggcgg ctgagcatct gtatctcaca cagcctgccg tttctcagca tatgaggaaa 3685141 ttggaagatg aactggacat gaggttgttt ttgcatagcg gaagacgagt cgtactgact 3685201 gacgaaggca ggctcttttt gccttatgcc aaagaaatga tccatgttta ccaagctgga 3685261 aagcagaaag tcagtcaatg gaaacagggg tacagccgat cactcacgct ggccgtacac 3685321 ccctacattg cgtcctatat cttgcctcgc tttctgccag cctatatcca aaaacatccg 3685381 catgtcgagc tttcaactca tgtggctgga tctgacgcta ttaaacaagc ggtggaacac 3685441 aatgaagctg atattggttt gtcgcggaaa gacccgaaca ccaacactct ttattatcag 3685501 catatatgcg aaggtacgct ttgtctggcg gctcctttcc aagaaagcag accggatgct 3685561 gcatccgtct taacccgcta tcggctgcta acgcatgatc atccgtcata tggggatgcc 3685621 tttttagata acatccgatc acattacccg tatcttcaaa tgatggctgt cgggcagacg 3685681 gatacggctg tccacatgat gaaagcggga atgggggcat ctttcctccc tacctacatt 3685741 atcaaacagg aagaagccga aaaaaagctg atggctgtca gcacgcctgc acatctagaa 3685801 ttgcctgcgt cccaaacgtt tatgatgtgg aaaagaaaca gcgaagacat tcagcatttt 3685861 cacgccatgt tacatgactt tatgcagcgc gaacaagtat agagctgaaa aatcaatctg 3685921 ccggttgacg tttttctttc ctattttcgc tatgcttaat gcagaaagga tttgatgaca 3685981 tggcgatgag cccttatatt tttattgtat tgattcttat tattttatcg atgtatcgag 3686041 aaagaacggt aaagcccggg aagttgctga tcattccact gttgctctta tggggcgtat 3686101 ctgcatcgtt tcagccggcg tattttcatt ccgtattaca tgtggcgatc agcggcattt 3686161 tattactgat cgggctggcc tgcgggtttg gcattgggaa gatggtaaat gtacggattc 3686221 acccggaaac cggaaaggtc acttcacgcg gctcacttgg gagtgttatc ctcattctag 3686281 tgatactttc tttgcgcatg gccgcgagaa catggctgcc tgagagcaac gagatgttta 3686341 ttgccattat tcattctatg ttcttcgttc ccctcggcac catcacagcc cgcaacatca 3686401 tgctttacaa agcatacaga cgactgaccg ctggcaaagt atccattcaa taaccgaaag 3686461 aaggaccagc atgaacggac aaactccggc tcggcactac tacaagaagc ttgtgccgag 3686521 ccttattctc attttgaatt gcatacaatt tttatctcat ccaactaagg ctgatcccat 3686581 tttgttagca tttgtatttg cggtatactt agcattcatt tggatcattc cctatgtggc 3686641 atccactgct gttagtttga gcatattcat cggactctgg ctcctgaccg atttcttttg 3686701 ggctgtttcc ggccaagagc agggtgccgc ctattttttg attgtatttt taatgatata 3686761 tgccgccttt agactccctt cacggctatc cttgatcttc acagcatgtt taattggagg 3686821 caacatatta ctcctatcct cacaaggggg aagcttgaat accatcatca gcaacatctc 3686881 gatcatgctc ggtctgtacg tcctcttctc ctccatgcgt ttcagacgag aagcgagaag 3686941 ggaggctgaa cggaatcatg ctgaattggc aaaaatgcat gtgcagctgg agcatgctca 3687001 taaagaactc cagaaagcgc atgcagagct gcaggaggct tctgttcttt cattaaggta 3687061 cgcggtcctt gaggaacgta caagaattgc ccgcgacatt catgacagca tcggtcacga 3687121 gctgacttct gtgattgttc agcttcaatc ccttccctat atccttaaaa gcagcaagga 3687181 ggattcagaa aaagtcattc aaaatgtact gagtgtcgcc agggagtgtc ttcaagaagt 3687241 gcggtctgtt gttcaccaaa tgggccgtag tgaatcgatg gtggggctta ccgctttgcg 3687301 ggggctcatt catcaagtgg aggaacggag cggcttgcac gtttctttag atactgccgg 3687361 actgtcagaa gagtcttggc ctccaaacgt gagcgaaacg atctaccgca tcttgcagga 3687421 agcgctgacc aatatcattc gtcacgctga cgcttctcat gcggcggccg tcatttctaa 3687481 tgacaagtcc catctctatg tcacaatcac cgacgacgga caattcaccg gcagccttac 3687541 ttatggattt ggcctgacag gaatgaaaga gcgcgcagaa aaagcaggcg gttcccttac 3687601 tttcagtgcc gtacagccga gcggcctgaa aattgagctg tcattgccgc tcatgacaac 3687661 gaataaggag caaaaagatg aacaaagata aaatacgcgt agcgcttgcc gatgatcagc 3687721 cgcttgtgcg tgaaggcttc cgctacgtca tcaacgcaca gacggatatg acggtttctg 3687781 gcgaggccgg cgacggtcac gatattatag cactcgcaaa acaaacaaaa cccgatgtca 3687841 tcctcatgga tgtccagatg ccgcgttgct caggcatcga agcggcgaaa gacattatgt 3687901 ccgcacttcc aaatacaaag atagtcattt taaccacctt tgacacggaa gaatacgtat 3687961 ttgaaggcat ccgtgcgggc gcagtcggct atctgctgaa ggatacactt cctgaggagt 3688021 tgatagatgc gattcgcgct gcggccagag gcgaggcgat tttccgtaca gtcacagctg 3688081 ctaaaatcat cagtgagaca tttcgggcga aacagcaaac tcatgccgaa gaactggcag 3688141 agccgttcac caaaagagag cttgaggttc ttcagcaaat ggcctacgga ctgagaaatg 3688201 aggatattgc tgaaaagctt ttcgtcagtg aaagcactgt gaaaacccac gtgcaccgca 3688261 tcctgcaaaa atgcaatgcc caagaccgga cacaggcagt cgtttttgcc attcgaaacg 3688321 gtattgtgca atagaaatct ctcatcccgc catgctaaaa taagacaaag gagatgattg 3688381 gaaatgaaag aagaaatcat tgaacggttt actacatatg taaaagtcga tacacagtcc 3688441 gatgaatccg ttgacacttg tccttccaca cccggccaat tgacattagg aaacatgcta 3688501 gttgatgaat tgaagtccat cggcatgcag gatgcagcca ttgatgaaaa cggctatgtc 3688561 atggcaactc ttccctccaa tactgaaaaa gacgtgccga caatcggctt tctcgctcac 3688621 gtcgacaccg ctacagactt taccggcaaa aatgtgaatc cgcaaatcat cgaaagctat 3688681 gatggaaaag acatcgttct taacgaacag ctgcaggtca ccctgtcacc tgatcaattc 3688741 cctgagctgt ccggctataa gggccataca ctcatcacca cagacggcac cacccttctc 3688801 ggcgcagaca ataaggccgg tatcgctgaa atcatgacag ccatggatta cctcatcaaa 3688861 caccctgaaa tcaagcacgg cacaatcaga gtcgccttta cgcctgatga agaaatcgga 3688921 agagggccgc acaaatttga tgtgaaacgg ttcaatgcat cctttgccta cacggttgac 3688981 ggcgggccgc tcggcgagct tgaatatgaa agcttcaatg ccgctgccgc aaaaattacg 3689041 attaaaggca acaacgtaca tcccggaaca gctaaaggaa aaatgatcaa ctctgcgaaa 3689101 atcgcgatga agctgaacag cctgctgccg gcagacgaag cgcctgaata tacggaaggt 3689161 tatgaaggct tctaccacct gctgtcgatt caaggagacg tagaggaaac aaagctccac 3689221 tacattatca gagactttga caaagagaat ttccaaaaca gaaaagaaac aatgaagcgt 3689281 gccgttgaag aacttcaaaa cgaatacggg caagaccgga ttctgctgga tatgaacgac 3689341 caatactaca acatgagaga gaaaattgaa cctgtcatcg aaatcgtcaa cattgccaag 3689401 caagcgatgg aaaacctcgg catcgaaccg aagatttccc ccatccgcgg cggaaccgac 3689461 ggatcacagc tgtcctacat ggggcttccg acgccaaaca tctttacagg cggggaaaac 3689521 ttccacggca aatttgaata catctcagtt gacaacatgg tcaaagccgt aaatgtcatc 3689581 gttgagattg caaagcagtt tgaagcgcaa gcataacgcc aaaagccagt ccaaaaaagg 3689641 actggctttt ttgtgtgaaa atgaaacatt ttaaacacgt cctccgtaaa acaagtatca 3689701 acaaatgagg aggaaaaaca atgacaaaac atgcaatcgc tgccaagagt ctcttgaaaa 3689761 aatggatcat ttccaggccg cttaacatga aaaagaaatc cagcccattt caaaaaatca 3689821 gaaaaatgtt caaacgcttc ttcaaataaa acatcaaatc ccctaaatac aatccgtatt 3689881 cacccgtacc gcccaaatgc tccgtaattt gggttttttg tgttcaattc cgcaaaatag 3689941 ggtataaacc aaacaagcaa gaaaacagca cccaaaaaca ggtaattcga attacgtaaa 3690001 cttaggttaa aagttatata aaggaattta ttttatcgtc gatagtaact atagaaccaa 3690061 tcatcaacaa gagcaaacag cgtaattcaa gactattttc aggtcatcag gtaatactgt 3690121 tttagaggga cagtttcttg ttatttattg atttagaatt ttttgaatac tttttggcat 3690181 tttatccgta caatagagag taccaaaact ttttttggga ggtatgtaat atgatcctat 3690241 ttattatcat cgcattatgc ggctatcttc ttttttcttt cagcaaggac aatcgccgca 3690301 aaccgcaaaa gacaagccct ctgccagcag ccgcacctca tcacaacaac ctaatcgacc 3690361 ttgacgccat ccgccaaaaa cgccggatgc atctttccta attctatatt tcaaacgaaa 3690421 aggctgctga atcacgcagc cttttaaaat tgttttgatt tagagcctga aaccttttcg 3690481 ccacctatcc gtaatttcat acaaggcaaa cccaaaggag acttcagcaa tgatcgagtt 3690541 atttatgaaa caaaaaatgt tctcatttaa agatgcattt cacatttatg accgggatga 3690601 acaagaaaca ttcaaggtgg aggggcgttt tttctcgtta ggagactcat tacaaatgac 3690661 agactcatct gggaaaacgc tcgtttccat agaacaaaaa ctaatgtctt tattgccgcg 3690721 ctatgagatt tcaattggcg ggaaaacagt ttgtgaggta acgaagaaag taacgttttc 3690781 caaaccgaaa tttgtgattt ccgggcttaa ctgggaaata gatggtgatt tatggaggga 3690841 tgaattccaa ctgacggacg gggaaaatgt ccggatgtca gtgagcaaaa agtggctcag 3690901 ttggggtgat tcctatcact tgcagattgc atacgaggaa gatgttctga tttgcactgc 3690961 catcgctatc gtgcttgata tggttttata taacgatgaa gatgaaagta ttttctaaaa 3691021 agcattgaca attgatccaa aagtaataat attaagataa ttgaaatctg aatatgaagt 3691081 tgtaccttat caagagaggt ggagggactg gccctatgat acccggcaac cgctgtttca 3691141 aacagaatgg tgctaaatcc ttaagaacat tgcgttcttg cagatgaggc ggagatttga 3691201 tcgttcaagc tcttccttac acaaaggaag agctttttac atgcttaata tttcagaaaa 3691261 gaggcgaata acatggctca acaaacgaat gttgcaggac aaaaaacaga aaaacaacgc 3691321 aaagcacctt tccgcgccga tcatgtcggc agcttgcttc gttccgttcc ggtaaaggaa 3691381 gcccggcaaa aaaaagcggc tggtgagatg acagcggaac agcttcgtga tatcgaaaat 3691441 caagagatca cccgcatcgt ggaaaaacaa aaagaaatcg gtctcgatgt ggtaacagac 3691501 ggggaattcc ggcgttcctg gtggcattat gacttcctgg aagggcttga cggtgtggaa 3691561 ccgttcatcc cggctgaggg gattcagttc cataacacaa aaacgaaagc gcgcagcatc 3691621 aaagtgacgg gaaaactcga ttttacgagc cacccagcgc tcggtgatta tcaattttta 3691681 catgagattg ccggtaacgc gacgccaaaa ttgaccattc ccagtccaaa tatgctgttt 3691741 tttggcgaaa aggcggataa agggatttat gacgatcaag aggaatactt tcatgatatg 3691801 gcccaagcgt acaaaaaagc aatcaaagcc ttctatgatg ctggctgccg ttatctccag 3691861 cttgatgata cgtcatggtc tctcttcttt gaggacaaag gcagagaggt tgtccgggcg 3691921 ctcggcggtg atccagaaac attgccagcc atatttgcca aaacaattaa cgatgccgtc 3691981 gcagaccggc ctgacgattt aacgatcaca atgcacattt gccgcggcaa cttccgctca 3692041 acctgggcgg catcaggagg gtacgacgct gtagcggaaa cgattttgga cggcttaaac 3692101 cttgacggcc ttttcttgga atacgatgat gaccgctccg gaaactttga tccgctccgt 3692161 tttgtgaagc gcaaggatct gcaaattgtg ctcggcttga tcacatcgaa atacggcgag 3692221 cttgaaaatc ctgaggatgt gaaacgccgt atcaatgaag ccgcgcgttt tgtcagcttg 3692281 gaccagctat gcctgagccc gcagtgcggt ttcgcctcta cagaagaagg caaccttctg 3692341 acagaggagc agcaatgggc aaagctgcgc catgtcatcg acattgccaa cgatgtgtgg 3692401 agataatcta tcattgacag aaatagaaaa tgtgtgaata atagatacta tcagaaaatt 3692461 taataaaaag gttttcctta tcaagagagg tggagggact ggccctgcga tacccggcaa 3692521 ccgctgttta acagaatggt gctaaatcct ttagagcaat gattgctctt gaagataagg 3692581 ttgagattgt cacgcaagct cttccttatc caaaggaaga gcttttttat atttgaatgg 3692641 aaagaaggaa tggacaacat gtcacaacaa acaacacccg cagaacaaaa atcacttcaa 3692701 agaaaaaaac cgccgtttcg cgcggatcaa gtcggaagcc tgctaagatc tgagcccgtc 3692761 aaaaaagcgc ggctgcaaaa agcggccggc gaaatgaccg ctgagcagct tcgccaaatt 3692821 gaaaacgacg aaatcatccg cattgtggaa aaacagaagg aaaccggcct gaacgtcgtg 3692881 acagacggtg aattccgcag agcatggtgg cactttgatt tcctggaaaa cttagatggc 3692941 gttgagccgt ttactcctga gcaaggcatt caattccata acgtacagac aaaagcacgc 3693001 ggcattaaag tcacaggcga tatcgacttt tcaactcacc caatgcttga agattactca 3693061 tttctccata gcattgccgg tgacgcgacg ccaaagatga cgattccaag tccgaatatg 3693121 ctgtttttcc gcggaaaact ggaaaaggat gaatacaaaa acgattatca acttttccag 3693181 cacgatgtat ccaaagcata taaaaaagcg attcaagcgt tttatgacag aggctgccgc 3693241 tacctccagc ttgatgatac agcgtgggcc gttttcttat cagaaaaagg cttaaaacaa 3693301 atcgaagcgt tcggaacaac gcctgacgag cttcgccagc tgtttgcgaa atccattaac 3693361 gacgcgattg cagaccgccc ggatgacttg acggtaacca tgcatatttg ccgcggcaac 3693421 ttccagtcca cttggacagc ggaaggcggc tatgacgcag cagccgaaac catttttgac 3693481 ggcttgaatc ttgacggact tttcttagag tatgatgatt cacgctcagg cggatttgag 3693541 ccgctccgtt acgtaaaacg gtctgatctt cagcttgttc ttggcttagt gacatctaaa 3693601 ttcggtgagc ttgaaaatcc ggatgacgtg aaacgccgta tcgaagaagc gtcccgttat 3693661 gtaagcttag accagctttg cctcagccct caatgcggat tcgcttcaac tgaggaaggc 3693721 aacaagctga ctgaagaaca gcaatgggcg aagctccgcc atgtggttga gatcgctaat 3693781 gatgtttgga aataagcaaa gaaaaaaaca cacttgattc cctagcggag caagtgtgtt 3693841 ttttatgtca ttgtgcggtg tagcccccat caaggacgac agcctgccca gtgacgccct 3693901 tcgccttctc gcttgccaaa aacacggcat aatccgcaat ttccttgacg gaaagcagtc 3693961 gcttttgcgg cacaagcgga aaaatgactt gttcaagtac agagtcgtaa gggacatttc 3694021 tagttttcga tagatcgcta agctgattgc gtacaagctg ggtatcgaca taacccggac 3694081 agagcgcatt gactgttatg ccgtggggcg cgccttccag cgcccctact tttgtgagtc 3694141 caatgacgcc gtgcttggcg ctattataag cggatttccc tgcaaagccc actaatccat 3694201 taacagacgc aatattaatg attctgccaa actgctgttt tttcatgatc ggaaaaacat 3694261 gcttcattgc aataaaggga gccgtcagca tgaccttgat cagctgttca aaggtgtctg 3694321 tcggaaactc ttcaatcgga gcgacgtgct gaataccggc attgttcacc agaatatcca 3694381 agcggccgta ttgtttttgg atgacgttca ccgtatcagc aacttgcgct tcctttgtca 3694441 catcatacgg aatggccgcc gcgtcaaagc cttcttctgc aagcttggag gctgcttttt 3694501 cacatgcttc cggacggagg tctgaaacga tgacgctggc accttcccgg gcgaattctc 3694561 ttgcgatttc gaatccgatt ccgccggcag cccctgtcac caaagcgact tgttttctca 3694621 tgtcaaacac cttcccatta agaattgagt acagactggc ttacagcgaa atcagcttct 3694681 gttttttcat aaacctcttc aattgtgaca ccatcctgaa gctccgtcag tgtcatgcgg 3694741 ccgttcacaa aatcaaatac agccaaatcc gtaatcagcc tgtgtacgac tttctggcct 3694801 gtcagcggaa gggagcatgt ttttttcacc tttgattcac catgcttatt gacgtgctcc 3694861 atgatgacaa cgattcgttt cgccccgttg acgagatcca tggcgccgcc catccctttt 3694921 accattttgc ccgggatcat ccaattggcc aaatccccct gctccgaaac ctccattccg 3694981 ccgagaatag ctaaatcgat atgcccgcct cttatcatcg cgaatgactc agcgctgtca 3695041 aaataagagg cgcctgtcac ttcagtgatc gtttcctttc ccgcattgat caaatccgcg 3695101 tcttccgttc cttccagagg ataggggcca attccgagca agccgttttc cgactgaagc 3695161 atgacgtgaa cgccatcggg tatctcattt gcgacaagcg tcggcattcc aatcccgaga 3695221 ttcacattca tgccgtcctt gatttcttgt acagcccgtt tgaccattcg ttttctcgct 3695281 tccttcactt ggcctcaccc tttcccgatg cttgctgaac tgttcgtttt tcaatccgtt 3695341 tttcttggct cgcgccaagc acgacatgct gtacgtaaat tcccggcgta tggatgtgat 3695401 ctggatcgag ctctcctgct tccacgattt cttccgcctc ggcaatcgtg atcttgcctg 3695461 ccatggcggc aatgggattg aaatttctcg ccgttttcct aaaaatcaaa ttgcccatgg 3695521 tgtccgcttt ccacgctttg acgatcgcca catcgccggt aatgcctcgc tccagcacat 3695581 aagtccggcc gccgaatgtt ttatgttctt ttccctcggc tatggaggtg ccgacgcctg 3695641 tcgccgtata aaatcccggt atgcctgcac cgcctgcacg aattctctca gcgagcgttc 3695701 cttggggaac aagctctacc tcaagctctc cgcttaaaaa ctgccgctca aaaattttat 3695761 tttcaccgac ataggaagcg atcattttct tgatttgctt gttagccaga agcaaaccaa 3695821 gcccccagtc atcgactccg cagttattgc tgacaacggt taaatccttt actccctgat 3695881 ctcttataga caaaatgagc tgttcaggga tgccgcacag cccaaaccct cccgcgatca 3695941 gcgtatcccc atcatgaatc agtttcgcag cttccttgct tgatgacagc acttttccca 3696001 tattgatgcc cctttcgttt tcttctacac tagaccagtc aggctgtaaa tcgcgatcac 3696061 agcaaatacg gcagccgttt taatgagcgt gatcgcaaaa atatcgcgat aggattgccg 3696121 gtgggtcaaa cccgtcacgg ccagaagcgt gataacggcg ccattatgcg gcagtgtatc 3696181 catcccgcct gatgccattg aaatgacccg atgcatcacc tctggcggaa tattgtaagc 3696241 ctgaatcgcc tgtaagtatt gttctgacat cgcgcttaac gcaatgccca ttcctcccga 3696301 agccgagccg gtgattcccg ccagcgcagt tgtcgtaacg gcgccattta caagcggatc 3696361 ggtaaaagta tgtgaaattc cgctgctcag cttatgaaac cccggcagcg cggcgataat 3696421 gccgccgaac ccgtactcag cacccgtatt catagatgcc agcaaggcgc cgccaattcc 3696481 ttcattcagc ccttccttca attgggcaaa cacacttctc caatcaaata atatcgttgt 3696541 gatgatgcca atcactaaag caatctccac cgaccaaata gcagccgctg aagaaatatc 3696601 aagcctgccg aactccttta atcctatgga agaaaaatca aatccattcg gataccactt 3696661 tggcaggtaa atggtgaaat atttattcac tgcaccgacg agaataagcg ggacaaaggc 3696721 aagcgcgtgc cgaatcgggc ttttgtccgg ttcagccgcg gactcaatcg attcaggagc 3696781 aggagcattc tgcgaatcaa aaccgccata gccttcgcca gatgcctgcg ctttcttccg 3696841 ccttgattcc aaatagagca tcccagctgc cagcacaatc actgcgccca tcaaacccag 3696901 ccaaggggcg gcataaatgt ctgttttgaa aaacgacgtc gggatgacat tttggatttg 3696961 cggcgttccc ggaagtgcgt ccatcgtaaa cgtaaaagct cctaaagcaa tcgtacccgg 3697021 gatgaggcgt tttggtatgt ttgcttcttg gaacatgttt ttcgcaaaag gatatacagc 3697081 aaatacgaca acaaacaggc tgacaccgct gtacgtcaag acagcaccca tcagcacaat 3697141 ggcaagtatc gctctttttg ccccgacaag ccggacaatt gttttcgcga ttgatgccgc 3697201 aagcccggcc atttcaacga cctttccaaa aatagcaccg agcaaaaaca ctgggaaata 3697261 cagcttaata aaacccgcca tcttctccat aaaaattgat gaaaaaaaag gaagcacatg 3697321 gcttggatct gtcagcagca ccgcgaataa cgcgcaaatc ggcgcaaaca atatgacaga 3697381 aaatccccga tacgccgtaa acatcagcaa acctaacgcc aatagaatga tgatcagttc 3697441 cacacacaca tcccccgttt ccgcgaacta gaaagcgttt acaaaaacct gtccgcatcg 3697501 gctgtttccg tcccctttcc atatgtacga gaagcgtggg ccaactattc cgattaaaaa 3697561 aggaaagctc cttttttcgg agctttcctc taccattcat ttcattccta ttaggatatc 3697621 aacatcaacc gtaatatcgg ctgatttcat ctctttcagc aggctgactc gatctttcgg 3697681 cgccgaccag gcaagcggcg tcatcttgag aagccagtgg atcgcctgct ggtcaagcgt 3697741 tttaacatag cgcagcctga caggacggct gtgtgctgca tttgctgtaa aacgctcaac 3697801 tgctgccgta ttggaatacg tgcgccttgg tgaatcagta tataaaaatt gccttaattc 3697861 tattaaatag tcgcttcgcg gcactacttt tatgagcatg ccatcattct tcagcagtct 3697921 atgaaactct gcataattgg acggcgaaaa aatagacaga acaacatcaa attggcgatc 3697981 atgaaaagga gcacgcgcca catcggcaac cgcccacatc agatctttga atgccttaga 3698041 agcttttaag atcccgtcct tcgaaagatc tatgccggtt cctatcgctg ctttccctgc 3698101 ataatcaaac ccgcaaagcg cattcaaatg agaaccctca ccgcaaccgc tgtccaagat 3698161 ggtgaatgcc tcatgaccag atttgggatg actgatgagc tctgcaatcg catcatggag 3698221 cgggtcaaaa aaaccacatt ctccaatcag cctgctcctc gcttcaaaaa gctcggcacc 3698281 gtaactggtt ttgaccggct tcgtcagaaa gttcacgtag ccgtgccgag atagatcaaa 3698341 tgtatgtcct cgttctgtac aaatcaagct tttccctgat gccgcatcca tagaagaatc 3698401 gcagagcggg catcgaaaca tgctgaaatc aactgttcgc ttcatgataa aaaacacccc 3698461 attcattcat ttttagataa atgaaaaagg catagacaaa taaacctagg cctatctcaa 3698521 aaattggcca ggtctggcag tttgtctaca cctgtcatta tctataacga atgaattgga 3698581 taatcatgaa aaaaactccc tttctgctgt atgggtttcc ccgtttccat catacaacaa 3698641 atatccagga gctggaacct tatagtgaag aaaaatcagt actgacatgc tggtatcccg 3698701 ccaacatcat atcagcatag caatccagca tgtttttcct ttattttctc attttagaat 3698761 ataaatttta ttattgtgaa aatagttaaa aaggttgatt ttcaaaaagt gaaaggataa 3698821 aatactgcta tcatcttaga aaaagacatt cttgtatatg atcagtaata tggtctgatt 3698881 gtttctacct agtaaccgta aaaaactaga ctacaagaaa gtttgaataa atttgaacga 3698941 gttgaaaagg acaagttctt ttctgtttgc tcttattttt cacactttct gcacttccag 3699001 aatttgtgaa ggataagagc tttttttgtt tccataataa ccctcatagg agttgctatc 3699061 atgtactttt tactaaacct tgtcggtctc attgtgatta tggcagttgt attcctatgt 3699121 tctccgcaga aaaagaaaat caagtggcgc ccgatcatta cgttaattgt tctggaattg 3699181 ctgattactt ggtttatgct gggaacaaaa gtcggaagct gggccatcgg taaaatcggt 3699241 gatttcttca cttggctgat tgcttgcgcc agtgacggta tcgcgtttgc ctttccgtca 3699301 gtgatggcga atgaaacagt agactttttc tttagtgcgc ttcttccaat tatctttatc 3699361 gtcacattct ttgatatttt aacgtatttc ggcattttgc cttggctgat tgataaaatc 3699421 ggatgggtga tttcaaaggc ttcccgcttg ccgaaattag aaagcttttt ctctattcaa 3699481 atgatgttcc ttggaaatac cgaagcactt gcggtcatcc gccagcagct tacggtttta 3699541 agcaacaacc gcctgctcac attcggttta atgagcatga gcagcatcag cggctccatt 3699601 atcggatctt atctttcaat ggtgcctgcg acatacgtgt ttacagccat tcctttgaac 3699661 tgcttaaacg cgctgattat cgcaaacctg ctgaatcctg ttcacgtgcc ggaggatgaa 3699721 gatatcatct atacaccgcc taaagaagag aagaaagact ttttctctac gatttctaac 3699781 agtatgcttg tcggcatgaa catggttatc gttattttgg caatggtgat cggatatgtc 3699841 gcattaacgt cagcagttaa tggcattctt ggcgttttcg tacatggcct gaccatccag 3699901 acaatttttg cttatctgtt cagtccgttc gcattcctgc ttggactgcc agtgcacgat 3699961 gcgatgtatg ttgctcagct gatgggcatg aaattagcaa cgaacgagtt tgttgcgatg 3700021 cttgacttga aaaacaatct caaatccctt ccgcctcaca ccgttgcggt ggcgacgaca 3700081 ttcctgacgt cctttgcaaa cttcagtact gtcggcatga tttacggcac gtacaattcg 3700141 atccttgacg gagaaaagtc aacggtcatc gggagaaacg tgtggaaact gctcgtcagc 3700201 ggaattgcgg tatctttatt aagtgctgcg attgtcggcc tgtttgtgtg gtagaaacat 3700261 tgagccatat cccttttcgg atatggctct tttcattatt gataaataga ggctggcacc 3700321 tgcacatccc ggattcccgc tgcataaggc cccaagtcat actggccgaa gacgatggcg 3700381 atcccgtttg ccgtaaagta aaacattgtg tctctgttta gggttatatc ctctttcttt 3700441 acatcagaga aaaacagcac atcgtgtttt ttgatatagc tatataggta atctctcgtt 3700501 ttgctgactt ttgttttggt gttcagaatc tgatccagcg tcacccgctt ttgtgctttc 3700561 aagtcatagt tgaaggactg gacagacgtt agaccgtggg cgccccctga atagatataa 3700621 ttgagtgttt gaatgctgag cttgcctgcc gcattgtatt tgacgctgaa ggatgtttga 3700681 tattcccgtt ttaaagccct gctgttcgcc tgcttttttg tttttcaggt attcctgata 3700741 cgattgttca tgtaggcttt cagctcttga ttgattttct tttcaaacgc ggcattcccg 3700801 acgtgatgca cttgtggata cgttaactcc ttgatctttt tgtacgtatg ggtgctgaca 3700861 gtcggtgttt tcgcttgaac tgcttttaaa gatggggccg catatgcaaa tacagaaaaa 3700921 agcaagactg caatgcccgc ggctttcagc atgttattcc atttcataca atctactcct 3700981 ttgatgtcgt tgtttatcat tcccttattt aagcaataca cacttttata gactgattaa 3701041 atcgaaagaa gtttctaggt ctaacagcat gatttttcca ataaaaaaag agacacagga 3701101 tgtctctttt tttactgttt gcgcccagaa atcgcttcat gaagggcttg tgccaaatct 3701161 gtatttccga acatctctaa taccgcaatg acagtctggt ccggaatgtg ctctgcttcg 3701221 tgttttggca cgaccagatc gtccatggtt tttttcaagc tttcattcag cttttgctgc 3701281 ggatacgctt tggcgtacag ctccatcgga tcaagatcat ggttcacgca ccactgggca 3701341 aacaccaaaa tcatcatatt ttcatcgcgt tcgtaagctt cagtgagctg tttttcgttc 3701401 atttgtcatg ctccttatga aaagtatctt ccttaaagat acaggagccg atcaaattcg 3701461 tctatcccaa tggcgatgag cagcaaccgc atcgataaat gccttgctga aagcggtgta 3701521 gtcaggttca tctttagccg ttacgatgcc tagcccctct gttgtcccga cagaggattg 3701581 aagaaggtca attccttcat ttgccgcacc gatcgccttg tagtgattgt aagcttctct 3701641 gataaacgcc atcgcttgtt tgttgtcttt taactccagt cctcctgcgg catagacggc 3701701 atcatacaga acagaatcaa ccgtcaggaa cgtgccgctg gcctcaagct gctgtccgct 3701761 gccgcttgtc atatacccca gattttgact gatgatatcc actgtgattc cttcttgctt 3701821 taaggcttcc agtactgttt gcagctcttt ttcatgaaat ccgtttccgg cgagtacagc 3701881 gacttttctt gttgacgcgg ttttcactgt acgggcttgg cttaacgcag gcgaagtaag 3701941 aatttcttta gatgctttac gcttcgcggg cgccgccacg cctactcctt tggcgatttc 3702001 ttctgctaaa tctgcatcga cattgctgaa gacatcaacg acctgccgct gtacgtcttt 3702061 gcttttgacc ttcccgacct cgaagcagaa agcagaaatg atgtgctgtt tctccacagg 3702121 agacatgctg ttccagaaaa gcttcgcctg tgagtaataa tcgttgaagc tgtcgcttcg 3702181 ctggcggatt tttttgccct cgactttttc ctgatagtgg acgtagccgc cttcttcagc 3702241 tgtcgcaggc gacggatcat tgttttgcag tgagttttta tgataagcga caggtccctt 3702301 attgatcgtc atccggtgat agccgtcgta ttggttgtta tggaatggac agaccggccg 3702361 gttaatcgga atctcatgga agttcgggcc gccaagacgg atgagctgtg tatccgtata 3702421 agagaaaagc cgcccctgca atagcgggtc attggtaaaa tcgatgcccg gcacgacatt 3702481 tcccgggtgg aatgcgactt gttctgtttc cgcaaacaca ttatcctgat tgcggttcag 3702541 cgtcattttt ccaatgatct tcaccggcac aagctcttcc ggccacagct tagttgggtc 3702601 aagaatatca aaatcaaact tgaattcatc ttcctcatca atcatctgca cgccgagctc 3702661 gtattcaacc ttgccgccgt tttcaattgt ttcccacagg tcacggcggt ggaaatctgg 3702721 atctttcccg gcaatttttt gcgcttcatc ccatacgaga gaatgcacgc cgagcaccgg 3702781 cttccagtga aatttcacga aacgtgcctt tccttgttca ttgacaaaac ggaacgtgtg 3702841 aacgccgaag ccttccatca ttctgtagct gcgcgggatg cctctgtcag acatcgtcca 3702901 catcaccatg tgggcagact cagggttatt ggcgacaaaa tcccaaaatg tatcgtgagc 3702961 agtcgcagcc tgaggcattt cattgtgtgg ctcaggctta aacgcgtgaa ccaaatccgg 3703021 aaatttgatt gcgtcctgaa tgaaaaacac cggaatgtta tttcccacaa ggtcatagtt 3703081 tccttcttca gtataaaatt ttgtcgcaaa gcctctggca tcccgcaccg tgtctgcgga 3703141 gcctttagaa cccgcaaccg tagaaaaacg gacaaatacc ggtgtcttca ccgaagggtc 3703201 ctgaagaaat ttggcccgtg tgtattccgt cattggttcg taaacctgaa aaaagccatg 3703261 cacgccaaat ccgcgcgcat gcacaacgcg ctccggaatc ctctcatggt caaagtgcgt 3703321 cattttctcc cggaaatgaa aatcctccat cagcgtcggg ccgcgaaccc cggcttttaa 3703381 cgagtgctca tcctctgaca ctcgcaagcc ttggtttgtc gtcattttct tcccgctgtt 3703441 atcggtcctg tactgctcaa gctgctcgtc ctttgagtgt tcatttacac gtttgttttg 3703501 gtcatcactc atgtctgctc ccccttttta aaacgaaaca ttctacagca catttacccg 3703561 tggcgttctt catataaact gctaatccgc tcattaggat ttttggtcta catataaata 3703621 tgcggtcata cacatttgaa ataagccttc ttcacagaaa gaaaggatgg aagcgcttac 3703681 caaaaaagct gttgaatagg ggaggtcata tcatgcttgc catactcggt tttgtgatga 3703741 tgattgtctt tatgtacctt attatgtcta accggctttc cgctcttatt gctttgattg 3703801 tcgttcctat tgtgtttgcc ctgatcagcg gatttggcaa agatctcggc gagatgatga 3703861 ttcagggcgt tacagacctc gcccctaccg gtatcatgct gttattcgcc atcctgtatt 3703921 tcggcattat gattgactca ggcctgtttg atcctctcat tgccaaaatc ttatcgtttg 3703981 tcaaaggaga tccgttaaaa atcgccgtag gcacagcggt tctgaccatg accatttcgc 3704041 tggacggaga tgggacaaca acctatatga ttaccattgc agcgatgctg cctctctaca 3704101 aacggctcgg catgaaccgt ttggtgttag cgggaatagc gatgcttggt tcgggggtta 3704161 tgaatattat cccgtggggc gggccgactg cgagggtttt ggcttcctta aaattggaca 3704221 cgtcagaggt ctttacaccg ctgattcccg ctatgatcgc cggcattctc tgggtgatcg 3704281 ccgttgctta tatcctcgga aagaaagagc ggaagcggct cggcgtcatt tcgattgatc 3704341 acgcaccgtc ttccgacccg gaggccgcac cgctcaagcg tcccgctctt caatggttta 3704401 acctgctgct gactgtcgct ctgatggccg cactgatcac cagcctgctg ccgctccctg 3704461 ttctttttat gactgcgttc gccgttgcct tgatggttaa ctatccaaat gtcaaagagc 3704521 agcagaaacg aatctcggcg catgcgggta atgcgttaaa cgttgtctca atggtgtttg 3704581 ctgcgggcat attcacaggc attctctccg gcacaaaaat ggtggatgcc atggcgcatt 3704641 ctctcgtttc actcatccct gatgccatgg gcccgcacct gccgttgatc actgcgatcg 3704701 tcagcatgcc cttcaccttt ttcatgtcga atgacgcctt ttacttcggt gtccttccca 3704761 tcatcgccga agccgcttcc gcttacggaa tagacgccgc tgaaatcggg agggcctcct 3704821 tgctggggca gcctgtgcat ctgctcagcc cgcttgtgcc ttccacctat ctattggtag 3704881 gaatggcagg cgtcagcttt ggcgaccatc aaaaattcac tattaaatgg gccgtgggaa 3704941 caacgattgt gatgaccatt gcggcgcttt tgattgggat tatttctttc taaatgtatg 3705001 agcttgatcg tagcattgag tgagtacgtg atttacagag gggagaagat caaataggat 3705061 attatgagtg aatagaagat tcatgccaac aacttctcat tacaatcata agagcctgct 3705121 atattgcagc aggctctttc acatttggca ttattttttt gtatagcgca cccagtcata 3705181 atgagcgtat agcggattta caccattgta ggagccaagc cattcatcga cacccgtgcc 3705241 attccacaag ttcatcatga tctttccagg tgttgtcgga atttggtttg ttgcagtatg 3705301 ttttaattgc ccgtcgacat accatttaat agagtttggc tgccaatcga atgcatacgt 3705361 atgataggca ttggctgcat caaacccgag atcaacaatc ttctcatggt ttcctgcacc 3705421 atttgtataa tagttaaatt gaaccttcgt tgtgtctttt cctaaaaatt cgatatcaat 3705481 ctcatcccaa ggagttccat ctgttggacc tgtgtaagtg aagaacgatg aaacgatccc 3705541 tgtgttttta gctggtttca ttctgacttc ataaagtcca tagccatatg tttgaacaga 3705601 acggttttcc ccgcagtcaa acttgttata agctgggctt gttagcgcta aacgcatttc 3705661 acccaatgac gtcattgata cgttattagc ccgccacgtg cagttgaaca tatttccatt 3705721 cgaataacca tctgcttttt gccaaaaacc ggagttatag ccgttaaaag ggtcaaaaaa 3705781 cgatccacct gtttgagctg aggcagtagc agtgactgca aacaaactca taaacaatcc 3705841 agtgacaaga agcagcaaca ctcgtttcag ataaggcata ttggcattcc cctttcattg 3705901 aaagcgtttt ctatgttgat cttacatgat tcttttaaaa gggaacatcg gtcaaaataa 3705961 tgataatatc gaatcttact aacttgaatc ctgtaactat catcatcttc cctctgaaaa 3706021 aaataaaaac ctaaattacc atcagcacag acagagatga tccgcactca ttgcaattta 3706081 ggttttgcct gctttatcag taacaatcct accattttca tatgtgaatg taagaaaaag 3706141 tgaacacaag gaaacacaaa tgtcagcgct ctcattatgc ttgtttaact accctttcta 3706201 tgtgaatggt taaatacagc agctcgtcac ttgtgagctt gtgctcatac tcccgctcaa 3706261 tgtaggtttg gattttcttc gtgcattcat acgcgcgatg atacttttct ttcactgtat 3706321 ccagcaaaaa atcgtcctgg ctttccatgt gagtgccgtt aaatagacgc tgcgcgaaaa 3706381 actttaagtg ggtgacgaac cgataatagt gaagcgattc ttcgttgaat tcaatcttaa 3706441 aatggtattt tacaatactc aaaatctctt gcatgacttt tgtaatgttg ataatattgg 3706501 gcatctcttc attcagctcg gcatttacaa tatgcagagc aataaagcct gcttcatcct 3706561 ctggcagaga cacaccagtc ttgtttttta ccataaccaa cgcttctttg ccgatcgcaa 3706621 attcgtcttt gtagagccgt tttgtttccc acagcaaggc gtttttgata tcaagccctt 3706681 tctggttgcg ctggatggca aagttaatat ggtcggtcag cgacacatag atgctgtcgt 3706741 tgagcttttt gccgagctgt aattttgcgt agctgataat ctcttcggat acttccatac 3706801 actcgatcgg tatatcatac aaaagggttt tgaacttttc tgatacatcc ttgttatcga 3706861 gcgtgaacac tttctcaatg cgggcttcat cgacatcatc gccggacttt ttctgaaacg 3706921 cgagccccct gcccatgacg accaattctt tcccctgttc attgaccacg ctgatcacat 3706981 tattgttgat caccttcgca attttcatgg catgtccctc caaatctact aagaacagac 3707041 tatatcttga ttgtacattc tttttgtact aggtcaatat catcagggaa agacggaagc 3707101 tggtcagtac aattcactcc gtacctgctg cccgggctgt ttttgaagca gcgcctccag 3707161 atggcgttca aatgatgcct tgtcagcttt ctgctttttg acaatgctgt tcatgatttt 3707221 aatgctttca gcactgtatt gtgtatattg ttttttcagc tgatccagct gctgtcttgt 3707281 cttcttcgcg tttttcggtg tgacttggtt gatgagtttg atcatactgt ctgcggtctc 3707341 aaaaaaaccg gctctatttt ctgtcagctg ctgaatttcg atgcggctca tatcttgatt 3707401 acgcgttttt tgaagcaagg caaccgcctc gctgttttgt tttttgagcg atttgttctc 3707461 aagcttaatc gattcgagat tctccttcgc aatgtctgct tcttcttcag tcatgctgat 3707521 tcgcacgaag tattctggat tgccgattcc ataatcaaat gcttcgctca cttgtatcat 3707581 ggaactgaac acaatggcca gctgcctgtc gcttgcgagg gcttggaaat cctgcttttt 3707641 cttactgctc atcggtttgg ctgcggtttg ttttactgtc ttttgatcac agtctgcgaa 3707701 catctgagcc tcaccttcac tttcgcatgc gctcatcaca agaactgtga ccagcaggct 3707761 tatacacaag cctattcgcc tcatgctctg tctcctctct gctgaatccc ttctggaaaa 3707821 taccataaaa tatagttaaa tggtaccaga tgcacctaac cccagcaata aatcaaaagt 3707881 atgatttgaa gcgaaaaaac ataaatattt tgtaaaaatt gacgtgcatt ccattctttt 3707941 caggcccatt tctcgtacaa tagaagtatc gttaccggag aggggctctg atgatgaaac 3708001 gttttacgaa acaagaaaac agctgggtgt tatatgactg ggcaaattca gcttactcaa 3708061 ttgtcgtgac caccgcggta tttccgttat tttataaatc agcagctgcg gaaagcggtg 3708121 tcagcgccgc tcaatcgact gcctatctgg gctataccat tgcgatttca acgtttattc 3708181 ttgcgatgct cggccctatt ttaggcacaa tcgccgacta tgaagggtgc aagaaaaagt 3708241 tcttcggttt ctttgtgtca gccggtgtcg ccagcaccgc gatgctcgcc tttatcccta 3708301 gtgaacattg gctgctattg ttgctgtttt atacggtatc ggctatcggt ttttccggcg 3708361 ccaatgtgtt ttatgatgcc tttctcgtgg acgtcacgcc tgagaagcgg atgaatctcg 3708421 tctcggcacg gggttttggc ttaggataca ttggaagcac gattccattt atcatcagta 3708481 ttgctgtcat cctgctcgca caagcagaga ctattccagt gtctgtatcg gccgcaagcc 3708541 agctgtcctt cttcataacg gctgcctggt gggggctgtt caccatccca atgattaaac 3708601 atgtccatca acgctattac atcaaaaaag aacctcatat tgtcatcaac agctttaagc 3708661 ggctcggcca aacgatgaaa cggatcaggc aataccgggc acttttcctc ttcttgctcg 3708721 cttatttctt ttatatcgac ggagtcggca cgattattac gatgtcgaca tcctatggat 3708781 cagatttagg gatcggctcc tcaagccttc tgatcatcct atttgtcacc caggtagtcg 3708841 ccgcgccgtt ttcgattata tacggaaaac tggcagaacg cttcacgggg aagaccatgc 3708901 tgtacgtcgg gatcgtcatt tatatgatcg tctgcgtgta tgcctatttt atggagacaa 3708961 cgcttgattt ctggatactg gctatgcttg tcgccacctc gcaaggcggt attcaagccc 3709021 taagccgttc ctatttcgcc aagcttgtgc caaagcgcca cgccaatgaa ttctttggct 3709081 tctacaacat ttttggaaaa ttcgcctcaa ttatggggcc gctgctcatt gccgttaccg 3709141 cccagctgac cggtaaatcc tcgactgcgg tgttcagcct gatcattttg tttgtgattg 3709201 gtattgtgat tcttgccttt gttcccgagg aaaccagcac agatgtcagc cagcagcaaa 3709261 atgacctgcc cctttaactg ggagcaggtc attcatcatt tattcgcttt attcaccttc 3709321 agctgtttcc ctttgacggt tgtgttcttc atcactttga gaacatgagg gcctttacca 3709381 tttaaaatct caacgtatga ggcgttatcc atgatcgtga tgatgccgat gtcgtcagct 3709441 gacacaccgt caattttggc aatcgttcct acaaaatcaa cggctctgat tttctttttc 3709501 tttccgccgt taaaatacag cttcataatg tctttattca gctcttcgct tttgtccttt 3709561 ttgctttccg gacggtcatt cagtttagct agaaattctg gtttcttcct tgccacttcc 3709621 tcttgagaag gtgcttctat tttttggatt tcaaatccga tatattcttc aatgtcggct 3709681 aaaaaccgtt tttcgaaggc cgtgacaaac gaaatggcct ttcctttgtt ccctgcgcgt 3709741 cccgttcggc ccgtgcggtg gacatagctt tctttttcaa gcggcagatc atagttgatg 3709801 acaagggaga tattttcaat atcaatcccg cgcgcggcga catccgtcgc cactaagtaa 3709861 cggtactcgc cacgtttaaa ttcattcatg acgtcgaatc ggtcttcctg aatcattccg 3709921 ccgtgaattt tatcgcatgg atatcccaag tcatccaatt catcggtcag ctgattgacg 3709981 tgctccttcg ttcggcagaa aatgatgcag ctgtcgggat tctccgtcat cagcacatct 3710041 ttcagcaatg aaaacttatt ctcttctctt acttgaatca ccgcatgttc aatatttctt 3710101 gtggttaggc cggccgcttt gacctcgata tgctcggggt tttgcatata ttgacggctc 3710161 agcttctcga tatcctgcgg aagcgtcgct gaaaacagca tcgtcgtacg ctcagtcggc 3710221 agatgcttga taatcgcctc cacctgctca atgaagccca tattcagcat ctcatccgct 3710281 tcatcaatga ccaaataaga gagacgatcc aacggcagcg tgcctttttc gatatgatcc 3710341 agaacacgtc ccggcgtgcc gacaacaatg tggctttttt gcttaagctc agctttttgt 3710401 ttatcaaagg aggattttcc aaatacggct gtcgctttga tccgtttaaa tcgtccgatg 3710461 ttcgtgatat cttcctttac ttgcaccgca agctcacggg tcggtgttaa aataagcgcc 3710521 tgcggcttgt tttcatccca attcgccagc tcacagagag gaatcccgaa cgaagccgtt 3710581 ttcccgcttc ctgtctgtga tttgacgaca agatcctttc gttcaagggc agcggggatc 3710641 acactctgct gcaccttggt cggttctgta tatcccagtc cttccaatgc tcgtaaaatg 3710701 tcatgactga tttgatagtt tttaaaatga ctcatgtata aactcctgtc tcttgcagat 3710761 gttctcatta tactctaatt gaccaaggca tatgtgtttt gtcgaaaaat gatgtattaa 3710821 aagccagcga ttccctggcg ttttagctcc tgaacagcca atcgcgccag tgcgtcggcc 3710881 cccgcgcgat tcgggtgcag cgtatctcca tccatataaa gcccgagtgt tctttccgga 3710941 ccgatcgatg taaagtatgc cgagctgagg acatttaagt caatgagata tgttttttcc 3711001 tcttcggcca aagctaaaat agaggccctg taccatctgt ttacagacga atggatgcct 3711061 tcagaagtaa aatcggttgc ccggccctga ggcgttgata ggatgacgtc cgctcctttc 3711121 gcttttacct gacgaatcat atcacgcatc acctctttaa actccgcttc agattcttta 3711181 tgcttcggat ttgtgtcatt aatgccaagc tgcaacataa aataatctcc gggtttaata 3711241 tacttcagaa tcgcctcaag ctgtccatca tttctgaacc ctctcgcgat ctgcccgcca 3711301 gacgccatgt ttctcacttg aaaggtgtgt ttatcgatat agtgaggcag catctgcccc 3711361 cagcccgcct gcttgctgct gttgagcgga taataattgc acaccgtcga gtcgccgccg 3711421 acataaatgg ttcgattcgt taccggctga tcagacaatt tctttatttt caaggcgctg 3711481 agcgtaaaag cggtgcctgc ctttccctct gtcaccagca gattcagctg cccgtcggtg 3711541 acgggaattt ggaacgtatc ctccgcgcca tcccctgtca tattgatgac ctgaaacacg 3711601 ccctccgctg ccacactggc ccttgccgta ttgccaagcg tcaccttcac ctcataaagg 3711661 ccattcggga gatcaacatt aaacgtgtta ttgcttttcg tcccatacgc taaaaactga 3711721 accgcatcac tcttcacacc agccccggat gccgccacat ccctcatatt ctccggtgtt 3711781 tgaaaaccgt agccctttga ccggtcatac cgatcagacg ccctgacacc aatataacca 3711841 ggctccatcg aaccgcttcc aaagtcaaac tgatacacct tcggctccgc cgccttcaca 3711901 ttctcaatcc cgccaaaaca cagcatcagc atcatcacaa aaaccgctgc catccatttt 3711961 ttcatcaaga ctccccctct atgaaaacga atacattaat gcatactcgg tgattgtttc 3712021 tttatgatga ctgaattaag aaaaaaattg cgttgaggaa taaaaatgag gggagagtct 3712081 caagaagggg aaaatcagtg tgacttcttg tcacacttga tcacatccca acctccgcaa 3712141 tagaagctta tttggttttc ttcgtcatac acataataac ggagtctttc ccattgatcg 3712201 tcagtcggta caatctccaa tgcaaccgaa tcgatggatt caaggtcatc cagctttgat 3712261 gcactaatgt tttcaaaccg caattgaatg tcacaggttt gagcagatcg ttttcattca 3712321 aacacaggaa tatgaatata acgatcatct tctttcatat agaaagaaaa ctcgtttaat 3712381 gtaaatggac ctgtatcctc atcagaaaga tgctgtttca atttctcgta ttgtgtgata 3712441 ttcaaatgaa ttccctctat ttatatgatt caccgccaat catataaatg tccacagcat 3712501 cgtattcaaa ccatatgatc cgttcgcctg agtccgttag gcattggagc ttcccttctg 3712561 aaaaatagct tttatccggt tgaggatcag tgatcagaaa aacatcatca ttgatggaag 3712621 ctagcagaaa gagaaaatct gcaatatccc ggtctgcttc ctgtaatatg gattggaaat 3712681 ggaattccct tttggccagc ttcgtcacct tgtaagcatg accttcaaaa tactcggaca 3712741 ggtcttctat aaatgaacca gtcgttatta cctgtatcat gattcgatcg taggcaagcc 3712801 ctgcccaaaa acgataaaac gactctgcat cttcaagttc gcatgccata acggtttggt 3712861 caggcttaag ctcgatcatg tccaaattgc caatactgct tatagaggtt atttccataa 3712921 aatcttcccc ttatcagttg gatagcgcaa cgcaaatctc ttgtctgact tgttcataca 3712981 agagaatgtg atgatacaga tccttatcgt ttttgatcat atccggaagt atgtcaggat 3713041 acagctcaaa aaagcttttc tccaacgaac gccgctgatg ccggggtatc cttttattcg 3713101 ccagcacata atccaaactg ccagcaacaa gcataaaaaa ctcatagatt tccgcttcaa 3713161 agccgtacaa ttcatcaggg tactgctttt cttcaagctc tcgctgtctt tttctcagtt 3713221 tttgaagcac gttgatcctc tcccttccgc aataatctca tttatttcga aacagaatag 3713281 gcggatcatt atctatcgcc tccaacagct cttcaccaaa cacagtgatt gcacatttcc 3713341 acgggtctcc caaaagtccc caggagaagt cctgatgaaa aaagaaataa tagtctccat 3713401 ttggaaatac gggaacaggc cattcgccaa attcatcctt aggcattgcc tgatgaggac 3713461 taaaggtata tccgtcatgc tgccaatcta gtgcgtacat tacatcgttc tttccagtac 3713521 ctaattgaaa tgcttttaaa atagaagtct ctaaatcact tagcactccg ctcacatcat 3713581 tatgaccagc tttactgctc atcgcgcttg agatatcaaa cactcgatat ggatcaggcg 3713641 ggatgatgtg atgacatctg cttccgggct tccattttat gatcttgttc acttctgacc 3713701 agatgcggtc ttgttttgtc tgacttaaag cgcgccaatt catcataatc tcatccctac 3713761 accttattgg atatcctgct tataaacacc agaagaggcc actgcgtaaa cagcgtaact 3713821 tgtcagtttc agctgttgaa catctaggcc ttcaccgttc gaatcacagc atgttatctc 3713881 ttccatctct tgactcacat cggcagaaat caaataaaga gacgacttaa ggtctgcact 3713941 gtaacaattg aacgtcccaa ccaaaaaacc ttcttcggat atcgcgagct gatcaaatgc 3714001 ttctgagtcc ggctctttat ccgacagaat ccacacccgt ctcacgaccg tttcatcaaa 3714061 tgcggcaatg actgcatctc cgtaatacag catataaatc aagccgtttt tttctgcaag 3714121 tccataacaa tcatctacag caggcgcatc catttcttca agctttctat caatgtgtat 3714181 ttccttctgc tgaccatcta acgtaaaaca ccacacacta tggccgttgg gattctcatc 3714241 atgataaatc ccttcatcac ataaaccgac ccaaagctgt tgtttctaat ccaaaagaca 3714301 gcaggaaacc cctgaaggca agtgaaaaac acttttcacc cttccctctt ctgaaaaaac 3714361 ctttaccttc ggctcgtacg attcgtaata aacgaagaca tagccatctg cacattgttg 3714421 aaagagcaga atatcactgt atgaaatctg ctctttcact ctaaaatccc gaacatcacc 3714481 ggaaggatca tagattgtaa tggtgatacc acctttcaac ccttttccaa tgtagacacg 3714541 cccctgtgga tcagcatgga aaaaacaatc ttgggtgttc tcgttgatga ttttattcaa 3714601 ttttaatttt ttcattggtt atgctcctag gttcgaaatg aaatgataag aataaaccat 3714661 ttattagcta ttagtaacgg acaacctagt ttcattaatc gttttgggat aaatctactt 3714721 tccaattcag ccttaaatca tttagtgttt aattggtatg cataaaacga ttgatcatca 3714781 aagcgaactg tttcagcttc tatagcaatc agcattctgt tcatgtcaat aagaaagtta 3714841 gcatttgatt gatactccgg aattatagaa tttgatagat tcccgattcc ttctggatga 3714901 taactcatct caaatacttg ccaattgtat tcttccggat ctattttttc caatctcatg 3714961 tcgccaacat ctgcactata ataagcggat gccacatttt gaaatgaaat tttatgcgta 3715021 tattcacctt catcttcaaa aaccttaata tcaagtgaga gttctttttt aaacacatta 3715081 aaatctaaat gaaggacact gcacccctta tctatataat caacccattc attaatcgtt 3715141 tgatacattg tcatcccctg cctcttttta aacaataacg ccttgccacc aagcagaaaa 3715201 caaattactc cgtatattgt ttgatccaat catttaaatc atctgttgaa tgcaaataag 3715261 tttctgatga atctttcaaa tcaatcccac ttagaaggat taacatatcc cagactctat 3715321 cgtcttctac ttcggggtca tccgcataaa cataagttcc agcccaatcc gacacttctt 3715381 ctcttgttgt ttgtccattt aagacacttt tgattttatt tatgcattct attagatttg 3715441 tctcgctcaa tttgatcacc acgtattcaa gtactaaatg attttttatt agtatgcaaa 3715501 gcaccgtact gatatttaga tattgaagct ttttccgtaa aagatatgtt ccaaaaggtt 3715561 tccaatctac caataaacaa gctcacatcc gtattccgtg tgcaatatac ataaaccaaa 3715621 ctggcactta ggctcaacca aaataaaact atgattgaga atcccttcat cgaactcaat 3715681 acactccaat aagcagtcaa ggtgctcgag acattttcca aaagaacaaa ctaacgcacc 3715741 aatttcgctg ctgtattgat gaaacagcag aacgtcccgg tcatcgtaag caacatatga 3715801 ctgagatatt ttccagatca gctgtttcgc ttccgttttt tcgagggcat caacctcacg 3715861 ggtgttggct ggtattgaat ttgataaaac cagctcaagc aattgcctgc tttgcgccag 3715921 atcagcaaaa cgataagtga agcctctttc tgcacaaggg actagttttt ctttgatttc 3715981 gctcatcaat aaacgtcttt tattctcggc gagtttttcg atcaatcttt tttgcatgag 3716041 ccgcattccc tccgctgtca atttctcaac ttcttttaaa ttgattcatc attctcttgt 3716101 tttcgttgtc gttcatgttt agatttgttc taaaaaagct tgtatcgctt atcgatacaa 3716161 gctttatctt caactgctta aaactcaccc agtgggcttt tcacaaaacg ctgggaacct 3716221 ttttggcaaa tcctcttcat cccaatcaat tctatatttt tagattcttt tgtcatacaa 3716281 ataagagagg atggtaacat ctcttattta atgttccatc aataaatgcc ccatttttat 3716341 ccaatgcaga aattatttat aattaaggaa gtttagaagg attttttgta ttttcaagat 3716401 ttaattttaa agcggtcaca aaagactcta gcttttcttc attacaatta atttcgaaca 3716461 agttggagtt cgacttactt tctttataat catcaaatat aattttaatc ttaattctgt 3716521 aatttccgtt ttcttgatca atactaagaa ataagaatgg ttcaatagtc tctaaactga 3716581 tactgtcttg atttcctttt atcatagttt cgatcccaga tatcaacacc ttatattcac 3716641 tttctaataa aacagcagaa aaatcgcgaa cgacggcttt cttattttcc aacaattcaa 3716701 atacagataa aataaatgga tcatcgtcca actcttgata ccttctcggt gttaattcaa 3716761 gttctataca atcatctttt attttggcca tatttcctcc tcatttaaag tttaagtgag 3716821 ggtagttgtc atccccccct cgcttaacct tattaacgcc ttctcttaga tttatttcct 3716881 tttccgtgtg tatggaatac gtgtttagaa cccttagctc ttgaacttcc ataagctgtg 3716941 attactttac cccttttatt taaaacaact gtagcttttt ttccaacata tttcgttgcc 3717001 ccattaggtt gttttattac ttttttaggg cttcgcacag cattcagttt ggcccttaaa 3717061 ttgactccac ggcctccatt tcttcctata gattgattaa gtccatgtct tgtatgacct 3717121 gtgattttaa ctgccttctt cgtaaactta taggcgcgac tagcaccctt aaatatcttc 3717181 ccaggaccaa aattagaagc agctgcccaa gcagcacctt tccatccttt acctgattta 3717241 tatgccttat atccatcata ggctgcaaat ccggcattta ccacaagcca tacccaatgc 3717301 ccgtccggat caacattcat cactgggtta ttatttccat aagcataccc attctgatcc 3717361 aatgaatctc cgtcgctgcc cgggtctggg tcgagcgata ggaacacgcc gtttcttggc 3717421 tcgtagtagc gggccatgag atagtacagg ccggtttctt cgtcgtattg gtagcctgcg 3717481 tagcggtagc gattgtcttt tacttcgtcg cttgcttcgg tttttgttgg atttccccat 3717541 gcgtcgtatt gatacttggc aacggttttt ccagtgctgt ctgagatcgc gatgatgtcg 3717601 ccgtgagcgt tgtagtgata gaaatatttc ttaccatttt ctgtgtagga taacagctgg 3717661 ccgctgtctc cgtacgtgta tgattttgtg acgttgttgt ccgcgtctgt ttcatacaag 3717721 acgttcaagc tgtctccgtc gtagaagtag ttcgtgactt ttccgttgac ggttttttgg 3717781 attctgtttc ctttttcgtc atacttatat gttgcgaatg gcttgtcttc gccttttttg 3717841 gtaacggcgg tcaggttatc ttctgcatcc cacgtatatg tgaatttgcc gtcggatgtg 3717901 cggttgccgt ttttatcgta agagatgctt tcatcattga cttttgtcag ctggttcatg 3717961 atgttgaagg aagcgttcac cgttttgctt gagccgtctt ttatagttgt aacggttttc 3718021 cggtttccga atccatcata tgtgtattca ataacagtac cgtcttcatg ggtttctttg 3718081 acaagctgat tcagcttccc atactcatat tgcaccttgc cgcttgctga gctgtttatc 3718141 gttgtgcggt tgccgttggc atcatattca tagctttccg tcagaatgtc tccgccgttt 3718201 ttgtcaccga tatgcagcga gcttacaagg tttctttcgt catatgaaaa acttgttccg 3718261 ccgccgttgc ccgtaataaa ggtttggacg tttccatttt catcataatc aaatgaatat 3718321 gaggatgtac tgtctttcat ctcaatcatt tgatccagct tgttatacgt aaattgattc 3718381 gttccttttt ggtccccatg aatccacgag aaggttttca gcttatcgga gtcactagga 3718441 tatgtccaag tttggctgcc gccgcggtct gtcagttcgg ttaaacggtt tttgttgtca 3718501 aatgtccgtt tctttgtggt gttctgctct ttattgacga ccgacgtttc atttccattt 3718561 ttgtcatacg tgaaaatgta cttttctgta ccgttatacg actttgattt cacccggtct 3718621 gttccatcat aagaaagaga cacttcgttg ccatttggtg aaatggtttt ggtcaggttg 3718681 ctgttggcat catattcgct tgctaacaca ttgccgagag ggtcagttgt tttgacaagc 3718741 ttgcccatga catcatattc gaatttatag gtttgatctg ctcctgcccg gatggttttg 3718801 cttacctcat tgccttcctt atcatagctg tgaaggatag acgtgccgtt agagagcgtc 3718861 atgtttgtca attggtctgc ctgatcatac gtataggttg ttttttcacc ttttgcatct 3718921 gtttcagacg ttttcttacc agtttcatcg taatcagttg aagtggcgta acctagttcg 3718981 tcctcttcct tggtcacata gttgccatta ctgtcatacg tgcttttagt cagaaggctt 3719041 ccttcaatca aacggatatc atcaaaccag actgtgcctg tcgcactctt ttggaacaga 3719101 atactgatat cgactttatt gatcggcttt gttttaggga tgacgacagc tgctcggttc 3719161 cattcctgtg ttccagaagg gaatttcgca ttgtagatgc ctgtgctgcc gtcagcgtaa 3719221 gtgacattcg cctgcagaga atagtctttt tcatctgtaa atttgacgct gcttgctttc 3719281 gacattcctg tcagtgtgag ataaaccggt ttgtcatttg cgctttgccc taagacaacg 3719341 gtttgttttg ttactgatcc ggcttgggac gcactggtcc gggcagcttt taatgataca 3719401 tcatcattaa agccttcttc agaatcaacg gatgctccgc ttacattcca gttttccgtt 3719461 gctgatgtga agctgctgtt ttgaactggg ttatagcttg atgatacttc gcctttttcc 3719521 agctggactt catcaaacca tgcttttcct ttgccatctt tatctttatg atcgacttcc 3719581 atatacacaa cagctttgcc tgcattcgct ggagtcgtaa aagtgatttg ccgttttgtc 3719641 cagtcatttt ttccggctaa tgcactgtat tcattgtgaa tccattgaat tcgtttttga 3719701 tctttgtctc gcaaatcaat gttaaaatag gctcttgatt tcgcaagatc tgttttgatt 3719761 ttcccgctta atgtataggt tgtattcggc tccagctcaa ctgtttgtgt tgctgacgaa 3719821 tacccatgat ctgttccggc agacgttgat tggctcaaga cctccaatgc ctttgatccg 3719881 gaaagaactc cgcttttatc ggcgatgact gaaattttgc cgctgtcttt agaggcagtc 3719941 agattccagc cggatttttg agcttcaaag cttccatctt tcaaaatatt agttgaagct 3720001 gataaatctt tgctcgattg aatctggttt ccatatttat cataaacagc tgctgacgat 3720061 gattttccgc tctgatcggt ttcggataca gcatccagtc cgtcataagc aatatccgtg 3720121 acattgccct cggtatcctt catctttgtg acatcgttgt ttttgttgta ttcgtatgtc 3720181 tcagttccat atgcatcttt aaccgacgta acgttgccat ctttgtcata ttgatagctt 3720241 tccgttgctt ttccggtgcc gacgtcattt ggatctacat cttctacaac attgttgcct 3720301 tcatactttg tattcgttgt aatttttaac ccttccgcat catcaatgac ctgaatcgga 3720361 tttcccgctt cattatagcc atactgtact ttccggccat ttggctgtgt catgagaagc 3720421 gtctttttat cagcatcata gctgtagaca tatgtttctt ttttagcgtt gatcgctttt 3720481 tcgagacggt gaccgctata ctgatattcg gtaaagacag gctttgcttc ggtactgtta 3720541 gctgaatatt gtttgacaag gcgcccttca ctatcgtagt catagcttgt gacagtcccg 3720601 tctgtatctg taaccttctt cagcaaatca ttctcatatg agtaggtgac tttcttattc 3720661 ttaggtcctg tgatggacgt cacatggccg ttttcatcat aggtaaatgt aagcttgcgg 3720721 cctgatgcat ctgtaatggc ggtcagttga tttttgtcat tgtaagtata gacagttgca 3720781 ttgttatggc catccactac cttttggagt ttgccgcctt ttttattgaa ataagcgttg 3720841 gtttgatcct ttgtttttaa tatgaactga tcagctgttt ctgttaattc aagatataca 3720901 ccggtcggcg gctgatacgt gccatcggct tttttcgtga atcgatgtgt cgtagcgtct 3720961 tcatcgatat acattgcccc gccatccgtt gagatgacag atgtttctgc atcagcatac 3721021 cagccttgtc caaataagtg atcagagctg tcaagactgt tgtaggttct cgataagcca 3721081 agtcccggac cgcgtccatc aattgacaaa tcttcttcat tcacaatgac attgcctgtc 3721141 gcaccattta actggccgct tgggatatca atgatagacc agtactcttc tgtacctagg 3721201 aattctgcgc cttcatggaa cgttgggtta aagggcgccg ttggaatcgt ttcaccattc 3721261 gcatcatagg cgacaagcgt gaaagaataa ttcttcttcc ctttgtaatt cccatttgca 3721321 ttgttataga caggtgatgg atcgagggct aattccccgc cttttccatc tgtatgaagc 3721381 ttatagcttc cggctttgat ttcctcagaa gtcggccaga tgtttttatt ttgggttgtc 3721441 caatgatcag catcaccaac atcaaaggac tgatattctt taccgttgta aatgttaact 3721501 ttatagccct tcgcattttg aaccttttcc catatcaaat tcacataacc cgtttgactc 3721561 gattttgtat ttgtatacaa atagccagtt acattctttg gcctagcgat atcaggaagt 3721621 gccggggtag cagccgggga tgcaatggct tcgccgtctt tgttgtatgc gataatttta 3721681 aacgagtaat ttcttttggc tccatctccc ccggcgtttt tataggttgg tccgggattg 3721741 atcggcagct ctgctccgct tccgtccttt aggtgaagag catattttcc cgccttgatt 3721801 tctgcacttg tcggccagat ctttttccct tttgtggtcc aagacgtctg atttccgaga 3721861 tcaagtgtct caaagccttt cccattgaac acctgaacct tatagccggt tgcaccggat 3721921 acagctttcc aagaaaggtc gaagtatcct gtggcattcc cattattgta gccctttgct 3721981 gacggtgctt gtgcttttcc tacattaggg ataacgggct ttgccggtgc ggacatcgct 3722041 ccttcacctt ggtcaaatat cgcactgacg ccaatccaat agtttttgct tgtagcatag 3722101 cttccgccgg aattcttata gaccggggat ggatctaatg ccaattcagc tccatccttg 3722161 ccgtccagat gcagtttata tctcttggag gcaatttctg cgctcgtagg ccagattttt 3722221 ttaccttttg tgctccacga cgtgacgttg cctgcagaaa tcgcttgata ttccttacca 3722281 ttgtaaatcc ataccttata tccttttgcg ccttcaacct ttttccagct gatatcgaaa 3722341 taaccagtgg aatcgccgtt gtgataggct ttgattgtag gtgtgtttcc ctttggaatg 3722401 gtatacgtca cttcaatata tggtttattg gcggagttcg ctgaagaaat tagttttttc 3722461 caatattcct tgccgtttcc gtttgtatga agcttaaatc catagttggc cccgccggag 3722521 ttccatgact ttacagcagc ggtcacatca taactcgccc actgtccttt atggacgtcg 3722581 gcttttccga tatttttaga tgccggtttg gtgttccatg tcacttttgc attatcataa 3722641 ttgctgttga ccgtatccag ccaaaggccg gttgcctttg ttccataata ggaatgggct 3722701 acgtatgttt ttaatgtagc tttagtgaca gtcatatttt gaattggctt taggttgtta 3722761 aatttcatga acgcatagtt tgtgcctgtt gttttgtcat aatagcccgt tttcagtaca 3722821 taggccttta aattagcatc ccatttttgt gaggaggccg aatagttcgt cgtcgggtag 3722881 gcactcatga caaacgtatc cgatgaaaca gataaagaag ttgacgggtc gatagatact 3722941 ggatatacgc gttctgggtc tttcagccag ttctcgtctg ccgtaagatg aagcaaatac 3723001 ccttcttcat tcttttccag cttatagctg actttgtctg accgttcaac ctcgccggaa 3723061 agctcatcta gttttgaatc cgtcataaaa ggcttaggca cagaaaaaac aacttttcct 3723121 ttttcatcag aaaaatcaat ggatccatcc tcttgttctt tagcctgcaa atcggttttt 3723181 aactgaaatg taaatgtgtt gtatccatta tactgatgaa ggactaaatc ttcttttatg 3723241 ttttcattga atgtgaaagt ctgaagatca atattcggaa acacatccgg atacacaatc 3723301 tcattactgt cagtcttata atctgctgag gtatctttcg gagtaagtga agttttattc 3723361 gggcctttcg cttctgctag tgaatatgta accttatggt cattatgctc aaaagtcgca 3723421 taaagcccgt tcttcatttg cttttgaaaa tctgaattca aaatagcgtt ctctgtctcg 3723481 acttgtttgc ttgtcgactc ttttaactca ggagaaatgt cttcccagtc ggcatccggt 3723541 gtttcctttg tatgaatagg atcaaggtat acttcctgtt tatagacacc gtcaccttca 3723601 taatagagtt ttgtattttc tgttctttca gaggtgatct caccctcttt gtttatatct 3723661 tttggatcaa aaggtacagc ttcctcagtt tgttctttct gaagagtttc ttctggatca 3723721 tcggcagcaa tacggtttcc attctcttct tctgtagatt ttgctagtac atcggctggc 3723781 actaatgaaa tcattaaagc caacactaaa aatgctgcaa tgaacctttt aaagtttcgc 3723841 ctctttcttt ttttcatttc ctctctcctt ttgtaataaa agtaatattt actcaataat 3723901 cttaactaga ctgaaatatc attacaatat ttttctagaa aatttatctt attttaagga 3723961 ttagcgagag tcaattgacc taaaacaaaa aaaggccgca taggcctttt tacatttttt 3724021 attgtatttg ttcaatatcc gtaccctcag ctgtcacatt cgccttcccc tgcctcctga 3724081 caagcgtcaa ggccatgccc gcaaagatca ttacgatgcc aagcgtttga tagaggtcag 3724141 ggcggaagcc tgtgaagacg gtatcgagca cgatcgcgac agcggggtcg agaaatacaa 3724201 tgattgaaat aaatttcgtt gataaaaatc gtaaactgtc aaaaaacagc aaatatacaa 3724261 tacccgtatg gatgatgccg gtagatacca ccataatcca gtttccctga gataggtccg 3724321 caaaagcgcc aaagtgaata aacggaatca ggatgataac ccctaaacct gtctgcaaga 3724381 aggtggtcgt gtaaggactg agattgtgaa tgccttttcc caataaagtg gtgaacgcat 3724441 aaaacagtgc ggcgagaact gcccatatga tccctgatcc catcagctgt gtcaatgatg 3724501 tgctgccgtt aatcccggaa atcagcgcag tcccaagaaa gcagatgata atggagctga 3724561 cggagatcac atttaatttc tctctgtaga agaagctccc cagaagaaga acaagcaccg 3724621 gcgctagatg ataaacagag atggcaattg taacggacgt ttcttcaaaa gacttaaata 3724681 agaacaccca gttgaataca agaaagaaac cgcacgccaa tgtttgcagc acgtctctct 3724741 tgctccattt ttcagtttta tactggccgg acgccagcca gcaaaagcct aaaaacagcg 3724801 tcgcgcaaag gcagcggaca aagaccaatt caaatgacgg cagattggta tgctctgaga 3724861 aaaagccgat ggagccgaaa atcaccatag agatgaccat tttgattacg gctgttgatt 3724921 tttgttttga cgatatggaa ggatcctgtt gcatcaaacg tattctacct ccaatactgc 3724981 atagcataaa ctgttttttg tgaattcaga aatctacaca tagaattcct cttttttaca 3725041 tgtagatatt ataacacttc tattctaaat aaaaaaaagc gcccaagggc gcttttttta 3725101 caaatctatc gaacaatcaa aaccgggcat gttgataatt gagacacttt atggctgacg 3725161 cttccaagca tcatttcttt caggccgctg atcccccggc tgccaactac aatcaggctg 3725221 acgcctttct cttttgcgtg atttagtatc tcatgcgccg gctcgccatt cgcgtaaatg 3725281 gtttcagctt gaacgccttt ttcggctgct ttttcttttg cattctcaag gattttcagg 3725341 ccctcttttt taacctcgtt cctgatttca tcaataaagt gttcaggcac atagacaatt 3725401 cccgtcagag aagaagtcgt gacgacggct tctctcccca catgaagaat gcttagttcc 3725461 gcttgttgct cttttgccaa atgcactgcg gcatcaagcg cttttgcact catgtctgat 3725521 ccgtcaatcg ctactaacat tttgttaaac atgctcttcc cgcctttcgg actgtgggtg 3725581 gttcatcttt ctcttttatt gtccgcctgc atttcgttat tgtcaattga agcgcatgag 3725641 ttttcaaaaa attgtcagag actctctccg tttgtggcga taacctgctg ataccagttg 3725701 aagctttttt tcttgatgcg gttaaatgtt ccatttcctt cattgtcccg gtctacataa 3725761 atgaagccgt agcgcttttt catttccgca gtagatgcgc tgacaaggtc aattggcccc 3725821 catgatgtgt atccgattaa ttcaacgccg tccgcaatgg cttcgcgcgc ttcaattaaa 3725881 tgatcacgca gatagttgat tctgtaatcg tcctgaatcg tgccgtcctc ttcaaccttg 3725941 tctacagcgc caaggccgtt ttcaacgatg aacagcggct tctggtaacg gtcgtataag 3726001 gtgttgagcg tgatgcgcaa gcctttcgga tcaatctgcc agccccattc tgatgatttg 3726061 aggtaagggt ttttgactcc gcccagcagg ttgccccctg attttgcaag ctcttccgga 3726121 tctgtgctcg ccgccatcga catgtagtag ctaaatccaa tataatccac cgtatgttct 3726181 ttcaagagct cttcatcgcc ttcagccatt tcaatttcaa tattgttttc tgccagatag 3726241 cgtttcatat atcccgggta tgcgcctctt gcctgaacat ctgagaagaa aagtgttttg 3726301 cgctcattct ccattgccgc gaagacatcc tccggcttag aagtcatcgg ataggttgtc 3726361 gttgccgcta tcatacagcc gattttcgaa tcaggaatga tgtcgtgacc cgctttgaca 3726421 gcaagagcac tggccacaaa ttggtggtgt gccgcctggt acatcgcgtt taatttgttt 3726481 tctccttctt caaaaacaag accgcctccg gtaaatggcg catggagcac tacgttaatt 3726541 tcattaaacg tcatccaata cttcactttg tgttgatagc gtttgaaaac cgttttggca 3726601 tagcgttcat aaaactctat gactttgcga ttcttccagc cgccataatt tttcactaaa 3726661 ccgagcggca tctcataatg agagatggtt acgacaggct caatatgatg ctttaacagc 3726721 tcatcaaaca gatcatcata aaatctgagg ccttcttcat tgggctcctc ttcatcgcca 3726781 ttcggaaaaa ttctcgtcca cgcaatcgat gtgcggaacg ccttaaatcc catttctgca 3726841 aataaggcga tatcctcttt ataacgatga taaaagtcaa tcccgttgtg atacagattc 3726901 aaggaagtca ttgattcatc aaatggagac atgatcccgt tcggcgatac gtcagctgtc 3726961 gaaagcccct taccaccctc gttataagca ccctccactt ggttggcagc aactgcgccg 3727021 ccccataaaa atccttctgg aaatcgtttt tcatttgaac tcatattgat caccccatta 3727081 gttttttcaa gataaagcaa gcagcgcttc ttttggctgc actttaccga tctctttcac 3727141 cggcgaaaac gaatattggt ctgtgttggt cacaatcacc ggggtaatga cgtcatatcc 3727201 cgcggctttg atttgctcca gatcaaagga cacgagcgga tctcccggtg cgaccttgtc 3727261 gccttctttg atgtgagccg tgaaccattg tccctccagc tttaccgtgt ccaatccaat 3727321 gtgtatgagt atttcagctc cctgatcact cgtaatgcca attgcgtgtt ttgttttaaa 3727381 aatggtggta acgcttccac gaacaggcga aacaacttct ccttcttcag gctcaatggc 3727441 aaatcctttt cccatgaccc cagcagaaaa cactccgtct ttgacttcac ttaaggcttt 3727501 cacttctccc ttaatcgggc tgtgaatgat ctctctgctg ccttcatgca ctgccggctg 3727561 ctggctgccg tcagaaggca catcctcgaa tccaagcaaa tacgcagctg ctgttcccgc 3727621 cgcaaacgca atcacaaggc cgatcatcgc gtaaataaac gttgggccga taaagacagg 3727681 gatgctcggc agacctgcat tccccccgac gatataggaa gcaacacccg tcatgccgta 3727741 aaacgcgcca ccggctgcac cgccaatcaa agcggccgca aacggctttt tcaatcgcat 3727801 attcacgccg tacatcgcag gttctgtgat ccccatcagc gccgtgatgc ttgtggtaag 3727861 cgcgagtgat ttaaattttt tgtttctaga gcgaaggaag acggcaaatg atgctcccgc 3727921 ctgccccata ttcgccaaaa acatagccgg cagtaaataa tcgtggccgt tttgagcgat 3727981 gttgttgatc atgatcggca caaaggcata gtgcatgccc gtcataatga ttaaagagaa 3728041 tgtacccgcc agcaaaatca ttgccacaag ccctgcatga tcaaacaaat aattgacccc 3728101 agaagacaag tattctccta aaatagcgcc aagcggaccg actgtaatca atgtcagcgg 3728161 cacgacaatc aatagcgtga atgtcggaac cacaatcaat ttgagagatg cgtgtgtaaa 3728221 acggtcaatc catttttcca cgtatgaagc aatccaaatc gacagcaaaa tcgggatgac 3728281 cgttgacgaa taagtggcag cggttacagg aagcccgata aaggaaatcg gtttccccgc 3728341 accgagcagg gctgtcaaat ccggatgcag gatcgccgcc gcaatggcag ccgctacgta 3728401 cggattgctt ccgaattttc tcgccgcact catcgctagc aggagcggca ggaagtagaa 3728461 cgcaccgtca ccgacagccg tcaaaatgac atgaacctgg ctcttctccg ccatccagcc 3728521 aaacgtgact gccagcgcca caagtccttt gatcatcccc gctcccgcaa tcgcaggcag 3728581 aataggggta aacaccccag aaatcacatc aaagaccgca ctcagcacat tctttttctg 3728641 agaggatgaa ccagcgctct tttcatcact gagattgctg tgccgcacaa tcgcctgata 3728701 caccttcggc acatcgtttc cgataatgat ttgaaactgc tcgccgctga tattggtgcc 3728761 catcactcca ggcagctgct ccagctgact gcgatccgcc ttcgcgttgt catgaagatt 3728821 aaaacgcagc ctcgtcatgc agtggatcac gcgctgaacg ttttcttcac cgcctacgag 3728881 ttgtaatatg tccttcgata atttatcata atccatgtgt atacctcctt tttatggggg 3728941 gactgctgga tgaaaggtgg ccgcctttca ccagcttttt ttgtatcaaa tgctgcatca 3729001 cctcctaaaa gagaataaaa aaacctaaat gacacagatt gcgagagtct cctcctgcac 3729061 ctgcaccatt taggttttgc ctgctttcgc agtaacaatc ctgacgggtc gttttatttg 3729121 tttgtaggta tactttagca ctagattcgt gagatgtcaa cgctttcatt tttggtgttg 3729181 actatcgttt ctagaacaaa agtaatcata aagatttgaa cttagtatta acttcaataa 3729241 aaaattattg taattaaaaa ccttgaaagg cattttttcc aatcaaggtt atgaatcgtt 3729301 accgtttaaa tttttttaaa gacttcttta tctgtactat tacattcttt agccaatcta 3729361 ttggttctaa attaaacgca ggaagataca cgccatctgc gcaagattga atgtaatcgt 3729421 ttttcttatt gtctgaatgc tcactttcaa taaaatccgt taaaaagaca atagcatcct 3729481 ccaaatattc cttactttcc tctattaata actcttgtat agcgtcatca ggagtttcaa 3729541 tatcttgatg gaatgttcca gctaaaaact gaaaaacagg gtccttctgt ttattgatca 3729601 ataacatgtc atcttgctcc tttaagggag aggtaacggg ataatgttaa aatcattcat 3729661 catctaataa atcaagataa tactgatcat tctcttctat ttttcttaag aactcggtaa 3729721 gagaagttgc aatttgaata tcataatagt aaatcggatt tttattatta tcatttaatt 3729781 caattgacat taatgccgat tcactacctt caaaaaatat taatttatca ttctcaaact 3729841 catcatatat ttctatgtca ggataaaatt caaagtcatt tatcctcaat cgaaagtctc 3729901 ttacagaata tggatccaaa atgcgattag tattaaactc tgatccttta ataaacccat 3729961 agccaacttc taaataaaaa ttcactaatt cactaggtaa ttttaagttt aaattttttt 3730021 caacctcttc aatctcactt tgattcactg gataaaaatc attttctttg tttgatttta 3730081 taaaattata actcattttt ttttgcctcc tttaaataat tcatttgctg gtgagcctgt 3730141 accatgaatc ccagcttgat gctcgttagg aaattttgct ggatgcatat tccaccattc 3730201 atgttctccg ccaaaagtat tttcaattat atggtgagca tcatacttat cccctttttt 3730261 tctaataatt ttacctgttt tttcagatac aacattttcc ttataaacag gccatttttg 3730321 tccagtgttt tcttcccatt cttttataac tttatttttt actttatcaa atttagtcct 3730381 gtgttttgca gtctctattg gtgacatttt tttatattct ttatttctta atgcttcctt 3730441 taatttatct atttgatttt taggtaattc tctacctgtg cgttgttcta tatctctagc 3730501 atactttttt attaaatcag aattaatttt attagcagat ccacttacat cattcgcaat 3730561 tttcccttta tccttagcaa cgtttttaac ttccgaagcc ttcttagcct ttttcccatt 3730621 attaataagt ttattaatat ctattaactt ttctaactta gctattttgg caaatggtac 3730681 tgagtttatg gaggcaacaa cacggtcttt ccctgtgact ttttcgcctg ataccggatc 3730741 tctgcccgtg gctgctttaa atagatcata cacgccggta agttctacag ccgtctctaa 3730801 aattttcaca tatccattct catccacttt aatgtccgaa agcgagacga caggttcaag 3730861 cttcatgtca ttaccagata tgtatacatt gtaaagtgta tcattataaa cgacttgctt 3730921 aacctctgca tttgagaaat cagtttttat atgttctcta tgttcactcg tattatacac 3730981 tttaccattg ataacgatga tatttttact taccttttta gaatcacccg ttttgacaac 3731041 tgaatccact ttagactttt cattctcggc taatttcttc agcatcatct ccatcggtga 3731101 atcatccgcc tgcttcattt gcgggttaat cgcgccgaag atttggttga tgttttcttc 3731161 ttcctgtgat ttcaggatgg agccgctttt gtagcctgtg atttcaattt tcgggccggt 3731221 gtacatggtt tcgagctgat caatgtattt tttcatcgtt tgaaaatctg attttgcggc 3731281 ttctagtgct tgggtttgct ggccgtcaaa ttgaaagagc ttattcaggg tgtctgaaat 3731341 cagccgctca gcctgttctg tttccatccg aaaaaaggaa tcattgactg tcggcaggct 3731401 gacgatgtga tctatggctg atgtctggcg attgactgcg tcagtgagct gctctgtcac 3731461 ttctcgtgca tgcttgaccc catgtctcgc atcgtgtgag agaaaagcct ctgcgatcat 3731521 gccgtgggag ttagattcta cagaggaaat cgcatgctgt gtttgtttca gcactttttt 3731581 gtattcgtcg ataaatatgc caaagaaaag gagaaaaggc ttgtggcact cctcgtaaaa 3731641 ggtccggatg gcatctccgc cttttccttt cagcgcatcc ttcatgcctg ccagatgctc 3731701 aacgcttttt tccagcttct ccagctgttg tttttgcttg tccagtttct caatcgtatg 3731761 ctgaatgccc tcgtgaagag cgtggacatc taatgttttc aatcccttgt cctcccgcgc 3731821 tttatttcat ggaagatgat atgttttcgt ccgtttcctt catggcgttt accgcgcttt 3731881 ccgtttgtgc gatatgcttg gccagaacag acgcatatgc ttcagtgagc tctttgatgt 3731941 ccttatttaa ttgctcgatg gacttcacaa cattcaaatg gtttctgcct gagagatgac 3732001 cgggcaatga ggacttgagt tcagctgaat tcttgagctg agaaagccct tgcttcactg 3732061 tgtcatacac cattttaatt tcctgtgcca tttgtgctca cctcactttt tatgtttttc 3732121 cttctctatt tcatgctcta tcctcgtgat ttggcgtctt atagaataca catcgccctc 3732181 taatgagtgg atttttcctt ctatgctttc gatgattccg ctgacttgat cgcttttgat 3732241 ttgctgatat gctttgttca ttccttcacg aatatcttca aaccgctcag catgtgttcc 3732301 tctccatgcc tcccggttaa gatgaggccg gtgaatgaga tgctgggcct cagagaaatc 3732361 gtgtttgatt tgcctaattt cgtgcagcac tcgttttaat tgatggatct gttcctgctt 3732421 ttcatgtaag tcggctttta ccgaatgtaa caacatttca ctatgcatgc cgcaacacct 3732481 cgtgtttcta tcaaactgtg taaattcttt acaatacaga ctattttcat attacatgat 3732541 gggtcatatt ggataaatag gtaaaaagga ttgtcttgag aggtatagaa ctggttctaa 3732601 attgctaaaa atacgatctc atcaccctat gaaaggagaa aacaatcata gtagggactt 3732661 tttatttaag cctttaatct ctcctccagt tctaattttt cctcccactt aactgtttct 3732721 tatagtcaat aaagctcata aaaaaacacc ttccctcgaa ggcgcttctc catcttattt 3732781 agatccccat acagcctcac cgctggtatt cagcacacta aacgtcatga cgttcttctc 3732841 tctcaccgaa tcccactggc gtaaaaatac cccgttatac ttcttgcctg ctaacgtgat 3732901 gtcggcggtg ttttttccgg ttttcctcca tgttccggtc atttccccgg aaatggtgtg 3732961 gtttttgttg agctggatgt tgatggtttg tttgatgtcg gctgagatgt cttttccgtg 3733021 ctggataagt ttgtatgttc ctgtgatgtc tttttgtttt acttctttca atgtttcgcc 3733081 cgcataacga tatggtgctg ctaccggcca gccgtctttg ttcatgaaca attggtggac 3733141 tctgacttcg tgttcttcac ccctgcccgg gaagcgggtg tggaagatta aataggaacg 3733201 cccggttttt tcatcatagt atgcggagtt gtggcctggt gagacgtacc cggtgccttt 3733261 ttcattttct gtttcaaaag tgtagctgcc catgagtttg acgccgtatg gttcgatgga 3733321 acggtcgtcg aagaatgtgc ctcccttgcc gcggacgtcg agcattggat tgccttctgc 3733381 atcatagtaa gggccgtccg gtttcttgga gcgggccaca cggatgttgt agccgcctgt 3733441 tgcatcgaga ccgccatatg ataggtataa gtagtagtat tgggtgtctg gattgtagag 3733501 aacatacggg ccttcgattc tgctgtggtt gccgccgagc agttttttcc catatccctg 3733561 tccaggaagc gggaagcccg ttttcggatt catttcaagt atgaaaatgc cgcctgagta 3733621 tgatccgtac accatccaca gcttgccgtc tttatcaaag aaggtatgcg ggtcgacgac 3733681 attcggatgt ttggttgcat catacggtgt tccatcgctg cttgtgcctt ccattcctga 3733741 tttcaaaaag atgcctttgt ttttgtatgg gccttcgatg ttgtcagcaa cggcaacacc 3733801 catggcggat cttggcgaat cgccgcggca ggcgttgtag tacatgtagt atttgccgtc 3733861 cgccagctgc gtgacgtcag ccgcccaaag agtatcggat tgcgcccatt cgaaggtttc 3733921 ttttaattct tcatagacat tcgggataag tgggttgtca ttgcttacgc tggtggtcag 3733981 ctgctgccat tgcatgaggt cattcgattt agctgaagcg agatgagatc caaaaacata 3734041 aaaagtgccg tttgtttcaa tgatggaagg gtcatggacg ctgacttctt taaatatagg 3734101 tttttgtgca tagacggagt ttgggagggt gaaggccatg ataagagctg caagaaaaca 3734161 tacacggaac aatcggttga acatctaaac aattcgcctc tcttttttat taaattttaa 3734221 acgcttacat ttctctatga agataccccg gcctattaaa acagccgaat gttttcatat 3734281 tcatccagat aggtgatttc tcacttcact tacatagtca gactgatgtc tgtctgtttt 3734341 gcgcagaact tgttgcttgc atatcctctc cttcatagtt caactctttt gctgtttctc 3734401 cttcttgcat cacgtctgtt tttctttcgc gtacatgtaa taactgcttt gtcaggtttt 3734461 gcatcaactg tgatacagcc atttcgttgt cggcgttttt taagatgatg cctgattgcc 3734521 cgtcaacacc agagtcattc ggctggctct ttataaaacg ccttgcgaaa aatacgactt 3734581 agtaaacgca tattgagagt tagacagcgg cgcttgcctc cttgtctgga tatcgtgtgc 3734641 aatcgctgaa aaaacctgtt ctgctttctg cgtcacgcta ttacaatagc aatctaactt 3734701 gttaaagact ataaaaaaac cttttgactt ctgctgctga accaattaat ataatactca 3734761 gttaatagtt atcagaattt ttaggaattg agtgattcat atgacactgc ataaagagcg 3734821 tcggatcggc cggctgtctg ttctcctgct gctgaatgag gcggaagaaa gtacgcaggt 3734881 tgaggagctg gagcgagacg gatggaaggt ctgtcttggc aaggtaggat caatggacgc 3734941 acataaagta gtagccgcaa ttgaaaccgc ttccaaaaag agcggtgtca ttcaatctga 3735001 gggttatcgg gagtcacatg cgctttatca tgcgacgatg gaggctttgc atggcgtgac 3735061 cagaggtgaa atgctgctgg gatcgctgct tcggacggtg ggattgaggt ttgccgtttt 3735121 gaggggaaat ccttatgaaa gtgaagcgga aggcgattgg atcgctgtct cgctttacgg 3735181 aacaatcggg gcgccgatta aaggtcttga gcatgaaaca ttcggcgttg gaattaatca 3735241 catatgaaac agcccataga tcttagacga tagggggcta tgcgtgaaaa cagaagttca 3735301 cagcatagct cctttttgta tgggcgcttt accaaagtaa agaaaaagga gttgggctta 3735361 tggtgacttt agacggttct tcattgacaa cagccgacgt cgctcgtgtg ctgtttgatt 3735421 ttgaggaggc agcggcttct gaggaaagta tggagcgcgt gaaaaaaagc agagcagcag 3735481 tggaacggat tgtacgcgac gaaaagacaa tctacggcat caacaccgga tttggcaaat 3735541 tcagcgatgt cctgattcag aaagaagact cggcggcgct gcagctgaat ttaatccttt 3735601 ctcatgcctg cggagtcggc gacccttttc ctgagtgtgt ttccagggca atgctgcttt 3735661 tgcgcgccaa tgcgctgtta aaaggctttt ccggtgtacg cgctgagctg atcgagcagt 3735721 tgcttgcttt tttaaataaa cgcgtccatc ctgtcatccc tcagcaagga tcacttggcg 3735781 caagcggaga tctggcgccg ctttcccact tggcgcttgc gctgatcgga caaggagaag 3735841 tcttttttga gggggaaaga atgccggcaa tgacaggctt gaaaaaagca ggtattcaac 3735901 cggtaacgct gacatccaag gaagggcttg ccttgattaa cgggactcag gccatgactg 3735961 caatgggggt ggtcgcctac atcgaagctg agaaactagc ctatcaaaca gaacgaattg 3736021 ccagcttaac gattgagggg ttgcagggaa ttatcgatgc atttgacgag gatattcact 3736081 tagcccgcgg ctatcaggag cagatcgatg tcgcagaacg aattcgcttt tatctatctg 3736141 acagcggcct gacaacctcc cagggagaac tgcgggtaca ggatgcctat tcattgcgct 3736201 gtattccgca agtacacggt gcgacttggc agacactagg atatgtcaaa gaaaaattag 3736261 agattgaaat gaacgcagct acagacaatc cactcatttt caatgacggt gacaaagtga 3736321 tttccggcgg aaactttcac ggacagccaa tcgcctttgc catggatttt ctgaaaatcg 3736381 caatatcaga gcttgcgaat atcgcagagc gtaggatcga acgacttgtg aatccgcagc 3736441 tgaatgacct gccgccgttc ctgagccctc atcccggtct gcaatccggt gcaatgatca 3736501 tgcagtacgc cgcggcctca ctcgtttctg aaaataaaac actggcccat cctgcaagtg 3736561 tggattccat tccgtcatcc gccaaccaag aggaccatgt cagcatggga accatcgccg 3736621 ctcggcatgc ttatcaggtg atcgcaaata caaggagagt cattgcgatc gaagccattt 3736681 gcgcattgca ggctgttgaa tacagaggca tagaacatgc agcgtcctat acgaaacagc 3736741 tttttcaaga aatgagaaaa gtcgtgccgt ccattcagca ggaccgtgtt ttttcctatg 3736801 acattgaacg cttgactgac tggctgaaga aagaatcttt aatacctgat catcagaata 3736861 aagaactaag ggggatgaac atatgactga tgtaaaaaaa tcaatccgtg ccaacagagg 3736921 aacagagctt gaatgcttag gatgggagca agaggcagtg cttcggatgc ttcgaaacaa 3736981 ccttgatcca gaagtcgccg agaagccgga ggacctcatc gtatatggcg ggattggcaa 3737041 agccgcacgg gattgggacg cttttcacgc cattgagcat tccttgaaaa cattaaaaaa 3737101 tgatgaaaca ttgctcgtgc aatccggaaa gcccgttggc atgttccgta cacacccgca 3737161 ggcccctcgc gtgctcctag caaattctgt tcttgttccg aagtgggcag actgggagca 3737221 tttccacgaa cttgagaaaa aagggttaat gatgtacgga cagatgacgg ctggcagctg 3737281 gatttacatt ggctcacaag gcatattgca aggaacctat gaaaccttcg ctgagctggc 3737341 gcgacagcac ttcgggggca gcttaaaagg aacgttgacg ctgacagcgg gtctcggcgg 3737401 aatgggaggc gcccagccgc tgtcagtcac gatgaatgaa ggcgtcgtga ttgccgtcga 3737461 ggttgacgag aaacgcatcg acaagcggat cgaaacaaaa tactgcgatc gaaaaacagc 3737521 atcgattgag gaagccttag cttgggctga agaggcaaag ctggcaggaa aacctttgtc 3737581 cattgcactt ctcggaaacg cagctgaggt gcatcacaca cttttgaacc gaggcgtcaa 3737641 aattgatatt gtgacagatc agacatctgc ccatgaccct ttaatcggtt atgttcccga 3737701 gggctattcc cttgatgaag ctgaccgttt gcgtcaagac actccagagc tttacgtgcg 3737761 ccttgcgaag caaagcatga aaaaacatgt cgaagccatg ctggcctttc agcaaaaggg 3737821 ctctattgta tttgactacg gcaacaatat ccggcaagtc gcaaaggatg aagggctgga 3737881 gaatgccttc gattttccgg ggtttgtccc tgcctacatc cgccccttat tctgtgaagg 3737941 aaaagggccg ttccgctggg cggcgctttc cggagatccg gcagatattt accgtacgga 3738001 tgcgttatta aaagagctgt tcccgacaaa taaagccctt caccgctgga ttgatatggc 3738061 acaggaaaaa gtcaccttcc aaggcttgcc gtcccgtatc tgctggcttg gatatggaga 3738121 acgaaaaaag atgggcctcg ccattaacga gctggttaga accggggagc taaaagcgcc 3738181 tgtcgttatt gggagagatc atttggactg cgggtctgtc gcctctccaa accgggaaac 3738241 agaagcgatg aaggatggaa gtgacgctgt cggtgattgg gctgtgctaa atgcgcttgt 3738301 caacacggcg gcgggtgcaa gctgggtttc cttccaccat ggcggcggcg tcggaatggg 3738361 ctattccctt catgccggca tggttgcagt ggccgatgga agtgagctgg ctgacgagcg 3738421 gctcgcgcgg gtcttaacga gcgacccagg aatgggcatt atccgtcatg cggatgcggg 3738481 ttatgaacgt gccgttgaag tagcgaagga acaggacatt atcgtgccga tgcaaaaata 3738541 aaggagtgat gacatgccaa agcaaattga tacgattctc atcaacatcg gtcagctttt 3738601 gacgatggaa agcagcggtc cgcgggcagg caaaagcatg caggatcttc atgtgatcga 3738661 agacgctgtt gtcggcatcc atgaacagaa aattgtgttc gccggacaaa aaggggctga 3738721 agccggttac gaggcagacg aaatcattga ctgttcggga cgccttgtaa cgcctggcct 3738781 cgttgatccg cacacccatc ttgtatttgg cggatctcgt gaaaaggaga tgaaccttaa 3738841 gcttcagggc atttcatatt tggatattct ggcgcagggc ggcgggattc tgtctacagt 3738901 caaggatacc agggcggctt cagaagaaga gctgctgcaa aaagcccatt ttcatctgca 3738961 aagaatgctg tcctacggca caaccacagc agaagtgaaa agcggctacg gcttggaaaa 3739021 agagacagag ctcaaacagt tgcgtgtcgc aaagaaactg catgaaagcc agcctgttga 3739081 ccttgtttcc acatttatgg gagcccatgc gattcctccc gaatatcaaa acgatccaga 3739141 tgattttctg gatcaaatgc tttccctttt gccggaaatc aaagagcagg agctcgccag 3739201 ctttgctgat atttttacag aaacaggcgt ttttacagtc agccaatccc gccgttattt 3739261 acaaaaagca gctgaggcag gcttcggatt aaaaatacac gcagatgaaa tcgatccgct 3739321 tggaggtgct gaattagcag gtaagctaaa ggccgtctca gccgaccatt tggtaggtac 3739381 atcggacgaa ggcataaaga aattggctga ggcaggaacg atcgccgtcc tcttgccggg 3739441 cacgacattt tatcttggca aaagcacata cgccagggca agagctatga ttgatgaagg 3739501 tgtatgtgtc agcttggcaa cggattttaa tcctggcagc tcgccgactg aaaatatcca 3739561 gctgattatg tccattgccg cgcttcatct gaaaatgact gcagaagaaa tatggcacgc 3739621 ggtcacagtc aatgccgcat atgccatagg aaaaggagaa gaagccggtc agctcaaagc 3739681 tggccgctca gctgatcttg tcatttggca agccccgaac tatatgtata ttccgtatca 3739741 ctacggggtc aatcatgtac atcaagtcat gaaaaatgga acaattgttg tcaacaggga 3739801 gggagccatt cttggataag tacccttttc tcagagaggc cggatcttcg tttaaagacc 3739861 gggatgtcac aaaaatgagc gacctgatcg caacatggga cggccaggac attaagggac 3739921 cggcgttgat aggtgtcccc ctatcaaaat cctccatcag tcattcaggc gcttcctttg 3739981 cacccggaac aatacgccag gctctgaaac attcatcagc ctattctgct gagcttggag 3740041 agcacgtcgt atcagagctt ctatatgacc tgggggatat cgatattcat gtcactgata 3740101 tcgtaaagtc acatcatcac attttccaaa ccatgcacgc tctgctttcg gatcatccgg 3740161 attgggtgcc gctcatactt gggggagata actctatcag ctactccaca ataaaagcga 3740221 tagcacaaac aaaaggaacg acagcggtga ttcaatttga tgcccatcac gatgttcgca 3740281 atacggagga cggggggccg acaaacggca cccccttccg ccgccttttg gatgaagaga 3740341 tcattgaagg tcaacatttg atccagctgg gtatcagaga attcagcaac agccaggcct 3740401 atgaagcata tgcaaaaaaa cataacgtga acattcacac gatggacatg atccgggaaa 3740461 aaggactaat cccaacgata aaagagattt tgcctgttgt tcaagataaa acagatttca 3740521 tttttatatc tgttgacatg gatgtcttag accagtccca tgcacccggc tgtccagcga 3740581 ttggcccggg cggcctctat acagacgaat tgcttgaagc agtcaagtac atcgcacaac 3740641 agcccaatgt tgccgggatt gaaattgttg aagtcgaccc taccctcgat tttcgagata 3740701 tgacaagcag agctgcagct catgttctgt tacacgcatt aaaaggaatg aaactctccc 3740761 cattcaagtg atcttctggc aggttgtatt ttgggtataa gaaactcatc tgcctaagga 3740821 atggcagcta aaaggagggc gagacagtga atcttcagga gaacagcagc caacagctaa 3740881 aacgcacaat gaaaagcagg cacctattta tgatctcatt gggaggcgtc ataggcacag 3740941 gacttttcct cagtacgggc tatacgctac atcaagccgg acccggcggt acgatactcg 3741001 cttatgtaat cggcgggttg atgatgtacc tcgtcatgca atgtctcggc gaattgtcgg 3741061 ttgccatgcc ggtgaccggc tcttttcaaa aatatgctac aacatttatc ggtccatcta 3741121 ccggttttat ggtcggcatc atgtactgga tcaattgggt ggtgacggta ggctctgagt 3741181 ttaccgcatc cggtattctc atgcagcgct ggttccctga cagcagtgta tggatgtgga 3741241 gtgcgatttt tgcagccctt ctttttatat gcaacgcatt ttcagttaag ttatttgcgg 3741301 aaactgaatt ttggttttcc agcgtaaaga ttgtcaccat tattttattt atcattttag 3741361 gaggagccgc catgtttggc ctgatctctt taaacggaac ggcggatgct cctatgttgt 3741421 caaacttcac agatcatggc gggttgtttc caaatggctt tctcgccgtt tttatcgcga 3741481 tgatatctgt gagcttcgcc ttttccggta cagagttaat cggcgttaca gcaggagaat 3741541 cagcaaatcc tcaaaaggat ataccgcgat ccatccgtaa tgtcgcatgg agaaccgtga 3741601 tttttttcat tggcgctgtc ttcatattat ccgggttgat ttcatggaag gacgcaggcg 3741661 tgattgaaag cccgtttgtc gccgtatttg cggagatcgg aattccttac gctgctgata 3741721 ttatgaattt cgtaatatta acagccttgc tgtctgtcgc caactcaggc ttatatgctt 3741781 cgacccgtat gatgtggtct ttagcaaatg aaaacatgat cagctcccgt tttaagaaag 3741841 tgacatctaa aggcattcct ttaaatgcct taatgatcag tatggctgta tcttgtttat 3741901 ctctcgtttc cagtatcgtg gcccctggaa ctgtctatgt ggtgatggtc gcaattgctg 3741961 gatttgcagg agtcgtggtc tggatgagca ttgccttgtc ccaactcttg tttcgaaaga 3742021 gatttttgaa aaaagggggg gatgtaaaag atctgacatt tcgcacgccg ctttatcctc 3742081 ttatgcctat agccgctctc ttattatgtt ctgcttcttg tatcggtctt gcttttgatc 3742141 ccaatcaaag aatcgcactt ttctgcggag ttccttgtat catcctttgc tatctcatct 3742201 accatttcaa aagaaatgtt acaaaagcga aaaaaatcag ccaagaggaa tatccagccg 3742261 atcacatcct ataattaaaa aagcacaccc cgctcagcat gggatgtgct ttatttttta 3742321 ttctgtaatt aacgtatgaa tcagcttcgg cgccttcgct tccgcggcga tgcggatgtt 3742381 gtcatagact tttgcgatga cttcatcgac gttttctcgg ttagcgtaaa gcgttacgag 3742441 cggttcccct ttttctactt tgtcgccgac ctttttgcgg agcatgatgc cgacggctaa 3742501 atcgatttcg tcttcttttg tggcgcggcc ggcacctaac agcatcgccg cgacgccgat 3742561 ttcgtccgcg acgatttcag agacgacacc cgcttctttg gcaggcacat caatttgata 3742621 tgcggcttgc ggaagcttag acggatcgtc aacaattgag ctgtcgccgc cttggttttt 3742681 caggaaatcc ttgaatttct caagtgcttt gccgtttttc atgacttctt ccagcttcgc 3742741 tctcgcttcg tccaatgtat cggctttttt cgcaagcaca accatctggc tgccgagcgt 3742801 taagacaagc tcatgaagat cctcaggccc ctcgcctttg agcgtgtcga tcgcttcttt 3742861 gacttcaagc gcatttccga tcgcaaagcc gagtggctgg gacatgtctg aaatgacagc 3742921 cattgtttga cggccgacgt tatttccgat gcgtaccatc gctttggcaa gttcagctgc 3742981 gtcttcttct gttttcatga aggcgcccgc tcccgttttt acgtcaagca cgatggcgtc 3743041 cgccccggca gcgatttttt tgctcataat cgagcttgca atgagcggaa tggaattgac 3743101 cgttcccgtt acatcacgaa gcgcgtacag ttttttatca gccggcgtta aattgccgct 3743161 ttggccgatg accgcaacct tgtcgcggtt cacaagttta ataaattcat ccttcgtcag 3743221 ttccacgtgg aagcccatga ttgcctctaa cttatcaatc gtgccgcccg tatggccgag 3743281 gccgcggccg gacatcttag caaccggcac atcaagagcc gcaacaagcg gagcgagaac 3743341 gagcgttgtc gtgtcgccga cgccgccggt agagtgttta tccactttaa ttccttcaat 3743401 ggcagaaaga tcaatcgttt caccggagtt caccatagcc atcgtcaagt ccgcgcgttc 3743461 acggtcactc atatcctgga agaaaatcgc catagcaagc gcgcttgcct gataatcagg 3743521 aatgcttcca tctgtatagc cgttcacaaa aaattgaatt tcttcagtgg tgagttcttt 3743581 tccgttttgt tttttgatga tgatatctac cattctcatg tttggtcacc gatccttttc 3743641 gattaagttc agtaaatcaa gcccacaatt gctgctgata aaaagctgac aagcgtagca 3743701 ccgtataata atttcaagcc gaaacgagcg acgacatttc cttgcttttc attcagtcct 3743761 tttacggcac cggcaatgat tccgattgag gagaagttcg caaatgacac aaggaatacc 3743821 gatacgatcg ctgttgtacg gccgctgaaa tggaaaccgt tttgcgtaag cgacgtcatg 3743881 gcgacaaatt cattcgatac catttttgtt gccataatgc ttcccgcatt aacagcttca 3743941 ttccatggga taccgacaag aaaagcgaat ggagcaaaca catatccaag aatgccttgg 3744001 aacgaaatac cgaatactgc attaaaaatg ccattgatca atgcaataat cgcgacaaat 3744061 ccaatcagca tcgcagcgac gacaaccgct actttgaaac cgtcaagaat gtattctccg 3744121 agcacttcga agaaggattg tttttcttct tcctcaacac gaagcatatc ctcttctttt 3744181 gcaacctcgt acggattgat aatagaagcg ataatgaaac cgccaaataa gttcaaaaca 3744241 agcgctgtta caacatattc cggtttcagc attgtcatat acgcaccgac aatcgacatt 3744301 gatacagttg acatcgcaga tgcgcaaagc gtgtacaagc gctgctgatt taaaagaccg 3744361 agttctttct tcaaggagat aaatacttct gactgcccta aaatcgcaga agccactgcg 3744421 ttatacgatt ccaatcttcc cataccgttt accttgctga gggcaaggcc gatatatcta 3744481 atgataaacg ggaggacttt ccacttttgc agaatcccga tcagagcgga aataaacacg 3744541 attggcaaga gaacattcat aaagaatgtc gtttggtccg cattcaccaa gccgccaaac 3744601 acaaagttaa ttccctctgc cgcgtattca agcaggtaac cgaatccttt tgcaaatcct 3744661 cccacgagga aattccctat tccggtattg aggagaatgt agccaagaat aaattgcaaa 3744721 atgagcataa caacaattgg gcggatctta attctttttt tgccgctgct cgcgatccac 3744781 gcgaggccta aaaacacgat taaaccgata atcccaatca aatacttcat atgtgtttct 3744841 cctttatttg tattcgctta caattactgt ttcctcagaa aacggaaagc agtctgcctt 3744901 ccgtcagctc ttaatagttg tctccgcctg atgcattttc tccttttacg atagaaacgc 3744961 ctgcgctggc gccaattcgg cttgctccgg cctctaccat tgtgtctaca tcttctttcg 3745021 ttctgacgcc gccagatgct ttcacgccga tatcaggccc tactgttttg cgcattaagg 3745081 cgatatcttc cttcgttgcg ccgcctgtag aaaagcctgt tgatgttttt acgaaatccg 3745141 ctcccgcaga caccgctaaa cggcatgcac gttctttttc ttcatcagtc agaaggcacg 3745201 tttcgataat gactttgaca agcgcttttc cggctacagc ttccactaca ccgcggatat 3745261 cagcttccac cacatcgtct tccttgtctt ttaaagcggc aatattaatg accatatcca 3745321 cttcagtggc gccttttgaa atggcgtctt ttgtttcgaa cgcttttgtt tcagttgtat 3745381 tggcaccgag cgggaagccg atgaccgtac aaacgtcgac tccagttccc ttaagctctt 3745441 ttgcagcaag ctccacccat gtcggattga cacatactga agcaaatttg tatgttttcg 3745501 cttcttcaat tagttttaga atgtccgctt tttgtgtatg cggtttcaaa gctgtatgat 3745561 caattatgtt ggctaatgac atccttcgca cacttccttt tttgttaaga tattttttag 3745621 cataaccgac ttttgaacat atgtaaattg gtaattgaaa ttttgttcaa tgaaaggttt 3745681 gaacgtgtca caaatcatta acaagcgccc tcgcggtatg ctggtcaatg attaaaacgt 3745741 tggcatattt tccggttaat gctccgtgaa tggaagatac ttttctgctt ccgccggcaa 3745801 ctaaaatgga gcgttccttc agtctaaggt cttgaagctc aacaccgatg gtccggtcat 3745861 tgatggcgct gctgcaaata ttccctttcg catcaaaaaa gcgtgaacaa atatccccga 3745921 cggcctgttt tttcagcagg gctttctctt cttcgttaaa atatccgagc cgaaacaaca 3745981 gcgcttcatc acggacagtc ccgaccgtaa agagagcgat attcgcctgc ttgcccatct 3746041 caatgatccg ttcaatatga cggtctttct ccaccattcg cttcacatcc gcattatcaa 3746101 acacgacggg aagcgggaga tagcgcggca tcgtttgaaa agcctctgca aacagctgaa 3746161 tcgtttcagc cgaatacgtg tttacccggg aatggctgat gccgcctttc agctggacga 3746221 cctcgacgcc ttttacctgc ttcggctgca tgttttgcgc gatttgatac atggtggttc 3746281 cccagctgac gccgacaatg tcgccgtctt ttaccgtttc atgcatatat tctgcaccat 3746341 agcggcttag gtcatgtgta attcctgcat aatcgggtgt cggggaaaac acaacatgcg 3746401 cctcaaggag cccgtatttc tcttcaagta tggaaccgag cgcatccaaa tcctcaaaag 3746461 ggtccatgac gcgaatctgg acataccctt tttcctttgc atattgcagc agccgggaaa 3746521 cggttggcct tgaaatgttg agctgctcag caatttgctg ctgactgtag tcagactgat 3746581 agtaaagcct tgccgcttct atgcttaatt gctgtttttc ccgatccatt ctgcacctcc 3746641 ctgtggatca gtcctgataa aactgctttt gatttgcttt tattatacag gctggcgccg 3746701 gctttcatcc acctgatttc taagaaactg aaaaacgctc tgggcgcgga cctgcccaga 3746761 gcttacttct cccaagtcat atgctgataa atgcctttca taatggcgta cattccatat 3746821 aggatcaggc ctaatgccaa tatagacaga atcaatttgc catgcggctg ctgcgcgagt 3746881 tctgcgagcg cgccgtcaaa gcctcttgtg tcgtcgggat cagcggtcat ggctgtcttg 3746941 atgagaaaat agccgatagc cgagaaaata atggcccggg cgatattgcc tgcgcgtcct 3747001 gtgtttttcg tgatgcatat catctgtttg ttcatttttg atgtatcgaa ttctttcata 3747061 aaagcagccc gaacgccttt cataaattga acaatcgcaa atacgataaa acccgcaccc 3747121 gtaagccctg tgagccattg gccgaacggc tgcgccaata cataagcgga ccacgtctgt 3747181 tctgaagtgc cgccgtcccc ttggccaaac acaaatcgca aggcattcca agcgatggat 3747241 gtgtaaacag cggcactgaa aaagtttcct attctccgcg acaggcctcg cctgctgttt 3747301 ccgtgcccct ccgtgtcctt gatcgcgctt aacaccatcc agatcacata gccgataagg 3747361 ccgatgccta taaaaaaaag caatagtgac ccatacggca tgcgtgatag cgtttggaga 3747421 gctccgctcg aatctttggc gcggcctgcc ccggcagccg tcataaaagc caaaacccca 3747481 agcagaataa aaacgccgcc gaatgcaaaa taaccaagcc tcccgaatcg tttgatccaa 3747541 ggcttggttt cctgttttat ttttgacatg taccggtctt tcaccgccat gtgtccaacc 3747601 ctctttcaca gaaatcttta ctgtaacatt cccgattgaa caaagttgaa acagctcctg 3747661 cctcagctat ggctggctga gatacgtttt tgctgtttag ctgattgtgc aggtgtcatc 3747721 caagcagccg ctgcggcagc tgtgactccg cctgctaatt tcccaatgat catggccgcc 3747781 gccatttctt ttttcattcc agctacaaaa ccgagatggc tgccgagtac aaaggcgccg 3747841 ctgaccgcaa acgcgacatt gatgaccttt cctctcggcg tcatatcctt taatgaagcc 3747901 agcattggga tatgatgcgc caaagaggtc actaagcctg ctgttgctgt ctcatctaaa 3747961 tgaaggcatt tccccagagc ctgaagcggt tttttaaagg tttttgtaat aaatgccgtc 3748021 atcgggaacg cccctgccag agcaatggcg atggtccctg tcgtttgtat ccctgtctcg 3748081 acattctcca ttcccggaat cagcacaatg ccggtcatcg tttcaacaga aacagctgca 3748141 agcccgataa tcgcaaccat actgaccgct ttcccgaaga gatgaaacaa ctgaatcatt 3748201 ctgtcggtgt atcgccataa cccaaaagcg atgacagcag ataacagact cgggatcaga 3748261 agatttttac ctatcatgcc gatgtcaaag cctgcgcata atccgccgat taagcaaccg 3748321 atcggcactg tgcacagccc gattaatatg cctttcgcaa aatacggatg atcctctttt 3748381 tcgatgatgc caagagcgac gggaatcgtg aagacgattg ccggccccat cattgttcct 3748441 aaaaacaccc atgaaaacag cccggcctgc ggatctttcg ccatttctcc agccagcgca 3748501 tatcctccca tatcaatcgc caaaatggtg ttcgcaaagg aagaaggatc cgcgccaatc 3748561 gctgtgtaaa acggagcaac aatgggaatc aagattgctg ccagcacggg cgccagcgat 3748621 acaattccga tcatggacag cgccagcggc cccatagcct taaagccgtc cgcaaaccgc 3748681 tcgcctagcc cccatctgtt tcccaaacaa taatccgctg ctccccatag taaaaaggca 3748741 gccaaaatga atacaaccgc gtcattcacc gtcatggttt tctccttttt caaacgtatg 3748801 attggtttta tcatatcatc tgaaatcacc gaatagagtt gatcttattc aatatgagct 3748861 aaaaattctt ttatatcggc tttttcaacg gctgttataa tgcgtcgcgc tttttcttgc 3748921 gggaccgtta atgtcaattt ttctattatg tcttcttcag acagctcatt tcctggtgcc 3748981 ccttttgggc agtccacacg cgcttcgcaa atccggccgt ctgataaata ggcccggaca 3749041 atcgtgaaac ggccttttgg aacggcatga ggagccggct gaatagcatt gtcatatacg 3749101 cgctgaattc gccccattgt cgtttgaacc ccgtttggga tcggctggct gctgaaatgt 3749161 tcaacggtca ggccgtgtcc atgcaaagca agagcaatca catattcaac gctgaaacgg 3749221 ccttcctctc cagcttttgg agatctttcc gtcaatgcag catctccgcc tggcggaaat 3749281 atcacttcaa tacgttcggt attggcagca gaaatggttt cttcggagat aagctgtcgt 3749341 accgcatctg cagcatggtg tgccgcggaa caaaatggat agattttaaa ccatagaccc 3749401 ggctgcacaa ttctccacgg tgccccccaa tcgtttagca aagtgtgttg tgctttctca 3749461 acgtcaccgt acagactgaa gaaaccagtt tctccatcaa gtgccgtgcg ggacccgcca 3749521 aattctgatt gggccagctt aacggccagc aagccagcct gagccgccaa accggcgtgc 3749581 agcggtttca tttctgttcc aaattgcacc ctcatcccag cagattgcgt agccgcaaaa 3749641 ccaattgctt tttccaactc ttcctgagtc agctcctcag cataacctac ggcgcaggca 3749701 gcagcgatgg caccaagcgt acctgtatta tgccagccct tctcatagtg gcggctgcca 3749761 attgattctc ccagccgtgc catcacttca acaccaacaa cataagcgcc aagaagccgc 3749821 tcgtcatgtc cgcgagcggc agaagcaata agggccggta cgatgactgc actggggtgt 3749881 cctcttacat cggagtggac atcatcaaaa tccaatgcat gggcgataaa tccattgagc 3749941 atcgcggatt gtaatggcgc ggcctttttg ccctgtccga taacaggaac aaggggccgg 3750001 cctccttcat cctctatcag acggaggagc ttttgaattc ctttatcttc tcttcctgcg 3750061 aatgaagcgg cagtaaaatc aagtaatccc ttttttgctt cgtgaatcgc gtcaactgaa 3750121 tgctcaggtt gtgacgttct cacagcctct gcaagacctg ctgtcagccc ttgtttgctc 3750181 atttgatggt ctccaataca ataaccgcca gctccgcaaa gtattgagag gcaaccgtaa 3750241 gggcttcttc atccagtgta aaggccggat gatgccactc ctccgtcccg ttcgttccca 3750301 tccagacaaa aaatcccgga atcttctctt gatacagagc gaagtcttct ccgcccggag 3750361 actgctcagc gtgaacggtt tgatagccaa gccgtgccgc agcttcggat gccgcattca 3750421 aaaatgtgcc gtcattctga acggaaggca aataaggaaa ccacttgaat tctgcttgtg 3750481 ccccatagcc cgctgcaatt ccttcagcca ctcgtctcat atgctcggga acagcctgcc 3750541 tcgcttcttt ttgaaaggtt cgaaccgtcc cctccatttc agcttggtct ggaattacgt 3750601 tccacgaggt gcccgcctgt actcttgtga tactgacgac tgcgttttgc agtgagctga 3750661 tattgcggct gaccacagat tgcagcccgc tgatgatttg tccggctgca gcgattggat 3750721 caatactgtt atttgggatg ccggcgtgcc cgcctttccc tttgatgacg atctcaaatc 3750781 ggtcaacact tgccatgagc ggaccttcct ttacaccaat ggtcccgaca ggcagatccg 3750841 gcttattgtg catgccgaaa atcgcagaaa cgccattaag tacgccagct tctagaacct 3750901 ttcttgctcc tgcggcaatt tcttcggccg gctgaaagat aaagcggact gtacctttca 3750961 gctcggccct tctttgattc agcaacatcg ctgtgccaat aatagaagca gtatgaaaat 3751021 cgtgtccgca cgcatgcatt gtgccatcaa ccttagatgc aaatggaaga ttcgtctgtt 3751081 cttggatcgg gagcgcgtca atgtccgctc gtattgctat cacggggccg tcttcccgtc 3751141 ctttgatttc tgcaatcaca ccagtcttca attgagggac atcaagtatt tcgatttgct 3751201 cctcctcaag ccaacggcgg atttttttcg tcgtttcaac ctcttgaaat gacagttcag 3751261 gatgttcatg aagatcacgc cgcatattga ttaaacgggt atgaaacgct ttgtcggcca 3751321 ttgttcttct ccccttctta tataagctct gcaggctctc ccacctgctt gataaatcgt 3751381 ttcgtccgtt cgtttttcgg atggtcaaac agttcctctg gcgttccctg ctcgataata 3751441 tggccgtctg ccataaaaat cacttgatca gcaacctctt ttgcaaacgc catttcgtgt 3751501 gtaacaatga tcatcgttgt ttgtttttcc gcaatggact tgatgacctg aagcacccct 3751561 gtgacgagct cagggtcaag cgctgacgtt ggttcatcca gcaaaatcgc atgcggattg 3751621 accgcaagcg cccgcgcaat gccgattcgc tgctgctggc cgccggacat tgtgattgga 3751681 tagctgtcag ccttatgctc cagaccgact tgtttcagaa tctccattcc aatacgtttc 3751741 gcttcgtcgc gtggtttatg ttgagccacg attaaagctt ctgtaatgtt ttgcagagcc 3751801 gttttatttt taaacagatt gtagttttga aagaccatgg ccgtttgctg gcgaagccga 3751861 tgtgcttcct tgcgtgtaaa cttttccgca ttcagtttgg cttctccgat ttcaataagg 3751921 ccttgatccg gacgctctaa tagatttaag caccggagaa gcgttgattt tccggaaccg 3751981 gacggaccga tgattgccac cacttctccg cgtttcactt ctagatcgat tccgtcgagc 3752041 acgacgagat ctttaaacgc tttgcgaata ttttttactg ttatcaactg atttcacctc 3752101 taagtccggt atggcttgct catggcacgt tcaaacaagt cctgcaaaat gctgtagata 3752161 atggtaagaa cccaatagac gatcgcaacc gccaaatacg tctcaaaata tttgaggttt 3752221 cctgaagcgt acatcttccc ttgggcgaac atctccatga cccctaatgt aaaggccagt 3752281 gacgtttctt tcaggagccc gataaatgta ttgcccgttg ccggaatcgc atttcggatc 3752341 gcttgcggca aaataatccg tctgtatgcc tgaaattttg tcataccgac agacaggcac 3752401 gcctccagct gcccgtcatc aacagaattg agggcggccc ggaagatttc tgccaaataa 3752461 gctgcgtttt ttaagcttaa cccgatgatg gcagctgtga gagctgtcat tttgctcatc 3752521 tctggaaata gctgcggcag cccgtaatag attaagaaca gctgtacaag tgtcggcacg 3752581 cctcggaaaa aggatatata cagctttgac agctgatgaa gcactggaat tttgtttttt 3752641 gtaatgagtg cgagaataag tcctccgata atggcaaaaa tcatagctgc tattgccata 3752701 aacaaggtga tcggaagggc ctgaattaaa gtcgggaacg ctgatatcat gaattcccaa 3752761 tcaatcgtgt tcattctggt gagtcaccgc cgtttcttaa tgcttctgtt ctactgtgat 3752821 atcttcatta aagtattttt cagagagttt tttcagtgtt ccgtctttac gcaattcatc 3752881 tagggcctta ttgacttttt tgcggagctt gtcgtgcgca tcgtccttgg caaatgggaa 3752941 tgcaacctgt tcgtaaacaa tcggatctcc tgcaagcttt aatggcaaac cggtcttctt 3753001 gatttgcgcg atcaatacag ttcggctgtt gacataagcg tctacacggc cgtacgcaac 3753061 atccttcagc gtaccctctt gtgtttcgta cgttttgata ttgatttttt tatcaggatc 3753121 tttgctttca aggtttttcg cgtggtttga accgagaacg gctgcgactg tcttgccttt 3753181 taaatcgtct actgatttga tgtctgtatt gtcttttttg acgacaatct gtgttcccgc 3753241 ataagcgtat ggtttcgtaa agttatacgt ttccttacgt tcgtctgtca cagctacctg 3753301 gttggaaatg gtgtcaagct tgcctgtttg aagctctccc atcagcccgc tgaattcaag 3753361 cagcttccag tccagtttca tgtcaatttt cttagcgact gcttccatca cttccacgtc 3753421 aaagcctgtc agctttccgt tttctttata agcaaatggg taactttgtc ctgtcgcacc 3753481 gacatgaagc acattgtcat cctctttact gctgctgttt ccattgccgc aagctgagag 3753541 caccgctaat aatgcagcaa cgaccagcac tgtccatttt ttcatcttca tttgattttc 3753601 ccgccttttc tatttttata gatcatgtcg caattgtttt ttcatataga ctgtgatatg 3753661 cccttttcca aggtcttgtt cacctgagcg gacatatcct tttcgttcgt acatctcaat 3753721 cagccacgga tgcttatccg ctgttccgag tgagacaaac ggaaccttta acgtatcgcg 3753781 aaggattgtt tcctccagcc attgaagcag ctttgttccg attccttttt taccggtgtc 3753841 ggggtccaca gcaaaccacc agatatgcgg aacgccatac ggtcccggct gttttcccca 3753901 aggcattctc aaggtgatgg tcgcgatgat ccgcccgtct tcttccatga cgtagcaagc 3753961 attttcccga atatttttca gcaccaaatc caaatccgca tgagcagcag caaaacgaat 3754021 gccgagcttt cgaatcggtt cataagcccg caatgtcagc tcgagaagct gttcggcatc 3754081 acgttcaact gcaaggcggt atcgtggctt catctagcgt tcctccttac tttgcatagc 3754141 ggtttaccgg cttttccaaa ccgaagtgct ctcgtaatgt tgtgccttca tattcttttc 3754201 tgaacacgcc gcgctcctgt aaaatcggaa ccacttgatc aacaaacact tcaattcctt 3754261 ctggaagaag cggaggcatg atgttaaacc cgtcacacgc tttcgtatcc acccattcct 3754321 gcatcttgtc ggcgagctgc tccggcgtgc cgacgaagat atggtggcct ctggagcctg 3754381 caacgtattt gtaaagctct cgtatcgtca tattgtcacg ttcagccatc tcctgaacaa 3754441 gcttgaagcg gctcttcacc gcattggaag cttcggcgtc aagcttcggc agcggcccat 3754501 caagcggata tgccgacaaa tcaattccgc ctaagtaatt ttggagaatt tgcagaccga 3754561 cagatgggat aatcagatct tggagctcct tgtatttggc ttgcgctgct tcttctgtat 3754621 cggcaatgat tgggaaaata cccggcataa tggcaatttt ttctggatca cgtccgaatt 3754681 ccgcagcctg ttctttaatg gattgataaa attcttgagc tgattccagg tggttttgtg 3754741 ctgtgaagat cacttcggct gttttggcag ccagcgcttt tccgtctcct gatgatcctg 3754801 cctggataat gaccggctgg ccctgcgggg ttcttgaaac gtttagaggt ccgcgaaccg 3754861 agaaatattc tcctttgtgg ttcagctcat gcattttttc tttgtcaaag aattcacccg 3754921 tttctttatt acggataaag gcgtcctctt cccatgaatc ccaaagcccc tttacaatct 3754981 cgacaaattc ctctgcccgc tgatagcgca aatggtgttc aaggtgcttt tcaccgctga 3755041 aattcagcgc tgttgattca atagatgaag tgacgacgtt ccatccggca cggccattgg 3755101 acagatgatc caatgacgca aactgtctgg caatatggaa tggctcgctg tatgtagtgg 3755161 aggctgttgc tgtcagtccg atttttgatg tgacctgcgc caaagcagag agcagggtga 3755221 atggctcaaa ccttgttaat acatttggat gtgatttgct gtcaattgaa aggctgtccg 3755281 ctaaaaacag catatccagc ttgcctcgct ccgctgtttt cgcaagctct ttaaaataat 3755341 ccaaattcat gctcgcatct gacggcgcgt ccgggtgccg ccaagacgca acatgatggc 3755401 ctgtacctgc taaaaatacc cctaatttga tttgtttctt tttgcttgtc atggcgatac 3755461 tccttttatc atgtttttag gctgaataat ccgaaaaata aactcctata ttcctagtcg 3755521 tttaatatga ataaatcaaa atgtaccttt gtcttggacg tttgtcaatg agttaagatt 3755581 aattttttct attcaagcga aaagaccctt gcgtgaccat gagggaacgg cattgattca 3755641 ttcaactagt gcaacctcta tatcggcaag aaaactgagt ctaatgaagc aaagactcag 3755701 ttttcttcca ataatttcat ataagatttc gccatttcct ttgccttttc ttcgcttttg 3755761 caaaccgcct atccattcag acgccgtaac gattgtataa aaaaacagct gactccagat 3755821 attcaaaccg gaatcagctg attgatgtga attaattaag ctcatgaata ctctcttctg 3755881 ctttagcgga aaacacttta ggctccaaac agtcaaggtc ttcatgaaat aaatttactt 3755941 tttggatttg ccgattgtca tagtggtgga aatagtagtt tccagtttcg ttgcacatca 3756001 cggaagtata ttgcgtataa tgaatttcgt cttcttccgt tatcactgcg ccctttggta 3756061 tcgtcatatt tgccaaaatt tgaaaagcgg ctgttacacc tttcgtttca tcggccgccg 3756121 gctctagatg ttctttcaaa taaacagctc tgacaaaccg ggaaggcggt gtataatccc 3756181 ccggcagacc aacagttcct aagccttggc caaaagcaga aagggctaat ccgcccatct 3756241 ctttgctctc taattgcttc ggtctgattc ctgtatattg ctgcagattg gttacatgcc 3756301 atataaagtc ggggctgttc gtcatgacac caggttgatt atcatagact ttgaggccgt 3756361 ctgctcttgg ttctatcgtc aggtttcggc ccgtccggtc tgacaatatc cagtgaagcg 3756421 gtaaaactgt atccaataga tctaattttt tctctacaat cgttaaagat cgaatctttt 3756481 cttttacgtc ttccaaagac tgacagactg acagcaccca tgtcacaaac tcatgcggga 3756541 caatgtgaac ggtatcttcc cgtatcgttt tttcgtactc cgcatagccc ggaaaataaa 3756601 gcgccgcaca agataaaccg ctttcattaa tgccgtcggc aaataatata tttccaagtt 3756661 ttctccccat accgataaac gcgtactgtg tctgatgggc ccttccgtca gcttcactgt 3756721 tccagctgta acggcgcgga tagagaatca cctctgtccc cagctgaaat gcaaaatcca 3756781 ttgttcttgc taatacatgt ttacggtcag cagtttccaa tgtaagactt gtgcacattt 3756841 gatcagtccc cttttcaatt cagattaata tcatacatat tgtgaacgaa ttggttttat 3756901 cagcataacg aaagtcaaat cgattcgtca aagaattgac attacatcaa ataaaacgaa 3756961 aaaatccagc ctttagaagg ctggattttt tattatttag ccaaaacaag ctcgtgaatc 3757021 gcatgtgcaa cgccatgttc attattggag cgtgtttgaa agtttgctgc ttccaatact 3757081 tctgggatgg cgtttgccat ggcaaccccg cagcccgccc attcgatcat tgtcaggtcg 3757141 ttcccgttgt cgcctatgca catgacttcc gcctgttcaa ttccaagcag ctgagccagc 3757201 tggcgtacag catttccttt gctggcttcc gagtgcagaa tttcataaaa gaaaggcgcg 3757261 cttctgacca ttgtatattt ttctctcacg tcttttggaa tcgatgtaat gacgcggctt 3757321 aagttctccg gtttatcaat aaacatcact ttcgggatga ggatatcttt tggcacctcg 3757381 tcaatcttgc ggaaatgaag cggcacctgt gtcacatagg attcgtatac ggtaaattcg 3757441 ctaatatccc ggttaggcgt atacaaatta gatgagtcaa agaaatgcat cggcgtcttc 3757501 agctctaagc tcaggtcata taatgaagtc aaatcatcat aaccgagaga cagctctgag 3757561 accacttcat ttgtatgcgt attttgaaca agtgctccat tatacgcaat aacatagtcg 3757621 ccttcttcaa ttaaattcag ttcatctaaa tatctctgca cacccccgat aggccggccg 3757681 gtgcaaagca caattttgac accttccgct tttgccgcgt gaagggcgtc gcggacctcc 3757741 tctgttactt catgatgatc atttaaaagt gttccatcca tatcaattgc aattagtttg 3757801 tacatcctgc atctccttca tgtcgttttc aggctatagt cccatcatat cgttttttct 3757861 ttttgatatt caaccggaag agatggtttt ctccggattc tgtttagacg ccgcccttgt 3757921 cttcggatac gcaagcgcgg tttccgcttt ctttctgcct tgacgccgtt ttctgctttt 3757981 ttctgtttca tcagcagaaa gccggcagct agaaaaggaa tgccggttat attcaagatg 3758041 gcaagcttca cacccgccgc gatgaaaaag aacccccatg aagatgatgg attccgtctg 3758101 atcatgacgt aagccgccat ttccagaacg atcaggatgg catgaagcac tatgccataa 3758161 atcagcaata caagggcaaa aaacaaaaca taattcacga ttgcccctga gtacatcata 3758221 gcgcgcatca tttgtataaa cgataaggac tgcatggagc cgctgatgac attagggtta 3758281 tagatcgtat agtcactaaa taaatgtttg actttgagaa aagcccataa tataaatatc 3758341 cattgaatga tatgtaaaac aagccccgct gccaccagtc tttcagcttt ttgatttctc 3758401 atctttctcc tccctgccgg tctttgattc gattcttgtc atcgtttttc tctgtccatt 3758461 ttgctcccat atcaatgtcc cgttttctcc tcttttcagc gtgcttttga gcggataata 3758521 agggccgagg tactgaatct cgatagaccc gtcagtgctt tgggaaatca ccttgtatgc 3758581 cataaaaggc agctgtacct ctcctcttcc ttccatcact tccgtttcca caacctcgtc 3758641 ttcggtaaat gtgactgttg ctgatttcac accgtccgtt ggcccggggg cacgcccctc 3758701 atcccacgtt ccgtaataaa acggcgtctc ttctttttgc tgctggcagc ccgataccat 3758761 gatgcataca gcaattaaaa acaaaatgcc atatttgttt ctcaagggga tcaccattct 3758821 ttcctccttt tttgggcgaa tgccgtgcca ctgtgccaat gactacataa gttataagga 3758881 attcacccac aaggagactg atcacatgaa cccttatcaa tattacagcc ctcagctgcc 3758941 tcagcaggaa ccttactata gccactatga gtacaatcct tatccgcagc aggatgtata 3759001 cgatccatac caaatggaca gacagccggc attggaaaga agaatcgcag cacttgaacg 3759061 gcaaaatgaa cagcagtcaa gagaattaac ccgtctgaca aacgaagacc gccgtcaaaa 3759121 tcgggaaatt gcacggattg ccgaacaggt caatcagtta agccaggctg ttgaacgcca 3759181 tacacgccgc ctaaatcggc tcaatcagcg cctccgtaca gtagaaaacc ggctgaatat 3759241 cccatttact gcaggggaag gcggtttctg agcgaaacaa agaaaaaaag cggaatacga 3759301 ttctcccatc tcagggtttc gttttccgca tttcttatat gttaaaacgg aacatttaca 3759361 taaaaagggt ttgtacccag tatacaatct ttaccgtttt cattcaaaga tagaggggct 3759421 gaggaaaata attgtagttc ctctttgacg gaatttcttt tcattcaagt tgcatgataa 3759481 taccgactca cgtcaatcga tacatggagg gatcattcat gcataataca caacacggct 3759541 tgcagcagct gaaccaatgc cgccaaactg ctcagcagct cattcagcaa acacagcaaa 3759601 gcagccagca atatcgccaa atgcttcatc aggaacagca aaacatccaa atgctgcagc 3759661 agattctaaa ccacgaacaa caagctgcac ataccattca gcaagcactg cacgggcatg 3759721 acatggcgat tcaaaagtgc cagcaggttg tcaacatgtg caaccaaatg caacaggaac 3759781 ttactggaca atccagcgtc atgaatacga atgtgtctac acttccattc ggccaaaaca 3759841 cgacatttca gcagcaatcc taccagcagt aacatataaa aagctcaaca caatgcgagt 3759901 gttgagcttt ttttcttact gttctttgcg aatatgtata tcctgaatag actgtttcgg 3759961 tgcatgaaat ctgctctcgg cttcacttct tgcctcggca aaagcccgcg cctccacatg 3760021 atctttgtag acatccagct gaatcaaata cagcgggcgc actttaaatc catgaataat 3760081 ggttaccgcc cataacggga ccacaataaa aacaccgggc agatcgggca aaacaaaacc 3760141 aaacgcaaaa atgaaaaaat aaatgatgcc gtacatgatc cactttctat ttctaacctt 3760201 gatgccaata aataaaaagg caaaaaaact ggtaatggca aaaggcatga aaataaacag 3760261 catccaccag ctatgcagcc attcccaagc ggcacctctt tttgtaattc ccatattttt 3760321 ctcctcctat ttacctataa taatcgatta ggcacaccgc gtcacccata aacgggaaaa 3760381 actttctccc ttaaaaatag tgatagacgg agaacaggtt tcttgctata ttattaattg 3760441 ataatgataa tcattactaa tctattgaga tacatagtgg gagggttctt gatgaaaaag 3760501 aacatattgc tcgtgggcat gcttgtgctg cttctcatgt ttgtcagcgc ttgcagcggc 3760561 acggcttcta aagggagctc aagcgattct gcttccgaaa aaacagaaat gagaacatac 3760621 aaatcaccaa aagggaacgt caacattcct gcacatccga aacgcatcgt cactgatttt 3760681 tatgccggtg aattgctgtc tgtcggggcc aatgtggtcg gctcaggctc atggtcattt 3760741 gataatccgt ttttaaaatc aaagctgaaa aatgtgaagg atgttggtga tccaataagc 3760801 gttgaaaaag tgatggagct tcagcctgac ttaattgttg tcatgaatga agagaatgtt 3760861 gataaattaa agaaaatcgc tccgactgtt gtcatacctt ataacacagc gaaaaacgta 3760921 gaagacacag tcagcatgtt cggagatatc gccggagcga aagaccaagc aaaatccttt 3760981 atggctgact ttaacaaaaa agcggaagca gctaagaaga aaattgccgg cgtcatcgac 3761041 aaagatgcaa ccttcggcat ttatgaaaac acagacaagg gcgaattctg ggtgttcaat 3761101 gacaatggcg gacgcggcgg ccaagctgta tacaatgcac ttgggttaaa agcgcctgaa 3761161 aaaattgagc aagatgtcat caaaaaagga gagatgaaac agctctctca agaggttatt 3761221 cctgagtatg ccgcagatta tatgttcatt acggattaca acccgaaagg cgaaagcaaa 3761281 acactcgaca agctggagaa ttcctccatt tggaaaaatc ttgacgctgt taaacataat 3761341 cgcgtgttta tcaatgactt tgactcgttc tacccgtacg acccgatttc tgtcagcaaa 3761401 caggtggata tcatcaccga catgctgatc aaacgggccg aagaaaataa aaaataaaaa 3761461 aacggcacag tcatgacgct gtgccgtttt ttatgattca ctttaatttt gactgtacgg 3761521 agtccggcat atcttcaaac ttgacttctt cccaagtctc gacatacttt cctttcgcct 3761581 tcaccttcaa atacgcgttc ttccgaagct ctttgccggc gaaaaaggtc acttcttctt 3761641 ttttcccgga tgcattatat ccgtctaatg tatattcagt accgcccgga ctaagatgtc 3761701 tgccatctcg atcaatctga acatagacat cttgctggtg aataaacgga ttaaatctgt 3761761 ctgtaacatc gttatgaaaa aagagaagcc cgcatattac ggcagcagcc gccaagacgg 3761821 ccaggattgc cattgctttt ttcatctttg cactcccctt acttgttcat ttttttcaaa 3761881 tagcttgacc gcaccgcgag gaagaataga agctgaaaaa tgaaaaaccc tccgatggtg 3761941 agactgagcg gccccgctac atcggaatat ccttccacag ccaatgttct caaggcaaac 3762001 agtgtatgca tgacggcaat gacaaatgga aagaagaaaa gaatcgccaa ttgtattgtc 3762061 acgctttgcg ccatttctcg ctcactcagg ccgattttgg ccagtgaacg gtagcgctcc 3762121 cggtcttcat ctaaatcagt gaacagcctg aaatataaga aacttgctgc cgcgacaaag 3762181 aatacaattg cgataaacag gccgataaat agactcaggc tcggcagctg caccgtatca 3762241 tagtaagtcc ccgcttttga agcaaaatca gaatgcacgt cgatataatt gccgtaaatc 3762301 tcattttgca aggattggct gatctcaaga ctgtctttcc aatgatcata gctgtagccg 3762361 tataatgacg ctttatcacc gagtgatttc agctgatcaa aggtttgatc attcaccgcg 3762421 atgatagcat tcaatgagat cagcggtttt ttgacttctt ttaccgacag tttttgatca 3762481 gacagctccc ctttttggtt cagcagcttc agctgatccg gcgcttcgtt tttgaaattg 3762541 cggtcatacg ttcccgggaa atagacagcc tcgtcttctt tcaggccgtt cactttgaca 3762601 tggaagtatt ttgccgcatc cgattcactg atcatgtaaa cagggggaac agtttctcct 3762661 tcctgatagc gaacatagga aacatctatt ttgtctttcg tatacgtaaa accgtgtgtt 3762721 ttcagttcat ggtcaatatc tttcaaatga gtctgttctt ttggattgtt gctgtaagat 3762781 aaatactcca tttcataagc ggactcttcc gctccgacgg tcgatttgta cattgcgagc 3762841 acgcctgtcg cagtaaacgc aaccgcggaa ataatgctga caataaagaa caggcgggcg 3762901 ttgtctttta gacgatagac aaggtcagaa acccaaatga tgtttttccc gcgcagataa 3762961 aaggttttcc acttcttcag cgcgcgcaga atccatatgc tgctttggct gaaaaagaaa 3763021 tatgttccga taacggtgag cagtaaaatg ataaacggtt cggccccgtg gacattgcct 3763081 ttaagaacca tgccgtaccc gccgcacaga caggcgatgc cgaataagga cagaagcacg 3763141 gacggcttag gctccggttt aaccttgcca gtgcccttta ttaatttgat aaccgtattt 3763201 gatctgacaa aaaggatcgt aaactgcgat aaaaagaaaa ataagagcag aaatccgcag 3763261 gccgtaatac cgagcgcttt ccaaggcata tacaaaggca gcgcgtccat ttctaaaata 3763321 taagcgccga ccgtaaagaa cgtctttgaa aaaatgaatc ctccgataat accggctgca 3763381 attgacatga cgccgatgat catattttcc gcagtaatga gctttctcag ctgccccggc 3763441 gtgatgccct gcatgagcag aatgccgaat tctttatttc tcgatttcaa aaatgcatta 3763501 accgaataca gaacaaataa gaaagaaaaa acaaagatca tccattccgc ggcggttaag 3763561 ccttttttgg cgatgttatt caggtagcct tcctttaatg ccggatgaaa caggaacatc 3763621 gcaaaggtaa agaaaatcaa aacggaaaag gcgctgctta aaaagaatgc aagataggcc 3763681 cttttgtttc tcgtgacgtt tttataagcg aactgaagaa aggtcatttg cgtttccccc 3763741 cagcatagac agcacatcga gaatttgttc ataaaatact tggcggtttt ccccgcggta 3763801 aatctcatta aacagttcgc cgtcttttat aaagatgacg cggcggcagt agcttgccga 3763861 aaccggatcg tgggtcacca tcaaagccgt gacatgatca tcccgattca ggctctgcaa 3763921 cgtttccatg acgtcttttg tcgctttgga atcaaggttt ccagttggtt catcggccag 3763981 aatgagtgac ggcttatgaa tgaccgctct tgcgatggcg gcccgctggc gctggcctcc 3764041 ggatacttca aacgtccgct tgttaagcag gttttcgata ccgagctttg ccgcgatgcc 3764101 gtgcagtttt tcttccatta cagacggcgc ttctttttca agcgttaacg gcagcatgat 3764161 attttcaccg atcgtcagcg tatccagaag gttgaaatcc tgaaacacaa atccgagctg 3764221 cttgcggcgg aaatgagcga gctttgtccg cttcaggcga tgcgggtttt ctccgttaat 3764281 caggatatcg cctgaatctg gacggtcaat cgttgaaatg atattcaaaa gcgttgtttt 3764341 tccggacccg gacggcccca tcaccgccgt gaactcgcct tcttctattg aaaatgaaat 3764401 ttgctttaag gcctgatagg acacttgtcc tttataggtt ttatttatat gtttgacttc 3764461 aagcatattc gccatgaaaa tcctccttat ggttttattc ttgttgatct gggctgcttt 3764521 catgtagtgc cgggacgttc aacataaaaa tccccttgac ataaatccat gttatcaagg 3764581 ggaaacaaag cgggctatgt tgttttctta acgcagcctt acatttttgt aagaaatgaa 3764641 aatcgaactg atgtcccttc accgggagac gagctgatgt ccaccgtatg attgagctta 3764701 tctgtaattt ctttgacgag atggaggccg attcccgtag attcttggaa acgccgcccg 3764761 ttttcacccg tgtaataagg gtcaaacacc cgcttgatgt cttgtgaggg aatcccgaca 3764821 ccgtaatctt tgacttcaag caccgtcctg tcttcatcgc agaagacatt cagctcaagt 3764881 ctgtcactct tgcccgctga atacttgacc gcatttgtga ccacttggcc aatcgcaaat 3764941 ttgagccatt tggcatcggt gtaaatctga tgatcatcgc aaacgttcat tttcggataa 3765001 acgcgatatt gaataaaaaa tcgtttatag ctttgaataa ctgattggag aagctcggac 3765061 agggaaaccg cttcgatttt aaaatcccgt tcaaacaggt cgagccttga agaataaaga 3765121 agcgtctcca gcccgaattc aatctgccgg acttcttttt tgatttgttc aaaaacgggc 3765181 tcatcctctt cttgaatgat taaattaatg accgacagcg gcgtctttac ttggtgcacc 3765241 cattgattca tatacgtcac ccgcgcgtca agcttggctt cggtctcatg gagcttctgg 3765301 tgctgcagcc ggatcagctc catctgcttt tcatacagct ctgaacagaa cactgaagaa 3765361 ccgagatacg ggatatccgt cccttcctgc cccgagctga gccaatgata cacgccgcgg 3765421 tctttgtacc agcgataggc aagatagccc gccaaaataa gaagctgcac gcccaatatg 3765481 taaaacaagt gagaaaaaga atgaagaccc gcaaaccagt aataaaagaa gacaaacagc 3765541 ccttgaagga gaaaaagcag aatcagcact gcatgagacc ggagaaacag cttcatgact 3765601 gcgccctcag ctggtagcct tcgccccgca ccgcttcaat agaaacaggc gcattcagct 3765661 cccgcagttt ttttctgagc cgcgtgatat acacgttaag tgtattatca tcgatgaata 3765721 tgtcggtgtc ccacgtcttt tccatgagac ggtcccgact cgtcaccttt tctccccgct 3765781 caagcagcac ttccaaaagc ttgctttctt ttttagaaag ctcacttttt tcatcctgaa 3765841 aacgcagttc aaaccgttcc acaaagagct gaacgccggc atattcaacc actttctctc 3765901 cctgctttgc ggcgtactcc ccgtacgccc tccggatctg gcttttgatt ttcgcaagca 3765961 caatatcata agaaaacggt ttttcgatat aatcgtctcc cccattttca atcgccatca 3766021 cctgatccat ttccccgctt ctggcagaaa taaagatgat cgggcttgtg gagtgctggc 3766081 ggatctgccg gcaccaataa tatccgtcat atgccggcaa attgatatca agcagcacca 3766141 catcgggctt ttcccgcaaa aagacatcaa gaacagctgt aaaatccgcg gcgaccactg 3766201 tttgatatcc gtatttttca aggtaattct gcaatagtcc gcgaatgtct tcactgtctt 3766261 ccacaatcat gattttattc aaactgaacc actcccgttt cttacactgc tgccatcatc 3766321 ataatcgttt tgggcgtatg gacgcaacac cgcacaaaaa aaccgccatc tcggcggttt 3766381 ctggtctctt tagccgacct gctgcttagc tgctttaccg gctgatccga actctctcat 3766441 tttgcttcgc actgtctctt ccacggcttc aatgccgggt gtcaaatagc cgcgcggttc 3766501 gtacagatcg ctgttttcct gaaacatgcg gcgtgtttcg tctgtccacg ctaccataca 3766561 ttccgtattg atattgatct tcgcgtggcc gagcgtgatg gcttttttga tctgatcctg 3766621 cggaatcccg gatgccccgt gaagaacgag gggaatatca gtcatgcggg agatagcctc 3766681 catttcctta aatccgagat tcggctcacc ctgatatttg ccgtgtacag agccgagggc 3766741 ggcggccagc gcgtcgatat tggtttcttt aacgatccgc tcacattccg tgatatccgc 3766801 atagcggacc ccgccgacca gtccgtcttc cattccgccg accgtgccga cttcggcttc 3766861 tactgacacg ccgtgttttg cggcataatc ggtgacttct tttgtcatcg cgatattctc 3766921 gtcaatcggc tgatgggagc cgtcaatcat cactgagctg aatccggcat caatggcctg 3766981 tctgcagcgt tccgcactgc tgccgtgatc gagatgaagc acgaccggaa cggtaatcgc 3767041 catgtcctct attaacgcgc cgaccatggc ggcaatcgtt ttaaatccgc ctaaatagtc 3767101 gaccaggcga tcggaagccg cggcgatgac cggtgattgc tccttttgcg ccgcctgcaa 3767161 aatcgccttc gtccattgca ggccgttgat attaaactgg ccaattgcat attgctcccg 3767221 ctttgcatct tcaagaagct ctttcatcga tacaaaagcc atattcaccc ctcctttatc 3767281 cattacatgc tgaagtattt tgatacgaca tccactgttg tttttttcgc tgtttgaatg 3767341 gcttcctcag cagtcagctt atagtattca ggccggaaga gctcaaccga aacaacatca 3767401 gagaagccga tttccttcag tgctgataag tgggcatcta agtcaattgc cccttgtccc 3767461 ggccatacac gatcctcatc tgttaaaaag ccgattggga aatcttctgt atcatcaata 3767521 tgatagatga agattttctt tccgtccgcc tgctttaagc tctcaatatt tgaacccatt 3767581 gcatggaagt gaaaactgtc aaggacaagc ccgacattgt cacggttaac tgtgtttaca 3767641 atctcatacg cctgttcaaa cgtattgacc gtacattgcg gatggccgac aaactcaagc 3767701 gcgattttta cgccgtacgg ctccgcgata tctgacagct cagtcagcac gtctacactg 3767761 ctctttttga tctcttcttt tacaatcttc tgctctgtca caagcggaac ggccaccaca 3767821 tatttcacac cgagggtttt gcatgtttcc atcatgcctt taaattcagt gatgatctcg 3767881 ttgtgaccct tttcatcacg gttgttgaag aaaacgagtg cgtttaaggc aagcggtttg 3767941 atgtggtggg tttgaaaata ttccgcaagg tcatccaatg aatgatcttt taagtactcc 3768001 ggcagcttat ccatagtacg gatttcaata taatcatagc catgcttttc gcatagttct 3768061 aaatccagtt taaggtttga gttttccaat gttgtcgctt cattaaaaca aagtttcatg 3768121 ccagactccc ccatctgcgt tttagatatg aagggagttc ggcaggaagg ctgtcgccat 3768181 atcccgccga actccatgct cagcttatgc cagacctaat tcttctttca ttttcttaag 3768241 cataaatcgg cttgattcat ccgctctttc atcgacccaa gcaaatacgg cattcgtcgc 3768301 aattccgtcg aacttcatct ctctcagttt tctgaaaatc gtatcaaaat caacctcgcc 3768361 ttggccaatg tccaaatgct ggtgaaccgt tactttcgcg tcaggcggat tgacgatgta 3768421 gcgaaggcca tgagccgctt tatgattata ggtatctgca aataaaacat gtgtgaggcg 3768481 gtcgccggct tcgtcaaaca tggtctcgat gtcgcctttg ccgtcatcat agaagaacgt 3768541 atgcgcagtc gagtagacaa gattgatcca atccttgtca agcgcgcgga tcatatccat 3768601 cgcacctttg tgcgtttcga taaaatcata tggatgggct tgaagattga gtttaatgcc 3768661 ttctttttca aagactggca gaagctcatc catggatttg ataaattttt cttcacttgt 3768721 taaaggatca tattttgaac cgctgaattc gctgttcatc aaatccactt caagttcaac 3768781 cgcaatttcg attgcccgtt tccagttgcg cactgctgcc tggcggcggt cttcatcggg 3768841 tcccgcccag tggtaaagag gaagaagcga tgaaagctta acacctgtat ctcttaaaag 3768901 gcgctttaat tgtttgatct ttgctgaatc gactttcgga tatttataaa acgggcaaaa 3768961 atcctcgcgc ggcgataatt cgatatattc atagccgagc tctgccgttt tatagaccat 3769021 ttcctctaaa gttaaatcat cacgatacat ggatggatcc aatgctaact tcatattttc 3769081 actcctctgt tttttagttt tgaactgttg taaaagattg atagaattcc ggtttttcct 3769141 tcaattcaac cttttctttt tgtccagatt cctgggcttt tacacacgcg tcagtcgtga 3769201 cagcagcaat atagccgtcc catgccgtcg gtccgctgac ctcgcctttc ttttgaatcg 3769261 aatcaataaa gtcttggatt tccacatcat acgcagcgac aaagcgtctc tgccaatcca 3769321 tcaaaatatc agtgctgaat ctgccttctt ttctcaagct gatgcttgat ggctcgggaa 3769381 gcttgatgat gccgtcttct ccgacgattt cacattgaat gtcatagccg tatttacagt 3769441 tcacatagat ttcagcattg atgacgatac cgccttttgt ttcaatcacg acgatttgcg 3769501 gatcttttaa atgtggaagc gcgttttttg attttttcgg atagatgact tgaacggact 3769561 cgtagtcatc attgacgagc cagtggagca cgtcaatttc atgaacaagc gtgtcgacta 3769621 cagccatatc cgttgtatag ttatctccta cagtcgggtt gcggtgcgcg cagtgaatca 3769681 taagaggctc gccgatgaca tgattatcga gcgcttcttt cagctgtacg taaccgctgt 3769741 cataacggcg catgaagccg acttgaacaa ggcgtttgcc cactttgatt tcttcttcga 3769801 caatgcgcat gcatccttca gccgttgtcg cgagcggttt ttcacagaac acatatttct 3769861 gggctttaat cgctttcagc acgcttgact catgcgcagg cccccagctt gtcactaaaa 3769921 cagcgtctac attttcgtct gcaagcaagc tgtcatcatt cggataaacc gtcgcgttta 3769981 attggtattg ctcaacgacc ttttgtgcag cttcttgatt aacatccgtt acagctacaa 3770041 tttccgcgcc tgacagcttg ttcgtgatac ggttaatatg ttcttttccg attgctccag 3770101 ttccaattac gccaatacgt aaactcattg acagccactc cttctgttgg ttacatgatt 3770161 ttgctttctg ttcctttctt tacttggctc tgaggagacc cgtagagttc ctcttgaatt 3770221 tgttcaagcg acttgccaga cgtattcggc gcaaagagca gcccgatgat catactggcc 3770281 gtcacacatc cgagaagaat tgcagccatc gttccaatgc cgaaattggt gataatcatt 3770341 gggacaaaca gactccaaat ccctattgaa atacggacaa ggaaaaacat cagtccttgt 3770401 gcggaagcac gatattgcgt aggaaagatt tcgctggccc ataactgata gttcgcttgc 3770461 tgcccggctc cgttattgat gccgatcacg acaataaaca ggagcagaat cggcaggcct 3770521 tcaactggca gcagaaacag tgtccacccg atcaccgcca tgaaagcggc gattccaaat 3770581 acggtttttc tatatttgtc ggcaaagggc atgaagatca aggcgacccc caatcctgtg 3770641 aagataaaca gccccatttg caaaaggttg gccatgttgg cagatacacc gccgacctgc 3770701 tgataaatgt atggcataaa gaagcccatg accccggcgg ctaggttcca aaccaagtac 3770761 acacccatca aaaacaggat gctttttaga tacataggct tgagcaaatc aaaatacgat 3770821 gtcttattca atacagccgg cttctctgcc tgagcttcct ccggctgatt ttttgtctgc 3770881 caggcgtctg attccggaag cctgattctc aggatgtacg taatcagcgc aatcacaagc 3770941 agatgggcaa atacgatttt attccccaag agtcccaagt caccggccag tacggagagg 3771001 agcagtacaa cgacagcgcc cgcggcccaa gcgacttgtg ctacgccgca atgcctggcc 3771061 cgattcttct ttggcgcatt ttccgcaata atggtccatg acgcggttat gtcagcccct 3771121 actgataaac cgataatgat gtaaccgctt aacaacatgg ggaaattaac cccgaacaaa 3771181 accaaacaaa tccctagtgc ataaaccagc atactattgg tataaacagc cttccgtccg 3771241 actttatcag ccagaaaccc gccaagcagc gcgccgacag cggcagaaat cgcatttgcg 3771301 ctcaacgcgc cgagcagccc gatttgcgta tcggatagct taaggtaact gacccataat 3771361 gataaaccgg cggagcctgc cacaattgaa ccggcatcaa tatagttggc caatgctgcc 3771421 gcgattgtcc gtttattgaa ggctgaatct ccattggtat tgcccatatg ttcattcccc 3771481 attaagccag atccaacaac tgctgatcaa tatagtttct cgcaatcaat gcatactcca 3771541 gcgggtttgc aacatcgggg tcttgttcag cttcaatgac aatccatccg gaataactgt 3771601 gcttcaacag cagctgatat acttctctaa agtcaatgca gccgtcaccg ggaaccgtaa 3771661 acatgccttt taaaaatgat tgccggaacg attgtccttc gagcctgcat tgttccatga 3771721 cattcaggcg ggcatcctta aagtgcacat gcttaatgcg gccgatatgc ttctcaagca 3771781 tccccatgta atcgccgtca gaaatatacg catggcctgt atcatagagg aggtgtacat 3771841 gcgcagggtc tgttcctgcc atcaggcggt ccacttcttc cgctgtttgg acaccagtgc 3771901 cgagatgatg atgatagaca agcttcaagc catgctgagc ggcaatttcg ccaaggtgat 3771961 tcagcccttc gcaaagccgc tcccattcat catccgtaaa gtgcggcttc tctgtgaaca 3772021 catttttctc caagctttgc acgctgtacg tttgttcaga gacaactgcg acatccgcgt 3772081 ttacttgctg caaatactca caatgcaggg taaatgtctt tgccgcttca ccaagtccgt 3772141 cacgcaaaat aaaactgctg aaccattttc ctgcaatgcg taagttccga agcttcagct 3772201 ctttgttcag gatggcaggt tcggggaaaa agcccccgac ctccgtgcct tgaaaacgtg 3772261 cgacaacgat atcacttaac aaatgctgaa gtgtatttcc cgctccaatt tcaggcatgt 3772321 catcattccg ccacccaatg ggagcgattc cccacaggat ttcatttttg cccatctatg 3772381 gtgcctcccc tctaatactg cttcgcagat tccagctttt tctcttttgc ttcgtatgct 3772441 ttctgaacgc tttcttgttc agatacctct gccaccccga catgccacca gctgtcatag 3772501 ccgtccgtca ttgttttagg cagcaccttc atttcaatta atgttgatac atcctgtttc 3772561 ttcgcatcct ctaacgcagc ttttaattct tctactgtgt ttgcacggta ggttttcgcg 3772621 ccgtatccct cagcgacttt cgcgtaatcg acattcagga tttggttgtc atctgtgcgg 3772681 aactcgcaat agtagctgcc gctgccgtga tccatttgca ggttgttgat gcatccgaat 3772741 cctgagttgt caaagagcag cacattgatt ttcttgttgt actgaatcgc cgtgatcagt 3772801 tcagaatgaa gcatcaggaa gctgccgtct ccgacgattg aatacacttc tctgtcaggg 3772861 tgggccagtt taagaccgag tgtcccggac acttcatagc ccatgcaaga atatccatac 3772921 tccaggtgat acgtattcgg aacattagaa tgccacagac gctgcaaatc tcctgggagt 3772981 gagcctgctg aacagatgat gacgctgtct tcaggaatcg tctcgttgat tgtcagcaat 3773041 gccgttgttt gcggaagctc cgtattcaac gcgtcagcat attcattcag gacctcttga 3773101 gaaaagtgat ttttgatttc cggatcaaat gcttcccgct taaacgtcac tttgctgaga 3773161 cgctcgcgtt cagctagcca ttcgtccttc agctcccgga tcgttgtgcc gaactcgctc 3773221 tcatagcctt caagcaagcc gtgcagtttg ccaagcgtca ctttcgcatc cgccaccact 3773281 tggaatgcat caagtttata cgcctgcatt cggctgacgt taatgttcaa aaacttcgct 3773341 ttatcaaaat caaaagcggt cttagaggat gtcgcaaaat ctgtatacct tgtgccgatg 3773401 ccgataatca aatcagcttg gcgggccgct ttgtttgccg caagtgtacc tgtgatgccc 3773461 attccgccaa ggttgttcgc aaaatctgcc tcaacggtag actttcctgc ctgcgtttca 3773521 actaacggaa tgttataggc ttcagaaatg gcaaccaatt catcgcgcgc accggaatat 3773581 tttgcgcctc cgccgacgag aatcacaggt tttttgctgg atttaatcag ctccgccgca 3773641 ccttgaagct cgcgctcgct cggctgcatg cgatcaatat agtgaacccg tttgacgaag 3773701 aaactttcat caaaatcgta tgcttcccct tcaacatcct gagaaataca aatcgttgcc 3773761 ggacctgctt ttgccggatc agtcatgact tcaaacgcgc gcagcaaact gctcatcagc 3773821 tgctcagggc gcgtaatgcg gtcccagtat ctcgatacag gcttcaatgc atcgtttgtc 3773881 gtaatcgccg cactgtattc ttgctccatt tgctgcagta cagggtctgg ctgtcttgtc 3773941 gcaaatgtgt ctgccggaat caagagaact gggatattat ttgccaatgc agtgccggct 3774001 gccgccacca agttagccgc tccaggtccg acggatgtag acaccgcata tatttttctt 3774061 ctcagcattt gcttgctgta cgccatggcc gcatgcgcca ttccttgttc atttttccct 3774121 tgatagactt tcaaatggcc tgcatcctgc tcaagcgcct gcccgatccc taatacgttt 3774181 ccatgaccga aaatcgtgaa gatcccttcg acaaaaggct cttcctttcc atctacatgg 3774241 atgtactgct ggtttaagaa tttaatcagc gcctgcgcag ttgttaagcg aattttctta 3774301 cccacaaacg atcccacctt tactcgatct ttttcaatta tgactgtgct tcaataagct 3774361 gttcgatttc ttccgcagtc ggcatcgctt ctgacgaact gtgcttgctc accacaatgg 3774421 aggctgaagc actgccgtat ttcaatgccg tttcaatgtc ttttccgctg acaaggccat 3774481 agataaaggc tgacgcatag gagtcaccgg ccccaaaggt tttcagcact tttgtcttgt 3774541 acgcttgagc gcggaatacc tcgccggatt tgctgtatgc gtaagagcct tcgacgccgt 3774601 gtttgatgac aacgaggtcg gctgaatggc caaataaatg attgacggat tcttcattgc 3774661 ttccgcctgt gcggttttcc atcacatcaa attcatcgcg tgtgccgatg acgatatcag 3774721 actgctcggc aaccaaagaa taataaacgg ctgtttcatc tgatgactgc cacgtatatg 3774781 gccggtaatc cagttcgaat accaccttaa cctgatgctt tttcgcgtat tgaacagctt 3774841 ttaacaccgc ttcccgtgac gggcttttgg cgagcgctgt cccggagaca agcagcattt 3774901 tcgcatttgc gatatagtcc tcacttacct ctgaaggctc aagataaaga tccgccacat 3774961 catcgcgata cattaagatg ctgcattctt cagggctgag gatttctgta aatgcaaggc 3775021 ctgctttgtg tccatcttga tcaacaatca tctgtgtagt atccacgccg gtctttctca 3775081 tataggactc tatgaatctt ccatgctggt catccggaat tttgccgatg aagcccgctt 3775141 ttaagccaag cttcgcgctg ccgatcgcga tattcgcagg tgaaccgccg acatatttcg 3775201 aaaatgtcat cgtttcttcc attgggcggt tgtattcgac tgcgttcaga tcaatacatg 3775261 cccggccgat ggcaacaata tcaaaagcct tctcttcatt gaatgtatac ttcatcgtaa 3775321 acagccactc ctcacttgtt agcgttctaa aatccattca tgcgccgggt cgttataaaa 3775381 cttccatttt cgcgtcggcc ctgccatgac atttaaatag taggatgtgt atccgtccgg 3775441 aacgcctacc gggtggtatc ccgcaggaac gatgacaacg ttttcatttc ccacagtcat 3775501 tgtctcgtca atagaacggt catctgtgta tacgcgctga aacacaaagc cctgtcccgg 3775561 gtctaactca tggtagtacg tttcttctaa gaaagattct tccggcaagt tgtcttggtc 3775621 atgtttgtga ggcgggtagc tggaccagtt gccgctgtct gtatagactt caactactaa 3775681 tagactgtta gctgaagggt ctgaatccgg aagaatgtta tgaacagtac gtttgtttga 3775741 aaattgcccg cgatgctcaa ttccgttgtc ttccgctttg atcagctttg tcggaagctg 3775801 cttttccgat ggagaatagc aaagcgccac tcttgcgtcg ctgaccgctg tgatctcaaa 3775861 tgcacggtca tttgaaatat agacgctgtc tgtcggtttt cgttcaaata cgctttcgcg 3775921 cgtgccgata ttctcaaaag tcgactcatg atctgtcact gtaattttcc ccgttaccgc 3775981 cacaatacag atttcttgtt ttttcaattc ttctgtatag cttgaacctg atgcaagatc 3776041 taacacttta aactctacat aagtgagatc agagttggat gtcgttactt cgtgcacgag 3776101 tttgacccca ttagacactt catgcgactg cggcttacgc aacaaataac tcatagagaa 3776161 gccctcctct ttctattggc agaatgagtc cgaacagcgc acatggacgc cgttcggctg 3776221 ttcgtcgttt agttgaaatc aggtgccgga tatcttgccg tcaccacttt tttacgtgta 3776281 tagaagtcga cgctgtcttt tccgttcgca tgcagcgttc caaagaatga agatttccag 3776341 cctgagaatg ggaagaacgc cattggagcc ggcacaccaa ggttgatgcc tagcattccc 3776401 gcatcaatgt tttcacggaa gtagcggatt gcgtttgagt tggatgtgaa caagcaggcg 3776461 ccgttcgcaa actcagactt attggcgatt tcaatcgctt ctttcaggtt tttcacacgg 3776521 atgacagata agaccggagc gaaaatttca tctttccaga tcgtcatttc tgttgtgaca 3776581 ttgtcaaaga tcgtcgggcc gacaaagtag ccgtcgtcag acacattttc acgtccgtca 3776641 catacgagtc tggcaccttc ttcaagacct ttttcgatat agctgagcgt gcgcttcttg 3776701 ttgtcttcgc gaatcaccgg tcctaagaac acgccgtcat caaggccgtt accgatttta 3776761 atgtccgcca ctttttcctg cagcttcgcc ataaattcat cggcgattcc ttcttcaact 3776821 gtcacaaccg cacaagccat gcagcgttca ccggcagaac cgaaggcagc tccaacgatg 3776881 tttgtaaccg tgtcttcaag attcgcatcg ttcaagacaa tcgtatggtt tttcgcgcca 3776941 gtcagagatt gaacgcgttt taagttttcg cttccttttt tgtagacgta ttcgcctact 3777001 ggcttggagc ctacaaatga aatcgcttta atttcgggat gctcgaggat gccgttcaca 3777061 acgtcatgcg caccgtatac gacgttgaac acccctttcg gaaggcccgc tttttcaaaa 3777121 agctcaacca atttctctgt taacagcgga gtccgctcag atggctttaa aataaatgtg 3777181 ttgccgagcg cgatcgccat cgggaacatc cagcaaggaa ccatcatcgg gaagttgaat 3777241 ggcgcgattc cgccgacaac tccgattggg taacggtagt tcgccgcttc aacgtccgtt 3777301 gcgatggaag caagtgagtc acccatcatc agggaaggtg ctccagcggc gaactctacg 3777361 ttttcaatcc cgcgtcccac ttcacctaaa gcttctttcg tgttttttcc gttttcaatg 3777421 gtaattagat gagcaagttc ttctttatgc tgagacagca gctgctggaa gttaaataga 3777481 attctggcgc ggcgaggaac cgccaccttt gaccatgttt taaatgcttc agccgctgtt 3777541 tgcgctgcgt aatcaatatc ctcttttgta gaaatcggca cttggcatag cacttctttc 3777601 gtcgccggat tgacgacatc ttcatattga tctgttttgc tttcaaccca ttcaccgttg 3777661 atgtagtttt ttaattttct gatttctgcc attcttattg cctccttcat tagtaaacac 3777721 atacacttgt atggatggtt ccggatagat tcatatcaat atccactttt cagcaagcca 3777781 agaattaaac gctttcaaaa acaccaaaaa aataaatggc ggatgcatat ttacatacaa 3777841 gcaaccattt catgcacaac aggttacttt ttggtcattt cttggttata ttctaatcgc 3777901 ataataccca taagtcaatc ataaacacta cattttttca ttatttttat tatattaatc 3777961 ttttaatcaa gtaagagaag taagagaagg ccgtccaatc ttgcaaaaga tatacaccga 3778021 tgttatcatt tttaagcaac tattgattaa cttttggttt ttattatata tttatgttac 3778081 gtaaagattc aagaaggagt tttttatatg aaactgatgc ggattcagga aatggaggag 3778141 tacattttat cgcatggcac tgtttcctta gatgagctgt gccaggtgtt caatgtctcc 3778201 aaaaacacag tcagacgtga tatcaacaag ctaacagaaa agggtgcgat tgaaaaagta 3778261 tacggcggcg taacatctat tgaaaaaacc gcattagttc cttttgaaaa tcgcaccatt 3778321 cagcaccagg atgaaaaaac aaaaatcgcc cattatgctt cccgatttat tgaagatcac 3778381 gatttggtct tcattgattc aggaacgacg acaaagtcta ttcttgatac gcttgatcca 3778441 gccaaaaatg tcaccatctt aaccaacagt ttagacatta tcaatgcggc gtcagctttg 3778501 aagaatatca acttaatcat tatcggaaac aactataaga gaaaaacccg ctcctttgtc 3778561 ggcatggacg acccggctat gcttgataag tacaatatca acaaagcctt tatgtccgct 3778621 accggaacga cgctgactca cggattgacc aattcggatc tgctggagta tgaaattaaa 3778681 aagaggattt cagaaaaagc aaaagaagtg tatctattgg ctgaccattc taaattcgga 3778741 aaatcaacgc ttctgacgta tgcaccgttt gacaggctgc attgcattgt gacctctcag 3778801 ccattagacg acgagtacac gcagtactgc aatgagcatc aaatcggcat tcatctggcc 3778861 taacgtttac aatagtgttg agagtctatc atccatttta ttctaggagg cagatcatga 3778921 aaaaagcgaa gctcggaaaa tcagacttgc aggtattccc tatcggatta ggaacaaatg 3778981 ctgtcggagg acataacctc tacccgaacc taaatgaaga aaccggaaaa gaattggtgc 3779041 gcgaggcgat ccgtaatggc gtgacaatgt tagacaccgc ttacatttac gggatcggcc 3779101 gttccgaaga attaattggt gaagtgctgc gtgaattcaa ccgtgaagat gttgtcatcg 3779161 cgacaaaagc cgctcacaga aaacaaggca atgactttgt ctttgataat tcaccagatt 3779221 ttcttaaaaa atcagttgat gaaagcctga agcgcttgaa taccgattat attgatttgt 3779281 tctacattca cttccctgac gaacatacgc ctaaggatga agccgttaac gcgctgaatg 3779341 agatgaagaa agccggaaaa atccgttcca tcggtgtatc caacttctct ttagagcaat 3779401 tgaaagaagc aaacaaagac ggtttggtag atgtattgca aggcgaatac aacctgttaa 3779461 accgtgaagc ggaaaaaaca ttcttcccgt atacgaagga gcataatatt tcatttatcc 3779521 cttacttccc tctcgtatca ggtttattgg caggaaagta tacagaagat acaacgttcc 3779581 cagaaggcga cctgcgaaac gaacaggaac acttcaaggg tgagcgtttc aaagaaaata 3779641 tcagaaaggt caacaagctt gcgccgattg ccgaaaaaca caacgtggat atccctcaca 3779701 tcgtattggc ctggtattta gcaagaccgg aaattgatat tttaatccca ggagcaaaac 3779761 gtgccgatca gctgattgat aacatcaaaa cagctgacgt gacgctttct caagaggata 3779821 tttcatttat tgataagctg ttcgcataag aagaaaacag ccttctccaa tggagaaggc 3779881 tgtttttttg tgcgataaat tcctaaataa ctgattttga agcaaaacct tacaaaatga 3779941 gccataaatc cgataaaata aaggtagttt atctcagaaa gaaagtgatt gagaaagcaa 3780001 aagtatgaaa cgttcatatc atctagctca tatgaaataa agctgaccca gcttctttta 3780061 tttgctggtc agaatagcgg accgtttcga tggtctatgg aggaaacaga atgaaactta 3780121 aatatgtaaa agccttagtt gcagtaaccg ttgctttagg tgtactgctg ccatcaacga 3780181 tttctcatgc aaagagcttt agcggccgct catcatctag ttacagcagc cgaagttcaa 3780241 gctcatcata cagcggaagc tataaatcaa gcccgaaatc aagctacagc tcaggatcaa 3780301 gctcttctag caaaaaatcc aagacgtctg acgattcatc atcatcgatt tcgcttaaaa 3780361 agaagccttc ggaaaaggca agttcatcaa gctctaaaaa atcgtcaggc accttttccg 3780421 gcgctacatc aaaagtaacc ggaaagacat acagcggaaa aacgtctaaa gcctatgttg 3780481 gcggacgtta tgtttcagtc aatcattact atcacgcagg tttcgcgcca tcaggatggt 3780541 ttggatatta tagcggattt acaatgggta tgttcatgat cagcatgatg cacccatggg 3780601 gttacaccta tcatccagtc ggaggccccg gttatgtttc ttatggcgct tcacccattg 3780661 cctggatcgt tgatatcatc gctttgatta ttattttaat cattgtcatc gcattgattc 3780721 gcgcatttaa agcaccgaag acgtacagaa ggagatttta ggcaatgaga ttaatattaa 3780781 atgagcaaga aattgtagac ggaatttgcg tgtatatttc caatgaagaa gatatctacc 3780841 ctgaagacgt tgaagtaaaa gaactatcgt acaacaagcg tacagggttc ttcgctgaag 3780901 ctacatttgg cctgcaccac aagcagctta tgtcagatga catttcagaa ggcattattc 3780961 agttcttaga ggaataccac aacttcaatc cggacgttac cgtcgttgaa ttgcaatttg 3781021 ataagaaaaa aggcttctcc gccttggttt ttgtcaacga agcagaagaa taaaaatgtc 3781081 ttaatcaaac cttactccgc gcgggtaagg tttttttaat ggtttctctg agcataaagt 3781141 tatttcgttt ttcctaaact cagcggatct gtgatcatct cttttggcta taaagtttcc 3781201 gttttttcaa aacaaatgtt tcaaatgaga taggaaatgg gtactaatct attaactttg 3781261 ttacatattt ttagatactc attggctcaa caactgagga ggagacattt gtgaagaaag 3781321 acacaaggaa atatatgatc tactttttcg gcgctttagg gggactgcta tatggttacg 3781381 atacaggtgt tatctccgga gcactcctgt ttatcaataa cgatattcct ttaacgacat 3781441 tgacagaagg attggttgtc agcatgctgc tccttggcgc gattttcggt tctgccttga 3781501 gcggcacatg ctcagaccgc tggggcagga gaaaggttgt atttgtcctt tccatcattt 3781561 ttattatcgg tgcgctcgct tgcgcatttt ctcaaacaat cggcatgctg attgcatcta 3781621 gggtgatact cgggttggcc gtcggcggtt caacggcact tgtgcccgtg tatctttccg 3781681 aaatggcacc gacgaaaatt cgcgggacac tcggcacaat gaacaactta atgattgtca 3781741 ccgggatttt gctcgcctat atcgttaact acctgttcac accgtttgaa gcgtggcgct 3781801 ggatggtcgg tctggctgca gtgcctgccg tgcttctatt aatcggcatc gccttcatgc 3781861 cggaatcgcc aagatggctc gtgaagcgcg gcagcgaaga agaagcgaga cgcatcatga 3781921 acatcactca tgaccccaaa gacatcgaaa tggaattggc agagatgaag caaggggaag 3781981 cggagaaaaa agaaacgaca cttggcgtgc tgaaagccaa gtggattcgc cctatgcttc 3782041 tgattggcgt cggccttgcc attttccagc aggcagtcgg cattaacacg gtcatctact 3782101 acgcgccaac catttttacg aaggccggtc ttggcacatc agcttcggcg ctcggcacaa 3782161 tgggaatcgg catcctcaac gtcatcatgt gtatcactgc catgatctta attgaccgtg 3782221 tcggccgcaa aaaacttctg atctggggaa gtgtcggcat cacactgagc cttgctgctt 3782281 tatcaggcgt gctcctgaca ctggggcttt ccgcatcaac agcgtggatg acagtagtct 3782341 ttctcggtgt ctatatcgtc ttttaccagg cgacatgggg tccggtagtg tgggtgctca 3782401 tgcctgagct cttcccgtcc aaagcacgcg gagccgcgac agggttcacg actttggtgt 3782461 tatcggcggc taacctgatc gtgtcgcttg tcttcccgct gatgctaagc gcgatgggca 3782521 tcgcatgggt ctttatggtt ttctcagtca tttgtcttct ctcatttttc ttcgcgttct 3782581 acatggtacc ggaaaccaaa gggaaaagct tggaggaaat tgaagcaagc ctgaaaaaac 3782641 ggtttaaaaa gaagaaaagc acccaaaacc aagtgctgaa tgagcgtaca ttataaaaaa 3782701 aggaatcgtc tccttatgag acgattcctt tttctgttta caccatgacc ttgcaaatat 3782761 tgttcgtaaa ttccacaggg tcctgaatcg gcaggccttc gatgaggagc gcctgattgt 3782821 acagaaggtt tgtgtacagg ctcagcttct ctttatcttg ttcaaacgcg tcctgcagtg 3782881 tttggaatac ctcgtgattt gggttgattt ccagcacttt ttccgccttc acattttggc 3782941 tgtcaggcat cgcatttaag attttttcca tctcaattgt cacttcgccg tcagcagcaa 3783001 ggcagactgg atgtgattta agccgttttg agattctgac gtttttcact ttgtctgaca 3783061 gaatgttttt catttcctca aacagatcct tatacttgct ttcctcttcc tcggactgct 3783121 tttgatcctc atccgtgtct atgccaaggt ctccgcttga tacggacttg aattcttttt 3783181 cctgataaga agccagcatt ttaattgcaa actcatcgat gtcctcagta aagtagagga 3783241 tttcatagcc tttgtccgcc accatttccg tttgcggcag tttctcaatg cggtcgtaag 3783301 aatcaccggt cgcgtaataa atgaatttct gctcctctgg cattctggaa acatactcgt 3783361 ctaagctgac cagttttttc tcttttgaag agtagaataa gaggagatcc ttcaattgat 3783421 ccttattcgc gccaaaatca ttgtacacgc cgaatttcag ctgtctgccg aacgacttgt 3783481 agaacgtctc gtatttctcg cggtcttttt tcaacaggct ttgcagctcg cttttgattt 3783541 tcttgctgat gtttttcgcg atcagcttca gctggcggtc atgctgcagc atttctctgg 3783601 aaatattcag cgacagatcc tcagaatcga ccatgccctt cacaaagctg aagtggtccg 3783661 gtagcaggtc tgcgcactta ttcatgatca gcacgccatt ggaatacagc tccaagcctt 3783721 tctcatattc cttggaatag tagtcaaacg gcatgttttc agggacgaat agaatcgcgt 3783781 tgtagcgaac cgctccatcc acgctgatat gaacgtgtgt cagcggttta tcaaacccgt 3783841 aatgcttttc agcatagaat ttttcataat cctcatctgt cagctcgctt ttgttttttc 3783901 tccagatcgg caccatgctg ttgaccgtct gctcttcctg cacctcttca aattcatttt 3783961 cgctgccttc cttcggctta ttaatggttg tatccatttt gatcgggtag cgaatgaagt 3784021 cggagtactt cttgatgatc gcttttaaac gatattcctc taaaaactcg tcatagctgt 3784081 catcttctgt gttctctttg attttcagga taatgtctgt accgacagaa tccttttcac 3784141 acggctcaat cgtatagccg tctgcacccg cagactccca tttataagcc tcttcgctgc 3784201 caagcgcttt actgatgact gtcacgacat cggcaaccat aaatgccgcg taaaaaccga 3784261 caccgaactg cccgataatg tcatgtccgt ctttcagctc gttttccttt ttaaacgcga 3784321 gggaaccgct ttttgcaatt gttccaagat gctgttcaag ctcatccttt gtcattccga 3784381 tccccgtatc agagatggtt aatgttctcg catctttgtc agctgcgacc tttatgtagt 3784441 aactgtcttt atcaaacgta agcgcatcgt ccgtaagcgc tttgtaatag attttgtcaa 3784501 tcgcatcact cgaattggag attaactcgc gcaggaaaat ttctttttgg gtataaatgg 3784561 agttaatcat catatccagc aagcgtttag actctgcttt aaactctttt ttcgccactc 3784621 ttgatcgctc ctttaccatt atgtaaaccc ttttcagcat ctatttatca cataagatga 3784681 caattgtcaa ttagattgat agatgcatat atatgtaaat ttaacattag ttggatttgt 3784741 tttcactctt tttctcactc attctcataa aaaagagagg cttcatcatc ctctcttttt 3784801 ttctgtgtca ttccaacggc caaactcccg cttcatccat atatgcaccg ggtagaaaaa 3784861 caaaccgaac ggtatcaaaa acaaaagatt atgccatgaa gcattcagaa atgcgcttgc 3784921 agtcaccggg aacgtaatct cttgcaataa aaaagagatg acagtcagca caacaaatgc 3784981 agatggaatg gtcacgatgc aataaaactt gagctccttc ttatgctgta ccttcaaaca 3785041 tacaaacctc ccaacaattt ctaattcatc ttaacatatg ctggcctttc ttttctcgca 3785101 tgtttatcac tgcacatagc gggaagacaa atagaaaaag gaggtctcgt atcatgggaa 3785161 gacttgaaaa caaaacagca gttatcacag gcgccgcgac aggcattggt caagcgacgg 3785221 cggaggtttt tgccaatgaa ggcgcgcgtg tgatcatcgg agatatcaat aaagatcaaa 3785281 tggaagaaac agttgacgca atcagaaaaa acggaggaca ggccgaatcc tttcacctcg 3785341 atgtgtcaga tgaaaacagt gtgaaagcat ttgctgatca aatcaaggat gcatgcggaa 3785401 cgattgatat tctgtttaat aatgccggcg ttgatcagga aggcggaaag gtgcacgaat 3785461 atccggttga cctgtttgac cgcattatcg ccgtcgacct gcgcggcaca ttcctttgca 3785521 gcaaatattt gattccgctc atgctcgaaa atggaggctc catcatcaac acctcctcca 3785581 tgtcaggccg tgccgcggac cttgaccgct ccggctacaa cgccgcaaaa ggcggtatca 3785641 ccaacctgac aaaggcaatg gcaatcgact acgcacgaaa cggcatccgc gtcaattcca 3785701 tttcaccggg cacgatcgaa acaccgctga ttgacaaatt agcaggcaca aaagaacagg 3785761 aaatgggcga acaattccgc gaagccaaca aatggatcac gccgctcgga cgtcttggcc 3785821 agcccaaaga aatggcaaca gtggcactgt tcctcgcatc agacgacagc tcatacgtca 3785881 caggagaaga catcaccgca gacggcggca tcatggcgta cacatggcct gggaagatgc 3785941 tgattgagga gaaatggaag gaagaaacga aataagagag ggagccccct ctctttttgt 3786001 cttttaaagc aatacaacct tatatttctt cacatccaaa aactgcaaaa actccctcgc 3786061 cagcacttca ggcggatgcg cctttccttc atccagccga tacaaaagca acccgataat 3786121 cattgcggat acataatggg cataaagctt tttctctgcg tgaatatcag tttgctgatg 3786181 cagataaaac gattccagcg ctttgaacat atcaggtatc acatgaggaa caccccattc 3786241 ccgattgaga aaatggacaa tgggcatgtt tgacaaagca gaaagcagaa tggcgagcgc 3786301 cttctccgct tcctttaagg aaaattcatt cgggctggag gcaatcgtca ggtgatcaat 3786361 gatctccgca catgatcgct gtatcatggt ttggagcaat tcctccttat tggcatagtg 3786421 atcataaaag gttgcacggc ggatattgct tttacgcgta atatctgaaa tcgtgatgcc 3786481 cgcgtagtct tgtttctccg ccaatacatc cagaaatgcc ttctgcagcg cctctctcgt 3786541 tcgaaccacc cgcctgtcga tttgcttctc cttctctcgc tctcctggca cagcttttcc 3786601 aaacagccaa taaaaccgct tttgagaaac aagctcccat accttctggc tgatggcttc 3786661 aggagacgcg gccgcatcct cattcagcca atacaggata atcgcgtacg tgtacaaggc 3786721 ccgataatgt ccataaatgt cccgttcaat cggcgttaaa ttcacatgga tcggagccag 3786781 cagcacatcc tgctgaaaca catccttaaa aaaacgatga aaatgtcctc tgttcatcat 3786841 cacagaaaaa aaggaacgat gctcatgaac aaaggacagc gtcggatgca ccgtttgccg 3786901 ttttttgttc aaatgaaggg tatccatatg actgaaggcg tcaaaaagcg ctttgcccag 3786961 tccttccttc atgtcttcga tcacatcctc aatgattgaa aacttatcct cataataaag 3787021 gtagagcgat ccgcggctca ctttggcctt ctcagcgatt tctttcattg tgatgtgttg 3787081 aatatctcta tctttcaata aagccagcag cgcctctttc acttgagctt cggcagattc 3787141 cggcacaaaa gacacctcca atcattagac agatcttaga tatatgtacg gtaacgtata 3787201 gatggttcac cgttgtcttt cttacagaaa aggtaccacc ttataatagg tccgagaaaa 3787261 gaagaaagca aatgaggggg attttacaat ggaacagcaa gtaaaggacg acatccagcg 3787321 tgtctttcag cttcagaaaa aacagcaaaa agccttgcgc gcttcaacag cggaacagcg 3787381 gagagaaaag cttcaacgct ttttagattc cgtcatcgcc catgaagaag aaatcatcga 3787441 agcgatccgc aaagacgtcc gcaaaccata tcacgaagtc aaaaaagcgg aaatcgaagg 3787501 aacaaaaaaa gcgattagag ataatatgaa taacctggaa caatggatgg cgcctaaaga 3787561 agtcggttca tcgttaagcc ctgacgcaaa cggaattctt atgtacgagc ctaaaggcgt 3787621 cacactcatc ctcggcccgt ggaactatcc gtttatgctg acgatggcgc cgcttgccgc 3787681 ttctctcgca gccggaaaca gcgcgattgt gaagctgtcc gatttcacga tgaacacgag 3787741 caacattgct gctaaagtaa taagagacgc ttttgatgaa aaagaagtcg cgatttttga 3787801 aggagaggtt gaggtggcaa ccgaactact tgatcagccg ttcgaccata ttttcttcac 3787861 tggaagcaca aatgtcggga aaattgtcat gacagcggct gccaaacact tggcatctgt 3787921 cacacttgag cttggcggca agagcccgac gatcattgac agtgaatacg atctgatgga 3787981 cgcagcgaaa aagatcgccg tcgggaaatt cgtaaacgcc ggccaaacct gcatcgcacc 3788041 tgattacctg ttcattaaaa aagacgttca ggacaggttc gcggggattt tacaaacagt 3788101 cgtcaacgct ggatttatgg aggatgatca taccccagac cgcagcaaat ttacgcagat 3788161 cgtcaatgac cgcaacttca accgcgtcaa agatctgttc gacgatgcca tcgaaagagg 3788221 ggcggaagtg gtgttcggcg gcgtattcga tgccagcgac cgcacgatct cgccaaccgt 3788281 tttgaaaaac gtcacgcctg acatgaaaat catgcaggag gaaatcttcg catcgatcct 3788341 gccaatgatg aactatgaag acatcgacga ggtcatcgat tacgtaaatg accgcgataa 3788401 accgcttgca ctttatgtgt tcagcaaaaa ccaagatctg attgacaacg tccttcagca 3788461 cacgacatca ggaaatgccg ccatcaatga tgtcgtcgtc catttcagtg acgtcaacct 3788521 gccattcggc ggcgtcaaca caagcggaat cggctcctat catggggtat acggattcaa 3788581 agagttttct catgagaagg gtgtatttat tcaggccgct gaataatcgc atgatcaaaa 3788641 ggcgcttcct tagaggagcg ccttttattg taactccttg accaaaagca attcatcacg 3788701 gataggtatt ttattatctg ccagtaaagg aatttcgggc ttcatctttc tggccgtctc 3788761 gactgcattc acaaatagtc gatccaaccg gtaccctctc ttctgataaa acgctaatgc 3788821 atgaatatta tcattggttg tgatcagttt tatttgtttg atatttctct ctctgcatgc 3788881 ttcctcggct ttctctagca gagctgttcc gatcccttta ttctcaatga cactatccag 3788941 cgaaatgatt tcacaggcat cttcttcaaa tatgtatgta ataaggccaa caatctggtt 3789001 atcatcgttg agcattccat aaccatctaa ttcatcgcag ttataaatac cgctagaaat 3789061 aaccatttgc ggactgcccc agtgtttttg aaaaaacgcg gaaacaagat ctttaggtac 3789121 ctggcatgtc ggaataatat tcatattttc ctccttttag ctgaacaaaa ataagagaat 3789181 taacaaccta ttttatgtca ttaatcccct tatctagtat ttactagaac ttataacttg 3789241 tcaaaagctg tctgaatacc aattgcgtgg attgataagg atcaaaatct gaatcctgag 3789301 attggaagat ttgctctggg gtcaatgtct ctgcgttctc tgataacgtt tgaatcagac 3789361 tttccaaata tccatttaac tctgatttgg acgattcatg tagggattga tgatttacag 3789421 cgagttctct aaatctgtta tcactgatta atttttttcg aagagctgct agcatcaagt 3789481 caagccatgc aggctggcca aatgtaatat ttaaagctaa cgttgcttga tcagatttgg 3789541 tggagtgcca taaacctctt ggcaaataca gcatggttcc cggtgttaaa ttaacgattt 3789601 ctgcatctgg cagatcctct tttggcggat ctcctttcca atatgactgt aaatcatcag 3789661 gatagtaagg agcctctgat aaatcatagt gctgcattgg attgctcaca ttttcattct 3789721 tggcaagctt ccatgttttc tcaccttgaa tttgaaaaat caagttggtg taggcgtcaa 3789781 aatgggcttt gaatcccccg ccatttttcg ccgcgtaaac aatggctttg gaagaagtac 3789841 ccgcaggcag tcttaattcc gctttgagtt tttctatcca ccttctgact tggggaataa 3789901 ataggtcggt gaaatcaaac tctaatgcag cccctttttc ataccactct aaagcctctg 3789961 caggtgacac aagaaatctg tctgtgatcc cttcagattc ttcaatcaca gcatcaccaa 3790021 cgaccatgac tggattattg tagatagcca atacgttttc tagcgttcta accttttcaa 3790081 accccggtat gcttgtaaat ctctccactt ctcctctggc taccaaaggt tttacaggcc 3790141 aatattcttc taaaaactca ctcatcgtta caggactgat gatagactcc aaaaccgatt 3790201 cggttacagc actcatatta tccctcccaa aaaaagtaac ttcaccacaa agatataaca 3790261 tttttttcta aaagtaaata ttgacagaat tatcagagga ttataatatt tagttgtgcg 3790321 tgatagccta tttttttaca aggaaggagg gaaaaggatg aaaaaggctt ataagaaacc 3790381 tcgtcttttt gaactgcgcc gtgctgtagc agctggcggc cattaatctc atatagcatt 3790441 tgacatctag tactctattt taggagggat gctcaatgaa aaaagcttat aagaaacctc 3790501 gcctttttga actgcgccgt gctgtagcag ctggcggcca ttaatctcat atagcatttg 3790561 acatctagta ctctatttta ggagggatgc tcaatgaaaa aagcttataa gaaacctcgc 3790621 ctttttgaat tgcgccgcgc tgtagcagct ggcggtcatt aatcttatcc aaaacgatta 3790681 acgtttgagg ctatcacgcc aacttgataa ggaggatgct gaagatgatt acggctgaag 3790741 aatgcagaac gtacaaagaa tttgttgatc tttaccaatc ctatctttac cccttgcttg 3790801 gcgccagact gtcccggatg tattccccca aaaacaaagt cattatcgat atgggcacag 3790861 gtccaggtta tttaagcatt cagttggcta aaagaacaaa tgcgcacgtg catgctgtcg 3790921 atattaaccc ggccatgcat gaaatcgctc aagaagaagc taaaaaaagc ggagtaagca 3790981 gcctgatttc atttgatttg gaagatgtcc accatttatc ttacgctgac caatatgctg 3791041 acttcatcgt ctcctactct tgcctgcatc attgggaaga cgttgttaaa ggacttaaag 3791101 agtgctatag agttctggct ccgggcggaa aaattgtcat tttggataca tttaatcccc 3791161 aaggaagcca tttagagatt atgcgaaaac aaatcaaaga accggaatac ttcaggtttg 3791221 taagagaggc atttgaagaa agttattcct ttgaagacat tcaccagttt gttcaggatg 3791281 ccggcattcc caattattca ttagaaacct ttcacttttt accggaggat tttatagaaa 3791341 gcttagatga gctggaggat gctcccctgt gggaacaaaa tgatcaaagt actgatcatg 3791401 aaattgagtc tgtcacatgg atgttaacga tagaaaaaga aaaggaaggt gcattgtaat 3791461 gatcaatgaa tcaactgttt tatccaaaaa tccagaaatg ccatcaagaa aatatttgaa 3791521 aagcattatt atagagccgg gcatcacttt aaatgaaatg gcatcagata tttataacca 3791581 tatcgacggc aaggtcagca tacatgatat ttgctcaaaa atcgtcaatg aatatgatgt 3791641 tgattatcaa acctgcttag aagattgtat ggagctgttt gagttgctta ttgatcatga 3791701 agcaatcaaa gttaagcagg gggcatgaga attggaaaaa caaaaagtgc ttgctttacc 3791761 agacgatgta catgagctga gtacacaccg ttctaaatca atcgtaaatt acatcatcac 3791821 tctgcttgcc tttgccaaaa aacaaggatt gactcatcaa gatattgtaa gctggattca 3791881 cgagcaatat gaggaaagag gatattatga tgagtggaga cacattaaca gccaacaacc 3791941 agttggatca tttgtggaac tctttataaa aggaagacgt ttactttatg acaaaattga 3792001 attgtttgaa acagaagata aatatgtcgt aaatacccac acttggtatg aaaaagaacc 3792061 tagtgaggcc tttttttatt ttgaaattga tcccgaagaa ttttctgcgt acgcttccat 3792121 tctcgcaatc gaaaacgcaa aacgtctcgg aattaaaatc gatattgtaa aagaaacaga 3792181 tgtagagaca gcttatatct ataaacatca ataacgctat tgggagggag acatatgtgc 3792241 gggctcgcgg gtattataaa tctggctgct ccccgttctc aggaatgtac ctttcatata 3792301 ttgaaaggca tggcagatgc catcagctat aggggaccgg atgatgaaca atatcatatt 3792361 gattccaaag tcggctttgc atttcggcga ttgtccattc ttgaccttgt aaatggacag 3792421 cagccctttt taaatgagga tggatcaatc gtcgttatgg taaatggaga aatttataac 3792481 tataaagaac tgaaggcttc tttacacaat catatgttta aaacgacatc tgattgtgaa 3792541 gtaattgttc atttatatga agaaaaaggg attggatttg tagacgacat catcggaatg 3792601 ttttcaatag ccatttggga caaaaataaa aacaaagtat ttttagttcg tgaccgcttt 3792661 gggattaaac cgctttttta cacagagcta aaacacgagc ttatatttgc ctctgaaata 3792721 aaatccctat tttctcatcc tcactgtccc cgccaattta attggaaaga agcactctca 3792781 gacatttggc taagcgggga agcagccagt aatcataaag aaaccacttc cttttttgta 3792841 aacatccaaa atctcgatgc tggccattat ctcgaaatta atttgacaac aaatgaacga 3792901 aaaacagcaa gctattggtc tttacaggat attttgctca ggcaaggcta tcgtgagaat 3792961 ctccatcccg atgacctgat tgaaggatat agagaactgc tggcagattc agtccataga 3793021 tgtttacaaa gcgacgttga agtcgggttg tttcttagcg gtggcattga ttcagctgca 3793081 gtcgcacatt ttgctgcaga aaaacaggat ctccatacgt ttacagtatt aagccaaagt 3793141 acatttacaa atgaagatgc aaaatatgcc cattggctgg ctaaagattt acaccttcca 3793201 aatcatcagg ttctctatca attagggaac gatgagttat tacaaccaga gtcatataaa 3793261 catttgttat ggatctgtga aacaccgttt tgcggaccgg aacaattata taagtttcat 3793321 ttacataagt atgccaaagc gataaggcca aacctgaaag tcatgctgac cggccagggc 3793381 agcgacgaat ttaacggcgg ttacagcacg acactttcac cagccgagaa cccaagttgg 3793441 gaaggattta ttgaatcggt caatacgatg gagatgaacc ggctgcatcg gctgcaggga 3793501 aatatcttta gagtgtggga ggagcatttt ggactttctc ctataaacct ttcttattta 3793561 aagagcaatg attccagcca agcagatcct tggcaatcgt atgtcctgac aaaataccgt 3793621 gatctgcaaa tgtataattg ctggcatgaa gatcggatcg ccgcggctaa tcatatcgaa 3793681 aaccgtgtac cgttcttgga ccatcggctt gttgaatggg tttgcggaat acctgatgga 3793741 ctccgtaaag acttgttatg ggataagtcg gtattgcgaa aatcattaac aaatgagctg 3793801 catacaagct atacccaccg gccaaaggtt ccttttttct atggtaagga cgtgagatat 3793861 acacataaaa tgatgtttca tcttctgaag aaaaacaatt atcagcttat agaggaggcc 3793921 ttctctcaca gcgatgcctc cagcataata caggttgaac acattcatgc catcatgaca 3793981 tatttggagg atgatcctga gtttacaaat tttgaatttt tattaagact ggtgaacatg 3794041 ggacttttat caaaaatgac taaagaaacc ccttctgttc aattagacat aaccagccat 3794101 ttagaatcga taacaataaa agactggcac tcacaggaag gtgatattgc cagtcgttta 3794161 aatatctcag ccaataagtg tgaaggacaa gatattttgg cgctaaaccc tggcgtcact 3794221 ctgttaaggc cggaaagcga tagtgagcat tgcatctaca ttgcggaaga aggatttatt 3794281 cagtttattg tttcggagga agacgtcgga gcttggctgc atattctctg cgatattaat 3794341 ggaaaagaca cacttcatac gattttagac agacatggtg tcagccttga agaagtggcc 3794401 aaatatattc aagaagccat cgaacacaat atcattttga tcaaacaaaa aaatctgcca 3794461 gaaggagcat atagatgagc atcttttatt cgttttccgc acttagggga ttagcaatgg 3794521 ggattttttc gcctatttgg attctttatc tgatatctaa agattatgat ttccttcaga 3794581 ttggattaat gggagcggta cttgaaattg ctaagcttat atttgaagtt ccttccggcg 3794641 tttttgctga tcgttatgga attaaaattt caattgccag ttcattcttt ttctccatcc 3794701 ttacatgggc cttcttccct tttatcgatt cagctgctat ttgcatactg gctatgatca 3794761 tatgggcttt atcagattcc ttaatttccg gttcttttga aacttggatg agccgtgtcg 3794821 caggggaaga tcgattcggc aaagaaatga tgaaaaacac acaattgcta atcacttttt 3794881 taattattgg aagtattgcc agcgggtatt tgtattcatt aaatatctat tttcctttcc 3794941 tgctcgttat ggtgatctac ttattactat ttatttggat gtctgtattt attaaagtcc 3795001 cttctgtttc cgaaacaaat catggggatc agaaccaaca tgattcgata aagattatca 3795061 aagaaagttt aaaaattatc tttaacaaaa aaagggttct tttaatcgtc atagccggtt 3795121 tctttacagc cacagcctat gacacaattt cccgttactg gcagcctttt ttgagtgatt 3795181 taggcttttc agaaaagtca ctgggatata tttttgccct aggagggttt accgctctcg 3795241 ttcttttgac attaaccatc aggttcgaaa agaagatcga aaaaaatcca tatctcgctt 3795301 taacctcatt ggattccatg ggcatggtca tgacttttct attgtctaga gcattcaggc 3795361 cgctgggcat tccatgtaca gcgtttttgc ttgcaattga agatattcat catccgatcg 3795421 taacaagtta cttaaataag tttttccccg attcatacaa gaacacactt ttctcgttaa 3795481 actcaggggt aggagcaatt ggagaaattc tttccggtgt cattttcggc atcatttccg 3795541 cagcctttgg gctctctgcc atgtttgttg ttgtagctgt atttctatta atccctatta 3795601 tcctttatac gatagtgcct aagattaaag acaatgatat gaaagttcag attgaaaaat 3795661 cccagcaagt gtaaatgttt tgtatcacag taagaagacc ttcttattaa aagaaggtct 3795721 tctgctattc tattcagtta tttcccaaaa gccatcagct tcgtataact tccaatataa 3795781 agtgttccgt cctcagcgag ctgaggagaa gacacgacgt tgctgtcggt ttgatagctc 3795841 cataattcat tgccgtttgc gtctgccgca taaaccttca tatcatctga cccgaaataa 3795901 accgttccct tcgcgtcaat cagcggcgcc gttctgacag ggccgtctgt gtagaatgac 3795961 cagttcatat ccccgttttt gctgatggaa aacagctcgc cgcttcctga gccgatgtag 3796021 atattgccat tatgatcaat cgcaggagat gagctggaga acccgtttag cgggaatgtc 3796081 catttcaaac tgcctgttga tgtataagca tacagctgtc catcttggtt gccggcataa 3796141 atgtttccgt ccttatcaat caccggatat cctttaaacg catttgacgt cgttctggac 3796201 catttcacct gtccggttcc ggagttgatc gcataaaaca cgtaattata tgtgccgaca 3796261 tacacggtgc cgtttttggc aagcaccggc acagagctga cgaccccatt tgttttcaac 3796321 ttccagcgct ctgtccaggt tgattttgac gtcggtttga tcgcgtgaac ataattatca 3796381 agtgttgaga aatacaacgt cccgtctgaa ccgatcaccg tttcagagct tggcccgccg 3796441 cttaacggaa ccgttgttaa aatttctccc gtttctttgt caataaaata aatctttttg 3796501 tcataggatg ccaaatagat aacgccgttg gtcccaagta caggagattg cgtatatgtt 3796561 tttccaagat tgcccgtcac ccatttgact gagccgtctg gattaaaggc tttcatttcc 3796621 ccgtctctgg aatgaagata tactgtgccg tctccgtcaa tcacagcccc cgctccattt 3796681 tgcggagtcg ttctgatgtc gttttgccat ttcagcgtcc cgtctgtatt tccggcgaac 3796741 cggctttcgc gtgaccagtt aaacatggca ggcgccatcg cttgtacatc atatcttcct 3796801 ggcaaaaagc cagatgctcc attattttga gaaaacaccg tttccgccgc ataagcagct 3796861 gtcggctgaa gcactttggc agcgggcaca tcagaaacag cgccggccga aacagccgcc 3796921 gccaccgcag ctcccgcaat caaagctttc atacgaaatg acttgaccat cattgagacc 3796981 cccattatat gtaacttcta atttgtgacc atcataacat attcatccat tttataaatc 3797041 tatttcacaa aaacatcaca aactagaaaa ctatgtaaga gtattcacgg acgttttttc 3797101 agcacccgat cgaaatgcag ccacaaacca aatgacgttg acagcagccg cagcgagact 3797161 aactcccaaa acaaagatca cctcagaaag cagatggtca ctaaagaaac taaacatcaa 3797221 gataaaaccg gccgaagaca aatgaatcaa aagcccgaag ccgcaaagca ccgccatgac 3797281 atacctcatt gcatcgactc cgagcatata aacgagaaat ggaatgaaat acaagacaag 3797341 gatcataccg acagctgacc acatgccagc tgaattaaac tgattggccg ccgctcccgt 3797401 tccggccagc ggcgaaagtg aagccgccac aatcacggcg caaaaaagaa acgcagaaat 3797461 ggttgtcatg atcgccacgc tatttttttt tgacatcaaa ctcctccttt aatagaaata 3797521 ttaacctttt ttattataag taagttgaat gttatattca ttatattttt aaaaaattcc 3797581 agaatacata cacaaatgct atgcttcttt ctagtatatt tatatagtaa aaaacaaagg 3797641 ataaaagact catttttctg taatatcagg attttatcac cataccatat tgcatgtaca 3797701 tgtttttcaa agtatactat tccagattaa ttcagaggag agagaaaaat acatggaaaa 3797761 accagcagga ttttggattc gttttttagc ttattttatt gacggcatta ttgtatctgt 3797821 tcctagttat attattctat ttattatcaa ttctgtgttt gtagctgggg ctgtggcaac 3797881 aaacccttac atgacggaag aagagtattt agtgaaatac atgacgcttg catttttgcc 3797941 tactatgctg atcatgatcg tcatcagcgt gttatattac gggctgctca cagcttctaa 3798001 aatgcaaggc acacttggca aaaaaattct tggcctgaaa gtggtcaatg aacaaggtga 3798061 acgggtttct gtcggacagg gaattggccg ttactttgcc tatatcttat ctggaatcat 3798121 cttttatatc gggtttatca tgatcgcctt tggagagaaa aaaggcctgc atgacatcat 3798181 ttgcaaaaca cgtgtcgtgt ataaataata gaaaaaagtc tagacgccaa taggcatcta 3798241 gacttttgtt ttctttgcaa taggctgcca cgacagatac gtagcgcttc tccacaacca 3798301 ctcaaacggc cccatccgaa agacacgaag ccaaaggtgg ctgaagacca tttgaacggc 3798361 acaaacagca attgtaatga gcacaccggc agcagggtac acttttccat acaggcccaa 3798421 gccgtaatga taaaaaatcc aagtacacac aatagactgc atcaaataat tggtaaatgc 3798481 catcctccca acagcggaga atgattgcag cactgttctc actcttgttt tatgataaag 3798541 atagacaacc gttgtaacat agaaaaacat gaggaaaggc gcgccaatca gcaaacatat 3798601 ttctttatcc gttacactgt acagcacctg ggcgccgatg ccgatgacaa gcccagccat 3798661 ccataatcgt tttaatcctt tgcgatgctt ttccggttca tgcaaatacc gtgattttgc 3798721 tgccgcagct cccagcaaaa acatgctgaa atatggaatg gatgcaaaga agtagttgag 3798781 cggattatac gtaagcatgc cattcgaaga catgtaaaca agacggtcgt ggatccgctg 3798841 ttctgcaata tccttcaggc tgccgcttcc ataaacatga atcgcttgtt ttgcctgctg 3798901 tgttaccgct tgtacccatt cctgtccgtt tgattgatca aaacttgtca acatgaacgg 3798961 aatggaaaac agaagataca aagagaccgc ccatatcagc agtgttttcg gctttgcttt 3799021 tcgaaacaag agcaggacaa atccgagcag ggcatattct gttaaaatat ccccgtccca 3799081 tatcaaaaag gcatgaatcg ttccaaacaa gagaagcgcc attaaccttc tcacatataa 3799141 cggaacaaac cgtttccctt tgttttctgc tctctccatc atgacaacca tgccaaatcc 3799201 aaataaaaag gaaaacaata aaatacattt tgtttgaatg aagaatttca gtatgtctgc 3799261 ggcggcaaaa tcagcttcag accacttatc catgaaaaaa ttctcttttc caagcataga 3799321 caaatacata tccggataac tgaaatgtgc cagattgaca aataagatgc cgaaaatcgc 3799381 cattcctctc agcacatcaa gcacaccgat ccgctcattt gttaaagtcg gctgtaatga 3799441 agacatagcc atcacgctcc ttttttctgt accttaaggg taggaaaaaa tgaagcgcgg 3799501 taacatcgat ttaggtgtca ggccggcatg aaaaccttac aatcttgtca tctttatggt 3799561 ttcatcacct ttaaatctaa tgcttcgata ttctgcaaaa tgcgatcaaa gcgcaaagcc 3799621 tgaggctcac atgggaagat gtggccttca tacgggtcgc ctaacgtccg gaaaaacggt 3799681 tcaaataaac caggaaccaa tacgcccacc atctttgtat agtgagaatc aaggcgatag 3799741 gagtgaacgg tatttgcagg gacatgcagg aaatctcccg gattcagctg aatttcctgg 3799801 ccatctgtcc acatcgtcat ctggccttca aggcaataaa atgtttctgt atgatattca 3799861 tggtagtgat caacgattcg gtcaccttta gggccttcag atgatacgac gataaactgg 3799921 ccatctgtat ttttttgtgc agccacaatg cggtgaagct gatctccagt caacagacga 3799981 tctccttctc cagattcaag aacgtatgga accgctccat ctggcagctc tgtaagttcc 3800041 gctaatttgg ccgaacatgc aggctttgct tcatctagaa atacaatgtc cgctacagcg 3800101 gctgcttctg caaatcgctc gtttgagact tcttcgcttg cgtacggcgg atgttcagcg 3800161 tgatcatacg gattcccaat aacggaatac aagtgcgcta cgtttccttt catcgtgtaa 3800221 gacaccagtc ttgttctgtg gctctgcatc cggtagctgt gcggtgttcc cgccggaatg 3800281 ttggcataat cacctgatat taataaatag cgttcaccat caagtgtcag ttccagtttc 3800341 ccgtccaaaa cgagaattcc ttcatgtgtg tccttgtgga cgtgaagcgg aaaggcatct 3800401 ccttttcccc cggaaagaag cacgatctca aacaaatcac ctgtgctcct cccattcgcc 3800461 atcaccgtgg caacctgtct gccgaacaga tagcgctcgc cttctccgct ccggagcaaa 3800521 taaggcattt tttctttagg caatgaatgt gtacataatg ttttcatatt atcgcttcct 3800581 ccaatttaga ccagtctata tattatcatt catttgtcta gaccgttcta tataattgta 3800641 ggagaaagga taacaaaatg ctaccctttt tttctcacca gcactggtat ttgttcggca 3800701 atgagaagaa gaggcgtttt gtctttattc gttaacgaaa gcatgatgcc gccctcaatc 3800761 atcgaattaa tcagcgttcc aagctgattt gcttcttctt ctgcaaatcc gttttccatt 3800821 aattttctgg caaaaaccgc ttcccagctt ttaaacacct tcatgcaaac cgtccgcagc 3800881 ggttcactga ttaacgctgt ctcactcgcc agcaaaccga ctggaatacc tttaatgctt 3800941 tctgtgttgt caaattggct ggctgttttt ttgataaaaa gctgaatcgc ttcaacagga 3801001 tcagaggatt catccatgct ttgctgtatc agatgttcaa cgatcttacc tgtatatgta 3801061 accgcttcaa ttgctagttc ttctttgcca ttcggaaaaa agtgataaag cgatcctttt 3801121 ggagcaccgc tttcttttac aatctggttc aaacctgtcg cgtgatatcc ttgcagctgg 3801181 aacagacgtg acgccgtgtg aaggattttt tcacgtgaat ctcctctgct agtcattaaa 3801241 acattccctc ctaggtatgg tagagcgact tatataatat aaaaaagaac cctgtgattg 3801301 tcaaaagggg taagaccctt ccggatgggg taatgtacaa aaacagcgtc taggagggat 3801361 ctctcaatga caatcgatca ttcagtcaca aatacagagc agcttgaaca acagaacccc 3801421 gccataaaaa caaagctcaa actgaaaaag cttaaggatc aggtgatcgt cattaccggc 3801481 gcttcaagcg gtatcggact tgtcacggcg agaatggcag ctgaaaaagg cgcaaaggtc 3801541 gtggcagcag cgcgaaatga agaggcgctg aaggagctca ctgatgaact taaggaaaaa 3801601 gggcacgacg ccatatgggt aaaggcggat gtcggaaaag aagaggacgt caaccgcatc 3801661 gcagaaaccg cgatcagcac attcggccgc tttgatacat gggtcaacaa tgcggccgtc 3801721 tcgactttcg gacacgccat ggacgtcacc gtcgaagaca tgaagcgcat gttcgacaca 3801781 aatttctggg gacctgttta cggaacaaga gcggctgtca aacactacac cggcagaggt 3801841 gtgccgggcg cactcattaa tgtaggaagc ctgttcggag acaggggaac ggtcattcaa 3801901 tccacatatg catctgccaa atttgcgctt cacggctgga cggaaagcat ccgaatggag 3801961 cttgaaaagg aacaggcgcc cgtctcggta acgctcatcc acccgggcag aattgacaca 3802021 ccatataacg agcatgcgca cagctacctc gacaaacagc cggctcatta ccgctccatg 3802081 atctatccgc cggaagcggt cgccgaagcg atcctgtttg ccgccgaaca ccctaagcgc 3802141 gacatgtaca tcggctcaca ggccaaagcc atcgccatgc tgggcgcgct ttttcctcgt 3802201 ctgaccgaca gactgatgga aaaaatcatg tatcacagcc agcatgccga aagaccgtcc 3802261 aatccgagag aagaaagcgc tctttatgat gctggctgcg gtatgcatga cagaggcaca 3802321 aataaaggat ggatgaggtc aagaagctac tacacaaaag cgacgaagcg cccaattgta 3802381 tcggcggctg ttgttgccgg actagtggct tgggctgccg ccaaacgatg cagataatct 3802441 ctgaccataa gaaaaaccca tgctgttcca gcgaaccatg ggtttttcag ctgttaatcg 3802501 ataaaagcct tgttcatacg ctgcagcagc tcgccgaaca tctctttttc ctgtgttgac 3802561 cattctttca gcatctgttc ataacgttca aggcgctttt gctgatcggc ttttaatagt 3802621 tgtttgccga gttttgtaat ggtaaacagg ctgactctcc catcagacgg gtctgagaaa 3802681 cgatagatga gctcctttgc ctctaatgca gctgcttgtc ttgaaagagt agaaatatca 3802741 agcttaaacg attcagccaa ttccttaaca cgagcaggcc caaactcatc caattgtctc 3802801 agtaataagt acgaagatct ctccaaattc cctgttcttt tctccgattg atccagataa 3802861 acagctctcc tgataaaagt cgtcagctca tattcaatta attcaactgg attttgattt 3802921 tgcaatcgct ctcgctccct attccaatct ccggcattga caacatcata tatacttgta 3802981 taatacaaat gtacattaac tgaataaata caagtcgtta tatgactaaa tcaattatta 3803041 tacttgtata gtacaatcat ataaaaagaa agtaaagcga ttcctcagaa ccatcctaga 3803101 agcaagcacc agaaaggagg aagctgttct gattggagag cagcacttga tgtgaaagtc 3803161 atacgaatta ttttgcaagt gttgatatta tatgtatttt ttatgatcgg ggaagccatt 3803221 cagcatctgt ttcatttacc cgtgtcagga agcatcgttg gattggtatt gcttctgatc 3803281 tgcttgggcc tccgtattgt tcccgtctcc atcattgaag acggagcagg gtttttatta 3803341 tccttccttc cattgttgtt catcccggca atgacaggag tgataaacta tccgtctctc 3803401 atttcattca atggcctgat gctgctgatt acagtcgttc tcagcaccat cgtcacgatc 3803461 attgcggctg gattcgccag ccagctatta gagaaaaaag caaaaaaacg ggaggagaaa 3803521 gagaaatgca gcaagcatgt atcgcgatca ttataattct tttaacagtt gccgcttatt 3803581 tagcgatggt caaactctat aagcgattcc cgcttccatt tctgatccct gttctgacaa 3803641 cgacaatttt gattgtagcg gctttgatga tgtttcatgt ttcctatgaa ggctatatga 3803701 tcggggggaa atggatcaat tctttgcttg ggccggctgt tgtggcgctg gcctatccgc 3803761 tttataagca atggcatatc attgtcaaac attgtgttcc cattttaggc ggcgtcctgg 3803821 tcggcttatg catgggaatg atcagcgggc tgatcttcgc agaagcattc gggattgatc 3803881 atgatctctt attatccatt ctgccaaaat cgatcacaac ccctgtcgct attcagatcg 3803941 ccgccggtct tggcggcgtc ccttccatga cagtcgtatt tgtcatgatt gcgggctttt 3804001 caggcgtcat cctcgggccg cttttcctaa aatggcttcg catacgcagc tccctaggac 3804061 aaggcattgc attaggcagc gcctcccatg cactgggtac ctccaaagcg ttggaatatg 3804121 gggaattggc cgtatccatg agttccgtct ccatgacgct ttgtgcggtg ctcggctcat 3804181 tcttcggccc gctcgtcgtc tggctgtttc atatttaaca aagaaagact gccccggggg 3804241 agggcagtct ttttcgttta agaagcaaaa aaatcaatca acggctgaaa gtccttagat 3804301 aaatcaacgt cattcggttc tgcttgaagc aggcggtcaa tcatacgctc cagctcctca 3804361 acatcattct tatccgtata ttcaatgaag tttaagcttt caagccaatc ccgatatgaa 3804421 tgtttggctt tgccatagct gtttccaaag acaaggcaag gtgttttggt gataatcgag 3804481 aaaatcatcg cgtgaaggcg gtcggtaatc accaatttac tggagccgat gcggtccagc 3804541 atctccataa aatgcttttc acgatcagcg taatcgatgg tgtctaccgt atccagcacc 3804601 gtatcggtac gctctgtgta agttgttttt tctgcccatt gcttcatctg tgaaataaaa 3804661 tcttcgtcag tcactttctc cttatccgct cttaaaataa agagaacgcc gtcccgctcg 3804721 agctctcgcg gcacaatatc caaggaaagc accatgtccg gtgtaaagat cacattggag 3804781 ttgaaggtct ctttcacaac atccagtgtt tgcgtctcac gcgcagcaat cgttaagttt 3804841 gtattttgat ggtacgcatc ctgtgttttt ttcttttcct tctgtccttc ctctgtatcc 3804901 tcaaaataaa cggattgtgg cagagaaatt gatttgtagt ctttaaacgc cgaaaagacc 3804961 tttcttctgt cttcctcaat atcgagataa aggtttccta aattccctcc gcctgtaaag 3805021 cagacaatat cgtcttcacg aatgatctcc ttcaccagtt caatgccctc atccgtcgca 3805081 taatccataa tctcaatgta ttcataatac ggaaaatgat ttttgataaa tttctcttcc 3805141 gcatacgcaa tcgcttggtc gccaatgttt gtgtagctag gggaaccaaa caaaaatact 3805201 tttcgtttat catttaacag agcttccggc tccacatttg gcgcaatgcc ttttactagt 3805261 tttttgcctt tgatttcttg tacagtcata tctgcgtcct ccttctggga tgaattcctc 3805321 attgtgtgtt aactgtctct acccaaaaag aaggatggct atgcattggc atgtgcatcg 3805381 gctatatcag aaacatcgtt ttcgccaatt tgatagacgc tgcaatgtcc cgcgccgttc 3805441 tttccatata ttccgcggca tgttcaaacg cgtcttctag tggcacggct ccggggacga 3805501 tgctgaaaag cgcatcgatt ccgtgttgat agacggcatt actgtctcgg gaaattgatc 3805561 ccgcaatgcc gataacgggc acatcgtatg atttagcggc cttggccacc ccgatcggtg 3805621 tttttccatg aaccgtttgg ctgtcgattc gtccctcgcc ggtaatcaca aggtctgcat 3805681 cctgaacgat actttcaaaa tcaaccgctt caaggacaat atcaatgcct cttttcaggt 3805741 cagcctgaag ataagttagc aggctccatc caagaccgcc cgctgcaccg gcgccctctg 3805801 tatctcggaa ggttgatccg agcgcttttt ctgccatatc agcgaaatgg cttacgttct 3805861 ggtctagtac atccaacatg tcggccgtcg cgcctttttg cggcccgaaa acagccgtag 3805921 caccctttgg tcctgttaac ggattgtcca cgtcacaggc aacttccagt ttgacattcc 3805981 gcaatctgga atcaagcccg ctcacatcta ttgatgcaag ctgagataac gcgccgcccc 3806041 ctgggccaat ctcgctgcct gagttatcaa gaagccttcc gcccaatgcc tgaatcatcc 3806101 cggctccccc gtcgttcgtg gcgcttccgc cgattccgat gatcaatcgc tccgctcccg 3806161 catcaagagc tgctccgatt aattctcccg ttccccttgt tgtagtgatg agcggatttc 3806221 gcttatctac aggcaccaga tgcagccctg aagcagcagc catttcaatc acagctgttc 3806281 tcccatctcc catcatgcca aagaaagctc tcaccggttc ccccagcggc cctgtgacaa 3806341 cttgctctat gatccttcca ttggtcgcat cgaccagaga ttgaacggtt ccctcgccgc 3806401 catccgccac cggcaatttt ctgtaatcag cacccggaaa gaccgatttg aaacctcttt 3806461 ctatcgcttc ggctgcctcc agagctgata agctttcctt aaaagaatca ggtgcaatga 3806521 tgattttcat ccaaatcgcc tctttcaaaa catgattcac ttaacctatt gatctccaat 3806581 gtaccataat tgatctggaa atacatacca tgcaatatgg taaaaattta aataaaaatt 3806641 agaaatgaaa gtgtttgcat aaaagaaata ttcacgttat catacttgta tacaagtata 3806701 ctccttgagt gaggaaggtg agtgtatgct agactccaaa gacctgttgt atcccgcaaa 3806761 atggctctca aaagcgtcaa ccggagttcg tgtcgcatac gagctgagaa tgcggatcgt 3806821 ttcaggtctg attgaaagcg gtaccatttt atcagaaaat acaatcgccg ccgagttttc 3806881 agtaagccgt tcgccggttc gcgaagcgct aaaaatactc gcatccgaaa aaatcatccg 3806941 cttagaacga atgggagcgg tcgtaattgg tttaactgag aagaaaatcg cggaaattta 3807001 tgatgtgcgg ttactattag aaacatttgt ctttgaacgg cttgtcaaaa tagacattga 3807061 gcctttagtt aaggatctca gcaaaattct tgaaatgatg aaagtctcaa tcaaatatga 3807121 ggatgctgac gaattttcat ttcaagatgt gctgttccat gaaacgatta tccgagcgat 3807181 tgatcattca tacattcaga tgatctggaa caatctaaaa cccgtcatgg aaagctttat 3807241 tcttttatcg atgcgggtac ggttaaagga aaagtatgaa gacttcacaa ggattttaga 3807301 taaccacgag ctttatattc aagccatcaa aacaaaggat agggcgctga tgattcagtc 3807361 tcttcaccaa aactttgatg atgtgcagga taaggtagaa gacctatggc tctcacaaca 3807421 aatgctggca aaaggagctg aatacaacaa tgactagtta tatgttagga atcgatatcg 3807481 gcacgacaag cacaaaagct gtgctgttca gtgaaaacgg agatgtggta cagaaagaaa 3807541 gcatcggcta cccgctctat acaccggaca tctcaacagc tgaacaaaat ccggaagaga 3807601 tttttcaggc agtcatccat acaacagcga gaattacaaa acagcatccc gaaaaacgga 3807661 tctctttcat ttcgttcagc agcgccatgc acagcgtcat tgcaatcgac gaaaatgaca 3807721 agccgctgac gccatgcatt acatgggccg acaacagaag tgaaggctgg gcgcataaga 3807781 tcaaagagga attgaacgga catgaggtgt acaaacggac gggaacaccg attcatccga 3807841 tggcaccgtt aagtaaaatt gcctggatca cgaatgaaag aaaagaaatc gcttccaagg 3807901 caaaaaaata tatcggcatc aaagaataca tttttaaaca gctgttcaat gagtatgtca 3807961 tcgattactc attggcatca gcgacaggca tgatgaacct gaagggcttg gattgggacg 3808021 aagaggcact gcgcatcgca ggcatcacgc cggatcactt atccaaactc gtgccgacaa 3808081 ccgagatctt tcagcactgc agcccggaaa tagcgatcca aatgggaatc gatccggaaa 3808141 cgccttttgt catcggcgcc agcgacggcg tgctgtccaa cctcggcgtc aacgccatta 3808201 aaaagggtga aatcgccgtc accatcggta caagcggtgc cattcggacg attattgaca 3808261 agccgcaaac cgatgaaaaa gggagaattt tttgctatgc cttgacggac aagcattggg 3808321 ttattggggg acctgtgaac aatgggggca tcgtccttcg ctggatcaga gacgagtttg 3808381 cctcctccga aatcgaaaca gcgacacggc tgggcattga tccatatgac gtgctgacga 3808441 aaattgccca acgcgtcaga cccggttctg acggtctgct gttccaccca tatctcgccg 3808501 gagaacgcgc tccgttgtgg aatccggatg tacgcggctc atttttcggc ttgaccatgt 3808561 cgcataagaa agagcatatg atacgcgcgg cattggaagg cgtcatttac aacctgtaca 3808621 cggtgttctt ggcgttaact gaatgcatgg atggcccggt aacccgcatc caagcgacag 3808681 ggggttttgc aaggtcggag gtttggcgcc aaatgatgtc ggatatcttc gaatcagagg 3808741 ttgtcgttcc ggaaagctac gaaagctcat gtctcggcgc ctgcatttta ggcctgtatg 3808801 caacaggaaa aatcgattct ttcgacgccg tgtccgatat gatcggcagc acatacagac 3808861 atacgccgat cgaagactca gccaaggaat acagaacatt aatgccgatt ttcatcaatc 3808921 tatcaagatt attagaaaat caatatacac aaattgcaga ttatcagagg ggcttaatca 3808981 cacacaaata gtacatgaca tgaaggggag ggcattacca tgccgttaat catcgttgca 3809041 cttgggatct tagcattact atttctgatt atgggcttaa aattaaacac atttatttcc 3809101 ctgctggtcg tatcgttcgg cgtggcactg gcactcggga tgccgttcga taaagttgtc 3809161 agctccatcg aagcaggaat aggggggact cttggccaca tcgcgctcat cttcggactc 3809221 ggtgcgatgc tgggcaaact gatcgcggat tcaggaggcg cacagcgcat tgcgatgacg 3809281 ctcgtcaaca aattcggtga gaaaaatatt caatgggccg ttgtcattgc ctcattcatt 3809341 attgggattg cgttattttt tgaagtagga ctggttctat taattccgat tgtctttgcg 3809401 atttcaagag aattgaagat ttctatttta tttctcggaa tcccgatggt cgcggcacta 3809461 tccgtcacac acggtttcct gccgccgcac ccgggaccta cggcgatcgc cggtgagtat 3809521 ggcgcaaaca ttggagaagt gctgctgtac ggctttatcg ttgctgttcc gacagtgctc 3809581 attgcagggc cgttatttac aaagttcgcg aaaaaaatcg ttcctgcatc atttgcgaaa 3809641 aacggcaata ttgcatcact cggcacacaa aaaacattta accttgaaga aacacccggc 3809701 tttggaatca gtgtctttac tgcaatgctc ccgattatca tcatgtcggt cgcgaccatt 3809761 atcgacctgc ttcaagaaac aatcgggttt gcagataacg gagttttagc ttttatcaga 3809821 ttgattggaa acgcatcgac tgctatgatt atttcgttat tggtcgcagt ctatacaatg 3809881 ggcatcaagc gcaacattcc agtcaaaacc gtgatggatt cttgttcaac tgccatttca 3809941 caaatcggca tgatgctttt gatcatcgga ggaggcggcg ccttcaaaca agtgctgatc 3810001 aacggcggtg tcggcgatta cgtagcagac ttattcaaag gaacggcatt atcgccaatc 3810061 attctggcat ggctcatcgc agcgatcctg cgcatttctc taggatcggc gactgttgcc 3810121 gcactaagca caacaggtct ggtcattccg ttattgggcc attctgatgt taacctggcg 3810181 ttagtcgtac tcgcaacagg agccggaagt gtcatcgctt cacacgtcaa tgacgccggc 3810241 ttctggatgt tcaaggaata cttcggatta agcatgaaag aaacattcgc cacatggaca 3810301 ttgctggaaa ccattatttc cgttgctgga ctgggattca ttttattgtt aagtttagtt 3810361 gtatgaaatt aagaaggagc tgtaacacat gttcaattcg attggtgtca taggcttagg 3810421 cgtaatggga agcaacatcg ccttaaacat ggcaaataaa ggcgaaaacg tcgctgtcta 3810481 taattacacc agagatttaa cggaccagct tatccaaaag ctggatggac aatctctcag 3810541 cccgtattac gagcttgagg actttgttca atcgttagaa aaaccaagaa aaatcttttt 3810601 gatggtcaca gcgggaaaac ccgtagattc cgtcatccaa tcattaaagc ctttgcttga 3810661 agaaggcgac gtcatcatgg acggaggaaa ctcccactat gaagacacag aaagaagata 3810721 tgacgagctg aaggaaaaag ggatcggcta cctgggagtc ggcatttccg gcggtgaagt 3810781 cggtgcgtta acagggcctt ccatcatgcc gggcggagat cgcgacgtct atgagaaagc 3810841 cgctcctatc ctgacgaaaa tcgcagccca agtcggagat gacccttgct gtgtctatat 3810901 cggaccaaaa ggggcagggc actttacaaa aatggtgcac aacggcattg aatatgccga 3810961 catgcagctg attgcagaag cttatacgtt tctaagagaa acgcttcgtc tgccgctaga 3811021 tgaaattgca tctatttttg aaacatggaa tcaaggtgag ctgaaaagct atttaataga 3811081 gattacagct gagattttac gcaaaaaaga cgaaaaaaca ggacagcctc tgatcgatgt 3811141 catccttgat aaaaccggcc aaaaaggcac cggaaaatgg acgagcatgc aggcgattga 3811201 taacggcatc ccgtccacga tcatcacaga gtccttgttc gcccgctact tgtcatcttt 3811261 aaaagaagaa cggatggcag ctcaagatgt attagcaggc ccggaagccg aagaaaaaca 3811321 cttggataaa gacacttgga ttgaatacgt cagacaggct ctttacatgg ggaaagtatg 3811381 cgcctatgca caaggctttg cccaatataa gatgtcatct gagctttacg gctggaatct 3811441 gccgctcaaa gacatcgcct tgattttccg aggcggctgc atcatccgcg ctgatttcct 3811501 aaacgtgatc agcgaagcat tcagtgagca gccaaatctg gctaacctgc tgatcgcgcc 3811561 ttatttcaca gataagctcc atgcctatca aacaggcctg cgaaaagtcg tttgcgaggg 3811621 tatcagcacc ggaatctctt tcccatgctt aactaccgcg ctctcttatt acgacggcta 3811681 ccgcacaggg cgttccaatg cgaacctctt gcaggcacag cgcgattact ttggcgctca 3811741 cacgtacgaa cggactgata tggacggcgt cttccatacg aattggtctg aataacctgt 3811801 attaaaaaca cggtcagttt caactgaacc gtgttttttt cttctatccc aaacaacaga 3811861 agacataagt tatgttttaa atatcataaa cagtgataca ataatagcta gaaacaatcc 3811921 ccaagatcat catgtgacag cagattgctg ttccgttcta ttctgctttt ggccattgtc 3811981 ctttgccctt gaccatggtg tcataaaatg ttcaaatgcc aaaacggcct ggcattctga 3812041 tttacaaaag tccctgaaaa ccttatctaa ttgagaatca gcctctcatt tattataaaa 3812101 gaaatgccta aatcctacct gtcacacctt tattaagatg aaaaaaagta ggttatggct 3812161 tgacaaaaaa tatatattaa ttaataattc atatataatt agaattatta ttgaaagcga 3812221 ttatgctttc taatacattt ttaggaggaa tatacattat gtctttaatc ggtaaagaag 3812281 tacttccatt cgaagcaaaa gcattcaaaa acggtgaatt catcgatgta acaaacgaag 3812341 atttgaaagg ccaatggagc gtattctgct tctacccagc agatttctct ttcgtatgcc 3812401 caactgagct tgaagatctt caagaacaat atgctgcact taaagaatta ggtgttgaag 3812461 tatactctgt ttctacagat actcacttcg tacacaaagg ctggcatgac agctctgaaa 3812521 aaatcagcaa aatcacttac gcaatgatcg gtgacccatc tcaaacgatc tctcgcaact 3812581 tcgatgttct tgacgaagaa actggccttg ctgaccgcgg aacattcatc atcgatccag 3812641 acggcgttat ccaaactgtt gaaatcaatg caggcggtat cggccgtgac gcaagcaacc 3812701 ttgtaaacaa agtaaaagca gctcaatacg ttcgtcaaaa cccaggtgaa gtttgcccgg 3812761 ctaaatggga agaaggcggc gaaactctta cacctagcct tgatctagta ggtaaaatct 3812821 aaggagtgca ttcaattggt acttgatgca aatatcaaag cacaattaaa tcaatatatg 3812881 cagctaattg agaatgacat tgttctcaaa gttagcgcag gcgaagatga cacttctaag 3812941 gacatgctgg ctctcgttga tgagctggct tccatgtcat cgaaaatttc agttgaaaaa 3813001 gctgaattaa acagaacgcc gagcttcagt gtcaatcgtg tcggagaaga cactggcgtg 3813061 actttcgccg gtatccctct gggccacgaa ttcacatcat tagtgttggc gttgctccaa 3813121 gtgagcggca gaccgcctaa ggtagaccaa aaagtcattg atcaggtgaa gaagatcagt 3813181 ggtgaatacc acttcgaatc ttatatcagc ctgacatgcc acaactgtcc tgatgttgta 3813241 caagctttaa acatgatgag cgtgctgaac ccgaacatta cgcacacgat gattgacggt 3813301 gcagcataca aagcagaagt tgaaagcaaa aacatcatgg cagtgccgac cgtttacctg 3813361 aatggcgaat ccttcggaag cggccgtatg acgcttgaag aaattcttgc gaaaatgggc 3813421 agcggcacag atgcatctga gtttgctgac aaagagccgt ttgacgttct tgtggtcgga 3813481 ggcggacctg ctggtgcaag tgcagcgatc tacactgcac gtaaaggcat ccgaactggt 3813541 gttgtcgctg agcgcttcgg cggacaggtt ctcgacacca tgagcatcga aaacttcatc 3813601 agcgtcaaag cgacggaagg accgaagcta gcggcaagtc ttgaagagca tgtgaaggaa 3813661 tatgatattg atgtcatgaa ccttcagcgt gcgaaacgcc ttgagaagaa agatctgttc 3813721 gaacttgaac tcgaaaacgg cgctgtcctg aaaagtaaaa cagtgatcct ttcaacaggt 3813781 gcacgctggc gcaatgtcaa cgtccccggt gaacaagagt tcaaaaacaa aggtgtcgca 3813841 tactgcccgc actgtgatgg gccattgttt gaaggcaaag acgttgcggt aatcggcggc 3813901 ggaaactctg gtatcgaagc agcgattgat cttgcaggta ttgtcaatca cgttactgta 3813961 ctagaattcg cgccggaact gaaagcagac gaagtcctgc aaaaacgtct ctacagcctg 3814021 cctaacgtta ctgtcgtgaa aaacgcacaa acaaaagaaa tcacaggtga tcagagtgtt 3814081 aacggcatca catatgtaga ccgcgaaaca ggcgaagaaa aacacgttga acttcaaggt 3814141 gtattcgtcc aaatcggtct cgtgccaaac acagaatggt tagaaggaac ggttgaacgc 3814201 aaccgcatgg gcgaaattat tgtcgacaaa cacggcgcaa caagcgtacc aggcttattt 3814261 gctgccggcg actgcacaga cagtgcgtac aaccaaatta ttatttctat gggatcaggt 3814321 gcaactgccg ccctcggcgc gtttgattac ctaatccgta actaatataa gaaatccgct 3814381 atattgccag attggcagga tagcggattt ttctttttct acagaaaaaa accgaaccag 3814441 gcactacggt aaaagtgctc gattcgagcg cttcttatag ttcctcacca ttcgtttgaa 3814501 tgacattttt ataccactca aaggagtctt tcttatatcg tttcatggat ccgtttcctt 3814561 cattgtcacg atcaacatag atcatgccgt agcgtttttt catttcgcca gttgtgaagg 3814621 agacaatatc aataatgccc cacggcgtgt agccaattaa atcaacacca tcgtacgtga 3814681 ccgctttttt caatgcttca atatgcgatt ttaaatattg aatgcgttcc ggatcatgaa 3814741 ccttgccgtc ctcctccagc gtatccactg cgccaaagcc attttcaacg atgaataacg 3814801 ggatttggta tcggtcataa aaacgattta acgtatatct caacccggtt ggatcaatcg 3814861 cccatcccca gtcactcgaa gtgatgtacg gattttcgac accattcggc aagccgccat 3814921 ttacaatatc gccagtgtta tcatttttca catcgctttt cacagttgtt gacatgtaat 3814981 agctgaagcc taagtaatcg acggttccgt ttcttaaaat ctcatcatcg ccgtcttcga 3815041 atgtgatgtt gtagccttcg cgttcaaatt ccttcaacgc gtagcttgga taataaccgc 3815101 gaacctgcac atcagggaag aaatagcgct gcctcatttc ttcttcagcc agcatcacat 3815161 cttcaggatt ggaggagaaa ggataaatcg gcacgtgtga taccatggcc ccaatctgga 3815221 actctggatt gatgtctttt ccttttgcca ctgctaaggc gctcgccact aattcatggt 3815281 gcgccgtttg atacatgact tccttggcgt tttcgttttc gccaaccaca acacctgaat 3815341 tcgtccatag gaacagcgga ttgttcacat ccatttggtt gttaatctcg ttaaatgtca 3815401 tccagtactt cactttatct ttgtaacggg taaagcaagc ctctgcgaag ttgacgaaga 3815461 agtccacgac tttccggttt ctgaagccgc catattctct tgccaggtgc agcggcattt 3815521 caaagtgaga cagggtaatg accggctcga tcccatgctt cagcaattca tcaaacacat 3815581 catcataaaa ctgcaaacca gcttcgttcg gttcagcctc atcgcctttc ggaaaaatcc 3815641 ggctccagcc gatggacgtc cgcagacatt ttaatcccat ttccgcaaac aaagcgatat 3815701 cttccttgta tctgtgatag aaatcaatgg cttcatggtt tggataaaat tcgttttctt 3815761 caatcgtgtc agtgattttt ctcggcacgc cgtgcgcacc cgctgtcatc acatcgacga 3815821 cactcggccc tttaccgcct tgattccatc cgccttcaaa ttggtgggca gctaaagcac 3815881 cgccccataa aaaatccttt ggcatgtttc ccatgtttaa ttcctcctca gcttacgact 3815941 gtaaatattt tttgatgtaa tgcactttcc tcaatgtctt caatgaaagc tttatcaaac 3816001 tcaacaagca cttcgccttt tttgacggta tcgccttctt ttaccttcaa ggaaaaaggc 3816061 gtgccgtcaa atgtcaccgt atccagcccg atgtgcgcaa gcaattcgac gccggacgct 3816121 gaacgcaggc caatcgcatg ctttgtaggc gtaaccatga caaccgtaat gacgccggga 3816181 tggtagcatc gatttcacga tatccttcgc tttaggggta gaccgcttca gcaccaatcg 3816241 aagtctggta gcgcagcgag aagccccaat cacattctct tccccgccta cggcctctaa 3816301 aatgtctttt gctagtctcg tataatctct cactttcccc gacatttcac ccaccccttc 3816361 gttttggtta cgctttcatt ataattgtaa cggtataatt tatcaattcc gaaacaaaat 3816421 atttacgcac taactatcat tgtaagcggt ttatgctata attttgacaa gtgaaactaa 3816481 acgaataaat gaggaatgcg tatgttaaaa taccagcaaa tcgcaacgga aattgaaaca 3816541 tatatagaag aacaccagct tcagcaggga gacaaactgc cagtcctaga aaccctcatg 3816601 gcccagtttg aagtcagcaa aagcaccatc acaaagtccc tcgagctatt agagcaaaaa 3816661 ggcgcgatct ttcaggtcag aggaagcggc attttcgtca gaaaacataa acgaaaaggc 3816721 tatatcagcc ttctgtcgaa tcagggattt aaaaaagatc tcgaggattt caacgtcacc 3816781 tcaaaagtca tcgaactgga cgtgagaaag ccaacaccgg aagcggcgga aaacctgaac 3816841 atcggaatgg acgaggacat ctactatgtc aaaagggtcc gctacatcaa cggccagacc 3816901 ctttgctacg aagaatccta ttacaccaaa tccatcgtga cgtatttaaa caacgaaatc 3816961 gtctcccact ccatcttcca ttacatccgg gaaggactgg ggttgaagat tggtttttct 3817021 gatttgtttc tgcacgtggg ccagcttaat gaggaagaag cggaatattt gggattagag 3817081 gctggactgc cgaagctgta tatagaaagt atttttcacc tgacaaatgg gcagccgttt 3817141 gattactcga agatttcgta taattatgag cagtcgcagt ttgtggtaca ggctaatagt 3817201 tttttattat agggctcttc actacggtag gtggtcgaca tgtacaaaat tatcattcct 3817261 gccatactag ccatctttgc gctctggata ctcttacaga tttcactaga gatgagcatc 3817321 gttaagaatc caatgaacta ctttatcgta ttcattatct ttttcctctt tgtaaagatg 3817381 gtgaaagaaa aacaataata gtttgggcga tgcaaacaga aaaacatcct tcccttaaca 3817441 aactcagcca gtcacatgca ttaatcttga tgttaatgat atataggtgc acataaaaag 3817501 ctacttcatt gtgaagtagc tccctttatt aaaggcccat tttgatccat ctagttttag 3817561 aaaagcgaag gacaatcgca tttatgataa taattgaaac taaatacaaa ataataaata 3817621 aaacatcatt actcccaagt gtcatgttat cagattgcag cactctttct attcgggggt 3817681 acatagtgtt acctgcctca aaaggagcaa tgaaaccaaa cgttttattg cttatagcta 3817741 ctaagataac agaagtcatc caataaacga tactgacacc tatactaatt aatatattag 3817801 gacataacac gcttatagtt ccgataatta gaatatactg cagtataact gcagaaaata 3817861 aaaaaagtaa taatgcaaaa tgcgaaaaat catggtacat caacgatatg attagcaggc 3817921 ctagcgttat aaatgcaaaa cattctaaaa ataaaacagc tatcttttta taaaagaaag 3817981 tatagatgtt ctctccaatt aacttgtaaa agagaatatt tttgtttgaa tactctctat 3818041 taataaagaa agctataaca aatgaaaata acatcaaacc aaactgggtc gcaacagtat 3818101 aggagctaaa gaaaaacatt tcaggtgtaa cattactgac tttatcgatt ccaacaagta 3818161 aaaaataacc cagcaaaaat aaaaatacaa acattgctcc taaaataatg ataactttgt 3818221 tgctaatact ctttttaaac tctaatttca tctcaagccc ccactgtttt attactcatt 3818281 tatatacact tcaattaatt tatccactga atgatattgt tgaatttctt ggtgattaaa 3818341 tatataataa tccccttcta tcgcctttaa atcagacaaa tcatgtgtaa tgttgatgat 3818401 aatcttctcg gggttctcct gaatatactt gtttaagaag ccatgaatct ctataaccgt 3818461 ttttttgtct aatgaattcg ttatttcatc taaaacaata atatttttat cctctaataa 3818521 gaaactgagc aattttaatt tttgcttttg tccatcactc aaatttttga tcagaacttt 3818581 tccatcaata ttatccagat taagtaaata tgcgatttta tctatcattt ttgcatcaaa 3818641 ttttttactc aaaaagtgta ataaaaagtc cttagaaaca tcattaggta tattcgacga 3818701 gctggatatt aaagaaacat tttgacgaat atctctgccg attcttttgc tattattcaa 3818761 caaaaagtct ttagcaagct gtgatttacc gactccattt tttccgacaa cgtgattaat 3818821 tttcccgctc gaaaaatgca agtcggtgtc ctgaagtaac gttttgcctt tcacttttaa 3818881 agtgtaattc gctatattca tatacatact cctaggaaat atttgcataa taataaaatg 3818941 ttctgccttg tgatttgtta ctaatgtcta agcttttgag gtacctcttt cgtttccgat 3819001 ccggaagcga aagaaatgtt tttagatggc taatttggag atcttttact ctagtttaca 3819061 atatataata tccaatgtac aactgaattc actgcaaggc caatccctat aatttgaatc 3819121 gtaagaacta accaatgatt tgtcttaaaa cggctatatt catctaagct cagaaaagct 3819181 aaaagaattt tgtaaccatc agaattcaat attgggatta agttccacaa taaagtagac 3819241 gagaaaagca taaatgccat agttaatgct tcactggaaa atgtaaattg atttattaat 3819301 tctaatgtat ttattaaaag ataattgata aacaagccaa ataaatgaac gattatcttt 3819361 tcatttcttg atagcatgta ggtttcattc aattggacat aaaaagcagg aaatacataa 3819421 aaattcagtt tgaatcccac tttatcaaag tttttcccga aaaattttaa ggaataaata 3819481 tgtcccagtt catgaagcac tatattcatt ataaaataaa taactataat tatccacatt 3819541 ttccagccgt aaaatactga ggacaatcca ttttgcaatt ttattaaatg aatataattt 3819601 aatatgaaca tgagagccgt aaaggataag aacagataaa aaaactttgg tgatactttc 3819661 tctttataca ttttaaaacg taataattgt ttatctgaca gagaatttaa actattttta 3819721 tagtattctc cgcttttttt gtcttttata aatacgttgt tttgcacaag cacttcatat 3819781 ttttcatctt catactttaa aattttcatt atagtatttt tccatataag gatagaagta 3819841 gtttattttt tctgcagagt tgaataagga accacaaact ccacaaatag aggaaaattc 3819901 ataaggaatg tcaaattcct ctattttgtt attttctttt aaaatattca aaaaccattt 3819961 gaatccttct tttctaagaa taaataatag caaattggaa tttaactttt ccacggttct 3820021 ttcgaaactt tggttatatt cttcccttag ggttattttc gtttcaaaaa tagcagggga 3820081 acaacatgga taaatttctc catcatgatg atatacaatg tcatatccgg gacaatgtaa 3820141 ggaatcttca tcttcaagac tgtaaaattt atgtatgttt tcttgcttaa ttctagtttt 3820201 agcagcgcca actgatatca ttggaaattt tgttatcttt acacctaaga ttgaatcccc 3820261 caattcctct aaaatgtggt tggacatttt gtctttggta actgccatat taagagaaat 3820321 atcgatatca gggtatttcc tgctatgttc taatatgttt ttaatactgg aagacttgac 3820381 aaatggagca tggtactcat cataacttat agtcagtgct atcacattta aagaattcat 3820441 atcatgaaag tactcctgga cctttttctt gctcaaaccc caaaatccat tagagatcaa 3820501 cgttatttgt ttttcatatg gtttaatgat ttccattagt tcttttaaaa atttataatc 3820561 taaaaaaact tccccacctg taaaagaaat cacttgaatg gttttgtttt ttgcaaattc 3820621 agttactaac tctcttatgt attctttttc catcctggtt gttgaagttg gtgaactaga 3820681 aaaacaacaa tggtcacagg atgcattaca ccttgaatct aaattgattg atactgtttt 3820741 attatacatg aaatatcccc caacaaatgg taaaggagag ttagactctc ctttgtaccc 3820801 ctctaattaa tgaccacttc caagaatcca gcgattttct tttgatttta caaaatacca 3820861 aagatcattc acttttgcta acttttgtga ttcatctaat agacccttaa attctaagtt 3820921 tttcacagtc tcattgttag tgatttcctt tttcatatta tccctcctcc ttttctaata 3820981 taaaccaatt attctatatc attcaataca tgtcaatata ttgtacctaa aaaatctgaa 3821041 aaatgtcact attcttggta tataaagcct atagtcctct agcccctcta agctataccg 3821101 aatgaaaggc catagtttga tttaaagctt cgtaatgaaa agtaaaacat caatattgac 3821161 tacactagtt aagggatata cagattttaa gtggaagaaa tgaggcaaac aatcttaccc 3821221 taaaccaacc tgtactgaaa agctgtttta agctcttgct taccccattt ggcacctctt 3821281 tctctcgttt taattgtctc taaaagcagt tatgcggtac tatcatataa aggtccaatg 3821341 tttaaaaata atgtcatact tttaaattca ccttatcatg cacatgctca taaagagggg 3821401 tttattctaa aaaggggatg gacggttttg gaaagcaagt acctagatct actcgcacaa 3821461 aaatacgatt gtgaagaaaa agtggtaaca gaaatcatca atttgaaagc gatattgaac 3821521 ctgccaaaag gcaccgagca ttttgtcagt gatctgcacg gagagtatca ggcattccag 3821581 cacgtgttgc gcaatggttc aggacgagtc aaagagaaga tacgcgacat cttcagcggt 3821641 gtcatttacg atagagaaat tgatgaatta gcagcattgg tctattatcc ggaagacaaa 3821701 ctgaaattaa tcaaacatga ctttgatgcg aaagaagcgt taaacgagtg gtataaagaa 3821761 acgattcatc gaatgattaa gctcgtttca tattgctcct ctaagtatac ccgctccaaa 3821821 ttacgcaaag cactgcctgc ccaatttgct tatattacgg aggagctgtt atacaaaaca 3821881 gaacaagctg gcaacaagga gcaatattac tccgaaatca ttgatcagat cattgaactt 3821941 ggccaagccg ataagctgat caccggcctt gcttacagcg ttcagcgatt ggtggtcgac 3822001 catctgcatg tggtcggcga tatttatgac cgcggcccgc agccggatag aattatggaa 3822061 gaactgatca actatcattc tgtcgatatt cagtggggaa atcacgatgt cctttggatc 3822121 ggcgcctatt ccggttccaa agtgtgcctg gccaatatta tccgcatctg tgcccgctac 3822181 gacaacctgg atattattga ggacgtgtac ggcatcaacc tgagaccgct gctgaacctg 3822241 gccgaaaaat attatgatga taatccagcg ttccgtccaa aagcagacga aaacaggcca 3822301 gaggatgaga ttaagcaaat cacaaaaatc catcaagcga ttgccatgat ccaattcaag 3822361 cttgagagcc cgattatcaa gagacggccg aactttaata tggaagagcg gctgttatta 3822421 gagaaaatag actatgacaa aaatgaaatc acgctgaacg gaaaaacata tcaactggaa 3822481 aacacctgct ttgcgacgat taatccggag cagccagatc agctattaga agaagaagca 3822541 gaagtcatag acaagctgct attctctgtc cagcattccg aaaagctggg ccgccatatg 3822601 aattttatga tgaaaaaagg cagcctttat ttaaaatata acggcaacct gttgattcac 3822661 ggctgtattc cagttgatga aaacggcaat atggaaacga tgatgattga ggataaaccg 3822721 tatgcgggcc gtgagctgct cgatgtattt gaacgattct tgcgggaagc ctttgcccac 3822781 ccggaagaaa ccgatgacct ggcgacagat atggcttggt atttatggac aggcgaatac 3822841 tcctccctct tcggaaaacg cgccatgacg acatttgagc gctatttcat caaagagaag 3822901 gaaacgcata aagagaagaa aaacccgtat tattatttac gagaagacga ggcaacctgc 3822961 cgaaacatcc tggcagaatt cggcctcaat ccagatcacg gccatatcat caacggccat 3823021 acacctgtaa aagaaatcga aggagaagac ccaatcaaag caaacggaaa aatgatcgtc 3823081 atcgacggcg gcttctccaa agcctaccaa tccacaacag gcatcgccgg ctacacgctg 3823141 ctatacaact cctacggcat gcagctcgtc gcccataaac acttcaattc caaggcagaa 3823201 gtcctaagca ccggaaccga cgtcttaacg gtcaaacgat tagtggacaa agagcttgag 3823261 cggaagaaag tgaaggaaac gaatgtgggt gaggaattgt tgcaggaagt tgcgatttta 3823321 gagagtttgc gggagtatcg gtatatgaag tgaggggtgt ggggttcagg gatggtgata 3823381 tgctgctccc ctaaaagtag atagatgaat tttagaaaat ctgtttgcct tggggagttt 3823441 tttcatggct ggacaattat actacaagga agaaatacta atacttatag aatgtaattg 3823501 ggtaatgatt cggagaaaga ggttgcgaaa taatatggta ttacactgaa acaattatca 3823561 atggagaaca tgcacgatat agccgttcta tattctccct ctattatggc actcattagt 3823621 agacataacc gtaaaaaaat gcactcaaaa aaagtccatt ctatataact ctcgctaggg 3823681 tggacctttt tcaacattca aagtactaga ttttttctag tgaaagaata agaaaagaca 3823741 taagttctat tttatcactc tgttataggt taagttatta cggtgtttca ttatatactg 3823801 aatttaaaca cccttgacat tatgggaatt tttaaaacag gttaaaagga agttctataa 3823861 gaactcccta gtttaatatt atttggtcaa aatctaaaac caaaaaatct atttttatct 3823921 tcattgtttc tatctaattt tgcaacaatc atacctttcg actctaattc ttgaaggtca 3823981 tctaataata attcattttt atttattgtt acaaaatatt gtccgatcct attctctaac 3824041 agacttgaat tgatatgttt taataatgta ccttttacat gaggatcagg attagaataa 3824101 gatccgtcat gaattaaaat attcaaacta cacttattta tacacctgta taaaaaccaa 3824161 gtaagatcaa atatatttat cttcatatgg agtctaccat gtgaacgttc atccggtata 3824221 gaacaagaaa ttttgatcct tcctgtagtt gattgttttg cgttacttat tctattatca 3824281 tattcaaaat ctaaaaatcc atgttggttg tatgtaacat ccattagatt attaaaaagc 3824341 ttctttaact cactaactat agcgctataa gattgaaact catcataata cattgaatta 3824401 actcttaata tttcatgttg aagttcatta atcttatcaa aaatatggtt ttttttatcg 3824461 tagtcactaa ttctcaatct tacttccgct aactctattt ctttccttct ttgttcttcc 3824521 atcacaatgg aaatatcctc aatgaaattg ttactcttta aaattctggc acttgattcc 3824581 agttgttctg ttaatccttg ctttttgata ttaagttttt ttaaatcggc ttgtatttta 3824641 acaattttat ctttaaaata actccctcta ctttctacca tgaaattata gaactcttgg 3824701 actttattat aattctgttt tacttcctct ggaaaaaaac ctacaatatc ttcatagaat 3824761 ttttctatat tttctaattc tttaatctta gttacttttt tatttaaatc atctatattt 3824821 ctttgatatt gtttacaaat atgttcattt tcaaatattt cattttgtat tttattaagt 3824881 tcacttttaa tttctgagta cctatttgta tcattattat atttattggc agtcttagtt 3824941 tgatagataa ctctattgta atcctctatc tcatttatta attcatcttc cttaactttt 3825001 aaatcgccaa tgttaatatt cattgattca atcaatttta tttcactatt taatttttca 3825061 atcttatccc gaaaaacctt tatgtttttt tctgtatgag ttggtaaagt aaaaagatag 3825121 ttaagtaatt tatattgttt taaccctccc ctattcggta aaactatatc attaaaccct 3825181 gtcttttcgt ctcttataat atactccctt aacgccgcaa aagttatatc ctctttctca 3825241 ccctttaaaa tttccttttc aataaatttt ttatatacac ttatactaac ttttttccat 3825301 tcctccaaat taaaagttaa agaagtatca tgtaatgtat aaccatgttt aggagaatta 3825361 aaagatctag caaggaatac ttgatttcca tcaatttcca cattcaaaac aataaaaacg 3825421 tttttattga gaagaatttc atttgtcgta taaaaatttg atatagtctt ccctagtaaa 3825481 aaggagatgc attcaatcat cgttgactta cctacaccat tagtctcttc atgatcttct 3825541 ctcttttcac caagtattat atttactcct acagcattaa atttatactc tttcaaaatt 3825601 tcttgggaat tgcaaacaaa aagatttttt ataatcataa caatcactaa ctctccgttc 3825661 tgctaatcat attttgatta aaagaaactt tacctaatga atataaaaaa gttaacgata 3825721 aatacagtat ccgttcaata ttcaaattta ttataatacc ttgactctta gcataatcaa 3825781 gaaaaagttg atcaatatgt ttttccttct ctaacagttc ataaagtatc tttgatgagt 3825841 ataaaatatt ttcttccaca gcattatatt tagttaataa aaaatgattc atttctggcc 3825901 tctccgcctt ttcctttttt aaaggagaat tattcactag aggaataaga tcatttccaa 3825961 tttgaatgtt tttaaactca ttttctaata aaacataaga gtatttgaga atattttcag 3826021 ctgtttcaat tttaagatca atcattctta acacttcttt tgttatcatt aaaaatctca 3826081 cattcataaa tgcaccaaca tgttaaaatc ttaatgtatt ttttcgttaa agcctttgaa 3826141 tatggtaaaa ctgaatgaca ttctagataa atctcattaa caatttttac aaatatctca 3826201 tctccattat tatattgatt atgaaactct agatatttgt ctactatcgt ctcagcaatc 3826261 aattcctttt tatcagcact tacatacgaa gtggaatcca ttatatggtt tatcacacca 3826321 aaatactcag aataactatc gaatttccgt ttaaaagttt ccccactttt catatcataa 3826381 aattttttat ctaaaccaat ttgattatca aaattactag taaatgtttt ataactttct 3826441 ctatactcat gaaaatctat aataaagctc ttaaactcat cttcatcaat tttatcatcg 3826501 ttatcttcta tttctttttc aataaggctc tctaatctat taatcttata atttaacttc 3826561 ccttcctgta gtctccttcc tccttggttg ttttttgacc agtatttata ttcggtattc 3826621 caaatgtagt atgttacttc tgtctcgcca ttatctaaat tcacatccac cgaaataaat 3826681 tctggagtag catactcatc ctttataatg gctccactta ctaattctaa gaatggattt 3826741 tcatttgtat ttgcagtaat attaaatgaa gaatcatgta catgtcctgc caaatataga 3826801 tcaataaagt aatcatcaaa atgtgccttt attgattctc tttcggaaga ttcaatacaa 3826861 cctaacgtat ggtgcccaat agctatattt aataccttgc ccttattttt ctctttgttc 3826921 atcttcctta ttgctttata taatttcatc tgtgcagtta ataacgttcc ttcttcacct 3826981 tttttatctg ataacagaca tgtatttatt gataaaacat tatacttctc cgattgatac 3827041 aaaaaatgca aatcttcttc cggatattta acacccataa aatcttcata aaaatcgaaa 3827101 aatttccttt gaccttccac taatatattt gtagcttttt gatctagttt atccaacatt 3827161 tctgaggggt taggagattt cataatacta tcaatcaaaa gtgtcctcgt catgtctcta 3827221 gatatatcgt gatttcctgg cactaagtgt acgttattct tacttaatcc catactttta 3827281 ataattccat taagatattc tttaacatct tcgttataca catcaccttt gtgtgctata 3827341 tctccagtta ataataaaaa atcaaaatct gactctcttc ttaaaacttc tataaaatct 3827401 aataatttat ctctcattac aatagtgtca taattttgaa actgaaaatg caaatcagaa 3827461 atttgtaaaa aacgtacctt caatacaaac atcctctcat aagtatattt atcccctata 3827521 tatttctaga aaacttttta ttctatatca tctttactct ttaatatatt aagactcttt 3827581 ccacaccatc aaataaatta taacctaaac ataactcttt actcatttta gtattgtatt 3827641 taagtcaaac attgcattgg ttgctgaaat attatattca ttgaattatt ccattaaata 3827701 gcttttagtt gaactttagt ctttctgtaa tggtggagat gctcttactt atgataaggc 3827761 tccccacgat taatccgaaa agcccgataa atctgctcca ctaaaataag ccgcatcaac 3827821 tgatgaggaa atgtcatctt cgagaacgat agcttctcgt ccgctcgctt catcaccgtg 3827881 tcactcaatc cgagtgatcc gccgatgacg aaggtgactt tgctttttcc ataagtagcc 3827941 agcttatcta ttgtatcggc tagttcttcg gatgttttca tttttccttc gatggcgagg 3828001 gcgatgacgt gggcgtcggg gctgattttg gataggatgc ggtcgccttc tttgtctttt 3828061 atgattttca tgtcctggtc gcttaggttt tccggcgctt tttcgtccgg gagttcgatg 3828121 atgtcgattt ttgcgtaggc cgaaagtcgt ttggtgtatt cttcaatgcc ttgcttgagg 3828181 tatttttctt ttagttttcc gattgtcaca atattgatat tcacaggtca tccccacttt 3828241 aaaaacaagt tattcatata tgttgtccac aattgtggat atcttttctg tattttgtgt 3828301 aagatcattc gttccccact atatatactg cggggtctcc acataattca caggctgtgg 3828361 ataaactgtt agtatgttcg atttttctga tttcgggcgg cagctcgtgg tcgtctatgt 3828421 acatatccag caccgtttcg atgtgttctt cacaagaata atacgcttgt ttcatgttca 3828481 aatcctccga tgttttcttc catttttaca aatgttctct tctcaatata acctatttat 3828541 tcacatgtta gtagtgcttc gggctgagtt ttatccacaa ttcgacaaac aagctgttga 3828601 tgactctatt tcgctcgtgt gttagtttgg atgtaaccga tgtgtgggga ggtctgcatt 3828661 tgcgctttag atgggtttgg ctttttgtga ttatgttgct gcttgctgag tgtcagccat 3828721 cttattgggt gttggagaag gatcgaatcg gtgaaggcag tccagactta gaaatatacg 3828781 ctaattatct ccaaatgcat gatgacgtga aaggatatca agtcttcacc atatcagaag 3828841 gcaaaaaaat ggtcgtcgtg tctctcggaa gcagcgagaa agataagaag cttgaagtgt 3828901 cggacgtcaa attctcatct aaagaaacga ttgtaactgt ggagcgaaaa cctgctccta 3828961 cggcaaatga gaaaaaccct tttattttga ttggactgga caaaattgaa ggggatttaa 3829021 ttgttcaaga cgaaacagga gatcgctttg aagaaacgga ttaccagcaa taaagccggc 3829081 gttctgagaa cgtccggctt tttcttttac ttcaatgtcc catgcgggtc gatgacgaat 3829141 tttttggctg cgcctttgtc gaagtcgctg tagccttttg gcgcgtcgtc cagagaaata 3829201 acggtggcat tgacggcttt tgcgatctgc gctctgccgc tcaggatcgc tttcatcaaa 3829261 ttgcggttgt atgtcatggc gggcgtttgt ccggtgacga aggtgtgggc tttggcccag 3829321 ccgagtccga agcggatttt taatgagcct gttttggcgt ccgcatcctt tgcaccggga 3829381 tcttcggtca cgtataagcc tggaatgcca aggctgcctc cgacctgggt gacgtccatg 3829441 attgagttca gcacggcggc tggcgcttct ccttgattgc cgtgcccaga tgcttcaaag 3829501 ccgacacagt ccactgcagc atcaacggtt ggttcaccta gtatttgttc aatttgctcg 3829561 ccgaggcggt cgtgtttttg cacgttgacc gtttcacagc cgaagcttct ggcctgtgcc 3829621 agcctgtctt cgttcagatc gccgacaatc acggtagagg cgcctaggag ctgagcggag 3829681 tgtgcagctg ccaagccgac aggacccgct ccagcgatat aaacggttga acctgtttgc 3829741 acgcccgctg tataagctcc atggaagccg gtcggaaaaa tgtcggacag catggtcaaa 3829801 tcgagaatct tttctagcgc ctgttcttta tcagggaata ccaaaagctg aaaatcagcg 3829861 tatggcacca tgacatattc agactggccg ccgacccagc cgcccatatc gacgtagccg 3829921 taagccgatc ccggccggtc cggattgaca ttcaggcaca catgcgtttt ctgcgttttg 3829981 cacatcacac agcgtccgca ggcaatattg aaaggaacgg atacgatatc tccttttttg 3830041 ataaattcaa catcacgccc cgtttcaatg acttctcccg taatttcatg cccgagcacc 3830101 aagccttctg gcgccgttgt gcggcctctg accatatgct ggtcgcttcc gcaaatgttg 3830161 gttgtaatga ctttgagaat aaccccatgc tcacattttc gattcacatt cgccttcggg 3830221 acgccgggcc cgtccctcaa gattaactcc ggataaccga tatcctccac cgctacagtc 3830281 cctttgcctt tgtacacaac cgctttgttt cctgtcaacg ccattcctcc cattcatgtg 3830341 tttggactct ccgtccttga acatgacttc ggttcggcat gactctttcc ctttttcacg 3830401 actgtttttt ctgtattctt acaacaacaa atatgccaag aaagcatcca ataatggttc 3830461 cgccgatgtc taagaagtcg actttacatc catttaacaa gaacacagta atggccgaaa 3830521 ccaggcagat cataactgcc agaagaataa cccgatttgt ctgcatgtaa ttcctccttt 3830581 ggattcgttt ctaaaccata cccaaaatcc tctgcaaact tcggttcaac aaaaaaagag 3830641 acttcacacc agtctcttca taaacagaga tcactcaaaa aatttcctga gaaataatgt 3830701 ggcaacactc gttactaacg caattgccgt atacataaca acccaaaata tgaatgagct 3830761 attccccgaa gctaacgtaa ctaacaatat caagctcgtg ataagaacga tgagcggtgc 3830821 cacccaaaat cttttaaata aaaaatgacc cgctatacca aatacacctg cgacgatcgg 3830881 aaaaccaaaa acgataaata aaacggcgat ggctcccata ctaccctcct tgccttaaaa 3830941 cctcttcatc acctcaacat catacagctt caaatgactc ttcggcgtca cgacatcctt 3831001 taccttccca atctcttttt ctttcatttt ctttccggtt ttcaggctgt actgttcaat 3831061 gtaggcaggc ttgtgatacg tgtatgtgaa gaaatagagg ctgctgcctt tttgggtgat 3831121 ttctttgaat tcggctttca ttttgtccgg ggaaagggtg aagacgatgc ttgtttttcc 3831181 tgtcttggca tcgattttgt gtacctttcc gaagccgtca atgaaataca ggttcccgtc 3831241 ataagggaaa aagctgtttt taaagctgaa gggcatggag ctgtatatcg tttgttcgtc 3831301 gtttttgtat tcggcgatat cgtgcagctc tacttcgccg ctttttttgt tgatcttgac 3831361 catttgatag agatcgtggg ctttttggcc gcgaaccata acatacacag cttggtcgtc 3831421 cacggcaagt tgggattcga ctgaggctcc ttcccggtac tgccattccg ttatgctgag 3831481 ataggtaagc ttcttctgat ctgcttgaat ctgaaggagc tgatagcctt ttccgtcatc 3831541 tgtcgggacg agtgcgtaaa tggcgccatc atggaaaccg gaggctcgga tgtagtaggg 3831601 gatgacgtct tttttccact ctccgtccat ttggcggtac agctctgagc ggtatccgtc 3831661 tccctttttg tcgtagccgg agttgtataa ggtgtaaaag ccgtccgtgt tttgcagaaa 3831721 gcccgcgctg tcgcctgtgt gctgataggt tcttttatgg gagcgcaggc cgtttttgat 3831781 cgtataaatc gtgtttttgt cctccagcat cacgctgtca ccgtgaacct ttgctgagcc 3831841 cagctcaagg cccttcatct gaaaggaaga cagcgtcccg tcatggctga taaacagggc 3831901 gtagcttttc ccgccgccaa atgcatcttg atccgcagag gatgagaaat acagcaggac 3831961 ttctttgtca tccaggaaat cgggatttct gagatcctgc tgactcacgg ttttatggct 3832021 tttgagagga gaaatgaaga caaatagtgc gattcctgcg agaatcagca tggcgatggt 3832081 aatcatccac tttttcatag ccttctcctt agtaaatggt cataatggtt gtcgtataag 3832141 aagaactagt gatgtcgcgc ggatacacgc ctaagcctcc gttgctgtct atatcaatcc 3832201 ctgctttcag caaaaaggca gaccatagga gctttgaaca gtttttggcg ccgtcatggc 3832261 cggtatttct gttattgacg aagttaaatg agtatgggtc gccgactttt gataccgccc 3832321 agtcggcagc agctgttttt tgagatgagg atacgctgac ggtttgcaca atggagttgt 3832381 cttccacgtc tctggcatta tacgcgatct gcctgacgcc gtcgctcggg acagattcaa 3832441 caattttgtc agcggcggag tacatgccga catggccgtg attgtagtag gctgtgtagg 3832501 agttcgtgta atagatattg cctttcgcgc ttgtcgggag ttttttcgtg ccggacgagc 3832561 cgcccatgat agacatgccg ctttccttgg cgagccggtc cccctctgct ttatcagccg 3832621 tgatctcctt atagaactgt tttaggataa cgtcctgctt tacgtgctgc tgtttggcaa 3832681 tctggctggc agatttcatg atttcttccg gtgtcgtgcc tggctgcagt gcggcgattt 3832741 cttcagcata atttgtggtc tttacggctt tggcgggagt aacaaacagg ccgccgcaca 3832801 ttgtgagcgc taccaaaaac atcgacactc gtttcttcaa cttcattaca tctcctcttt 3832861 tcttgtgagt gtaggaaagg taatttcctc acccacatta tattaggaaa ataaggaaag 3832921 taactaggtt atttacagaa tttttagaaa tcgtttacag aaaaaggcct ttatcaggcc 3832981 cttttcgtta aagcttcttg ctcatcacta cgtctgtttc ttgaaatccg gtttgctcat 3833041 atagctttcg agccgtctga ttatgggcaa agacatgaag ggacagcttg cggattccca 3833101 tactgcgtgc cgcttgatct aatgccgcca atgcttgctt tgcgtagccc tttccccgat 3833161 acggttcata taacccgaaa tcataaataa acgcttcctg ctgcggatgc tccggttcag 3833221 catgtatcca gagccagcca acgatatcct tttcattcag cttgaggctc cacaaatggt 3833281 gatggggtgt ttcgagccct ctcggaagca gatcagtaaa cacctgctta gacaaaagct 3833341 gggcatcttc aggcagccat gttcccgctt ttaccttttc ttccgcgtaa tgctttgttg 3833401 tgtacgtgag ataagaccga aattcttctg tctgcatagg ggttagcata attgtcatat 3833461 catctctcct tcatatattg actagaggat tttacataaa atagaaagag gtgttactat 3833521 cagaataagc aactgagatt gataagtcac tagagaaagg agtttcacat gaataagatc 3833581 gcacccgcag aaatcgctag catgctcaac gattggtacc ttgccatcaa gaaacatgaa 3833641 gttgaagaat cctcccgttt atttgaagaa gtgaagcctt tattggatga catggaagag 3833701 gatcaggagg tgcttgccta cttctcctta ttggaactgc gccacaaggt tttgcttcac 3833761 gaggcgagag gacagggctt tcagcatgag gagccttctc atatgaatgc tacgtctgac 3833821 atgctgaaat attacttttt tctgtttgaa ggcatgtatg aggcctataa aaataattat 3833881 gacattgcca ttgggctgta taaagatgca gagcagtatc tcgacaacat tcccgatccg 3833941 attgaaaaag ccgaatttca cctgaaggtc ggtaagctct attataagct gggacaaaat 3834001 attgtgtccc tcaatcatac acggcaagca gtcaaaacat tcagagaaga gacagattat 3834061 aaaaagaagc tggcttcagc cctgattacc atgtcaggca attttacaga gatgagccag 3834121 tttgaagaag ctgaggctta tttggacgaa gcaattcgga tcacgagtga attagaggat 3834181 catttttttg aagcccagct tttgcataac ttcggccttc tacatgcgca aagcggcaaa 3834241 tcagaagaag cggtttcgaa attagaggag gctctacaga acgatgagta tgcccgctcc 3834301 gcctattatt atcattctgc ctacttgctg atacgagagc tgtttaagat caaaaagaaa 3834361 gaacaggcct tatcttatta ccaagacgtg aaggaaaaat tgactgctga gccgaataga 3834421 atatgtgagg caaaaataga cattttatat gccatttatg cagaaggggg tcatgcggaa 3834481 acgtttcact tatgcaaaca acatatggat gacttgttgt ccgagaaaga gtatgacagt 3834541 gtaagagaac tttccatttt ggctggcgaa cggtataggg aacttgagct ttacaaagaa 3834601 gctgcccact ttttttatga agcattacag attgaagaac tgattaaacg aacggaggtt 3834661 atataaatga aaagatttct gattggcgca ggcgtcgcag cggtgatttt atcaggttgg 3834721 tttattgcgg accatcaaac ccactcacag gaaatgaaag tcgctgagaa aatgattgga 3834781 taaatgaaaa acccccgcgg gatgcggggg ttcaatttaa cgaaagaatc ctaaaacggt 3834841 ttgtagtttt aggattcttt catcttttca gcgtgattga aaacccttga agtctaggaa 3834901 gaacgagcat tggagcgcag cgaatgtttg gaattcgtga gcaccgaagc gcaggcctga 3834961 caacgaatgc gagggtttgt cgacacgctg aaacccccgc gggtgcgggg gttttcttat 3835021 tacagcagct tcttccctaa cagggattct acgagctcta ctgctgtttt gcccgttttg 3835081 tttttgtgat caaggatcgg gttaacctca acgaattcgg ctgaggtaat gatgcctgcg 3835141 tcatacagca tttccatagc caaatggctc tcccggtagc tgatgccgcc gacgacaggg 3835201 gttccgacac ccggtgcgtc gttcggatca agtccgtcca gatcaaggct cagatggacg 3835261 ccatcacatg ctgataaata atcaagggtt tcttcaatga cctttgtcat gccaagacga 3835321 tcgatttcgt gcattgtgta caccttcatg ccgctttcct taatgtactt gcgctcccct 3835381 tcatcaagtg accgggcgcc aatgatgacg acgttttccg gtttgatttt aggcgcgtag 3835441 ccttcaaggt taaccagtga ctcgtggcca atgcctaggc tgaccgcgag cggcatgccg 3835501 tgaatattgc ccgatggtga agtttcaagt gtattcaaat cgccgtgcgc gtcataccag 3835561 atgacgccga gattatcgta atgcttcgct gtgcctgcaa gcgtgccgat cgcaatactg 3835621 tggtcaccgc ccaggacaag cgggaatttt ttctcttcaa tgactttgtt gaccttttgc 3835681 gcgagttttt catttcccgc caaaacggaa ttcaggtttt tcagttcctc gtcatttttg 3835741 attttttcgc gattgatcgg aatgtcaccg agatcttcaa ccgtataccc catgtctgac 3835801 agcctctcga tcagatgagc gtaccggatg gcactcgggc ccatatccac tccgcgtcgt 3835861 gcttgtccta aatccattgg cattccaata accgaaatcg ttttatccat ctgtgattcc 3835921 acctcaacat ttaagataat gtcctatgcg ggttataaca aagatgactt gcggacaacg 3835981 tttttaaagc tctagctgac gatttgcctg ctggcgtttt ttaatgacga catgataaat 3836041 gatgtagcaa atgatcataa acggtacgcc gcaatacagc gcgatacgct gctccggatc 3836101 aaatgcaaga ctgatgagca cgaccgtatt taacgttagg ccgatcagcg gaagcaccgg 3836161 gtacagcggt gttttaaatt tcaaatcttc tatcttcccg ccctcacgga tatatttgcg 3836221 tctgaacatg atttgggaaa gcgagatcgt aatccagccg acctgcgcgc tcatgcccgc 3836281 caaagataac agtaccatat atacggtttc agcctgcgca aactttgtca gaagtgatag 3836341 gcaggccaca gccatcgtta cgattaacga gtacatcggt acaccgcgct gatttgtttt 3836401 gccaagcgct ttgaaggctt gtccttcatt cgccatcgcg tacagaatac gtgttgatgc 3836461 gtataaacct gagttcgcaa cagataacag tgcgattaaa ataacaaagt tcatgatatc 3836521 agctgcatat gggattccga tttgctcaaa tacggcaaca aatggacttt ccacgacacc 3836581 cgcctgtttc cacggaatca tgccggcaat gacaatgatt gaaagcacaa agaacacaag 3836641 cgttctccat actgtctgtt tgatggaccg cggaatcgtt ttttcagggt cttcactttc 3836701 tccggctgca accccgatca gctcagtccc ctgaaacgca aagttcacag taatcatcgt 3836761 aatcagcatt gcctttatgc cgttcggaaa taacccgtct tcataaaaat gtgtcaaaaa 3836821 cggcgcctgc tctccgccct tcagatcaat caggccaaac atggcagctc cgccgagaat 3836881 aataaataaa aggataatca aaattttaat gcctgagaac cagaattcag attccgcaaa 3836941 ggcttttgtg gtgatcgcat ttaaaataaa catcagtgcc gcaaagacca gacaccagat 3837001 ccacacgtct atatgcggaa accagcgttg catcagctgc cccgctgata aaaattcaat 3837061 ggcgcatgta accgcccagc cgagccagta cagccagccg aacgcaaacc cgaaggccgg 3837121 gctgataaat ttcgtggcat aggtctggaa ggaccccgac acaggaaagg cgactgccag 3837181 ctctcctaag cagagcatgg tcaaaaacat gataaagccg cccactaaat aggacagaac 3837241 cgcgccgagc ggtcccgctt ggttaatggt aaacccggtt ccaaggaaga aaccggttcc 3837301 gatcactccg cccaatgaaa tcatgaacaa atggcgtgat ttcattgtcc gctggagctg 3837361 atttccgtta tcttggtttg tattcacatt ctgcacccct tcagcaactt gtattggatc 3837421 taagctggaa catctgcatg gtgctatccc agtttgctgt ccaaagagtc tctatctatt 3837481 taatataaaa ttcacttctt ctcataaaga tacattatac taaaatactg tagctgagca 3837541 aatagggagt gctgattttt ctgttgtaaa tttatacaaa cgaagtgaat atcccgccat 3837601 ggtgcggatt tatgcgtttc gcagcacgtg cttaattttc tctatcgccc aatccaagtc 3837661 ctctttggaa atgattaatg gcggtgcaaa acgaatgact gtatcatgcg tttccttgca 3837721 taaaagtccc tcttccttca aacgctcaca atacggacgt gccgcttcag tcaattccac 3837781 accgataaac agccctctgc cgcggacttc tttaatgaca gggctgtcaa tactctcaag 3837841 ctcgctttta aagtattcac caagttcaag agaacgatcc gccagctttt catcctccag 3837901 cacttctaat gaagcgatag acactgcaca tgcaagcggg tttccaccaa atgttgagcc 3837961 gtgtgagcca gggttaaaca cgcctaggat ctcgcggtcc gccgcaatgc aagagatcgg 3838021 gaacacaccg ccgccaagcg ctttgcccaa gatatacata tccggaacaa tgccgtccca 3838081 gtcacaggca aacgtcttgc ctgtacgtcc gagacccgtc tgaatttcat ccgcaataaa 3838141 caagacattc tcttccttac aaatcgccgc cgcttcctgt aaaaatcctt caggcggaat 3838201 cacaatgccc gcttcgcctt gaatcggttc aaacaagaat gccgctgtat tcggcgtaat 3838261 ggcctgtcga agcgcttcca catcgccgta aggaatgagt ttgattcctg gaagcatcgg 3838321 gccgaatcct cgtttatatt cctcttcaga agaaagagat accgccagca tcgtgcggcc 3838381 gtggaagttc ccgacacatg cgataatttc cgcttgattg tcagctacgc ccttcacttc 3838441 atacgcccag cgtctcgccg ctttcaccgc ggattcaacc gcttcggctc ctgtattcat 3838501 cggcagaatc atctctttgc ctgtcagttt agctgttttt tcgtaaaacg gcccaagctg 3838561 atcgttatga aacgcgcgtg acgtgagggt gattttatca gcctgatcct ttaatgcctg 3838621 aatgattttc gggtgtctgt gcccctggtt taccgcagag taagcactca gcatatccat 3838681 atattcattg ccttccgggt cctttaccca agcacccagc gcttcagaaa taacaatcgg 3838741 gagcgggtga taattgttgg ctccgtaatg agacgtctga tcaataattt ctttggattt 3838801 agataaagct gtcatatttg aattccccct tgttttctgt ttcaacatgt tatcctgctt 3838861 tccctttata taaatgcaag ttctgtgcca aatcaagaat tcgtgtgttt tctacaattt 3838921 tcgaggacaa ggtgcaaaaa cattctgata tttcgagcga aaatttcagc aagtgcaaaa 3838981 ttcttttgca tatcctctcc gtttttttat aaaatagaag caatattaag aaaataattg 3839041 agggaggttc atacagtggt caaagacagc gaattcctca cattggtttt tcagagtatt 3839101 ttagatgaaa tcgatgttgg cctgcacgtg gtagacgagc atggaaacac aatcgtttat 3839161 aacaataaaa tgatgcagat tgaagatatg gagaagcatg acgtcttgaa taaaaacctg 3839221 atggatgtgt ttatgttttc aaagcagcag gacagcacac tggtacaggc tcttcaggaa 3839281 ggcaagacga ttaaaaacgt caaacagagc tatttcaata ataaaggcca ggaaattacg 3839341 acgatcaatc atacatatcc catcgtccaa gacggcaaaa tcaggggcgc cgttgaaatt 3839401 gccaaggatg tgacaaagct ggaacggctg atcagggaga atatgaacaa aaaaggcagc 3839461 acaacctata cgtttgacag tattctcggc accagtccgg ccattcaaga cgtcatcgaa 3839521 aacgccaagc gggcaacccg tacgtcatca tctgtccttc tagcaggcga aaccggcacg 3839581 ggaaaagaac tgttcgcgca aagtatccat aatggaagcg atcgttctgg cggcccgttt 3839641 atttcgcaaa actgcgcggc actgccagac agccttgtgg aaagcatttt gtttgggacg 3839701 aaaaaaggcg cgtttaccgg cgctgtcgac cagcccggcc tgtttgaaca agcccacggc 3839761 ggcacactgc tgttagatga aatcaactcg ctgaatctca gccttcaggc gaagctgctg 3839821 cgcgcccttc aagaacggaa aatcaggcgc atcggttcaa caaaggatac accgattgac 3839881 gtacgtatta ttgccacgat gaatgaagac ccaattgatg caattgcagg cgaacgaatg 3839941 cggaaggact tgtattacag gctgagtgtc gtcacactga tcatcccgcc gcttcgggaa 3840001 cgaaaagaag acattttgct tctcgcgtcg gagttcatcc agaaaaacaa ccatctgttc 3840061 caaatgaatg ttgaacacat cagcgatgac gtgaagcaat ttttcctttc ttatgactgg 3840121 ccgggaaata ttcgcgagct tgagcatatg atcgaaggcg caatgaattt catgacggac 3840181 gagcaaacga ttacggcttc ccatctgccc tatcaatacc gcatgaaaat caagccggct 3840241 gacatcccag agccggaaac accaagacac cagccagccg cggacttaaa agaaaaaatg 3840301 gaaagcttcg aaaaatatgt gatagagaac gtgttaagaa aacacggcca taacatctcg 3840361 aaagctgctc aggagcttgg catcagcaga caaagcctcc aatatcggct gaagaaattt 3840421 tctcactcgt ctaacgaata atccggagca ggaagcctga tcagaaaaac agtgcctctg 3840481 ccgatttcac ttttcacttc aatcgtccca ttgtgattgt cgataatcga tttcgttatg 3840541 gcaaggccta atcccgaacc tccatatttc cgggagcggg atgggtctgc cttgtaaaac 3840601 cggtcaaaca ctaaaaaacg tcacttctta tgcattgaag aaagaaaatg gcacctatgt 3840661 gtatcacagc cagcaaccac acggtacaaa ccattaaagt ccatgcaaat aacggaagta 3840721 tttgcagcta actgccattt gctgtttcac gtgtaacatc catcttgtat ttttcttcat 3840781 attcgatata tcctttttca actgaacggg cgtgacccct gttcagtttt ttttgcatat 3840841 caaaacagcc tggcaacgat gccagactgc ttttattaac tgcctaattg gtctgcggag 3840901 gacagcttga tatcaacaga tttttctttt ccgccgcgat aaaacttcac cttcacccgg 3840961 tcaccgactt ttttctgata aagccgtttt cgcaggtcaa caatatcatt tactttgtat 3841021 ccgtcaaatt ccgtgatgac atccagttcc ttcagccccg cttttccggc aggtgaaaag 3841081 gcgtctacac ccatcacaac cgctccattg gtgacgttct taggaagctt taatgtttca 3841141 tcccaatgat agcttgcgat gtcacttagc gatttcatct caatgccaag gaacgggcgt 3841201 ttgacctttc cgtatctctc taaatcctct atcacaggga tcacgagctt agacggaatg 3841261 gacaggccaa tcccttcaac cgctgactcg gcaattttca ttgaattgat gccaatgacc 3841321 ttcccatcca tatttaacaa agcgccgccg ctgttcccag ggttaatggc cgcatctgtt 3841381 tgcaggactt cagcgttcca gtcaggctgt ccatcaccgt ttgaatctac tgggatcgcc 3841441 ctctccgtac ccgagatgac gccttgtgtg acagagcctg caaactcaag gcctaacggg 3841501 ttcccgatcg caataaccgg ctccccagac ttcactttat ctgaatttcc gaaatcagcg 3841561 actgctttaa tcttatcgct tttcacccgt aaaacggcaa ggtccatcag ctggtcgctg 3841621 ccgacaagat cagctgatac acgtgagccg tctttcaagc tgatttcaat ttgggaagcg 3841681 ccttcgatga catgatggtt ggtcacgaca taagcggaat ggtcattttt cttatagatg 3841741 acgccagagc cgctcccagc ctcgccgctc tctccccaaa tatctgattt ttggatgttc 3841801 acaacaccga caacggcggg cgacatattg ctgacaatct tggtgacggc attgttgaca 3841861 ctgacattca ccgtcctgat tgattcccgg ccattgttgt tttgctgctg atctaaggcg 3841921 cctgtatcca gcccttcatt tgaaaggtac ggcatgataa acgccattaa tacggcaccg 3841981 acaatcacgc caatcagact cgaaagaaaa tatccttttt tgcttctctt tggctgttca 3842041 ggagtagtat gttcttcctc acgttcgtaa tccaccatat tccatccttt ccaagaacgt 3842101 taatatggtt atattgtggg ttagaaactc ctagaatagt catgatttac atagaaaaat 3842161 tatacagcgc aaagcggagt ggccttcttc ggatcggtgt cgtataagtc aaatgtctca 3842221 cccgtcacaa atcctttaga agccaatgtc tgctgcacag acattcttgc cagctccttc 3842281 atgttgttgt cctggctcaa atgcgccagg taaatacgag acgtctcatc gccaatgaca 3842341 tccgtcatcg ccaaggcagc atcttcattt gacacgtgcc cgacgtcact taaaatccgc 3842401 cgcttaatgc tccatgggta tcttcccatt tgcagcatac cgacatcgtg attgctttca 3842461 aacacaaata cattcgctga acggataatg cctttcatcc ggtcgctgac atatcccgta 3842521 tctgtcatta acgcgagctt tcggccgcta taatggaata cataaaacat cggttccgcc 3842581 gcatcgtggg aaacgccaaa cgattcaaca tcaagtccgc cgaacgactt caccgtctcc 3842641 attggaaata caaacttttg atcggtgtca attttgccga tttgattctc catcgctttc 3842701 caagtcttct cattcgcata gatcggaagc ttgtactttc tggcgacgac accaaggccc 3842761 ttaatatggt cactatgctc atgcgtcaca aaaatgccgt ctacatcatc cagcttacgc 3842821 ccgatctgcg ccatcagccc atccatggct tttccgctca aaccggcgtc cactaaaaat 3842881 gcgtgatcct ctgtttcgag gtaaaacgca tttcccgtac tcccgctcgc aagtacgcta 3842941 aattgcaagc tcatgtttgt ctcactccat tattttcatt gatctgtatc taaaatcgta 3843001 ctctccaaag cattcacagt aaaatactct tgtactgtct ttttctcacc gttcactttt 3843061 ttctcgtact cgaccgtaat tctccatacc ggcgccagca cctgcgtact tgtcagcgga 3843121 tattgtgcta catagccgaa tttacagctc ttcacagtgc tgtattcttt taattgattt 3843181 tgatagtaca atagctcaac cgcatccatt tcagtaatta agctttcttt ctggatttgc 3843241 ttgaaggtct caagcgtagt ctggtcgtat gacacaacct cgtttttacc gtttaagtgc 3843301 agcaccactt gcccgatcat attagaggga ttgtcggtct tttggtaaat ataatgacct 3843361 tcgtacgttt ggaagaaaat aatttctttc ttcgatttat caaccttcca aagcttatat 3843421 ttttcgccat cttgaatttt cgaagaaaca agtgcctgag catcgtcctc gatatccttc 3843481 tttgatagtg cgattggatt tgcaaacttc attttcaggc tcgttacttt atgatcatca 3843541 ctaggcatgt ccatcaaagg cttttgatcc ttcagcgcct caatttcctc cttggagaaa 3843601 gacttttgat ttgccgtgat ccgatagcct tctgttgctt ccttattcaa gccttcatac 3843661 gtgatatgat cggccttcat gtcatgctcg acatcatttt taatgacttc atattctttg 3843721 ccggtagcct gccatttttg aaaaaactga tagcctaaga aaatatctaa aatgaggaag 3843781 gcaacgatga agattgattt tgtcttattc cactccactg ttagccccct ccttcctcaa 3843841 taaatccttt gtaatcggca caatttttcc atttactttc atcgcccaaa ccggttccag 3843901 ttcaacgaga ggatcatcgt tggttgatgt tgataccaat tgataagcaa ggaagatctg 3843961 atcaattttg tccgtatcat aagcggtttg tttcgaaagc agcatcttca cttcgctgcc 3844021 gcccatgagc tctgtttcac ttgttttaat cggattcgtt ccgagactgt aattcggccg 3844081 cttatagctg agaatatcat cattcgccca ttgcaccgta atcgccgatg tcgccccgaa 3844141 aggtttggcg gtgctgttaa tgaccgggat ctgatccata aaaatataga agctcaactg 3844201 ctggctgtca ttgatattga aaaattgata gtgatccgtc cagcttccgg tatcctcaag 3844261 gtatttttgg ctctttttga ttaattcacc tgtttgatag gatgtgctct gcaccaaatt 3844321 gcgctgctga aattgcacct gtctctggct tagattcaca tctaaccggc tgatcccatc 3844381 tgtcagcaca tttctgttgt tgtaattcga atcttctctt acaatgctcg gatcactaaa 3844441 caaagcctgc ttaaaggtat ttgttttaat cgattctgtg acaaattctt ttttgtccat 3844501 cgtaagcggt ttgttcggca gcaagaactc tttctttgag ccaatggaga acaaactgaa 3844561 cgccggcata tttgattgcc tgtttttcaa gtcgttcata atgttccggt agtttgctga 3844621 ttcaaccgtc acttcaagaa tgagctgctt gctgtatgac accaaataga ttttcttgtt 3844681 cgcttttgtt tcattgaacg ggatcagaat atggtcaaac gaactgtatt caaacgactg 3844741 attagaccat ttaaacagcg tttggaaaat atcaatcggg atcgtatcgc tgaattgcaa 3844801 gtcaagcttg gcttcagaac cgcctattcc ataaaaccag cttttgaatc cagccttgtc 3844861 atactgatcc gaaatatctt taattccttt cacatcccaa tgcggcaagt cagaccaaat 3844921 ttcttcatag agggcattgt catccacttt gtaatgagcg ccgtcatcat ggataaacat 3844981 gtcccttggc cttaccgttt cagacagctt ttgggtggtt ttttcgattt tatgtttcac 3845041 acgaacagta gactctgttg aggatgagcc ttcagaaaag tttggctgga acgtccatat 3845101 cccccatgta aaaacaagac tgatgacgac gagtaccgta agtaatatcg tttttatatt 3845161 ttcacgcttc atcccaatca tcctcttgtt cctctttata tggaagagta aatgtaatcg 3845221 tcgtgccttt tccttctatg ctgtccgccc aaatatctcc accgtgcgcc tgtaccattt 3845281 ccttggcaat cgccaatccc agaccggtgc cgccaagctt tctcgttctc gctttatcca 3845341 ccctgtagaa gcggtcaaag actttttcga catctttttt cggaatgccg atcccttcat 3845401 ccttcacgct gatatagaga agttcttcct cttcattgac atcaatcgag aacgtgacat 3845461 gtccgccttc cggtgaatat tttaaagcgt tagaaataat attatcgagc acctgcgtta 3845521 ttttatcctg gtcaatctcg acatacagat ctctgtccgg cagattgcgg ataaactcca 3845581 catgctgctc ttttgtcatt tcaaaacggt caataataag tgacataaac cggacaatct 3845641 gaatccattc ccggttaaat tgataatctt tactgtcaaa tttcgacagc tgaagcagat 3845701 cattgacaag ccggatcata cgctctgttt cattttgcgt caccattaag aagcgcggag 3845761 caatgtcttt attttcccac gcgccttcag ctaacgcttc taaatagctg cgcattgtcg 3845821 taagcggcgt ccgcagctca tgtgatacat tcgcaacgaa ttctctgcgt tcctgatcca 3845881 ttttctcttg ttcggttaca tcgtaaatga cagcgattaa accatcaatt ttgccgtgtt 3845941 ccctttgaat cacagagaaa ttcacgcgaa gcaccgttaa ttcatcatcg cgctcaattt 3846001 caagcagcat agaatcctgc tgttccacta aatcttcaaa agtataattc tcttgaagcc 3846061 ccagcaaact cgtaatcggc atttctaagg ctgtttcacg tgaaacgttc aacagttcca 3846121 gcgccgggct gtttaagaga ataatcgctc cgtttcggtt tgtggcgata acgccgtctg 3846181 tcatataagc aatgacagag gctagctttc tgcgttctcc ttcagtcatc gcctgggcat 3846241 cttcaagctc tctcgttaag tggttaaacg ttgtggccag ctgcccaatt tcatcatgtc 3846301 catacttttt aaccttcctc gagaaattcc ctttcgcaag ctccatcgcc tgctttcgca 3846361 tatctgaaag cgggtgggta atggttcttg ccagaaaaat accgagaaga gccgtcaaaa 3846421 caagtgccaa acctgtgccg gacgccagta tcgtgttgat cgtcttcatt tgattaaaga 3846481 catcttccat actcgcgaca acgtagatcg cgcccacaac ctcttggttt tcagtcatga 3846541 cgggcttcgc ggaaataaga actctgattt tgcttttcgg gtcataatat tttcttaaat 3846601 acgactgttt ggtagaaaag attcttttga aaatcagatc ggtcgtttgt ttcccagcca 3846661 cttcctcacc gtacggcttt gaagaaccga ccacttcata gcttttatct acaaagctaa 3846721 tttcccgaac ctcatcactt ttcgtgaagt cattcaaaat acggctgacg tcatccttta 3846781 tgacggtact gtcgttatcg ctcttatatt cttgttcgat ataataagaa aggttgtcga 3846841 ttcgctgatt cagcgattgt tcataagagc tgatcagcga cttctctacc tgattgacaa 3846901 aatacacacc aatgatttgc atggcaatga taatcaaaag cacataaatc aaggtaatct 3846961 taaattggat cgaccgaaaa aaaccaacct tattcatatg ggcattagtc ctgttctggg 3847021 tttctcaagt aataacctac accacggcgt gtgacgatcc aatttggatg gctcgggttg 3847081 tcctcgattt tttcacgaag ccggcggact gttacgtcaa ccgttctgac atcgccgaag 3847141 taatcatagc cccaaacggt ttgaagcaaa tgttcacggg tcatcacttg tccgatatgt 3847201 tttgctaaat aatgaagcaa ttcgaactca cgatgagtca attcgattgt ttcgtctcgt 3847261 tttgatacaa cgtacgcgtc agggaagatg acgagagagc cgatatgaat ctcgttagag 3847321 gaaggctctt cctccgcagg cgctgttgtc agctggcggc gcaggttcgc ttttacacgc 3847381 gccaagagct cgcgtgtgct gaatggtttt gtgacatagt catcagcacc gatttcaagc 3847441 ccgataacct tgtcaatttc tgaatcctta gccgtcagca taatgattgg catatcgtat 3847501 ttctttctga cttcgcggca tacttcaacg ccgtctttat ttgggagcat aatatctaaa 3847561 agaattaaat caggctgaag ctcttctacc atttcaacgg cttcgtttcc gtcgtgggca 3847621 cagtgcactt catagccttc ttttcttaag ttaaattcca atatatctgc aatcggtttt 3847681 tcatcatcta ctacaaggat ctttttatcc atcattttga ttttcctcct gccgaatgac 3847741 ttcatttcat ctatataaca ttcgtttcat cacttatggc ccatgtaaag aatgggtcct 3847801 tgtctattat aacggtttaa ggtcaaaaga taaaaaaaat aaaggtttag aaaaaaaaca 3847861 catgtttcac ctttatcgcc agttgtttat ctattgtcat gctggtcaac tttttttaaa 3847921 aaagataact ttattgaaac ctcccctcac cggagtgcgt ctttatcaat gacgtcttct 3847981 tctttgaacc ggccgcaggg ccggttctcc ctttttcttc tattataaca ctcctcatgt 3848041 ttgccttttt cctaaaagaa aaaacgcacc tacgattgca gatgcgtttg gtaagtggct 3848101 cgggacggaa tcgaaccgcc gacacacgga ttttcagtcc gttgctctac caactgagct 3848161 accgagccaa atgttttatt tttctctact aagtaaagta aaatggcggt ccggacggga 3848221 ctcgaacccg cgacctcctg cgtgacaggc aggcattcta accaactgaa ctaccggacc 3848281 ttacagtaat tgcccggaga gctgtcgtgt cagctctcac agacaaataa ggaatttagc 3848341 aataacgcta aagtaaatca atgacccgta cgggattcga acccgtgtta ccgccgtgaa 3848401 agggcggtgt cttaaccgct tgaccaacgg gccttcacga aatggtgagc catgaaggac 3848461 tcgaaccttc gaccctctga ttaaaagtca gatgctctac caactgagct aatggctctt 3848521 aaagatgtcg gaatttctat agagcaaacg acttaaatct agttctcatc ttgtactcta 3848581 ttgaagcagt ttccgtaaca acgagattta taatatcacg aacaaataga agtggcaata 3848641 acttttttgg ttttttttca tatttttttc tcagaccaac ttatatgcgg ctttcaaaca 3848701 aaaacaagcc ccttaaatag gggcttgcag acatattcta tttagttcgc acggtacaca 3848761 ctgcgaagga catttgtttg tgagcggtct ggaccgacag agaaaataga aagcggaatg 3848821 cctgtcagct gagacacacg ctcaagataa tggcgcgcat tttccggaag ctcgctcaag 3848881 ctcttcgcac ctgtaatatc ctcagtccag cccggcattt cttcatatac cggctcacat 3848941 tcagcaagtg ccttaagact tgctgggaat tcttcaatga tttcgccttt gtagcggtac 3849001 gccacacaga ttttcaacgt ttcaattcct gctaggacgt caattgagtt cagagaaaga 3849061 tctgtaattc cgctcacacg gcgggcgtgg cggacaacaa cgctgtcaaa ccagccgaca 3849121 cggcgcgggc ggcctgttgt tgttccatat tcgcgtccga cttcacggat ttgatcgccg 3849181 atttcatctt tcagctcagt cggaaaagga ccgtcgccga cacgagtcgt atatgctttt 3849241 gatacaccga caacgtgctt gattttggtc gggccgacac cagaaccgat cgtgacaccg 3849301 ccggcaaccg ggttagatga cgtaacaaac gggtatgttc cttggtcgat atcgagcata 3849361 accccttgtg cgccttcaaa taatacacgg cgcccttcat caagagcatc gtttaagaca 3849421 acagatgtat cgcaaacata ctttttaatc tgctgtccgt actcataata ttcgtctaag 3849481 atatcctcaa gtttaaaccc ttctgtctcg tacattttct cgagaagacg gtttttttct 3849541 tcaagattgc gctcaagctt ttccgcaaac gcgtcacggt ctaacagatc cgcgatgcga 3849601 attccgatgc gggctgcttt atccatgtaa gcagggccga ttcctttttt cgttgtgccg 3849661 atcttgttag cccctttacg ctcttcttcc acttcatcca atttcaaatg atacggcaga 3849721 atgacgtgag ctctgttgct gattctcagg ttatctgtac tcacgttgcg ctcatgaaga 3849781 tacgcaagct ctgtgactaa tgctttcgga tctacaacca ttccgtttcc gattacacac 3849841 gttttatcct tatagaaaat tccagacggg attaagtgaa gcttatatgt gattccgtca 3849901 aacttgattg tatgccctgc gttatttccg ccttgataac gggcgatcac ttctgcattt 3849961 tctgatagga aatctgtaat tttacctttt ccttcatcgc cccattgcgt acctactaca 3850021 actactgaag acatgtccgt gcacctccgt taacctttca aaacgattct attcaaacaa 3850081 atcaagttta tcagtgaaga aacagaaagt caattgtaaa tccgaacatt aatttattgt 3850141 aaatctatat tcgttcgctt ccattcgttt tataagcgtt ttctcactgc tttgtcataa 3850201 aaagcttgcg aaactttcat cctttagcat aagaaagaat cacttgcctg atatcccttt 3850261 tgaattcata aaaacgatcc gccagccgtc cgggtcctct atcgtcacgc ccccattgct 3850321 ccagtacggg ttctctgatt cgacctcttg atagcccatg tgctttagct ttgaagtgat 3850381 cgctgccagt tcaactgcat tcggcacata aaaaacaaga aggctgtcgg gatggggaac 3850441 gggggcagtg cttccccctt catactgggt gaattccaaa tgataatcgg catgaggaag 3850501 gccgaacatg acaccgtcat acccgttatg ctgtgaaaat tctcctattc gtttcaaaca 3850561 cagtccctct tcgtaaaaac gaataatctc atcaagctgg cccgtaggac gcgcaattcg 3850621 gatttgtgct gcttgaaaag acgaaaaacg ttttcccata ttgttaccat ctcctttttg 3850681 caccatttta ttaaaacgct ttcaattttt catccgctga gcgaacgtca tttcttccat 3850741 ctttcgaatg aaaaaaaccc caagagcagc tcttggggct tatgcgccgg gcggaacgcc 3850801 tgcgtcatca aaacgccgtt ccaggttgac gaatttgttg tattctttta cgaacgcaag 3850861 agacacggtt cctaccgggc cgttacgctg tttggcgata ataatttcga taatattttt 3850921 attctcggtt tctttgtcat agtagtcatc acgataaagg aacgcgacaa tatccgcgtc 3850981 ctgctcgata cttcctgatt cccggatatc agacatcatc ggacgtttat cctgacgctg 3851041 ctcaacaccc ctggaaagct gagaaagcgc gataacaggg acttgcagct ccctcgcaat 3851101 cgacttcagt tcacgggaaa tttcagatac ttcctgctga cggttgtcct ttgaacgacc 3851161 gcttccctga atcaattgca ggtaatcgat caaaatcatg cccagcccgc tttcctgctt 3851221 caagcggcgg cacttggcac ggatttcact cactcgaata cccggtgtat catcgatgta 3851281 aatcccgctg ttcgataggc ttcccattgc catcgtcagc ttgccccaat cctcttcggt 3851341 caggttacct gtacggagat tctgggcatt gatatttccc tcggcacaga gcatacgcat 3851401 aacgagctgc tcggcaccca tctcaagact gaaaatcgct acgctctcat cggtcttcgt 3851461 cgccacgttt tgtgcgatgt tcagggcaaa ggctgttttc cctactgaag gacgggcagc 3851521 cacaatgatc aagtcgttgc gctggaaacc cgcagtcatc cggtcaagct ccgtaaaccc 3851581 tgttggaatt cccgtgatat caccttttcg attgtgaagc tgttcgatat tatcataggt 3851641 ctggacaagg acgtccttaa tattttggaa ggcactcgtg tttttgcgct gtgccacttc 3851701 cataatcgtt ttttccgctt cactgagtaa atcctcgacc tcatcctcac gggtataccc 3851761 gtcttgagca atcgttgtcg cagttctgat taatcggcga agaatcgatt tttcctcaac 3851821 gattttcgcg taatattcta tgttagccgc tgtcggcacc gagtttgcga tatctgtcaa 3851881 atatgaaata ccgcctactt cttccagcag gtctgtgttc gcaagctctg atgtaactgt 3851941 caccagatca accggttcac ctcggtcacc gagcaccagc atcgcattat agattttttg 3852001 gtgggacatt ctatagaaat catctggaat caatacttct gaagccagtg ttaaagcaga 3852061 cggctgtaaa aaaatagcgc ctaacacggc ttgttcggct tctatatttt gcggaggaag 3852121 ccggtcattc agaaggtctg tcatgctaag caccgtcctc tcattaaaaa atctccaacc 3852181 tccattctac catttctaca gaaaaaaaat agaaaaattg tctgtttcct gtttttttca 3852241 gttagcagat tggatcgttt cggacagtaa caaggcggga aaaatgcaat aaaacataag 3852301 ggaggaatga aagatgataa agaaatatgc gattacacct aatgttgatg cggacggctg 3852361 gtttattgag gtggagaatg tagcgccgac agctttgtat acgtctaaag acgccgctat 3852421 tgaaaaggcc aaacaggtgg ctaaggaaaa cagtccgtct aagcttgtaa tttatgacca 3852481 gtttaaaaat gtggaagaag aacactcatt ttaatgaatg aaagccttcg ctgcagcgag 3852541 ggttttttag cggttatcgg tttatttcat ccattggatg cctatgtgca tcatcaaatc 3852601 tgccgctttt tgatacagat cccactcccc gatcgaagca aatttcccca tcagctcctg 3852661 aagctttaac ctcattgcta tatattcttc gaaagtgaca gctttttcag tgtctatttg 3852721 gtgttccttc agcatttgtt ttaataagga taacggtgcg tgcataagaa ccctccttac 3852781 ctcttttata acggtcattt tccgattgct ctattccttt gtgacatctt cttacatttc 3852841 acatctgatt cttgtacaat ggacagaaga gaggagggat cttttgtgag acctttgcaa 3852901 atttctgccg aaactgcaca aaagcttgca gagtccttga atctgccgct tgaacagatc 3852961 atgcatatgc ctcagcatat tctgcttgcc aaaatggctg aactgcaaaa agaggacaaa 3853021 tcatagcctt cattcacata cttgcttacc tgtttcggga taatatcatg tatatgttag 3853081 aaaagaggag taactgcttt gccacatcca cataataaaa aaatccaatc attttggctg 3853141 atcaccggca ttatctttat cgcctttaac ttacggcccg cgatcacttc agtcggtccg 3853201 gtcatcagct ctatccgggc agagctgcac atgtccaatg gggcagccgg ttttttgacc 3853261 gcactgccgc tgctttcgtt tgcagttctt tctccgcttg cacctaagct tggacagcgc 3853321 ctcggtaatg agcgaacttt atggctaggt ctcgtgatac tgctgatcgg tgttctgact 3853381 cgttctaccg gctatactgc cgctttgttt ttcggaacag cacttatcgg cgtcgggatt 3853441 gcgattggta acgtactttt gccaagctta atcaaacata aataccctga aaagccaggg 3853501 atcatgatca gcctgtatac gacatcaatg aatatattcg cagctttagc atcgggtgtc 3853561 agcgttcctt tagcgaccca gatgaatggc ggatggaaac aagcctttct cttatggggc 3853621 gggctggctt tacttgcatt gctaatctgg atacctcagc tgcgccatcg agatacggca 3853681 aaccagacaa tgaagctgca atccagttcc atttgggctt ccaaaatggc atggtatgtc 3853741 accatcttta tgggcctgca atcgttttta ttttacagca gcatcgcttg gtttcctgaa 3853801 attctccgtt cacacgggat tgatacggca acagccggat ggatggtatc actcatgcaa 3853861 tttgcgagtc tgccttccac ttttctgacg ccagttttag ctgaccgtgt gaaacagcag 3853921 cgcggtatcg ttgcggcgct ggcctcagtt tatctgatcg gcctttgcgg attattagcg 3853981 ggcggaagcc atacattgct tgccatctgg atgatcatta tcggtatcgg acaaggctcc 3854041 agcattagtc tggcccttac tttgattggt ctccgcagtg aaaatgccca acaggccgct 3854101 gcgctgtcag gcatgtctca gtcattcggc tacctgctgg cagcagtcgg gccaatcttt 3854161 gtcggctatc tctttgacca gacgcattct tggacgatgc cgattgtgct tctcattgct 3854221 gccctgatcg taatgggagc agccggacag ggagccggac gagatcgata cattttccag 3854281 tcagaaaaac aaagaaattc agcataaagc ggggaagata tctccgcttt tttctttgaa 3854341 tatttatggt ttattcataa gtttttcata tttgtttttt acaatgagac accataaaga 3854401 ggtgaaaaac gatgaaaacc aaacgattcg acgcagccct tattcttatt ttgctagcag 3854461 cagctttttt gaatacgtat cacatttggc aggatgatac agcaaaccag tactatttgg 3854521 cggctgtaaa aagcatgacg caaagcttcc ataacttttt ttatgcgtca tttgaccctt 3854581 ctggatttgt gacagtagat aagcctcctg tcgtgttatg gattcaaacg attttcgcac 3854641 tgattttcgg tgttcacacg tggagtgtca tcattcccca ggctcttgcc ggagttggat 3854701 ctgtcttcct tctctacaga atggttaagc cgacttttgg agttggagcg gcccgcattg 3854761 ccgcacttgt catggcactg acccctatcg cagtagctgt cagccggaca aacaatatcg 3854821 acagcatgct tgtttttacc ttattgctcg gttcaacttg tctgcttagg gcagtaaaac 3854881 aaggcaagct ggtttggctg ctgacggcat ttgccctgat tgggctcgcc tttaatatga 3854941 agatgatgca agcgtttatg gtattgcctg catttgtgtt attctacctg attgcatctc 3855001 gggtttctct gaagaaaaaa atcgggtccc tgcttctgtc tcttgtcctt ctgacaggcc 3855061 tttcactctc atgggcgatt gcagtggatt cagcctcttc ctcaagccgg ccttatgtag 3855121 gaagcagcca gactaactca gtgctagaac tggcctttgg ctacaacggc acagagcgtc 3855181 tgtttgggca aactacgggc cttgcaaagg gtgatatgaa tgctgctggc ggagggaaca 3855241 tgcagaatca agacaacatg caagcgccaa atggcaacgg ttcatctttt tctcagaacg 3855301 gtaatcaatc attcggaaac cattcacagg cgcctcagcc gcctaacgga caaaccggcg 3855361 ctctcaatgg aggcggaggc acacctccca caggtggcaa cggacctgga aatggagggc 3855421 ctggcggcgg aggcggaaaa agcgtgaata tgttcggcac cggtgatcct ggaccgcttc 3855481 gtctcttcca atcagcactt tccggccaaa tcagctggat gcttccattc tcattgatcg 3855541 gattactggg cgcaatcatc agctggtacc gtgatcgccg cggacatgct gctaaaatga 3855601 aagaaacgct attctgggcg gcttggcttg ttcccgtggc tggtttcttc agcatcgcag 3855661 gattcttcca ccagtattat ttgattatgc tggcaccgcc gattgccgcc ctttctggta 3855721 tcggatggta tacgatgcac cgcttataca aaaataataa agactggtcc agctatcttc 3855781 tgccggcagc cgtcttgatc acagccgtgt ttcaggtgta tattctgagc gcttatacaa 3855841 gccaaatcgg cagtgtatgg atgtatgtcc tggggctctt aggactgggc atcacccttg 3855901 cacttctgat gcttaaacgc agccatccgt tcagtaagct gctgaccatc atcagcttgt 3855961 gcgttctgct tctcacacca gtttactggt cagcaacgcc gcttctatac ggtggcaaca 3856021 gcgtccttcc tgaatccggc ccgcagctca aaggctcagc aaacggcggg aacatgttct 3856081 cttcagaggt cgacagcggg ctcctgtcct atctgagaaa acacaatacc ggcgaagagt 3856141 atttatttgc tactttgaca accgtaacag ctgcgccata catcatttac gaaaatgaat 3856201 ctgttatggc aatgggcggg tttaacggca cggatcccat tctgactgtg tcggaactga 3856261 aaaaactgat caaagaaggc aaagtgaaat acttccttct gtcagaaaac aactcaggca 3856321 acagcgaact tgtttcctgg attaagaaaa acggaaaaga aataacatct gacgagtaca 3856381 gcggttcctc cagcagcaca aacagcgtgc agggaatgcg aagaggacct ggcggagaaa 3856441 gccagcaaac tctttatctc gtggaataaa aaaagaggct tggatgaatc caagcctctt 3856501 ttctattaag cttcttcttt tacatgtacc tttaacacag cctgcacttc aggatgcagc 3856561 ttcacaggca cgtttgtata tcctaatgca cgaatgccgt ccggcagttc aagcttccgc 3856621 ttatctactt taatgttatg gtctttttgg agctgttcag tgatttgctt gcttgtcact 3856681 gaaccaaata aacggccgcc ctcacctgat tttgcgctaa gctcaacagt cagtttttct 3856741 aatgtctctt tcaagctctt agcctgctca agctcagcaa tggcttcttt tttctctttc 3856801 tgcttttgtc cgtttaacgc gctgatgttt gacgcgttcg cttcaaccgc gaggcctttt 3856861 ttaattagaa agttatgcgc ataaccgtct gctacgtttt tgacttcgcc tttttttcct 3856921 tttcctttta catcttgtaa gaaaataacc ttcatctctg tacgcctccc tcaaaatact 3856981 catctatggc gtgcttcagc cgttccagcg cttcagaaac tgaaatgccg gacaactgag 3857041 tcgccgcatt tgttaaatgc cctccgcctt ccagggcctc catgatgatc tgaacattta 3857101 cctcgccaag cgaccgagca ctgatacaaa ccgtttgttc atcccgtctc gccaccgcaa 3857161 atgaagcctc aacctcactc atcgatagca gcgaatcggc agcctgcgca atcagcactt 3857221 gatcgaagta ttcctcttca ttttcaggaa gagaagcaat cgcaatgtta tctttataga 3857281 ggaccgtatg ctggatcagc ttcgcccgtt taatatagga atcaacggtt tctttcagaa 3857341 acttctgcac cagcaccgtg tcggcgcctt ttgcccttaa ataagaagcc gcatcgaaag 3857401 tccgcgagcc cgtgcggaga gaaaagctct ttgtatccac tattatacca gctaataggg 3857461 ctgttgcttc aatcatattg atttttaagc gcttcggctg atattcaagc agctctgtca 3857521 ccaattccgc tgtggaagaa gcgtatggtt ccatataaac gagcagcgga tctctgataa 3857581 actcctcacc tcttcggtga tggtcgatga ccacgatatg ttcaatttta ttgaccagcc 3857641 gttcctccat gacgagtgac ggcttatgtg tatcaacgat cacaagcagt gtgtcatcat 3857701 tggaaatctc cattgcttct tcaggcgtaa taaatcttga ccacagttct tcatattttt 3857761 tgatttcccc aatcaaacgc tgcacacttg atccgatttg gtttgggtca atcacgataa 3857821 aaccatcttt gttatttgcc tgagccacct ttaaaatccc gatcgctgcg ccgatagaat 3857881 ccatgtcggg gaatttatgc cccatgataa tcacattgct gctttcggtg acgatttcct 3857941 ttaaggcgtg agaaatcacg cgggcccgca cccttgttcg tttctccatt gggtttgttt 3858001 taccgccgta aaacttcacc ttgccgtttg gcagcttaat ggctacctgg tctccgccgc 3858061 gtcccagtgc taagtccaag ctggattgcg ccaaatcgcc aagttctttc agggaagaga 3858121 ctgaagcccc gacaccgacg cttaacgtca gcgctacacc gtcaaacgag gttttttccc 3858181 gcacttcatc aagaatcgaa aacttcgaat tttcgagttc agttaagata tgttcattaa 3858241 gtacagcaat aaagcgttct gaagacgtcc ttttcaagaa gatcccgtac tcctgcgccc 3858301 aagcgttcag caaagatgtc acctggctgt tcatcgtgct tctcgtctgg tcatccaatc 3858361 cttgtgtcac atcatcatag ttatcaagga aaatatatgc caggacggtt ctttcgtttt 3858421 catatagctt ttcaatctgg atttgttctg ttacatcaaa gaaatataag agacgctcat 3858481 cccgtttgat gacaacccta aacttgcggt cattcaatgt aaccgtttcc gattccacct 3858541 cttgtttgat aagcggcact accgattcac aagtatcgta aagtgatctc cccactaaag 3858601 tgctttcatt aaaacaagag gaaagaaacg gatttgccca ttctatataa tattggtcat 3858661 taaaaagcat gattccaatc ggcatttcca tcaatgcctc ttcaccgact tttttcaacc 3858721 tgtaggacaa cgtagaaata taagcatcaa tctcttgtcg aataagagaa tcagcacgct 3858781 taataaaaaa caaaataact gccagcagca gcacttcgac ggttcctaat atccagttaa 3858841 aataaaagct gatgaggatt gtaataattg acagagcaat caatgcatag atgggatacc 3858901 gaaacagcgg tttttcataa aagcttggca tttctatcac tccccaccat gtgagtaaaa 3858961 ctcatgttca cttcacctta ttccttatat gaaagcccat atctaaaacg cctaaaatgc 3859021 gaatggccgc catgaagacc ggatgcacaa acccaagtat gacagcaatc acagccgcag 3859081 cctttggata ttgtttctta tggcaataga aaaagataaa tgataaacct tggatgaaaa 3859141 tcagaaaccc gagtataaac tccccattta aagcgataga gtacagcatt tggccttttt 3859201 ctaaaggcaa aaatgaaagc atgacaataa tcaaatacag tactacaaca ctttgcggaa 3859261 acttcaactc tctaaaaggc tttagattag gaatatcggg ggagaatcgc cttaagagcg 3859321 gcttagcgat aaggtaactg aggaaagaaa aaataactcc taccatcaca atagctgttg 3859381 gaaaaagata ttgaacgata cccaattgtt cttccatcag ttttaattgc ttctcaaact 3859441 gcccagcatt gcccgactgc ttcgctacag tttctacaat atcaagagat tgccggtatt 3859501 gtgtcattgc ctcatcaatg atattgatac ccaaaaactg aatgcttatc acaaaataga 3859561 agacaatact aagcatataa ataagagcgc ccgaaataat ggcgtgcccg ggctctttcc 3859621 ttttgaaaaa atgtcccatg gcaatgccgg cgcaagctga cataaaagct acaataagcc 3859681 cgttaaagga cccgacaata aaaacaaccg gaagactgac agcgcccatc catatcccta 3859741 gcttcaatcc atgtctgatc gtatacaaga tcattggcag cggcagtgca aataacagaa 3859801 ttgttccaat cacaggaaca taaacgacca gaagcgtaat gatcgcaaac agactgatta 3859861 aaatagcacc ttccattaaa gctctcgttt gtttcactta gtcacctcgt atcatcctga 3859921 acatacgaat agaaaagagc agcataaacg actgctcttt tgttcatcgc tgcaacatgc 3859981 tttgcaccga atgtttttat atcatctcta aattttactt ttatatttta acataagtcc 3860041 aaatcgcaag taaaatgacg ctaatgtttc atgtgaaaca tgaaaaagga aaagacattc 3860101 tttgaaaaga atgcccatca caattaatgt ttatcatcca taaagccaga agattccttg 3860161 tttttctttt tcgtttttct gacatacata aaaattaaga tcaccagtaa aagggttgtt 3860221 gcttgcagaa cgccgctgct aaacaagaaa aagttcttta tcatgtccca cattgtgttt 3860281 cacctctttg tgcatgttct caacccgtat cctatataag gtgaatttcc ctttttaaaa 3860341 acttcaaaac atcatgaaca acattgagcg ttgggcatat gctgatatgg aatctgatcg 3860401 ataaaggaga attttcacat ggatgaacgc agaacattgg cttggcatga aacattagaa 3860461 atgcacgagc tggttgcttt tcaatcaaac ggactcatta aactgaagaa aatgataaga 3860521 gaagtaaaag accctcagct cagacagctt tataacgtgt ctattcaggg tgttgagcaa 3860581 aatttgagag agcttcttcc gttctttcca caggctccgc acagagagga tgaggaagaa 3860641 gaacgcgcag ataacccatt ttacagcggt gacctgctcg gttttgccaa aacatctgtc 3860701 cgcagctatg ccatcgcaat tacagaaaca gcaacacctc aattaagaaa cgtactggtc 3860761 aaacagctga atgctgccat ccagctgcac gcccaagttt atcgatacat gtatcagcat 3860821 ggatattatc cgtcttacaa cctttctgaa ctgttgaaaa acgatgtcag aaacgccaac 3860881 agagccattt caatgaaata aaacaagcag caaaggagtt ccctttgctg ctatttctgc 3860941 tgatccttca ctaagccgtt cgaacgataa gattccagca cgtctctgtt ggattctccc 3861001 cattctttca tttgcaaaac aatcggttca agcgtgcgcc caaattccgt cagagagtac 3861061 tctaccttgg gcggcacctg gtgataaacc tcacggtgca cgatgccgtc cgcttccagc 3861121 tccctcagct ggagagtaag cattctttga gtaatactcg ggcagattcg ccgaaactca 3861181 ttaaatcgtt tcttgccatc tatcatgtga taaaaaagaa ttcctttcca ctttccgcca 3861241 atgacatcta gagtgaattc aactggacag ccttctttgt tcgggtatat attctttttt 3861301 tcactcattc ttgaccctcc aatagtacct tttttgatac tacattacat tttgcaacta 3861361 atctacccag tattttacac accttttctc cttagctcaa agaaaatgct tcttattcac 3861421 atcaattttt aagggtttgc atgattacac ctgcagcaag acgtgttaaa ctatataaag 3861481 attacactac ttaaaaaagg ataggagcta tcatggaaaa gatacttatt ttcggacacc 3861541 aaaacccaga tacagatacg atttgttctg cgattgctta tgctgatttg aaaaacaaac 3861601 tcggcttcaa tgctgagcct gtccgcctcg gacaagtcaa cggcgaaaca caatacgcgc 3861661 ttgactattt caaacaagaa agcccgcgtc ttgttgaaac agctgcaaac gaagtaaacg 3861721 gcgttatcct ggttgaccat aacgaacgcc agcaaagcat caaagacatt gaagaggttc 3861781 aggttttaga ggttatcgac catcaccgca tcgctaactt tgaaacagct gagccgcttt 3861841 actatcgtgc tgagcctgta ggctgtacgg ctaccatctt aaacaaaatg tacaaagaga 3861901 ataacgtgaa aatcgagaaa gaaattgccg gccttatgct gtctgcgatc atttctgatt 3861961 ccctgttatt taaatctcca acttgcacgg accaagacgt agcagcagca aaagagcttg 3862021 cggagatcgc tggagtagat gctgaagaat acggcttgaa catgttgaaa gcaggcgctg 3862081 atctaagcaa aaaaacagtg gaagagctca tttctcttga tgcgaaagaa tttacactcg 3862141 gcagcaagaa agtcgaaatc gcacaagtaa acacagtgga cattgaagat gtaaaaaaac 3862201 gccaagctga attagaagct gtgatctcaa aagttgtggc tgagaagaat cttgatctgt 3862261 tccttctcgt tatcacagat atcttagaaa atgattcact tgctcttgca atcggtaacg 3862321 aagcagcgaa agtggaaaaa gcgttcaacg ttacattaga aaacaacaca gccctcttaa 3862381 aaggcgttgt ttcccgtaaa aaacaagtcg ttcctgtctt aacagacgca atggctgaat 3862441 aagcaaaaag catcccgcgt cgggatgctt tttcttattc acccagcttc tcaatttgtc 3862501 ccatcacatc agtaatttgc tttgcgtttt ggaccaggtc tgactgctcc aattctttaa 3862561 gcgatacctt gccttcctcg gcttgtttca acacatcttc agcgcttttc tgcaaggttt 3862621 cgttatgctc ctgaatggtt cgatgaatct ccgctgcggc atcaggcggc gttaattcat 3862681 taaaatcagc ggcagccttc tgaatcgact caagctgcgc ttcaagtttt tctttcgcct 3862741 cggtgtcatt tacagctttc tcagccaatt caggcgcttc ctctgcaaat gtcttcacct 3862801 tctccacata accagctgct tcactcgtat agttcaatcc gtcgttcacc tgatcaagca 3862861 tgccgcatcc gcctgcactc aaaagtccca ctccggcaag tactgtcaaa atgatcttca 3862921 tcttcagccc cctcatcgtt tctttttcat tttttctttt aagatcggaa tcaatttctc 3862981 tttcgctaac ggcagccctt tcctcaccaa ttcacgcttc agccactttt tcagcttaga 3863041 cattctgatg ctcctctccc tttttgataa aaatgaaaaa actccaccaa tttggtgaag 3863101 ttcctgaaac aaaaagacct tcaccaaatc agatttggca aaggtctcgc taacaatgag 3863161 attgccagca aagccgagga caccttgtcc cgtaatgacg actttactgt gaaagctact 3863221 cccctttgga gtgttcattt ttattacttt cattctaaag caccgatctg ttccagtcaa 3863281 attcctgccg tttatataaa agcgcgctgt ggtatttaaa atttgaatgg tttttctatc 3863341 aggagatcat gctatgacag aggaggtttt catcatgagt caagagcgcg tgaaacggcc 3863401 tgggcatacc agatggtaca tatcttcgtt acttagcggc attattattc ttaattattt 3863461 tgaccgagtg gccatctcgg tagcggcccc tgcgatacaa gattcgtttc accttactgc 3863521 aactgaactc ggcatcgtgt tttccattta cacctattcc tatacactga tgcagctgcc 3863581 tgtcggaagt ttgctggacc gttttggggt cgcatgggtc acgagggttg gaatgacaat 3863641 atggagcttt ttaacgatcc ttcttgcttt tttgcaagga aaattgctgt tgtatctgtt 3863701 ccggtttctc attgggctga cgagcgcctc tgcgttccct gctgcctcta aagcaaccgc 3863761 tctctggttt cctccaagtg agcggggatt ggcaaactca ctgttcgatt cggccgccaa 3863821 gttttcaaat gtaatcggcg cgccattggt cgcctttctt gtcacaacat ttgactggcg 3863881 tgtcgctttt ttgacgattg gatgcatcaa tgtgctgttt acgatctttt tctggcagta 3863941 ttatgaacag cctgaacggc acaaacgcat ttctaaaagt gaactaaact atattcaaaa 3864001 acacaatgcc attacaacag agcaaatccc ttacaaaacg ggcccgcttt taaaaaagct 3864061 tttcaccaat cgaaaagtat ggggcttaat gatcggattt acagggtacg ggtatacatt 3864121 caacctgctg ctcacctggc ttccgacttt ctttaaacat acatacggta tggatctcat 3864181 gtcgtccggt ttatttacgg cagtgccgtg gctgatctca accatttccg gaattgccgt 3864241 cggcggctgg ctcgtcgatt attttattaa gaaaggctat cctaatacca aggtgtaccg 3864301 aaccgtaatc atagtcggaa tgagctttgg ctttttcttt ttaggatcca ttctgacgaa 3864361 caatattacc gtagccatta tttgcatttc catcggactc gccggaattt ccgcaaccgc 3864421 tccggtcggc tggtccatct ccgcagaact cgcgccgatc ggttccgtat ccatgctgag 3864481 ctccatggtg aatctcgcaa acaacctgtt cggaggcatt attgctgcgt cactgacagg 3864541 gtatttgttt gatgtgacag gctcctttac cctcagcttt ctggtagctg gttttgtgct 3864601 gttgctggga ttggtttttt atgtgtttgt attaggggat gtaaaacgaa ttaaactata 3864661 gaacatgaaa aagagagctg ccagttggca gctctccctt tacatcaaag aatcggcccg 3864721 tccccattta ccttctcctc gtcctgttcc tctatatcaa gccccgaagc tagcatttcc 3864781 tgctctatct gttcgagcac ctgctcgttt tttccttgaa gaccaccttc ataatgaaaa 3864841 gcatcctgtg tgccgttttc ctctattgtc gctaaaatat cgtggatatc attatggtct 3864901 cctgaaatgg agccgaatcc ctggttttgt tttttataat tcacaaaacc gctggggagg 3864961 ttgtttccga ggtttacaca tgatgcgctc cgagtagtaa ttcatcagtg tatcaaaatc 3865021 ttcattttgg attgccacat cacatgcaga gatgatgtct ttcaattgct gttccaaatg 3865081 aattccccta atcatcatga ttggatatat tatacaatgt ttgacacgta gggatccttt 3865141 tcatttttgt ttttacggtt tcgctggtcc atttccgcag agctggcgcc gatcggttcc 3865201 gtatccatgc tgagctccat ggtaaatctg gcaaacaacc tgttcgaagg cattattgcg 3865261 gcttcattga cggggtattt tgtttgatgt gacaaggctc ctttacgctc agctttctgg 3865321 tagccagttt tgttctgctg cttggattgg ttttttacgt gtttgtctta ggggatgtaa 3865381 aacgaattaa gcgggaataa agagtgcttg tagagaaaac gttgttcttt ctacaagctt 3865441 tttagttttg tgctgttttt caagatattc agctgtcata aaaagaaaat gagctcccac 3865501 ataccggcta ggtatgtggc gttcttcttc atgttctggc atgcagctgt gaggaggatt 3865561 tgtttgctca ccccctgaac ctgcgatagc taagcccgtg cagttgtttt gaacctacaa 3865621 agcttcgttc tattttttct tttctttttt tagagatttc ctgaaataga aaagcaatct 3865681 tttctaacct tttctttatg gttttgccat acataccgag taacgacttt ctggcgtttc 3865741 gttgattttg tgtaatattc tcaaacatat ttcaggattt gatttatatg accgatagtc 3865801 tttgcgatca attgttgagt acgtaagtgt atgctgattc aacaaatgta tctgtattgt 3865861 tcactttata atgaaatttc cattttggaa gcaaacccct gactgggtga taacgtctat 3865921 gtgcgatggc accaaaaact tggaggtcaa atagtccttt agagatgaga gttgttaagt 3865981 agccggaatc tagagcgacg gcttctactt gaaaatcaaa tcatgcaatt tagtgatcca 3866041 atcggtcaag gtagggcttg gaacagaatc atggactttt ctggagttgc aaactattaa 3866101 tcgtcctcat taaatttata ataaaaatat tctcaattga gcaaatcgcc cacccttttt 3866161 cctttataac ataaaatcca atactatcaa taaaattctt tacaggttat tacagttaag 3866221 atataatata gttaatcttt tacgtaaaag gaggttttta ttacttgtgt tgaagtttta 3866281 aataggagta actccatctc cccattacgg tcttcattta atttcatcct gagttttatt 3866341 tagttagata taaaaacgaa aatttcacat tatttttaac taaccgatag tataaaatat 3866401 atattgaaag gattgtaaaa ttatgaataa attcctgaag agcaatttcc gtttccttct 3866461 tgcggctgct ttaggcatat cattacttgc tagtagtaat tttataaaag ccagcaatga 3866521 taactataaa ttccatttac ttgtacctta tggctatggt aatgcctatt caaatgatgc 3866581 atttagacag accactcata cagataatcc ttggaaagta aatttacaga aatcggcaga 3866641 aggtaaaggt acaatcatga cattttggtt gattaacaca gggaatagta aaattccaaa 3866701 agcttctaaa atacataacg taaaacaagg aagcggagct cattattatc atgcaaatag 3866761 ccagggaagc catacatatg tagccttagc agttgaaaac aacaattaca gtgcaagttc 3866821 ttatggtata gatggtgtat gggatgaaga aacttggtaa acaagaacct tctaaaaacg 3866881 ttggcacctt ttagccacgc gaaaaaattt agaatgataa tctttttata agattatcat 3866941 ttttatttat tctattaaga attgagtgag aacatggaaa gtcatattta tcgcattatc 3867001 aaaaataaat taactataat aatatttact ataatcatat taattccttg tgttgatata 3867061 tcactattgt taatgactaa cacagaatac catcctgcat atgcgttttt cctttctggc 3867121 acttccgtag ggcatgcttc acaaatgatc ctattatggt ttcttccgct ttattttttg 3867181 ttactatgtg ctgacgattc tatacaagat tataaaacag gatatcatta cattcttata 3867241 agcaaagttg gcagaaaaaa atattgtttg gaaaaaatat ttacctcttt tatcatttca 3867301 tttttgacaa tgtttttgtc actaatatta aactttttat tggttcaggt tttctttttt 3867361 aaaggtacat ttaaaaatga cttagaccaa attaaattcc ctgataacag cctttatact 3867421 tttagtatgg cccatcctta tatagcaatt gtgttatttt ctattatttg ttgtattatg 3867481 tctggatttg ttggagcact tggttcaagc ctcagtttac tttttcgtga taagaagtat 3867541 gcctacccag caagtttttt tatttggttc gtacttatac taaaaaacaa atcattaatg 3867601 tttttattcc aaccgtttac agaatacggt tataatgtac ttctccctat cctatgtttg 3867661 tctatcttta tttttctaat aataatttct agtattgttt tatatgaggc aaaatacaat 3867721 gaaaattaaa agactactat taattttatg tttactacta tttttagtta ctttatggtt 3867781 caaccagaac cacacttatc ttggaaagaa ttctatcgcg tcattactat atatgaataa 3867841 tagtacattc ggatatagtt caatatttgc atataccttg ttttatattg tcccgtttct 3867901 tatgttactt agtaactttt ttcattcaga aaacccctac aaagtaatga ggatggttaa 3867961 gcgtaaaaat tactacaagt ctaaaattat ggagattggg tttgtttctt tacttttttc 3868021 ttcaatacat actgttatta atattacgtg tacacatatt ttctttagta aaaacttgtt 3868081 ggtcgaagca aactttttat caatttgttt attaaacatg attagtttag tgtttttcta 3868141 cttatcagta ggtattatgt ttagacttac atacgatctg tttaattcag tagcattagc 3868201 aatttttatt gtgtatataa ttttagatag cttgtatttc ggcgttaaat tattacttcc 3868261 taatggatat tgggaaccct ttagagactt ggctatattc acaaatatgc tcaatagata 3868321 ttggtcaact tcaaatctta taatagttta tattagacag ataataatag tttttatttt 3868381 ttatttagtt ggatcttcaa tttttttgaa taaggattat aaaaaatgag gattaaaggc 3868441 tttttcataa ctttagttgc gataatattt caggcgtcat tatcgagtta taataataat 3868501 aaaaatgtct ttcctttttt agatggcata ccaataagca cctcgggtca ttatgagtat 3868561 caaaatattt tattgtggtt tgtacctatt gtttccctaa gtttttgttt ctctgggagt 3868621 attagagata catacatttc gtatgagcaa ttaaagttag taagagaaca tagtagagtt 3868681 aaatgggtaa catctcaatt cttaataatt acagttgtac ttttaatctt tactttatct 3868741 cagattgcta tattttatat ttattcactt gtatctcttc ataaccttga tattaattcc 3868801 gttatcaata aaagatttgt tatgatgaca ctcatgtatt atctaacctt acttaactta 3868861 tttagttttc aattatttat ggagctttat tataaatctc aaatagcaca attaaatata 3868921 agcgtttata ttattttttc gttaatttta gcaaagaagt tagtgcaatt aaattctccg 3868981 aaagttattc actacttttt aattccaaac tacagtaatg gattaagaac tgggttaagc 3869041 tattattccc aatctggaac tgctattatt gaaccattat taggtttgtt tattataatc 3869101 attttacaga tttcaatagt tatattatct gtcttaaagt tcaaaaaaat agatatgcta 3869161 aaaagtgagg gcttacaatg attgaggtat taaacctaac aaaaaaaatt aaaaagacta 3869221 cagttttaga taatatctct tatacatttg aaaaaggaac aatttatgga ctatttggga 3869281 gtaatggttc tggaaagacc atgctacttc gtgcattatc cgggttaata gtccctactg 3869341 aagggagtat aactattaaa ggtgaacaat tacataaaga tatctctttt cctaaaagtg 3869401 taggattaat tatagaaaat atgcagttac ttcctcagta tgatgctttt actaacctta 3869461 aaattttgtc aaaaattaaa aagatcgcat cagataatga tatattagat tctattagta 3869521 gagttggttt ggaaaatttt aatagtgtaa aggttagtaa attctcgtta ggaatgaaac 3869581 aacgattaaa tattgcacag gctatttttg aaaaacctga tatattgcta cttgatgaac 3869641 caacaaatgc gattgatgaa aaaggagttg catttgttca tgacattctt ttacaagaga 3869701 aaaaaagggg agctaccatt attattacta gtcatcacaa ggaagatatt atatctttat 3869761 gtgacattgc attagaaatg aatcatggac gtctagaaac ttcagaaaaa gtaatatata 3869821 agaaagatag ttagtttaaa ctggctattt cttatccaat gatagactgc agacaagttc 3869881 aactgctgta atgctagaaa atccaatgaa atgctgataa ttgcgaagag atatgatcag 3869941 tcagaaaaca aatcttaaaa agaaaaagta aattcatcaa tatttctaat aaacctggca 3870001 aacaacctgt tcggaggcat tatagctact tcactgacgg gatatttatt tgatgtgaca 3870061 ggctccttac gctcagcttt ctggtgccgg ttttgtgttg ttgctgggat tggtttttta 3870121 tgtgtttgta ttaggggatg taaaacgaat taaactggaa taaagagtgc ttgctgaaaa 3870181 gcactctttt tctgcatcga aagaatactt aagataagtc actcccaaaa atcgtaacag 3870241 tctgacggtt aaacataaac ctctgcccgt tccattttaa tacggtttga acatatccca 3870301 atgagtcggc gttatacctt cccgctatcc gctggtacgc caataattcg tatacgccgt 3870361 ctctgtcaaa atcaaccgga tacaagcccg ataaaggatt cacccatcct tctatcggca 3870421 tttttaacac accttggctg ttataaatct cattcaaata ttccctgccc ttgtaagtaa 3870481 ggtcgaggat atacgtttcg ttttgctgat gactgataac gctcgcttta tattgatttt 3870541 gatacctcac actgtacttt aattcatcat tcaatacatc tgaattgaaa attcgccgga 3870601 actgcctgtt tagataggca aacacatatg cataaatagc accgccgctt ccccctgtgt 3870661 ccattactac tgccacatcc tcaatcttgt cgcctgtcat atcccccaga aaaagtgacg 3870721 gattgtatcc catattgttt tgaagctgaa tccgctgctc ctgatgggtt ctgccatcac 3870781 ggatcaccaa tgtgatattt ctccataacg ggctgccggg catttgattt ccagttagaa 3870841 agacctcgtc aataacgccg tctcccgtta catcgccgcg ggtagataca atgattgcac 3870901 gtgaggagac aggctgccga aatacgtatg gatgttgaac aagtcctctg ccttcataaa 3870961 accaataagg agccattctg atgtcataca cattcaattg tgtcaccttc cctaatcagc 3871021 tgaatgaatc attatatgca ggaatggcac atcaaagaca tatcttacac accaattaaa 3871081 tccgtaccat atgaattatc aattacacaa agccactcgc cttgcgcatt ctttttaaat 3871141 acataggtcg cccttctttc catcgcatac tcggagtcct ttttatccga atcaagcagt 3871201 gtctgagaaa gaacgagtac cgtgtcacct gcttccaaca ggatcatttt cccttgtgtc 3871261 gggacaatat gatgattgaa atagttcgca atcgtgataa acgctttttt gatttcttcc 3871321 ttgcctcgcg cgatcatgcc cggcttcaca actaaaacgg catcttccga ataataattc 3871381 atcagtgtat caaaatcttc attttggatt gccaaatcac acgcagagat gatgtctttc 3871441 aattgctgtt ccaaatgaat tcccccaatc atcatgattg gatatattat acatcgctag 3871501 accactgaaa ccttgaaaac aaaatgaaaa gtatcctttt ttcctatata atcaaataga 3871561 tatatttaac aaagtaccca agtgaagggg tgaacattat tgtctgcgga agtaacgtta 3871621 catgacaata tacattatga tttaagtgcg gattgccagc actgttttgg cctgtgctgt 3871681 gtcgccttgc cttatgcgaa gtcggcagat tttgcttttg ataaagacgg gggcacgcct 3871741 tgccgcaact tacaatcaaa ctatcaatgt tctatacata aagatctcag agaaaaagga 3871801 tttcgaggct gctctgcata tgaatgcttt ggcgccggcc aaaaagtatc ccaaatcact 3871861 tatgagggaa aggattggcg aaacagcccc gaaacggcca accagatgtt tgacgttttt 3871921 cctatcatgc agcagctgca cgaaatgctc tggtatttac atgaagctct ttctatagat 3871981 atagccaagc cgattcattc tgaactgaga accactttcg aaaaaataga aaggctcacc 3872041 agactcagca aagaacgctt gctgacactg caggtggacg agcatcgagc tgaggtcaat 3872101 gaatggctgt taaaaacaag tgaactggtg cgtgcccaag cccgccatcc aaaactcccg 3872161 aaaaaggtca gccggggaag tgtcctgatc ggcgcgaaac tgaaagggct tgatctgcga 3872221 ggagcaaatc taagaggggc gctgctcata gccgccgatc tgagaaatgc cgatttgaga 3872281 atgacagact ttatcggtgc agatatgaga gacgctgatc tcagcggcgc cgacctgacc 3872341 gggagcatct ttttgacaca ggcacaggtg aacgccgcca acggcgattc gaatacaaag 3872401 ctgccgctgt ctgtacgaac ccctgcccat tggaaataaa aaaggacccg ctaacggtcc 3872461 ttttttactg atcaattcaa tcctttttcg ttcctcttat ccggcatttt cacacttctt 3872521 gccaagtatc ccgacagcca taacgcaacc agcagcatga aggtgatcat accgacgacg 3872581 cccagccagt gaaaaccaga ccagaatagc cctccgattg ttccgaaaac acttgaaccg 3872641 gcgtaataaa agaacaaata cagcgatgaa gcctgtgctt tgttgtgaag ggctctcctg 3872701 cccacccagc tgctggcaac tgaatgccct ccgaaaaaac cgaatgtaaa gagggcaatc 3872761 cccagaattt tcactgccag catattgttt atcgtaaata acgcacctgc aatgacgatg 3872821 aaaatattca tcaccaatat tttcggatag ccataccgat caaccattct tccaatgaaa 3872881 gacgagctga aaatgcctac aatcatcaca ataaagatcc agctggaaaa tgctttatta 3872941 agcgaatacg gcgggcccaa cagcacatac acaatgtaat taaacaaggc aacattgctt 3873001 ccaagcagca aaaaaccaat gagaaacaag ctgaatagtt tacggtccct caagtggccg 3873061 atcagagaca ttcccaattt cccgagcttc aattttcttg gcgtaaaatg cctggatggc 3873121 ggcaaattta taaaaaatat aacactagca atcaaactaa tgacaccaat tgtccccatc 3873181 gccatatgcc aattcaagta ctcgctcagg agcccggaaa cgatccttcc gaaaacggcg 3873241 ccgattgcat ttccgctgat atatagcccc atcgctgatc caagacttcc gggttcaatt 3873301 tcttccccaa gataagccat cgcaatcgac ggaaggcctg cgagcgcaac gccttgaatg 3873361 gttctcaata cgagcagtgt atgaaagctc ggactaaagg ccgatgccag acagagaacc 3873421 gatgcggcca gcatggaaat acccataata ggcttgcgtc cccacacctc ggataatgaa 3873481 ccaaagacaa gcatgctcac agctaacagc attgtggtaa cagataaaga aagactcgcc 3873541 gcagtaggcg ttacatgaaa ttcccgcgtg aattcctcca tgagcggctg tacgcaatat 3873601 agaatcgcaa atgtattgaa acccgcagcg aagaaagcaa acgtaatttt tcgaaaaacc 3873661 ggtgtgcctt ttcgaatgta tgtcatcggg actttatcgg tccctcatca tgttgtggag 3873721 cactgccatt cataaacaat catcctttat ttcttacgaa ttcaaacatc ctcgagtctg 3873781 tttatattat tatcttagca ccgttgatat atgttgtata atgcatataa aatatccttt 3873841 tcatgcttat atgtaataag gagagatgat aattggaatg ggaacaactt gaatattttc 3873901 aaacactggc ccggatgcag cacgtcacga aagccgcaaa aagcctctcc atcacacagc 3873961 ctgcactttc acgctctatc gccaggctgg aaaatcattt gggcgtcccg ctatttgaca 3874021 ggcaaggacg atccatcagc ttaaatcaat acggacacat ttttttacga cgggttcagg 3874081 cgatgatgaa ggagtatacc gaaggaaaag aagaaatcca agccttatta aagccagacc 3874141 aaggcgtagt ctctctcggt tttttacata cattaggcac cacgctcgtg cccgatctca 3874201 tcggctcctt tcagcaggaa taccccaaca tttccttcca gctgaagcaa aaccactctt 3874261 attggctgct tgaacgatta aaatccggag atctggacct ctgtctcctc gcttcgatta 3874321 agcctgaaaa tccgatccaa tggatcaagc tgtggagtga agaactcttt gtatttgtgc 3874381 caaatgatca cccattagcc agtcgcgaaa gcattaccct gaatgagatt gccggggagc 3874441 gttttatttt attgaaaaag ggctatgcgc ttcggatgac ggtcgatgag ctgtttgaga 3874501 aggccaatat acagccgaac attatgtttg aaggagaaga agcaactact gccgcaggtt 3874561 ttgtggcagc cggtctgggc atatctattc tcccagacct gaaaggctta gaccaaagca 3874621 aaatcaccaa aatccgcgtc agctggccgg aatgtcagcg tgtcatagga attgcctgga 3874681 taaaaggcag gtttttatca ccggttgctg agacctttaa acaatatgtg atcagccatt 3874741 tttctgagta ggaaggattc aagcatgaat gtcaaaaaaa tcacgtcaga acaggattta 3874801 catacagcgt ttgaaatcag aaaggcagta tttgtagagg aacaaggctg tcccatttcg 3874861 gatgaattcg atgagttcga tacactccac ggtgactgcc agcacatcct ggcttatcat 3874921 cagaatgtac ctgttggcac tgcacgtgtc cgtatcgttg gccacacggg gaaactggaa 3874981 cgaatctgca ttctgaagtc ttaccgcaaa ttcggtttgg gaaaagtgat cgtcgatgca 3875041 ttagaacgta ttgtaaaaga acaaggcatt tctgccttca aactgcacgg ccagacacag 3875101 gcggcaggct tttatgaaaa gctcggctat cggactgcat cagaagaatt tatgctggac 3875161 ggcattccgc atgtgctgat gacaaaacaa gacgattctg cgctatagat tgttcacaaa 3875221 tttgtcactt atgagcatga acggttcatt ggtatactaa tcaccgatta tggagagaag 3875281 gaatgattgt atgccagcaa ataaaaaaga aggccttata tttggcgtga tgatgtgctt 3875341 tggaatggtt tgcgtcatgt cgatttacaa tgccatcatc aaccgagcca tctacgattt 3875401 ttcactgatg accgtttttg aaatggtcat cggttttatg atcgccctcc tgttagattt 3875461 actgttagtg ggccccctcg ccaagaagat tgcattccgc atgccgttcg acaagactaa 3875521 aaaaatttat gtcatccttg ccatgtcaac ttgtatggtg attggcatgg tactttgtat 3875581 gtctgtgttc ggtttagtga cagcggttct agcaaatggg ctgaacgggg acagcctctt 3875641 cagtgcttat cttatgattg tgttgaaaaa tttcatcctg gcctatccgt tgcaattact 3875701 gattatgggc ccattagtca gaggagtttt catgaaattt gtaaaaccaa agctcacagc 3875761 cgcaatttaa atagaaaagg agtgagcctg acactcactc cttttgctca tgaatcgaat 3875821 gtaaaacaag ctccgcaaaa gcctctgcgg caggcagctg ccattttttc tttttgggtg 3875881 tgagtaaatc ggatcgaggg cttcaccatg ctggagattt ttcagcttat gtttttcact 3875941 tccattaatc cctatacctt accacatagt ttttatacaa ttcttcgtta taaaggattt 3876001 cttcgccatg tgaagagcaa atgagcgttg gtttgatttg atctatgatt gagccgctgt 3876061 cgatgttctc atttatatca acactgaatc ttcttatagg tgggtgtaaa tcctccttac 3876121 ttgtgataaa aaggtcgccc gtcaatagcg tacgatcgat tttatgataa tacacaacat 3876181 gccccggcga atggccaggt gttaaatagt atttcagagg cagatgagca agcgtttgct 3876241 ccgtcagcgg ctgtacaata tgggctaccc ctgtgttctc cacttcattt ttgttcggat 3876301 atggctcttc cccattgatg tactttagtt ctttctggtg cgcaaaaatc ggaatatcaa 3876361 atctctctaa ccattttgat gcacccccga tatgatcact gtggccatgg gtaagcaaaa 3876421 tggcttttgg attgccgatc gctaacgctg ccctaatttg agcatcagca aaacgttcta 3876481 ttcccgtatc aacaatataa acatcatcac catctttgat aaaccaggta tgaaccggaa 3876541 tacgaagagg cacatcaagc tcaaattcac attgaaagac atgttctgat agttgtctca 3876601 aattcacgca aaccatctcc tgtggaaatt ttttgatagt tttaaagaaa acagaagtga 3876661 acggactatt ttcacccacg ctcgagctga ctggattctt gagaggaaac gccgattttc 3876721 gccagcatca gctcaacttg ttaacgttgt ccattaataa tcccttttgt tccccttctt 3876781 cacatattcc caatcacgtt ctatattctt cctcactcta tgaaggagtg cagaaatggt 3876841 ttccttttcc tctgaagtaa aaccggacaa ggccacttcc gtggaatgtt ctccttctct 3876901 tcttaacaat ggatatacct ttttcccttt ctcagtcggg aacagttttt ttattttttt 3876961 attttgctca tccggcagtt tttgaataaa tccctgcatt tccagcttct taatggcccg 3877021 cgcggccgtt gtccggtcca cttttatcat ttccgccaat ttttcttgaa taattcccgg 3877081 attttcgtat atacgcacga gatagagata ctgccctctt gttaagtcta aatctttaaa 3877141 ttcgatgttg cttatggaat ccaacgctct tgctatcatg ccgatctcac gcaaaatatc 3877201 attcattcct aaaacccctc acgtattttt gttgcaatta caacaaaaat gttttaacct 3877261 tactattata agaccacatg cgtgctgtac agtccagact aatatcagaa aaggattgat 3877321 tcataatgaa tataaaaaga ataacaactg aagctgattt acatgaagct ttaaagatta 3877381 gaagaggcgt tttcattgag gagcaacatg tgtctgaagc cgatgagttc gatgaatttg 3877441 atacgcttca ggaacaatgc cagcatatct tggtatatca tgagaatcag cctgtcggca 3877501 ccggacgcgc gcgcatcgtt ggccatacag caaagctgga aagaatctgc atcctaaaac 3877561 cttaccgtaa gtacggattg gggaagatca tcgtaagcgg gttagaggaa atcatgaaag 3877621 aaaaaggact gacttcatat aagctgcatg gtcaaacaca agcggcaggc ttttatcaaa 3877681 aactgggcta ccagatttct tcacaggaat ttatggagga cggcatccct cacgtcttga 3877741 tgacaaaaga aatatcgcgg aatataacat gaaatatatg tattacggaa taggcatact 3877801 catattaagt ttgggcattt ccttaaccat acaatcagga ctgggcacat cacccttcga 3877861 tgcccttttg gttggtctgt caaaaaaaat cggtcttacc gtaggaagct gggaggtcct 3877921 tatttctgtg atcctcttaa tctgcaacgc tatattaacg agaaaaaaac ctattttgct 3877981 gggcttgatt acagcattca ttactggaat aggcattgac ctatggttgt ttgttgtaaa 3878041 aaacaccatc tatctaaact cgttgttaag caaactgatt tgttttggaa ttggtttggt 3878101 gctcatcggt cttggaacag ccatctatct tcagacgaaa ttcgcatcaa caccgatcga 3878161 tcatttaaca cttattatcc gagatctctc caaaagaaca atattgtttt caaggacatt 3878221 ggtatacgct cttttcttag tattagccat catctttaaa ggccctatcg gcatcggaac 3878281 tcttttaacg gtttgtttgg gaggaatgct ccttcacgtt tttatgccta ttgtggaaag 3878341 acatttctta tcaaagaata gaagaggtta ttaagaaacc tcttctcgat ccaaaaaacg 3878401 aaacgcaaaa caagccccgt ttcgttgtca attctttatc tctggtactg ttgaggtttt 3878461 ataatcaatt aaaatttata gtaccaaaaa atcgcaattt catttgctgt tggaaagttg 3878521 gaataaagca tcgtatcaac cgcacctatt ataaagtgat gtttggcata aaaatgacaa 3878581 gctgaaatat taatatcttg ggtttcaagc ataagaccac aaaaatgatt ctcctttgcc 3878641 cactcaatcg ctttatgtaa taatgctgtt ccaacacctt tttttctata gtcttttgcc 3878701 acggcaatgt cctctattag tgcataccca ttccagttag aacggatctt aatccggcca 3878761 atgcagttgt tttcaagata atataaaaaa gccgctttcc cctcttcttc aacataacta 3878821 acatccatgt catcatcttc atattgttta aaataaggtt tagaaaatcg ttcctcagta 3878881 tatgtccaaa caccgttttc aaaagcaggt atcattctcc caaaaacaac gaaaggttcg 3878941 tttggtttat tgaaatcttt catattcaaa tgagtcattt tcatgatcat atcaatctcc 3879001 gccaatcgag ataatattta gtaaactcgt ttcgatacta ttcaacaaca gcttccaaaa 3879061 gtgtactctt taagagaaca gcattagata aggcatccat taccttatat atttcactat 3879121 cttaatgagg tatttcaaca gaggcttgtg gtacagtaaa aaggaataga aacaagagaa 3879181 aagaagatga acctatgccc actaacaata aactcaatga gaaatatcat acttccttca 3879241 actcgcccac aaccctgttg actagtatcc gtggagagag gaagctttga cacagcttct 3879301 gccattgatg acatctctat tgaagtatcc aaaggacaac caaggatcgc tctttgactt 3879361 tttcaagaag aaagtagagt gaataaagga gtgattgagt atgttaacaa gagaagatat 3879421 ctttaaacac gtcaaagaaa aatacggtac atcgcctgat tacccgtggg agaaataccc 3879481 aaactatgct tctttgagac atacatcaaa caaaaaatgg tacggtctta tcatgaatgt 3879541 tctcccagaa aaattaggct tggatggtca tggcgaaata gatattctaa atctaaaatg 3879601 tccccctgaa ataagtgatc gcttaagaaa cggggaaaat atcttacccg gatatcatat 3879661 ggataaggaa cattggattt caattgtttt agaacggaca gatccagaag gcgaaatcta 3879721 taacttaatc gagcagagct ttcatttaac caagtgaaga taaagagtgt tcctgctaat 3879781 caagctgcga agagtagtgg gcactttcat tttaggatac tgttcttcac tctgtccaca 3879841 aacgcaactt agttcatctg gtgcgagagt gggagaagaa tttcaaccaa cttcttatgt 3879901 aaaaggatga atagttatga caaataactt aaaacagaga agaatcattt tagatttagc 3879961 agttacttta gatggtttta ttgaagggaa aaatggagaa gttgattggt gtattatgga 3880021 ccctgatatg gggtttactg attttttaaa tcaaattgat actattttat atggtagaaa 3880081 aagcttcgat ttatggggac aatacattcc aaaaaatgaa gaccctgata cagaaaagga 3880141 actttggaaa ttggttcata gtaaaaagaa atatgttttt tccagaacac aaaatgagat 3880201 tgataatcaa gccatattta taaatgataa tattcttgaa gaagtaaata aattgaagaa 3880261 aaatcctggt aaagacatct ggctatatgg tggagcgagt ctcattacaa cttttataaa 3880321 tttggggctt gttgatgaat ttagattatc tattcaccct gttgttttgg gagaaggaaa 3880381 accgttgttt attgatgtaa aacagaggat aaatttaaaa atggtgaata caagaacatt 3880441 ttcctctggc gttgtgcaaa tcgtttatca ttggaatggc taacattgta aagtaacact 3880501 cgacagtaat ccttcttatt gaactaaagg ggaatccata aataatgggt tccccttaat 3880561 atactatgga attatcaata tcaaattttc tgtaataaaa gaggattgaa aaggacgatg 3880621 tctcctcaat taacatcatt aagcattata gtatattttc ttctccctct tttaagtaat 3880681 cggctaagtt ttgtatttat aaaaaaacga aagaaggtga tccaatgcct actaacaata 3880741 aacccaatag attaatcgct gagaaatcta cttattttac ttcaacatgc tcataaccct 3880801 gtggactggt tcccttgggg agaagaagca tatgaaaaag cgaaacgcga aaacaagcct 3880861 gttctcgtat ctattgggta tagctaacga tggctaatct aaagaacatg ctattgatgc 3880921 catgtttatt cattttacaa aaaaggatca accttgaatt actttcacaa gattgatcct 3880981 ttcactcatt tagccatgtc tccgcgaacg tttatataca ttcaagatta ctagccaaca 3881041 aataacaatg attcctgcaa aaagtatgag catattgcta tacaaatagg tagagtgatc 3881101 aacgtcaata ggcagcagcc tatgatctag gaagccgata gataataaac cgcctacaat 3881161 cgcaataccc gttccctctg ataaaaagct cgtgaaatta agcaaactca ttccagcgcc 3881221 cgcttccttt tctttcaaac tgctagacac aactgtagat ataactgttt ttgtgaaaga 3881281 tagcccccca aaaacaaaaa ttactataat tgtcatgatc catggtgctg catctataaa 3881341 aaaggcagcg attaaaaagc cggaagaaag caatgcactt ccaatagtta gtacatacaa 3881401 ggaacctttc cgatcaacaa gcaatccccc aatgtaacca aagatgatga cactcattgt 3881461 tccggggaaa ataatgccgc ttccaattgc tgcagtactt aaatggtgaa catctttcat 3881521 catgtaagga accatagaga caaatcctgc tactgtacca aatattagtc ctccgcaaag 3881581 ggttccaatc acaaaaaaga cgtttttccc taattcaggg tcaacaaaag ggtcctgagc 3881641 tttcctaatg tgttgcacaa atatgaagaa agcaaggata ctgatgatca gaaaagaaaa 3881701 tctataagat gttgtaaaca gcataaaaaa tacgatacct gcagacatca atataatccc 3881761 tgccatatca atgtgtcctc ttattctctc ttcctttttc aacaatttta taaggaatgg 3881821 aacggtgata attgttgcag ttggaataag cagcaaatac gaccaatgga tataatgagc 3881881 aaccattccg ccaatagctg gcccaacacc ttctcccatt gctaccaggg acccgatcag 3881941 gccaaatgct ttccccctgt tctcttttgg aatatagcgc gcaacgacaa ccatcacaag 3882001 agctgggaat gcggctgcac caattccttg aataaatcgg gctagaatga gaataggaaa 3882061 gaaagagtgt ccaacaaatc caatgatcga ccctaagcca tttaccataa tcccaaatag 3882121 aagcagattt ttgatgccca gctggtctga tagctttcca tatagagctg ttccaatgga 3882181 gaaggttaac ataaaggctg tattcaccca gtttgcactt gctggcagtt tattaaactc 3882241 gttggcaata tcaggtaatg agacgttcag aaccatttca tttaatacgc tgaaaaatga 3882301 tagaacacaa agccaaatca aaacttgatt gtgccgtaaa gttgactgtg aataagacgt 3882361 attcacaatt tcccctccat taatgagggc agacgcagtt tatagggtca ttgatacgct 3882421 tccctctttt aattgtaccc tgttcatttt attgcacttc ataataactc cccctacatt 3882481 tgattgatat gatcttatta tatatagact aaggattaaa cttttacttt ttttataaaa 3882541 atttgaccag attgcgaaac aaggaaaaac gttattcgca tttatctcaa gtggcaaaat 3882601 gaaacattag tttatatttt cacatcacaa ttatcgataa gcagtcagtt attgtatttg 3882661 tttaggataa ctgtggtaac ctgaatataa ccaacttagg aagaaggtga tcccatgcca 3882721 aataaaagta aacccaatag attaatcgct gaaaagtctc cttatttact ccaacacgcc 3882781 cacaaccctg tggactggtt cccgtgggga gaagaagcat ttgcaaaagc aaaacgcgaa 3882841 aacaagccgg ttctggtcag catcggttat tcgacgactt gtcattggtg gcctgggata 3882901 atcaaatcgt gtggaactcc attaaaagat aacagaagcc attttaaacg ataatactat 3882961 ttgttcaaac aatacagtct accttttatt tcattcattt tctaaaacct gtaatccgta 3883021 accacgcggt agcaggtttt tttatttgct tgacttagag ttaactctaa attgtaaact 3883081 aactttaatt aaatgagagg gatgatgttg ttgtattcca ttagtaaagc tgctgagaag 3883141 actagtatta gttcgtatac attaagatat tacgaaaaga ttgggttact tccaccacca 3883201 aaacgaaaaa acagtggaag gcgtttttat acggagactg atattcagtt catgttattc 3883261 ctgaaaagtt taaaggaaac aggtatgtct ttggaggata ttaatgagtt tgtcaaagac 3883321 ggatgcattt tggaaaaaat caattcggat gttaaatcgg cacaactctc cccatctata 3883381 aataaacgta ttgagatttt aaccaagcac ttagagaaaa tggaaattaa aaaaagggag 3883441 ctggaagaag tgatttctac tacaaaagga aaactggata catattattc aattttgaaa 3883501 gaggaagtgg aaaacaaatg aaacatttaa atatatacat aatgttactt ggcttctcta 3883561 ttttcacggg agctactttt aatcttgcaa aatatacagt tggatatttt tctccatcgt 3883621 cttctgcggc atggcgtttc ggtttagcgg ctgcagtgat gctcatcatt ttgattttta 3883681 ctgaaggtat aaagaagagt caattacgga aaaacgccgt ttcatacatt gttcttggaa 3883741 ttataggaat ctttggattt aatgccttgt tttttgttgg tttaaaatat acatctcccg 3883801 ttaacggagc attaataatg gggctgaatc ctttattaac agcaattctc gctcgaatta 3883861 tcttaaagga caacatgaca aaaaaacaag tactcggcat attctttgca ttcatcggtg 3883921 tattgttagt cattacacaa ggttctatcg aaaccattaa aaccttatca atttcaggag 3883981 gagacttaat aatctttaca ggtaacgttt gttgggcact ttatggcgta cttggacgtc 3884041 ggtttgtaaa ggatggtaca ccgctatcta caaccactta tacgatggtt attggtgctg 3884101 ttagtttaat agtagtttcc ttatttacat ccaaacctgt ttctttatcg aacatcccga 3884161 ttggagtttg gggggcaatt gcttttatgg ctttttttac aagtgttttg ggttacctat 3884221 ggtggaatca ggggattaaa gagattggag ctagtaaaac atctttattt ttcaaccttg 3884281 ttcccgttgt aacgatgatt atttcatttg ccgttggaac accaataaag gtatttcaag 3884341 ttattggggc tgtgctagtt atattaggcg ttttaaccgc ttcgggggta atacgtattc 3884401 ctaagtacaa tactaaagaa cagtcagcta tataaagaaa tagggagtat ttttgagaaa 3884461 atgtgttaag ttaaatatac actaattata ggaagaaggt gatcccatgc caaacaaaag 3884521 taaacccaat agattaatca atgagaaatc accatattta ctccaacacg cccacaaccc 3884581 tgtggactgg ttcccgtggg gagaagaagc ttttgaaaaa gcaaaacgcg aaaacaagcc 3884641 ggttctggtc agcatcggtt attcgacttg tcattggtgc cacgtgatgg cccacgaaag 3884701 ctttgaagac gaagaaatcg cgcgtcttct caatgaacgg tttgtggcga ttaaagtcga 3884761 ccgggaagag cggcctgatg tggattctgt ttatatgaga atctgccagc tgatgaccgg 3884821 gcagggcggc tggccgctga atgtgtttat cacgcctgat caaaagccgt tttacgcggg 3884881 tacatatttt ccaaagacga gcaaattcaa tcgtcccggt tttgttgatg tgcttgagca 3884941 tctgtctgag acgtttgcga acgaccgcga gcatgtcgag gatattgcgg agaacgccgc 3885001 taaacatttg cagaccaaaa cagctgcaaa aactggtgag ggccttagcg aatcagcgat 3885061 tcaccggaca ttccagcagc ttgccagcgg gtttgacacg atctacggcg gtttcgggca 3885121 ggcaccgaaa tttccaatgc ctcatatgct gatgtatttg ctacgttatg atcacaatac 3885181 agggcaggag aacgctctat acaacgtgac gaaaacattg gacagcatgg cgaatggcgg 3885241 catttacgat catatcggct atgggttcgc ccgctattcg accgatgacg agtggctcgt 3885301 tccccacttt gaaaaaatgc tgtacgacaa tgcgctgctg ctgaccgctt atacagaagc 3885361 ctatcaggtc acgcaaaaca gccgctataa agagatttgt gagcagatca ttacgttcat 3885421 tcagagggaa atgactcatg aagacggaag ctttttctcg gctttggacg cggacacaga 3885481 aggagaagaa ggaaagtact acgtgtggtc aaaggaagag attctaaaaa cgctcgggga 3885541 cgatctcgga acgctgtatt gccaagtgta tgacatcact gaagaaggaa actttgaagg 3885601 caaaaatatt cctaacctca ttcacacaaa gcgagaacaa atcaaagagg atgccgggtt 3885661 aaccgaaaaa gagctcagtc tcaaactcga agacgcaaga cagcagctct tgaagacacg 3885721 cgaggaaaga acctatccgc atgtcgatga taaagtgctt acctcatgga acgcgctgat 3885781 gatcgcgggt cttgcgaaag cggcaaaggt ataccaggag ccgaaatatc tcagcctagc 3885841 gaaagacgcc atcacattta ttgaaaacaa attaatcatc gacggccgtg tgatggtccg 3885901 atatcgtgat ggcgaagtga aaaacaaagg ctttatcgac gattacgctt ttctcctatg 3885961 ggcttatctg gatctctatg aagcttcgtt tgatctttct tatttacaaa aagcgaagaa 3886021 actgacagac gatatgatca gcttattttg ggatgaggag catggcggat tctacttcac 3886081 cggacacgat gcagaagcct taatcgtacg ggaaaaagaa gtgtacgacg gcgccgtgcc 3886141 ttcaggaaac agtgtggcag ctgttcagct gctgcgtctc gggcaagtca caggcgactt 3886201 atcactgatc gaaaaagcgg aaacaatgtt ttccgtgttc aagccagaca tagaagcgta 3886261 tccgagcggc catgctttct ttatgcaaag tgtgttaagg catctgatgc ctaaaaaaga 3886321 aatcgtgatt tttggcagcg cagacgatcc agccagaaaa caaattatag cggagcttca 3886381 aaaagccttt aagcccaacg actccattct ggtggcagag cagcccgagc aatgcaaaga 3886441 cattgcgcca tttgcagcag actaccgcat catagacggc aaaacaaccg tttatatttg 3886501 tgaaaacttc gcctgccagc aaccgacaac aaatattgaa gaagcgatcc acacattaat 3886561 aagcagcagg gattaagacc cttgctgctt actttttgat ttcttatggt accataaagc 3886621 gatccccgca aacacaaggt tgaccgctat cgtaaagaaa gcctcccaca tcgggttccc 3886681 ccgcgtaacg gtaaacagag aaggaattcc tccatacaca ctgttttttt ctgtaataaa 3886741 catacacaaa aacatattat tcgcggcatg ggcgccaagt gatatttcga tgctcccagt 3886801 tttaatcgtg taatacgtcc acacaaaccc aaatgttaag tactcaattc ctgcccagac 3886861 agcgccattg ttcatttctg gattcgcaaa atgcaatacg ccaaacaatc ctccgacaat 3886921 cagtgtcaaa aatagaggat ttttcgtcaa tctcccgaaa gcttgaagca aaaatcccct 3886981 gaaaaatagt tcctcagctg atgtctgaat cggaaccaaa atgagggcag ccgctagcag 3887041 ccagataaat cgtgatgcat taaactcttg cattgaatag ctatcaggat gaatcacaaa 3887101 atcaatcaat tgtacggcga tcattagcaa gaaataagca ataaaaccaa aggaaattct 3887161 ccgccaattc atctttgaat ttggtgttat caccgttcgg aaaggccgct tcaaaataaa 3887221 gcgcacagcc agccaaactc ccggaatggc gaataaataa atcacatggg acaaataaag 3887281 atctacgagg ggatcactca gcacagcttc atccaaatca aacgtgatat tgggattcac 3887341 aataaccgtg aacaatatag cgaaaaggta agctatattc cctaatacat ataaccctac 3887401 catcaccaaa aaagcgaaaa aatatctcca caacgtattg tttccttcta taggacggat 3887461 aaatgaattc attccttcta tgtctcttcc tttcaatgag aatattacta tatatttgca 3887521 taaattggtc tatgaatcta ctgttttgga aatcttttaa gcaaaattaa aatataaagt 3887581 gtgaatttag ttcttccatc tagtgatttg aactctgttg ccaatgaacc aagatactta 3887641 taatagtccc aagaggggaa ttttcagtct tttctactac tcaaaagggg gttttttatg 3887701 aatacgatct tcaaacaaaa gaatacacat cctttctcaa acgcagcgaa tcgtttagac 3887761 cgccttccga tttcacgcgt tcatttccaa gtgttaaccg ctctcggcat tgtttatttc 3887821 tttgatctcg cagatttatt taccctcagc aacgtagcgc cggcactgat cgagcattgg 3887881 ggcatcccgc tttcaactat tgctaacgta acggccgctt cgtttttagg catgttttta 3887941 ggcgcttcac tgggcggacg gctgtccgat cgaatcggcc gcaaaaaagc cttaaatcta 3888001 tttgtctttg ttttctcaat cgcatcgcta tgcaatgctg cggcatggga cattccatct 3888061 ttaatgacat tccgtttcct caccggattt ggcgttgcag ccgccatggt cattacgaat 3888121 agctatttgg cggaattttt cccttcaagt gtacgtggaa aatatatttc tttttgtgcc 3888181 atgattggat tgattggggt tccgatcacc aacattgtgt ctgcctttgt cattcctctt 3888241 ggttcatggg gatggaggct agtatttgta tggggtgccg tcggccttat ttattttttc 3888301 ttcatccacc gtctggaaga gtcacctcgc tggcacgaaa atcgcgggga atatgcgaaa 3888361 gccgatgcga tcctcacccg aattgaagaa caggttgaaa aggagaaagg cccgcttccg 3888421 gcagcatccc agcctaaagt aagcgaaact gttaagcaga atgcaggtta cgcaggctta 3888481 ttgaaaggca gaaacctcaa aattaccatc gtattatctg ctgtatggat ttttgaaacg 3888541 tttgggtttt acggatttgc ttcatgggtt ccaagcctgc taaaaagcaa tggcgtaacc 3888601 atggaaaata cattatggta taacgtattg cattccgtcg gcgctccact tggcgcactg 3888661 ctcggctcca tgatttccga aagatttcaa agaaaatgga ttttagctgc gagtgcgttt 3888721 ctgacggcca tcgccgggct cttatatggt atgactttta ttcccatcat gatcattgta 3888781 tttggtttta tcgtgaatat cacagaacgg gtctttacct cgaacttata cgcctataca 3888841 tctgaacctt atccgactga ataccgctcg tctggcagcg gtttagccta tggtcttggc 3888901 cgtttttcaa acatttttgg ctcattgctt gtcggattta ttgccgttca gctcggctat 3888961 atcagcgtct tcttatttat tgggggctgt tggctcgcat gctccttgct gttaatcttc 3889021 ttcggtccta atacgaatgc aaaacagatt taaaaaagtc agtgcggatc tgccgcactg 3889081 atctcattac aattgcttca aaatccttgc ggggtttccg cctacaacag tattagcggg 3889141 tacatcctta gtgacaacag atccagaagc aatcactgcg ttatcaccga ttgtcactcc 3889201 cgggttaatc accgcccggc ctccaatcca aacttgatct ccaattgtca caggcttacc 3889261 gaactccttc ccggatttcc tttcgatcgg atcaagagga tgaccggccg tgtagatatg 3889321 tacacctggc gcaatcaaac aatgacagcc gatacgcacc tcacacacat ctaaaatgac 3889381 acagtcaaaa ttaacaaatg tatgatctcc gatatgaatg tgatagccat aatcacagcg 3889441 gaatgtcggc aaaatcgtga cttgatcccc aaccgaaccg agcagctcct tcaaaagctt 3889501 cgtccgcact gcatcatctt ccggtgtttc gttgtattgt ctaatcagct gtctcgcatg 3889561 cttgcgttct agtaatagtt gttgatcttc cgaattgtat aattctccgg ctgccatttt 3889621 ttctttttct gtcctcagca tttaagtcac tccagatgtc agattgtaat ctcgatcaaa 3889681 tttccttcat catcctcaat cacgctttca tagtagccgt ctcctgttgt cctcgggccg 3889741 tttactactg cgaaaccatc cgccttcaat cgatcagtca gttcgtcaac tttctcccgg 3889801 ctcccaacgg aaaaggcaat atgtgcccag cctgtcattg tttgtgaggg cggatcggtc 3889861 acattccctt ttttcataat ttccagcctt gctccggaat caaacgtaat aaaataagac 3889921 ttaaaatctt ttttctcatt atgatacaaa tcattcgctt cgccattaaa atacgattca 3889981 taaaaagact tcattcgctc taaatcattg acccagaccg ctgtatgttc aatctgcatt 3890041 tcttcctcct ccttcgcctt caatgaagtt ataaggtatg aaatgcattt cagttcaagc 3890101 ttttttctta aatttatgct gaattttgat atcagcgggt tcatcctgca aaaatagaga 3890161 aaatgctgcg atgccgagct gctcaagatt caaatcaagc gacggaaaac caagaacacg 3890221 gctgatagaa gtatttccct cgcctatgat ttcaacatcc caattattct ttttggcaaa 3890281 tagatgaatt ccagctgcca cttcatcact atttgcataa atagcagtcg gaacccgccc 3890341 gctcatataa aaatgttcag ctgccagctc accatcattc atatcgttgc atccggacag 3890401 catatggcgg tcttccaacc ttccgcagac agctttatag gccgcagctt tatcagccgt 3890461 gctcgggctc ctatcagctt ctctgacaca cgtaaaagca atattctcat gcccgcggct 3890521 ctttaaatag cgaaagctct ctgcataagc agtttttctg tcattaaaag cacaagggac 3890581 atcaatgtct ccggtatcct cacaagcgat gaccggccca tattcctgat aagctaaaat 3890641 gctgtcccaa tgattggcgc gggaagtaat gatgagaccg tctattttct tcgttcttaa 3890701 cagctctaaa tatttgattt caatatcggg gttataattg gtggggagaa gggtcgttgc 3890761 atactcatgc tgaaaagccg ccttggtgat tccgttaacg attttatcaa agcagggatg 3890821 atcgctataa ggcagaatca caccgaccgt atgggttttc ccgcgaatga gatcgattgc 3890881 ggttcgattt ggtgtataat ccaattcctt catgacttga tgaacaagct ttctcttttc 3890941 ttcagataca tacggatgat gattcaatac acgcgagaca gtcgaaacag atacatttgc 3891001 cagtcttgcg atctctttta tatttgccat ctctttctcc ttttcatata aaaaaagcag 3891061 taagtgtaaa atccttactg ctatctcatc atatattgat gataagttca acaggacaat 3891121 ggtcggaacc catgacgtcc gctgatatgc tggcatcttc aatctgttcc ttaaggcttt 3891181 cagaaacaac aaaataatca atccgccatc caatatttct gtcccgggcg ccggcacgat 3891241 acgaccacca ggaataagcg ccttcaagat caggataaac atgacgaaaa gaatcaacaa 3891301 agccagcttc taagaaacga gtgaatgcct ctctttcttg atctgaaaat ccagcgttat 3891361 tccggttcgc ctttggattt ttcaagtcaa tctcctgatg ggctacattc aaatcaccgc 3891421 ataaaatcac tggttttttc tgatccaatt caagaatata agacagtaaa gcctcttccc 3891481 attgcatgcg gtaatcaatc cgctctaatc cccttctgga attgggcgtg taaacagtca 3891541 tcacaaacac gttttcaaat tccagcgtaa tcactctgcc ttcttggtca tgctcttcta 3891601 ctccgatacc gtagatgacc tgcagcggtt cttgcttaga aaaaacagct gtgccggaat 3891661 atcctttttt cactgcataa ttccagtaca catgatagtc ttcaggctgg agatcaacct 3891721 ggccgtcctg tatcttcgtt tcctgaagac atataatatc tgcatcctct tctttcaaat 3891781 aagagaggaa atccattttt ctcatcacag cccgcaggcc gtttacattc catgaaatca 3891841 acttcatgtt tcatcctccc ccctataaaa aagagcaaga acccgaaggt ccttgctctt 3891901 tacatatcag cttactcacc gcttacgtat ggaagtaaag ccatttgacg tgcgcgtttg 3891961 atcgctgcag tcaatttacg ttggtattta gcgtttgttc cagttacacg acgtggtaaa 3892021 attttaccgc gctcagaaac aaacttttta agaagatcta catctttgta gtcgatgtgc 3892081 gtgataccgt tagaagtgaa ataacacact ttacggcgtt tcgcacgacc gcctctgcgt 3892141 cctcctgcca ttgtcatttc cctcctttct ttttcatttt aggcgataat cacattagaa 3892201 tggaagatca tcatccgaga tgtcaatcgg tttgccgtcg ttggcaaatg ggtcatcatt 3892261 aaagctgttc ccctgattgc gtctctggtt gttttgattt cccccaaatg gattatcatt 3892321 ttggcctccg ccaaagtact ggcctccgcc gctgtttcct tcgttgtatc cacctgaacc 3892381 agaaccgccg ccgtttttcg gctcaagaaa ttgaacactt tcagcttgga cctctgtcac 3892441 gaagacacgc tgtccttgct ggttttcata gtttcttgtt tgtaaacggc catctacgcc 3892501 tgcaaggctt ccttttttca agaagtttgc aacgttttcg gcttgtcttc tccaagtgac 3892561 acaattaatg aaatcggcct cacgttctcc ggactggttc gtaaatgtac gattcacagc 3892621 aagagtaaac gtagcaacag ccgcaccgtt tggcgtataa cgaagctctg ggtcttttgt 3892681 cagtcttccg actaatacaa ctcggttaag cataagaaag accacctttt accattatat 3892741 atttcaaaat tgcttattct tcttctttaa caacaatgtg gcgaatgata tcgtcactga 3892801 tcttagctag acggtcaaat tcttgaactg ccgcagcgtc agattgaacg tttacgattt 3892861 ggtagaaacc gtcgcggaaa tcgttgattt cgtaagcaag acgacgttta ccccaatcct 3892921 ttgttccagt gatctccgca ccgttagaag tcagaacgtt gttgaaacgc tcgataactg 3892981 cttttttaga ctcttcgtca atgtttgggc ggataatgta cataacttcg tactttctca 3893041 tctgtttgca cctccttttg gactaagcgg cccataatgg gcaaggagca ataattctat 3893101 tactcacaat tttatattat accaaagctc ttgtcccttt acaactgcat cctatacatt 3893161 aaatcggaaa tgaataacat ctccgtcttg gaccacatat tctttccctt caaggcggac 3893221 ttttcctgcc tctttagctc ctgccatacc gccgcccgca agaagatcct cataagcaac 3893281 tgtctcagca cgaatgaagc cccgctcaaa gtcactatga ataattcctg cacactcagg 3893341 ggctttcatg ccttttttga atgtccaagc tctgacttcc tgttctccgg ctgtgaaata 3893401 tgttgcgagg ccgagaagag agtaagacgc tttgatcagc tgatcaagac ctgattcttg 3893461 aatgcccagc tcttccaaga acatttgctt ttcttcgcct tcaagctcag cgatttcaga 3893521 ttcgattttt gcacacacaa cgataacttc tgcgttttcg ccggcagcgt actcgcgaat 3893581 cttcgctaca ttttcattgc cagatggatc agcaacttca tcttcactta cgttggccac 3893641 gtacaaaata ggcttcgaag tcagtaaatg gagctgcttc acaagctttt gctgctcttc 3893701 agtgaattct acagatcgag caggcttttc actctcaaac gcttctttca gtttagataa 3893761 aatctcaaac tcaaatacag cgtctttatc tttttgcttc gcaagcttgc tgacgcgtgt 3893821 aatccgcttt tcaactgttt ccatatcagc gaggatcagc tcaaggttga tcgtttcaat 3893881 gtcatcaatc ggatcaacct ttccggaaac gtgtgtaatg ttgtcatcgg aaaaagcacg 3893941 gacaacgtgg caaatcgcgt caacttggcg aatatgagat aggaacttgt tgccgagtcc 3894001 ttctccttta gatgcgccct ttacaatccc tgcaatatca gtgaattcaa aagcagtcgg 3894061 cacagtcttc ttcgggttga ccagctcagt cagcttttgc agacgatcat ccggcacctc 3894121 tacaattccc acgttcggat caattgtaca gaacgggtag ttggctgatt cggcaccggc 3894181 ctgtgtaatt gcgttaaata gtgttgattt tccgacgttc ggcaaaccaa caattccagc 3894241 tgttaaagcc attctttcat ctcctctata taaaaccgtc attgtatgaa cgtattttga 3894301 acctagagca attataagga ggttcactgg aaaagacaag ctgacaaaaa agcattttca 3894361 gcttgccaat ccctttgatt atgctttttt caagcctact aaacagtcaa aaagcgtact 3894421 tcccattcca ttatcagaat ttgtatcatt tgtcagtgca ttgactgacc ctccaaaagc 3894481 cgcccacatg ccttcatcta tattaatcgt cttcgcatga gcctgcttca tcactttcac 3894541 cttgcccttc atgcttccgc ggtcattaaa gatgacaact tcgtctccat cctgaagatc 3894601 ctgcccagcc gctatatctg gagaaatatc gacctgaacg tgctgaagct tttcaataaa 3894661 cggcacatgc tgtgaatgat tggaacgctg cggatgaatg gataagagcg tataagggta 3894721 ctttccagct aactcctcat tatggaaaac agattcttcg ggcacattta attgaagcga 3894781 gccgctaaat cctttttgct cagctagcga cgaagtaaat tcaaattttc cactcggcgt 3894841 caaaaactga taatcatccc acggcacctg ttttactgga agagggaggt ggcctttttc 3894901 ttttaaacgc tcaagtgtca catcctctgc ttccaatgaa gaaagcccca tctctaaaaa 3894961 ttcttgagtg ctgtattcaa acagctcgcc aaacccaaga cgttttgcaa gctctgacca 3895021 gatccagctg tccgatttcg cttcaccctg cggctccaca agcttcttcc cgtactgaac 3895081 ataatgatga tacatactgg aatagtagat atcttcttct tcaaaaacag tggcagtcgg 3895141 caaaacataa tcacacagct ctgcggtatc cgtcataatg gaatcaatcg cgaccgtcat 3895201 tggaaccttt tcaaatgctt gtctcacctt atttgtattc ggcacctgag tcagcggatt 3895261 tccgcacgtc acaataatca tctcaatcgc aggatcagca gcggtcaaca cttcttcagc 3895321 ctgtgtcatc attgaaaaag aacgggatgt tgtttttaat tccggcagcg tcagctttgt 3895381 ttttgcaaag ctctcaccaa tctggacatt tccgaaattc gcgccgccgc ccttaattcc 3895441 gacatttccg cttgccgcca caagtgcatc aatccaacga atcgttcccc cgccgttttt 3895501 atatcgctgc atgccaagcc ccataaaagt agacaccgga ccatcagcat acaaacctgc 3895561 caaatactcc agctcctcca tagaagtttc tgttttcaca ataaactctt ccagagaaac 3895621 ggtcttcaaa agctctttca catcatcaaa accgacagaa tgctcagaaa taaacgtttc 3895681 atccgttctt cccatctcaa tcagaacctt caaaacggct gccgcaagcc agccgtccat 3895741 tccaggcttt acagagatat agcggtcggc aagcttagca gtcgggttga agatcggatc 3895801 aatcaccgta atcgtggcgc ccttcttttt cacctgctgc aagtgatggt ataagtgcat 3895861 atttgttctt gatacatttc ttccccacac aacaacatgc ttgctgttgt aaatatcaag 3895921 cggtccgtga ccgtacgaac ggccaaaatc ccagctttgc gcctcgatac cggagcccca 3895981 gcatatgctt ccgacgattt cggtcacgcc gccatatcca ttaaaaaaac gctgatcaag 3896041 cgcttttaac agaccgttat tcgcataatc atggctgtgc aaaacagcag tcgtctccga 3896101 cgtttccttg atttcccgaa gtttatcggc aatttcatca agtgcctgct cccaagaaat 3896161 ccgcacaaac tcgccatttt gttttttcat tggatagcga agccgatcag gcgaatttgt 3896221 ttttgtctca agcattctgc cgcggccgca gattttacct tccgtaatcg gatggtttgg 3896281 atctccgtcc acttttgtta cctttccatc atcaacagtc accaaaaagc cgcagctgtc 3896341 ccaacaattc agcggacatg ccgactgatg cactttgctc atcgccgtct tctccttacc 3896401 ttctatatga aaaagcatga gtgtcggcct atttatgaag taggctcctc atgcttgact 3896461 agtacttttt ttagttttct ttcaaattct cttctcggaa tcataacact gtgagagcat 3896521 ccctcacact taattcgaat atccattccc atgcgtataa ttttccagct gttcgctccg 3896581 catggatgcg gttttttcat ttctacgata tcattcaggc caaagtcttt atccgccaag 3896641 acccttcacc tcttttccta aactgctgta tctattgtac aaaaaaactg atcataagag 3896701 caatcaagat acccgaaaag aaatacatcc tcttatttcc atttactcaa aataggatat 3896761 aagagcagac aaactaacaa atacaaattg agcatcccat atatcggata caagaacgcg 3896821 atcaaatcag aaaatccgaa agaagtaaaa ggtaccatta acactaacaa aatcaacaca 3896881 atcatccatc tcggcatatg aataaacgcc atcagccggc tggacaaacc cagcaaacca 3896941 gctaccgtcg tcgtgtaaat cgccaggcac agcaccgccg tcatacataa aaaaaggaaa 3897001 taaggcgcac cctccagaac ggcaaacagc ggtatttcaa actgagaaag ggagcccgcc 3897061 agctccacca acgtttcatt ataaacaaat gagatcacgc caaaaataag accgcttgcc 3897121 acacttgcga tttttgcttc tccgagccct ttcatctctt tcccaacaga ggataaaatc 3897181 gcaacaactg aaaggatgtt taaagaggta aacgtaatgc tcgcaggcca gttatactgc 3897241 tgggacaaat caatcgtcca cgtatggtga tgtgtgctct gaaaggagat cagcgcatat 3897301 aaaagccccg ctactaacac aggaatcaaa atactattta tagataatat tcctttcaca 3897361 tcccacaaaa acaagcacac tgtcacgatg caaatcagcg tgattcccca ccagaaagga 3897421 agcttgtaca tttgcagggt cacaccgcct ccggcaatca tcaccatagt cgtcgaaaac 3897481 aaataaaaaa tgatgaggac atcataaatt ttcgccagcc atggccccat taaatgctcc 3897541 agaaccggca gaaaatgagt ggattgaacc ttaaaactga ttttcatcac aatataagac 3897601 gagaaaatga acataattgt aaacagcaca atagcaagtc cgctttccgc cccaaaaaac 3897661 tgccatatct cctgaccgct cgcatatccg gccccgatca ggctccctaa tatgagcagc 3897721 atccacttca ttccggctct ccacaacact atcacctcat agacaaagtt cagcttgttc 3897781 ccgttattgt tactatataa ataaaggaaa gcaaacatgc catattttca tagacatttg 3897841 aacacaagct gaaattatca tacgaaatac acataaaaaa gactgctaat acggcagtct 3897901 aaaaagagat atttatttgt ttgtccgcgg aatgaagaag tgaacttcac tcttcacttt 3897961 tttctaacca ttcctaccta ttcaagtgtt tcataagcag accattgctt gatcatgatc 3898021 gaggcaatgg gggacaatac ttgtaatcgc ccactaacca ttcatatcat gccctctact 3898081 tttttaaaat ctctggtgcc atacacaaag cataaaaaat catactgctg gatatactgt 3898141 aaacaacctt acataactac acacaccata gcaattctgt tacctactat aacaaggaag 3898201 tgaaacccat gaatcgaaaa ggcgggcttt tttcttctca ggaacgagta aagcaatatg 3898261 tttcacatac agatgctgca gcggcaaaac aaatccaaac catcctttct tcatccttac 3898321 gtaaagctgc tggcaaacca attgtcgtgg tttgtatcgg aacagaccgt tcaaccggtg 3898381 actcattagg cccgctcgta ggaatgaaac tcaaacagat gcagctcacc agattccatg 3898441 tctacggaac cttatctgac cccgtccatg ctgtgaacat gaaggataaa atcaatgaca 3898501 ttcataaatt acataaaaac ccatttgtta tagcagtcga tgcatgctta ggccgcgtta 3898561 agagtgtggg ttcatttcaa atcggggacg ggccattaaa gcccggagcc ggtgtacaaa 3898621 aagaccttcc tgaagtggga gatcttcata ttaacggaat cgtgaatgtg agcggtttta 3898681 tggaatattt tgtattgcaa aatactagac tcaacttggt catgaatatg gcaaatgttc 3898741 tagcggaagg tttgagttta acagatcgga cagagtggag gcaagaacgc cttaacccgt 3898801 tgcaaaggct cactgggcgc atataaaata aaaaccatct tcgtttgaaa gatggttttt 3898861 tcatttatga ttctcgttca gacaaaagct ctaaaatccg gtcaaggtct tcattagaga 3898921 aaaattcaat ttcgattttg ccttttttct tctgtctttt aatattaact gttgttccaa 3898981 aataattttg gagataggat tcccgttctt ttagaaccgc atctttcaca ggttcttttt 3899041 tctttgtttc acgtggaaca ttctgattca actgctgaat cagctgctca agttggcgaa 3899101 cattgagctg ctccgcaatc actttttgta ccagcggttc aagcttattt ttgtttttta 3899161 agccaagaag cgtgcgtcca tgtcccatag aaagcgtgcc ttcggcaata agctgttgaa 3899221 tattttctgg cagtgtcagc agtcttaaat gattcgcaat atgcggtctg cttttcccaa 3899281 gacgtttggc aagctgctct tgtgtgagat ctaagtgttt caaaagggag tcatatgcct 3899341 gagcctcttc aagcggagat aaatcttcac gctgaaggtt ttctaataaa gcaatttccc 3899401 tcattaacgc ctctgataat tcacggacaa tggccggaac tgtatctaaa cctgccagct 3899461 ttgccgctcg aaaacgccgt tcacccgcaa caatatcata gccttttaaa gattttctga 3899521 cgataagcgg ctgaagaatg ccatgctgca gcacagattc ttttagttca gctaatgcct 3899581 cgtcatcaaa gtgttttctt ggctgataag gattagggcg taaatcggca attttaattt 3899641 cttcaactgt ctcttcagac aaatctacct gattaaataa cgcattaatc ccttttccaa 3899701 ggcctttagc cattcgcagc cacttccttt gctaaatcta aatatacttc cgcacctctt 3899761 gaccgcggat cgtataaaat gatgggtttt ccgtgactcg gtgcctcact cagacggaca 3899821 ttacgcggaa taactgtctt atatacttta tccctaaaat actttttaac ctcttcaatc 3899881 acttgaatgc caaggtttgt ccgggcatca agcattgtca gcaatacacc ttcaatcatt 3899941 aaatcagtat tcaaatgctt ttgcacaaga cgtactgtat ttaataactg gctgagaccc 3900001 tccaaggcat aatattcgca ctgtacagga atcacaacgg aatccgaggc agtaagggca 3900061 ttaatcgtca gcaagcccaa tgacggcgga caatcaatga taatataatc ataattttgc 3900121 tttactgctt caagcgctct cttcaatctc acttctcttg atattgtagg aaccagctcg 3900181 atctcagccc ctgcaagctg aatcgtcgca ggaatcacat ccaagttctc tactgtcgtt 3900241 gctttaataa tatctattac atctgcatca tctactaaaa tatcgtacac acactgctct 3900301 acatcggctt tttcaatccc taatccgctt gtcgcatttc cctgcggatc aatatctacc 3900361 agcagaaccc ttttccctat gtaagccaaa catgccccaa ggttgacaga cgtcgttgtt 3900421 ttgccgaccc cgcctttttg gttcgtaatt gctatgattt ttcccacgat gtcacctact 3900481 ttcacatgaa catgtactat cttgcttcta ttctatcaaa aaaagattaa agcgtttcat 3900541 ttttttcatc attttgttcc gaatcagaag ggaaataatt gaaaattcaa gcacgcttta 3900601 tgctttctct tataaattct gcaatttcta tgtttttttg acttaaaaaa ggaatttctt 3900661 aaagaaaaaa agaagaagtc acagtacaga acgtggaaac aggatggtga gaaaatggtt 3900721 tatcaaacga agagagatgt acccgttacg ctgatgattg tgtttctcat attactgata 3900781 caagcagatg ccattgttcc ttttgtgctg ggaaatatga gagtttccgg ctggatcatt 3900841 tttattctgc tgactctttt aaatggactc atcatttgga gctttattga cctaaaatat 3900901 gtattgaagg aacaccatct gatcattaaa gccggattga tcaaacatca aattccttat 3900961 gaaaacatcg ataaagtcgt tcaaaaaaag aaactatggt ccggttttcg tctgatcggc 3901021 tctcgccatg ccatcacaat atattatcag gggggatggg gacatgcagt aatttcaccg 3901081 caaaaatctg aagaatttat ccacaagctc aaagaaaaga attctaatat aataatattc 3901141 actaaaagta agtgattacc ttttgttaaa aatataaaaa gctctcctgc ttttcaggag 3901201 agcttctatt ttggtatgcg aatcgttaat tgaatatatt cttcaaattc ttcttcttcc 3901261 gtattcaatt ttacaccgct gtcttccacc attgatagtg actggcgaat cgtgttcatc 3901321 gcaattcttg tatctctgct gaatgctttg cgtctcggct ttggctttct ctggccttgc 3901381 tccagcattt tcaccacgcg gtcttctgtc tgctttacat ttaaactttt ctcaataatc 3901441 tctgtgagca gtgtgacttg gagctcaggc tgtttcagcg gaatcagtgc tctggcatgg 3901501 cgctcggtga ttttcttctc cataatcgcc tcttggaccg gctgaggcag ctttaataac 3901561 cgaagcttat tcgcgattgt agactgccct tttcctaagc gctgtgcgag tgcctcctgt 3901621 gttaaatcat gcagctcaag cagcctagca taagcatgcg cttcctcaat agaagacagt 3901681 tcttcccgct gcaagttttc gattaacgcc acagaagcgg tttccgtgtc ggaaaaatcc 3901741 ttaataattg ccggaatctt ttcccactca agcgattgca ccgctctcca gcgtctttca 3901801 cctgcaatga gttcgtattg gccttcttct tctgtatgcc taacaacaat cggctgaata 3901861 atgccgtgtg tatgaatggt cattgctaac tctttgattt tttcatctga gaaaatggtg 3901921 cgtggctgaa aacggttggg aacgatagca tttaccggta tttccagaat ctcttctttg 3901981 tttgtatcat gttcagcaat ctccggctcc tgttccttct caccaagccc gaagaaacga 3902041 gagaatgaat gcttcatgta cctacaccac ctttaaaaac tgccattttt ataattctat 3902101 tttctcatgg tttttcctgc tgtacatcca tcaattttga tgaaaatatg atggtattgt 3902161 catatcaggc tgtctaaatt acccttcaat tggcgattta ttaggagttc ccggttttct 3902221 tggatacttc ttaggtgtat tttttatttt gcgtatcacc ataatattac gatcgctttc 3902281 ttcaataggc agcttaaaag aatggatatt ctcaagttct cctccaagcg tcgtgattgc 3902341 ttttttgcct gcattcagtt cttcttcagc tgatgcggct tttaaagcaa caaataaacc 3902401 gtttttcttc accagaggca agcaaagctc actcaaaaca gataatctcg caactgcgcg 3902461 cgccgtcaca atatcatagc tttcacgcac gtctttccgt tgcccgaacg tttcagctct 3902521 gtcatggcag aatgttgtat tctccaattg caaagcttca gacaactttt ctaaaaacgt 3902581 aatccgtttg tttagtgaat ccacgattgt gacatggagg tgcggaaagc atatttttat 3902641 cggcagactt ggaaaacccg ctcccgctcc aacatcacaa atcgtgttca cctgattgaa 3902701 gtcgacataa aaagcagctg taatggaatc ataaaaatgc tttaaataca cttctttttt 3902761 ctctgttatt gaagtcagat tgattttttc gttccattca accagcatgt cgtaatacag 3902821 ctcaaattgc tccagctgac ggggagaaag ggagatccct ttttccgcca aaccagaagt 3902881 gaattcttca atattcatgc cgtcatcctt tctactcggc tatcttcgca atgcgtccct 3902941 gctctaaata caccaataga attgaaatgt ccgccgggtt tacaccggaa atgcgggaag 3903001 cctgggcaac agacaaaggc cgtacatttt tcagtttttg acgcgcctcg gtcgcaatcc 3903061 ccttaattgc gtcataatca attcggtctg gaattttttt attttccatc ttcttcagtt 3903121 tttccacttg ctgaagagat ttttcaatat atccttcata tttcacttgg atttctactt 3903181 gttctgccac gtcttgagga accggcactt ctggcggcgc cagttttgtg actgtttcat 3903241 agttcatttc aggacgtttc atcaagtctg tgccgcgaac tccatctttc aattcgcttc 3903301 cgccaagaga acggatatat tcttgatttt ccggagacgg cttgataatt acagaatgaa 3903361 gacgtttttt ctccgcctcg atcgccgctt ttttcttctc aaaagccgca tagcgctcat 3903421 cagaaatcaa tccaatgcga tgtccgattt ctgtcagacg caaatcagca ttgtcatggc 3903481 gaagcagcaa tctgtattcc gcacgtgatg tcaaaagacg atatggctca ttggtacctt 3903541 ttgtcacaag gtcatcaatc agaacaccaa tataggcgtc agaacggctt agaattactt 3903601 cttcttttcc aagcgctttt cgtcctgcat tgattcccgc cataatccct tgtcccgcag 3903661 cttcttcata accggatgtt ccgttaattt ggcctgcagt ataaaggttt gtgatttttt 3903721 tggtttcaag tgtcggccat agctgtgtcg gtacgattgc atcatactcg atcgcatagc 3903781 cggctctcat catttgcacg ttttcaagtc caggaatcgt tgcaagcatt ctttgctgta 3903841 cgtcttctgg aagacttgta gataaacctt ggacatagac ttcctgtgta tttctgcctt 3903901 ccggctcaag gaagatttgg tgacgcggtt tatcattaaa acggacaact ttgtcttcaa 3903961 tggatgggca gtatcttggg cccgtacctt tgatcatacc ggaatacatc ggtgaacggt 3904021 gcaggttgct gtcaataatc tcatgtgtct cagggcttgt atatgtcagc cagcaaggga 3904081 gctgatctgt gatatattcc actgtttcat atgagaaagc gcgaggcaca tcgtcaccag 3904141 gctgaatttc cgttttgctg taatcaatcg tgtcgctttt aacgcgaggc ggcgtacctg 3904201 ttttaaaacg aacaaggtca aaaccgagtt cctccaaatg ctcagaaagc ttaatagaag 3904261 gctgctggtt attcgggccg cttgagtaag acagatcgcc aagaatgata cgtcctctta 3904321 aatatgtccc tgtcgtcatg acaactgctt tcgcacgata atgtgcgcct gtttgtgtaa 3904381 taacgcctcg gcattcgccg tcttcaacga tcagccgctc cacaattcct tgcagcaatg 3904441 ttaagtttgg ttctttttca agcgtatttt tcatttcgtg ctgatattgg aatttgtctg 3904501 cttgcgcacg caatgcacga accgcaggac cttttcctgt attcagcatt ctcatttgaa 3904561 tatgtgtttt atcgatgttt cttcccattt ctccgccgag cgcgtcaatt tcgcggacga 3904621 caatcccttt tgcggggccg ccgacagacg gattacatgg cataaatgca accatatcta 3904681 ggttgatggt caagacaagc gttttggcgc cttggcgtgc agatgcgagg gcagcctcaa 3904741 caccggcatg cccggcgcca atcacaatca catcgtattg gcctgcttca taccccatga 3904801 ttctagttcc tcctttaatt attttcctaa acagaattga gaaaagagct gatcaattaa 3904861 gctttcgtgg acagaatctc caatgatttc ccctaaaagc tcccagcatc ttgtaaggtc 3904921 aatttgcacc atgtcgatcg ggacatcctg ttcgatgccg ctaagcgcat cttcaatggc 3904981 gcgttttgct tgctgtaaaa tagtgatgtg acgtgtgttg ctgacataag tcagatcacc 3905041 gctttcaatg gcacccgtgt agaacagtga ttgaatcgct tcttccagat cattgatgcc 3905101 ttcctctttt aaaagagatg tcgtaacaac tggacgtcca ttggcaagct cacggacacg 3905161 ttcagtgtca atcttcggct caaggtcagt cttattcaaa atcacgataa catccatgcc 3905221 ctcaacggct tcaaaaagct tcacgtcttc ttcagaaagc tcttcactat aattaagcac 3905281 aagtaaaatc aggtccgctt cctttaggac ctggcgagaa cgttcaacac cgattcgctc 3905341 aacaatatcc tctgtttcac gaatacctgc tgtatcaacc agacgaagcg gaacgcccct 3905401 tacattcacg tattcctcaa tcacatcccg tgtcgttccg ggaatatcgg ttacaatggc 3905461 ttttgcctca tgaacgaggc tgttcagaag agatgatttt cctacgtttg gccggccgat 3905521 aatgacggta gaaagacctt cacgcaagat ttttccttgc tcagaagtcc tcagcagcgt 3905581 ctcaatttcc tttttcacgg cggttgcctt ttcgactaaa atctgatgcg tcatttcctc 3905641 tacatcatca tactccggat aatcaatatt cacctcaaca tgggccagtg tttctaaaat 3905701 ctcactgcgc aaacggcgca ccaaagcaga aagacgccct tccatttgat tcatagcaac 3905761 gttcattgcc cggtccgttt tcgctctgat taagtccata accgcttccg cctgtgaaag 3905821 atcgattcgg ccgtttaaaa acgcacgttt cgtaaattca ccaggctctg ccagtctcgc 3905881 tccctctctc aatgcaagct gaagcacttg gttcacagtc acaattcccc cgtgacagtt 3905941 aatctcgatg acatcttctc gtgtaaaagt tctcggcgct tttaacactg ataccattac 3906001 ttcctcaacg acacgatccg aaggtctgtc tacgatatga ccataatgaa tcgtatgtga 3906061 ttcgaccgag ctgagtgttt tccccttcgg tcccttataa attttatctg cgatttgaat 3906121 ggcttctggt ccgctcaacc gtacaatcgc aatcgcgcct tctcccatcg gtgtggaaat 3906181 tgccgcaatt gtatccatgt tgttcacctc tctttactta tacttcatct atataaaaaa 3906241 atttttatta tgccaaaact aaaagataac atagtttggt tcgaagtgga agatttgtta 3906301 tccacagaaa tagaaattcg tcccttatta ctttaactta tccacatgtg aataacaatt 3906361 aattttattt cctgaacttc ctttttatca acaggataca cctaaaaaga aaaaacttaa 3906421 acggcaaaac cttgatatta ctaggaaaag tagatttttc ggatacaaaa aaaccgaaat 3906481 ccaattttta tcggacttcg gttttatgct atcttttatg ggaaataacg agatgacgat 3906541 tttcgccttc acccattgaa tatgttttga tctggtggtt tgcatatcca gaaagagtat 3906601 cgtgaataat ttttctttcg ctggacggca tgggctcaag ctggatggat tttttcgttt 3906661 tcaaaacctg gtcagcaagc ttgatggcca gctggctcag tgtttctttt cttttcaaac 3906721 gatagttttc tgcatccacc gtcacatttt tatattggcc tggataacgg ttaagggcaa 3906781 gctgtgtcaa agtttcaagg gcgtttaaag tttgtcctct tttcccaatc aacaatgctg 3906841 ccttttcacc tgttatatga tatctcactg tctttttgct ttcttgaaca gtcacatcag 3906901 acttcccggc aatggcttcg gcaatcgttt gaagatataa cttcgcttgc tgaatcggat 3906961 caatcttttc aaccagcttt acgatcgcag gctttttacc gaaaataccg agaaaccctt 3907021 tgtttccctc ttcaataaca gtaatttcta ccttatcctt cgttaatccc aactcttgca 3907081 atccggactg tactgcttca tcgacatttc gccctgcagc agtcacattc ctcacttttt 3907141 ctttcctccg gctttttgcg gctcaggatt ttttttaata tcaggtcctt taatgaggaa 3907201 agtttgcgca atcataaaca agttaccaac tacccaataa agagaaagag ccgccgggaa 3907261 gttgatcgca aatacgataa tcataattgg cataatccaa agcatcatcg ccatttgcgg 3907321 attttgctgc gcattgccag ccatcatcag tttttgctga acaaatgtag cgacaccggc 3907381 aacgatagga agaatatagt aaggatcttt ttctcctaag tcaaaccata agaagctatg 3907441 ctctgaaatc gcctgggttc tcatgatcgc atgatagaat ccaattaaaa tcggcatctg 3907501 gatcaaaatc gggaaacatc ccgccaatgg attgacacca tgcttttgga ataaagccat 3907561 tgtttcctgt tgaagctttt gctgcgtttt ttgatccttt gagctgtatt tttctttaag 3907621 cttttgcatt tccggctgta aagcctgcat cgctttcgaa cttctcagct gcttaatcat 3907681 cagcggtaaa attaataaac gaattaaaat ggtaactaga ataattgaaa gcccgtagtt 3907741 atctcccgtc aatttcgcta catacgtaat gagctcagac aatggatata ctacgtactt 3907801 gtcccagaaa tgcggactat ctgcagtgat cggctctttc acactcgagc atccagccaa 3907861 aagcatgaat acgccaacca tacttaatag caaccctatt ctccttttca acaacatttc 3907921 ctcctataat taatctttac actcttttat tgcaaagcat acttgtatgt attttagcat 3907981 ctttcagttt taaatggtgt ctttttctga tcaaccagaa aggaagcgct tttaaaagtt 3908041 gtaagaaagc agtggtgatg cctactttga cgaagatttc ttatataatg aagactttct 3908101 gaatagatgc tgcagacttt ttttcgtttc ctcatatgtc agctggctcg ccggttttct 3908161 ggcaataatg atgtaatcct tttccttcag tctctctttc tcttcaagaa aggcctgccg 3908221 aatcaaacgt ttgatccgat ttcgcatcac agcattgcca atttttttgc tgacggaaag 3908281 cccgacacgc agttcatcat tttcaggctg atcaagcgta tataagacaa actggcggtt 3908341 tgcaactgat gtcccatgtt taaacacttt ttgaaaatct tcatttttct ttaaacgatt 3908401 tcgcttcttc aaatgactca ctccgatact ggctggcaga aacttttaaa atttattatg 3908461 aacatgagat gcatctgaac caggaagcat gccccggttc attacgcatc acatctatct 3908521 tttcccataa cgtgaaaaaa gaccactgac attattcagt ggcctaagct gataatactt 3908581 ttctgccttt gcggcgacgg cgtgctaaaa ctagacgacc gttttttgaa ctcatacggc 3908641 ttctgaagcc atgaactttg ctgcgtttac ggttattcgg ttggaatgtt cttttcattt 3908701 atgacacctc cctcgaggaa tagctgttaa agacagtctt acttattata tttgcgttac 3908761 ctattcattg tcaacttcac tagtgctttt atttcttgca accataatag gataccatac 3908821 cttttcaact ttcgaaacct tattttttag attccttaat tttacggaaa aaagacaaat 3908881 tcaaacaatt tgcccctaaa atcacgcatg tggat //